Assessment of advanced technologies for transit and rideshare applications : final report

DOT National Transportation Integrated Search

This report presents the results of a study to examine advanced technologies and systems that can be applied to high occupancy vehicles, ridesharing and transit needs. Advanced technologies can be used to encourage the use of transit and rideshare fa...

Laser program. Annual report, 1978

DOE Office of Scientific and Technical Information (OSTI.GOV)

Monsler, M.J.; Jarman, B.D.

1979-03-01

This volume documents progress in advanced quantum electronics - primarily the quest for advanced rep-rateable short-wavelength lasers with high efficiency. Application studies in electrical energy production and fissile fuel production are also described. Selected highlights of the advanced isotope separation program are also presented. (MOW)

Differences in Attitudes and Values of Students in Relation to Program of Study at a College of Advanced Education

ERIC Educational Resources Information Center

Feather, N. T.; Collins, J. Maxwell

1974-01-01

This paper presents and discusses the results of an empirical study of value orientations of a sample of students entering three different programs of study at a college of advanced education. (Editor)

Advanced Platform Systems Technology study. Volume 3: Supporting data

NASA Technical Reports Server (NTRS)

1983-01-01

The overall study effort proceeded from the identification of 106 technology topics to the selection of 5 for detail trade studies. The technical issues and options were evaluated through the trade process. Finally, individual consideration was given to costs and benefits for the technologies identified for advancement. Eight priority technology items were identified for advancement. Supporting data generated during the trade selection and trade study process were presented. Space platform requirements, trade study and cost benefits analysis, and technology advancement planning are advanced. The structured approach used took advantage of a number of forms developed to ensure that a consistent approach was employed by each of the diverse specialists that participated. These forms were an intrinsic part of the study protocol.

Beyond the Baseline: Proceedings of the Space Station Evolution Symposium. Volume 1, Part 2; Space Station Freedom

NASA Technical Reports Server (NTRS)

1990-01-01

This report contains the individual presentations delivered at the Space Station Evolution Symposium in League City, Texas on February 6, 7, 8, 1990. Personnel responsible for Advanced Systems Studies and Advanced Development within the Space Station Freedom Program reported on the results of their work to date. Systems Studies presentations focused on identifying the baseline design provisions (hooks and scars) necessary to enable evolution of the facility to support changing space policy and anticipated user needs. Also emphasized were evolution configuration and operations concepts including on-orbit processing of space transfer vehicles. Advanced Development task managers discussed transitioning advanced technologies to the baseline program, including those near-term technologies which will enhance the safety and productivity of the crew and the reliability of station systems. Special emphasis was placed on applying advanced automation technology to ground and flight systems.

Beyond the Baseline: Proceedings of the Space Station Evolution Symposium. Volume 2, Part 2; Space Station Freedom Advanced Development Program

NASA Technical Reports Server (NTRS)

1990-01-01

This report contains the individual presentations delivered at the Space Station Evolution Symposium in League City, Texas on February 6, 7, 8, 1990. Personnel responsible for Advanced Systems Studies and Advanced Development within the Space Station Freedom program reported on the results of their work to date. Systems Studies presentations focused on identifying the baseline design provisions (hooks and scars) necessary to enable evolution of the facility to support changing space policy and anticipated user needs. Also emphasized were evolution configuration and operations concepts including on-orbit processing of space transfer vehicles. Advanced Development task managers discussed transitioning advanced technologies to the baseline program, including those near-term technologies which will enhance the safety and productivity of the crew and the reliability of station systems. Special emphasis was placed on applying advanced automation technology to ground and flight systems. This publication consists of two volumes. Volume 1 contains the results of the advanced system studies with the emphasis on reference evolution configurations, system design requirements and accommodations, and long-range technology projections. Volume 2 reports on advanced development tasks within the Transition Definition Program. Products of these tasks include: engineering fidelity demonstrations and evaluations on Station development testbeds and Shuttle-based flight experiments; detailed requirements and performance specifications which address advanced technology implementation issues; and mature applications and the tools required for the development, implementation, and support of advanced technology within the Space Station Freedom Program.

The Development of Nanotechnologies and Advanced Materials Industry in Science and Entrepreneurship: Socioeconomic and Technical Indicators. A Case Study of Latvia (Part One)

NASA Astrophysics Data System (ADS)

Geipele, I.; Geipele, S.; Staube, T.; Ciemleja, G.; Zeltins, N.

2016-08-01

The present scientific paper is the first part of two publications, where the authors obtain results from the scientific research presented in a series of works on the development of the nanotechnologies and advanced materials industry in science and entrepreneurship in Latvia. The study has a focus on finding proper socioeconomic and technical indicators. It provides resume on a scope of the study. The paper contains the developed structure of engineering economic indicator system, determined groups of indicators for assessment of the development of nanotechnologies and advanced materials industry in Latvia and results of the evaluation of the obtained statistics on the economic indicators.

Concept for a Satellite-Based Advanced Air Traffic Management System : Volume 10. Subsystem Performance Requirements.

DOT National Transportation Integrated Search

1974-02-01

The volume presents the results of the subsystem performance requirements study for an Advanced Air Traffic Management System (AATMS). The study determined surveillance and navigation subsystem requirements for terminal and enroute area operations. I...

Wind driven erosion and the effects of particulate electrification

NASA Astrophysics Data System (ADS)

Merrison, J. P.; Bak, E.; Finster, K.; Gunnlaugsson, H. P.; Holstein-Rathlou, C.; Knak Jensen, S.; Nørnberg, P.; Rasmussen, K. R.

2012-09-01

Several related aspects of Aeolian activity are presently being studied in the laboratory, the most recent advances in this field will be presented. These include simulating wind driven erosion in the laboratory, quantifying erosion rates and the study of mineral change due to mechanical activation. Also advances in our understanding of the electrification of sand/dust particles is being made and how this phenomenon affects their behavior.

Use of Double-Loop Learning to Combat Advanced Persistent Threat: Multiple Case Studies

ERIC Educational Resources Information Center

Lamb, Christopher J.

2013-01-01

The Advanced Persistent Threat (APT) presents an ever present and more growing threat to organizations across the globe. Traditional Information Technology (IT) incident response falls short in effectively addressing this threat. This researcher investigated the use of single-loop and double-loop learning in two organizations with internal…

Application of advanced technologies to future military transports

NASA Technical Reports Server (NTRS)

Clark, Rodney L.; Lange, Roy H.; Wagner, Richard D.

1990-01-01

Long range military transport technologies are addressed with emphasis of defining the potential benefits of the hybrid laminar flow control (HLFC) concept currently being flight tested. Results of a 1990's global range transport study are presented showing the expected payoff from application of advanced technologies. Technology forecast for military transports is also presented.

Prevalence of advanced adenomas in small and diminutive colon polyps using direct measurement of size.

PubMed

Tsai, Franklin C; Strum, Williamson B

2011-08-01

Most studies reporting polyp size use visual estimates. Determining the prevalence of advanced histology based on direct measurement of polyp size may help guide the management of polyps found at optical colonoscopy (OC) and CT colonography (CTC). We designed a large, prospective study to assess the prevalence of advanced adenomas based on direct measurement of polyp size by a certified pathologists' assistant as reported in the pathology report. Patients between 40 and 89 years of age who presented for screening colonoscopy were included in our study. Advanced adenomas were defined as ≥10 mm or ≥25% villous features, high grade dysplasia or cancer. Polyps were divided by size into three groups: diminutive (≤5 mm), small (6-9 mm) and large (≥10 mm). If more than one adenoma was present, the most advanced was used for analysis. We evaluated 6,905 consecutive patients referred for colonoscopy between January 2005 and December 2006. Of the 4,967 who met the inclusion criteria, the mean age was 58.8 and consisted of 59% women. Overall, 930 (18.7%) had an adenoma; 248 (5%) were advanced adenomas including 8 (0.16%) cancers. Of 89 polyps≥10 mm, 76 (85%) had advanced histology; of 247 polyps 6-9 mm, 67 (27%) were advanced; of 1,025 polyps ≤5 mm, 105 (10%) were advanced. Thus, 172 of 248 (69%) patients with advanced adenomas had small or diminutive adenomas. Our data indicate the majority (69%) of advanced adenomas are <10 mm. Even among polyps≤5 mm, there was an appreciable prevalence of advanced adenomas (10%). These findings may help guide the management of sub-centimeter colon polyps found by OC or CTC.

Role of HPC in Advancing Computational Aeroelasticity

NASA Technical Reports Server (NTRS)

Guruswamy, Guru P.

2004-01-01

On behalf of the High Performance Computing and Modernization Program (HPCMP) and NASA Advanced Supercomputing Division (NAS) a study is conducted to assess the role of supercomputers on computational aeroelasticity of aerospace vehicles. The study is mostly based on the responses to a web based questionnaire that was designed to capture the nuances of high performance computational aeroelasticity, particularly on parallel computers. A procedure is presented to assign a fidelity-complexity index to each application. Case studies based on major applications using HPCMP resources are presented.

Discharge of Non-Acute Coronary Syndrome Chest Pain Patients From Emergency Care to an Advanced Nurse Practitioner-Led Chest Pain Clinic: A Cross-Sectional Study of Referral Source and Final Diagnosis.

PubMed

Ingram, Shirley J; McKee, Gabrielle; Quirke, Mary B; Kelly, Niamh; Moloney, Ashling

Chest pain is a common presentation to emergency departments (EDs). Pathways for patients with non-acute coronary syndrome (ACS) chest pain are not optimal. An advanced cardiology nurse-led chest pain service was commenced to address this. The aim of the study was to assess the outcomes of non-ACS patients discharged from ED to an advanced cardiology nurse-led chest pain clinic and compare by referral type (nurse or ED physician). The service consisted of advanced cardiology nurse or ED physician consultation in the ED and discharge to advanced nurse-led chest pain clinic review less than 72 hours after discharge. Referrals were by the advanced nurses during consult hours and out-of-hours were by the ED physicians. Data were extracted from case notes. This was a 1-site cross-sectional study of patients attending the chest pain clinic over 2 years. Confirmed coronary disease was diagnosed in 24% of patients. Of the 1041 patients, 45% were referred by the advanced nurses, who referred significantly more patients who were older (56.5 years/52.3 years), had positive exercise stress test results (21%/12%), and were diagnosed with stable coronary artery disease (19%/11%) and less patients with musculoskeletal diagnosis (5%/13%) and other noncardiac pain (36%/45%). The study fills a gap in the literature on the follow up of non-ACS patients who present to ED and used advanced cardiology nursing expertise in the ED and chest pain clinic. The advanced nurse referred more patients who were diagnosed with coronary disease, reflecting the expertise, experience, and efficiency of the advanced cardiology nurse-led service.

A Case Study on Teaching the Topic "Experimental Unit" and How It Is Presented in Advanced Placement Statistics Textbooks

ERIC Educational Resources Information Center

Perrett, Jamis J.

2012-01-01

This article demonstrates how textbooks differ in their description of the term "experimental unit". Advanced Placement Statistics teachers and students are often limited in their statistical knowledge by the information presented in their classroom textbook. Definitions and descriptions differ among textbooks as well as among different…

Advanced Heritage Learners of Spanish: A Sociolinguistic Profile for Pedagogical Purposes

ERIC Educational Resources Information Center

Alarcon, Irma

2010-01-01

This article reports on an extensive survey administered to advanced heritage language (HL) learners to examine their language behaviors, attitudes, and backgrounds. To date, there have been no detailed categorizations of advanced HL learners to guide classroom instruction and curriculum design. Thus the present study is a first attempt to fill…

Advanced missions safety. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

1972-01-01

Three separate studies were performed under the general category of advanced missions safety. Each dealt with a separate issue, was a self-contained effort, and was independent of the other two studies. The studies are titled: (1) space shuttle rescue capability, (2) experiment safety, and (3) emergency crew transfer. A separate discussion of each study is presented.

Integration of Technology, Curriculum, and Professional Development for Advancing Middle School Mathematics: Three Large-Scale Studies

ERIC Educational Resources Information Center

Roschelle, Jeremy; Shechtman, Nicole; Tatar, Deborah; Hegedus, Stephen; Hopkins, Bill; Empson, Susan; Knudsen, Jennifer; Gallagher, Lawrence P.

2010-01-01

The authors present three studies (two randomized controlled experiments and one embedded quasi-experiment) designed to evaluate the impact of replacement units targeting student learning of advanced middle school mathematics. The studies evaluated the SimCalc approach, which integrates an interactive representational technology, paper curriculum,…

Finding a Balance: Fifteen Institutional Case Studies on the Relationship between Part-Time Work and Advanced Level Study. Report.

ERIC Educational Resources Information Center

Hodgson, Ann, Ed.; Spours, Ken, Ed.

This document presents and discusses case studies that examined the relationship between part-time employment and advanced level study at 15 schools in Essex, England. "Foreword" (David Jones) provides a brief overview of the project. "Finding a Balance--Fifteen Institutional Case Studies on the Relationship between Part-time Work…

Advances in biotechnology and linking outputs to variation in complex traits: Plant and Animal Genome meeting January 2012.

PubMed

Appels, R; Barrero, R; Bellgard, M

2012-03-01

The Plant and Animal Genome (PAG, held annually) meeting in January 2012 provided insights into the advances in plant, animal, and microbe genome studies particularly as they impact on our understanding of complex biological systems. The diverse areas of biology covered included the advances in technologies, variation in complex traits, genome change in evolution, and targeting phenotypic changes, across the broad spectrum of life forms. This overview aims to summarize the major advances in research areas presented in the plenary lectures and does not attempt to summarize the diverse research activities covered throughout the PAG in workshops, posters, presentations, and displays by suppliers of cutting-edge technologies.

Motion control of multi-actuator hydraulic systems for mobile machineries: Recent advancements and future trends

NASA Astrophysics Data System (ADS)

Xu, Bing; Cheng, Min

2018-06-01

This paper presents a survey of recent advancements and upcoming trends in motion control technologies employed in designing multi-actuator hydraulic systems for mobile machineries. Hydraulic systems have been extensively used in mobile machineries due to their superior power density and robustness. However, motion control technologies of multi-actuator hydraulic systems have faced increasing challenges due to stringent emission regulations. In this study, an overview of the evolution of existing throttling control technologies is presented, including open-center and load sensing controls. Recent advancements in energy-saving hydraulic technologies, such as individual metering, displacement, and hybrid controls, are briefly summarized. The impact of energy-saving hydraulic technologies on dynamic performance and control solutions are also discussed. Then, the advanced operation methods of multi-actuator mobile machineries are reviewed, including coordinated and haptic controls. Finally, challenges and opportunities of advanced motion control technologies are presented by providing an overall consideration of energy efficiency, controllability, cost, reliability, and other aspects.

Formulation of advanced consumables management models: Executive summary. [modeling spacecraft environmental control, life support, and electric power supply systems

NASA Technical Reports Server (NTRS)

Daly, J. K.; Torian, J. G.

1979-01-01

An overview of studies conducted to establish the requirements for advanced subsystem analytical tools is presented. Modifications are defined for updating current computer programs used to analyze environmental control, life support, and electric power supply systems so that consumables for future advanced spacecraft may be managed.

Inter- and Intralingual Lexical Influences in Advanced Learners' French L3 Oral Production

ERIC Educational Resources Information Center

Lindqvist, Christina

2010-01-01

The present study investigates lexical inter- and intralingual influences in the oral production of 14 very advanced learners of French L3. Lexical deviances are divided into two main categories: formal influence and meaning-based influence. The results show that, as predicted with respect to advanced learners, meaning-based influence is the most…

Advanced general aviation engine/airframe integration study

NASA Technical Reports Server (NTRS)

Zmroczek, L. A.

1982-01-01

A comparison of the in-airframe performance and efficiency of the advanced engine concepts is presented. The results indicate that the proposed advanced engines can significantly improve the performance and economy of general aviation airplanes. The engine found to be most promising is the highly advanced version of a rotary combustion (Wankel) engine. The low weight and fuel consumption of this engine, as well as its small size, make it suited for aircraft use.

Advance care planning for older people in Australia presenting to the emergency department from the community or residential aged care facilities.

PubMed

Street, Maryann; Ottmann, Goetz; Johnstone, Megan-Jane; Considine, Julie; Livingston, Patricia M

2015-09-01

The purpose of this retrospective, cross-sectional study was to determine the prevalence of advance care planning (ACP) among older people presenting to an Emergency Department (ED) from the community or a residential aged care facility. The study sample comprised 300 older people (aged 65+ years) presenting to three Victorian EDs in 2011. A total of 150 patients transferred from residential aged care to ED were randomly selected and then matched to 150 people who lived in the community and attended the ED by age, gender, reason for ED attendance and triage category on arrival. Overall prevalence of ACP was 13.3% (n = 40/300); over one-quarter (26.6%, n = 40/150) of those presenting to the ED from residential aged care had a documented Advance Care Plan, compared to none (0%, n = 0/150) of the people from the community. There were no significant differences in the median ED length of stay, number of investigations and interventions undertaken in ED, time seen by a doctor or rate of hospital admission for those with an Advance Care Plan compared to those without. Those with a comorbidity of cerebrovascular disease or dementia and those assessed with impaired brain function were more likely to have a documented Advance Care Plan on arrival at ED. Length of hospital stay was shorter for those with an Advance Care Plan [median (IQR) = 3 days (2-6) vs. 6 days (2-10), P = 0.027] and readmission lower (0% vs. 13.7%). In conclusion, older people from the community transferred to ED were unlikely to have a documented Advance Care Plan. Those from residential aged care who were cognitively impaired more frequently had an Advance Care Plan. In the ED, decisions of care did not appear to be influenced by the presence or absence of Advance Care Plans, but length of hospital admission was shorter for those with an Advance Care Plan. © 2014 John Wiley & Sons Ltd.

Space Station Freedom automation and robotics: An assessment of the potential for increased productivity

NASA Technical Reports Server (NTRS)

Weeks, David J.; Zimmerman, Wayne F.; Swietek, Gregory E.; Reid, David H.; Hoffman, Ronald B.; Stammerjohn, Lambert W., Jr.; Stoney, William; Ghovanlou, Ali H.

1990-01-01

This report presents the results of a study performed in support of the Space Station Freedom Advanced Development Program, under the sponsorship of the Space Station Engineering (Code MT), Office of Space Flight. The study consisted of the collection, compilation, and analysis of lessons learned, crew time requirements, and other factors influencing the application of advanced automation and robotics, with emphasis on potential improvements in productivity. The lessons learned data collected were based primarily on Skylab, Spacelab, and other Space Shuttle experiences, consisting principally of interviews with current and former crew members and other NASA personnel with relevant experience. The objectives of this report are to present a summary of this data and its analysis, and to present conclusions regarding promising areas for the application of advanced automation and robotics technology to the Space Station Freedom and the potential benefits in terms of increased productivity. In this study, primary emphasis was placed on advanced automation technology because of its fairly extensive utilization within private industry including the aerospace sector. In contrast, other than the Remote Manipulator System (RMS), there has been relatively limited experience with advanced robotics technology applicable to the Space Station. This report should be used as a guide and is not intended to be used as a substitute for official Astronaut Office crew positions on specific issues.

Factors influencing the quality of life of patients with advanced cancer.

PubMed

Park, Sun-A; Chung, Seung Hyun; Lee, Youngjin

2017-02-01

The present study aimed to determine the predictors of quality of life (QOL) of patients with advanced cancer. A cross-sectional study involving 494 patients with advanced cancer was conducted using the Memorial Symptom Assessment Scale-Short Form, the Karnofsky Performance Status Scale, the World Health Organization Disability Assessment Schedule (Korean version), and the European Organization for Research and Treatment of Cancer Quality of Life Core 30. Regression analyses showed that physical and psychological symptoms significantly predicted the patients' QOL and explained 28.8% of the variance in QOL. Moreover, lack of energy was the patients' most prevalent symptom. The results of the present study will serve as fundamental data upon which the development of an intervention will be based so as to enhance the patients' QOL. Accordingly, an effective management of symptoms and performance maintenance should be considered in the future as key factors in providing support and establishing palliative care systems for patients with advanced cancer. Copyright © 2016. Published by Elsevier Inc.

In Pursuit of Decisive Action: Air Power’s Impact On the Guadalcanal Campaign

DTIC Science & Technology

2013-06-01

PRESENTED TO THE FACULTY OF THE SCHOOL OF ADVANCED AIR AND SPACE STUDIES FOR COMPLETION OF GRADUATION REQUIREMENTS SCHOOL OF ADVANCED AIR AND...while the other seeks to reestablish parity in the essential condition. To summarize, air power is not universally decisive because at present there...potential in terms of decisiveness. Although the concept of decisiveness was not new to warfare, its present emphasis stems from the writings of two

Career, Family, and Institutional Variables in the Work Lives of Academic Women in the Chemical Sciences

NASA Astrophysics Data System (ADS)

Fassinger, Ruth E.; Scantlebury, Kathryn; Richmond, Geraldine

This article presents quantitative results of a study of 139 academic women in the chemical sciences who participated in a professional development program sponsored by the Committee on the Advancement of Women Chemists. The study investigated variables frequently examined in the vocational psychology of women: approaches to achievement, coping strategies, career advancement, the home-work interface, workplace climate, and mentoring. The article presents and discusses results in the context of unique issues faced by women in scientific careers.

Overview of ECRH experimental results

NASA Astrophysics Data System (ADS)

Lloyd, Brian

1998-08-01

A review of the present status of electron cyclotron heating and current drive experiments in toroidal fusion devices is presented. In addition to basic heating and current drive studies the review also addresses advances in wave physics and the application of electron cyclotron waves for instability control, transport studies, pre-ionization/start-up assist, etc. A comprehensive overview is given with particular emphasis on recent advances since the major review of Erckmann and Gasparino (1994) ( 36 1869), including results from the latest generation of high-power, high-frequency experiments.

Advancing automation and robotics technology for the space station and the US economy

NASA Technical Reports Server (NTRS)

Cohen, A.

1985-01-01

In response to Public Law 98-371, dated July 18, 1984, the NASA Advanced Technology Advisory Committee has studied automation and rebotics for use in the space station. The Executive Overview, Volume 1 presents the major findings of the study and recommends to NASA principles for advancing automation and robotics technologies for the benefit of the space station and of the U.S. economy in general. As a result of its study, the Advanced Technology Advisory Committee believes that a key element of technology for the space station is extensive use of advanced general-purpose automation and robotics. These systems could provide the United States with important new methods of generating and exploiting space knowledge in commercial enterprises and thereby help preserve U.S. leadership in space.

An airline study of advanced technology requirements for advanced high speed commercial transport engines. 1: Engine design study assessment

NASA Technical Reports Server (NTRS)

Sallee, G. P.

1973-01-01

The advanced technology requirements for an advanced high speed commercial tranport engine are presented. The results of the phase 1 study effort cover the following areas: (1) statement of an airline's major objectives for future transport engines, (2) airline's method of evaluating engine proposals, (3) description of an optimum engine for a long range subsonic commercial transport including installation and critical design features, (4) discussion of engine performance problems and experience with performance degradation, (5) trends in engine and pod prices with increasing technology and objectives for the future, (6) discussion of the research objectives for composites, reversers, advanced components, engine control systems, and devices to reduce the impact of engine stall, and (7) discussion of the airline objectives for noise and pollution reduction.

Evaluation of bike boxes at signalized intersections.

DOT National Transportation Integrated Search

2011-01-01

This report presents a before-after study of bike boxes at 10 signalized intersections in Portland, Oregon. The bike boxes, also known as advanced stop lines or advanced stop boxes, were installed to increase visibility of cyclists and reduce conflic...

Stereospecificity of NAD+/NADH Reactions: A Project Experiment for Advanced Undergraduates.

ERIC Educational Resources Information Center

Lowrey, Jonathan S.; And Others

1981-01-01

Presents background information, materials needed, and experimental procedures to study enzymes dependent on pyridine nucleotide coenzymes (NAD/NADH). The experiments, suitable for advanced organic or biochemistry courses, require approximately 10-15 hours to complete. (SK)

Investigation of an advanced fault tolerant integrated avionics system

NASA Technical Reports Server (NTRS)

Dunn, W. R.; Cottrell, D.; Flanders, J.; Javornik, A.; Rusovick, M.

1986-01-01

Presented is an advanced, fault-tolerant multiprocessor avionics architecture as could be employed in an advanced rotorcraft such as LHX. The processor structure is designed to interface with existing digital avionics systems and concepts including the Army Digital Avionics System (ADAS) cockpit/display system, navaid and communications suites, integrated sensing suite, and the Advanced Digital Optical Control System (ADOCS). The report defines mission, maintenance and safety-of-flight reliability goals as might be expected for an operational LHX aircraft. Based on use of a modular, compact (16-bit) microprocessor card family, results of a preliminary study examining simplex, dual and standby-sparing architectures is presented. Given the stated constraints, it is shown that the dual architecture is best suited to meet reliability goals with minimum hardware and software overhead. The report presents hardware and software design considerations for realizing the architecture including redundancy management requirements and techniques as well as verification and validation needs and methods.

Advanced Study Center: Proceedings of the National Faculty Plenary Conference (Columbus, Ohio, October 30-November 1, 1978).

ERIC Educational Resources Information Center

Jackson, Elise B., Ed.; Russell, Earl B., Ed.

These proceedings contain presentations made at the National Faculty Plenary Conference, whose theme, Nurturing Vocational Education's Leadership and Intellectual Capital, involved these topics: planning, evaluation, recruitment, and policy implications as they relate to the development and implementation of an Advanced Study Center. Introductory…

Advancing Career Counseling and Employment Support for Survivors: An Intervention Evaluation

ERIC Educational Resources Information Center

Davidson, M. Meghan; Nitzel, Camie; Duke, Alysondra; Baker, Cynthia M.; Bovaird, James A.

2012-01-01

The purpose of this research was to conduct a replication-based and extension study examining the effectiveness of a 5-week career group counseling intervention, Advancing Career Counseling and Employment Support for Survivors (ACCESS; Chronister, 2008). The present study was conducted in a markedly different geographic region within a larger…

Evaluation of the Effectiveness of an Advance Organizer in a Medical Microbiology Course.

ERIC Educational Resources Information Center

Slock, James A.; And Others

1980-01-01

An advance organizer is a set of conceptual statements about the unifying ideas of a topic in terms already familiar to the learner. A study is reported that sought to determine whether two presentations of an advance organizer for a unit on pathogenic bacteria would result in increasing medical students' knowledge and ability to solve problems in…

Recent Advances in Archaeological Chemistry: A Summary of the Three Major Papers Presented as an Introduction to the Archeological Chemistry Symposium, Anaheim, California

NASA Astrophysics Data System (ADS)

Chen, Wen; Orna, Mary Virginia; O. S., U.

1996-06-01

Modern archaeology is fully supported by advances in science and technology. With the development of chemical and biochemical analyses, the task of the archaeological chemist has become more complex than ever over the past decade. In the symposium on archaeological chemistry held at the American Chemical Society National Meeting in Anaheim, California, from April 2-6, 1995, three noted scientists who have made seminal contributions in their respective fields presented an accompanying pedagogical symposium to provide introductory information on how modern chemistry and biochemistry have revolutionized modern archaeological studies at a molecular level. These three scientists and their presentations were: Stanley Ambrose, "Advances in Stable Isotope Analysis in Dietary Reconstruction"; Svante Pääbo, "Ancient DNA as a Means to Study the History of Humans and Extinct Creatures"; and Robert Hedges, "Radiocarbon Dating of Archaeological Bone by Accelerator Mass Spectrometry.

Analyzing Idioms and Their Frequency in Three Advanced ILI Textbooks: A Corpus-Based Study

ERIC Educational Resources Information Center

Alavi, Sepideh; Rajabpoor, Aboozar

2015-01-01

The present study aimed at identifying and quantifying the idioms used in three ILI "Advanced" level textbooks based on three different English corpora; MICASE, BNC and the Brown Corpus, and comparing the frequencies of the idioms across the three corpora. The first step of the study involved searching the books to find multi-word…

Evidence-Based Advances in Avian Medicine.

PubMed

Summa, Noémie M; Guzman, David Sanchez-Migallon

2017-09-01

This article presents relevant advances in avian medicine and surgery over the past 5 years. New information has been published to improve clinical diagnosis in avian diseases. This article also describes new pharmacokinetic studies. Advances in the understanding and treatment of common avian disorders are presented in this article, as well. Although important progress has been made over the past years, there is still much research that needs to be done regarding the etiology, pathophysiology, diagnosis, and treatment of avian diseases and evidence-based information is still sparse in the literature. Copyright © 2017 Elsevier Inc. All rights reserved.

Ultrafast Phenomena XIV

NASA Astrophysics Data System (ADS)

Kobayashi, Takayoshi; Okada, Tadashi; Kobayashi, Tetsuro; Nelson, Keith A.; de Silvestri, Sandro

Ultrafast Phenomena XIV presents the latest advances in ultrafast science, including ultrafast laser and measurement technology as well as studies of ultrafast phenomena. Pico-, femto-, and atosecond processes relevant in physics, chemistry, biology, and engineering are presented. Ultrafast technology is now having a profound impact within a wide range of applications, among them imaging, material diagnostics, and transformation and high-speed optoelectronics . This book summarizes results presented at the 14th Ultrafast Phenomena Conference and reviews the state of the art in this important and rapidly advancing field.

Small transport aircraft technology. [STAT

NASA Technical Reports Server (NTRS)

Galloway, T. L.

1981-01-01

The results of contracted studies identifying the potential benefits of advanced technology are presented. Current in house studies and research efforts are discussed. An overview of the proposed technology elements in STAT research is presented.

Space Electrochemical Research and Technology Conference, 2nd, Cleveland, OH, Apr. 11-13, 1989, Proceedings

NASA Technical Reports Server (NTRS)

O'Donnell, Patricia M. (Editor)

1990-01-01

Attention is given to topics of advanced concepts, hydrogen-oxygen fuel cells and electrolyzers, nickel electrodes, and advanced rechargeable batteries. Papers are presented on human exploration mission studies, advanced rechargeable sodium batteries with novel cathodes, advanced double-layer capacitors, recent advances in solid-polymer electrolyte fuel cell technology with low platinum loading electrodes, electrocatalysts for oxygen electrodes in fuel cells and water electrolyzers for space applications, and the corrosion testing of candidates for the alkaline fuel cell cathode. Other papers are on a structural comparison of nickel electodes and precursor phases, the application of electrochemical impedance spectroscopy for characterizing the degradation of Ni(OH)2/NiOOH electrodes, advances in lightweight nickel electrode technology, multimission nickel-hydrogen battery cell for the 1990s, a sodium-sulfur battery flight experiment definition study, and advances in ambient-temperature secondary lithium cells.

Field Evaluation of Advanced Methods of Subsurface Exploration for Transit Tunneling

DOT National Transportation Integrated Search

1980-06-01

This report presents the results of a field evaluation of advanced methods of subsurface exploration on an ongoing urban rapid transit tunneling project. The objective of this study is to evaluate, through a field demonstration project, the feasibili...

Space Station Human Factors Research Review. Volume 1: EVA Research and Development

NASA Technical Reports Server (NTRS)

Cohen, Marc M. (Editor); Vykukal, H. C. (Editor)

1988-01-01

An overview is presented of extravehicular activity (EVA) research and development activities at Ames. The majority of the program was devoted to presentations by the three contractors working in parallel on the EVA System Phase A Study, focusing on Implications for Man-Systems Design. Overhead visuals are included for a mission results summary, space station EVA requirements and interface accommodations summary, human productivity study cross-task coordination, and advanced EVAS Phase A study implications for man-systems design. Articles are also included on subsea approach to work systems development and advanced EVA system design requirements.

Research Opportunities in Advanced Aerospace Concepts

NASA Technical Reports Server (NTRS)

Jones, Gregory S.; Bangert, Linda S.; Garber, Donald P.; Huebner, Lawrence D.; McKinley, Robert E.; Sutton, Kenneth; Swanson, Roy C., Jr.; Weinstein, Leonard

2000-01-01

This report is a review of a team effort that focuses on advanced aerospace concepts of the 21st Century. The paper emphasis advanced technologies, rather than cataloging every unusual aircraft that has ever been attempted. To dispel the myth that "aerodynamics is a mature science" an extensive list of "What we cannot do, or do not know" was enumerated. A zeit geist, a feeling for the spirit of the times, was developed, based on existing research goals. Technological drivers and the constraints that might influence these technological developments in a future society were also examined. The present status of aeronautics, space exploration, and non-aerospace applications, both military and commercial, including enabling technologies are discussed. A discussion of non-technological issues affecting advanced concepts research is presented. The benefit of using the study of advanced vehicles as a tool to uncover new directions for technology development is often necessary. An appendix is provided containing examples of advanced vehicle configurations currently of interest.

Advancing automation and robotics technology for the Space Station and for the US economy. Volume 1: Executive overview

NASA Technical Reports Server (NTRS)

1985-01-01

In response to Public Law 98-371, dated July 18, 1984, the NASA Advanced Technology Advisory Committee has studied automation and robotics for use in the Space Station. The Executive Overview, Volume 1 presents the major findings of the study and recommends to NASA principles for advancing automation and robotics technologies for the benefit of the Space Station and of the U.S. economy in general. As a result of its study, the Advanced Technology Advisory Committee believes that a key element of technology for the Space Station is extensive use of advanced general-purpose automation and robotics. These systems could provide the United States with important new methods of generating and exploiting space knowledge in commercial enterprises and thereby help preserve U.S. leadership in space.

Performance of Children and Adolescents with Asperger Syndrome or High-Functioning Autism on Advanced Theory of Mind Tasks

ERIC Educational Resources Information Center

Kaland, Nils; Callesen, Kirsten; Moller-Nielsen, Annette; Mortensen, Erik Lykke; Smith, Lars

2008-01-01

Although a number of advanced theory of mind tasks have been developed, there is a dearth of information on whether performances on different tasks are associated. The present study examined the performance of 21 children and adolescents with diagnoses of Asperger syndrome (AS) and 20 typically developing controls on three advanced theory of mind…

Preliminary design study of advanced composite blade and hub and nonmechanical control system for the tilt-rotor aircraft. Volume 2: Project planning data

NASA Technical Reports Server (NTRS)

1980-01-01

Project planning data for a rotor and control system procurement and testing program for modifications to the XV-15 tilt-rotor research demonstrator aircraft is presented. The design, fabrication, and installation of advanced composite blades compatible with the existing hub, an advanced composite hub, and a nonmechanical control system are required.

Performance and Weight Estimates for an Advanced Open Rotor Engine

NASA Technical Reports Server (NTRS)

Hendricks, Eric S.; Tong, Michael T.

2012-01-01

NASA s Environmentally Responsible Aviation Project and Subsonic Fixed Wing Project are focused on developing concepts and technologies which may enable dramatic reductions to the environmental impact of future generation subsonic aircraft. The open rotor concept (also historically referred to an unducted fan or advanced turboprop) may allow for the achievement of this objective by reducing engine fuel consumption. To evaluate the potential impact of open rotor engines, cycle modeling and engine weight estimation capabilities have been developed. The initial development of the cycle modeling capabilities in the Numerical Propulsion System Simulation (NPSS) tool was presented in a previous paper. Following that initial development, further advancements have been made to the cycle modeling and weight estimation capabilities for open rotor engines and are presented in this paper. The developed modeling capabilities are used to predict the performance of an advanced open rotor concept using modern counter-rotating propeller designs. Finally, performance and weight estimates for this engine are presented and compared to results from a previous NASA study of advanced geared and direct-drive turbofans.

Lexical Bundles in the Academic Writing of Advanced Chinese EFL Learners

ERIC Educational Resources Information Center

Wei, Yaoyu; Lei, Lei

2011-01-01

The present study investigated the use of lexical bundles in the academic writing of advanced Chinese EFL learners. A corpus of doctoral dissertations by the learners and a corpus of published journal articles by professional writers were collected for the study. Four-word lexical bundles in the two corpora were identified and analysed. Results…

The Strategic Study Group on the Status of Women: Report to the President and the Commission for Women--Recommendation Package #2.

ERIC Educational Resources Information Center

Pennsylvania State Univ., University Park.

The document presents partial recommendations of a Pennsylvania State University Study Group on the Status of Women at the University. Recommendations concern family-responsive and flexible employee benefits, clerical advancement and development, retention and advancement of women faculty, and sexual harassment of students. Among specific…

MEXICAN-AMERICAN STUDY PROJECT. ADVANCE REPORT 4, RESIDENTIAL SEGREGATION IN THE URBAN SOUTHWEST.

ERIC Educational Resources Information Center

MOORE, JOAN W.; AND OTHERS

THIS ADVANCE REPORT PRESENTS A STATISTICAL ANALYSIS OF THE DEGREE OF RESIDENTIAL SEGREGATION OF THE MEXICAN-AMERICAN AND NEGRO SUBPOPULATIONS FROM THE ANGLO SUBPOPULATIONS IN URBAN AREAS. ALL OF THE DATA WERE DRAWN FROM THE 1950 AND 1960 CENSUSES OF POPULATION AND HOUSING. FACTORS STUDIED INCLUDE URBANIZATION PATTERNS AND ORIGINS OF…

Experimental Design for Evaluating the Safety Benefits of Railroad Advance Warning Signs

DOT National Transportation Integrated Search

1979-04-01

The report presents the findings and conclusions of a study to develop an experimental design and analysis plan for field testing and evaluation of the accident reduction potential of a proposed new railroad grade crossing advance warning sign. Sever...

Advanced Traveler Information Service (ATIS) : private sector perceptions and public sector activities

DOT National Transportation Integrated Search

2000-01-01

This paper presents the results of a study by the United States Department of Transportation Volpe Center to determine the nature and extent of the data gap between the needs of private sector Advanced Traveler Information Service (ATIS) provid...

A study of the stress wave factor technique for evaluation of composite materials

NASA Technical Reports Server (NTRS)

Duke, J. C., Jr.; Henneke, E. G., II; Kiernan, M. T.; Grosskopf, P. P.

1989-01-01

The acousto-ultrasonic approach for nondestructive evaluation provides a measurement procedure for quantifying the integrated effect of globally distributed damage characteristic of fiber reinforced composite materials. The evaluation procedure provides a stress wave factor that correlates closely with several material performance parameters. The procedure was investigated for a variety of materials including advanced composites, hybrid structure bonds, adhesive bonds, wood products, and wire rope. The research program focused primarily on development of fundamental understanding and applications advancements of acousto-ultrasonics for materials characterization. This involves characterization of materials for which detection, location, and identification of imperfections cannot at present be analyzed satisfactorily with mechanical performance prediction models. In addition to presenting definitive studies on application potentials, the understanding of the acousto-ultrasonic method as applied to advanced composites is reviewed.

An integrated approach for prioritizing pharmaceuticals found in the environment for risk assessment, monitoring and advanced research.

PubMed

Caldwell, Daniel J; Mastrocco, Frank; Margiotta-Casaluci, Luigi; Brooks, Bryan W

2014-11-01

Numerous active pharmaceutical ingredients (APIs), approved prior to enactment of detailed environmental risk assessment (ERA) guidance in the EU in 2006, have been detected in surface waters as a result of advancements in analytical technologies. Without adequate knowledge of the potential hazards these APIs may pose, assessing their environmental risk is challenging. As it would be impractical to commence hazard characterization and ERA en masse, several approaches to prioritizing substances for further attention have been published. Here, through the combination of three presentations given at a recent conference, "Pharmaceuticals in the Environment, Is there a problem?" (Nîmes, France, June 2013) we review several of these approaches, identify salient components, and present available techniques and tools that could facilitate a pragmatic, scientifically sound approach to prioritizing APIs for advanced study or ERA and, where warranted, fill critical data gaps through targeted, intelligent testing. We further present a modest proposal to facilitate future prioritization efforts and advanced research studies that incorporates mammalian pharmacology data (e.g., adverse outcomes pathways and the fish plasma model) and modeled exposure data based on pharmaceutical use. Copyright © 2014 Elsevier Ltd. All rights reserved.

Behavior of thin-walled beams made of advanced composite materials and incorporating non-classical effects

NASA Astrophysics Data System (ADS)

Librescu, Liviu; Song, Ohseop

1991-11-01

Several results concerning the refined theory of thin-walled beams of arbitrary closed cross-section incorporating nonclassical effects are presented. These effects are related both with the exotic properties characterizing the advanced composite material structures and the nonuniform torsional model. A special case of the general equations is used to study several problems of cantilevered thin-walled beams and to assess the influence of the incorporated effects. The results presented in this paper could be useful toward a more rational design of aeronautical or aerospace constructions, as well as of helicopter or tilt rotor blades constructed of advanced composite materials.

Advanced spacecraft thermal control techniques

NASA Technical Reports Server (NTRS)

Fritz, C. H.

1977-01-01

The problems of rejecting large amounts of heat from spacecraft were studied. Shuttle Space Laboratory heat rejection uses 1 kW for pumps and fans for every 5 kW (thermal) heat rejection. This is rather inefficient, and for future programs more efficient methods were examined. Two advanced systems were studied and compared to the present pumped-loop system. The advanced concepts are the air-cooled semipassive system, which features rejection of a large percentage of the load through the outer skin, and the heat pipe system, which incorporates heat pipes for every thermal control function.

An overview of key technology thrusts at Bell Helicopter Textron

NASA Technical Reports Server (NTRS)

Harse, James H.; Yen, Jing G.; Taylor, Rodney S.

1988-01-01

Insight is provided into several key technologies at Bell. Specific topics include the results of ongoing research and development in advanced rotors, methodology development, and new configurations. The discussion on advanced rotors highlight developments on the composite, bearingless rotor, including the development and testing of full scale flight hardware as well as some of the design support analyses and verification testing. The discussion on methodology development concentrates on analytical development in aeromechanics, including correlation studies and design application. New configurations, presents the results of some advanced configuration studies including hardware development.

Beyond Airmindedness: Managing Regional Affairs Strategists for Joint Strategic Effect

DTIC Science & Technology

2017-06-01

FORCE A THESIS PRESENTED TO THE FACULTY OF THE SCHOOL OF ADVANCED AIR AND SPACE STUDIES FOR COMPLETION OF GRADUATION REQUIREMENTS SCHOOL OF...Strategy and Security Studies at the School of Advanced Air and Space Studies, for his review of the final draft and suggestions for improvement...Our forces must have the ability to effectively communicate with and understand the cultures of coalition forces, international partners, and local

The Next Step: A Study on Resiliency in Command and Control

DTIC Science & Technology

2015-06-01

THE NEXT STEP: A STUDY ON RESILIENCY IN COMMAND AND CONTROL” BY LT COL RUSS “BONES” COOK A THESIS PRESENTED TO THE FACULTY OF THE SCHOOL...OF ADVANCED AIR AND SPACE STUDIES FOR COMPLETION OF GRADUATION REQUIREMENTS SCHOOL OF ADVANCED AIR AND SPACE STUDIES AIR UNIVERSITY MAXWELL...Aeronautical University; MA, Military Studies , Marine Corps University) is a senior pilot with more than 2,500 hours including combat time in both the HH

Recent advances in vacuum sciences and applications

NASA Astrophysics Data System (ADS)

Mozetič, M.; Ostrikov, K.; Ruzic, D. N.; Curreli, D.; Cvelbar, U.; Vesel, A.; Primc, G.; Leisch, M.; Jousten, K.; Malyshev, O. B.; Hendricks, J. H.; Kövér, L.; Tagliaferro, A.; Conde, O.; Silvestre, A. J.; Giapintzakis, J.; Buljan, M.; Radić, N.; Dražić, G.; Bernstorff, S.; Biederman, H.; Kylián, O.; Hanuš, J.; Miloševič, S.; Galtayries, A.; Dietrich, P.; Unger, W.; Lehocky, M.; Sedlarik, V.; Stana-Kleinschek, K.; Drmota-Petrič, A.; Pireaux, J. J.; Rogers, J. W.; Anderle, M.

2014-04-01

Recent advances in vacuum sciences and applications are reviewed. Novel optical interferometer cavity devices enable pressure measurements with ppm accuracy. The innovative dynamic vacuum standard allows for pressure measurements with temporal resolution of 2 ms. Vacuum issues in the construction of huge ultra-high vacuum devices worldwide are reviewed. Recent advances in surface science and thin films include new phenomena observed in electron transport near solid surfaces as well as novel results on the properties of carbon nanomaterials. Precise techniques for surface and thin-film characterization have been applied in the conservation technology of cultural heritage objects and recent advances in the characterization of biointerfaces are presented. The combination of various vacuum and atmospheric-pressure techniques enables an insight into the complex phenomena of protein and other biomolecule conformations on solid surfaces. Studying these phenomena at solid-liquid interfaces is regarded as the main issue in the development of alternative techniques for drug delivery, tissue engineering and thus the development of innovative techniques for curing cancer and cardiovascular diseases. A review on recent advances in plasma medicine is presented as well as novel hypotheses on cell apoptosis upon treatment with gaseous plasma. Finally, recent advances in plasma nanoscience are illustrated with several examples and a roadmap for future activities is presented.

77 FR 47078 - 2012 Parenteral Drug Association/Food and Drug Administration Joint Regulatory Conference...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-07

... of today's leading pharmaceutical companies present case studies on how they employ global strategies... Through Quality Systems: Implementing and Advancing a Sustainable Global Quality Culture AGENCY: Food and... entitled ``Compliance Through Quality Systems: Implementing and Advancing a Sustainable Global Quality...

Advanced Tools Webinar Series Presents: Regulatory Issues and Case Studies of Advanced Tools

EPA Science Inventory

U.S. EPA has released A Guide for Assessing Biodegradation and Source Identification of Organic Ground Water Contaminants using Compound Specific Isotope Analysis (CSIA) [EPA 600/R-08/148 | December 2008 | www.epa.gov/ada]. The Guide provides recommendations for sample collecti...

Advanced missions safety. Volume 2: Technical discussion, Part 2: Experiment safety, guidelines

NASA Technical Reports Server (NTRS)

Hinton, M. G., Jr.

1972-01-01

A technical analysis of a portion of the advanced missions safety study is presented. The potential hazards introduced when experimental equipment is carried aboard the Earth Orbit Shuttle are identified. Safety guidelines and requirements for eliminating or reducing these hazards are recommended.

Advanced protein crystal growth programmatic sensitivity study

NASA Technical Reports Server (NTRS)

1992-01-01

The purpose of this study is to define the costs of various APCG (Advanced Protein Crystal Growth) program options and to determine the parameters which, if changed, impact the costs and goals of the programs and to what extent. This was accomplished by developing and evaluating several alternate programmatic scenarios for the microgravity Advanced Protein Crystal Growth program transitioning from the present shuttle activity to the man tended Space Station to the permanently manned Space Station. These scenarios include selected variations in such sensitivity parameters as development and operational costs, schedules, technology issues, and crystal growth methods. This final report provides information that will aid in planning the Advanced Protein Crystal Growth Program.

Overview on NASA's Advanced Electric Propulsion Concepts Activities

NASA Technical Reports Server (NTRS)

Frisbee, Robert H.

1999-01-01

Advanced electric propulsion research activities are currently underway that seek to addresses feasibility issues of a wide range of advanced concepts, and may result in the development of technologies that will enable exciting new missions within our solar system and beyond. Each research activity is described in terms of the present focus and potential future applications. Topics include micro-electric thrusters, electrodynamic tethers, high power plasma thrusters and related applications in materials processing, variable specific impulse plasma thrusters, pulsed inductive thrusters, computational techniques for thruster modeling, and advanced electric propulsion missions and systems studies.

Preliminary Sizing of 120-Passenger Advanced Civil Rotorcraft Concepts

NASA Technical Reports Server (NTRS)

vanAken, Johannes M.; Sinsay, Jeffrey D.

2006-01-01

The results of a preliminary sizing study of advanced civil rotorcraft concepts that are capable of carrying 120 passengers over a range of 1,200 nautical miles are presented. The cruise altitude of these rotorcraft is 30,000 ft and the cruise velocity is 350 knots. The mission requires a hover capability, creating a runway independent solution, which might aid in reducing strain on the existing airport infrastructure. Concepts studied are a tiltrotor, a tandem rotor compound, and an advancing blade concept. The first objective of the study is to determine the relative merits of these designs in terms of mission gross weight, engine size, fuel weight, aircraft purchase price, and direct operating cost. The second objective is to identify the enabling technology for these advanced heavy lift civil rotorcraft.

Advanced practice nursing students' knowledge, self-efficacy, and attitudes related to depression in older adults: teaching holistic depression care.

PubMed

Delaney, Colleen; Barrere, Cynthia

2012-01-01

The aim of this study was to examine the knowledge, attitudes, and self-efficacy of advanced practice nursing students toward depression in older adults. Findings suggest that advanced practice nursing students are interested in caring for the whole person and desired more information on the physical and emotional-spiritual needs of older patients with depression. Suggestions for holistic nursing depression care education are presented.

[Technology development as social process: prospects and frontiers of social scientific elucidation of technological advancement].

PubMed

Dierkes, M

1990-05-01

This article provides an overview of the new developments in social scientific technology research which have changed considerably as a result of public debate and reactions to the importance of advancements in technology. The shift in emphasis, away from the effects of technology to its shaping, is described and certain hypotheses and concepts of advancement in the study of the social conditions underlying technical development processes are presented.

Case Studies in Regional Energy Planning. Papers presented at a symposium at the Annual Meeting of the American Association for the Advancement of Science (142nd, Boston, Massachusetts, February 18-24, 1976).

ERIC Educational Resources Information Center

Blanpied, William A., Ed.; Vermilye, Gretchen, Ed.

The papers reproduced in this collection were originally prepared for presentation at a February 1976 symposium at the annual meeting of the American Association for the Advancement of Science. The symposium summarized a series of three regional seminars on National Energy Policy in a Regional Context; these seminars were held in Minnesota, New…

Presentations of the Ninth Advanced Communications Technology Satellite Propagation Studies Workshop (APSW IX)

NASA Technical Reports Server (NTRS)

Golshan, Nasser (Editor)

1997-01-01

The Advanced Communications Technology Satellite Propagation Studies Workshop (APSW) is convened each year to present the results of the ACTS Propagation Campaign. Representatives from the satellite communications (satcom) industry, academia, and government are invited to APSW for discussions and exchange of information. The ACTS Propagation campaign is completing three years of Ka-Band data collection at seven sites in North America. Through this effort, NASA is making a major contribution to growth of satcom services by providing timely propagation data and models for predicting the performance of Ka-Band satellite communications systems.

