Sample records for previous large scale

  1. Large-scale dynamo action precedes turbulence in shearing box simulations of the magnetorotational instability

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bhat, Pallavi; Ebrahimi, Fatima; Blackman, Eric G.

    Here, we study the dynamo generation (exponential growth) of large-scale (planar averaged) fields in unstratified shearing box simulations of the magnetorotational instability (MRI). In contrast to previous studies restricted to horizontal (x–y) averaging, we also demonstrate the presence of large-scale fields when vertical (y–z) averaging is employed instead. By computing space–time planar averaged fields and power spectra, we find large-scale dynamo action in the early MRI growth phase – a previously unidentified feature. Non-axisymmetric linear MRI modes with low horizontal wavenumbers and vertical wavenumbers near that of expected maximal growth, amplify the large-scale fields exponentially before turbulence and high wavenumbermore » fluctuations arise. Thus the large-scale dynamo requires only linear fluctuations but not non-linear turbulence (as defined by mode–mode coupling). Vertical averaging also allows for monitoring the evolution of the large-scale vertical field and we find that a feedback from horizontal low wavenumber MRI modes provides a clue as to why the large-scale vertical field sustains against turbulent diffusion in the non-linear saturation regime. We compute the terms in the mean field equations to identify the individual contributions to large-scale field growth for both types of averaging. The large-scale fields obtained from vertical averaging are found to compare well with global simulations and quasi-linear analytical analysis from a previous study by Ebrahimi & Blackman. We discuss the potential implications of these new results for understanding the large-scale MRI dynamo saturation and turbulence.« less

  2. Large-scale dynamo action precedes turbulence in shearing box simulations of the magnetorotational instability

    DOE PAGES

    Bhat, Pallavi; Ebrahimi, Fatima; Blackman, Eric G.

    2016-07-06

    Here, we study the dynamo generation (exponential growth) of large-scale (planar averaged) fields in unstratified shearing box simulations of the magnetorotational instability (MRI). In contrast to previous studies restricted to horizontal (x–y) averaging, we also demonstrate the presence of large-scale fields when vertical (y–z) averaging is employed instead. By computing space–time planar averaged fields and power spectra, we find large-scale dynamo action in the early MRI growth phase – a previously unidentified feature. Non-axisymmetric linear MRI modes with low horizontal wavenumbers and vertical wavenumbers near that of expected maximal growth, amplify the large-scale fields exponentially before turbulence and high wavenumbermore » fluctuations arise. Thus the large-scale dynamo requires only linear fluctuations but not non-linear turbulence (as defined by mode–mode coupling). Vertical averaging also allows for monitoring the evolution of the large-scale vertical field and we find that a feedback from horizontal low wavenumber MRI modes provides a clue as to why the large-scale vertical field sustains against turbulent diffusion in the non-linear saturation regime. We compute the terms in the mean field equations to identify the individual contributions to large-scale field growth for both types of averaging. The large-scale fields obtained from vertical averaging are found to compare well with global simulations and quasi-linear analytical analysis from a previous study by Ebrahimi & Blackman. We discuss the potential implications of these new results for understanding the large-scale MRI dynamo saturation and turbulence.« less

  3. Large-scale weakly supervised object localization via latent category learning.

    PubMed

    Chong Wang; Kaiqi Huang; Weiqiang Ren; Junge Zhang; Maybank, Steve

    2015-04-01

    Localizing objects in cluttered backgrounds is challenging under large-scale weakly supervised conditions. Due to the cluttered image condition, objects usually have large ambiguity with backgrounds. Besides, there is also a lack of effective algorithm for large-scale weakly supervised localization in cluttered backgrounds. However, backgrounds contain useful latent information, e.g., the sky in the aeroplane class. If this latent information can be learned, object-background ambiguity can be largely reduced and background can be suppressed effectively. In this paper, we propose the latent category learning (LCL) in large-scale cluttered conditions. LCL is an unsupervised learning method which requires only image-level class labels. First, we use the latent semantic analysis with semantic object representation to learn the latent categories, which represent objects, object parts or backgrounds. Second, to determine which category contains the target object, we propose a category selection strategy by evaluating each category's discrimination. Finally, we propose the online LCL for use in large-scale conditions. Evaluation on the challenging PASCAL Visual Object Class (VOC) 2007 and the large-scale imagenet large-scale visual recognition challenge 2013 detection data sets shows that the method can improve the annotation precision by 10% over previous methods. More importantly, we achieve the detection precision which outperforms previous results by a large margin and can be competitive to the supervised deformable part model 5.0 baseline on both data sets.

  4. Satellite-based characterization of climatic conditions before large-scale general flowering events in Peninsular Malaysia

    PubMed Central

    Azmy, Muna Maryam; Hashim, Mazlan; Numata, Shinya; Hosaka, Tetsuro; Noor, Nur Supardi Md.; Fletcher, Christine

    2016-01-01

    General flowering (GF) is a unique phenomenon wherein, at irregular intervals, taxonomically diverse trees in Southeast Asian dipterocarp forests synchronize their reproduction at the community level. Triggers of GF, including drought and low minimum temperatures a few months previously has been limitedly observed across large regional scales due to lack of meteorological stations. Here, we aim to identify the climatic conditions that trigger large-scale GF in Peninsular Malaysia using satellite sensors, Tropical Rainfall Measuring Mission (TRMM) and Moderate Resolution Imaging Spectroradiometer (MODIS), to evaluate the climatic conditions of focal forests. We observed antecedent drought, low temperature and high photosynthetic radiation conditions before large-scale GF events, suggesting that large-scale GF events could be triggered by these factors. In contrast, we found higher-magnitude GF in forests where lower precipitation preceded large-scale GF events. GF magnitude was also negatively influenced by land surface temperature (LST) for a large-scale GF event. Therefore, we suggest that spatial extent of drought may be related to that of GF forests, and that the spatial pattern of LST may be related to that of GF occurrence. With significant new findings and other results that were consistent with previous research we clarified complicated environmental correlates with the GF phenomenon. PMID:27561887

  5. Satellite-based characterization of climatic conditions before large-scale general flowering events in Peninsular Malaysia.

    PubMed

    Azmy, Muna Maryam; Hashim, Mazlan; Numata, Shinya; Hosaka, Tetsuro; Noor, Nur Supardi Md; Fletcher, Christine

    2016-08-26

    General flowering (GF) is a unique phenomenon wherein, at irregular intervals, taxonomically diverse trees in Southeast Asian dipterocarp forests synchronize their reproduction at the community level. Triggers of GF, including drought and low minimum temperatures a few months previously has been limitedly observed across large regional scales due to lack of meteorological stations. Here, we aim to identify the climatic conditions that trigger large-scale GF in Peninsular Malaysia using satellite sensors, Tropical Rainfall Measuring Mission (TRMM) and Moderate Resolution Imaging Spectroradiometer (MODIS), to evaluate the climatic conditions of focal forests. We observed antecedent drought, low temperature and high photosynthetic radiation conditions before large-scale GF events, suggesting that large-scale GF events could be triggered by these factors. In contrast, we found higher-magnitude GF in forests where lower precipitation preceded large-scale GF events. GF magnitude was also negatively influenced by land surface temperature (LST) for a large-scale GF event. Therefore, we suggest that spatial extent of drought may be related to that of GF forests, and that the spatial pattern of LST may be related to that of GF occurrence. With significant new findings and other results that were consistent with previous research we clarified complicated environmental correlates with the GF phenomenon.

  6. Lessons from a Large-Scale Assessment: Results from Conceptual Inventories

    ERIC Educational Resources Information Center

    Thacker, Beth; Dulli, Hani; Pattillo, Dave; West, Keith

    2014-01-01

    We report conceptual inventory results of a large-scale assessment project at a large university. We studied the introduction of materials and instructional methods informed by physics education research (PER) (physics education research-informed materials) into a department where most instruction has previously been traditional and a significant…

  7. Modulation of Small-scale Turbulence Structure by Large-scale Motions in the Absence of Direct Energy Transfer.

    NASA Astrophysics Data System (ADS)

    Brasseur, James G.; Juneja, Anurag

    1996-11-01

    Previous DNS studies indicate that small-scale structure can be directly altered through ``distant'' dynamical interactions by energetic forcing of the large scales. To remove the possibility of stimulating energy transfer between the large- and small-scale motions in these long-range interactions, we here perturb the large scale structure without altering its energy content by suddenly altering only the phases of large-scale Fourier modes. Scale-dependent changes in turbulence structure appear as a non zero difference field between two simulations from identical initial conditions of isotropic decaying turbulence, one perturbed and one unperturbed. We find that the large-scale phase perturbations leave the evolution of the energy spectrum virtually unchanged relative to the unperturbed turbulence. The difference field, on the other hand, is strongly affected by the perturbation. Most importantly, the time scale τ characterizing the change in in turbulence structure at spatial scale r shortly after initiating a change in large-scale structure decreases with decreasing turbulence scale r. Thus, structural information is transferred directly from the large- to the smallest-scale motions in the absence of direct energy transfer---a long-range effect which cannot be explained by a linear mechanism such as rapid distortion theory. * Supported by ARO grant DAAL03-92-G-0117

  8. Large-scale magnetic fields at high Reynolds numbers in magnetohydrodynamic simulations.

    PubMed

    Hotta, H; Rempel, M; Yokoyama, T

    2016-03-25

    The 11-year solar magnetic cycle shows a high degree of coherence in spite of the turbulent nature of the solar convection zone. It has been found in recent high-resolution magnetohydrodynamics simulations that the maintenance of a large-scale coherent magnetic field is difficult with small viscosity and magnetic diffusivity (≲10 (12) square centimenters per second). We reproduced previous findings that indicate a reduction of the energy in the large-scale magnetic field for lower diffusivities and demonstrate the recovery of the global-scale magnetic field using unprecedentedly high resolution. We found an efficient small-scale dynamo that suppresses small-scale flows, which mimics the properties of large diffusivity. As a result, the global-scale magnetic field is maintained even in the regime of small diffusivities-that is, large Reynolds numbers. Copyright © 2016, American Association for the Advancement of Science.

