Power Systems for Future Missions: Appendices A-L

NASA Technical Reports Server (NTRS)

Gill, S. P.; Frye, P. E.; Littman, Franklin D.; Meisl, C. J.

1994-01-01

Selection of power system technology for space applications is typically based on mass, readiness of a particular technology to meet specific mission requirements, and life cycle costs (LCC). The LCC is typically used as a discriminator between competing technologies for a single mission application. All other future applications for a given technology are usually ignored. As a result, development cost of a technology becomes a dominant factor in the LCC comparison. Therefore, it is common for technologies such as DIPS and LMR-CBC to be potentially applicable to a wide range of missions and still lose out in the initial LCC comparison due to high development costs. This collection of appendices (A through L) contains the following power systems technology plans: CBC DIPS Technology Roadmap; PEM PFC Technology Roadmap; NAS Battery Technology Roadmap; PV/RFC Power System Technology Roadmap; PV/NAS Battery Technology Roadmap; Thermionic Reactor Power System Technology Roadmap; SP-100 Power System Technology Roadmap; Dynamic SP-100 Power System Technology Roadmap; Near-Term Solar Dynamic Power System Technology Roadmap; Advanced Solar Dynamic Power System Technology Roadmap; Advanced Stirling Cycle Dynamic Isotope Power System Technology Roadmap; and the ESPPRS (Evolutionary Space Power and Propulsion Requirements System) User's Guide.

Transformational Spaceport and Range Capabilities Roadmap Interim Review to National Research Council External Review Panel

NASA Technical Reports Server (NTRS)

Poniatowski, Karen

2005-01-01

Contents include the following: Overview/Introduction. Roadmap Approach/Considerations. Roadmap Timeline/Spirals. Requirements Development. Spaceport/Range Capabilities. Mixed Range Architecture. User Requirements/Customer Considerations. Manifest Considerations. Emerging Launch User Requirements. Capability Breakdown Structure/Assessment. Roadmap Team Observations. Transformational Range Test Concept. Roadmap Team Conclusions. Next Steps.

National Research Council Dialogue to Assess Progress on NASA's Title of CRM Capability Roadmap Development: General Background and Introduction

NASA Technical Reports Server (NTRS)

Crooke, Julie A.

2005-01-01

Contents include the following: General Background and Introduction of Capability Roadmaps "Title." Agency Objective. Strategic Planning Transformation. Advanced Planning Organizational Roles. Public Involvement in Strategic Planning. Strategic Roadmaps and Schedule. Capability Roadmaps and Schedule. Purpose of NRC Review. Capability Roadmap Development (Progress to Date).

National Research Council Dialogue to Assess Progress on NASA's Human Health & Support Systems Capability Roadmap Development: General Background and Introduction

NASA Technical Reports Server (NTRS)

Aikins, Jan

2005-01-01

Contents include the following: General Background and Introduction of Capability Roadmaps. Agency Objective. Strategic Planning Transformation. Advanced Planning Organizational Roles. Public Involvement in Strategic Planning. Strategic Roadmaps and Schedule. Capability Roadmaps and Schedule. Purpose of NRC Review. Capability Roadmap Development (Progress to Date).

Rare Disease Roadmap: Navigating the challenges and barriers to deliver improved outcomes for patients living with a Rare Disease

USDA-ARS?s Scientific Manuscript database

Rare Disease registries have now been recognized as a global priority for progress in monitoring, documenting natural course, preventing and treating rare diseases. However, a disease registry is only one element of Rare Disease translational research. Here, we outline what we believe are ten key co...

National Research Council Dialogue to Assess Progress on NASA's Advanced Modeling, Simulation and Analysis Capability and Systems Engineering Capability Roadmap Development

NASA Technical Reports Server (NTRS)

Aikins, Jan

2005-01-01

Contents include the following: General Background and Introduction of Capability Roadmaps. Agency Objective. Strategic Planning Transformation. Advanced Planning Organizational Roles. Public Involvement in Strategic Planning. Strategic Roadmaps and Schedule. Capability Roadmaps and Schedule. Purpose of NRC Review. Capability Roadmap Development (Progress to Date).

NASA's New Thermal Management Systems Roadmap; Whats in it, What it Means

NASA Technical Reports Server (NTRS)

Swanson, Ted

2016-01-01

In July of 2015 NASA publically released a new set of Technology Area Roadmaps that will be used to help guide future NASA-funded technology development efforts. One of these was the Thermal Management Systems Roadmap, often identified as TA14. This Roadmap identifies the time sequencing and interdependencies of high priority, advanced thermal control technology for the next 5 to 20 years. Available funding limits the development of new technology. The Roadmaps are the first step in the process of prioritizing HQ-supported technology funding. The 2015 Roadmaps are focused on planned mission architectures and needs, as identified in the NRC-led science Decadals and HEOMD's Design Reference Missions. Additionally, the 2015 Roadmaps focus on "applied " R&D as opposed to more basic research. The NASA Mission Directorates were all closely involved in development of 2015 Roadmaps, and an extensive external review was also conducted. This talk will discuss the Technology Roadmaps in general, and then focus on the specific technologies identified for TA 14, Thermal Management Systems.

A roadmap for improving the representation of photosynthesis in Earth system models.

PubMed

Rogers, Alistair; Medlyn, Belinda E; Dukes, Jeffrey S; Bonan, Gordon; von Caemmerer, Susanne; Dietze, Michael C; Kattge, Jens; Leakey, Andrew D B; Mercado, Lina M; Niinemets, Ülo; Prentice, I Colin; Serbin, Shawn P; Sitch, Stephen; Way, Danielle A; Zaehle, Sönke

2017-01-01

Accurate representation of photosynthesis in terrestrial biosphere models (TBMs) is essential for robust projections of global change. However, current representations vary markedly between TBMs, contributing uncertainty to projections of global carbon fluxes. Here we compared the representation of photosynthesis in seven TBMs by examining leaf and canopy level responses of photosynthetic CO 2 assimilation (A) to key environmental variables: light, temperature, CO 2 concentration, vapor pressure deficit and soil water content. We identified research areas where limited process knowledge prevents inclusion of physiological phenomena in current TBMs and research areas where data are urgently needed for model parameterization or evaluation. We provide a roadmap for new science needed to improve the representation of photosynthesis in the next generation of terrestrial biosphere and Earth system models. No claim to original US Government works New Phytologist © 2016 New Phytologist Trust.

High Energy Power and Propulsion Capability Roadmap: General Background and Introduction

NASA Technical Reports Server (NTRS)

Bankston, Perry

2005-01-01

Agency objective are: Strategic Planning Transformation. Advanced Planning Organizational Roles. Public Involvement in Strategic Planning. Strategic Roadmaps and Schedule Capability Roadmaps and Schedule. Purpose of NRC Review. Capability Roadmap Development (Progress to Date).

National Research Council Dialogue to Assess Progress on NASA's Transformational Spaceport and Range Technologies Capability Roadmap Development: General Background and Introduction

NASA Technical Reports Server (NTRS)

Skelly, Darin M.

2005-01-01

Viewgraphs on the National Research Council's diaglog to assess progress on NASA's transformational spaceport and range technologies capability roadmap development is presented. The topics include: 1) Agency Goals and Objectives; 2) Strategic Planning Transformation; 3) Advanced Planning Organizational Roles; 4) Public Involvement in Strategic Planning; 5) Strategic Roadmaps; 6) Strategic Roadmaps Schedule; 7) Capability Roadmaps; 8) Capability Charter; 9) Process for Team Selection; 10) Capability Roadmap Development Schedule Overview; 11) Purpose of NRC Review; 12) Technology Readiness Levels; 13) Capability Readiness Levels; 14) Crosswalk Matrix Trans Spaceport & Range; 15) Example linkage to other roadmaps; 16) Capability Readiness Levels Defined; and 17) Crosswalk Matrix Ratings Work In-progress.

Advanced Telescopes and Observatories and Scientific Instruments and Sensors Capability Roadmaps: General Background and Introduction

NASA Technical Reports Server (NTRS)

Coulter, Dan; Bankston, Perry

2005-01-01

Agency objective are: Strategic Planning Transformation. Advanced Planning Organizational Roles. Public Involvement in Strategic Planning. Strategic Roadmaps and Schedule. Capability Roadmaps and Schedule. Purpose of NRC Review. Capability Roadmap Development (Progress to Date).

A Suggested Approach for Producing VAMS Air Transportation System Technology Roadmaps

NASA Technical Reports Server (NTRS)

Weathers, Del

2002-01-01

This viewgraph presentation provides an overview on the use of technology 'roadmaps' in order to facilitate the research development of VAMS (Virtual Airspace Modeling and Simulation). These roadmaps are to be produced by each concept team, updated annually, discussed at the technical interchange meetings (TIMs), shared among all VAMS participants, and made available electronically. These concept-specific technology roadmaps will be subsequently blended into an integrated catalog of roadmaps, technical discussions, and research recommendations. A historical example of ATM (Air Traffic Management) research and technology from 1940 to 1999 as shown in a series of 'roadmaps' is also included.

Patterning roadmap: 2017 prospects

NASA Astrophysics Data System (ADS)

Neisser, Mark

2017-06-01

Road mapping of semiconductor chips has been underway for over 20 years, first with the International Technology Roadmap for Semiconductors (ITRS) roadmap and now with the International Roadmap for Devices and Systems (IRDS) roadmap. The original roadmap was mostly driven bottom up and was developed to ensure that the large numbers of semiconductor producers and suppliers had good information to base their research and development on. The current roadmap is generated more top-down, where the customers of semiconductor chips anticipate what will be needed in the future and the roadmap projects what will be needed to fulfill that demand. The More Moore section of the roadmap projects that advanced logic will drive higher-resolution patterning, rather than memory chips. Potential solutions for patterning future logic nodes can be derived as extensions of `next-generation' patterning technologies currently under development. Advanced patterning has made great progress, and two `next-generation' patterning technologies, EUV and nanoimprint lithography, have potential to be in production as early as 2018. The potential adoption of two different next-generation patterning technologies suggests that patterning technology is becoming more specialized. This is good for the industry in that it lowers overall costs, but may lead to slower progress in extending any one patterning technology in the future.

National Research Council Dialogue to Assess Progress on NASA's Systems Engineering Cost/Risk Analysis Capability Roadmap Development: General Background and Introduction

NASA Technical Reports Server (NTRS)

Regenie, Victoria

2005-01-01

Contents include the following: General Background and Introduction of Capability. Roadmaps for Systems Engineering Cost/Risk Analysis. Agency Objectives. Strategic Planning Transformation. Review Capability Roadmaps and Schedule. Review Purpose of NRC Review. Capability Roadmap Development (Progress to Date).

Human Planetary Landing System (HPLS) Capability Roadmap NRC Progress Review

NASA Technical Reports Server (NTRS)

Manning, Rob; Schmitt, Harrison H.; Graves, Claude

2005-01-01

Capability Roadmap Team. Capability Description, Scope and Capability Breakdown Structure. Benefits of the HPLS. Roadmap Process and Approach. Current State-of-the-Art, Assumptions and Key Requirements. Top Level HPLS Roadmap. Capability Presentations by Leads. Mission Drivers Requirements. "AEDL" System Engineering. Communication & Navigation Systems. Hypersonic Systems. Super to Subsonic Decelerator Systems. Terminal Descent and Landing Systems. A Priori In-Situ Mars Observations. AEDL Analysis, Test and Validation Infrastructure. Capability Technical Challenges. Capability Connection Points to other Roadmaps/Crosswalks. Summary of Top Level Capability. Forward Work.

Book of Knowledge (BOK) for NASA Electronic Packaging Roadmap

NASA Technical Reports Server (NTRS)

Ghaffarian, Reza

2015-01-01

The objective of this document is to update the NASA roadmap on packaging technologies (initially released in 2007) and to present the current trends toward further reducing size and increasing functionality. Due to the breadth of work being performed in the area of microelectronics packaging, this report presents only a number of key packaging technologies detailed in three industry roadmaps for conventional microelectronics and a more recently introduced roadmap for organic and printed electronics applications. The topics for each category were down-selected by reviewing the 2012 reports of the International Technology Roadmap for Semiconductor (ITRS), the 2013 roadmap reports of the International Electronics Manufacturing Initiative (iNEMI), the 2013 roadmap of association connecting electronics industry (IPC), the Organic Printed Electronics Association (OE-A). The report also summarizes the results of numerous articles and websites specifically discussing the trends in microelectronics packaging technologies.

76 FR 66040 - NIST Framework and Roadmap for Smart Grid Interoperability Standards, Release 2.0 (Draft...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-25

...-01] NIST Framework and Roadmap for Smart Grid Interoperability Standards, Release 2.0 (Draft... draft version of the NIST Framework and Roadmap for Smart Grid Interoperability Standards, Release 2.0... Roadmap for Smart Grid Interoperability Standards, Release 2.0 (Release 2.0) (Draft) for public review and...

An Interim Report on NASA's Draft Space Technology Roadmaps

NASA Technical Reports Server (NTRS)

2011-01-01

NASA has developed a set of 14 draft roadmaps to guide the development of space technologies under the leadership of the NASA Office of the Chief Technologist (OCT). Each of these roadmaps focuses on a particular technology area (TA). The roadmaps are intended to foster the development of advanced technologies and concepts that address NASA's needs and contribute to other aerospace and national needs. OCT requested that the National Research Council conduct a study to review the draft roadmaps, gather and assess relevant community input, and make recommendations and suggest priorities to inform NASA's decisions as it finalizes its roadmaps. The statement of task states that "based on the results of the community input and its own deliberations, the steering committee will prepare a brief interim report that addresses high-level issues associated with the roadmaps, such as the advisability of modifying the number or technical focus of the draft NASA roadmaps." This interim report, which does not include formal recommendations, addresses that one element of the study charge. NASA requested this interim report so that it would have the opportunity to make an early start in modifying the draft roadmaps based on feedback from the panels and steering committee. The final report will address all other tasks in the statement of task. In particular, the final report will include a prioritization of technologies, will describe in detail the prioritization process and criteria, and will include specific recommendations on a variety of topics, including many of the topics mentioned in this interim report. In developing both this interim report and the final report to come, the steering committee draws on the work of six study panels organized by technical area, loosely following the organization of the 14 roadmaps, as follows: A Panel 1: Propulsion and Power TA01 Launch Propulsion Systems TA02 In-Space Propulsion Technologies TA03 Space Power and Energy Storage Systems TA13 Ground and Launch Systems Processing B Panel 2: Robotics, Communications, and Navigation TA04 Robotics, TeleRobotics, and Autonomous Systems TA05 Communication and Navigation Systems C Panel 3: Instruments and Computing TA08 Science Instruments, Observatories, and Sensor Systems TA11 Modeling, Simulation, Information Technology, and Data Processing D Panel 4: Human Health and Surface Exploration TA06 Human Health, Life Support, and Habitation Systems TA07 Human Exploration Destination Systems E Panel 5: Materials Panel TA10 Nanotechnology TA12 Materials, Structures, Mechanical Systems, and Manufacturing TA14 Thermal Management Systems F Panel 6: Entry, Descent, and Landing Panel TA09 Entry, Descent, and Landing Systems In addition to drawing on the expertise represented on the steering committee and panels, the committee obtained input from each of 14 public workshops held on each of the 14 roadmaps. At these 1-day workshops, invited speakers, guests, and members of the public engaged in discussions on the different technology areas and their value to NASA. Broad community input was also solicited from a public website, where more than 240 public comments were received on the draft roadmaps in response to application of criteria (such as benefit, risk and reasonableness, and alignment with NASA and national goals) that the steering committee established. This interim report reflects the results of deliberations by the steering committee in light of these public inputs as well as additional inputs from the six panels. The steering committee's final report will be completed early in 2012. That report will prioritize the technologies that span the entire scope of the 14 roadmaps and provide additional guidance on crosscutting themes and other relevant topics.

Flight Avionics Hardware Roadmap

NASA Technical Reports Server (NTRS)

Hodson, Robert; McCabe, Mary; Paulick, Paul; Ruffner, Tim; Some, Rafi; Chen, Yuan; Vitalpur, Sharada; Hughes, Mark; Ling, Kuok; Redifer, Matt;

Future cancer research priorities in the USA: a Lancet Oncology Commission.

PubMed

Jaffee, Elizabeth M; Dang, Chi Van; Agus, David B; Alexander, Brian M; Anderson, Kenneth C; Ashworth, Alan; Barker, Anna D; Bastani, Roshan; Bhatia, Sangeeta; Bluestone, Jeffrey A; Brawley, Otis; Butte, Atul J; Coit, Daniel G; Davidson, Nancy E; Davis, Mark; DePinho, Ronald A; Diasio, Robert B; Draetta, Giulio; Frazier, A Lindsay; Futreal, Andrew; Gambhir, Sam S; Ganz, Patricia A; Garraway, Levi; Gerson, Stanton; Gupta, Sumit; Heath, James; Hoffman, Ruth I; Hudis, Cliff; Hughes-Halbert, Chanita; Ibrahim, Ramy; Jadvar, Hossein; Kavanagh, Brian; Kittles, Rick; Le, Quynh-Thu; Lippman, Scott M; Mankoff, David; Mardis, Elaine R; Mayer, Deborah K; McMasters, Kelly; Meropol, Neal J; Mitchell, Beverly; Naredi, Peter; Ornish, Dean; Pawlik, Timothy M; Peppercorn, Jeffrey; Pomper, Martin G; Raghavan, Derek; Ritchie, Christine; Schwarz, Sally W; Sullivan, Richard; Wahl, Richard; Wolchok, Jedd D; Wong, Sandra L; Yung, Alfred

2017-11-01

We are in the midst of a technological revolution that is providing new insights into human biology and cancer. In this era of big data, we are amassing large amounts of information that is transforming how we approach cancer treatment and prevention. Enactment of the Cancer Moonshot within the 21st Century Cures Act in the USA arrived at a propitious moment in the advancement of knowledge, providing nearly US$2 billion of funding for cancer research and precision medicine. In 2016, the Blue Ribbon Panel (BRP) set out a roadmap of recommendations designed to exploit new advances in cancer diagnosis, prevention, and treatment. Those recommendations provided a high-level view of how to accelerate the conversion of new scientific discoveries into effective treatments and prevention for cancer. The US National Cancer Institute is already implementing some of those recommendations. As experts in the priority areas identified by the BRP, we bolster those recommendations to implement this important scientific roadmap. In this Commission, we examine the BRP recommendations in greater detail and expand the discussion to include additional priority areas, including surgical oncology, radiation oncology, imaging, health systems and health disparities, regulation and financing, population science, and oncopolicy. We prioritise areas of research in the USA that we believe would accelerate efforts to benefit patients with cancer. Finally, we hope the recommendations in this report will facilitate new international collaborations to further enhance global efforts in cancer control. Copyright © 2017 Elsevier Ltd. All rights reserved.

Renewed Global Partnerships and Redesigned Roadmaps for Rabies Prevention and Control

PubMed Central

Lembo, Tiziana; Attlan, Michaël; Bourhy, Hervé; Cleaveland, Sarah; Costa, Peter; de Balogh, Katinka; Dodet, Betty; Fooks, Anthony R.; Hiby, Elly; Leanes, Fernando; Meslin, François-Xavier; Miranda, Mary Elizabeth; Müller, Thomas; Nel, Louis H.; Rupprecht, Charles E.; Tordo, Noël; Tumpey, Abbigail; Wandeler, Alexander; Briggs, Deborah J.

2011-01-01

Canine rabies, responsible for most human rabies deaths, is a serious global public health concern. This zoonosis is entirely preventable, but by focusing solely upon rabies prevention in humans, this “incurable wound” persists at high costs. Although preventing human deaths through canine rabies elimination is feasible, dog rabies control is often neglected, because dogs are not considered typical economic commodities by the animal health sector. Here, we demonstrate that the responsibility of managing rabies falls upon multiple sectors, that a truly integrated approach is the key to rabies elimination, and that considerable progress has been made to this effect. Achievements include the construction of global rabies networks and organizational partnerships; development of road maps, operational toolkits, and a blueprint for rabies prevention and control; and opportunities for scaling up and replication of successful programs. Progress must continue towards overcoming the remaining challenges preventing the ultimate goal of rabies elimination. PMID:21776359

Roadmap to Measuring Distance Education Instructional Design Competencies

ERIC Educational Resources Information Center

Dooley, Kim E.; Lindner, James R.; Telg, Ricky W.; Irani, Tracy; Moore, Lori; Lundy, Lisa

2007-01-01

This study was designed to measure instructional design competencies as a result of participation in a 9-month Web-based training program called "Roadmap to Effective Distance Education Instructional Design." The researchers used a self-assessment pre- and posttest to determine participant initial and final competence in 12 areas: adult…

Roadmap on plasmonics

NASA Astrophysics Data System (ADS)

Stockman, Mark I.; Kneipp, Katrin; Bozhevolnyi, Sergey I.; Saha, Soham; Dutta, Aveek; Ndukaife, Justus; Kinsey, Nathaniel; Reddy, Harsha; Guler, Urcan; Shalaev, Vladimir M.; Boltasseva, Alexandra; Gholipour, Behrad; Krishnamoorthy, Harish N. S.; MacDonald, Kevin F.; Soci, Cesare; Zheludev, Nikolay I.; Savinov, Vassili; Singh, Ranjan; Groß, Petra; Lienau, Christoph; Vadai, Michal; Solomon, Michelle L.; Barton, David R., III; Lawrence, Mark; Dionne, Jennifer A.; Boriskina, Svetlana V.; Esteban, Ruben; Aizpurua, Javier; Zhang, Xiang; Yang, Sui; Wang, Danqing; Wang, Weijia; Odom, Teri W.; Accanto, Nicolò; de Roque, Pablo M.; Hancu, Ion M.; Piatkowski, Lukasz; van Hulst, Niek F.; Kling, Matthias F.

2018-04-01

Plasmonics is a rapidly developing field at the boundary of physical optics and condensed matter physics. It studies phenomena induced by and associated with surface plasmons—elementary polar excitations bound to surfaces and interfaces of good nanostructured metals. This Roadmap is written collectively by prominent researchers in the field of plasmonics. It encompasses selected aspects of nanoplasmonics. Among them are fundamental aspects, such as quantum plasmonics based on the quantum-mechanical properties of both the underlying materials and the plasmons themselves (such as their quantum generator, spaser), plasmonics in novel materials, ultrafast (attosecond) nanoplasmonics, etc. Selected applications of nanoplasmonics are also reflected in this Roadmap, in particular, plasmonic waveguiding, practical applications of plasmonics enabled by novel materials, thermo-plasmonics, plasmonic-induced photochemistry and photo-catalysis. This Roadmap is a concise but authoritative overview of modern plasmonics. It will be of interest to a wide audience of both fundamental physicists and chemists, as well as applied scientists and engineers.

NASA's Launch Propulsion Systems Technology Roadmap

NASA Technical Reports Server (NTRS)

McConnaughey, Paul K.; Femminineo, Mark G.; Koelfgen, Syri J.; Lepsch, Roger A; Ryan, Richard M.; Taylor, Steven A.

2012-01-01

Safe, reliable, and affordable access to low-Earth (LEO) orbit is necessary for all of the United States (US) space endeavors. In 2010, NASA s Office of the Chief Technologist commissioned 14 teams to develop technology roadmaps that could be used to guide the Agency s and US technology investment decisions for the next few decades. The Launch Propulsion Systems Technology Area (LPSTA) team was tasked to address the propulsion technology challenges for access to LEO. The developed LPSTA roadmap addresses technologies that enhance existing solid or liquid propulsion technologies and their related ancillary systems or significantly advance the technology readiness level (TRL) of less mature systems like airbreathing, unconventional, and other launch technologies. In developing this roadmap, the LPSTA team consulted previous NASA, military, and industry studies as well as subject matter experts to develop their assessment of this field, which has fundamental technological and strategic impacts for US space capabilities.

Focused Logistics, Joint Vision 2010: A Joint Logistics Roadmap

DTIC Science & Technology

2010-01-01

AIS). AIT devices include bar codes for individual items, optical memory cards for multipacks and containers, radio frequency tags for containers and...Fortezza Card and Firewall technologies are being developed to prevent unau- thorized access. As for infrastructure, DISA has already made significant in...radio frequency tags and optical memory cards , to continuously update the JTAV database. By September 1998, DSS will be deployed in all wholesale

A Roadmap for Future Security in the Western Balkans

DTIC Science & Technology

2012-03-22

and a specific cultural ambience.”5 In its historical background, the Balkan region was full of lasting frictions and security dilemmas. Probably...full moral , political, and diplomatic authority in a coherent and consistent way.”45 Although the EU has made a lot of organizational and... moral and pragmatic reasons toward the Western Balkan crisis in order to prevent the worst case scenario: escalating conflicts in Europe, and the

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sailer, Anna M., E-mail: anni.sailer@mumc.nl; Haan, Michiel W. de, E-mail: m.de.haan@mumc.nl; Graaf, Rick de, E-mail: r.de.graaf@mumc.nl

PurposeThis study was designed to evaluate the feasibility of endovascular guidance by means of live fluoroscopy fusion with magnetic resonance angiography (MRA) and computed tomography angiography (CTA).MethodsFusion guidance was evaluated in 20 endovascular peripheral artery interventions in 17 patients. Fifteen patients had received preinterventional diagnostic MRA and two patients had undergone CTA. Time for fluoroscopy with MRA/CTA coregistration was recorded. Feasibility of fusion guidance was evaluated according to the following criteria: for every procedure the executing interventional radiologists recorded whether 3D road-mapping provided added value (yes vs. no) and whether PTA and/or stenting could be performed relying on the fusionmore » road-map without need for diagnostic contrast-enhanced angiogram series (CEAS) (yes vs. no). Precision of the fusion road-map was evaluated by recording maximum differences between the position of the vasculature on the virtual CTA/MRA images and conventional angiography.ResultsAverage time needed for image coregistration was 5 ± 2 min. Three-dimensional road-map added value was experienced in 15 procedures in 12 patients. In half of the patients (8/17), intervention was performed relying on the fusion road-map only, without diagnostic CEAS. In two patients, MRA roadmap showed a false-positive lesion. Excluding three patients with inordinate movements, mean difference in position of vasculature on angiography and MRA/CTA road-map was 1.86 ± 0.95 mm, implying that approximately 95 % of differences were between 0 and 3.72 mm (2 ± 1.96 standard deviation).ConclusionsFluoroscopy with MRA/CTA fusion guidance for peripheral artery interventions is feasible. By reducing the number of CEAS, this technology may contribute to enhance procedural safety.« less

A Roadmap for Recovery/Decontamination Plan for Critical Infrastructure after CBRN Event Involving Drinking Water Utilities: Scoping Study

DTIC Science & Technology

2014-05-01

A Roadmap for Recovery/Decontamination Plan for Critical Infrastructure after CBRN Event Involving Drinking Water Utilities: Scoping Study... Drinking Water Utilities was supported by the Canadian Safety and Security Program (CSSP) which is led by Defence Research and Development Canada’s Centre...after CBRN Event Involving Drinking Water Utilities Scoping Study Prepared by: Vladimir Blinov Konstantin Volchek Emergencies Science and

EUROGIN 2011 roadmap on prevention and treatment of HPV-related disease

PubMed Central

Arbyn, Marc; de Sanjosé, Silvia; Saraiya, Mona; Sideri, Mario; Palefsky, Joel; Lacey, Charles; Gillison, Maura; Bruni, Laia; Ronco, Guglielmo; Wentzensen, Nicolas; Brotherton, Julia; Qiao, You-Lin; Denny, Lynnette; Bornstein, Jacob; Abramowitz, Laurent; Giuliano, Anna; Tommasino, Massimo; Monsonego, Joseph

2012-01-01

The EUROGIN 2011 roadmap reviews the current burden of HPV (human papillomavirus)-related morbidity, as well as the evidence and potential practice recommendations regarding primary and secondary prevention and treatment of cancers and other disease associated with HPV infection. HPV infection causes approximately 600,000 cases of cancer of the cervix, vulva, vagina, anus and oropharynx annually, as well as benign diseases such as genital warts and recurrent respiratory papillomatosis. Whereas the incidence of cervical cancer has been decreasing over recent decades, the incidence of anal and oropharyngeal carcinoma, for which there are no effective screening programs, has been rising over the last couple of decades. Randomised trials have demonstrated improved efficacy of HPV-based compared to cytology-based cervical cancer screening. Defining the best algorithms to triage HPV-positive women, age ranges and screening intervals are priorities for pooled analyses and further research, whereas feasibility questions can be addressed through screening programmes. HPV vaccination will reduce the burden of cervical precancer and probably also of invasive cervical and other HPV-related disease in women. Recent trials demonstrated that prophylactic vaccination also protects against anogenital HPV infection, ano-genital intraepithelial lesions and warts associated with vaccine types, in males; and anal HPV infection and anal intraepithelial neoplasia in MSM. HPV-related oropharyngeal cancer could be treated less aggressively because of better survival compared to cancers of the oropharynx unrelated to HPV. Key findings in the field of cervical cancer prevention should now be translated in cost-effective strategies, following an organised approach integrating primary and secondary prevention, according to scientific evidence but adapted to the local situation with particular attention to regions with the highest burden of disease. PMID:22623137

USET Tribal-FERST Roadmap

EPA Pesticide Factsheets

The USET Tribal-FERST Roadmap was developed by the United South and Eastern Tribes (USET), in collaboration with the EPA, as a general roadmap for other tribes to follow and modify as needed fortheir unique applications.

OCCURRENCE, GENOTOXICITY, AND CARCINOGENICITY OF EMERGING DISINFECTION BY-PRODUCTS IN DRINKING WATER: A REVIEW AND ROADMAP FOR RESEARCH

EPA Science Inventory

Occurrence, Genotoxicity, and Carcinogenicity of Emerging Disinfection By-products in Drinking Water: A Review and Roadmap for Research
Summary of Paper
What is study?
This is the first review of the 30 year's research effort on the occurrence, genotoxicity,...

River Protection Project Technology and Innovation Roadmap.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reid, D. S.; Wooley, T. A.; Kelly, S. E.

The Technology and Innovation Roadmap is a planning tool for WRPS management, DOE ORP, DOE EM, and others to understand the risks and technology gaps associated with the RPP mission. The roadmap identifies and prioritizes technical areas that require technology solutions and underscores where timely and appropriate technology development can have the greatest impact to reduce those risks and uncertainties. The roadmap also serves as a tool for determining allocation of resources.

[To promote universal eye health to push forward sustaining development of the prevention of blindness in China].

PubMed

Zhao, Jialiang

2014-03-01

Action plan for the prevention of avoidable blindness and visual impairment for 2014-2019 endorsed by 66(th) World Health Assembly is an important document for promoting the global prevention of blindness. This action plan summarized the experiences and lessons in the global prevention of avoidable blindness and visual impairment from 2009 to 2013, raised the global goal for the prevention of blindness-the reduction in prevalence of avoidable visual impairment by 25% by 2019 from the baseline of 2010, set up the monitoring indicators for realizing the global goal. This document can be served as a roadmap to consolidate joint efforts aimed at working towards universal eye health in the world. This action plan must give a deep and important impact on the prevention of blindness in China.We should implement the action plan for the prevention of avoidable blindness and visual impairment for 2014-2019 to push forward sustaining development of the prevention of blindness in China.

Research & Development Roadmap for Next-Generation Appliances

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goetzler, William; Sutherland, Timothy; Foley, Kevin

2012-03-01

Appliances present an attractive opportunity for near-term energy savings in existing building, because they are less expensive and replaced more regularly than heating, ventilation, and air-conditioning (HVAC) systems or building envelope components. This roadmap targets high-priority research and development (R&D), demonstration and commercialization activities that could significantly reduce residential appliance energy consumption. The main objective of the roadmap is to seek activities that accelerate the commercialization of high-efficiency appliance technologies while maintaining the competitiveness of American industry. The roadmap identified and evaluated potential technical innovations, defined research needs, created preliminary research and development roadmaps, and obtained stakeholder feedback on themore » proposed initiatives.« less

Bioastronautics Roadmap: A Risk Reduction Strategy for Human Space Exploration

NASA Technical Reports Server (NTRS)

2005-01-01

The Bioastronautics Critical Path Roadmap is the framework used to identify and assess the risks to crews exposed to the hazardous environments of space. It guides the implementation of research strategies to prevent or reduce those risks. Although the BCPR identifies steps that must be taken to reduce the risks to health and performance that are associated with human space flight, the BCPR is not a "critical path" analysis in the strict engineering sense. The BCPR will evolve to accommodate new information and technology development and will enable NASA to conduct a formal critical path analysis in the future. As a management tool, the BCPR provides information for making informed decisions about research priorities and resource allocation. The outcome-driven nature of the BCPR makes it amenable for assessing the focus, progress and success of the Bioastronautics research and technology program. The BCPR is also a tool for communicating program priorities and progress to the research community and NASA management.

Roadmap to developing a recombinant coronavirus S protein receptor-binding domain vaccine for severe acute respiratory syndrome

PubMed Central

Jiang, Shibo; Bottazzi, Maria Elena; Du, Lanying; Lustigman, Sara; Tseng, Chien-Te Kent; Curti, Elena; Jones, Kathryn; Zhan, Bin; Hotez, Peter J

2013-01-01

A subunit vaccine, RBD-S, is under development to prevent severe acute respiratory syndrome (SARS) caused by SARS coronavirus (SARS-CoV), which is classified by the US NIH as a category C pathogen. This vaccine is comprised of a recombinant receptor-binding domain (RBD) of the SARS-CoV spike (S) protein and formulated on alum, together with a synthetic glucopyranosyl lipid A. The vaccine would induce neutralizing antibodies without causing Th2-type immunopathology. Vaccine development is being led by the nonprofit product development partnership; Sabin Vaccine Institute and Texas Children’s Hospital Center for Vaccine Development in collaboration with two academic partners (the New York Blood Center and University of Texas Medical Branch); an industrial partner (Immune Design Corporation); and Walter Reed Army Institute of Research. A roadmap for the product development of the RBD-S SARS vaccine is outlined with a goal to manufacture the vaccine for clinical testing within the next 5 years. PMID:23252385

Teacher Quality Roadmap: Improving Policies and Practices in the Miami-Dade County Public Schools

ERIC Educational Resources Information Center

National Council on Teacher Quality, 2012

2012-01-01

In partnership with the Urban League of Greater Miami, the National Council on Teacher Quality (NCTQ) released "Teacher Quality Roadmap: Improving Policies and Practices in Miami," an in-depth study of the work rules Miami-Dade teachers. This look at the state of teacher policies in Miami-Dade County Public Schools explores the…

Internal Consistency in Components of International Management/International Business Syllabi: Roadmaps with Mixed Messages

ERIC Educational Resources Information Center

Veliyath, Rajaram; Adams, Janet S.

2005-01-01

The course syllabus is a contract between instructor and students, a schedule of course assignments and activities, and a roadmap delineating objectives and checkpoints in the course. It is also a planning and reference tool for both students and instructor, and it models professors' expectations for their students. This study investigated whether…

U.S. Army unmanned aircraft systems roadmap 2010-2035

DOT National Transportation Integrated Search

2010-01-01

The Unmanned Aircraft System (UAS) Roadmap outlines how the U.S. Army will develop, organize, and employ UAS from 2010 to 2035 across full spectrum operations. The Army UAS Roadmap is nested with the Unmanned Systems (UMS) Initial Capabilities Docume...

Commentary on "A roadmap for the prevention of dementia II. Leon Thal Symposium 2008." The Multidomain Alzheimer Preventive Trial (MAPT): a new approach to the prevention of Alzheimer's disease.

PubMed

Gillette-Guyonnet, Sophie; Andrieu, Sandrine; Dantoine, Thierry; Dartigues, Jean-François; Touchon, Jacques; Vellas, B

2009-03-01

Because no effective curative approaches are available, preventive approaches in the field of Alzheimer's disease (AD) are needed. We present the design of the ongoing Multidomain Alzheimer Preventive Trial (MAPT) Study. Several previous studies suggested that many factors may be involved in the occurrence of AD at late ages. Because of the probable multifactorial nature of AD, it seems logical to initiate multidomain interventions to examine their potential synergistic effects. The MAPT Study aims to evaluate the efficacy of a multidomain intervention (nutritional, physical, and cognitive training) and omega 3 treatment in the prevention of cognitive decline in frail elderly persons aged 70 years or over. The study also collects imaging and biological data that could be used in future AD prevention and treatment trials. The MAPT Study is a 3-year, randomized, controlled trial conducted by university hospital practitioners specializing in memory disorders in four French cities (Bordeaux, Limoges, Montpellier, and Toulouse). The study plans to enroll 1200 frail elderly subjects on the basis of at least one of the following criteria: subjective memory complaint spontaneously expressed to a general practitioner, limitation in one instrumental activity of daily living (IADL), and slow walking speed. To demonstrate the protective effect of interventions, subjects are randomized into one of the following four groups: omega 3 alone, multidomain intervention alone, omega 3 plus multidomain intervention, or placebo (n = 300 each). The principal outcome measure is a change in cognitive function at 3 years, as determined by the Grober and Buschke Test. The MAPT Study is the first preventive trial involving multidomain interventions. Final results should be available in 2013.

Advanced Accelerator Development Strategy Report: DOE Advanced Accelerator Concepts Research Roadmap Workshop

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

Over a full two day period, February 2–3, 2016, the Office of High Energy Physics convened a workshop in Gaithersburg, MD to seek community input on development of an Advanced Accelerator Concepts (AAC) research roadmap. The workshop was in response to a recommendation by the HEPAP Accelerator R&D Subpanel [1] [2] to “convene the university and laboratory proponents of advanced acceleration concepts to develop R&D roadmaps with a series of milestones and common down selection criteria towards the goal for constructing a multi-TeV e+e– collider” (the charge to the workshop can be found in Appendix A). During the workshop, proponentsmore » of laser-driven plasma wakefield acceleration (LWFA), particle-beam-driven plasma wakefield acceleration (PWFA), and dielectric wakefield acceleration (DWFA), along with a limited number of invited university and laboratory experts, presented and critically discussed individual concept roadmaps. The roadmap workshop was preceded by several preparatory workshops. The first day of the workshop featured presentation of three initial individual roadmaps with ample time for discussion. The individual roadmaps covered a time period extending until roughly 2040, with the end date assumed to be roughly appropriate for initial operation of a multi-TeV e+e– collider. The second day of the workshop comprised talks on synergies between the roadmaps and with global efforts, potential early applications, diagnostics needs, simulation needs, and beam issues and challenges related to a collider. During the last half of the day the roadmaps were revisited but with emphasis on the next five to ten years (as specifically requested in the charge) and on common challenges. The workshop concluded with critical and unanimous endorsement of the individual roadmaps and an extended discussion on the characteristics of the common challenges. (For the agenda and list of participants see Appendix B.)« less

Flight Avionics Hardware Roadmap

NASA Technical Reports Server (NTRS)

Some, Raphael; Goforth, Monte; Chen, Yuan; Powell, Wes; Paulick, Paul; Vitalpur, Sharada; Buscher, Deborah; Wade, Ray; West, John; Redifer, Matt;

Selected Nutrients and Their Implications for Health and Disease across the Lifespan: A Roadmap

PubMed Central

Péter, Szabolcs; Eggersdorfer, Manfred; van Asselt, Dieneke; Buskens, Erik; Detzel, Patrick; Freijer, Karen; Koletzko, Berthold; Kraemer, Klaus; Kuipers, Folkert; Neufeld, Lynnette; Obeid, Rima; Wieser, Simon; Zittermann, Armin; Weber, Peter

2014-01-01

Worldwide approximately two billion people have a diet insufficient in micronutrients. Even in the developed world, an increasing number of people consume nutrient-poor food on a regular basis. Recent surveys in Western countries consistently indicate inadequate intake of nutrients such as vitamins and minerals, compared to recommendations. The International Osteoporosis Foundation’s (IOF) latest figures show that globally about 88% of the population does not have an optimal vitamin D status. The Lancet’s “Global Burden of Disease Study 2010” demonstrates a continued growth in life expectancy for populations around the world; however, the last decade of life is often disabled by the burden of partly preventable health issues. Compelling evidence suggests that improving nutrition protects health, prevents disability, boosts economic productivity and saves lives. Investments to improve nutrition make a positive contribution to long-term national and global health, economic productivity and stability, and societal resilience. PMID:25533014

Leveraging Federal Funding for Longitudinal Data Systems: A Roadmap for States. Fiscal Year 2011

ERIC Educational Resources Information Center

Data Quality Campaign, 2011

2011-01-01

States should use this roadmap to identify and leverage federal funding sources for data-related activities. This roadmap presents such opportunities for FY 2011, and provides guidance on some of the ways the funds may be used.

Idaho National Engineering Laboratory Waste Management Operations Roadmap Document

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bullock, M.

1992-04-01

At the direction of the Department of Energy-Headquarters (DOE-HQ), the DOE Idaho Field Office (DOE-ID) is developing roadmaps for Environmental Restoration and Waste Management (ER&WM) activities at Idaho National Engineering Laboratory (INEL). DOE-ID has convened a select group of contractor personnel from EG&G Idaho, Inc. to assist DOE-ID personnel with the roadmapping project. This document is a report on the initial stages of the first phase of the INEL`s roadmapping efforts.

Research and Development Roadmaps for Liquid Metal Cooled Fast Reactors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, T. K.; Grandy, C.; Natesan, K.

The United States Department of Energy (DOE) commissioned the development of technology roadmaps for advanced (non-light water reactor) reactor concepts to help focus research and development funding over the next five years. The roadmaps show the research and development needed to support demonstration of an advanced (non-LWR) concept by the early 2030s, consistent with DOE’s Vision and Strategy for the Development and Deployment of Advanced Reactors. The intent is only to convey the technical steps that would be required to achieve such a goal; the means by which DOE will determine whether to invest in specific tasks will be treatedmore » separately. The starting point for the roadmaps is the Technical Readiness Assessment performed as part of an Advanced Test and Demonstration Reactor study released in 2016. The roadmaps were developed based upon a review of technical reports and vendor literature summarizing the technical maturity of each concept and the outstanding research and development needs. Critical path tasks for specific systems were highlighted on the basis of time and resources needed to complete the tasks and the importance of the system to the performance of the reactor concept. The roadmaps are generic, i.e. not specific to a particular vendor’s design but vendor design information may have been used as representative of the concept family. In the event that both near-term and more advanced versions of a concept are being developed, either a single roadmap with multiple branches or separate roadmaps for each version were developed. In each case, roadmaps point to a demonstration reactor (engineering or commercial) and show the activities that must be completed in parallel to support that demonstration in the 2030-2035 window. This report provides the roadmaps for two fast reactor concepts, the Sodium-cooled Fast Reactor (SFR) and the Lead-cooled Fast Reactor (LFR). The SFR technology is mature enough for commercial demonstration by the early 2030s, and the remaining critical paths and R&D needs are generally related to the completion of qualification of fuel and structural materials, validation of reactor design codes and methods, and support of the licensing frameworks. The LFR’s technology is instead less-mature compared to the SFR’s, and will be at the engineering demonstration stage by the early 2030s. Key LFR technology development activities will focus on resolving remaining design challenges and demonstrating the viability of systems and components in the integral system, which will be done in parallel with addressing the gaps shared with SFR technology. The approach and timeline presented here assume that, for the first module demonstration, vendors would pursue a two-step licensing process based on 10CFR Part 50.« less

Progress along the E-ELT instrumentation roadmap

NASA Astrophysics Data System (ADS)

Ramsay, Suzanne; Casali, Mark; Cirasuolo, Michele; Egner, Sebastian; Gray, Peter; Gonzáles Herrera, Juan Carlos; Hammersley, Peter; Haupt, Christoph; Ives, Derek; Jochum, Lieselotte; Kasper, Markus; Kerber, Florian; Lewis, Steffan; Mainieri, Vincenzo; Manescau, Antonio; Marchetti, Enrico; Oberti, Sylvain; Padovani, Paolo; Schmid, Christian; Schimpelsberger, Johannes; Siebenmorgen, Ralf; Szecsenyi, Orsolya; Tamai, Roberto; Vernet, Joël.

2016-08-01

A suite of seven instruments and associated AO systems have been planned as the "E-ELT Instrumentation Roadmap". Following the E-ELT project approval in December 2014, rapid progress has been made in organising and signing the agreements for construction with European universities and institutes. Three instruments (HARMONI, MICADO and METIS) and one MCAO module (MAORY) have now been approved for construction. In addition, Phase-A studies have begun for the next two instruments - a multi-object spectrograph and high-resolution spectrograph. Technology development is also ongoing in preparation for the final instrument in the roadmap, the planetary camera and spectrograph. We present a summary of the status and capabilities of this first set of instruments for the E-ELT.

Policy and Technology Readiness: Engaging the User and Developer Community to Develop a Research Roadmap

DOE Office of Scientific and Technical Information (OSTI.GOV)

Olson, Jarrod; Barr, Jonathan L.; Burtner, Edwin R.

A key challenge for research roadmapping in the crisis response and management domain is articulation of a shared vision that describes what the future can and should include. Visioning allows for far-reaching stakeholder engagement that can properly align research with stakeholders needs. Engagement includes feedback from researchers, policy makers, general public, and end-users on technical and non-technical factors. This work articulates a process and framework for the construction and maintenance of a stakeholder-centric research vision and roadmap in the emergency management domain. This novel roadmapping process integrates three pieces: analysis of the research and technology landscape, visioning, and stakeholder engagement.more » Our structured engagement process elicits research foci for the roadmap based on relevance to stakeholder mission, identifies collaborators, and builds consensus around the roadmap priorities. We find that the vision process and vision storyboard helps SMEs conceptualize and discuss a technology's strengths, weaknesses, and alignment with needs« less

Mission to the Solar System: Exploration and Discovery. A Mission and Technology Roadmap

NASA Technical Reports Server (NTRS)

Gulkis, S. (Editor); Stetson, D. S. (Editor); Stofan, E. R. (Editor)

1998-01-01

Solar System exploration addresses some of humanity's most fundamental questions: How and when did life form on Earth? Does life exist elsewhere in the Solar System or in the Universe? - How did the Solar System form and evolve in time? - What can the other planets teach us about the Earth? This document describes a Mission and Technology Roadmap for addressing these and other fundamental Solar System Questions. A Roadmap Development Team of scientists, engineers, educators, and technologists worked to define the next evolutionary steps in in situ exploration, sample return, and completion of the overall Solar System survey. Guidelines were to "develop aa visionary, but affordable, mission and technology development Roadmap for the exploration of the Solar System in the 2000 to 2012 timeframe." The Roadmap provides a catalog of potential flight missions. (Supporting research and technology, ground-based observations, and laboratory research, which are no less important than flight missions, are not included in this Roadmap.)

The Advanced Modeling, Simulation and Analysis Capability Roadmap Vision for Engineering

NASA Technical Reports Server (NTRS)

Zang, Thomas; Lieber, Mike; Norton, Charles; Fucik, Karen

2006-01-01

This paper summarizes a subset of the Advanced Modeling Simulation and Analysis (AMSA) Capability Roadmap that was developed for NASA in 2005. The AMSA Capability Roadmap Team was chartered to "To identify what is needed to enhance NASA's capabilities to produce leading-edge exploration and science missions by improving engineering system development, operations, and science understanding through broad application of advanced modeling, simulation and analysis techniques." The AMSA roadmap stressed the need for integration, not just within the science, engineering and operations domains themselves, but also across these domains. Here we discuss the roadmap element pertaining to integration within the engineering domain, with a particular focus on implications for future observatory missions. The AMSA products supporting the system engineering function are mission information, bounds on information quality, and system validation guidance. The Engineering roadmap element contains 5 sub-elements: (1) Large-Scale Systems Models, (2) Anomalous Behavior Models, (3) advanced Uncertainty Models, (4) Virtual Testing Models, and (5) space-based Robotics Manufacture and Servicing Models.

In-Situ Resource Utilization (ISRU) Capability Roadmap Progress Review

NASA Technical Reports Server (NTRS)

Sanders, Gerald B.; Duke, Michael

2005-01-01

A progress review on In-Situ Resource Utilization (ISRU) capability is presented. The topics include: 1) In-Situ Resource Utilization (ISRU) Capability Roadmap: Level 1; 2) ISRU Emphasized Architecture Overview; 3) ISRU Capability Elements: Level 2 and below; and 4) ISRU Capability Roadmap Wrap-up.

Cost-Reduction Roadmap for Residential Solar Photovoltaics (PV),

Science.gov Websites

2017-2030 | Solar Research | NREL Cost-Reduction Roadmap for Residential Solar Photovoltaics (PV), 2017-2030 Cost-Reduction Roadmap for Residential Solar Photovoltaics (PV), 2017-2030 This report Office (SETO) residential 2030 photovoltaics (PV) cost target of $0.05 per kilowatt-hour by identifying

The 2017 Plasma Roadmap: Low temperature plasma science and technology

USDA-ARS?s Scientific Manuscript database

Journal of Physics D: Applied Physics published the first Plasma Roadmap in 2012 consisting of the individual perspectives of 16 leading experts in the various sub-fields of low temperature plasma science and technology. The 2017 Plasma Roadmap is the first update of a planned series of periodic upd...

NASA Strategic Roadmap Committees Final Roadmaps. Volumes 1 and 2

NASA Technical Reports Server (NTRS)

2005-01-01

Volume 1 contains NASA strategic roadmaps for the following Advanced Planning and Integration Office (APIO) committees: Earth Science and Applications from Space; Sun - Solar System Connection. Volume 2 contains NASA strategic roadmaps for the following APIO committees: Robotic and Human Exploration of Mars; Solar System Exploration; Search for Earth-like Planets; Universe Exploration, as well as membership rosters and charters for all APIO committees, including those above and the following: Exploration Transportation System; Nuclear Systems; Robotic and Human Lunar Exploration; Aeronautical Technologies; Space Shuttle; International Space Station; Education.

Resolving Risks in Individual Astronauts: A New Paradigm for Critical Path Exposures

NASA Technical Reports Server (NTRS)

Richmond, Robert C.

2005-01-01

The limited number of astronauts available for risk-assessment prevents classic epidemiologic study, and thereby requires alternative approach to assessing risks within individual astronauts exposed to toxic agents identified within the Bioastronautics Critical Path Roadmap (BCPR). Developing a system of noninvasive real-time biodosimetry that provides large datasets for analyses before, during, and after missions for simultaneously determining 1) the kinds of toxic insult, 2) the degree of that insult, both within tissues absorbing that insult, would be usehl for resolving statistically significant risk-assessment in individual astronauts. Therefore, a currently achievable multiparametric paradigm is presented for use in analyzing gene-expression and protein-expression so as to establish predictive outcomes.

A Roadmap for Cybersecurity Research

DTIC Science & Technology

2009-11-01

Compile and compare existing studies relating to the insider threat. (Detect) �� Develop data collection mechanisms and collect data. (Detect...for capturing provenance. The model aims to make it easier for provenance to be exchanged between systems, to support development of provenance... It is the opinion of those involved in creating this research roadmap that government-funded research and development (R&D) must play an increasing

NASA Space Technology Roadmaps and Priorities: Restoring NASA's Technological Edge and Paving the Way for a New Era in Space

NASA Technical Reports Server (NTRS)

2012-01-01

Success in executing future NASA space missions will depend on advanced technology developments that should already be underway. It has been years since NASA has had a vigorous, broad-based program in advanced space technology development, and NASA's technology base is largely depleted. As noted in a recent National Research Council report on the U.S. civil space program: Future U.S. leadership in space requires a foundation of sustained technology advances that can enable the development of more capable, reliable, and lower-cost spacecraft and launch vehicles to achieve space program goals. A strong advanced technology development foundation is needed also to enhance technology readiness of new missions, mitigate their technological risks, improve the quality of cost estimates, and thereby contribute to better overall mission cost management. Yet financial support for this technology base has eroded over the years. The United States is now living on the innovation funded in the past and has an obligation to replenish this foundational element. NASA has developed a draft set of technology roadmaps to guide the development of space technologies under the leadership of the NASA Office of the Chief Technologist. The NRC appointed the Steering Committee for NASA Technology Roadmaps and six panels to evaluate the draft roadmaps, recommend improvements, and prioritize the technologies within each and among all of the technology areas as NASA finalizes the roadmaps. The steering committee is encouraged by the initiative NASA has taken through the Office of the Chief Technologist (OCT) to develop technology roadmaps and to seek input from the aerospace technical community with this study.

The NASA Electronic Parts and Packaging (NEPP) Program: Roadmap for FY15 and Beyond and Recent Radiation Highlights

NASA Technical Reports Server (NTRS)

LaBel, Kenneth A.; Sampson, Michael J.

2015-01-01

This presentation is a NASA Electronic Parts and Packaging (NEPP) Program: Roadmap for FY15 and Beyond. This roadmap provides a snapshot for current plans and collaborations on testing and evaluation of electronics as well as a discussion of the technology selection approach.

Single-entry models (SEMs) for scheduled services: Towards a roadmap for the implementation of recommended practices.

PubMed

Lopatina, Elena; Damani, Zaheed; Bohm, Eric; Noseworthy, Tom W; Conner-Spady, Barbara; MacKean, Gail; Simpson, Chris S; Marshall, Deborah A

2017-09-01

Long waiting times for elective services continue to be a challenging issue. Single-entry models (SEMs) are used to increase access to and flow through the healthcare system. This paper provides a roadmap for healthcare decision-makers, managers, physicians, and researchers to guide implementation and management of successful and sustainable SEMs. The roadmap was informed by an inductive qualitative synthesis of the findings from a deliberative process (a symposium on SEMs, with clinicians, researchers, senior policy-makers, healthcare managers, and patient representatives) and focus groups with the symposium participants. SEMs are a promising strategy to improve the management of referrals and represent one approach to reduce waiting times. The SEMs roadmap outlines current knowledge about SEMs and critical success factors for SEMs' implementation and management. This SEM roadmap is intended to help clinicians, decision-makers, managers, and researchers interested in developing new or strengthening existing SEMs. We consider this roadmap to be a living document that will continue to evolve as we learn more about implementing and managing sustainable SEMs. Copyright © 2017 Elsevier B.V. All rights reserved.

The 2017 Plasma Roadmap: Low temperature plasma science and technology

NASA Astrophysics Data System (ADS)

Adamovich, I.; Baalrud, S. D.; Bogaerts, A.; Bruggeman, P. J.; Cappelli, M.; Colombo, V.; Czarnetzki, U.; Ebert, U.; Eden, J. G.; Favia, P.; Graves, D. B.; Hamaguchi, S.; Hieftje, G.; Hori, M.; Kaganovich, I. D.; Kortshagen, U.; Kushner, M. J.; Mason, N. J.; Mazouffre, S.; Mededovic Thagard, S.; Metelmann, H.-R.; Mizuno, A.; Moreau, E.; Murphy, A. B.; Niemira, B. A.; Oehrlein, G. S.; Petrovic, Z. Lj; Pitchford, L. C.; Pu, Y.-K.; Rauf, S.; Sakai, O.; Samukawa, S.; Starikovskaia, S.; Tennyson, J.; Terashima, K.; Turner, M. M.; van de Sanden, M. C. M.; Vardelle, A.

2017-08-01

Journal of Physics D: Applied Physics published the first Plasma Roadmap in 2012 consisting of the individual perspectives of 16 leading experts in the various sub-fields of low temperature plasma science and technology. The 2017 Plasma Roadmap is the first update of a planned series of periodic updates of the Plasma Roadmap. The continuously growing interdisciplinary nature of the low temperature plasma field and its equally broad range of applications are making it increasingly difficult to identify major challenges that encompass all of the many sub-fields and applications. This intellectual diversity is ultimately a strength of the field. The current state of the art for the 19 sub-fields addressed in this roadmap demonstrates the enviable track record of the low temperature plasma field in the development of plasmas as an enabling technology for a vast range of technologies that underpin our modern society. At the same time, the many important scientific and technological challenges shared in this roadmap show that the path forward is not only scientifically rich but has the potential to make wide and far reaching contributions to many societal challenges.

National Algal Biofuels Technology Roadmap

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ferrell, John; Sarisky-Reed, Valerie

The framework for National Algal Biofuels Technology Roadmap was constructed at the Algal Biofuels Technology Roadmap Workshop, held December 9-10, 2008, at the University of Maryland-College Park. The Workshop was organized by the Biomass Program to discuss and identify the critical challenges currently hindering the development of a domestic, commercial-scale algal biofuels industry. This Roadmap presents information from a scientific, economic, and policy perspectives that can support and guide RD&D investment in algal biofuels. While addressing the potential economic and environmental benefits of using algal biomass for the production of liquid transportation fuels, the Roadmap describes the current status ofmore » algae RD&D. In doing so, it lays the groundwork for identifying challenges that likely need to be overcome for algal biomass to be used in the production of economically viable biofuels.« less

National roadmap for research infrastructure

NASA Astrophysics Data System (ADS)

Bonev, Tanyu

In 2010 the Council of Ministers of Republic of Bulgaria passed a National roadmap for research infrastructure (Decision Num. 692 from 21.09.2010). Part of the roadmap is the project called Regional Astronomical Center for Research and Education (RACIO). Distinctive feature of this project is the integration of the existing in the country research and educational organizations in the field of astronomy. The project is a substantial part of the strategy for the development of astronomy in Bulgaria over the next decade. What is the content of this strategis project? How it was possible to include RACIO in the roadmap? Does the national roadmap charmonize with the strategic plans for the development of astronomy in Europe, elaborated by Astronet (http://www.astronet-eu.org/)? These are some of the questions which I try to give answers in this paper.

The global roadmap for advancing development of vaccines against sexually transmitted infections: Update and next steps.

PubMed

Gottlieb, Sami L; Deal, Carolyn D; Giersing, Birgitte; Rees, Helen; Bolan, Gail; Johnston, Christine; Timms, Peter; Gray-Owen, Scott D; Jerse, Ann E; Cameron, Caroline E; Moorthy, Vasee S; Kiarie, James; Broutet, Nathalie

2016-06-03

In 2014, the World Health Organization, the US National Institutes of Health, and global technical partners published a comprehensive roadmap for development of new vaccines against sexually transmitted infections (STIs). Since its publication, progress has been made in several roadmap activities: obtaining better epidemiologic data to establish the public health rationale for STI vaccines, modeling the theoretical impact of future vaccines, advancing basic science research, defining preferred product characteristics for first-generation vaccines, and encouraging investment in STI vaccine development. This article reviews these overarching roadmap activities, provides updates on research and development of individual vaccines against herpes simplex virus, Chlamydia trachomatis, Neisseria gonorrhoeae, and Treponema pallidum, and discusses important next steps to advance the global roadmap for STI vaccine development. Copyright © 2016 World Health Organization. Published by Elsevier Ltd.. All rights reserved.

Carbon Dioxide Utilization (CO2U) ICEF Roadmap 2.0. Draft October 2017

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sandalow, David; Aines, Roger; Friedmann, Julio

Last year, experts from CO 2 Sciences, Columbia University and Valence Strategic came together to develop a roadmap. That document, Carbon Dioxide Utilization ICEF Roadmap 1.0, released at the UNFCCC Marrakesh Climate Change Conference in 2016, surveyed the commercial and technical landscape of CO 2 conversion and use. The document provided extensive background and analysis and has helped to provide a foundation for additional studies, including this one.This roadmap is meant to complement and expand upon the work of its predecessor. Based in part on a workshop at Columbia University’s Center on Global Energy Policy in July 2017, it exploresmore » three distinct categories of CO 2-based products, the technologies that can be harnessed to convert CO2 to these products, and the associated research and development needs. It also explores the complicated topic of life cycle analysis—critically important when considering the climate impacts of CO 2 conversion and use—as well as policy tools that could be used to promote CO 2-based products.« less

A Call to Action: Getting Denver Public Schools Students Back on Track to Graduation. An Analysis of DPS' Off-Track Youth, in and out of School, and a Roadmap for Improving Educational Options

ERIC Educational Resources Information Center

Dolan, Kim Knous; Perez-Oquendo, Reyna

2009-01-01

More than half of all Denver Public Schools (DPS) students who start in the ninth grade do not graduate within four years. If DPS is to significantly impact this graduation crisis, it must prioritize the implementation of systemic and research-based strategies around prevention, recuperation, and recovery of off-track students. With a 100 percent…

Electronic Combat Roadmap for Space.

DTIC Science & Technology

1988-04-01

studies which are required to obtain the necessary data to create that roadmap. vii MO Chapter One INTRODUCTION This paper begins the effort to create an...zstems Information Study T 4ke the effort on threat sytmthe :,ope of the task call-ed for in Chapter Six In this area is also largs-e. Again, as a...firs-t step, a survey-level project should be done. This onp will Frobably be mcre difficult than. the one oln threat syteT because in a lot of cases

NASA capabilities roadmap: advanced telescopes and observatories

NASA Technical Reports Server (NTRS)

Feinberg, Lee D.

2005-01-01

The NASA Advanced Telescopes and Observatories (ATO) Capability Roadmap addresses technologies necessary for NASA to enable future space telescopes and observatories collecting all electromagnetic bands, ranging from x-rays to millimeter waves, and including gravity-waves. It has derived capability priorities from current and developing Space Missions Directorate (SMD) strategic roadmaps and, where appropriate, has ensured their consistency with other NASA Strategic and Capability Roadmaps. Technology topics include optics; wavefront sensing and control and interferometry; distributed and advanced spacecraft systems; cryogenic and thermal control systems; large precision structure for observatories; and the infrastructure essential to future space telescopes and observatories.

From vision to action: roadmapping as a strategic method and tool to implement climate change adaptation - the example of the roadmap 'water sensitive urban design 2020'.

PubMed

Hasse, J U; Weingaertner, D E

2016-01-01

As the central product of the BMBF-KLIMZUG-funded Joint Network and Research Project (JNRP) 'dynaklim - Dynamic adaptation of regional planning and development processes to the effects of climate change in the Emscher-Lippe region (North Rhine Westphalia, Germany)', the Roadmap 2020 'Regional Climate Adaptation' has been developed by the various regional stakeholders and institutions containing specific regional scenarios, strategies and adaptation measures applicable throughout the region. This paper presents the method, elements and main results of this regional roadmap process by using the example of the thematic sub-roadmap 'Water Sensitive Urban Design 2020'. With a focus on the process support tool 'KlimaFLEX', one of the main adaptation measures of the WSUD 2020 roadmap, typical challenges for integrated climate change adaptation like scattered knowledge, knowledge gaps and divided responsibilities but also potential solutions and promising chances for urban development and urban water management are discussed. With the roadmap and the related tool, the relevant stakeholders of the Emscher-Lippe region have jointly developed important prerequisites to integrate their knowledge, to clarify vulnerabilities, adaptation goals, responsibilities and interests, and to foresightedly coordinate measures, resources, priorities and schedules for an efficient joint urban planning, well-grounded decision-making in times of continued uncertainties and step-by-step implementation of adaptation measures from now on.

A Roadmap for Implementation of Blended Learning at the School Level: A Case Study of the iLearnNYC Lab Schools

ERIC Educational Resources Information Center

Darrow, Rob; Friend, Bruce; Powell, Allison

2013-01-01

This roadmap was designed to provide guidance to the New York City Department of Education (NYCDOE) school administrators in implementing blended learning programs in their own schools. Over the 2012-13 school year, the International Association for K-12 Online Learning (iNACOL) worked with 8 NYCDOE Lab Schools, each with its own blended learning…

Accurate and reproducible functional maps in 127 human cell types via 2D genome segmentation

PubMed Central

Hardison, Ross C.