Phonological Advance Planning in Sentence Production

ERIC Educational Resources Information Center

Oppermann, Frank; Jescheniak, Jorg D.; Schriefers, Herbert

2010-01-01

Our study addresses the scope of phonological advance planning during sentence production using a novel experimental procedure. The production of German sentences in various syntactic formats (SVO, SOV, and VSO) was cued by presenting pictures of the agents of previously memorized agent-action-patient scenes. To tap the phonological activation of…

Making It Personal: Performance-Based Assessments, Ubiquitous Technology, and Advanced Learners

ERIC Educational Resources Information Center

Arispe, Kelly; Burston, Jack

2017-01-01

This pedagogical implementation study advocates for performance-driven assessments to help learners become aware of and improve upon presentational speaking skills at the advanced level. A social media content creation tool, Adobe Spark Video, enabled learners to practice oral skills outside of class. The task design, implementation, and…

Advanced Vehicle Concepts and Implications for NextGen

NASA Technical Reports Server (NTRS)

Blake, Matt; Smith, Jim; Wright, Ken; Mediavilla Ricky; Kirby, Michelle; Pfaender, Holger; Clarke, John-Paul; Volovoi, Vitali; Dorbian, Christopher; Ashok, Akshay;

Pain experiences of patients with advanced cancer: A qualitative descriptive study.

PubMed

Erol, Ozgul; Unsar, Serap; Yacan, Lale; Pelin, Meryem; Kurt, Seda; Erdogan, Bülent

2018-04-01

Uncontrolled pain, especially in patients with advanced cancer, affects quality of life negatively and causes negative physical and psychological conditions. The aim of this study was to explore the pain experiences of patients with advanced cancer and how they manage with pain, and to present a view of pain management approaches of nurses from the perspectives of the patients. This was a qualitative descriptive study of sixteen hospitalized patients with advanced cancer. Data were collected using semi-structured interviews with patients. Data were analysed by Colaizzi's phenomenological method. This study found that patients with advanced cancer who had pain experienced anxiety, helplessness, hopelessness and many restrictions in daily life as well as inability to manage with pain. Most of the patients with advanced cancer were not satisfied with their nursing care with regard to pain management. The themes that emerged were pain perception and experiences, effects of pain on daily life, pain management and management strategies and the patients' perspectives about nursing approaches to pain. This study demonstrated the difficulties of patients with advanced cancer who experienced pain in their daily lives, yet lack pain management strategies. Furthermore, nurses' caring approaches to patients with advanced cancer who experienced pain was found inadequate. Oncology nurses should provide educational interventions in order to enhance knowledge and skills about pain assessment and non-pharmacologic and pharmacologic strategies used in pain management. Copyright © 2018 Elsevier Ltd. All rights reserved.

Example-based learning: effects of model expertise in relation to student expertise.

PubMed

Boekhout, Paul; van Gog, Tamara; van de Wiel, Margje W J; Gerards-Last, Dorien; Geraets, Jacques

2010-12-01

Worked examples are very effective for novice learners. They typically present a written-out ideal (didactical) solution for learners to study. This study used worked examples of patient history taking in physiotherapy that presented a non-didactical solution (i.e., based on actual performance). The effects of model expertise (i.e., worked example based on advanced, third-year student model or expert physiotherapist model) in relation to students' expertise (i.e., first- or second-year) were investigated. One hundred and thirty-four physiotherapy students (61 first-year and 73 second-year). Design was 2 × 2 factorial with factors 'Student Expertise' (first-year vs. second-year) and 'Model Expertise' (expert vs. advanced student). Within expertise levels, students were randomly assigned to the Expert Example or the Advanced Student Example condition. All students studied two examples (content depending on their assigned condition) and then completed a retention and test task. They rated their invested mental effort after each example and test task. Second-year students invested less mental effort in studying the examples, and in performing the retention and transfer tasks than first-year students. They also performed better on the retention test, but not on the transfer test. In contrast to our hypothesis, there was no interaction between student expertise and model expertise: all students who had studied the Expert examples performed better on the transfer test than students who had studied Advanced Student Examples. This study suggests that when worked examples are based on actual performance, rather than an ideal procedure, expert models are to be preferred over advanced student models.

Branding Icarus: The Construction of Identity and Diversity at The United States Air Force Academy

DTIC Science & Technology

2015-06-01

Government-sponsored research , prompting the question: “Why study the military if the result of investigations can be utilized by armed forces to...Gradu- ates (Colorado Springs, CO: HQ USAFA Institutional Research and Assessment Division, 2005), 71 social studies .11 There are also gaps...PRESENTED TO THE FACULTY OF THE SCHOOL OF ADVANCED AIR AND SPACE STUDIES FOR COMPLETION OF GRADUATION REQUIREMENTS SCHOOL OF ADVANCED AIR AND

A Game of Cat and Mouse: Intelligence and Dynamic Targeting in Operation Allied Force

DTIC Science & Technology

2017-06-01

PRESENTED TO THE FACULTY OF THE SCHOOL OF ADVANCED AIR AND SPACE STUDIES FOR COMPLETION OF GRADUATION REQUIREMENTS SCHOOL OF ADVANCED AIR...AND SPACE STUDIES AIR UNIVERSITY MAXWELL AIR FORCE BASE, ALABAMA JUNE 2017 DISTRIBUTION A. Approved for public release: distribution...want to thank Major General Glen Shaffer who initially planted the seed for the idea of this study while serving as a senior mentor for the

The Reception Learning Paradigm.

ERIC Educational Resources Information Center

Novak, Joseph D.

1979-01-01

Presented is a paradigm for science education research. The paradigm advances the reception learning theory, where regularities to be learned are presented explicitly to the learner. A tool for the study of knowledge production in science education, the Gowin "V," is presented. (RE)

PREFACE: International Scientific Conference of Young Scientists: Advanced Materials in Construction and Engineering (TSUAB2014)

NASA Astrophysics Data System (ADS)

Kopanitsa, Natalia O.

2015-01-01

In October 15-17, 2014 International Scientific Conference of Young Scientists: Advanced Materials in Construction and Engineering (TSUAB2014) took place at Tomsk State University of Architecture and Building (Tomsk, Russia). The Conference became a discussion platform for researchers in the fields of studying structure and properties of advanced building materials and included open lectures of leading scientists and oral presentations of master, postgraduate and doctoral students. A special session was devoted to reports of school children who further plan on starting a research career. The Conference included an industrial exhibition where companies displayed the products and services they supply. The companies also gave presentations of their products within the Conference sessions.

The effects of regional insolation differences upon advanced solar thermal electric power plant performance and energy costs

NASA Technical Reports Server (NTRS)

Latta, A. F.; Bowyer, J. M.; Fujita, T.

1979-01-01

This paper presents the performance and cost of four 10-MWe advanced solar thermal electric power plants sited in various regions of the continental United States. Each region has different insolation characteristics which result in varying collector field areas, plant performance, capital costs, and energy costs. The paraboloidal dish, central receiver, cylindrical parabolic trough, and compound parabolic concentrator (CPC) comprise the advanced concepts studied. This paper contains a discussion of the regional insolation data base, a description of the solar systems' performances and costs, and a presentation of a range for the forecast cost of conventional electricity by region and nationally over the next several decades.

Chyle fistula in advanced and metastatic thyroid cancer.

PubMed

Duque, Carlos S; Sánchez, Juan Guillermo; Dionigi, Gianlorenzo

2017-10-01

Chyle fistula (CF) is a rare but challenging condition for the surgeon and the patient's health. A retrospective review of single surgeon's case load in a 12-year period is presented, reviewing the case of those patients presenting with a CF. Three patients were found during this study period from more than 1,050 surgeries performed due to thyroid cancer. Patients underwent extensive lymph node dissection for advanced, metastatic and infiltrative disease. In all patients, a long hospital stay and surgical re-interventions were required. A description of the management of CF is presented along with a review of current Literature.

An arousing, musically enhanced bird song stimulus mediates circadian rhythm phase advances in dim light.

PubMed

Goel, Namni

2006-09-01

A musically enhanced bird song stimulus presented in the early subjective night phase delays human circadian rhythms. This study determined the phase-shifting effects of the same stimulus in the early subjective day. Eleven subjects (ages 18-63 yr; mean +/- SD: 28.0 +/- 16.6 yr) completed two 4-day laboratory sessions in constant dim light (<20 lux). They received two consecutive presentations of either a 2-h musically enhanced bird song or control stimulus from 0600 to 0800 on the second and third mornings while awake. The 4-day sessions employing either the stimulus or control were counterbalanced. Core body temperature (CBT) was collected throughout the study, and salivary melatonin was obtained every 30 min from 1900 to 2330 on the baseline and poststimulus/postcontrol nights. Dim light melatonin onset and CBT minimum circadian phase before and after stimulus or control presentation was assessed. The musically enhanced bird song stimulus produced significantly larger phase advances of the circadian melatonin (mean +/- SD: 0.87 +/- 0.36 vs. 0.24 +/- 0.22 h) and CBT (1.08 +/- 0.50 vs. 0.43 +/- 0.37 h) rhythms than the control. The stimulus also decreased fatigue and total mood disturbance, suggesting arousing effects. This study shows that a musically enhanced bird song stimulus presented during the early subjective day phase advances circadian rhythms. However, it remains unclear whether the phase shifts are due directly to effects of the stimulus on the clock or are arousal- or dim light-mediated effects. This nonphotic stimulus mediates circadian resynchronization in either the phase advance or delay direction.

Advanced continuously variable transmissions for electric and hybrid vehicles

NASA Technical Reports Server (NTRS)

Loewenthal, S. H.

1980-01-01

A brief survey of past and present continuously variable transmissions (CVT) which are potentially suitable for application with electric and hybrid vehicles is presented. Discussion of general transmission requirements and benefits attainable with a CVT for electric vehicle use is given. The arrangement and function of several specific CVT concepts are cited along with their current development status. Lastly, the results of preliminary design studies conducted under a NASA contract for DOE on four CVT concepts for use in advanced electric vehicles are reviewed.

Study of flutter related computational procedures for minimum weight structural sizing of advanced aircraft

NASA Technical Reports Server (NTRS)

Oconnell, R. F.; Hassig, H. J.; Radovcich, N. A.

1976-01-01

Results of a study of the development of flutter modules applicable to automated structural design of advanced aircraft configurations, such as a supersonic transport, are presented. Automated structural design is restricted to automated sizing of the elements of a given structural model. It includes a flutter optimization procedure; i.e., a procedure for arriving at a structure with minimum mass for satisfying flutter constraints. Methods of solving the flutter equation and computing the generalized aerodynamic force coefficients in the repetitive analysis environment of a flutter optimization procedure are studied, and recommended approaches are presented. Five approaches to flutter optimization are explained in detail and compared. An approach to flutter optimization incorporating some of the methods discussed is presented. Problems related to flutter optimization in a realistic design environment are discussed and an integrated approach to the entire flutter task is presented. Recommendations for further investigations are made. Results of numerical evaluations, applying the five methods of flutter optimization to the same design task, are presented.

System architecture for an advanced Canadian communications satellite demonstration mission

NASA Astrophysics Data System (ADS)

Takats, P.; Irani, S.

1992-03-01

An advanced communications satellite system that provides single hop interconnectivity and interworking for both a personal communications network and an advanced private business network in the Ka and Ku bands respectively, is presented. An overall network perspective is discussed that studies the interface of such an advanced satellite communication system to the terrestrial network in the context of the Open Systems Interconnection model. It is shown that this proposed satellite system can dynamically establish links and efficiently allocate the satellite resource amongst the user terminal population for a mix of data and voice traffic.

Advanced energy storage for space applications: A follow-up

NASA Technical Reports Server (NTRS)

Halpert, Gerald; Surampudi, Subbarao

1994-01-01

Viewgraphs on advanced energy storage for space applications are presented. Topics covered include: categories of space missions using batteries; battery challenges; properties of SOA and advanced primary batteries; lithium primary cell applications; advanced rechargeable battery applications; present limitations of advanced battery technologies; and status of Li-TiS2, Ni-MH, and Na-NiCl2 cell technologies.

How Syntactic Reasoners Can Develop Understanding, Evaluate Conjectures, and Generate Counterexamples in Advanced Mathematics

ERIC Educational Resources Information Center

Weber, Keith

2009-01-01

This paper presents a case study of a highly successful student whose exploration of an advanced mathematical concept relies predominantly on syntactic reasoning, such as developing formal representations of mathematical ideas and making logical deductions. This student is observed as he learns a new mathematical concept and then completes…

When Prior Knowledge Interferes, Inhibitory Control Matters for Learning: The Case of Numerical Magnitude Representations

ERIC Educational Resources Information Center

Laski, Elida V.; Dulaney, Alana

2015-01-01

The present study tested the "interference hypothesis"-that learning and using more advanced representations and strategies requires the inhibition of prior, less advanced ones. Specifically, it examined the relation between inhibitory control and number line estimation performance. Experiment 1 compared the accuracy of adults' (N = 53)…

Informal Content and Student Note-Taking in Advanced Mathematics Classes

ERIC Educational Resources Information Center

Fukawa-Connelly, Timothy; Weber, Keith; Mejía-Ramos, Juan Pablo

2017-01-01

This study investigates 3 hypotheses about proof-based mathematics instruction: (a) that lectures include informal content (ways of thinking and reasoning about advanced mathematics that are not captured by formal symbolic statements), (b) that informal content is usually presented orally but not written on the board, and (c) that students do not…

Computer program user's manual for advanced general aviation propeller study

NASA Technical Reports Server (NTRS)

Worobel, R.

1972-01-01

A user's manual is presented for a computer program for predicting the performance (static, flight, and reverse), noise, weight and cost of propellers for advanced general aviation aircraft of the 1980 time period. Complete listings of this computer program with detailed instructions and samples of input and output are included.

Advancing Humanities Studies at Community, Technical, and Junior Colleges.

ERIC Educational Resources Information Center

Eisenberg, Diane U.; And Others

The American Association of Community and Junior Colleges' (AACJC's) two-year Advancing the Humanities Project (AHP) has assisted selected community colleges in promoting the humanities on their campuses. Parts I and II of this report on the AHP present statements by Dale Parnell and Judith Jeffrey Howard about the AACJC's humanities initiatives…

Strategic Leadership: A Model for Promoting, Sustaining, and Advancing Institutional Significance

ERIC Educational Resources Information Center

Scott, Kenneth E.; Johnson, Mimi

2011-01-01

This article presents the methods, materials, and manpower required to create a strategic leadership program for promoting, sustaining, and advancing institutional significance. The functionality of the program is based on the Original Case Study Design (OCSD) methodology, in which participants are given actual college issues to investigate from a…

The Role of Receptive Vocabulary Knowledge in Advanced EFL Listening Comprehension

ERIC Educational Resources Information Center

Atas, Ufuk

2018-01-01

This paper presents an empirical study that investigates the role of vocabulary knowledge in listening comprehension with 33 advanced Turkish learners of English as a foreign language. The Vocabulary Levels Test (Schmitt, Schmitt & Clapham, 2001) is used to measure the vocabulary knowledge of the participants and a standardized listening test…

Advanced data management for optimising the operation of a full-scale WWTP.

PubMed

Beltrán, Sergio; Maiza, Mikel; de la Sota, Alejandro; Villanueva, José María; Ayesa, Eduardo

2012-01-01

The lack of appropriate data management tools is presently a limiting factor for a broader implementation and a more efficient use of sensors and analysers, monitoring systems and process controllers in wastewater treatment plants (WWTPs). This paper presents a technical solution for advanced data management of a full-scale WWTP. The solution is based on an efficient and intelligent use of the plant data by a standard centralisation of the heterogeneous data acquired from different sources, effective data processing to extract adequate information, and a straightforward connection to other emerging tools focused on the operational optimisation of the plant such as advanced monitoring and control or dynamic simulators. A pilot study of the advanced data manager tool was designed and implemented in the Galindo-Bilbao WWTP. The results of the pilot study showed its potential for agile and intelligent plant data management by generating new enriched information combining data from different plant sources, facilitating the connection of operational support systems, and developing automatic plots and trends of simulated results and actual data for plant performance and diagnosis.

Biological Features of the Soil: Advanced Crop and Soil Science. A Course of Study.

ERIC Educational Resources Information Center

Miller, Larry E.

The course of study represents the third of six modules in advanced crop and soil science and introduces the agriculture student to biological features of soil. Upon completing the two day lesson, the student will: (1) realize the vast amount of life present in the soil, (2) be able to list representative animal and plant life in the soil by size,…

The Advanced Gamma-ray Imaging System (AGIS): Simulation Studies

NASA Astrophysics Data System (ADS)

Fegan, Stephen; Buckley, J. H.; Bugaev, S.; Funk, S.; Konopelko, A.; Maier, G.; Vassiliev, V. V.; Simulation Studies Working Group; AGIS Collaboration

2008-03-01

The Advanced Gamma-ray Imaging System (AGIS) is a concept for the next generation instrument in ground-based very high energy gamma-ray astronomy. It has the goal of achieving significant improvement in sensitivity over current experiments. We present the results of simulation studies of various possible designs for AGIS. The primary characteristics of the array performance, collecting area, angular resolution, background rejection, and sensitivity are discussed.

Metal hydride hydrogen compression: recent advances and future prospects

NASA Astrophysics Data System (ADS)

Yartys, Volodymyr A.; Lototskyy, Mykhaylo; Linkov, Vladimir; Grant, David; Stuart, Alastair; Eriksen, Jon; Denys, Roman; Bowman, Robert C.

2016-04-01

Metal hydride (MH) thermal sorption compression is one of the more important applications of the MHs. The present paper reviews recent advances in the field based on the analysis of the fundamental principles of this technology. The performances when boosting hydrogen pressure, along with two- and three-step compression units, are analyzed. The paper includes also a theoretical modelling of a two-stage compressor aimed at describing the performance of the experimentally studied systems, their optimization and design of more advanced MH compressors. Business developments in the field are reviewed for the Norwegian company HYSTORSYS AS and the South African Institute for Advanced Materials Chemistry. Finally, future prospects are outlined presenting the role of the MH compression in the overall development of the hydrogen-driven energy systems. The work is based on the analysis of the development of the technology in Europe, USA and South Africa.

Metal hydride hydrogen compression: Recent advances and future prospects

DOE PAGES

Bowman, Jr., Robert C.; Yartys, Volodymyr A.; Lototskyy, Mykhaylo V.; ...

2016-03-17

Metal hydride (MH) thermal sorption compression is one of the more important applications of the metal hydrides. The present paper reviews recent advances in the field based on the analysis of the fundamental principles of this technology. The performances when boosting hydrogen pressure, along with two- and three-step compression units are analyzed. The paper includes also a theoretical modeling of a two-stage compressor aimed at both describing the performance of the experimentally studied systems, but, also, on their optimization and design of more advanced MH compressors. Business developments in the field are reviewed for the Norwegian company HYSTORSYS AS andmore » the South African Institute for Advanced Materials Chemistry. Finally, future prospects are outlined presenting the role of the metal hydride compression in the overall development of the hydrogen driven energy systems. Lastly, the work is based on the analysis of the development of the technology in Europe, USA and South Africa.« less

Predicting Mathematical Aptitude for Higher Education

ERIC Educational Resources Information Center

McDonald, Betty

2008-01-01

This present study seeks to predict mathematical aptitude for higher education by examining the relationship between mathematics results from the Caribbean Examinations Council (CXC) general proficiency examination and the results from the General Certificate of Education (GCE) advanced level examination. This present study arose from a more…

Solar System Exploration Augmented by In-Situ Resource Utilization: Human Mercury and Saturn Exploration

NASA Technical Reports Server (NTRS)

Palaszewski, Bryan

2015-01-01

Human and robotic missions to Mercury and Saturn are presented and analyzed. Unique elements of the local planetary environments are discussed and included in the analyses and assessments. Using historical studies of space exploration, in-situ resource utilization (ISRU), and industrialization all point to the vastness of natural resources in the solar system. Advanced propulsion benefitted from these resources in many way. While advanced propulsion systems were proposed in these historical studies, further investigation of nuclear options using high power nuclear thermal and nuclear pulse propulsion as well as advanced chemical propulsion can significantly enhance these scenarios. Updated analyses based on these historical visions will be presented. Nuclear thermal propulsion and ISRU enhanced chemical propulsion landers are assessed for Mercury missions. At Saturn, nuclear pulse propulsion with alternate propellant feed systems and Titan exploration with chemical propulsion options are discussed.

A review of advanced turboprop transport aircraft

NASA Astrophysics Data System (ADS)

Lange, Roy H.

The application of advanced technologies shows the potential for significant improvement in the fuel efficiency and operating costs of future transport aircraft envisioned for operation in the 1990s time period. One of the more promising advanced technologies is embodied in an advanced turboprop concept originated by Hamilton Standard and NASA and known as the propfan. The propfan concept features a highly loaded multibladed, variable pitch propeller geared to a high pressure ratio gas turbine engine. The blades have high sweepback and advanced airfoil sections to achieve 80 percent propulsive efficiency at M=0.80 cruise speed. Aircraft system studies have shown improvements in fuel efficiency of 15-20 percent for propfan advanced transport aircraft as compared to equivalent turbofan transports. Beginning with the Lockheed C-130 and Electra turboprop aircraft, this paper presents an overview of the evolution of propfan aircraft design concepts and system studies. These system studies include possible civil and military transport applications and data on the performance, community and far-field noise characteristics and operating costs of propfan aircraft design concepts. NASA Aircraft Energy Efficiency (ACEE) program propfan projects with industry are reviewed with respect to system studies of propfan aircraft and recommended flight development programs.

Home parenteral nutrition for advanced cancer patients: Contributes to survival?

PubMed

Theilla, Miriam; Cohen, Johnathan; Kagan, Ilia; Attal-Singer, Joelle; Lev, Shaul; Singer, Pierre

2017-03-24

Patients with advanced cancer often suffer from severe malnutrition and gastrointestinal obstruction. This population could benefit from home parenteral nutrition (HPN). The aim of this study was to observe the outcome of patients with advanced cancer patients who were eligible for HPN. All patients in the nutrition clinic who received HPN over the past 7 y were included in the present study. We compared patients with advanced cancer with the noncancer population in terms of hospitalization rate and mortality. Of 221 advanced cancer patients, 153 who had no oral/enteral intake and who received HPN survived. Of these, 35% survived for 6 mo, 27% for 1 y, 18.9% survived 2 y, and 3.9% survived for the 7 y of the follow-up. Hospitalization rate was not significantly different from the noncancer population. These results show that HPN is a relevant palliative therapy for patients with advanced cancer patients without oral or enteral feeding access. Copyright © 2017 Elsevier Inc. All rights reserved.

The consequences of using advanced physical assessment skills in medical and surgical nursing: A hermeneutic pragmatic study.

PubMed

Zambas, Shelaine I; Smythe, Elizabeth A; Koziol-Mclain, Jane

2016-01-01

The aim of this study was to explore the consequences of the nurse's use of advanced assessment skills on medical and surgical wards. Appropriate, accurate, and timely assessment by nurses is the cornerstone of maintaining patient safety in hospitals. The inclusion of "advanced" physical assessment skills such as auscultation, palpation, and percussion is thought to better prepare nurses for complex patient presentations within a wide range of clinical situations. This qualitative study used a hermeneutic pragmatic approach. Unstructured interviews were conducted with five experienced medical and surgical nurses to obtain 13 detailed narratives of assessment practice. Narratives were analyzed using Van Manen's six-step approach to identify the consequences of the nurse's use of advanced assessment skills. The consequences of using advanced assessment skills include looking for more, challenging interpretations, and perseverance. The use of advanced assessment skills directs what the nurse looks for, what she sees, interpretation of the findings, and her response. It is the interpretation of what is seen, heard, or felt within the full context of the patient situation, which is the advanced skill. Advanced assessment skill is the means to an accurate interpretation of the clinical situation and contributes to appropriate diagnosis and medical management in complex patient situations. The nurse's use of advanced assessment skills enables her to contribute to diagnostic reasoning within the acute medical and surgical setting.

[Research advances in dendrochronology].

PubMed

Fang, Ke-Yan; Chen, Qiu-Yan; Liu, Chang-Zhi; Cao, Chun-Fu; Chen, Ya-Jun; Zhou, Fei-Fei

2014-07-01

Tree-ring studies in China have achieved great advances since the 1990s, particularly for the dendroclimatological studies which have made some influence around the world. However, because of the uneven development, limited attention has been currently paid on the other branches of dendrochronology. We herein briefly compared the advances of dendrochronology in China and of the world and presented suggestions on future dendrochronological studies. Large-scale tree-ring based climate reconstructions in China are highly needed by employing mathematical methods and a high quality tree-ring network of the ring-width, density, stable isotope and wood anatomy. Tree-ring based field climate reconstructions provide potentials on explorations of climate forcings during the reconstructed periods via climate diagnosis and process simulation.

10-year survival rate and the incidence of peri-implant disease of 374 titanium dental implants with a SLA surface: a prospective cohort study in 177 fully and partially edentulous patients.

PubMed

van Velzen, Frank J J; Ofec, Ronen; Schulten, Engelbert A J M; Ten Bruggenkate, Christiaan M

2015-10-01

This prospective cohort study evaluates the 10-year survival and incidence of peri-implant disease at implant and patient level of sandblasted, large grid, and acid-etched titanium dental implants (Straumann, soft tissue level, SLA surface) in fully and partially edentulous patients. Patients who had dental implant surgery in the period between November 1997 and June 2001, with a follow-up of at least 10 years, were investigated for clinical and radiological examination. Among the 506 inserted dental implants in 250 patients, 10-year data regarding the outcome of implants were available for 374 dental implants in 177 patients. In the current study, peri-implantitis was defined as advanced bone loss (≧1.5 mm. postloading) in combination with bleeding on probing. At 10-year follow-up, only one implant was lost (0.3%) 2 months after implant surgery due to insufficient osseointegration. The average bone loss at 10 year postloading was 0.52 mm. Advanced bone loss at 10-year follow-up was present in 35 dental implants (9.8%). Seven percent of the observed dental implants showed bleeding on probing in combination with advanced bone loss and 4.2% when setting the threshold for advanced bone loss at 2.0 mm. Advanced bone loss without bleeding on probing was present in 2.8% of all implants. In this prospective study, the 10-year survival rate at implant and patient level was 99.7% and 99.4%, respectively. Peri-implantitis was present in 7% of the observed dental implants according to the above-mentioned definition of peri-implantitis. This study shows that SLA implants offer predictable long-term results as support in the treatment of fully and partially edentulous patients. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Advancing automation and robotics technology for the Space Station Freedom and for the US economy

NASA Technical Reports Server (NTRS)

1990-01-01

In April 1985, the NASA Advanced Technology Advisory Committee (ATAC) reported to Congress the results of its studies on advanced automation and robotics technology for use on Space Station Freedom. This material was documented in the initial report (NASA Technical Memorandum 87566). The progress made by Levels 1, 2, and 3 of the Office of Space Station in developing and applying advanced automation and robotics technology are described. Emphasis was placed upon the Space Station Freedom Program responses to specific recommendations made in ATAC Progress Report 9, the Flight Telerobotic Servicer, the Advanced Development Program, and the Data Management System. Assessments are presented for these and other areas as they apply to the advancement of automation and robotics technology for the Space Station Freedom.

Older adults’ attitudes toward noncompetent subjects participating in Alzheimers research

PubMed Central

Karlawish, Jason; Rubright, Jonathan; Casarett, David; Cary, Mark; TenHave, Thomas; Sankar, Pamela

2008-01-01

Objective Since research that enrolls noncompetent patients with Alzheimers disease and does not present potential benefit to subjects is the source of substantial ethical controversy, we assessed willingness to have a proxy for research decision making, and, for each of two Alzheimers disease biomarker studies (minimal risk blood draw and a greater than minimal risk blood draw and lumbar puncture), willingness to grant an advance consent, and willingness to grant a proxy leeway over advance consent. Methods Face to face survey of 538 persons 65 and over who resided in the Southeastern Pennsylvania region Results The majority 83% (445/538) granted advance consent to a blood draw study and nearly half to a blood draw plus lumbar puncture 259 (48%). Most persons (96%) were willing to identify a proxy for research decision making and most were willing to grant their proxy leeway over their advance consent: blood draw 434 (81%), and 375 (70%) blood draw plus lumbar puncture. Combining the preferences for advance consent and leeway, the proportion who would permit being enrolled in the blood draw and spinal fluid sample studies were, respectively, 92% (497/538) and 75% (404/538). Multi-variate models showed that willingness to be enrolled in research was most strongly associated with a favorable attitude about biomedical research. Conclusions Older adults generally support enrolling noncompetent persons with Alzheimers disease into research that does not present a benefit to subjects. Willingness to grant their proxy leeway over advance consent and a favorable attitude about biomedical research substantially explain this willingness. PMID:18923066

Needs of people with advanced dementia in their final phase of life: A multi-perspective qualitative study in nursing homes.

PubMed

Schmidt, Holger; Eisenmann, Yvonne; Golla, Heidrun; Voltz, Raymond; Perrar, Klaus Maria

2018-03-01

People with advanced dementia present an important target group for palliative care. They suffer a range of symptoms, and their verbal communication abilities are highly restricted. At present, little is known about their needs in the final phase of life. To identify the needs of people with advanced dementia in their final phase of life and to explore the aspects relevant to first recognize and then meet these needs. Multi-perspective qualitative study using grounded theory methodology conducting group discussions, individual interviews, and participant observation. The study encompassed nursing homes and involved health professionals, relatives, and residents with advanced dementia. Data were collected in six nursing homes. Nine group discussions and three individual interviews were conducted comprising 42 health professionals and 14 relatives. Participant observations aided in giving the perspective of 30 residents with advanced dementia. Data analysis generated a total of 25 physical, psychosocial, and spiritual needs divided into 10 categories. Physical needs were classified as follows: "food intake," "physical well-being," and "physical activity and recovery." Categories of psychosocial needs were classified as follows: "adaptation of stimuli," "communication," "personal attention," "participation," "familiarity and safety," as well as "self-determination." Spiritual needs addressed "religion." The results revealed a multitude of key aspects for recognizing and meeting these needs, stressing the importance of personhood. People with advanced dementia in their final phase of life have a multitude of individual and complex needs. This evidence contributes to narrowing the current research gap, offering an orientation framework for research and practice.

High Fat Diet Induces Adhesion of Platelets to Endothelium in Two Models of Dyslipidemia

PubMed Central

Gonzalez, Jaime; Donoso, Wendy; Díaz, Natalia; Albornoz, María Eliana; Huilcaman, Ricardo; Morales, Erik

2014-01-01

Cardiovascular diseases (CVD) represent about 30% of all global deaths. It is currently accepted that, in the atherogenic process, platelets play an important role, contributing to endothelial activation and modulation of the inflammatory phenomenon, promoting the beginning and formation of lesions and their subsequent thrombotic complications. The objective of the present work was to study using immunohistochemistry, the presence of platelets, monocytes/macrophages, and cell adhesion molecules (CD61, CD163, and CD54), in two stages of the atheromatous process. CF-1 mice fed a fat diet were used to obtain early stages of atheromatous process, denominated early stage of atherosclerosis, and ApoE−/− mice fed a fat diet were used to observe advanced stages of atherosclerosis. The CF-1 mice model presented immunostaining on endothelial surface for all three markers studied; the advanced atherosclerosis model in ApoE−/− mice also presented granular immunostaining on lesion thickness, for the same markers. These results suggest that platelets participate in atheromatous process from early stages to advance d stages. High fat diet induces adhesion of platelets to endothelial cells in vivo. These findings support studying the participation of platelets in the formation of atheromatous plate. PMID:25328689

High fat diet induces adhesion of platelets to endothelium in two models of dyslipidemia.

PubMed

Gonzalez, Jaime; Donoso, Wendy; Díaz, Natalia; Albornoz, María Eliana; Huilcaman, Ricardo; Morales, Erik; Moore-Carrasco, Rodrigo

2014-01-01

Cardiovascular diseases (CVD) represent about 30% of all global deaths. It is currently accepted that, in the atherogenic process, platelets play an important role, contributing to endothelial activation and modulation of the inflammatory phenomenon, promoting the beginning and formation of lesions and their subsequent thrombotic complications. The objective of the present work was to study using immunohistochemistry, the presence of platelets, monocytes/macrophages, and cell adhesion molecules (CD61, CD163, and CD54), in two stages of the atheromatous process. CF-1 mice fed a fat diet were used to obtain early stages of atheromatous process, denominated early stage of atherosclerosis, and ApoE(-/-) mice fed a fat diet were used to observe advanced stages of atherosclerosis. The CF-1 mice model presented immunostaining on endothelial surface for all three markers studied; the advanced atherosclerosis model in ApoE(-/-) mice also presented granular immunostaining on lesion thickness, for the same markers. These results suggest that platelets participate in atheromatous process from early stages to advance d stages. High fat diet induces adhesion of platelets to endothelial cells in vivo. These findings support studying the participation of platelets in the formation of atheromatous plate.

Advanced propulsion for LEO-Moon transport. 1: A method for evaluating advanced propulsion performance

NASA Technical Reports Server (NTRS)

Stern, Martin O.

1992-01-01

This report describes a study to evaluate the benefits of advanced propulsion technologies for transporting materials between low Earth orbit and the Moon. A relatively conventional reference transportation system, and several other systems, each of which includes one advanced technology component, are compared in terms of how well they perform a chosen mission objective. The evaluation method is based on a pairwise life-cycle cost comparison of each of the advanced systems with the reference system. Somewhat novel and economically important features of the procedure are the inclusion not only of mass payback ratios based on Earth launch costs, but also of repair and capital acquisition costs, and of adjustments in the latter to reflect the technological maturity of the advanced technologies. The required input information is developed by panels of experts. The overall scope and approach of the study are presented in the introduction. The bulk of the paper describes the evaluation method; the reference system and an advanced transportation system, including a spinning tether in an eccentric Earth orbit, are used to illustrate it.

Frequency Dependence of Single-event Upset in Advanced Commerical PowerPC Microprocessors

NASA Technical Reports Server (NTRS)

Irom, Frokh; Farmanesh, Farhad F.; Swift, Gary M.; Johnston, Allen H.

2004-01-01

This paper examines single-event upsets in advanced commercial SOI microprocessors in a dynamic mode, studying SEU sensitivity of General Purpose Registers (GPRs) with clock frequency. Results are presented for SOI processors with feature sizes of 0.18 microns and two different core voltages. Single-event upset from heavy ions is measured for advanced commercial microprocessors in a dynamic mode with clock frequency up to 1GHz. Frequency and core voltage dependence of single-event upsets in registers is discussed.

Clinical presentation of retinoblastoma in Alexandria: A step toward earlier diagnosis.

PubMed

Soliman, Sameh E; Eldomiaty, Wesam; Goweida, Mohamed B; Dowidar, Amgad

2017-01-01

To evaluate the clinical presentation of retinoblastoma in Alexandria, Egypt, correlate the timing of accurate diagnosis with the presence of advanced disease and identify causes of delayed presentation. Retrospective noncomparative single institution study reviews demographic and clinical data of all new children with retinoblastoma presenting to Alexandria Main University ocular oncology clinic (OOC) from January 2012 to June 2014. Diagnosis time was from initial parental complaint to retinoblastoma diagnosis and referral time was from retinoblastoma diagnosis to presentation to the Alexandria OCC. Delayed Diagnosis and referral were counted if >2 weeks. Advanced presentation is defined as clinical TNMH (8th edition) staging of cT2 or cT3 (international intraocular retinoblastoma classification group D or E) in at least one eye or the presence of extra-ocular disease (cT4). Seventy eyes of 47 children were eligible: 52% unilateral, 7% with family history and 96% presented with leukocorea. Sixty-four percent of children had advanced intraocular disease and none had extra-ocular disease. Delayed presentation occurred in 58% of children and was significantly associated with advanced disease in both unilaterally and bilaterally affected children (p = 0.003, 0.002 respectively). The delay in diagnosis was more in unilateral cases while the delay in referral was more in bilateral cases. The main cause of delayed presentation in unilateral retinoblastoma was misdiagnosis (30%) while parental shopping for second medical opinion (30%) was the main cause in bilateral children. Delayed diagnosis is a problem affecting retinoblastoma management. Better medical education and training, health education and earlier screening are recommended to achieve earlier diagnosis.

National Trends and Predictors of Locally Advanced Penile Cancer in the United States (1998-2012).

PubMed

Chipollini, Juan; Chaing, Sharon; Peyton, Charles C; Sharma, Pranav; Kidd, Laura C; Giuliano, Anna R; Johnstone, Peter A; Spiess, Philippe E

2017-08-12

We analyzed the trends in presentation of squamous cell carcinoma (SCC) of the penis and determined the socioeconomic predictors for locally advanced (cT3-cT4) disease in the United States. The National Cancer Database was queried for patients with clinically nonmetastatic penile SCC and staging available from 1998 to 2012. Temporal trends per tumor stage were evaluated, and a multivariable logistic regression model was used to identify predictors for advanced presentation during the study period. A total of 5767 patients with stage ≤ T1-T2 (n = 5423) and T3-T4 (n = 344) disease were identified. Increasing trends were noted in all stages of penile SCC with a greater proportion of advanced cases over time (P = .001). Significant predictors of advanced presentation were age > 55 years, the presence of comorbidities, and Medicaid or no insurance (P < .05 for all). More penile SCC is being detected in the United States. Our results have demonstrated older age, presence of comorbidities, and Medicaid or no insurance as potential barriers to early access of care in the male population. Understanding the current socioeconomic gaps could help guide targeted interventions in vulnerable populations. Copyright © 2017 Elsevier Inc. All rights reserved.

Advanced Risk Reduction Tool (ARRT) Special Case Study Report: Science and Engineering Technical Assessments (SETA) Program

NASA Technical Reports Server (NTRS)

Kirsch, Paul J.; Hayes, Jane; Zelinski, Lillian

2000-01-01

This special case study report presents the Science and Engineering Technical Assessments (SETA) team's findings for exploring the correlation between the underlying models of Advanced Risk Reduction Tool (ARRT) relative to how it identifies, estimates, and integrates Independent Verification & Validation (IV&V) activities. The special case study was conducted under the provisions of SETA Contract Task Order (CTO) 15 and the approved technical approach documented in the CTO-15 Modification #1 Task Project Plan.

Shock Tunnel Studies of Scramjet Phenomena 1994

NASA Technical Reports Server (NTRS)

Morgan, R. G.; Paull, A.; Stalker, R. J.

1997-01-01

Reports by the research staff and graduate students of the Mechanical Engineering Department at the University of Queensland are collected and presented. These reports cover various studies related to the advancement of scramjet technology and the operation of advanced hypervelocity shock-expansion tubes. The report topics include the experimental studies of mixing and combustion in a scramjet flow path, the measurement of integrated thrust and skin friction, and the development of a free-piston-driven expansion tunnel capable of delivering a test gas at superorbital velocities.

Shock Tunnel Studies of Scramjet Phenomena 1995. Supplement 13

NASA Technical Reports Server (NTRS)

Morgan, R. G.; Stalker, R. J.; Paull, A.

1997-01-01

Reports by the research staff and graduate students of the Mechanical Engineering Department at the University of Queensland are collected and presented. These reports cover various studies related to the advancement of scramjet technology and the operation of advanced hypervelocity shock-expansion tubes. The report topics include the experimental studies of mixing and combustion in a scramjet flow path, the measurement of integrated thrust and skin friction, and the development of a free-piston-driven expansion tunnel capable delivering a test gas at super orbital velocities.

Proceedings of the Seventh Annual Summer Conference. NASA/USRA: University Advanced Design Program

NASA Technical Reports Server (NTRS)

1991-01-01

The Advanced Design Program (ADP) is a unique program that brings together students and faculty from U.S. engineering schools with engineers from the NASA centers through integration of current and future NASA space and aeronautics projects into university engineering design curriculum. The Advanced Space Design Program study topics cover a broad range of projects that could be undertaken during a 20-30 year period beginning with the deployment of the Space Station Freedom. The Advanced Aeronautics Design Program study topics typically focus on nearer-term projects of interest to NASA, covering from small, slow-speed vehicles through large, supersonic passenger transports and on through hypersonic research vehicles. Student work accomplished during the 1990-91 academic year and reported at the 7th Annual Summer Conference is presented.

Interlingual Influence in Bilingual Speech: Cognate Status Effect in a Continuum of Bilingualism

ERIC Educational Resources Information Center

Amengual, Mark

2012-01-01

The present study investigates voice onset times (VOTs) to determine if cognates enhance the cross-language phonetic influences in the speech production of a range of Spanish-English bilinguals: Spanish heritage speakers, English heritage speakers, advanced L2 Spanish learners, and advanced L2 English learners. To answer this question, lexical…

Career Advancement for African American School District Leaders: A Qualitative Study on Aspirations, Barriers, and Trust

ERIC Educational Resources Information Center

Robicheau, Jerry; Krull, Melissa

2016-01-01

In this article, the authors describe the use of phenomenology and thematic analysis to interpret raw data from interviews about the lived experiences of urban and suburban school African American administrators aspiring to the superintendency or another advanced school administrative position. The authors present overarching themes that capture…

The Scientific Revolution: A Unit of Study for Grades 7-10.

ERIC Educational Resources Information Center

Frick, Carole Collier

This unit is one of a series that presents specific moments in history from which students focus on the meanings of landmark events. The purpose of this unit is for the student to explore the advances in scientific knowledge made in Europe in the mid-sixteenth to mid-seventeenth centuries. These advances, beginning with Copernicus, radically…

Ten-year response of competing vegetation after oak shelterwood treatments in West Virginia

Treesearch

Gary W. Miller; James N. Kochenderfer; Jeffrey D. Kochenderfer; Kurt W. Gottschalk

2014-01-01

Successful oak regeneration depends on the relative status of advanced oak reproduction and associated competing woody vegetation present when harvests or other stand-replacing disturbances occur. This study was installed to quantify the effect of microsite light availability and deer browsing on the development of advanced northern red oak (Quercus rubra...

Seeking a Measure of General Educational Advancement: The Bentee. Final Report.

ERIC Educational Resources Information Center

Page, Ellis B.; Breen, Thomas F., III

Education suffers from the lack of any common measure of overall educational advancement, related in some clear way to the objectives of society. The present study proposes such a measure in the "bentee" (standing for benefit T-score) and provides evidence about its utility and form. Creation of a general "bentee" permits the…

Women Being Coached to Advance Their Careers to Positions of Power and Influence: A Narrative Inquiry

ERIC Educational Resources Information Center

Theune, Doris P.

2010-01-01

This study presents the discipline of executive coaching as a form of contemporary adult education informed by transformative learning theory appropriate for the education, support, and empowerment of adult women seeking to identify, understand, and break through the obstacles and barriers to career advancement to achieve positions of power and…

Advanced space program studies. Overall executive summary

NASA Technical Reports Server (NTRS)

Wolfe, M. G.

1977-01-01

NASA and DoD requirements and planning data were used in multidiscipline advanced planning investigations of space operations and associated elements (including man), identification of potential low cost approaches, vehicle design, cost synthesis techniques, technology forecasting and opportunities for DoD technology transfer, and the development near-, mid-, and far-term space initiatives and development plans with emphasis on domestic and military commonality. An overview of objectives and results are presented for the following studies: advanced space planning and conceptual analysis, shuttle users, technology assessment and new opportunities, standardization and program practice, integrated STS operations planning, solid spinning upper stage, and integrated planning support functions.

Advanced orbit transfer vehicle propulsion system study

NASA Technical Reports Server (NTRS)

Cathcart, J. A.; Cooper, T. W.; Corringrato, R. M.; Cronau, S. T.; Forgie, S. C.; Harder, M. J.; Mcallister, J. G.; Rudman, T. J.; Stoneback, V. W.

1985-01-01

A reuseable orbit transfer vehicle concept was defined and subsequent recommendations for the design criteria of an advanced LO2/LH2 engine were presented. The major characteristics of the vehicle preliminary design include a low lift to drag aerocapture capability, main propulsion system failure criteria of fail operational/fail safe, and either two main engines with an attitude control system for backup or three main engines to meet the failure criteria. A maintenance and servicing approach was also established for the advanced vehicle and engine concepts. Design tradeoff study conclusions were based on the consideration of reliability, performance, life cycle costs, and mission flexibility.

Interior noise control ground test studies for advanced turboprop aircraft applications

NASA Technical Reports Server (NTRS)

Simpson, Myles A.; Cannon, Mark R.; Burge, Paul L.; Boyd, Robert P.

1989-01-01

The measurement and analysis procedures are documented, and the results of interior noise control ground tests conducted on a DC-9 aircraft test section are summarized. The objectives of these tests were to study the fuselage response characteristics of treated and untreated aircraft with aft-mount advanced turboprop engines and to analyze the effectiveness of selected noise control treatments in reducing passenger cabin noise on these aircraft. The results of fuselage structural mode surveys, cabin cavity surveys and sound intensity surveys are presented. The performance of various structural and cabin sidewall treatments is assessed, based on measurements of the resulting interior noise levels under simulated advanced turboprop excitation.

Heritage Learners of Mexican Descent in Higher Education: A Qualitative Study of Past and Present Experiences

ERIC Educational Resources Information Center

Gignoux, Alicia

2009-01-01

This is a qualitative interpretive study that explores the past and present experiences of heritage learners (HLs) of Mexican descent who were studying or had recently studied advanced Spanish in institutions of higher education. All of the participants had been exposed to Spanish in the home and began their studies in elementary or middle school…

Chyle fistula in advanced and metastatic thyroid cancer

PubMed Central

Sánchez, Juan Guillermo; Dionigi, Gianlorenzo

2017-01-01

Background Chyle fistula (CF) is a rare but challenging condition for the surgeon and the patient’s health. Methods A retrospective review of single surgeon’s case load in a 12-year period is presented, reviewing the case of those patients presenting with a CF. Results Three patients were found during this study period from more than 1,050 surgeries performed due to thyroid cancer. Patients underwent extensive lymph node dissection for advanced, metastatic and infiltrative disease. In all patients, a long hospital stay and surgical re-interventions were required. Conclusions A description of the management of CF is presented along with a review of current Literature. PMID:29142832

Hyperspectral remote sensing of vegetation: knowledge gain and knowledge gap after 50 years of research (Conference Presentation)

NASA Astrophysics Data System (ADS)

Thenkabail, Prasad S.

2017-04-01

This presentation summarizes the advances made over 40+ years in understanding, modeling, and mapping terrestrial vegetation as reported in the new book on "Hyperspectral Remote Sensing of Vegetation" (Publisher:Taylor and Francis inc.). The advent of spaceborne hyperspectral sensors or imaging spectroscopy (e.g., NASA's Hyperion, ESA's PROBA, and upcoming Italy's ASI's Prisma, Germany's DLR's EnMAP, Japanese HIUSI, NASA's HyspIRI) as well as the advances made in processing when handling large volumes of hyperspectral data have generated tremendous interest in advancing the hyperspectral applications' knowledge base to large areas. Advances made in using hyperspectral data, relative to broadband data, include: (a) significantly improved characterization and modeling of a wide array of biophysical and biochemical properties of vegetation, (b) ability to discriminate plant species and vegetation types with high degree of accuracy, (c) reducing uncertainties in determining net primary productivity or carbon assessments from terrestrial vegetation, (d) improved crop productivity and water productivity models, (e) ability to assess stress resulting from causes such as management practices, pests and disease, water deficit or water excess, and (f) establishing more sensitive wavebands and indices to study vegetation characteristics. The presentation will discuss topics such as: (1) hyperspectral sensors and their characteristics, (2) methods of overcoming the Hughes phenomenon, (3) characterizing biophysical and biochemical properties, (4) advances made in using hyperspectral data in modeling evapotranspiration or actual water use by plants, (5) study of phenology, light use efficiency, and gross primary productivity, (5) improved accuracies in species identification and land cover classifications, and (6) applications in precision farming.

Advances in Scientific Balloon Thermal Modeling

NASA Technical Reports Server (NTRS)

Bohaboj, T.; Cathey, H. M., Jr.

2004-01-01

The National Aeronautics and Space Administration's Balloon Program office has long acknowledged that the accurate modeling of balloon performance and flight prediction is dependant on how well the balloon is thermally modeled. This ongoing effort is focused on developing accurate balloon thermal models that can be used to quickly predict balloon temperatures and balloon performance. The ability to model parametric changes is also a driver for this effort. This paper will present the most recent advances made in this area. This research effort continues to utilize the "Thrmal Desktop" addition to AUTO CAD for the modeling. Recent advances have been made by using this analytical tool. A number of analyses have been completed to test the applicability of this tool to the problem with very positive results. Progressively detailed models have been developed to explore the capabilities of the tool as well as to provide guidance in model formulation. A number of parametric studies have been completed. These studies have varied the shape of the structure, material properties, environmental inputs, and model geometry. These studies have concentrated on spherical "proxy models" for the initial development stages and then to transition to the natural shaped zero pressure and super pressure balloons. An assessment of required model resolution has also been determined. Model solutions have been cross checked with known solutions via hand calculations. The comparison of these cases will also be presented. One goal is to develop analysis guidelines and an approach for modeling balloons for both simple first order estimates and detailed full models. This papa presents the step by step advances made as part of this effort, capabilities, limitations, and the lessons learned. Also presented are the plans for further thermal modeling work.

Proceedings of the Fifteenth NASA Propagation Experimenters Meeting (NAPEX 15) and the Advanced Communications Technology Satellite (ACTS) Propagation Studies Miniworkshop

NASA Technical Reports Server (NTRS)

Davarian, Faramaz (Editor)

1991-01-01

The NASA Propagation Experimenters Meeting (NAPEX), supported by the NASA Propagation Program, is convened annually to discuss studies made on radio wave propagation by investigators from domestic and international organizations. The meeting was organized into three technical sessions. The first session was dedicated to Olympus and ACTS studies and experiments, the second session was focused on the propagation studies and measurements, and the third session covered computer-based propagation model development. In total, sixteen technical papers and some informal contributions were presented. Following NAPEX 15, the Advanced Communications Technology Satellite (ACTS) miniworkshop was held on 29 Jun. 1991, to review ACTS propagation activities, with emphasis on ACTS hardware development and experiment planning. Five papers were presented.

Advancing research and practice: the revised APA Division 30 definition of hypnosis.

PubMed

Elkins, Gary R; Barabasz, Arreed F; Council, James R; Spiegel, David

2015-01-01

This article describes the history, rationale, and guidelines for developing a new definition of hypnosis by the Society of Psychological Hypnosis, Division 30 of the American Psychological Association. The definition was developed with the aim of being concise, heuristic, and allowing for alternative theories of the mechanisms (to be determined in empirical scientific study). The definition of hypnosis is presented as well as definitions of the following related terms: hypnotic induction, hypnotizability, and hypnotherapy. The implications for advancing research and practice are discussed. The definitions are presented within the article.

Advancing Research and Practice: The Revised APA Division 30 Definition of Hypnosis.