  9. The Role of Reading Comprehension in Large-Scale Subject-Matter Assessments

    ERIC Educational Resources Information Center

    Zhang, Ting

    2013-01-01

    This study was designed with the overall goal of understanding how difficulties in reading comprehension are associated with early adolescents' performance in large-scale assessments in subject domains including science and civic-related social studies. The current study extended previous research by taking a cognition-centered approach based on…

  10. Addendum to Effectiveness of Cognitive Tutor Algebra I at Scale. Working Paper WR-1050-DEIES

    ERIC Educational Resources Information Center

    Pane, John F.; Griffin, Beth Ann; McCaffrey, Daniel F.; Karam, Rita

    2014-01-01

    This addendum to previously published results presents alternative analyses of data from large-scale effectiveness studies of Cognitive Tutor Algebra I in middle schools and high schools. These alternative analyses produce results that are substantively the same as previously reported. We find a significant positive effect of 0.21 standard…

  11. Large-scale anisotropy in stably stratified rotating flows

    DOE PAGES

    Marino, R.; Mininni, P. D.; Rosenberg, D. L.; ...

    2014-08-28

    We present results from direct numerical simulations of the Boussinesq equations in the presence of rotation and/or stratification, both in the vertical direction. The runs are forced isotropically and randomly at small scales and have spatial resolutions of up tomore » $1024^3$ grid points and Reynolds numbers of $$\\approx 1000$$. We first show that solutions with negative energy flux and inverse cascades develop in rotating turbulence, whether or not stratification is present. However, the purely stratified case is characterized instead by an early-time, highly anisotropic transfer to large scales with almost zero net isotropic energy flux. This is consistent with previous studies that observed the development of vertically sheared horizontal winds, although only at substantially later times. However, and unlike previous works, when sufficient scale separation is allowed between the forcing scale and the domain size, the total energy displays a perpendicular (horizontal) spectrum with power law behavior compatible with $$\\sim k_\\perp^{-5/3}$$, including in the absence of rotation. In this latter purely stratified case, such a spectrum is the result of a direct cascade of the energy contained in the large-scale horizontal wind, as is evidenced by a strong positive flux of energy in the parallel direction at all scales including the largest resolved scales.« less

  12. Large-scale Scanning Transmission Electron Microscopy (Nanotomy) of Healthy and Injured Zebrafish Brain.

    PubMed

    Kuipers, Jeroen; Kalicharan, Ruby D; Wolters, Anouk H G; van Ham, Tjakko J; Giepmans, Ben N G

    2016-05-25

    Large-scale 2D electron microscopy (EM), or nanotomy, is the tissue-wide application of nanoscale resolution electron microscopy. Others and we previously applied large scale EM to human skin pancreatic islets, tissue culture and whole zebrafish larvae(1-7). Here we describe a universally applicable method for tissue-scale scanning EM for unbiased detection of sub-cellular and molecular features. Nanotomy was applied to investigate the healthy and a neurodegenerative zebrafish brain. Our method is based on standardized EM sample preparation protocols: Fixation with glutaraldehyde and osmium, followed by epoxy-resin embedding, ultrathin sectioning and mounting of ultrathin-sections on one-hole grids, followed by post staining with uranyl and lead. Large-scale 2D EM mosaic images are acquired using a scanning EM connected to an external large area scan generator using scanning transmission EM (STEM). Large scale EM images are typically ~ 5 - 50 G pixels in size, and best viewed using zoomable HTML files, which can be opened in any web browser, similar to online geographical HTML maps. This method can be applied to (human) tissue, cross sections of whole animals as well as tissue culture(1-5). Here, zebrafish brains were analyzed in a non-invasive neuronal ablation model. We visualize within a single dataset tissue, cellular and subcellular changes which can be quantified in various cell types including neurons and microglia, the brain's macrophages. In addition, nanotomy facilitates the correlation of EM with light microscopy (CLEM)(8) on the same tissue, as large surface areas previously imaged using fluorescent microscopy, can subsequently be subjected to large area EM, resulting in the nano-anatomy (nanotomy) of tissues. In all, nanotomy allows unbiased detection of features at EM level in a tissue-wide quantifiable manner.

  13. Large-scale Scanning Transmission Electron Microscopy (Nanotomy) of Healthy and Injured Zebrafish Brain

    PubMed Central

    Kuipers, Jeroen; Kalicharan, Ruby D.; Wolters, Anouk H. G.

    2016-01-01

    Large-scale 2D electron microscopy (EM), or nanotomy, is the tissue-wide application of nanoscale resolution electron microscopy. Others and we previously applied large scale EM to human skin pancreatic islets, tissue culture and whole zebrafish larvae1-7. Here we describe a universally applicable method for tissue-scale scanning EM for unbiased detection of sub-cellular and molecular features. Nanotomy was applied to investigate the healthy and a neurodegenerative zebrafish brain. Our method is based on standardized EM sample preparation protocols: Fixation with glutaraldehyde and osmium, followed by epoxy-resin embedding, ultrathin sectioning and mounting of ultrathin-sections on one-hole grids, followed by post staining with uranyl and lead. Large-scale 2D EM mosaic images are acquired using a scanning EM connected to an external large area scan generator using scanning transmission EM (STEM). Large scale EM images are typically ~ 5 - 50 G pixels in size, and best viewed using zoomable HTML files, which can be opened in any web browser, similar to online geographical HTML maps. This method can be applied to (human) tissue, cross sections of whole animals as well as tissue culture1-5. Here, zebrafish brains were analyzed in a non-invasive neuronal ablation model. We visualize within a single dataset tissue, cellular and subcellular changes which can be quantified in various cell types including neurons and microglia, the brain's macrophages. In addition, nanotomy facilitates the correlation of EM with light microscopy (CLEM)8 on the same tissue, as large surface areas previously imaged using fluorescent microscopy, can subsequently be subjected to large area EM, resulting in the nano-anatomy (nanotomy) of tissues. In all, nanotomy allows unbiased detection of features at EM level in a tissue-wide quantifiable manner. PMID:27285162

  14. Implementing Large-Scale Instructional Technology in Kenya: Changing Instructional Practice and Developing Accountability in a National Education System

    ERIC Educational Resources Information Center

    Piper, Benjamin; Oyanga, Arbogast; Mejia, Jessica; Pouezevara, Sarah

    2017-01-01

    Previous large-scale education technology interventions have shown only modest impacts on student achievement. Building on results from an earlier randomized controlled trial of three different applications of information and communication technologies (ICTs) on primary education in Kenya, the Tusome Early Grade Reading Activity developed the…

  15. Progressive Mid-latitude Afforestation: Local and Remote Climate Impacts in the Framework of Two Coupled Earth System Models

    NASA Astrophysics Data System (ADS)

    Lague, Marysa

    Vegetation influences the atmosphere in complex and non-linear ways, such that large-scale changes in vegetation cover can drive changes in climate on both local and global scales. Large-scale land surface changes have been shown to introduce excess energy to one hemisphere, causing a shift in atmospheric circulation on a global scale. However, past work has not quantified how the climate response scales with the area of vegetation. Here, we systematically evaluate the response of climate to linearly increasing the area of forest cover over the northern mid-latitudes. We show that the magnitude of afforestation of the northern mid-latitudes determines the climate response in a non-linear fashion, and identify a threshold in vegetation-induced cloud feedbacks - a concept not previously addressed by large-scale vegetation manipulation experiments. Small increases in tree cover drive compensating cloud feedbacks, while latent heat fluxes reach a threshold after sufficiently large increases in tree cover, causing the troposphere to warm and dry, subsequently reducing cloud cover. Increased absorption of solar radiation at the surface is driven by both surface albedo changes and cloud feedbacks. We identify how vegetation-induced changes in cloud cover further feedback on changes in the global energy balance. We also show how atmospheric cross-equatorial energy transport changes as the area of afforestation is incrementally increased (a relationship which has not previously been demonstrated). This work demonstrates that while some climate effects (such as energy transport) of large scale mid-latitude afforestation scale roughly linearly across a wide range of afforestation areas, others (such as the local partitioning of the surface energy budget) are non-linear, and sensitive to the particular magnitude of mid-latitude forcing. Our results highlight the importance of considering both local and remote climate responses to large-scale vegetation change, and explore the scaling relationship between changes in vegetation cover and the resulting climate impacts.

  16. Instantaneous variance scaling of AIRS thermodynamic profiles using a circular area Monte Carlo approach

    NASA Astrophysics Data System (ADS)

    Dorrestijn, Jesse; Kahn, Brian H.; Teixeira, João; Irion, Fredrick W.