2017-01-01

Abstract The Roadmap Epigenomics Consortium has published whole-genome functional annotation maps in 127 human cell types by integrating data from studies of multiple epigenetic marks. These maps have been widely used for studying gene regulation in cell type-specific contexts and predicting the functional impact of DNA mutations on disease. Here, we present a new map of functional elements produced by applying a method called IDEAS on the same data. The method has several unique advantages and outperforms existing methods, including that used by the Roadmap Epigenomics Consortium. Using five categories of independent experimental datasets, we compared the IDEAS and Roadmap Epigenomics maps. While the overall concordance between the two maps is high, the maps differ substantially in the prediction details and in their consistency of annotation of a given genomic position across cell types. The annotation from IDEAS is uniformly more accurate than the Roadmap Epigenomics annotation and the improvement is substantial based on several criteria. We further introduce a pipeline that improves the reproducibility of functional annotation maps. Thus, we provide a high-quality map of candidate functional regions across 127 human cell types and compare the quality of different annotation methods in order to facilitate biomedical research in epigenomics. PMID:28973456

DOE Office of Scientific and Technical Information (OSTI.GOV)

Werling, Eric

This report presents the Building America Research-to-Market Plan (Plan), including the integrated Building America Technology-to-Market Roadmaps (Roadmaps) that will guide Building America’s research, development, and deployment (RD&D) activities over the coming years. The Plan and Roadmaps will be updated as necessary to adapt to research findings and evolving stakeholder needs, and they will reflect input from DOE and stakeholders.

Neglected tropical diseases: progress towards addressing the chronic pandemic.

PubMed

Molyneux, David H; Savioli, Lorenzo; Engels, Dirk

2017-01-21

The concept of neglected tropical diseases (NTDs) emerged more than a decade ago and has been recognised as a valid way to categorise diseases that affect the poorest individuals. Substantial progress in control and elimination has been achieved and policy momentum has been generated through continued bilateral, philanthropic, and non-governmental development organisation (NGDO) support, and donations of drugs from pharmaceutical companies. WHO has defined a Roadmap to reach 2020 targets, which was endorsed by member states in a World Health Assembly Resolution in 2013. NTDs have been included within the Sustainable Development Goal targets and are a crucial component of universal health coverage, conceptualised as "leaving no one behind". WHO reported that more than 1 billion people in 88 countries have benefited from preventive chemotherapy in 2014. The research agenda has defined the need for affordable products (diagnostics, drugs and insecticides). However challenges such as insecurity and weak health systems continue to prevail in the poorest countries, inhibiting progress in scaling up and also in achieving Roadmap goals. Copyright © 2017 Elsevier Ltd. All rights reserved.

The COSPAR roadmap on Space-based observation and Integrated Earth System Science for 2016-2025

NASA Astrophysics Data System (ADS)

Fellous, Jean-Louis

2016-07-01

The Committee on Space Research of the International Council for Science recently commissioned a study group to prepare a roadmap on observation and integrated Earth-system science for the coming ten years. Its focus is on the combined use of observations and modelling to address the functioning, predictability and projected evolution of the Earth system on timescales out to a century or so. It discusses how observations support integrated Earth-system science and its applications, and identifies planned enhancements to the contributing observing systems and other requirements for observations and their processing. The paper will provide an overview of the content of the roadmap. All types of observation are considered in the roadmap, but emphasis is placed on those made from space. The origins and development of the integrated view of the Earth system are outlined, noting the interactions between the main components that lead to requirements for integrated science and modelling, and for the observations that guide and support them. What constitutes an Earth-system model is discussed. Summaries are given of key cycles within the Earth system. The nature of Earth observation and the arrangements for international coordination essential for effective operation of global observing systems are introduced in the roadmap. Instances are given of present types of observation, what is already on the roadmap for 2016-2025 and some of the issues to be faced. The current status and prospects for Earth-system modelling are summarized. Data assimilation is discussed not only because it uses observations and models to generate datasets for monitoring the Earth system and for initiating and evaluating predictions, in particular through reanalysis, but also because of the feedback it provides on the quality of both the observations and the models employed. Finally the roadmap offers a set of concluding discussions covering general developmental needs, requirements for continuity of space-based observing systems, further long-term requirements for observations and other data, technological advances and data challenges, and the importance of enhanced international cooperation.

Embracing Complexity of Crop Phytobiomes with a Multidisciplinary Roadmap for Phytobiomes Research and an Industry-Academic Research Alliance

NASA Astrophysics Data System (ADS)

Eversole, K.

2016-12-01

To meet the demands of a global human population expected to exceed 9.6 billion by 2055, crop productivity in sustainable agricultural systems must improve considerably in the face of a steadily changing climate and increased biotic and abiotic stressors. Traditional agricultural sciences have relied mostly on research within individual disciplines and linear, reductionist approaches for crop improvement. While significant advancements have been made in developing and characterizing genetic and genomic resources for crops, we still have a very limited understanding of genotype by environment x management (GxExM) interactions that determine productivity, sustainability, quality, and the ability to withstand biotic and abiotic stressors. Embracing complexity and the non-linear organization and regulation of biological systems would enable a paradigm shift in breeding and crop production by allowing us to move towards a holistic, systems level approach that integrates a wide range of disciplines (e.g., geophysics, biology, agronomy, physiology, genomics, genetics, breeding, physics, pattern recognition, feedback loops, modeling, and engineering) and knowledge about crop phytobiomes (i.e., plants, their associated macro- and micro-organisms, and the geophysical environment of distinct geographical sites). By focusing on the phytobiome, we will be able to elucidate, quantify, model, predict, act, manipulate, and prevent and ultimately prescribe the cropping systems, methods, and management practices most suited for a particular farm, grassland, or forest. The recently released, multidisciplinary roadmap entitled Phytobiomes: A Roadmap for Research and Translation and the new International Alliance for Phytobiomes Research, an industry-academic consortium, will be presented.

NASA Capability Roadmaps Executive Summary

NASA Technical Reports Server (NTRS)

Willcoxon, Rita; Thronson, Harley; Varsi, Guilio; Mueller, Robert; Regenie, Victoria; Inman, Tom; Crooke, Julie; Coulter, Dan

2005-01-01

This document is the result of eight months of hard work and dedication from NASA, industry, other government agencies, and academic experts from across the nation. It provides a summary of the capabilities necessary to execute the Vision for Space Exploration and the key architecture decisions that drive the direction for those capabilities. This report is being provided to the Exploration Systems Architecture Study (ESAS) team for consideration in development of an architecture approach and investment strategy to support NASA future mission, programs and budget requests. In addition, it will be an excellent reference for NASA's strategic planning. A more detailed set of roadmaps at the technology and sub-capability levels are available on CD. These detailed products include key driving assumptions, capability maturation assessments, and technology and capability development roadmaps.

Rapid Cost Assessment of Space Mission Concepts Through Application of Complexity-Based Cost Indices

NASA Technical Reports Server (NTRS)

Peterson, Craig E.; Cutts, James; Balint, Tibor; Hall, James B.

2008-01-01

This slide presentation reviews the development of a rapid cost assessment models for evaluation of exploration missions through the application of complexity based cost indices. In Fall of 2004, NASA began developing 13 documents, known as "strategic roadmaps," intended to outline a strategy for space exploration over the next 30 years. The Third Strategic Roadmap, The Strategic Roadmap for Solar System Exploration, focused on strategy for robotic exploration of the Solar System. Development of the Strategic Roadmap for Solar System Exploration led to the investigation of a large variety of missions. However, the necessity of planning around scientific inquiry and budgetary constraints made it necessary for the roadmap development team to evaluate potential missions not only for scientific return but also cost. Performing detailed cost studies for each of the large number of missions was impractical given the time constraints involved and lack of detailed mission studies; so a method of rapid cost assessment was developed by us to allow preliminary analysis. It has been noted that there is a strong correlation between complexity and cost and schedule of planetary missions. While these correlations were made after missions had been built and flown (successfully or otherwise), it seemed likely that a similar approach could provide at least some relative cost ranking. Cost estimation relationships (CERs) have been developed based on subsystem design choices. These CERs required more detailed information than available, forcing the team to adopt a more high level approach. Costing by analogy has been developed for small satellites, however, planetary exploration missions provide such varying spacecraft requirements that there is a lack of adequately comparable missions that can be used for analogy.

TA-13: Ground and Launch Systems, 2015 NASA Technology Roadmaps

NASA Technical Reports Server (NTRS)

Fox, Jack J.

2015-01-01

This presentation is a summary of new content contained in the 2015 update of Technology Area-13, Ground and Launch Systems technology roadmap beyond the content contained in the 2010 version. Also included are brief assessments of benefits, alignments, challenges, technical risk and reasonableness, sequencing and timing, and time and effort to achieve goals. This presentation is part of overall presentations of new content only for the 2015 update of the 15 NASA Technology Roadmaps that will be conducted in a public forum managed by the National Research Council on September 28-29, 2015. The 15 roadmaps have already been publically released via the STI process.

The 2017 Plasma Roadmap: Low temperature plasma science and technology

DOE PAGES

Adamovich, I.; Baalrud, S. D.; Bogaerts, A.; ...

2017-07-14

Journal of Physics D: Applied Physics published the first Plasma Roadmap in 2012 consisting of the individual perspectives of 16 leading experts in the various sub-fields of low temperature plasma science and technology. The 2017 Plasma Roadmap is the first update of a planned series of periodic updates of the Plasma Roadmap. The continuously growing interdisciplinary nature of the low temperature plasma field and its equally broad range of applications are making it increasingly difficult to identify major challenges that encompass all of the many sub-fields and applications. This intellectual diversity is ultimately a strength of the field. The currentmore » state of the art for the 19 sub-fields addressed in this roadmap demonstrates the enviable track record of the low temperature plasma field in the development of plasmas as an enabling technology for a vast range of technologies that underpin our modern society. At the same time, the many important scientific and technological challenges shared in this roadmap show that the path forward is not only scientifically rich but has the potential to make wide and far reaching contributions to many societal challenges.« less

The 2017 Plasma Roadmap: Low temperature plasma science and technology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adamovich, I.; Baalrud, S. D.; Bogaerts, A.

Journal of Physics D: Applied Physics published the first Plasma Roadmap in 2012 consisting of the individual perspectives of 16 leading experts in the various sub-fields of low temperature plasma science and technology. The 2017 Plasma Roadmap is the first update of a planned series of periodic updates of the Plasma Roadmap. The continuously growing interdisciplinary nature of the low temperature plasma field and its equally broad range of applications are making it increasingly difficult to identify major challenges that encompass all of the many sub-fields and applications. This intellectual diversity is ultimately a strength of the field. The currentmore » state of the art for the 19 sub-fields addressed in this roadmap demonstrates the enviable track record of the low temperature plasma field in the development of plasmas as an enabling technology for a vast range of technologies that underpin our modern society. At the same time, the many important scientific and technological challenges shared in this roadmap show that the path forward is not only scientifically rich but has the potential to make wide and far reaching contributions to many societal challenges.« less

Developing a Roadmap for Improving Neglected and Underutilized Crops: A Case Study of South Africa

PubMed Central

Mabhaudhi, Tafadzwanashe; Chimonyo, Vimbayi G. P.; Chibarabada, Tendai P.; Modi, Albert T.

2017-01-01

Reports of neglected and underutilized crops' (NUS) potential remain mostly anecdotal with limited and often incoherent research available to support them. This has been attributed to lack of clear research goals, limited funding directed at NUS and journal apathy toward publishing work on NUS. The latter points also explain the lack of interest from emerging and established researchers. Additionally, the NUS community's inability to articulate a roadmap for NUS' promotion may have unintentionally contributed to this. The current study is a sequel to an initial study that assessed the status of NUS in South Africa. The objective of this follow-up study was then to (i) identify priority NUS, and (ii) articulate a strategy and actionable recommendations for promoting NUS in South Africa. The study identified 13 priority NUS, categorized into cereals, legumes, root, and tuber crops and leafy vegetables based on drought and heat stress tolerance and nutritional value. It is recommended that the available limited resources should be targeted on improving these priority NUS as they offer the best prospects for success. Focus should be on developing value chains for the priority NUS. This should be underpinned by science to provide evidence-based outcomes. This would assist to attract more funding for NUS research, development and innovation in South Africa. It is envisaged that through this roadmap, NUS could be transformed from the peripheries into mainstream agriculture. This study provides a template for developing a roadmap for promoting NUS that could be transposed and replicated among the 14 other southern African states. PMID:29312397

NASA Strategic Roadmap Summary Report

NASA Technical Reports Server (NTRS)

Wilson, Scott; Bauer, Frank; Stetson, Doug; Robey, Judee; Smith, Eric P.; Capps, Rich; Gould, Dana; Tanner, Mike; Guerra, Lisa; Johnston, Gordon

2005-01-01

In response to the Vision, NASA commissioned strategic and capability roadmap teams to develop the pathways for turning the Vision into a reality. The strategic roadmaps were derived from the Vision for Space Exploration and the Aldrich Commission Report dated June 2004. NASA identified 12 strategic areas for roadmapping. The Agency added a thirteenth area on nuclear systems because the topic affects the entire program portfolio. To ensure long-term public visibility and engagement, NASA established a committee for each of the 13 areas. These committees - made up of prominent members of the scientific and aerospace industry communities and senior government personnel - worked under the Federal Advisory Committee Act. A committee was formed for each of the following program areas: 1) Robotic and Human Lunar Exploration; 2) Robotic and Human Exploration of Mars; 3) Solar System Exploration; 4) Search for Earth-Like Planets; 5) Exploration Transportation System; 6) International Space Station; 7) Space Shuttle; 8) Universe Exploration; 9) Earth Science and Applications from Space; 10) Sun-Solar System Connection; 11) Aeronautical Technologies; 12) Education; 13) Nuclear Systems. This document contains roadmap summaries for 10 of these 13 program areas; The International Space Station, Space Shuttle, and Education are excluded. The completed roadmaps for the following committees: Robotic and Human Exploration of Mars; Solar System Exploration; Search for Earth-Like Planets; Universe Exploration; Earth Science and Applications from Space; Sun-Solar System Connection are collected in a separate Strategic Roadmaps volume. This document contains memebership rosters and charters for all 13 committees.

Cost-Reduction Roadmap Outlines Two Pathways to Meet DOE Residential Solar

Science.gov Websites

Cost Target for 2030 | News | NREL Cost-Reduction Roadmap Outlines Two Pathways to Meet DOE Residential Solar Cost Target for 2030 News Release: Cost-Reduction Roadmap Outlines Two Pathways to Meet DOE Residential Solar Cost Target for 2030 Installing photovoltaics at the time of roof replacement or as part of

Promising roadmap alternatives for the SpaceLiner

NASA Astrophysics Data System (ADS)

Sippel, Martin

2010-06-01

The paper describes the vision and potential roadmap alternatives of an ultrafast intercontinental passenger transport based on a rocket powered two-stage reusable vehicle. An operational scenario and the latest technical lay-out of the configuration's preliminary design including flight performance are described. The question of how the revolutionary ultrafast transport can be realized is addressed by an assessment of the different technological and programmatic roadmap alternatives.

Prognostic factors, predictive markers and cancer biology: the triad for successful oral cancer chemoprevention.

PubMed

Monteiro de Oliveira Novaes, Jose Augusto; William, William N

2016-10-01

Oral squamous cell carcinomas represent a significant cancer burden worldwide. Unfortunately, chemoprevention strategies investigated to date have failed to produce an agent considered standard of care to prevent oral cancers. Nonetheless, recent advances in clinical trial design may streamline drug development in this setting. In this manuscript, we review some of these improvements, including risk prediction tools based on molecular markers that help select patients most suitable for chemoprevention. We also discuss the opportunities that novel preclinical models and modern molecular profiling techniques will bring to the prevention field in the near future, and propose a clinical trials framework that incorporates molecular prognostic factors, predictive markers and cancer biology as a roadmap to improve chemoprevention strategies for oral cancers.

Roadmap to quieter highways

NASA Astrophysics Data System (ADS)

Corbisier, Christopher

2005-09-01

Research in Europe, as documented by an FHWA/AASHTO European Scan Tour held in May 2004, and recent activity in Arizona and California, has fostered much interest in ``quiet pavements.'' On September 14-16, 2004, an FHWA sponsored Roadmap to Quieter Highways workshop was held at Purdue University. Participants were from the disciplines of pavement, safety, and noise from FHWA, State departments of transportation, industry (paving associations, general contractors, tire, and vehicle manufacturers), and academia. After several breakout sessions in the areas of policy, construction, maintenance, analysis (measurement and prediction), research, and design, the group had identified the knowledge gaps and developed a plan to fill those gaps. Several activities have been implemented based on the Roadmap to Quieter Highways. An Expert Task Group was formed to provide a draft provisional standard for the measurement methodologies, e.g., source, wayside, pavement absorption. A Tire/Pavement 101 workshop is being developed to educate pavement practitioners in noise concepts and noise practitioners in pavement concepts. A Tire/Pavement Noise clearinghouse is being developed as a one-stop location for all current tire/pavement noise or quiet pavement activities. Several research studies have been started and a second workshop will be held in 2006 to assess progress of the Roadmap.

Establishment of the roadmap for chlorination process development for zirconium recovery and recycle

DOE Office of Scientific and Technical Information (OSTI.GOV)

Collins, E.D.; Del Cul, G.D.; Spencer, B.B.

Process development studies are being conducted to recover, purify, and reuse the zirconium (about 98.5% by mass) in used nuclear fuel (UNF) zirconium alloy cladding. Feasibility studies began in FY 2010 using empty cladding hulls that were left after fuel dissolution or after oxidation to a finely divided oxide powder (voloxidation). In FY 2012, two industrial teams (AREVA and Shaw-Westinghouse) were contracted by the Department of Energy Office of Nuclear Energy (NE) to provide technical assistance to the project. In FY 2013, the NE Fuel Cycle Research and Development Program requested development of a technology development roadmap to guide futuremore » work. The first step in the roadmap development was to assess the starting point, that is, the current state of the technology and the end goal. Based on previous test results, future work is to be focused on first using chlorine as the chlorinating agent and secondly on the use of a process design that utilizes a chlorination reactor and dual ZrCl{sub 4} product salt condensers. The likely need for a secondary purification step was recognized. Completion of feasibility testing required an experiment on the chemical decladding flowsheet option. This was done during April 2013. The roadmap for process development will continue through process chemistry optimization studies, the chlorinated reactor design configuration, product salt condensers, and the off-gas trapping of tritium or other volatile fission products from the off-gas stream. (authors)« less

The Human Space Life Sciences Critical Path Roadmap Project: A Strategy for Human Space Flight through Exploration-Class Missions

NASA Technical Reports Server (NTRS)

Sawin, Charles F.

1999-01-01

The product of the critical path roadmap project is an integrated strategy for mitigating the risks associated with human exploration class missions. It is an evolving process that will assure the ability to communicate the integrated critical path roadmap. Unlike previous reports, this one will not sit on a shelf - it has the full support of the JSC Space and Life Sciences Directorate (SA) and is already being used as a decision making tool (e.g., budget and investigation planning for Shuttle and Space Station mission). Utility of this product depends on many efforts, namely: providing the required information (completed risk data sheets, critical question information, technology data). It is essential to communicate the results of the critical path roadmap to the scientific community - this meeting is a good opportunity to do so. The web site envisioned for the critical path roadmap will provide the capability to communicate to a broader community and to track and update the system routinely.

The OPTICON technology roadmap for optical and infrared astronomy

NASA Astrophysics Data System (ADS)

Cunningham, Colin; Melotte, David; Molster, Frank

2010-07-01

The Key Technology Network (KTN) within the OPTICON programme has been developing a roadmap for the technology needed to meet the challenges of optical and infrared astronomy over the next few years, with particular emphasis on the requirements of Extremely Large Telescopes. The process and methodology so far will be described, along with the most recent roadmap. The roadmap shows the expected progression of ground-based astronomy facilities and the technological developments which will be required to realise these new facilities. The roadmap highlights the key stages in the development of these technologies. In some areas, such as conventional optics, gradual developments in areas such as light-weighting of optics will slowly be adopted into future instruments. In other areas, such as large area IR detectors, more rapid progress can be expected as new processing techniques allow larger and faster arrays. Finally, other areas such as integrated photonics have the potential to revolutionise astronomical instrumentation. Future plans are outlined, in particular our intention to look at longer term development and disruptive technologies.

NASA Strategic Roadmap: Origin, Evolution, Structure, and Destiny of the Universe

NASA Technical Reports Server (NTRS)

White, Nicholas E.

2005-01-01

The NASA strategic roadmap on the Origin, Evolution, Structure and Destiny of the Universe is one of 13 roadmaps that outline NASA s approach to implement the vision for space exploration. The roadmap outlines a program to address the questions: What powered the Big Bang? What happens close to a Black Hole? What is Dark Energy? How did the infant universe grow into the galaxies, stars and planets, and set the stage for life? The roadmap builds upon the currently operating and successful missions such as HST, Chandra and Spitzer. The program contains two elements, Beyond Einstein and Pathways to Life, performed in three phases (2005-2015, 2015-2025 and >2025) with priorities set by inputs received from reviews undertaken by the National Academy of Sciences and technology readiness. The program includes the following missions: 2005-2015 GLAST, JWST and LISA; 2015-2025 Constellation-X and a series of Einstein Probes; and >2025 a number of ambitious vision missions which will be prioritized by results from the previous two phases.

Roadmap on semiconductor-cell biointerfaces

NASA Astrophysics Data System (ADS)

Tian, Bozhi; Xu, Shuai; Rogers, John A.; Cestellos-Blanco, Stefano; Yang, Peidong; Carvalho-de-Souza, João L.; Bezanilla, Francisco; Liu, Jia; Bao, Zhenan; Hjort, Martin; Cao, Yuhong; Melosh, Nicholas; Lanzani, Guglielmo; Benfenati, Fabio; Galli, Giulia; Gygi, Francois; Kautz, Rylan; Gorodetsky, Alon A.; Kim, Samuel S.; Lu, Timothy K.; Anikeeva, Polina; Cifra, Michal; Krivosudský, Ondrej; Havelka, Daniel; Jiang, Yuanwen

2018-05-01

This roadmap outlines the role semiconductor-based materials play in understanding the complex biophysical dynamics at multiple length scales, as well as the design and implementation of next-generation electronic, optoelectronic, and mechanical devices for biointerfaces. The roadmap emphasizes the advantages of semiconductor building blocks in interfacing, monitoring, and manipulating the activity of biological components, and discusses the possibility of using active semiconductor-cell interfaces for discovering new signaling processes in the biological world.

Solar Sail Roadmap Mission GN and C Challenges

NASA Technical Reports Server (NTRS)

Heaton, Andrew F.

2005-01-01

The NASA In-Space Propulsion program is funding development work for solar sails to enhance future scientific opportunities. Key to this effort are scientific solar sail roadmap missions identified by peer review. The two near-term missions of interest are L1 Diamond and Solar Polar Imager. Additionally, the New Millennium Program is sponsoring the Space Technology 9 (ST9) demonstration mission. Solar sails are one of five technologies competing for the ST9 flight demonstration. Two candidate solar sail missions have been identified for a potential ST9 flight. All the roadmap missions and candidate flight demonstration missions face various GN&C challenges. A variety of efforts are underway to address these challenges. These include control actuator design and testing, low thrust optimization studies, attitude control system design and modeling, control-structure interaction studies, trajectory control design, and solar radiation pressure model development. Here we survey the various efforts underway and identify a few of specific recent interest and focus.

A Roadmap for Thermal Metrology

NASA Astrophysics Data System (ADS)

Bojkovski, J.; Fischer, J.; Machin, G.; Pavese, F.; Peruzzi, A.; Renaot, E.; Tegeler, E.

2009-02-01

A provisional roadmap for thermal metrology was developed in Spring 2006 as part of the EUROMET iMERA activity toward increasing impact from national investment in European metrology R&D. This consisted of two parts: one addressing the influence of thermal metrology on society, industry, and science, and the other specifying the requirements of enabling thermal metrology to serve future needs. The roadmap represents the shared vision of the EUROMET TC Therm committee as to how thermal metrology should develop to meet future requirements over the next 15 years. It is important to stress that these documents are a first attempt to roadmap the whole of thermal metrology and will certainly need regular review and revision to remain relevant and useful to the community they seek to serve. The first part of the roadmap, “Thermal metrology for society, industry, and science,” identifies the main social and economic triggers driving developments in thermal metrology—notably citizen safety and security, new production technologies, environment and global climate change, energy, and health. Stemming from these triggers, key targets are identified that require improved thermal measurements. The second part of the roadmap, “Enabling thermal metrology to serve future needs” identifies another set of triggers, like global trade and interoperability, future needs in transport, and the earth radiation budget. Stemming from these triggers, key targets are identified, such as improved realizations and dissemination of the SI unit the kelvin, anchoring the kelvin to the Boltzmann constant, k B, and calculating thermal properties from first principles. To facilitate these outcomes, the roadmap identifies the technical advances required in thermal measurement standards.

Evaluation of Roadmap to Achieve Energy Delivery Systems Cybersecurity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chavez, Adrian R.

The Department of Energy/Office of Electricity Delivery and Energy Reliability (DOE/OE) Cybersecurity for Energy Delivery Systems (CEDS) program is currently evaluating the Roadmap to Achieve Energy Delivery Systems Cybersecurity document that sets a vision and outlines a set of milestones. The milestones are divided into five strategic focus areas that include: 1. Build a Culture of Security; 2. Assess and Monitor Risk; 3. Develop and Implement New Protective Measures to Reduce Risk; 4. Manage Incidents; and 5. Sustain Security Improvements. The most current version of the roadmap was last updated in September of 2016. Sandia National Laboratories (SNL) has beenmore » tasked with revisiting the roadmap to update the current state of energy delivery systems cybersecurity protections. SNL is currently working with previous and current partners to provide feedback on which of the roadmap milestones have been met and to identify any preexisting or new gaps that are not addressed by the roadmap. The specific focus areas SNL was asked to evaluate are: 1. Develop and Implement New Protective Measures to Reduce Risk and 2. Sustain Security Improvements. SNL has formed an Industry Advisory Board (IAB) to assist in answering these questions. The IAB consists of previous partners on past CEDS funded efforts as well as new collaborators that have unique insights into the current state of cybersecurity within energy delivery systems. The IAB includes asset owners, utilities and vendors of control systems. SNL will continue to maintain regular communications with the IAB to provide various perspectives on potential future updates to further improve the breadth of cybersecurity coverage of the roadmap.« less

Solar System Exploration

NASA Technical Reports Server (NTRS)

2003-01-01

Contents include the following: About the roadmap. Summary of key elements. Science objectives. Mission roadmap. Technology. Research and analysis. Education and public outreach. Appendix - Road map framework.

Methodology for Constructing a Modernization Roadmap for Air Force Automatic Test Systems

DTIC Science & Technology

2012-01-01

Constructing a Modernization Roadmap for Air Force Automatic Test Systems Lionel A. Galway , Rachel Rue, James M. Masters, Ben D. Van Roo, Manuel...constructing a modernization roadmap for Air Force automatic test systems / Lionel A. Galway ... [et al.]. p. cm. Includes bibliographical...references. ISBN 978-0-8330-5899-7 (pbk. : alk. paper) 1. United States. Air Force—Weapons systems—Testing. I. Galway , Lionel A., 1950- UG633.M3445

NASA Space Technology Draft Roadmap Area 13: Ground and Launch Systems Processing

NASA Technical Reports Server (NTRS)

Clements, Greg

2011-01-01

This slide presentation reviews the technology development roadmap for the area of ground and launch systems processing. The scope of this technology area includes: (1) Assembly, integration, and processing of the launch vehicle, spacecraft, and payload hardware (2) Supply chain management (3) Transportation of hardware to the launch site (4) Transportation to and operations at the launch pad (5) Launch processing infrastructure and its ability to support future operations (6) Range, personnel, and facility safety capabilities (7) Launch and landing weather (8) Environmental impact mitigations for ground and launch operations (9) Launch control center operations and infrastructure (10) Mission integration and planning (11) Mission training for both ground and flight crew personnel (12) Mission control center operations and infrastructure (13) Telemetry and command processing and archiving (14) Recovery operations for flight crews, flight hardware, and returned samples. This technology roadmap also identifies ground, launch and mission technologies that will: (1) Dramatically transform future space operations, with significant improvement in life-cycle costs (2) Improve the quality of life on earth, while exploring in co-existence with the environment (3) Increase reliability and mission availability using low/zero maintenance materials and systems, comprehensive capabilities to ascertain and forecast system health/configuration, data integration, and the use of advanced/expert software systems (4) Enhance methods to assess safety and mission risk posture, which would allow for timely and better decision making. Several key technologies are identified, with a couple of slides devoted to one of these technologies (i.e., corrosion detection and prevention). Development of these technologies can enhance life on earth and have a major impact on how we can access space, eventually making routine commercial space access and improve building and manufacturing, and weather forecasting for example for the effect of these process improvements on our daily lives.

Achieving Equity in Physical Activity Participation: ACSM Experience and Next Steps.

PubMed

Hasson, Rebecca E; Brown, David R; Dorn, Joan; Barkley, Lisa; Torgan, Carol; Whitt-Glover, Melicia; Ainsworth, Barbara; Keith, Nicole

2017-04-01

There is clear and consistent evidence that regular physical activity is an important component of healthy lifestyles and fundamental to promoting health and preventing disease. Despite the known benefits of physical activity participation, many people in the United States remain inactive. More specifically, physical activity behavior is socially patterned with lower participation rates among women; racial/ethnic minorities; sexual minority youth; individuals with less education; persons with physical, mental, and cognitive disabilities; individuals >65 yr of age; and those living in the southeast region of the United States. Many health-related outcomes follow a pattern that is similar to physical activity participation. In response to the problem of inequities in physical activity and overall health in the United States, the American College of Sports Medicine (ACSM) has developed a national roadmap that supports achieving health equity through a physically active lifestyle. The actionable, integrated pathways that provide the foundation of ACSM's roadmap include the following: 1) communication-raising awareness of the issue and magnitude of health inequities and conveying the power of physical activity in promoting health equity; 2) education-developing educational resources to improve cultural competency for health care providers and fitness professionals as well as developing new community-based programs for lay health workers; 3) collaboration-building partnerships and programs that integrate existing infrastructures and leverage institutional knowledge, reach, and voices of public, private, and community organizations; and 4) evaluation-ensuring that ACSM attains measurable progress in reducing physical activity disparities to promote health equity. This article provides a conceptual overview of these four pathways of ACSM's roadmap, an understanding of the challenges and advantages of implementing these components, and the organizational and economic benefits of achieving health equity.

NASA In-Situ Resource Utilization Project-and Seals Challenges

NASA Technical Reports Server (NTRS)

Sacksteder, Kurt; Linne, Diane

2006-01-01

A viewgraph presentation on NASA's In-Situ Resource Utilization Project and Seals Challenges is shown. The topics include: 1) What Are Space Resources?; 2) Space Resource Utilization for Exploration; 3) ISRU Enables Affordable, Sustainable & Flexible Exploration; 4) Propellant from the Moon Could Revolutionize Space Transportation; 5) NASA ISRU Capability Roadmap Study, 2005; 6) Timeline for ISRU Capability Implementation; 7) Lunar ISRU Implementation Approach; 8) ISRU Technical-to-Mission Capability Roadmap; 9) ISRU Resources & Products of Interest; and 10) Challenging Seals Requirements for ISRU.

Urine biomarkers in the early stages of diseases: current status and perspective.

PubMed

Jing, Jian; Gao, Youhe

2018-02-01

As a noninvasive and easily available biological fluid, the urine is becoming an important source for disease biomarker study. Change is essential for the usefulness of a biomarker. Without homeostasis mechanisms, urine can accommodate more changes, especially in the early stages of diseases. In this review, we summarize current status and discuss perspectives on the discovery of urine biomarkers in the early stages of diseases. We emphasize the advantages of urine biomarkers compared to plasma biomarkers for the diagnosis of diseases at early stages, propose a urine biomarker research roadmap, and highlight a novel membrane storage technique that enables large-scale urine sample collection and storage efficiently and economically. It is anticipated that urine biomarker studies will greatly promote early diagnosis, prevention, treatment, and prognosis of a variety of diseases, and provide strong support for translational and precision medicine.

Forest Products Industry Technology Roadmap

DOE Office of Scientific and Technical Information (OSTI.GOV)

none,

2010-04-01

This document describes the forest products industry's research and development priorities. The original technology roadmap published by the industry in 1999 and was most recently updated in April 2010.

Roadmap for the international, accelerator-based neutrino programme

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cao, J.; de Gouvêa, A.; Duchesneau, D.

In line with its terms of reference the ICFA Neutrino Panel has developed a roadmap for the international, accelerator-based neutrino programme. A "roadmap discussion document" was presented in May 2016 taking into account the peer-group-consultation described in the Panel's initial report. The "roadmap discussion document" was used to solicit feedback from the neutrino community---and more broadly, the particle- and astroparticle-physics communities---and the various stakeholders in the programme. The roadmap, the conclusions and recommendations presented in this document take into account the comments received following the publication of the roadmap discussion document. With its roadmap the Panel documents the approved objectivesmore » and milestones of the experiments that are presently in operation or under construction. Approval, construction and exploitation milestones are presented for experiments that are being considered for approval. The timetable proposed by the proponents is presented for experiments that are not yet being considered formally for approval. Based on this information, the evolution of the precision with which the critical parameters governinger the neutrino are known has been evaluated. Branch or decision points have been identified based on the anticipated evolution in precision. The branch or decision points have in turn been used to identify desirable timelines for the neutrino-nucleus cross section and hadro-production measurements that are required to maximise the integrated scientific output of the programme. The branch points have also been used to identify the timeline for the R&D required to take the programme beyond the horizon of the next generation of experiments. The theory and phenomenology programme, including nuclear theory, required to ensure that maximum benefit is derived from the experimental programme is also discussed.« less

The Soils and Groundwater – EM-20 S&T Roadmap Quality Assurance Project Plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fix, N. J.

The Soils and Groundwater – EM-20 Science and Technology Roadmap Project is a U.S. Department of Energy, Office of Environmental Management-funded initiative designed to develop new methods, strategies and technology for characterizing, modeling, remediating, and monitoring soils and groundwater contaminated with metals, radionuclides, and chlorinated organics. This Quality Assurance Project Plan provides the quality assurance requirements and processes that will be followed by EM-20 Roadmap Project staff.

Building Information Modeling (BIM) Roadmap: Supplement 2 - BIM Implementation Plan for Military Construction Projects, Bentley Platform

DTIC Science & Technology

2011-01-01

ER D C TR -0 6- 10 , S up pl em en t 2 Building Information Modeling ( BIM ) Roadmap Supplement 2 – BIM Implementation Plan for Military...release; distribution is unlimited. ERDC TR-06-10, Supplement 2 January 2011 Building Information Modeling ( BIM ) Roadmap Supplement 2 – BIM ...ERDC TR-06-10, Supplement 2 (January 2011) 2 Abstract: Building Information Modeling ( BIM ) technology provides the communities of practice in

A CFD validation roadmap for hypersonic flows

NASA Technical Reports Server (NTRS)

Marvin, Joseph G.

1992-01-01

A roadmap for computational fluid dynamics (CFD) code validation is developed. The elements of the roadmap are consistent with air-breathing vehicle design requirements and related to the important flow path components: forebody, inlet, combustor, and nozzle. Building block and benchmark validation experiments are identified along with their test conditions and measurements. Based on an evaluation criteria, recommendations for an initial CFD validation data base are given and gaps identified where future experiments would provide the needed validation data.

A CFD validation roadmap for hypersonic flows

NASA Technical Reports Server (NTRS)

Marvin, Joseph G.

1993-01-01

A roadmap for computational fluid dynamics (CFD) code validation is developed. The elements of the roadmap are consistent with air-breathing vehicle design requirements and related to the important flow path components: forebody, inlet, combustor, and nozzle. Building block and benchmark validation experiments are identified along with their test conditions and measurements. Based on an evaluation criteria, recommendations for an initial CFD validation data base are given and gaps identified where future experiments would provide the needed validation data.

Biogas Opportunities Roadmap Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

In support of the Obama Administration's Climate Action Plan, the U.S. Department of Energy, the U.S. Environmental Protection Agency, and U.S. Department of Agriculture jointly released the Biogas Opportunities Roadmap Progress Report, updating the federal government's progress to reduce methane emissions through biogas systems since the Biogas Opportunities Roadmap was completed by the three agencies in July 2014. The report highlights actions taken, outlines challenges and opportunities, and identifies next steps to the growth of a robust biogas industry.

A European Roadmap for Thermophysical Properties Metrology

NASA Astrophysics Data System (ADS)

Filtz, J.-R.; Wu, J.; Stacey, C.; Hollandt, J.; Monte, C.; Hay, B.; Hameury, J.; Villamañan, M. A.; Thurzo-Andras, E.; Sarge, S.

2015-03-01

A roadmap for thermophysical properties metrology was developed in spring 2011 by the Thermophysical Properties Working Group in the EURAMET Technical Committee in charge of Thermometry, Humidity and Moisture, and Thermophysical Properties metrology. This roadmapping process is part of the EURAMET (European Association of National Metrology Institutes) activities aiming to increase impact from national investment in European metrology R&D. The roadmap shows a shared vision of how the development of thermophysical properties metrology should be oriented over the next 15 years to meet future social and economic needs. Since thermophysical properties metrology is a very broad and varied field, the authors have limited this roadmap to the following families of properties: thermal transport properties (thermal conductivity, thermal diffusivity, etc.), radiative properties (emissivity, absorbance, reflectance, and transmittance), caloric quantities (specific heat, enthalpy, etc.), thermodynamic properties (PVT and phase equilibria properties), and temperature-dependent quantities (thermal expansion, compressibility, etc.). This roadmap identifies the main societal and economical triggers that drive developments in thermophysical properties metrology. The key topics considered are energy, environment, advanced manufacturing and processing, public safety, security, and health. Key targets that require improved thermophysical properties measurements are identified in order to address these triggers. Ways are also proposed for defining the necessary skills and the main useful means to be implemented. These proposals will have to be revised as needs and technologies evolve in the future.

Considering new methodologies in strategies for safety assessment of foods and food ingredients.

PubMed

Blaauboer, Bas J; Boobis, Alan R; Bradford, Bobbie; Cockburn, Andrew; Constable, Anne; Daneshian, Mardas; Edwards, Gareth; Garthoff, Jossie A; Jeffery, Brett; Krul, Cyrille; Schuermans, Jeroen

2016-05-01

Toxicology and safety assessment are changing and require new strategies for evaluating risk that are less depending on apical toxicity endpoints in animal models and relying more on knowledge of the mechanism of toxicity. This manuscript describes a number of developments that could contribute to this change and implement this in a stepwise roadmap that can be applied for the evaluation of food and food ingredients. The roadmap was evaluated in four case studies by using literature and existing data. This preliminary evaluation was shown to be useful. However, this experience should be extended by including examples where experimental work needs to be included. To further implement these new insights in toxicology and safety assessment for the area of food and food ingredients, the recommendation is that stakeholders take action in addressing gaps in our knowledge, e.g. with regard to the applicability of the roadmap for mixtures and food matrices. Further development of the threshold of toxicological concern is needed, as well as cooperation with other sectors where similar schemes are under development. Moreover, a more comprehensive evaluation of the roadmap, also including the identification of the need for in vitro experimental work is recommended. Copyright © 2016 ILSI Europe. Published by Elsevier Ltd.. All rights reserved.

AstRoMap European Astrobiology Roadmap

PubMed Central

Horneck, Gerda; Westall, Frances; Grenfell, John Lee; Martin, William F.; Gomez, Felipe; Leuko, Stefan; Lee, Natuschka; Onofri, Silvano; Tsiganis, Kleomenis; Saladino, Raffaele; Pilat-Lohinger, Elke; Palomba, Ernesto; Harrison, Jesse; Rull, Fernando; Muller, Christian; Strazzulla, Giovanni; Brucato, John R.; Rettberg, Petra; Capria, Maria Teresa

2016-01-01

Abstract The European AstRoMap project (supported by the European Commission Seventh Framework Programme) surveyed the state of the art of astrobiology in Europe and beyond and produced the first European roadmap for astrobiology research. In the context of this roadmap, astrobiology is understood as the study of the origin, evolution, and distribution of life in the context of cosmic evolution; this includes habitability in the Solar System and beyond. The AstRoMap Roadmap identifies five research topics, specifies several key scientific objectives for each topic, and suggests ways to achieve all the objectives. The five AstRoMap Research Topics are • Research Topic 1: Origin and Evolution of Planetary Systems• Research Topic 2: Origins of Organic Compounds in Space• Research Topic 3: Rock-Water-Carbon Interactions, Organic Synthesis on Earth, and Steps to Life• Research Topic 4: Life and Habitability• Research Topic 5: Biosignatures as Facilitating Life Detection It is strongly recommended that steps be taken towards the definition and implementation of a European Astrobiology Platform (or Institute) to streamline and optimize the scientific return by using a coordinated infrastructure and funding system. Key Words: Astrobiology roadmap—Europe—Origin and evolution of life—Habitability—Life detection—Life in extreme environments. Astrobiology 16, 201–243. PMID:27003862

A molecular fragment cheminformatics roadmap for mesoscopic simulation.

PubMed

Truszkowski, Andreas; Daniel, Mirco; Kuhn, Hubert; Neumann, Stefan; Steinbeck, Christoph; Zielesny, Achim; Epple, Matthias

2014-12-01

Mesoscopic simulation studies the structure, dynamics and properties of large molecular ensembles with millions of atoms: Its basic interacting units (beads) are no longer the nuclei and electrons of quantum chemical ab-initio calculations or the atom types of molecular mechanics but molecular fragments, molecules or even larger molecular entities. For its simulation setup and output a mesoscopic simulation kernel software uses abstract matrix (array) representations for bead topology and connectivity. Therefore a pure kernel-based mesoscopic simulation task is a tedious, time-consuming and error-prone venture that limits its practical use and application. A consequent cheminformatics approach tackles these problems and provides solutions for a considerably enhanced accessibility. This study aims at outlining a complete cheminformatics roadmap that frames a mesoscopic Molecular Fragment Dynamics (MFD) simulation kernel to allow its efficient use and practical application. The molecular fragment cheminformatics roadmap consists of four consecutive building blocks: An adequate fragment structure representation (1), defined operations on these fragment structures (2), the description of compartments with defined compositions and structural alignments (3), and the graphical setup and analysis of a whole simulation box (4). The basis of the cheminformatics approach (i.e. building block 1) is a SMILES-like line notation (denoted f SMILES) with connected molecular fragments to represent a molecular structure. The f SMILES notation and the following concepts and methods for building blocks 2-4 are outlined with examples and practical usage scenarios. It is shown that the requirements of the roadmap may be partly covered by already existing open-source cheminformatics software. Mesoscopic simulation techniques like MFD may be considerably alleviated and broadened for practical use with a consequent cheminformatics layer that successfully tackles its setup subtleties and conceptual usage hurdles. Molecular Fragment Cheminformatics may be regarded as a crucial accelerator to propagate MFD and similar mesoscopic simulation techniques in the molecular sciences. Graphical abstractA molecular fragment cheminformatics roadmap for mesoscopic simulation.

5.0 Aerodynamic and Propulsive Decelerator Systems

NASA Technical Reports Server (NTRS)

Cruz, Juan R.; Powell, Richard; Masciarelli, James; Brown, Glenn; Witkowski, Al; Guernsey, Carl

2005-01-01

Contents include the following: Introduction. Capability Breakdown Structure. Decelerator Functions. Candidate Solutions. Performance and Technology. Capability State-of-the-Art. Performance Needs. Candidate Configurations. Possible Technology Roadmaps. Capability Roadmaps.

Roadmap on structured light

NASA Astrophysics Data System (ADS)

Rubinsztein-Dunlop, Halina; Forbes, Andrew; Berry, M. V.; Dennis, M. R.; Andrews, David L.; Mansuripur, Masud; Denz, Cornelia; Alpmann, Christina; Banzer, Peter; Bauer, Thomas; Karimi, Ebrahim; Marrucci, Lorenzo; Padgett, Miles; Ritsch-Marte, Monika; Litchinitser, Natalia M.; Bigelow, Nicholas P.; Rosales-Guzmán, C.; Belmonte, A.; Torres, J. P.; Neely, Tyler W.; Baker, Mark; Gordon, Reuven; Stilgoe, Alexander B.; Romero, Jacquiline; White, Andrew G.; Fickler, Robert; Willner, Alan E.; Xie, Guodong; McMorran, Benjamin; Weiner, Andrew M.

2017-01-01

Structured light refers to the generation and application of custom light fields. As the tools and technology to create and detect structured light have evolved, steadily the applications have begun to emerge. This roadmap touches on the key fields within structured light from the perspective of experts in those areas, providing insight into the current state and the challenges their respective fields face. Collectively the roadmap outlines the venerable nature of structured light research and the exciting prospects for the future that are yet to be realized.

Summary of NASA Advanced Telescope and Observatory Capability Roadmap

NASA Technical Reports Server (NTRS)

Stahl, H. Phil; Feinberg, Lee

2006-01-01

The NASA Advanced Telescope and Observatory (ATO) Capability Roadmap addresses technologies necessary for NASA to enable future space telescopes and observatories operating in all electromagnetic bands, from x-rays to millimeter waves, and including gravity-waves. It lists capability priorities derived from current and developing Space Missions Directorate (SMD) strategic roadmaps. Technology topics include optics; wavefront sensing and control and interferometry; distributed and advanced spacecraft systems; cryogenic and thermal control systems; large precision structure for observatories; and the infrastructure essential to future space telescopes and observatories.

ILEWG technology roadmap for Moon exploration

NASA Astrophysics Data System (ADS)

Foing, Bernard H.

2008-04-01

We discuss the charter and activities of the International Lunar Exploration Working Group (ILEWG), and give an update from the related ILEWG task groups. We discuss the different rationale and technology roadmap for Moon exploration, as debated in previous ILEWG conferences. The Technology rationale includes: 1) The advancement of instrumentation: 2) Technologies in robotic and human exploration 3) Moon-Mars Exploration can inspire solutions to global Earth sustained development. We finally discuss a possible roadmap for development of technologies necessary for Moon and Mars exploration.

Summary of NASA Advanced Telescope and Observatory Capability Roadmap

NASA Technical Reports Server (NTRS)

Stahl, H. Philip; Feinberg, Lee

2007-01-01

The NASA Advanced Telescope and Observatory (ATO) Capability Roadmap addresses technologies necessary for NASA to enable future space telescopes and observatories operating in all electromagnetic bands, from x-rays to millimeter waves, and including gravity-waves. It lists capability priorities derived from current and developing Space Missions Directorate (SMD) strategic roadmaps. Technology topics include optics; wavefront sensing and control and interferometry; distributed and advanced spacecraft systems; cryogenic and thermal control systems; large precision structure for observatories; and the infrastructure essential to future space telescopes and observatories.

The present status and future growth of maintenance in US manufacturing: results from a pilot survey.

PubMed

Jin, Xiaoning; Siegel, David; Weiss, Brian A; Gamel, Ellen; Wang, Wei; Lee, Jay; Ni, Jun

A research study was conducted (1) to examine the practices employed by US manufacturers to achieve productivity goals and (2) to understand what level of intelligent maintenance technologies and strategies are being incorporated into these practices. This study found that the effectiveness and choice of maintenance strategy were strongly correlated to the size of the manufacturing enterprise; there were large differences in adoption of advanced maintenance practices and diagnostics and prognostics technologies between small and medium-sized enterprises (SMEs). Despite their greater adoption of maintenance practices and technologies, large manufacturing organizations have had only modest success with respect to diagnostics and prognostics and preventive maintenance projects. The varying degrees of success with respect to preventative maintenance programs highlight the opportunity for larger manufacturers to improve their maintenance practices and use of advanced prognostics and health management (PHM) technology. The future outlook for manufacturing PHM technology among the manufacturing organizations considered in this study was overwhelmingly positive; many manufacturing organizations have current and planned projects in this area. Given the current modest state of implementation and positive outlook for this technology, gaps, future trends, and roadmaps for manufacturing PHM and maintenance strategy are presented.

The present status and future growth of maintenance in US manufacturing: results from a pilot survey

PubMed Central

Jin, Xiaoning; Siegel, David; Weiss, Brian A.; Gamel, Ellen; Wang, Wei; Lee, Jay; Ni, Jun

2016-01-01

A research study was conducted (1) to examine the practices employed by US manufacturers to achieve productivity goals and (2) to understand what level of intelligent maintenance technologies and strategies are being incorporated into these practices. This study found that the effectiveness and choice of maintenance strategy were strongly correlated to the size of the manufacturing enterprise; there were large differences in adoption of advanced maintenance practices and diagnostics and prognostics technologies between small and medium-sized enterprises (SMEs). Despite their greater adoption of maintenance practices and technologies, large manufacturing organizations have had only modest success with respect to diagnostics and prognostics and preventive maintenance projects. The varying degrees of success with respect to preventative maintenance programs highlight the opportunity for larger manufacturers to improve their maintenance practices and use of advanced prognostics and health management (PHM) technology. The future outlook for manufacturing PHM technology among the manufacturing organizations considered in this study was overwhelmingly positive; many manufacturing organizations have current and planned projects in this area. Given the current modest state of implementation and positive outlook for this technology, gaps, future trends, and roadmaps for manufacturing PHM and maintenance strategy are presented. PMID:27525253

Roadmap to Long-Term Monitoring Optimization

EPA Pesticide Factsheets

This roadmap focuses on optimization of established long-term monitoring programs for groundwater. Tools and techniques discussed concentrate on methods for optimizing the monitoring frequency and spatial (three-dimensional) distribution of wells ...

Research Roadmaps

EPA Pesticide Factsheets

These Roadmaps identify scientific gaps that inform the National Research Programs in the development of their Strategic Research Action Plans. EPA expects to use this approach to integrate existing research efforts and to identify needed work.

United Nations convention on the rights of persons with disabilities: a roadmap for change.

PubMed

Stuart, Heather

2012-09-01

This study considers the United Nations Convention on the Rights of Persons with Disabilities as a tool for promoting the full social inclusion of people with a mental or intellectual disability. The United Nations Convention has ushered in a new era of discourse that moves beyond a consideration of individual impairments, to focus on the social and environmental barriers that prevent full and effective social participation of people with disabilities. It provides an important social justice framework to guide and integrate disability policy within and across countries. In order to realize its potential, the mental health community must now actively develop a new disability discourse - one that moves beyond the traditional focus on negative protections, such as against forced confinement or coercive treatment, to one that examines the services and supports that are needed to allow people who have a mental illness to become fully functioning members of society. To meet the monitoring requirements of the Convention, the mental health community must actively seek population data to assess the nature of prejudice and discrimination experienced by people with a mental illness. An approach used by Statistics Canada is provided as one such example. The United Nations Convention is an important roadmap for change, which can be used to shift current mental health discourse from a discussion emphasizing the protection of negative rights, such as from involuntary detention or coerced treatment, to one emphasizing social rights and civic participation.

Autonomy @ Ames

NASA Technical Reports Server (NTRS)

Van Dalsem, William; Krishnakumar, Kalmanje Srinivas

2016-01-01

This is a powerpoint presentation that highlights autonomy across the 15 NASA technology roadmaps, including specific examples of projects (past and present) at NASA Ames Research Center. The NASA technology roadmaps are located here: http:www.nasa.govofficesocthomeroadmapsindex.html

Lunar Capabilities Roadmap

NASA Astrophysics Data System (ADS)

Kramer, G. Y.; Lawrence, D. J.; Neal, C. R.; Clark, P. E.; Green, R. O.; Horanyi, M.; Johnson, M. D.; Kelso, R. M.; Sultana, M.; Thompson, D. R.

2016-11-01

A Lunar Capabilities Roadmap (LCR) is required to highlight capabilities critical for science and exploration of the Moon as well as beyond. The LCR will focus mainly on capabilities with examples of specific technologies to satisfy those needs.

Development of the INEEL Site Wide Vadose Zone Roadmap

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yonk, Alan Keith

2001-09-01

The INEEL Vadose Zone Roadmap was developed to identify inadquacies in current knowledge, to assist in contaminant management capabilities relative to the INEEL vadose zone, and to ensure that ongoing and planned Science and Technology developments will meet the risk management challenges facing the INEEL in coming years. The primary objective of the Roadmap is to determine the S&T needs that will facilitate monitoring, characterization, prediction, and assessment activities necessary to support INEEL risk management decisions and to ensure that long-term stewardship of contaminated sites at the INEEL is achieved. The mission of the Roadmap is to insure that themore » long-term S&T strategy is aligned with site programs, that it takes advantage of progress made to date, and that it can assist in meeting the milestones and budgets of operations.« less

Lunar Surface Systems Supportability Technology Development Roadmap

NASA Technical Reports Server (NTRS)

Oeftering, Richard C.; Struk, Peter M.; Green, Jennifer L.; Chau, Savio N.; Curell, Philip C.; Dempsey, Cathy A.; Patterson, Linda P.; Robbins, William; Steele, Michael A.; DAnnunzio, Anthony;

Technology Roadmaps for Compound Semiconductors

PubMed Central

Bennett, Herbert S.

2000-01-01

The roles cited for compound semiconductors in public versions of existing technology roadmaps from the National Electronics Manufacturing Initiative, Inc., Optoelectronics Industry Development Association, Microelectronics Advanced Research Initiative on Optoelectronic Interconnects, and Optoelectronics Industry and Technology Development Association (OITDA) are discussed and compared within the context of trends in the Si CMOS industry. In particular, the extent to which these technology roadmaps treat compound semiconductors at the materials processing and device levels will be presented for specific applications. For example, OITDA’s Optical Communications Technology Roadmap directly connects the information demand of delivering 100 Mbit/s to the home to the requirement of producing 200 GHz heterojunction bipolar transistors with 30 nm bases and InP high electron mobility transistors with 100 nm gates. Some general actions for progress towards the proposed International Technology Roadmap for Compound Semiconductors (ITRCS) and methods for determining the value of an ITRCS will be suggested. But, in the final analysis, the value added by an ITRCS will depend on how industry leaders respond. The technical challenges and economic opportunities of delivering high quality digital video to consumers provide concrete examples of where the above actions and methods could be applied. PMID:27551615

OBPR Free Flyer draft roadmap overview

NASA Technical Reports Server (NTRS)

Israelsson, Ulf

2005-01-01

OBPR Free Flyer Roadmap Purpose is to describe the OBPR research which is enabled by a free flying spacecraft capability To illustrate how research performed on free flying spacecrafts complement current and planned OBPR ISS activities.

Cyber S&T Priority Steering Council Research Roadmap

DTIC Science & Technology

2011-11-08

Priority Steering Council Research Roadmap for the National Defense Industrial Association Disruptive Technologies Conference 8 November 2011...AVAILABILITY STATEMENT Approved for public release; distribution unlimited 13. SUPPLEMENTARY NOTES Presented at the NDIA Disruptive Technologies Conference

INTEGRATED ENVIRONMENTAL STRATEGIES HANDBOOK

EPA Science Inventory

Chapter 1: Introduction, Background, Roadmap: History and motivation behind IES, historical background, where the program is going, roadmap (brief paragraphs explaining content of each chapter and possibly the audience sector who will benefit from reading the chapter). Chapt...

Advanced Modeling, Simulation and Analysis (AMSA) Capability Roadmap Progress Review

NASA Technical Reports Server (NTRS)

Antonsson, Erik; Gombosi, Tamas

2005-01-01

Contents include the following: NASA capability roadmap activity. Advanced modeling, simulation, and analysis overview. Scientific modeling and simulation. Operations modeling. Multi-special sensing (UV-gamma). System integration. M and S Environments and Infrastructure.

Non-Hardware ("Soft") Cost-Reduction Roadmap for Residential and Small Commercial Solar Photovoltaics, 2013-2020

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ardani, K.; Seif, D.; Margolis, R.

2013-08-01

The objective of this analysis is to roadmap the cost reductions and innovations necessary to achieve the U.S. Department of Energy (DOE) SunShot Initiative's total soft-cost targets by 2020. The roadmap focuses on advances in four soft-cost areas: (1) customer acquisition; (2) permitting, inspection, and interconnection (PII); (3) installation labor; and (4) financing. Financing cost reductions are in terms of the weighted average cost of capital (WACC) for financing PV system installations, with real-percent targets of 3.0% (residential) and 3.4% (commercial).

Strategic Directions in Heliophysics Research Related to Weakly Ionized Plasmas

NASA Technical Reports Server (NTRS)

Spann, James F.

2010-01-01

In 2009, the Heliophysics Division of NASA published its triennial roadmap entitled "Heliophysics; the solar and space physics of a new era." In this document contains a science priority that is recommended that will serve as input into the recently initiated NRC Heliophysics Decadal Survey. The 2009 roadmap includes several science targets recommendations that are directly related to weakly ionized plasmas, including on entitled "Ion-Neutral Coupling in the Atmosphere." This talk will be a brief overview of the roadmap with particular focus on the science targets relevant to weakly ionized plasmas.

A Roadmap for Reducing Cardiac Device Infections: a Review of Epidemiology, Pathogenesis, and Actionable Risk Factors to Guide the Development of an Infection Prevention Program for the Electrophysiology Laboratory.

PubMed

Branch-Elliman, Westyn

2017-08-16

Cardiovascular implantable electronic device (CIED) infections are highly morbid, common, and costly, and rates are increasing (Sohail et al. Arch Intern Med 171(20):1821-8 2011; Voigt et al. J Am Coll Cardiol 48(3):590-1 2006). Factors that contribute to the development of CIED infections include patient factors (comorbid conditions, self-care, microbiome), procedural details (repeat procedure, contamination during procedure, appropriate pre-procedural prep, and antimicrobial use), environmental and organizational factors (patient safety culture, facility barriers, such as lack of space to store essential supplies, quality of environmental cleaning), and microbial factors (type of organism, virulence of organism). Each of these can be specifically targeted with infection prevention interventions. Basic prevention practices, such as administration of systemic antimicrobials prior to incision and delaying the procedure in the setting of fever or elevated INR, are helpful for day-to-day prevention of cardiac device infections. Small single-center studies provide proof-of-concept that bundled prevention interventions can reduce infections, particularly in outbreak settings. However, data regarding which prevention strategies are the most important is limited as are data regarding the optimal prevention program for day-to-day prevention (Borer et al. Infect Control Hosp Epidemiol 25(6):492-7 2004; Ahsan et al. Europace 16(10):1482-9 2014). Evolution of infection prevention programs to include ambulatory and procedural areas is crucial as healthcare delivery is increasingly provided outside of hospitals and operating rooms. The focus on traditional operating rooms and inpatient care leaves the vast majority of healthcare delivery-including cardiac device implantations in the electrophysiology laboratory-uncovered.

EURO-CARES as Roadmap for a European Sample Curation Facility

NASA Astrophysics Data System (ADS)

Brucato, J. R.; Russell, S.; Smith, C.; Hutzler, A.; Meneghin, A.; Aléon, J.; Bennett, A.; Berthoud, L.; Bridges, J.; Debaille, V.; Ferrière, L.; Folco, L.; Foucher, F.; Franchi, I.; Gounelle, M.; Grady, M.; Leuko, S.; Longobardo, A.; Palomba, E.; Pottage, T.; Rettberg, P.; Vrublevskis, J.; Westall, F.; Zipfel, J.; Euro-Cares Team

2018-04-01

EURO-CARES is a three-year multinational project funded under the European Commission Horizon2020 research program to develop a roadmap for a European Extraterrestrial Sample Curation Facility for samples returned from solar system missions.

Implementation Plan for Chemical Industry R&D Roadmap for Nanomaterials by Design

DOE Office of Scientific and Technical Information (OSTI.GOV)

none,

2006-04-01

The purpose of this effort is to develop an implementation plan to realize the vision and goals identified in the Chemical Industry R&D Roadmap for Nanomaterials By Design: From Fundamentals to Function.

Unmanned Aircraft Systems Roadmap 2005-2030

DOT National Transportation Integrated Search

2005-01-01

This document presents the Department of Defense's (DoD) roadmap for developing and employing unmanned aircraft systems over the next 25 years (2005 to 2030). It describes the missions identified by theater warfighters to which systems could be appli...

MAPSIT and a Roadmap for Lunar and Planetary Spatial Data Infrastructure

NASA Astrophysics Data System (ADS)

Radebaugh, J.; Archinal, B.; Beyer, R.; DellaGiustina, D.; Fassett, C.; Gaddis, L.; Hagerty, J.; Hare, T.; Laura, J.; Lawrence, S. J.; Mazarico, E.; Naß, A.; Patthoff, A.; Skinner, J.; Sutton, S.; Thomson, B. J.; Williams, D.

2017-10-01

We describe MAPSIT, and the development of a roadmap for lunar and planetary SDI, based on previous relevant documents and community input, and consider how to best advance lunar science, exploration, and commercial development.

EV Charging Infrastructure Roadmap

DOE Office of Scientific and Technical Information (OSTI.GOV)

Karner, Donald; Garetson, Thomas; Francfort, Jim

2016-08-01

As highlighted in the U.S. Department of Energy’s EV Everywhere Grand Challenge, vehicle technology is advancing toward an objective to “… produce plug-in electric vehicles that are as affordable and convenient for the average American family as today’s gasoline-powered vehicles …” [1] by developing more efficient drivetrains, greater battery energy storage per dollar, and lighter-weight vehicle components and construction. With this technology advancement and improved vehicle performance, the objective for charging infrastructure is to promote vehicle adoption and maximize the number of electric miles driven. The EV Everywhere Charging Infrastructure Roadmap (hereafter referred to as Roadmap) looks forward and assumesmore » that the technical challenges and vehicle performance improvements set forth in the EV Everywhere Grand Challenge will be met. The Roadmap identifies and prioritizes deployment of charging infrastructure in support of this charging infrastructure objective for the EV Everywhere Grand Challenge« less

X-43D Conceptual Design and Feasibility Study

NASA Technical Reports Server (NTRS)

Johnson, Donald B.; Robinson, Jeffrey S.

2005-01-01

NASA s Next Generation Launch Technology (NGLT) Program, in conjunction with the office of the Director of Defense Research and Engineering (DDR&E), developed an integrated hypersonic technology demonstration roadmap. This roadmap is an integral part of the National Aerospace Initiative (NAI), a multi-year, multi-agency cooperative effort to invest in and develop, among other things, hypersonic technologies. This roadmap contains key ground and flight demonstrations required along the path to developing a reusable hypersonic space access system. One of the key flight demonstrations required for systems that will operate in the high Mach number regime is the X-43D. As currently conceived, the X-43D is a Mach 15 flight test vehicle that incorporates a hydrogen-fueled scramjet engine. The purpose of the X-43D is to gather high Mach number flight environment and engine operability information which is difficult, if not impossible, to gather on the ground. During 2003, the NGLT Future Hypersonic Flight Demonstration Office initiated a feasibility study on the X-43D. The objective of the study was to develop a baseline conceptual design, assess its performance, and identify the key technical issues. The study also produced a baseline program plan, schedule, and cost, along with a list of key programmatic risks.

An Evolved International Lunar Decade Global Exploration Roadmap

NASA Astrophysics Data System (ADS)

Dunlop, D.; Holder, K.

2015-10-01

An Evolved Global Exploration Roadmap (GER) reflecting a proposed International Lunar Decade is presented by an NSS chapter to address many of the omissions and new prospective commercial mission developments since the 2013 edition of the ISECG GER.

Seven key actions to eradicate rheumatic heart disease in Africa: the Addis Ababa communiqué.