PubMed

Elkins, Gary R; Barabasz, Arreed F; Council, James R; Spiegel, David

2015-04-01

This article describes the history, rationale, and guidelines for developing a new definition of hypnosis by the Society of Psychological Hypnosis, Division 30 of the American Psychological Association. The definition was developed with the aim of being concise, being heuristic, and allowing for alternative theories of the mechanisms (to be determined in empirical scientific study). The definition of hypnosis is presented as well as definitions of the following related terms: hypnotic induction, hypnotizability, and hypnotherapy. The implications for advancing research and practice are discussed. The definitions are presented within the article.

HARP model rotor test at the DNW. [Hughes Advanced Rotor Program

NASA Technical Reports Server (NTRS)

Dawson, Seth; Jordan, David; Smith, Charles; Ekins, James; Silverthorn, Lou

1989-01-01

Data from a test of a dynamically scaled model of the Hughes Advanced Rotor Program (HARP) bearingless model main rotor and 369K tail rotor are reported. The history of the HARP program and its goals are reviewed, and the main and tail rotor models are described. The test facilities and instrumentation are described, and wind tunnel test data are presented on hover, forward flight performance, and blade-vortex interaction. Performance data, acoustic data, and dynamic data from near field/far field and shear layer studies are presented.

Research and Applications in Aeroelasticity and Structural Dynamics at the NASA Langley Research Center

NASA Technical Reports Server (NTRS)

Abel, Irving

1997-01-01

An overview of recently completed programs in aeroelasticity and structural dynamics research at the NASA Langley Research Center is presented. Methods used to perform flutter clearance studies in the wind-tunnel on a high performance fighter are discussed. Recent advances in the use of smart structures and controls to solve aeroelastic problems, including flutter and gust response are presented. An aeroelastic models program designed to support an advanced high speed civil transport is described. An extension to transonic small disturbance theory that better predicts flows involving separation and reattachment is presented. The results of a research study to determine the effects of flexibility on the taxi and takeoff characteristics of a high speed civil transport are presented. The use of photogrammetric methods aboard Space Shuttle to measure spacecraft dynamic response is discussed. Issues associated with the jitter response of multi-payload spacecraft are discussed. Finally a Space Shuttle flight experiment that studied the control of flexible spacecraft is described.

Fractography of modern engineering materials: Composites and metals, Second volume

DOE Office of Scientific and Technical Information (OSTI.GOV)

Masters, J.E.; Gilbertson, L.N.

1993-01-01

This book contains the manuscripts of eleven papers that were presented at the Second Symposium on Fractography of Modern Engineering Materials held in May 1992. The numerous advances in materials science in the six year period following the First Symposium dictated this second meeting. Not only had new materials been developed in the intervening years, but understanding of older materials had also progressed. Similarly, advances in the technology and the techniques of fractography had occurred. The objective of the symposium was to extend the colloquy on fractography to include these many advances. The paper may be divided into three sections:more » Unique Fractographic Techniques; Metallic Materials; Polymeric and Composite Materials. The section titles reflect the diversity of materials discussed in the meeting. The range of materials included cross-linked polyethylene, AISI 52100 steel, 2024 aluminum, and a variety of organic and metal matrix fibrous composites. The case studies presented also covered a wide range. They included failure investigations of an antenna used in deep space exploration and chemical storage tanks. Advances in the techniques of fractography were also reflected in a number of presentations; quantitative techniques and expert systems were also subjects of presentations. A short precis of each paper is included here to assist the readers in identifying works of particular interest.« less

Primary healthcare NZ nurses' experiences of advance directives: understanding their potential role.

PubMed

Davidson, Raewyn; Banister, Elizabeth; de Vries, Kay

2013-07-01

Advance directives are one aspect of advance care planning designed to improve end of life care. The New Zealand Nurses Organisation released their first mission statement in 2010 concerning advance directives suggesting an increase in the use of these. A burgeoning older population, expected to rise over the next few years, places the primary healthcare nurse in a pivotal role to address the challenges in constructing advance directives. While literature supports the role for primary healthcare nurses in promoting advance directives, no research was found on this role in the New Zealand context. This paper presents results of a qualitative study conducted in New Zealand with 13 senior primary healthcare nurses with respect to their knowledge, attitudes, and experiences of advance directives. Results of the analysis revealed a dynamic process involving participants coming to understand their potential role in this area. This process included reflection on personal experience with advance directives; values and ethics related to end of life issues; and professional actions.

Contribution of developing advanced engineering methods in interdisciplinary studying the piston rings from 1.6 spark ignited Ford engine at Technical University of Cluj-Napoca

NASA Astrophysics Data System (ADS)

-Aurel Cherecheş, Ioan; -Ioana Borzan, Adela; -Laurean Băldean, Doru

2017-10-01

Study of construction and wearing process in the case of piston-rings and other significant components from internal combustion engines leads at any time to creative and useful optimizing ideas, both in designing and manufacturing phases. Main objective of the present paper is to realize an interdisciplinary research using advanced methods in piston-rings evaluation of a common vehicle on the streets which is Ford Focus FYDD. Specific objectives are a theoretical study of the idea for advanced analysis method in piston-rings evaluation and an applied research developed in at Technical University from Cluj-Napoca with the motor vehicle caught in the repairing process.

Systems study for an Integrated Digital-Electric Aircraft (IDEA)

NASA Technical Reports Server (NTRS)

Tagge, G. E.; Irish, L. A.; Bailey, A. R.

1985-01-01

The results of the Integrated Digital/Electric Aircraft (IDEA) Study are presented. Airplanes with advanced systems were, defined and evaluated, as a means of identifying potential high payoff research tasks. A baseline airplane was defined for comparison, typical of a 1990's airplane with advanced active controls, propulsion, aerodynamics, and structures technology. Trade studies led to definition of an IDEA airplane, with extensive digital systems and electric secondary power distribution. This airplane showed an improvement of 3% in fuel use and 1.8% in DOC relative to the baseline configuration. An alternate configuration, an advanced technology turboprop, was also evaluated, with greater improvement supported by digital electric systems. Recommended research programs were defined for high risk, high payoff areas appropriate for implementation under NASA leadership.

Behavioral science and the study of gene-nutrition and gene-physical activity interactions in obesity research.

PubMed

Faith, Myles S

2008-12-01

This report summarizes emerging opportunities for behavioral science to help advance the field of gene-environment and gene-behavior interactions, based on presentations at The National Cancer Institute (NCI) Workshop, "Gene-Nutrition and Gene-Physical Activity Interactions in the Etiology of Obesity." Three opportunities are highlighted: (i) designing potent behavioral "challenges" in experiments, (ii) determining viable behavioral phenotypes for genetics studies, and (iii) identifying specific measures of the environment or environmental exposures. Additional points are underscored, including the need to incorporate novel findings from neuroimaging studies regarding motivation and drive for eating and physical activity. Advances in behavioral science theory and methods can play an important role in advancing understanding of gene-brain-behavior relationships in obesity onset.

Considering Intermittent Dormancy in an Advanced Life Support Systems Architecture

NASA Technical Reports Server (NTRS)

Sargusingh, Miriam J.; Perry, Jay L.

2017-01-01

Many advanced human space exploration missions being considered by the National Aeronautics and Space Administration (NASA) include concepts in which in-space systems cycle between inhabited and uninhabited states. Managing the life support system (LSS) may be particularly challenged during these periods of intermittent dormancy. A study to identify LSS management challenges and considerations relating to dormancy is described. The study seeks to define concepts suitable for addressing intermittent dormancy states and to evaluate whether the reference LSS architectures being considered by the Advanced Exploration Systems (AES) Life Support Systems Project (LSSP) are sufficient to support this operational state. The primary focus of the study is the mission concept considered to be the most challenging-a crewed Mars mission with an extensive surface stay. Results from this study are presented and discussed.

No Value for Routine Chest Radiography in the Work-Up of Early Stage Cervical Cancer Patients

PubMed Central

Hoogendam, Jacob P.; Zweemer, Ronald P.; Verkooijen, Helena M.; de Jong, Pim A.; van den Bosch, Maurice A. A. J.; Verheijen, René H. M.; Veldhuis, Wouter B.

2015-01-01

Aim Evidence supporting the recommendation to include chest radiography in the work-up of all cervical cancer patients is limited. We investigated the diagnostic value of routine chest radiography in cervical cancer staging. Methods All consecutive cervical cancer patients who presented at our tertiary referral center in the Netherlands (January 2006 – September 2013), and for whom ≥6 months follow-up was available, were included. As part of the staging procedure, patients underwent a routine two-directional digital chest radiograph. Findings were compared to a composite reference standard consisting of all imaging studies and histology obtained during the 6 months following radiography. Results Of the 402 women who presented with cervical cancer, 288 (71.6%) underwent chest radiography and had ≥6 months follow-up. Early clinical stage (I/II) cervical cancer was present in 244/288 (84.7%) women, while 44 (15.3%) presented with advanced disease (stage III/IV). The chest radiograph of 1 woman – with advanced pre-radiograph stage (IVA) disease – showed findings consistent with pulmonary metastases. Radiographs of 7 other women – 4 early, 3 advanced stage disease – were suspicious for pulmonary metastases which was confirmed by additional imaging in only 1 woman (with pre-radiograph advanced stage (IIIB) disease) and excluded in 6 cases, including all women with early stage disease. In none of the 288 women were thoracic skeletal metastases identified on imaging or during 6 months follow up. Radiography was unremarkable in 76.4% of the study population, and showed findings unrelated to the cervical carcinoma in 21.2%. Conclusion Routine chest radiography was of no value for any of the early stage cervical cancer patients presenting at our tertiary center over a period of 7.7 years. PMID:26135733

No Value for Routine Chest Radiography in the Work-Up of Early Stage Cervical Cancer Patients.

PubMed

Hoogendam, Jacob P; Zweemer, Ronald P; Verkooijen, Helena M; de Jong, Pim A; van den Bosch, Maurice A A J; Verheijen, René H M; Veldhuis, Wouter B

2015-01-01

Evidence supporting the recommendation to include chest radiography in the work-up of all cervical cancer patients is limited. We investigated the diagnostic value of routine chest radiography in cervical cancer staging. All consecutive cervical cancer patients who presented at our tertiary referral center in the Netherlands (January 2006 - September 2013), and for whom ≥6 months follow-up was available, were included. As part of the staging procedure, patients underwent a routine two-directional digital chest radiograph. Findings were compared to a composite reference standard consisting of all imaging studies and histology obtained during the 6 months following radiography. Of the 402 women who presented with cervical cancer, 288 (71.6%) underwent chest radiography and had ≥6 months follow-up. Early clinical stage (I/II) cervical cancer was present in 244/288 (84.7%) women, while 44 (15.3%) presented with advanced disease (stage III/IV). The chest radiograph of 1 woman - with advanced pre-radiograph stage (IVA) disease - showed findings consistent with pulmonary metastases. Radiographs of 7 other women - 4 early, 3 advanced stage disease - were suspicious for pulmonary metastases which was confirmed by additional imaging in only 1 woman (with pre-radiograph advanced stage (IIIB) disease) and excluded in 6 cases, including all women with early stage disease. In none of the 288 women were thoracic skeletal metastases identified on imaging or during 6 months follow up. Radiography was unremarkable in 76.4% of the study population, and showed findings unrelated to the cervical carcinoma in 21.2%. Routine chest radiography was of no value for any of the early stage cervical cancer patients presenting at our tertiary center over a period of 7.7 years.

Clinical presentation of intraocular retinoblastoma; 5-year hospital-based registry in Egypt.

PubMed

El Zomor, Hossam; Nour, Radwa; Alieldin, Adel; Taha, Hala; Montasr, Mohamed M; Moussa, Emad; El Nadi, Enas; Ezzat, Sameera; Alfaar, Ahmad S

2015-12-01

To study the presenting signs of Retinoblastoma in Egypt at Egypt's main pediatric oncology referral center. This is a prospective descriptive study (hospital-based registry) conducted at Children's Cancer Hospital Egypt between July 2007 and December 2012. Out of 262 patients diagnosed with retinoblastoma, 244 were suffering from intra-ocular disease at presentation. One hundred thirty-nine (57%) patients presented with unilateral disease, while 105 (43%) suffered bilateral disease. The mean age at presentation was 20.6 ± 17 months, averaging 18.87 ± 11.76 months for bilateral and 25.72 ± 18.78 months for unilateral disease. The most common clinical presentation was leukocoria in 180 (73.8%) patients, strabismus in 32 (13.1%) patients and decreased visual acuity in 12 (4.9%) patients. Group D and E disease represented 62% of all affected eyes. Patients with advanced disease (Group C-E) had longer duration of symptoms. In Egypt, retinoblastoma patients present more frequently with advanced disease. There is an ever-increasing need to develop a national team dedicated to studying disease significance and formulating a national awareness program. Copyright © 2015 The Authors. Production and hosting by Elsevier B.V. All rights reserved.

Research Studies on Advanced Optical Module/Head Designs for Optical Disk Recording Devices

NASA Technical Reports Server (NTRS)

Burke, James J.; Seery, Bernard D.

1993-01-01

The Annual Report of the Optical Data Storage Center of the University of Arizona is presented. Summary reports on continuing projects are presented. Research areas include: magneto-optic media, optical heads, and signal processing.

Advancing Critical Vocational Education Research.

ERIC Educational Resources Information Center

Lakes, Richard D.; Bettis, Pamela J.

1995-01-01

Presents postpositivism as a useful method for understanding the cultural context of work. Highlights the critical theory approach, presenting qualitative studies that use this framework. Recommends critical research as a way to achieve the democratic transformation of schools and workplaces. (SK)

Advanced Platform Systems Technology study. Volume 4: Technology advancement program plan

NASA Technical Reports Server (NTRS)

1983-01-01

An overview study of the major technology definition tasks and subtasks along with their interfaces and interrelationships is presented. Although not specifically indicated in the diagram, iterations were required at many steps to finalize the results. The development of the integrated technology advancement plan was initiated by using the results of the previous two tasks, i.e., the trade studies and the preliminary cost and schedule estimates for the selected technologies. Descriptions for the development of each viable technology advancement was drawn from the trade studies. Additionally, a logic flow diagram depicting the steps in developing each technology element was developed along with descriptions for each of the major elements. Next, major elements of the logic flow diagrams were time phased, and that allowed the definition of a technology development schedule that was consistent with the space station program schedule when possible. Schedules show the major milestone including tests required as described in the logic flow diagrams.

Treating advanced non-small-cell lung cancer in Chinese patients: focus on icotinib

PubMed Central

Liang, Jun-Li; Ren, Xiao-Cang; Lin, Qiang

2014-01-01

Icotinib hydrochloride is an orally administered small-molecule reversible tyrosine kinase inhibitor that has been independently researched and developed and has independent intellectual property rights in the People’s Republic of China. Clinical trials have demonstrated that the response to icotinib among advanced non-small-cell lung cancer (NSCLC) patients who received at least one platinum-based chemotherapy regimen was not inferior to gefitinib. Since being launched August 2011 in the People’s Republic of China, icotinib has been widely used in clinics, and has become an important treatment option for Chinese patients with advanced NSCLC. The present study presents the Phase I, II, and III clinical trials of icotinib and discusses current clinical applications in the People’s Republic of China and future research directions. PMID:24876785

Space Electrochemical Research and Technology (SERT), 1989

NASA Technical Reports Server (NTRS)

Baldwin, Richard S. (Editor)

1989-01-01

The proceedings of NASA's second Space Electrochemical Research and Technology Conference are presented. The objectives of the conference were to examine current technologies, research efforts, and advanced ideas, and to identify technical barriers which affect the advancement of electrochemical energy storage systems for space applications. The conference provided a forum for the exchange of ideas and opinions of those actively involved in the field, with the intention of coalescing views and findings into conclusions on progress in the field, prospects for future advances, areas overlooked, and the directions of future efforts. Related overviews were presented in the areas of NASA advanced mission models. Papers were presented and workshops conducted in four technical areas: advanced concepts, hydrogen-oxygen fuel cells and electrolyzers, the nickel electrode, and advanced rechargable batteries.

Facebook and Classroom Group Work: A Trial Study Involving University of Botswana Advanced Oral Presentation Students

ERIC Educational Resources Information Center

Magogwe, Joel M.; Ntereke, Beauty; Phetlhe, Keith R.

2015-01-01

In the 21st century, the use of information technology in the classroom is advancing rapidly, especially in higher education. The Internet, through social networking, has made it possible for students to learn and teachers to teach outside the classroom walls. Facebook in particular has made it possible for students to interact and communicate…

Advanced Undergraduate and Early Graduate Physics Students' Misconception about Solar Wind Flow: Evidence of Students' Difficulties in Distinguishing Paradigms

ERIC Educational Resources Information Center

Gross, Nicholas A.; Lopez, Ramon E.

2009-01-01

Anecdotal evidence has suggested that advanced undergraduate students confuse the spiral structure of the interplanetary magnetic field with the flow of the solar wind. Though it is a small study, this paper documents this misconception and begins to investigate the underlying issues behind it. We present evidence that the traditional presentation…

Implementing the Constructed Scaffold Model: Hands-On Activity Units for Advanced Placement Calculus

ERIC Educational Resources Information Center

Scott, Susan

2017-01-01

The purpose of the present action research study is to describe a hands-on activity model, named the Constructed Scaffold Model (CSM), used in an Advanced Placement Calculus class in a southeastern United States suburban high school. Data were collected over an 8-week period during the spring 2017 semester. The teacher-researcher developed a…

Determining Advanced and Basic Financial Literacy Relations and Overconfidence, and Informative Social Media Association of University Students in Turkey

ERIC Educational Resources Information Center

Karaa, Ibrahim E.; Kugu, Tayfun D.

2016-01-01

The purposes of the paper are, first, to investigate financial literacy in university students and to determine the relationship between basic and advanced financial literacy; second, to present a positive association between social media usage and financial literacy; third, to examine demographic factors consistent with previous studies; and,…

Effect of Pre-Harvest Shade Control and Fencing on Northern Red oak Seedling Development in the Central Appalachians

Treesearch

Gary W. Miller; James N. Kochenerfer; Kurt W. Gottschalk

2004-01-01

Successful oak regeneration is related to the size and number of advanced seedlings present when harvests occur. This study was installed to quantify the effect of microsite light availability and deer on the development of advanced northern red oak (Quercus rubra L.) reproduction in mesic Appalachian hardwood stands. Microsite light was manipulated...

An Investigation of College Students' Perceptions of Advanced Placement® Courses. Research Note 2013-2

ERIC Educational Resources Information Center

Cooney, Siobhan M.; McKillip, Mary E. M.; Smith, Kara

2013-01-01

The present study investigates how current college students perceive their experiences in high school Advanced Placement Program (AP) courses. The goal of this research was twofold: We wanted to not only add to the existing literature on outcomes for AP students but also investigate possible benefits for students without success (i.e., a score of…

Communication in Medicine: A Study of How Family Doctors Obtain Information on Recent Advances in the Treatment of Rheumatic Diseases

ERIC Educational Resources Information Center

Murray-Lyon, N.

1977-01-01

The results of a questionnaire on how 131 family doctors in Glasgow and the West of Scotland obtain information regarding recent advances are described, indicating that medical journals and formal lectures and symposia are still popular. Tape/slide and television presentations were not considered of much value. (Author/LBH)

Corrosion science, corrosion engineering, and advanced technologies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Latanision, R.M.

1995-04-01

Professor R.M. Latanision was the 1994 recipient of the Willis Rodney Whitney Award sponsored by NACE International. The present work is taken from his award lecture at CORROSION/94 held in March 1994 in Baltimore, MD. Latanision discussed the interplay between corrosion science and corrosion engineering in advancing technology. His lecture focused on supercritical water oxidation and other technologies that have been under study in the H.H. Uhlig Corrosion Laboratory and in which the chemical properties of new materials and traditional materials have proven integral to the development of contemporary or advanced engineering systems.

Recent advances in plasma modeling for space applications

NASA Astrophysics Data System (ADS)

Srinivasan, Bhuvana; Scales, Wayne; Cagas, Petr; Glesner, Colin

2017-02-01

This paper presents a brief overview of the application of advanced plasma modeling techniques to several space science and engineering problems currently of significant interest. Recent advances in both kinetic and fluid modeling provide the ability to study a wide variety of problems that may be important to space plasmas including spacecraft-environment interactions, plasma-material interactions for propulsion systems such as Hall thrusters, ionospheric plasma instabilities, plasma separation from magnetic nozzles, active space experiments, and a host of additional problems. Some of the key findings are summarized here.

Cost of Medical Care of Patients with Advanced Serious Illness in Singapore (COMPASS): prospective cohort study protocol.

PubMed

Teo, Irene; Singh, Ratna; Malhotra, Chetna; Ozdemir, Semra; Dent, Rebecca A; Kumarakulasinghe, Nesaretnam Barr; Yeo, Wee Lee; Cheung, Yin Bun; Malhotra, Rahul; Kanesvaran, Ravindran; Yee, Alethea Chung Pheng; Chan, Noreen; Wu, Huei Yaw; Chin, Soh Mun; Allyn, Hum Yin Mei; Yang, Grace Meijuan; Neo, Patricia Soek Hui; Nadkarni, Nivedita V; Harding, Richard; Finkelstein, Eric A

2018-04-23

Advanced cancer significantly impacts quality of life of patients and families as they cope with symptom burden, treatment decision-making, uncertainty and costs of treatment. In Singapore, information about the experiences of advanced cancer patients and families and the financial cost they incur for end-of-life care is lacking. Understanding of this information is needed to inform practice and policy to ensure continuity and affordability of care at the end of life. The primary objectives of the Cost of Medical Care of Patients with Advanced Serious Illness in Singapore (COMPASS) cohort study are to describe changes in quality of life and to quantify healthcare utilization and costs of patients with advanced cancer at the end of life. Secondary objectives are to investigate patient and caregiver preferences for diagnostic and prognostic information, preferences for end-of-life care, caregiver burden and perceived quality of care and to explore how these change as illness progresses and finally to measure bereavement adjustment. The purpose of this paper is to present the COMPASS protocol in order to promote scientific transparency. This cohort study recruits advanced cancer patients (n = 600) from outpatient medical oncology clinics at two public tertiary healthcare institutions in Singapore. Patients and their primary informal caregiver are surveyed every 3 months until patients' death; caregivers are followed until 6 months post patient death. Patient medical and billing records are obtained and merged with patient survey data. The treating medical oncologists of participating patients are surveyed to obtain their beliefs regarding care delivery for the patient. The study will allow combination of self-report, medical, and cost data from various sources to present a comprehensive picture of the end-of-life experience of advanced cancer patients in a unique Asian setting. This study is responsive to Singapore's National Strategy for Palliative Care which aims to identify opportunities to meet the growing need for high quality care for Singapore's aging population. Results will also be of interest to policy makers and researchers beyond Singapore who are interested to understand and improve the end-of-life experience of cancer patients. NCT02850640 (Prospectively registered on June 9, 2016).

The relevance of Newton's laws and selected principles of physics to dance techniques: Theory and application

NASA Astrophysics Data System (ADS)

Lei, Li

1999-07-01

In this study the researcher develops and presents a new model, founded on the laws of physics, for analyzing dance technique. Based on a pilot study of four advanced dance techniques, she creates a new model for diagnosing, analyzing and describing basic, intermediate and advanced dance techniques. The name for this model is ``PED,'' which stands for Physics of Expressive Dance. The research design consists of five phases: (1) Conduct a pilot study to analyze several advanced dance techniques chosen from Chinese dance, modem dance, and ballet; (2) Based on learning obtained from the pilot study, create the PED Model for analyzing dance technique; (3) Apply this model to eight categories of dance technique; (4) Select two advanced dance techniques from each category and analyze these sample techniques to demonstrate how the model works; (5) Develop an evaluation framework and use it to evaluate the effectiveness of the model, taking into account both scientific and artistic aspects of dance training. In this study the researcher presents new solutions to three problems highly relevant to dance education: (1) Dancers attempting to learn difficult movements often fail because they are unaware of physics laws; (2) Even those who do master difficult movements can suffer injury due to incorrect training methods; (3) Even the best dancers can waste time learning by trial and error, without scientific instruction. In addition, the researcher discusses how the application of the PED model can benefit dancers, allowing them to avoid inefficient and ineffective movements and freeing them to focus on the artistic expression of dance performance. This study is unique, presenting the first comprehensive system for analyzing dance techniques in terms of physics laws. The results of this study are useful, allowing a new level of awareness about dance techniques that dance professionals can utilize for more effective and efficient teaching and learning. The approach utilized in this study is universal, and can be applied to any dance movement and to any dance style.

Treatment of advanced canine anal sac adenocarcinoma with hypofractionated radiation therapy: 77 cases (1999-2013).

PubMed

McQuown, B; Keyerleber, M A; Rosen, K; McEntee, M C; Burgess, K E

2017-09-01

Currently no standard of care exists for advanced, inoperable or metastatic anal sac adenocarcinoma (ASAC). The objective of this retrospective study was to assess the role of hypofractionated radiation therapy (RT) in 77 dogs with measurable ASAC. A total of 38% of dogs experienced a partial response to RT. For dogs presenting with clinical signs related to the tumour, improvement or resolution of signs was noted in 63%. For dogs presenting with hypercalcemia of malignancy, resolution was noted in 31% with RT alone and an additional 46% with radiation, prednisone, and/or bisphosphonates. Median overall survival was 329 days (range: 252-448 days). Median progression free survival was 289 days (range: 224-469). There was no difference in survival based on radiation protocol, use of chemotherapy, previous surgery or advanced stage. Radiation toxicities were mild and infrequent. Hypofractionated RT is well tolerated and is applicable in the treatment of advanced primary, locoregional or metastatic ASAC. © 2016 John Wiley & Sons Ltd.

Developing support for remote nursing education through workplace culture that values learning.

PubMed

Gibb, Heather; Anderson, Judith; Forsyth, Katreena

2004-10-01

The present study presents the cultural challenges of introducing workplace learning associated with a nursing educational pathway into small rural hospitals. Focus groups were conducted before and after an action research intervention to determine whether changes in understanding and values on learning had occurred. Eight multipurpose services or small rural hospitals across rural New South Wales were involved in the intervention. Nursing staff from eight rural health facilities participated voluntarily in the present study. Two outcomes were achieved: The development of mentoring, locally tailored to the needs and expectations of nursing participants; Values and understanding of learning were enhanced, with advanced levels of learning being identified and demonstrated by staff in the practice setting. Small rural hospitals can provide opportunities for advanced clinical learning. Forms of major mentoring are, however, critical to this process.

Classification Studies in an Advanced Air Classifier

NASA Astrophysics Data System (ADS)

Routray, Sunita; Bhima Rao, R.

2016-10-01

In the present paper, experiments are carried out using VSK separator which is an advanced air classifier to recover heavy minerals from beach sand. In classification experiments the cage wheel speed and the feed rate are set and the material is fed to the air cyclone and split into fine and coarse particles which are collected in separate bags. The size distribution of each fraction was measured by sieve analysis. A model is developed to predict the performance of the air classifier. The objective of the present model is to predict the grade efficiency curve for a given set of operating parameters such as cage wheel speed and feed rate. The overall experimental data with all variables studied in this investigation is fitted to several models. It is found that the present model is fitting good to the logistic model.

Computational studies of horizontal axis wind turbines in high wind speed condition using advanced turbulence models

NASA Astrophysics Data System (ADS)

Benjanirat, Sarun

Next generation horizontal-axis wind turbines (HAWTs) will operate at very high wind speeds. Existing engineering approaches for modeling the flow phenomena are based on blade element theory, and cannot adequately account for 3-D separated, unsteady flow effects. Therefore, researchers around the world are beginning to model these flows using first principles-based computational fluid dynamics (CFD) approaches. In this study, an existing first principles-based Navier-Stokes approach is being enhanced to model HAWTs at high wind speeds. The enhancements include improved grid topology, implicit time-marching algorithms, and advanced turbulence models. The advanced turbulence models include the Spalart-Allmaras one-equation model, k-epsilon, k-o and Shear Stress Transport (k-o-SST) models. These models are also integrated with detached eddy simulation (DES) models. Results are presented for a range of wind speeds, for a configuration termed National Renewable Energy Laboratory Phase VI rotor, tested at NASA Ames Research Center. Grid sensitivity studies are also presented. Additionally, effects of existing transition models on the predictions are assessed. Data presented include power/torque production, radial distribution of normal and tangential pressure forces, root bending moments, and surface pressure fields. Good agreement was obtained between the predictions and experiments for most of the conditions, particularly with the Spalart-Allmaras-DES model.

HIV impact on women: gender difference among late testers and advanced HIV infection

NASA Astrophysics Data System (ADS)

Sukmawati, N. M. D. D.; Merati, T. P.; Somia, A.; Utama, S.; Gayatri, Y.

2018-03-01

This study reported the effect of gender difference on HIV seropositive late testers or advanced infection. A retrospective cohort study of newly diagnosed HIV seropositive based on adatabase in the main referral hospital in Denpasar, Bali, Indonesia from 2004 – 2016. Women and man were categorized as late testers (CD4 ≤ 200 cells/uL and/or AIDS diagnosis ≤ 12 months from first HIV test date). Non-late testers (CD4 > 200 cells/uL and/or no AIDS diagnosis during study period or diagnosis of AIDS >12 months from HIV diagnosis), of reproductive age (13 – 49 years old), and not of reproductive age (>49 years old). Logistic regression was used to estimate risk and its statistical significance. The model consists of gender and age correctly classified 83.5% of cases. Women were almost two times more likely to present as non-late testers compared to men, and reproductive age of 15 – 49 years were 1.5 times more likely to present as non-late testers compared to those with age > 49 years. Women affected by HIV almost in equal as for men. Women and those within reproductive age were more likely to present before the advanced stage compared to men and those aged > 49 years.

Overview of Experimental Capabilities - Supersonics

NASA Technical Reports Server (NTRS)

Banks, Daniel W.

2007-01-01

This viewgraph presentation gives an overview of experimental capabilities applicable to the area of supersonic research. The contents include: 1) EC Objectives; 2) SUP.11: Elements; 3) NRA; 4) Advanced Flight Simulator Flexible Aircraft Simulation Studies; 5) Advanced Flight Simulator Flying Qualities Guideline Development for Flexible Supersonic Transport Aircraft; 6) Advanced Flight Simulator Rigid/Flex Flight Control; 7) Advanced Flight Simulator Rapid Sim Model Exchange; 8) Flight Test Capabilities Advanced In-Flight Infrared (IR) Thermography; 9) Flight Test Capabilities In-Flight Schlieren; 10) Flight Test Capabilities CLIP Flow Calibration; 11) Flight Test Capabilities PFTF Flowfield Survey; 12) Ground Test Capabilities Laser-Induced Thermal Acoustics (LITA); 13) Ground Test Capabilities Doppler Global Velocimetry (DGV); 14) Ground Test Capabilities Doppler Global Velocimetry (DGV); and 15) Ground Test Capabilities EDL Optical Measurement Capability (PIV) for Rigid/Flexible Decelerator Models.

Polymer infiltration studies

NASA Technical Reports Server (NTRS)

Marchello, Joseph M.

1992-01-01

Progress was made in several areas on the preparation of carbon fiber composites using advanced polymer resins. Polymer infiltration studies dealt with ways of preparing composite materials from advanced polymer resins and carbon fibers. This effort is comprised of an integrated approach to the process of composite part fabrication. The goal is to produce advanced composite materials for automated part fabrication using textile and robotics technology in the manufacture of subsonic and supersonic aircraft. The object is achieved through investigations at the NASA Langley Research Center and by stimulating technology transfer between contract researchers and the aircraft industry. Covered here are literature reviews, a status report on individual projects, current and planned research, publications, and scheduled technical presentations.

Activated alumina preparation and characterization: The review on recent advancement

NASA Astrophysics Data System (ADS)

Rabia, A. R.; Ibrahim, A. H.; Zulkepli, N. N.

2018-03-01

Aluminum and aluminum based material are significant industrial materials synthesis because of their abandonment, low weight and high-quality corrosion resistance. The most advances in aluminum processing are the ability to synthesize it's under suitable chemical composition and conditions, a porous structure can be formed on the surface. Activated alumina particles (AAP) synthesized by the electrochemically process from aluminum have gained serious attention, inexpensive material that can be employed for water filtration due to its active surface. Thus, the paper present a review study based on recent progress and advances in synthesizing activated alumina, various techniques currently being used in preparing activated alumina and its characteristics are studied and summarized

Emergency contraception: why can't you give it away? Qualitative findings from an evaluation of advance provision of emergency contraception.

PubMed

Fairhurst, Karen; Ziebland, Sue; Wyke, Sally; Seaman, Peter; Glasier, Anna

2004-07-01

The Lothian Emergency Contraception Project (LECP)--a primary care-based intervention to offer advance supplies of emergency contraception (EC) to women aged 16-29 was not associated with a reduction in abortion rates. We undertook case studies, utilizing qualitative and quantitative methods, to evaluate the intervention. In this article we present findings from qualitative interviews with 44 primary care professionals working at case study sites and 22 women who had received advance supplies to explain this failure. Professionals reported that women rarely asked for advance supplies of EC and they were reluctant to offer supplies to women because of concerns about contradictory sexual health messages implied by the offer, a perceived association of EC use with chaotic behavior by women, views about the sort of women suitable for advance supplies and practical difficulties making the offer. Women were reluctant to ask for advance supplies because of misgivings about the appropriateness of offering advance supplies to everybody and concerns about being judged by health professionals as morally inadequate. If advance provision of EC is to be successful in reducing abortion rates, professionals must address their concerns about EC and develop imaginative ways of encouraging women most at risk of unwanted pregnancy to take supplies home.

Hydrogen Research for Spaceport and Space-Based Applications: Hydrogen Production, Storage, and Transport. Part 3

NASA Technical Reports Server (NTRS)

Anderson, Tim; Balaban, Canan

2008-01-01

The activities presented are a broad based approach to advancing key hydrogen related technologies in areas such as fuel cells, hydrogen production, and distributed sensors for hydrogen-leak detection, laser instrumentation for hydrogen-leak detection, and cryogenic transport and storage. Presented are the results from research projects, education and outreach activities, system and trade studies. The work will aid in advancing the state-of-the-art for several critical technologies related to the implementation of a hydrogen infrastructure. Activities conducted are relevant to a number of propulsion and power systems for terrestrial, aeronautics and aerospace applications. Hydrogen storage and in-space hydrogen transport research focused on developing and verifying design concepts for efficient, safe, lightweight liquid hydrogen cryogenic storage systems. Research into hydrogen production had a specific goal of further advancing proton conducting membrane technology in the laboratory at a larger scale. System and process trade studies evaluated the proton conducting membrane technology, specifically, scale-up issues.

Advanced Propfan Engine Technology (APET) definition study, single and counter-rotation gearbox/pitch change mechanism design

NASA Technical Reports Server (NTRS)

Anderson, R. D.

1985-01-01

Single-rotation propfan-powered regional transport aircraft were studied to identify key technology development issues and programs. The need for improved thrust specific fuel consumption to reduce fuel burned and aircraft direct operating cost is the dominant factor. Typical cycle trends for minimizing fuel consumption are reviewed, and two 10,000 shp class engine configurations for propfan propulsion systems for the 1990's are presented. Recommended engine configurations are both three-spool design with dual spool compressors and free power turbines. The benefits of these new propulsion system concepts were evaluated using an advanced airframe, and results are compared for single-rotation propfan and turbofan advanced technology propulsion systems. The single-rotation gearbox is compared to a similar design with current technology to establish the benefits of the advanced gearbox technology. The conceptual design of the advanced pitch change mechanism identified a high pressure hydraulic system that is superior to the other contenders and completely external to the gearboxes.

VSCE technology definition study

NASA Technical Reports Server (NTRS)

Howlett, R. A.; Hunt, R. B.

1979-01-01

Refined design definition of the variable stream control engine (VSCE) concept for advanced supersonic transports is presented. Operating and performance features of the VSCE are discussed, including the engine components, thrust specific fuel consumption, weight, noise, and emission system. A preliminary engine design is presented.

An early glimpse at long-term subsonic commercial turbofan technology requirements. [fuel conservation

NASA Technical Reports Server (NTRS)

Gray, D. E.; Dugan, J. F.

1975-01-01

This paper reports on the exploratory investigation and initial findings of the study of future turbofan concepts to conserve fuel. To date, these studies have indicated a potential reduction in cruise thrust specific fuel consumption in 1990 turbofans of approximately 15% relative to present day new engines through advances in internal aerodynamics, structure-mechanics, and materials. Advanced materials also offer the potential for fuel savings through engine weight reduction. Further studies are required to balance fuel consumption reduction with sound airlines operational economics.

Predictors of Locally Advanced Disease at Presentation and Clinical Outcomes Among Cervical Cancer Patients Admitted at a Tertiary Hospital in Botswana.

PubMed

Nassali, Mercy Nkuba; Tadele, Melese; Nkuba, Robert Michael; Modimowame, Jamieson; Enyeribe, Iwuh; Katse, Edwin

2018-05-23

The aim of this study was to determine predictors of locally advanced disease at presentation and clinical outcomes among cervical cancer patients in Botswana to inform interventional strategies. Retrospective review of 149 medical records of new cervical cancer patients was conducted between August 2016 and February 2017 at the Princess Marina Hospital. Data collected included sociodemographics, presenting symptoms, stage of disease, comorbidities, interventions, and clinical outcomes. STATA 12 was used for data analysis. Frequencies were used to describe patient demographics and clinical variables. Bivariate and multivariate binary logistic regression analyses were used to determine association between stage of disease at presentation and patient characteristics. P ≤ 0.05 was considered significant. Mean age was 49.5 years. Nine (89.2%) in 10 patients had locally advanced cervical cancer (stage IB1-IVB). Two thirds (65.1%) were human immunodeficiency virus positive. Previous cervical cancer screening was low at 38.3%. Common symptoms were abnormal vaginal bleeding, low abdominal pain, and malodorous vaginal discharge reported among 75.8%, 66.4%, and 39.6% of cases, respectively. Overall, 32 (21.5%) were declared cured, 52 (34.9%) improved, and 11 (7.4%) opted for home-based care. Hospital deaths were 41 (27.5%). Major causes of death were renal failure (48.7%) and severe anemia (39%). Thirteen (8.7%) were lost to follow-up. Being unmarried (odds ratio [OR], 3.9), lack of cervical cancer screening (OR, 6.68), presentation with vaginal bleeding (OR, 7.69), and low abdominal pain (OR, 4.69) were associated with advanced disease at presentation. Lack of cervical cancer screening, vaginal bleeding, low abdominal pain, and unmarried status were associated with advanced disease at presentation. We recommend scale-up of cervical cancer screening and its integration into routine human immunodeficiency virus care. Capacity building in gynecologic oncology and palliative care services is currently critical.

Targeted genetic and viral therapy for advanced head and neck cancers.

PubMed

Huang, Pin-I; Chang, Ju-Fang; Kirn, David H; Liu, Ta-Chiang

2009-06-01

Head and neck cancers usually present with advanced disease and novel therapies are urgently needed. Genetic therapy aims at restoring malfunctioned tumor suppressor gene(s) or introducing proapoptotic genes. Oncolytic virotherapeutics induce multiple cycles of cancer-specific virus replication, followed by oncolysis, virus spreading and infection of adjacent cancer cells. Oncolytic viruses can also be armed to express therapeutic transgene(s). Recent advances in preclinical and clinical studies are revealing the potential of both therapeutic classes for advanced head and neck cancers, including the approval of two products (Gendicine and H101) by a governmental agency. This review summarizes the available clinical data to date and discusses the challenges and future directions.

An airline study of advanced technology requirements for advanced high speed commercial engines. 3: Propulsion system requirements

NASA Technical Reports Server (NTRS)

Sallee, G. P.

1973-01-01

The advanced technology requirements for an advanced high speed commercial transport engine are presented. The results of the phase 3 effort cover the requirements and objectives for future aircraft propulsion systems. These requirements reflect the results of the Task 1 and 2 efforts and serve as a baseline for future evaluations, specification development efforts, contract/purchase agreements, and operational plans for future subsonic commercial engines. This report is divided into five major sections: (1) management objectives for commercial propulsion systems, (2) performance requirements for commercial transport propulsion systems, (3) design criteria for future transport engines, (4) design requirements for powerplant packages, and (5) testing.

Perceptions and types of support coming from families caring for patients suffering from advanced illness in Kinshasa, Democratic Republic of Congo.

PubMed

Lofandjola, Jacques Masumbuku; Sumaili, Ernest Kiswaya; Mairiaux, Philippe; Petermans, Jean

2017-08-01

Perceptions of families who take care of patients suffering from advanced illness are rarely considered in Kinshasa medical practices; nevertheless, these families are the main actors involved in such care. The objective of this present study was to illustrate, in a Congolese context, the perceptions of families on the care of patients suffering from advanced illness, and to identify the possible aids provided by healthcare facilities. A qualitative study was performed among focus groups in six hospitals in Kinshasa. Each group included eight members. We gathered factors that could negatively influence the care of a patient suffering from advanced disease. Such factors included: scarcity of and inaccessibility to painkillers, economic resilience, poor quality treatment, lack of psychological counselling, seeking alternative solutions and poor communication between caregivers and patients. In contrast, the study also showed that relatives caring for these patients often receive support from the wider family and from cult members. This study focuses on the miscommunication between healthcare workers and patients, poor management in advanced illness as well as a lack of psychological support from caregivers. The findings can serve as basis for further research in palliative care.

The Advanced Gamma-ray Imaging System (AGIS)-Simulation Studies

NASA Astrophysics Data System (ADS)

Maier, G.; Buckley, J.; Bugaev, V.; Fegan, S.; Funk, S.; Konopelko, A.; Vassiliev, V. V.

2008-12-01

The Advanced Gamma-ray Imaging System (AGIS) is a US-led concept for a next-generation instrument in ground-based very-high-energy gamma-ray astronomy. The most important design requirement for AGIS is a sensitivity of about 10 times greater than current observatories like Veritas, H.E.S.S or MAGIC. We present results of simulation studies of various possible designs for AGIS. The primary characteristics of the array performance, collecting area, angular resolution, background rejection, and sensitivity are discussed.

Transmission research activities at NASA Lewis Research Center

NASA Technical Reports Server (NTRS)

Lewicki, D. G.

1990-01-01

A joint research program, to advance the technology of rotorcraft transmissions, consists of analytical and experimental efforts to achieve the overall goals of reducing transmission weight and noise, while increasing life and reliability. Recent activities in the areas of transmission and related component research are highlighted. Current areas include specific technologies in support of military rotary wing aviation, gearing technology, transmission noise reduction studies, a recent interest in gearbox diagnostics, and advanced transmission system studies. Results of recent activities are presented along with near term research plans.

Short Stature, Accelerated Bone Maturation, and Early Growth Cessation Due to Heterozygous Aggrecan Mutations

PubMed Central

Nilsson, Ola; Guo, Michael H.; Dunbar, Nancy; Popovic, Jadranka; Flynn, Daniel; Jacobsen, Christina; Lui, Julian C.; Hirschhorn, Joel N.; Baron, Jeffrey

2014-01-01

Context: Many children with idiopathic short stature have a delayed bone age. Idiopathic short stature with advanced bone age is far less common. Objective: The aim was to identify underlying genetic causes of short stature with advanced bone age. Setting and Design: We used whole-exome sequencing to study three families with autosomal-dominant short stature, advanced bone age, and premature growth cessation. Results: Affected individuals presented with short stature [adult heights −2.3 to −4.2 standard deviation scores (SDS)] with histories of early growth cessation or childhood short stature (height SDS −1.9 to −3.5 SDS), advancement of bone age, and normal endocrine evaluations. Whole-exome sequencing identified novel heterozygous variants in ACAN, which encodes aggrecan, a proteoglycan in the extracellular matrix of growth plate and other cartilaginous tissues. The variants were present in all affected, but in no unaffected, family members. In Family 1, a novel frameshift mutation in exon 3 (c.272delA) was identified, which is predicted to cause early truncation of the aggrecan protein. In Family 2, a base-pair substitution was found in a highly conserved location within a splice donor site (c.2026+1G>A), which is also likely to alter the amino acid sequence of a large portion of the protein. In Family 3, a missense variant (c.7064T>C) in exon 14 affects a highly conserved residue (L2355P) and is strongly predicted to perturb protein function. Conclusions: Our study demonstrates that heterozygous mutations in ACAN can cause a mild skeletal dysplasia, which presents clinically as short stature with advanced bone age. The accelerating effect on skeletal maturation has not previously been noted in the few prior reports of human ACAN mutations. Our findings thus expand the spectrum of ACAN defects and provide a new molecular genetic etiology for the unusual child who presents with short stature and accelerated skeletal maturation. PMID:24762113

Reinstating nursing administration graduate study in federal nurse traineeships.

PubMed

Kersbergen, A L

1994-01-01

In 1992, the federal guidelines for funding nurse traineeships were amended to exclude nurses who pursue advanced degrees in nursing administration. This legislation expires soon, and final drafting of new legislation will be completed during the summer of 1994. The author presents information to use in advocating for reinstatement of nursing administration students as potential recipients of federal nurse traineeship dollars for advanced education.

FY04 Advanced Life Support Architecture and Technology Studies: Mid-Year Presentation

NASA Technical Reports Server (NTRS)

Lange, Kevin; Anderson, Molly; Duffield, Bruce; Hanford, Tony; Jeng, Frank

2004-01-01

Long-Term Objective: Identify optimal advanced life support system designs that meet existing and projected requirements for future human spaceflight missions. a) Include failure-tolerance, reliability, and safe-haven requirements. b) Compare designs based on multiple criteria including equivalent system mass (ESM), technology readiness level (TRL), simplicity, commonality, etc. c) Develop and evaluate new, more optimal, architecture concepts and technology applications.

Improving of Reading in High Schools: Outcomes of Ramp Up to Advanced Literacy in a Large Urban District

ERIC Educational Resources Information Center

Munoz, Marco A.

2007-01-01

The purpose of the present study was to examine the effectiveness of Ramp Up to Advanced Literacy, an unbundled Comprehensive School Reform (CSR) model, on the reading achievement of ninth grade students in a large urban school district in Kentucky. Using a pre- and posttest impact evaluation design, data from participating and non-participating…

Study of structural design concepts for an arrow wing supersonic transport configuration, volume 1. Tasks 1 and 2

NASA Technical Reports Server (NTRS)

1976-01-01

A structural design study was made, based on a 1975 level of technology, to assess the relative merits of structural concepts and materials for an advanced supersonic transport cruising at Mach 2.7. Preliminary studies were made to insure compliance of the configuration with general design criteria, to integrate the propulsion system with the airframe, to select structural concepts and materials, and to define an efficient structural arrangement. An advanced computerized structural design system was used, in conjunction with a relatively large, complex finite element model, for detailed analysis and sizing of structural members to satisfy strength and flutter criteria. A baseline aircraft design was developed for assessment of current technology and for use in future studies of aerostructural trades, and application of advanced technology. Criteria, analysis methods, and results are presented.

A feasibility study for advanced technology integration for general aviation

NASA Technical Reports Server (NTRS)

Kohlman, D. L.; Matsuyama, G. T.; Hawley, K. E.; Meredith, P. T.

1980-01-01

An investigation was conducted to identify candidate technologies and specific developments which offer greatest promise for improving safety, fuel efficiency, performance, and utility of general aviation airplanes. Interviews were conducted with general aviation airframe and systems manufacturers and NASA research centers. The following technologies were evaluated for use in airplane design tradeoff studies conducted during the study: avionics, aerodynamics, configurations, structures, flight controls, and propulsion. Based on industry interviews and design tradeoff studies, several recommendations were made for further high payoff research. The most attractive technologies for use by the general aviation industry appear to be advanced engines, composite materials, natural laminar flow airfoils, and advanced integrated avionics systems. The integration of these technologies in airplane design can yield significant increases in speeds, ranges, and payloads over present aircraft with 40 percent to 50 percent reductions in fuel used.

CVO driver fatigue and complex in-vehicle systems

DOT National Transportation Integrated Search

1997-10-01

As one of a series of studies aimed at gathering data to develop human factors design guidelines for Advanced Traveler Information Systems (ATIS) and Commercial Vehicle Operations (CVO), the present study utilized a driving simulator to study CVO dri...

ASTP RBCC Activities

NASA Technical Reports Server (NTRS)

Nelson, Karl W.; McArthur, Craig; Leopard, Larry (Technical Monitor)

2000-01-01

This presentation reviews the activities of the Advanced Space Transportation Program (ASTP) in the development of Rocket-Based Combined Cycle (RBCC)technology. The document consist of the presentation slides for a talk scheduled to be given to the World Aviation Congress and Exhibit of SAE. Included in the review is discussion of recent accomplishments in the area of Advanced Reusable technologies (ART), which includes work in flowpath testing, and system studies of the various vehicle/engine combinations including RBCC, Turbine Based Combined Cycle (TBCC) and Pulsed Detonation Engine (PDE). Pictures of the proposed RBCC Flowpaths are included. The next steps in the development process are reviewed.

Third International Workshop on Ion Mobility Spectrometry

NASA Technical Reports Server (NTRS)

Cross, John H. (Editor)

1995-01-01

Basic research in ion mobility spectrometry has given rise to rapid advancement in hardware development and applications. The Third International Workshop on Ion Mobility Spectrometry (IMS) was held October 16-19, 1994, at Johnson Space Center to provide a forum for investigators to present the most recent results of both basic and applied IMS research. Presenters included manufacturers and various users, including military research organizations and drug enforcement agencies. Thirty papers were given in the following five sessions: Fundamental IMS Studies, Instrument Development, Hyphenated IMS Techniques, Applications, and Data Reduction and Signal Processing. Advances in hardware development, software development, and user applications are described.

NASA Hydrogen Research for Spaceport and Space Based Applications

NASA Technical Reports Server (NTRS)

Anderson, Tim

2006-01-01

The activities presented are a broad based approach to advancing key hydrogen related technologies in areas such as hydrogen production, distributed sensors for hydrogen-leak detection, laser instrumentation for hydrogen-leak detection, and cryogenic transport and storage. Presented are the results form 15 research projects, education, and outreach activities, system and trade studies, and project management. The work will aid in advancing the state-of-the-art for several critical technologies related to the implementation of a hydrogen infrastructure. Activities conducted are relevant to a number of propulsion and power systems for terrestrial, aeronautics, and aerospace applications.

Systematic review with meta-analysis: the incidence of advanced neoplasia after polypectomy in patients with and without low-risk adenomas.