    2018-05-01

    Satellite observations are used to obtain vertical profiles of variance scaling of temperature (T) and specific humidity (q) in the atmosphere. A higher spatial resolution nadir retrieval at 13.5 km complements previous Atmospheric Infrared Sounder (AIRS) investigations with 45 km resolution retrievals and enables the derivation of power law scaling exponents to length scales as small as 55 km. We introduce a variable-sized circular-area Monte Carlo methodology to compute exponents instantaneously within the swath of AIRS that yields additional insight into scaling behavior. While this method is approximate and some biases are likely to exist within non-Gaussian portions of the satellite observational swaths of T and q, this method enables the estimation of scale-dependent behavior within instantaneous swaths for individual tropical and extratropical systems of interest. Scaling exponents are shown to fluctuate between β = -1 and -3 at scales ≥ 500 km, while at scales ≤ 500 km they are typically near β ≈ -2, with q slightly lower than T at the smallest scales observed. In the extratropics, the large-scale β is near -3. Within the tropics, however, the large-scale β for T is closer to -1 as small-scale moist convective processes dominate. In the tropics, q exhibits large-scale β between -2 and -3. The values of β are generally consistent with previous works of either time-averaged spatial variance estimates, or aircraft observations that require averaging over numerous flight observational segments. The instantaneous variance scaling methodology is relevant for cloud parameterization development and the assessment of time variability of scaling exponents.

  17. The impact of Lyman-α radiative transfer on large-scale clustering in the Illustris simulation

    NASA Astrophysics Data System (ADS)

    Behrens, C.; Byrohl, C.; Saito, S.; Niemeyer, J. C.

    2018-06-01

    Context. Lyman-α emitters (LAEs) are a promising probe of the large-scale structure at high redshift, z ≳ 2. In particular, the Hobby-Eberly Telescope Dark Energy Experiment aims at observing LAEs at 1.9 < z < 3.5 to measure the baryon acoustic oscillation (BAO) scale and the redshift-space distortion (RSD). However, it has been pointed out that the complicated radiative transfer (RT) of the resonant Lyman-α emission line generates an anisotropic selection bias in the LAE clustering on large scales, s ≳ 10 Mpc. This effect could potentially induce a systematic error in the BAO and RSD measurements. Also, there exists a recent claim to have observational evidence of the effect in the Lyman-α intensity map, albeit statistically insignificant. Aims: We aim at quantifying the impact of the Lyman-α RT on the large-scale galaxy clustering in detail. For this purpose, we study the correlations between the large-scale environment and the ratio of an apparent Lyman-α luminosity to an intrinsic one, which we call the "observed fraction", at 2 < z < 6. Methods: We apply our Lyman-α RT code by post-processing the full Illustris simulations. We simply assume that the intrinsic luminosity of the Lyman-α emission is proportional to the star formation rate of galaxies in Illustris, yielding a sufficiently large sample of LAEs to measure the anisotropic selection bias. Results: We find little correlation between large-scale environment and the observed fraction induced by the RT, and hence a smaller anisotropic selection bias than has previously been claimed. We argue that the anisotropy was overestimated in previous work due to insufficient spatial resolution; it is important to keep the resolution such that it resolves the high-density region down to the scale of the interstellar medium, that is, 1 physical kpc. We also find that the correlation can be further enhanced by assumptions in modeling intrinsic Lyman-α emission.

  18. Spatially resolved Spectroscopy of Europa’s Large-scale Compositional Units at 3-4 μm with Keck NIRSPEC

    NASA Astrophysics Data System (ADS)

    Fischer, P. D.; Brown, M. E.; Trumbo, S. K.; Hand, K. P.

    2017-01-01

    We present spatially resolved spectroscopic observations of Europa’s surface at 3-4 μm obtained with the near-infrared spectrograph and adaptive optics system on the Keck II telescope. These are the highest quality spatially resolved reflectance spectra of Europa’s surface at 3-4 μm. The observations spatially resolve Europa’s large-scale compositional units at a resolution of several hundred kilometers. The spectra show distinct features and geographic variations associated with known compositional units; in particular, large-scale leading hemisphere chaos shows a characteristic longward shift in peak reflectance near 3.7 μm compared to icy regions. These observations complement previous spectra of large-scale chaos, and can aid efforts to identify the endogenous non-ice species.

  19. Detection of large-scale concentric gravity waves from a Chinese airglow imager network

    NASA Astrophysics Data System (ADS)

    Lai, Chang; Yue, Jia; Xu, Jiyao; Yuan, Wei; Li, Qinzeng; Liu, Xiao

    2018-06-01

    Concentric gravity waves (CGWs) contain a broad spectrum of horizontal wavelengths and periods due to their instantaneous localized sources (e.g., deep convection, volcanic eruptions, or earthquake, etc.). However, it is difficult to observe large-scale gravity waves of >100 km wavelength from the ground for the limited field of view of a single camera and local bad weather. Previously, complete large-scale CGW imagery could only be captured by satellite observations. In the present study, we developed a novel method that uses assembling separate images and applying low-pass filtering to obtain temporal and spatial information about complete large-scale CGWs from a network of all-sky airglow imagers. Coordinated observations from five all-sky airglow imagers in Northern China were assembled and processed to study large-scale CGWs over a wide area (1800 km × 1 400 km), focusing on the same two CGW events as Xu et al. (2015). Our algorithms yielded images of large-scale CGWs by filtering out the small-scale CGWs. The wavelengths, wave speeds, and periods of CGWs were measured from a sequence of consecutive assembled images. Overall, the assembling and low-pass filtering algorithms can expand the airglow imager network to its full capacity regarding the detection of large-scale gravity waves.

  20. Personality in 100,000 Words: A large-scale analysis of personality and word use among bloggers

    PubMed Central

    Yarkoni, Tal

    2010-01-01

    Previous studies have found systematic associations between personality and individual differences in word use. Such studies have typically focused on broad associations between major personality domains and aggregate word categories, potentially masking more specific associations. Here I report the results of a large-scale analysis of personality and word use in a large sample of blogs (N=694). The size of the dataset enabled pervasive correlations with personality to be identified for a broad range of lexical variables, including both aggregate word categories and individual English words. The results replicated category-level findings from previous offline studies, identified numerous novel associations at both a categorical and single-word level, and underscored the value of complementary approaches to the study of personality and word use. PMID:20563301

  1. Breed locally, disperse globally: Fine-scale genetic structure despite landscape-scale panmixia in a fire-specialist

    Treesearch

    Jennifer C. Pierson; Fred W. Allendorf; Pierre Drapeau; Michael K. Schwartz

    2013-01-01

    An exciting advance in the understanding of metapopulation dynamics has been the investigation of how populations respond to ephemeral patches that go 'extinct' during the lifetime of an individual. Previous research has shown that this scenario leads to genetic homogenization across large spatial scales. However, little is known about fine-scale genetic...

  2. Turbulent pipe flow at extreme Reynolds numbers.

    PubMed

    Hultmark, M; Vallikivi, M; Bailey, S C C; Smits, A J

    2012-03-02

    Both the inherent intractability and complex beauty of turbulence reside in its large range of physical and temporal scales. This range of scales is captured by the Reynolds number, which in nature and in many engineering applications can be as large as 10(5)-10(6). Here, we report turbulence measurements over an unprecedented range of Reynolds numbers using a unique combination of a high-pressure air facility and a new nanoscale anemometry probe. The results reveal previously unknown universal scaling behavior for the turbulent velocity fluctuations, which is remarkably similar to the well-known scaling behavior of the mean velocity distribution.

  3. On the large scale structure of X-ray background sources

    NASA Technical Reports Server (NTRS)

    Bi, H. G.; Meszaros, A.; Meszaros, P.

    1991-01-01

    The large scale clustering of the sources responsible for the X-ray background is discussed, under the assumption of a discrete origin. The formalism necessary for calculating the X-ray spatial fluctuations in the most general case where the source density contrast in structures varies with redshift is developed. A comparison of this with observational limits is useful for obtaining information concerning various galaxy formation scenarios. The calculations presented show that a varying density contrast has a small impact on the expected X-ray fluctuations. This strengthens and extends previous conclusions concerning the size and comoving density of large scale structures at redshifts 0.5 between 4.0.

  4. Shear strength of clay and silt embankments.

    DOT National Transportation Integrated Search

    2009-09-01

    Highway embankment is one of the most common large-scale geotechnical facilities constructed in Ohio. In the past, the design of these embankments was largely based on soil shear strength properties that had been estimated from previously published e...

  5. Relationships between large-scale circulation patterns and carbon dioxide exchange by a deciduous forest

    NASA Astrophysics Data System (ADS)

    Zhang, Jingyong; Wu, Lingyun; Huang, Gang; Notaro, Michael

    2011-02-01

    In this study, we focus on a deciduous forest in central Massachusetts and investigate the relationships between global climate indices and CO2 exchange using eddy-covariance flux measurements from 1992 to 2007. Results suggest that large-scale circulation patterns influence the annual CO2 exchange in the forest through their effects on the local surface climate. Annual gross ecosystem exchange (GEE) in the forest is closely associated with spring El Niño-Southern Oscillation (ENSO) and Pacific Decadal Oscillation (PDO), previous fall Atlantic Multidecadal Oscillation (AMO), and previous winter East Pacific-North Pacific (EP-NP) pattern. Annual net ecosystem exchange (NEE) responds to previous fall AMO and PDO, while annual respiration (R) is impacted by previous fall ENSO and Pacific/North American Oscillation (PNA). Regressions based on these relationships are developed to simulate the annual GEE, NEE, and R. To avoid problems of multicollinearity, we compute a "Composite Index for GEE (CIGEE)" based on a linear combination of spring ENSO and PDO, fall AMO, and winter EP-NP and a "Composite Index for R (CIR)" based on a linear combination of fall ENSO and PNA. CIGEE, CIR, and fall AMO and PDO can explain 41, 27, and 40% of the variance of the annual GEE, R, and NEE, respectively. We further apply the methodology to two other northern midlatitude forests and find that interannual variabilities in NEE of the two forests are largely controlled by large-scale circulation patterns. This study suggests that global climate indices provide the potential for predicting CO2 exchange variability in the northern midlatitude forests.