PubMed

Watkins, David; Zuhlke, Liesl; Engel, Mark; Daniels, Rezeen; Francis, Veronica; Shaboodien, Gasnat; Kango, Mabvuto; Abul-Fadl, Azza; Adeoye, Abiodun; Ali, Sulafa; Al-Kebsi, Mohammed; Bode-Thomas, Fidelia; Bukhman, Gene; Damasceno, Albertino; Goshu, Dejuma Yadeta; Elghamrawy, Alaa; Gitura, Bernard; Haileamlak, Abraham; Hailu, Abraha; Hugo-Hamman, Christopher; Justus, Steve; Karthikeyan, Ganesan; Kennedy, Neil; Lwabi, Peter; Mamo, Yoseph; Mntla, Pindile; Sutton, Chris; Mocumbi, Ana Olga; Mondo, Charles; Mtaja, Agnes; Musuku, John; Mucumbitsi, Joseph; Murango, Louis; Nel, George; Ogendo, Stephen; Ogola, Elijah; Ojji, Dike; Olunuga, Taiwo Olabisi; Redi, Mekia Mohammed; Rusingiza, Kamanzi Emmanuel; Sani, Mahmoud; Sheta, Sahar; Shongwe, Steven; van Dam, Joris; Gamra, Habib; Carapetis, Jonathan; Lennon, Diana; Mayosi, Bongani M

Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) remain major causes of heart failure, stroke and death among African women and children, despite being preventable and imminently treatable. From 21 to 22 February 2015, the Social Cluster of the Africa Union Commission (AUC) hosted a consultation with RHD experts convened by the Pan-African Society of Cardiology (PASCAR) in Addis Ababa, Ethiopia, to develop a 'roadmap' of key actions that need to be taken by governments to eliminate ARF and eradicate RHD in Africa. Seven priority areas for action were adopted: (1) create prospective disease registers at sentinel sites in affected countries to measure disease burden and track progress towards the reduction of mortality by 25% by the year 2025, (2) ensure an adequate supply of high-quality benzathine penicillin for the primary and secondary prevention of ARF/RHD, (3) improve access to reproductive health services for women with RHD and other non-communicable diseases (NCD), (4) decentralise technical expertise and technology for diagnosing and managing ARF and RHD (including ultrasound of the heart), (5) establish national and regional centres of excellence for essential cardiac surgery for the treatment of affected patients and training of cardiovascular practitioners of the future, (6) initiate national multi-sectoral RHD programmes within NCD control programmes of affected countries, and (7) foster international partnerships with multinational organisations for resource mobilisation, monitoring and evaluation of the programme to end RHD in Africa. This Addis Ababa communiqué has since been endorsed by African Union heads of state, and plans are underway to implement the roadmap in order to end ARF and RHD in Africa in our lifetime.

The Role of Space Medicine in Management of Risk in Spaceflight

NASA Technical Reports Server (NTRS)

Clark, Jonathan B.

2001-01-01

The purpose of Space Medicine is to ensure mission success by providing quality and comprehensive health care throughout all mission phases to optimize crew health and performance and to prevent negative long-term health consequences. Space flight presents additional hazards and associated risks to crew health, performance, and safety. With an extended human presence in space it is expected that illness and injury will occur on orbit, which may present a significant threat to crew health and performance and to mission success. Maintaining crew health, safety and performance and preventing illness and injury are high priorities necessary for mission success and agency goals. Space flight health care should meet the standards of practice of evidence based clinical medicine. The function of Space Medicine is expected to meet the agency goals as stated in the 1998 NASA Strategic Plan and the priorities established by the Critical Path Roadmap Project. The Critical Path Roadmap Project is an integrated NASA cross-disciplinary strategy to assess, understand, mitigate, and manage the risks associated with long-term exposure to the space flight environment. The evidence based approach to space medicine should be standardized, objective process yielding expected results and establishing clinical practice standards while balancing individual risk with mission (programmatic) risk. The ability to methodically apply available knowledge and expertise to individual and mission health issues will ensure appropriate priorities are assigned and resources are allocated. NASA Space Medicine risk management process is a combined clinical and engineering approach. Competition for weight, power, volume, cost, and crew time must be balanced in making decisions about the care of individual crew with competing agency resources.

An ontology of and roadmap for mHealth research.

PubMed

Cameron, Joshua D; Ramaprasad, Arkalgud; Syn, Thant

2017-04-01

Mobile health or mHealth research has been growing exponentially in recent years. However, the research on mHealth has been ad-hoc and selective without a clear definition of the mHealth domain. Without a roadmap for research we may not realize the full potential of mHealth. In this paper, we present an ontological framework to define the mHealth domain and illuminate a roadmap. We present an ontology of mHealth. The ontology is developed by systematically deconstructing the domain into its primary dimensions and elements. We map the extent research on mHealth in 2014 onto the ontology and highlight the bright, light, and blind/blank spots which represent the emphasis of mHealth research. The emphases of mHealth research in 2014 are very uneven. There are a few bright spots and many light spots. The research predominantly focuses on individuals' use of mobile devices and applications to capture or obtain health-related data mostly to improve quality of care through mobile intervention. We argue that the emphases can be balanced in the roadmap for mHealth research. The ontological mapping plays an integral role in developing and maintaining the roadmap which can be updated periodically to continuously assess and guide mHealth research. Copyright © 2017 Elsevier B.V. All rights reserved.

Measurement Science for Prognostics and Health Management for Smart Manufacturing Systems: Key Findings from a Roadmapping Workshop

PubMed Central

Weiss, Brian A.; Vogl, Gregory; Helu, Moneer; Qiao, Guixiu; Pellegrino, Joan; Justiniano, Mauricio; Raghunathan, Anand

2017-01-01

The National Institute of Standards and Technology (NIST) hosted the Roadmapping Workshop – Measurement Science for Prognostics and Health Management for Smart Manufacturing Systems (PHM4SMS) in Fall 2014 to discuss the needs and priorities of stakeholders in the PHM4SMS technology area. The workshop brought together over 70 members of the PHM community. The attendees included representatives from small, medium, and large manufacturers; technology developers and integrators; academic researchers; government organizations; trade associations; and standards bodies. The attendees discussed the current and anticipated measurement science challenges to advance PHM methods and techniques for smart manufacturing systems; the associated research and development needed to implement condition monitoring, diagnostic, and prognostic technologies within manufacturing environments; and the priorities to meet the needs of PHM in manufacturing. This paper will summarize the key findings of this workshop, and present some of the critical measurement science challenges and corresponding roadmaps, i.e., suggested courses of action, to advance PHM for manufacturing. Milestones and targeted capabilities will be presented for each roadmap across three areas: PHM Manufacturing Process Techniques; PHM Performance Assessment; and PHM Infrastructure – Hardware, Software, and Integration. An analysis of these roadmaps and crosscutting themes seen across the breakout sessions is also discussed. PMID:28664163

Adoption of Electronic Health Records: A Roadmap for India

PubMed Central

2016-01-01

Objectives The objective of the study was to create a roadmap for the adoption of Electronic Health Record (EHR) in India based an analysis of the strategies of other countries and national scenarios of ICT use in India. Methods The strategies for adoption of EHR in other countries were analyzed to find the crucial steps taken. Apart from reports collected from stakeholders in the country, the study relied on the experience of the author in handling several e-health projects. Results It was found that there are four major areas where the countries considered have made substantial efforts: ICT infrastructure, Policy & regulations, Standards & interoperability, and Research, development & education. A set of crucial activities were identified in each area. Based on the analysis, a roadmap is suggested. It includes the creation of a secure health network; health information exchange; and the use of open-source software, a national health policy, privacy laws, an agency for health IT standards, R&D, human resource development, etc. Conclusions Although some steps have been initiated, several new steps need to be taken up for the successful adoption of EHR. It requires a coordinated effort from all the stakeholders. PMID:27895957

The Critical Path Roadmap Project: Biomedical Risk Reduction for Extended Spaceflight

NASA Technical Reports Server (NTRS)

Charles, John B.; Leveton, Lauren B.

2000-01-01

Human exploration of space requires an understanding of the risks to which crews will be exposed during such missions, and the mitigation of those risks to the fullest extent practical. This becomes a greater imperative as we prepare for interplanetary expeditions involving long periods in weightlessness in transit to and then from the destination (a planet, such as Mars, or perhaps a point in space, such as the Lagrangian point L2), and exposure to the unique environment of the destination itself. We need to know, more definitively, what the risks are to human health, safety, and performance, and how to prevent or counteract them throughout all phases of a long duration mission. The Johnson Space Center's Space and Life Sciences Directorate and the National Space Biomedical Research Institute (NSBRI) have implemented an effort to identify the most critical risks confronting humans on such mission and the types of research and technology efforts required to mitigate and otherwise reduce the probability and severity of those risks. This paper describes the "Critical Path Roadmap Project" to define, assess and prioritize the risks and present the results of the assessment with an emphasis on the research and technology priorities to meet the challenge of long duration human spaceflight mission.

EPA Nitrogen and Co-Pollutant Roadmap

EPA Science Inventory

Cross-media, integrated, multi-disciplinary approach to sustainably manage reactive nitrogen and co-pollutant loadings to air and water to reduce adverse impacts on the environment and human health. The goal of the Roadmap is to develop a common understanding of the Agency's rese...

Development priorities for in-space propulsion technologies

NASA Astrophysics Data System (ADS)

Johnson, Les; Meyer, Michael; Palaszewski, Bryan; Coote, David; Goebel, Dan; White, Harold

2013-02-01

During the summer of 2010, NASA's Office of Chief Technologist assembled 15 civil service teams to support the creation of a NASA integrated technology roadmap. The Aero-Space Technology Area Roadmap is an integrated set of technology area roadmaps recommending the overall technology investment strategy and prioritization for NASA's technology programs. The integrated set of roadmaps will provide technology paths needed to meet NASA's strategic goals. The roadmaps have been reviewed by senior NASA management and the National Research Council. With the exception of electric propulsion systems used for commercial communications satellite station-keeping and a handful of deep space science missions, almost all of the rocket engines in use today are chemical rockets; that is, they obtain the energy needed to generate thrust by combining reactive chemicals to create a hot gas that is expanded to produce thrust. A significant limitation of chemical propulsion is that it has a relatively low specific impulse. Numerous concepts for advanced propulsion technologies with significantly higher values of specific impulse have been developed over the past 50 years. Advanced in-space propulsion technologies will enable much more effective exploration of our solar system, near and far, and will permit mission designers to plan missions to "fly anytime, anywhere, and complete a host of science objectives at the destinations" with greater reliability and safety. With a wide range of possible missions and candidate propulsion technologies with very diverse characteristics, the question of which technologies are 'best' for future missions is a difficult one. A portfolio of technologies to allow optimum propulsion solutions for a diverse set of missions and destinations are described in the roadmap and herein.

A Lunar Surface System Supportability Technology Development Roadmap

NASA Technical Reports Server (NTRS)

Oeftering, Richard C.; Struk, Peter M.; Taleghani, Barmac K.

2009-01-01

This paper discusses the establishment of a Supportability Technology Development Roadmap as a guide for developing capabilities intended to allow NASA's Constellation program to enable a supportable, sustainable and affordable exploration of the Moon and Mars. Presented is a discussion of "supportability", in terms of space facility maintenance, repair and related logistics and a comparison of how lunar outpost supportability differs from the International Space Station. Supportability lessons learned from NASA and Department of Defense experience and their impact on a future lunar outpost is discussed. A supportability concept for future missions to the Moon and Mars that involves a transition from a highly logistics dependent to a logistically independent operation is discussed. Lunar outpost supportability capability needs are summarized and a supportability technology development strategy is established. The resulting Lunar Surface Systems Supportability Strategy defines general criteria that will be used to select technologies that will enable future flight crews to act effectively to respond to problems and exploit opportunities in a environment of extreme resource scarcity and isolation. This strategy also introduces the concept of exploiting flight hardware as a supportability resource. The technology roadmap involves development of three mutually supporting technology categories, Diagnostics Test & Verification, Maintenance & Repair, and Scavenging & Recycling. The technology roadmap establishes two distinct technology types, "Embedded" and "Process" technologies, with different implementation and thus different criteria and development approaches. The supportability technology roadmap addresses the technology readiness level, and estimated development schedule for technology groups that includes down-selection decision gates that correlate with the lunar program milestones. The resulting supportability technology roadmap is intended to develop a set of technologies with widest possible capability and utility with a minimum impact on crew time and training and remain within the time and cost constraints of the Constellation program

A Lunar Surface System Supportability Technology Development Roadmap

NASA Technical Reports Server (NTRS)

Oeftering, Richard C.; Struk, Peter M.; Taleghani, barmac K.

2011-01-01

This paper discusses the establishment of a Supportability Technology Development Roadmap as a guide for developing capabilities intended to allow NASA s Constellation program to enable a supportable, sustainable and affordable exploration of the Moon and Mars. Presented is a discussion of supportability, in terms of space facility maintenance, repair and related logistics and a comparison of how lunar outpost supportability differs from the International Space Station. Supportability lessons learned from NASA and Department of Defense experience and their impact on a future lunar outpost is discussed. A supportability concept for future missions to the Moon and Mars that involves a transition from a highly logistics dependent to a logistically independent operation is discussed. Lunar outpost supportability capability needs are summarized and a supportability technology development strategy is established. The resulting Lunar Surface Systems Supportability Strategy defines general criteria that will be used to select technologies that will enable future flight crews to act effectively to respond to problems and exploit opportunities in an environment of extreme resource scarcity and isolation. This strategy also introduces the concept of exploiting flight hardware as a supportability resource. The technology roadmap involves development of three mutually supporting technology categories, Diagnostics Test and Verification, Maintenance and Repair, and Scavenging and Recycling. The technology roadmap establishes two distinct technology types, "Embedded" and "Process" technologies, with different implementation and thus different criteria and development approaches. The supportability technology roadmap addresses the technology readiness level, and estimated development schedule for technology groups that includes down-selection decision gates that correlate with the lunar program milestones. The resulting supportability technology roadmap is intended to develop a set of technologies with widest possible capability and utility with a minimum impact on crew time and training and remain within the time and cost constraints of the Constellation program.

Evaluating the Impact of a HIV Low-Risk Express Care Task-Shifting Program: A Case Study of the Targeted Learning Roadmap

PubMed Central

Tran, Linh; Yiannoutsos, Constantin T.; Musick, Beverly S.; Wools-Kaloustian, Kara K.; Siika, Abraham; Kimaiyo, Sylvester; van der Laan, Mark J.; Petersen, Maya

2017-01-01

In conducting studies on an exposure of interest, a systematic roadmap should be applied for translating causal questions into statistical analyses and interpreting the results. In this paper we describe an application of one such roadmap applied to estimating the joint effect of both time to availability of a nurse-based triage system (low risk express care (LREC)) and individual enrollment in the program among HIV patients in East Africa. Our study population is comprised of 16,513 subjects found eligible for this task-shifting program within 15 clinics in Kenya between 2006 and 2009, with each clinic starting the LREC program between 2007 and 2008. After discretizing follow-up into 90-day time intervals, we targeted the population mean counterfactual outcome (i. e. counterfactual probability of either dying or being lost to follow up) at up to 450 days after initial LREC eligibility under three fixed treatment interventions. These were (i) under no program availability during the entire follow-up, (ii) under immediate program availability at initial eligibility, but non-enrollment during the entire follow-up, and (iii) under immediate program availability and enrollment at initial eligibility. We further estimated the controlled direct effect of immediate program availability compared to no program availability, under a hypothetical intervention to prevent individual enrollment in the program. Targeted minimum loss-based estimation was used to estimate the mean outcome, while Super Learning was implemented to estimate the required nuisance parameters. Analyses were conducted with the ltmle R package; analysis code is available at an online repository as an R package. Results showed that at 450 days, the probability of in-care survival for subjects with immediate availability and enrollment was 0.93 (95% CI: 0.91, 0.95) and 0.87 (95% CI: 0.86, 0.87) for subjects with immediate availability never enrolling. For subjects without LREC availability, it was 0.91 (95% CI: 0.90, 0.92). Immediate program availability without individual enrollment, compared to no program availability, was estimated to slightly albeit significantly decrease survival by 4% (95% CI 0.03,0.06, p<0.01). Immediately availability and enrollment resulted in a 7 % higher in-care survival compared to immediate availability with non-enrollment after 450 days (95% CI−0.08,−0.05, p<0.01). The results are consistent with a fairly small impact of both availability and enrollment in the LREC program on incare survival. PMID:28736692

Synthesis-Spectroscopy Roadmap Problems: Discovering Organic Chemistry

ERIC Educational Resources Information Center

Kurth, Laurie L.; Kurth, Mark J.

2014-01-01

Organic chemistry problems that interrelate and integrate synthesis with spectroscopy are presented. These synthesis-spectroscopy roadmap (SSR) problems uniquely engage second-year undergraduate organic chemistry students in the personal discovery of organic chemistry. SSR problems counter the memorize-or-bust strategy that many students tend to…

2016-2017 Status Assessment and Update on the Wind Vision Roadmap: Findings from Topical Working Sessions, April 2016 - March 2017

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lantz, Eric J.; Mone, Christopher D.; DeMeo, Edgar

IIn March 2015, the U.S. Department of Energy (DOE) released Wind Vision: A New Era for Wind Power in the United States (DOE 2015), which explores a scenario in which wind provides 10 percent of U.S. electricity in 2020, 20 percent in 2030, and 35 percent in 2050. The Wind Vision report also includes a roadmap of recommended actions aimed at pursuit of the vision and its underlying wind-deployment scenario. The roadmap was compiled by the Wind Vision project team, which included representatives from the industrial, electric-power, government-laboratory, academic, environmental-stewardship, regulatory, and permitting stakeholder groups. The roadmap describes high-level activitiesmore » suitable for all sectors with a stake in wind power and energy development. It is intended to be a 'living document,' and DOE expects to engage the wind community from time to time to track progress.« less

Office of Biological and Physical Research: Overview Transitioning to the Vision for Space Exploration

NASA Technical Reports Server (NTRS)

Crouch, Roger

2004-01-01

Viewgraphs on NASA's transition to its vision for space exploration is presented. The topics include: 1) Strategic Directives Guiding the Human Support Technology Program; 2) Progressive Capabilities; 3) A Journey to Inspire, Innovate, and Discover; 4) Risk Mitigation Status Technology Readiness Level (TRL) and Countermeasures Readiness Level (CRL); 5) Biological And Physical Research Enterprise Aligning With The Vision For U.S. Space Exploration; 6) Critical Path Roadmap Reference Missions; 7) Rating Risks; 8) Current Critical Path Roadmap (Draft) Rating Risks: Human Health; 9) Current Critical Path Roadmap (Draft) Rating Risks: System Performance/Efficiency; 10) Biological And Physical Research Enterprise Efforts to Align With Vision For U.S. Space Exploration; 11) Aligning with the Vision: Exploration Research Areas of Emphasis; 12) Code U Efforts To Align With The Vision For U.S. Space Exploration; 13) Types of Critical Path Roadmap Risks; and 14) ISS Human Support Systems Research, Development, and Demonstration. A summary discussing the vision for U.S. space exploration is also provided.

Risk Interfaces to Support Integrated Systems Analysis and Development

NASA Technical Reports Server (NTRS)

Mindock, Jennifer; Lumpkins, Sarah; Shelhamer, Mark; Anton, Wilma; Havenhill, Maria

2016-01-01

Objectives for systems analysis capability: Develop integrated understanding of how a complex human physiological-socio-technical mission system behaves in spaceflight. Why? Support development of integrated solutions that prevent unwanted outcomes (Implementable approaches to minimize mission resources(mass, power, crew time, etc.)); Support development of tools for autonomy (need for exploration) (Assess and maintain resilience -individuals, teams, integrated system). Output of this exercise: -Representation of interfaces based on Human System Risk Board (HSRB) Risk Summary information and simple status based on Human Research Roadmap; Consolidated HSRB information applied to support communication; Point-of-Departure for HRP Element planning; Ability to track and communicate status of collaborations. 4

76 FR 11308 - Aviation Noise Impacts Roadmap Annual Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-01

... impacts. The purpose of the meeting is to update and advance our collective scientific knowledge of the... Aviation Administration (FAA), National Aeronautics and Space Administration (NASA), Department of Defense... knowledge gaps and future research activities. The intent of the Roadmap is to define systematic, focused...

The Risk Assessment in the 21st Century (RISK21): Roadmap and Matrix

EPA Science Inventory

The RISK21 integrated evaluation strategy is a problem formulation-based exposure-driven risk assessment roadmap that takes advantage of existing information to graphically represent the intersection of exposure and toxicity data on a highly visual matrix. This paper describes i...

Materials Technical Team Roadmap

DOE Office of Scientific and Technical Information (OSTI.GOV)

none,

2013-08-01

Roadmap identifying the efforts of the Materials Technical Team (MTT) to focus primarily on reducing the mass of structural systems such as the body and chassis in light-duty vehicles (including passenger cars and light trucks) which enables improved vehicle efficiency regardless of the vehicle size or propulsion system employed.

NASA's Deep Space Telecommunications Roadmap

NASA Technical Reports Server (NTRS)

Edwards, C., Jr.; Stelzried, C.; Deutsch, L.; Swanson, L.

1998-01-01

This paper will present this roadmap, describe how it will support an increasing mission set while also providing significantly increased science data return, summarize the current state of key Ka-band and optical communications technologies, and identify critical path items in terms of technology developments, demonstrations, and mission users.

Path to a Research Plan

NASA Technical Reports Server (NTRS)

Chiaramonte, Fran

2003-01-01

This viewgraph presentation discusses the status and goals for the NASA OBPR Physical Science Research Program. The following text was used to summarize the presentation. The OBPR Physical Sciences Research program has been comprehensively reviewed and endorsed by National Research Council. The value and need for the research have been re-affirmed. The research program has been prioritized and resource re-allocations have been carried out through an OBPR-wide process. An increasing emphasis on strategic, mission-oriented research is planned. The program will strive to maintain a balance between strategic and fundamental research. A feasible ISS flight research program fitting within the budgetary and ISS resource envelopes has been formulated for the near term (2003-2007). The current ISS research program will be significantly strengthened starting 2005 by using discipline dedicated research facility racks. A research re-planning effort has been initiated and will include active participation from the research community in the next few months. The research re-planning effort will poise PSR to increase ISS research utilization for a potential enhancement beyond ISS IP Core Complete. The Physical Sciences research program readily integrates the cross-disciplinary requirements of the NASA and OBPR strategic objectives. Each fundamental research thrust will develop a roadmap through technical workshops and Discipline Working Groups (DWGs). Most fundamental research thrusts will involve cross-disciplinary efforts. A Technology Roadmap will guide the Strategic Research for Exploration thrust. The Research Plan will integrate and coordinate fundamental Research Thrusts Roadmaps with the Technology Roadmap. The Technology Roadmap will be developed in coordination with other OBPR programs as well as other Enterprise (R,S,M,N). International Partners will contribute to the roadmaps and through research coordination. The research plan will be vetted with the discipline working groups, the BPRAC subcommittees, and with the BPRAC. Recommendations from NRC past and current committees will be implemented whenever appropriate.Proposed theme element content will be "missionized" around planned content and potential new projects (facilities, modules, initiatives) on approximately a five-year horizon, with the approval of PSRD management. Center/science working group teams will develop descriptions of "mission" objectives, value, and requirements. Purpose is to create a competitive environment for concept development and to stimulate community ownership/advocacy. Proposed theme elements reviewed and approved by PSRD management. Strawman roadmaps for themes developed. Program budget and technology requirements verified. Theme elements are prioritized with the input of advisory groups. Integration into program themes (questions) and required technology investments are defined by science and technology roadmaps. Review and assessment by OBPR management.

A roadmap to the brittle bones of cystic fibrosis.

PubMed

Gore, Ashwini P; Kwon, Soon Ho; Stenbit, Antine E

2010-12-16

Cystic fibrosis (CF) is an autosomal recessive disorder which despite advances in medical care continues to be a life-limiting and often fatal disease. With increase in life expectancy of the CF population, bone disease has emerged as a common complication. Unlike the osteoporosis seen in postmenopausal population, bone disease in CF begins at a young age and is associated with significant morbidity due to fractures, kyphosis, increased pain, and decreased lung function. The maintenance of bone health is essential for the CF population during their lives to prevent pain and fractures but also as they approach lung transplantation since severe bone disease can lead to exclusion from lung transplantation. Early recognition, prevention, and treatment are key to maintaining optimal bone health in CF patients and often require a multidisciplinary approach. This article will review the pathophysiology, current clinical practice guidelines, and potential future therapies for treating CF-related bone disease.

Sensors for process control Focus Team report

NASA Astrophysics Data System (ADS)

At the Semiconductor Technology Workshop, held in November 1992, the Semiconductor Industry Association (SIA) convened 179 semiconductor technology experts to assess the 15-year outlook for the semiconductor manufacturing industry. The output of the Workshop, a document entitled 'Semiconductor Technology: Workshop Working Group Reports,' contained an overall roadmap for the technology characteristics envisioned in integrated circuits (IC's) for the period 1992-2007. In addition, the document contained individual roadmaps for numerous key areas in IC manufacturing, such as film deposition, thermal processing, manufacturing systems, exposure technology, etc. The SIA Report did not contain a separate roadmap for contamination free manufacturing (CFM). A key component of CFM for the next 15 years is the use of sensors for (1) defect reduction, (2) improved product quality, (3) improved yield, (4) improved tool utilization through contamination reduction, and (5) real time process control in semiconductor fabrication. The objective of this Focus Team is to generate a Sensors for Process Control Roadmap. Implicit in this objective is the identification of gaps in current sensor technology so that research and development activity in the sensor industry can be stimulated to develop sensor systems capable of meeting the projected roadmap needs. Sensor performance features of interest include detection limit, specificity, sensitivity, ease of installation and maintenance, range, response time, accuracy, precision, ease and frequency of calibration, degree of automation, and adaptability to in-line process control applications.

Roadmap for In-Space Propulsion Technology

NASA Technical Reports Server (NTRS)

Meyer, Michael; Johnson, Les; Palaszewski, Bryan; Coote, David; Goebel, Dan; White, Harold

2012-01-01

NASA has created a roadmap for the development of advanced in-space propulsion technologies for the NASA Office of the Chief Technologist (OCT). This roadmap was drafted by a team of subject matter experts from within the Agency and then independently evaluated, integrated and prioritized by a National Research Council (NRC) panel. The roadmap describes a portfolio of in-space propulsion technologies that could meet future space science and exploration needs, and shows their traceability to potential future missions. Mission applications range from small satellites and robotic deep space exploration to space stations and human missions to Mars. Development of technologies within the area of in-space propulsion will result in technical solutions with improvements in thrust, specific impulse (Isp), power, specific mass (or specific power), volume, system mass, system complexity, operational complexity, commonality with other spacecraft systems, manufacturability, durability, and of course, cost. These types of improvements will yield decreased transit times, increased payload mass, safer spacecraft, and decreased costs. In some instances, development of technologies within this area will result in mission-enabling breakthroughs that will revolutionize space exploration. There is no single propulsion technology that will benefit all missions or mission types. The requirements for in-space propulsion vary widely according to their intended application. This paper provides an updated summary of the In-Space Propulsion Systems technology area roadmap incorporating the recommendations of the NRC.

Extremely Large Telescope Project Selected in ESFRI Roadmap

NASA Astrophysics Data System (ADS)

2006-10-01

In its first Roadmap, the European Strategy Forum on Research Infrastructures (ESFRI) choose the European Extremely Large Telescope (ELT), for which ESO is presently developing a Reference Design, as one of the large scale projects to be conducted in astronomy, and the only one in optical astronomy. The aim of the ELT project is to build before the end of the next decade an optical/near-infrared telescope with a diameter in the 30-60m range. ESO PR Photo 40/06 The ESFRI Roadmap states: "Extremely Large Telescopes are seen world-wide as one of the highest priorities in ground-based astronomy. They will vastly advance astrophysical knowledge allowing detailed studies of inter alia planets around other stars, the first objects in the Universe, super-massive Black Holes, and the nature and distribution of the Dark Matter and Dark Energy which dominate the Universe. The European Extremely Large Telescope project will maintain and reinforce Europe's position at the forefront of astrophysical research." Said Catherine Cesarsky, Director General of ESO: "In 2004, the ESO Council mandated ESO to play a leading role in the development of an ELT for Europe's astronomers. To that end, ESO has undertaken conceptual studies for ELTs and is currently also leading a consortium of European institutes engaged in studying enabling technologies for such a telescope. The inclusion of the ELT in the ESFRI roadmap, together with the comprehensive preparatory work already done, paves the way for the next phase of this exciting project, the design phase." ESO is currently working, in close collaboration with the European astronomical community and the industry, on a baseline design for an Extremely Large Telescope. The plan is a telescope with a primary mirror between 30 and 60 metres in diameter and a financial envelope of about 750 m Euros. It aims at more than a factor ten improvement in overall performance compared to the current leader in ground based astronomy: the ESO Very Large Telescope at the Paranal Observatory. The draft Baseline Reference Design will be presented to the wider scientific community on 29 - 30 November 2006 at a dedicated ELT Workshop Meeting in Marseille (France) and will be further reiterated. The design is then to be presented to the ESO Council at the end of 2006. The goal is to start the detailed E-ELT design work by the first half of 2007. Launched in April 2002, the European Strategy Forum on Research Infrastructures was set-up following a recommendation of the European Union Council, with the role to support a coherent approach to policy-making on research infrastructures in Europe, and to act as an incubator for international negotiations about concrete initiatives. In particular, ESFRI has prepared a European Roadmap identifying new Research Infrastructure of pan-European interest corresponding to the long term needs of the European research communities, covering all scientific areas, regardless of possible location and likely to be realised in the next 10 to 20 years. The Roadmap was presented on 19 October. It is the result of an intensive two-year consultation and peer review process involving over 1000 high level European and international experts. The Roadmap identifies 35 large scale infrastructure projects, at various stages of development, in seven key research areas including Environmental Sciences; Energy; Materials Sciences; Astrophysics, Astronomy, Particle and Nuclear Physics; Biomedical and Life Sciences; Social Sciences and the Humanities; Computation and data Treatment.

A Novel Health Information Technology Communication System to Increase Caregiver Activation in the Context of Hospital-Based Pediatric Hematopoietic Cell Transplantation: A Pilot Study.

PubMed

Maher, Molly; Hanauer, David A; Kaziunas, Elizabeth; Ackerman, Mark S; Derry, Holly; Forringer, Rachel; Miller, Kristen; O'Reilly, Dennis; An, Lawrence; Tewari, Muneesh; Choi, Sung Won

2015-10-27

Pediatric hematopoietic cell transplantation (HCT), commonly referred to as blood and marrow transplantation (BMT), is an intense treatment modality that requires the involvement of engaged caregivers during the patient's (child's) prolonged hospitalization. The ubiquity of electronic health records (EHRs) and a trend toward patient-centered care could allow a novel health information technology (IT) system to increase parental engagement. The paucity of research on acute care, hospital-based (inpatient) health IT applications for patients or caregivers provides an opportunity for testing the feasibility of such applications. The pediatric BMT population represents an ideal patient group to conduct an evaluation due to the lengthy inpatient stays and a heightened need for patient activation. The primary objective of this study is to assess the feasibility of implementing the BMT Roadmap in caregivers as an intervention during their child's inpatient hospitalization. The BMT Roadmap is an inpatient portal prototype optimized for tablet with a user-centered design. It integrates patient-specific laboratory and medication data from the EHR in real-time and provides support in terms of discharge goals, home care education, and other components. Feasibility will be proven if (1) the BMT Roadmap functions and can be managed by the study team without unexpected effort, (2) the system is accessed by users at a defined minimum threshold, and (3) the qualitative and quantitative research conducted provides quality data that address the perceived usefulness of the BMT Roadmap and could inform a study in a larger sample size. This will be a single-arm, nonrandomized feasibility study. We aim to enroll 10 adult caregivers (age ≥ 18 years) of pediatric patients (aged 0-25 years) undergoing autologous (self-donor) or allogeneic (alternative donor) BMT. Assenting minors (aged 10-18) will also be invited to participate. Recruitment of study participants will take place in the outpatient pediatric BMT clinic. After signing an informed consent, the research study team will provide participants with the BMT Roadmap, available on an Apple iPad, which will used throughout the inpatient hospitalization. To measure the study outcomes, approximately 6-8 semistructured qualitative interviews will be conducted periodically from pre-BMT to 100 days post-BMT and an additional 15-20 semistructured interviews will be conducted among BMT health care providers to assess perceived usefulness and usability of the system, as well as any associated workflow impacts. Quantitative survey instruments will only be administered to adult participants (age ≥ 18 years). Recruitment will begin in September 2015, and preliminary findings are expected in 2016. This protocol offers a framework for the design and analysis of a personalized health IT system that has the potential to increase patient and caregiver engagement in acute care, hospital-based contexts.

Space Assembly of Large Structural System Architectures (SALSSA)

NASA Technical Reports Server (NTRS)

Dorsey, John T.; Watson, Judith J.

2016-01-01

Developing a robust capability for Space Assembly of Large Spacecraft Structural System Architectures (SALSSA) has the potential to drastically increase the capabilities and performance of future space missions and spacecraft while significantly reducing their cost. Currently, NASA architecture studies and space science decadal surveys identify new missions that would benefit from SALSSA capabilities, and the technologies that support SALSSA are interspersed throughout the fourteen NASA Technology Roadmaps. However, a major impediment to the strategic development of cross-cutting SALSSA technologies is the lack of an integrated and comprehensive compilation of the necessary information. This paper summarizes the results of a small study that used an integrated approach to formulate a SALSSA roadmap and associated plan for developing key SALSSA technologies.

Advanced Telescopes and Observatories Capability Roadmap Presentation to the NRC

NASA Technical Reports Server (NTRS)

2005-01-01

This viewgraph presentation provides an overview of the NASA Advanced Planning and Integration Office (APIO) roadmap for developing technological capabilities for telescopes and observatories in the following areas: Optics; Wavefront Sensing and Control and Interferometry; Distributed and Advanced Spacecraft; Large Precision Structures; Cryogenic and Thermal Control Systems; Infrastructure.

Roadmap for Navy Family Research.

DTIC Science & Technology

1980-08-01

of methodological limitations, including: small, often non -representative or narrowly defined samples; inadequate statistical controls, inadequate...1-1 1.2 Overview of the Research Roadmap ..................... 1-2 2. Methodology ...the Office of Naval Research by the Westinghouse Public Applied Systems Division, and is designed to provide the Navy with a systematic framework for

Clean Cities Roadmap : A resource for developing, implementing, and sustaining your clean cities program

DOT National Transportation Integrated Search

2001-08-01

This roadmap explains how your community can join forces with the nationwide network of Clean Cities to increase the use of alternative fuels and alternative fuel vehicles (AFVs). You will learn how the U.S. Department of Energy (DOE) can help your c...

Leveraging Our Expertise To Inform International RE Roadmaps | Energy

Science.gov Websites

energy targets to support Mexico's renewable energy goal. NREL and its Mexico partners developed the institutions need to take to determine how the electricity infrastructure and systems must change to accommodate high levels of renewables. The roadmap focuses on analysis methodologies-including grid expansion

Human Health and Support Systems Capability Roadmap Progress Review

NASA Technical Reports Server (NTRS)

Grounds, Dennis; Boehm, Al

2005-01-01

The Human Health and Support Systems Capability Roadmap focuses on research and technology development and demonstration required to ensure the health, habitation, safety, and effectiveness of crews in and beyond low Earth orbit. It contains three distinct sub-capabilities: Human Health and Performance. Life Support and Habitats. Extra-Vehicular Activity.

Roadmapping towards Sustainability Proficiency in Engineering Education

ERIC Educational Resources Information Center

Rodriguez-Andara, Alejandro; Río-Belver, Rosa María; Rodríguez-Salvador, Marisela; Lezama-Nicolás, René

2018-01-01

Purpose: The purpose of this paper is to deliver a roadmap that displays pathways to develop sustainability skills in the engineering curricula. Design/methodology/approach: The selected approach to enrich engineering students with sustainability skills was active learning methodologies. First, a survey was carried out on a sample of 189 students…

Six Tips for Successful IEP Meetings

ERIC Educational Resources Information Center

Diliberto, Jennifer A.; Brewer, Denise

2012-01-01

Individuals with Disabilities Education Improvement Act (IDEIA, 2004) mandates that each student with a disability has an individualized education program (IEP). The IEP serves as the curriculum roadmap for special education services. In order to generate a clear roadmap, full team communication is necessary. The purpose of this paper is to…

An Imaging Roadmap for Biology Education: From Nanoparticles to Whole Organisms

ERIC Educational Resources Information Center

Kelley, Daniel J.; Davidson, Richard J.; Nelson, David L.

2008-01-01

Imaging techniques provide ways of knowing structure and function in biology at different scales. The multidisciplinary nature and rapid advancement of imaging sciences requires imaging education to begin early in the biology curriculum. Guided by the National Institutes of Health (NIH) Roadmap initiatives, we incorporated a nanoimaging, molecular…

Science Instruments and Sensors Capability Roadmap: NRC Dialogue

NASA Technical Reports Server (NTRS)

Barney, Rich; Zuber, Maria

2005-01-01

The Science Instruments and Sensors roadmaps include capabilities associated with the collection, detection, conversion, and processing of scientific data required to answer compelling science questions driven by the Vision for Space Exploration and The New Age of Exploration (NASA's Direction for 2005 & Beyond). Viewgraphs on these instruments and sensors are presented.

Sustainable Electronic Roadmap and Forum Summary; Sustainable Electronics Forum, October 15-18, 2012, Racine, WI

EPA Science Inventory

The Roadmap presents critical issues and research questions for each theme. For Theme 1, the issues for limiting the harm from materials and process in electronics industry include identifying the chemicals in products, production process, in the extraction of virgin materials, i...

Review of the Semiconductor Industry and Technology Roadmap.

ERIC Educational Resources Information Center

Kumar, Sameer; Krenner, Nicole

2002-01-01

Points out that the semiconductor industry is extremely competitive and requires ongoing technological advances to improve performance while reducing costs to remain competitive and how essential it is to gain an understanding of important facets of the industry. Provides an overview of the initial and current semiconductor technology roadmap that…

The 2017 Magnetism Roadmap

NASA Astrophysics Data System (ADS)

Sander, D.; Valenzuela, S. O.; Makarov, D.; Marrows, C. H.; Fullerton, E. E.; Fischer, P.; McCord, J.; Vavassori, P.; Mangin, S.; Pirro, P.; Hillebrands, B.; Kent, A. D.; Jungwirth, T.; Gutfleisch, O.; Kim, C. G.; Berger, A.

2017-09-01

Building upon the success and relevance of the 2014 Magnetism Roadmap, this 2017 Magnetism Roadmap edition follows a similar general layout, even if its focus is naturally shifted, and a different group of experts and, thus, viewpoints are being collected and presented. More importantly, key developments have changed the research landscape in very relevant ways, so that a novel view onto some of the most crucial developments is warranted, and thus, this 2017 Magnetism Roadmap article is a timely endeavour. The change in landscape is hereby not exclusively scientific, but also reflects the magnetism related industrial application portfolio. Specifically, Hard Disk Drive technology, which still dominates digital storage and will continue to do so for many years, if not decades, has now limited its footprint in the scientific and research community, whereas significantly growing interest in magnetism and magnetic materials in relation to energy applications is noticeable, and other technological fields are emerging as well. Also, more and more work is occurring in which complex topologies of magnetically ordered states are being explored, hereby aiming at a technological utilization of the very theoretical concepts that were recognised by the 2016 Nobel Prize in Physics. Given this somewhat shifted scenario, it seemed appropriate to select topics for this Roadmap article that represent the three core pillars of magnetism, namely magnetic materials, magnetic phenomena and associated characterization techniques, as well as applications of magnetism. While many of the contributions in this Roadmap have clearly overlapping relevance in all three fields, their relative focus is mostly associated to one of the three pillars. In this way, the interconnecting roles of having suitable magnetic materials, understanding (and being able to characterize) the underlying physics of their behaviour and utilizing them for applications and devices is well illustrated, thus giving an accurate snapshot of the world of magnetism in 2017. The article consists of 14 sections, each written by an expert in the field and addressing a specific subject on two pages. Evidently, the depth at which each contribution can describe the subject matter is limited and a full review of their statuses, advances, challenges and perspectives cannot be fully accomplished. Also, magnetism, as a vibrant research field, is too diverse, so that a number of areas will not be adequately represented here, leaving space for further Roadmap editions in the future. However, this 2017 Magnetism Roadmap article can provide a frame that will enable the reader to judge where each subject and magnetism research field stands overall today and which directions it might take in the foreseeable future. The first material focused pillar of the 2017 Magnetism Roadmap contains five articles, which address the questions of atomic scale confinement, 2D, curved and topological magnetic materials, as well as materials exhibiting unconventional magnetic phase transitions. The second pillar also has five contributions, which are devoted to advances in magnetic characterization, magneto-optics and magneto-plasmonics, ultrafast magnetization dynamics and magnonic transport. The final and application focused pillar has four contributions, which present non-volatile memory technology, antiferromagnetic spintronics, as well as magnet technology for energy and bio-related applications. As a whole, the 2017 Magnetism Roadmap article, just as with its 2014 predecessor, is intended to act as a reference point and guideline for emerging research directions in modern magnetism.

CNES Strategic Plan for Space Traffic Control

NASA Astrophysics Data System (ADS)

Alby, Fernand

2013-09-01

The increasing orbital debris population represents a growing risk to operational satellites on-orbit and also to populations and properties on-ground. Today available space surveillance data allow a better implementation of protection activities which are now part of operational services. The overall frame of these activities at CNES is given by a strategic plan defining the long term views and the corresponding activities to be carried out during the next years. This plan, established in close cooperation with French Defence organizations, includes, among others, two operational space traffic control activities: prevention of on-orbit collisions and atmospheric re-entries predictions.This paper presents first the national organization relative to these activities together with the internal CNES process starting from a high level roadmap, up to a detailed action plan. This plan contains operational activities and supporting studies and models development.The content of this plan is given with a focus on operational activities dealing with space traffic control.

JAXA's Space Exploration Scenario

NASA Astrophysics Data System (ADS)

Sato, N. S.

2018-04-01

Japan Aerospace Exploration Agency (JAXA) has been studying space exploration scenario, including human exploration for Japan since 2015, which encompasses goals, knowledge gap assessment, and architecture. assessment, and technology roadmap.

VERAM, for a sustainable and competitive future for EU Raw Materials

NASA Astrophysics Data System (ADS)

Mobili, A.; Tittarelli, F.; Revel, G. M.; Wall, P.

2018-03-01

The project, VERAM “Vision and Roadmap for European Raw Materials”, aims to deliver a mapping of on-going initiatives on non-food, non-energy raw materials (including metals, industrial minerals, aggregates and wood) at European, Member State, and regional levels both from the Research and Innovation (R&I), industry, and policy perspectives. Moreover, based on a comprehensive gap analysis, VERAM will propose a common long term 2050 Vision and Roadmap in coordination and cooperation with all stakeholders across the value chain. For the first time, two European Technology Platforms (ETPs) together with their corresponding European Research Area Networks (ERA-NETs) are joining forces to develop a common roadmap.

Fundamental Physics Changes in Response to Evolving NASA Needs

NASA Technical Reports Server (NTRS)

Israelsson, Ulf

2003-01-01

To continue growing as a discipline, we need to establish a new vision of where we are going that is consistent with today s physics, NASA s strategic plan, and the new OBPR direction. 1998 Roadmap focused exclusively on Physics, and did not worry about boundaries between OBPR and OSS. Updated Roadmap: Must incorporate some strategic research activities to be fully responsive to the current OBPR direction. Must capture the imagination of OBPR leadership, OMB, and Congress. Must delineate OBPR from the "beyond Einstein" program in OSS. Must address relevancy to Society explicitly. Status of the Roadmap development will be discussed after lunch today. Seeking community inputs and endorsement. Draft update targeted for June, final in August.

Clonal analysis of lineage fate in native haematopoiesis.

PubMed

Rodriguez-Fraticelli, Alejo E; Wolock, Samuel L; Weinreb, Caleb S; Panero, Riccardo; Patel, Sachin H; Jankovic, Maja; Sun, Jianlong; Calogero, Raffaele A; Klein, Allon M; Camargo, Fernando D

2018-01-11

Haematopoiesis, the process of mature blood and immune cell production, is functionally organized as a hierarchy, with self-renewing haematopoietic stem cells and multipotent progenitor cells sitting at the very top. Multiple models have been proposed as to what the earliest lineage choices are in these primitive haematopoietic compartments, the cellular intermediates, and the resulting lineage trees that emerge from them. Given that the bulk of studies addressing lineage outcomes have been performed in the context of haematopoietic transplantation, current models of lineage branching are more likely to represent roadmaps of lineage potential than native fate. Here we use transposon tagging to clonally trace the fates of progenitors and stem cells in unperturbed haematopoiesis. Our results describe a distinct clonal roadmap in which the megakaryocyte lineage arises largely independently of other haematopoietic fates. Our data, combined with single-cell RNA sequencing, identify a functional hierarchy of unilineage- and oligolineage-producing clones within the multipotent progenitor population. Finally, our results demonstrate that traditionally defined long-term haematopoietic stem cells are a significant source of megakaryocyte-restricted progenitors, suggesting that the megakaryocyte lineage is the predominant native fate of long-term haematopoietic stem cells. Our study provides evidence for a substantially revised roadmap for unperturbed haematopoiesis, and highlights unique properties of multipotent progenitors and haematopoietic stem cells in situ.

76 FR 67418 - Request for Comments on NIST Special Publication 500-293, US Government Cloud Computing...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-01

...-1659-01] Request for Comments on NIST Special Publication 500-293, US Government Cloud Computing... Publication 500-293, US Government Cloud Computing Technology Roadmap, Release 1.0 (Draft). This document is... (USG) agencies to accelerate their adoption of cloud computing. The roadmap has been developed through...

Space Communications Capability Roadmap Interim Review

NASA Technical Reports Server (NTRS)

Spearing, Robert; Regan, Michael

2005-01-01

Contents include the following: Identify the need for a robust communications and navigation architecture for the success of exploration and science missions. Describe an approach for specifying architecture alternatives and analyzing them. Establish a top level architecture based on a network of networks. Identify key enabling technologies. Synthesize capability, architecture and technology into an initial capability roadmap.

FY2009-2034 Unmanned Systems Integrated Roadmap

DTIC Science & Technology

2009-04-20

FY2009–2034 Unmanned Systems Integrated Roadmap Page i Report Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting burden for the...56 A.1.7 XM-156 Class I ...60 A.1.11 Improved Gnat Extended Range ( I -Gnat-ER) “Warrior Alpha” / Extended Range/Multi- purpose (ER/MP) Block

THE DOE COMPLEX-WIDE VADOSE ZONE SCIENCE AND TECHNOLOGY ROADMAP: CHARACTERIZATION MODELING AND SIMULATION OF SUBSURFACE CONTAMINANT FATE AND TRANSPORT

EPA Science Inventory

The Idaho National Engineering & Environmental Lab (INEEL) was charged by DOE EM to develop a complex-wide science and technology roadmap for the characterization, modeling and simulation of the fate and transport of contamination in the vadose zone. Various types of hazardous, r...

Virtual Learning and Instructional Tools: Perfecting the Weekly Roadmap

ERIC Educational Resources Information Center

Cicco, Gina

2015-01-01

This article will provide details on the importance of providing structure within an online graduate counseling course in the form of a weekly roadmap tool. There are various instructional tools that may be useful in providing students with differing levels of structure, to meet their learning style preferences for structural stimuli (Cicco,…

Cellular Therapies Clinical Research Roadmap: Lessons learned on how to move a cellular therapy into a clinical trial

PubMed Central

Ouseph, Stacy; Tappitake, Darah; Armant, Myriam; Wesselschmidt, Robin; Derecho, Ivy; Draxler, Rebecca; Wood, Deborah; Centanni, John M.

2014-01-01

A clinical research roadmap has been developed as a resource for researchers to identify critical areas and potential pitfalls when transitioning a cellular therapy product from the research laboratory, via and Investigational New Drug (IND) application, into early phase clinical trials. The roadmap describes four key areas; basic and preclinical research, resource development, translational research and good manufacturing practice (GMP), and IND assembly and submission. Basic and preclinical research identifies a new therapeutic concept and demonstrates its potential value using a model of the relevant disease. During resource development the appropriate specialists and the required expertise to bring this product into the clinic are identified (e.g., researchers, regulatory specialists, GMP manufacturing staff, clinicians, and clinical trials staff, etc.). Additionally, the funds required to achieve this goal (or a plan to procure them) are identified. In the next phase the plan to translate the research product into a clinical grade therapeutic is developed. Finally regulatory approval to start the trial must be obtained. In the United States this is done by filing an IND application with the Food and Drug Administration. The NHLBI-funded Production Assistance for Cellular Therapies (PACT) program has facilitated the transition of a variety of cellular therapy products from the laboratory into Phase1/2 trials. The five PACT facilities have assisted investigators by performing translational studies and GMP manufacturing to ensure that cellular products met release specifications and were manufactured safely, reproducibly, and at the appropriate scale. The roadmap resulting from this experience is the focus of this article. PMID:25484311

The NASA Astrobiology Roadmap

NASA Technical Reports Server (NTRS)

Des Marais, David J.; Allamandola, Louis J.; Benner, Steven A.; Boss, Alan P.; Deamer, David; Falkowski, Paul G.; Farmer, Jack D.; Hedges, S. Blair; Jakosky, Bruce M.; Knoll, Andrew H.;

The NASA Astrobiology Roadmap.

PubMed

Des Marais, David J; Allamandola, Louis J; Benner, Steven A; Boss, Alan P; Deamer, David; Falkowski, Paul G; Farmer, Jack D; Hedges, S Blair; Jakosky, Bruce M; Knoll, Andrew H; Liskowsky, David R; Meadows, Victoria S; Meyer, Michael A; Pilcher, Carl B; Nealson, Kenneth H; Spormann, Alfred M; Trent, Jonathan D; Turner, William W; Woolf, Neville J; Yorke, Harold W

2003-01-01

The NASA Astrobiology Roadmap provides guidance for research and technology development across the NASA enterprises that encompass the space, Earth, and biological sciences. The ongoing development of astrobiology roadmaps embodies the contributions of diverse scientists and technologists from government, universities, and private institutions. The Roadmap addresses three basic questions: How does life begin and evolve, does life exist elsewhere in the universe, and what is the future of life on Earth and beyond? Seven Science Goals outline the following key domains of investigation: understanding the nature and distribution of habitable environments in the universe, exploring for habitable environments and life in our own solar system, understanding the emergence of life, determining how early life on Earth interacted and evolved with its changing environment, understanding the evolutionary mechanisms and environmental limits of life, determining the principles that will shape life in the future, and recognizing signatures of life on other worlds and on early Earth. For each of these goals, Science Objectives outline more specific high-priority efforts for the next 3-5 years. These 18 objectives are being integrated with NASA strategic planning.

The NASA Astrobiology Roadmap.

PubMed

Des Marais, David J; Nuth, Joseph A; Allamandola, Louis J; Boss, Alan P; Farmer, Jack D; Hoehler, Tori M; Jakosky, Bruce M; Meadows, Victoria S; Pohorille, Andrew; Runnegar, Bruce; Spormann, Alfred M

2008-08-01

The NASA Astrobiology Roadmap provides guidance for research and technology development across the NASA enterprises that encompass the space, Earth, and biological sciences. The ongoing development of astrobiology roadmaps embodies the contributions of diverse scientists and technologists from government, universities, and private institutions. The Roadmap addresses three basic questions: how does life begin and evolve, does life exist elsewhere in the universe, and what is the future of life on Earth and beyond? Seven Science Goals outline the following key domains of investigation: understanding the nature and distribution of habitable environments in the universe, exploring for habitable environments and life in our own Solar System, understanding the emergence of life, determining how early life on Earth interacted and evolved with its changing environment, understanding the evolutionary mechanisms and environmental limits of life, determining the principles that will shape life in the future, and recognizing signatures of life on other worlds and on early Earth. For each of these goals, Science Objectives outline more specific high priority efforts for the next three to five years. These eighteen objectives are being integrated with NASA strategic planning.

Nebulized antibiotics in mechanically ventilated patients: roadmap and challenges.

PubMed

Poulakou, G; Siakallis, G; Tsiodras, S; Arfaras-Melainis, A; Dimopoulos, G

2017-03-01

Nebulized antibiotics use has become common practice in the therapeutics of pneumonia in cystic fibrosis patients. There is an increasing interest in their use for respiratory infections in mechanically ventilated (MV) patients in order to a) overcome pharmacokinetic issues in the lung compartment with traditional systemic antibiotic use and b) prevent the emergence of multi-drug-resistant (MDR) pathogens. Areas covered: The beneficial effects of antibiotic nebulization in MV patients e.g. increasing efficacy, reduced toxicity and prevention of resistance are described. Physicochemical parameters of optimal lung deposition, characteristics of currently available nebulizers, practical aspects of the procedure, including drug preparation and adjustments of ventilator and circuit parameter are presented. Antibiotics used in nebulized route, along with efficacy in various clinical indications and safety issues are reviewed. Expert commentary: The safety of nebulization of antibiotics has been proven in numerous studies; efficacy as adjunctive treatment to intravenous regimens or as monotherapy has been demonstrated in ventilator-associated pneumonia or ventilator-associated tracheobronchitis due to MDR or susceptible pathogens. However, due to the heterogeneity of studies, multiple meta-analyses fail to demonstrate a clear effect. Clarification of indications, standardization of technique and implementation of clinical practice guidelines, based on new large-scale trials will lead to the optimal use of nebulized antibiotics.

Elder mistreatment: priorities for consideration by the white house conference on aging.

PubMed

Pillemer, Karl; Connolly, Marie-Therese; Breckman, Risa; Spreng, Nathan; Lachs, Mark S

2015-04-01

Elder mistreatment is recognized internationally as a prevalent and growing problem, meriting the attention of policymakers, practitioners, and the general public. Studies have demonstrated that elder mistreatment is sufficiently widespread to be a major public health concern and that it leads to a range of negative physical, psychological, and financial outcomes. This article provides an overview of key issues related to the prevention and treatment of elder mistreatment, focusing on initiatives that can be addressed by the White House Conference on Aging. We review research on the extent of mistreatment and its consequences. We then propose 3 challenges in preventing and treating elder mistreatment that relate to improving research knowledge, creating a comprehensive service system, and developing effective policy. Under each challenge, examples are provided of promising initiatives that can be taken to eliminate mistreatment. To inform the recommendations, we employed recent data from the Elder Justice Roadmap Project, in which 750 stakeholders in the field of elder mistreatment were surveyed regarding research and policy priorities. © The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Web-based Academic Roadmaps for Careers in the Geosciences

NASA Astrophysics Data System (ADS)

Murray, D. P.; Veeger, A. I.; Grossman-Garber, D.

2007-12-01

To a greater extent than most science programs, geology is underrepresented in K-12 curricula and the media. Thus potential majors have scant knowledge of academic requirements and career trajectories, and their idea of what geologists do--if they have one at all--is outdated. We have addressed these concerns by developing a dynamic, web-based academic roadmap for current and prospective students, their families, and others who are contemplating careers in the geosciences. The goals of this visually attractive "educational pathway" are to not only improve student recruitment and retention, but to empower student learning by creating better communication and advising tools that can render our undergraduate program transparent for learners and their families. Although we have developed academic roadmaps for four environmental and life science programs at the University of Rhode Island, we focus here on the roadmap for the geosciences, which illustrates educational pathways along the academic and early-career continuum for current and potential (i.e., high school) students who are considering the earth sciences. In essence, the Geosciences Academic Roadmap is a "one-stop'" portal to the discipline. It includes user- friendly information about our curriculum, outcomes (which at URI are tightly linked to performance in courses and the major), extracurricular activities (e.g., field camp, internships), careers, graduate programs, and training. In the presentation of this material extensive use is made of streaming video, interviews with students and earth scientists, and links to other relevant sites. Moreover, through the use of "Hot Topics", particular attention is made to insure that examples of geoscience activities are not only of relevance to today's students, but show geologists using the modern methods of the discipline in exciting ways. Although this is a "work-in-progress", evaluation of the sites, by high school through graduate students, has been strongly positive. Our presentation will include a demonstration of the Academic Roadmap, and a template that can be used by other geoscience departments to easily design websites.

Developmental Process and Early Phases of Implementation for the US Interagency Committee on Human Nutrition Research National Nutrition Research Roadmap 2016-2021.

PubMed

Fleischhacker, Sheila E; Ballard, Rachel M; Starke-Reed, Pamela E; Galuska, Deborah A; Neuhouser, Marian L

2017-10-01

The Interagency Committee on Human Nutrition Research (ICHNR) is charged with improving the planning, coordination, and communication among federal agencies engaged in nutrition research and with facilitating the development and updating of plans for federal research programs to meet current and future domestic and international needs for nutrition. The ICHNR is co-chaired by the USDA Under Secretary for Research, Education, and Economics and Chief Scientist and the US Department of Health and Human Services Assistant Secretary for Health and is made up of >10 departments and agencies. Once the ICHNR was reassembled after a 10-y hiatus, the ICHNR recognized a need for a written roadmap to identify critical human nutrition research gaps and opportunities. This commentary provides an overview of the process the ICHNR undertook to develop a first-of-its-kind National Nutrition Research Roadmap, which was publicly released on 4 March 2016. The primary audience for the Roadmap is federal science agency leaders, along with relevant program and policy staff who rely on federally supported human nutrition research, in addition to the broader scientific community. The Roadmap is framed around the following 3 questions: 1 ) How can we better understand and define eating patterns to improve and sustain health? 2 ) What can be done to help people choose healthy eating patterns? 3 ) How can we develop and engage innovative methods and systems to accelerate discoveries in human nutrition? Within these 3 questions, 11 topical areas were identified on the basis of the following criteria: population impact, feasibility given current technological capacities, and emerging scientific opportunities. This commentary highlights initial federal and some professional research society efforts to address the Roadmap's research and resource priorities. We conclude by noting examples of early collaborations and partnerships to move human nutrition research forward in the 21st century. © 2017 American Society for Nutrition.

Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10.

PubMed

Seegar, Tom C M; Killingsworth, Lauren B; Saha, Nayanendu; Meyer, Peter A; Patra, Dhabaleswar; Zimmerman, Brandon; Janes, Peter W; Rubinstein, Eric; Nikolov, Dimitar B; Skiniotis, Georgios; Kruse, Andrew C; Blacklow, Stephen C

2017-12-14

Cleavage of membrane-anchored proteins by ADAM (a disintegrin and metalloproteinase) endopeptidases plays a key role in a wide variety of biological signal transduction and protein turnover processes. Among ADAM family members, ADAM10 stands out as particularly important because it is both responsible for regulated proteolysis of Notch receptors and catalyzes the non-amyloidogenic α-secretase cleavage of the Alzheimer's precursor protein (APP). We present here the X-ray crystal structure of the ADAM10 ectodomain, which, together with biochemical and cellular studies, reveals how access to the enzyme active site is regulated. The enzyme adopts an unanticipated architecture in which the C-terminal cysteine-rich domain partially occludes the enzyme active site, preventing unfettered substrate access. Binding of a modulatory antibody to the cysteine-rich domain liberates the catalytic domain from autoinhibition, enhancing enzymatic activity toward a peptide substrate. Together, these studies reveal a mechanism for regulation of ADAM activity and offer a roadmap for its modulation. Copyright © 2017 Elsevier Inc. All rights reserved.

Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof-of-concept and roadmap for future studies

PubMed Central

Anttila, Verneri; Hibar, Derrek P; van Hulzen, Kimm J E; Arias-Vasquez, Alejandro; Smoller, Jordan W; Nichols, Thomas E; Neale, Michael C; McIntosh, Andrew M; Lee, Phil; McMahon, Francis J; Meyer-Lindenberg, Andreas; Mattheisen, Manuel; Andreassen, Ole A; Gruber, Oliver; Sachdev, Perminder S; Roiz-Santiañez, Roberto; Saykin, Andrew J; Ehrlich, Stefan; Mather, Karen A; Turner, Jessica A; Schwarz, Emanuel; Thalamuthu, Anbupalam; Shugart, Yin Yao; Ho, Yvonne YW; Martin, Nicholas G; Wright, Margaret J

2016-01-01

Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between schizophrenia cases and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. The current study provides proof-of-concept (albeit based on a limited set of structural brain measures), and defines a roadmap for future studies investigating the genetic covariance between structural/functional brain phenotypes and risk for psychiatric disorders. PMID:26854805

Roadmap to Guide U.S. Photovoltaics Industry in 21st Century

Science.gov Websites

industry wants them to have it. Solar-cell manufacturers and suppliers see photovoltaics (PV) producing at Roadmap to Guide U.S. Photovoltaics Industry in 21st Century Solar energy will provide emergency Douglas Golden, Colo., Jan. 20, 2000 - Americans want clean solar electricity. The U.S. photovoltaics

Going Further: A Roadmap to the Works of the ACCLAIM Research Initiative. Working Paper No. 42

ERIC Educational Resources Information Center

Wilson, Zach; Howley, Craig

2012-01-01

"Going Further" presents a roadmap to the works of the ACCLAIM (Appalachian Collaborative Center for Learning, Assessment, and Instruction in Mathematics) Research Initiative, the research effort of one the Centers for Learning and Teaching (CLTs) created with a grant (2001-2005) from the National Science Foundation. The Center began…

Reducing Energy Burden with Solar: Colorado's Strategy and Roadmap for

Science.gov Websites

-income residents suffer from a high energy burden, which can force these residents to choose between . The report concludes with a roadmap other states might consider when developing their own low-income states might learn from the state's experience when they design their own programs. The report concludes

NASA Technology Area 1: Launch Propulsion Systems

NASA Technical Reports Server (NTRS)

McConnaughey, Paul; Femminineo, Mark; Koelfgen, Syri; Lepsch, Roger; Ryan, Richard M.; Taylor, Steven A.

2011-01-01

This slide presentation reviews the technology advancements plans for the NASA Technology Area 1, Launch Propulsion Systems Technology Area (LPSTA). The draft roadmap reviews various propulsion system technologies that will be developed during the next 25 + years. This roadmap will be reviewed by the National Research Council which will issue a final report, that will include findings and recommendations.

Data Decision-Making and Program-Wide Implementation of the Pyramid Model. Roadmap to Effective Intervention Practices #7

ERIC Educational Resources Information Center

Fox, Lise; Veguilla, Myrna; Perez Binder, Denise

2014-01-01

The Technical Assistance Center on Social Emotional Intervention for Young Children (TACSEI) Roadmap on "Data Decision-Making and Program-Wide Implementation of the Pyramid Model" provides programs with guidance on how to collect and use data to ensure the implementation of the Pyramid Model with fidelity and decision-making that…

U.S. Department of Energy Office of Indian Energy Policy and Programs: Strategic Roadmap 2025

DOE Office of Scientific and Technical Information (OSTI.GOV)

The U.S. Department of Energy Office of Indian Energy Policy and Programs Strategic Roadmap 2025 outlines strategic target areas and tactical actions to ensure the Office remains aligned with its congressional mandates and DOE goals, and that it can be responsive to changing conditions in Indian Country and the nation.

Defining the role of silvicultural research in the Northeastern Forest Experiment Station

Treesearch

Chris Nowak; Susan Stout; John Brissette; Laura Kenefic; Gary Miller; Bill Leak; Dan Yaussy; Tom Schuler; Kurt Gottschalk

1997-01-01

Research planning in the Northeastern Forest Experiment Station has followed a grass roots model for more than two years-ROADMAP, a research and development management plan. The goals for research within ROADMAP include understanding, protecting, managing, and utilizing forest ecosystems. There are nine research themes set to help achieve these goals, each with a set...

The technology roadmap for plant/crop-based renewable resources 2020

DOE Office of Scientific and Technical Information (OSTI.GOV)

McLaren, J.