PubMed

Hassan, C; Gimeno-García, A; Kalager, M; Spada, C; Zullo, A; Costamagna, G; Senore, C; Rex, D K; Quintero, E

2014-05-01

Patients with one to two tubular adenomas <1 cm in size without high-grade dysplasia (low-risk group) are considered at low risk for colorectal cancer. However, it is uncertain whether they have the same risk of subsequent advanced neoplasia as those with no neoplasia at baseline colonoscopy. To compare incidence of metachronous advanced neoplasia between patients in the low-risk adenoma group and those without neoplasia at index colonoscopy. Relevant publications were identified by MEDLINE/EMBASE and other databases for the period 1992-2013. Studies comparing the incidence of post-polypectomy advanced neoplasia (adenomas ≥10 mm/high-grade dysplasia/villous or cancer) between the low-risk group and patients without colorectal neoplasia at the first colonoscopy were included. Detection rates for advanced neoplasia at endoscopic surveillance were extracted. Study quality was ascertained according to Newcastle-Ottawa Scale. Forest plot was produced based on random-effect models. Inter-study heterogeneity was assessed using the I(2) statistic. Seven studies provided data on 11 387 patients. Mean surveillance periods ranged between 2 and 5 years. Altogether, 267 patients with post-polypectomy advanced neoplasia were detected in the two groups. The incidence of advanced neoplasia was 1.6% (119/7308) in those without neoplasia and 3.6% (148/4079) in those with low-risk adenoma, respectively, corresponding to a relative risk of 1.8 (95% CI: 1.3-2.6). Inter-study heterogeneity was only moderate (I(2) : 37%). No publication bias was present. Patients with low-risk adenomas at baseline had a higher risk of metachronous advanced neoplasia than the group with no adenomas at baseline, though the absolute risk was low in both groups. © 2014 John Wiley & Sons Ltd.

Do patients discharged from advanced practice physiotherapy-led clinics re-present to specialist medical services?

PubMed

Chang, Angela T; Gavaghan, Belinda; O'Leary, Shaun; McBride, Liza-Jane; Raymer, Maree

2017-05-15

Objective The aim of the present study was to determine the rates of re-referral to specialist out-patient clinics for patients previously managed and discharged from an advanced practice physiotherapy-led service in three metropolitan hospitals. Methods A retrospective audit was undertaken of 462 patient cases with non-urgent musculoskeletal conditions discharged between 1 April 2014 and 30 March 2015 from three metropolitan hospitals. These patients had been discharged from the physiotherapy-led service without requiring specialist medical review. Rates and patterns of re-referral to specialist orthopaedic, neurosurgical, chronic pain, or rheumatology services within 12 months of discharge were investigated. Results Forty-six of the 462 patients (10.0%) who were managed by the physiotherapy-led service were re-referred to specialist medical orthopaedic, neurosurgical, chronic pain or rheumatology departments within 12 months of discharge. Only 22 of these patients (4.8%) were re-referred for the same condition as managed previously and discharged. Conclusions Ninety-five per cent of patients with non-urgent musculoskeletal conditions managed by an advanced practice physiotherapy-led service at three metropolitan hospitals did not re-present to access public specialist medical services for the same condition within 12 months of discharge. This is the first time that re-presentation rates have been reported for patients managed in advanced practice physiotherapy services and the findings support the effectiveness of these models of care in managing demand for speciality out-patient services. What is known about the topic? Advanced practice physiotherapy-led services have been implemented to address the needs of patients referred with non-urgent musculoskeletal conditions to hospital specialist out-patient services. Although this model is widely used in Australia, there has been very little information about whether patients managed in these services subsequently re-present for further specialist medical care. What does this paper add? This paper identifies that the majority (95%) of patients managed by an advanced practice physiotherapy-led service did not re-present for further medical care for the same condition within 12 months of discharge. What are the implications for practitioners? This paper supports the use of advanced practice physiotherapy-led services in the management of overburdened neurosurgical and orthopaedic specialist out-patient waiting lists.

Advanced boundary layer transition measurement methods for flight applications

NASA Technical Reports Server (NTRS)

Holmes, B. J.; Croom, C. C.; Gail, P. D.; Manuel, G. S.; Carraway, D. L.

1986-01-01

In modern laminar flow flight research, it is important to understand the specific cause(s) of laminar to turbulent boundary-layer transition. Such information is crucial to the exploration of the limits of practical application of laminar flow for drag reduction on aircraft. The transition modes of interest in current flight investigations include the viscous Tollmien-Schlichting instability, the inflectional instability at laminar separation, and the crossflow inflectional instability, as well as others. This paper presents the results to date of research on advanced devices and methods used for the study of laminar boundary-layer transition phenomena in the flight environment. Recent advancements in the development of arrayed hot-film devices and of a new flow visualization method are discussed. Arrayed hot-film devices have been designed to detect the presence of laminar separation, and of crossflow vorticity. The advanced flow visualization method utilizes color changes in liquid-crystal coatings to detect boundary-layer transition at high altitude flight conditions. Flight and wind tunnel data are presented to illustrate the design and operation of these advanced methods. These new research tools provide information on disturbance growth and transition mode which is essential to furthering our understanding of practical design limits for applications of laminar flow technology.

Advancing alternatives analysis: The role of predictive toxicology in selecting safer chemical products and processes.

PubMed

Malloy, Timothy; Zaunbrecher, Virginia; Beryt, Elizabeth; Judson, Richard; Tice, Raymond; Allard, Patrick; Blake, Ann; Cote, Ila; Godwin, Hilary; Heine, Lauren; Kerzic, Patrick; Kostal, Jakub; Marchant, Gary; McPartland, Jennifer; Moran, Kelly; Nel, Andre; Ogunseitan, Oladele; Rossi, Mark; Thayer, Kristina; Tickner, Joel; Whittaker, Margaret; Zarker, Ken

2017-09-01

Alternatives analysis (AA) is a method used in regulation and product design to identify, assess, and evaluate the safety and viability of potential substitutes for hazardous chemicals. It requires toxicological data for the existing chemical and potential alternatives. Predictive toxicology uses in silico and in vitro approaches, computational models, and other tools to expedite toxicological data generation in a more cost-effective manner than traditional approaches. The present article briefly reviews the challenges associated with using predictive toxicology in regulatory AA, then presents 4 recommendations for its advancement. It recommends using case studies to advance the integration of predictive toxicology into AA, adopting a stepwise process to employing predictive toxicology in AA beginning with prioritization of chemicals of concern, leveraging existing resources to advance the integration of predictive toxicology into the practice of AA, and supporting transdisciplinary efforts. The further incorporation of predictive toxicology into AA would advance the ability of companies and regulators to select alternatives to harmful ingredients, and potentially increase the use of predictive toxicology in regulation more broadly. Integr Environ Assess Manag 2017;13:915-925. © 2017 SETAC. © 2017 SETAC.

Management of advanced pancreatic cancer with gemcitabine plus erlotinib: efficacy and safety results in clinical practice.

PubMed

Diaz Beveridge, Robert; Alcolea, Vicent; Aparicio, Jorge; Segura, Ángel; García, Jose; Corbellas, Miguel; Fonfría, María; Giménez, Alejandra; Montalar, Joaquin

2014-01-10

The combination of gemcitabine and erlotinib is a standard first-line treatment for unresectable, locally advanced or metastatic pancreatic cancer. We reviewed our single centre experience to assess its efficacy and toxicity in clinical practice. Clinical records of patients with unresectable, locally advanced or metastatic pancreatic cancer who were treated with the combination of gemcitabine and erlotinib were reviewed. Univariate survival analysis and multivariate analysis were carried out to indentify independent predictors factors of overall survival. Our series included 55 patients. Overall disease control rate was 47%: 5% of patients presented complete response, 20% partial response and 22% stable disease. Median overall survival was 8.3 months). Cox regression analysis indicated that performance status and locally advanced versus metastatic disease were independent factors of overall survival. Patients who developed acne-like rash toxicity, related to erlotinib administration, presented a higher survival than those patients who did not develop this toxicity. Gemcitabine plus erlotinib doublet is active in our series of patients with advanced pancreatic cancer. This study provides efficacy and safety results similar to those of the pivotal phase III clinical trial that tested the same combination.

Creating an advance-care-planning decision aid for high-risk surgery: a qualitative study

PubMed Central

2014-01-01

Background High-risk surgery patients may lose decision-making capacity as a result of surgical complications. Advance care planning prior to surgery may be beneficial, but remains controversial and is hindered by a lack of appropriate decision aids. This study sought to examine stakeholders’ views on the appropriateness of using decision aids, in general, to support advance care planning among high-risk surgery populations and the design of such a decision aid. Methods Key informants were recruited through purposive and snowball sampling. Semi-structured interviews were conducted by phone until data collected reached theoretical saturation. Key informants were asked to discuss their thoughts about advance care planning and interventions to support advance care planning, particularly for this population. Researchers took de-identified notes that were analyzed for emerging concordant, discordant, and recurrent themes using interpretative phenomenological analysis. Results Key informants described the importance of initiating advance care planning preoperatively, despite potential challenges present in surgical settings. In general, decision aids were viewed as an appropriate approach to support advance care planning for this population. A recipe emerged from the data that outlines tools, ingredients, and tips for success that are needed to design an advance care planning decision aid for high-risk surgical settings. Conclusions Stakeholders supported incorporating advance care planning in high-risk surgical settings and endorsed the appropriateness of using decision aids to do so. Findings will inform the next stages of developing the first advance care planning decision aid for high-risk surgery patients. PMID:25067908

Creating an advance-care-planning decision aid for high-risk surgery: a qualitative study.

PubMed

Schuster, Anne Lr; Aslakson, Rebecca A; Bridges, John Fp

2014-01-01

High-risk surgery patients may lose decision-making capacity as a result of surgical complications. Advance care planning prior to surgery may be beneficial, but remains controversial and is hindered by a lack of appropriate decision aids. This study sought to examine stakeholders' views on the appropriateness of using decision aids, in general, to support advance care planning among high-risk surgery populations and the design of such a decision aid. Key informants were recruited through purposive and snowball sampling. Semi-structured interviews were conducted by phone until data collected reached theoretical saturation. Key informants were asked to discuss their thoughts about advance care planning and interventions to support advance care planning, particularly for this population. Researchers took de-identified notes that were analyzed for emerging concordant, discordant, and recurrent themes using interpretative phenomenological analysis. Key informants described the importance of initiating advance care planning preoperatively, despite potential challenges present in surgical settings. In general, decision aids were viewed as an appropriate approach to support advance care planning for this population. A recipe emerged from the data that outlines tools, ingredients, and tips for success that are needed to design an advance care planning decision aid for high-risk surgical settings. Stakeholders supported incorporating advance care planning in high-risk surgical settings and endorsed the appropriateness of using decision aids to do so. Findings will inform the next stages of developing the first advance care planning decision aid for high-risk surgery patients.

Novel MoSe2 hierarchical microspheres for applications in visible-light-driven advanced oxidation processes.

PubMed

Dai, Chu; Qing, Enping; Li, Yong; Zhou, Zhaoxin; Yang, Chao; Tian, Xike; Wang, Yanxin

2015-12-21

Advanced oxidation processes as a green technology have been adopted by combining the semiconductor catalyst MoSe2 with H2O2 under visible radiation. And novel three-dimensional self-assembled molybdenum diselenide (MoSe2) hierarchical microspheres from nanosheets were produced by using organic, selenium cyanoacetic acid sodium (NCSeCH2COONa) as the source of Se. The obtained products possess good crystallinity and present hierarchical structures with the average diameter of 1 μm. The band gap of MoSe2 microspheres is 1.68 eV and they present excellent photocatalytic activity under visible light irradiation in the MoSe2-H2O2 system. This effective photocatalytic mechanism was investigated in this study and can be attributed to visible-light-driven advanced oxidation processes.

Advance Directives and Powers of Attorney in Intensive Care Patients.

PubMed

de Heer, Geraldine; Saugel, Bernd; Sensen, Barbara; Rübsteck, Charlotte; Pinnschmidt, Hans O; Kluge, Stefan

2017-06-05

Advance directives and powers of attorney are increasingly common, yet data on their use in clinical situations remain sparse. In this single center cross-sectional study, we collected data by questionnaire from 1004 intensive care patients in a university hospital. The frequencies of advance directives and powers of attorney were determined, and the factors affecting them were studied with multivariate logistic regression analysis. Usable data were obtained from 998 patients. 51.3% stated that they had prepared a document of at least one of these two kinds. Among them, 39.6% stated that they had given the relevant document(s) to the hospital, yet such documents were present in the patient's hospital record for only 23%. 508 patients stated their reasons for preparing an advance directive or a power of attorney: the most common reason (48%) was the fear of being at other people's mercy, of the lack of self-determination, or of medical overtreatment. The most important factors associated with a patient's statement that he/she had prepared such a document were advanced age (advance directive: 1.022 [1.009; 1.036], p = 0.001; power of attorney: 1.027 [1.014; 1.040], p<0.001) and elective admission to the hospital (advance directive: 1.622 [1.138; 2.311], p<0.007; power of attorney: 1.459 [1.049; 2.030], p = 0.025). 39.8% of the advance directives and 44.1% of the powers of attorney that were present in the hospital records were poorly interpretable because of the incomplete filling-out of preprinted forms. Half of the patients who did not have such a document had already thought of preparing one, but had not yet done so. For patients hospitalized in intensive care units, there should be early discussion about the presence or absence of documents of these kinds and early evaluation of the patient's concrete wishes in critical situations. Future studies are needed to determine how best to assure that these documents will be correctly prepared and then given over to hospital staff so that they can take their place in the patient's record.

Advanced Parkinson's disease: clinical characteristics and treatment. Part II.

PubMed

Kulisevsky, J; Luquin, M R; Arbelo, J M; Burguera, J A; Carrillo, F; Castro, A; Chacón, J; García-Ruiz, P J; Lezcano, E; Mir, P; Martinez-Castrillo, J C; Martínez-Torres, I; Puente, V; Sesar, A; Valldeoriola-Serra, F; Yañez, R

2013-01-01

Many patients who have had Parkinson's disease (PD) for several years will present severe motor fluctuations and dyskinesias which require more aggressive therapies. The different approaches which are now available include deep brain stimulation of the subthalamic nucleus or medial globus pallidus, subcutaneous infusion of apomorphine, and intestinal infusion of levodopa-carbidopa. To define the indications and results for the 3 available therapies for advanced PD. Exhaustive review of the literature concerning the indications and results of deep brain stimulation, subcutaneous apomorphine infusion and duodenal infusion of levodopa/carbidopa gel to treat patients with advanced Parkinson disease. Although numerous studies have confirmed the efficacy of the 3 different therapies in advanced PD, there are no comparative studies that would allow us to define the best candidate for each technique. Copyright © 2013 Sociedad Española de Neurología. Published by Elsevier Espana. All rights reserved.

A white paper: Operational efficiency. New approaches to future propulsion systems

NASA Technical Reports Server (NTRS)

Rhodes, Russel; Wong, George

1991-01-01

Advanced launch systems for the next generation of space transportation systems (1995 to 2010) must deliver large payloads (125,000 to 500,000 lbs) to low earth orbit (LEO) at one tenth of today's cost, or 300 to 400 $/lb of payload. This cost represents an order of magnitude reduction from the Titan unmanned vehicle cost of delivering payload to orbit. To achieve this sizable reduction, the operations cost as well as the engine cost must both be lower than current engine system. The Advanced Launch System (ALS) is studying advanced engine designs, such as the Space Transportation Main Engine (STME), which has achieved notable reduction in cost. The results are presented of a current study wherein another level of cost reduction can be achieved by designing the propulsion module utilizing these advanced engines for enhanced operations efficiency and reduced operations cost.

The Development of Nanotechnologies and Advanced Materials Industry in Science and Entrepreneurship: Scientific Indicators. A Case Study of Latvia (Part Three)

NASA Astrophysics Data System (ADS)

Geipele, S.; Geipele, I.; Kauskale, L.; Zeltins, N.; Staube, T.; Pudzis, E.

2017-10-01

The present scientific paper is the third part and continuation of the indepth scientific study of the developed system of engineering economic indicators, where the authors obtain results from the scientific research presented in a series of works on the development of the nanotechnologies and advanced materials industry in science and entrepreneurship in Latvia. Part three determines the crucial scientific indicators of the development of nano-field at the macro, micro, and meso development levels of the economic environment in Latvia. The paper provides the interaction of new identified indicators of nanofield in terms of further scientific and practical activities. Latvia is analysed in comparison with other countries in the world.

Navy Applications Experience with Small Wind Power Systems

DTIC Science & Technology

1985-05-01

present state-of-the-art in small WECS technology, including environmental concerns, is reviewed. Also presented is how the technology is advancing to...environmental concerns, is reviewed. Also presented is how the technology is advancing to improve reliability and avail- ability for effectively using...VAWT technology is still in its early stages of development. The horizontal-axis wind turbine (HAWT) technology has advanced to third and fourth

AMS in drug development at GSK

NASA Astrophysics Data System (ADS)

Young, G. C.; Ellis, W. J.

2007-06-01

A history of the use of AMS in GSK studies spanning the last 8 years (1998-2005) is presented, including use in pilot studies through to clinical, animal and in vitro studies. A brief summary of the status of GSK's in-house AMS capability is outlined and views on the future of AMS in GSK are presented, including potential impact on drug development and potential advances in AMS technology.

Advanced extravehicular protective systems for shuttle, space station, lunar base and Mars missions.

NASA Technical Reports Server (NTRS)

Heimlich, P. F.; Sutton, J. G.; Tepper, E. H.

1972-01-01

Advances in extravehicular life support system technology will directly influence future space mission reliability and maintainability considerations. To identify required new technology areas, an appraisal of advanced portable life support system and subsystem concepts was conducted. Emphasis was placed on thermal control and combined CO2 control/O2 supply subsystems for both primary and emergency systems. A description of study methodology, concept evaluation techniques, specification requirements, and selected subsystems and systems are presented. New technology recommendations encompassing thermal control, CO2 control and O2 supply subsystems are also contained herein.

Propulsion issues for advanced orbit transfer vehicles

NASA Technical Reports Server (NTRS)

Cooper, L. P.

1984-01-01

Studies of the United States Space Transportation System show that in the mid to late 1990s expanded capabilities for orbital transfer vehicles (OTV) will be needed to meet increased payload requirements for transporting materials and possibly men to geosynchronous orbit. Discussion and observations relative to the propulsion system issues of space basing, aeroassist compatibility, man ratability and enhanced payload delivery capability are presented. These issues will require resolution prior to the development of a propulsion system for the advanced OTV. The NASA program in support of advanced propulsion for an OTV is briefly described along with conceptual engine design characteristics.

The development of an advanced generic solar dynamic heat receiver thermal model

NASA Technical Reports Server (NTRS)

Wu, Y. C.; Roschke, E. J.; Kohout, L.

1988-01-01

An advanced generic solar dynamic heat receiver thermal model under development which can analyze both orbital transient and orbital average conditions is discussed. This model can be used to study advanced receiver concepts, evaluate receiver concepts under development, analyze receiver thermal characteristics under various operational conditions, and evaluate solar dynamic system thermal performances in various orbit conditions. The model and the basic considerations that led to its creation are described, and results based on a set of baseline orbit, configuration, and operational conditions are presented to demonstrate the working of the receiver model.

Proceedings of the Eleventh Advanced Communications Technology Satellite Propagation Studies Workshop (APSW 11)

NASA Technical Reports Server (NTRS)

Golshan, Nasser (Editor); Ho, Christian (Editor)

1998-01-01

The Advanced Communications Technology Satellite Propagation Studies Workshop (APSW) is convened each year to present the results of the Advanced Communications Technology Satellite (ACTS) Ka-band propagation campaign. Representatives from the space community including industry, academia, and government who are interested in radiowave propagation at Ka-band are invited to APSW for discussions and exchange of information. The ACTS Propagation campaign will complete five years of Ka-Band data collection at seven sites in North America by December 31, 1998. Through this effort, NASA is making a major contribution to the effective utilization of this band by providing timely propagation data and models for predicting the performance of Ka-band links between space and ground.

Emergency presentation of colorectal cancer in Northwestern Saudi Arabia.

PubMed

Albalawi, Ibrahim A; Abdullah, Ahmad A; Mohammed, Mohammed E

2017-05-01

To investigate the frequency and clinical characteristics of emergency presentation of colorectal carcinoma (CRC) in Tabuk Region of Saudi Arabia.  Methods: This is a retrospective, descriptive hospital-based study. All cases with CRC that presented to the main referral hospitals in Tabuk, Saudi Arabia between 2010 and 2015 were retrieved. The relevant hospitals are: King Salman Military Hospital, King Khalid Hospital, and King Fahad Hospital.  Results: Seventy-three patients were included in the study. Twenty-two patients presented emergency constituting 30.6% of the total. Emergency CRC presentation was more common in elderly patients (81.8%), but a greater proportion of young patients was also affected (40% versus 29% in elderly patients). The disease is more common in females (37%) than males (26.7%) and intestinal obstruction was the sole form of presentation. Patients presenting emergency had more right-sided (61.9%) than left-sided tumors (30.2%). Advanced presentation with metastasis was noted in 40% of the patients presenting acutely. Conclusion: Emergency CRC presentation is common in the Tabuk region. Patients tend to present at an advanced stage, which necessitates an endeavor to detect the disease in its early stages, possibly through initiation of health education programs and suitable screening projects.

Advanced Telescopes and Observatories Capability Roadmap Presentation to the NRC

NASA Technical Reports Server (NTRS)

2005-01-01

This viewgraph presentation provides an overview of the NASA Advanced Planning and Integration Office (APIO) roadmap for developing technological capabilities for telescopes and observatories in the following areas: Optics; Wavefront Sensing and Control and Interferometry; Distributed and Advanced Spacecraft; Large Precision Structures; Cryogenic and Thermal Control Systems; Infrastructure.

Making Advanced Computer Science Topics More Accessible through Interactive Technologies

ERIC Educational Resources Information Center

Shao, Kun; Maher, Peter

2012-01-01

Purpose: Teaching advanced technical concepts in a computer science program to students of different technical backgrounds presents many challenges. The purpose of this paper is to present a detailed experimental pedagogy in teaching advanced computer science topics, such as computer networking, telecommunications and data structures using…

THE LONDON LOW EMISSION ZONE BASELINE STUDY

EPA Science Inventory

The investigators hope that the LEZ baseline study will present a creative effort to lay the groundwork for studying spatial and temporal changes in air pollutant concentrations and health outcomes in advance of a major regulatory intervention. It is hope that the study wil...

Energy Conversion Alternatives Study (ECAS), General Electric Phase 1. Volume 2: Advanced energy conversion systems. Part 1: Open-cycle gas turbines

NASA Technical Reports Server (NTRS)

Brown, D. H.; Corman, J. C.

1976-01-01

Ten energy conversion systems are defined and analyzed in terms of efficiency. These include: open-cycle gas turbine recuperative; open-cycle gas turbine; closed-cycle gas turbine; supercritical CO2 cycle; advanced steam cycle; liquid metal topping cycle; open-cycle MHD; closed-cycle inert gas MHD; closed-cycle liquid metal MHD; and fuel cells. Results are presented.

Performance estimation for a highly loaded eight-blade propeller combined with an advanced technology turboshaft engine

NASA Technical Reports Server (NTRS)

Morris, S. J., Jr.

1979-01-01

Performance estimation, weights, and scaling laws for an eight-blade highly loaded propeller combined with an advanced turboshaft engine are presented. The data are useful for planned aircraft mission studies using the turboprop propulsion system. Comparisons are made between the performance of the 1990+ technology turboprop propulsion system and the performance of both a current technology turbofan and an 1990+ technology turbofan.

MSFC Advanced Concepts Office and the Iterative Launch Vehicle Concept Method

NASA Technical Reports Server (NTRS)

Creech, Dennis

2011-01-01

This slide presentation reviews the work of the Advanced Concepts Office (ACO) at Marshall Space Flight Center (MSFC) with particular emphasis on the method used to model launch vehicles using INTegrated ROcket Sizing (INTROS), a modeling system that assists in establishing the launch concept design, and stage sizing, and facilitates the integration of exterior analytic efforts, vehicle architecture studies, and technology and system trades and parameter sensitivities.

Managing motivation and developing job satisfaction in the health care work environment.

PubMed

Timmreck, T C

2001-09-01

Motivation relies on internal/intrinsic and external factors to stimulate work-related behavior. This article presents an overview of Herzberg's motivation-hygiene theory and reports on the results of a study of 99 health service midmanagers. The participants completed a survey asking whether they believe in motivational factors and if they use them. Several of Herzberg's motivational factors were included (achievement, recognition, work itself, responsibility, advancement) plus several other motivational factors including money/pay, self-interest, seek a higher standard of living. Negative factors included guilt, threats, power, and control. This article presents motivation factors, such as achievement, recognition, work itself, responsibility, advancement, growth, self-interest, pay, and belief in successful outcome, that were presented to 99 mid-level health services administrators.

Technological Ecosystems in Health Informatics: A Brief Review Article.

PubMed

Wu, Zhongmei; Zhang, Xiuxiu; Chen, Ying; Zhang, Yan

2016-09-01

The existing models of information technology in health sciences have full scope of betterment and extension. The high demand pressures, public expectations, advanced platforms all collectively contribute towards hospital environment, which has to be kept in kind while designing of advanced technological ecosystem for information technology. Moreover, for the smooth conduct and operation of information system advanced management avenues are also essential in hospitals. It is the top priority of every hospital to deal with the essential needs of care for patients within the available resources of human and financial outputs. In these situations of high demand, the technological ecosystems in health informatics come in to play and prove its importance and role. The present review article would enlighten all these aspects of these ecosystems in hospital management and health care informatics. We searched the electronic database of MEDLINE, EMBASE, and PubMed for clinical controlled trials, pre-clinical studies reporting utilizaiono of ecosysyem advances in health information technology. The primary outcome of eligible studies included confirmation of importance and role of advances ecosystems in health informatics. It was observed that technological ecosystems are the backbone of health informatics. Advancements in technological ecosystems are essential for proper functioning of health information system in clinical setting.

Comparison of Video Head Impulse Test and Caloric Reflex Test in advanced unilateral definite Menière's disease.

PubMed

Rubin, F; Simon, F; Verillaud, B; Herman, P; Kania, R; Hautefort, C

2018-06-01

There have been very few studies of the Video Head Impulse Test (VHIT) in patients with Menière's Disease (MD). Some reported 100% normal VHIT results, others not. These discrepancies may be due to differences in severity. The present study compared VHIT and caloric reflex test results in advanced unilateral definite MD. A prospective study included 37 consecutive patients, with a mean age of 56±12 years. Mean hearing loss was 59±18dB HL; 12 patients were subject to Tumarkin's otolithic crises. Abnormal caloric reflex was defined as ≥20% deficit, and abnormal VHIT as presence of saccades or <0.64 gain in vertical semicircular canals and <0.78 in horizontal canals. All patients had normal VHIT results, and 3 had normal caloric reflex; mean caloric reflex deficit was 45%. The present study is the only one to use the August 2015 updated definition of MD. The results showed that, outside of episodes of crisis, VHIT was normal during advanced unilateral definite MD, in contrast to abnormal caloric reflex. This feature could help distinguish MD from other inner ear diseases, and it would be interesting to try to confirm this hypothesis by studying MD patients. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Modeling of UH-60A Hub Accelerations with Neural Networks

NASA Technical Reports Server (NTRS)

Kottapalli, Sesi

2002-01-01

Neural network relationships between the full-scale, flight test hub accelerations and the corresponding three N/rev pilot floor vibration components (vertical, lateral, and longitudinal) are studied. The present quantitative effort on the UH-60A Black Hawk hub accelerations considers the lateral and longitudinal vibrations. An earlier study had considered the vertical vibration. The NASA/Army UH-60A Airloads Program flight test database is used. A physics based "maneuver-effect-factor (MEF)", derived using the roll-angle and the pitch-rate, is used. Fundamentally, the lateral vibration data show high vibration levels (up to 0.3 g's) at low airspeeds (for example, during landing flares) and at high airspeeds (for example, during turns). The results show that the advance ratio and the gross weight together can predict the vertical and the longitudinal vibration. However, the advance ratio and the gross weight together cannot predict the lateral vibration. The hub accelerations and the advance ratio can be used to satisfactorily predict the vertical, lateral, and longitudinal vibration. The present study shows that neural network based representations of all three UH-60A pilot floor vibration components (vertical, lateral, and longitudinal) can be obtained using the hub accelerations along with the gross weight and the advance ratio. The hub accelerations are clearly a factor in determining the pilot vibration. The present conclusions potentially allow for the identification of neural network relationships between the experimental hub accelerations obtained from wind tunnel testing and the experimental pilot vibration data obtained from flight testing. A successful establishment of the above neural network based link between the wind tunnel hub accelerations and the flight test vibration data can increase the value of wind tunnel testing.

Developing Second Language Writing through Scaffolding in the ZPD: A Magazine Project for an Authentic Audience

ERIC Educational Resources Information Center

Schwieter, John W.

2010-01-01

In the present study, Vygotsky's (1978, 1986) sociocultural framework of the zone of proximal development (ZPD) and scaffolding writing (Bodrova & Leong, 1995, 1996; Ross, 1976) are used as the theoretical basis to study the development of second language writing. A course project is presented in which advanced English language learners of Spanish…

Why Do Scholars Use Powerpoint the Way They Do?

ERIC Educational Resources Information Center

Hertz, Brigitte; van Woerkum, Cees; Kerkhof, Peter

2015-01-01

PowerPoint has received much criticism regarding excessive use of text and the lack of contact with the audience. Why presenters use PowerPoint in this way has not been studied so far. Our study using interviews with beginning and advanced presenters shows that some use the program as a speaking note and as a means to draw the attention away from…

Recommended Standards for Teacher Education. The Accreditation of Basic and Advanced Preparation Programs for Professional School Personnel.

ERIC Educational Resources Information Center

American Association of Colleges for Teacher Education, Washington, DC.

The recommended standards for teacher education presented in this booklet are the result of a 3-year study conducted by the Evaluative Criteria Study Committee of AACTE. The recommendations are presented in two major sections, one concerned with standards for basic teacher education programs (programs for the initial preparation of teachers…

A review of radiative detachment studies in tokamak advanced magnetic divertor configurations

DOE PAGES

Soukhanovskii, V. A.

2017-04-28

The present vision for a plasma–material interface in the tokamak is an axisymmetric poloidal magnetic X-point divertor. Four tasks are accomplished by the standard poloidal X-point divertor: plasma power exhaust; particle control (D/T and He pumping); reduction of impurity production (source); and impurity screening by the divertor scrape-off layer. A low-temperature, low heat flux divertor operating regime called radiative detachment is viewed as the main option that addresses these tasks for present and future tokamaks. Advanced magnetic divertor configuration has the capability to modify divertor parallel and cross-field transport, radiative and dissipative losses, and detachment front stability. Advanced magnetic divertormore » configurations are divided into four categories based on their salient qualitative features: (1) multiple standard X-point divertors; (2) divertors with higher order nulls; (3) divertors with multiple X-points; and (4) long poloidal leg divertors (and also with multiple X-points). As a result, this paper reviews experiments and modeling in the area of radiative detachment in the advanced magnetic divertor configurations.« less

A review of radiative detachment studies in tokamak advanced magnetic divertor configurations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Soukhanovskii, V. A.

The present vision for a plasma–material interface in the tokamak is an axisymmetric poloidal magnetic X-point divertor. Four tasks are accomplished by the standard poloidal X-point divertor: plasma power exhaust; particle control (D/T and He pumping); reduction of impurity production (source); and impurity screening by the divertor scrape-off layer. A low-temperature, low heat flux divertor operating regime called radiative detachment is viewed as the main option that addresses these tasks for present and future tokamaks. Advanced magnetic divertor configuration has the capability to modify divertor parallel and cross-field transport, radiative and dissipative losses, and detachment front stability. Advanced magnetic divertormore » configurations are divided into four categories based on their salient qualitative features: (1) multiple standard X-point divertors; (2) divertors with higher order nulls; (3) divertors with multiple X-points; and (4) long poloidal leg divertors (and also with multiple X-points). As a result, this paper reviews experiments and modeling in the area of radiative detachment in the advanced magnetic divertor configurations.« less

Preliminary design studies of an advanced general aviation aircraft

NASA Technical Reports Server (NTRS)

Barrett, Ron; Demoss, Shane; Dirkzwager, AB; Evans, Darryl; Gomer, Charles; Keiter, Jerry; Knipp, Darren; Seier, Glen; Smith, Steve; Wenninger, ED

1991-01-01

The preliminary design results are presented of the advanced aircraft design project. The goal was to take a revolutionary look into the design of a general aviation aircraft. Phase 1 of the project included the preliminary design of two configurations, a pusher, and a tractor. Phase 2 included the selection of only one configuration for further study. The pusher configuration was selected on the basis of performance characteristics, cabin noise, natural laminar flow, and system layouts. The design was then iterated to achieve higher levels of performance.

An example of requirements for Advanced Subsonic Civil Transport (ASCT) flight control system using structured techniques

NASA Technical Reports Server (NTRS)

Mclees, Robert E.; Cohen, Gerald C.

1991-01-01

The requirements are presented for an Advanced Subsonic Civil Transport (ASCT) flight control system generated using structured techniques. The requirements definition starts from initially performing a mission analysis to identify the high level control system requirements and functions necessary to satisfy the mission flight. The result of the study is an example set of control system requirements partially represented using a derivative of Yourdon's structured techniques. Also provided is a research focus for studying structured design methodologies and in particular design-for-validation philosophies.

NACA: University Conference on Aerodynamics. A Compilation of the Papers Presented

NASA Technical Reports Server (NTRS)

1948-01-01

This document contains reproductions of the technical papers presented at the NACA - University Conference on Aerodynamics held at the Langley Aeronautical Laboratory on June 21, 22, and 23, 1948. The conference was held in recognition of the difficulties, imposed by security restrictions, in keeping abreast of the rapid advances in aerodynamics. The papers were prepared to review the status of a number of fields of interest, to summarize the more important wartime advances that are no longer classified, and to orient reference material for further study. The papers in this document are in the same form in which they were presented at the conference so that distribution of them might be prompt. The original presentation and this record are considered as complementary to, rather than as substitutes for, the Committee?s system of complete and formal reports.

US long distance fiber optic networks: Technology, evolution and advanced concepts. Volume 3: Advanced networks and economics

NASA Technical Reports Server (NTRS)

1986-01-01

This study projects until 2000 the evolution of long distance fiber optic networks in the U.S. Volume 1 is the executive Summary. Volume 2 focuses on fiber optic components and systems that are directly related to the operation of long-haul networks. Optimistic, pessimistic and most likely scenarios of technology development are presented. The activities of national and regional companies implementing fiber long haul networks are also highlighted, along with an analysis of the market and regulatory forces affecting network evolution. Volume 3 presents advanced fiber optic network concept definitions. Inter-LATA traffic is quantified and forms the basis for the construction of 11-, 15-, 17-, and 23-node networks. Using the technology projections from Volume 2, a financial model identifies cost drivers and determines circuit mile costs between any two LATAs. A comparison of fiber optics with alternative transmission concludes the report.

US long distance fiber optic networks: Technology, evolution and advanced concepts. Volume 3: Advanced networks and economics

NASA Astrophysics Data System (ADS)

1986-10-01

This study projects until 2000 the evolution of long distance fiber optic networks in the U.S. Volume 1 is the executive Summary. Volume 2 focuses on fiber optic components and systems that are directly related to the operation of long-haul networks. Optimistic, pessimistic and most likely scenarios of technology development are presented. The activities of national and regional companies implementing fiber long haul networks are also highlighted, along with an analysis of the market and regulatory forces affecting network evolution. Volume 3 presents advanced fiber optic network concept definitions. Inter-LATA traffic is quantified and forms the basis for the construction of 11-, 15-, 17-, and 23-node networks. Using the technology projections from Volume 2, a financial model identifies cost drivers and determines circuit mile costs between any two LATAs. A comparison of fiber optics with alternative transmission concludes the report.

A Distributed Simulation Facility to Support Human Factors Research in Advanced Air Transportation Technology

NASA Technical Reports Server (NTRS)

Amonlirdviman, Keith; Farley, Todd C.; Hansman, R. John, Jr.; Ladik, John F.; Sherer, Dana Z.

1998-01-01

A distributed real-time simulation of the civil air traffic environment developed to support human factors research in advanced air transportation technology is presented. The distributed environment is based on a custom simulation architecture designed for simplicity and flexibility in human experiments. Standard Internet protocols are used to create the distributed environment, linking all advanced cockpit simulator, all Air Traffic Control simulator, and a pseudo-aircraft control and simulation management station. The pseudo-aircraft control station also functions as a scenario design tool for coordinating human factors experiments. This station incorporates a pseudo-pilot interface designed to reduce workload for human operators piloting multiple aircraft simultaneously in real time. The application of this distributed simulation facility to support a study of the effect of shared information (via air-ground datalink) on pilot/controller shared situation awareness and re-route negotiation is also presented.

Advanced Gas Turbine (AGT) powertrain system

NASA Technical Reports Server (NTRS)

Helms, H. E.; Kaufeld, J.; Kordes, R.

1981-01-01

A 74.5 kW(100 hp) advanced automotive gas turbine engine is described. A design iteration to improve the weight and production cost associated with the original concept is discussed. Major rig tests included 15 hours of compressor testing to 80% design speed and the results are presented. Approximately 150 hours of cold flow testing showed duct loss to be less than the design goal. Combustor test results are presented for initial checkout tests. Turbine design and rig fabrication is discussed. From a materials study of six methods to fabricate rotors, two have been selected for further effort. A discussion of all six methods is given.

News of Biomedical Advances in HIV: Relationship to Treatment Optimism and Expected Risk Behavior in US MSM.

PubMed

Zimmerman, Rick S; Kirschbaum, Allison L

2018-02-01

HIV treatment optimism and the ways in which news of HIV biomedical advances in HIV is presented to the most at-risk communities interact in ways that affect risk behavior and the incidence of HIV. The goal of the current study was to understand the relationships among HIV treatment optimism, knowledge of HIV biomedical advances, and current and expected increased risk behavior as a result of reading hypothetical news stories of further advances. Most of an online-recruited sample of MSM were quite knowledgeable about current biomedical advances. After reading three hypothetical news stories, 15-24% of those not living with HIV and 26-52% of those living with HIV reported their condom use would decrease if the story they read were true. Results suggest the importance of more cautious reporting on HIV biomedical advances, and for targeting individuals with greater treatment optimism and those living with HIV via organizations where they are most likely to receive their information about HIV.

Evaluation of a Terminal Area In-Trail Approach Spacing, Project and Study

NASA Technical Reports Server (NTRS)

Shelden, Stephen; Johnson, Walter (Editor)

2001-01-01

Reported here are the results of work completed as a precursor to Distributed Air Ground (DAG), Concept Element 11 (CE11) research. CE11 is a NASA, Advanced Air Transportation Technologies (AATT) concept initiated to promote research on in-trail merging and spacing during approach in the terminal area environment, such that improvements to the National Air Space (NAS) may be realized. A description of the project concept, results of a preliminary study, and a literature review are presented. In terms of conclusions, study results, and reference material respectively: 1) the concept is supported as being significant to NAS capacity improvement, 2) the preliminary study indicated that having more than one downstream, in-trail aircraft present on a CDTI during approach may be advantageous, and that flying traditional Standard Terminal Arrival Routes (STAR) utilizing advanced decision support tools (DST) may be complicated by wake turbulence considerations, a lack of vertical awareness on the part of the flight crew, and the 'step-down' nature of many terminal area approaches, and 3) the results of a literature review are presented for future reference.

Solar System Exploration Augmented by In-Situ Resource Utilization: Human Planetary Base Issues for Mercury and Saturn

NASA Technical Reports Server (NTRS)

Palaszewski, Bryan A.

2017-01-01

Human and robotic missions to Mercury and Saturn are presented and analyzed with a range of propulsion options. Historical studies of space exploration, planetary spacecraft, and astronomy, in-situ resource utilization (ISRU), and industrialization all point to the vastness of natural resources in the solar system. Advanced propulsion benefitted from these resources in many ways. While advanced propulsion systems were proposed in these historical studies, further investigation of nuclear options using high power nuclear thermal and nuclear pulse propulsion as well as advanced chemical propulsion can significantly enhance these scenarios. Updated analyses based on these historical visions are presented. Nuclear thermal propulsion and ISRU enhanced chemical propulsion landers are assessed for Mercury missions. At Saturn, nuclear pulse propulsion with alternate propellant feed systems and Saturn moon exploration with chemical propulsion and nuclear electric propulsion options are discussed. Issues with using in-situ resource utilization on Mercury missions are discussed. At Saturn, the best locations for exploration and the use of the moons Titan and Enceladus as central locations for Saturn moon exploration is assessed.

Solar System Exploration Augmented by In-Situ Resource Utilization: Mercury and Saturn Propulsion Investigations

NASA Technical Reports Server (NTRS)

Palaszewski, Bryan

2016-01-01

Human and robotic missions to Mercury and Saturn are presented and analyzed with a range of propulsion options. Historical studies of space exploration, in-situ resource utilization (ISRU), and industrialization all point to the vastness of natural resources in the solar system. Advanced propulsion benefitted from these resources in many ways. While advanced propulsion systems were proposed in these historical studies, further investigation of nuclear options using high power nuclear thermal and nuclear pulse propulsion as well as advanced chemical propulsion can significantly enhance these scenarios. Updated analyses based on these historical visions will be presented. Nuclear thermal propulsion and ISRU enhanced chemical propulsion landers are assessed for Mercury missions. At Saturn, nuclear pulse propulsion with alternate propellant feed systems and Titan exploration with chemical propulsion options are discussed. In-situ resource utilization was found to be critical in making Mercury missions more amenable for human visits. At Saturn, refueling using local atmospheric mining was found to be difficult to impractical, while refueling the Saturn missions from Uranus was more practical and less complex.

The Impact of a Multidimensional Exercise Intervention on Physical and Functional Capacity, Anxiety, and Depression in Patients With Advanced-Stage Lung Cancer Undergoing Chemotherapy.

PubMed

Quist, Morten; Adamsen, Lis; Rørth, Mikael; Laursen, Jørgen H; Christensen, Karl B; Langer, Seppo W

2015-07-01

Patients with advanced-stage lung cancer face poor survival and experience co-occurring chronic physical and psychosocial symptoms. Despite several years of research in exercise oncology, few exercise studies have targeted advanced lung cancer patients undergoing chemotherapy. The aim of the present study was to investigate the benefits of a 6-week supervised group exercise intervention and to outline the effect on aerobic capacity, strength, health-related quality of life (HRQoL), anxiety, and depression. VO2peak was assessed using an incremental exercise test. Muscle strength was measured with one repetition maximum test (1RM). HRQoL, anxiety, and depression were assessed using Functional Assessment of Cancer Therapy-Lung (FACT-L) scale and the Hospital Anxiety and Depression Scale (HADS). One hundred and forthteen patients with advanced stage lung cancer were recruited. Forty-three patients dropped out. No serious adverse events were reported. Exercise adherence in the group training was 68%. Improvements in VO2peak (P < .001) and 6-minute walk distance (P < .001) and muscle strength measurements (P < .05) were seen. There was a reduction in anxiety level (P = .0007) and improvement in the emotional well-being parameter (FACT-L) but no statistically significant changes in HRQoL were observed. The results of the present study show that during a 6-week hospital-based supervised, structured, and group-based exercise program, patients with advanced-stage lung cancer (NSCLC IIIb-IV, ED-SCLC) improve their physical capacity (VO2peak, 1RM), functional capacity, anxiety level, and emotional well-being, but not their overall HRQoL. A randomized controlled trial testing the intervention including 216 patients is currently being carried out. © The Author(s) 2015.

Is the clinicopathological pattern of colorectal carcinoma similar in the state and private healthcare systems of South Africa? Analysis of a Durban colorectal cancer database.

PubMed

Ntombela, Xolani H; Zulu, Babongile Mw; Masenya, Molikane; Sartorius, Ben; Madiba, Thandinkosi E

2017-10-01

Previous state hospital-based local studies suggest varying population-based clinicopathological patterns of colorectal cancer (CRC). Patients diagnosed with CRC in the state and private sector hospitals in Durban, South Africa over a 12-month period (January-December 2009) form the basis of our study. Of 491 patients (172 state and 319 private sector patients), 258 were men. State patients were younger than private patients. Anatomical site distribution was similar in both groups with minor variations. Stage IV disease was more common in state patients. State patients were younger, presented with advanced disease and had a lower resection rate. Black patients were the youngest, presented with advanced disease and had the lowest resection rate.

A heartrending burden of gynaecological cancers in advance stage at nuclear institute of medicine and radiotherapy Jamshoro Sindh

PubMed Central

Bibi, Seema; Ashfaque, Sanober; Laghari, Naeem Ahmed

2016-01-01

Objectives: In Pakistan gynaecological cancers are among the leading causes of women’s morbidity and mortality posing huge financial burden on families, communities and state. Due to lack of national cancer registry exact facts and figures are unknown therefore this study was planned to find out prevalence, age, site and stage of presentation of gynaecological cancers at Nuclear Institute of Medicine and Radiotherapy (NIMRA), Jamshoro. Methods: A retrospective, cross sectional study was conducted from 1st January 2011 to 31st December 2011 at NIMRA Jamshoro. All cases of genital tract cancers were evaluated, required data was entered on predesigned performa and results were analyzed manually. Results: Out of 2401 total registered cancer cases, 231 (9.6%) patients were suffering from gynaecological cancer making it third most common cancer. Ovary was commonest site followed by cervix and uterus. More than 60% cases presented in advanced stage, mostly during 4th and 5th decade of life. Conclusion: Gynecological cancer was among top three cancers at one of the busiest public sector cancer institute in Sindh province and significant number presented in advance stage making treatment difficult and expensive. There is urgent need for development and implementation of an effective health policy regarding cancer prevention and treatment. PMID:27022358

Shuttle ku-band communications/radar technical concepts

NASA Technical Reports Server (NTRS)

Griffin, J. W.; Kelley, J. S.; Steiner, A. W.; Vang, H. A.; Zrubek, W. E.; Huth, G. K.

1985-01-01

Technical data on the Shuttle Orbiter K sub u-band communications/radar system are presented. The more challenging aspects of the system design and development are emphasized. The technical problems encountered and the advancements made in solving them are discussed. The radar functions are presented first. Requirements and design/implementation approaches are discussed. Advanced features are explained, including Doppler measurement, frequency diversity, multiple pulse repetition frequencies and pulse widths, and multiple modes. The communications functions that are presented include advances made because of the requirements for multiple communications modes. Spread spectrum, quadrature phase shift keying (QPSK), variable bit rates, and other advanced techniques are discussed. Performance results and conclusions reached are outlined.

Performance estimation for highly loaded six and ten blade propellers combined with an advanced technology turboshaft engine

NASA Technical Reports Server (NTRS)

Morris, S. J., Jr.

1980-01-01

Performance estimations, weights, and scaling laws for the six blade and ten blade highly loaded propellers combined with an advanced turboshaft engine are presented. These data are useful for aircraft mission studies using the turboprop system. Comparisons are made between the performance of post 1980 technology turboprop propulsion systems and the performance of both a current technology turbofan and a post 1990 technology turbofan.

The Future of Green Aviation

NASA Technical Reports Server (NTRS)

Edwards, Thomas

2012-01-01

Dr. Edwards'presentation provides an overview of aviation's economic impact in the U.S. including aviation's impact on environment and energy. The presentation discusses NASA's contributions to the advancement of commercial aircraft design highlighting the technology drivers and recent technology advancements for addressing community noise, energy efficiency and emissions. The presentation concludes with a preview of some of NASA's integrated systems solutions, such as novel aircraft concepts and advancements in propulsion that will enable the future of more environmentally compatible aviation.

Nonlinear three-dimensional verification of the SPECYL and PIXIE3D magnetohydrodynamics codes for fusion plasmas

NASA Astrophysics Data System (ADS)

Bonfiglio, D.; Chacón, L.; Cappello, S.

2010-08-01

With the increasing impact of scientific discovery via advanced computation, there is presently a strong emphasis on ensuring the mathematical correctness of computational simulation tools. Such endeavor, termed verification, is now at the center of most serious code development efforts. In this study, we address a cross-benchmark nonlinear verification study between two three-dimensional magnetohydrodynamics (3D MHD) codes for fluid modeling of fusion plasmas, SPECYL [S. Cappello and D. Biskamp, Nucl. Fusion 36, 571 (1996)] and PIXIE3D [L. Chacón, Phys. Plasmas 15, 056103 (2008)], in their common limit of application: the simple viscoresistive cylindrical approximation. SPECYL is a serial code in cylindrical geometry that features a spectral formulation in space and a semi-implicit temporal advance, and has been used extensively to date for reversed-field pinch studies. PIXIE3D is a massively parallel code in arbitrary curvilinear geometry that features a conservative, solenoidal finite-volume discretization in space, and a fully implicit temporal advance. The present study is, in our view, a first mandatory step in assessing the potential of any numerical 3D MHD code for fluid modeling of fusion plasmas. Excellent agreement is demonstrated over a wide range of parameters for several fusion-relevant cases in both two- and three-dimensional geometries.

Nonlinear three-dimensional verification of the SPECYL and PIXIE3D magnetohydrodynamics codes for fusion plasmas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bonfiglio, Daniele; Chacon, Luis; Cappello, Susanna

2010-01-01

With the increasing impact of scientific discovery via advanced computation, there is presently a strong emphasis on ensuring the mathematical correctness of computational simulation tools. Such endeavor, termed verification, is now at the center of most serious code development efforts. In this study, we address a cross-benchmark nonlinear verification study between two three-dimensional magnetohydrodynamics (3D MHD) codes for fluid modeling of fusion plasmas, SPECYL [S. Cappello and D. Biskamp, Nucl. Fusion 36, 571 (1996)] and PIXIE3D [L. Chacon, Phys. Plasmas 15, 056103 (2008)], in their common limit of application: the simple viscoresistive cylindrical approximation. SPECYL is a serial code inmore » cylindrical geometry that features a spectral formulation in space and a semi-implicit temporal advance, and has been used extensively to date for reversed-field pinch studies. PIXIE3D is a massively parallel code in arbitrary curvilinear geometry that features a conservative, solenoidal finite-volume discretization in space, and a fully implicit temporal advance. The present study is, in our view, a first mandatory step in assessing the potential of any numerical 3D MHD code for fluid modeling of fusion plasmas. Excellent agreement is demonstrated over a wide range of parameters for several fusion-relevant cases in both two- and three-dimensional geometries.« less

Differences in presenting advance directives in the chart, in the minimum data set, and through the staff's perceptions.

PubMed

Cohen-Mansfield, Jiska; Libin, Alexander; Lipson, Steven

2003-06-01

Decisions concerning end-of-life care depend on information contained in advance directives that are documented in residents' charts in the nursing home. The availability of that information depends on the quality of the chart and on the location of the information in the chart. No research was found that compared directives by the manner in which they are collected and summarized in the chart. The goal of the proposed study was to clarify how advance directives are summarized in the patient's record and to clarify how physicians perceive the same advance directives and formal orders. The study involved 122 elderly persons who reside in one large (587 beds) nursing home. The authors collected data regarding the advance directives from three sources-Minimum Data Set (MDS), the front cover of the resident's chart, and from inside the chart. The rates of documented advance directives found in this study are higher than those reported in the literature. Agreement rates between sources varied as a function of which sources were compared, as well as on the basis of which directive was examined. More specifically, the authors found higher rates of agreement between the information inside the chart and on the cover of the chart than between the MDS and the other two sources. The reasons for discrepancies may lie in the different functions and procedures pertaining to these source documents.