  6. Large-scale dynamos in rapidly rotating plane layer convection

    NASA Astrophysics Data System (ADS)

    Bushby, P. J.; Käpylä, P. J.; Masada, Y.; Brandenburg, A.; Favier, B.; Guervilly, C.; Käpylä, M. J.

    2018-05-01

    Context. Convectively driven flows play a crucial role in the dynamo processes that are responsible for producing magnetic activity in stars and planets. It is still not fully understood why many astrophysical magnetic fields have a significant large-scale component. Aims: Our aim is to investigate the dynamo properties of compressible convection in a rapidly rotating Cartesian domain, focusing upon a parameter regime in which the underlying hydrodynamic flow is known to be unstable to a large-scale vortex instability. Methods: The governing equations of three-dimensional non-linear magnetohydrodynamics (MHD) are solved numerically. Different numerical schemes are compared and we propose a possible benchmark case for other similar codes. Results: In keeping with previous related studies, we find that convection in this parameter regime can drive a large-scale dynamo. The components of the mean horizontal magnetic field oscillate, leading to a continuous overall rotation of the mean field. Whilst the large-scale vortex instability dominates the early evolution of the system, the large-scale vortex is suppressed by the magnetic field and makes a negligible contribution to the mean electromotive force that is responsible for driving the large-scale dynamo. The cycle period of the dynamo is comparable to the ohmic decay time, with longer cycles for dynamos in convective systems that are closer to onset. In these particular simulations, large-scale dynamo action is found only when vertical magnetic field boundary conditions are adopted at the upper and lower boundaries. Strongly modulated large-scale dynamos are found at higher Rayleigh numbers, with periods of reduced activity (grand minima-like events) occurring during transient phases in which the large-scale vortex temporarily re-establishes itself, before being suppressed again by the magnetic field.

  7. A global probabilistic tsunami hazard assessment from earthquake sources

    USGS Publications Warehouse

    Davies, Gareth; Griffin, Jonathan; Lovholt, Finn; Glimsdal, Sylfest; Harbitz, Carl; Thio, Hong Kie; Lorito, Stefano; Basili, Roberto; Selva, Jacopo; Geist, Eric L.; Baptista, Maria Ana

    2017-01-01

    Large tsunamis occur infrequently but have the capacity to cause enormous numbers of casualties, damage to the built environment and critical infrastructure, and economic losses. A sound understanding of tsunami hazard is required to underpin management of these risks, and while tsunami hazard assessments are typically conducted at regional or local scales, globally consistent assessments are required to support international disaster risk reduction efforts, and can serve as a reference for local and regional studies. This study presents a global-scale probabilistic tsunami hazard assessment (PTHA), extending previous global-scale assessments based largely on scenario analysis. Only earthquake sources are considered, as they represent about 80% of the recorded damaging tsunami events. Globally extensive estimates of tsunami run-up height are derived at various exceedance rates, and the associated uncertainties are quantified. Epistemic uncertainties in the exceedance rates of large earthquakes often lead to large uncertainties in tsunami run-up. Deviations between modelled tsunami run-up and event observations are quantified, and found to be larger than suggested in previous studies. Accounting for these deviations in PTHA is important, as it leads to a pronounced increase in predicted tsunami run-up for a given exceedance rate.

  8. Large-Scale Coronal Heating from the Solar Magnetic Network

    NASA Technical Reports Server (NTRS)

    Falconer, David A.; Moore, Ronald L.; Porter, Jason G.; Hathaway, David H.

    1999-01-01

    In Fe 12 images from SOHO/EIT, the quiet solar corona shows structure on scales ranging from sub-supergranular (i.e., bright points and coronal network) to multi- supergranular. In Falconer et al 1998 (Ap.J., 501, 386) we suppressed the large-scale background and found that the network-scale features are predominantly rooted in the magnetic network lanes at the boundaries of the supergranules. The emission of the coronal network and bright points contribute only about 5% of the entire quiet solar coronal Fe MI emission. Here we investigate the large-scale corona, the supergranular and larger-scale structure that we had previously treated as a background, and that emits 95% of the total Fe XII emission. We compare the dim and bright halves of the large- scale corona and find that the bright half is 1.5 times brighter than the dim half, has an order of magnitude greater area of bright point coverage, has three times brighter coronal network, and has about 1.5 times more magnetic flux than the dim half These results suggest that the brightness of the large-scale corona is more closely related to the large- scale total magnetic flux than to bright point activity. We conclude that in the quiet sun: (1) Magnetic flux is modulated (concentrated/diluted) on size scales larger than supergranules. (2) The large-scale enhanced magnetic flux gives an enhanced, more active, magnetic network and an increased incidence of network bright point formation. (3) The heating of the large-scale corona is dominated by more widespread, but weaker, network activity than that which heats the bright points. This work was funded by the Solar Physics Branch of NASA's office of Space Science through the SR&T Program and the SEC Guest Investigator Program.

  9. Commentary: The Observed Association between Autistic Severity Measured by the Social Responsiveness Scale (SRS) and General Psychopathology-- A Response to Hus et al.()

    ERIC Educational Resources Information Center

    Constantino, John N.; Frazier, Thomas W.

    2013-01-01

    In their analysis of the accumulated data from the clinically ascertained Simons Simplex Collection (SSC), Hus et al. (2013) provide a large-scale clinical replication of previously reported associations (see Constantino, Hudziak & Todd, 2003) between quantitative autistic traits [as measured by the Social Responsiveness Scale (SRS)] and…

  10. Centrifuge impact cratering experiments: Scaling laws for non-porous targets

    NASA Technical Reports Server (NTRS)

    Schmidt, Robert M.

    1987-01-01

    A geotechnical centrifuge was used to investigate large body impacts onto planetary surfaces. At elevated gravity, it is possible to match various dimensionless similarity parameters which were shown to govern large scale impacts. Observations of crater growth and target flow fields have provided detailed and critical tests of a complete and unified scaling theory for impact cratering. Scaling estimates were determined for nonporous targets. Scaling estimates for large scale cratering in rock proposed previously by others have assumed that the crater radius is proportional to powers of the impactor energy and gravity, with no additional dependence on impact velocity. The size scaling laws determined from ongoing centrifuge experiments differ from earlier ones in three respects. First, a distinct dependence of impact velocity is recognized, even for constant impactor energy. Second, the present energy exponent for low porosity targets, like competent rock, is lower than earlier estimates. Third, the gravity exponent is recognized here as being related to both the energy and the velocity exponents.

  11. Evidence of fuels management and fire weather influencing fire severity in an extreme fire event

    USGS Publications Warehouse

    Lydersen, Jamie M; Collins, Brandon M.; Brooks, Matthew L.; Matchett, John R.; Shive, Kristen L.; Povak, Nicholas A.; Kane, Van R.; Smith, Douglas F.

    2017-01-01

    Following changes in vegetation structure and pattern, along with a changing climate, large wildfire incidence has increased in forests throughout the western U.S. Given this increase there is great interest in whether fuels treatments and previous wildfire can alter fire severity patterns in large wildfires. We assessed the relative influence of previous fuels treatments (including wildfire), fire weather, vegetation and water balance on fire severity in the Rim Fire of 2013. We did this at three different spatial scales to investigate whether the influences on fire severity changed across scales. Both fuels treatments and previous low to moderate severity wildfire reduced the prevalence of high severity fire. In general, areas without recent fuels treatments and areas that previously burned at high severity tended to have a greater proportion of high severity fire in the Rim Fire. Areas treated with prescribed fire, especially when combined with thinning, had the lowest proportions of high severity. Proportion of the landscape burned at high severity was most strongly influenced by fire weather and proportional area previously treated for fuels or burned by low to moderate severity wildfire. The proportion treated needed to effectively reduce the amount of high fire severity fire varied by spatial scale of analysis, with smaller spatial scales requiring a greater proportion treated to see an effect on fire severity. When moderate and high severity fire encountered a previously treated area, fire severity was significantly reduced in the treated area relative to the adjacent untreated area. Our results show that fuels treatments and low to moderate severity wildfire can reduce fire severity in a subsequent wildfire, even when burning under fire growth conditions. These results serve as further evidence that both fuels treatments and lower severity wildfire can increase forest resilience.