1999-02-22

The long-term well-being of the nation and maintenance of a sustainable leadership position in agriculture, forestry, and manufacturing, clearly depend on current and near-term support of multidisciplinary research for the development of a reliable renewable resource base. This document sets a roadmap and priorities for that research. America needs leadership that will continue to recognize, support, and move rapidly to meet the need to expand the use of sustainable renewable resources. This roadmap has highlighted potential ways for progress and has identified goals in specific components of the system. Achieving success with these goals will provide the opportunity to hitmore » the vision target of a fivefold increase in renewable resource use by 2020.« less

The Technology Roadmap for Plant/Crop-Based Renewable Resources 2020

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1999-02-01

The long-term well-being of the nation and maintenance of a sustainable leadership position in agriculture, forestry, and manufacturing, clearly depend on current and near-term support of multidisciplinary research for the development of a reliable renewable resource base. This document sets a roadmap and priorities for that research. America needs leadership that will continue to recognize, support, and move rapidly to meet the need to expand the use of sustainable renewable resources. This roadmap has highlighted potential ways for progress and has identified goals in specific components of the system. Achieving success with these goals will provide the opportunity to hitmore » the vision target of a fivefold increase in renewable resource use by 2020.« less

The Peroxide Pathway

NASA Technical Reports Server (NTRS)

McNeal, Curtis I., Jr.; Anderson, William

1999-01-01

NASA's current focus on technology roadmaps as a tool for guiding investment decisions leads naturally to a discussion of NASA's roadmap for peroxide propulsion system development. NASA's new Second Generation Space Transportation System roadmap calls for an integrated Reusable Upper-Stage (RUS) engine technology demonstration in the FY03/FY04 time period. Preceding this integrated demonstration are several years of component developments and subsystem technology demonstrations. NASA and the Air Force took the first steps at developing focused upper stage technologies with the initiation of the Upper Stage Flight Experiment with Orbital Sciences in December 1997. A review of this program's peroxide propulsion development is a useful first step in establishing the peroxide propulsion pathway that could lead to a RUS demonstration in 2004.

A roadmap to effective urban climate change adaptation

NASA Astrophysics Data System (ADS)

Setiadi, R.

2018-03-01

This paper outlines a roadmap to effective urban climate change adaptation built from our practical understanding of the evidence and effects of climate change and the preparation of climate change adaptation strategies and plans. This roadmap aims to drive research in achieving fruitful knowledge and solution-based achievable recommendations in adapting to climate change in urban areas with effective and systematic manner. This paper underscores the importance of the interplay between local government initiatives and a national government for effective adaptation to climate change and takes into account the policy process and politics. This paper argues that effective urban climate change adaptation has a contribution to build urban resilience and helps the achievement of national government goals and targets in climate change adaptation.

Capturing the Sun: A Roadmap for Navigating Data-Access Challenges and Auto-Populating Solar Home Sales Listings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stukel, Laura; Hoen, Ben; Adomatis, Sandra

Capturing the Sun: A Roadmap for Navigating Data-Access Challenges and Auto-Populating Solar Home Sales Listings supports a vision of solar photovoltaic (PV) advocates and real estate advocates evolving together to make information about solar homes more accessible to home buyers and sellers and to simplify the process when these homes are resold. The Roadmap is based on a concept in the real estate industry known as automatic population of fields. Auto-population (also called auto-pop in the industry) is the technology that allows data aggregated by an outside industry to be matched automatically with home sale listings in a multiple listingmore » service (MLS).« less

Global tobacco prevention and control in relation to a cardiovascular health promotion and disease prevention framework: A narrative review.

PubMed

Carroll, Allison J; Labarthe, Darwin R; Huffman, Mark D; Hitsman, Brian

2016-12-01

The purpose of this review is to emphasize the role of tobacco prevention and control in cardiovascular health (CVH) promotion and cardiovascular disease (CVD) prevention, including the importance of these endpoints for measuring the full impact of tobacco-related policies, programs, and practices. In this review, we describe an overview of tobacco control interventions that have led to substantial declines in tobacco use and the relationship between these declines with CVH and CVD. We review interventions that have had success in high-income countries (HICs) as well as those that are gaining traction in low- and middle-income countries (LMICs). We emphasize the challenges to comprehensive tobacco prevention and control strategies faced by LMICs, and highlight the special role of cardiovascular health professionals in achieving CVH promotion and CVD prevention endpoints through tobacco control. Tobacco prevention and control strategies have a strong scientific basis, yet a distinct gap remains between this evidence and implementation of tobacco control policies, particularly in LMICs. Health professionals can contribute to tobacco control efforts, especially through patient-level clinical interventions, when supported by a health care system and government that recognize and support tobacco control as a critical strategy for CVH promotion and CVD prevention. Understanding, supporting, and applying current and evolving policies, programs, and practices in tobacco prevention and control is the province of all health professionals, especially those concerned with CVH promotion and CVD prevention. A new tobacco control roadmap from the World Heart Federation provides a strong impetus to the needed interdisciplinary collaboration. Copyright © 2016 Elsevier Inc. All rights reserved.

Global tobacco prevention and control in relation to a cardiovascular health promotion and disease prevention framework: A narrative review

PubMed Central

Carroll, Allison J.; Labarthe, Darwin R.; Huffman, Mark D.; Hitsman, Brian

2016-01-01

The purpose of this review is to emphasize the role of tobacco prevention and control in cardiovascular health (CVH) promotion and cardiovascular disease (CVD) prevention, including the importance of these endpoints for measuring the full impact of tobacco-related policies, programs, and practices. In this review, we describe an overview of tobacco control interventions that have led to substantial declines in tobacco use and the relationship between these declines with CVH and CVD. We review interventions that have had success in high-income countries (HICs) as well as those that are gaining traction in low- and middle-income countries (LMICs). We emphasize the challenges to comprehensive tobacco prevention and control strategies faced by LMICs, and highlight the special role of cardiovascular health professionals in achieving CVH promotion and CVD prevention endpoints through tobacco control. Tobacco prevention and control strategies have a strong scientific basis, yet a distinct gap remains between this evidence and implementation of tobacco control policies, particularly in LMICs. Health professionals can contribute to tobacco control efforts, especially through patient-level clinical interventions, when supported by a health care system and government that recognize and support tobacco control as a critical strategy for CVH promotion and CVD prevention. Understanding, supporting, and applying current and evolving policies, programs, and practices in tobacco prevention and control is the province of all health professionals, especially those concerned with CVH promotion and CVD prevention. A new tobacco control roadmap from the World Heart Federation provides a strong impetus to the needed interdisciplinary collaboration. PMID:27717667

Astrobiology: A Roadmap for Charting Life in the Universe

NASA Technical Reports Server (NTRS)

DesMarais, David J.; DeVincezi, D. (Technical Monitor)

2002-01-01

Astrobiology is the study of the origin, evolution and distribution of life in the universe. It provides a biological perspective to many areas of NASA research. It links such endeavors as the search for habitable planets, exploration missions to Mars and the outer Solar System, efforts to understand the origins and early evolution of life, and charting the potential of life to adapt to future challenges, both on Earth and in space. Astrobiology addresses the following three basic questions, which have been asked in some form for generations. How does life begin and evolve? Does life exist elsewhere in the universe? What is future of life on Earth and beyond? The NASA Astrobiology Roadmap provides guidance for research and technology development across several NASA Enterprises: Space Science, Earth Science, and the Human Exploration and Development of Space. The Roadmap is formulated in terms of eight Science Goals that outline key domains of investigation that might require perhaps decades of effort to consolidate. For each of these goals, Science Objectives outline more specific high priority near-term efforts for the next three to five years. These twenty objectives will be integrated with NASA strategic planning.

Technology Estimating: A Process to Determine the Cost and Schedule of Space Technology Research and Development

NASA Technical Reports Server (NTRS)

Cole, Stuart K.; Reeves, John D.; Williams-Byrd, Julie A.; Greenberg, Marc; Comstock, Doug; Olds, John R.; Wallace, Jon; DePasquale, Dominic; Schaffer, Mark

2013-01-01

NASA is investing in new technologies that include 14 primary technology roadmap areas, and aeronautics. Understanding the cost for research and development of these technologies and the time it takes to increase the maturity of the technology is important to the support of the ongoing and future NASA missions. Overall, technology estimating may help provide guidance to technology investment strategies to help improve evaluation of technology affordability, and aid in decision support. The research provides a summary of the framework development of a Technology Estimating process where four technology roadmap areas were selected to be studied. The framework includes definition of terms, discussion for narrowing the focus from 14 NASA Technology Roadmap areas to four, and further refinement to include technologies, TRL range of 2 to 6. Included in this paper is a discussion to address the evaluation of 20 unique technology parameters that were initially identified, evaluated and then subsequently reduced for use in characterizing these technologies. A discussion of data acquisition effort and criteria established for data quality are provided. The findings obtained during the research included gaps identified, and a description of a spreadsheet-based estimating tool initiated as a part of the Technology Estimating process.

Exploration Blueprint: Data Book

NASA Technical Reports Server (NTRS)

Drake, Bret G. (Editor)

2007-01-01

The material contained in this report was compiled to capture the work performed by the National Aeronautics and Space Administration's (NASA's) Exploration study team in the late 2002 timeframe. The "Exploration Blueprint Data Book" documents the analyses and findings of the 90-day Agency-wide study conducted from September - November 2002. During the summer of 2002, the NASA Deputy Administrator requested that a study be performed with the following objectives: (1) Develop the rationale for exploration beyond low-Earth orbit (2) Develop roadmaps for how to accomplish the first steps through humans to Mars (3) Develop design reference missions as a basis for the roadmaps 4) Make recommendations on what can be done now to effect this future This planning team, termed the Exploration Blueprint, performed architecture analyses to develop roadmaps for how to accomplish the first steps beyond LEO through the human exploration of Mars. The previous NASA Exploration Team activities laid the foundation and framework for development of NASA's Integrated Space Plan. The reference missions resulting from the analysis performed by the Exploration Blueprint team formed the basis for requirement definition, systems development, technology roadmapping, and risk assessments for future human exploration beyond low-Earth orbit. Emphasis was placed on developing recommendations on what could be done now to effect future exploration activities. The Exploration Blueprint team embraced the "Stepping Stone" approach to exploration where human and robotic activities are conducted through progressive expansion outward beyond low-Earth orbit. Results from this study produced a long-term strategy for exploration with near-term implementation plans, program recommendations, and technology investments. Specific results included the development of a common exploration crew vehicle concept, a unified space nuclear strategy, focused bioastronautics research objectives, and an integrated human and robotic exploration strategy. Recommendations from the Exploration Blueprint included the endorsement of the Nuclear Systems Initiative, augmentation of the bioastronautics research, a focused space transportation program including heavy-lift launch and a common exploration vehicle design for ISS and exploration missions, as well as an integrated human and robotic exploration strategy for Mars.

Exploration Blueprint: Data Book

NASA Astrophysics Data System (ADS)

Drake, Bret G.

2007-02-01

The material contained in this report was compiled to capture the work performed by the National Aeronautics and Space Administration's (NASA's) Exploration study team in the late 2002 timeframe. The "Exploration Blueprint Data Book" documents the analyses and findings of the 90-day Agency-wide study conducted from September - November 2002. During the summer of 2002, the NASA Deputy Administrator requested that a study be performed with the following objectives: (1) Develop the rationale for exploration beyond low-Earth orbit (2) Develop roadmaps for how to accomplish the first steps through humans to Mars (3) Develop design reference missions as a basis for the roadmaps 4) Make recommendations on what can be done now to effect this future This planning team, termed the Exploration Blueprint, performed architecture analyses to develop roadmaps for how to accomplish the first steps beyond LEO through the human exploration of Mars. The previous NASA Exploration Team activities laid the foundation and framework for development of NASA's Integrated Space Plan. The reference missions resulting from the analysis performed by the Exploration Blueprint team formed the basis for requirement definition, systems development, technology roadmapping, and risk assessments for future human exploration beyond low-Earth orbit. Emphasis was placed on developing recommendations on what could be done now to effect future exploration activities. The Exploration Blueprint team embraced the "Stepping Stone" approach to exploration where human and robotic activities are conducted through progressive expansion outward beyond low-Earth orbit. Results from this study produced a long-term strategy for exploration with near-term implementation plans, program recommendations, and technology investments. Specific results included the development of a common exploration crew vehicle concept, a unified space nuclear strategy, focused bioastronautics research objectives, and an integrated human and robotic exploration strategy. Recommendations from the Exploration Blueprint included the endorsement of the Nuclear Systems Initiative, augmentation of the bioastronautics research, a focused space transportation program including heavy-lift launch and a common exploration vehicle design for ISS and exploration missions, as well as an integrated human and robotic exploration strategy for Mars.

The European Hematology Association Roadmap for European Hematology Research: a consensus document.

PubMed

Engert, Andreas; Balduini, Carlo; Brand, Anneke; Coiffier, Bertrand; Cordonnier, Catherine; Döhner, Hartmut; de Wit, Thom Duyvené; Eichinger, Sabine; Fibbe, Willem; Green, Tony; de Haas, Fleur; Iolascon, Achille; Jaffredo, Thierry; Rodeghiero, Francesco; Salles, Gilles; Schuringa, Jan Jacob

2016-02-01

The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at €23 billion per year, a level of cost that is not matched in current European hematology research funding. In recent decades, hematology research has improved our fundamental understanding of the biology of blood disorders, and has improved diagnostics and treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap.The EHA Roadmap identifies nine 'sections' in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders.The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients. Copyright© Ferrata Storti Foundation.

The European Hematology Association Roadmap for European Hematology Research: a consensus document

PubMed Central

Engert, Andreas; Balduini, Carlo; Brand, Anneke; Coiffier, Bertrand; Cordonnier, Catherine; Döhner, Hartmut; de Wit, Thom Duyvené; Eichinger, Sabine; Fibbe, Willem; Green, Tony; de Haas, Fleur; Iolascon, Achille; Jaffredo, Thierry; Rodeghiero, Francesco; Salles, Gilles; Schuringa, Jan Jacob

2016-01-01

The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at €23 billion per year, a level of cost that is not matched in current European hematology research funding. In recent decades, hematology research has improved our fundamental understanding of the biology of blood disorders, and has improved diagnostics and treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap. The EHA Roadmap identifies nine ‘sections’ in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders. The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients. PMID:26819058

Linking Six Sigma to simulation: a new roadmap to improve the quality of patient care.

PubMed

Celano, Giovanni; Costa, Antonio; Fichera, Sergio; Tringali, Giuseppe

2012-01-01

Improving the quality of patient care is a challenge that calls for a multidisciplinary approach, embedding a broad spectrum of knowledge and involving healthcare professionals from diverse backgrounds. The purpose of this paper is to present an innovative approach that implements discrete-event simulation (DES) as a decision-supporting tool in the management of Six Sigma quality improvement projects. A roadmap is designed to assist quality practitioners and health care professionals in the design and successful implementation of simulation models within the define-measure-analyse-design-verify (DMADV) or define-measure-analyse-improve-control (DMAIC) Six Sigma procedures. A case regarding the reorganisation of the flow of emergency patients affected by vertigo symptoms was developed in a large town hospital as a preliminary test of the roadmap. The positive feedback from professionals carrying out the project looks promising and encourages further roadmap testing in other clinical settings. The roadmap is a structured procedure that people involved in quality improvement can implement to manage projects based on the analysis and comparison of alternative scenarios. The role of Six Sigma philosophy in improvement of the quality of healthcare services is recognised both by researchers and by quality practitioners; discrete-event simulation models are commonly used to improve the key performance measures of patient care delivery. The two approaches are seldom referenced and implemented together; however, they could be successfully integrated to carry out quality improvement programs. This paper proposes an innovative approach to bridge the gap and enrich the Six Sigma toolbox of quality improvement procedures with DES.

Leading from the Front of the Classroom: A Roadmap to Teacher Leadership That Works

ERIC Educational Resources Information Center

Aspen Institute, 2014

2014-01-01

In this paper, Leading Educators and the Aspen Institute propose a roadmap to empower teachers to lead from the front of the classroom. This paper outlines key phases that system administrators will need to consider as they build teacher leadership systems that address their highest priorities. For each phase, the Aspen Institute offers a…

A Review of Agile and Lean Manufacturing as Issues in Selected International and National Research and Development Programs and Roadmaps

ERIC Educational Resources Information Center

Castro, Helio; Putnik, Goran D.; Shah, Vaibhav

2012-01-01

Purpose: The aim of this paper is to analyze international and national research and development (R&D) programs and roadmaps for the manufacturing sector, presenting how agile and lean manufacturing models are addressed in these programs. Design/methodology/approach: In this review, several manufacturing research and development programs and…

Roadmap for High School Feedback Reports: Key Focus Areas to Ensure Quality Implementation. Data for Action

ERIC Educational Resources Information Center

Data Quality Campaign, 2014

2014-01-01

High school feedback reports let school and district leaders know where their students go after graduation and how well they are prepared for college and beyond. This roadmap discusses the seven key focus areas the Data Quality Campaign (DQC) recommends states work on to ensure quality implementation of high school feedback reports.

Reducing Human Radiation Risks on Deep Space Missions

DTIC Science & Technology

2017-09-01

Roadmap (2016). .........................................................108 Figure 53. Risk Assessment for Acute Radiation Syndrome Due to SPEs...Risk of Acute Radiation Syndromes Due to Solar Particle Events Figure 53 highlights the fact that acute radiation syndrome is a short-term risk...acceptable for long-term missions. Figure 53. Risk Assessment for Acute Radiation Syndrome Due to SPEs. Source: NASA Human Research Roadmap (2016

Roadmap for Educator Licensure Policy Addressing Data Literacy: Key Focus Areas to Ensure Quality. Data for Action

ERIC Educational Resources Information Center

Data Quality Campaign, 2014

2014-01-01

State licensure polices are meant to provide teacher preparation programs with direction about the skills teachers need to be qualified to teach, including skills to use data. This roadmap discusses the 10 key data use skills that states can include in a licensure policy with a quality focus on effective data use.

Roadmap for Early Childhood and K-12 Data Linkages: Key Focus Areas to Ensure Quality Implementation. Quality Implementation Roadmaps

ERIC Educational Resources Information Center

Data Quality Campaign, 2016

2016-01-01

Every state can create secure, robust linkages between early childhood and K-12 data systems, and effectively use the information from these linkages to implement initiatives to support programs and children, answer key policy questions, and be transparent about how the state's early childhood investments prepare students for success in school and…

Unmanned Systems Integrated Roadmap FY2011-2036

DTIC Science & Technology

2011-10-01

neuroscience , and cognition science may lead to the implementation of some of the most critical functionalities of heterogeneous, sensor net...Roadmap FY2011-2036 69 7.4.5.4 Encryption Unmanned systems incorporation of data encryption includes National Security Agency ( NSA ) Type 1 (for...see DODI 4660). Numerous other policies and initiatives are under development within the NSA to significantly streamline the certification processes

Cellular Therapies Clinical Research Roadmap: lessons learned on how to move a cellular therapy into a clinical trial.

PubMed

Ouseph, Stacy; Tappitake, Darah; Armant, Myriam; Wesselschmidt, Robin; Derecho, Ivy; Draxler, Rebecca; Wood, Deborah; Centanni, John M

2015-04-01

A clinical research roadmap has been developed as a resource for researchers to identify critical areas and potential pitfalls when transitioning a cellular therapy product from the research laboratory, by means of an Investigational New Drug (IND) application, into early-phase clinical trials. The roadmap describes four key areas: basic and preclinical research, resource development, translational research and Good Manufacturing Practice (GMP) and IND assembly and submission. Basic and preclinical research identifies a new therapeutic concept and demonstrates its potential value with the use of a model of the relevant disease. During resource development, the appropriate specialists and the required expertise to bring this product into the clinic are identified (eg, researchers, regulatory specialists, GMP manufacturing staff, clinicians and clinical trials staff, etc). Additionally, the funds required to achieve this goal (or a plan to procure them) are identified. In the next phase, the plan to translate the research product into a clinical-grade therapeutic is developed. Finally regulatory approval to start the trial must be obtained. In the United States, this is done by filing an IND application with the Food and Drug Administration. The National Heart, Lung and Blood Institute-funded Production Assistance for Cellular Therapies program has facilitated the transition of a variety of cellular therapy products from the laboratory into Phase1/2 trials. The five Production Assistance for Cellular Therapies facilities have assisted investigators by performing translational studies and GMP manufacturing to ensure that cellular products met release specifications and were manufactured safely, reproducibly and at the appropriate scale. The roadmap resulting from this experience is the focus of this article. Copyright © 2015 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.

Roadmap for the protection of disaster research participants: findings from the World Trade Center Evacuation Study.

PubMed

Qureshi, Kristine A; Gershon, Robyn R M; Smailes, Elizabeth; Raveis, Victoria H; Murphy, Bridgette; Matzner, Frederick; Fleischman, Alan R

2007-01-01

This report addresses the development, implementation, and evaluation of a protocol designed to protect participants from inadvertent emotional harm or further emotional trauma due to their participation in the World Trade Center Evacuation (WTCE) Study research project. This project was designed to identify the individual, organizational, and structural (environmental) factors associated with evacuation from the World Trade Center Towers 1 and 2 on 11 September 2001. Following published recommended practices for protecting potentially vulnerable disaster research participants, protective strategies and quality assurance processes were implemented and evaluated, including an assessment of the impact of participation on study subjects enrolled in the qualitative phase of the WTCE Study. The implementation of a protocol designed to protect disaster study participants from further emotional trauma was feasible and effective in minimizing risk and monitoring for psychological injury associated with study participation. Details about this successful strategy provide a roadmap that can be applied in other post-disaster research investigations.

The 2016 oxide electronic materials and oxide interfaces roadmap

NASA Astrophysics Data System (ADS)

Lorenz, M.; Ramachandra Rao, M. S.; Venkatesan, T.; Fortunato, E.; Barquinha, P.; Branquinho, R.; Salgueiro, D.; Martins, R.; Carlos, E.; Liu, A.; Shan, F. K.; Grundmann, M.; Boschker, H.; Mukherjee, J.; Priyadarshini, M.; DasGupta, N.; Rogers, D. J.; Teherani, F. H.; Sandana, E. V.; Bove, P.; Rietwyk, K.; Zaban, A.; Veziridis, A.; Weidenkaff, A.; Muralidhar, M.; Murakami, M.; Abel, S.; Fompeyrine, J.; Zuniga-Perez, J.; Ramesh, R.; Spaldin, N. A.; Ostanin, S.; Borisov, V.; Mertig, I.; Lazenka, V.; Srinivasan, G.; Prellier, W.; Uchida, M.; Kawasaki, M.; Pentcheva, R.; Gegenwart, P.; Miletto Granozio, F.; Fontcuberta, J.; Pryds, N.

2016-11-01

Oxide electronic materials provide a plethora of possible applications and offer ample opportunity for scientists to probe into some of the exciting and intriguing phenomena exhibited by oxide systems and oxide interfaces. In addition to the already diverse spectrum of properties, the nanoscale form of oxides provides a new dimension of hitherto unknown phenomena due to the increased surface-to-volume ratio. Oxide electronic materials are becoming increasingly important in a wide range of applications including transparent electronics, optoelectronics, magnetoelectronics, photonics, spintronics, thermoelectrics, piezoelectrics, power harvesting, hydrogen storage and environmental waste management. Synthesis and fabrication of these materials, as well as processing into particular device structures to suit a specific application is still a challenge. Further, characterization of these materials to understand the tunability of their properties and the novel properties that evolve due to their nanostructured nature is another facet of the challenge. The research related to the oxide electronic field is at an impressionable stage, and this has motivated us to contribute with a roadmap on ‘oxide electronic materials and oxide interfaces’. This roadmap envisages the potential applications of oxide materials in cutting edge technologies and focuses on the necessary advances required to implement these materials, including both conventional and novel techniques for the synthesis, characterization, processing and fabrication of nanostructured oxides and oxide-based devices. The contents of this roadmap will highlight the functional and correlated properties of oxides in bulk, nano, thin film, multilayer and heterostructure forms, as well as the theoretical considerations behind both present and future applications in many technologically important areas as pointed out by Venkatesan. The contributions in this roadmap span several thematic groups which are represented by the following authors: novel field effect transistors and bipolar devices by Fortunato, Grundmann, Boschker, Rao, and Rogers; energy conversion and saving by Zaban, Weidenkaff, and Murakami; new opportunities of photonics by Fompeyrine, and Zuniga-Perez; multiferroic materials including novel phenomena by Ramesh, Spaldin, Mertig, Lorenz, Srinivasan, and Prellier; and concepts for topological oxide electronics by Kawasaki, Pentcheva, and Gegenwart. Finally, Miletto Granozio presents the European action ‘towards oxide-based electronics’ which develops an oxide electronics roadmap with emphasis on future nonvolatile memories and the required technologies. In summary, we do hope that this oxide roadmap appears as an interesting up-to-date snapshot on one of the most exciting and active areas of solid state physics, materials science, and chemistry, which even after many years of very successful development shows in short intervals novel insights and achievements. Guest editors: M S Ramachandra Rao and Michael Lorenz

Chicago Ebola Response Network (CERN): A Citywide Cross-hospital Collaborative for Infectious Disease Preparedness.

PubMed

Lateef, Omar; Hota, Bala; Landon, Emily; Kociolek, Larry K; Morita, Julie; Black, Stephanie; Noskin, Gary; Kelleher, Michael; Curell, Krista; Galat, Amy; Ansell, David; Segreti, John; Weber, Stephen G

2015-11-15

The 2014-2015 Ebola virus disease (EVD) epidemic and international public health emergency has been referred to as a "black swan" event, or an event that is unlikely, hard to predict, and highly impactful once it occurs. The Chicago Ebola Response Network (CERN) was formed in response to EVD and is capable of receiving and managing new cases of EVD, while also laying the foundation for a public health network that can anticipate, manage, and prevent the next black swan public health event. By sharing expertise, risk, and resources among 4 major academic centers, Chicago created a sustainable network to respond to the latest in a series of public health emergencies. In this respect, CERN is a roadmap for how a region can prepare to respond to public health emergencies, thereby preventing negative impacts through planning and implementation. © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

A New Security Paradigm for Anti-Counterfeiting: Guidelines and an Implementation Roadmap

NASA Astrophysics Data System (ADS)

Lehtonen, Mikko

Product counterfeitingand piracy continue to plague brand and trademark owners across industry sectors. This chapter analyses the reasons for ineffectiveness of past technical anti-counterfeitingstrategies and formulates managerial guidelines for effective use of RFID in anti-counterfeiting. An implementation roadmap toward secure authentication of products tagged with EPC Gen-2 tags is proposed and possible supply chain locations for product checks are discussed.

The ASTRONET Infrastructure Roadmap: A Twenty Year Strategy for European Astronomy

NASA Astrophysics Data System (ADS)

Bode, M.; Monnet, G.

2008-12-01

The process followed by ASTRONET to build a long-term strategy for European astronomy is presented. The main conclusions and priorities given in the recently unveiled report on the Infrastructure Roadmap for the next 20 years, following the establishment of a Science Vision last year, are summarised. These reports together hopefully represent a blueprint for a bright future for European astronomy.

Sol-Terra - AN Operational Space Weather Forecasting Model Framework

NASA Astrophysics Data System (ADS)

Bisi, M. M.; Lawrence, G.; Pidgeon, A.; Reid, S.; Hapgood, M. A.; Bogdanova, Y.; Byrne, J.; Marsh, M. S.; Jackson, D.; Gibbs, M.

2015-12-01

The SOL-TERRA project is a collaboration between RHEA Tech, the Met Office, and RAL Space funded by the UK Space Agency. The goal of the SOL-TERRA project is to produce a Roadmap for a future coupled Sun-to-Earth operational space weather forecasting system covering domains from the Sun down to the magnetosphere-ionosphere-thermosphere and neutral atmosphere. The first stage of SOL-TERRA is underway and involves reviewing current models that could potentially contribute to such a system. Within a given domain, the various space weather models will be assessed how they could contribute to such a coupled system. This will be done both by reviewing peer reviewed papers, and via direct input from the model developers to provide further insight. Once the models have been reviewed then the optimal set of models for use in support of forecast-based SWE modelling will be selected, and a Roadmap for the implementation of an operational forecast-based SWE modelling framework will be prepared. The Roadmap will address the current modelling capability, knowledge gaps and further work required, and also the implementation and maintenance of the overall architecture and environment that the models will operate within. The SOL-TERRA project will engage with external stakeholders in order to ensure independently that the project remains on track to meet its original objectives. A group of key external stakeholders have been invited to provide their domain-specific expertise in reviewing the SOL-TERRA project at critical stages of Roadmap preparation; namely at the Mid-Term Review, and prior to submission of the Final Report. This stakeholder input will ensure that the SOL-TERRA Roadmap will be enhanced directly through the input of modellers and end-users. The overall goal of the SOL-TERRA project is to develop a Roadmap for an operational forecast-based SWE modelling framework with can be implemented within a larger subsequent activity. The SOL-TERRA project is supported within the UK Space Agency's National Space Technology Programme under contract number RP10G0348A03.

National Aeronautics and Space Administration (NASA) Environmental Control and Life Support (ECLS) Integrated Roadmap Development

NASA Technical Reports Server (NTRS)

Metcalf, Jordan; Peterson, Laurie; Carrasquillo, Robyn; Bagdigian, Robert

2011-01-01

At present, NASA has considered a number of future human space exploration mission concepts . Yet, detailed mission requirements and vehicle architectures remain mostly undefined, making technology investment strategies difficult to develop and sustain without a top-level roadmap to serve as a guide. This paper documents a roadmap for development of Environmental Control and Life Support Systems (ECLSS) capabilities required to enhance the long-term operation of the International Space Station (ISS) as well as enable beyond-Low Earth Orbit (LEO) human exploration missions. Three generic mission types were defined to serve as a basis for developing a prioritized list of needed capabilities and technologies. Those are 1) a short duration micro gravity mission; 2) a long duration transit microgravity mission; and 3) a long duration surface exploration mission. To organize the effort, ECLSS was categorized into three major functional groups (atmosphere, water, and solid waste management) with each broken down into sub-functions. The ability of existing state-of-the-art (SOA) technologies to meet the functional needs of each of the three mission types was then assessed by NASA subject matter experts. When SOA capabilities were deemed to fall short of meeting the needs of one or more mission types, those gaps were prioritized in terms of whether or not the corresponding capabilities enable or enhance each of the mission types. The result was a list of enabling and enhancing capabilities needs that can be used to guide future ECLSS development, as well as a list of existing hardware that is ready to go for exploration-class missions. A strategy to fulfill those needs over time was then developed in the form of a roadmap. Through execution of this roadmap, the hardware and technologies intended to meet exploration needs will, in many cases, directly benefit the ISS operational capability, benefit the Multi-Purpose Crew Vehicle (MPCV), and guide long-term technology investments for longer duration missions The final product of this paper is an agreed-to ECLSS roadmap detailing ground and flight testing to support the three mission scenarios previously mentioned. This information will also be used to develop the integrated NASA budget submit in January 2012.

Scientific and technical challenges on the road towards fusion electricity

NASA Astrophysics Data System (ADS)

Donné, A. J. H.; Federici, G.; Litaudon, X.; McDonald, D. C.

2017-10-01

The goal of the European Fusion Roadmap is to deliver fusion electricity to the grid early in the second half of this century. It breaks the quest for fusion energy into eight missions, and for each of them it describes a research and development programme to address all the open technical gaps in physics and technology and estimates the required resources. It points out the needs to intensify industrial involvement and to seek all opportunities for collaboration outside Europe. The roadmap covers three periods: the short term, which runs parallel to the European Research Framework Programme Horizon 2020, the medium term and the long term. ITER is the key facility of the roadmap as it is expected to achieve most of the important milestones on the path to fusion power. Thus, the vast majority of present resources are dedicated to ITER and its accompanying experiments. The medium term is focussed on taking ITER into operation and bringing it to full power, as well as on preparing the construction of a demonstration power plant DEMO, which will for the first time demonstrate fusion electricity to the grid around the middle of this century. Building and operating DEMO is the subject of the last roadmap phase: the long term. Clearly, the Fusion Roadmap is tightly connected to the ITER schedule. Three key milestones are the first operation of ITER, the start of the DT operation in ITER and reaching the full performance at which the thermal fusion power is 10 times the power put in to the plasma. The Engineering Design Activity of DEMO needs to start a few years after the first ITER plasma, while the start of the construction phase will be a few years after ITER reaches full performance. In this way ITER can give viable input to the design and development of DEMO. Because the neutron fluence in DEMO will be much higher than in ITER, it is important to develop and validate materials that can handle these very high neutron loads. For the testing of the materials, a dedicated 14 MeV neutron source is needed. This DEMO Oriented Neutron Source (DONES) is therefore an important facility to support the fusion roadmap.

Approaches for Establishing Clinically Relevant Dissolution Specifications for Immediate Release Solid Oral Dosage Forms.

PubMed

Hermans, Andre; Abend, Andreas M; Kesisoglou, Filippos; Flanagan, Talia; Cohen, Michael J; Diaz, Dorys A; Mao, Y; Zhang, Limin; Webster, Gregory K; Lin, Yiqing; Hahn, David A; Coutant, Carrie A; Grady, Haiyan

2017-11-01

This manuscript represents the perspective of the Dissolution Analytical Working Group of the IQ Consortium. The intent of this manuscript is to highlight the challenges of, and to provide a recommendation on, the development of clinically relevant dissolution specifications (CRS) for immediate release (IR) solid oral dosage forms. A roadmap toward the development of CRS for IR products containing active ingredients with a non-narrow therapeutic window is discussed, within the context of mechanistic dissolution understanding, supported by in-human pharmacokinetic (PK) data. Two case studies present potential outcomes of following the CRS roadmap and setting dissolution specifications. These cases reveal some benefits and challenges of pursuing CRS with additional PK data, in light of current regulatory positions, including that of the US Food and Drug Administration (FDA), who generally favor this approach, but with the understanding that both industry and regulatory agency perspectives are still evolving in this relatively new field. The CRS roadmap discussed in this manuscript also describes a way to develop clinically relevant dissolution specifications based primarily on dissolution data for batches used in pivotal clinical studies, acknowledging that not all IR product development efforts need to be supported by additional PK studies, albeit with the associated risk of potentially unnecessarily tight manufacturing controls. Recommendations are provided on what stages during the life cycle investment into in vivo studies may be valuable. Finally, the opportunities for CRS within the context of post-approval changes, Modeling and Simulation (M&S), and the application of biowaivers, are briefly discussed.

Secondary-School Earth Science: A Column for Teachers.

ERIC Educational Resources Information Center

Christman, Robert

1984-01-01

Six secondary school teachers describe their most successful earth science investigations. They include various outdoor field activities, road-map reading skills, student-prepared and conducted investigations, and use of several materials for studying volcanoes. (JN)

Roadmap on optical energy conversion

NASA Astrophysics Data System (ADS)

Boriskina, Svetlana V.; Green, Martin A.; Catchpole, Kylie; Yablonovitch, Eli; Beard, Matthew C.; Okada, Yoshitaka; Lany, Stephan; Gershon, Talia; Zakutayev, Andriy; Tahersima, Mohammad H.; Sorger, Volker J.; Naughton, Michael J.; Kempa, Krzysztof; Dagenais, Mario; Yao, Yuan; Xu, Lu; Sheng, Xing; Bronstein, Noah D.; Rogers, John A.; Alivisatos, A. Paul; Nuzzo, Ralph G.; Gordon, Jeffrey M.; Wu, Di M.; Wisser, Michael D.; Salleo, Alberto; Dionne, Jennifer; Bermel, Peter; Greffet, Jean-Jacques; Celanovic, Ivan; Soljacic, Marin; Manor, Assaf; Rotschild, Carmel; Raman, Aaswath; Zhu, Linxiao; Fan, Shanhui; Chen, Gang

2016-07-01

For decades, progress in the field of optical (including solar) energy conversion was dominated by advances in the conventional concentrating optics and materials design. In recent years, however, conceptual and technological breakthroughs in the fields of nanophotonics and plasmonics combined with a better understanding of the thermodynamics of the photon energy-conversion processes reshaped the landscape of energy-conversion schemes and devices. Nanostructured devices and materials that make use of size quantization effects to manipulate photon density of states offer a way to overcome the conventional light absorption limits. Novel optical spectrum splitting and photon-recycling schemes reduce the entropy production in the optical energy-conversion platforms and boost their efficiencies. Optical design concepts are rapidly expanding into the infrared energy band, offering new approaches to harvest waste heat, to reduce the thermal emission losses, and to achieve noncontact radiative cooling of solar cells as well as of optical and electronic circuitries. Light-matter interaction enabled by nanophotonics and plasmonics underlie the performance of the third- and fourth-generation energy-conversion devices, including up- and down-conversion of photon energy, near-field radiative energy transfer, and hot electron generation and harvesting. Finally, the increased market penetration of alternative solar energy-conversion technologies amplifies the role of cost-driven and environmental considerations. This roadmap on optical energy conversion provides a snapshot of the state of the art in optical energy conversion, remaining challenges, and most promising approaches to address these challenges. Leading experts authored 19 focused short sections of the roadmap where they share their vision on a specific aspect of this burgeoning research field. The roadmap opens up with a tutorial section, which introduces major concepts and terminology. It is our hope that the roadmap will serve as an important resource for the scientific community, new generations of researchers, funding agencies, industry experts, and investors.

Roadmap to achieve 25% hypertension control in Africa by 2025

PubMed Central

Dzudie, Anastase; Kingue, Samuel; Dzudie, Anastase; Sliwa, Karen; Mayosi, Bongani; Dzudie, Anastase; Sliwa, Karen; Rayner, Brian; Ojji, Dike; Schutte, Aletta E; Twagirumukiza, Marc; Damasceno, Albertino; Ba, Seringe Abdou; Kane, Abdoul; Kramoh, Euloge; Kacou, Jean Baptiste Anzouan; Onwubere, Basden; Cornick, Ruth; Anisiuba, Benedict; Mocumbi, Ana Olga; Ogola, Elijah; Awad, Mohamed; Nel, George; Otieno, Harun; Toure, Ali Ibrahim; Kengne, Andre Pascal; Perel, Pablo; Adler, Alm; Poulter, Neil

2017-01-01

Summary Background and aim: The Pan-African Society of Cardiology (PASCAR) has identified hypertension as the highest area of priority for action to reduce heart disease and stroke on the continent. The aim of this PASCAR roadmap on hypertension was to develop practical guidance on how to implement strategies that translate existing knowledge into effective action and improve detection, treatment and control of hypertension and cardiovascular health in sub-Saharan Africa (SSA) by the year 2025. Methods: Development of this roadmap started with the creation of a consortium of experts with leadership skills in hypertension. In 2014, experts in different fields, including physicians and non-physicians, were invited to join. Via faceto- face meetings and teleconferences, the consortium made a situation analysis, set a goal, identified roadblocks and solutions to the management of hypertension and customised the World Heart Federation roadmap to Africa. Results: Hypertension is a major crisis on the continent but very few randomised, controlled trials have been conducted on its management. Also, only 25.8% of the countries have developed or adopted guidelines for the management of hypertension. Other major roadblocks are either government and health-system related or healthcare professional or patient related. The PASCAR hypertension task force identified a 10-point action plan to be implemented by African ministries of health to achieve 25% control of hypertension in Africa by 2025. Conclusions: Hypertension affects millions of people in SSA and if left untreated, is a major cause of heart disease and stroke. Very few SSA countries have a clear hypertension policy. This PASCAR roadmap identifies practical and effective solutions that would improve detection, treatment and control of hypertension on the continent and could be implemented as is or adapted to specific national settings. PMID:28906541

World Health Organization Public Health Model: A Roadmap for Palliative Care Development.

PubMed

Callaway, Mary V; Connor, Stephen R; Foley, Kathleen M

2018-02-01

The Open Society Foundation's International Palliative Care Initiative (IPCI) began to support palliative care development in Central and Eastern Europe and the Former Soviet Union in 1999. Twenty-five country representatives were invited to discuss the need for palliative care in their countries and to identify key areas that should be addressed to improve the care of adults and children with life-limiting illnesses. As a public health concern, progress in palliative care requires integration into health policy, education and training of health care professionals, availability of essential pain relieving medications, and health care services. IPCI created the Palliative Care Roadmap to serve as a model for government and/or nongovernment organizations to use to frame the necessary elements and steps for palliative care integration. The roadmap includes the creation of multiple Ministry of Health-approved working groups to address: palliative care inclusion in national health policy, legislation, and finance; availability of essential palliative care medications, especially oral opioids; education and training of health care professionals; and the implementation of palliative care services at home or in inpatient settings for adults and children. Each working group is tasked with developing a pathway with multiple signposts as indicators of progress made. The roadmap may be entered at different signposts depending upon the state of palliative care development in the country. The progress of the working groups often takes place simultaneously but at variable rates. Based on our experience, the IPCI Roadmap is one possible framework for palliative care development in resource constrained countries but requires both health care professional engagement and political will for progress to be made. Copyright © 2017. Published by Elsevier Inc.

Innovation and development of exhibition electronic-commerce based on the properties of electronic-commerce

NASA Astrophysics Data System (ADS)

Zhang, Jiankang

2017-06-01

There are two roadmaps of accomplishing exhibition electronic-commerce innovation and development. The first roadmap is that the exhibition organizers should seek mutual benefit cooperation with professional electronic-commerce platform of correspondent area with exhibition projects, thus help exhibitors realize their market object. The second roadmap is to promote innovation and development of electronic-commerce (Business-to-Customer) between both exhibitors and purchasers. Exhibition electronic-commerce must focus on innovative development in the following functions: market research and information service; advertising and business negotiation; online trading and online payment. With the aid of electronic-commerce, exhibition enterprise could have distinctive strengths such as transactions with virtualization, transparency, high efficiency and low cost, enhancing market link during enterprise research and development, promoting the efficiency of internal team collaboration and the individuation of external service, and optimizing resource allocation.

Proposed roadmap for overcoming legal and financial obstacles to carbon capture and sequestration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jacobs, Wendy; Chohen, Leah; Kostakidis-Lianos, Leah

Many existing proposals either lack sufficient concreteness to make carbon capture and geological sequestration (CCGS) operational or fail to focus on a comprehensive, long term framework for its regulation, thus failing to account adequately for the urgency of the issue, the need to develop immediate experience with large scale demonstration projects, or the financial and other incentives required to launch early demonstration projects. We aim to help fill this void by proposing a roadmap to commercial deployment of CCGS in the United States.This roadmap focuses on the legal and financial incentives necessary for rapid demonstration of geological sequestration in themore » absence of national restrictions on CO2 emissions. It weaves together existing federal programs and financing opportunities into a set of recommendations for achieving commercial viability of geological sequestration.« less

Spacecraft Onboard Interface Services: Current Status and Roadmap

NASA Astrophysics Data System (ADS)

Prochazka, Marek; Lopez Trescastro, Jorge; Krueger, Sabine

2016-08-01

Spacecraft Onboard Interface Services (SOIS) is a set of CCSDS standards defining communication stack services to interact with hardware equipment onboard spacecraft. In 2014 ESA kicked off three parallel activities to critically review the SOIS standards, use legacy spacecraft flight software (FSW), make it compliant to a preselected subset of SOIS standards and make performance and architecture assessment. As a part of the three parallel activities, led by Airbus DS Toulouse, OHB Bremen and Thales Alenia Space Cannes respectively, it was to provide feedback back to ESA and CCSDS and also to propose a roadmap of transition towards an operational FSW system fully compliant to applicable SOIS standards. The objective of the paper is twofold: Firstly it is to summarise main results of the three parallel activities and secondly, based on the results, to propose a roadmap for the future.

Science and technology roadmap for graphene, related two-dimensional crystals, and hybrid systems

NASA Astrophysics Data System (ADS)

Ferrari, Andrea C.; Bonaccorso, Francesco; Fal'Ko, Vladimir; Novoselov, Konstantin S.; Roche, Stephan; Bøggild, Peter; Borini, Stefano; Koppens, Frank H. L.; Palermo, Vincenzo; Pugno, Nicola; Garrido, José A.; Sordan, Roman; Bianco, Alberto; Ballerini, Laura; Prato, Maurizio; Lidorikis, Elefterios; Kivioja, Jani; Marinelli, Claudio; Ryhänen, Tapani; Morpurgo, Alberto; Coleman, Jonathan N.; Nicolosi, Valeria; Colombo, Luigi; Fert, Albert; Garcia-Hernandez, Mar; Bachtold, Adrian; Schneider, Grégory F.; Guinea, Francisco; Dekker, Cees; Barbone, Matteo; Sun, Zhipei; Galiotis, Costas; Grigorenko, Alexander N.; Konstantatos, Gerasimos; Kis, Andras; Katsnelson, Mikhail; Vandersypen, Lieven; Loiseau, Annick; Morandi, Vittorio; Neumaier, Daniel; Treossi, Emanuele; Pellegrini, Vittorio; Polini, Marco; Tredicucci, Alessandro; Williams, Gareth M.; Hee Hong, Byung; Ahn, Jong-Hyun; Min Kim, Jong; Zirath, Herbert; van Wees, Bart J.; van der Zant, Herre; Occhipinti, Luigi; Di Matteo, Andrea; Kinloch, Ian A.; Seyller, Thomas; Quesnel, Etienne; Feng, Xinliang; Teo, Ken; Rupesinghe, Nalin; Hakonen, Pertti; Neil, Simon R. T.; Tannock, Quentin; Löfwander, Tomas; Kinaret, Jari

2015-03-01

We present the science and technology roadmap for graphene, related two-dimensional crystals, and hybrid systems, targeting an evolution in technology, that might lead to impacts and benefits reaching into most areas of society. This roadmap was developed within the framework of the European Graphene Flagship and outlines the main targets and research areas as best understood at the start of this ambitious project. We provide an overview of the key aspects of graphene and related materials (GRMs), ranging from fundamental research challenges to a variety of applications in a large number of sectors, highlighting the steps necessary to take GRMs from a state of raw potential to a point where they might revolutionize multiple industries. We also define an extensive list of acronyms in an effort to standardize the nomenclature in this emerging field.

The Research Plan: Closing the ExMC Med02 "Pharmacy" Gap

NASA Technical Reports Server (NTRS)

Daniels, Vernie; Bayuse, Tina; Mulcahy, Robert; Shah, Ronak; Antonsen, Erik

2017-01-01

HRP Human Research Roadmap: Risk and Gap Risk of Adverse Health Outcomes and Decrements in Performance due to Inflight Medical Conditions. Med02 "Pharmacy" Gap: We do not have the capability to provide a safe and effective medication formulary for exploration missions delivering a recommendation for a chemically stable, safe, and effective medication formulary that will support the operational needs of exploration space missions research strategy evidence-based formulary and models innovative analytical tools and methodologies novel treatments and preventive measures Planned review by a panel of experts from the pharmaceutical industry, regulatory, and academic scientific communities Formulary Selection Formulary Potency and Shelf life Formulary Safety and Toxicity Novel Technology Proof-of-Concept Portable real-time chemical analysis Innovative drug development / design

Novel Musculoskeletal Loading System for Small Exercise Devices

NASA Technical Reports Server (NTRS)

Downs, Meghan; Newby, Nate; Trinh, Tinh; Hanson, Andrea

2016-01-01

Long duration spaceflight places astronauts at increased risk for muscle strain and bone fracture upon return to a 1-g or partial gravity environment. Functionally limiting decrements in musculoskeletal health are likely during Mars proving-ground and Earth-independent missions given extended transit times and the vehicle limitations for exercise devices (low-mass, small volume, little to no power). This is particularly alarming for exploration missions because astronauts will be required to perform novel and physically demanding tasks (i.e. vehicle egress, exploration, and habitat building activities) on unfamiliar terrain. Accordingly, NASA's exploration roadmap identifies the need for development of small exercise equipment that can prevent musculoskeletal atrophy and has the ability to assess musculoskeletal health at multiple time points during long-duration missions.

NASA Astrophysics Technology Needs

NASA Technical Reports Server (NTRS)

Stahl, H. Philip

2012-01-01

July 2010, NASA Office of Chief Technologist (OCT) initiated an activity to create and maintain a NASA integrated roadmap for 15 key technology areas which recommend an overall technology investment strategy and prioritize NASA?s technology programs to meet NASA?s strategic goals. Science Instruments, Observatories and Sensor Systems(SIOSS) roadmap addresses technology needs to achieve NASA?s highest priority objectives -- not only for the Science Mission Directorate (SMD), but for all of NASA.

2007 Precision Strike PEO Summer Forum - Joint Perspectives on Precision Engagement

DTIC Science & Technology

2007-07-11

Status,” Colonel Richard Justice, USAF—Commander of the Miniature Munitions Systems Group (MMSG), Eglin Air Force Base “Unmanned Systems (UAS) Roadmap...Role in the Roadmap Implementation Methods & Processes Working Group Issues delineated in Implementation Plan form basis for JTEM methodology...Test and Evaluation JMETC – Joint Mission Environment Test Capability WG – Working Group DOT&E AT&L DOT&E Unclassified 5 Background: JTEM Problem

Operational Resiliency Management: An Introduction to the Resiliency Engineering Framework

DTIC Science & Technology

2006-09-20

Maturity Model Integration (CMMI) . 5 © 2006 Carnegie Mellon University y FRB Bus Con Conference 2006 Managing Today’s Operational Risk Challenges ...Bus Con Conference 2006 A model is needed to. . . Identify and prioritize risk exposures Define a process improvement roadmap Measure and facilitate...University y FRB Bus Con Conference 2006 Why use a “model” approach? Provides an operational risk roadmap Vendor-neutral, standardized, unbiased

U.S. Geological Survey Unmanned Aircraft Systems (UAS) Roadmap 2014

USGS Publications Warehouse

Cress, Jill J.; Hutt, Michael E.; Sloan, Jeff L.; Bauer, Mark A.; Feller, Mark R.; Goplen, Susan E.

2015-01-01

This Roadmap provides operational procedures and lessons learned from completed proof-of-concept UAS missions in areas such as wildlife management, resource monitoring, and public land inspections. This information provides not only an implementation framework but can also help increase the awareness by resource managers, scientists, and others of the ability of UAS technology to advance data quality, improve personnel safety, and reduce data acquisition costs.

The US Army Corps of Engineers Roadmap for Life-Cycle Building Information Modeling (BIM). Supplement 2 - BIM Implementation Guide for Military Construction (MILCON) Projects Using the Bentley Platform

DTIC Science & Technology

2012-11-01

Building Information Modeling ( BIM ...12-2, Supplement 2 November 2012 The US Army Corps of Engineers Roadmap for Life-Cycle Building Information Modeling ( BIM ) Supplement 2 – BIM ...39180 ERDC SR-12-2, Supplement 2 (November 2012) ii Abstract Building Information Modeling ( BIM ) technology has rapidly gained ac-

The US Army Corps of Engineers Roadmap for Life-Cycle Building Information Modeling (BIM). Supplement 1- BIM Implementation Guide for Military Construction (MILCON) Projects Using the Autodesk Platform

DTIC Science & Technology

2012-11-01

Building Information Modeling ( BIM ...12-2, Supplement 1 November 2012 The US Army Corps of Engineers Roadmap for Life-Cycle Building Information Modeling ( BIM ) Supplement 1 – BIM ...ERDC SR-12-2, Supplement 1 (November 2012) ii Abstract Building Information Modeling ( BIM ) technology has rapidly gained ac- ceptance throughout

EUROGIN 2014 Roadmap: Differences in HPV infection natural history, transmission, and HPV-related cancer incidence by gender and anatomic site of infection

PubMed Central

Giuliano, Anna R.; Nyitray, Alan G.; Kreimer, Aimée R.; Pierce Campbell, Christine M.; Goodman, Marc T.; Sudenga, Staci L.; Monsonego, Joseph; Franceschi, Silvia

2014-01-01

Human papillomaviruses (HPVs) cause cancer at multiple anatomic sites in men and women, including cervical, oropharyngeal, anal, vulvar, and vaginal cancers in women and oropharyngeal, anal, and penile cancers in men. In this EUROGIN 2014 roadmap, differences in HPV-related cancer and infection burden by gender and anatomic site are reviewed. The proportion of cancers attributable to HPV varies by anatomic site, with nearly 100% of cervical, 88% of anal, and less than 50% of lower genital tract and oropharyngeal cancers attributable to HPV, depending on world region and prevalence of tobacco use. Often mirroring cancer incidence rates, HPV prevalence and infection natural history varies by gender and anatomic site of infection. Oral HPV infection is rare and significantly differs by gender; yet HPV-related cancer incidence at this site is several-fold higher than at either the anal canal or penile epithelium. HPV seroprevalence is significantly higher among women compared to men, likely explaining the differences in age-specific HPV prevalence and incidence patterns observed by gender. Correspondingly, among heterosexual partners, HPV transmission appears higher from women to men. More research is needed to characterize HPV natural history at each anatomic site where HPV causes cancer in men and women, information that is critical to inform the basic science of HPV natural history and the development of future infection and cancer prevention efforts. PMID:25043222

EUROGIN 2014 roadmap: differences in human papillomavirus infection natural history, transmission and human papillomavirus-related cancer incidence by gender and anatomic site of infection.

PubMed

Giuliano, Anna R; Nyitray, Alan G; Kreimer, Aimée R; Pierce Campbell, Christine M; Goodman, Marc T; Sudenga, Staci L; Monsonego, Joseph; Franceschi, Silvia

2015-06-15

Human papillomaviruses (HPVs) cause cancer at multiple anatomic sites in men and women, including cervical, oropharyngeal, anal, vulvar and vaginal cancers in women and oropharyngeal, anal and penile cancers in men. In this EUROGIN 2014 roadmap, differences in HPV-related cancer and infection burden by gender and anatomic site are reviewed. The proportion of cancers attributable to HPV varies by anatomic site, with nearly 100% of cervical, 88% of anal and <50% of lower genital tract and oropharyngeal cancers attributable to HPV, depending on world region and prevalence of tobacco use. Often, mirroring cancer incidence rates, HPV prevalence and infection natural history varies by gender and anatomic site of infection. Oral HPV infection is rare and significantly differs by gender; yet, HPV-related cancer incidence at this site is several-fold higher than at either the anal canal or the penile epithelium. HPV seroprevalence is significantly higher among women compared to men, likely explaining the differences in age-specific HPV prevalence and incidence patterns observed by gender. Correspondingly, among heterosexual partners, HPV transmission appears higher from women to men. More research is needed to characterize HPV natural history at each anatomic site where HPV causes cancer in men and women, information that is critical to inform the basic science of HPV natural history and the development of future infection and cancer prevention efforts. © 2014 UICC.

The Neurodevelopmental Basis of Early Childhood Disruptive Behavior: Irritable and Callous Phenotypes as Exemplars.

PubMed

Wakschlag, Lauren S; Perlman, Susan B; Blair, R James; Leibenluft, Ellen; Briggs-Gowan, Margaret J; Pine, Daniel S

2018-02-01

The arrival of the Journal's 175th anniversary occurs at a time of recent advances in research, providing an ideal opportunity to present a neurodevelopmental roadmap for understanding, preventing, and treating psychiatric disorders. Such a roadmap is particularly relevant for early-childhood-onset neurodevelopmental conditions, which emerge when experience-dependent neuroplasticity is at its peak. Employing a novel developmental specification approach, this review places recent neurodevelopmental research on early childhood disruptive behavior within the historical context of the Journal. The authors highlight irritability and callous behavior as two core exemplars of early disruptive behavior. Both phenotypes can be reliably differentiated from normative variation as early as the first years of life. Both link to discrete pathophysiology: irritability with disruptions in prefrontal regulation of emotion, and callous behavior with abnormal fear processing. Each phenotype also possesses clinical and predictive utility. Based on a nomologic net of evidence, the authors conclude that early disruptive behavior is neurodevelopmental in nature and should be reclassified as an early-childhood-onset neurodevelopmental condition in DSM-5. Rapid translation from neurodevelopmental discovery to clinical application has transformative potential for psychiatric approaches of the millennium. [AJP at 175: Remembering Our Past As We Envision Our Future November 1938: Electroencephalographic Analyses of Behavior Problem Children Herbert Jasper and colleagues found that brain abnormalities revealed by EEG are a potential causal factor in childhood behavioral disorders. (Am J Psychiatry 1938; 95:641-658 )].

Positive Emotion Regulation and Psychopathology: A Transdiagnostic Cultural Neuroscience Approach

PubMed Central

Hechtman, Lisa A.; Raila, Hannah; Chiao, Joan Y.; Gruber, June

2013-01-01

There is burgeoning interest in the study of positive emotion regulation and psychopathology. Given the significant public health costs and the tremendous variance in national prevalence rates associated with many disorders of positive emotion, it is critical to reach an understanding of how cultural factors, along with biological factors, mutually influence positive emotion regulation. Progress in this domain has been relatively unexplored, however, underscoring the need for an integrative review and empirical roadmap for investigating the cultural neuroscientific contributions to positive emotion disturbance for both affective and clinical science domains. The present paper thus provides a multidisciplinary, cultural neuroscience approach to better understand positive emotion regulation and psychopathology. We conclude with a future roadmap for researchers aimed at harnessing positive emotion and alleviating the burden of mental illness cross-culturally. PMID:24812583

A technology roadmap of smart biosensors from conventional glucose monitoring systems.

PubMed

Shende, Pravin; Sahu, Pratiksha; Gaud, Ram

2017-06-01

The objective of this review article is to focus on technology roadmap of smart biosensors from a conventional glucose monitoring system. The estimation of glucose with commercially available devices involves analysis of blood samples that are obtained by pricking finger or extracting blood from the forearm. Since pain and discomfort are associated with invasive methods, the non-invasive measurement techniques have been investigated. The non-invasive methods show advantages like non-exposure to sharp objects such as needles and syringes, due to which there is an increase in testing frequency, improved control of glucose concentration and absence of pain and biohazard materials. This review study is aimed to describe recent invasive techniques and major noninvasive techniques, viz. biosensors, optical techniques and sensor-embedded contact lenses for glucose estimation.

Use of the RISK21 roadmap and matrix: human health risk assessment of the use of a pyrethroid in bed netting

PubMed Central

Doe, John E.; Lander, Deborah R.; Doerrer, Nancy G.; Heard, Nina; Hines, Ronald N.; Lowit, Anna B.; Pastoor, Timothy; Phillips, Richard D.; Sargent, Dana; Sherman, James H.; Young Tanir, Jennifer; Embry, Michelle R.

2016-01-01

Abstract The HESI-coordinated RISK21 roadmap and matrix are tools that provide a transparent method to compare exposure and toxicity information and assess whether additional refinement is required to obtain the necessary precision level for a decision regarding safety. A case study of the use of a pyrethroid, “pseudomethrin,” in bed netting to control malaria is presented to demonstrate the application of the roadmap and matrix. The evaluation began with a problem formulation step. The first assessment utilized existing information pertaining to the use and the class of chemistry. At each stage of the step-wise approach, the precision of the toxicity and exposure estimates were refined as necessary by obtaining key data which enabled a decision on safety to be made efficiently and with confidence. The evaluation demonstrated the concept of using existing information within the RISK21 matrix to drive the generation of additional data using a value-of-information approach. The use of the matrix highlighted whether exposure or toxicity required further investigation and emphasized the need to address the default uncertainty factor of 100 at the highest tier of the evaluation. It also showed how new methodology such as the use of in vitro studies and assays could be used to answer the specific questions which arise through the use of the matrix. The matrix also serves as a useful means to communicate progress to stakeholders during an assessment of chemical use. PMID:26517449

CFD validation experiments for hypersonic flows

NASA Technical Reports Server (NTRS)

Marvin, Joseph G.

1992-01-01

A roadmap for CFD code validation is introduced. The elements of the roadmap are consistent with air-breathing vehicle design requirements and related to the important flow path components: forebody, inlet, combustor, and nozzle. Building block and benchmark validation experiments are identified along with their test conditions and measurements. Based on an evaluation criteria, recommendations for an initial CFD validation data base are given and gaps identified where future experiments could provide new validation data.

Engineering Effort Needed to Design Spacecraft with Radiation Constraints

NASA Technical Reports Server (NTRS)

Singleterry, Robert C., Jr.

2005-01-01

A roadmap is articulated that describes what is needed to allow designers, to include researchers, management, and engineers, to investigate, design, build, test, and fly spacecraft that meet the mission requirements yet, be as low cost as possible. This roadmap describes seven levels of tool fidelity and application: 1) Mission Speculation, 2) Management Overview, 3) Mission Design, 4) Detailed Design, 5) Simulation and Training, 6) Operations, and 7) Research. The interfaces and output are described in top-level detail along with the transport engines needed, and deficiencies are noted. This roadmap, if implemented, will allow Multidisciplinary Optimization (MDO) ideas to incorporate radiation concerns. Also, as NASA moves towards Simulation Based Acquisition (SBA), these tools will facilitate the appropriate spending of government money. Most of the tools needed to serve these levels do not exist or exist in pieces and need to be integrated to create the tool.

Technology Area Roadmap for In Space Propulsion Technologies

NASA Technical Reports Server (NTRS)

Johnson, Les; Meyer, Mike; Coote, David; Goebel, Dan; Palaszewski, Bryan; White, Sonny

2010-01-01

This slide presentation reviews the technology area (TA) roadmap to develop propulsion technologies that will be used to enable further exploration of the solar system, and beyond. It is hoped that development of the technologies within this TA will result in technical solutions that will improve thrust levels, specific impulse, power, specific mass, volume, system mass, system complexity, operational complexity, commonality with other spacecraft systems, manufacturability and durability. Some of the propulsion technologies that are reviewed include: chemical and non-chemical propulsion, and advanced propulsion (i.e., those with a Technology Readiness level of less than 3). Examples of these advanced technologies include: Beamed Energy, Electric Sail, Fusion, High Energy Density Materials, Antimatter, Advanced Fission and Breakthrough propulsion technologies. Timeframes for development of some of these propulsion technologies are reviewed, and top technical challenges are reviewed. This roadmap describes a portfolio of in-space propulsion technologies that can meet future space science and exploration needs.

A roadmap for bridging basic and applied research in forensic entomology.

PubMed

Tomberlin, J K; Mohr, R; Benbow, M E; Tarone, A M; VanLaerhoven, S

2011-01-01

The National Research Council issued a report in 2009 that heavily criticized the forensic sciences. The report made several recommendations that if addressed would allow the forensic sciences to develop a stronger scientific foundation. We suggest a roadmap for decomposition ecology and forensic entomology hinging on a framework built on basic research concepts in ecology, evolution, and genetics. Unifying both basic and applied research fields under a common umbrella of terminology and structure would facilitate communication in the field and the production of scientific results. It would also help to identify novel research areas leading to a better understanding of principal underpinnings governing ecosystem structure, function, and evolution while increasing the accuracy of and ability to interpret entomological evidence collected from crime scenes. By following the proposed roadmap, a bridge can be built between basic and applied decomposition ecology research, culminating in science that could withstand the rigors of emerging legal and cultural expectations.

Mission Assurance Modeling and Simulation: A Cyber Security Roadmap

NASA Technical Reports Server (NTRS)

Gendron, Gerald; Roberts, David; Poole, Donold; Aquino, Anna

2012-01-01

This paper proposes a cyber security modeling and simulation roadmap to enhance mission assurance governance and establish risk reduction processes within constrained budgets. The term mission assurance stems from risk management work by Carnegie Mellon's Software Engineering Institute in the late 19905. By 2010, the Defense Information Systems Agency revised its cyber strategy and established the Program Executive Officer-Mission Assurance. This highlights a shift from simply protecting data to balancing risk and begins a necessary dialogue to establish a cyber security roadmap. The Military Operations Research Society has recommended a cyber community of practice, recognizing there are too few professionals having both cyber and analytic experience. The authors characterize the limited body of knowledge in this symbiotic relationship. This paper identifies operational and research requirements for mission assurance M&S supporting defense and homeland security. M&S techniques are needed for enterprise oversight of cyber investments, test and evaluation, policy, training, and analysis.