Patient Preferences and Urologist Judgments on Prostate Cancer Therapy in Japan.

PubMed

Nakayama, Masahiko; Kobayashi, Hisanori; Okazaki, Masateru; Imanaka, Keiichiro; Yoshizawa, Kazutake; Mahlich, Jörg

2018-05-01

The purpose of the present study is to investigate the concordance of treatment preferences between patients and physicians in prostate cancer (PCa) in Japan. An internet-based discrete choice experiment was conducted. Patients and physicians were asked to select their preferred treatment from a pair of hypothetical treatments consisting of four attributes: quality of life (QOL), treatment effectiveness, side effects, and accessibility of treatment. The data were analyzed using a conditional logistic regression model to calculate coefficients and the relative importance (RI) of each attribute. A total of 103 PCa patients and 127 physicians responded. The study looked at 37 patients considered as advanced PCa and 66 who were non-advanced PCa. All of the physicians were urologists. Advanced PCa patients ranked the attributes as follows: treatment effectiveness (RI: 32%), accessibility of treatment (RI: 26%), QOL (RI: 23%), and side effects (RI: 19%). For physicians, the RI ranking was the same as for advanced PCa patients; treatment effectiveness (RI: 29%), accessibility of treatment (RI: 27%), QOL (RI: 26%), and side effects (RI: 18%). For non-advanced PCa patients, accessibility of treatment ranked the highest RI (27%) and treatment effectiveness ranked as the lowest RI (14%). Our study suggests that the ranking of the attributes was consistent between advanced PCa patients and physicians. The most influential attribute was treatment effectiveness. Treatment preferences also vary by disease stage.

Advanced Metering Implementations - A Perspective from Federal Sector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eaarni, Shankar

2014-08-11

Federal mandate (EPACT 2005) requires that federal buildings install advanced electrical meters-meters capable of providing data at least daily and measuring the consumption of electricity at least hourly. This work presents selected advanced metering implementations to understand some of the existing practices related to data capture and to understand how the data is being translated into information and knowledge that can be used to improve building energy and operational performance to meet federal energy reduction mandates. This study highlights case studies to represent some of the various actions that are being taken based on the data that are being collectedmore » to improve overall energy performance of these buildings. Some of these actions include- individualized tenant billing and energy forecasting, benchmarking, identifying energy conservation measures, measurement and verification.« less

Preliminary design and analysis of an advanced rotorcraft transmission

NASA Technical Reports Server (NTRS)

Henry, Z. S.

1990-01-01

Future rotorcraft transmissions of the 1990s and beyond the year 2000 require the incorporation of key emerging material and component technologies using advanced and innovative design practices in order to meet the requirements for a reduced weight-to-power ratio, a decreased noise level, and a substantially increased reliability. The specific goals for future rotocraft transmissions when compared with current state-of-the-art transmissions are a 25 percent weight reduction, a 10-dB reduction in the transmitted noise level, and a system reliability of 5000 hours mean-time-between-removal for the transmission. This paper presents the results of the design studies conducted to meet the stated goals for an advanced rotorcraft transmission. These design studies include system configuration, planetary gear train selection, and reliability prediction methods.

Effect of advanced aircraft noise reduction technology on the 1990 projected noise environment around Patrick Henry Airport. [development of noise exposure forecast contours for projected traffic volume and aircraft types

NASA Technical Reports Server (NTRS)

Cawthorn, J. M.; Brown, C. G.

1974-01-01

A study has been conducted of the future noise environment of Patric Henry Airport and its neighboring communities projected for the year 1990. An assessment was made of the impact of advanced noise reduction technologies which are currently being considered. These advanced technologies include a two-segment landing approach procedure and aircraft hardware modifications or retrofits which would add sound absorbent material in the nacelles of the engines or which would replace the present two- and three-stage fans with a single-stage fan of larger diameter. Noise Exposure Forecast (NEF) contours were computed for the baseline (nonretrofitted) aircraft for the projected traffic volume and fleet mix for the year 1990. These NEF contours are presented along with contours for a variety of retrofit options. Comparisons of the baseline with the noise reduction options are given in terms of total land area exposed to 30 and 40 NEF levels. Results are also presented of the effects on noise exposure area of the total number of daily operations.

Focus group exploration of presence through advanced broadcast services

NASA Astrophysics Data System (ADS)

Freeman, Jonathan; Avons, Steve E.

2000-06-01

Presence is a user's subjective sensation of 'being there' in a mediated environment. Its determinants include the extent of sensory information within a mediated environment, the user's ability to control their sensors and modify content within the environment, and individual-difference based factors. Although direct subjective ratings of presence have been used, the construct may be unclear to naive observers, and previous work in our laboratory has shown that ratings of presence may be biased towards different characteristics of the display. In the present study focus groups were used to: (1) establish whether viewers refer to sensations of presence, unprompted, (2) identify viewers' descriptions of their experiences of stereoscopic TV, and (3) identify the program types best suited to advanced broadcast presentations. Results showed that non-experts describe sensations of presence without prompting while watching stereoscopic television, relating it to involvement, realism and naturalness. In addition, there was a general consensus that live events, such as sports matches, theatre and concerts are the program types best suited to high-presence broadcast presentations, through advanced broadcast services such as Immersive Television.

Advanced Air Traffic Management System Study Overview

DOT National Transportation Integrated Search

1975-06-01

This report summarizes the U.S. Department of Transportation study and development plans for the air traffic management system of the late 1980's and beyond. The plans are presented in the framework of an evolutionary system concept of traffic manage...

Advanced Air Traffic Management System Study : Executive Summary

DOT National Transportation Integrated Search

1975-01-01

This report summarizes the U.S. Department of Transportation study and development plans for the air traffic management system of the late 1980's and beyond. The plans are presented in the framework of an evolutionary system concept of traffic manage...

Advanced Air Traffic Management System Study - Technical Summary

DOT National Transportation Integrated Search

1975-03-01

This report summarizes the U.S. Department of Transportation study and development plans for the air traffic management system of the late 1980's and beyond. The plans are presented in the framework of an evolutionary system concept of traffic manage...

Effects of advanced aging on the neural correlates of successful recognition memory

PubMed Central

Wang, Tracy H.; Kruggel, Frithjof; Rugg, Michael D.

2009-01-01

Functional neuroimaging studies have reported that the neural correlates of retrieval success (old>new effects) are larger and more widespread in older than in young adults. In the present study we investigated whether this pattern of age-related ‘over-recruitment’ continues into advanced age. Using functional magnetic resonance imaging (fMRI), retrieval-related activity from two groups (N = 18 per group) of older adults aged 84–96 yrs (‘old-old’) and 64–77 yrs (‘young-old’) was contrasted. Subjects studied a series of pictures, half of which were presented once, and half twice. At test, subjects indicated whether each presented picture was old or new. Recognition performance of the old-old subjects for twice-studied items was equivalent to that of the young-old subjects for once-studied items. Old>new effects common to the two groups were identified in several cortical regions, including medial and lateral parietal and prefrontal cortex. There were no regions where these effects were of greater magnitude in the old-old group, and thus no evidence of over-recruitment in this group relative to the young-old individuals. In one region of medial parietal cortex, effects were greater (and only significant) in the young-old group. The failure to find evidence of over-recruitment in the old-old subjects relative to the young-old group, despite their markedly poorer cognitive performance, suggests that age-related over-recruitment effects plateau in advanced age. The findings for the medial parietal cortex underscore the sensitivity of this cortical region to increasing age. PMID:19428399

ISAAC Advanced Composites Research Testbed

NASA Technical Reports Server (NTRS)

Wu, K. Chauncey; Stewart, Brian K.; Martin, Robert A.

2014-01-01

The NASA Langley Research Center is acquiring a state-of-art composites fabrication capability to support the Center's advanced research and technology mission. The system introduced in this paper is named ISAAC (Integrated Structural Assembly of Advanced Composites). The initial operational capability of ISAAC is automated fiber placement, built around a commercial system from Electroimpact, Inc. that consists of a multi-degree of freedom robot platform, a tool changer mechanism, and a purpose-built fiber placement end effector. Examples are presented of the advanced materials, structures, structural concepts, fabrication processes and technology development that may be enabled using the ISAAC system. The fiber placement end effector may be used directly or with appropriate modifications for these studies, or other end effectors with different capabilities may either be bought or developed with NASA's partners in industry and academia.

Tests of Full-Scale Helicopter Rotors at High Advancing Tip Mach Numbers and Advance Ratios

NASA Technical Reports Server (NTRS)

Biggers, James C.; McCloud, John L., III; Stroub, Robert H.

2015-01-01

As a continuation of the studies of reference 1, three full-scale helicopter rotors have been tested in the Ames Research Center 40- by SO-foot wind tunnel. All three of them were two-bladed, teetering rotors. One of the rotors incorporated the NACA 0012 airfoil section over the entire length of the blade. This rotor was tested at advance ratios up to 1.05. Both of the other rotors were tapered in thickness and incorporated leading-edge camber over the outer 20 percent of the blade radius. The larger of these rotors was tested at advancing tip Mach numbers up to 1.02. Data were obtained for a wide range of lift and propulsive force, and are presented without discussion.

Advanced Motor Drives Studies

NASA Technical Reports Server (NTRS)

Ehsani, M.; Tchamdjou, A.

1997-01-01

This report presents an evaluation of advanced motor drive systems as a replacement for the hydrazine fueled APU units. The replacement technology must meet several requirements which are particular to the space applications and the Orbiter in general. Some of these requirements are high efficiency, small size, high power density. In the first part of the study several motors are compared, based on their characteristics and in light of the Orbiter requirements. The best candidate, the brushless DC is chosen because of its particularly good performance with regards to efficiency. Several power electronics drive technologies including the conventional three-phase hard switched and several soft-switched inverters are then presented. In the last part of the study, a soft-switched inverter is analyzed and compared to its conventional hard-switched counterpart. Optimal efficiency is a basic requirement for space applications and the soft-switched technology represents an unavoidable trend for the future.

Study of metallic structural design concepts for an arrow wing supersonic cruise configuration

NASA Technical Reports Server (NTRS)

Turner, M. J.; Grande, D. L.

1977-01-01

A structural design study was made, to assess the relative merits of various metallic structural concepts and materials for an advanced supersonic aircraft cruising at Mach 2.7. Preliminary studies were made to ensure compliance of the configuration with general design criteria, integrate the propulsion system with the airframe, select structural concepts and materials, and define an efficient structural arrangement. An advanced computerized structural design system was used, in conjunction with a relatively large, complex finite element model, for detailed analysis and sizing of structural members to satisfy strength and flutter criteria. A baseline aircraft design was developed for assessment of current technology. Criteria, analysis methods, and results are presented. The effect on design methods of using the computerized structural design system was appraised, and recommendations are presented concerning further development of design tools, development of materials and structural concepts, and research on basic technology.

Examining trust in health professionals among family caregivers of nursing home residents with advanced dementia.

PubMed

Boogaard, Jannie A; Werner, Perla; Zisberg, Anna; van der Steen, Jenny T

2017-12-01

In a context of increasing emphasis on shared decision-making and palliative care in dementia, research on family caregivers' trust in health professionals in advanced dementia is surprisingly scant. The aim of the present study was to assess trust in nursing home health professionals of family caregivers of nursing home residents with advanced dementia, and possible correlates, such as family caregivers' satisfaction, involvement in care, care burden and patients' symptom burden. A cross-sectional study was carried out using structured questionnaires administered through the telephone. Generalized estimating equation analyses with adjustment for nursing home clustering were applied to assess the most important associations with family caregivers' trust. A total of 214 family caregivers of persons with dementia residing in 25 nursing homes participated in the study. The majority of the participants (67%) were women and adult children (75%). The majority of the family caregivers trusted physicians, nurses and nurses' aides at a moderate-to-high level. Approximately half to one-third reported moderate-to-low levels of trust. Higher levels of trust were associated with more positive care outcomes, such as higher family satisfaction with care and more positive evaluations of physician-family communication. The present study showed the importance of family caregivers trusting nursing home health professionals for their experiences as caregivers. Although causation cannot be established, increased family caregivers' trust in nursing home health professionals by improving communication and exchange of information might provide a good basis for providing optimal palliative care in advanced dementia. Geriatr Gerontol Int 2017; 17: 2466-2471. © 2017 Japan Geriatrics Society.

Surgical treatment analysis of idiopathic esophageal achalasia.

PubMed

Aquino, José Luis Braga de; Said, Marcelo Manzano; Pereira, Douglas Rizzanti; Amaral, Paula Casals do; Lima, Juliana Carolina Alves; Leandro-Merhi, Vânia Aparecida

2015-01-01

Idiopathic esophageal achalasia is an inflammatory disease of unknown origin, characterized by aperistalsis of the esophageal body and failure of the lower esophageal sphincter in response to swallowing, with consequent dysphagia. To demonstrate the results of surgical therapy in these patients, evaluating the occurred local and systemic complications. Were studied retrospectively 32 patients, 22 of whom presented non-advanced stage of the disease (Stage I/II) and 10 with advanced disease (Stage III/IV). All of them had the clinical conditions to be submitted to surgery. The diagnoses were done by clinical, endoscopic, cardiological, radiological and esophageal manometry analysis. Pre-surgical evaluation was done with a questionnaire based on the most predisposing factors in the development of the disease and the surgical indication was based on the stage of the disease. The patients with non-advanced stages were submitted to cardiomyotomy with fundoplication, wherein in the post-surgical early assessment, only one (4,4%) presented pulmonary infection, but had a good outcome. In patients with advanced disease, seven were submitted to esophageal mucosectomy preserving the muscular layer, wherein one patient (14,2%) presented dehiscence of gastric cervical esophagus anastomosis as well as pulmonary infection; all of these complications were resolved with proper specific treatment; the other three patients with advanced stage were submitted to transmediastinal esophagectomy; two of them presented hydropneumothorax with good evolution, and one of them also presented fistula of the cervical esophagogastric anastomosis, but with spontaneous healing after conservative treatment and nutritional support. The two patients with fistula of the cervical anastomosis progressed to stenosis, with good results after endoscopic dilations. In the medium and long term assessment done in 23 patients, all of them reported improvement in life quality, with return to swallowing. The strategy proposed for the surgical treatment of idiopathic esophageal achalasia according to the stages of the disease was of great value, due to post-surgical low morbidity complications and proper recovery of swallowing.

Advances in the Study of the Middle Cranial Fossa through Cutting Edge Neuroimaging Techniques.

PubMed

Juanes Méndez, Juan A; Ruisoto, Pablo; Paniagua, Juan C; Prats, Alberto

2018-01-16

The objective of this paper is to present a morphometric study of the middle cranial fossa from the study of 87 patients using cutting edge multislice computed tomography scans (32 detectors) and Magnetic Resonance Imaging. The study presents a detailed anatomical-radiological and morphometric analysis of the middle cranial fossa as well as its neurovascular elements in normal conditions. The implications of this investigation in training and clinical contexts are discussed.

Natural course and predictors of severe disability and death in Thai patients with dementia.

PubMed

Dharmasaroja, Pornpatr A; Lolekha, Praween; Kulkantrakorn, Kongkiat; Charernboon, Thammanard; Watcharakorn, Arvemas; Piyabhan, Pritsana

2017-12-01

More than half of patients with dementia lived in countries with low and middle incomes. However, there have been few studies on the natural course of disease in these countries. The purpose of this study was to study the natural course and the predictive factors of advanced stage and death in Thai patients with dementia. Patients with dementia who were treated in neurologic and psychiatric clinic from September 2004 to February 2016, were included. Data about natural course of diseases, behavioral and psychological symptoms in dementia (BPSD) and complications were studied. 207 patients were included. Mean age was 77years old. Mean Thai Mental State Examination (TMSE) was 17.5. Alzheimer's disease was the most common cause of dementia (55%). With the mean follow-up of 39months (range from 2 to 126months), 64% of the patients had BPSD. Sixty-two patients (30%) had complications required admission. Seven patients died. Fifty-four patients (29%) ended in the advanced stage of dementia. Mean duration from diagnosis to the advanced stage was 49months. Complications that required admission usually occurred in moderate to severe dementia and were strongly associated with the advanced stage or death (OR 6.1, 95%CI 2.57-14.49, p-value<0.0001). Alzheimer's disease was the most common cause of dementia in the study. Most demented patients presented in moderate severity of dementia. Mean duration from diagnosis to the advanced stage of dementia was approximate 4-5years. Complications required admissions related to the progression to advanced stage or death. Copyright © 2017 Elsevier Ltd. All rights reserved.

WAATS: A computer program for Weights Analysis of Advanced Transportation Systems

NASA Technical Reports Server (NTRS)

Glatt, C. R.

1974-01-01

A historical weight estimating technique for advanced transportation systems is presented. The classical approach to weight estimation is discussed and sufficient data is presented to estimate weights for a large spectrum of flight vehicles including horizontal and vertical takeoff aircraft, boosters and reentry vehicles. A computer program, WAATS (Weights Analysis for Advanced Transportation Systems) embracing the techniques discussed has been written and user instructions are presented. The program was developed for use in the ODIN (Optimal Design Integration System) system.

Preliminary noise tradeoff study of a Mach 2.7 cruise aircraft

NASA Technical Reports Server (NTRS)

Mascitti, V. R.; Maglieri, D. J. (Editor); Raney, J. P. (Editor)

1979-01-01

NASA computer codes in the areas of preliminary sizing and enroute performance, takeoff and landing performance, aircraft noise prediction, and economics were used in a preliminary noise tradeoff study for a Mach 2.7 design supersonic cruise concept. Aerodynamic configuration data were based on wind-tunnel model tests and related analyses. Aircraft structural characteristics and weight were based on advanced structural design methodologies, assuming conventional titanium technology. The most advanced noise prediction techniques available were used, and aircraft operating costs were estimated using accepted industry methods. The 4-engines cycles included in the study were based on assumed 1985 technology levels. Propulsion data was provided by aircraft manufacturers. Additional empirical data is needed to define both noise reduction features and other operating characteristics of all engine cycles under study. Data on VCE design parameters, coannular nozzle inverted flow noise reduction and advanced mechanical suppressors are urgently needed to reduce the present uncertainties in studies of this type.

The Human Domain and the Future of Army Warfare: Present as Prelude to 2050

DTIC Science & Technology

2017-07-01

ERDC/CERL MP-17-2 ii Abstract Studies on the future of warfare tend to focus on technology and place but largely overlook the actors. Warfare in 2050...will be predominantly urban, utilizing robotics and other advanced technologies , but at the core will re- main an inherently human and political...collaboration for success. Despite the ap- peal of advanced technology , the U.S. Army could greatly benefit by looking beyond strictly technological

Cogeneration Technology Alternatives Study (CTAS). Volume 3: Energy conversion system characteristics

NASA Technical Reports Server (NTRS)

1980-01-01

Six current and thirty-six advanced energy conversion systems were defined and combined with appropriate balance of plant equipment. Twenty-six industrial processes were selected from among the high energy consuming industries to serve as a frame work for the study. Each conversion system was analyzed as a cogenerator with each industrial plant. Fuel consumption, costs, and environmental intrusion were evaluated and compared to corresponding traditional values. The advanced energy conversion technologies indicated reduced fuel consumption, costs, and emissions. Fuel energy savings of 10 to 25 percent were predicted compared to traditional on site furnaces and utility electricity. With the variety of industrial requirements, each advanced technology had attractive applications. Fuel cells indicated the greatest fuel energy savings and emission reductions. Gas turbines and combined cycles indicated high overall annual savings. Steam turbines and gas turbines produced high estimated returns. In some applications, diesels were most efficient. The advanced technologies used coal derived fuels, or coal with advanced fluid bed combustion or on site gasifications. Data and information for both current and advanced energy conversion technology are presented. Schematic and physical descriptions, performance data, equipment cost estimates, and predicted emissions are included. Technical developments which are needed to achieve commercialization in the 1985-2000 period are identified.

Student perceptions about the mission of dental schools to advance global dentistry and philanthropy.

PubMed

Ivanoff, Chris S; Ivanoff, Athena E; Yaneva, Krassimira; Hottel, Timothy L; Proctor, Hannah L

2013-10-01

In this study, 491 dental students at one dental school in the United States and one in Bulgaria were surveyed to assess their perceptions about the mission of dental schools to advance global dentistry and philanthropy. The study included questions about prior involvement in charitable dental missions. Many respondents felt that their dental school does not advance global dentistry nor adequately teaches students the virtues of philanthropy and volunteerism. The majority agreed, however, that dental schools have a moral obligation to raise the level of oral health care worldwide and help underserved communities access basic dental care. They reported that an opportunity to spend a semester at a foreign dental school would enhance their dental education in ways that are not presently fulfilled; help them better understand cultural diversity; and teach them about philanthropy and volunteerism. In their opinion, international exchange programs that provide clinical rotations and field experiences in economically challenged and underserved areas of the world would a) foster the global advancement of dentistry; b) promote an appreciation for cultural diversity and socioeconomic disparity in the communities that graduates will be serving; and c) teach students the virtues of philanthropy and volunteerism. This study may contribute to understanding factors affecting student involvement in programs to advance global dentistry.

IDEAS: A multidisciplinary computer-aided conceptual design system for spacecraft

NASA Technical Reports Server (NTRS)

Ferebee, M. J., Jr.

1984-01-01

During the conceptual development of advanced aerospace vehicles, many compromises must be considered to balance economy and performance of the total system. Subsystem tradeoffs may need to be made in order to satisfy system-sensitive attributes. Due to the increasingly complex nature of aerospace systems, these trade studies have become more difficult and time-consuming to complete and involve interactions of ever-larger numbers of subsystems, components, and performance parameters. The current advances of computer-aided synthesis, modeling and analysis techniques have greatly helped in the evaluation of competing design concepts. Langley Research Center's Space Systems Division is currently engaged in trade studies for a variety of systems which include advanced ground-launched space transportation systems, space-based orbital transfer vehicles, large space antenna concepts and space stations. The need for engineering analysis tools to aid in the rapid synthesis and evaluation of spacecraft has led to the development of the Interactive Design and Evaluation of Advanced Spacecraft (IDEAS) computer-aided design system. The ADEAS system has been used to perform trade studies of competing technologies and requirements in order to pinpoint possible beneficial areas for research and development. IDEAS is presented as a multidisciplinary tool for the analysis of advanced space systems. Capabilities range from model generation and structural and thermal analysis to subsystem synthesis and performance analysis.

Development of ADOCS controllers and control laws. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

Landis, Kenneth H.; Glusman, Steven I.

1985-01-01

The Advanced Cockpit Controls/Advanced Flight Control System (ACC/AFCS) study was conducted by the Boeing Vertol Company as part of the Army's Advanced Digital/Optical Control System (ADOCS) program. Specifically, the ACC/AFCS investigation was aimed at developing the flight control laws for the ADOCS demonstrator aircraft that will provide satisfactory handling qualities for an attack helicopter mission. The three major elements of design considered during the study are as follows: Pilot's integrated Side-Stick Controller (SSC) -- Number of axes controlled; force/displacement characteristics; ergonomic design. Stability and Control Augmentation System (SCAS)--Digital flight control laws for the various mission phases; SCAS mode switching logic. Pilot's Displays--For night/adverse weather conditions, the dynamics of the superimposed symbology presented to the pilot in a format similar to the Advanced Attack Helicopter (AAH) Pilot Night Vision System (PNVS) for each mission phase as a function of SCAS characteristics; display mode switching logic. Volume 1 is an Executive Summary of the study. Conclusions drawn from analysis of pilot rating data and commentary were used to formulate recommendations for the ADOCS demonstrator flight control system design. The ACC/AFCS simulation data also provide an extensive data base to aid the development of advanced flight control system design for future V/STOL aircraft.

Hybrid Wing-Body (HWB) Pressurized Fuselage Modeling, Analysis, and Design for Weight Reduction

NASA Technical Reports Server (NTRS)

Mukhopadhyay, Vivek

2012-01-01

This paper describes the interim progress for an in-house study that is directed toward innovative structural analysis and design of next-generation advanced aircraft concepts, such as the Hybrid Wing-Body (HWB) and the Advanced Mobility Concept-X flight vehicles, for structural weight reduction and associated performance enhancement. Unlike the conventional, skin-stringer-frame construction for a cylindrical fuselage, the box-type pressurized fuselage panels in the HWB undergo significant deformation of the outer aerodynamic surfaces, which must be minimized without significant structural weight penalty. Simple beam and orthotropic plate theory is first considered for sizing, analytical verification, and possible equivalent-plate analysis with appropriate simplification. By designing advanced composite stiffened-shell configurations, significant weight reduction may be possible compared with the sandwich and ribbed-shell structural concepts that have been studied previously. The study involves independent analysis of the advanced composite structural concepts that are presently being developed by The Boeing Company for pressurized HWB flight vehicles. High-fidelity parametric finite-element models of test coupons, panels, and multibay fuselage sections, were developed for conducting design studies and identifying critical areas of potential failure. Interim results are discussed to assess the overall weight/strength advantages.

Presentation Trainer: What Experts and Computers Can Tell about Your Nonverbal Communication

ERIC Educational Resources Information Center

Schneider, J.; Börner, D.; van Rosmalen, P.; Specht, M.

2017-01-01

The ability to present effectively is essential for professionals; therefore, oral communication courses have become part of the curricula for higher education studies. However, speaking in public is still a challenge for many graduates. To tackle this problem, driven by the recent advances in computer vision techniques and prosody analysis,…

Advanced Terrain Displays for Transport Category Aircraft

DOT National Transportation Integrated Search

1992-02-01

A preliminary evaluation of terrain information presentation methods was conducted in a part-task simulation study. Pilots qualified on autoflight aircraft used both paper and prototypical electronic instrument approach plate formats to obtain terrai...

The Telecommunications and Data Aquisition Report

NASA Technical Reports Server (NTRS)

Posner, E. C. (Editor)

1983-01-01

Tracking and ground-based navigation techniques are discussed in relation to DSN advanced systems. Network data processing and productivity are studied to improve management planning methods. Project activities for upgrading DSN facilities are presented.

Experimental study of PAM-4, CAP-16, and DMT for 100 Gb/s short reach optical transmission systems.

PubMed

Zhong, Kangping; Zhou, Xian; Gui, Tao; Tao, Li; Gao, Yuliang; Chen, Wei; Man, Jiangwei; Zeng, Li; Lau, Alan Pak Tao; Lu, Chao

2015-01-26

Advanced modulation formats combined with digital signal processing and direct detection is a promising way to realize high capacity, low cost and power efficient short reach optical transmission system. In this paper, we present a detailed investigation on the performance of three advanced modulation formats for 100 Gb/s short reach transmission system. They are PAM-4, CAP-16 and DMT. The detailed digital signal processing required for each modulation format is presented. Comprehensive simulations are carried out to evaluate the performance of each modulation format in terms of received optical power, transmitter bandwidth, relative intensity noise and thermal noise. The performance of each modulation format is also experimentally studied. To the best of our knowledge, we report the first demonstration of a 112 Gb/s transmission over 10km of SSMF employing single band CAP-16 with EML. Finally, a comparison of computational complexity of DSP for the three formats is presented.

Acoustic emission studies of large advanced composite rocket motor cases.

NASA Technical Reports Server (NTRS)

Robinson, E. Y.

1973-01-01

Acoustic emission (AE) patterns were measured during pressure testing of advanced composite rocket motor cases made of boron/epoxy and graphite/epoxy. Both accelerometers and high frequency AE transducers were used, and both frequency spectrum and amplitude distribution were studied. The AE patterns suggest that precursor emission might be used in certain cases to anticipate failure. The technique of hold-cycle AE monitoring was also evaluated and could become a valuable decision gate for test continuation/termination. Data presented show similarity of accelerometers and AE transducer responses despite the different frequency response, and suggest that structural AE phenomena are broadband.

Geometric morphometrics and virtual anthropology: advances in human evolutionary studies.

PubMed

Rein, Thomas R; Harvati, Katerina

2014-01-01

Geometric morphometric methods have been increasingly used in paleoanthropology in the last two decades, lending greater power to the analysis and interpretation of the human fossil record. More recently the advent of the wide use of computed tomography and surface scanning, implemented in combination with geometric morphometrics (GM), characterizes a new approach, termed Virtual Anthropology (VA). These methodological advances have led to a number of developments in human evolutionary studies. We present some recent examples of GM and VA related research in human evolution with an emphasis on work conducted at the University of Tübingen and other German research institutions.

Advanced detectors and signal processing

NASA Technical Reports Server (NTRS)

Greve, D. W.; Rasky, P. H. L.; Kryder, M. H.

1986-01-01

Continued progress is reported toward development of a silicon on garnet technology which would allow fabrication of advanced detection and signal processing circuits on bubble memories. The first integrated detectors and propagation patterns have been designed and incorporated on a new mask set. In addition, annealing studies on spacer layers are performed. Based on those studies, a new double layer spacer is proposed which should reduce contamination of the silicon originating in the substrate. Finally, the magnetic sensitivity of uncontaminated detectors from the last lot of wafers is measured. The measured sensitivity is lower than anticipated but still higher than present magnetoresistive detectors.

Residential Customer Enrollment in Time-based Rate and Enabling Technology Programs: Smart Grid Investment Grant Consumer Behavior Study Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Todd, Annika; Cappers, Peter; Goldman, Charles

2013-05-01

The U.S. Department of Energy’s (DOE’s) Smart Grid Investment Grant (SGIG) program is working with a subset of the 99 SGIG projects undertaking Consumer Behavior Studies (CBS), which examine the response of mass market consumers (i.e., residential and small commercial customers) to time-varying electricity prices (referred to herein as time-based rate programs) in conjunction with the deployment of advanced metering infrastructure (AMI) and associated technologies. The effort presents an opportunity to advance the electric industry’s understanding of consumer behavior.

Advanced control design for hybrid turboelectric vehicle

NASA Technical Reports Server (NTRS)

Abban, Joseph; Norvell, Johnesta; Momoh, James A.

1995-01-01

The new environment standards are a challenge and opportunity for industry and government who manufacture and operate urban mass transient vehicles. A research investigation to provide control scheme for efficient power management of the vehicle is in progress. Different design requirements using functional analysis and trade studies of alternate power sources and controls have been performed. The design issues include portability, weight and emission/fuel efficiency of induction motor, permanent magnet and battery. A strategic design scheme to manage power requirements using advanced control systems is presented. It exploits fuzzy logic, technology and rule based decision support scheme. The benefits of our study will enhance the economic and technical feasibility of technological needs to provide low emission/fuel efficient urban mass transit bus. The design team includes undergraduate researchers in our department. Sample results using NASA HTEV simulation tool are presented.

Study of mould design and forming process on advanced polymer-matrix composite complex structure

NASA Astrophysics Data System (ADS)

Li, S. J.; Zhan, L. H.; Bai, H. M.; Chen, X. P.; Zhou, Y. Q.

2015-07-01

Advanced carbon fibre-reinforced polymer-matrix composites are widely applied to aviation manufacturing field due to their outstanding performance. In this paper, the mould design and forming process of the complex composite structure were discussed in detail using the hat stiffened structure as an example. The key issues of the moulddesign were analyzed, and the corresponding solutions were also presented. The crucial control points of the forming process such as the determination of materials and stacking sequence, the temperature and pressure route of the co-curing process were introduced. In order to guarantee the forming quality of the composite hat stiffened structure, a mathematical model about the aperture of rubber mandrel was introduced. The study presented in this paper may provide some actual references for the design and manufacture of the important complex composite structures.

STAGS Developments for Residual Strength Analysis Methods for Metallic Fuselage Structures

NASA Technical Reports Server (NTRS)

Young, Richard D.; Rose, Cheryl A.

2014-01-01

A summary of advances in the Structural Analysis of General Shells (STAGS) finite element code for the residual strength analysis of metallic fuselage structures, that were realized through collaboration between the structures group at NASA Langley, and Dr. Charles Rankin is presented. The majority of the advancements described were made in the 1990's under the NASA Airframe Structural Integrity Program (NASIP). Example results from studies that were conducted using the STAGS code to develop improved understanding of the nonlinear response of cracked fuselage structures subjected to combined loads are presented. An integrated residual strength analysis methodology for metallic structure that models crack growth to predict the effect of cracks on structural integrity is demonstrated

Candidate CDTI procedures study

NASA Technical Reports Server (NTRS)

Ace, R. E.

1981-01-01

A concept with potential for increasing airspace capacity by involving the pilot in the separation control loop is discussed. Some candidate options are presented. Both enroute and terminal area procedures are considered and, in many cases, a technologically advanced Air Traffic Control structure is assumed. Minimum display characteristics recommended for each of the described procedures are presented. Recommended sequencing of the operational testing of each of the candidate procedures is presented.

Advanced Technologies for Heterodyne Radio Astronomy Instrumentation - Part1 By A. Pavolotsky, and Advanced Technologies for Heterodyne Radio Astronomy Instrumentation - Part2 By V. Desmaris

NASA Astrophysics Data System (ADS)

Desmaris, Vincent

2018-01-01

We present the advanced micro/nano technological engineering at the atomic level producing state-of-the-art epitaxial NbN thin-films on GaN buffer layers. Furthermore, we report the outstanding performance of the hot electron bolometers fabricated on epitaxial NbN thin films on GaN buffer layers. Finally we present advanced passive devices such as waveguide hybrids, IF hybrids and combiners for the realization of heterodyne THz receivers.

Energy Conversion Alternatives Study (ECAS), General Electric Phase 1. Volume 3: Energy conversion subsystems and components. Part 1: Bottoming cycles and materials of construction

NASA Technical Reports Server (NTRS)

Shah, R. P.; Solomon, H. D.

1976-01-01

Energy conversion subsystems and components were evaluated in terms of advanced energy conversion systems. Results of the bottoming cycles and materials of construction studies are presented and discussed.

Orbit Transfer Vehicle (OTV) advanced expander cycle engine point design study. Volume 3: Engine data summary

NASA Technical Reports Server (NTRS)

1981-01-01

The engine operating characteristics were examined. Inlet pressure effects, tank pressurization effects, steady-state specific impulse, and the steady-state cycle were studied. The propellant flow schematic and operating sequence are presented. Engine hardware drawings are included.

JPL Large Advanced Antenna Station Array Study

NASA Technical Reports Server (NTRS)

1978-01-01

In accordance with study requirements, two antennas are described: a 30 meter standard antenna and a 34 meter modified antenna, along with a candidate array configuration for each. Modified antenna trade analyses are summarized, risks analyzed, costs presented, and a final antenna array configuration recommendation made.

Advanced Technology Spark-Ignition Aircraft Piston Engine Design Study

NASA Technical Reports Server (NTRS)

Stuckas, K. J.

1980-01-01

The advanced technology, spark ignition, aircraft piston engine design study was conducted to determine the improvements that could be made by taking advantage of technology that could reasonably be expected to be made available for an engine intended for production by January 1, 1990. Two engines were proposed to account for levels of technology considered to be moderate risk and high risk. The moderate risk technology engine is a homogeneous charge engine operating on avgas and offers a 40% improvement in transportation efficiency over present designs. The high risk technology engine, with a stratified charge combustion system using kerosene-based jet fuel, projects a 65% improvement in transportation efficiency. Technology enablement program plans are proposed herein to set a timetable for the successful integration of each item of required advanced technology into the engine design.

Advances in Remote Sensing for Vegetation Dynamics and Agricultural Management

NASA Technical Reports Server (NTRS)

Tucker, Compton; Puma, Michael

2015-01-01

Spaceborne remote sensing has led to great advances in the global monitoring of vegetation. For example, the NASA Global Inventory Modeling and Mapping Studies (GIMMS) group has developed widely used datasets from the Advanced Very High Resolution Radiometer (AVHRR) sensors as well as the Moderate Resolution Imaging Spectroradiometer (MODIS) map imagery and normalized difference vegetation index datasets. These data are valuable for analyzing vegetation trends and variability at the regional and global levels. Numerous studies have investigated such trends and variability for both natural vegetation (e.g., re-greening of the Sahel, shifts in the Eurasian boreal forest, Amazonian drought sensitivity) and crops (e.g., impacts of extremes on agricultural production). Here, a critical overview is presented on recent developments and opportunities in the use of remote sensing for monitoring vegetation and crop dynamics.

Incipient fault detection study for advanced spacecraft systems

NASA Technical Reports Server (NTRS)

Milner, G. Martin; Black, Michael C.; Hovenga, J. Mike; Mcclure, Paul F.

1986-01-01

A feasibility study to investigate the application of vibration monitoring to the rotating machinery of planned NASA advanced spacecraft components is described. Factors investigated include: (1) special problems associated with small, high RPM machines; (2) application across multiple component types; (3) microgravity; (4) multiple fault types; (5) eight different analysis techniques including signature analysis, high frequency demodulation, cepstrum, clustering, amplitude analysis, and pattern recognition are compared; and (6) small sample statistical analysis is used to compare performance by computation of probability of detection and false alarm for an ensemble of repeated baseline and faulted tests. Both detection and classification performance are quantified. Vibration monitoring is shown to be an effective means of detecting the most important problem types for small, high RPM fans and pumps typical of those planned for the advanced spacecraft. A preliminary monitoring system design and implementation plan is presented.

Development of advanced entry, descent, and landing technologies for future Mars Missions

NASA Technical Reports Server (NTRS)

Chu, Cheng-Chih (Chester)

2006-01-01

Future Mars missions may need the capability to land much closer to a desired target and/or advanced methods of detecting, avoiding, or tolerating landing hazards. Therefore, technologies that enable 'pinpoint landing' (within tens of meters to 1 km of a target site) will be crucial to meet future mission requirements. As part of NASA Research Announcement, NRA 03-OSS-01, NASA solicited proposals for technology development needs of missions to be launched to Mars during or after the 2009 launch opportunity. Six technology areas were identified as of high priority including advanced entry, descent, and landing (EDL) technologies. In May 2004, 11 proposals with PIs from universities, industries, and NASA centers, were awarded in the area of advanced EDL by NASA for further study and development. This paper presents an overview of these developing technologies.

Polypyrrole/carbon nanotube supercapacitors: Technological advances and challenges

NASA Astrophysics Data System (ADS)

Afzal, Adeel; Abuilaiwi, Faraj A.; Habib, Amir; Awais, Muhammad; Waje, Samaila B.; Atieh, Muataz A.

2017-06-01

The supercapacitors are advanced electrochemical energy storage devices having characteristics such as high storage capacity, rapid delivery of charge, and long cycle life. Polypyrrole (PPy) - an electronically conducting polymer, and carbon nanotubes (CNT) with high surface area and exceptional electrical and mechanical properties are among the most frequently studied advanced electrode materials for supercapacitors. The asymmetric supercapacitors composed of PPy/CNT composite electrodes offer complementary benefits to improve the specific capacitance, energy density, and stability. This article presents an overview of the recent technological advances in PPy/CNT composite supercapacitors and their limitations. Various strategies for synthesis and fabrication of PPy/CNT composites are discussed along with the factors that influence their ultimate electrochemical performance. The drawbacks and challenges of modern PPy/CNT composite supercapacitors are also reviewed, and potential areas of concern are identified for future research and development.

Advances and perspectives in in vitro human gut fermentation modeling.

PubMed

Payne, Amanda N; Zihler, Annina; Chassard, Christophe; Lacroix, Christophe

2012-01-01

The gut microbiota is a highly specialized organ containing host-specific assemblages of microbes whereby metabolic activity directly impacts human health and disease. In vitro gut fermentation models present an unmatched opportunity of performing studies frequently challenged in humans and animals owing to ethical concerns. Multidisciplinary systems biology analyses supported by '-omics' platforms remain widely neglected in the field of in vitro gut fermentation modeling but are key to advancing the significance of these models. Model-driven experimentation using a combination of in vitro gut fermentation and in vitro human cell models represent an advanced approach in identifying complex host-microbe interactions and niches central to gut fermentation processes. The aim of this review is to highlight the advances and challenges exhibited by in vitro human gut fermentation modeling. Copyright © 2011 Elsevier Ltd. All rights reserved.

Rationale for Developing a Specimen Bank to Study the Pathogenesis of High-Grade Serous Carcinoma: A Review of the Evidence.

PubMed

Sherman, Mark E; Drapkin, Ronny I; Horowitz, Neil S; Crum, Christopher P; Friedman, Sue; Kwon, Janice S; Levine, Douglas A; Shih, Ie-Ming; Shoupe, Donna; Swisher, Elizabeth M; Walker, Joan; Trabert, Britton; Greene, Mark H; Samimi, Goli; Temkin, Sarah M; Minasian, Lori M

2016-09-01

Women with clinically detected high-grade serous carcinomas (HGSC) generally present with advanced-stage disease, which portends a poor prognosis, despite extensive surgery and intensive chemotherapy. Historically, HGSCs were presumed to arise from the ovarian surface epithelium (OSE), but the inability to identify early-stage HGSCs and their putative precursors in the ovary dimmed prospects for advancing our knowledge of the pathogenesis of these tumors and translating these findings into effective prevention strategies. Over the last decade, increased BRCA1/2 mutation testing coupled with performance of risk-reducing surgeries has enabled studies that have provided strong evidence that many, but probably not all, HGSCs among BRCA1/2 mutation carriers appear to arise from the fallopian tubes, rather than from the ovaries. This shift in our understanding of the pathogenesis of HGSCs provides an important opportunity to achieve practice changing advances; however, the scarcity of clinically annotated tissues containing early lesions, particularly among women at average risk, poses challenges to progress. Accordingly, we review studies that have kindled our evolving understanding of the pathogenesis of HGSC and present the rationale for developing an epidemiologically annotated national specimen resource to support this research. Cancer Prev Res; 9(9); 713-20. ©2016 AACR. ©2016 American Association for Cancer Research.

Audience responses to television news coverage of medical advances: The mediating role of audience emotions and identification.

PubMed

Hong, Hyehyun

2015-08-01

Exemplifying a real person in news stories has become a popular journalistic technique to describe an event or issue. With the frequent appearance of medical news reports in local television in recent years, this news presentation style is widely believed to help audiences better engage in and understand complex medical information and to influence their perceptions and judgments. In terms of television news coverage of medical advances, this study investigates how audiences respond to embedded human examples (mainly patients who experience benefits from the advances) and to overall news stories, and how such responses are related to their perception of portrayed medical advances. The experimental results indicate that news stories with a human example were more likely to intensify the audience's positive emotions than those without, which in turn influenced favorable perceptions of the described medical advance. In addition, the extent to which the audience identified with a human example (in particular, sympathy) mediated the relationship between the audience's involvement in the news story and its perception of the portrayed medical advance. © The Author(s) 2014.

Proceedings of the Eighteenth NASA Propagation Experimenters Meeting (NAPEX 18) and the Advanced Communications Technology Satellite (ACTS) Propagation Studies Miniworkshop

NASA Technical Reports Server (NTRS)

Davarian, Faramaz (Editor)

1994-01-01

The NASA Propagation Experimenters Meeting (NAPEX), supported by the NASA Propagation Program, is convened annually to discuss studies made on radio wave propagation by investigators from domestic and international organizations. Participants included representatives from Canada, the Netherlands, England, and the United States, including researchers from universities, government agencies, and private industry. The meeting was organized into two technical sessions. The first session was dedicated to slant path propagation studies and experiments. The second session focused on propagation studies for mobile, personal, and sound broadcast systems. In total, 14 technical papers and some informal contributions were presented. Preceding NAPEX_17, the Advanced Communications Technology Satellite (ACTS) Propagation Studies Miniworkshop was held to review ACTS propagation activities.

[Cardiac rehabilitation. Recent advances].

PubMed

Lellamo, Ferdinando; Volterrani, Maurizio

2010-03-01

Evidence derived from studies which support the relevance of exercise as a core component of cardiac rehabilitation programs are presented, along with the beneficial effects of exercise training in counteracting the mechanisms sustaining the atherosclerotic process and cardiovascular risk factors in the context of secundary, as well as primary, cardiovascular prevention. Practical guides to plan exercise training programs are also provided with suggestions for specific pathological conditions and advanced age. Recent advances on the benefits of exercise training in patients with heart failure are reported along with the potential of telemedicine for home rehabilitation aiming to a widespread diffusion of exercise as a cardiovascular therapy. Finally, the possible risks of exercise and practical open questions in cardiac rehabilitation are discussed.

Recent advances in research on Crimean-Congo hemorrhagic fever

PubMed Central

Papa, Anna; Mirazimi, Ali; Köksal, Iftihar; Estrada-Pena, Augustin; Feldmann, Heinz

2014-01-01

Crimean-Congo hemorrhagic fever (CCHF) is an expanding tick-borne hemorrhagic disease with increasing human and animal health impact. Immense knowledge was gained over the past 10 years mainly due to advances in molecular biology, but also driven by an increased global interest in CCHFV as an emerging/re-emerging zoonotic pathogen. In the present article we discuss the advances in research with focus on CCHF ecology, epidemiology, pathogenesis, diagnostics, prophylaxis and treatment. Despite tremendous achievements, future activities have to concentrate on the development of vaccines and antivirals/therapeutics to combat CCHF. Vector studies need to continue for better public and animal health preparedness and response. We conclude with a roadmap for future research priorities. PMID:25453328

Performance of children and adolescents with Asperger syndrome or high-functioning autism on advanced theory of mind tasks.

PubMed

Kaland, Nils; Callesen, Kirsten; Møller-Nielsen, Annette; Mortensen, Erik Lykke; Smith, Lars

2008-07-01

Although a number of advanced theory of mind tasks have been developed, there is a dearth of information on whether performances on different tasks are associated. The present study examined the performance of 21 children and adolescents with diagnoses of Asperger syndrome (AS) and 20 typically developing controls on three advanced theory of mind tasks: The Eyes Task, the Strange Stories, and the Stories from Everyday Life. The participants in the clinical group demonstrated lower performance than the controls on all the three tasks. The pattern of findings, however, indicates that these tasks may share different information-processing requirements in addition to tapping different mentalizing abilities.

High rates of advanced gastric cancer in community of Flushing, New York.

PubMed

Dinani, Amreen; Desai, Amit; Kohn, Nina; Gutkin, Ellen; Nussbaum, Michel; Somnay, Kaumudi

2012-03-01

Gastric cancer remains a major public health issue and is a leading cause of death worldwide, accounting for 600,000 deaths annually. Over the last decades, there has been a steady decline in the incidence rates of gastric cancer. Furthermore, the incidence rates of gastric cancer in different parts of the country vary due to epidemiological and migration trends. Despite these trends, several studies that have continued to observe high rates of gastric cancer in populations that come from high-risk regions. The aim of the study was to describe the gastric cancer patients presenting NYHQ with an emphasis on those presenting at a young age and advanced disease. A subanalysis of the Asian population was also done, which is considered a high-risk group. Consecutive chart review of patients admitted with gastric cancer from January 2000 to August 2008 was extracted from the Oncology registry at NYHQ. Parameters that were evaluated were age, sex, race, type of gastric cancer, and stage of gastric cancer at initial presentation. The SAS/PC software package (SAS Institute Inc., Cary, NC) was employed for statistical analyses. Four hundred fifty-seven patients were diagnosed with gastric cancer. Approximately one third of the total patients were younger than 60 years of age. Of the Asian patients, almost half the patients (48.8%) had advanced disease of which two thirds were under the age of 60 years. The rates of advanced gastric cancer observed at NYHQ are significant and comparable to recent epidemiology literature on rates in Asian populations in Asia. Communities, like Flushing, NY, may benefit from early detection of gastric cancers, similar to those instituted in Japan and Taiwan.

Small Engine Component Technology (SECT) studies

NASA Technical Reports Server (NTRS)

Meyer, P. K.; Harbour, L.

1986-01-01

A study was conducted to identify component technology requirements for small, expendable gas turbine engines that would result in substantial improvements in performance and cost by the year 2000. A subsonic, 2600 nautical mile (4815 km) strategic cruise missile mission was selected for study. A baseline (state-of-the-art) engine and missile configuration were defined to evaluate the advanced technology engines. Two advanced technology engines were configured and evaluated using advanced component efficiencies and ceramic composite materials; a 22:1 overall pressure ratio, 3.85 bypass ratio twin-spool turbofan; and an 8:1 overall pressure, 3.66 bypass ratio, single-spool recuperated turbofan with 0.85 recuperator effectiveness. Results of mission analysis indicated a reduction in fuel burn of 38 and 47 percent compared to the baseline engine when using the advanced turbofan and recuperated turbofan, respectively. While use of either advanced engine resulted in approximately a 25 percent reduction in missile size, the unit life cycle (LCC) cost reduction of 56 percent for the advanced turbofan relative to the baseline engine gave it a decisive advantage over the recuperated turbofan with 47 percent LCC reduction. An additional range improvement of 10 percent results when using a 56 percent loaded carbon slurry fuel with either engine. These results can be realized only if significant progress is attained in the fields of solid lubricated bearings, small aerodynamic component performance, composite ceramic materials and integration of slurry fuels. A technology plan outlining prospective programs in these fields is presented.

Quantum technology past, present, future: quantum energetics (Conference Presentation)

NASA Astrophysics Data System (ADS)

Choi, Sang H.

2017-04-01

Since the development of quantum physics in the early part of the 1900s, this field of study has made remarkable contributions to our civilization. Some of these advances include lasers, light-emitting diodes (LED), sensors, spectroscopy, quantum dots, quantum gravity and quantum entanglements. In 1998, the NASA Langley Research Center established a quantum technology committee to monitor the progress in this area and initiated research to determine the potential of quantum technology for future NASA missions. The areas of interest in quantum technology at NASA included fundamental quantum-optics materials associated with quantum dots and quantum wells, device-oriented photonic crystals, smart optics, quantum conductors, quantum information and computing, teleportation theorem, and quantum energetics. A brief review of the work performed, the progress made in advancing these technologies, and the potential NASA applications of quantum technology will be presented.

Advanced transportation system studies. Technical area 2: Heavy lift launch vehicle development. Volume 2; Technical Results

NASA Technical Reports Server (NTRS)

1995-01-01

Sections 10 to 13 of the Advanced Transportation System Studies final report are included in this volume. Section 10 contains a copy of an executive summary that was prepared by Lockheed Space Operations Company (LSOC) to document their support to the TA-2 contract during the first-year period of performance of the contract, May 1992 through May 1993. LSOC participated on the TA-2 contract as part of the concurrent engineering launch system definition team, and provided outstanding heavy lift launch vehicle (HLLV) ground operations requirements and concept assessments for Lockheed Missiles and Space Company (LMSC) through an intercompany work transfer as well as providing specific HLLV ground operations assessments at the direction of NASA KSC through KSC funding that was routed to the TA-2 contract. Section 11 contains a copy of a vehicle-independent, launch system health management requirements assessment. The purpose of the assessment was to define both health management requirements and the associated interfaces between a generic advanced transportation system launch vehicle and all related elements of the entire transportation system, including the ground segment. Section 12 presents the major TA-2 presentations provided to summarize the significant results and conclusions that were developed over the course of the contract. Finally, Section 13 presents the design and assessment report on the first lunar outpost heavy lift launch vehicle.