  12. Mean-field dynamo in a turbulence with shear and kinetic helicity fluctuations.

    PubMed

    Kleeorin, Nathan; Rogachevskii, Igor

    2008-03-01

    We study the effects of kinetic helicity fluctuations in a turbulence with large-scale shear using two different approaches: the spectral tau approximation and the second-order correlation approximation (or first-order smoothing approximation). These two approaches demonstrate that homogeneous kinetic helicity fluctuations alone with zero mean value in a sheared homogeneous turbulence cannot cause a large-scale dynamo. A mean-field dynamo is possible when the kinetic helicity fluctuations are inhomogeneous, which causes a nonzero mean alpha effect in a sheared turbulence. On the other hand, the shear-current effect can generate a large-scale magnetic field even in a homogeneous nonhelical turbulence with large-scale shear. This effect was investigated previously for large hydrodynamic and magnetic Reynolds numbers. In this study we examine the threshold required for the shear-current dynamo versus Reynolds number. We demonstrate that there is no need for a developed inertial range in order to maintain the shear-current dynamo (e.g., the threshold in the Reynolds number is of the order of 1).

  13. Fine-scale characteristics of interplanetary sector

    NASA Technical Reports Server (NTRS)

    Behannon, K. W.; Neubauer, F. M.; Barnstoff, H.

    1980-01-01

    The structure of the interplanetary sector boundaries observed by Helios 1 within sector transition regions was studied. Such regions consist of intermediate (nonspiral) average field orientations in some cases, as well as a number of large angle directional discontinuities (DD's) on the fine scale (time scales 1 hour). Such DD's are found to be more similar to tangential than rotational discontinuities, to be oriented on average more nearly perpendicular than parallel to the ecliptic plane to be accompanied usually by a large dip ( 80%) in B and, with a most probable thickness of 3 x 10 to the 4th power km, significantly thicker previously studied. It is hypothesized that the observed structures represent multiple traversals of the global heliospheric current sheet due to local fluctuations in the position of the sheet. There is evidence that such fluctuations are sometimes produced by wavelike motions or surface corrugations of scale length 0.05 - 0.1 AU superimposed on the large scale structure.

  14. Outcomes and Process in Reading Tutoring

    ERIC Educational Resources Information Center

    Topping, K. J.; Thurston, A.; McGavock, K.; Conlin, N.

    2012-01-01

    Background: Large-scale randomised controlled trials are relatively rare in education. The present study approximates to, but is not exactly, a randomised controlled trial. It was an attempt to scale up previous small peer tutoring projects, while investing only modestly in continuing professional development for teachers. Purpose: A two-year…

  15. Sparse maps—A systematic infrastructure for reduced-scaling electronic structure methods. II. Linear scaling domain based pair natural orbital coupled cluster theory

    NASA Astrophysics Data System (ADS)

    Riplinger, Christoph; Pinski, Peter; Becker, Ute; Valeev, Edward F.; Neese, Frank

    2016-01-01

    Domain based local pair natural orbital coupled cluster theory with single-, double-, and perturbative triple excitations (DLPNO-CCSD(T)) is a highly efficient local correlation method. It is known to be accurate and robust and can be used in a black box fashion in order to obtain coupled cluster quality total energies for large molecules with several hundred atoms. While previous implementations showed near linear scaling up to a few hundred atoms, several nonlinear scaling steps limited the applicability of the method for very large systems. In this work, these limitations are overcome and a linear scaling DLPNO-CCSD(T) method for closed shell systems is reported. The new implementation is based on the concept of sparse maps that was introduced in Part I of this series [P. Pinski, C. Riplinger, E. F. Valeev, and F. Neese, J. Chem. Phys. 143, 034108 (2015)]. Using the sparse map infrastructure, all essential computational steps (integral transformation and storage, initial guess, pair natural orbital construction, amplitude iterations, triples correction) are achieved in a linear scaling fashion. In addition, a number of additional algorithmic improvements are reported that lead to significant speedups of the method. The new, linear-scaling DLPNO-CCSD(T) implementation typically is 7 times faster than the previous implementation and consumes 4 times less disk space for large three-dimensional systems. For linear systems, the performance gains and memory savings are substantially larger. Calculations with more than 20 000 basis functions and 1000 atoms are reported in this work. In all cases, the time required for the coupled cluster step is comparable to or lower than for the preceding Hartree-Fock calculation, even if this is carried out with the efficient resolution-of-the-identity and chain-of-spheres approximations. The new implementation even reduces the error in absolute correlation energies by about a factor of two, compared to the already accurate previous implementation.

  16. Shifts in Summertime Precipitation Accumulation Distributions over the US

    NASA Astrophysics Data System (ADS)

    Martinez-Villalobos, C.; Neelin, J. D.

    2016-12-01

    Precipitation accumulations, i.e., the amount of precipitation integrated over the course of an event, is a variable with both important physical and societal implications. Previous observational studies show that accumulation distributions have a characteristic shape, with an approximately power law decrease at first, followed by a sharp decrease at a characteristic large event cutoff scale. This cutoff scale is important as it limits the biggest accumulation events. Stochastic prototypes show that the resulting distributions, and importantly the large event cutoff scale, can be understood as a result of the interplay between moisture loss by precipitation and changes in moisture sinks/sources due to fluctuations in moisture divergence over the course of a precipitation event. The strength of this fluctuating moisture sink/source term is expected to increase under global warming, with both theory and climate model simulations predicting a concomitant increase in the large event cutoff scale. This cutoff scale increase has important consequences as it implies an approximately exponential increase for the largest accumulation events. Given its importance, in this study we characterize and track changes in the distribution of precipitation events accumulations over the contiguous US. Accumulation distributions are calculated using hourly precipitation data from 1700 stations, covering the 1974-2013 period over May-October. The resulting distributions largely follow the aforementioned shape, with individual cutoff scales depending on the local climate. An increase in the large event cutoff scale over this period is observed over several regions over the US, most notably over the eastern third of the US. In agreement with the increase in the cutoff, almost exponential increases in the highest accumulation percentiles occur over these regions, with increases in the 99.9 percentile in the Northeast of 70% for example. The relationship to changes in daily precipitation that have previously been noted and to changes in the moisture budget over this period are examined.

  17. Shifts in Summertime Precipitation Accumulation Distributions over the US

    NASA Astrophysics Data System (ADS)

    Martinez-Villalobos, C.; Neelin, J. D.

    2017-12-01

    Precipitation accumulations, i.e., the amount of precipitation integrated over the course of an event, is a variable with both important physical and societal implications. Previous observational studies show that accumulation distributions have a characteristic shape, with an approximately power law decrease at first, followed by a sharp decrease at a characteristic large event cutoff scale. This cutoff scale is important as it limits the biggest accumulation events. Stochastic prototypes show that the resulting distributions, and importantly the large event cutoff scale, can be understood as a result of the interplay between moisture loss by precipitation and changes in moisture sinks/sources due to fluctuations in moisture divergence over the course of a precipitation event. The strength of this fluctuating moisture sink/source term is expected to increase under global warming, with both theory and climate model simulations predicting a concomitant increase in the large event cutoff scale. This cutoff scale increase has important consequences as it implies an approximately exponential increase for the largest accumulation events. Given its importance, in this study we characterize and track changes in the distribution of precipitation events accumulations over the contiguous US. Accumulation distributions are calculated using hourly precipitation data from 1700 stations, covering the 1974-2013 period over May-October. The resulting distributions largely follow the aforementioned shape, with individual cutoff scales depending on the local climate. An increase in the large event cutoff scale over this period is observed over several regions over the US, most notably over the eastern third of the US. In agreement with the increase in the cutoff, almost exponential increases in the highest accumulation percentiles occur over these regions, with increases in the 99.9 percentile in the Northeast of 70% for example. The relationship to changes in daily precipitation that have previously been noted and to changes in the moisture budget over this period are examined.

  18. The D-material universe

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Elghozi, Thomas; Mavromatos, Nick E.; Sakellariadou, Mairi

    In a previous publication by some of the authors (N.E.M., M.S. and M.F.Y.), we have argued that the ''D-material universe'', that is a model of a brane world propagating in a higher-dimensional bulk populated by collections of D-particle stringy defects, provides a model for the growth of large-scale structure in the universe via the vector field in its spectrum. The latter corresponds to D-particle recoil velocity excitations as a result of the interactions of the defects with stringy matter and radiation on the brane world. In this article, we first elaborate further on the results of the previous study onmore » the galactic growth era and analyse the circumstances under which the D-particle recoil velocity fluid may ''mimic'' dark matter in galaxies. A lensing phenomenology is also presented for some samples of galaxies, which previously were known to provide tension for modified gravity (TeVeS) models. The current model is found in agreement with these lensing data. Then we discuss a cosmic evolution for the D-material universe by analysing the conditions under which the late eras of this universe associated with large-scale structure are connected to early epochs, where inflation takes place. It is shown that inflation is induced by dense populations of D-particles in the early universe, with the rôle of the inflaton field played by the condensate of the D-particle recoil-velocity fields under their interaction with relativistic stringy matter, only for sufficiently large brane tensions and low string mass scales compared to the Hubble scale. On the other hand, for large string scales, where the recoil-velocity condensate fields are weak, inflation cannot be driven by the D-particle defects alone. In such cases inflation may be driven by dilaton (or other moduli) fields in the underlying string theory.« less

  19. Functional Independent Scaling Relation for ORR/OER Catalysts

    DOE PAGES

    Christensen, Rune; Hansen, Heine A.; Dickens, Colin F.; ...