Environmental Control and Life Support (ECLS) Integrated Roadmap Development

NASA Technical Reports Server (NTRS)

Metcalf, Jordan L.; Carrasquillo, Robyn; Bagdigian, Bob; Peterson, Laurie

2011-01-01

This white paper documents a roadmap for development of Environmental Control and Life Support (ECLS) Systems (ECLSS) capabilities required to enable beyond-Low Earth Orbit (LEO) Exploration missions. In many cases, the execution of this Exploration-based roadmap will directly benefit International Space Station (ISS) operational capability by resolving known issues and/or improving overall system reliability. In addition, many of the resulting products will be applicable across multiple Exploration elements such as Multi-Purpose Crew Vehicle (MPCV), Multi-Mission Space Exploration Vehicle (MMSEV), Deep Space Habitat (DSH), and Landers. Within the ECLS community, this white paper will be a unifying tool that will improve coordination of resources, common hardware, and technologies. It will help to align efforts to focus on the highest priority needs that will produce life support systems for future human exploration missions that will simply run in the background, requiring minimal crew interaction.

Comprehensive Smart Grid Planning in a Regulated Utility Environment

NASA Astrophysics Data System (ADS)

Turner, Matthew; Liao, Yuan; Du, Yan

2015-06-01

This paper presents the tools and exercises used during the Kentucky Smart Grid Roadmap Initiative in a collaborative electric grid planning process involving state regulators, public utilities, academic institutions, and private interest groups. The mandate of the initiative was to assess the existing condition of smart grid deployments in Kentucky, to enhance understanding of smart grid concepts by stakeholders, and to develop a roadmap for the deployment of smart grid technologies by the jurisdictional utilities of Kentucky. Through involvement of many important stakeholder groups, the resultant Smart Grid Deployment Roadmap proposes an aggressive yet achievable strategy and timetable designed to promote enhanced availability, security, efficiency, reliability, affordability, sustainability and safety of the electricity supply throughout the state while maintaining Kentucky's nationally competitive electricity rates. The models and methods developed for this exercise can be utilized as a systematic process for the planning of coordinated smart grid deployments.

Systems biology in hepatology: approaches and applications.

PubMed

Mardinoglu, Adil; Boren, Jan; Smith, Ulf; Uhlen, Mathias; Nielsen, Jens

2018-06-01

Detailed insights into the biological functions of the liver and an understanding of its crosstalk with other human tissues and the gut microbiota can be used to develop novel strategies for the prevention and treatment of liver-associated diseases, including fatty liver disease, cirrhosis, hepatocellular carcinoma and type 2 diabetes mellitus. Biological network models, including metabolic, transcriptional regulatory, protein-protein interaction, signalling and co-expression networks, can provide a scaffold for studying the biological pathways operating in the liver in connection with disease development in a systematic manner. Here, we review studies in which biological network models were used to integrate multiomics data to advance our understanding of the pathophysiological responses of complex liver diseases. We also discuss how this mechanistic approach can contribute to the discovery of potential biomarkers and novel drug targets, which might lead to the design of targeted and improved treatment strategies. Finally, we present a roadmap for the successful integration of models of the liver and other human tissues with the gut microbiota to simulate whole-body metabolic functions in health and disease.

Rapid Cost Assessment of Space Mission Concepts through Application of Complexity Indices

NASA Technical Reports Server (NTRS)

Peterson, Craig; Cutts, James; Balint, Tibor; Hall, James B.

2008-01-01

In 2005, the Solar System Exploration Strategic Roadmap Conmrittee (chartered by NASA to develop the roadmap for Solar System Exploration Missions for the coming decades) found itself posed with the difficult problem of sorting through several mission concepts and determining their relative costs. While detailed mission studies are the normal approach to costing, neither the budget nor schedule allotted to the conmrittee could support such studies. Members of the Jet Propulsion Laboratory (JPL) supporting the conmrittee were given the challenge of developing a semi-quantitative approach that could provide the relative costs of these missions, without requiring an in depth study of the missions. In response to this challenge, a rapid cost assessment methodology based on a set of mission cost/complexity indexes was developed. This methodology also underwent two separate validations, one comparing its results when applied to historical missions, and another comparing its estimates against those of veteran space mission managers. Remarkably good agreement was achieved, suggesting that this approach provides an effective early indication of space mission costs.

Stakeholder Engagement Road Map and Peer Review Overview for EPA's Study of the Potential Impacts of Hydraulic Fracturing on Drinking Water Resources

EPA Pesticide Factsheets

This roadmap outlines EPA’s plans to build upon the Agency’s commitment to transparency & stakeholder engagement coordinated during the development of the Hydraulic Fracturing (HF) Study Plan & will help inform the 2014 HF study draft assessment report.

Vitamin D deficiency in critically ill children: A roadmap to interventional research

USDA-ARS?s Scientific Manuscript database

Two studies published this month in Pediatrics provide new and unique information regarding the relationship between vitamin D status and critical illnesses in children admitted to PICUs in the United States and Canada. These two studies, from Boston Children's Hospital and six PICUs in Canada, demo...

Effective methodology to derive strategic decisions from ESA exploration technology roadmaps

NASA Astrophysics Data System (ADS)

Cresto Aleina, Sara; Viola, Nicole; Fusaro, Roberta; Saccoccia, Giorgio

2016-09-01

Top priorities in future international space exploration missions regard the achievement of the necessary maturation of enabling technologies, thereby allowing Europe to play a role commensurate with its industrial, operational and scientific capabilities. As part of the actions derived from this commitment, ESA Technology Roadmaps for Exploration represent a powerful tool to prioritise R&D activities in technologies for space exploration and support the preparation of a consistent procurement plan for space exploration technologies in Europe. The roadmaps illustrate not only the technology procurement (to TRL-8) paths for specific missions envisaged in the present timeframe, but also the achievement for Europe of technological milestones enabling operational capabilities and building blocks, essential for current and future Exploration missions. Coordination of requirements and funding sources among all European stakeholders (ESA, EU, National, and Industry) is one of the objectives of these roadmaps, that show also possible application of the technologies beyond space exploration, both at ESA and outside. The present paper describes the activity that supports the work on-going at ESA on the elaboration and update of these roadmaps and related tools, in order to criticise the followed approach and to suggest methodologies of assessment of the Roadmaps, and to derive strategic decision for the advancement of Space Exploration in Europe. After a review of Technology Areas, Missions/Programmes and related building blocks (architectures) and operational capabilities, technology applicability analyses are presented. The aim is to identify if a specific technology is required, applicable or potentially a demonstrator in the building blocks of the proposed mission concepts. In this way, for each technology it is possible to outline one or more specific plans to increase TRL up to the required level. In practice, this translates into two possible solutions: on the one hand, approved mission concepts will be complemented with the required technologies if the latter can be considered as applicable or demo; on the other, if they are neither applicable nor demo, new missions, i.e. technology demonstrators based on multidisciplinary grouping of key technologies, shall be evaluated, so as to proceed through incremental steps. Finally, techniques to determine priorities in technology procurement are identified, and methodologies to rank the required technologies are proposed. In addition, a tool that estimates the percentage of technologies required for the final destination that are implementable in each intermediate destination of the incremental approach is presented.

Approach to technology prioritization in support of moon initiatives in the framework of ESA exploration technology roadmaps

NASA Astrophysics Data System (ADS)

Aleina, Sara Cresto; Viola, Nicole; Fusaro, Roberta; Saccoccia, Giorgio

2017-10-01

Exploration technology roadmaps have been developed by ESA in the past few years and the latest edition has been released in 2015. Scope of these technology roadmaps, elaborated in consultation with the different ESA stakeholders (e.g. European Industries and Research Entities), is to provide a powerful tool for strategic, programmatic and technical decisions in support of the European role within an International Space Exploration context. In the context of preparation for possible future European Moon exploration initiatives, the technology roadmaps have been used to highlight the role of technology within Missions, Building Blocks and Operational Capabilities of relevance. In particular, as part of reference missions to the Moon that would fit in the time frame 2020 to 2030, ESA has addressed the definition of lunar surface exploration missions in line with its space exploration strategy, with the common mission goals of returning samples from the Moon and Mars and expanding human presence to these destinations in a step-wise approach. The roadmaps for the procurement of technologies required for the first mission elements of the above strategy have been elaborated through their main building blocks, i.e. Visual navigation, Hazard detection and avoidance; Sample acquisition, processing and containment system; Surface mobility elements; Tele-robotic and autonomous control systems; and Storable propulsion modules and equipment. Technology prioritization methodologies have been developed in support of the ESA Exploration Technology Roadmaps, in order to provide logical and quantitative instruments to verify choices of prioritization that can be carried out based on important, but non-quantitative factors. These methodologies, which are thoroughly described in the first part of the paper, proceed through subsequent steps. First, technology prioritization's criteria are selected; then decision trees are developed to highlight all feasible paths of combination of technology prioritization's criteria and to assess the final achievement of each path, i.e. the cost-effectiveness. The risk associated to each path is also evaluated. In the second part of the paper, these prioritization methodologies have been applied to some of the building blocks of relevance for the mission concepts under evaluation at ESA (such as Tele-robotic and autonomous control systems; Storable propulsion modules and equipment) and the results are presented to highlight the approach for an effective TRL increase. Eventually main conclusions are drawn.

Eco-approach and Eco-departure planning study : final report.

DOT National Transportation Integrated Search

2016-01-31

A long term (10 year) research roadmap is proposed to guide the development and potential deployment of Eco-Approach and Departure (Eco A/D) functionality at signalized intersections, with a focus on commercialization of initial system concepts in 5+...

Roadmap to Secure Control Systems in the Water Sector

DTIC Science & Technology

2008-03-01

solutions for ICS security. The purposes of this roadmap are as follows: • Define a consensus-based framework that articulates strategies of owners and...each failure is manageable in itself • Be used as ransomware 400,000 persons, and was estimated by the Center for Disease Control (CDC) to cost a total...and focused efforts. The water sector has developed and will pursue a set of strategic goals articulating these ambitions. These goals will help

Technology Interdependency Roadmaps for Space Operations

NASA Technical Reports Server (NTRS)

Krishen, Kumar

1995-01-01

The requirements for Space Technology are outlined in terms of NASA Strategic Plan. The national emphasis on economic revitalization is described along with the environmental changes needed for the new direction. Space Technology Interdependency (STI) is elaborated in terms of its impact on national priority on science, education, and economy. Some suggested approaches to strengthening STI are outlined. Finally, examples of Technology Roadmaps for Space Operations area are included to illustrate the value of STI for national cohesiveness and economic revitalization.

Design Through Analysis (DTA) roadmap vision.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blacker, Teddy Dean; Adams, Charles R.; Hoffman, Edward L.

2004-10-01

The Design through Analysis Realization Team (DART) will provide analysts with a complete toolset that reduces the time to create, generate, analyze, and manage the data generated in a computational analysis. The toolset will be both easy to learn and easy to use. The DART Roadmap Vision provides for progressive improvements that will reduce the Design through Analysis (DTA) cycle time by 90-percent over a three-year period while improving both the quality and accountability of the analyses.

Report of the 2016-17 Academic Affairs Standing Committee: Entrustable Professional Activities Implementation Roadmap.

PubMed

Pittenger, Amy L; Copeland, Debra A; Lacroix, Matthew M; Masuda, Quamrun N; Mbi, Peter; Medina, Melissa S; Miller, Susan M; Stolte, Scott K; Plaza, Cecilia M

2017-06-01

The purpose of this report is to: 1) Identify linkages across the EPA statements, Center for the Advancement of Pharmacy Education 2013 Educational Outcomes (CAPE 2013) and the Joint Commission of Pharmacy Practitioners' Pharmacist Patient Care Process (PPCP); 2) Provide ways EPA statements can be used to communicate core skills that are part of the entry-level pharmacist identity; 3) Suggest a potential roadmap for AACP members on how to implement EPA statements.

Continuing the International Roadmapping Effort - An Introduction to the Evolution of the ISECG Global Exploration Roadmap

NASA Astrophysics Data System (ADS)

Schlutz, Juergen; Hufenbach, Bernhard; Laurini, Kathy; Spiero, Francois

2016-07-01

Future space exploration goals call for sending humans and robots beyond low Earth orbit and establishing sustained access to destinations such as the Moon, asteroids and Mars. Space agencies participating in the International Space Exploration Coordination Group (ISECG) are discussing an international approach for achieving these goals, documented in ISECG's Global Exploration Roadmap (GER). The GER reference scenario reflects a step-wise evolution of critical capabilities from ISS to missions in the lunar vicinity in preparation for the journey of humans to Mars. As ISECG agencies advance their individual planning, they also advance the mission themes and reference architecture of the GER to consolidate common goals, near-term mission scenarios and initial opportunities for collaboration. In this context, particular focus has been given to the Better understanding and further refinement of cislunar infrastructure and potential lunar transportation architecture Interaction with international science communities to identify and articulate the scientific opportunities of the near-term exploration mission themes Coordination and consolidation of interest in lunar polar volatiles prospecting and potential for in-situ resource utilisation Identification and articulation of the benefits from exploration and the technology transfer activities The paper discusses the ongoing roadmapping activity of the ISECG agencies. It provides an insight into the status of the above activities and an outlook towards the evolution of the GER that is currently foreseen in the 2017 timeframe.

The APIC research agenda: results from a national survey.

PubMed

Wright, Marc-Oliver; Carter, Eileen; Pogorzelska, Monika; Murphy, Cathryn; Hanchett, Marilyn; Stone, Patricia W

2012-05-01

Research is an integral component of the Association for Professionals in Infection Control and Epidemiology (APIC) Strategic Plan 2020. As the role of the infection preventionist (IP) has evolved toward consumers and implementers of research, it becomes increasingly necessary to assess which topics require further evidence and how best APIC can assist IPs. In 2010, APIC determined that the research priorities first described in 2000 needed to be re-evaluated. A 33-question Web-based survey was developed and distributed via e-mail to APIC members in March 2011. The survey contained sections inquiring about respondents' demographics, familiarity with implementation science, and infection prevention research priorities. Priorities identified by a Delphi study 10 years ago were re-ranked, and open-ended items were used to identify new research priorities and understand how APIC could best serve its members in relation to research. Seven hundred one members responded. Behavioral management science, surveillance standards, and infection prevention resource optimization were the highest ranked priorities and relatively unchanged from 2000. Proposed additional research topics focused on achieving standardization in infection prevention practices and program resource allocation. The majority of respondents described APIC's role in the field of research as a disseminator of low-cost, highly accessible education to its members. This report should be used as a roadmap for APIC leadership as it provides suggestions on how APIC may best direct the association's research program. The major research priorities described and ranked in 2000 continue to challenge IPs. APIC can best serve its members by disseminating research findings in a cost-effective and easily accessed manner. Recurrent assessments of research priorities can help guide researchers and policy makers and help determine which topics will best support successful infection prevention processes and outcomes. Published by Mosby, Inc.

The European Research Infrastructure for Heritage Science (erihs)

NASA Astrophysics Data System (ADS)

Striova, J.; Pezzati, L.

2017-08-01

The European Research Infrastructure for Heritage Science (E-RIHS) entered the European strategic roadmap for research infrastructures (ESFRI Roadmap [1]) in 2016, as one of its six new projects. E-RIHS supports research on heritage interpretation, preservation, documentation and management. Both cultural and natural heritage are addressed: collections, artworks, buildings, monuments and archaeological sites. E-RIHS aims to become a distributed research infrastructure with a multi-level star-structure: facilities from single Countries will be organized in national nodes, coordinated by National Hubs. The E-RIHS Central Hub will provide the unique access point to all E-RIHS services through coordination of National Hubs. E-RIHS activities already started in some of its national nodes. In Italy the access to some E-RIHS services started in 2015. A case study concerning the diagnostic of a hypogea cave is presented.

A Strategy for Origins of Life Research.

PubMed

Scharf, Caleb; Virgo, Nathaniel; Cleaves, H James; Aono, Masashi; Aubert-Kato, Nathanael; Aydinoglu, Arsev; Barahona, Ana; Barge, Laura M; Benner, Steven A; Biehl, Martin; Brasser, Ramon; Butch, Christopher J; Chandru, Kuhan; Cronin, Leroy; Danielache, Sebastian; Fischer, Jakob; Hernlund, John; Hut, Piet; Ikegami, Takashi; Kimura, Jun; Kobayashi, Kensei; Mariscal, Carlos; McGlynn, Shawn; Menard, Brice; Packard, Norman; Pascal, Robert; Pereto, Juli; Rajamani, Sudha; Sinapayen, Lana; Smith, Eric; Switzer, Christopher; Takai, Ken; Tian, Feng; Ueno, Yuichiro; Voytek, Mary; Witkowski, Olaf; Yabuta, Hikaru

2015-12-01

Contents 1. Introduction 1.1. A workshop and this document 1.2. Framing origins of life science 1.2.1. What do we mean by the origins of life (OoL)? 1.2.2. Defining life 1.2.3. How should we characterize approaches to OoL science? 1.2.4. One path to life or many? 2. A Strategy for Origins of Life Research 2.1. Outcomes-key questions and investigations 2.1.1. Domain 1: Theory 2.1.2. Domain 2: Practice 2.1.3. Domain 3: Process 2.1.4. Domain 4: Future studies 2.2. EON Roadmap 2.3. Relationship to NASA Astrobiology Roadmap and Strategy documents and the European AstRoMap   Appendix I   Appendix II   Supplementary Materials  References.

NASA Technology Area 07: Human Exploration Destination Systems Roadmap

NASA Technical Reports Server (NTRS)

Kennedy, Kriss J.; Alexander, Leslie; Landis, Rob; Linne, Diane; Mclemore, Carole; Santiago-Maldonado, Edgardo; Brown, David L.

2011-01-01

This paper gives an overview of the National Aeronautics and Space Administration (NASA) Office of Chief Technologist (OCT) led Space Technology Roadmap definition efforts. This paper will given an executive summary of the technology area 07 (TA07) Human Exploration Destination Systems (HEDS). These are draft roadmaps being reviewed and updated by the National Research Council. Deep-space human exploration missions will require many game changing technologies to enable safe missions, become more independent, and enable intelligent autonomous operations and take advantage of the local resources to become self-sufficient thereby meeting the goal of sustained human presence in space. Taking advantage of in-situ resources enhances and enables revolutionary robotic and human missions beyond the traditional mission architectures and launch vehicle capabilities. Mobility systems will include in-space flying, surface roving, and Extra-vehicular Activity/Extravehicular Robotics (EVA/EVR) mobility. These push missions will take advantage of sustainability and supportability technologies that will allow mission independence to conduct human mission operations either on or near the Earth, in deep space, in the vicinity of Mars, or on the Martian surface while opening up commercialization opportunities in low Earth orbit (LEO) for research, industrial development, academia, and entertainment space industries. The Human Exploration Destination Systems (HEDS) Technology Area (TA) 7 Team has been chartered by the Office of the Chief Technologist (OCT) to strategically roadmap technology investments that will enable sustained human exploration and support NASA s missions and goals for at least the next 25 years. HEDS technologies will enable a sustained human presence for exploring destinations such as remote sites on Earth and beyond including, but not limited to, LaGrange points, low Earth orbit (LEO), high Earth orbit (HEO), geosynchronous orbit (GEO), the Moon, near-Earth objects (NEOs), which > 95% are asteroidal bodies, Phobos, Deimos, Mars, and beyond. The HEDS technology roadmap will strategically guide NASA and other U.S. Government agency technology investments that will result in capabilities enabling human exploration missions to diverse destinations generating high returns on investments.

[Initial experience of percutaneous coronary intervention guided by computed tomography coronary angiography derived roadmap and magnetic navigation system].

PubMed

Zhang, Qiu; Kong, De-yu; Li, Chun-jian; Chen, Bo; Jia, En-zhi; Chen, Lei-Lei; Jia, Qing-zhe; Dai, Zhen-hua; Zhu, Tian-tian; Chen, Jun; Liu, Jie; Zhu, Tie-bing; Yang, Zhi-jian; Cao, Ke-jiang

2013-02-01

To evaluate the feasibility, efficacy and safety of the percutaneous coronary intervention (PCI)guided by computed tomography (CT) coronary angiography derived roadmap and magnetic navigation system (MNS). During June 2011 and May 2012, thirty consecutive patients receiving elective PCI were enrolled, coronary artery disease was primarily diagnosed by dual-source CT coronary angiography (DSCT-CA) at outpatient clinic and successively proved by coronary artery angiography in the hospital. Target vessels from pre-procedure DSCT-CA were transferred to the magnetic navigation system, and consequently edited, reconstructed, and projected onto the live fluoroscopic screen as roadmap. Parameters including characters of the target lesions, time, contrast volume, radiation dosage for guidewire crossing, and complications of the procedure were recorded. Thirty patients with 36 lesions were recruited and intervened by PCI. Among the target lesions, sixteen were classified as type A, 11 as type B1, 8 as type B2, 1 as type C. The average length of the target lesions was (22.0 ± 9.8) mm, and the average stenosis of the target lesions was (81.3 ± 10.3)%. Under the guidance of CT roadmap and MNS, 36 target lesions were crossed by the magnetic guidewires, with a lesion crossing ratio of 100%. The time of placement of the magnetic guidewires was 92.5 (56.6 - 131.3) seconds. The contrast volume and the radiation dosage for guidewire placement were 0.0 (0.0 - 3.0) ml and 235.0 (123.5 - 395.1) µGym(2)/36.5 (21.3 - 67.8) mGy, respectively. Guidewires were successfully placed in 21 (58.3%) lesions without contrast agent. All enrolled vessels were successfully treated, and there were no MNS associated complications. It is feasible, effective and safe to initiate PCI under the guidance of CT derived roadmap and MNS. This method might be helpful for the guidewire placement in the treatment of total occlusions.

Graphical Visualization of Human Exploration Capabilities

NASA Technical Reports Server (NTRS)

Rodgers, Erica M.; Williams-Byrd, Julie; Arney, Dale C.; Simon, Matthew A.; Williams, Phillip A.; Barsoum, Christopher; Cowan, Tyler; Larman, Kevin T.; Hay, Jason; Burg, Alex

2016-01-01

NASA's pioneering space strategy will require advanced capabilities to expand the boundaries of human exploration on the Journey to Mars (J2M). The Evolvable Mars Campaign (EMC) architecture serves as a framework to identify critical capabilities that need to be developed and tested in order to enable a range of human exploration destinations and missions. Agency-wide System Maturation Teams (SMT) are responsible for the maturation of these critical exploration capabilities and help formulate, guide and resolve performance gaps associated with the EMC-identified capabilities. Systems Capability Organization Reporting Engine boards (SCOREboards) were developed to integrate the SMT data sets into cohesive human exploration capability stories that can be used to promote dialog and communicate NASA's exploration investments. Each SCOREboard provides a graphical visualization of SMT capability development needs that enable exploration missions, and presents a comprehensive overview of data that outlines a roadmap of system maturation needs critical for the J2M. SCOREboards are generated by a computer program that extracts data from a main repository, sorts the data based on a tiered data reduction structure, and then plots the data according to specified user inputs. The ability to sort and plot varying data categories provides the flexibility to present specific SCOREboard capability roadmaps based on customer requests. This paper presents the development of the SCOREboard computer program and shows multiple complementary, yet different datasets through a unified format designed to facilitate comparison between datasets. Example SCOREboard capability roadmaps are presented followed by a discussion of how the roadmaps are used to: 1) communicate capability developments and readiness of systems for future missions, and 2) influence the definition of NASA's human exploration investment portfolio through capability-driven processes. The paper concludes with a description of planned future work to modify the computer program to include additional data and of alternate capability roadmap formats currently under consideration.

National Aeronautics and Space Administration (NASA) Environmental Control and Life Support (ECLS) Capability Roadmap Development for Exploration

NASA Technical Reports Server (NTRS)

Bagdigian, Robert M.; Carrasquillo, Robyn L.; Metcalf, Jordan; Peterson, Laurie

2012-01-01

NASA is considering a number of future human space exploration mission concepts. Although detailed requirements and vehicle architectures remain mostly undefined, near-term technology investment decisions need to be guided by the anticipated capabilities needed to enable or enhance the mission concepts. This paper describes a roadmap that NASA has formulated to guide the development of Environmental Control and Life Support Systems (ECLSS) capabilities required to enhance the long-term operation of the International Space Station (ISS) and enable beyond-Low Earth Orbit (LEO) human exploration missions. Three generic mission types were defined to serve as a basis for developing a prioritized list of needed capabilities and technologies. Those are 1) a short duration micro gravity mission; 2) a long duration transit microgravity mission; and 3) a long duration surface exploration mission. To organize the effort, ECLSS was categorized into three major functional groups (atmosphere, water, and solid waste management) with each broken down into sub-functions. The ability of existing, flight-proven state-of-the-art (SOA) technologies to meet the functional needs of each of the three mission types was then assessed. When SOA capabilities fell short of meeting the needs, those "gaps" were prioritized in terms of whether or not the corresponding capabilities enable or enhance each of the mission types. The resulting list of enabling and enhancing capability gaps can be used to guide future ECLSS development. A strategy to fulfill those needs over time was then developed in the form of a roadmap. Through execution of this roadmap, the hardware and technologies needed to enable and enhance exploration may be developed in a manner that synergistically benefits the ISS operational capability, supports Multi-Purpose Crew Vehicle (MPCV) development, and sustains long-term technology investments for longer duration missions. This paper summarizes NASA s ECLSS capability roadmap development process, findings, and recommendation

VERAM - Vision and Roadmap for European Raw Materials

NASA Astrophysics Data System (ADS)

Baumgarten, Wibke; Vashev, Boris

2017-04-01

The overall objective of VERAM project is to produce a Vision and Roadmap for European Raw Materials in 2050 based on raw materials research and innovation (R&I) coordination. Two leading European Technology Platforms (ETPs): ETP SMR (Sustainable Minerals Resources) and FTP (Forest Technology Platform) are joining forces to develop a common vison and roadmap with the support of ECTP (European Construction Technology Platform), represented by UNIVPM, SusChem (ETP for Sustainable Chemistry), represented by Cefic, EuMaT (Advanced Materials ETP), represented by VITO, ERAMIN 2, represented by Research Centre JUELICH and WoodWisdom Network Plus represented by the Agency for Renewable Resources (FNR). This partnership provides VERAM with expertise from downstream applications and additional knowledge on non-biotic and biotic raw materials. The project encourages capacity building as well as transfer of knowledge. It expects to provide an innovation reference point for the European Institute of Innovation & Technology (EIT) Raw Materials (formerly the KIC Raw MatTERS), to coordinate the network involved in the European Innovation Partnership (EIP) on Raw Materials Commitments and relevant proposals funded under Horizon 2020. It provides a platform for identifying gaps and complementarities and enables their bridging. VERAM will be able to advise the European Commission and Member States on future research needs and policies to stimulate innovation and assist in overcoming fragmentation in the implementing the EIP Raw Materials Strategic Implementation Plan. VERAM looks for mutually beneficial information exchange, encourages cross-fertilization between actions undertaken by different raw material industries, and expects to accelerate exploitation of breakthrough innovations. One of the main outcomes of the project is the presentation of a common long term 2050 Vision and Roadmap for relevant raw materials including metals, industrial minerals and aggregates and wood. The Vision and Roadmap have the objective of highlighting the path to achieving the European Commission's ambitious target of 80% reduction in CO2 emissions by 2050.

Technology Assessment and Roadmap for the Emergency Radiation Dose Assessment Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Turteltaub, K W; Hartman-Siantar, C; Easterly, C

2005-10-03

A Joint Interagency Working Group (JIWG) under the auspices of the Department of Homeland Security Office of Research and Development conducted a technology assessment of emergency radiological dose assessment capabilities as part of the overall need for rapid emergency medical response in the event of a radiological terrorist event in the United States. The goal of the evaluation is to identify gaps and recommend general research and development needs to better prepare the Country for mitigating the effects of such an event. Given the capabilities and roles for responding to a radiological event extend across many agencies, a consensus ofmore » gaps and suggested development plans was a major goal of this evaluation and road-mapping effort. The working group consisted of experts representing the Departments of Homeland Security, Health and Human Services (Centers for Disease Control and the National Institutes of Health), Food and Drug Administration, Department of Defense and the Department of Energy's National Laboratories (see appendix A for participants). The specific goals of this Technology Assessment and Roadmap were to: (1) Describe the general context for deployment of emergency radiation dose assessment tools following terrorist use of a radiological or nuclear device; (2) Assess current and emerging dose assessment technologies; and (3) Put forward a consensus high-level technology roadmap for interagency research and development in this area. This report provides a summary of the consensus of needs, gaps and recommendations for a research program in the area of radiation dosimetry for early response, followed by a summary of the technologies available and on the near-term horizon. We then present a roadmap for a research program to bring present and emerging near-term technologies to bear on the gaps in radiation dose assessment and triage. Finally we present detailed supporting discussion on the nature of the threats we considered, the status of technology today, promising emerging technologies and references for further reading.« less

Roadmap on optical energy conversion

DOE PAGES

Boriskina, Svetlana V.; Green, Martin A.; Catchpole, Kylie; ...

2016-06-24

For decades, progress in the field of optical (including solar) energy conversion was dominated by advances in the conventional concentrating optics and materials design. In recent years, however, conceptual and technological breakthroughs in the fields of nanophotonics and plasmonics combined with a better understanding of the thermodynamics of the photon energy-conversion processes reshaped the landscape of energy-conversion schemes and devices. Nanostructured devices and materials that make use of size quantization effects to manipulate photon density of states offer a way to overcome the conventional light absorption limits. Novel optical spectrum splitting and photon-recycling schemes reduce the entropy production in themore » optical energy-conversion platforms and boost their efficiencies. Optical design concepts are rapidly expanding into the infrared energy band, offering new approaches to harvest waste heat, to reduce the thermal emission losses, and to achieve noncontact radiative cooling of solar cells as well as of optical and electronic circuitries. Light-matter interaction enabled by nanophotonics and plasmonics underlie the performance of the third- and fourth-generation energy-conversion devices, including up- and down-conversion of photon energy, near-field radiative energy transfer, and hot electron generation and harvesting. Finally, the increased market penetration of alternative solar energy-conversion technologies amplifies the role of cost-driven and environmental considerations. This roadmap on optical energy conversion provides a snapshot of the state of the art in optical energy conversion, remaining challenges, and most promising approaches to address these challenges. Leading experts authored 19 focused short sections of the roadmap where they share their vision on a specific aspect of this burgeoning research field. The roadmap opens up with a tutorial section, which introduces major concepts and terminology. As a result, it is our hope that the roadmap will serve as an important resource for the scientific community, new generations of researchers, funding agencies, industry experts, and investors.« less

Development and application of a framework to assess community nutritionists' use of environmental strategies to prevent obesity.

PubMed

Lu, Angela H; Dickin, Katherine; Dollahite, Jamie

2014-01-01

To develop and apply a framework exploring the extent of involvement in promoting environmental changes to prevent obesity by a group of nutrition educators (NE). Cross-sectional, mixed methods: qualitative interviews informed framework development; survey applied framework to describe NE's involvement in environmental changes. Cooperative Extension in New York State. Interviewees (n = 7) selected to vary in environmental change activities and rural/urban location. Survey response rate was 100% (n = 58). Dimensions and degree of NE's involvement in promoting environmental change. Thematic analysis of qualitative data, triangulated with descriptive analyses of NE's performance of tasks in various settings. NE's promotion of environmental changes was characterized using framework based on settings and tasks, dimensions that emerged from qualitative analysis. NE's actions varied across these dimensions and ranged from low to high intensity of collaboration and leadership for environmental change. Most NE surveyed reported actions limited to providing information and recommendations on healthy eating and physical activity. Few reported intensive engagement in developing, implementing, and evaluating plans to change environments for obesity prevention. Framework identifies the levels of engagement in promoting environmental changes and supports future research and practice of community nutrition professionals by providing a roadmap for assessing their involvement on multiple levels to prevent obesity. Copyright © 2014 Society for Nutrition Education and Behavior. All rights reserved.

A safety roadmap for future plastics and composites intensive vehicles

DOT National Transportation Integrated Search

2007-11-01

This report summarizes the approach, activities, and results of a study to evaluate the potential safety benefits of Plastics and Composites Intensive Vehicles (PCIVs) to enable their deployment by 2020. The main goals were to review and assess the s...

The Long-Term Pavement Performance Program Roadmap: A Strategic Plan

DOT National Transportation Integrated Search

1995-09-01

The goal of the ongoing, 20-year long-term pavement performance (LTPP) studies is to give State and Provincial transportation departments- the owners and customers of the LTPP program-the information and tools they need to build and maintain longer-l...

David Keyser | NREL

Science.gov Websites

. Areas of Expertise Economic impact studies Time series analysis Analysis of labor and demographic data Research Interests Static and dynamic economic impact models Labor data estimation Econometric modeling and 2030: A Strategic Roadmap for American Energy Innovation, Economic Growth, and Competitiveness."

The decline in vitamin research funding: a missed opportunity?

USDA-ARS?s Scientific Manuscript database

Background: The National Nutrition Research Roadmap has called for support of greater collaborative, interdisciplinary research for multiple areas of nutrition research. However, a substantial reduction in federal funding makes responding to these calls challenging. The objective of this study was t...

A global response roadmap to the asteroid impact threat: The NEOShield perspective

NASA Astrophysics Data System (ADS)

Perna, D.; Barucci, M. A.; Drube, L.; Falke, A.; Fulchignoni, M.; Harris, A. W.; Harris, A. W.; Kanuchova, Z.

2015-12-01

Besides being of great scientific interest, near-Earth objects represent a well-founded threat to life on our planet. Nonetheless, up to now there has been no concerted international plan on how to deal with the impact threat, and how to prepare and implement mitigation measures. The NEOShield project is funded by the European Commission to address such issues, to investigate the feasibility of techniques to prevent a potentially catastrophic impact on Earth by an asteroid or a comet, and to develop detailed designs of appropriate space missions to test deflection techniques. In this work we present and discuss the scientific and strategic aspects of the asteroid impact threat, highlighting the necessary steps so as to be ready to react to future hazardous objects.

Acoustical Engineering Controls and Estimated Return on Investment for DoD Selected High Noise Sources: A Roadmap for Future Noise Control in Acquisition

DTIC Science & Technology

2013-04-25

Room 2A534, 1155 Defense Pentagon, Washington, DC 20301-1155 1. DOCUMENTDESCruPTION a . TYPE b. TITLE Acoustical Engineering Controls and Estimated...Return on Investment for DoD Selected Report Hil!h Noise Sources: A Roadmap for Future Noise Control in Acquisition c. PAGE COUNT d. SUBJECT AREA...175 Acoustical Engineering - Noise Control - Acquisition 2. AUTHOR/SPEAKER a . NAME (Last, First, Middlo Initial) b. RANK c. TITLE Erdman, Joy GS-15

Report of the Defense Science Board Task Force on Wideband Radio Frequency Modulation: Dynamic Access to Mobile Information Networks

DTIC Science & Technology

2003-07-01

Centric Architecture Office ( NCAO ) should develop an RF communications/network management technology roadmap. The roadmap should serve two purposes: a...Centric Architecture Office ( NCAO ) chartered with integrating diverse DoD efforts to provide technical alternatives to the current form of radio...American people as a cornerstone of DoD’s leadership of the public trust in this area. The NCAO should be consolidated from ongoing NII, JTRS JPO and DDR

Europe Unveils 20-Year Plan for Brilliant Future in Astronomy

NASA Astrophysics Data System (ADS)

2008-11-01

Astronomy is enjoying a golden age of fundamental, exciting discoveries. Europe is at the forefront, thanks to 50 years of progress in cooperation. To remain ahead over the next two to three decades, Europe must prioritise and coordinate the investment of its financial and human resources even more closely. The ASTRONET network, backed by the entire European scientific community, supported by the European Commission, and coordinated by the CNRS, today presents its Roadmap for a brilliant future for European astronomy. ESO's European Extremely Large Telescope is ranked as one of two top-priority large ground-based projects. Astronet and the E-ELT ESO PR Photo 43a/08 The E-ELT Europe is a leader in astronomy today, with the world's most successful optical observatory, ESO's Very Large Telescope, and cutting-edge facilities in radio astronomy and in space. In an unprecedented effort demonstrating the potential of European scientific cooperation, all of European astronomy is now joining forces to define the scientific challenges for the future and construct a common plan to address them in a cost-effective manner. In 2007, a top-level Science Vision was prepared to assess the most burning scientific questions over the next quarter century, ranging from dark energy to life on other planets. European astronomy now presents its Infrastructure Roadmap, a comprehensive 20-year plan to coordinate national and community investments to meet these challenges in a cost-effective manner. The Roadmap not only prioritises the necessary new frontline research facilities from radio telescopes to planetary probes, in space and on the ground, but also considers such key issues as existing facilities, human resources, ICT infrastructure, education and outreach, and cost -- of operations as well as construction. This bold new initiative -- ASTRONET -- was created by the major European funding agencies with support from the European Commission and is coordinated by the National Institute for Earth Sciences and Astronomy (INSU) of the CNRS. To build consensus on priorities in a very diverse community, the Science Vision and Roadmap were developed in an open process involving intensive interaction with the community through large open meetings and feedback via e-mail and the web. The result is a plan now backed by astronomers in 28 Member and Associated States of the EU, with over 500 million inhabitants. Over 60 selected experts from across Europe contributed to the construction of the ASTRONET Roadmap, ensuring that European astronomy has the tools to compete successfully in answering the challenges of the Science Vision. They identified and prioritised a set of new facilities to observe the Universe from radio waves to gamma rays, to open up new ways of probing the cosmos, such as gravitational waves, and to advance in the exploration of our Solar System. In the process, they considered all the elements needed by a successful scientific enterprise, from global-scale cooperation on the largest mega-project to the need for training and recruiting skilled young scientists and engineers. One of two top-priority large ground-based projects is ESO's European Extremely Large Telescope. Its 42-metre diameter mirror will make the E-ELT the largest optical/near-infrared telescope in the world -- "the biggest eye on the sky". The science to be done with the E-ELT is extremely exciting and includes studies of exoplanets and discs, galaxy formation and dark energy. ESO Director General Tim de Zeeuw says: "The top ranking of the E-ELT in the Roadmap is a strong endorsement from the European astronomical community. This flagship project will indisputably raise the European scientific, technological and industrial profile". Among other recommendations, the Roadmap considers how to maximise the future scientific impact of existing facilities in a cost-effective manner. It also identifies a need for better access to state-of-the art computing and laboratory facilities, and for a stronger involvement of European high-tech industry in the development of future facilities. Moreover, success depends critically upon an adequate supply of qualified scientists, and of engineers in fields ranging from IT to optics. Finally, the Roadmap proposes a series of measures to enhance the public understanding of astronomy as a means to boost recruitment in science and technology in schools and universities across Europe. Europe currently spends approximately €2 billion a year on astronomy in the broadest sense. Implementing the ASTRONET Roadmap will require a funding increase of around 20% -- less than €1 per year per European citizen. Global cooperation will be needed -- and is being planned -- for several of the largest projects.

Drug Hypersensitivity: Pharmacogenetics and Clinical Syndromes

PubMed Central

Phillips, Elizabeth J.; Chung, Wen-Hung; Mockenhaupt, Maja; Roujeau, Jean-Claude; Mallal, Simon A.

2011-01-01

Severe cutaneous adverse reactions (SCARs) include syndromes such as drug reaction, eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS) and Stevens-Johnson Syndrome/Toxic epidermal necrolysis (SJS/TEN). An important advance has been the discovery of associations between HLA alleles and many of these syndromes including abacavir hypersensitivity reaction, allopurinol DRESS/DIHS and SJS/TEN and SJS/TEN associated with aromatic amine anticonvulsants. These HLA associations have created the promise for prevention through screening and have additionally shed further light on the immunopathogenesis of SCARs. The roll-out of HLA-B*5701 into routine clinical practice as a genetic screening test to prevent abacavir hypersensitivity provides a translational roadmap for other drugs. Numerous hurdles exist in the widespread translation of several other drugs such as carbamazepine where the positive predictive value of HLA-B*1502 is low and the negative predictive value of HLA-B*1502 for SJS/TEN may not be 100% in all ethnic groups. International collaborative consortia have been formed with the goal of developing phenotype standardization and undertaking HLA and genome-wide analyses in diverse populations with these syndromes. PMID:21354501

What’s God got to do with it? Engaging African American faith-based institutions in HIV prevention

PubMed Central

Nunn, Amy; Cornwall, Alexandra; Thomas, Gladys; Waller, Pastor Alyn; Friend, Rafiyq; Broadnax, Pastor Jay; Flanigan, Timothy

2013-01-01

African Americans are disproportionately infected and affected by HIV/AIDS. Although faith-based institutions play critical leadership roles in the African American community, the faith-based response to HIV/AIDS has historically been lacking. We explore recent successful strategies of a citywide HIV/AIDS awareness and testing campaign developed in partnership with 40 African American faith-based institutions in Philadelphia, Pennsylvania, a city with some of the United State’s highest HIV infection rates. Drawing on important lessons from the campaign and subsequent efforts to sustain the campaign’s momentum with a citywide HIV testing, treatment and awareness program, we provide a roadmap for engaging African American faith communities in HIV prevention that include partnering with faith leaders; engaging the media to raise awareness, destigmatising HIV/AIDS and encouraging HIV testing; and conducting educational and HIV testing events at houses of worship. African American faith based institutions have a critical role to play in raising awareness about the HIV/AIDS epidemic and for reducing racial disparities in HIV infection. PMID:23379422

Designing and Evaluating Interventions to Halt the Transmission of Tuberculosis.

PubMed

Dowdy, David W; Grant, Alison D; Dheda, Keertan; Nardell, Edward; Fielding, Katherine; Moore, David A J

2017-11-03

To reduce the incidence of tuberculosis, it is insufficient to simply understand the dynamics of tuberculosis transmission. Rather, we must design and rigorously evaluate interventions to halt transmission, prioritizing those interventions most likely to achieve population-level impact. Synergy in reducing tuberculosis transmission may be attainable by combining interventions that shrink the reservoir of latent Mycobacterium tuberculosis infection (preventive therapy), shorten the time between disease onset and treatment initiation (case finding and diagnosis), and prevent transmission in key settings, such as the built environment (infection control). In evaluating efficacy and estimating population-level impact, cluster-randomized trials and mechanistic models play particularly prominent roles. Historical and contemporary evidence suggests that effective public health interventions can halt tuberculosis transmission, but an evidence-based approach based on knowledge of local epidemiology is necessary for success. We provide a roadmap for designing, evaluating, and modeling interventions to interrupt the process of transmission that fuels a diverse array of tuberculosis epidemics worldwide. © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America.

Developmental Systems Toxicology: computer simulation in a ‘Virtual Embryo’ prototype (SEURAT-1 Progress Meeting)

EPA Science Inventory

Evaluating and assessing impacts to development is an Agency priority (EPA’s Children’s Environmental Health Research Roadmap); however, the quantity of chemicals needing assessment and challenges of species extrapolation require alternative approaches to traditional animal studi...

Light Water Reactor Sustainability (LWRS) Program – Non-Destructive Evaluation (NDE) R&D Roadmap for Determining Remaining Useful Life of Aging Cables in Nuclear Power Plants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simmons, Kevin L.; Ramuhalli, Pradeep; Brenchley, David L.

2012-09-14

The purpose of the non-destructive evaluation (NDE) R&D Roadmap for Cables is to support the Materials Aging and Degradation (MAaD) R&D pathway. The focus of the workshop was to identify the technical gaps in detecting aging cables and predicting their remaining life expectancy. The workshop was held in Knoxville, Tennessee, on July 30, 2012, at Analysis and Measurement Services Corporation (AMS) headquarters. The workshop was attended by 30 experts in materials, electrical engineering, U.S. Nuclear Regulatory Commission (NRC), U.S. Department of Energy (DOE) National Laboratories (Oak Ridge National Laboratory, Pacific Northwest National Laboratory, Argonne National Laboratory, and Idaho National Engineeringmore » Laboratory), NDE instrumentation development, universities, commercial NDE services and cable manufacturers, and Electric Power Research Institute (EPRI). The motivation for the R&D roadmap comes from the need to address the aging management of in-containment cables at nuclear power plants (NPPs).« less

Light Water Reactor Sustainability (LWRS) Program – Non-Destructive Evaluation (NDE) R&D Roadmap for Determining Remaining Useful Life of Aging Cables in Nuclear Power Plants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simmons, K.L.; Ramuhali, P.; Brenchley, D.L.

2012-09-01

Executive Summary [partial] The purpose of the non-destructive evaluation (NDE) R&D Roadmap for Cables is to support the Materials Aging and Degradation (MAaD) R&D pathway. A workshop was held to gather subject matter experts to develop the NDE R&D Roadmap for Cables. The focus of the workshop was to identify the technical gaps in detecting aging cables and predicting their remaining life expectancy. The workshop was held in Knoxville, Tennessee, on July 30, 2012, at Analysis and Measurement Services Corporation (AMS) headquarters. The workshop was attended by 30 experts in materials, electrical engineering, and NDE instrumentation development from the U.S.more » Nuclear Regulatory Commission (NRC), U.S. Department of Energy (DOE) National Laboratories (Oak Ridge National Laboratory, Pacific Northwest National Laboratory, Argonne National Laboratory, and Idaho National Engineering Laboratory), universities, commercial NDE service vendors and cable manufacturers, and the Electric Power Research Institute (EPRI).« less

A systems engineering approach to AIS accreditation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harris, L.M.; Hunteman, W.J.

1994-04-01

The systems engineering model provides the vehicle for communication between the developer and the customer by presenting system facts and demonstrating the system in an organized form. The same model provides implementors with views of the system`s function and capability. The authors contend that the process of obtaining accreditation for a classified Automated Information System (AIS) adheres to the typical systems engineering model. The accreditation process is modeled as a ``roadmap`` with the customer represented by the Designed Accrediting Authority. The ``roadmap`` model reduces the amount of accreditation knowledge required of an AIS developer and maximizes the effectiveness of participationmore » in the accreditation process by making the understanding of accreditation a natural consequence of applying the model. This paper identifies ten ``destinations`` on the ``road`` to accreditation. The significance of each ``destination`` is explained, as are the potential consequences of its exclusion. The ``roadmap,`` which has been applied to a range of information systems throughout the DOE community, establishes a paradigm for the certification and accreditation of classified AISs.« less

Development Roadmap of an Evolvable and Extensible Multi-Mission Telecom Planning and Analysis Framework

NASA Technical Reports Server (NTRS)

Cheung, Kar-Ming; Tung, Ramona H.; Lee, Charles H.

2003-01-01

In this paper, we describe the development roadmap and discuss the various challenges of an evolvable and extensible multi-mission telecom planning and analysis framework. Our long-term goal is to develop a set of powerful flexible telecommunications analysis tools that can be easily adapted to different missions while maintain the common Deep Space Communication requirements. The ability of re-using the DSN ground models and the common software utilities in our adaptations has contributed significantly to our development efforts measured in terms of consistency, accuracy, and minimal effort redundancy, which can translate into shorter development time and major cost savings for the individual missions. In our roadmap, we will address the design principles, technical achievements and the associated challenges for following telecom analysis tools (i) Telecom Forecaster Predictor - TFP (ii) Unified Telecom Predictor - UTP (iii) Generalized Telecom Predictor - GTP (iv) Generic TFP (v) Web-based TFP (vi) Application Program Interface - API (vii) Mars Relay Network Planning Tool - MRNPT.

Beyond Einstein

NASA Astrophysics Data System (ADS)

Hertz, P.

2003-03-01

The Structure and Evolution of the Universe (SEU) theme within NASA's Office of Space Science seeks to explore and understand the dynamic transformations of energy in the Universe - the entire web of biological and physical interactions that determine the evolution of our cosmic habitat. This search for understanding will enrich the human spirit and inspire a new generation of explorers, scientists, and engineers. To that end, NASA's strategic planning process has generated a new Roadmap to enable those goals. Called "Beyond Einstein", this Roadmap identifies three science objectives for the SEU theme: (1) Find out what powered the Big Bang; (2) Observe how black holes manipulate space, time, and matter; and (3) Identify the mysterious dark energy pullingthe Universe apart. These objectives can be realized through a combination of large observatories (Constellation-X, LISA), moderate sized, PI-led missions (the Einstein Probes), and a contuinuing program of technology development, research and analysis, and education/public outreach. In this presentation, NASA's proposed Beyond Einstein Program will be described. The full Roadmap is available at http://universe.nasa.gov/.

U.S. Department of Energy Office of Nuclear Technology Research and Eevelopment ((NTRD) comprehensive summary of QA assessments for FY17

DOE Office of Scientific and Technical Information (OSTI.GOV)

Trost, Alan L.

The U.S. Department of Energy (DOE) Office of Nuclear Energy (NE) has developed a research and development (R&D) roadmap for its research, development, and demonstration (RD&D) activities to ensure nuclear energy remains a compelling and viable energy option for the U.S. The roadmap defines NE RD&D activities and objectives that address the challenges to research, develop and demonstrate options to the current U.S commercial fuel cycle to enable the safe, secure, economic, and sustainable expansion of nuclear energy, while minimizing proliferation and terrorism risks expanding the use of nuclear power. The roadmap enables the development of technologies and other solutionsmore » that can improve the reliability, sustain the safety, and extend the life of current reactors. In addition, it will help to develop improvements in the affordability of the new reactors to enable nuclear energy to help meet the Administration’s energy security and climate change goals.« less

Requirements for Designing Life Support System Architectures for Crewed Exploration Missions Beyond Low-Earth Orbit

NASA Technical Reports Server (NTRS)

Howard, David; Perry,Jay; Sargusingh, Miriam; Toomarian, Nikzad

2016-01-01

NASA's technology development roadmaps provide guidance to focus technological development on areas that enable crewed exploration missions beyond low-Earth orbit. Specifically, the technology area roadmap on human health, life support and habitation systems describes the need for life support system (LSS) technologies that can improve reliability and in-situ maintainability within a minimally-sized package while enabling a high degree of mission autonomy. To address the needs outlined by the guiding technology area roadmap, NASA's Advanced Exploration Systems (AES) Program has commissioned the Life Support Systems (LSS) Project to lead technology development in the areas of water recovery and management, atmosphere revitalization, and environmental monitoring. A notional exploration LSS architecture derived from the International Space has been developed and serves as the developmental basis for these efforts. Functional requirements and key performance parameters that guide the exploration LSS technology development efforts are presented and discussed. Areas where LSS flight operations aboard the ISS afford lessons learned that are relevant to exploration missions are highlighted.

Teacher Quality Roadmap: Improving Policies and Practices in Pittsburgh Public Schools

ERIC Educational Resources Information Center

Gonzalez, Angel; Kumar, Sudipti; Waymack, Nancy

2014-01-01

The Pittsburgh Public Schools study is the 12th district study since the National Council on Teacher Quality (NCTQ) began studying districts in-depth in 2009. The intent of these studies is to give select communities a comprehensive look at what is happening in their local school districts that may be either helping or hurting teacher quality, and…

Integrative Medicine in Preventive Medicine Education

PubMed Central

Jani, Asim A.; Trask, Jennifer; Ali, Ather

2016-01-01

During 2012, the USDHHS’s Health Resources and Services Administration funded 12 accredited preventive medicine residencies to incorporate an evidence-based integrative medicine curriculum into their training programs. It also funded a national coordinating center at the American College of Preventive Medicine, known as the Integrative Medicine in Preventive Medicine Education (IMPriME) Center, to provide technical assistance to the 12 grantees. To help with this task, the IMPriME Center established a multidisciplinary steering committee, versed in integrative medicine, whose primary aim was to develop integrative medicine core competencies for incorporation into preventive medicine graduate medical education training. The competency development process was informed by central integrative medicine definitions and principles, preventive medicine’s dual role in clinical and population-based prevention, and the burgeoning evidence base of integrative medicine. The steering committee considered an interdisciplinary integrative medicine contextual framework guided by several themes related to workforce development and population health. A list of nine competencies, mapped to the six general domains of competence approved by the Accreditation Council of Graduate Medical Education, was operationalized through an iterative exercise with the 12 grantees in a process that included mapping each site’s competency and curriculum products to the core competencies. The competencies, along with central curricular components informed by grantees’ work presented elsewhere in this supplement, are outlined as a roadmap for residency programs aiming to incorporate integrative medicine content into their curricula. This set of competencies adds to the larger efforts of the IMPriME initiative to facilitate and enhance further curriculum development and implementation by not only the current grantees but other stakeholders in graduate medical education around integrative medicine training. PMID:26477897

The Role of Cis-Lunar Space in Future Global Space Exploration

NASA Technical Reports Server (NTRS)

Bobskill, Marianne R.; Lupisella, Mark L.

2012-01-01

Cis-lunar space offers affordable near-term opportunities to help pave the way for future global human exploration of deep space, acting as a bridge between present missions and future deep space missions. While missions in cis-lunar space have value unto themselves, they can also play an important role in enabling and reducing risk for future human missions to the Moon, Near-Earth Asteroids (NEAs), Mars, and other deep space destinations. The Cis-Lunar Destination Team of NASA's Human Spaceflight Architecture Team (HAT) has been analyzing cis-lunar destination activities and developing notional missions (or "destination Design Reference Missions" [DRMs]) for cis-lunar locations to inform roadmap and architecture development, transportation and destination elements definition, operations, and strategic knowledge gaps. The cis-lunar domain is defined as that area of deep space under the gravitational influence of the earth-moon system. This includes a set of earth-centered orbital locations in low earth orbit (LEO), geosynchronous earth orbit (GEO), highly elliptical and high earth orbits (HEO), earth-moon libration or "Lagrange" points (E-ML1 through E-ML5, and in particular, E-ML1 and E-ML2), and low lunar orbit (LLO). To help explore this large possibility space, we developed a set of high level cis-lunar mission concepts in the form of a large mission tree, defined primarily by mission duration, pre-deployment, type of mission, and location. The mission tree has provided an overall analytical context and has helped in developing more detailed design reference missions that are then intended to inform capabilities, operations, and architectures. With the mission tree as context, we will describe two destination DRMs to LEO and GEO, based on present human space exploration architectural considerations, as well as our recent work on defining mission activities that could be conducted with an EML1 or EML2 facility, the latter of which will be an emphasis of this paper, motivated in part by recent interest expressed at the Global Exploration Roadmap Stakeholder meeting. This paper will also explore the links between this HAT Cis-Lunar Destination Team analysis and the recently released ISECG Global Exploration Roadmap and other potential international considerations, such as preventing harmful interference to radio astronomy observations in the shielded zone of the moon.

Count every newborn; a measurement improvement roadmap for coverage data.

PubMed

Moxon, Sarah G; Ruysen, Harriet; Kerber, Kate J; Amouzou, Agbessi; Fournier, Suzanne; Grove, John; Moran, Allisyn C; Vaz, Lara M E; Blencowe, Hannah; Conroy, Niall; Gülmezoglu, A; Vogel, Joshua P; Rawlins, Barbara; Sayed, Rubayet; Hill, Kathleen; Vivio, Donna; Qazi, Shamim A; Sitrin, Deborah; Seale, Anna C; Wall, Steve; Jacobs, Troy; Ruiz Peláez, Juan; Guenther, Tanya; Coffey, Patricia S; Dawson, Penny; Marchant, Tanya; Waiswa, Peter; Deorari, Ashok; Enweronu-Laryea, Christabel; Arifeen, Shams; Lee, Anne C C; Mathai, Matthews; Lawn, Joy E

2015-01-01

The Every Newborn Action Plan (ENAP), launched in 2014, aims to end preventable newborn deaths and stillbirths, with national targets of ≤12 neonatal deaths per 1000 live births and ≤12 stillbirths per 1000 total births by 2030. This requires ambitious improvement of the data on care at birth and of small and sick newborns, particularly to track coverage, quality and equity. In a multistage process, a matrix of 70 indicators were assessed by the Every Newborn steering group. Indicators were graded based on their availability and importance to ENAP, resulting in 10 core and 10 additional indicators. A consultation process was undertaken to assess the status of each ENAP core indicator definition, data availability and measurement feasibility. Coverage indicators for the specific ENAP treatment interventions were assigned task teams and given priority as they were identified as requiring the most technical work. Consultations were held throughout. ENAP published 10 core indicators plus 10 additional indicators. Three core impact indicators (neonatal mortality rate, maternal mortality ratio, stillbirth rate) are well defined, with future efforts needed to focus on improving data quantity and quality. Three core indicators on coverage of care for all mothers and newborns (intrapartum/skilled birth attendance, early postnatal care, essential newborn care) have defined contact points, but gaps exist in measuring content and quality of the interventions. Four core (antenatal corticosteroids, neonatal resuscitation, treatment of serious neonatal infections, kangaroo mother care) and one additional coverage indicator for newborns at risk or with complications (chlorhexidine cord cleansing) lack indicator definitions or data, especially for denominators (population in need). To address these gaps, feasible coverage indicator definitions are presented for validity testing. Measurable process indicators to help monitor health service readiness are also presented. A major measurement gap exists to monitor care of small and sick babies, yet signal functions could be tracked similarly to emergency obstetric care. The ENAP Measurement Improvement Roadmap (2015-2020) outlines tools to be developed (e.g., improved birth and death registration, audit, and minimum perinatal dataset) and actions to test, validate and institutionalise proposed coverage indicators. The roadmap presents a unique opportunity to strengthen routine health information systems, crosslinking these data with civil registration and vital statistics and population-based surveys. Real measurement change requires intentional transfer of leadership to countries with the greatest disease burden and will be achieved by working with centres of excellence and existing networks.

Strategic Plans for the Future of Solar Physics: a community discussion of the NASA Sun-Earth Connection Program Roadmap and the NAS Decadal Survey of Astronomy and Astrophysics (Solar Astronomy section)

NASA Astrophysics Data System (ADS)

Schrijver, K.; Knoelker, M.

1999-05-01

The NASA Sun-Earth Connections Program is currently revising its Roadmap, the long-range plan for science goals, technology development, and missions between 2000 and 2040. From the interior dynamics of the Sun, to the interactions of plasma, fields, and radiation in the photosphere and solar atmosphere, to the heating and structure of the corona, to the acceleration, structure, and evolution of the solar wind, to the interactions of the heliosphere with the interstellar medium, to the processes of solar, stellar, and solar system evolution - progress in each of these domains will help us understand how the Sun impacts our home in space. The Roadmap Committee is seeking to refine and extend the SEC's vision and identify the milestone missions for the future. During this session, an outline of the current draft Roadmap will be presented, and further community involvement will be solicited to ensure the strongest possible concensus on the revised Roadmap. The National Academy of Sciences' Space Science Board has appointed a committee to perform a Decadal Survey of Astronomy and Astrophysics, which is surveying the field of space- and ground-based astronomy and astrophysics, recommending priorities for the most important new initiatives of the decade 2000-2010. The prioritization delivered by the earlier Decadal Surveys has played an important role in guiding the funding agencies in setting their priorities for astronomy and astrophysics. Therefore it will be of crucial importance for solar physics to contribute a strong case for its own set of future projects to be incorpoprated into the survey. The solar physics of the next decade will be characterized by its increasing societal relevance in the context of the National Space Weather Program and related issues, as well as its classical importance as a ``base" for many astrophysical questions. The presentation and subsequent discussion at the Chicago meeting is intended to solicit further community input, to achieve optimal representation for solar physics in the Decadal Survey. The Roadmap Committee and the Decadal Survey's solar panel encourage the whole solar physics community to contact them prior to the meeting. The list of the committee/panel members and their e-mail addresses, as well as related information, can be accessed via their websites at http://www.lmsal.com/sec/ and http://www.nas.edu/bpa/projects/astrosurvey/solar/ , respectively.

A roadmap for the integration of culture into developmental psychopathology.

PubMed

Causadias, José M

2013-11-01

In this paper, I propose a roadmap for the integration of culture in developmental psychopathology. This integration is pressing because culture continues to be somewhat disconnected from theory, research, training, and interventions in developmental psychopathology, thus limiting our understanding of the epigenesis of mental health. I argue that in order to successfully integrate culture into developmental psychopathology, it is crucial to (a) study cultural development, (b) consider both individual-level and social-level cultural processes, (c) examine the interplay between culture and biology, and (d) promote improved and direct cultural assessment. I provide evidence in support of each of these guidelines, present alternative conceptual frameworks, and suggest new lines of research. Hopefully, that these directions will contribute to the emerging field of cultural development and psychopathology, which focuses on the elucidation of the cultural processes that initiate, maintain, or derail trajectories of normal and abnormal behavior.

A roadmap towards personalized immunology.

PubMed

Delhalle, Sylvie; Bode, Sebastian F N; Balling, Rudi; Ollert, Markus; He, Feng Q

2018-01-01

Big data generation and computational processing will enable medicine to evolve from a "one-size-fits-all" approach to precise patient stratification and treatment. Significant achievements using "Omics" data have been made especially in personalized oncology. However, immune cells relative to tumor cells show a much higher degree of complexity in heterogeneity, dynamics, memory-capability, plasticity and "social" interactions. There is still a long way ahead on translating our capability to identify potentially targetable personalized biomarkers into effective personalized therapy in immune-centralized diseases. Here, we discuss the recent advances and successful applications in "Omics" data utilization and network analysis on patients' samples of clinical trials and studies, as well as the major challenges and strategies towards personalized stratification and treatment for infectious or non-communicable inflammatory diseases such as autoimmune diseases or allergies. We provide a roadmap and highlight experimental, clinical, computational analysis, data management, ethical and regulatory issues to accelerate the implementation of personalized immunology.

Towards a 21st century roadmap for biomedical research and ...

EPA Pesticide Factsheets

Decades of costly failures in translating drug candidates from preclinical disease models to human therapeutic use warrant reconsideration of the priority placed on animal models in biomedical research. Following an international workshop attended by experts from academia, government institutions, research funding bodies and the corporate and NGO sectors, this consensus report analyses, as case studies, five disease areas with major unmet needs for new treatments. In view of the scientifically driven transition towards a human pathways-based paradigm in toxicology, a similar paradigm shift appears to be justified in biomedical research. There is a pressing need for an approach that strategically implements advanced, human biology-based models and tools to understand disease pathways at multiple biological scales. We present recommendations to help achieve this. To discover and develop new therapies, we need 21-century roadmaps for biomedical research based on multiscale human disease pathways, and supported by policy and funding strategies that prioritise human relevance.

A Strategy for Origins of Life Research

PubMed Central

Scharf, Caleb; Virgo, Nathaniel; Aono, Masashi; Aubert-Kato, Nathanael; Aydinoglu, Arsev; Barahona, Ana; Barge, Laura M.; Benner, Steven A.; Biehl, Martin; Brasser, Ramon; Butch, Christopher J.; Chandru, Kuhan; Cronin, Leroy; Danielache, Sebastian; Fischer, Jakob; Hernlund, John; Hut, Piet; Ikegami, Takashi; Kimura, Jun; Kobayashi, Kensei; Mariscal, Carlos; McGlynn, Shawn; Menard, Brice; Packard, Norman; Pascal, Robert; Pereto, Juli; Rajamani, Sudha; Sinapayen, Lana; Smith, Eric; Switzer, Christopher; Takai, Ken; Tian, Feng; Ueno, Yuichiro; Voytek, Mary; Witkowski, Olaf; Yabuta, Hikaru

2015-01-01

Contents 1. Introduction 1.1. A workshop and this document 1.2. Framing origins of life science 1.2.1. What do we mean by the origins of life (OoL)? 1.2.2. Defining life 1.2.3. How should we characterize approaches to OoL science? 1.2.4. One path to life or many? 2. A Strategy for Origins of Life Research 2.1. Outcomes—key questions and investigations 2.1.1. Domain 1: Theory 2.1.2. Domain 2: Practice 2.1.3. Domain 3: Process 2.1.4. Domain 4: Future studies 2.2. EON Roadmap 2.3. Relationship to NASA Astrobiology Roadmap and Strategy documents and the European AstRoMap  Appendix I  Appendix II  Supplementary Materials  References PMID:26684503

A roadmap for natural product discovery based on large-scale genomics and metabolomics

USDA-ARS?s Scientific Manuscript database

Actinobacteria encode a wealth of natural product biosynthetic gene clusters, whose systematic study is complicated by numerous repetitive motifs. By combining several metrics we developed a method for global classification of these gene clusters into families (GCFs) and analyzed the biosynthetic ca...