Preliminary design and implementation of the baseline digital baseband architecture for advanced deep space transponders

NASA Technical Reports Server (NTRS)

Nguyen, T. M.; Yeh, H.-G.

1993-01-01

The baseline design and implementation of the digital baseband architecture for advanced deep space transponders is investigated and identified. Trade studies on the selection of the number of bits for the analog-to-digital converter (ADC) and optimum sampling schemes are presented. In addition, the proposed optimum sampling scheme is analyzed in detail. Descriptions of possible implementations for the digital baseband (or digital front end) and digital phase-locked loop (DPLL) for carrier tracking are also described.

Documenting helicopter operations from an energy standpoint

NASA Technical Reports Server (NTRS)

Davis, S. J.; Stepniewski, W. Z.

1974-01-01

Results are presented of a study of the relative and absolute energy consumption of helicopters, including limited comparisons with fixed-wing aircraft, and selected surface transportation vehicles. Additional comparisons were made to determine the level of reduction in energy consumption expected from the application of advanced technologies to the helicopter design and sizing process. It was found that improvements in helicopter consumption characteristics can be accomplished through the utilization of advanced technology to reduce drag, structures weight, and powerplant fuel consumption.

Residential photovoltaic power conditioning technology for grid connected applications

NASA Technical Reports Server (NTRS)

Key, T. S.; Klein, J. W.

1982-01-01

Major advances in photovoltaic (PV) Power Conditioning (PC) with respect to performance and low-cost potential have been made. Solutions have been obtained to interface and control problems related to adapting available inverter designs to the grid-connected, residential photovoltaic experiments. A description is presented to contributing research and development activities. Attention is given to aspects of residential systems experience, conceptual design studies, questions of optimum topology development, and promising advanced designs for residential PV provided by development efforts of the private sector.

Advanced glycation endproducts in diabetes and diabetic complications.

PubMed

Vlassara, Helen; Striker, Gary E

2013-12-01

This review presents insights from studies of advanced glycation end products (AGEs) in humans and mice. Although the emphasis is on the effects of exogenous AGEs and the suppression of specific host defense mechanisms, AGEs are also formed intracellularly, where they may contribute to several normal intracellular functions. It is only when the overall levels of AGEs in the extracellular and the intracellular spaces exceeds the ability of the native antioxidant (and AGE) defenses that they pose a problem. Copyright © 2013 Elsevier Inc. All rights reserved.

People’s War on the East Sea: Is Vietnam’s Theory of War Still Applicable

DTIC Science & Technology

2017-05-25

wording in the document concerning islands gave rise to competing claims for salient low tide features that are not present during high tide.148...People’s War on the East Sea: Is Vietnam’s Theory of War Still Applicable? A Monograph by MAJ Chad D. Corbin US Army School of Advanced... School of Advanced Military Studies. 10. SPONSOR/MONITOR’S ACRONYM(S) 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 12. DISTRIBUTION / AVAILABILITY

Chemical and biological treatment technologies for leather tannery chemicals and wastewaters: a review.

PubMed

Lofrano, Giusy; Meriç, Sureyya; Zengin, Gülsüm Emel; Orhon, Derin

2013-09-01

Although the leather tanning industry is known to be one of the leading economic sectors in many countries, there has been an increasing environmental concern regarding the release of various recalcitrant pollutants in tannery wastewater. It has been shown that biological processes are presently known as the most environmental friendly but inefficient for removal of recalcitrant organics and micro-pollutants in tannery wastewater. Hence emerging technologies such as advanced oxidation processes and membrane processes have been attempted as integrative to biological treatment for this sense. This paper, as the-state-of-the-art, attempts to revise the over world trends of treatment technologies and advances for pollution prevention from tannery chemicals and wastewater. It can be elucidated that according to less extent advances in wastewater minimization as well as in leather production technology and chemicals substitution, biological and chemical treatment processes have been progressively studied. However, there has not been a full scale application yet of those emerging technologies using advanced oxidation although some of them proved good achievements to remove xenobiotics present in tannery wastewater. It can be noted that advanced oxidation technologies integrated with biological processes will remain in the agenda of the decision makers and water sector to apply the best prevention solution for the future tanneries. Copyright © 2013 Elsevier B.V. All rights reserved.

Advanced air distribution: improving health and comfort while reducing energy use.

PubMed

Melikov, A K

2016-02-01

Indoor environment affects the health, comfort, and performance of building occupants. The energy used for heating, cooling, ventilating, and air conditioning of buildings is substantial. Ventilation based on total volume air distribution in spaces is not always an efficient way to provide high-quality indoor environments at the same time as low-energy consumption. Advanced air distribution, designed to supply clean air where, when, and as much as needed, makes it possible to efficiently achieve thermal comfort, control exposure to contaminants, provide high-quality air for breathing and minimizing the risk of airborne cross-infection while reducing energy use. This study justifies the need for improving the present air distribution design in occupied spaces, and in general the need for a paradigm shift from the design of collective environments to the design of individually controlled environments. The focus is on advanced air distribution in spaces, its guiding principles and its advantages and disadvantages. Examples of advanced air distribution solutions in spaces for different use, such as offices, hospital rooms, vehicle compartments, are presented. The potential of advanced air distribution, and individually controlled macro-environment in general, for achieving shared values, that is, improved health, comfort, and performance, energy saving, reduction of healthcare costs and improved well-being is demonstrated. Performance criteria are defined and further research in the field is outlined. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Managing an academic career in science: What gender differences exist and why?

NASA Astrophysics Data System (ADS)

Richards, Gayle Patrice

The present study examines the career trajectories of academic scientists during the period from 1993 to 2001 to explore gender differences in mobility. Data from the National Science Foundation's Survey of Doctorate Recipients are used to examine and compare gender differences in the odds of promotion. The effects of age, marital and family status, duration of time to complete doctorate, academic discipline, cumulative number of publications and time in the survey are considered as explanatory variables. Event history analyses are conducted for all scientists, for scientists in four major academic disciplines and for scientists in various academic ranks. While no overall gender differences were observed in the odds of promotion, several important similarities and differences were evident. Expectedly, publications had a significant and positive relationship with advancement for both women and men. The role of parent influenced promotions quite differently for women and men. Contrary to expectations based on prior research, academic women scientists who were mothers advanced at similar rates as women without children. Consistent with expectations based on traditional roles, married men and men with children generally advanced more quickly than single or childless men, respectively. Two surprising patterns emerged among subgroups of women. Marriage was associated with greater odds of advancement for women engineers and motherhood was associated with greater odds of advancement for among assistant professors. Possible explanations for these findings are presented.

Development of ADOCS controllers and control laws. Volume 3: Simulation results and recommendations

NASA Technical Reports Server (NTRS)

Landis, Kenneth H.; Glusman, Steven I.

1985-01-01

The Advanced Cockpit Controls/Advanced Flight Control System (ACC/AFCS) study was conducted by the Boeing Vertol Company as part of the Army's Advanced Digital/Optical Control System (ADOCS) program. Specifically, the ACC/AFCS investigation was aimed at developing the flight control laws for the ADOCS demonstator aircraft which will provide satisfactory handling qualities for an attack helicopter mission. The three major elements of design considered are as follows: Pilot's integrated Side-Stick Controller (SSC) -- Number of axes controlled; force/displacement characteristics; ergonomic design. Stability and Control Augmentation System (SCAS)--Digital flight control laws for the various mission phases; SCAS mode switching logic. Pilot's Displays--For night/adverse weather conditions, the dynamics of the superimposed symbology presented to the pilot in a format similar to the Advanced Attack Helicopter (AAH) Pilot Night Vision System (PNVS) for each mission phase is a function of SCAS characteristics; display mode switching logic. Results of the five piloted simulations conducted at the Boeing Vertol and NASA-Ames simulation facilities are presented in Volume 3. Conclusions drawn from analysis of pilot rating data and commentary were used to formulate recommendations for the ADOCS demonstrator flight control system design. The ACC/AFCS simulation data also provide an extensive data base to aid the development of advanced flight control system design for future V/STOL aircraft.

"Oh, yeah, I'm getting closer to god": spirituality and religiousness of family caregivers of cancer patients undergoing palliative care.

PubMed

Paiva, Bianca Sakamoto Ribeiro; Carvalho, André Lopes; Lucchetti, Giancarlo; Barroso, Eliane Marçon; Paiva, Carlos Eduardo

2015-08-01

Within the cancer palliative care setting, where both patients and family caregivers (FCs) undergo a transition from the end of curative treatment to palliative therapy, spirituality and religiousness (S/R) may be a strategy to help the patients and FCs better cope with the disease, in addition to exerting a positive impact on symptoms, particularly emotional symptoms. The present study aimed to understand how S/R influence FCs of cancer patients undergoing palliative care. This study was an exploratory and descriptive qualitative study. The qualitative approach to the data was based on Bardin's content analysis technique. The consolidated criteria for reporting qualitative research (COREQ-32) was used in the description of the results. Thirty FCs of individuals with advanced cancer undergoing palliative care were included. Analysis of the FCs' narratives indicated that the FCs considered that religiousness and faith in God or a Supreme Being provide them with the strength to cope with the suffering associated with the care of relatives with advanced cancer. Many FCs emphasized that talking about God was somehow comforting and made them feel at peace with themselves. Four categories were identified in the FCs' narratives: (1) increase in faith and closeness to God becomes stronger, (2) rethink life issues, (3) negative interference in the extrinsic religiosity, and (4) quest for religiousness to gain strength or support. A conceptual framework was developed. The results of the present study indicated that S/R are a coping strategy frequently used by FCs of individuals with advanced cancer. The perceptions of the FCs interviewed in the present study corresponded to the four distinct categories related to spirituality and religiousness.

Rectosigmoidian Involvement in Advanced-stage Ovarian Cancer – Intraoperative Decisions

PubMed Central

BACALBASA, NICOLAE; BALESCU, IRINA; DIMA, SIMONA

2017-01-01

Background/Aim: Ovarian cancer remains one of the most commonly encountered malignancies affecting women worldwide, that is unfortunately commonly diagnosed in advanced stages of the disease. In these stages, the tumoral process usually involves the surrounding viscera throughout contiguity or induces the apparition of distant metastases via peritoneal, lymphatic or hematogenous spread, multiple resections being needed in order to achieve a good control of the disease. Patients and Methods: In the present study, we present a case series of 12 patients in whom various surgical procedures on the rectosigmoidian loop were performed in order to achieve debulking surgery to no residual disease. Results: Digestive tract resections consisted of rectosigmoidian resection with left colostomy in three cases, low rectosigmoidian resections with anastomosis in eight cases and a stripping procedure of the peritoneal layer in one case. Conclusion: Due to the close proximity of the digestive and gynecological tract, advanced-stage ovarian tumors frequently involve the rectosigmoidian loop, imposing association of digestive tract surgical procedures. PMID:28882968

Rectosigmoidian Involvement in Advanced-stage Ovarian Cancer - Intraoperative Decisions.

PubMed

Bacalbasa, Nicolae; Balescu, Irina; Dima, Simona

2017-01-01

Ovarian cancer remains one of the most commonly encountered malignancies affecting women worldwide, that is unfortunately commonly diagnosed in advanced stages of the disease. In these stages, the tumoral process usually involves the surrounding viscera throughout contiguity or induces the apparition of distant metastases via peritoneal, lymphatic or hematogenous spread, multiple resections being needed in order to achieve a good control of the disease. In the present study, we present a case series of 12 patients in whom various surgical procedures on the rectosigmoidian loop were performed in order to achieve debulking surgery to no residual disease. Digestive tract resections consisted of rectosigmoidian resection with left colostomy in three cases, low rectosigmoidian resections with anastomosis in eight cases and a stripping procedure of the peritoneal layer in one case. Due to the close proximity of the digestive and gynecological tract, advanced-stage ovarian tumors frequently involve the rectosigmoidian loop, imposing association of digestive tract surgical procedures. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Advanced space optics development in freeform optics design, ceramic polishing, rapid and extreme freeform polishing

NASA Astrophysics Data System (ADS)

Geyl, R.; Leplan, H.; Ruch, E.

2017-09-01

In this paper Safran-Reosc wants to share with the space community its recent work performed in the domain of space optics. Our main topic is a study about the advantages that freeform optical surfaces can offer to advanced space optics in term of compactness or performances. We have separated smart and extreme freeform in our design exploration work. Our second topic is to answer about the immediate question following: can we manufacture and test these freeform optics? We will therefore present our freeform optics capability, report recent achievement in extreme aspheric optics polishing and introduce to the industrialisation process of large off axis optics polishing for the ESO Extremely Large Telescope primary mirror segments. Thirdly we present our R-SiC polishing layer technology for SiC material. This technique has been developed to reduce costs, risks and schedule in the manufacturing of advanced SiC optics for Vis and IR applications.

How challenges in auditory fMRI led to general advancements for the field.

PubMed

Talavage, Thomas M; Hall, Deborah A

2012-08-15

In the early years of fMRI research, the auditory neuroscience community sought to expand its knowledge of the underlying physiology of hearing, while also seeking to come to grips with the inherent acoustic disadvantages of working in the fMRI environment. Early collaborative efforts between prominent auditory research laboratories and prominent fMRI centers led to development of a number of key technical advances that have subsequently been widely used to elucidate principles of auditory neurophysiology. Perhaps the key imaging advance was the simultaneous and parallel development of strategies to use pulse sequences in which the volume acquisitions were "clustered," providing gaps in which stimuli could be presented without direct masking. Such sequences have become widespread in fMRI studies using auditory stimuli and also in a range of translational research domains. This review presents the parallel stories of the people and the auditory neurophysiology research that led to these sequences. Copyright © 2011 Elsevier Inc. All rights reserved.

Symptom clusters in advanced cancer.

PubMed

Jiménez, Ana; Madero, Rosario; Alonso, Alberto; Martínez-Marín, Virginia; Vilches, Yolanda; Martínez, Beatriz; Feliu, Marta; Díaz, Leyre; Espinosa, Enrique; Feliu, Jaime

2011-07-01

Patients with advanced cancer often experience multiple concurrent symptoms. Few studies have explored symptom clusters (SCs) in this population. The aim of the present study was to explore SCs in advanced cancer, evaluate the characteristics associated with various clusters, and determine their relationship to survival. This study included patients in the palliative care program of the Hospital Universitario La Paz from 2003 to 2005. The Edmonton Symptom Assessment System and a supplement including 13 other symptoms were used to detect symptoms. Principal component analysis was performed to determine symptom relationships and compare SCs with associated parameters. In total, 406 patients were included, 61% men and 39% women. The median age was 66.4 (range 18-95). The most common primaries were gastrointestinal (35%), lung (25%), genitourinary (8%), breast (5%), and head and neck (5%) carcinomas. The following clusters were identified: confusion (cognitive impairment, agitation, urinary incontinence), neuropsychological (anxiety, depression, and insomnia), anorexia-cachexia (anorexia, weight loss, and tiredness), and gastrointestinal (nausea and vomiting). The presence of these SCs was influenced by primary cancer site, gender, age, and performance status. Survival was related to the number of SCs present in a given patient: zero SC, 52 days; one SC, 38 days; two SCs, 23 days; and three to four SCs, 19 days; P < 0.001. Different SCs can be identified in patients with advanced cancer. These SCs are influenced by primary cancer site, gender, age, and Eastern Cooperative Oncology Group performance status, and they can have prognostic value. Copyright © 2011 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved.

Advancing automation and robotics technology for the Space Station Freedom and for the U.S. economy

NASA Technical Reports Server (NTRS)

Lum, Henry, Jr.

1992-01-01

In April 1985, as required by Public Law 98-371, the NASA Advanced Technology Advisory Committee (ATAC) reported to Congress the results of its studies on advanced automation and robotics technology for use on Space Station Freedom. This material was documented in the initial report (NASA Technical Memorandum 87566). A further requirement of the law was that ATAC follow NASA's progress in this area and report to Congress semiannually. This report is the fifteenth in a series of progress updates and covers the period between 27 Feb. - 17 Sep. 1992. The progress made by Levels 1, 2, and 3 of the Space Station Freedom in developing and applying advanced automation and robotics technology is described. Emphasis was placed upon the Space Station Freedom program responses to specific recommendations made in ATAC Progress Report 14. Assessments are presented for these and other areas as they apply to the advancement of automation and robotics technology for Space Station Freedom.

Surgical resection after TNFerade therapy for locally advanced pancreatic cancer.

PubMed

Chadha, Manpreet K; Litwin, Alan; Levea, Charles; Iyer, Renuka; Yang, Gary; Javle, Milind; Gibbs, John F

2009-09-04

Treatment of pancreatic cancer remains a major oncological challenge and survival is dismal. Most patients, present with advanced disease at diagnosis and are not candidates for curative resection. Preoperative chemoradiation may downstage and improve survival in locally advanced pancreatic cancer. This has prompted investigators to look for novel neoadjuvant therapies. Gene therapy for pancreatic cancer is a novel investigational approach that may have promise. TNFerade is a replication deficient adenovirus vector carrying the human tumor necrosis factor (TNF)-alpha gene regulated under control of a radiation-inducible gene promoter. Transfection of tumor cells with TNFerade maximizes the antitumor effect of TNF-alpha under influence of radiation leading to synergistic effects in preclinical studies. We describe a case of locally advanced unresectable pancreatic cancer treated with a novel multimodal approach utilizing gene therapy with TNFerade and concurrent chemoradiation that was followed by successful surgical resection. Neoadjuvant TNFerade based chemoradiation therapy may be a useful adjunct to treatment of locally advanced pancreatic cancer.

Schizophrenia Patient or Spiritually Advanced Personality? A Qualitative Case Analysis.

PubMed

Bhargav, Hemant; Jagannathan, Aarti; Raghuram, Nagarathna; Srinivasan, T M; Gangadhar, Bangalore N

2015-10-01

Many aspects of spiritual experience are similar in form and content to symptoms of psychosis. Both spiritually advanced people and patients suffering from psychopathology experience alterations in their sense of 'self.' Psychotic experiences originate from derangement of the personality, whereas spiritual experiences involve systematic thinning out of the selfish ego, allowing individual consciousness to merge into universal consciousness. Documented instances and case studies suggest possible confusion between the spiritually advanced and schizophrenia patients. Clinical practice contains no clear guidelines on how to distinguish them. Here we use a case presentation to help tabulate clinically useful points distinguishing spiritually advanced persons from schizophrenia patients. A 34-year-old unmarried male reported to our clinic with four main complaints: lack of sense of self since childhood; repeated thoughts questioning whether he existed or not; social withdrawal; and inability to continue in any occupation. Qualitative case analysis and discussions using descriptions from ancient texts and modern psychology led to the diagnosis of schizophrenia rather than spiritual advancement.

Recent advances in the applications of vibrational spectroscopic imaging and mapping to pharmaceutical formulations

NASA Astrophysics Data System (ADS)

Ewing, Andrew V.; Kazarian, Sergei G.

2018-05-01

Vibrational spectroscopic imaging and mapping approaches have continued in their development and applications for the analysis of pharmaceutical formulations. Obtaining spatially resolved chemical information about the distribution of different components within pharmaceutical formulations is integral for improving the understanding and quality of final drug products. This review aims to summarise some key advances of these technologies over recent years, primarily since 2010. An overview of FTIR, NIR, terahertz spectroscopic imaging and Raman mapping will be presented to give a perspective of the current state-of-the-art of these techniques for studying pharmaceutical samples. This will include their application to reveal spatial information of components that reveals molecular insight of polymorphic or structural changes, behaviour of formulations during dissolution experiments, uniformity of materials and detection of counterfeit products. Furthermore, new advancements will be presented that demonstrate the continuing novel applications of spectroscopic imaging and mapping, namely in FTIR spectroscopy, for studies of microfluidic devices. Whilst much of the recently developed work has been reported by academic groups, examples of the potential impacts of utilising these imaging and mapping technologies to support industrial applications have also been reviewed.

A Study Assessing the Potential of Negative Effects in Interdisciplinary Math–Biology Instruction

PubMed Central

Madlung, Andreas; Bremer, Martina; Himelblau, Edward; Tullis, Alexa

2011-01-01

There is increasing enthusiasm for teaching approaches that combine mathematics and biology. The call for integrating more quantitative work in biology education has led to new teaching tools that improve quantitative skills. Little is known, however, about whether increasing interdisciplinary work can lead to adverse effects, such as the development of broader but shallower skills or the possibility that math anxiety causes some students to disengage in the classroom, or, paradoxically, to focus so much on the mathematics that they lose sight of its application for the biological concepts in the center of the unit at hand. We have developed and assessed an integrative learning module and found disciplinary learning gains to be equally strong in first-year students who actively engaged in embedded quantitative calculations as in those students who were merely presented with quantitative data in the context of interpreting biological and biostatistical results. When presented to advanced biology students, our quantitative learning tool increased test performance significantly. We conclude from our study that the addition of mathematical calculations to the first year and advanced biology curricula did not hinder overall student learning, and may increase disciplinary learning and data interpretation skills in advanced students. PMID:21364099

Red Meat, Dietary Heme Iron, and Risk of Type 2 Diabetes: The Involvement of Advanced Lipoxidation Endproducts12

PubMed Central

White, Desley L.; Collinson, Avril

2013-01-01

There is growing evidence of disordered iron homeostasis in the diabetic condition, with links proposed between dietary iron intakes and both the risk of disease and the risk of complications of advanced disease. In the United States, Britain, and Canada, the largest dietary contributors of iron are cereals and cereal products and meat and meat products. This review discusses the findings of cohort studies and meta-analyses of heme iron and red meat intakes and the risk of type 2 diabetes. These suggest that processed red meat is associated with increased risk, with high intakes of red meat possibly also associated with a small increased risk. Historically, humans have relied on large quantities of heme iron and red meat in their diets, and therefore it is paradoxical that iron from meat sources should be associated with the risk of type 2 diabetes. A reason for this association may be drawn from studies of dietary advanced glycation and lipoxidation endproducts present in processed food and the mechanisms by which insulin output by pancreatic islet cells might be influenced by the protein modifications present in processed red meat. PMID:23858089

The development of the Nucleus Freedom Cochlear implant system.

PubMed

Patrick, James F; Busby, Peter A; Gibson, Peter J

2006-12-01

Cochlear Limited (Cochlear) released the fourth-generation cochlear implant system, Nucleus Freedom, in 2005. Freedom is based on 25 years of experience in cochlear implant research and development and incorporates advances in medicine, implantable materials, electronic technology, and sound coding. This article presents the development of Cochlear's implant systems, with an overview of the first 3 generations, and details of the Freedom system: the CI24RE receiver-stimulator, the Contour Advance electrode, the modular Freedom processor, the available speech coding strategies, the input processing options of Smart Sound to improve the signal before coding as electrical signals, and the programming software. Preliminary results from multicenter studies with the Freedom system are reported, demonstrating better levels of performance compared with the previous systems. The final section presents the most recent implant reliability data, with the early findings at 18 months showing improved reliability of the Freedom implant compared with the earlier Nucleus 3 System. Also reported are some of the findings of Cochlear's collaborative research programs to improve recipient outcomes. Included are studies showing the benefits from bilateral implants, electroacoustic stimulation using an ipsilateral and/or contralateral hearing aid, advanced speech coding, and streamlined speech processor programming.

Targeted therapy in advanced gastric carcinoma: the future is beginning.

PubMed

Schinzari, G; Cassano, A; Orlandi, A; Basso, M; Barone, C

2014-01-01

Gastric cancer represents one of the most common cancer worldwide. Unfortunately, the majority of patients present in advanced stage and outcome still remains poor with high mortality rate despite decreasing incidence and new diagnostic and therapeutic strategies. Although utility of classical chemotherapy agents has been widely explored, advances have been slow and the efficacy of these agents has reached a plateau of median overall survival not higher than 12 months. Therefore, researchers focused their attention on better understanding molecular biology of carcinogenesis and deeper knowledge of the cancer cell phenotype, as well on development of rationally designed drugs that would target specific molecular aberrancies in signal transduction pathways. These targets include cell surface receptors, circulating growth and angiogenic factors and other molecules involved in downstream intracellular signaling pathways, including receptor tyrosine kinases. However, therapeutic advances in gastric cancer are not so encouraging when compared to other solid organ malignancies such as breast and colorectal cancer. This article reviews the role of targeted agents in gastric cancer as single-agent therapy or in combination regimens, including their rational and emerging mechanism of action, current and emerging data. We focused our attention mainly on published phase III studies, therefore cornerstone clinical trials with trastuzumab and bevacizumab have been largely discussed. Phase III studies presented in important international meetings are also reviewed as well phase II published studies and promising new therapies investigated in preclinical or phase I studies. Today, in first-line treatment only trastuzumab has shown significantly increased survival in combination with chemotherapy, whereas ramucirumab as single agent resulted effective in progressing patients, but - despite several disappointing results - these are the proof of principle that targeting the proper molecular aberration is the best way for implementing outcome of therapy.

Is tube feeding futile in advanced dementia?

PubMed Central

Lynch, Matthew C.

2016-01-01

It is controversial whether tube feeding in people with dementia improves nutritional status or prolongs survival. Guidelines published by several professional societies cite observational studies that have shown no benefit and conclude that tube feeding in patients with advanced dementia should be avoided. However, all studies on tube feeding in dementia have major methodological flaws that invalidate their findings. The present evidence is not sufficient to justify general guidelines. Patients with advanced dementia represent a very heterogeneous group, and evidence demonstrates that some patients with dementia benefit from tube feeding. However, presently available guidelines make a single recommendation against tube feeding for all patients. Clinicians, patients, and surrogates should be aware that the guidelines and prior commentary on this topic tend both to overestimate the strength of evidence for futility and to exaggerate the burdens of tube feeding. Shared decision making requires accurate information tailored to the individual patient's particular situation, not blanket guidelines based on flawed data. Lay Summary: Many doctors believe that tube feeding does not help people with advanced dementia. Scientific studies suggest that people with dementia who have feeding tubes do not live longer or gain weight compared with those who are carefully hand fed. However, these studies are not very helpful because of flaws in design, which are discussed in this article. Guidelines from professional societies make a blanket recommendation against feeding tubes for anyone with dementia, but an individual approach that takes each person's situation into account seems more appropriate. Patients and surrogates should be aware that the guidelines on this topic tend both to underestimate the benefit and exaggerate the burdens of tube feeding. PMID:27833208

Intestinal obstruction management in patients with advanced abdominal neoplasia.

PubMed

Simion, L; Straja, Nd; Alecu, M; Poroch, V; Moşoiu, D; Panti, C; Grigorean, V; Brătucu, E

2014-01-01

The present study describes the difficulties encountered in the diagnostic process and treatment of intestinal obstruction developed by patients with advanced abdominal neoplasia. This unicentric and retrospective study evaluates patients suffering from intestinal occlusion operated on at the First Surgical Clinic of the Oncology Institute in Bucharest, over a period of 4 years (2010 - 2013). Of these, 61 cases in which the occlusion occurred on the background of an advanced abdominal neoplasia were selected. We considered as advanced those cases of abdominal cancer where curative oncologic treatment is no longer possible due to the evolution stage. The random selection of the study period, the introduction of all the patients identified with this type of pathology, as well as the concentration of advanced abdominal neoplasia at the Oncology Institute in Bucharest are the elements that allow us to state that the results of this study are representative. Particularities related to the clinical aspects of the intestinal occlusion in these patients, as well as difficulties in establishing the correct diagnosis were encountered.Surgical cure of the occlusion, with palliative aim of course,was possible in only 47 cases (representing 77.05%). A standard treatment course cannot be devised for this type of patients. Palliative care, indispensable in cases of advanced neoplastic disease, remains the sole therapeutic method available for patients with no surgical cure for the obstruction. The main objective, for the entire study lot, was to ensure an as high as possible quality of life,a factor we must bear in mind as often as possible when choosing a surgical solution. Of course, when surgical treatment can be applied, overcoming the occlusive episode prolongs these patients' life and can even allow for other courses of complementary treatment to be undertaken. Celsius.

Changes in Attitudes of P.S.S.C. Physics Students: A Second Look

ERIC Educational Resources Information Center

Gardner, P. L.

1973-01-01

Reports data which provide a partial replication of an earlier study of changes in attitudes of Physical Science Study Committee (PSSC) physics students. Data from the present research failed to support earlier findings. Several reasons for the discrepancies are advanced. (JR)

The Advanced Study of Gymnastics.

ERIC Educational Resources Information Center

Salmela, John H., Ed.

The sport of artistic gymnastics is viewed from a multidisciplinary point of view. The training, performance, and judgment of the sport undergo specialized study of interest to sport scientists, teachers, coaches, and athletes. Organized into five major sections, the book presents such themes as the psychological, physiological, biomechanical,…

The Impact of Accounting Education Research

ERIC Educational Resources Information Center

Sangster, Alan; Fogarty, Tim; Stoner, Greg; Marriott, Neil

2015-01-01

This paper presents an exploratory study into the nature and patterns of usage of accounting education research. The study adopts the most accessible metric, "Google Advanced Scholar" citations, to analyse the impact of research published in the six principal English-language accounting education journals. The analysis reveals a global…

Plasma confinement theory and transport simulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ross, D.W.

The objectives are: (1) to advance the transport studies of tokamaks, including development and maintenance of the Magnetic Fusion Energy Database, and (2) to provide theoretical interpretation, modeling and equilibrium and stability studies for TEXT-Upgrade. Recent reports, publications, and conference presentations of the Fusion Research Center are listed.

Morphological Structure in Native and Nonnative Language Processing

ERIC Educational Resources Information Center

Clahsen, Harald; Felser, Claudia; Neubauer, Kathleen; Sato, Mikako; Silva, Renita

2010-01-01

This article presents a selective overview of studies that have investigated how advanced adult second language (L2) learners process morphologically complex words. The studies reported here have used different kinds of experimental tasks (including speeded grammaticality judgments, lexical decision, and priming) to examine three domains of…

Advances in cardiovascular fluid mechanics: bench to bedside.

PubMed

Dasi, Lakshmi P; Sucosky, Philippe; de Zelicourt, Diane; Sundareswaran, Kartik; Jimenez, Jorge; Yoganathan, Ajit P

2009-04-01

This paper presents recent advances in cardiovascular fluid mechanics that define the current state of the art. These studies include complex multimodal investigations with advanced measurement and simulation techniques. We first discuss the complex flows within the total cavopulmonary connection in Fontan patients. We emphasize the quantification of energy losses by studying the importance of caval offsets as well as the differences among various Fontan surgical protocols. In our studies of the fluid mechanics of prosthetic heart valves, we reveal for the first time the full three-dimensional complexity of flow fields in the vicinity of bileaflet and trileaflet valves and the microscopic hinge flow dynamics. We also present results of these valves functioning in a patient-specific native aorta geometry. Our in vitro mitral valve studies show the complex mechanism of the native mitral valve apparatus. We demonstrate that the different components of the mitral valve have independent and synergistically complex functions that allow the valve to operate efficiently. We also show how valve mechanics change under pathological and repair conditions associated with enlarged ventricles. Finally, our ex vivo studies on the interactions between the aortic valve and its surrounding hemodynamic environment are aimed at providing insights into normal valve function and valve pathology. We describe the development of organ- and tissue-culture systems and the biological response of the tissue subjected to their respective simulated mechanical environment. The studies noted above have enhanced our understanding of the complex fluid mechanics associated with the cardiovascular system and have led to new translational technologies.

Teaching Facts of Addition to Brazilian Children with Attention-Deficit/Hyperactivity Disorder

ERIC Educational Resources Information Center

Costa, Adriana Corrêa; Rohde, Luis Augusto; Dorneles, Beatriz Vargas

2015-01-01

Storage and/or automatic retrieval of the basic facts of addition from the long-term memory seems to be impaired in children with ADHD presenting arithmetical difficulties. The present study was carried out to evaluate the effectiveness of an educational intervention model designed to teach basic facts of addition as a means of advancing from…

Using a Stance Corpus to Learn about Effective Authorial Stance-Taking: A Textlinguistic Approach

ERIC Educational Resources Information Center

Chang, Peichin

2012-01-01

Presenting a persuasive authorial stance is a major challenge for second language (L2) writers in writing academic research. Failure to present an effective authorial stance often results in poor evaluation, which compromises a writer's research potential. This study proposes a "textlinguistic" approach to advanced academic writing to complement a…

Breast cancer screening patterns among military beneficiaries: racial variations in screening eliminated in an equal-access model.

PubMed

Oseni, Tawakalitu O; Soballe, Peter W

2014-10-01

African American women present with more aggressive breast tumors and at later stages than white women. Many factors have been proposed to explain these findings, including socioeconomic status, cultural beliefs, and access to medical care. The purpose of this project was to determine if stage at presentation would be equivalent in a system providing equal access to care and if screening was equivalent. The Naval Medical Center San Diego (NMCSD) tumor registry from 2007 to 2012 was queried for this cross-sectional study. Eligible women included all those diagnosed and treated for breast cancer at NMCSD. Distribution of tumor stage (early vs. advanced) between racial groups was compared by age, treatment, and receptor status. A total of 624 women were eligible; 88 % were early stage (0-II) and 12 % presented with advanced stage (III or IV). Racial differences in distribution were significant among African American and Hispanic women for early versus advanced presentation (p = 0.011). No racial disparity was seen in screening patterns among women. In a military health system with equal access to care and standard screening recommendations, screening patterns did not vary with race but did vary with stage and active duty status. African American women present with breast cancer at later stages and with more hormone-receptor negative tumors, suggesting that biology rather than socioeconomic or access factors may be the most important determinant of stage at presentation of breast cancer for African American women.

Strategies for Promoting Autonomous Reading Motivation: A Multiple Case Study Research in Primary Education

ERIC Educational Resources Information Center

De Naeghel, Jessie; Van Keer, Hilde; Vanderlinde, Ruben

2014-01-01

It is important to reveal strategies which foster students' reading motivation in order to break through the declining trend in reading motivation throughout children's educational careers. Consequently, the present study advances an underexposed field in reading motivation research by studying and identifying the strategies of teachers excellent…

Learning through a Disciplined Curriculum Study Approach: Implications for Educational Leadership

ERIC Educational Resources Information Center

Henderson, James G.

2010-01-01

In this article, the author begins by describing an important present moment in curriculum studies. He then rethinks this moment and briefly explores the implications of this new line of thought for leadership development. At the 2007 American Association for the Advancement of Curriculum Studies' (AAACS) business meeting, Pinar (2007a) presented…

A novel monoclonal antibody targeting carboxymethyllysine, an advanced glycation end product in atherosclerosis and pancreatic cancer.

PubMed

Wendel, Ulrika; Persson, Nina; Risinger, Christian; Bengtsson, Eva; Nodin, Björn; Danielsson, Lena; Welinder, Charlotte; Nordin Fredrikson, Gunilla; Jansson, Bo; Blixt, Ola

2018-01-01

Advanced glycation end products are formed by non-enzymatic reactions between proteins and carbohydrates, causing irreversible lysine and arginine alterations that severely affect protein structure and function. The resulting modifications induce inflammation by binding to scavenger receptors. An increase in advanced glycation end products is observed in a number of diseases e.g. atherosclerosis and cancer. Since advanced glycation end products also are present in healthy individuals, their detection and quantification are of great importance for usage as potential biomarkers. Current methods for advanced glycation end product detection are though limited and solely measure total glycation. This study describes a new epitope-mapped single chain variable fragment, D1-B2, against carboxymethyllysine, produced from a phage library that was constructed from mouse immunizations. The phage library was selected against advanced glycation end product targets using a phage display platform. Characterization of its binding pattern was performed using large synthetic glycated peptide and protein libraries displayed on microarray slides. D1-B2 showed a preference for an aspartic acid, three positions N-terminally from a carboxymethyllysine residue and also bound to a broad collection of glycated proteins. Positive immunohistochemical staining of mouse atherosclerotic plaques and of a tissue microarray of human pancreatic tumors confirmed the usability of the new scFv for advanced glycation end product detection in tissues. This study demonstrates a promising methodology for high-throughput generation of epitope-mapped monoclonal antibodies against AGE.

A novel monoclonal antibody targeting carboxymethyllysine, an advanced glycation end product in atherosclerosis and pancreatic cancer

PubMed Central

Wendel, Ulrika; Persson, Nina; Risinger, Christian; Bengtsson, Eva; Nodin, Björn; Danielsson, Lena; Welinder, Charlotte; Nordin Fredrikson, Gunilla

2018-01-01

Advanced glycation end products are formed by non-enzymatic reactions between proteins and carbohydrates, causing irreversible lysine and arginine alterations that severely affect protein structure and function. The resulting modifications induce inflammation by binding to scavenger receptors. An increase in advanced glycation end products is observed in a number of diseases e.g. atherosclerosis and cancer. Since advanced glycation end products also are present in healthy individuals, their detection and quantification are of great importance for usage as potential biomarkers. Current methods for advanced glycation end product detection are though limited and solely measure total glycation. This study describes a new epitope-mapped single chain variable fragment, D1-B2, against carboxymethyllysine, produced from a phage library that was constructed from mouse immunizations. The phage library was selected against advanced glycation end product targets using a phage display platform. Characterization of its binding pattern was performed using large synthetic glycated peptide and protein libraries displayed on microarray slides. D1-B2 showed a preference for an aspartic acid, three positions N-terminally from a carboxymethyllysine residue and also bound to a broad collection of glycated proteins. Positive immunohistochemical staining of mouse atherosclerotic plaques and of a tissue microarray of human pancreatic tumors confirmed the usability of the new scFv for advanced glycation end product detection in tissues. This study demonstrates a promising methodology for high-throughput generation of epitope-mapped monoclonal antibodies against AGE. PMID:29420566

7 CFR 1786.207 - Prepayment premium.

Code of Federal Regulations, 2010 CFR

2010-01-01

... between the outstanding principal balance of the loan being refinanced and the present value of the loan... date of the loan advance; and (3)(i) The present value of 100 percent of the amount of interest for 1... amount being refinanced or prepaid was advanced, the present value of the difference between: (A) Each...

Concept for a Satellite-Based Advanced Air Traffic Management System : Volume 6. Development and Transition Plans.

DOT National Transportation Integrated Search

1974-02-01

The volume presents the plans for implementing the Satellite-Based Advanced Air Traffic Management System (SAATMS) described in Volumes II, III, and IV. Two plans are presented: an RDT&E plan and a transition plan. The RDT&E plan is presented as a se...

Advanced Education and Technology Business Plan, 2010-13. Highlights

ERIC Educational Resources Information Center

Alberta Advanced Education and Technology, 2010

2010-01-01

The Ministry of Advanced Education and Technology envisions Alberta's prosperity through innovation and lifelong learning. Advanced Education and Technology's mission is to lead the development of a knowledge-driven future through a dynamic and integrated advanced learning and innovation system. This paper presents the highlights of the business…

Criteria for Evaluating Advancement Programs.

ERIC Educational Resources Information Center

Heemann, Warren, Ed.

Criteria for evaluating college and university advancement programs are presented, based on the efforts of professional area trustees and advisory committees of the Council for Advancement and Support of Education (CASE). The criteria can be useful in three ways: as the basis of internal audits of advancement programs or program components; as the…

Assembling evidence for identifying reservoirs of infection

PubMed Central

Viana, Mafalda; Mancy, Rebecca; Biek, Roman; Cleaveland, Sarah; Cross, Paul C.; Lloyd-Smith, James O.; Haydon, Daniel T.

2014-01-01

Many pathogens persist in multihost systems, making the identification of infection reservoirs crucial for devising effective interventions. Here, we present a conceptual framework for classifying patterns of incidence and prevalence, and review recent scientific advances that allow us to study and manage reservoirs simultaneously. We argue that interventions can have a crucial role in enriching our mechanistic understanding of how reservoirs function and should be embedded as quasi-experimental studies in adaptive management frameworks. Single approaches to the study of reservoirs are unlikely to generate conclusive insights whereas the formal integration of data and methodologies, involving interventions, pathogen genetics, and contemporary surveillance techniques, promises to open up new opportunities to advance understanding of complex multihost systems. PMID:24726345

Assembling evidence for identifying reservoirs of infection

USGS Publications Warehouse

Mafalda, Viana; Rebecca, Mancy; Roman, Biek; Sarah, Cleaveland; Cross, Paul C.; James O, Lloyd-Smith; Daniel T, Haydon

2014-01-01

Many pathogens persist in multihost systems, making the identification of infection reservoirs crucial for devising effective interventions. Here, we present a conceptual framework for classifying patterns of incidence and prevalence, and review recent scientific advances that allow us to study and manage reservoirs simultaneously. We argue that interventions can have a crucial role in enriching our mechanistic understanding of how reservoirs function and should be embedded as quasi-experimental studies in adaptive management frameworks. Single approaches to the study of reservoirs are unlikely to generate conclusive insights whereas the formal integration of data and methodologies, involving interventions, pathogen genetics, and contemporary surveillance techniques, promises to open up new opportunities to advance understanding of complex multihost systems.

Clinical response to chemotherapy in locally advanced breast cancer was not associated with several polymorphisms in detoxification enzymes and DNA repair genes.

PubMed

Saadat, Mostafa; Khalili, Maryam; Nasiri, Meysam; Rajaei, Mehrdad; Omidvari, Shahpour; Saadat, Iraj

2012-03-02

The main aim of the present study was to investigate the association between several genetic polymorphisms (in glutathione S-transferase members and DNA repair genes) and clinical response to chemotherapy in locally advanced breast cancer. A sequential series of 101 patients were prospectively included in this study. Clinical assessment of treatment was accomplished by comparing initial tumor size with preoperative tumor size using revised RECIST guideline (version 1.1). Clinical response was regarded as a response or no response. There was no difference between non-responders and responders for the prevalence of genotypes of the study polymorphisms. Copyright © 2012 Elsevier Inc. All rights reserved.

A Longitudinal Investigation into L2 Learners' Cognitive Processes during Study Abroad

ERIC Educational Resources Information Center

Ren, Wei

2014-01-01

The present study longitudinally investigates the cognitive processes of advanced L2 learners engaged in a multimedia task that elicited status-equal and status-unequal refusals in English during their study abroad. Data were collected three times by retrospective verbal report from 20 Chinese learners who were studying abroad over the course of…

Pleasure Reading Behavior and Attitude of Non-Academic ESL Students: A Replication Study

ERIC Educational Resources Information Center

Ro, Eunseok; Chen, Cheng-Ling Alice

2014-01-01

The present study replicated the methods and data analysis of Crawford Camiciottoli's (2001) study on second language (L2) reading behavior of academic English-as-a-foreign-language students. Using the original study's questionnaire, we investigated 60 advanced non-academic English-as-a-second-language learners' L2 reading frequency and attitude.…

"Extremely minimally invasive": recent advances in nanotechnology research and future applications in neurosurgery.

PubMed

Mattei, Tobias A; Rehman, Azeem A

2015-01-01

The term "nanotechnology" refers to the development of materials and devices that have been designed with specific properties at the nanometer scale (10(-9) m), usually being less than 100 nm in size. Recent advances in nanotechnology have promised to enable visualization and intervention at the subcellular level, and its incorporation to future medical therapeutics is expected to bring new avenues for molecular imaging, targeted drug delivery, and personalized interventions. Although the central nervous system presents unique challenges to the implementation of new therapeutic strategies involving nanotechnology (such as the heterogeneous molecular environment of different CNS regions, the existence of multiple processing centers with different cytoarchitecture, and the presence of the blood-brain barrier), numerous studies have demonstrated that the incorporation of nanotechnology resources into the armamentarium of neurosurgery may lead to breakthrough advances in the near future. In this article, the authors present a critical review on the current 'state-of-the-art' of basic research in nanotechnology with special attention to those issues which present the greatest potential to generate major therapeutic progresses in the neurosurgical field, including nanoelectromechanical systems, nano-scaffolds for neural regeneration, sutureless anastomosis, molecular imaging, targeted drug delivery, and theranostic strategies.

Research on the exploitation of advanced composite materials to lightly loaded structures

NASA Technical Reports Server (NTRS)

Mar, J. W.

1976-01-01

The objective was to create a sailplane which could fly in weaker thermals than present day sailplanes (by being lighter) and to fly in stronger thermals than present sailplanes (by carrying more water ballast). The research was to tackle the interaction of advanced composites and the aerodynamic performance, the interaction of fabrication procedures and the advanced composites, and the interaction of advanced composites and the design process. Many pieces of the overall system were investigated but none were carried to the resolution required for engineering application. Nonetheless, interesting and useful results were obtained and are here reported.

Overview of Lightweight Structures for Rotorcraft Engines and Drivetrains

NASA Technical Reports Server (NTRS)

Roberts, Gary D.

2011-01-01

This is an overview presentation of research being performed in the Advanced Materials Task within the NASA Subsonic Rotary Wing Project. This research is focused on technology areas that address both national goals and project goals for advanced rotorcraft. Specific technology areas discussed are: (1) high temperature materials for advanced turbines in turboshaft engines; (2) polymer matrix composites for lightweight drive system components; (3) lightweight structure approaches for noise and vibration control; and (4) an advanced metal alloy for lighter weight bearings and more reliable mechanical components. An overview of the technology in each area is discussed, and recent accomplishments are presented.

Advanced Colloids Experiment (ACE-T1)

NASA Technical Reports Server (NTRS)

Meyer, William V.; Sicker, Ron; Brown, Dan; Eustace, John

2015-01-01

Increment 45 - 46 Science Symposium presentation of Advanced Colloids Experiment (ACE-T1) to RPO. The purpose of this event is for Principal Investigators to present their science objectives, testing approach, and measurement methods to agency scientists, managers, and other investigators.

Thermal Model Predictions of Advanced Stirling Radioisotope Generator Performance

NASA Technical Reports Server (NTRS)

Wang, Xiao-Yen J.; Fabanich, William Anthony; Schmitz, Paul C.

2014-01-01

This presentation describes the capabilities of three-dimensional thermal power model of advanced stirling radioisotope generator (ASRG). The performance of the ASRG is presented for different scenario, such as Venus flyby with or without the auxiliary cooling system.

Advanced Colloids Experiment (ACE-H-2)

NASA Technical Reports Server (NTRS)

Meyer, William V.; Sicker, Ron; Chmiel, Alan J.; Eustace, John; LaBarbera, Melissa

2015-01-01

Increment 43 - 44 Science Symposium presentation of Advanced Colloids Experiment (ACE-H-2) to RPO. The purpose of this event is for Principal Investigators to present their science objectives, testing approach, and measurement methods to agency scientists, managers, and other investigators.

Proceedings of the Ninth Annual Summer Conference: NASA/USRA University Advanced Aeronautics Design Program and Advanced Space Design Program

NASA Technical Reports Server (NTRS)

1993-01-01

The NASA/USRA University Advanced Design Program was established in 1984 as an attempt to add more and better design education to primarily undergraduate engineering programs. The original focus of the pilot program encompassing nine universities and five NASA centers was on space design. Two years later, the program was expanded to include aeronautics design with six universities and three NASA centers participating. This year marks the last of a three-year cycle of participation by forty-one universities, eight NASA centers, and one industry participant. The Advanced Space Design Program offers universities an opportunity to plan and design missions and hardware that would be of usc in the future as NASA enters a new era of exploration and discovery, while the Advanced Aeronautics Design Program generally offers opportunities for study of design problems closer to the present time, ranging from small, slow-speed vehicles to large, supersonic and hypersonic passenger transports. The systems approach to the design problem is emphasized in both the space and aeronautics projects. The student teams pursue the chosen problem during their senior year in a one- or two-semester capstone design course and submit a comprehensive written report at the conclusion of the project. Finally, student representatives from each of the universities summarize their work in oral presentations at the Annual Summer Conference, sponsored by one of the NASA centers and attended by the university faculty, NASA and USRA personnel and aerospace industry representatives. As the Advanced Design Program has grown in size, it has also matured in terms of the quality of the student projects. The present volume represents the student work accomplished during the 1992-1993 academic year reported at the Ninth Annual Summer Conference hosted by NASA Lyndon B. Johnson Space Center, June 14-18, 1993.

Analytical Study on Thermal and Mechanical Design of Printed Circuit Heat Exchanger

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yoon, Su-Jong; Sabharwall, Piyush; Kim, Eung-Soo

2013-09-01

The analytical methodologies for the thermal design, mechanical design and cost estimation of printed circuit heat exchanger are presented in this study. In this study, three flow arrangements of parallel flow, countercurrent flow and crossflow are taken into account. For each flow arrangement, the analytical solution of temperature profile of heat exchanger is introduced. The size and cost of printed circuit heat exchangers for advanced small modular reactors, which employ various coolants such as sodium, molten salts, helium, and water, are also presented.

Stability and Curving Performance of Conventional and Advanced Rail Transit Vehicles

DOT National Transportation Integrated Search

1984-01-01

Analytical studies are presented which compare the curving performance and speed capability of conventional rail transit trucks with self steering (cross-braced) and forced steering (linkages between carbody and wheelsets) radial trucks. Truck curvin...

Chemical Industry: A New Interdisciplinary Course for Secondary Schools.

ERIC Educational Resources Information Center

Nae, Nehemia; And Others

1980-01-01

Describes an advanced high school course which incorporates an industrial approach into the chemistry curriculum. Presents three case studies as examples taken from the local chemistry industry--the production of copper, bromine, and plastics. (CS)

Motorist understanding of directional messages : final report.

DOT National Transportation Integrated Search

1981-01-01

The report presents the findings of a study of motorists' perceptions of messages on interstate advance and supplemental guide signs. Approximately 5,100 questionnaires were distributed to motorists at eight rest areas on interstate highways in Virgi...

Vehicle Integrated Propulsion Research for the Study of Health Management Capabilities

NASA Technical Reports Server (NTRS)

Lekki, John D.; Simon, Donald L.; Hunter, Gary W.; Woike, Mary; Tokars, Roger P.

2012-01-01

Presentation on vehicle integrated propulsion research results and planning. This research emphasizes the testing of advanced health management sensors and diagnostics in an aircraft engine that is operated through multiple baseline and fault conditions.

Power and On-Board Propulsion System Benefit Studies at NASA GRC

NASA Technical Reports Server (NTRS)

Hoffman, David J.