    2016-10-11

    A widely used adsorption energy scaling relation between OH* and OOH* intermediates in the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER), has previously been determined using density functional theory and shown to dictate a minimum thermodynamic overpotential for both reactions. Here, we show that the oxygen–oxygen bond in the OOH* intermediate is, however, not well described with the previously used class of exchange-correlation functionals. By quantifying and correcting the systematic error, an improved description of gaseous peroxide species versus experimental data and a reduction in calculational uncertainty is obtained. For adsorbates, we find that the systematic error largelymore » cancels the vdW interaction missing in the original determination of the scaling relation. An improved scaling relation, which is fully independent of the applied exchange–correlation functional, is obtained and found to differ by 0.1 eV from the original. Lastly, this largely confirms that, although obtained with a method suffering from systematic errors, the previously obtained scaling relation is applicable for predictions of catalytic activity.« less

  20. Non-linear scale interactions in a forced turbulent boundary layer

    NASA Astrophysics Data System (ADS)

    Duvvuri, Subrahmanyam; McKeon, Beverley

    2015-11-01

    A strong phase-organizing influence exerted by a single synthetic large-scale spatio-temporal mode on directly-coupled (through triadic interactions) small scales in a turbulent boundary layer forced by a spatially-impulsive dynamic wall-roughness patch was previously demonstrated by the authors (J. Fluid Mech. 2015, vol. 767, R4). The experimental set-up was later enhanced to allow for simultaneous forcing of multiple scales in the flow. Results and analysis are presented from a new set of novel experiments where two distinct large scales are forced in the flow by a dynamic wall-roughness patch. The internal non-linear forcing of two other scales with triadic consistency to the artificially forced large scales, corresponding to sum and difference in wavenumbers, is dominated by the latter. This allows for a forcing-response (input-output) type analysis of the two triadic scales, and naturally lends itself to a resolvent operator based model (e.g. McKeon & Sharma, J. Fluid Mech. 2010, vol. 658, pp. 336-382) of the governing Navier-Stokes equations. The support of AFOSR (grant #FA 9550-12-1-0469, program manager D. Smith) is gratefully acknowledged.

  1. Learned perceptual associations influence visuomotor programming under limited conditions: kinematic consistency.

    PubMed

    Haffenden, Angela M; Goodale, Melvyn A

    2002-12-01

    Previous findings have suggested that visuomotor programming can make use of learned size information in experimental paradigms where movement kinematics are quite consistent from trial to trial. The present experiment was designed to test whether or not this conclusion could be generalized to a different manipulation of kinematic variability. As in previous work, an association was established between the size and colour of square blocks (e.g. red = large; yellow = small, or vice versa). Associating size and colour in this fashion has been shown to reliably alter the perceived size of two test blocks halfway in size between the large and small blocks: estimations of the test block matched in colour to the group of large blocks are smaller than estimations of the test block matched to the group of small blocks. Subjects grasped the blocks, and on other trials estimated the size of the blocks. These changes in perceived block size were incorporated into grip scaling only when movement kinematics were highly consistent from trial to trial; that is, when the blocks were presented in the same location on each trial. When the blocks were presented in different locations grip scaling remained true to the metrics of the test blocks despite the changes in perceptual estimates of block size. These results support previous findings suggesting that kinematic consistency facilitates the incorporation of learned perceptual information into grip scaling.

  2. SPATIALLY RESOLVED SPECTROSCOPY OF EUROPA’S LARGE-SCALE COMPOSITIONAL UNITS AT 3–4 μ m WITH KECK NIRSPEC

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fischer, P. D.; Brown, M. E.; Trumbo, S. K.

    2017-01-01

    We present spatially resolved spectroscopic observations of Europa’s surface at 3–4 μ m obtained with the near-infrared spectrograph and adaptive optics system on the Keck II telescope. These are the highest quality spatially resolved reflectance spectra of Europa’s surface at 3–4 μ m. The observations spatially resolve Europa’s large-scale compositional units at a resolution of several hundred kilometers. The spectra show distinct features and geographic variations associated with known compositional units; in particular, large-scale leading hemisphere chaos shows a characteristic longward shift in peak reflectance near 3.7 μ m compared to icy regions. These observations complement previous spectra of large-scalemore » chaos, and can aid efforts to identify the endogenous non-ice species.« less

  3. The mean density and two-point correlation function for the CfA redshift survey slices

    NASA Technical Reports Server (NTRS)

    De Lapparent, Valerie; Geller, Margaret J.; Huchra, John P.

    1988-01-01

    The effect of large-scale inhomogeneities on the determination of the mean number density and the two-point spatial correlation function were investigated for two complete slices of the extension of the Center for Astrophysics (CfA) redshift survey (de Lapparent et al., 1986). It was found that the mean galaxy number density for the two strips is uncertain by 25 percent, more so than previously estimated. The large uncertainty in the mean density introduces substantial uncertainty in the determination of the two-point correlation function, particularly at large scale; thus, for the 12-deg slice of the CfA redshift survey, the amplitude of the correlation function at intermediate scales is uncertain by a factor of 2. The large uncertainties in the correlation functions might reflect the lack of a fair sample.

  4. Contribution of large scale coherence to wind turbine power: A large eddy simulation study in periodic wind farms

    NASA Astrophysics Data System (ADS)

    Chatterjee, Tanmoy; Peet, Yulia T.

    2018-03-01

    Length scales of eddies involved in the power generation of infinite wind farms are studied by analyzing the spectra of the turbulent flux of mean kinetic energy (MKE) from large eddy simulations (LES). Large-scale structures with an order of magnitude bigger than the turbine rotor diameter (D ) are shown to have substantial contribution to wind power. Varying dynamics in the intermediate scales (D -10 D ) are also observed from a parametric study involving interturbine distances and hub height of the turbines. Further insight about the eddies responsible for the power generation have been provided from the scaling analysis of two-dimensional premultiplied spectra of MKE flux. The LES code is developed in a high Reynolds number near-wall modeling framework, using an open-source spectral element code Nek5000, and the wind turbines have been modelled using a state-of-the-art actuator line model. The LES of infinite wind farms have been validated against the statistical results from the previous literature. The study is expected to improve our understanding of the complex multiscale dynamics in the domain of large wind farms and identify the length scales that contribute to the power. This information can be useful for design of wind farm layout and turbine placement that take advantage of the large-scale structures contributing to wind turbine power.

  5. Outcomes in a Randomised Controlled Trial of Mathematics Tutoring

    ERIC Educational Resources Information Center

    Topping, K. J.; Miller, D.; Murray, P.; Henderson, S.; Fortuna, C.; Conlin, N.

    2011-01-01

    Background: Large-scale randomised controlled trials (RCT) are relatively rare in education. The present study was an attempt to scale up previous small peer tutoring projects, while investing only modestly in continuing professional development for teachers. Purpose: A two-year RCT of peer tutoring in mathematics was undertaken in one local…

  6. Landscape-scale carbon sampling strategy-lessons learned. Chapter 17

    Treesearch

    John B. Bradford; Peter Weishampel; Marie-Louise Smith; Randall Kolka; David Y. Hollinger; Richard A. Birdsey; Scott Ollinger; Michael Ryan

    2008-01-01

    Previous chapters examined individual processes relevant to forest carbon cycling, and characterized measurement approaches for understanding those processes at landscape scales. In this final chapter, we address our overall approach to understanding forest carbon dynamics over large areas. Our objective is to identify any lessons that we learned in the course of...

  7. Scale-Up of Safe & Civil Schools' Model for School-Wide Positive Behavioral Interventions and Supports

    ERIC Educational Resources Information Center

    Smolkowski, Keith; Strycker, Lisa; Ward, Bryce

    2016-01-01

    This study evaluated the scale-up of a Safe & Civil Schools "Foundations: Establishing Positive Discipline Policies" positive behavioral interventions and supports initiative through 4 years of "real-world" implementation in a large urban school district. The study extends results from a previous randomized controlled trial…

  8. Cortical circuitry implementing graphical models.

    PubMed

    Litvak, Shai; Ullman, Shimon

    2009-11-01

    In this letter, we develop and simulate a large-scale network of spiking neurons that approximates the inference computations performed by graphical models. Unlike previous related schemes, which used sum and product operations in either the log or linear domains, the current model uses an inference scheme based on the sum and maximization operations in the log domain. Simulations show that using these operations, a large-scale circuit, which combines populations of spiking neurons as basic building blocks, is capable of finding close approximations to the full mathematical computations performed by graphical models within a few hundred milliseconds. The circuit is general in the sense that it can be wired for any graph structure, it supports multistate variables, and it uses standard leaky integrate-and-fire neuronal units. Following previous work, which proposed relations between graphical models and the large-scale cortical anatomy, we focus on the cortical microcircuitry and propose how anatomical and physiological aspects of the local circuitry may map onto elements of the graphical model implementation. We discuss in particular the roles of three major types of inhibitory neurons (small fast-spiking basket cells, large layer 2/3 basket cells, and double-bouquet neurons), subpopulations of strongly interconnected neurons with their unique connectivity patterns in different cortical layers, and the possible role of minicolumns in the realization of the population-based maximum operation.