Systematic review of environmental risk factors for Obsessive-Compulsive Disorder: A proposed roadmap from association to causation.

PubMed

Brander, Gustaf; Pérez-Vigil, Ana; Larsson, Henrik; Mataix-Cols, David

2016-06-01

To synthesize the current knowledge on possible environmental risk factors for Obsessive-Compulsive Disorder (OCD). We conducted a systematic review following PRISMA guidelines. The Embase, PubMed and Scopus databases were searched up until October 6, 2015, employing relevant keywords and MeSH terms. 128 studies met inclusion criteria. Potential environmental risk factors for OCD have been identified in the broad areas of perinatal complications, reproductive cycle, and stressful life events. There is limited evidence regarding other potential risk factors, such as parental age, season of birth, socioeconomic status, parental rearing practices, infections, traumatic brain injury, substance use or vitamin deficiency. In general, studies were of limited methodological quality. At present, no environmental risk factors have convincingly been associated with OCD. We propose a roadmap for future studies, consisting of longitudinal, population-based research, employing quasi-experimental family and twin designs to identify risk factors that are not only associated with the disorder but also contribute to its causation either directly or moderating the effect of genes. Copyright © 2016 Elsevier Ltd. All rights reserved.

Autonomous Systems: Issues for Defence Policymakers

DTIC Science & Technology

2015-09-30

Unmanned Surveillance Target Acquisition System, and being co-leader of the multi- research centre Manned-Unmanned Aerial Vehicle Interactions study . He...Assessment Scale’ was derived from research into external autonomy applications (Sheridan, Parasuraman, etc.) and other studies . The scale’s...system. This roadmap covers annexes on the regulatory approach, a strategic research plan, and a study of the societal impact of the challenges of RPAS

Global industry status report and roadmap for high performance displays

NASA Astrophysics Data System (ADS)

Bardsley, J. Norman; Pinnel, M. Robert

2003-09-01

A summary is provided of a comprehensive industry status report and roadmap available from www.usdc.org. Continued improvements in LCD technology are being driven by home entertainment applications, leading to better color and video response. Competing technologies, such as PDP and OLED and electronic paper must either exploit inherent advantages for such applications or focus on other market niches that are not being addressed well by mainline LCD technology. Flexible displays provide an opportunity for innovative technologies and manufacturing methods, but appear to bring no killer applications.

Photovoltaics Innovation Roadmap Request for Information Summary

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

On June 28, 2017, the U.S. Department of Energy’s Solar Energy Technologies Office (SETO) released the Photovoltaics (PV) Innovation Roadmap Request for Information (RFI) for public response and comment. The RFI sought feedback from PV stakeholders, including research and commercial communities, about the most important research and development (R&D) pathways to improve PV cell and module technology to reach the SETO’s SunShot 2030 cost targets of $0.03/W for utility PV installations, $0.04/W for commercial scale installations, and $0.05/W for residential PV installations.

Challenges & Roadmap for Beyond CMOS Computing Simulation.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rodrigues, Arun F.; Frank, Michael P.

Simulating HPC systems is a difficult task and the emergence of “Beyond CMOS” architectures and execution models will increase that difficulty. This document presents a “tutorial” on some of the simulation challenges faced by conventional and non-conventional architectures (Section 1) and goals and requirements for simulating Beyond CMOS systems (Section 2). These provide background for proposed short- and long-term roadmaps for simulation efforts at Sandia (Sections 3 and 4). Additionally, a brief explanation of a proof-of-concept integration of a Beyond CMOS architectural simulator is presented (Section 2.3).

The NIH Roadmap Epigenomics Program data resource

PubMed Central

Chadwick, Lisa Helbling

2012-01-01

The NIH Roadmap Reference Epigenome Mapping Consortium is developing a community resource of genome-wide epigenetic maps in a broad range of human primary cells and tissues. There are large amounts of data already available, and a number of different options for viewing and analyzing the data. This report will describe key features of the websites where users will find data, protocols and analysis tools developed by the consortium, and provide a perspective on how this unique resource will facilitate and inform human disease research, both immediately and in the future. PMID:22690667

The NIH Roadmap Epigenomics Program data resource.

PubMed

Chadwick, Lisa Helbling

2012-06-01

The NIH Roadmap Reference Epigenome Mapping Consortium is developing a community resource of genome-wide epigenetic maps in a broad range of human primary cells and tissues. There are large amounts of data already available, and a number of different options for viewing and analyzing the data. This report will describe key features of the websites where users will find data, protocols and analysis tools developed by the consortium, and provide a perspective on how this unique resource will facilitate and inform human disease research, both immediately and in the future.

LAW ENFORCEMENT TECHNOLOGY ROADMAP: LESSONS TO DATE FROM THE NORTHWEST TECHNOLOGY DESK AND THE NORTHWEST FADE PILOTS

DOE Office of Scientific and Technical Information (OSTI.GOV)

West, Curtis L.; Kreyling, Sean J.

The goal of this report is to provide insight into the information technology needs of law enforcement based on first hand observations as an embedded and active participant over the course of two plus years. This report is intended as a preliminary roadmap for technology and project investment that will benefit the entire law enforcement community nationwide. Some recommendations are immediate and have more of an engineering flavor, while others are longer term and will require research and development to solve.

Feasibility and roadmap analysis for malaria elimination in China.

PubMed

Zhou, Xiao-Nong; Xia, Zhi-Gui; Wang, Ru-Bo; Qian, Ying-Jun; Zhou, Shui-Sen; Utzinger, Jürg; Tanner, Marcel; Kramer, Randall; Yang, Wei-Zhong

2014-01-01

To understand the current status of the malaria control programme at the county level in accordance with the criteria of the World Health Organisation, the gaps and feasibility of malaria elimination at the county and national levels were analysed based on three kinds of indicators: transmission capacity, capacity of the professional team, and the intensity of intervention. Finally, a roadmap for national malaria elimination in the People's Republic of China is proposed based on the results of a feasibility assessment at the national level. Copyright © 2014 Elsevier Ltd. All rights reserved.

Completing Your Qualitative Dissertation: A Roadmap from Beginning to End

ERIC Educational Resources Information Center

Bloomberg, Linda Dale; Volpe, Marie F.

2008-01-01

This book fills an important gap in qualitative research literature by specifically addressing the fast-growing practice of qualitative master's studies and doctoral dissertations in colleges and universities throughout the world. Many students struggle with turning qualitative research projects into a master's thesis or doctoral dissertation…

The Translation of Health Research in Kinesiology

ERIC Educational Resources Information Center

Ainsworth, Barbara E.

2009-01-01

The translation of health research is a process of transforming scientific discoveries arising from laboratory, clinical, or population studies into clinical or population-based applications to improve health by reducing disease incidence, morbidity, and mortality. Initiated by the National Institutes for Health Roadmap Initiative and the U.S.…

Action Research on "Visible Learning" in Science

ERIC Educational Resources Information Center

Paterson, David

2014-01-01

"Visible teaching and learning" is an educational philosophy that makes the processes and endpoints in a classroom highly visible and understandable to all involved. This was translated into a series of lesson "roadmaps" for a group of chemistry students studying rates of reaction and reaction energetics. Their end-of-unit…

Quo Vadis Venomics? A Roadmap to Neglected Venomous Invertebrates

PubMed Central

von Reumont, Bjoern Marcus; Campbell, Lahcen I.; Jenner, Ronald A.

2014-01-01

Venomics research is being revolutionized by the increased use of sensitive -omics techniques to identify venom toxins and their transcripts in both well studied and neglected venomous taxa. The study of neglected venomous taxa is necessary both for understanding the full diversity of venom systems that have evolved in the animal kingdom, and to robustly answer fundamental questions about the biology and evolution of venoms without the distorting effect that can result from the current bias introduced by some heavily studied taxa. In this review we draw the outlines of a roadmap into the diversity of poorly studied and understood venomous and putatively venomous invertebrates, which together represent tens of thousands of unique venoms. The main groups we discuss are crustaceans, flies, centipedes, non-spider and non-scorpion arachnids, annelids, molluscs, platyhelminths, nemerteans, and echinoderms. We review what is known about the morphology of the venom systems in these groups, the composition of their venoms, and the bioactivities of the venoms to provide researchers with an entry into a large and scattered literature. We conclude with a short discussion of some important methodological aspects that have come to light with the recent use of new -omics techniques in the study of venoms. PMID:25533518

Developing Your Evaluation Plans: A Critical Component of Public Health Program Infrastructure.

PubMed

Lavinghouze, S Rene; Snyder, Kimberly

A program's infrastructure is often cited as critical to public health success. The Component Model of Infrastructure (CMI) identifies evaluation as essential under the core component of engaged data. An evaluation plan is a written document that describes how to monitor and evaluate a program, as well as how to use evaluation results for program improvement and decision making. The evaluation plan clarifies how to describe what the program did, how it worked, and why outcomes matter. We use the Centers for Disease Control and Prevention's (CDC) "Framework for Program Evaluation in Public Health" as a guide for developing an evaluation plan. Just as using a roadmap facilitates progress on a long journey, a well-written evaluation plan can clarify the direction your evaluation takes and facilitate achievement of the evaluation's objectives.

Human System Risk Management for Space Flight

NASA Technical Reports Server (NTRS)

Davis, Jeffrey

2015-01-01

This brief abstract reviews the development of the current day approach to human system risk management for space flight and the development of the critical components of this process over the past few years. The human system risk management process now provides a comprehensive assessment of each human system risk by design reference mission (DRM) and is evaluated not only for mission success but also for long-term health impacts for the astronauts. The discipline of bioastronautics is the study of the biological and medical effects of space flight on humans. In 1997, the Space Life Sciences Directorate (SLSD) initiated the Bioastronautics Roadmap (Roadmap) as the "Critical Path Roadmap", and in 1998 participation in the roadmap was expanded to include the National Space Biomedical Research Institute (NSBRI) and the external community. A total of 55 risks and 250 questions were identified and prioritized and in 2000, the Roadmap was base-lined and put under configuration control. The Roadmap took into account several major advisory committee reviews including the Institute of Medicine (IOM) "Safe Passage: Astronaut care for Exploration Missions", 2001. Subsequently, three collaborating organizations at NASA HQ (Chief Health and Medical Officer, Office of Space Flight and Office of Biological & Physical Research), published the Bioastronautics Strategy in 2003, that identified the human as a "critical subsystem of space flight" and noted that "tolerance limits and safe operating bands must be established" to enable human space flight. These offices also requested a review by the IOM of the Roadmap and that review was published in October 2005 as "A Risk Reduction Strategy for Human Exploration of Space: A Review of NASA's Bioastronautics Roadmap", that noted several strengths and weaknesses of the Roadmap and made several recommendations. In parallel with the development of the Roadmap, the Office of the Chief Health and Medical Officer (OCHMO) began a process in 2004 of evaluating the tolerance limits and safe operating bands called for in the Bioastronautics Strategy. Over the next several years, the concept of the "operating bands" were turned into Space Flight Human System Standards (SFHSS), developed by the technical resources of the SLSD at the NASA Johnson Space Center (JSC). These standards were developed and reviewed at the SLSD and then presented to the OCHMO for acceptance. The first set of standards was published in 2007 as the NASA-STD-3001, Volume 1, Crew Health that elaborated standards for several physiological areas such as cardiovascular, musculoskeletal, radiation exposure and nutrition. Volume 2, Human Factors, Habitability and Human Health was published in 2011, along with development guidance in the Human Integration Design Handbook (HIDH). Taken together, the SFHSS Volumes 1 and 2, and the HIDH replaced the NASA-STD-3000 with new standards and revisions of the older document. Three other changes were also taking place that facilitated the development of the human system risk management approach. In 2005, the life sciences research and development portfolio underwent a comprehensive review through the Exploration Systems Architecture Study (ESAS) that resulted in the reformulation of the Bioastronautics Program into Human Research Program (HRP) that was focused on appropriate mitigation results for high priority human health risks. The baseline HRP budget was established in August 2005. In addition, the OCHMO formulated the Health and Medical Technical Authority (HMTA) in 2006 that established the position of the Chief Medical Officer (CMO) at the NASA JSC along with other key technical disciplines, and the OCHMO became the responsible office for the SFHSS as noted above. The final change was the establishment in 2008 of the Human System Risk Board (HSRB), chaired by the CMO with representation from the HRP, SLSD management and technical experts. The HSRB then began to review all human system risks, established a comprehensive risk management and configuration management plan and data sharing policy. These major developments of standards, the HRP, the HMTA and a forum for review of human system risks (HSRB) facilitated the integration of human research, medical operations, systems engineering and many other disciplines in the comprehensive review of human system risks. The HSRB began a comprehensive review of all potential inflight medical conditions and events and over the course of several reviews consolidated the number of human system risks to 30 where the greatest emphasis is placed for investing program dollars for risk mitigation. The HSRB considers all available evidence from human research, medical operations and occupational surveillance in assessing the risks for appropriate mitigation and future work. All applicable DRMs (low earth orbit 6 and 12 months, deep space sortie for 30 days and 1 year, a one year lunar mission, and a planetary mission for 3 years) are considered as human system risks are modified by the hazards associated with space flight such as microgravity, exposure to radiation, distance from the earth, isolation and a closed environment. Each risk has a summary assessment representing the state of knowledge/evidence base for that risk, the available risk mitigations, traceability to the SFHSS and program requirements, and future work required. These data then can drive coordinated budgets across the HRP, the International Space Station, Crew Health and Safety and Advanced Exploration System budgets. These risk assessments were completed for 6 DRMs in December of 2014 and serve as the baseline for which subsequent research and technology development and crew health care portfolios can be assessed. The HSRB will review each risk at least annually and especially when new information is available that must be considered for effective risk mitigation. The current status of each risk can be reported to program management for operations, budget reviews and general oversight of the human system risk management program.

Integration of dual source computed tomography with magnetic navigation system for percutaneous coronary intervention: a feasibility study.

PubMed

Li, Chunjian; Tang, Lijun; Yang, Zhijian; Cao, Kejiang

2011-12-01

To investigate the feasibility of integration of the dual source computed tomography (DSCT) and magnetic navigation system (MNS) to guide percutaneous coronary intervention (PCI). MNS has proven to be feasible for yielding high rates of procedural success for PCI. DSCT coronary angiography (DSCT-CA) may provide a roadmap of a target vessel and serve as a reference route for MNS. Combination of these two technologies might decrease the contrast use, fluoroscopy exposure, and be beneficial to the intervention of the totally occluded lesions. Twenty-five patients with positive results of DSCT-CA and indications for PCI were included. CT images were transferred to MNS, and target vessels were extracted and registered to X-ray system as a roadmap. DSCT-CA and MNS-assisted PCIs were successfully performed in 25 of the 26 target vessels (96.2%), with the mean guidewire crossing time of 100.0 (25-75% inter-quartile ranges (IQR): 70.7-157.8) sec, mean total radiation dosage of 268.1 (IQR: 150.5-527.0) μGym(2) , or 42.0 (IQR: 23.0-70.0) mGy, respectively. The contrast usage for guidewire positioning was 0 (IQR: 0-3.0) ml for the successfully crossed lesions. Both of the two totally occluded lesions in this study were successfully crossed with guidewires under the guidance of the DSCT-CA derived roadmap. Integration of DSCT with MNS for PCI is feasible. This integration of advanced modalities might decrease contrast usage, lower fluoroscopy exposure for guidewire positioning, and might also play a role in totally occluded lesions. Copyright © 2011 Wiley Periodicals, Inc.

Development of a web-based intervention for the indicated prevention of depression.

PubMed

Kelders, Saskia M; Pots, Wendy T M; Oskam, Maarten Jan; Bohlmeijer, Ernst T; van Gemert-Pijnen, Julia E W C

2013-02-20

To reduce the large public health burden of the high prevalence of depression, preventive interventions targeted at people at risk are essential and can be cost-effective. Web-based interventions are able to provide this care, but there is no agreement on how to best develop these applications and often the technology is seen as a given. This seems to be one of the main reasons that web-based interventions do not reach their full potential. The current study describes the development of a web-based intervention for the indicated prevention of depression, employing the CeHRes (Center for eHealth Research and Disease Management) roadmap. The goals are to create a user-friendly application which fits the values of the stakeholders and to evaluate the process of development. The employed methods are a literature scan and discussion in the contextual inquiry; interviews, rapid prototyping and a requirement session in the value specification stage; and user-based usability evaluation, expert-based usability inspection and a requirement session in the design stage. The contextual inquiry indicated that there is a need for easily accessible interventions for the indicated prevention of depression and web-based interventions are seen as potentially meeting this need. The value specification stage yielded expected needs of potential participants, comments on the usefulness of the proposed features and comments on two proposed designs of the web-based intervention. The design stage yielded valuable comments on the system, content and service of the web-based intervention. Overall, we found that by developing the technology, we successfully (re)designed the system, content and service of the web-based intervention to match the values of stakeholders. This study has shown the importance of a structured development process of a web-based intervention for the indicated prevention of depression because: (1) it allows the development team to clarify the needs that have to be met for the intervention to be of use to the target audience; and (2) it yields feedback on the design of the application that is broader than color and buttons, but encompasses comments on the quality of the service that the application offers.

Development of a web-based intervention for the indicated prevention of depression

PubMed Central

2013-01-01

Background To reduce the large public health burden of the high prevalence of depression, preventive interventions targeted at people at risk are essential and can be cost-effective. Web-based interventions are able to provide this care, but there is no agreement on how to best develop these applications and often the technology is seen as a given. This seems to be one of the main reasons that web-based interventions do not reach their full potential. The current study describes the development of a web-based intervention for the indicated prevention of depression, employing the CeHRes (Center for eHealth Research and Disease Management) roadmap. The goals are to create a user-friendly application which fits the values of the stakeholders and to evaluate the process of development. Methods The employed methods are a literature scan and discussion in the contextual inquiry; interviews, rapid prototyping and a requirement session in the value specification stage; and user-based usability evaluation, expert-based usability inspection and a requirement session in the design stage. Results The contextual inquiry indicated that there is a need for easily accessible interventions for the indicated prevention of depression and web-based interventions are seen as potentially meeting this need. The value specification stage yielded expected needs of potential participants, comments on the usefulness of the proposed features and comments on two proposed designs of the web-based intervention. The design stage yielded valuable comments on the system, content and service of the web-based intervention. Conclusions Overall, we found that by developing the technology, we successfully (re)designed the system, content and service of the web-based intervention to match the values of stakeholders. This study has shown the importance of a structured development process of a web-based intervention for the indicated prevention of depression because: (1) it allows the development team to clarify the needs that have to be met for the intervention to be of use to the target audience; and (2) it yields feedback on the design of the application that is broader than color and buttons, but encompasses comments on the quality of the service that the application offers. PMID:23425322

National Aeronautics and Space Administration (NASA) Environmental Control and Life Support (ECLS) Integrated Roadmap Development

NASA Technical Reports Server (NTRS)

Metcalf, Jordan; Peterson, Laurie; Carrasquillo, Robyn; Bagdigian, Robert

2012-01-01

Although NASA is currently considering a number of future human space exploration mission concepts, detailed mission requirements and vehicle architectures remain mostly undefined, making technology investment strategies difficult to develop and sustain without a top-level roadmap to serve as a guide. This paper documents the process and results of an effort to define a roadmap for Environmental Control and Life Support Systems (ECLSS) capabilities required to enhance the long-term operation of the International Space Station (ISS) as well as enable beyond-Low Earth Orbit (LEO) human exploration missions. Three generic mission types were defined to serve as a basis for developing a prioritized list of needed capabilities and technologies. Those are 1) a short duration micro-gravity mission; 2) a long duration microgravity mission; and 3) a long duration partial gravity (surface) exploration mission. To organize the effort, a functional decomposition of ECLSS was completed starting with the three primary functions: atmosphere, water, and solid waste management. Each was further decomposed into sub-functions to the point that current state-of-the-art (SOA) technologies could be tied to the sub-function. Each technology was then assessed by NASA subject matter experts as to its ability to meet the functional needs of each of the three mission types. When SOA capabilities were deemed to fall short of meeting the needs of one or more mission types, those gaps were prioritized in terms of whether or not the corresponding capabilities enable or enhance each of the mission types. The result was a list of enabling and enhancing capability needs that can be used to guide future ECLSS development, as well as a list of existing hardware that is ready to go for exploration-class missions. A strategy to fulfill those needs over time was then developed in the form of a roadmap. Through execution of this roadmap, the hardware and technologies intended to meet exploration needs will, in many cases, directly benefit the ISS operational capability, benefit the Multi-Purpose Crew Vehicle (MPCV), and guide long-term technology investments for longer duration missions.

Energy Efficiency Roadmap for Uganda, Making Energy Efficiency Count. Executive Summary

DOE Office of Scientific and Technical Information (OSTI.GOV)

de la Rue du Can, Stephane; Pudleiner, David; Jones, David

Like many countries in Sub-Saharan Africa, Uganda has focused its energy sector investments largely on increasing energy access by increasing energy supply. The links between energy efficiency and energy access, the importance of energy efficiency in new energy supply, and the multiple benefits of energy efficiency for the level and quality of energy available, have been largely overlooked. Implementing energy efficiency in parallel with expanding both the electricity grid and new clean energy generation reduces electricity demand and helps optimize the power supply so that it can serve more customers reliably at minimum cost. Ensuring efficient appliances are incorporated intomore » energy access efforts provides improved energy services to customers. Energy efficiency is an important contributor to access to modern energy. This Energy Efficiency Roadmap for Uganda (Roadmap) is a response to the important role that electrical energy efficiency can play in meeting Uganda’s energy goals. Power Africa and the United Nations Sustainable Energy for All (SEforALL) initiatives collaborated with more than 24 stakeholders in Uganda to develop this document. The document estimates that if the most efficient technologies on the market were adopted, 2,224 gigawatt hours could be saved in 2030 across all sectors, representing 31% of the projected load. This translates into 341 megawatts of peak demand reductions, energy access to an additional 6 million rural customers and reduction of carbon dioxide emissions by 10.6 million tonnes in 2030. The Roadmap also finds that 91% of this technical potential is cost-effective, and 47% is achievable under conservative assumptions. The Roadmap prioritizes recommendations for implementing energy efficiency and maximizing benefits to meet the goals and priorities established in Uganda’s 2015 SEforALL Action Agenda. One important step is to create and increase demand for efficiency through long-term enabling policies and financial incentives combined with development of technical expertise in the labor force to allow for the promotion of new business models, such as energy service companies. A combination of enabling policies, financial schemes, regulations, enforcement, and skill development are needed to open the energy efficiency market.« less

Roadmap evolution: from NTRS to ITRS, from ITRS 2.0 to IRDS

NASA Astrophysics Data System (ADS)

Gargini, Paolo A.

2017-10-01

The semiconductor industry benefitted from roadmap guidance since the mid-60s. The roadmap anticipated and outlined the main needs of the semiconductor industry for years to come and identified future challenges and possible solutions. Making transistor smaller by means of advanced lithographic technologies enabled both increased integration levels and improved IC performance. The roadmap methodology allowed the removal of multiple "red brick walls". The NTRS and the ITRS constituted primarily a "bottom up" approach as standard microprocessors and memories where introduced at a blistering pace barely allowing time for system houses to integrate them in their products. The 1998 ITRS provided the vision that triggered research, development and manufacturing communities to develop a completely new transistor structure in addition to replacing aluminum interconnects with a more advanced technology. The advent of Foundries and Fabless companies transformed the electronics industry into a "top down" driven industry in the past 15 years. The ITRS adjusted to this new ecosystem and morphed into the International Roadmap for Devices and Systems (IRDS) sponsored by IEEE. The IRDS is addressing the requirements and needs of the renewed electronics industry. Furthermore, by the middle of the next decade the ability to layout integrated circuits in a 2D geometry grid will reach fundamental physical limits and the aggressive conversion to 3D architecture for integrated circuit must be pursued across the board as an avenue to continuously increasing transistor count and improving performance. EUV technology is finally approaching the manufacturing stage but with the advent of 3D monolithically integrated heterogeneous circuits approaching in the not-toodistant future should the semiconductor industry concentrate its resources on the next lithographic technology generation in order to enhance resolution or on providing a smooth transition to the new revolutionary 3D architecture of integrated circuits? It is essential for the whole semiconductor industry to come together and make fundamental choices leading to a cooperative and synchronized allocation of adequate resources to produce viable solutions that once introduced in a timely manner into manufacturing will enable the continuation of the growth of the electronic industry at a pace comparable or exceeding historical trends.

Novel Three-Dimensional Image Fusion Software to Facilitate Guidance of Complex Cardiac Catheterization : 3D image fusion for interventions in CHD.

PubMed

Goreczny, Sebastian; Dryzek, Pawel; Morgan, Gareth J; Lukaszewski, Maciej; Moll, Jadwiga A; Moszura, Tomasz

2017-08-01

We report initial experience with novel three-dimensional (3D) image fusion software for guidance of transcatheter interventions in congenital heart disease. Developments in fusion imaging have facilitated the integration of 3D roadmaps from computed tomography or magnetic resonance imaging datasets. The latest software allows live fusion of two-dimensional (2D) fluoroscopy with pre-registered 3D roadmaps. We reviewed all cardiac catheterizations guided with this software (Philips VesselNavigator). Pre-catheterization imaging and catheterization data were collected focusing on fusion of 3D roadmap, intervention guidance, contrast and radiation exposure. From 09/2015 until 06/2016, VesselNavigator was applied in 34 patients for guidance (n = 28) or planning (n = 6) of cardiac catheterization. In all 28 patients successful 2D-3D registration was performed. Bony structures combined with the cardiovascular silhouette were used for fusion in 26 patients (93%), calcifications in 9 (32%), previously implanted devices in 8 (29%) and low-volume contrast injection in 7 patients (25%). Accurate initial 3D roadmap alignment was achieved in 25 patients (89%). Six patients (22%) required realignment during the procedure due to distortion of the anatomy after introduction of stiff equipment. Overall, VesselNavigator was applied successfully in 27 patients (96%) without any complications related to 3D image overlay. VesselNavigator was useful in guidance of nearly all of cardiac catheterizations. The combination of anatomical markers and low-volume contrast injections allowed reliable 2D-3D registration in the vast majority of patients.

A roadmap and best practices for organizations to reduce racial and ethnic disparities in health care.

PubMed

Chin, Marshall H; Clarke, Amanda R; Nocon, Robert S; Casey, Alicia A; Goddu, Anna P; Keesecker, Nicole M; Cook, Scott C

2012-08-01

Over the past decade, researchers have shifted their focus from documenting health care disparities to identifying solutions to close the gap in care. Finding Answers: Disparities Research for Change, a national program of the Robert Wood Johnson Foundation, is charged with identifying promising interventions to reduce disparities. Based on our work conducting systematic reviews of the literature, evaluating promising practices, and providing technical assistance to health care organizations, we present a roadmap for reducing racial and ethnic disparities in care. The roadmap outlines a dynamic process in which individual interventions are just one part. It highlights that organizations and providers need to take responsibility for reducing disparities, establish a general infrastructure and culture to improve quality, and integrate targeted disparities interventions into quality improvement efforts. Additionally, we summarize the major lessons learned through the Finding Answers program. We share best practices for implementing disparities interventions and synthesize cross-cutting themes from 12 systematic reviews of the literature. Our research shows that promising interventions frequently are culturally tailored to meet patients' needs, employ multidisciplinary teams of care providers, and target multiple leverage points along a patient's pathway of care. Health education that uses interactive techniques to deliver skills training appears to be more effective than traditional didactic approaches. Furthermore, patient navigation and engaging family and community members in the health care process may improve outcomes for minority patients. We anticipate that the roadmap and best practices will be useful for organizations, policymakers, and researchers striving to provide high-quality equitable care.

Creating Communications, Computing, and Networking Technology Development Road Maps for Future NASA Human and Robotic Missions

NASA Technical Reports Server (NTRS)

Bhasin, Kul; Hayden, Jeffrey L.

2005-01-01

For human and robotic exploration missions in the Vision for Exploration, roadmaps are needed for capability development and investments based on advanced technology developments. A roadmap development process was undertaken for the needed communications, and networking capabilities and technologies for the future human and robotics missions. The underlying processes are derived from work carried out during development of the future space communications architecture, an d NASA's Space Architect Office (SAO) defined formats and structures for accumulating data. Interrelationships were established among emerging requirements, the capability analysis and technology status, and performance data. After developing an architectural communications and networking framework structured around the assumed needs for human and robotic exploration, in the vicinity of Earth, Moon, along the path to Mars, and in the vicinity of Mars, information was gathered from expert participants. This information was used to identify the capabilities expected from the new infrastructure and the technological gaps in the way of obtaining them. We define realistic, long-term space communication architectures based on emerging needs and translate the needs into interfaces, functions, and computer processing that will be required. In developing our roadmapping process, we defined requirements for achieving end-to-end activities that will be carried out by future NASA human and robotic missions. This paper describes: 10 the architectural framework developed for analysis; 2) our approach to gathering and analyzing data from NASA, industry, and academia; 3) an outline of the technology research to be done, including milestones for technology research and demonstrations with timelines; and 4) the technology roadmaps themselves.

Magnetic navigation system and CT roadmap-assisted percutaneous coronary intervention: a comparison to the conventional approach.

PubMed

Hao, Ruina; Zhang, Qiu; Xu, Zhuowen; Tang, Lijun; Yang, Zhijian; Cao, Kejiang; Li, Chunjian

2013-04-01

Computed tomography coronary angiography (CTCA) has been successfully integrated with the magnetic navigation system (MNS) to facilitate a roadmap-assisted percutaneous coronary intervention (PCI). The aim of this study was to compare this new approach of PCI versus conventional PCI regarding the difference of contrast usage, x-ray exposure, procedure success, and in-hospital expenses. Thirty-eight patients with stable coronary artery disease and coronary artery lesions of ≥70% diameter stenosis diagnosed by both pre-procedure CTCA and coronary angiography (CAG) were enrolled to receive the MNS and CT roadmap-assisted PCI. Another 38 patients were consecutively recruited to receive conventional PCI, matched with the MNS group by the vessel and lesion type base on American College of Cardiology/American Heart Association criteria. Regarding the process of the guidewire placement, wherein the technical difference of the two procedures exists, the median contrast usage for guidewire crossing was significantly lower in the MNS group than in the conventional group [0.0 mL (interquartile range [IQR], 0.0-3.0 mL) vs 5.0 mL (IQR, 3.1-6.8 mL); P<.001], with zero contrast usage in 25 of the 44 guidewire placements in the MNS group, but in none of the conventional group; the radiation dosage for guidewire crossing in the MNS group was also significantly lower than in the conventional group (235.8 μGym² [IQR, 134.9-455.1 μGym²] vs 364.4 μGym² [IQR, 223.4-547.2 μGym²]; P=.033). There were no significant differences between the two groups concerning the total contrast usage, total radiation dosage of the PCI, the procedural fees, or the overall in-hospital expenses. All of the enrolled vessels were successfully intervened in both groups. In PCI of simple lesions, the application of CT guidance and magnetic navigation had modest impacts on radiation dosage and contrast usage for wire crossing, but no impact on overall radiation dosage or contrast usage for the procedure. In addition, the use of CT roadmap and MNS was likely more expensive compared to PCI using conventional radiographic technique.

A Governance Roadmap and Framework for EarthCube

NASA Astrophysics Data System (ADS)

Governance Steering Committee, EarthCube

2013-04-01

EarthCube is a process and an outcome, established to transform the conduct of research through the development of community-guided cyberinfrastructure for the Geosciences as the prototype for potential deployment across all domain sciences. EarthCube aims to create a knowledge management system and infrastructure that integrates all Earth system and human dimensions data in an open transparent, and inclusive manner. EarthCube requires broad community participation in concept, framework, and implementation and must not be hindered by rigid preconceptions. We discovered widely varying interpretations, expectations, and assumptions about governance among EarthCube participants. Our definition of governance refers to the processes, structure and organizational elements that determine, within an organization or system of organizations, how power is exercised, how stakeholders have their say, how decisions are made, and how decision makers are held accountable. We have learned, from historic infrastructure case studies, background research on governance and from community feedback during this roadmap process, that other types of large-scale, complex infrastructures, including the Internet, have no central control, administration, or management. No national infrastructure that we examined is governed by a single entity, let alone a single governance archetype. Thus we feel the roadmap process must accommodate a governance system or system of systems that may have a single governing entity, particularly at the start, but can evolve into a collective of governing bodies as warranted, in order to be successful. A fast-track process during Spring, 2012 culminated in a Governance Roadmap delivered to an NSF-sponsored charrette in June with an aggressive timetable to define and implement a governance structure to enable the elements of EarthCube to become operational expeditiously. Our goal is to help ensure the realization of this infrastructure sooner, more efficiently, and more effectively, by providing a community endorsed Governance Framework, released in September of 2012. The Framework, and corresponding community outreach, maximizes engagement of the broader EarthCube community, which in turn minimizes the risks that the community will not adopt EarthCube in its development and final states. The target stakeholder community includes academia, government, and the private-sector, both nationally and internationally. http://earthcube.ning.com/group/governance

Mediterranean studies of cardiovascular disease and hyperglycemia: analytical modeling of population socio-economic transitions (MedCHAMPS)--rationale and methods.

PubMed

Maziak, Wasim; Critchley, Julia; Zaman, Shahaduz; Unwin, Nigel; Capewell, Simon; Bennett, Kathleen; Unal, Belgin; Husseini, Abdullatif; Romdhane, Habiba Ben; Phillimore, Peter

2013-08-01

In response to the escalating epidemic of cardiovascular disease (CVD) in the Mediterranean Region (MR), an international collaboration aiming at understanding the burden of CVD and evaluating cost-effective strategies to combat it was recently established. This paper describes the rationale and methods of the project MedCHAMPS to disseminate this successful experience. The framework of MedCHAMPS is exceptional in combining multiple disciplines (e.g. epidemiology, anthropology, economics), countries [Turkey, Syria, occupied Palestinian territory (oPt), Tunisia, UK, Ireland], research methods (situational and policy analysis, quantitative and qualitative studies, statistical modeling), and involving local stakeholders at all levels to assess trends of CVD/diabetes in the society and attributes of the local health care systems to provide optimal policy recommendations to reduce the burden of CVD/diabetes. MedCHAMPS provides policy makers in the MR and beyond needed guidance about the burden of CVD, and best cost-effective ways to combat it. Our approach of building developed-developing countries collaboration also provides a roadmap for other researchers seeking to build research base into CVD epidemiology and prevention in developing countries.

100% Clean, Renewable Wind, Water, and Solar Roadmaps for 139 Countries of the World

NASA Astrophysics Data System (ADS)

Jacobson, M. Z.

2015-12-01

Significant prior research has focused on the health, climate, and other environmental and social impacts of gas and aerosol particle emissions from fossil fuel and biofuel combustion. Given the magnitude and costs of the impacts, large-scale conversions of these fuels to non-emitting sources of energy are warranted. This talk discusses technical and economic roadmaps to convert the energy infrastructures of each of 139 countries of the world to those powered by 100% non-emitting wind, water, and sunlight (WWS) for all purposes, namely electricity, transportation, heating/cooling, industry, and agriculture/forestry/fishing, after energy efficiency measures have been accounted for. These roadmaps are developed with a methodology similar to that recently derived for each of the 50 United States. Reliability of 100% WWS systems is crucial. To that end, results showing the ability of the United States to maintain a 100% reliable grid with a 100% WWS system are discussed as well. Please see http://web.stanford.edu/group/efmh/jacobson/Articles/I/WWS-50-USState-plans.html for more information.

Proceedings of the 2003 NASA/JPL Workshop on Fundamental Physics in Space

NASA Technical Reports Server (NTRS)

Strayer, Don (Editor)

2003-01-01

The 2003 Fundamental Physics workshop included presentations ranging from forces acting on RNA to properties of clouds of degenerate Fermi atoms, to techniques to probe for a added space-time dimensions, and to flight hardware for low temperature experiments, amongst others. Mark Lee from NASA Headquarters described the new strategic plan that NASA has developed under Administrator Sean O'Keefe's leadership. Mark explained that the Fundamental Physics community now needs to align its research program and the roadmap describing the long-term goals of the program with the NASA plan. Ulf Israelsson of JPL discussed how the rewrite of the roadmap will be implemented under the leadership of the Fundamental Physics Discipline Working Group (DWG). Nick Bigelow, chair of the DWG, outlined how investigators can contribute to the writing of the roadmap. Results of measurements on very cold clouds of Fermi atoms near a Feshbach resonance were described by three investigators. Also, new measurements relating to tests of Einstein equivalence were discussed. Investigators also described methods to test other aspects of Einstein's relativity theories.

Guiding Requirements for Designing Life Support System Architectures for Crewed Exploration Missions Beyond Low-Earth Orbit

NASA Technical Reports Server (NTRS)

Perry, Jay L.; Sargusingh, Miriam J.; Toomarian, Nikzad

2016-01-01

The National Aeronautics and Space Administration's (NASA) technology development roadmaps provide guidance to focus technological development in areas that enable crewed exploration missions beyond low-Earth orbit. Specifically, the technology area roadmap on human health, life support and habitation systems describes the need for life support system (LSS) technologies that can improve reliability and in-flight maintainability within a minimally-sized package while enabling a high degree of mission autonomy. To address the needs outlined by the guiding technology area roadmap, NASA's Advanced Exploration Systems (AES) Program has commissioned the Life Support Systems (LSS) Project to lead technology development in the areas of water recovery and management, atmosphere revitalization, and environmental monitoring. A notional exploration LSS architecture derived from the International Space has been developed and serves as the developmental basis for these efforts. Functional requirements and key performance parameters that guide the exploration LSS technology development efforts are presented and discussed. Areas where LSS flight operations aboard the ISS afford lessons learned that are relevant to exploration missions are highlighted.

Addressing learner disorientation: give them a roadmap.

PubMed

Crossley, James G M

2014-08-01

This article describes the problem of disorientation in students as they become doctors. Disorientation arises because students have a poor or inaccurate understanding of what they are training to become. If they do not know what they are becoming it is hard for them to prioritise and contextualise their learning, to make sense of information about where they are now (assessment and feedback) or to determine the steps they need to take to develop (formative feedback and "feedforward"). It is also a barrier to the early development of professional identity. Using the analogy of a map, the paper describes the idea of a curriculum that is articulated as a developmental journey--a "roadmap curriculum". This is not incompatible with a competency-based curriculum, and certainly requires the same integration of knowledge, skills and attitudes. However, the semantic essence of a roadmap curriculum is fundamentally different; it must describe the pathway or pathways of development toward being a doctor in ways that are both authentic to qualified doctors and meaningful to learners. Examples from within and outside medicine are cited. Potential advantages and implications of this kind of curricular reform are discussed.

Unique Non-Keplerian Orbit Vantage Locations for Sun-Earth Connection and Earth Science Vision Roadmaps

NASA Technical Reports Server (NTRS)

Folta, David; Young, Corissa; Ross, Adam

2001-01-01

The purpose of this investigation is to determine the feasibility of attaining and maintaining unique non-Keplerian orbit vantage locations in the Earth/Moon environment in order to obtain continuous scientific measurements. The principal difficulty associated with obtaining continuous measurements is the temporal nature of astrodynamics, i.e., classical orbits. This investigation demonstrates advanced trajectory designs to meet demanding science requirements which cannot be met following traditional orbital mechanic logic. Examples of continuous observer missions addressed include Earth pole-sitters and unique vertical libration orbits that address Sun-Earth Connection and Earth Science Vision roadmaps.

A Roadmap to College Readiness

ERIC Educational Resources Information Center

Mann, Sharmila Basu; Martin, Rebecca

2016-01-01

To successfully participate in today's global economy, young people must graduate high school with the skills and competencies that allow them to pursue further study and meaningful work. Yet the data around successful transition from high school to higher education, and then to the completion of a degree, show some alarming trends. In 2007, 70.5%…

SPECS: The Kilometer-baseline Far-IR Interferometer in NASA's Space Science Roadmap Presentation

NASA Technical Reports Server (NTRS)

Abel, Tom; Allen, Ron; Benford, Dominic; Blain, Andrew; Bombardelli, Claudio; Calzetti, Daniela; DiPirro, Michael J.; Ehrenfreund, Pascale; Evans, Neal; Fischer, Jackie

2004-01-01

A viewgraph presentation describing the Submillimeter Probe of the Evolution of Cosmic Structure (SPECS) mission is shown. The topics include: 1) Context: community planning and study status; 2) Science goals; 3) Mission requirements; 4) Mission concepts for SPIRIT and SPECS; and 5) Tethered formation flying, a key enabling technology.

Two High Schools and the Road to Full Inclusion: A Comparison Study

ERIC Educational Resources Information Center

Pierson, Melinda R.; Howell, Erica J.

2013-01-01

This article documents a roadmap for developing fully inclusive school sites at the secondary level. Full inclusion is defined as placement in the general education classroom for all students with disabilities. Specifically, two large high schools located in suburban areas attempted to fully include over 300 students identified as needing special…

A study of complications affecting surgery performance: an ISM-based roadmap to patient flow.

PubMed

Dev, Navin K; Shankar, Ravi; Arvind, Kamal

2013-01-01

The aim of this study is to highlight the value of the success rate performance of a surgery while planning patient flow within a supply chain of a health care organization/hospital. The paper has considered one of the common surgeries, cataract, and the complications that subsequently result from this surgery. The study employs interpretive structural modeling (ISM) approach to draw a roadmap to study various complications causing cataract that subsequently help in planning and coordination of patient flow. The study finds that there is a hierarchy of causes and certain complications, the persistence of which gives a higher success rate performance in cataract surgery as compared to others. The paper provides leverage to the decision maker while organizing the patient flow depending upon the information of hierarchy of complication of a disease, and accordingly ensures the availability of resources to the patient. The study is of value in identifying the degree of complications from cataract surgery. Given the degree of complication, the patient logistics can be planned myopically in a health care organization which largely depends upon the degree of success rate. The paper attempts to suggest that the hierarchy obtained through ISM can be implemented in the modules of an enterprise resource planning (ERP) set up.

Zero expansion glass ceramic ZERODUR® roadmap for advanced lithography

NASA Astrophysics Data System (ADS)

Westerhoff, Thomas; Jedamzik, Ralf; Hartmann, Peter

2013-04-01

The zero expansion glass ceramic ZERODUR® is a well-established material in microlithography in critical components as wafer- and reticle-stages, mirrors and frames in the stepper positioning and alignment system. The very low coefficient of thermal expansion (CTE) and its extremely high CTE homogeneity are key properties to achieve the tight overlay requirements of advanced lithography processes. SCHOTT is continuously improving critical material properties of ZERODUR® essential for microlithography applications according to a roadmap driven by the ever tighter material specifications broken down from the customer roadmaps. This paper will present the SCHOTT Roadmap for ZERODUR® material property development. In the recent years SCHOTT established a physical model based on structural relaxation to describe the coefficient of thermal expansion's temperature dependence. The model is successfully applied for the new expansion grade ZERODUR® TAILORED introduced to the market in 2012. ZERODUR® TAILORED delivers the lowest thermal expansion of ZERODUR® products at microlithography tool application temperature allowing for higher thermal stability for tighter overlay control in IC production. Data will be reported demonstrating the unique CTE homogeneity of ZERODUR® and its very high reproducibility, a necessary precondition for serial production for microlithography equipment components. New data on the bending strength of ZERODUR® proves its capability to withstand much higher mechanical loads than previously reported. Utilizing a three parameter Weibull distribution it is possible to derive minimum strength values for a given ZERODUR® surface treatment. Consequently the statistical uncertainties of the earlier approach based on a two parameter Weibull distribution have been eliminated. Mechanical fatigue due to stress corrosion was included in a straightforward way. The derived formulae allows calculating life time of ZERODUR® components for a given stress load or the allowable maximum stress for a minimum required life time.

COMET strongly supported the development and implementation of medium-term topical research roadmaps consistent with the ALLIANCE Strategic Research Agenda.

PubMed

Garnier-Laplace, J; Vandenhove, H; Beresford, N; Muikku, M; Real, A

2018-03-01

The ALLIANCE 6 Strategic Research Agenda (SRA) initiated by the STAR 7 Network of Excellence and integrated in the research strategy implemented by the COMET consortium, defines a long-term vision of the needs for, and implementation of, research in radioecology. This reference document, reflecting views from many stakeholders groups and researchers, serves as an input to those responsible for defining EU research call topics through the ALLIANCE SRA statement delivered each year to the EJP-CONCERT 8 (2015-2020). This statement highlights a focused number of priorities for funding. Research in radioecology and related sciences is justified by various drivers, such as policy changes, scientific advances and knowledge gaps, radiological risk perception by the public, and a growing awareness of interconnections between human and ecosystem health. The SRA is being complemented by topical roadmaps that have been initiated by the COMET 9 EC-funded project, with the help and endorsement of the ALLIANCE. The strategy underlying roadmap development is driven by the need for improved mechanistic understanding across radioecology. By meeting this need, we can provide fit-for-purpose human and environmental impact/risk assessments in support of the protection of man and the environment in interaction with society and for the three exposure situations defined by the ICRP (i.e., planned, existing and emergency). Within the framework of the EJP-CONCERT the development of a joint roadmap is under discussion among all the European research platforms and will highlight the major research needs for the whole radiation protection field and how these are likely to be addressed by 2030.

Action-based Dynamical Modeling for the Milky Way Disk: The Influence of Spiral Arms

NASA Astrophysics Data System (ADS)

Trick, Wilma H.; Bovy, Jo; D'Onghia, Elena; Rix, Hans-Walter

2017-04-01

RoadMapping is a dynamical modeling machinery developed to constrain the Milky Way’s (MW) gravitational potential by simultaneously fitting an axisymmetric parametrized potential and an action-based orbit distribution function (DF) to discrete 6D phase-space measurements of stars in the Galactic disk. In this work, we demonstrate RoadMapping's robustness in the presence of spiral arms by modeling data drawn from an N-body simulation snapshot of a disk-dominated galaxy of MW mass with strong spiral arms (but no bar), exploring survey volumes with radii 500 {pc}≤slant {r}\\max ≤slant 5 {kpc}. The potential constraints are very robust, even though we use a simple action-based DF, the quasi-isothermal DF. The best-fit RoadMapping model always recovers the correct gravitational forces where most of the stars that entered the analysis are located, even for small volumes. For data from large survey volumes, RoadMapping finds axisymmetric models that average well over the spiral arms. Unsurprisingly, the models are slightly biased by the excess of stars in the spiral arms. Gravitational potential models derived from survey volumes with at least {r}\\max =3 {kpc} can be reliably extrapolated to larger volumes. However, a large radial survey extent, {r}\\max ˜ 5 {kpc}, is needed to correctly recover the halo scale length. In general, the recovery and extrapolability of potentials inferred from data sets that were drawn from inter-arm regions appear to be better than those of data sets drawn from spiral arms. Our analysis implies that building axisymmetric models for the Galaxy with upcoming Gaia data will lead to sensible and robust approximations of the MW’s potential.

Roadmap to a tobacco epidemic: transnational tobacco companies invade Indonesia.

PubMed

Hurt, Richard D; Ebbert, Jon O; Achadi, Anhari; Croghan, Ivana T

2012-05-01

Indonesia is the world's fifth largest cigarette market in the world but for decades, transnational tobacco companies (TTCs) have had limited success infiltrating this market, due to their inability to compete in the kretek market. Kreteks are clove/tobacco cigarettes that most Indonesians smoke. To determine how Phillip Morris International (PMI) and British American Tobacco (BAT) have now successfully achieved a substantial market presence in Indonesia. We analyzed previously secret, tobacco industry documents, corporate reports on Indonesia operations, the Tobacco Trade press, Indonesia media, and "The Roadmap". Internal, corporate documents from BAT and PMI demonstrate that they had known for decades that kreteks are highly carcinogenic. Despite that knowledge, BAT and PMI now own and heavily market these products, as well as new more westernised versions of kreteks. BAT and PMI used their successful basic strategy of keeping cigarettes affordable by maintaining the social responsibility of smoking and opposing smoke-free workplace laws but in the 21st century, they added the acquisition of and westernisation of domestic kretek manufacturers as an additional strategy. These acquisitions allowed them to assert influences on health policy in Indonesia and to grow their business under current government policy embodied in the 2007-2020 Roadmap of Tobacco Products Industry and Excise Policy which calls for increased cigarette production by 12% over the next 15 years. PMI and Bat have successfully entered and are expanding their share in the Indonesia cigarette market. Despite the obvious and pervasive influence of the tobacco industry on policy decisions, the Indonesian government should ratify the FCTC and implement effective legislation to reduce tobacco consumption and exposure to tobacco smoke and revise the Roadmap to protect future generations of Indonesians.

Roadmap to a Tobacco Epidemic: Transnational Tobacco Companies Invade Indonesia

PubMed Central

Hurt, Richard D.; Ebbert, Jon O.; Achadi, Anhari; Croghan, Ivana T.

2014-01-01

Background Indonesia is the world’s fifth largest cigarette market in the world but for decades, transnational tobacco companies (TTCs) have had limited success infiltrating this market, due to their inability to compete in the kretek market. Kreteks are clove/tobacco cigarettes that most Indonesians smoke. Objective To determine how Phillip Morris International (PMI) and British American Tobacco (BAT) have now successfully achieved a substantial market presence in Indonesia. Methods We analyzed previously secret, tobacco industry documents, corporate reports on Indonesia operations, the Tobacco Trade press, Indonesia media, and “The Roadmap.” Results Internal, corporate documents from BAT and PMI demonstrate that they had known for decades that kreteks are highly carcinogenic. Despite that knowledge, BAT and PMI now own and heavily market these products, as well as new more westernized versions of kreteks. BAT and PMI maintained the basic strategy of keeping cigarettes affordable by maintaining the social responsibility of smoking and opposing smoke-free workplace laws but in the 21st century, they added the acquisition of and Westernization of domestic kretek manufacturers as an additional strategy. These acquisitions allowed them to assert influences on health policy in Indonesia and to grow their business under current government policy embodied in the 2007-2020 Roadmap of Tobacco Products Industry and Excise Policy which calls for increased cigarette production by 12% over the next 15 years. Conclusion PMI and Bat have successfully entered and are expanding their share in the Indonesia cigarette market. Despite the obvious and pervasive influence of the tobacco industry on policy decisions, the Indonesian government should ratify the FCTC and implement effective legislation to reduce tobacco consumption and exposure to tobacco smoke and revise the Roadmap to protect future generations of Indonesians. PMID:21852413

Idaho National Engineering Laboratory High-Level Waste Roadmap. Revision 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1993-08-01

The Idaho National Engineering Laboratory (INEL) High-Level Waste (HLW) Roadmap takes a strategic look at the entire HLW life-cycle starting with generation, through interim storage, treatment and processing, transportation, and on to final disposal. The roadmap is an issue-based planning approach that compares ``where we are now`` to ``where we want and need to be.`` The INEL has been effectively managing HLW for the last 30 years. Calcining operations are continuing to turn liquid HLW into a more manageable form. Although this document recognizes problems concerning HLW at the INEL, there is no imminent risk to the public or environment.more » By analyzing the INEL current business operations, pertinent laws and regulations, and committed milestones, the INEL HLW Roadmap has identified eight key issues existing at the INEL that must be resolved in order to reach long-term objectives. These issues are as follows: A. The US Department of Energy (DOE) needs a consistent policy for HLW generation, handling, treatment, storage, and disposal. B. The capability for final disposal of HLW does not exist. C. Adequate processes have not been developed or implemented for immobilization and disposal of INEL HLW. D. HLW storage at the INEL is not adequate in terms of capacity and regulatory requirements. E. Waste streams are generated with limited consideration for waste minimization. F. HLW is not adequately characterized for disposal nor, in some cases, for storage. G. Research and development of all process options for INEL HLW treatment and disposal are not being adequately pursued due to resource limitations. H. HLW transportation methods are not selected or implemented. A root-cause analysis uncovered the underlying causes of each of these issues.« less

Enhanced ergonomics approaches for product design: a user experience ecosystem perspective and case studies.

PubMed

Xu, Wei

2014-01-01

This paper first discusses the major inefficiencies faced in current human factors and ergonomics (HFE) approaches: (1) delivering an optimal end-to-end user experience (UX) to users of a solution across its solution lifecycle stages; (2) strategically influencing the product business and technology capability roadmaps from a UX perspective and (3) proactively identifying new market opportunities and influencing the platform architecture capabilities on which the UX of end products relies. In response to these challenges, three case studies are presented to demonstrate how enhanced ergonomics design approaches have effectively addressed the challenges faced in current HFE approaches. Then, the enhanced ergonomics design approaches are conceptualised by a user-experience ecosystem (UXE) framework, from a UX ecosystem perspective. Finally, evidence supporting the UXE, the advantage and the formalised process for executing UXE and methodological considerations are discussed. Practitioner Summary: This paper presents enhanced ergonomics approaches to product design via three case studies to effectively address current HFE challenges by leveraging a systematic end-to-end UX approach, UX roadmaps and emerging UX associated with prioritised user needs and usages. Thus, HFE professionals can be more strategic, creative and influential.

A Systematic Review of Risk Factors Prospectively Associated with Borderline Personality Disorder: Taking Stock and Moving Forward

PubMed Central

Stepp, Stephanie D.; Lazarus, Sophie A.; Byrd, Amy L.

2016-01-01

There is an urgent need to identify signs that harbinger onset of borderline personality disorder (BPD). Advancement in this area is required to refine developmental theories, discover etiological mechanisms, improve early detection, and achieve our ultimate goal of prevention. Though many studies have supported a wide range of factors that increase subsequent risk for BPD, this literature has yet to be critically evaluated, and there are no comprehensive reviews that examine and integrate these findings. To address this limitation, we conducted a systematic review to summarize and synthesize the current literature. Electronic databases were systematically searched for prospective, longitudinal studies that examined risk factors of subsequent BPD outcomes (features, symptoms, diagnosis) resulting in a total of 39 studies, reflecting 24 unique samples. Though increased risk for BPD was reliably attributed to multiple factors within social, family, maltreatment, and child domains, the most striking limitation of this research is its lack of disorder-specific findings Additional limitations, including notable heterogeneity in sampling methodology, symptom assessment methodology, and developmental timing of assessments, are discussed in terms of how close are we to pinpointing who is most at risk and why in an attempt to provide a roadmap for future research. PMID:27709988

A systematic review of risk factors prospectively associated with borderline personality disorder: Taking stock and moving forward.

PubMed

Stepp, Stephanie D; Lazarus, Sophie A; Byrd, Amy L

2016-10-01

There is an urgent need to identify signs that harbinger onset of borderline personality disorder (BPD). Advancement in this area is required to refine developmental theories, discover etiological mechanisms, improve early detection, and achieve our ultimate goal of prevention. Though many studies have supported a wide range of factors that increase subsequent risk for BPD, this literature has yet to be critically evaluated, and there are no comprehensive reviews that examine and integrate these findings. To address this limitation, we conducted a systematic review to summarize and synthesize the current literature. Electronic databases were systematically searched for prospective, longitudinal studies that examined risk factors of subsequent BPD outcomes (features, symptoms, diagnosis), resulting in a total of 39 studies, reflecting 24 unique samples. Though increased risk for BPD was reliably attributed to multiple factors within social, family, maltreatment, and child domains, the most striking limitation of this research is its lack of disorder-specific findings. Additional limitations, including notable heterogeneity in sampling methodology, symptom assessment methodology, and developmental timing of assessments, are discussed in terms of how close we are to pinpointing who is most at risk and why in an attempt to provide a roadmap for future research. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

International Dengue Vaccine Communication and Advocacy: Challenges and Way Forward.

PubMed

Carvalho, Ana; Van Roy, Rebecca; Andrus, Jon

2016-01-01

Dengue vaccine introduction will likely occur soon. However, little has been published on international dengue vaccine communication and advocacy. More effort at the international level is required to review, unify and strategically disseminate dengue vaccine knowledge to endemic countries' decision makers and potential donors. Waiting to plan for the introduction of new vaccines until licensure may delay access in developing countries. Concerted efforts to communicate and advocate for vaccines prior to licensure are likely challenged by unknowns of the use of dengue vaccines and the disease, including uncertainties of vaccine impact, vaccine access and dengue's complex pathogenesis and epidemiology. Nevertheless, the international community has the opportunity to apply previous best practices for vaccine communication and advocacy. The following key strategies will strengthen international dengue vaccine communication and advocacy: consolidating existing coalitions under one strategic umbrella, urgently convening stakeholders to formulate the roadmap for integrated dengue prevention and control, and improving the dissemination of dengue scientific knowledge.

Genotyping for Severe Drug Hypersensitivity

PubMed Central

Karlin, Eric; Phillips, Elizabeth

2014-01-01

Over the past decade, there have been significant advances in our understanding of the immunopathogenesis and pharmacogenomics of severe immunologically-mediated adverse drug reactions. Such T-cell-mediated adverse drug reactions such as Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), drug-induced liver disease (DILI) and other drug hypersensitivity syndromes have more recently been shown to be mediated through interactions with various class I and II HLA alleles. Key examples have included the associations of HLA-B*15:02 and carbamazepine induced SJS/TEN in Southeast Asian populations and HLA-B*57:01 and abacavir hypersensitivity. HLA-B*57:01 screening to prevent abacavir hypersensitivity exemplifies a successful translational roadmap from pharmacogenomic discovery through to widespread clinical implementation. Ultimately, our increased understanding of the interaction between drugs and the MHC could be used to inform drug design and drive pre-clinical toxicity programs to improve drug safety. PMID:24429903

Back pain in space and post-flight spine injury: Mechanisms and countermeasure development

NASA Astrophysics Data System (ADS)

Sayson, Jojo V.; Lotz, Jeffrey; Parazynski, Scott; Hargens, Alan R.

2013-05-01

During spaceflight many astronauts experience moderate to severe lumbar pain and deconditioning of paraspinal muscles. There is also a significant incidence of herniated nucleus pulposus (HNP) in astronauts post-flight being most prevalent in cervical discs. Relief of in-flight lumbar back pain is facilitated by assuming a knee-to-chest position. The pathogenesis of lumbar back pain during spaceflight is most likely discogenic and somatic referred (from the sinuvertebral nerves) due to supra-physiologic swelling of the lumbar intervertebral discs (IVDs) due to removal of gravitational compressive loads in microgravity. The knee-to-chest position may reduce lumbar back pain by redistributing stresses through compressive loading to the IVDs, possibly reducing disc volume by fluid outflow across IVD endplates. IVD stress redistribution may reduce Type IV mechanoreceptor nerve impulse propagation in the annulus fibrosus and vertebral endplate resulting in centrally mediated pain inhibition during spinal flexion. Countermeasures for lumbar back pain may include in-flight use of: (1) an axial compression harness to prevent excessive IVD expansion and spinal column elongation; (2) the use of an adjustable pulley exercise developed to prevent atrophy of spine muscle stabilisers; and (3) other exercises that provide Earth-like annular stress with low-load repetitive active spine rotation movements. The overall objective of these countermeasures is to promote IVD health and to prevent degenerative changes that may lead to HNPs post-flight. In response to "NASA's Critical Path Roadmap Risks and Questions" regarding disc injury and higher incidence of HNPs after space flight (Integrated Research Plan Gap-B4), future studies will incorporate pre- and post-flight imaging of International Space Station long-duration crew members to investigate mechanisms of lumbar back pain as well as degeneration and damage to spinal structures. Quantitative results on morphological, biochemical, metabolic, and kinematic spinal changes in the lumbar spine may aid further development of countermeasures to prevent lumbar back pain in microgravity and reduce the incidence of HNPs post-flight.

Count every newborn; a measurement improvement roadmap for coverage data

PubMed Central

2015-01-01

Background The Every Newborn Action Plan (ENAP), launched in 2014, aims to end preventable newborn deaths and stillbirths, with national targets of ≤12 neonatal deaths per 1000 live births and ≤12 stillbirths per 1000 total births by 2030. This requires ambitious improvement of the data on care at birth and of small and sick newborns, particularly to track coverage, quality and equity. Methods In a multistage process, a matrix of 70 indicators were assessed by the Every Newborn steering group. Indicators were graded based on their availability and importance to ENAP, resulting in 10 core and 10 additional indicators. A consultation process was undertaken to assess the status of each ENAP core indicator definition, data availability and measurement feasibility. Coverage indicators for the specific ENAP treatment interventions were assigned task teams and given priority as they were identified as requiring the most technical work. Consultations were held throughout. Results ENAP published 10 core indicators plus 10 additional indicators. Three core impact indicators (neonatal mortality rate, maternal mortality ratio, stillbirth rate) are well defined, with future efforts needed to focus on improving data quantity and quality. Three core indicators on coverage of care for all mothers and newborns (intrapartum/skilled birth attendance, early postnatal care, essential newborn care) have defined contact points, but gaps exist in measuring content and quality of the interventions. Four core (antenatal corticosteroids, neonatal resuscitation, treatment of serious neonatal infections, kangaroo mother care) and one additional coverage indicator for newborns at risk or with complications (chlorhexidine cord cleansing) lack indicator definitions or data, especially for denominators (population in need). To address these gaps, feasible coverage indicator definitions are presented for validity testing. Measurable process indicators to help monitor health service readiness are also presented. A major measurement gap exists to monitor care of small and sick babies, yet signal functions could be tracked similarly to emergency obstetric care. Conclusions The ENAP Measurement Improvement Roadmap (2015-2020) outlines tools to be developed (e.g., improved birth and death registration, audit, and minimum perinatal dataset) and actions to test, validate and institutionalise proposed coverage indicators. The roadmap presents a unique opportunity to strengthen routine health information systems, crosslinking these data with civil registration and vital statistics and population-based surveys. Real measurement change requires intentional transfer of leadership to countries with the greatest disease burden and will be achieved by working with centres of excellence and existing networks. PMID:26391444

Roadmap of Federal Reserve Resources for Teaching Economics and Personal Finance

ERIC Educational Resources Information Center

Messina, Sara; Hennessy, Amy; Rossiter, Caryn

2011-01-01

Many textbooks define economics as the social science that studies how people make choices when faced with scarcity; or how a society decides what to produce, how to produce, and for whom to produce. Regardless of the definition, students' economic understanding is fundamental to their financial well-being and their ability to build successful…

Continuous Quality Improvement: A Roadmap for Rural School Improvement.

ERIC Educational Resources Information Center

Kilmer, Lloyd C.

A case study documented a continuous quality improvement approach to school improvement in a rural Nebraska high school over a 2-year period. Data gathered from surveys, portfolios, pilot results, and test scores indicated that the changes during the 2-year period were not dramatic, but significant and consistent with the Total Quality literature.…

75 FR 3956 - Intent To Prepare an Environmental Impact Statement for Proposed Transit Improvements in the...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-25

... purpose and need, the alternatives to be studied, the impacts to be evaluated, and the evaluation methods... clear roadmap for concise development of the environmental document. In the interest of producing a... unincorporated Los Angeles County which includes east Los Angeles and west Whittier-Los Nietos. A diverse mix of...