2000-01-01

This paper discusses the value of systems studies that provide unbiased 'honest broker' assessments of the quantified benefits afforded by advanced technologies for specific missions. The organization, format, and approach used by the NASA Glenn Research Center (GRC) Systems Assessment Team (SAT) to perform system studies for the GRC advanced power and on-board propulsion technology development program is described. Three levels of assessments and a sensitivity analysis are explained and example results are presented. The impact of system studies results and some of the main challenges associated with systems studies are identified. A call for collaboration is made where system studies of all types from all organizations can be reviewed, providing a forum for the widest peer review to ensure accurate and unbiased technical content, and to avoid needless duplication.

CFD Assessment of Aerodynamic Degradation of a Subsonic Transport Due to Airframe Damage

NASA Technical Reports Server (NTRS)

Frink, Neal T.; Pirzadeh, Shahyar Z.; Atkins, Harold L.; Viken, Sally A.; Morrison, Joseph H.

2010-01-01

A computational study is presented to assess the utility of two NASA unstructured Navier-Stokes flow solvers for capturing the degradation in static stability and aerodynamic performance of a NASA General Transport Model (GTM) due to airframe damage. The approach is to correlate computational results with a substantial subset of experimental data for the GTM undergoing progressive losses to the wing, vertical tail, and horizontal tail components. The ultimate goal is to advance the probability of inserting computational data into the creation of advanced flight simulation models of damaged subsonic aircraft in order to improve pilot training. Results presented in this paper demonstrate good correlations with slope-derived quantities, such as pitch static margin and static directional stability, and incremental rolling moment due to wing damage. This study further demonstrates that high fidelity Navier-Stokes flow solvers could augment flight simulation models with additional aerodynamic data for various airframe damage scenarios.

Early acquisition of gender agreement in the Spanish noun phrase: starting small.

PubMed

Mariscal, Sonia

2009-01-01

Nativist and constructivist accounts differ in their characterization of children's knowledge of grammatical categories. In this paper we present research on the process of acquisition of a particular grammatical system, gender agreement in the Spanish noun phrase, in children under three years of age. The design of the longitudinal study employed presents some variations in relation to classical studies. The aim was to obtain a large corpus of NP data which would allow different types of analysis of the children's productions to be carried out. Intra-individual variability in early NP types was analyzed and measured, and an elicitation task for adjectives was used. Results show that the acquisition of NP and gender agreement is a complex process which advances as the children gradually integrate different pieces of evidence: phonological, distributional and functional. The reduction of variability as the grammatical process advances is a key feature for its explanation.

Benefits of advanced propulsion technology for the advanced supersonic transport

NASA Technical Reports Server (NTRS)

Hines, R. W.; Sabatella, J. A.

1973-01-01

Future supersonic transports will have to provide improvement in the areas of economics, range, and emissions relative to the present generation of supersonic transports, as well as meeting or improving upon FAR 36 noise goals. This paper covers the promising propulsion systems including variable-cycle engine concepts for long-range supersonic commercial transport application. The benefits of applying advanced propulsion technology to solve the economic and environmental problems are reviewed. The advanced propulsion technologies covered are in the areas of structures, materials, cooling techniques, aerodynamics, variable engine geometry, jet noise suppressors, acoustic treatment, and low-emission burners. The results of applying the advanced propulsion technology are presented in terms of improvement in overall system takeoff gross weight and return on investment.

Age, Sex, and Racial Differences in Neuroimaging Use in Acute Stroke: A Population-Based Study.

PubMed

Vagal, A; Sanelli, P; Sucharew, H; Alwell, K A; Khoury, J C; Khatri, P; Woo, D; Flaherty, M; Kissela, B M; Adeoye, O; Ferioli, S; De Los Rios La Rosa, F; Martini, S; Mackey, J; Kleindorfer, D

2017-10-01

Limited information is available regarding differences in neuroimaging use for acute stroke work-up. Our objective was to assess whether race, sex, or age differences exist in neuroimaging use and whether these differences depend on the care center type in a population-based study. Patients with stroke (ischemic and hemorrhagic) and transient ischemic attack were identified in a metropolitan, biracial population using the Greater Cincinnati/Northern Kentucky Stroke Study in 2005 and 2010. Multivariable regression was used to determine the odds of advanced imaging use (CT angiography/MR imaging/MR angiography) for race, sex, and age. In 2005 and 2010, there were 3471 and 3431 stroke/TIA events, respectively. If one adjusted for covariates, the odds of advanced imaging were higher for younger (55 years or younger) compared with older patients, blacks compared with whites, and patients presenting to an academic center and those seen by a stroke team or neurologist. The observed association between race and advanced imaging depended on age; in the older age group, blacks had higher odds of advanced imaging compared with whites (odds ratio, 1.34; 95% CI, 1.12-1.61; P < .01), and in the younger group, the association between race and advanced imaging was not statistically significant. Age by race interaction persisted in the academic center subgroup ( P < .01), but not in the nonacademic center subgroup ( P = .58). No significant association was found between sex and advanced imaging. Within a large, biracial stroke/TIA population, there is variation in the use of advanced neuroimaging by age and race, depending on the care center type. © 2017 by American Journal of Neuroradiology.

Physical activity in advanced cancer patients: a systematic review protocol.

PubMed

Lowe, Sonya S; Tan, Maria; Faily, Joan; Watanabe, Sharon M; Courneya, Kerry S

2016-03-11

Progressive, incurable cancer is associated with increased fatigue, increased muscle weakness, and reduced physical functioning, all of which negatively impact quality of life. Physical activity has demonstrated benefits on cancer-related fatigue and physical functioning in early-stage cancer patients; however, its impact on these outcomes in end-stage cancer has not been established. The aim of this systematic review is to determine the potential benefits, harms, and effects of physical activity interventions on quality of life outcomes in advanced cancer patients. A systematic review of peer-reviewed literature on physical activity in advanced cancer patients will be undertaken. Empirical quantitative studies will be considered for inclusion if they present interventional or observational data on physical activity in advanced cancer patients. Searches will be conducted in the following electronic databases: CINAHL; CIRRIE Database of International Rehabilitation Research; Cochrane Database of Systematic Reviews (CDSR); Database of Abstracts of Reviews of Effects (DARE); Cochrane Central Register of Controlled Trials (CENTRAL); EMBASE; MEDLINE; PEDro: the Physiotherapy Evidence Database; PQDT; PsycInfo; PubMed; REHABDATA; Scopus; SPORTDiscus; and Web of Science, to identify relevant studies of interest. Additional strategies to identify relevant studies will include citation searches and evaluation of reference lists of included articles. Titles, abstracts, and keywords of identified studies from the search strategies will be screened for inclusion criteria. Two independent reviewers will conduct quality appraisal using the Effective Public Health Practice Project Quality Assessment Tool for Quantitative Studies (EPHPP) and the Cochrane risk of bias tool. A descriptive summary of included studies will describe the study designs, participant and activity characteristics, and objective and patient-reported outcomes. This systematic review will summarize the current evidence base on physical activity interventions in advanced cancer patients. The findings from this systematic review will identify gaps to be explored by future research studies and inform future practice guideline development of physical activity interventions in advanced cancer patients. PROSPERO CRD42015026281.

English Language Learning Strategies Reported by Advanced Language Learners

ERIC Educational Resources Information Center

Lee, Juyeon; Heinz, Michael

2016-01-01

The purpose of the present study is to investigate effective English language learning strategies (LLSs) employed by successful language learners. The participants in this study were 20 student interpreters enrolled in the graduate school of interpretation and translation in Korea. Data on LLSs were collected through unstructured essay writing, a…

Test Design Project: Studies in Test Adequacy. Annual Report.

ERIC Educational Resources Information Center

Wilcox, Rand R.

These studies in test adequacy focus on two problems: procedures for estimating reliability, and techniques for identifying ineffective distractors. Fourteen papers are presented on recent advances in measuring achievement (a response to Molenaar); "an extension of the Dirichlet-multinomial model that allows true score and guessing to be…

Uncommons: Transforming Dusty Reading Rooms into Artefactual "Third Space" Library Learning Labs

ERIC Educational Resources Information Center

Schadl, Suzanne Michele; Nelson, Molly; Valencia, Kristen S.

2015-01-01

This article describes the implementation of two inexpensive social learning library laboratories for advanced students in Latin American and Chicana/o studies. Drawing on philosophical literature from these interdisciplinary areas and ethnic studies, these cases present a "third space" option for library learning called…

Familles d'ici et d'ailleurs (Families, Here and Abroad).

ERIC Educational Resources Information Center

McBride, Nicole Combe

1981-01-01

Presents the results of a contrastive study of French and English advertisements directed at family needs. The study, based on the work of British students attending an advanced French course, analyzes male and female roles, stereotypes, and changes, as they emerge from the language and images of advertising. (MES)

Teaching Agile Software Engineering Using Problem-Based Learning

ERIC Educational Resources Information Center

El-Khalili, Nuha H.

2013-01-01

Many studies have reported the utilization of Problem-Based Learning (PBL) in teaching Software Engineering courses. However, these studies have different views of the effectiveness of PBL. This paper presents the design of an Advanced Software Engineering course for undergraduate Software Engineering students that uses PBL to teach them Agile…

Elementary School Teachers' Use of Technology during Mathematics Teaching

ERIC Educational Resources Information Center

Polly, Drew

2014-01-01

Various educational technologies have been advanced as potential vehicles to transform teaching and learning. Still, research studies have documented that primary school teachers struggle to integrate technology in meaningful ways. This article presents the findings of a year-long study in which the author frequently observed three primary school…

7 CFR 4288.110 - Applicant eligibility.

Code of Federal Regulations, 2014 CFR

2014-01-01

... RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE PAYMENT PROGRAMS Advanced Biofuel Payment Program....119 present the requirements associated with advanced biofuel producer eligibility, biofuel... advanced biofuel producer, as defined in this subpart. (b) Eligibility determination. The Agency will...

SSME Advanced Health Management: Project Overview

NASA Technical Reports Server (NTRS)

Plowden, John

2000-01-01

This document is the viewgraphs from a presentation concerning the development of the Health Management system for the Space Shuttle Main Engine (SSME). It reviews the historical background of the SSME Advanced Health Management effort through the present final Health management configuration. The document includes reviews of three subsystems to the Advanced Health Management System: (1) the Real-Time Vibration Monitor System, (2) the Linear Engine Model, and (3) the Optical Plume Anomaly Detection system.

Science with the Advanced Gamma Ray Imaging System (AGIS)

NASA Astrophysics Data System (ADS)

Coppi, Paolo

2009-05-01

We present the scientific drivers for the Advanced Gamma Ray Imaging System (AGIS), a concept for the next-generation ground- based gamma-ray experiment, comprised of an array of ˜100 imaging atmospheric Cherenkov telescopes. Design requirements for AGIS include achieving a sensitivity an order of magnitude better than the current generation of space or ground-based instruments in the energy range of 40 GeV to ˜100 TeV. We present here an overview of the scientific goals of AGIS, including the prospects for understanding VHE phenomena in the vicinity of accreting black holes, particle acceleration in a variety of astrophysical environments, indirect detection of dark matter, study of cosmological background radiation fields, and particle physics beyond the standard model.

Design and Specification of Optical Bandpass Filters for Hubble Space Telescope (HST) Advanced Camera for Surveys (ACS)

NASA Technical Reports Server (NTRS)

Leviton, Douglas B.; Tsevetanov, Zlatan; Woodruff, Bob; Mooney, Thomas A.

1998-01-01

Advanced optical bandpass filters for the Hubble Space Telescope (HST) Advanced Camera for Surveys (ACS) have been developed on a filter-by-filter basis through detailed studies which take into account the instrument's science goals, available optical filter fabrication technology, and developments in ACS's charge-coupled-device (CCD) detector technology. These filters include a subset of filters for the Sloan Digital Sky Survey (SDSS) which are optimized for astronomical photometry using today's charge-coupled-devices (CCD's). In order for ACS to be truly advanced, these filters must push the state-of-the-art in performance in a number of key areas at the same time. Important requirements for these filters include outstanding transmitted wavefront, high transmittance, uniform transmittance across each filter, spectrally structure-free bandpasses, exceptionally high out of band rejection, a high degree of parfocality, and immunity to environmental degradation. These constitute a very stringent set of requirements indeed, especially for filters which are up to 90 mm in diameter. The highly successful paradigm in which final specifications for flight filters were derived through interaction amongst the ACS Science Team, the instrument designer, the lead optical engineer, and the filter designer and vendor is described. Examples of iterative design trade studies carried out in the context of science needs and budgetary and schedule constraints are presented. An overview of the final design specifications for the ACS bandpass and ramp filters is also presented.

Advanced beamed-energy and field propulsion concepts

NASA Technical Reports Server (NTRS)

Myrabo, L. N.

1983-01-01

Specific phenomena which might lead to major advances in payload, range and terminal velocity of very advanced vehicle propulsion are studied. The effort focuses heavily on advanced propulsion spinoffs enabled by current government-funded investigations in directed-energy technology: i.e., laser, microwave, and relativistic charged particle beams. Futuristic (post-year 2000) beamed-energy propulsion concepts which indicate exceptional promise are identified and analytically investigated. The concepts must be sufficiently developed to permit technical understanding of the physical processes involved, assessment of the enabling technologies, and evaluation of their merits over conventional systems. Propulsion concepts that can be used for manned and/or unmanned missions for purposes of solar system exploration, planetary landing, suborbital flight, transport to orbit, and escape are presented. Speculations are made on the chronology of milestones in beamed-energy propulsion development, such as in systems applications of defense, satellite orbit-raising, global aerospace transportation, and manned interplanetary carriers.

From biological and social network metaphors to coupled bio-social wireless networks

PubMed Central

Barrett, Christopher L.; Eubank, Stephen; Anil Kumar, V.S.; Marathe, Madhav V.

2010-01-01

Biological and social analogies have been long applied to complex systems. Inspiration has been drawn from biological solutions to solve problems in engineering products and systems, ranging from Velcro to camouflage to robotics to adaptive and learning computing methods. In this paper, we present an overview of recent advances in understanding biological systems as networks and use this understanding to design and analyse wireless communication networks. We expand on two applications, namely cognitive sensing and control and wireless epidemiology. We discuss how our work in these two applications is motivated by biological metaphors. We believe that recent advances in computing and communications coupled with advances in health and social sciences raise the possibility of studying coupled bio-social communication networks. We argue that we can better utilise the advances in our understanding of one class of networks to better our understanding of the other. PMID:21643462

Recent advances in radiation cancer therapy

NASA Astrophysics Data System (ADS)

Ma, C.-M. Charlie

2007-03-01

This paper presents the recent advances in radiation therapy techniques for the treatment of cancer. Significant improvement has been made in imaging techniques such as CT, MRI, MRS, PET, ultrasound, etc. that have brought marked advances in tumor target and critical structure delineation for treatment planning and patient setup and target localization for accurate dose delivery in radiation therapy of cancer. Recent developments of novel treatment modalities including intensity-modulated x-ray therapy (IMXT), energy- and intensity modulated electron therapy (MERT) and intensity modulated proton therapy (IMPT) together with the use of advanced image guidance have enabled precise dose delivery for dose escalation and hypofractionation studies that may result in better local control and quality of life. Particle acceleration using laser-induced plasmas has great potential for new cost-effective radiation sources that may have a great impact on the management of cancer using radiation therapy.

Advances in multi-scale modeling of solidification and casting processes

NASA Astrophysics Data System (ADS)

Liu, Baicheng; Xu, Qingyan; Jing, Tao; Shen, Houfa; Han, Zhiqiang

2011-04-01

The development of the aviation, energy and automobile industries requires an advanced integrated product/process R&D systems which could optimize the product and the process design as well. Integrated computational materials engineering (ICME) is a promising approach to fulfill this requirement and make the product and process development efficient, economic, and environmentally friendly. Advances in multi-scale modeling of solidification and casting processes, including mathematical models as well as engineering applications are presented in the paper. Dendrite morphology of magnesium and aluminum alloy of solidification process by using phase field and cellular automaton methods, mathematical models of segregation of large steel ingot, and microstructure models of unidirectionally solidified turbine blade casting are studied and discussed. In addition, some engineering case studies, including microstructure simulation of aluminum casting for automobile industry, segregation of large steel ingot for energy industry, and microstructure simulation of unidirectionally solidified turbine blade castings for aviation industry are discussed.

Advances in Decoding Breast Cancer Brain Metastasis

PubMed Central

Zhang, Chenyu; Yu, Dihua

2016-01-01

The past decade has witnessed impressive advances in cancer treatment ushered in by targeted and immunotherapies. However, with significantly prolonged survival, upon recurrence, more patients become inflicted by brain metastasis, which is mostly refractory to all currently available therapeutic regimens. Historically, brain metastasis is an understudied area in cancer research, partly due to the dearth of appropriate experimental models that closely simulate the special biological features of metastasis in the unique brain environment; and to the sophistication of techniques required to perform in-depth studies of the extremely complex and challenging brain metastasis. Yet, with increasing clinical demand for more effective treatment options, brain metastasis research has rapidly advanced in recent years. The present review spotlights the recent major progresses in basic and translational studies of brain metastasis with focuses on new animal models, novel imaging technologies, omics “big data” resources, and some new and exciting biological insights on brain metastasis. PMID:27873078

Evaluation of 3-D graphics software: A case study

NASA Technical Reports Server (NTRS)

Lores, M. E.; Chasen, S. H.; Garner, J. M.

1984-01-01

An efficient 3-D geometry graphics software package which is suitable for advanced design studies was developed. The advanced design system is called GRADE--Graphics for Advanced Design. Efficiency and ease of use are gained by sacrificing flexibility in surface representation. The immediate options were either to continue development of GRADE or to acquire a commercially available system which would replace or complement GRADE. Test cases which would reveal the ability of each system to satisfy the requirements were developed. A scoring method which adequately captured the relative capabilities of the three systems was presented. While more complex multi-attribute decision methods could be used, the selected method provides all the needed information without being so complex that it is difficult to understand. If the value factors are modestly perturbed, system Z is a clear winner based on its overall capabilities. System Z is superior in two vital areas: surfacing and ease of interface with application programs.

Advanced Colloids Experiment (Microscopy) - ACE-M2R

NASA Technical Reports Server (NTRS)

Weitz, David; Meyer, William V.; Sicker, Ronald J.; Bailey, Kelly Ann; Eustace, John G.

2017-01-01

Increment 53 - 54 Science Symposium presentation of Advanced Colloids Experiment (ACE-H-2) to RPO. The purpose of this event is for Principal Investigators to present their science objectives, testing approach, and measurement methods to agency scientists, managers, and other investigators.

Advanced Colloids Experiment (Temperature Controlled) - ACE-T9

NASA Technical Reports Server (NTRS)

Marr, David W. M.; Meyer, William V.; Sicker, Ronald; Bailey, Kelly; Eustace, John G.

2017-01-01

Increment 53 - 54 Science Symposium presentation of Advanced Colloids Experiment (ACE-T9) to RPO. The purpose of this event is for Principal Investigators to present their science objectives, testing approach, and measurement methods to agency scientists, managers, and other investigators.

Advanced Colloids Experiment (Temperature Controlled) - ACE-T6

NASA Technical Reports Server (NTRS)

Meyer, William V.; Sicker, Ron; Bailey, Kelly; Eustace, John; Abbott-Hearn, Amber; Lynch, Matthew

2016-01-01

Increment 51 - 52 Science Symposium presentation of Advanced Colloids Experiment (ACE-T6) to RPO. The purpose of this event is for Principal Investigators to present their science objectives, testing approach, and measurement methods to agency scientists, managers, and other investigators.

Advanced Colloids Experiment (Temperature Controlled) - ACE-T6

NASA Technical Reports Server (NTRS)

Meyer, William V.; Sicker, Ronald J.; Bailey, Kelly; Eustace, John; Lynch, Matthew

2017-01-01

Increment 53 - 54 Science Symposium presentation of Advanced Colloids Experiment (ACE-T6) to RPO. The purpose of this event is for Principal Investigators to present their science objectives, testing approach, and measurement methods to agency scientists, managers, and other investigators.

Development of improved coating for advanced carbon-carbon components

NASA Technical Reports Server (NTRS)

Yamaki, Y. R.; Brown, J. J.

1984-01-01

Reaction sintered silicon nitride (RSSN) was studied as a substitute coating material on the carbon-carbon material (RCC) presently used as a heat shield on the space shuttle, and on advanced carbon-carbon (ACC), a later development. On RCC, RSSN showed potential in a 538 C (1000 F) screening test in which silicon carbide coated material exhibits its highest oxidation rate; RSSN afforded less protection to ACC because of a larger thermal expansion mismatch. Organosilicon densification and metallic silicon sealing methods were studied as means of further increasing the oxidation resistance of the coating, and some improvement was noted when these methods were employed.

A three-level advanced static VAr compensator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ekanayake, J.B.; Jenkins, N.

1996-01-01

An Advanced Static VAr Compensator (ASVC) employing a three level inverter has been investigated for three phase applications. The paper describes the operating principles of the ASVC using an elementary single phase ASVC circuit. The construction of a hardware model of the three phase, three level ASVC is then presented. The performance of the ASVC is obtained from an experimental study carried out on this laboratory model. The use of the selective harmonic elimination modulation (SHEM) technique to minimize harmonics is explored. Experimental studies have been carried out to determine the speed of response of the scheme by controlling itmore » in a closed loop.« less

Advancements in mass spectrometry for biological samples: Protein chemical cross-linking and metabolite analysis of plant tissues

DOE Office of Scientific and Technical Information (OSTI.GOV)

Klein, Adam

2015-01-01

This thesis presents work on advancements and applications of methodology for the analysis of biological samples using mass spectrometry. Included in this work are improvements to chemical cross-linking mass spectrometry (CXMS) for the study of protein structures and mass spectrometry imaging and quantitative analysis to study plant metabolites. Applications include using matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) to further explore metabolic heterogeneity in plant tissues and chemical interactions at the interface between plants and pests. Additional work was focused on developing liquid chromatography-mass spectrometry (LC-MS) methods to investigate metabolites associated with plant-pest interactions.

Variable/Multispeed Rotorcraft Drive System Concepts

NASA Technical Reports Server (NTRS)

Stevens, Mark A.; Handschuh, Robert F.; Lewicki, David G.

2009-01-01

Several recent studies for advanced rotorcraft have identified the need for variable, or multispeed-capable rotors. A speed change of up to 50 percent has been proposed for future rotorcraft to improve vehicle performance. Varying rotor speed during flight not only requires a rotor capable of performing effectively over the extended operation speed and load range, but also requires an advanced propulsion system to provide the required speed changes. A study has been completed, which investigated possible drive system arrangements to accommodate up to the 50 percent speed change. These concepts are presented. The most promising configurations are identified and will be developed for future validation testing.

Application of computational physics within Northrop

NASA Technical Reports Server (NTRS)

George, M. W.; Ling, R. T.; Mangus, J. F.; Thompkins, W. T.

1987-01-01

An overview of Northrop programs in computational physics is presented. These programs depend on access to today's supercomputers, such as the Numerical Aerodynamical Simulator (NAS), and future growth on the continuing evolution of computational engines. Descriptions here are concentrated on the following areas: computational fluid dynamics (CFD), computational electromagnetics (CEM), computer architectures, and expert systems. Current efforts and future directions in these areas are presented. The impact of advances in the CFD area is described, and parallels are drawn to analagous developments in CEM. The relationship between advances in these areas and the development of advances (parallel) architectures and expert systems is also presented.

Radical Prostatectomy for Locally Advanced Prostate Cancers-Review of Literature.

PubMed

Srivatsa, N; Nagaraja, H; Shweta, S; Raghunath, S K

2017-06-01

Twenty-five to thirty percent of patients with prostate cancer present with locally advanced disease. While risk stratification remains the same with high incidence of upstaging of disease on imaging and histopathological evaluation; there have been progressive refinements in surgical therapy. With availability of reasonably robust data, radical prostatectomy in men with locally advanced prostate cancers seems to effect improvement in both cancer specific and overall survival rates in comparison to the current standard of care of radiation with androgen deprivation therapy. Studies using radical prostatectomy as a part of multimodality approach have also shown promising results. There is an imminent need for well-designed prospective studies of benefits of radical prostatectomy over radiation and androgen deprivation as well as benefits of multimodality therapy over monotherapy. Surgery for patients with locally advanced prostate cancer is technically challenging. Surgical outcomes are comparable to those of organ-confined disease when performed in high-volume centers. Neoadjuvant therapies prior to radical prostatectomy might improve surgical outcomes, but whether they will translate into a better cancer specific and overall survival are yet to be ascertained.

Laser immunotherapy for treatment of patients with advanced breast cancer and melanoma

NASA Astrophysics Data System (ADS)

Li, Xiaosong; Hode, Tomas; Guerra, Maria C.; Ferrel, Gabriela L.; Nordquist, Robert E.; Chen, Wei R.

2011-02-01

Laser immunotherapy (LIT) was developed for the treatment of metastatic tumors. It combines local selective photothermal interaction and active immunological stimulation to induce a long-term, systemic anti-tumor immunity. During the past sixteen years, LIT has been advanced from bench-top to bedside, with promising outcomes. In our pre-clinical and preliminary clinical studies, LIT has demonstrated the capability in inducing immunological responses, which not only can eradicate the treated primary tumors, but also can eliminate untreated metastases at distant sites. Specifically, LIT has been used to treat advanced melanoma and breast cancer patients during the past five years. LIT was shown to be effective in controlling both primary tumors and distant metastases in late-stage patients, who have failed conventional therapies such as surgery, chemotherapy, radiation, and other more advanced approaches. The methodology and the development of LIT are presented in this paper. The patients' responses to LIT are also reported in this paper. The preliminary results obtained in these studies indicated that LIT could be an effective modality for the treatment of patients with late-stage, metastatic cancers, who are facing severely limited options.

Phase 1 Study of Erlotinib Plus Radiation Therapy in Patients With Advanced Cutaneous Squamous Cell Carcinoma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heath, C. Hope; Deep, Nicholas L.; Nabell, Lisle

Purpose: To assess the toxicity profile of erlotinib therapy combined with postoperative adjuvant radiation therapy in patients with advanced cutaneous squamous cell carcinoma. Methods and Materials: This was a single-arm, prospective, phase 1 open-label study of erlotinib with radiation therapy to treat 15 patients with advanced cutaneous head-and-neck squamous cell carcinoma. Toxicity data were summarized, and survival was analyzed with the Kaplan-Meier method. Results: The majority of patients were male (87%) and presented with T4 disease (93%). The most common toxicity attributed to erlotinib was a grade 2-3 dermatologic reaction occurring in 100% of the patients, followed by mucositis (87%).more » Diarrhea occurred in 20% of the patients. The 2-year recurrence rate was 26.7%, and mean time to cancer recurrence was 10.5 months. Two-year overall survival was 65%, and disease-free survival was 60%. Conclusions: Erlotinib and radiation therapy had an acceptable toxicity profile in patients with advanced cutaneous squamous cell carcinoma. The disease-free survival in this cohort was comparable to that in historical controls.« less

The relationship between antiglycation activity and procyanidin and phenolic content in commercial grape seed products.

PubMed

Sun, Cathy; McIntyre, Kristina; Saleem, Ammar; Haddad, Pierre Selim; Arnason, John Thor

2012-02-01

Eight commercial grape seed products (GSPs) were assessed for their inhibition of the formation of advanced glycation end-products in vitro. All 8 commercial GSPs included in this study were potent inhibitors of advanced glycation end-product formation with IC(50) values ranging from 2.93 to 20.0 µg/mL. Total procyanidin content ranged from 60% to 73%. HPLC-DAD-ELSD results indicate that (+)-catechin, (-)-epicatechin, procyanidin B1, and procyanidin B2 were predominant and ubiquitously present in all the products under study, while gallic acid and procyanidin B4 were present in relatively minor amounts. The IC(50) values correlated with total phenolic content, and multiple regression analysis indicated that IC(50) is a linear function of the concentration of gallic acid and procyanidins B1, B2, and B4. Based on this study, GSPs have the potential to complement conventional diabetes medication toward disease management and prevention.

Effects of Exercise on Functional Performance and Fall Rate in Subjects with Mild or Advanced Alzheimer's Disease: Secondary Analyses of a Randomized Controlled Study.

PubMed

Öhman, Hannareeta; Savikko, Niina; Strandberg, Timo; Kautiainen, Hannu; Raivio, Minna; Laakkonen, Marja-Liisa; Tilvis, Reijo; Pitkälä, Kaisu H

2016-01-01

Exercise improves functional performance in subjects with dementia. However, whether the benefits of exercise are evident in all stages of dementia remains uncertain. This study examines how people in different stages of Alzheimer's disease (AD) benefit from exercise intervention in their physical functioning and risk of falling. The present study is a subanalysis of a randomized controlled trial examining the effects of exercise intervention (twice a week for 12 months) in AD patients (n = 194). We studied the effects separately in participants with mild dementia and in participants with advanced dementia. In subjects with mild dementia, the deterioration in physical functioning was slower in the intervention group than in the controls. Changes in Functional Independence Measure at 12 months were -2.7 (95% CI -0.5 to -4.9) in the intervention group and -10.1 (95% CI -7.0 to -13.3) in the control group (p < 0.001). The exercise intervention proved effective in preventing falls among patients with advanced AD, with an incidence rate ratio of 0.47 (95% CI 0.37-0.60; p < 0.001). Regular exercise may slow the rate of functional deterioration in mild AD and reduce falls in patients suffering from advanced AD. © 2016 S. Karger AG, Basel.

Advances in ice mechanics - 1987

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chung, J.S.; Hallam, S.D.; Maatanen, M.

1987-01-01

This book presents the papers given at a symposium on the interaction of icebergs with offshore platforms. Topics considered at the symposium included advances in ice mechanics in the United Kingdom, ice mechanics in Finland, recent advances in ice mechanics in Canada, advances in sea ice mechanics in the USA, foundations, monitoring, hazards, risk assessment, and deformation.

Advanced Life Support Systems

NASA Technical Reports Server (NTRS)

Barta, Daniel J.

2004-01-01

This presentation is planned to be a 10-15 minute "catalytic" focused presentation to be scheduled during one of the working sessions at the TIM. This presentation will focus on Advanced Life Support technologies key to future human Space Exploration as outlined in the Vision, and will include basic requirements, assessment of the state-of-the-art and gaps, and include specific technology metrics. The presentation will be technical in character, lean heavily on data in published ALS documents (such as the Baseline Values and Assumptions Document) but not provide specific technical details or build to information on any technology mentioned (thus the presentation will be benign from an export control and a new technology perspective). The topics presented will be focused on the following elements of Advanced Life Support: air revitalization, water recovery, waste management, thermal control, habitation systems, food systems and bioregenerative life support.

Advances in the study on endogenous sulfur dioxide in the cardiovascular system.

PubMed

Tian, Hong

2014-01-01

This review summarized the current advances in understanding the role of the novel gasotransmitter, sulfur dioxide (SO2), in the cardiovascular system. Articles on the advances in the study of the role of endogenous sulfur dioxide in the cardiovascular system were accessed from PubMed and CNKI from 2003 to 2013, using keywords such as "endogenous sulfur dioxide" and "cardiovascular system". Articles with regard to the role of SO2 in the regulation of cardiovascular system were selected. Recently, scientists discovered that an endogenous SO2 pathway is present in the cardiovascular system and exerts physiologically significant effects, such as regulation of the cardiac function and the pathogenesis of various cardiopulmonary diseases such as hypoxic pulmonary hypertension, hypertension, coronary atherosclerosis, and cardiac ischemia-reperfusion (I/R) injury, in the cardiovascular system. Endogenous SO2 is a novel member of the gasotransmitter family in addition to the nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S). Studies indicated that it has a role in regulating the cardiovascular disease.

Management of advanced gastric cancer: An overview of major findings from meta-analysis

PubMed Central

Cai, Danxian; Li, Wende; Hui, Jialiang; Liu, Chuan; Zhao, Yanxia; Li, Guoxin

2016-01-01

This study aims to provide an overview of different treatment for advanced gastric cancer. In the present study, we systematically reviewed the major findings from relevant meta-analyses. A total of 54 relevant papers were searched via the PubMed, Web of Science, and Google scholar databases. They were classified according to the mainstay treatment modalities such as surgery, chemotherapy and others. Primary outcomes including overall survival, response rate, disease-free survival, recurrence-free survival, progression-free survival, time-to-progression, time-to failure, recurrence and safety were summarized. The recommendations and uncertainties regarding the treatment of advanced gastric cancer were also proposed. It was suggested that laparoscopic gastrectomy was a safe and technical alternative to open gastrectomy. Besides, neoadjuvant chemotherapy and adjuvant chemotherapy were thought to benefit the survival over surgery alone. And it was demonstrated in the study that targeted therapy like anti-angiogenic and anti-HER2 agents but anti-EGFR agent might have a significant survival benefit. PMID:27655725

Integrated Power and Attitude Control Systems for Space Station

NASA Technical Reports Server (NTRS)

Oglevie, R. E.; Eisenhaure, D. B.

1985-01-01

Integrated Power and Attitude Control Systems (IPACS) studies performed over a decade ago established the feasibility of simultaneously storing electrical energy in wheels and utilizing the resulting momentum for spacecraft attitude control. It was shown that such a system possessed many advantages over other contemporary energy storage and attitude control systems in many applications. More recent technology advances in composite rotors, magnetic bearings, and power control electronics have triggered new optimism regarding the feasibility and merits of such a system. The paper presents the results of a recent study whose focus was to define an advanced IPACS and to evaluate its merits for the Space Station application. A system and component design concept is developed to establish the system performance capability. A system level trade study, including life-cycle costing, is performed to define the merits of the system relative to two other candidate systems. It is concluded that an advanced IPACS concept is not only feasible, but offers substantial savings in mass, and life-cycle cost.

Health disparities and impact on outcomes in children with primary central nervous system solid tumors.

PubMed

Austin, Mary T; Hamilton, Emma; Zebda, Denna; Nguyen, Hoang; Eberth, Jan M; Chang, Yuchia; Elting, Linda S; Sandberg, David I

2016-11-01

OBJECTIVE Health disparities in access to care, early detection, and survival exist among adult patients with cancer. However, there have been few reports assessing how health disparities impact pediatric patients with malignancies. The objective in this study was to examine the impact of racial/ethnic and social factors on disease presentation and outcome for children with primary CNS solid tumors. METHODS The authors examined all children (age ≤ 18 years) in whom CNS solid tumors were diagnosed and who were enrolled in the Texas Cancer Registry between 1995 and 2009 (n = 2421). Geocoded information was used to calculate the driving distance between a patient's home and the nearest pediatric cancer treatment center. Socioeconomic status (SES) was determined using the Agency for Healthcare Research and Quality formula and 2007-2011 US Census block group data. Logistic regression was used to determine factors associated with advanced-stage disease. Survival probability and hazard ratios were calculated using life table methods and Cox regression. RESULTS Children with advanced-stage CNS solid tumors were more likely to be < 1 year old, Hispanic, and in the lowest SES quartile (all p < 0.05). The adjusted odds ratios of presenting with advanced-stage disease were higher in children < 1 year old compared with children > 10 years old (OR 1.71, 95% CI 1.06-2.75), and in Hispanic patients compared with non-Hispanic white patients (OR 1.56, 95% CI 1.19-2.04). Distance to treatment and SES did not impact disease stage at presentation in the adjusted analysis. Furthermore, 1- and 5-year survival probability were worst in children 1-10 years old, Hispanic patients, non-Hispanic black patients, and those in the lowest SES quartile (p < 0.05). In the adjusted survival model, only advanced disease and malignant behavior were predictive of mortality. CONCLUSIONS Racial/ethnic disparities are associated with advanced-stage disease presentation for children with CNS solid tumors. Disease stage at presentation and tumor behavior are the most important predictors of survival.

Robotics, stem cells, and brain-computer interfaces in rehabilitation and recovery from stroke: updates and advances.

PubMed

Boninger, Michael L; Wechsler, Lawrence R; Stein, Joel

2014-11-01

The aim of this study was to describe the current state and latest advances in robotics, stem cells, and brain-computer interfaces in rehabilitation and recovery for stroke. The authors of this summary recently reviewed this work as part of a national presentation. The article represents the information included in each area. Each area has seen great advances and challenges as products move to market and experiments are ongoing. Robotics, stem cells, and brain-computer interfaces all have tremendous potential to reduce disability and lead to better outcomes for patients with stroke. Continued research and investment will be needed as the field moves forward. With this investment, the potential for recovery of function is likely substantial.

Recent advances in research on Crimean-Congo hemorrhagic fever.

PubMed

Papa, Anna; Mirazimi, Ali; Köksal, Iftihar; Estrada-Pena, Augustin; Feldmann, Heinz

2015-03-01

Crimean-Congo hemorrhagic fever (CCHF) is an expanding tick-borne hemorrhagic disease with increasing human and animal health impact. Immense knowledge was gained over the past 10 years mainly due to advances in molecular biology, but also driven by an increased global interest in CCHFV as an emerging/re-emerging zoonotic pathogen. In the present article, we discuss the advances in research with focus on CCHF ecology, epidemiology, pathogenesis, diagnostics, prophylaxis and treatment. Despite tremendous achievements, future activities have to concentrate on the development of vaccines and antivirals/therapeutics to combat CCHF. Vector studies need to continue for better public and animal health preparedness and response. We conclude with a roadmap for future research priorities. Copyright © 2014 Elsevier B.V. All rights reserved.

An incidence model of the cost of advanced prostate cancer in Spain.

PubMed

Hart, W M; Nazir, J; Baskin-Bey, E

2014-02-01

Prostate cancer (PCa) is the second leading cancer diagnosed among men. In Spain the incidence of PCa was 70.75 cases per 100,000 males. Advanced PCa has spread outside of the prostate capsule and may involve other parts of the body. The aim of this study was to estimate the lifetime costs of a cohort of advanced PCa patients diagnosed in Spain in 2012. A partitioned economic model was developed in EXCEL incorporating Spanish incidence, mortality, and cost data supplemented with data from the international literature. Progression from Stage III to Stage IV was permitted. Costs were discounted at the standard rate of 3%. Lifetime costs were presented on an individual basis and for the entire cohort of newly diagnosed Stage III and Stage IV PCa patients. Lifetime costs for advanced PCa were ∼€19,961 per patient (mean survival of 8.4 years). Using the projected incident cases for 2012 (3047), the total cost for the incident cohort of patients in 2012 would amount to €61 million. These results were more sensitive to changes in the ongoing costs (post-initial 12 months) of Stage III PCa, the rate of progression from Stage III to Stage IV, and the discount rate applied to costs. This study provides an estimate of the lifetime costs of advanced PCa in Spain and a framework for further research. The study is limited by the availability of long-term Spanish data and the need to make inferences from international studies. However, until long-term prospective or observational data do become available in Spain, based on the assumptions, the current results indicate that the burden of advanced PCa in Spain is substantial. Any treatments that could potentially reduce the economic burden of the disease should be of interest to healthcare decision makers.

Cells in Spaceflight: Past, Present and Future

NASA Technical Reports Server (NTRS)

1999-01-01

The center for advanced studies in the Space Life Sciences provides a forum for scientist to think and discuss, often for the first time, the role that gravity and aspects of spaceflight may play in fundamental cellular and physiologic processes.

Study to Establish Ride Comfort Criteria for High Speed Magnetically Levitated Transportation Systems

DOT National Transportation Integrated Search

1994-06-01

Advanced high speed fixed guideway transportation systems such as magnetic levitation systems have speed, acceleration, : and banking capabilities which present new guideway design issues. This increased performance results in new concerns : for pass...

Advanced Propulsion for the XXIst Century

NASA Technical Reports Server (NTRS)

Frisbee, Robert H.

2003-01-01

This document represents a poster presentation offered at the AIAA/CAS International Air & Space Symposium and Exposition from July 14-17, 2003 in Dayton Ohio. This presentation outlines advanced space propulsion concepts as well as associated research and industry activities during the 21st century.

The Relation between Students' Math and Reading Ability and Their Mathematics, Physics, and Chemistry Examination Grades in Secondary Education

ERIC Educational Resources Information Center

Korpershoek, Hanke; Kuyper, Hans; van der Werf, Greetje

2015-01-01

Word problems are math- or science-related problems presented in the context of a story or real-life scenario. Literature suggests that, to solve these problems, advanced reading skills are required, in addition to content-related skills in, for example, mathematics. In the present study, we investigated the relation between students' reading…

NASA gear research and its probable effect on rotorcraft transmission design

NASA Technical Reports Server (NTRS)

Zaretsky, E. V.; Townsend, D. P.; Coy, J. J.

1979-01-01

The results of the NASA gear research is reviewed as well as those programs which are presently being undertaken. Research programs studying pitting fatigue, gear steels and processing, life prediction methods, gear design and dynamics, elastohydrodynamic lubrication, lubrication methods and gear noise are presented. The impact of advanced gear research technology on rotorcraft transmission design is discussed.

Cosmos, an international center for advanced studies

NASA Technical Reports Server (NTRS)

Ryzhov, Iurii; Alifanov, Oleg; Sadin, Stanley; Coleman, Paul

1990-01-01

The concept of Cosmos, a Soviet operating center for aerospace activities, is presented. The main Cosmos participants are the Institute for Aerospace Education, the Institute for Research and Commercial Development, and the Department of Space Policy and Socio-Economic Studies. Cosmos sponsors a number of educational programs, basic research, and studies of the social impact of space-related technologies.

Assessing Fat Mass of Adolescent Swimmers Using Anthropometric Equations: A DXA Validation Study

ERIC Educational Resources Information Center

Lozano-Berges, Gabriel; Gómez-Bruton, Alejandro; Matute-Llorente, Ángel; Julián-Almárcegui, Cristina; Gómez-Cabello, Alba; González-Agüero, Alejandro; Casajús, José A.; Vicente-Rodríguez, Germán

2017-01-01

Purpose: The aim of the present study was to determine which of the published anthropometric equations is the most appropriate to estimate body-fat percentage (BF%) in adolescent swimmers. Method: Eighty-eight swimmers (45 boys, 43 girls) participated in this study. Following the recommendations of the International Society of the Advancement of…

Reports on Swedish Projects Relevant to the Study of Impromptu Speech: FUMS.

ERIC Educational Resources Information Center

Nordberg, Bengt

The Unit for Advanced Studies in Modern Swedish (FUMS) at Uppsala University has one of the largest collections of spontaneous present-day spoken Swedish and has housed many sociolinguistic research projects since the 1960s. The four studies generating the most empirical data are on: The Urban Dialect of Eskilstuna; The Child's Linguistic…

Factors Influencing Singapore Students' Choice of Physics as a Tertiary Field of Study: A Rasch Analysis

ERIC Educational Resources Information Center

Oon, Pey-Tee; Subramaniam, R.

2013-01-01

Asian students often perform well in international science and mathematics assessments. Their attitude toward technical subjects, such as physics, remains curious for many. The present study examines Singapore school students' views on various aspects of physics according to whether they intend to choose physics as an advanced field of study. A…

"EXHALE": exercise as a strategy for rehabilitation in advanced stage lung cancer patients: a randomized clinical trial comparing the effects of 12 weeks supervised exercise intervention versus usual care for advanced stage lung cancer patients.

PubMed

Quist, Morten; Langer, Seppo W; Rørth, Mikael; Christensen, Karl Bang; Adamsen, Lis

2013-10-14

Lung cancer is the leading cause of cancer death in North America and Western Europe. Patients with lung cancer in general have reduced physical capacity, functional capacity, poor quality of life and increased levels of anxiety and depression. Intervention studies indicate that physical training can address these issues. However, there is a lack of decisive evidence regarding the effect of physical exercise in patients with advanced lung cancer. The aim of this study is to evaluate the effects of a twelve weeks, twice weekly program consisting of: supervised, structured training in a group of advanced lung cancer patients (cardiovascular and strength training, relaxation). A randomized controlled trial will test the effects of the exercise intervention in 216 patients with advanced lung cancer (non-small cell lung cancer (NSCLC) stage IIIb-IV and small cell lung cancer (SCLC) extensive disease (ED)). Primary outcome is maximal oxygen uptake (VO₂peak). Secondary outcomes are muscle strength (1RM), functional capacity (6MWD), lung capacity (Fev1) and patient reported outcome (including anxiety, depression (HADS) and quality of life (HRQOL)). The present randomized controlled study will provide data on the effectiveness of a supervised exercise intervention in patients receiving systemic therapy for advanced lung cancer. It is hoped that the intervention can improve physical capacity and functional level, during rehabilitation of cancer patients with complex symptom burden and help them to maintain independent function for as long as possible. http://ClinicalTrials.gov, NCT01881906.

Combining traditional dietary assessment methods with novel metabolomics techniques: present efforts by the Food Biomarker Alliance.

PubMed

Brouwer-Brolsma, Elske M; Brennan, Lorraine; Drevon, Christian A; van Kranen, Henk; Manach, Claudine; Dragsted, Lars Ove; Roche, Helen M; Andres-Lacueva, Cristina; Bakker, Stephan J L; Bouwman, Jildau; Capozzi, Francesco; De Saeger, Sarah; Gundersen, Thomas E; Kolehmainen, Marjukka; Kulling, Sabine E; Landberg, Rikard; Linseisen, Jakob; Mattivi, Fulvio; Mensink, Ronald P; Scaccini, Cristina; Skurk, Thomas; Tetens, Inge; Vergeres, Guy; Wishart, David S; Scalbert, Augustin; Feskens, Edith J M

2017-11-01

FFQ, food diaries and 24 h recall methods represent the most commonly used dietary assessment tools in human studies on nutrition and health, but food intake biomarkers are assumed to provide a more objective reflection of intake. Unfortunately, very few of these biomarkers are sufficiently validated. This review provides an overview of food intake biomarker research and highlights present research efforts of the Joint Programming Initiative 'A Healthy Diet for a Healthy Life' (JPI-HDHL) Food Biomarkers Alliance (FoodBAll). In order to identify novel food intake biomarkers, the focus is on new food metabolomics techniques that allow the quantification of up to thousands of metabolites simultaneously, which may be applied in intervention and observational studies. As biomarkers are often influenced by various other factors than the food under investigation, FoodBAll developed a food intake biomarker quality and validity score aiming to assist the systematic evaluation of novel biomarkers. Moreover, to evaluate the applicability of nutritional biomarkers, studies are presently also focusing on associations between food intake biomarkers and diet-related disease risk. In order to be successful in these metabolomics studies, knowledge about available electronic metabolomics resources is necessary and further developments of these resources are essential. Ultimately, present efforts in this research area aim to advance quality control of traditional dietary assessment methods, advance compliance evaluation in nutritional intervention studies, and increase the significance of observational studies by investigating associations between nutrition and health.

The Advanced Glaucoma Intervention Study (AGIS): 1. Study design and methods and baseline characteristics of study patients.

PubMed

Ederer, F; Gaasterland, D E; Sullivan, E K

1994-08-01

Medical therapy has been the standard initial treatment for open-angle glaucoma. When some visual field has been lost and maximum tolerated and effective medical therapy does not succeed in controlling the disease, the patient is considered to have advanced glaucoma, and the first of a potential sequence of surgical treatments is usually indicated. Little is known about the long-term course and prognosis of advanced glaucoma or about the long-term effectiveness of sequential surgical treatments in controlling the disease and preventing vision loss and blindness. The Advanced Glaucoma Intervention Study was designed to study, in advanced glaucoma, the long-term clinical course and prognosis, and, in a randomized trial, the comparative outcomes of two sequences of surgical treatments. Toward these goals, 789 eyes in 591 patients were enrolled at 11 clinical centers between 1988 and 1992. Follow-up will continue until 1996. Eyes were randomly assigned to one of two sequences of surgical treatments. One sequence begins with argon laser trabeculoplasty (ALT), is followed by trabeculectomy, an incisional surgical filtering procedure, should ALT fail to control the disease, and by a second trabeculectomy should the first trabeculectomy fail. The other sequence begins with trabeculectomy, is followed by ALT should the trabeculectomy fail, and by a second trabeculectomy should ALT fail. The main outcome of interest is visual function (visual field and visual acuity). Other important outcomes are intraocular pressure, complications of surgery, time to treatment failure, and extent of need for additional medical therapy. We present in this paper the rationale, objectives, design and methods of the study, and the baseline characteristics of study patients and eyes.

Advanced pediatric mastoiditis with and without intracranial complications.

PubMed

Zevallos, Jose P; Vrabec, Jeffrey T; Williamson, Robert A; Giannoni, Carla; Larrier, Deidre; Sulek, Marcelle; Friedman, Ellen M; Oghalai, John S

2009-08-01

Recently, several groups have noticed an increase in cases of advanced pediatric mastoiditis and intracranial complications. The objective of this study was to review the bacteriology of advanced mastoiditis in pediatric patients, with the hypothesis that a difference in bacteriology might explain the development of an intracranial complication. Retrospective chart review. All pediatric patients with coalescent mastoiditis requiring surgery treated at a tertiary care children's hospital between 2002 and 2007 were reviewed. Every patient included was treated either with mastoidectomy alone (for coalescent mastoiditis without an intracranial complication) or with transtemporal craniotomy (for coalescent mastoiditis with an intracranial complication). All patients had surgical specimens sent for pathology, Gram stain, and aerobic and anaerobic cultures. One hundred eight pediatric patients with coalescent mastoiditis were identified: 58 (53%) presented with coalescent mastoiditis alone, 17 (16%) presented with coalescent mastoiditis and an intracranial complication, and 33 (31%) were excluded because they were treated with myringotomy and tubes alone, had incomplete data, or had an unclear diagnosis. Streptococcus pneumoniae was the most commonly cultured organism in patients with and without intracranial complications. Anaerobic isolates were present in 29.4% of patients with intracranial complications and 5.7% of patients without intracranial complications (P = .015). Nearly a quarter of pediatric patients with coalescent mastoiditis presented with a simultaneous intracranial complication. There was an increased incidence of anaerobic organisms in patients with intracranial complications compared to those without, indicating the importance of culture and antibiotic coverage appropriate for anaerobes. This series demonstrates the role of aggressive surgical management and close collaboration with the infectious disease service for long-term intravenous antibiotic therapy in treating pediatric patients with advanced mastoiditis.