  9. Anomalously strong observations of PKiKP/PcP amplitude ratios on a global scale

    NASA Astrophysics Data System (ADS)

    Waszek, Lauren; Deuss, Arwen

    2015-07-01

    The inner core boundary marks the phase transition between the solid inner core and the fluid outer core. As the site of inner core solidification, the boundary provides insight into the processes generating the seismic structures of the inner core. In particular, it may hold the key to understanding the previously observed hemispherical asymmetry in inner core seismic velocity, anisotropy, and attenuation. Here we use a large PKiKP-PcP amplitude ratio and travel time residual data set to investigate velocity and density contrast properties near the inner core boundary. Although hemispherical structure at the boundary has been proposed by previous inner core studies, we find no evidence for hemispheres in the amplitude ratios or travel time residuals. In addition, we find that the amplitude ratios are much larger than can be explained by variations in density contrast at the inner core boundary or core-mantle boundary. This indicates that PKiKP is primarily observed when it is anomalously large, due to focusing along its raypath. Using data in which PKiKP is not detected above the noise level, we calculate an upper estimate for the inner core boundary (ICB) density contrast of 1.2 kg m-3. The travel time residuals display large regional variations, which differ on long and short length scales. These regions may be explained by large-scale velocity variations in the F layer just above the inner core boundary, and/or small-scale topography of varying magnitude on the ICB, which also causes the large amplitudes. Such differences could arise from localized freezing and melting of the inner core.

  10. Applications of Magnetic Suspension Technology to Large Scale Facilities: Progress, Problems and Promises

    NASA Technical Reports Server (NTRS)

    Britcher, Colin P.

    1997-01-01

    This paper will briefly review previous work in wind tunnel Magnetic Suspension and Balance Systems (MSBS) and will examine the handful of systems around the world currently known to be in operational condition or undergoing recommissioning. Technical developments emerging from research programs at NASA and elsewhere will be reviewed briefly, where there is potential impact on large-scale MSBSS. The likely aerodynamic applications for large MSBSs will be addressed, since these applications should properly drive system designs. A recently proposed application to ultra-high Reynolds number testing will then be addressed in some detail. Finally, some opinions on the technical feasibility and usefulness of a large MSBS will be given.

  11. The impact of large-scale, long-term optical surveys on pulsating star research

    NASA Astrophysics Data System (ADS)

    Soszyński, Igor

    2017-09-01

    The era of large-scale photometric variability surveys began a quarter of a century ago, when three microlensing projects - EROS, MACHO, and OGLE - started their operation. These surveys initiated a revolution in the field of variable stars and in the next years they inspired many new observational projects. Large-scale optical surveys multiplied the number of variable stars known in the Universe. The huge, homogeneous and complete catalogs of pulsating stars, such as Cepheids, RR Lyrae stars, or long-period variables, offer an unprecedented opportunity to calibrate and test the accuracy of various distance indicators, to trace the three-dimensional structure of the Milky Way and other galaxies, to discover exotic types of intrinsically variable stars, or to study previously unknown features and behaviors of pulsators. We present historical and recent findings on various types of pulsating stars obtained from the optical large-scale surveys, with particular emphasis on the OGLE project which currently offers the largest photometric database among surveys for stellar variability.

  12. Stability of knotted vortices in wave chaos

    NASA Astrophysics Data System (ADS)

    Taylor, Alexander; Dennis, Mark

    Large scale tangles of disordered filaments occur in many diverse physical systems, from turbulent superfluids to optical volume speckle to liquid crystal phases. They can exhibit particular large scale random statistics despite very different local physics. We have previously used the topological statistics of knotting and linking to characterise the large scale tangling, using the vortices of three-dimensional wave chaos as a universal model system whose physical lengthscales are set only by the wavelength. Unlike geometrical quantities, the statistics of knotting depend strongly on the physical system and boundary conditions. Although knotting patterns characterise different systems, the topology of vortices is highly unstable to perturbation, under which they may reconnect with one another. In systems of constructed knots, these reconnections generally rapidly destroy the knot, but for vortex tangles the topological statistics must be stable. Using large scale simulations of chaotic eigenfunctions, we numerically investigate the prevalence and impact of reconnection events, and their effect on the topology of the tangle.

  13. Large-scale self-assembled zirconium phosphate smectic layers via a simple spray-coating process

    NASA Astrophysics Data System (ADS)

    Wong, Minhao; Ishige, Ryohei; White, Kevin L.; Li, Peng; Kim, Daehak; Krishnamoorti, Ramanan; Gunther, Robert; Higuchi, Takeshi; Jinnai, Hiroshi; Takahara, Atsushi; Nishimura, Riichi; Sue, Hung-Jue

    2014-04-01

    The large-scale assembly of asymmetric colloidal particles is used in creating high-performance fibres. A similar concept is extended to the manufacturing of thin films of self-assembled two-dimensional crystal-type materials with enhanced and tunable properties. Here we present a spray-coating method to manufacture thin, flexible and transparent epoxy films containing zirconium phosphate nanoplatelets self-assembled into a lamellar arrangement aligned parallel to the substrate. The self-assembled mesophase of zirconium phosphate nanoplatelets is stabilized by epoxy pre-polymer and exhibits rheology favourable towards large-scale manufacturing. The thermally cured film forms a mechanically robust coating and shows excellent gas barrier properties at both low- and high humidity levels as a result of the highly aligned and overlapping arrangement of nanoplatelets. This work shows that the large-scale ordering of high aspect ratio nanoplatelets is easier to achieve than previously thought and may have implications in the technological applications for similar materials.

  14. Similarity spectra analysis of high-performance jet aircraft noise.

    PubMed

    Neilsen, Tracianne B; Gee, Kent L; Wall, Alan T; James, Michael M

    2013-04-01

    Noise measured in the vicinity of an F-22A Raptor has been compared to similarity spectra found previously to represent mixing noise from large-scale and fine-scale turbulent structures in laboratory-scale jet plumes. Comparisons have been made for three engine conditions using ground-based sideline microphones, which covered a large angular aperture. Even though the nozzle geometry is complex and the jet is nonideally expanded, the similarity spectra do agree with large portions of the measured spectra. Toward the sideline, the fine-scale similarity spectrum is used, while the large-scale similarity spectrum provides a good fit to the area of maximum radiation. Combinations of the two similarity spectra are shown to match the data in between those regions. Surprisingly, a combination of the two is also shown to match the data at the farthest aft angle. However, at high frequencies the degree of congruity between the similarity and the measured spectra changes with engine condition and angle. At the higher engine conditions, there is a systematically shallower measured high-frequency slope, with the largest discrepancy occurring in the regions of maximum radiation.

  15. Comparison of Conjugate Gradient Density Matrix Search and Chebyshev Expansion Methods for Avoiding Diagonalization in Large-Scale Electronic Structure Calculations

    NASA Technical Reports Server (NTRS)

    Bates, Kevin R.; Daniels, Andrew D.; Scuseria, Gustavo E.

    1998-01-01

    We report a comparison of two linear-scaling methods which avoid the diagonalization bottleneck of traditional electronic structure algorithms. The Chebyshev expansion method (CEM) is implemented for carbon tight-binding calculations of large systems and its memory and timing requirements compared to those of our previously implemented conjugate gradient density matrix search (CG-DMS). Benchmark calculations are carried out on icosahedral fullerenes from C60 to C8640 and the linear scaling memory and CPU requirements of the CEM demonstrated. We show that the CPU requisites of the CEM and CG-DMS are similar for calculations with comparable accuracy.

  16. Large Scale Processes and Extreme Floods in Brazil

    NASA Astrophysics Data System (ADS)

    Ribeiro Lima, C. H.; AghaKouchak, A.; Lall, U.

    2016-12-01

    Persistent large scale anomalies in the atmospheric circulation and ocean state have been associated with heavy rainfall and extreme floods in water basins of different sizes across the world. Such studies have emerged in the last years as a new tool to improve the traditional, stationary based approach in flood frequency analysis and flood prediction. Here we seek to advance previous studies by evaluating the dominance of large scale processes (e.g. atmospheric rivers/moisture transport) over local processes (e.g. local convection) in producing floods. We consider flood-prone regions in Brazil as case studies and the role of large scale climate processes in generating extreme floods in such regions is explored by means of observed streamflow, reanalysis data and machine learning methods. The dynamics of the large scale atmospheric circulation in the days prior to the flood events are evaluated based on the vertically integrated moisture flux and its divergence field, which are interpreted in a low-dimensional space as obtained by machine learning techniques, particularly supervised kernel principal component analysis. In such reduced dimensional space, clusters are obtained in order to better understand the role of regional moisture recycling or teleconnected moisture in producing floods of a given magnitude. The convective available potential energy (CAPE) is also used as a measure of local convection activities. We investigate for individual sites the exceedance probability in which large scale atmospheric fluxes dominate the flood process. Finally, we analyze regional patterns of floods and how the scaling law of floods with drainage area responds to changes in the climate forcing mechanisms (e.g. local vs large scale).