Toward a Sustainable Society in the Mena (Middle East and North Africa) Region: Roadmap and Priorities

ERIC Educational Resources Information Center

El-Bassiouny, Noha

2012-01-01

The Business and Society Research Cluster (BSRC) at the German University in Cairo, the El-Khazindar Business Research and Case Center at the American University in Cairo and Misr El-Kheir (MEK) Foundation, Egypt, hosted the region's first sustainability and corporate social responsibility (CSR) case studies conference, entitled "Toward a…

Iran diabetes research roadmap (IDRR) study: a preliminary study on diabetes research in the world and Iran.

PubMed

Nasli-Esfahani, Ensieh; Farzadfar, Farshad; Kouhnavard, Marjan; Ghodssi-Ghassemabadi, Robabeh; Khajavi, Alireza; Peimani, Maryam; Razmandeh, Rezvan; Vala, Mahboobeh; Shafiee, Gita; Rambod, Camelia; Sanjari, Mahnaz; Aalaa, Maryam; Ghodsi, Maryam; Razi, Farideh; Bandarian, Fatemeh; Larijani, Bagher

2017-01-01

Diabetes is one of the most common metabolic disorders worldwide. This study aim was to provide detail analysis of diabetes research output and its trend in Iran as well as in the world and compare them. Data was retrieved from PubMed database using a suitable search strategy and application of proper operator "AND", "OR" and "NOT". All English documents published from 2008 to 2012 were included. Meeting abstract, letter to the editor, guidelines, consensus and reviews were excluded. Obtained documents for Iran and world were categorized in eleven groups including diabetes management, education, paediatrics, nutrition, epidemiology, diabetes complications, stem cells, gestational diabetes mellitus (GDM), psychiatrics, genetics and prevention and were compared. Total number of DM publications was 59513 for world and 648 for Iran. Trend of DM publications was increasing during the 5 years with a growth rate of 22.5% for world and 23.4% for Iran. Contribution of Iran in the world diabetes output reached 1.08 in 2012. The most and the least number of DM documents were related to complications and preventions, respectively both in Iran and the world. Three leading countries with highest proportion of RCTs (randomized clinical trial) to their total DM publications were Italy, Germany and Iran. The most number of diabetes research was in the field of diabetes complication, management and genetics in the world as well as in Iran. During the 5-year period, despite of the world sanctions against Iran, diabetes research trend was increasing in Iran relatively parallel to the world research and sanction had no significant effect on Iran.

Convergent innovation for affordable nutrition, health, and health care: the global pulse roadmap.

PubMed

Jha, Srivardhini K; McDermott, John; Bacon, Gordon; Lannon, Chris; Joshi, P K; Dubé, Laurette

2014-12-01

The paper outlines how the principles of convergent innovation (CI) can be applied to bring about a transformation in the pulse value chain. The paper presents three pioneering CI initiatives--two in conception and one in operation--by various actors in the pulse ecosystem, which are delivering economic and human development impact in particular segments of the pulse value chain. It goes on to propose the way forward to scale up these efforts and connect them into a roadmap so as to achieve transformation throughout society, calling into action a number of actors in the ecosystem. © 2014 New York Academy of Sciences.

Roadmap to a Sustainable Structured Trusted Employee Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coates, Cameron W; Eisele, Gerhard R

2013-08-01

Organizations (facility, regulatory agency, or country) have a compelling interest in ensuring that individuals who occupy sensitive positions affording access to chemical biological, radiological and nuclear (CBRN) materials facilities and programs are functioning at their highest level of reliability. Human reliability and human performance relate not only to security but also focus on safety. Reliability has a logical and direct relationship to trustworthiness for the organization is placing trust in their employees to conduct themselves in a secure, safe, and dependable manner. This document focuses on providing an organization with a roadmap to implementing a successful and sustainable Structured Trustedmore » Employee Program (STEP).« less

Community resources and technologies developed through the NIH Roadmap Epigenomics Program.

PubMed

Satterlee, John S; Beckel-Mitchener, Andrea; McAllister, Kim; Procaccini, Dena C; Rutter, Joni L; Tyson, Frederick L; Chadwick, Lisa Helbling

2015-01-01

This chapter describes resources and technologies generated by the NIH Roadmap Epigenomics Program that may be useful to epigenomics researchers investigating a variety of diseases including cancer. Highlights include reference epigenome maps for a wide variety of human cells and tissues, the development of new technologies for epigenetic assays and imaging, the identification of novel epigenetic modifications, and an improved understanding of the role of epigenetic processes in a diversity of human diseases. We also discuss future needs in this area including exploration of epigenomic variation between individuals, single-cell epigenomics, environmental epigenomics, exploration of the use of surrogate tissues, and improved technologies for epigenome manipulation.

Roadmap to risk evaluation and mitigation strategies (REMS) success

PubMed Central

Balian, John D.; Malhotra, Rachpal; Perentesis, Valerie

2010-01-01

Medical safety-related risk management is a rapidly evolving and increasingly important aspect of drug approval and market longevity. To effectively meet the challenges of this new era, we describe a risk management roadmap that proactively yet practically anticipates risk-management requirements, provides the foundation for enduring yet appropriately flexible risk-management practices, and leverages these techniques to efficiently and effectively utilize risk evaluation and mitigation strategies (REMS)/risk minimization programs as market access enablers. This fully integrated risk-management paradigm creates exciting opportunities for newer tools, techniques, and approaches to more successfully optimize product development, approval, and commercialization, with patients as the ultimate beneficiaries. PMID:25083193

Roadmaps to Transition Countries to 100% Clean, Renewable Energy for All Purposes to Curtail Global Warming, Air Pollution, and Energy Risk

NASA Astrophysics Data System (ADS)

Jacobson, Mark Z.

2017-10-01

Solving the problems of global warming, air pollution, and energy security requires a massive effort by individuals, communities, businesses, nonprofits, and policy makers around the world. The first step in that process is to have a plan. To that end, roadmaps to transition 139 countries of the world to 100% clean, renewable wind, water, and solar power for all energy purposes (electricity, transportation, heating, cooling, industry, agriculture, forestry, and fishing) by 2050, with 80% by 2030, have been developed. The evolution, characteristics, and impacts to date of these plans are briefly described.

Integrity and security in an Ada runtime environment

NASA Technical Reports Server (NTRS)

Bown, Rodney L.

1991-01-01

A review is provided of the Formal Methods group discussions. It was stated that integrity is not a pure mathematical dual of security. The input data is part of the integrity domain. The group provided a roadmap for research. One item of the roadmap and the final position statement are closely related to the space shuttle and space station. The group's position is to use a safe subset of Ada. Examples of safe sets include the Army Secure Operating System and the Penelope Ada verification tool. It is recommended that a conservative attitude is required when writing Ada code for life and property critical systems.

A Roadmap for Educational Research in Pharmacy

PubMed Central

Dean, Meredith J.; Mumper, Russell J.; Blouin, Robert A.; Roth, Mary T.

2013-01-01

Educational research must play a critical role in informing practice and policy within pharmacy education. Understanding the educational environment and its impact on students, faculty members, and other stakeholders is imperative for improving outcomes and preparing pharmacy students to meet the needs of 21st century health care. To aid in the design and implementation of meaningful educational research within colleges and schools of pharmacy, this roadmap addresses philosophy and educational language; guidelines for the conduct of educational research; research design, including 4 approaches to defining, collecting, and analyzing educational data; measurement issues; ethical considerations; resources and tools; and the value of educational research in guiding curricular transformation. PMID:24371342

HTA Implementation Roadmap in Central and Eastern European Countries

PubMed Central

Gheorghe, Adrian; Huic, Mirjana; Csanádi, Marcell; Kristensen, Finn Boerlum

2016-01-01

Abstract The opportunity cost of inappropriate health policy decisions is greater in Central and Eastern European (CEE) compared with Western European (WE) countries because of poorer population health and more limited healthcare resources. Application of health technology assessment (HTA) prior to healthcare financing decisions can improve the allocative efficiency of scarce resources. However, few CEE countries have a clear roadmap for HTA implementation. Examples from high‐income countries may not be directly relevant, as CEE countries cannot allocate so much financial and human resources for substantiating policy decisions with evidence. Our objective was to describe the main HTA implementation scenarios in CEE countries and summarize the most important questions related to capacity building, financing HTA research, process and organizational structure for HTA, standardization of HTA methodology, use of local data, scope of mandatory HTA, decision criteria, and international collaboration in HTA. Although HTA implementation strategies from the region can be relevant examples for other CEE countries with similar cultural environment and economic status, HTA roadmaps are not still fully transferable without taking into account country‐specific aspects, such as country size, gross domestic product per capita, major social values, public health priorities, and fragmentation of healthcare financing. Copyright © 2016 John Wiley & Sons, Ltd. PMID:26763688

The Global Exploration Roadmap and its significance for NASA

NASA Astrophysics Data System (ADS)

Laurini, K. C.; Gerstenmaier, W. H.

2014-08-01

The Global Exploration Roadmap reflects the collaborative effort of twelve space agencies to define a long-term human space exploration strategy which provides substantial benefits for improving the quality of life on Earth and is implementable and sustainable. Such a strategy is a necessary precondition to the government investments required to enable the challenging and rewarding missions that extend human presence into the solar system. The article introduces the international strategy and elaborates on NASA's leadership role in shaping that strategy. The publication of the roadmap, a reflection of the space landscape and multilateral agency-level dialog over the last four years, allows NASA to demonstrate its commitment to leading a long-term space exploration endeavor that delivers benefits, maintains strategic human spaceflight capabilities and expands human presence in space, with human missions to the surface of Mars as a driving goal. The road mapping process has clearly demonstrated the complementary interests of the participants and the potential benefits that can be gained through cooperation among nations to achieve a common goal. The present US human spaceflight policy is examined and it is shown that the establishment of a sustainable global space exploration strategy is fully consistent with that policy.

MaRIE theory, modeling and computation roadmap executive summary

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lookman, Turab

The confluence of MaRIE (Matter-Radiation Interactions in Extreme) and extreme (exascale) computing timelines offers a unique opportunity in co-designing the elements of materials discovery, with theory and high performance computing, itself co-designed by constrained optimization of hardware and software, and experiments. MaRIE's theory, modeling, and computation (TMC) roadmap efforts have paralleled 'MaRIE First Experiments' science activities in the areas of materials dynamics, irradiated materials and complex functional materials in extreme conditions. The documents that follow this executive summary describe in detail for each of these areas the current state of the art, the gaps that exist and the road mapmore » to MaRIE and beyond. Here we integrate the various elements to articulate an overarching theme related to the role and consequences of heterogeneities which manifest as competing states in a complex energy landscape. MaRIE experiments will locate, measure and follow the dynamical evolution of these heterogeneities. Our TMC vision spans the various pillar science and highlights the key theoretical and experimental challenges. We also present a theory, modeling and computation roadmap of the path to and beyond MaRIE in each of the science areas.« less

Risk assessment in the 21st century: roadmap and matrix.

PubMed

Embry, Michelle R; Bachman, Ammie N; Bell, David R; Boobis, Alan R; Cohen, Samuel M; Dellarco, Michael; Dewhurst, Ian C; Doerrer, Nancy G; Hines, Ronald N; Moretto, Angelo; Pastoor, Timothy P; Phillips, Richard D; Rowlands, J Craig; Tanir, Jennifer Y; Wolf, Douglas C; Doe, John E

2014-08-01

Abstract The RISK21 integrated evaluation strategy is a problem formulation-based exposure-driven risk assessment roadmap that takes advantage of existing information to graphically represent the intersection of exposure and toxicity data on a highly visual matrix. This paper describes in detail the process for using the roadmap and matrix. The purpose of this methodology is to optimize the use of prior information and testing resources (animals, time, facilities, and personnel) to efficiently and transparently reach a risk and/or safety determination. Based on the particular problem, exposure and toxicity data should have sufficient precision to make such a decision. Estimates of exposure and toxicity, bounded by variability and/or uncertainty, are plotted on the X- and Y-axes of the RISK21 matrix, respectively. The resulting intersection is a highly visual representation of estimated risk. Decisions can then be made to increase precision in the exposure or toxicity estimates or declare that the available information is sufficient. RISK21 represents a step forward in the goal to introduce new methodologies into 21st century risk assessment. Indeed, because of its transparent and visual process, RISK21 has the potential to widen the scope of risk communication beyond those with technical expertise.

A Vision and Roadmap for Increasing User Autonomy in Flight Operations in the National Airspace

NASA Technical Reports Server (NTRS)

Cotton, William B.; Hilb, Robert; Koczo, Stefan; Wing, David

2016-01-01

The purpose of Air Transportation is to move people and cargo safely, efficiently and swiftly to their destinations. The companies and individuals who use aircraft for this purpose, the airspace users, desire to operate their aircraft according to a dynamically optimized business trajectory for their specific mission and operational business model. In current operations, the dynamic optimization of business trajectories is limited by constraints built into operations in the National Airspace System (NAS) for reasons of safety and operational needs of the air navigation service providers. NASA has been developing and testing means to overcome many of these constraints and permit operations to be conducted closer to the airspace user's changing business trajectory as conditions unfold before and during the flight. A roadmap of logical steps progressing toward increased user autonomy is proposed, beginning with NASA's Traffic Aware Strategic Aircrew Requests (TASAR) concept that enables flight crews to make informed, deconflicted flight-optimization requests to air traffic control. These steps include the use of data communications for route change requests and approvals, integration with time-based arrival flow management processes under development by the Federal Aviation Administration (FAA), increased user authority for defining and modifying downstream, strategic portions of the trajectory, and ultimately application of self-separation. This progression takes advantage of existing FAA NextGen programs and RTCA standards development, and it is designed to minimize the number of hardware upgrades required of airspace users to take advantage of these advanced capabilities to achieve dynamically optimized business trajectories in NAS operations. The roadmap is designed to provide operational benefits to first adopters so that investment decisions do not depend upon a large segment of the user community becoming equipped before benefits can be realized. The issues of equipment certification and operational approval of new procedures are addressed in a way that minimizes their impact on the transition by deferring a change in the assignment of separation responsibility until a large body of operational data is available to support the safety case for this change in the last roadmap step.This paper will relate the roadmap steps to ongoing activities to clarify the economics-based transition to these technologies for operational use.

User-centered Design Groups to Engage Patients and Caregivers with a Personalized Health IT Tool

PubMed Central

Maher, Molly; Kaziunas, Elizabeth; Ackerman, Mark; Derry, Holly; Forringer, Rachel; Miller, Kristen; O’Reilly, Dennis; An, Larry C.; Tewari, Muneesh; Hanauer, David A.; Choi, Sung Won

2015-01-01

Health information technology (IT) has opened exciting avenues for capturing, delivering and sharing data, and offers the potential to develop cost-effective, patient-focused applications. In recent years, there has been a proliferation of health IT applications such as outpatient portals. Rigorous evaluation is fundamental to ensure effectiveness and sustainability, as resistance to more widespread adoption of outpatient portals may be due to lack of user friendliness. Health IT applications that integrate with the existing electronic health record and present information in a condensed, user-friendly format could improve coordination of care and communication. Importantly, these applications should be developed systematically with appropriate methodological design and testing to ensure usefulness, adoption, and sustainability. Based on our prior work that identified numerous information needs and challenges of HCT, we developed an experimental prototype of a health IT tool, the BMT Roadmap. Our goal was to develop a tool that could be used in the real-world, daily practice of HCT patients and caregivers (users) in the inpatient setting. In the current study, we examined the views, needs, and wants of patients and caregivers in the design and development process of the BMT Roadmap through two user-centered Design Groups, conducted in March 2015 and April 2015, respectively: Design Group I utilized a low-fidelity paper-based prototype and Design Group II utilized a high-fidelity prototype presented to users as a web-app on Apple® iPads. There were 11 caregivers (median age 44, range 34–69 years) and 8 patients (median age 18 years, range 11–24 years) in the study population. The qualitative analyses revealed a wide range of responses helpful in guiding the iterative development of the system. Three important themes emerged from the Design Groups: 1) perception of core features as beneficial (views), 2) alerting the design team to potential issues with the user interface (needs); and 3) providing a deeper understanding of the user experience in terms of wider psychosocial requirements (wants). From the patient and caregiver perspectives, the BMT Roadmap system was considered useful. The findings from the Design Groups resulted in changes that led to an improved, functional BMT Roadmap product. This unique research process and the findings reported herein included data generated from patients, caregivers, providers, and researchers as partners. Collectively, the data informed the design and development of the tool, which will be tested as an intervention in the pediatric HCT population at our center in the fall of 2015 (ClinicalTrials.gov NCT02409121). PMID:26343948

Feasibility study for a survey measuring abuse and neglect of older adults.

PubMed

Mayda, Jacqueline; Magnus, Bill; Duggan, Joseph; Taylor-Butts, Andrea

2012-04-01

This feasibility study was prepared by Statistics Canada, under arrangement with the Strategic Policy Research Directorate, Human Resources and Skills Development Canada (HRSDC). It investigates issues associated with conducting surveys of abuse and neglect of older adults in community and institutional settings in Canada. A roadmap is provided for the work ahead, including options for a sampling frame, collection approaches, estimated costs, and an activity schedule.

A Governance Roadmap and Framework for EarthCube

NASA Astrophysics Data System (ADS)

Allison, M. L.

2012-12-01

EarthCube is a process and an outcome, established to transform the conduct of research through the development of community-guided cyberinfrastructure for the Geosciences as the prototype for potential deployment across all domain sciences. EarthCube aims to create a knowledge management system and infrastructure that integrates all Earth system and human dimensions data in an open transparent, and inclusive manner. EarthCube requires broad community participation in concept, framework, and implementation and must not be hindered by rigid preconceptions. We discovered widely varying interpretations, expectations, and assumptions about governance among EarthCube participants. Our definition of governance refers to the processes, structure and organizational elements that determine, within an organization or system of organizations, how power is exercised, how stakeholders have their say, how decisions are made, and how decision makers are held accountable. We have learned, from historic infrastructure case studies, background research on governance and from community feedback during this roadmap process, that other types of large-scale, complex infrastructures, including the Internet, have no central control, administration, or management. No national infrastructure that we examined is governed by a single entity, let alone a single governance archetype. Thus we feel the roadmap process must accommodate a governance system or system of systems that may have a single governing entity, particularly at the start, but can evolve into a collective of governing bodies as warranted, in order to be successful. A fast-track process during Spring, 2012 culminated in a Governance Roadmap delivered to an NSF-sponsored charrette in June with an aggressive timetable to define and implement a governance structure to enable the elements of EarthCube to become operational expeditiously. Our goal is to help ensure the realization of this infrastructure sooner, more efficiently, and more effectively, by providing a community endorsed Governance Framework. The Framework, and corresponding community outreach, will maximize engagement of the broader EarthCube community, which in turn will minimize the risks that the community will not adopt EarthCube in its development and final states. The target community includes academia, government, and the private-sector, both nationally and internationally. Based on community feedback to-date, we compiled and synthesized system-wide governance requirements to draft an initial set of EarthCube Governance functions. These functions will permit us to produce a Governance Framework based on an aggressive community outreach and engagement plan.

Evaluation of cardiovascular risks of spaceflight does not support the NASA bioastronautics critical path roadmap.

PubMed

Convertino, Victor A; Cooke, William H

2005-09-01

Occurrence of serious cardiac dysrhythmias and diminished cardiac and vascular function are the primary cardiovascular risks of spaceflight identified in the 2005 NASA Bioastronautics Critical Path Roadmap. A review of the literature was conducted on experimental results and observational data obtained from spaceflight and relevant ground simulation studies that addressed occurrence of cardiac dysrhythmias, cardiac contractile and vascular function, manifestation of asymptomatic cardiovascular disease, orthostatic intolerance, and response to exercise stress. Based on data from astronauts who have flown in space, there is no compelling experimental evidence to support significant occurrence of cardiac dysrhythmias, manifestation of asymptomatic cardiovascular disease, or reduction in myocardial contractile function. Although there are post-spaceflight data that demonstrate lower peripheral resistance in astronauts who become presyncopal compared with non-presyncopal astronauts, it is not clear that these differences are the result of decreased vascular function. However, the evidence of postflight orthostatic intolerance and reduced exercise capacity is well substantiated by both spaceflight and ground experiments. Although attenuation of baroreflex function(s) may contribute to postflight orthostatic instability, a primary mechanism of orthostatic intolerance and reduced exercise capacity is reduced end-diastolic and stroke volume associated with lower blood volumes and consequent cardiac remodeling. Data from the literature on the current population of astronauts support the notion that the primary cardiovascular risks of spaceflight are compromised hemodynamic responses to central hypovolemia resulting in reduced orthostatic tolerance and exercise capacity rather than occurrence of cardiac dysrhythmias, reduced cardiac contractile and vascular function, or manifestation of asymptomatic cardiovascular disease. These observations warrant a critical review and revision of the 2005 Bioastronautics Critical Path Roadmap.

NASA Propulsion Sub-System Concept Studies and Risk Reduction Activities for Resource Prospector Lander

NASA Technical Reports Server (NTRS)

Trinh, Huu P.

2015-01-01

NASA's exploration roadmap is focused on developing technologies and performing precursor missions to advance the state of the art for eventual human missions to Mars. One of the key components of this roadmap is various robotic missions to Near-Earth Objects, the Moon, and Mars to fill in some of the strategic knowledge gaps. The Resource Prospector (RP) project is one of these robotic precursor activities in the roadmap. RP is a multi-center and multi-institution project to investigate the polar regions of the Moon in search of volatiles. The mission is rated Class D and is approximately 10 days, assuming a five day direct Earth to Moon transfer. Because of the mission cost constraint, a trade study of the propulsion concepts was conducted with a focus on available low-cost hardware for reducing cost in development, while technical risk, system mass, and technology advancement requirements were also taken into consideration. The propulsion system for the lander is composed of a braking stage providing a high thrust to match the lander's velocity with the lunar surface and a lander stage performing the final lunar descent. For the braking stage, liquid oxygen (LOX) and liquid methane (LCH4) propulsion systems, derived from the Morpheus experimental lander, and storable bi-propellant systems, including the 4th stage Peacekeeper (PK) propulsion components and Space Shuttle orbital maneuvering engine (OME), and a solid motor were considered for the study. For the lander stage, the trade study included miniaturized Divert Attitude Control System (DACS) thrusters (Missile Defense Agency (MDA) heritage), their enhanced thruster versions, ISE-100 and ISE-5, and commercial-off-the-shelf (COTS) hardware. The lowest cost configuration of using the solid motor and the PK components while meeting the requirements was selected. The reference concept of the lander is shown in Figure 1. In the current reference configuration, the solid stage is the primary provider of delta-V. It will generate 15,000-lbf of thrust with a single burn of 80's seconds. The lander stage is a bi-propellant, pressure-regulated, pulsing liquid propulsion system to perform all other functions.

Seeking a Roadmap to Becoming World Class: Strategic Planning at Peking University. Research & Occasional Paper Series: CSHE.11.13

ERIC Educational Resources Information Center

Guangkuan, Xie

2013-01-01

Strategic planning plays an important but sometimes controversial role in higher education. This paper examines how strategic planning works in Chinese universities, using Peking University as a case study. This essay discusses the rationale for why Peking University (PKU) decided to pursue status as a world-class university along with objectives…

Senior University Officials' Approaches to Global Engagement: A Case Study of a Private and a Public Research University

ERIC Educational Resources Information Center

Chan, Shirley

2013-01-01

The phenomenon of globalization has a significant impact on higher education, but the lack of a clear roadmap for how senior university officials should create and implement global engagement strategies and for how these approaches support (or impede) an organizational culture that fosters globalization remains a gap in knowledge in higher…

Vanderbilt University Study Creates New Roadmap for Cellular Activity | Office of Cancer Clinical Proteomics Research

Cancer.gov

Human cells are constructed in large part from proteins whose activity can be altered by the incorporation of oxygen in what are known as redox modifications. Jing Yang, Ph.D., and colleagues are working to identify oxygen modifications at the cellular level that can create a pathway to certain diseases. (photo by Susan Urmy)

Credit-by-Exam Acceptance Policies: Advanced Study of Washington State's Public Colleges and Universities

ERIC Educational Resources Information Center

Burke, Rachel; Martin, Gloria

2014-01-01

Washington Student Achievement Council's 10-Year Roadmap sets a goal for 2023 of having 70 percent of Washington adults (ages 25-44) receive a postsecondary credential. At the same time, dramatic cuts in state funding for higher education, particularly since 2008, have shifted more of the cost of higher education onto students and families, making…

Rationale and Roadmap for Moon Exploration

NASA Astrophysics Data System (ADS)

Foing, B. H.; ILEWG Team

We discuss the different rationale for Moon exploration. This starts with areas of scientific investigations: clues on the formation and evolution of rocky planets, accretion and bombardment in the inner solar system, comparative planetology processes (tectonic, volcanic, impact cratering, volatile delivery), records astrobiology, survival of organics; past, present and future life. The rationale includes also the advancement of instrumentation: Remote sensing miniaturised instruments; Surface geophysical and geochemistry package; Instrument deployment and robotic arm, nano-rover, sampling, drilling; Sample finder and collector. There are technologies in robotic and human exploration that are a drive for the creativity and economical competitivity of our industries: Mecha-electronics-sensors; Tele control, telepresence, virtual reality; Regional mobility rover; Autonomy and Navigation; Artificially intelligent robots, Complex systems, Man-Machine interface and performances. Moon-Mars Exploration can inspire solutions to global Earth sustained development: In-Situ Utilisation of resources; Establishment of permanent robotic infrastructures, Environmental protection aspects; Life sciences laboratories; Support to human exploration. We also report on the IAA Cosmic Study on Next Steps In Exploring Deep Space, and ongoing IAA Cosmic Studies, ILEWG/IMEWG ongoing activities, and we finally discuss possible roadmaps for robotic and human exploration, starting with the Moon-Mars missions for the coming decade, and building effectively on joint technology developments.

Extra-terrestrial life in the European Space Agency's Cosmic Vision plan and beyond.

PubMed

Fridlund, Malcolm

2011-02-13

Our exciting time allows us to contemplate the moment in the not-too-distant future when we can detect the presence of life on worlds orbiting stars other than our Sun. It will not be easy and will require the development and use of the very latest technologies. It also very probably demands deployment in space of relevant instrumentation in order to carry out these investigations. The European Space Agency has been involved in the studies and development of the required technologies for more than a decade and is currently formulating a roadmap for how to achieve the ultimate detection of signs of life as we know it on terrestrial exoplanets. The major elements of the roadmap consist of the following. First, the search for and detection of terrestrial exoplanets. Here, some progress has been made recently and is reported in this paper. Second, the more and more detailed study of the physical characteristics of such exoplanets. Finally, the search for biomarkers--indicators of biological activity--that can be observed at interstellar distances. The last is probably one of the most difficult problems ever contemplated by observational astronomy.

Ecosystem services provided by a complex coastal region: challenges of classification and mapping.

PubMed

Sousa, Lisa P; Sousa, Ana I; Alves, Fátima L; Lillebø, Ana I

2016-03-11

A variety of ecosystem services classification systems and mapping approaches are available in the scientific and technical literature, which needs to be selected and adapted when applied to complex territories (e.g. in the interface between water and land, estuary and sea). This paper provides a framework for addressing ecosystem services in complex coastal regions. The roadmap comprises the definition of the exact geographic boundaries of the study area; the use of CICES (Common International Classification of Ecosystem Services) for ecosystem services identification and classification; and the definition of qualitative indicators that will serve as basis to map the ecosystem services. Due to its complexity, the Ria de Aveiro coastal region was selected as case study, presenting an opportunity to explore the application of such approaches at a regional scale. The main challenges of implementing the proposed roadmap, together with its advantages are discussed in this research. The results highlight the importance of considering both the connectivity of natural systems and the complexity of the governance framework; the flexibility and robustness, but also the challenges when applying CICES at regional scale; and the challenges regarding ecosystem services mapping.

Wireless Technology Use Case Requirement Analysis for Future Space Applications

NASA Technical Reports Server (NTRS)

Abedi, Ali; Wilkerson, DeLisa

2016-01-01

This report presents various use case scenarios for wireless technology -including radio frequency (RF), optical, and acoustic- and studies requirements and boundary conditions in each scenario. The results of this study can be used to prioritize technology evaluation and development and in the long run help in development of a roadmap for future use of wireless technology. The presented scenarios cover the following application areas: (i) Space Vehicles (manned/unmanned), (ii) Satellites and Payloads, (iii) Surface Explorations, (iv) Ground Systems, and (v) Habitats. The requirement analysis covers two parallel set of conditions. The first set includes the environmental conditions such as temperature, radiation, noise/interference, wireless channel characteristics and accessibility. The second set of requirements are dictated by the application and may include parameters such as latency, throughput (effective data rate), error tolerance, and reliability. This report provides a comprehensive overview of all requirements from both perspectives and details their effects on wireless system reliability and network design. Application area examples are based on 2015 NASA Technology roadmap with specific focus on technology areas: TA 2.4, 3.3, 5.2, 5.5, 6.4, 7.4, and 10.4 sections that might benefit from wireless technology.

Ecosystem services provided by a complex coastal region: challenges of classification and mapping

PubMed Central

Sousa, Lisa P.; Sousa, Ana I.; Alves, Fátima L.; Lillebø, Ana I.

2016-01-01

A variety of ecosystem services classification systems and mapping approaches are available in the scientific and technical literature, which needs to be selected and adapted when applied to complex territories (e.g. in the interface between water and land, estuary and sea). This paper provides a framework for addressing ecosystem services in complex coastal regions. The roadmap comprises the definition of the exact geographic boundaries of the study area; the use of CICES (Common International Classification of Ecosystem Services) for ecosystem services identification and classification; and the definition of qualitative indicators that will serve as basis to map the ecosystem services. Due to its complexity, the Ria de Aveiro coastal region was selected as case study, presenting an opportunity to explore the application of such approaches at a regional scale. The main challenges of implementing the proposed roadmap, together with its advantages are discussed in this research. The results highlight the importance of considering both the connectivity of natural systems and the complexity of the governance framework; the flexibility and robustness, but also the challenges when applying CICES at regional scale; and the challenges regarding ecosystem services mapping. PMID:26964892

It’s Time for An Epigenomics Roadmap of Heart Failure

PubMed Central

Papait, Roberto; Corrado, Nadia; Rusconi, Francesca; Serio, Simone; V.G. Latronico, Michael

2015-01-01

The post-genomic era has completed its first decade. During this time, we have seen an attempt to understand life not just through the study of individual isolated processes, but through the appreciation of the amalgam of complex networks, within which each process can influence others. Greatly benefiting this view has been the study of the epigenome, the set of DNA and histone protein modifications that regulate gene expression and the function of regulatory non-coding RNAs without altering the DNA sequence itself. Indeed, the availability of reference genome assemblies of many species has led to the development of methodologies such as ChIP-Seq and RNA-Seq that have allowed us to define with high resolution the genomic distribution of several epigenetic elements and to better comprehend how they are interconnected for the regulation of gene expression. In the last few years, the use of these methodologies in the cardiovascular field has contributed to our understanding of the importance of epigenetics in heart diseases, giving new input to this area of research. Here, we review recently acquired knowledge on the role of the epigenome in heart failure, and discuss the need of an epigenomics roadmap for cardiovascular disease. PMID:27006627

A roadmap for the study of conscious audition and its neural basis

PubMed Central

Cariani, Peter A.; Gutschalk, Alexander

2017-01-01

How and which aspects of neural activity give rise to subjective perceptual experience—i.e. conscious perception—is a fundamental question of neuroscience. To date, the vast majority of work concerning this question has come from vision, raising the issue of generalizability of prominent resulting theories. However, recent work has begun to shed light on the neural processes subserving conscious perception in other modalities, particularly audition. Here, we outline a roadmap for the future study of conscious auditory perception and its neural basis, paying particular attention to how conscious perception emerges (and of which elements or groups of elements) in complex auditory scenes. We begin by discussing the functional role of the auditory system, particularly as it pertains to conscious perception. Next, we ask: what are the phenomena that need to be explained by a theory of conscious auditory perception? After surveying the available literature for candidate neural correlates, we end by considering the implications that such results have for a general theory of conscious perception as well as prominent outstanding questions and what approaches/techniques can best be used to address them. This article is part of the themed issue ‘Auditory and visual scene analysis’. PMID:28044014

Hot kinetic model as a guide to improve organic photovoltaic materials.

PubMed

Sosorev, Andrey Yu; Godovsky, Dmitry Yu; Paraschuk, Dmitry Yu

2018-01-31

The modeling of organic solar cells (OSCs) can provide a roadmap for their further improvement. Many OSC models have been proposed in recent years; however, the impact of the key intermediates from photons to electricity-hot charge-transfer (CT) states-on the OSC efficiency is highly ambiguous. In this study, we suggest an analytical kinetic model for OSC that considers a two-step charge generation via hot CT states. This hot kinetic model allowed us to evaluate the impact of different material parameters on the OSC performance: the driving force for charge separation, optical bandgap, charge mobility, geminate recombination rate, thermalization rate, average electron-hole separation distance in the CT state, dielectric permittivity, reorganization energy and charge delocalization. In contrast to a widespread trend of lowering the material bandgap, the model predicts that this approach is only efficient along with improvement of the other material properties. The most promising ways to increase the OSC performance are decreasing the reorganization energy, i.e., an energy change accompanying CT from the donor molecule to the acceptor, increasing the dielectric permittivity and charge delocalization. The model suggests that there are no fundamental limitations that can prevent achieving the OSC efficiency above 20%.

Finding a roadmap to achieve large neuromorphic hardware systems

PubMed Central

Hasler, Jennifer; Marr, Bo

2013-01-01

Neuromorphic systems are gaining increasing importance in an era where CMOS digital computing techniques are reaching physical limits. These silicon systems mimic extremely energy efficient neural computing structures, potentially both for solving engineering applications as well as understanding neural computation. Toward this end, the authors provide a glimpse at what the technology evolution roadmap looks like for these systems so that Neuromorphic engineers may gain the same benefit of anticipation and foresight that IC designers gained from Moore's law many years ago. Scaling of energy efficiency, performance, and size will be discussed as well as how the implementation and application space of Neuromorphic systems are expected to evolve over time. PMID:24058330

The Open Gateway: Lunar Exploration in 2050

NASA Technical Reports Server (NTRS)

Lawrence, S.; Neal, C.

2017-01-01

The Moon, with its fundamental science questions and abundant, potentially useful re-sources, is the most viable destination for near-term future human and robotic exploration. Given what we have learned since Apollo, the lunar frontier now presents an entirely new paradigm for planetary exploration. The Lunar Exploration Roadmap [1], which was jointly developed by engineers, planetary scientists, commercial entities, and policymakers, is the cohesive strategic plan for using the Moon and its resources to enable the exploration of all other destinations within the Solar system by leveraging incremental, affordable investments in cislunar infrastructure. Here, we summarize the Lunar Exploration Roadmap, and describe the immense benefits that will arise from its successful implementation.

A Roadmap of Innovative Nuclear Energy System

NASA Astrophysics Data System (ADS)

Sekimoto, Hiroshi

2017-01-01

Nuclear is a dense energy without CO2 emission. It can be used for more than 100,000 years using fast breeder reactors with uranium from the sea. However, it raises difficult problems associated with severe accidents, spent fuel waste and nuclear threats, which should be solved with acceptable costs. Some innovative reactors have attracted interest, and many designs have been proposed for small reactors. These reactors are considered much safer than conventional large reactors and have fewer technical obstructions. Breed-and-burn reactors have high potential to solve all inherent problems for peaceful use of nuclear energy. However, they have some technical problems with materials. A roadmap for innovative reactors is presented herein.

Comparison of Historic Exploration with Contemporary Space Policy Suggests a Retheorisation of Settings

NASA Astrophysics Data System (ADS)

Cokely, J.; Rankin, W.; Heinrich, P.; McAuliffe, M.

The 2008 NASA Astrobiology Roadmap provides one way of theorising this developing field, a way which has become the normative model for the discipline: science-and scholarship-driven funding for space. By contrast, a novel re-evaluation of funding policies is undertaken in this article to reframe astrobiology, terraforming and associated space travel and research. Textual visualisation, discourse and numeric analytical methods, and value theory are applied to historical data and contemporary sources to re-investigate significant drivers and constraints on the mechanisms of enabling space exploration. Two data sets are identified and compared: the business objectives and outcomes of major 15th-17th century European joint-stock exploration and trading companies and a case study of a current space industry entrepreneur company. Comparison of these analyses suggests that viable funding policy drivers can exist outside the normative science and scholarship-driven roadmap. The two drivers identified in this study are (1) the intrinsic value of space as a territory to be experienced and enjoyed, not just studied, and (2) the instrumental, commercial value of exploiting these experiences by developing infrastructure and retail revenues. Filtering of these results also offers an investment rationale for companies operating in, or about to enter, the space business marketplace.

2.0 AEDL Systems Engineering

NASA Technical Reports Server (NTRS)

Graves, Claude

2005-01-01

Some engineering topics: Some Initial Thoughts. Capability Description. Capability State-of-the-Art. Capability Requirements. Systems Engineering. Capability Roadmap. Capability Maturity. Candidate Technologies. Metrics.

Roadmap on quantum optical systems

NASA Astrophysics Data System (ADS)

Dumke, Rainer; Lu, Zehuang; Close, John; Robins, Nick; Weis, Antoine; Mukherjee, Manas; Birkl, Gerhard; Hufnagel, Christoph; Amico, Luigi; Boshier, Malcolm G.; Dieckmann, Kai; Li, Wenhui; Killian, Thomas C.

2016-09-01

This roadmap bundles fast developing topics in experimental optical quantum sciences, addressing current challenges as well as potential advances in future research. We have focused on three main areas: quantum assisted high precision measurements, quantum information/simulation, and quantum gases. Quantum assisted high precision measurements are discussed in the first three sections, which review optical clocks, atom interferometry, and optical magnetometry. These fields are already successfully utilized in various applied areas. We will discuss approaches to extend this impact even further. In the quantum information/simulation section, we start with the traditionally successful employed systems based on neutral atoms and ions. In addition the marvelous demonstrations of systems suitable for quantum information is not progressing, unsolved challenges remain and will be discussed. We will also review, as an alternative approach, the utilization of hybrid quantum systems based on superconducting quantum devices and ultracold atoms. Novel developments in atomtronics promise unique access in exploring solid-state systems with ultracold gases and are investigated in depth. The sections discussing the continuously fast-developing quantum gases include a review on dipolar heteronuclear diatomic gases, Rydberg gases, and ultracold plasma. Overall, we have accomplished a roadmap of selected areas undergoing rapid progress in quantum optics, highlighting current advances and future challenges. These exciting developments and vast advances will shape the field of quantum optics in the future.

HTA Implementation Roadmap in Central and Eastern European Countries.

PubMed

Kaló, Zoltán; Gheorghe, Adrian; Huic, Mirjana; Csanádi, Marcell; Kristensen, Finn Boerlum

2016-02-01

The opportunity cost of inappropriate health policy decisions is greater in Central and Eastern European (CEE) compared with Western European (WE) countries because of poorer population health and more limited healthcare resources. Application of health technology assessment (HTA) prior to healthcare financing decisions can improve the allocative efficiency of scarce resources. However, few CEE countries have a clear roadmap for HTA implementation. Examples from high-income countries may not be directly relevant, as CEE countries cannot allocate so much financial and human resources for substantiating policy decisions with evidence. Our objective was to describe the main HTA implementation scenarios in CEE countries and summarize the most important questions related to capacity building, financing HTA research, process and organizational structure for HTA, standardization of HTA methodology, use of local data, scope of mandatory HTA, decision criteria, and international collaboration in HTA. Although HTA implementation strategies from the region can be relevant examples for other CEE countries with similar cultural environment and economic status, HTA roadmaps are not still fully transferable without taking into account country-specific aspects, such as country size, gross domestic product per capita, major social values, public health priorities, and fragmentation of healthcare financing. © 2016 The Authors. Health Economics published by John Wiley & Sons Ltd.

The Harmonizing Outcome Measures for Eczema (HOME) roadmap: a methodological framework to develop core sets of outcome measurements in dermatology.

PubMed

Schmitt, Jochen; Apfelbacher, Christian; Spuls, Phyllis I; Thomas, Kim S; Simpson, Eric L; Furue, Masutaka; Chalmers, Joanne; Williams, Hywel C

2015-01-01

Core outcome sets (COSs) are consensus-derived minimum sets of outcomes to be assessed in a specific situation. COSs are being increasingly developed to limit outcome-reporting bias, allow comparisons across trials, and strengthen clinical decision making. Despite the increasing interest in outcomes research, methods to develop COSs have not yet been standardized. The aim of this paper is to present the Harmonizing Outcomes Measures for Eczema (HOME) roadmap for the development and implementation of COSs, which was developed on the basis of our experience in the standardization of outcome measurements for atopic eczema. Following the establishment of a panel representing all relevant stakeholders and a research team experienced in outcomes research, the scope and setting of the core set should be defined. The next steps are the definition of a core set of outcome domains such as symptoms or quality of life, followed by the identification or development and validation of appropriate outcome measurement instruments to measure these core domains. Finally, the consented COS needs to be disseminated, implemented, and reviewed. We believe that the HOME roadmap is a useful methodological framework to develop COSs in dermatology, with the ultimate goal of better decision making and promoting patient-centered health care.

Integrating MPI and deduplication engines: a software architecture roadmap.

PubMed

Baksi, Dibyendu

2009-03-01

The objective of this paper is to clarify the major concepts related to architecture and design of patient identity management software systems so that an implementor looking to solve a specific integration problem in the context of a Master Patient Index (MPI) and a deduplication engine can address the relevant issues. The ideas presented are illustrated in the context of a reference use case from Integrating the Health Enterprise Patient Identifier Cross-referencing (IHE PIX) profile. Sound software engineering principles using the latest design paradigm of model driven architecture (MDA) are applied to define different views of the architecture. The main contribution of the paper is a clear software architecture roadmap for implementors of patient identity management systems. Conceptual design in terms of static and dynamic views of the interfaces is provided as an example of platform independent model. This makes the roadmap applicable to any specific solutions of MPI, deduplication library or software platform. Stakeholders in need of integration of MPIs and deduplication engines can evaluate vendor specific solutions and software platform technologies in terms of fundamental concepts and can make informed decisions that preserve investment. This also allows freedom from vendor lock-in and the ability to kick-start integration efforts based on a solid architecture.

NASA Net Zero Energy Buildings Roadmap

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pless, S.; Scheib, J.; Torcellini, P.

In preparation for the time-phased net zero energy requirement for new federal buildings starting in 2020, set forth in Executive Order 13514, NASA requested that the National Renewable Energy Laboratory (NREL) to develop a roadmap for NASA's compliance. NASA detailed a Statement of Work that requested information on strategic, organizational, and tactical aspects of net zero energy buildings. In response, this document presents a high-level approach to net zero energy planning, design, construction, and operations, based on NREL's first-hand experience procuring net zero energy construction, and based on NREL and other industry research on net zero energy feasibility. The strategicmore » approach to net zero energy starts with an interpretation of the executive order language relating to net zero energy. Specifically, this roadmap defines a net zero energy acquisition process as one that sets an aggressive energy use intensity goal for the building in project planning, meets the reduced demand goal through energy efficiency strategies and technologies, then adds renewable energy in a prioritized manner, using building-associated, emission- free sources first, to offset the annual energy use required at the building; the net zero energy process extends through the life of the building, requiring a balance of energy use and production in each calendar year.« less

Cell Science and Cell Biology Research at MSFC: Summary

NASA Technical Reports Server (NTRS)

2003-01-01

The common theme of these research programs is that they investigate regulation of gene expression in cells, and ultimately gene expression is controlled by the macromolecular interactions between regulatory proteins and DNA. The NASA Critical Path Roadmap identifies Muscle Alterations and Atrophy and Radiation Effects as Very Serious Risks and Severe Risks, respectively, in long term space flights. The specific problem addressed by Dr. Young's research ("Skeletal Muscle Atrophy and Muscle Cell Signaling") is that skeletal muscle loss in space cannot be prevented by vigorous exercise. Aerobic skeletal muscles (i.e., red muscles) undergo the most extensive atrophy during long-term space flight. Of the many different potential avenues for preventing muscle atrophy, Dr. Young has chosen to study the beta-adrenergic receptor (betaAR) pathway. The reason for this choice is that a family of compounds called betaAR agonists will preferentially cause an increase in muscle mass of aerobic muscles (i.e., red muscle) in animals, potentially providing a specific pharmacological solution to muscle loss in microgravity. In addition, muscle atrophy is a widespread medical problem in neuromuscular diseases, spinal cord injury, lack of exercise, aging, and any disease requiring prolonged bedridden status. Skeletal muscle cells in cell culture are utilized as a model system to study this problem. Dr. Richmond's research ("Radiation & Cancer Biology of Mammary Cells in Culture") is directed toward developing a laboratory model for use in risk assessment of cancer caused by space radiation. This research is unique because a human model will be developed utilizing human mammary cells that are highly susceptible to tumor development. This approach is preferential over using animal cells because of problems in comparing radiation-induced cancers between humans and animals.

Enterprise application architecture development based on DoDAF and TOGAF

NASA Astrophysics Data System (ADS)

Tao, Zhi-Gang; Luo, Yun-Feng; Chen, Chang-Xin; Wang, Ming-Zhe; Ni, Feng

2017-05-01

For the purpose of supporting the design and analysis of enterprise application architecture, here, we report a tailored enterprise application architecture description framework and its corresponding design method. The presented framework can effectively support service-oriented architecting and cloud computing by creating the metadata model based on architecture content framework (ACF), DoDAF metamodel (DM2) and Cloud Computing Modelling Notation (CCMN). The framework also makes an effort to extend and improve the mapping between The Open Group Architecture Framework (TOGAF) application architectural inputs/outputs, deliverables and Department of Defence Architecture Framework (DoDAF)-described models. The roadmap of 52 DoDAF-described models is constructed by creating the metamodels of these described models and analysing the constraint relationship among metamodels. By combining the tailored framework and the roadmap, this article proposes a service-oriented enterprise application architecture development process. Finally, a case study is presented to illustrate the results of implementing the tailored framework in the Southern Base Management Support and Information Platform construction project using the development process proposed by the paper.

RTS,S: Toward a first landmark on the Malaria Vaccine Technology Roadmap.

PubMed

Kaslow, David C; Biernaux, Sophie

2015-12-22

The Malaria Vaccine Technology Roadmap calls for a 2015 landmark goal of a first-generation malaria vaccine that has protective efficacy against severe disease and death, lasting longer than one year. This review focuses on product development efforts over the last five years of RTS,S, a pre-erythrocytic, recombinant subunit, adjuvanted, candidate malaria vaccine designed with this goal of a first-generation malaria vaccine in mind. RTS,S recently completed a successful pivotal Phase III safety, efficacy and immunogenicity study. Although vaccine efficacy was found to be modest, a substantial number of cases of clinical malaria were averted over a 3-4 years period, particularly in settings of significant disease burden. European regulators have subsequently adopted a positive opinion under the Article 58 procedure for an indication of active immunization of children aged 6 weeks up to 17 months against malaria caused by Plasmodium falciparum and against hepatitis B. Further evaluations of the benefit, risk, feasibility and cost-effectiveness of RTS,S are now anticipated through policy and financing reviews at the global and national levels. Copyright © 2015. Published by Elsevier Ltd.

Strengthening the Role of Nurses in Medical Device Development.

PubMed

Castner, Jessica; Sullivan, Suzanne S; Titus, Albert H; Klingman, Karen J

2016-01-01

Medical devices and innovative technology promise to revolutionize health care. Despite the importance of involving nurses in the collaborative medical device development processes, there are few learning opportunities in nursing programs. The purpose of this article is to provide a conceptual guide for nurse educators and researchers to engage nursing expertise in medical device development processes. A review of the literature guided the creation of the "Strengthening the Role of Nurses in Medical Device Development Roadmap" model. The model was used to describe how nurses can be engaged in multidisciplinary design of medical devices. An academic transdisciplinary team piloted the application of the model. The model includes the stages of needs assessment, planned brainstorm, feasibility determination, concept design, and prototype building. A transdisciplinary team case study of improving an asthma home-monitoring devices illustrates effective application of the model. Nurse leaders in the academic setting can effectively use the "Strengthening the Role of Nurses in Medical Device Development Roadmap" to inform their engagement of nurses in early medical device development and innovation processes. Copyright © 2016 Elsevier Inc. All rights reserved.

Developing the "Lunar Vicinity" Scenario of the Global Exploration Roadmap

NASA Astrophysics Data System (ADS)

Schmidt, G.; Neal, C. R.; Crawford, I. A.; Ehrenfreund, P.

2014-04-01

The Global Exploration Roadmap (GER, [1]) has been developed by the International Space Exploration Coordination Group (ISECG - comprised of 14 space agencies) to define various pathways to getting humans beyond low Earth orbit and eventually to Mars. Such pathways include visiting asteroids or the Moon before going on to Mars. This document has been written at a very high level and many details are still to be determined. However, a number of important papers regarding international space exploration can form a basis for this document (e.g. [2,3]). In this presentation, we focus on developing the "Lunar Vicinity" scenario by adding detail via mapping a number of recent reports/documents into the GER. Precedence for this scenario is given by Szajnfarber et al. [4] who stated "We find that when international partners are considered endogenously, the argument for a "flexible path" approach is weakened substantially. This is because international contributions can make "Moon first" economically feasible". The documents highlighted here are in no way meant to be all encompassing and other documents can and should be added, (e.g., the JAXA Space Exploration Roadmap). This exercise is intended to demonstrate that existing documents can be mapped into the GER despite the major differences in granularity, and that this mapping is a way to promote broader national and international buy-in to the Lunar Vicinity scenario. The documents used here are: the Committee on Space Research (COSPAR) Panel on Exploration report on developing a global space exploration program [5], the Strategic Knowledge Gaps (SKGs) report from the Lunar Exploration Analysis Group (LEAG) [6], the Lunar Exploration Roadmap developed by LEAG [7], the National Research Council report Scientific Context for the Exploration of the Moon (SCEM) [8], the scientific rationale for resuming lunar surface exploration [9], the astrobiological benefits of human space exploration [9,10].

Innovation Partnership for a Roadmap on Vaccines in Europe (IPROVE): A vision for the vaccines of tomorrow.

PubMed

Medaglini, Donata; De Azero, Magdalena R; Leroy, Odile; Bietrix, Florence; Denoel, Philippe

2018-02-21

A clear vision for vaccines research and development (R&D) is needed if Europe is to continue to lead the discovery of next generation vaccines. Innovation Partnership for a Roadmap on Vaccines in Europe (IPROVE) is a collaboration between leading vaccine experts to develop a roadmap setting out how Europe can best invest in the science and technology essential for vaccines innovation. This FP7 project, started in December 2013, brought together more than 130 key public and private stakeholders from academia, public health institutes, regulators, industry and small and medium-sized enterprises to determine and prioritise the gaps and challenges to be addressed to bolster innovation in vaccines and vaccination in Europe. The IPROVE consultation process was structured around seven themes: vaccine R&D, manufacturing and quality control, infrastructure, therapeutic vaccines, needs of small and medium-sized enterprises, vaccines acceptance and training needs. More than 80 recommendations were made by the consultation groups, mainly focused on the need for a multidisciplinary research approach to stimulate innovation, accelerated translation of scientific knowledge into technological innovation, and fostering of real collaboration within the European vaccine ecosystem. The consultation also reinforced the fact that vaccines are only as good as their vaccine implementation programmes, and that more must be done to understand and address vaccination hesitancy of both the general public and healthcare professionals. Bringing together a wide range of stakeholders to work on the IPROVE roadmap has increased mutual understanding of their different perspectives, needs and priorities. IPROVE is a first attempt to develop such a comprehensive view of the vaccine sector. This prioritisation effort, aims to help policy-makers and funders identify those vaccine-related areas and technologies where key investment is needed for short and medium-long term success. Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.

A roadmap towards advanced space weather science to protect society's technological infrastructure: Panel Discussion 3

NASA Astrophysics Data System (ADS)

Schrijver, Carolus; Kauristie, Kirsti

This single 90minute slot will follow on from the morning plenary presentation of the roadmap, providing an opportunity for further discussion of the panel’s findings with an invited panel of key stakeholders. --- As mankind’s technological capabilities grow, society constructs a rapidly deepening insight into the workings of the universe at large, being guided by exploring space near to our home. But at the same time our societal dependence on technology increases and with that comes a growing appreciation of the challenges presented by the phenomena that occur in that space around our home planet: Magnetic explosions on the Sun and their counterparts in the geomagnetic field can in extreme cases endanger our all-pervasive electrical infrastructure. Powerful space storms occasionally lower the reliability of the globe-spanning satellite navigation systems and interrupt radio communications. Energetic particle storms lead to malfunctions and even failures in satellites that are critical to the flow of information in the globally connected economies. These and other Sun-driven effects on Earth’s environment, collectively known as space weather, resemble some other natural hazards in the sense that they pose a risk for the safe and efficient functioning of society that needs to be understood, quantified, and - ultimately - mitigated against. The complexity of the coupled Sun-Earth system, the sparseness by which it can be covered by remote-sensing and in-situ instrumentation, and the costs of the required observational and computational infrastructure warrant a well-planned and well-coordinated approach with cost-efficient solutions. Our team is tasked with the development of a roadmap with the goal of demonstrably improving our observational capabilities, scientific understanding, and the ability to forecast. This paper summarizes the accomplishments of the roadmap team in identifying the highest-priority challenges to achieve these goals.

A roadmap towards advanced space weather science to protect society's technological infrastructure: Panel Discussion 1

NASA Astrophysics Data System (ADS)

Schrijver, Carolus; Kauristie, Kirsti

This single 90minute slot will follow on from the morning plenary presentation of the roadmap, providing an opportunity for further discussion of the panel’s findings with an invited panel of key stakeholders. --- As mankind’s technological capabilities grow, society constructs a rapidly deepening insight into the workings of the universe at large, being guided by exploring space near to our home. But at the same time our societal dependence on technology increases and with that comes a growing appreciation of the challenges presented by the phenomena that occur in that space around our home planet: Magnetic explosions on the Sun and their counterparts in the geomagnetic field can in extreme cases endanger our all-pervasive electrical infrastructure. Powerful space storms occasionally lower the reliability of the globe-spanning satellite navigation systems and interrupt radio communications. Energetic particle storms lead to malfunctions and even failures in satellites that are critical to the flow of information in the globally connected economies. These and other Sun-driven effects on Earth’s environment, collectively known as space weather, resemble some other natural hazards in the sense that they pose a risk for the safe and efficient functioning of society that needs to be understood, quantified, and - ultimately - mitigated against. The complexity of the coupled Sun-Earth system, the sparseness by which it can be covered by remote-sensing and in-situ instrumentation, and the costs of the required observational and computational infrastructure warrant a well-planned and well-coordinated approach with cost-efficient solutions. Our team is tasked with the development of a roadmap with the goal of demonstrably improving our observational capabilities, scientific understanding, and the ability to forecast. This paper summarizes the accomplishments of the roadmap team in identifying the highest-priority challenges to achieve these goals.

A roadmap towards advanced space weather science to protect society's technological infrastructure: Panel Discussion 2

NASA Astrophysics Data System (ADS)

Schrijver, Carolus; Kauristie, Kirsti

This single 90minute slot will follow on from the morning plenary presentation of the roadmap, providing an opportunity for further discussion of the panel’s findings with an invited panel of key stakeholders. --- As mankind’s technological capabilities grow, society constructs a rapidly deepening insight into the workings of the universe at large, being guided by exploring space near to our home. But at the same time our societal dependence on technology increases and with that comes a growing appreciation of the challenges presented by the phenomena that occur in that space around our home planet: Magnetic explosions on the Sun and their counterparts in the geomagnetic field can in extreme cases endanger our all-pervasive electrical infrastructure. Powerful space storms occasionally lower the reliability of the globe-spanning satellite navigation systems and interrupt radio communications. Energetic particle storms lead to malfunctions and even failures in satellites that are critical to the flow of information in the globally connected economies. These and other Sun-driven effects on Earth’s environment, collectively known as space weather, resemble some other natural hazards in the sense that they pose a risk for the safe and efficient functioning of society that needs to be understood, quantified, and - ultimately - mitigated against. The complexity of the coupled Sun-Earth system, the sparseness by which it can be covered by remote-sensing and in-situ instrumentation, and the costs of the required observational and computational infrastructure warrant a well-planned and well-coordinated approach with cost-efficient solutions. Our team is tasked with the development of a roadmap with the goal of demonstrably improving our observational capabilities, scientific understanding, and the ability to forecast. This paper summarizes the accomplishments of the roadmap team in identifying the highest-priority challenges to achieve these goals.

Young Carers' Educational Experiences and Support: A Roadmap for the Development of School Policies to Foster Their Academic Success

ERIC Educational Resources Information Center

Lakman, Yana; Chalmers, Heather; Sexton, Cayleigh

2017-01-01

Young Carers (YCs) provide care for ill, disabled, or addicted family member(s) and may experience risk to their educational success. This study examined 145 YCs in Southern Ontario, aged 8-18, using surveys and found that many YCs considered school important and were doing well academically whereas some YCs' education was negatively impacted.…

Carbon stocks on forestland of the United States, with emphasis on USDA Forest Service ownership

Treesearch

Linda S. Heath; James E. Smith; Christopher W. Woodall; David L. Azuma; Karen L. Waddell

2011-01-01

The U.S. Department of Agriculture Forest Service (USFS) manages one-fifth of the area of forestland in the United States. The Forest Service Roadmap for responding to climate change identified assessing and managing carbon stocks and change as a major element of its plan. This study presents methods and results of estimating current forest carbon stocks and change in...

Carbon stocks on forestland of the United States, with emphaisis on USDA Forest Service ownership

Treesearch

Linda S. Heath; James E. Smith; Christopher W. Woodall; Dave Azuma; Karen L. Waddell

2011-01-01

The U.S. Department of Agriculture Forest Service (USFS) manages one-fifth of the area of forestland in the United States. The Forest Service Roadmap for responding to climate change identified assessing and managing carbon stocks and change as a major element of its plan. This study presents methods and results of estimating current forest carbon stocks and change in...

Air Force and Diversity: The Awkward Embrace

DTIC Science & Technology

2013-02-14

Streeter is a U.S. Air Force intelligence officer assigned to the Air War College, Air University, Maxwell AFB, AL. She graduated from the United States...future leaders.” Princeton University Office of Human Resources Web site; Wilson et al, Grooming Top Leaders, 4. 28 45. Dr Fil J . Arenas...Air Force Diversity Strategic Roadmap (2012), 14. 86. Dr. Fil J . Arenas (Associate Professor, Organizational Leadership Studies, Squadron

The NASA Planetary Data System Roadmap Study for 2017 - 2026

NASA Astrophysics Data System (ADS)

McNutt, R. L., Jr.; Gaddis, L. R.; Law, E.; Beyer, R. A.; Crombie, M. K.; Ebel, D. S. S.; Ghosh, A.; Grayzeck, E.; Morgan, T. H.; Paganelli, F.; Raugh, A.; Stein, T.; Tiscareno, M. S.; Weber, R. C.; Banks, M.; Powell, K.

2017-12-01

NASA's Planetary Data System (PDS) is the formal archive of >1.2 petabytes of data from planetary exploration, science, and research. Initiated in 1989 to address an overall lack of attention to mission data documentation, access, and archiving, the PDS has evolved into an online collection of digital data managed and served by a federation of six science discipline nodes and two technical support nodes. Several ad hoc mission-oriented data nodes also provide complex data interfaces and access for the duration of their missions. The recent Planetary Data System Roadmap Study for 2017 to 2026 involved 15 planetary science community members who collectively prepared a report summarizing the results of an intensive examination of the current state of the PDS and its organization, management, practices, and data holdings (https://pds.jpl.nasa.gov/roadmap/PlanetaryDataSystemRMS17-26_20jun17.pdf). The report summarizes the history of the PDS, its functions and characteristics, and how it has evolved to its present form; also included are extensive references and documentary appendices. The report recognizes that as a complex, evolving, archive system, the PDS must constantly respond to new pressures and opportunities. The report provides details on the challenges now facing the PDS, 19 detailed findings, suggested remediations, and a summary of what the future may hold for planetary data archiving. The findings cover topics such as user needs and expectations, data usability and discoverability (i.e., metadata, data access, documentation, and training), tools and file formats, use of current information technologies, and responses to increases in data volume, variety, complexity, and number of data providers. In addition, the study addresses the possibility of archiving software, laboratory data, and measurements of physical samples. Finally, the report discusses the current structure and governance of the PDS and its impact on how archive growth, technology, and new developments are enabled and managed within the PDS. The report, with its findings, acknowledges the ongoing and expected challenges to be faced in the future, the need for maintaining an edge in the use of emerging technologies, and represents a guide for evolution of the PDS for the next decade.

An Overview of the Planetary Data System Roadmap Study for 2017 - 2026

NASA Astrophysics Data System (ADS)

Morgan, Thomas H.; McNutt, Ralph L.; Gaddis, Lisa; Law, Emily; Beyer, Ross A.; Crombie, Kate; Ebel, Denton; Ghosh, Amitahba; Grayzeck, Edwin J.; Paganelli, Flora; Raugh, Anne C.; Stein, Thomas; Tiscareno, Matthew S.; Weber, Renee; E Banks, Maria; Powell, Kathryn

2017-10-01

NASA’s Planetary Data System (PDS) is the formal archive of >1.2 petabytes of data from planetary exploration, science, and research. Initiated in 1989 to address an overall lack of attention to mission data documentation, access, and archiving, the PDS has since evolved into an online collection of digital data managed and served by a federation of 6 science discipline nodes and 2 technical support nodes. Several ad-hoc mission-oriented data nodes also provide complex data interfaces and access for the duration of their missions.The new PDS Roadmap Study for 2017-2026 involved 15 planetary science community members who collectively prepared a report summarizing the results of an intensive examination of the current state of the PDS and its organization, management, practices, and data holdings (https://pds.jpl.nasa.gov/roadmap/PlanetaryDataSystemRMS17-26_20jun17.pdf). The report summarizes PDS history, its functions and characteristics, and its present form; also included are extensive references and documentary appendices. The report recognizes that as a complex evolving system, the PDS must respond to new pressures and opportunities. The report provides details on challenges now facing the PDS, 19 detailed findings and suggested remediations that could be used to respond to these findings, and a summary of the potential future of planetary data archiving. These findings cover topics such as user needs and expectations, data usability and discoverability (i.e., metadata, data access, documentation, and training), tools and file formats, use of current information technologies, and responses to increases in data volume, variety, complexity, and number of data providers. In addition, the study addresses the possibility of archiving software, laboratory data, and physical samples. Finally, the report discusses the current structure and governance of PDS and the impact of this on how archive growth, technology, and new developments are enabled and managed within the PDS. The report, with its findings, acknowledges the ongoing and expected challenges to be faced in the future, the need for maintaining an edge on the use of emerging technologies, and represents a guide for evolution of the PDS for the next decade.