Missed opportunities for earlier diagnosis of HIV in patients who presented with advanced HIV disease: a retrospective cohort study

PubMed Central

Levy, Itzchak; Maor, Yasmin; Mahroum, Naim; Olmer, Liraz; Wieder, Anat; Litchevski, Vladislav; Mor, Orna; Rahav, Galia

2016-01-01

Objective To quantify and characterise missed opportunities for earlier HIV diagnosis in patients diagnosed with advanced HIV. Design A retrospective observational cohort study. Setting A central tertiary medical centre in Israel. Measures The proportion of patients with advanced HIV, the proportion of missed opportunities to diagnose them earlier, and the rate of clinical indicator diseases (CIDs) in those patients. Results Between 2010 and 2015, 356 patients were diagnosed with HIV, 118 (33.4%) were diagnosed late, 57 (16%) with advanced HIV disease. Old age (OR=1.45 (95% CI 1.16 to 1.74)) and being heterosexual (OR=2.65 (95% CI 1.21 to 5.78)) were significant risk factors for being diagnosed late. All patients with advanced disease had at least one CID that did not lead to an HIV test in the 5 years prior to AIDS diagnosis. The median time between CID and AIDS diagnosis was 24 months (IQR 10–30). 60% of CIDs were missed by a general practitioner and 40% by a specialist. Conclusions Missed opportunities to early diagnosis of HIV occur in primary and secondary care. Lack of national guidelines, lack of knowledge regarding CIDs and communication barriers with patients may contribute to a late diagnosis of HIV. PMID:28186940

The prospects for magnetohydrodynamic stability in advanced tokamak regimes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Manickam, J.; Chance, M.S.; Jardin, S.C.

1994-05-01

Stability analysis of advanced regime tokamaks is presented. Here advanced regimes are defined to include configurations where the ratio of the bootstrap current, [ital I][sub BS], to the total plasma current, [ital I][sub [ital p

Paramedics experiences and expectations concerning advance directives: a prospective, questionnaire-based, bi-centre study.

PubMed

Taghavi, Mahmoud; Simon, Alfred; Kappus, Stefan; Meyer, Nicole; Lassen, Christoph L; Klier, Tobias; Ruppert, David B; Graf, Bernhard M; Hanekop, Gerd G; Wiese, Christoph H R

2012-10-01

Advance directives and palliative crisis cards are means by which palliative care patients can exert their autonomy in end-of-life decisions. To examine paramedics' attitudes towards advance directives and end-of-life care. Questionnaire-based investigation using a self-administered survey instrument. Paramedics of two cities (Hamburg and Goettingen, Germany) were included. Participants were questioned as to (1) their attitudes about advance directives, (2) their clinical experiences in connection with end-of-life situations (e.g. resuscitation), (3) their suggestions in regard to advance directives, 'Do not attempt resuscitation' orders and palliative crisis cards. Questionnaires were returned by 728 paramedics (response rate: 81%). The majority of paramedics (71%) had dealt with advance directives and end-of-life decisions in emergency situations. Most participants (84%) found that cardiopulmonary resuscitation in end-of-life patients is not useful and 75% stated that they would withhold cardiopulmonary resuscitation in the case of legal possibility. Participants also mentioned that more extensive discussion of legal aspects concerning advance directives should be included in paramedic training curricula. They suggested that palliative crisis cards should be integrated into end-of-life care. Decision making in prehospital end-of-life care is a challenge for all paramedics. The present investigation demonstrates that a dialogue bridging emergency medical and palliative care issues is necessary. The paramedics indicated that improved guidelines on end-of-life decisions and the termination of cardiopulmonary resuscitation in palliative care patients may be essential. Participants do not feel adequately trained in end-of-life care and the content of advance directives. Other recent studies have also demonstrated that there is a need for training curricula in end-of-life care for paramedics.

Healthcare professionals' response to cachexia in advanced cancer: a qualitative study.

PubMed

Millar, Claire; Reid, Joanne; Porter, Sam

2013-11-01

To explore healthcare professionals' experience, understanding, and perception of the needs of patients with cachexia in advanced cancer. A qualitative approach based on symbolic interactionism. A regional cancer center in a large teaching hospital in the United Kingdom. 34 healthcare professionals who had experience providing care to patients with cachexia in advanced cancer. Data collection consisted of two phases: focus group and semistructured interviews. Interviews were digitally recorded and transcribed verbatim for analysis. This article reports on findings from the second phase of data collection. Analysis revealed that professional approaches to cachexia were influenced by three overarching and interthinking themes: knowledge, culture, and resources. Healthcare professionals commonly recognized the impact of the syndrome; however, for nonpalliative healthcare professionals, a culture of avoidance and an overreliance on the biomedical model of care had considerable influence on the management of cachexia in patients with advanced cancer. Cachexia management in patients with advanced cancer can be difficult and is directed by a variable combination of the influence of knowledge, culture of the clinical area, and available resources. Distinct differences exist in the management of cachexia among palliative and nonpalliative care professionals. This study presented a multiprofessional perspective on the management of cachexia in patients with advanced cancer and revealed that cachexia is a complex and challenging syndrome that needs to be addressed from a holistic model of care. Cachexia management in patients with advanced cancer is complex and challenging and is directed by a combination of variables. An overreliance on the biomedical model of health and illness occurs in the management of cachexia in patients with advanced cancer. Cachexia needs to be addressed from a holistic model of care to reflect the multidimensional needs of patients and their families.

FAA/NASA International Symposium on Advanced Structural Integrity Methods for Airframe Durability and Damage Tolerance

NASA Technical Reports Server (NTRS)

Harris, Charles E. (Editor)

1994-01-01

International technical experts in durability and damage tolerance of metallic airframe structures were assembled to present and discuss recent research findings and the development of advanced design and analysis methods, structural concepts, and advanced materials. The symposium focused on the dissemination of new knowledge and the peer-review of progress on the development of advanced methodologies. Papers were presented on: structural concepts for enhanced durability, damage tolerance, and maintainability; new metallic alloys and processing technology; fatigue crack initiation and small crack effects; fatigue crack growth models; fracture mechanics failure, criteria for ductile materials; structural mechanics methodology for residual strength and life prediction; development of flight load spectra for design and testing; and advanced approaches to resist corrosion and environmentally assisted fatigue.

Building foundations for the future: the NHS Scotland advanced practice succession planning development pathway.

PubMed

Currie, Kay; Grundy, Maggie

2011-10-01

To highlight implications for managers from the implementation of a national advanced practice succession planning development pathway within Scotland. Internationally, advanced practice posts have often developed in an ad-hoc manner, with little organizational attention to succession planning. Evaluation of a pilot national succession planning development pathway identified mechanisms which facilitate or hamper effective planning for advanced practice roles. A responsive evaluation design incorporating semi-structured questionnaires to pathway participants (n = 15) and semi-structured telephone interviews with case-site pathway participants (n = 7) and their line managers. Managers believed the development pathway was worthwhile; however, there was limited strategic planning to match individuals' development to service need. Practitioners generally perceived managers as interested in their development, although levels of practical support varied. There is concern from both managers and practitioners regarding ongoing funding for advanced practice development. The present evaluation study reiterates the need for organizational commitment to succession planning including robust service needs analysis mechanisms and adequate funding for development processes. Nurse managers are viewed as the 'gatekeepers' to opportunities for developing advanced nurse practitioners; scare resources must be targeted effectively to support succession planning through the development of selected individuals for future advanced practice posts, justified by service need. © 2011 Blackwell Publishing Ltd.

Preoperative therapy in locally advanced esophageal cancer.

PubMed

Garg, Pankaj Kumar; Sharma, Jyoti; Jakhetiya, Ashish; Goel, Aakanksha; Gaur, Manish Kumar

2016-10-21

Esophageal cancer is an aggressive malignancy associated with dismal treatment outcomes. Presence of two distinct histopathological types distinguishes it from other gastrointestinal tract malignancies. Surgery is the cornerstone of treatment in locally advanced esophageal cancer (T2 or greater or node positive); however, a high rate of disease recurrence (systemic and loco-regional) and poor survival justifies a continued search for optimal therapy. Various combinations of multimodality treatment (preoperative/perioperative, or postoperative; radiotherapy, chemotherapy, or chemoradiotherapy) are being explored to lower disease recurrence and improve survival. Preoperative therapy followed by surgery is presently considered the standard of care in resectable locally advanced esophageal cancer as postoperative treatment may not be feasible for all the patients due to the morbidity of esophagectomy and prolonged recovery time limiting the tolerance of patient. There are wide variations in the preoperative therapy practiced across the centres depending upon the institutional practices, availability of facilities and personal experiences. There is paucity of literature to standardize the preoperative therapy. Broadly, chemoradiotherapy is the preferred neo-adjuvant modality in western countries whereas chemotherapy alone is considered optimal in the far East. The present review highlights the significant studies to assist in opting for the best evidence based preoperative therapy (radiotherapy, chemotherapy or chemoradiotherapy) for locally advanced esophageal cancer.

Concept for a Satellite-Based Advanced Air Traffic Management System : Volume 7. System Cost.

DOT National Transportation Integrated Search

1973-02-01

The volume presents estimates of the federal government and user costs for the Satellite-Based Advanced Air Traffic Management System and the supporting rationale. The system configuration is that presented in volumes II and III. The cost estimates a...

Mean curvature model for a quasi-static advancing meniscus: a drop tower test

NASA Astrophysics Data System (ADS)

Chen, Yongkang; Tavan, Noel; Weislogel, Mark

A critical geometric wetting condition resulting in a significant shift of a capillary fluid from one region of a container to another was recently demonstrated during experiments performed aboard the International Space Station (the Capillary Flow Experiments, Vane Gap test units, bulk shift phenomena). Such phenomena are of interest for advanced methods of control for large quantities of liquids aboard spacecraft. The dynamics of the flows are well understood, but analytical models remain qualitative without the correct capillary pressure driving force for the shifting bulk fluid—where one large interface (meniscus) advances while another recedes. To determine this pressure an investigation of the mean curvature of the advancing meniscus is presented which is inspired by earlier studies of receding bulk menisci in non-circular cylindrical containers. The approach is permissible only in the quasi-static limit. It will be shown that the mean curvature of the advancing bulk meniscus is related to that of the receding bulk meniscus, both of which are highly sensitive to container geometry and wetting conditions. The two meniscus curvatures are identical for any control parameter at the critical value identified by the Concus-Finn analysis. However, they differ when the control parameter is below its critical value. Experiments along these lines are well suited for drop towers and comparisons with the analytical predictions implementing the mean curvature model are presented. The validation opens a pathway to the analysis of such flows in containers of great geometric complexity.

Spectral Domain Optical Coherence Tomographic Findings of Bietti Crystalline Dystrophy

PubMed Central

Öner, Ferit Hakan

2014-01-01

We analyzed the OCT features of 24 eyes of 12 patients with Bietti crystalline dystrophy (BCD) with the Heidelberg HRA2-OCT. Seventeen of 24 eyes were in intermediate stage of the disease and seven in advanced stage of the disease at the time of latest OCT examination performed in 2014. Outer retinal tubulations and retinal hyperreflective dots were present in 20 of 24 eyes. The remaining four eyes had advanced disease with very thin retina. Appearance of bright plaque on top of RPE-Bruch membrane was present in all eyes. Choroidal hyperreflective spots were noted in 19 of 24 eyes. The remaining five eyes had advanced disease stage with very thin choroid. Mean central macular thickness was 163.08 μm ± 62.52 for all eyes (170.35 μm ± 56.46 in eyes with intermediate disease and 145.42 μm ± 77.2 in eyes with advanced disease). Mean subfoveal choroidal thickness was 95.37 μm ± 55.93 for the study eyes (116.47 ± 46.92 μm in eyes with intermediate disease and 44.14 μm ± 42.43 in eyes with advanced disease). Choroidal hyperreflective spots were noted in 21 of 24 eyes (87.5%). SD-OCT shows the disease progression in retinal and choroidal layers delicately in eyes with BCD and expands our knowledge about the ongoing disease process. PMID:25505979

Engine technology challenges for a 21st Century High-Speed Civil Transport

NASA Technical Reports Server (NTRS)

Shaw, Robert J.; Gilkey, Samuel; Hines, Richard

1993-01-01

Ongoing NASA-funded studies by Boeing, McDonnell-Douglas, General Electric, and Pratt & Whitney indicate that an opportunity exists for a 21st Century High-Speed Civil Transport (HSCT) to become a major part of the international air transportation system. However, before industry will consider an HSCT product launch and an investment estimated to be over $15 billion for design and certification, major technology advances must be made. An overview of the propulsion-specific technology advances that must be in hand before an HSCT product launch could be considered is presented.

Rett syndrome from bench to bedside: recent advances

PubMed Central

Ehinger, Yann; Matagne, Valerie; Villard, Laurent; Roux, Jean-Christophe

2018-01-01

Rett Syndrome is a severe neurological disorder mainly due to de novo mutations in the methyl-CpG-binding protein 2 gene ( MECP2). Mecp2 is known to play a role in chromatin organization and transcriptional regulation. In this review, we report the latest advances on the molecular function of Mecp2 and the new animal and cellular models developed to better study Rett syndrome. Finally, we present the latest innovative therapeutic approaches, ranging from classical pharmacology to correct symptoms to more innovative approaches intended to cure the pathology. PMID:29636907

Sarcomatoid renal cell carcinoma: Biology and treatment advances.

PubMed

Mouallem, Nemer El; Smith, Steven C; Paul, Asit K

2018-06-01

Sarcomatoid transformation in renal cell carcinoma, so called sacromatoid RCC (sRCC), is associated with an aggressive behavior and a poor prognosis. Current therapeutic approaches are largely ineffective. Recent studies looking into the genomic and molecular characterization of sRCCs have provided insights into the biology and pathogenesis of this entity. These advances in molecular signatures may help development of effective treatment strategies. We herein present a review of recent developments in the pathology, biology, and treatment modalities in sRCC. Copyright © 2017 Elsevier Inc. All rights reserved.

Montessori-based activities for long-term care residents with advanced dementia: effects on engagement and affect.

PubMed

Orsulic-Jeras, S; Judge, K S; Camp, C J

2000-02-01

Sixteen residents in long-term care with advanced dementia (14 women; average age = 88) showed significantly more constructive engagement (defined as motor or verbal behaviors in response to an activity), less passive engagement (defined as passively observing an activity), and more pleasure while participating in Montessori-based programming than in regularly scheduled activities programming. Principles of Montessori-based programming, along with examples of such programming, are presented. Implications of the study and methods for expanding the use of Montessori-based dementia programming are discussed.

Overview of Thoracic Oncology Trials in Cooperative Groups Around the Globe

PubMed Central

Salahudeen, Ameen Abdulla; Patel, Manali I.; Baas, Paul; Curran, Walter J.; Bradley, Jeffrey D.; Gandara, David R.; Goss, Glenwood D.; Mok, Tony S.; Ramalingam, Suresh S.; Vokes, Everett E.; Malik, Shakun M.; Wakelee, Heather A.

2017-01-01

Survival rates of patients with either early and advanced stage non–small-cell lung cancer (NSCLC) have improved with newer systemic therapy and radiation techniques, including combination regimens, targeted therapies, and immunotherapies. The cancer cooperative groups have historically played a critical role in the advancement of NSCLC therapy. Annually, representatives from cooperative groups worldwide convene at the International Lung Cancer Congress (ILCC). In summer 2015, the ILCC reached its 16th anniversary. This article highlights the NSCLC studies presented by participating groups in 2015. PMID:27473736

Window acoustic study for advanced turboprop aircraft

NASA Technical Reports Server (NTRS)

Prydz, R. A.; Balena, F. J.

1984-01-01

An acoustic analysis was performed to establish window designs for advanced turboprop powered aircraft. The window transmission loss requirements were based on A-weighted interior noise goals of 80 and 75 dBA. The analytical results showed that a triple pane window consisting of two glass outer panes and an inner pane of acrylic would provide the required transmission loss and meet the sidewall space limits. Two window test articles were fabricated for laboratory evaluation and verification of the predicted transmission loss. Procedures for performing laboratory tests are presented.

Measurement of the sound absorption coefficient for an advanced undergraduate physics laboratory

NASA Astrophysics Data System (ADS)

Macho-Stadler, E.; Elejalde-García, M. J.

2017-09-01

We present a simple experiment that allows advanced undergraduates to learn the basics of the acoustic properties of materials. The impedance tube-standing wave method is applied to study the normal absorption coefficient of acoustics insulators. The setup includes a tube, a speaker, a microphone, a digital function generator and an oscilloscope, material available in an undergraduate laboratory. Results of the change of the absorption coefficient with the frequency, the sample thickness and the sample density are analysed and compared with those obtained with a commercial system.

Advanced Life Support Water Recycling Technologies Case Studies: Vapor Phase Catalytic Ammonia Removal and Direct Osmotic Concentration

NASA Technical Reports Server (NTRS)

Flynn, Michael

2004-01-01

Design for microgravity has traditionally not been well integrated early on into the development of advanced life support (ALS) technologies. NASA currently has a many ALS technologies that are currently being developed to high technology readiness levels but have not been formally evaluated for microgravity compatibility. Two examples of such technologies are the Vapor Phase Catalytic Ammonia Removal Technology and the Direct Osmotic Concentration Technology. This presentation will cover the design of theses two systems and will identify potential microgravity issues.

Advanced Cancer Patients' Perceptions of Dignity: The Impact of Psychologically Distressing Symptoms and Preparatory Grief.

PubMed

Kostopoulou, Sotiria; Parpa, Efi; Tsilika, Eleni; Katsaragakis, Stylianos; Papazoglou, Irene; Zygogianni, Anna; Galanos, Antonis; Mystakidou, Kyriaki

2018-04-01

The present study assesses the relationship between patient dignity in advanced cancer and the following variables: psychological distress, preparatory grief, and sociodemographic and clinical characteristics. The sample consisted of 120 patients with advanced cancer. The self-administered questionnaires were as follows: the Preparatory Grief in Advanced Cancer Patients (PGAC), the Patient Dignity Inventory-Greek (PDI-Gr), the Greek Schedule for Attitudes toward Hastened Death (G-SAHD), and the Greek version of the Hospital Anxiety and Depression Scale (G-HADS). Moderate to strong statistically significant correlations were found between the 4 subscales of PDI-Gr (psychological distress, body image and role identity, self-esteem, and social support) with G-HADS, G-SAHD, and PGAC ( P < .005), while physical distress and dependency was moderately correlated with depression. Multifactorial analyses showed that preparatory grief, depression, and age influenced psychological distress, while preparatory grief, depression, and performance status influenced body image and role identity. Preparatory grief, psychological distress, and physical symptoms had significant associations with perceptions of dignity among patients with advanced cancer. Clinicians should assess and attend to dignity-distressing factors in the care of patients with advanced cancer.

Space Electrochemical Research and Technology Conference: Abstracts

NASA Technical Reports Server (NTRS)

1989-01-01

The objectives of the conference were to examine current technologies, research efforts, and advanced ideas, and to identify technical barriers which affect the advancement of electrochemical energy storage systems for space applications. Papers were presented and workshops were conducted in four technical areas: advanced concepts, hydrogen-oxygen fuel cells and electrolyzers, the nickel electrode, and advanced rechargeable batteries.

Methodological Challenges in Studies Comparing Prehospital Advanced Life Support with Basic Life Support.

PubMed

Li, Timmy; Jones, Courtney M C; Shah, Manish N; Cushman, Jeremy T; Jusko, Todd A

2017-08-01

Determining the most appropriate level of care for patients in the prehospital setting during medical emergencies is essential. A large body of literature suggests that, compared with Basic Life Support (BLS) care, Advanced Life Support (ALS) care is not associated with increased patient survival or decreased mortality. The purpose of this special report is to synthesize the literature to identify common study design and analytic challenges in research studies that examine the effect of ALS, compared to BLS, on patient outcomes. The challenges discussed in this report include: (1) choice of outcome measure; (2) logistic regression modeling of common outcomes; (3) baseline differences between study groups (confounding); (4) inappropriate statistical adjustment; and (5) inclusion of patients who are no longer at risk for the outcome. These challenges may affect the results of studies, and thus, conclusions of studies regarding the effect of level of prehospital care on patient outcomes should require cautious interpretation. Specific alternatives for avoiding these challenges are presented. Li T , Jones CMC , Shah MN , Cushman JT , Jusko TA . Methodological challenges in studies comparing prehospital Advanced Life Support with Basic Life Support. Prehosp Disaster Med. 2017;32(4):444-450.

How healthcare systems evaluate their advance care planning initiatives: Results from a systematic review.

PubMed

Biondo, Patricia D; Lee, Lydia D; Davison, Sara N; Simon, Jessica E

2016-09-01

Advance care planning initiatives are being implemented across healthcare systems around the world, but how best to evaluate their implementation is unknown. To identify gaps and/or redundancies in current evaluative strategies to help healthcare systems develop future evaluative frameworks for ACP. Systematic review. Peer-reviewed and gray literature searches were conducted till February 2015 to answer: "What methods have healthcare systems used to evaluate implementation of advance care planning initiatives?" A PICOS framework was developed to identify articles describing the implementation and evaluation of a health system-level advance care planning initiative. Outcome measures were mapped onto a conceptual quality indicator framework based on the Institute of Medicine and Donabedian models of healthcare quality. A total of 46 studies met inclusion criteria for analysis. Most articles reported on single parts of a healthcare system (e.g. continuing care). The most common outcome measures pertained to document completion, followed by healthcare resource use. Patient-, family-, or healthcare provider-reported outcomes were less commonly measured. Concordance measures (e.g. dying in place of choice) were reported by only 26% of studies. The conceptual quality indicator framework identified gaps and redundancies in measurement and is presented as a potential foundation from which to develop a comprehensive advance care planning evaluation framework. Document completion is frequently used to evaluate advance care planning program implementation; capturing the quality of care appears to be more difficult. This systematic review provides health system administrators with a comprehensive summary of measures used to evaluate advance care planning and may identify gaps in evaluation within their local context. © The Author(s) 2016.

Cost-utility analysis of an advanced pressure ulcer management protocol followed by trained wound, ostomy, and continence nurses.

PubMed

Kaitani, Toshiko; Nakagami, Gojiro; Iizaka, Shinji; Fukuda, Takashi; Oe, Makoto; Igarashi, Ataru; Mori, Taketoshi; Takemura, Yukie; Mizokami, Yuko; Sugama, Junko; Sanada, Hiromi

2015-01-01

The high prevalence of severe pressure ulcers (PUs) is an important issue that requires to be highlighted in Japan. In a previous study, we devised an advanced PU management protocol to enable early detection of and intervention for deep tissue injury and critical colonization. This protocol was effective for preventing more severe PUs. The present study aimed to compare the cost-effectiveness of the care provided using an advanced PU management protocol, from a medical provider's perspective, implemented by trained wound, ostomy, and continence nurses (WOCNs), with that of conventional care provided by a control group of WOCNs. A Markov model was constructed for a 1-year time horizon to determine the incremental cost-effectiveness ratio of advanced PU management compared with conventional care. The number of quality-adjusted life-years gained, and the cost in Japanese yen (¥) ($US1 = ¥120; 2015) was used as the outcome. Model inputs for clinical probabilities and related costs were based on our previous clinical trial results. Univariate sensitivity analyses were performed. Furthermore, a Bayesian multivariate probability sensitivity analysis was performed using Monte Carlo simulations with advanced PU management. Two different models were created for initial cohort distribution. For both models, the expected effectiveness for the intervention group using advanced PU management techniques was high, with a low expected cost value. The sensitivity analyses suggested that the results were robust. Intervention by WOCNs using advanced PU management techniques was more effective and cost-effective than conventional care. © 2015 by the Wound Healing Society.

Proceedings of the 16th NASA Propagation Experimenters Meeting (NAPEX 16) and the Advanced Communications Technology Satellite (ACTS) Propagation Studies Miniworkshop

NASA Technical Reports Server (NTRS)

Davarian, Faramaz (Editor)

1992-01-01

The NASA Propagation Experimenters Meeting (NAPEX), supported by the NASA Propagation Program, is convened annually to discuss studies made on radio wave propagation by investigators from domestic and international organizations. NAPEX 16 was held on May 29, 1992 in Houston, Texas. The meeting was organized into two technical sessions. The first session was dedicated to slant path propagation studies and measurements. The second session focused on Olympus propagation measurements and results. Following NAPEX 16, the Advanced Communications Technology Satellite (ACTS) Miniworkshop was held to review ACTS propagation activities with emphasis on ACTS hardware development and experiment planning. Eight technical papers were presented by contributors from government agencies, private industry, and university research establishments.

Assembling evidence for identifying reservoirs of infection.

PubMed

Viana, Mafalda; Mancy, Rebecca; Biek, Roman; Cleaveland, Sarah; Cross, Paul C; Lloyd-Smith, James O; Haydon, Daniel T

2014-05-01

Many pathogens persist in multihost systems, making the identification of infection reservoirs crucial for devising effective interventions. Here, we present a conceptual framework for classifying patterns of incidence and prevalence, and review recent scientific advances that allow us to study and manage reservoirs simultaneously. We argue that interventions can have a crucial role in enriching our mechanistic understanding of how reservoirs function and should be embedded as quasi-experimental studies in adaptive management frameworks. Single approaches to the study of reservoirs are unlikely to generate conclusive insights whereas the formal integration of data and methodologies, involving interventions, pathogen genetics, and contemporary surveillance techniques, promises to open up new opportunities to advance understanding of complex multihost systems. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

Does the incidence of pulmonary embolism increase during pregnancy?

PubMed

Howard, Courtney; Howard, Patricia Kunz

2015-01-01

A review of recent evidence with translation to practice for the advanced practice nurse role is presented using a case study module for "Systematic Review and Meta-Analysis of Pregnant Patients Investigated for Suspected Pulmonary Embolism in the Emergency Department." The study results showed that there were 25,339 patients evaluated for pulmonary embolism in an emergency department included in the 17 study articles, 2,636 had venous thromboembolism (VTE; 13%; 95% CI [10, 17]), and 506 were pregnant and underwent diagnostic chest imaging (2%; 95% CI [1.5, 2.6]). These data suggest that pregnancy does not appear to increase the incidence of a VTE-positive diagnosis. The implications and clinical relevance of these findings for advanced practice nurses are discussed highlighting best evidence.

Study of repeater technology for advanced multifunctional communications satellites

NASA Technical Reports Server (NTRS)

1972-01-01

Investigations are presented concerning design concepts and implementation approaches for the satellite communication repeater subsystems of advanced multifunctional satellites. In such systems the important concepts are the use of multiple antenna beams, repeater switching (routing), and efficient spectrum utilization through frequency reuse. An information base on these techniques was developed and tradeoff analyses were made of repeater design concepts, with the work design taken in a broad sense to include modulation beam coverage patterns. There were five major areas of study: requirements analysis and processing; study of interbeam interference in multibeam systems; characterization of multiple-beam switching repeaters; estimation of repeater weight and power for a number of alternatives; and tradeoff analyses based on these weight and power data.

Rocket Ejector Studies for Application to RBCC Engines: An Integrated Experimental/CFD Approach

NASA Technical Reports Server (NTRS)

Pal, S.; Merkle, C. L.; Anderson, W. E.; Santoro, R. J.

1997-01-01

Recent interest in low cost, reliable access to space has generated increased interest in advanced technology approaches to space transportation systems. A key to the success of such programs lies in the development of advanced propulsion systems capable of achieving the performance and operations goals required for the next generation of space vehicles. One extremely promising approach involves the combination of rocket and air- breathing engines into a rocket-based combined-cycle engine (RBCC). A key element of that engine is the rocket ejector which is utilized in the zero to Mach two operating regime. Studies of RBCC engine concepts are not new and studies dating back thirty years are well documented in the literature. However, studies focused on the rocket ejector mode of the RBCC cycle are lacking. The present investigation utilizes an integrated experimental and computation fluid dynamics (CFD) approach to examine critical rocket ejector performance issues. In particular, the development of a predictive methodology capable of performance prediction is a key objective in order to analyze thermal choking and its control, primary/secondary pressure matching considerations, and effects of nozzle expansion ratio. To achieve this objective, the present study emphasizes obtaining new data using advanced optical diagnostics such as Raman spectroscopy and CFD techniques to investigate mixing in the rocket ejector mode. A new research facility for the study of the rocket ejector mode is described along with the diagnostic approaches to be used. The CFD modeling approach is also described along with preliminary CFD predictions obtained to date.

Intercultural Learning on Short-Term Sojourns

ERIC Educational Resources Information Center

Jackson, Jane

2009-01-01

This paper presents an ethnographic case study of advanced second language (L2) students from Hong Kong who took part in a short-term sojourn in England after 14 weeks of preparation. While abroad, they lived with a host family, took literary/cultural studies courses, visited cultural sites, participated in debriefing sessions, and conducted…

Listening to Children: Exploring Intuitive Strategies and Interactive Methods in a Study of Children's Special Places

ERIC Educational Resources Information Center

Green, Carie

2012-01-01

Stemming from the UNCRC, childhood researchers have proposed a variety of methodological strategies for upholding children's rights and understanding their perspectives. This paper aims to advance the conversation on engaging children's perspectives by presenting data collection methods used in a qualitative study exploring children's special…

Achievement Goals, Learning Strategies and Instrumental Performance

ERIC Educational Resources Information Center

Nielsen, Siw Graabraek

2008-01-01

The current study is a survey of the achievement goals of music students and the manner in which their strategies and instrumental performance relate to these goals. In the context of advanced instrumental learning, the rationale for the present study was to contribute to the literature on motivation in music students, and thereby, help teachers…

A Case for Qualitative Research in the Social Studies.

ERIC Educational Resources Information Center

Parsons, Jim; And Others

As examples of the qualitative research attitude, six research papers, each of which addresses a serious educational question in a thoughtful and rigorous manner, are presented. The first paper argues for the advancement of a qualitative research attitude in social studies, for such an attitude is consonant with the purposes of a reflective,…

A Study of Brownian Motion Using Light Scattering

ERIC Educational Resources Information Center

Clark, Noel A.; And Others

1970-01-01

Presents an advanced laboratory experiment and lecture demonstration by which the intensity spectrum of light scattered by a suspension of particles in a fluid can be studied. From this spectrum, it is possible to obtain quantitative information about the motion of the particles, including an accurate determination of their diffusion constant.…

Orbit Transfer Vehicle (OTV) engine phase A study, extension 1. Volume 3: Study cost estimates

NASA Technical Reports Server (NTRS)

Christensen, K. L.

1980-01-01

Program cost and planning data based on 1980 technology and shown in 1979 dollars for a 20K lb Thrust Staged Combustion Cycle Engine are presented. These data were compared with those for the Advanced Expander Cycle Engine at 10K lb and 20K lb thrust levels.

Teaching with Technology in Higher Education: Understanding Conceptual Change and Development in Practice

ERIC Educational Resources Information Center

Englund, Claire; Olofsson, Anders D.; Price, Linda

2017-01-01

Research indicates that teachers' conceptions of and approaches to teaching with technology are central for the successful imple-mentation of educational technologies in higher education. This study advances this premise. We present a 10-year longitudinal study examining teachers' conceptions of and approaches to teaching and learning with…

Developmental Trajectories of Conduct Problems and Hyperactivity from Ages 2 to 10

ERIC Educational Resources Information Center

Shaw, Daniel S.; Lacourse, Eric; Nagin, Daniel S.

2005-01-01

Background: Conduct problems (CP) and hyperactivity/attention problems (HAP) are thought to covary with regularity, yet few studies have examined their co-occurrence or risk factors that discriminate their trajectories beginning in early childhood. Method: The present study sought to advance our understanding of this issue by examining separate…

Advancing Scientific Reasoning in Upper Elementary Classrooms: Direct Instruction versus Task Structuring

ERIC Educational Resources Information Center

Lazonder, Ard W.; Wiskerke-Drost, Sjanou

2015-01-01

Several studies found that direct instruction and task structuring can effectively promote children's ability to design unconfounded experiments. The present study examined whether the impact of these interventions extends to other scientific reasoning skills by comparing the inquiry activities of 55 fifth-graders randomly assigned to one of…

Adult Second Language Learning of Spanish Vowels

ERIC Educational Resources Information Center

Cobb, Katherine; Simonet, Miquel

2015-01-01

The present study reports on the findings of a cross-sectional acoustic study of the production of Spanish vowels by three different groups of speakers: 1) native Spanish speakers; 2) native English intermediate learners of Spanish; and 3) native English advanced learners of Spanish. In particular, we examined the production of the five Spanish…

Associate Degree or Advanced Diploma? A Case Study. Occasional Paper

ERIC Educational Resources Information Center

Karmel, Tom; Lu, Tham

2012-01-01

This paper presents a case study in which the authors attempted to understand the impact, on student choice, of reforms in tertiary education in Australia, namely, a shift towards a demand-driven system and the blurring of the distinction between vocational education and training (VET) and higher education. The authors compared the advanced…

College Students' Interpretation of Research Reports on Group Differences: The Tall-Tale Effect

ERIC Educational Resources Information Center

Hogan, Thomas P.; Zaboski, Brian A.; Perry, Tiffany R.

2015-01-01

How does the student untrained in advanced statistics interpret results of research that reports a group difference? In two studies, statistically untrained college students were presented with abstracts or professional associations' reports and asked for estimates of scores obtained by the original participants in the studies. These estimates…

Adolescents' Cyber Aggression Perpetration and Cyber Victimization: The Longitudinal Associations with School Functioning

ERIC Educational Resources Information Center

Wright, Michelle F.

2015-01-01

The literature on cyber aggression is advancing, revealing many risk factors associated with the involvement in these behaviors. Academic correlates, particularly academic performance, have received some attention, with few studies utilizing longitudinal designs. The present study examined these associations among 673 8th graders (51% female) from…

A Cross-Cultural Comparison of Anxiety among College Students

ERIC Educational Resources Information Center

Baloglu, Mustafa; Abbasi, Amir; Masten, William G.

2007-01-01

A number of studies have continued to investigate cross-cultural differences in anxiety. However, the cross-national research on anxiety is still far less advanced than other psychological constructs such as schizophrenia or depression. Thus, the purpose of the present study was to compare and contrast the levels of anxiety experienced by …

Performance of steel girders repaired with advanced composite sheets in a corrosive environment.

DOT National Transportation Integrated Search

2017-01-01

This report presents a two-phase research program studying i) galvanic current influencing deterioration of carbon fiber reinforced polymer (CFRP) sheets bonded to a steel substrate and ii) electrochemical reaction for steel beams strengthened with C...

7 CFR 4288.120 - Enrollment.

Code of Federal Regulations, 2013 CFR

2013-01-01

... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE PAYMENT PROGRAMS Advanced Biofuel Payment Program General... the Program is presented in this section. Advanced biofuel producers who expect to produce eligible.... (a) Enrollment. To enroll in the Program, an advanced biofuel producer must submit to the Agency a...

7 CFR 4288.120 - Enrollment.

Code of Federal Regulations, 2012 CFR

2012-01-01

... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE PAYMENT PROGRAMS Advanced Biofuel Payment Program General... the Program is presented in this section. Advanced biofuel producers who expect to produce eligible.... (a) Enrollment. To enroll in the Program, an advanced biofuel producer must submit to the Agency a...

Investigation of Unsteady Flow Interaction Between an Ultra-Compact Inlet and a Transonic Fan

NASA Technical Reports Server (NTRS)

Hah, Chunill; Rabe, Douglas; Scribben, Angie

2015-01-01

In the present study, unsteady flow interaction between an ultra-compact inlet and a transonic fan stage is investigated. Future combat aircraft require ultra-compact inlet ducts as part of an integrated, advanced propulsion system to improve air vehicle capability and effectiveness to meet future mission needs. The main purpose of the study is to advance the current understanding of the flow interaction between two different ultra-compact inlets and a transonic fan for future design applications. Both URANS and LES approaches are used to calculate the unsteady flow field and are compared with the available measured data. The present study indicates that stall inception is mildly affected by the distortion pattern generated by the inlet with the current test set-up. The numerical study indicates that the inlet distortion pattern decays significantly before it reaches the fan face for the current configuration. Numerical results with a shorter distance between the inlet and fan show that counter-rotating vortices near the rotor tip due to the serpentine diffuser affects fan characteristics significantly.

Functional Requirements for Onboard Management of Space Shuttle Consumables. Volume 2

NASA Technical Reports Server (NTRS)

Graf, P. J.; Herwig, H. A.; Neel, L. W.

1973-01-01

This report documents the results of the study "Functional Requirements for Onboard Management of Space Shuttle Consumables." The study was conducted for the Mission Planning and Analysis Division of the NASA Lyndon B. Johnson Space Center, Houston, Texas, between 3 July 1972 and 16 November 1973. The overall study program objective was two-fold. The first objective was to define a generalized consumable management concept which is applicable to advanced spacecraft. The second objective was to develop a specific consumables management concept for the Space Shuttle vehicle and to generate the functional requirements for the onboard portion of that concept. Consumables management is the process of controlling or influencing the usage of expendable materials involved in vehicle subsystem operation. The report consists of two volumes. Volume I presents a description of the study activities related to general approaches for developing consumable management, concepts for advanced spacecraft applications, and functional requirements for a Shuttle consumables management concept. Volume II presents a detailed description of the onboard consumables management concept proposed for use on the Space Shuttle.

Time-domain hybrid method for simulating large amplitude motions of ships advancing in waves

NASA Astrophysics Data System (ADS)

Liu, Shukui; Papanikolaou, Apostolos D.

2011-03-01

Typical results obtained by a newly developed, nonlinear time domain hybrid method for simulating large amplitude motions of ships advancing with constant forward speed in waves are presented. The method is hybrid in the way of combining a time-domain transient Green function method and a Rankine source method. The present approach employs a simple double integration algorithm with respect to time to simulate the free-surface boundary condition. During the simulation, the diffraction and radiation forces are computed by pressure integration over the mean wetted surface, whereas the incident wave and hydrostatic restoring forces/moments are calculated on the instantaneously wetted surface of the hull. Typical numerical results of application of the method to the seakeeping performance of a standard containership, namely the ITTC S175, are herein presented. Comparisons have been made between the results from the present method, the frequency domain 3D panel method (NEWDRIFT) of NTUA-SDL and available experimental data and good agreement has been observed for all studied cases between the results of the present method and comparable other data.

Space Electrochemical Research and Technology (SERT)

NASA Technical Reports Server (NTRS)

1987-01-01

The conference provided a forum to assess critical needs and technologies for the NASA electrochemical energy conversion and storage program. It was aimed at providing guidance to NASA on the appropriate direction and emphasis of that program. A series of related overviews were presented in the areas of NASA advanced mission models (space stations, low and geosynchronous Earth orbit missions, planetary missions, and space transportation). Papers were presented and workshops conducted in a variety of technical areas, including advanced rechargeables, advanced concepts, critical physical electrochemical issues, and modeling.

Analysis of the Association Between Electrocardiographic P-wave Characteristics and Atrial Fibrillation in the REGICOR Study.

PubMed

Massó-van Roessel, Albert; Escobar-Robledo, Luis Alberto; Dégano, Irene R; Grau, María; Sala, Joan; Ramos, Rafel; Marrugat, Jaume; Bayés de Luna, Antoni; Elosua, Roberto

2017-10-01

Atrial fibrillation (AF) is the most common clinically significant cardiac arrhythmia. P-wave duration and interatrial blocks (IAB) have been reported to be associated with AF. Our aim was to determine the individual and combined association of P-wave duration and advanced IAB morphology with AF. We designed an age-, sex-, and survey-matched case-control study nested in a population-based cohort (REGICOR: REgistre GIroní del COR). Two different surveys recruited a total of 9380 participants from 1999 to 2005; all participants were invited to a second examination between 2009 and 2013. For the present study, we selected participants aged 25 to 79 years with follow-up through the end of the study. All electrocardiograms were analyzed by 2 observers to determine P-wave duration and morphology (normal, partial, or advanced IAB). The median follow-up was 7.12 years. Eighty participants presented with AF, had a legible baseline electrocardiogram, and were included in the study, along with 160 controls. P-wave duration and the presence of partial or advanced IAB were associated with AF. When P-wave duration and morphology were considered together, only P-wave duration (≥ 110 milliseconds) showed an independent and strong association with AF. The odds ratio for AF of P-wave duration between 110-119, 120-129 and ≥ 130 milliseconds vs < 110 milliseconds were 5.33; 95%CI, 1.74-16.33, 5.08; 95%CI, 1.73-14.90 and 5.44; 95%CI, 1.95-15.15, respectively. A P-wave longer than 110 milliseconds increases the risk of AF. Advanced IAB morphology did not seem to provide an additional AF risk beyond that of P-wave duration. Copyright © 2017 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved.

Major clinical research advances in gynecologic cancer in 2014.

PubMed

Suh, Dong Hoon; Lee, Kyung Hun; Kim, Kidong; Kang, Sokbom; Kim, Jae Weon

2015-04-01

In 2014, 9 topics were selected as major advances in clinical research for gynecologic oncology: 2 each in cervical and corpus cancer, 4 in ovarian cancer, and 1 in breast cancer. For cervical cancer, several therapeutic agents showed viable antitumor clinical response in recurrent and metastatic disease: bevacizumab, cediranib, and immunotherapies including human papillomavirus (HPV)-tumor infiltrating lymphocytes and Z-100. The HPV test received FDA approval as the primary screening tool of cervical cancer in women aged 25 and older, based on the results of the ATHENA trial, which suggested that the HPV test was a more sensitive and efficient strategy for cervical cancer screening than methods based solely on cytology. For corpus cancers, results of a phase III Gynecologic Oncology Group (GOG) 249 study of early-stage endometrial cancer with high-intermediate risk factors are followed by the controversial topic of uterine power morcellation in minimally invasive gynecologic surgery. Promising results of phase II studies regarding the effectiveness of olaparib in various ovarian cancer settings are summarized. After a brief review of results from a phase III study on pazopanib maintenance therapy in advanced ovarian cancer, 2 outstanding 2014 ASCO presentations cover the topic of using molecular subtypes in predicting response to bevacizumab. A review of the use of opportunistic bilateral salpingectomy as an ovarian cancer preventive strategy in the general population is presented. Two remarkable studies that discussed the effectiveness of adjuvant ovarian suppression in premenopausal early breast cancer have been selected as the last topics covered in this review.

Improving the Cooperation Rate of Older Adults and Their Caregivers in Research Surveys.

PubMed

Green, Ohad; Ayalon, Liat

2015-01-01

Recruiting older adults, their family members and their home care workers as participants in research studies is particularly complicated. This might be due to medical or cognitive problems of the older adult as well as the high workload and shortage of time experienced by caregivers. The present study compared the contribution of two different versions of an advanced letter followed by two different versions of a recruitment phone call to the cooperation rate of older adults, family caregivers and home care workers in a face-to-face survey. A quasi-experimental design was used to compare the contribution of the different types of appeal. A total of 2,014 caregiving units (composed of an older adult, a family member and a home care worker) were randomly sampled from a list of Israeli long-term care insurance beneficiaries. 74.32% of the sampled caregiving units were eligible to participate in the study. The first group of participants received formal and succinctly phrased written and oral appeals - an advanced letter followed by a recruitment phone call. The second group of participants received the original formal and succinctly phrased advanced letter, but a revised recruitment phone call that included a more personal approach, the provision of broader information about the study and the avoidance of words with a possible negative connotation. The third group of participants received both a revised advanced letter and a revised recruitment phone call. Using the succinctly phrased written and oral appeals, we had a cooperation rate of about 50% for the entire caregiving unit. Using a revised advanced letter and a revised recruitment phone call yielded an increase of 20-25% in the cooperation rate for the entire caregiving unit. Using the revised recruitment phone call and the original advanced letter yielded an increase in the cooperation rate only among migrant home care workers. This study showed that by changing the format of appeal we can increase the cooperation rate of older adults and their caregivers in a research survey. This study also pointed out the importance of the advanced letter. © 2014 S. Karger AG, Basel.

An overview of the outcomes and impact of specialist and advanced nursing and midwifery practice, on quality of care, cost and access to services: A narrative review.

PubMed

Casey, Mary; O'Connor, Laserina; Cashin, Andrew; Smith, Rita; O'Brien, Denise; Nicholson, Emma; O'Leary, Denise; Fealy, Gerard; McNamara, Martin; Glasgow, Mary Ellen; Stokes, Diarmuid; Egan, Claire

2017-09-01

This paper presents the results of a systematic rapid review and narrative synthesis of the literature of the outcomes and impact of specialist and advanced nursing and midwifery practice regarding quality of care, cost and access to services. A rapid review was undertaken of the relevant national and international literature, regulatory and policy documents relating to the establishment and definition of nurses' and midwives' specialist and advanced practice roles. A search of the Cumulative Index to the Nursing and Allied Health Literature (CINAHL), PubMed (MEDLINE) was undertaken from 2012 to 2015. The study also included primary data collection on the perceived impact of specialist and advanced practice nursing and midwifery roles and enablers and barriers to these roles using semi-structured interviews. These are not included in this paper. To facilitate a systematic approach to searching the literature, the PICO framework, was adapted. The database search yielded 437 articles relevant to the analysis of specialist and advanced practice in relation to quality care, cost and access to services with additional articles added in a manual review of reference lists. In the final review a total of 86 articles were included as they fulfilled the eligibility criteria. The evidence presented in the 86 articles indicates that nursing and midwifery practitioners continue to be under-utilised despite the evidence that greater reliance on advanced nurse practitioners could improve accessibility of primary care services while also saving on cost. Results point to continued difficulties associated with accurate measurement of the impact of these roles on patient outcomes. This review demonstrates that there is a need for robust measurement of the impact of these roles on patient outcomes. Copyright © 2017 Elsevier Ltd. All rights reserved.

Advancing automation and robotics technology for the Space Station Freedom and for the U.S. Economy

NASA Technical Reports Server (NTRS)

1991-01-01

In April 1985, as required by Public Law 98-371, the NASA Advanced Technology Advisory Committee (ATAC) reported to Congress the results of its studies on advanced automation and robotics technology for use on Space Station Freedom. This material was documented in the initial report (NASA Technical Memorandum 87566). A further requirement of the law was that ATAC follow NASA's progress in this area and report to Congress semiannually. This report is the thirteenth in a series of progress updates and covers the period between 14 Feb. - 15 Aug. 1991. The progress made by Levels 1, 2, and 3 of the Space Station Freedom in developing and applying advanced automation and robotics technology is described. Emphasis was placed upon the Space Station Freedom Program responses to specific recommendations made in ATAC Progress Report 12, and issues of A&R implementation into Ground Mission Operations and A&R enhancement of science productivity. Assessments are presented for these and other areas as they apply to the advancement of automation and robotics technology for Space Station Freedom.

Advancing automation and robotics technology for the Space Station Freedom and for the U.S. economy

NASA Technical Reports Server (NTRS)

1993-01-01

In April 1985, as required by Public Law 98-371, the NASA Advanced Technology Advisory Committee (ATAC) reported to Congress the results of its studies on advanced automation and robotics technology for use on Space Station Freedom. This material was documented in the initial report (NASA Technical Memorandum 87566). A further requirement of the law was that ATAC follow NASA's progress in this area and report to Congress semiannually. This report is the sixteenth in a series of progress updates and covers the period between 15 Sep. 1992 - 16 Mar. 1993. The report describes the progress made by Levels 1, 2, and 3 of the Space Station Freedom in developing and applying advanced automation and robotics technology. Emphasis was placed upon the Space Station Freedom Program responses to specific recommendations made in ATAC Progress Report 15; and includes a status review of Space Station Freedom Launch Processing facilities at Kennedy Space Center. Assessments are presented for these and other areas as they apply to the advancement of automation and robotics technology for Space Station Freedom.

Advanced techniques in placental biology -- workshop report.

PubMed

Nelson, D M; Sadovsky, Y; Robinson, J M; Croy, B A; Rice, G; Kniss, D A

2006-04-01

Major advances in placental biology have been realized as new technologies have been developed and existing methods have been refined in many areas of biological research. Classical anatomy and whole-organ physiology tools once used to analyze placental structure and function have been supplanted by more sophisticated techniques adapted from molecular biology, proteomics, and computational biology and bioinformatics. In addition, significant refinements in morphological study of the placenta and its constituent cell types have improved our ability to assess form and function in highly integrated manner. To offer an overview of modern technologies used by investigators to study the placenta, this workshop: Advanced techniques in placental biology, assembled experts who discussed fundamental principles and real time examples of four separate methodologies. Y. Sadovsky presented the principles of microRNA function as an endogenous mechanism of gene regulation. J. Robinson demonstrated the utility of correlative microscopy in which light-level and transmission electron microscopy are combined to provide cellular and subcellular views of placental cells. A. Croy provided a lecture on the use of microdissection techniques which are invaluable for isolating very small subsets of cell types for molecular analysis. Finally, G. Rice presented an overview methods on profiling of complex protein mixtures within tissue and/or fluid samples that, when refined, will offer databases that will underpin a systems approach to modern trophoblast biology.

Integrating developed and developing world knowledge into global discussions and strategies for sustainability. 1. Science and technology.

PubMed

Mihelcic, James R; Zimmerman, Julie B; Ramaswami, Anu

2007-05-15

Sustainable development in both the developed and developing world has the common fundamental themes of advancing economic and social prosperity while protecting and restoring natural systems. While many recent efforts have been undertaken to transfer knowledge from the developed to the developing world to achieve a more sustainable future, indigenous knowledge that often originates in developing nations also can contribute significantly to this global dialogue. Selected case studies are presented to describe important knowledge, methodologies, techniques, principles, and practices for sustainable development emerging from developing countries in two critical challenge areas to sustainability: water and energy. These, with additional analysis and quantification, can be adapted and expanded for transfer throughout the developed and developing world in advancing sustainability. A common theme in all of the case studies presented is the integration of natural processes and material flows into the anthropogenic system. Some of these techniques, originating in rural settings, have recently been adapted for use in cities, which is especially important as the global trend of urban population growth accelerates. Innovations in science and technology, specifically applied to two critical issues of today, water and energy, are expected to fundamentally shift the type and efficiency of energy and materials utilized to advance prosperity while protecting and restoring natural systems.

Time-efficient simulations of tight-binding electronic structures with Intel Xeon PhiTM many-core processors

NASA Astrophysics Data System (ADS)

Ryu, Hoon; Jeong, Yosang; Kang, Ji-Hoon; Cho, Kyu Nam

2016-12-01

Modelling of multi-million atomic semiconductor structures is important as it not only predicts properties of physically realizable novel materials, but can accelerate advanced device designs. This work elaborates a new Technology-Computer-Aided-Design (TCAD) tool for nanoelectronics modelling, which uses a sp3d5s∗ tight-binding approach to describe multi-million atomic structures, and simulate electronic structures with high performance computing (HPC), including atomic effects such as alloy and dopant disorders. Being named as Quantum simulation tool for Advanced Nanoscale Devices (Q-AND), the tool shows nice scalability on traditional multi-core HPC clusters implying the strong capability of large-scale electronic structure simulations, particularly with remarkable performance enhancement on latest clusters of Intel Xeon PhiTM coprocessors. A review of the recent modelling study conducted to understand an experimental work of highly phosphorus-doped silicon nanowires, is presented to demonstrate the utility of Q-AND. Having been developed via Intel Parallel Computing Center project, Q-AND will be open to public to establish a sound framework of nanoelectronics modelling with advanced HPC clusters of a many-core base. With details of the development methodology and exemplary study of dopant electronics, this work will present a practical guideline for TCAD development to researchers in the field of computational nanoelectronics.