A Technology Development Roadmap for a Near-Term Probe-Class X-ray Astrophysics Mission

NASA Technical Reports Server (NTRS)

Daelemans, Gerard J.; Petre, Robert; Bookbinder, Jay; Ptak, Andrew; Smith, Randall

2013-01-01

This document presents a roadmap, including proposed budget and schedule, for maturing the instrumentation needed for an X-ray astrophysics Probe-class mission. The Physics of the Cosmos (PCOS) Program Office was directed to create this roadmap following the December 2012 NASA Astrophysics Implementation Plan (AIP). Definition of this mission is called for in the AIP, with the possibility of selection in 2015 for a start in 2017. The overall mission capabilities and instrument performance requirements were defined in the 2010 Astronomy and Astrophysics Decadal Survey report, New Worlds, New Horizons in Astronomy and Astrophysics (NWNH), in connection with the highly ranked International X-ray Observatory (IXO). In NWNH, recommendations were provided regarding the size of, and instrumentation needed by, the next large X-ray observatory. Specifically, the key instrumental capability would be an X-ray calorimeter spectrometer at the focus of a large mirror with angular resolution of 10 arc seconds (arcsec) or better. If possible, a grating spectrometer should also be incorporated into the instrument complement. In response to these recommendations, four instrumentation technologies are included in this roadmap. Three of these are critical for an X-ray mission designed to address NWNH questions: segmented X-ray mirrors, transition edge sensor calorimeters, and gratings. Two approaches are described for gratings, which represent the least mature technology and thus most in need of a parallel path for risk reduction. Also, while current CCD detectors would likely meet the mission needs for grating spectrum readout, specific improvements are included as an additional approach for achieving the grating system effective area requirement. The technical steps needed for these technologies to attain technology readiness levels (TRL) of 5 and 6 are described, as well as desirable modest risk reduction steps beyond TRL-6. All of the technology development efforts are currently funded through the NASA Physics of the Cosmos (PCOS) Strategic Astrophysics Technology (SAT) program; some through the end of FY13, others though FY14. These technology needs are those identified as critical for a near-term mission and briefly described in the 2012 NASA X-ray Mission Concepts Study. This Technology Development Roadmap (TDR) provides a more complete description of each, updates the status, and describes the steps to mature them. For each technology, a roadmap is presented for attaining TRL-6 by 2020 at the latest, and 2018 for most. The funding required for each technology to attain TRL-5 and TRL-6 is presented and justified through a description of the steps needing completion. The total funding required for these technologies to reach TRL-6 is relatively modest, and is consistent with the planned PCOS SAT funding over the next several years. The approximate annual cost through 2018 is $8M. The total cost for all technologies to be matured is $62M (including funding already awarded for FY13 and FY14). This can be contrasted to the $180M recommended by NWNH for technology development for IXO, primarily for the maturation of the mirror technology. The technology described in Section 3 of this document is exclusively that needed for a near-term Probe-class mission, to start in 2017, or for a mission that can be recommended by the next Decadal survey committee for an immediate start. It is important to note that there are other critical X-ray instrumentation technologies under development that are less mature than the ones discussed here, but are essential for a major X-ray mission that might start in the late 2020s. These technologies, described briefly in Section 4, are more appropriately funded through the Astronomy and Physics Research and Analysis (APRA) program.

An early-stage epidemic: a systematic review of correlates of smoking among Chinese women.

PubMed

Ding, Ding; Gebel, Klaus; Oldenburg, Brian F; Wan, Xia; Zhong, Xuefeng; Novotny, Thomas E

2014-08-01

Despite the historically low smoking prevalence among Chinese women, there is a trend of future increase. We systematically reviewed the correlates of smoking among Chinese girls and women. We conducted a systematic review of literature on correlates of smoking among Chinese women using Medline and China Academic Journals databases. Following the PRISMA statement, two investigators independently searched for literature, identified and reviewed papers, assessed the quality of the papers, and extracted information. The characteristics of studies and correlates of smoking were synthesized separately for youth and adults. A total of 15 articles (11 on adults, 4 on youth) met the inclusion criteria. Based on these studies, peer smoking was the most consistent correlate of smoking among Chinese girls. Among Chinese women, partner smoking, job-related stress, and exposure to cigarettes made for women were consistent correlates of smoking. Knowledge of harms and negative attitudes towards smoking were found to be negatively associated with smoking. Overall, the evidence base for smoking among Chinese women is limited. Although smoking among Chinese women is still at an early stage, it is becoming more prevalent among specific population subgroups, such as rural-to-urban migrant workers. Although further research is needed, findings from the current study provide a roadmap for research and policy on prevention of smoking among Chinese girls and women.

Co-creation of a digital tool for the empowerment of parents of children with physical disabilities.

PubMed

Alsem, M W; van Meeteren, K M; Verhoef, M; Schmitz, M J W M; Jongmans, M J; Meily-Visser, J M A; Ketelaar, M

2017-01-01

Parents of children with physical disabilities do a lot to support their child in daily life. In doing this they are faced with many challenges. These parents have a wide range of unmet needs, especially for information, on different topics. It is sometimes hard for them to get the right information at the right moment, and to ask the right questions to physicians and other healthcare professionals. In order to develop a digital tool to help parents formulate questions and find information, we thought it would be crucial to work together in a process of co-creation with parents, researchers, IT-specialists and healthcare professionals. In close collaboration with them we developed a tool that aims to help parents ask questions, find information and take a more leading role in consultations with healthcare professionals, called the WWW-roadmap (WWW-wijzer in Dutch).In two groups of parents (one group with and one group without experience of using the tool), we will study the effects of using this tool, on consultations with physicians. We expect that using the tool will result in better empowerment, satisfaction and family-centred care. Parents of children with physical disabilities do much to support their child in daily life. In doing so, they are faced with many challenges. These parents have a wide range of unmet needs, especially for information, on various topics. Getting timely and reliable information is very difficult for parents, whereas being informed is a major requirement for the process of empowerment and shared decision-making. This paper describes the development of a digital tool to support parents in this process. During its development, working together with parents was crucial to address relevant topics and design a user-centred intervention. In co-creation with parents, healthcare professionals, IT-professionals and researchers, a digital tool was developed, the 'WWW-roadmap' ['WWW-wijzer' in Dutch]. This digital tool aims to enable parents to explore their questions (What do I want to know?), help in their search for information (Where can I find the information I need), and refer to appropriate professionals (Who can assist me further?).During the process, we got extensive feedback from a parent panel consisting of parents of children with physical disabilities, enabling us to create the tool 'with' rather than 'for' them. This led to a user-friendly and problem-driven tool. The WWW-roadmap can function as a tool to help parents formulate their questions, search for information and thus prepare for consultations with healthcare professionals, and to facilitate parental empowerment and shared-decision making by parent and professional. Effects of using the WWW-roadmap on consultations with professionals will be studied in the future.

Roadmapping Future E-Government Research

NASA Astrophysics Data System (ADS)

Bicking, Melanie

Global electronic markets, virtual organisations, virtual identities, virtual products and services, and Internet-related crime are growing in prominence and importance. In a world that is increasingly non-physical and borderless, what are government's roles, responsibilities and limitations? The Internet plays a central role within the transformation process from traditional governments towards modern and innovative government that the requirements of an Information Society. Based on the findings of the eGovRTD2020 project, that aims at identifying key research challenges and at implementing a model for a holistic government with horizon 2020, this paper explains the necessity to investigate and understand the Internet and in particular government's role and responsibilities in it. Furthermore, the paper provides a research roadmap that details how to address certain issue related research questions.

Results of the Workshop on Two-Phase Flow, Fluid Stability and Dynamics: Issues in Power, Propulsion, and Advanced Life Support Systems

NASA Technical Reports Server (NTRS)

McQuillen, John; Rame, Enrique; Kassemi, Mohammad; Singh, Bhim; Motil, Brian

2003-01-01

The Two-phase Flow, Fluid Stability and Dynamics Workshop was held on May 15, 2003 in Cleveland, Ohio to define a coherent scientific research plan and roadmap that addresses the multiphase fluid problems associated with NASA s technology development program. The workshop participants, from academia, industry and government, prioritized various multiphase issues and generated a research plan and roadmap to resolve them. This report presents a prioritization of the various multiphase flow and fluid stability phenomena related primarily to power, propulsion, fluid and thermal management and advanced life support; and a plan to address these issues in a logical and timely fashion using analysis, ground-based and space-flight experiments.

The Stellar Imager (SI)"Vision Mission"

NASA Technical Reports Server (NTRS)

Carpenter, Ken; Danchi, W.; Leitner, J.; Liu, A.; Lyon, R.; Mazzuca, L.; Moe, R.; Chenette, D.; Karovska, M.; Allen, R.

2004-01-01

The Stellar Imager (SI) is a "Vision" mission in the Sun-Earth Connection (SEC) Roadmap, conceived for the purpose of understanding the effects of stellar magnetic fields, the dynamos that generate them, and the internal structure and dynamics of the stars in which they exist. The ultimate goal is to achieve the best possible forecasting of solar/stellar magnetic activity and its impact on life in the Universe. The science goals of SI require an ultra-high angular resolution, at ultraviolet wavelengths, on the order of 100 micro-arcsec and thus baselines on the order of 0.5 km. These requirements call for a large, multi-spacecraft (less than 20) imaging interferometer, utilizing precision formation flying in a stable environment, such as in a Lissajous orbit around the Sun-Earth L2 point. SI's resolution will make it an invaluable resource for many other areas of astrophysics, including studies of AGN s, supernovae, cataclysmic variables, young stellar objects, QSO's, and stellar black holes. ongoing mission concept and technology development studies for SI. These studies are designed to refine the mission requirements for the science goals, define a Design Reference Mission, perform trade studies of selected major technical and architectural issues, improve the existing technology roadmap, and explore the details of deployment and operations, as well as the possible roles of astronauts and/or robots in construction and servicing of the facility.

Cloud Computing for Mission Design and Operations

NASA Technical Reports Server (NTRS)

Arrieta, Juan; Attiyah, Amy; Beswick, Robert; Gerasimantos, Dimitrios

2012-01-01

The space mission design and operations community already recognizes the value of cloud computing and virtualization. However, natural and valid concerns, like security, privacy, up-time, and vendor lock-in, have prevented a more widespread and expedited adoption into official workflows. In the interest of alleviating these concerns, we propose a series of guidelines for internally deploying a resource-oriented hub of data and algorithms. These guidelines provide a roadmap for implementing an architecture inspired in the cloud computing model: associative, elastic, semantical, interconnected, and adaptive. The architecture can be summarized as exposing data and algorithms as resource-oriented Web services, coordinated via messaging, and running on virtual machines; it is simple, and based on widely adopted standards, protocols, and tools. The architecture may help reduce common sources of complexity intrinsic to data-driven, collaborative interactions and, most importantly, it may provide the means for teams and agencies to evaluate the cloud computing model in their specific context, with minimal infrastructure changes, and before committing to a specific cloud services provider.

Multiscale crack initiator promoted super-low ice adhesion surfaces.

PubMed

He, Zhiwei; Xiao, Senbo; Gao, Huajian; He, Jianying; Zhang, Zhiliang

2017-09-27

Preventing icing on exposed surfaces is important for life and technology. While suppressing ice nucleation by surface structuring and local confinement is highly desirable and yet to be achieved, a realistic roadmap of icephobicity is to live with ice, but with lowest possible ice adhesion. According to fracture mechanics, the key to lower ice adhesion is to maximize crack driving forces at the ice-substrate interface. Herein, we present a novel integrated macro-crack initiator mechanism combining nano-crack and micro-crack initiators, and demonstrate a new approach to designing super-low ice adhesion surfaces by introducing sub-structures into smooth polydimethylsiloxane coatings. Our design promotes the initiation of macro-cracks and enables the reduction of ice adhesion by at least ∼50% regardless of the curing temperature, weight ratio and size of internal holes, reaching a lowest ice adhesion of 5.7 kPa. The multiscale crack initiator mechanisms provide an unprecedented and versatile strategy towards designing super-low ice adhesion surfaces.

Fault Management Practice: A Roadmap for Improvement

NASA Technical Reports Server (NTRS)

Fesq, Lorraine M.; Oberhettinger, David

2010-01-01

Autonomous fault management (FM) is critical for deep space and planetary missions where the limited communication opportunities may prevent timely intervention by ground control. Evidence of pervasive architecture, design, and verification/validation problems with NASA FM engineering has been revealed both during technical reviews of spaceflight missions and in flight. These problems include FM design changes required late in the life-cycle, insufficient project insight into the extent of FM testing required, unexpected test results that require resolution, spacecraft operational limitations because certain functions were not tested, and in-flight anomalies and mission failures attributable to fault management. A recent NASA initiative has characterized the FM state-of-practice throughout the spacecraft development community and identified common NASA, DoD, and commercial concerns that can be addressed in the near term through the development of a FM Practitioner's Handbook and the formation of a FM Working Group. Initial efforts will focus on standardizing FM terminology, establishing engineering processes and tools, and training.

The Orbital Debris Problem and the Challenges for Environment Remediation

NASA Technical Reports Server (NTRS)

Liou, J.-C.

2014-01-01

LEO debris population will continue to increase even with a good implementation of the commonly-adopted mitigation measures. The root-cause of the increase is catastrophic collisions involving large/massive intact objects (rocket bodies or spacecraft). The major mission-ending risks for most operational spacecraft, however, come from impacts with debris just above the threshold of the protection shields (5-mm to 1-cm). A solution-driven approach is to seek: Concepts for removal of massive intacts with high P(collision); Concepts capable of preventing collisions involving intacts; Concepts for removal of 5-mm to 1-cm debris; Enhanced impact protection shields for valuable space assets. Key questions for remediation consideration of orbital debris: What is the acceptable threat level? What are the mission objectives? What is the appropriate roadmap/timeframe for remediation? Support advanced technology development when an economically viable approach is identified. Address non-technical issues, such as policy, coordination, ownership, legal, and liability at the national and international levels.

DDR Memories

NASA Technical Reports Server (NTRS)

Wyrwas, Edward J.

2017-01-01

This presentation will include information about Double Data Rate (DDR) technology, NASA Electronic Parts and Packaging (NEPP) tasks and their purpose, collaborations, a roadmap, NEPP partners, results to date, and future plans.

A stochastic dynamic model for human error analysis in nuclear power plants

NASA Astrophysics Data System (ADS)

Delgado-Loperena, Dharma

Nuclear disasters like Three Mile Island and Chernobyl indicate that human performance is a critical safety issue, sending a clear message about the need to include environmental press and competence aspects in research. This investigation was undertaken to serve as a roadmap for studying human behavior through the formulation of a general solution equation. The theoretical model integrates models from two heretofore-disassociated disciplines (behavior specialists and technical specialists), that historically have independently studied the nature of error and human behavior; including concepts derived from fractal and chaos theory; and suggests re-evaluation of base theory regarding human error. The results of this research were based on comprehensive analysis of patterns of error, with the omnipresent underlying structure of chaotic systems. The study of patterns lead to a dynamic formulation, serving for any other formula used to study human error consequences. The search for literature regarding error yielded insight for the need to include concepts rooted in chaos theory and strange attractors---heretofore unconsidered by mainstream researchers who investigated human error in nuclear power plants or those who employed the ecological model in their work. The study of patterns obtained from the rupture of a steam generator tube (SGTR) event simulation, provided a direct application to aspects of control room operations in nuclear power plant operations. In doing so, the conceptual foundation based in the understanding of the patterns of human error analysis can be gleaned, resulting in reduced and prevent undesirable events.

VIIP Bedrest Analog Roadmap

NASA Technical Reports Server (NTRS)

Villarreal, Jennifer D.

2014-01-01

The objective is to define successive bed rest campaigns leading to a potential VIIP (Vision Impairment and Intracranial Pressure) countermeasure. To determine if the analog is successful, changes need to occur in the following outcome measures (dependent variables): Intracranial pressure; Retinal nerve fiber layer; Choroidal engorgement; Globe flattening; Axial biometry; Optic nerve sheath diameter distention; Cycloplegic refraction; Visual acuity. Study parameters (independent variables) to include: CO2; Sodium; Exercise (resistive & aerobic); Strict tilt angle.

Avionics Collaborative Engineering Technology Delivery Order 0035: Secure Knowledge Management (SKM) Technology Research Roadmap - Technology Trends for Collaborative Information and Knowledge Management Research

DTIC Science & Technology

2004-06-01

such as that represented in the know-how of the master craftsman), and cognitive (know why, perceptions, values, beliefs, and mental models).4... cognitive engineering, educational technology, industrial/organizational psychology, sociology, cultural anthropology, and computational...such as human-human interaction, interface design and evaluation methodology, cognitive models and user models, health and ergonomic studies, empirical

Developing Systems Engineering Experience Accelerator (SEEA) Prototype and Roadmap -- Increment 4

DTIC Science & Technology

2017-08-08

of an acquisition program, two categories of new capabilities were added to the UAV experience. Based on a student project at Stevens Institute of...program for a new unmanned aerial vehicle (UAV) system. It was based on the concept of the learners assuming this role shortly after preliminary...University curriculum for systems engineers. First, several new capabilities have been added. These include a trade study for additional technical

Rapid Prototyping of Application Specific Signal Processors (RASSP) program - Study Phase

DTIC Science & Technology

1992-10-12

in the quantitative evaluaion of desip ltenatlves. To make sysmms such as IDAS mor effective for...steps, and should invest in the standardization of data models that meet these needs. PDES and CFI are likely to offer the most payoff for such an...provides a bigger picture of the ATR roadmap. It attempts to lay out the projected progress of the ATR technologies and applications, both in the

Autonomous Mission Operations Roadmap

NASA Technical Reports Server (NTRS)

Frank, Jeremy David

2014-01-01

As light time delays increase, the number of such situations in which crew autonomy is the best way to conduct the mission is expected to increase. However, there are significant open questions regarding which functions to allocate to ground and crew as the time delays increase. In situations where the ideal solution is to allocate responsibility to the crew and the vehicle, a second question arises: should the activity be the responsibility of the crew or an automated vehicle function? More specifically, we must answer the following questions: What aspects of mission operation responsibilities (Plan, Train, Fly) should be allocated to ground based or vehicle based planning, monitoring, and control in the presence of significant light-time delay between the vehicle and the Earth?How should the allocated ground based planning, monitoring, and control be distributed across the flight control team and ground system automation? How should the allocated vehicle based planning, monitoring, and control be distributed between the flight crew and onboard system automation?When during the mission should responsibility shift from flight control team to crew or from crew to vehicle, and what should the process of shifting responsibility be as the mission progresses? NASA is developing a roadmap of capabilities for Autonomous Mission Operations for human spaceflight. This presentation will describe the current state of development of this roadmap, with specific attention to in-space inspection tasks that crews might perform with minimum assistance from the ground.

Reliable, Practical Kilowatt-class Cryogenics for Superconducting Devices

DOE Office of Scientific and Technical Information (OSTI.GOV)

Spoor, Philip

2016-12-15

Following the successful development of a Flexibly-Attached Remote cryocooler for ~200W at 80K under a Phase II DOE grant, Clever Fellows Innovation Consortium, Inc. (dba CFIC-Qdrive; acquired by Chart Industries in 2012) was invited by the DOE to scale up this technology to ~1000W/80K in a Phase III program. This target is responsive to the “Cryogenics Roadmap” developed by the DOE to accelerate the development of cryogenic cooling necessary to support the emerging superconducting power applications. Mirroring the Roadmap, our proposal included a capacity target (1000W at 80K) and a cost target (<$40/watt, at 80K), but unlike the Roadmap, wemore » did not formally propose to meet a specific efficiency target. We achieved 75% of the capacity target, with a record-size coaxial “pulse-tube” coldfinger, but only by working on the project well beyond the original “period of performance” on unfunded extension. We believe 100% of the capacity target was within reach, but our own budget and time constraints forbade additional effort. We were less successful in meeting the cost targets. Ultimately, the specific configuration that was the subject of Phase III was not commercialized, largely because the market for superconducting devices has not been nearly as robust as was expected at the advent of the Roadmap.« less

The biomarker-based diagnosis of Alzheimer's disease. 1-ethical and societal issues.

PubMed

Porteri, Corinna; Albanese, Emiliano; Scerri, Charles; Carrillo, Maria C; Snyder, Heather M; Martensson, Birgitta; Baker, Mark; Giacobini, Ezio; Boccardi, Marina; Winblad, Bengt; Frisoni, Giovanni B; Hurst, Samia

2017-04-01

There is great interest in the use of biomarkers to assist in the timely identification of Alzheimer's disease (AD) in individuals with mild symptoms. However, the inclusion of AD biomarkers in clinical criteria poses socioethical challenges. The Geneva Task Force for the Roadmap of Alzheimer's Biomarkers was established to deliver a systematic strategic research agenda (aka roadmap) to promote efficient and effective validation of AD biomarkers and to foster their uptake in clinical practice. In this article, we summarize the workshop discussion of the Geneva Task Force "ethical and societal issues" working group, which comprised bioethicists, clinicians, health economists, and representatives of those affected by AD. The working group identified the following key issues that need to be included in the roadmap: improving access to services through timely diagnosis, the need for a diagnostic research protocol before moving to clinical routine, recruitment in diagnostic research protocols in the absence of effective therapy, respect for the autonomy of the individual with mild cognitive impairment in information and consent process and the right not to know biomarkers results, need for counseling programs, disclosure of the diagnosis in a structured environment and the involvement of family members, health policies including the individuals' views and the protection of their interests, and the economic costs for society. Copyright © 2016 Elsevier Inc. All rights reserved.

Crossing the chasm: information technology to biomedical informatics.

PubMed

Fahy, Brenda G; Balke, C William; Umberger, Gloria H; Talbert, Jeffery; Canales, Denise Niles; Steltenkamp, Carol L; Conigliaro, Joseph

2011-06-01

Accelerating the translation of new scientific discoveries to improve human health and disease management is the overall goal of a series of initiatives integrated in the National Institutes of Health (NIH) "Roadmap for Medical Research." The Clinical and Translational Science Award (CTSA) program is, arguably, the most visible component of the NIH Roadmap providing resources to institutions to transform their clinical and translational research enterprises along the goals of the Roadmap. The CTSA program emphasizes biomedical informatics as a critical component for the accomplishment of the NIH's translational objectives. To be optimally effective, emerging biomedical informatics programs must link with the information technology platforms of the enterprise clinical operations within academic health centers.This report details one academic health center's transdisciplinary initiative to create an integrated academic discipline of biomedical informatics through the development of its infrastructure for clinical and translational science infrastructure and response to the CTSA mechanism. This approach required a detailed informatics strategy to accomplish these goals. This transdisciplinary initiative was the impetus for creation of a specialized biomedical informatics core, the Center for Biomedical Informatics (CBI). Development of the CBI codified the need to incorporate medical informatics including quality and safety informatics and enterprise clinical information systems within the CBI. This article describes the steps taken to develop the biomedical informatics infrastructure, its integration with clinical systems at one academic health center, successes achieved, and barriers encountered during these efforts.

2013 Snapshot of NGSI Human Capital Development and Future Roadmap

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scholz, Melissa A; Poe, Sarah M; Dewji, Shaheen A

2013-01-01

Since its creation in 2008, the Human Capital Development (HCD) subprogram of NNSA s Next Generation Safeguards Initiative (NGSI) has been striving to develop sustainable academic and technical programs that support the recruitment, education, training, and retention of the next generation of international safeguards professionals. This effort endeavors to develop additional human resources to equip a new cadre of safeguards and nonproliferation experts to meet the needs of both the United States and the International Atomic Energy Agency (IAEA) for decades to come, specifically in response to data that indicates that 82% of the 2009 safeguards experts at U.S. Laboratoriesmore » will have left the workforce within 15 years. This paper provides an update on the status of the program since its last presentation at the INMM Annual Meeting in 2010, including strengthened and integrated efforts in the areas of graduate and post-doctoral fellowships, young and mid-career professional support, additional short safeguards coursework, and expanded university engagement. In particular, the paper will cover the NGSI Human Capital Roadmap currently being developed in safeguards and nonproliferation education, training, and knowledge retention. The NGSI Human Capital Roadmap aims to provide additional data points and metrics on where the human capital demand lies, which disciplines and skill sets are needed in the field, and how NGSI HCD can best address these issues to meet future demand.« less

Common challenge, collaborative response: a roadmap for US-China cooperation on energy and climate change

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

2009-01-15

This Report which was produced in partnership between Asia Society's Center on U.S.-China Relations and Pew Center on Global Climate Change, in collaboration with The Brookings Institution, Council on Foreign Relations, National Committee on U.S.-China Relations, and Environmental Defense Fund presents both a vision and a concrete Roadmap for such Sino-U.S. collaboration. With input from scores of experts and other stakeholders from the worlds of science, business, civil society, policy, and politics in both China and the United States, the Report, or 'Roadmap', explores the climate and energy challenges facing both nations and recommends a concrete program for sustained, high-level,more » bilateral engagement and on-the-ground action. The Report recommends that, as a first step in forging this new partnership, the leaders of the two countries should convene a leaders summit as soon as practically possible following the inauguration of Barack Obama to launch a 'U.S.-China Partnership on Energy and Climate Change'. This presidential summit should outline a major plan of joint-action and empower relevant officials in each country to take the necessary actions to ensure its implementation. Priority areas of collaboration include: deploying low-emissions coal technologies; improving energy efficiency and conservation; developing an advanced electric grid; promoting renewable energy; and quantifying emissions and financing low-carbon technologies. 5 figs., 1 tab., 2 apps.« less

Breaking the Glass Ceiling in Oklahoma Higher Education: A Case Study of Kate Galt Zaneis, the First Woman President of a Public Four-Year College or University in the United States

ERIC Educational Resources Information Center

Smarr, Debbie L.

2011-01-01

Women's leadership within higher education continues to be the focus of research and essays. A look into the lives of past women leaders in higher education can provide a potential "road-map" for aspiring women to follow as they develop their leadership style to aid in their upward mobility. The study of the first woman to lead a public…

Open innovation in early drug discovery: roadmaps and roadblocks.

PubMed

Reichman, Melvin; Simpson, Peter B

2016-05-01

Open innovation in pharmaceutical R&D evolved from a triple helix of convergent paradigm shifts in academic, industrial and government research sectors. The birth of the biotechnology sector catalyzed shifts in location dynamics that led to the first wave of open innovation in pharmaceutical R&D between big pharma and startup companies. The National Institutes of Health (NIH) Roadmap was a crucial inflection point that set the stage for a new wave of open innovation models between pharmaceutical companies and universities that have the potential to transform the pharmaceutical R&D landscape. We highlight the attributes of leading protected open innovation models that foster the sharing of proprietary small molecule collections by lowering the risk of premature escape of intellectual property, particularly structure-activity data. Copyright © 2015 Elsevier Ltd. All rights reserved.

Army Net Zero: Energy Roadmap and Program Summary, Fiscal Year 2013 (Brochure)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

The U.S. Army (Army) partnered with the National Renewable Energy Laboratory (NREL) and the U.S. Army Corps of Engineers to assess opportunities for increasing energy security through improved energy efficiency and optimized renewable energy strategies at nine installations across the Army's portfolio. Referred to as Net Zero Energy Installations (NZEIs), these projects demonstrate and validate energy efficiency and renewable energy technologies with approaches that can be replicated across DOD and other Federal agencies, setting the stage for broad market adoption. This report summarizes the results of the energy project roadmaps developed by NREL, shows the progress each installation could makemore » in achieving Net Zero Energy by 2020, and presents lessons learned and unique challenges from each installation.« less

NeuroRex: A Clinical Neural Interface Roadmap for EEG-based Brain Machine Interfaces to a Lower Body Robotic Exoskeleton*

PubMed Central

Contreras-Vidal, Jose L.; Grossman, Robert G.

2013-01-01

In this communication, a translational clinical brain-machine interface (BMI) roadmap for an EEG-based BMI to a robotic exoskeleton (NeuroRex) is presented. This multi-faceted project addresses important engineering and clinical challenges: It addresses the validation of an intelligent, self-balancing, robotic lower-body and trunk exoskeleton (Rex) augmented with EEG-based BMI capabilities to interpret user intent to assist a mobility-impaired person to walk independently. The goal is to improve the quality of life and health status of wheelchair-bounded persons by enabling standing and sitting, walking and backing, turning, ascending and descending stairs/curbs, and navigating sloping surfaces in a variety of conditions without the need for additional support or crutches. PMID:24110003

Overview and Status of the Bioastronautics Critical Path Roadmap (BCPR)

NASA Technical Reports Server (NTRS)

Charles, John

2004-01-01

Viewgraphs on the status and overview of the Bioastronautics Critical Path Roadmap (BCPR) are presented. The topics include: 1) BCPR Objectives; 2) BCPR and OBPR Program Management; 3) BCPR Disciplines & Cross-Cutting Areas; 4) Characteristics of BCPR Reference Missions; 5) Bioastronautics Timetable (notional); 6) BCPR Processes Risk Identification, Assessment, and Management; 7) Types of BCPR Risks; 8) Enabling Questions Categories; 9) Risk Mitigation Status; 10) Defining Levels of Accepted Risk; 11) BCPR Integration; 12) BCPR Implementation, Integration, and Validation; 13) BCPR Refinement Schedule; 14) Academy Review; 15) Rating Bioastronautics Risks; 16) Risk Rating Exercises; 17) Human Health Risk Assessment Criteria (examples); 18) A Recent Risk Rating Exercise; 19) Consensus Workshop Background; 20) Consensus Workshop Rating Analysis; 21) Consensus Workshop Selected Preliminary Recommendations; and 22) Access to BCPR Content.

Solar Technology Roadmap Act

THOMAS, 111th Congress

Rep. Giffords, Gabrielle [D-AZ-8

2009-09-16

Senate - 12/08/2009 Committee on Energy and Natural Resources Subcommittee on Energy. Hearings held. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

Space Life Sciences at NASA: Spaceflight Health Policy and Standards

NASA Technical Reports Server (NTRS)

Davis, Jeffrey R.; House, Nancy G.

2006-01-01

In January 2005, the President proposed a new initiative, the Vision for Space Exploration. To accomplish the goals within the vision for space exploration, physicians and researchers at Johnson Space Center are establishing spaceflight health standards. These standards include fitness for duty criteria (FFD), permissible exposure limits (PELs), and permissible outcome limits (POLs). POLs delineate an acceptable maximum decrement or change in a physiological or behavioral parameter, as the result of exposure to the space environment. For example cardiovascular fitness for duty standards might be a measurable clinical parameter minimum that allows successful performance of all required duties. An example of a permissible exposure limit for radiation might be the quantifiable limit of exposure over a given length of time (e.g. life time radiation exposure). An example of a permissible outcome limit might be the length of microgravity exposure that would minimize bone loss. The purpose of spaceflight health standards is to promote operational and vehicle design requirements, aid in medical decision making during space missions, and guide the development of countermeasures. Standards will be based on scientific and clinical evidence including research findings, lessons learned from previous space missions, studies conducted in space analog environments, current standards of medical practices, risk management data, and expert recommendations. To focus the research community on the needs for exploration missions, NASA has developed the Bioastronautics Roadmap. The Bioastronautics Roadmap, NASA's approach to identification of risks to human space flight, revised baseline was released in February 2005. This document was reviewed by the Institute of Medicine in November 2004 and the final report was received in October 2005. The roadmap defines the most important research and operational needs that will be used to set policy, standards (define acceptable risk), and implement an overall Risk Management and Analysis process. Currently NASA is drafting spaceflight health standards for neurosensory alterations, space radiation exposure, behavioral health, muscle atrophy, cardiovascular fitness, immunological compromise, bone demineralization, and nutrition.

A process evaluation of a return-to-work intervention to improve Cooperation between Sick-listed employees and their Supervisors (COSS).

PubMed

Hoefsmit, Nicole; Boumans, Nicolle; Houkes, Inge; Nijhuis, Frans

2016-11-22

This is a process evaluation of an intervention to improve Cooperation regarding return-to-work (RTW) between sick-listed employees and their supervisors (COSS, which consists of a conversation roadmap, monitoring of cooperation using questionnaires and, if necessary, extra support by an occupational physician (OP). Objectives were to study (1) the adoption of COSS by a banking organization and (2) its implementation among individual employees, supervisors and OPs. We used quantitative data (online questionnaire, project administration, conversation minutes, emails) and qualitative data (semi-structured interviews). We analyzed quantitative data descriptively (by calculating sum scores, percentages, mean scores and standard deviations). The coding system to analyze the qualitative data was data-driven. The organization's representatives reported positively (e.g. fit with existing policy) and negatively (e.g. high intensity) about COSS. At least one OP (out of five) used the monitoring information. Project administration data show a modest reach of COSS among employees and supervisors. The roadmap was used by a minority (35% of the employees and 25% of the supervisors). Relatively many (40% of the employees and 100% of the supervisors who used COSS to evaluate conversations) were satisfied with COSS as a  tool to evaluate conversations with the employee/supervisor afterwards. Interview results indicate that the roadmap was considered useful in specific situations (e.g. psychological complaints). All employees and supervisors participated in the monitoring. The majority of the responding employees and supervisors received OP support and was satisfied about this support. Despite the good adoption of COSS by the organisation, it was only partially implemented by professionals, employees and supervisors. We hypothesize that our implementation approach did not fit completely with the culture at the bank. Also, the results illustrate the need for other intervention methods for improving cooperation between employees and supervisors and a more specific target population.

Heliophysics: The New Science of the Sun-Solar System Connection. Recommended Roadmap for Science and Technology 2005-2035

NASA Technical Reports Server (NTRS)

2005-01-01

This is a Roadmap to understanding the environment of our Earth, from its life-sustaining Sun out past the frontiers of the solar system. A collection of spacecraft now patrols this space, revealing not a placid star and isolated planets, but an immense, dynamic, interconnected system within which our home planet is embedded and through which space explorers must journey. These spacecraft already form a great observatory with which the Heliophysics program can study the Sun, the heliosphere, the Earth, and other planetary environments as elements of a system--one that contains dynamic space weather and evolves in response to solar, planetary, and interstellar variability. NASA continually evolves the Heliophysics Great Observatory by adding new missions and instruments in order to answer the challenging questions confronting us now and in the future as humans explore the solar system. The three heliophysics science objectives: opening the frontier to space environment prediction; understanding the nature of our home in space, and safeguarding the journey of exploration, require sustained research programs that depend on combining new data, theory, analysis, simulation, and modeling. Our program pursues a deeper understanding of the fundamental physical processes that underlie the exotic phenomena of space.

NASA's Microgravity Fluid Physics Strategic Research Roadmap

NASA Technical Reports Server (NTRS)

Motil, Brian J.; Singh, Bhim S.

2004-01-01

The Microgravity Fluid Physics Program at NASA has developed a substantial investigator base engaging a broad crosssection of the U.S. scientific community. As a result, it enjoys a rich history of many significant scientific achievements. The research supported by the program has produced many important findings that have been published in prestigious journals such as Science, Nature, Journal of Fluid Mechanics, Physics of Fluids, and many others. The focus of the program so far has primarily been on fundamental scientific studies. However, a recent shift in emphasis at NASA to develop advanced technologies to enable future exploration of space has provided motivation to add a strategic research component to the program. This has set into motion a year of intense planning within NASA including three workshops to solicit inputs from the external scientific community. The planning activities and the workshops have resulted in a prioritized list of strategic research issues along with a corresponding detailed roadmap specific to fluid physics. The results of these activities were provided to NASA s Office of Biological and Physical Research (OBPR) to support the development of the Enterprise Strategy document. This paper summarizes these results while showing how the planned research supports NASA s overall vision through OBPR s organizing questions.

Understanding BIM Adoption in the AEC Industry: The Case of Jordan

NASA Astrophysics Data System (ADS)

Btoush, M.; Haron, AT

2017-11-01

Building information modelling (BIM) is a new and powerful technology implemented by many countries. The construction industry in Jordan plays a vital role and contributes immensely to the economic growth and development. In order to boost the industry and the economy, many industry players including engineers and contractors have recommended the implementation of BIM in Jordan. However, research demonstrates that successful BIM implementation is possible through the awareness of the different levels of BIM, which is a basic precondition for BIM implementation. Without a clear understanding of BIM, many companies would be unable to fully achieve BIM potentials or implement BIM in their building lifecycle. The objective of this study is to assess the current awareness of BIM technology in the Jordanian construction industry. A field interviews were conducted and 15 responses were collected and. The findings indicate that a significant proportion of respondents have little or no understanding of the concept of BIM. Also, the usage was found to be very low. Based on the results, a holistic roadmap was developed to spread the BIM adoption through the Jordanian construction industry. It is expected that this roadmap would lead to a better understanding and enable the industry towards more extensive implementation of BIM.

Hull, Mechanical & Electrical (HM &E) Roadmap: Revolutionizing Naval Warfare and Achieving Energy Security

DTIC Science & Technology

2012-01-01

Further, recent economic studies have employed full-cost accounting methods ( Kaplan 2011) to estimate the costs force projection in the Persian...Type 45 Destroyer with an IPS and the Type 23 Frigate powered by the Combined Diesel- Electric and Gas Turbine (CODLAG) architecture provides an...Ammunition Ship and the Combined Diesel- Electric or Gas Turbine (CODLOG) (also known as hybrid gas- turbine -electric drive) aboard the USS MAKIN ISLAND

Technology Assessment and Roadmap for the Emergency Radiation Dose Assessment Program (ERDAP)

DTIC Science & Technology

2005-06-01

l2O3:C OSL dosimeters . Overall design is based on similar systems described earlier by Justus et al. (1999) and Huston et al. (2001). Similar apparatus...Radioisotope Contamination 4. Pre-Positioned Physical Dosimeters C. Assessment of Emerging Dosimetry Technologies 1. Biological Measurements 2. Physico...architectures for radiation dose assessment tools. • Focus initial studies on defining the role of pre-positioned dosimeters , optimizing the size and

Electronic Design Automation (EDA) Roadmap Taskforce Report, Design of Microprocessors

DTIC Science & Technology

1999-04-01

through on time. Hence, the study is not a crystal-ball- gazing exercise, but a rigorous, schedulable plan of action to attain the goal. NTRS97...formats so as not to impose too heavy a maintenance burden on their users Object Interfaces eliminate these problems: • A tool that binds the interface ...and User Interface - Design Tool Communication - EDA System Extension Language - EDA Standards- Based Software Development Environment - Design and

Analysis of good practices, barriers and drivers for ELTs pyrolysis industrial application.

PubMed

Zabaniotou, A; Antoniou, N; Bruton, G

2014-11-01

Boosting of eco-innovative solutions for End of Life Tyres (ELTs) management, under the principles of the EU Resource Efficiency Roadmap and the Waste Framework Directive, can not only diminish the environmental hazards and the consequent societal cost, but also result to the establishment of a novel perception regarding ELTs; thus, a valuable stock of resources that can be exploited. Despite the extensive scientific research of the previous years on ELTs depolymerisation via pyrolysis highlighting its eco-innovative characteristics, the use of pyrolysis to process scrap tyres has not yet achieved a broad commercial success, with economic viability and product standardization to constitute the primary impediments. More specifically, pyrolysis was not applied to an extensive industrial scale so far, due to deficient market analysis, legislative barriers, economic instability and sometimes public acceptance. All the above issues are addressed by the present study. Modifications on current EU legislation can prevent or reduce delays or derailment of efforts on pyrolysis, through its differentiation from incineration. The attainment of economic viability could be realized through the valorization of the pyrolytic char towards activated carbon production for environmental depollution applications; needless to say, the penetration on niche and well-organised markets is more than essential. Copyright © 2014 Elsevier Ltd. All rights reserved.

Genetic determinants of cardiometabolic risk: a proposed model for phenotype association and interaction.

PubMed

Blackett, Piers R; Sanghera, Dharambir K

2013-01-01

This review provides a translational and unifying summary of metabolic syndrome genetics and highlights evidence that genetic studies are starting to unravel and untangle origins of the complex and challenging cluster of disease phenotypes. The associated genes effectively express in the brain, liver, kidney, arterial endothelium, adipocytes, myocytes, and β cells. Progression of syndrome traits has been associated with ectopic lipid accumulation in the arterial wall, visceral adipocytes, myocytes, and liver. Thus, it follows that the genetics of dyslipidemia, obesity, and nonalcoholic fatty liver disease are central in triggering progression of the syndrome to overt expression of disease traits and have become a key focus of interest for early detection and for designing prevention and treatments. To support the "birds' eye view" approach, we provide a road-map depicting commonality and interrelationships between the traits and their genetic and environmental determinants based on known risk factors, metabolic pathways, pharmacologic targets, treatment responses, gene networks, pleiotropy, and association with circadian rhythm. Although only a small portion of the known heritability is accounted for and there is insufficient support for clinical application of gene-based prediction models, there is direction and encouraging progress in a rapidly moving field that is beginning to show clinical relevance. Copyright © 2013 National Lipid Association. Published by Elsevier Inc. All rights reserved.

Genetic Determinants of Cardio-Metabolic Risk: A Proposed Model for Phenotype Association and Interaction

PubMed Central

Blackett, Piers R; Sanghera, Dharambir K

2012-01-01

This review provides a translational and unifying summary of metabolic syndrome genetics and highlights evidence that genetic studies are starting to unravel and untangle origins of the complex and challenging cluster of disease phenotypes. The associated genes effectively express in the brain, liver, kidney, arterial endothelium, adipocytes, myocytes and β cells. Progression of syndrome traits has been associated with ectopic lipid accumulation in the arterial wall, visceral adipocytes, myocytes, and liver. Thus it follows that the genetics of dyslipidemia, obesity, and non-alcoholic fatty liver (NAFLD) disease are central in triggering progression of the syndrome to overt expression of disease traits, and have become a key focus of interest for early detection and for designing prevention and treatments. To support the “birds’ eye view” approach we provide a road-map depicting commonality and interrelationships between the traits and their genetic and environmental determinants based on known risk factors, metabolic pathways, pharmacological targets, treatment responses, gene networks, pleiotropy, and association with circadian rhythm. Although only a small portion of the known heritability is accounted for and there is insufficient support for clinical application of gene-based prediction models, there is direction and encouraging progress in a rapidly moving field that is beginning to show clinical relevance. PMID:23351585

The 2017 terahertz science and technology roadmap

DOE PAGES

Dhillon, S. S.; Vitiello, M. S.; Linfield, E. H.; ...

2017-01-04

Science and technologies based on terahertz frequency electromagnetic radiation (100 GHz–30 THz) have developed rapidly over the last 30 years. For most of the 20th Century, terahertz radiation, then referred to as sub-millimeter wave or far-infrared radiation, was mainly utilized by astronomers and some spectroscopists. Following the development of laser based terahertz time-domain spectroscopy in the 1980s and 1990s the field of THz science and technology expanded rapidly, to the extent that it now touches many areas from fundamental science to 'real world' applications. For example THz radiation is being used to optimize materials for new solar cells, and maymore » also be a key technology for the next generation of airport security scanners. While the field was emerging it was possible to keep track of all new developments, however now the field has grown so much that it is increasingly difficult to follow the diverse range of new discoveries and applications that are appearing. At this point in time, when the field of THz science and technology is moving from an emerging to a more established and interdisciplinary field, it is apt to present a roadmap to help identify the breadth and future directions of the field. The aim of this roadmap is to present a snapshot of the present state of THz science and technology in 2017, and provide an opinion on the challenges and opportunities that the future holds. To be able to achieve this aim, we have invited a group of international experts to write 18 sections that cover most of the key areas of THz science and technology. We hope that The 2017 Roadmap on THz science and technology will prove to be a useful resource by providing a wide ranging introduction to the capabilities of THz radiation for those outside or just entering the field as well as providing perspective and breadth for those who are well established. Lastly, we also feel that this review should serve as a useful guide for government and funding agencies.« less

The 2017 terahertz science and technology roadmap

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dhillon, S. S.; Vitiello, M. S.; Linfield, E. H.

Science and technologies based on terahertz frequency electromagnetic radiation (100 GHz–30 THz) have developed rapidly over the last 30 years. For most of the 20th Century, terahertz radiation, then referred to as sub-millimeter wave or far-infrared radiation, was mainly utilized by astronomers and some spectroscopists. Following the development of laser based terahertz time-domain spectroscopy in the 1980s and 1990s the field of THz science and technology expanded rapidly, to the extent that it now touches many areas from fundamental science to 'real world' applications. For example THz radiation is being used to optimize materials for new solar cells, and maymore » also be a key technology for the next generation of airport security scanners. While the field was emerging it was possible to keep track of all new developments, however now the field has grown so much that it is increasingly difficult to follow the diverse range of new discoveries and applications that are appearing. At this point in time, when the field of THz science and technology is moving from an emerging to a more established and interdisciplinary field, it is apt to present a roadmap to help identify the breadth and future directions of the field. The aim of this roadmap is to present a snapshot of the present state of THz science and technology in 2017, and provide an opinion on the challenges and opportunities that the future holds. To be able to achieve this aim, we have invited a group of international experts to write 18 sections that cover most of the key areas of THz science and technology. We hope that The 2017 Roadmap on THz science and technology will prove to be a useful resource by providing a wide ranging introduction to the capabilities of THz radiation for those outside or just entering the field as well as providing perspective and breadth for those who are well established. Lastly, we also feel that this review should serve as a useful guide for government and funding agencies.« less

The 2017 terahertz science and technology roadmap

NASA Astrophysics Data System (ADS)

Dhillon, S. S.; Vitiello, M. S.; Linfield, E. H.; Davies, A. G.; Hoffmann, Matthias C.; Booske, John; Paoloni, Claudio; Gensch, M.; Weightman, P.; Williams, G. P.; Castro-Camus, E.; Cumming, D. R. S.; Simoens, F.; Escorcia-Carranza, I.; Grant, J.; Lucyszyn, Stepan; Kuwata-Gonokami, Makoto; Konishi, Kuniaki; Koch, Martin; Schmuttenmaer, Charles A.; Cocker, Tyler L.; Huber, Rupert; Markelz, A. G.; Taylor, Z. D.; Wallace, Vincent P.; Axel Zeitler, J.; Sibik, Juraj; Korter, Timothy M.; Ellison, B.; Rea, S.; Goldsmith, P.; Cooper, Ken B.; Appleby, Roger; Pardo, D.; Huggard, P. G.; Krozer, V.; Shams, Haymen; Fice, Martyn; Renaud, Cyril; Seeds, Alwyn; Stöhr, Andreas; Naftaly, Mira; Ridler, Nick; Clarke, Roland; Cunningham, John E.; Johnston, Michael B.

2017-02-01

Science and technologies based on terahertz frequency electromagnetic radiation (100 GHz-30 THz) have developed rapidly over the last 30 years. For most of the 20th Century, terahertz radiation, then referred to as sub-millimeter wave or far-infrared radiation, was mainly utilized by astronomers and some spectroscopists. Following the development of laser based terahertz time-domain spectroscopy in the 1980s and 1990s the field of THz science and technology expanded rapidly, to the extent that it now touches many areas from fundamental science to ‘real world’ applications. For example THz radiation is being used to optimize materials for new solar cells, and may also be a key technology for the next generation of airport security scanners. While the field was emerging it was possible to keep track of all new developments, however now the field has grown so much that it is increasingly difficult to follow the diverse range of new discoveries and applications that are appearing. At this point in time, when the field of THz science and technology is moving from an emerging to a more established and interdisciplinary field, it is apt to present a roadmap to help identify the breadth and future directions of the field. The aim of this roadmap is to present a snapshot of the present state of THz science and technology in 2017, and provide an opinion on the challenges and opportunities that the future holds. To be able to achieve this aim, we have invited a group of international experts to write 18 sections that cover most of the key areas of THz science and technology. We hope that The 2017 Roadmap on THz science and technology will prove to be a useful resource by providing a wide ranging introduction to the capabilities of THz radiation for those outside or just entering the field as well as providing perspective and breadth for those who are well established. We also feel that this review should serve as a useful guide for government and funding agencies.

Electrodynamic Dust Shield for Space Applications

NASA Technical Reports Server (NTRS)

Mackey, P. J.; Johansen, M. R.; Olsen, R. C.; Raines, M. G.; Phillips, J. R., III; Pollard, J. R. S.; Calle, C. I.

2016-01-01

The International Space Exploration Coordination Group (ISECG) has chosen dust mitigation technology as a Global Exploration Roadmap (GER) critical technology need in order to reduce life cycle cost and risk, and increase the probability of mission success. NASA has also included Particulate Contamination Prevention and Mitigation as a cross-cutting technology to be developed for contamination prevention, cleaning and protection. This technology has been highlighted due to the detrimental effect of dust on both human and robotic missions. During manned Apollo missions, dust caused issues with both equipment and crew. Contamination of equipment caused many issues including incorrect instrument readings and increased temperatures due to masking of thermal radiators. The astronauts were directly affected by dust that covered space suits, obscured face shields and later propagated to the cabin and into the crew's eyes and lungs. Robotic missions on Mars were affected when solar panels were obscured by dust thereby reducing the effectiveness of the solar panels. The Electrostatics and Surface Physics Lab in Swamp Works at the Kennedy Space Center has been developing an Electrodynamic Dust Shield (EDS) to remove dust from multiple surfaces, including glass shields and thermal radiators. This technology has been tested in lab environments and has evolved over several years. Tests of the technology include reduced gravity flights (one-sixth g) in which Apollo Lunar dust samples were successfully removed from glass shields while under vacuum (10(exp -6) kPa).

Conservation in a cup of water: estimating biodiversity and population abundance from environmental DNA.

PubMed

Lodge, David M; Turner, Cameron R; Jerde, Christopher L; Barnes, Matthew A; Chadderton, Lindsay; Egan, Scott P; Feder, Jeffrey L; Mahon, Andrew R; Pfrender, Michael E

2012-06-01

Three mantras often guide species and ecosystem management: (i) for preventing invasions by harmful species, 'early detection and rapid response'; (ii) for conserving imperilled native species, 'protection of biodiversity hotspots'; and (iii) for assessing biosecurity risk, 'an ounce of prevention equals a pound of cure.' However, these and other management goals are elusive when traditional sampling tools (e.g. netting, traps, electrofishing, visual surveys) have poor detection limits, are too slow or are not feasible. One visionary solution is to use an organism's DNA in the environment (eDNA), rather than the organism itself, as the target of detection. In this issue of Molecular Ecology, Thomsen et al. (2012) provide new evidence demonstrating the feasibility of this approach, showing that eDNA is an accurate indicator of the presence of an impressively diverse set of six aquatic or amphibious taxa including invertebrates, amphibians, a fish and a mammal in a wide range of freshwater habitats. They are also the first to demonstrate that the abundance of eDNA, as measured by qPCR, correlates positively with population abundance estimated with traditional tools. Finally, Thomsen et al. (2012) demonstrate that next-generation sequencing of eDNA can quantify species richness. Overall, Thomsen et al. (2012) provide a revolutionary roadmap for using eDNA for detection of species, estimates of relative abundance and quantification of biodiversity. © 2012 Blackwell Publishing Ltd.

Eurogin 2016 Roadmap: how HPV knowledge is changing screening practice.

PubMed

Wentzensen, Nicolas; Arbyn, Marc; Berkhof, Johannes; Bower, Mark; Canfell, Karen; Einstein, Mark; Farley, Christopher; Monsonego, Joseph; Franceschi, Silvia

2017-05-15

Human papillomaviruses (HPVs) are the necessary cause of most cervical cancers, a large proportion of other anogenital cancers, and a subset of oropharyngeal cancers. The knowledge about HPV has led to development of novel HPV-based prevention strategies with important impact on clinical and public health practice. Two complementary reviews have been prepared following the 2015 Eurogin Conference to evaluate how knowledge about HPV is changing practice in HPV infection and disease control through vaccination and screening. This review focuses on screening for cervical and anal cancers in increasingly vaccinated populations. The introduction of HPV vaccines a decade ago has led to reductions in HPV infections and early cancer precursors in countries with wide vaccination coverage. Despite the high efficacy of HPV vaccines, cervical cancer screening will remain important for many decades. Many healthcare systems are considering switching to primary HPV screening, which has higher sensitivity for cervical precancers and allows extending screening intervals. We describe different approaches to implementing HPV-based screening efforts in different healthcare systems with a focus in high-income countries. While the population prevalence for other anogenital cancers is too low for population-based screening, anal cancer incidence is very high in HIV-infected men who have sex with men, warranting consideration of early detection approaches. We summarize the current evidence on HPV-based prevention of anal cancers and highlight important evidence gaps. © 2016 UICC.

Application of Personalized, Predictive, Preventative, and Participatory (P4) Medicine to Obstructive Sleep Apnea. A Roadmap for Improving Care?

PubMed

Pack, Allan I

2016-09-01

Dr. Leroy Hood promotes a paradigm to advance medical care that he calls P4 medicine. The four Ps are: personalized, predictive, preventative, and participatory. P4 medicine encourages a convergence of systems medicine, the digital revolution, and consumer-driven healthcare. Might P4 medicine be applicable to obstructive sleep apnea (OSA)? OSA should be personalized in that there are different structural and physiological pathways to disease. Obesity is a major risk factor. The link between obesity and OSA is likely to be fat deposits in the tongue compromising the upper airway. Clinical features at presentation also vary between patients. There are three distinct subgroups: (1) patients with a primary complaint of insomnia, (2) relatively asymptomatic patients with a high prevalence of cardiovascular comorbidities, and (3) excessively sleepy patients. Currently, there have been limited efforts to identify subgroups of patients on the basis of measures obtained by polysomnography. Yet, these diagnostic studies likely contain considerable predictive information. Likewise, there has currently been limited application of -omic approaches. Determining the relative role of obesity and OSA for particular consequences is challenging, because they both affect the same molecular pathways. There is evidence that the effects of OSA are modified by the level of obesity. These insights may lead to improvements in predicting outcomes to personalized therapies. The final P-participatory-is ideally suited to OSA, with technology to obtain extensive data remotely from continuous positive airway pressure machines. Providing adherence data directly to patients increases their use of continuous positive airway pressure. Thus, the concept of P4 medicine is very applicable to obstructive sleep apnea and can be the basis for future research efforts.

Technology Development for NASA Mars Missions

NASA Technical Reports Server (NTRS)

Hayati, Samad

2005-01-01

A viewgraph presentation on technology development for NASA Mars Missions is shown. The topics include: 1) Mars mission roadmaps; 2) Focus and Base Technology programs; 3) Technology Infusion; and 4) Feed Forward to Future Missions.

Graphics Processor Units (GPUs)

NASA Technical Reports Server (NTRS)

Wyrwas, Edward J.

2017-01-01

This presentation will include information about Graphics Processor Units (GPUs) technology, NASA Electronic Parts and Packaging (NEPP) tasks, The test setup, test parameter considerations, lessons learned, collaborations, a roadmap, NEPP partners, results to date, and future plans.

Workshop report: Malaria vaccine development in Europe--preparing for the future.

PubMed

Viebig, Nicola K; D'Alessio, Flavia; Draper, Simon J; Sim, B Kim Lee; Mordmüller, Benjamin; Bowyer, Paul W; Luty, Adrian J F; Jungbluth, Stefan; Chitnis, Chetan E; Hill, Adrian V S; Kremsner, Peter; Craig, Alister G; Kocken, Clemens H M; Leroy, Odile

2015-11-17

The deployment of a safe and effective malaria vaccine will be an important tool for the control of malaria and the reduction in malaria deaths. With the launch of the 2030 Malaria Vaccine Technology Roadmap, the malaria community has updated the goals and priorities for the development of such a vaccine and is now paving the way for a second phase of malaria vaccine development. During a workshop in Brussels in November 2014, hosted by the European Vaccine Initiative, key players from the European, North American and African malaria vaccine community discussed European strategies for future malaria vaccine development in the global context. The recommendations of the European malaria community should guide researchers, policy makers and funders of global health research and development in fulfilling the ambitious goals set in the updated Malaria Vaccine Technology Roadmap. Copyright © 2015.

The NASA Astrophysics Data System: Capabilities and Roadmap for the 2020s

NASA Astrophysics Data System (ADS)

Accomazzi, Alberto; ADS Team

2018-06-01

The NASA Astrophysics Data System (ADS) is used daily by researchers and curators as a discovery platform for the Astronomy literature. Over the past several years, the ADS has been adding to the breadth and depth of its contents. Scholarly astronomy articles are now indexed as full-text documents, allowing for complete and accurate literature searches. High-level data products, data links, and software used in refereed astronomy papers are now also being ingested and indexed in our database. All the search functionality exposed in the new ADS interface is also available via its API, which we are continuing to develop and enhance. In this talk I will describe the current system, our current roadmap, and solicit input from the community regarding what additional data, services, and discovery capabilities the ADS should support.

SMART SKINS - A Development Roadmap

NASA Astrophysics Data System (ADS)

Lochocki, Joseph M.

1990-02-01

The Air Force Project Forecast II identified a number of key technology initiatives for development. This paper addresses one such initiative, PT-16, Smart Skins. The concept of the Smart Skin is introduced by briefly highlighting its attributes and potential advantages over standard avionics packaging and maintenance, and then goes on to describe some of the key ingredients necessary for its development. Problem areas are brought out along with some of the required trades that must be made. Finally, a time phased development roadmap is introduced which shows Calspan's proposed sequence of technology development programs that can, in combination, lead to first functional Smart Skins implementations in narrowband form in the late 1990's and in wideband form in first decade of the twenty - first century. A Smart Skins implementation in integral aircraft skin structure form will take at least until 2010.

Towards human exploration of space: the THESEUS review series on neurophysiology research priorities.

PubMed

White, Olivier; Clément, Gilles; Fortrat, Jacques-Olivier; Pavy-LeTraon, Anne; Thonnard, Jean-Louis; Blanc, Stéphane; Wuyts, Floris L; Paloski, William H

2016-01-01

The THESEUS project (Towards Human Exploration of Space: a European Strategy), initiated within the seventh Framework Programme by the European Commission, aimed at providing a cross-cutting, life-science-based roadmap for Europe's strategy towards human exploration of long space missions, and its relevance to applications on Earth. This topic was investigated by experts in the field, in the framework of the THESEUS project whose aim was to develop an integrated life sciences research roadmap regarding human space exploration. In particular, decades of research have shown that altered gravity impairs neurological responses at large, such as perception, sleep, motor control, and cognitive factors. International experts established a list of key issues that should be addressed in that context and provided several recommendations such as a maximal exploitation of currently available resources on Earth and in space.

Crossing the Chasm: Information Technology to Biomedical Informatics

PubMed Central

Fahy, Brenda G.; Balke, C. William; Umberger, Gloria H.; Talbert, Jeffery; Canales, Denise Niles; Steltenkamp, Carol L.; Conigliaro, Joseph

2011-01-01

Accelerating the translation of new scientific discoveries to improve human health and disease management is the overall goal of a series of initiatives integrated in the National Institutes of Health (NIH) “Roadmap for Medical Research.” The Clinical and Translational Research Award (CTSA) program is, arguably, the most visible component of the NIH Roadmap providing resources to institutions to transform their clinical and translational research enterprises along the goals of the Roadmap. The CTSA program emphasizes biomedical informatics as a critical component for the accomplishment of the NIH’s translational objectives. To be optimally effective, emerging biomedical informatics programs must link with the information technology (IT) platforms of the enterprise clinical operations within academic health centers. This report details one academic health center’s transdisciplinary initiative to create an integrated academic discipline of biomedical informatics through the development of its infrastructure for clinical and translational science infrastructure and response to the CTSA mechanism. This approach required a detailed informatics strategy to accomplish these goals. This transdisciplinary initiative was the impetus for creation of a specialized biomedical informatics core, the Center for Biomedical Informatics (CBI). Development of the CBI codified the need to incorporate medical informatics including quality and safety informatics and enterprise clinical information systems within the CBI. This paper describes the steps taken to develop the biomedical informatics infrastructure, its integration with clinical systems at one academic health center, successes achieved, and barriers encountered during these efforts. PMID:21383632

Small Aircraft Transportation System Concept and Technologies

NASA Technical Reports Server (NTRS)

Holmes, Bruce J.; Durham, Michael H.; Tarry, Scott E.

2005-01-01

This paper summarizes both the vision and the early public-private collaborative research for the Small Aircraft Transportation System (SATS). The paper outlines an operational definition of SATS, describes how SATS conceptually differs from current air transportation capabilities, introduces four SATS operating capabilities, and explains the relation between the SATS operating capabilities and the potential for expanded air mobility. The SATS technology roadmap encompasses on-demand, widely distributed, point-to-point air mobility, through hired-pilot modes in the nearer-term, and through self-operated user modes in the farther-term. The nearer-term concept is based on aircraft and airspace technologies being developed to make the use of smaller, more widely distributed community reliever and general aviation airports and their runways more useful in more weather conditions, in commercial hired-pilot service modes. The farther-term vision is based on technical concepts that could be developed to simplify or automate many of the operational functions in the aircraft and the airspace for meeting future public transportation needs, in personally operated modes. NASA technology strategies form a roadmap between the nearer-term concept and the farther-term vision. This paper outlines a roadmap for scalable, on-demand, distributed air mobility technologies for vehicle and airspace systems. The audiences for the paper include General Aviation manufacturers, small aircraft transportation service providers, the flight training industry, airport and transportation authorities at the Federal, state and local levels, and organizations involved in planning for future National Airspace System advancements.

Overview of current capabilities and research and technology developments for planetary protection

NASA Astrophysics Data System (ADS)

Frick, Andreas; Mogul, Rakesh; Stabekis, Pericles; Conley, Catharine A.; Ehrenfreund, Pascale

2014-07-01

The pace of scientific exploration of our solar system provides ever-increasing insights into potentially habitable environments, and associated concerns for their contamination by Earth organisms. Biological and organic-chemical contamination has been extensively considered by the COSPAR Panel on Planetary Protection (PPP) and has resulted in the internationally recognized regulations to which spacefaring nations adhere, and which have been in place for 40 years. The only successful Mars lander missions with system-level “sterilization” were the Viking landers in the 1970s. Since then different cleanliness requirements have been applied to spacecraft based on their destination, mission type, and scientific objectives. The Planetary Protection Subcommittee of the NASA Advisory Council has noted that a strategic Research & Technology Development (R&TD) roadmap would be very beneficial to encourage the timely availability of effective tools and methodologies to implement planetary protection requirements. New research avenues in planetary protection for ambitious future exploration missions can best be served by developing an over-arching program that integrates capability-driven developments with mission-driven implementation efforts. This paper analyzes the current status concerning microbial reduction and cleaning methods, recontamination control and bio-barriers, operational analysis methods, and addresses concepts for human exploration. Crosscutting research and support activities are discussed and a rationale for a Strategic Planetary Protection R&TD Roadmap is outlined. Such a roadmap for planetary protection provides a forum for strategic planning and will help to enable the next phases of solar system exploration.

TCGA Workflow: Analyze cancer genomics and epigenomics data using Bioconductor packages

PubMed Central

Bontempi, Gianluca; Ceccarelli, Michele; Noushmehr, Houtan

2016-01-01

Biotechnological advances in sequencing have led to an explosion of publicly available data via large international consortia such as The Cancer Genome Atlas (TCGA), The Encyclopedia of DNA Elements (ENCODE), and The NIH Roadmap Epigenomics Mapping Consortium (Roadmap). These projects have provided unprecedented opportunities to interrogate the epigenome of cultured cancer cell lines as well as normal and tumor tissues with high genomic resolution. The Bioconductor project offers more than 1,000 open-source software and statistical packages to analyze high-throughput genomic data. However, most packages are designed for specific data types (e.g. expression, epigenetics, genomics) and there is no one comprehensive tool that provides a complete integrative analysis of the resources and data provided by all three public projects. A need to create an integration of these different analyses was recently proposed. In this workflow, we provide a series of biologically focused integrative analyses of different molecular data. We describe how to download, process and prepare TCGA data and by harnessing several key Bioconductor packages, we describe how to extract biologically meaningful genomic and epigenomic data. Using Roadmap and ENCODE data, we provide a work plan to identify biologically relevant functional epigenomic elements associated with cancer. To illustrate our workflow, we analyzed two types of brain tumors: low-grade glioma (LGG) versus high-grade glioma (glioblastoma multiform or GBM). This workflow introduces the following Bioconductor packages: AnnotationHub, ChIPSeeker, ComplexHeatmap, pathview, ELMER, GAIA, MINET, RTCGAToolbox,  TCGAbiolinks. PMID:28232861