  17. Investigating the dependence of SCM simulated precipitation and clouds on the spatial scale of large-scale forcing at SGP [Investigating the scale dependence of SCM simulated precipitation and cloud by using gridded forcing data at SGP

    DOE PAGES

    Tang, Shuaiqi; Zhang, Minghua; Xie, Shaocheng

    2017-08-05

    Large-scale forcing data, such as vertical velocity and advective tendencies, are required to drive single-column models (SCMs), cloud-resolving models, and large-eddy simulations. Previous studies suggest that some errors of these model simulations could be attributed to the lack of spatial variability in the specified domain-mean large-scale forcing. This study investigates the spatial variability of the forcing and explores its impact on SCM simulated precipitation and clouds. A gridded large-scale forcing data during the March 2000 Cloud Intensive Operational Period at the Atmospheric Radiation Measurement program's Southern Great Plains site is used for analysis and to drive the single-column version ofmore » the Community Atmospheric Model Version 5 (SCAM5). When the gridded forcing data show large spatial variability, such as during a frontal passage, SCAM5 with the domain-mean forcing is not able to capture the convective systems that are partly located in the domain or that only occupy part of the domain. This problem has been largely reduced by using the gridded forcing data, which allows running SCAM5 in each subcolumn and then averaging the results within the domain. This is because the subcolumns have a better chance to capture the timing of the frontal propagation and the small-scale systems. As a result, other potential uses of the gridded forcing data, such as understanding and testing scale-aware parameterizations, are also discussed.« less

  18. The influence of cognitive load on spatial search performance.

    PubMed

    Longstaffe, Kate A; Hood, Bruce M; Gilchrist, Iain D

    2014-01-01

    During search, executive function enables individuals to direct attention to potential targets, remember locations visited, and inhibit distracting information. In the present study, we investigated these executive processes in large-scale search. In our tasks, participants searched a room containing an array of illuminated locations embedded in the floor. The participants' task was to press the switches at the illuminated locations on the floor so as to locate a target that changed color when pressed. The perceptual salience of the search locations was manipulated by having some locations flashing and some static. Participants were more likely to search at flashing locations, even when they were explicitly informed that the target was equally likely to be at any location. In large-scale search, attention was captured by the perceptual salience of the flashing lights, leading to a bias to explore these targets. Despite this failure of inhibition, participants were able to restrict returns to previously visited locations, a measure of spatial memory performance. Participants were more able to inhibit exploration to flashing locations when they were not required to remember which locations had previously been visited. A concurrent digit-span memory task further disrupted inhibition during search, as did a concurrent auditory attention task. These experiments extend a load theory of attention to large-scale search, which relies on egocentric representations of space. High cognitive load on working memory leads to increased distractor interference, providing evidence for distinct roles for the executive subprocesses of memory and inhibition during large-scale search.

  19. Enabling large-scale viscoelastic calculations via neural network acceleration

    NASA Astrophysics Data System (ADS)

    Robinson DeVries, P.; Thompson, T. B.; Meade, B. J.

    2017-12-01

    One of the most significant challenges involved in efforts to understand the effects of repeated earthquake cycle activity are the computational costs of large-scale viscoelastic earthquake cycle models. Deep artificial neural networks (ANNs) can be used to discover new, compact, and accurate computational representations of viscoelastic physics. Once found, these efficient ANN representations may replace computationally intensive viscoelastic codes and accelerate large-scale viscoelastic calculations by more than 50,000%. This magnitude of acceleration enables the modeling of geometrically complex faults over thousands of earthquake cycles across wider ranges of model parameters and at larger spatial and temporal scales than have been previously possible. Perhaps most interestingly from a scientific perspective, ANN representations of viscoelastic physics may lead to basic advances in the understanding of the underlying model phenomenology. We demonstrate the potential of artificial neural networks to illuminate fundamental physical insights with specific examples.

  20. Porous microwells for geometry-selective, large-scale microparticle arrays

    NASA Astrophysics Data System (ADS)

    Kim, Jae Jung; Bong, Ki Wan; Reátegui, Eduardo; Irimia, Daniel; Doyle, Patrick S.

    2017-01-01

    Large-scale microparticle arrays (LSMAs) are key for material science and bioengineering applications. However, previous approaches suffer from trade-offs between scalability, precision, specificity and versatility. Here, we present a porous microwell-based approach to create large-scale microparticle arrays with complex motifs. Microparticles are guided to and pushed into microwells by fluid flow through small open pores at the bottom of the porous well arrays. A scaling theory allows for the rational design of LSMAs to sort and array particles on the basis of their size, shape, or modulus. Sequential particle assembly allows for proximal and nested particle arrangements, as well as particle recollection and pattern transfer. We demonstrate the capabilities of the approach by means of three applications: high-throughput single-cell arrays; microenvironment fabrication for neutrophil chemotaxis; and complex, covert tags by the transfer of an upconversion nanocrystal-laden LSMA.

  1. Turbulent mass transfer caused by vortex induced reconnection in collisionless magnetospheric plasmas.

    PubMed

    Nakamura, T K M; Hasegawa, H; Daughton, W; Eriksson, S; Li, W Y; Nakamura, R

    2017-11-17

    Magnetic reconnection is believed to be the main driver to transport solar wind into the Earth's magnetosphere when the magnetopause features a large magnetic shear. However, even when the magnetic shear is too small for spontaneous reconnection, the Kelvin-Helmholtz instability driven by a super-Alfvénic velocity shear is expected to facilitate the transport. Although previous kinetic simulations have demonstrated that the non-linear vortex flows from the Kelvin-Helmholtz instability gives rise to vortex-induced reconnection and resulting plasma transport, the system sizes of these simulations were too small to allow the reconnection to evolve much beyond the electron scale as recently observed by the Magnetospheric Multiscale (MMS) spacecraft. Here, based on a large-scale kinetic simulation and its comparison with MMS observations, we show for the first time that ion-scale jets from vortex-induced reconnection rapidly decay through self-generated turbulence, leading to a mass transfer rate nearly one order higher than previous expectations for the Kelvin-Helmholtz instability.

  2. Large-scale assembly bias of dark matter halos

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lazeyras, Titouan; Musso, Marcello; Schmidt, Fabian, E-mail: titouan@mpa-garching.mpg.de, E-mail: mmusso@sas.upenn.edu, E-mail: fabians@mpa-garching.mpg.de

    We present precise measurements of the assembly bias of dark matter halos, i.e. the dependence of halo bias on other properties than the mass, using curved 'separate universe' N-body simulations which effectively incorporate an infinite-wavelength matter overdensity into the background density. This method measures the LIMD (local-in-matter-density) bias parameters b {sub n} in the large-scale limit. We focus on the dependence of the first two Eulerian biases b {sup E} {sup {sub 1}} and b {sup E} {sup {sub 2}} on four halo properties: the concentration, spin, mass accretion rate, and ellipticity. We quantitatively compare our results with previous worksmore » in which assembly bias was measured on fairly small scales. Despite this difference, our findings are in good agreement with previous results. We also look at the joint dependence of bias on two halo properties in addition to the mass. Finally, using the excursion set peaks model, we attempt to shed new insights on how assembly bias arises in this analytical model.« less

  3. Multi-scale geophysical study to model the distribution and development of fractures in relation to the knickpoint in the Luquillo Critical Zone Observatory (Puerto Rico)

    NASA Astrophysics Data System (ADS)

    Comas, X.; Wright, W. J.; Hynek, S. A.; Ntarlagiannis, D.; Terry, N.; Job, M. J.; Fletcher, R. C.; Brantley, S.

    2017-12-01

    Previous studies in the Rio Icacos watershed in the Luquillo Mountains (Puerto Rico) have shown that regolith materials are rapidly developed from the alteration of quartz diorite bedrock, and create a blanket on top of the bedrock with a thickness that decreases with proximity to the knickpoint. The watershed is also characterized by a system of heterogeneous fractures that likely drive bedrock weathering and the formation of corestones and associated spheroidal fracturing and rindlets. Previous efforts to characterize the spatial distribution of fractures were based on aerial images that did not account for the architecture of the critical zone below the subsurface. In this study we use an array of near-surface geophysical methods at multiple scales to better understand how the spatial distribution and density of fractures varies with topography and proximity to the knickpoint. Large km-scale surveys using ground penetrating radar (GPR), terrain conductivity, and capacitively coupled resistivity, were combined with smaller scale surveys (10-100 m) using electrical resistivity imaging (ERI), and shallow seismics, and were directly constrained with boreholes from previous studies. Geophysical results were compared to theoretical models of compressive stress as due to gravity and regional compression, and showed consistency at describing increased dilation of fractures with proximity to the knickpoint. This study shows the potential of multidisciplinary approaches to model critical zone processes at multiple scales of measurement and high spatial resolution. The approach can be particularly efficient at large km-scales when applying geophysical methods that allow for rapid data acquisition (i.e. walking pace) at high spatial resolution (i.e. cm scales).

  4. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kim, Junghyun; Gangwon, Jo; Jaehoon, Jung

    Applications written solely in OpenCL or CUDA cannot execute on a cluster as a whole. Most previous approaches that extend these programming models to clusters are based on a common idea: designating a centralized host node and coordinating the other nodes with the host for computation. However, the centralized host node is a serious performance bottleneck when the number of nodes is large. In this paper, we propose a scalable and distributed OpenCL framework called SnuCL-D for large-scale clusters. SnuCL-D's remote device virtualization provides an OpenCL application with an illusion that all compute devices in a cluster are confined inmore » a single node. To reduce the amount of control-message and data communication between nodes, SnuCL-D replicates the OpenCL host program execution and data in each node. We also propose a new OpenCL host API function and a queueing optimization technique that significantly reduce the overhead incurred by the previous centralized approaches. To show the effectiveness of SnuCL-D, we evaluate SnuCL-D with a microbenchmark and eleven benchmark applications on a large-scale CPU cluster and a medium-scale GPU cluster.« less

  5. The ellipsoidal universe in the Planck satellite era

    NASA Astrophysics Data System (ADS)

    Cea, Paolo

    2014-06-01

    Recent Planck data confirm that the cosmic microwave background displays the quadrupole power suppression together with large-scale anomalies. Progressing from previous results, that focused on the quadrupole anomaly, we strengthen the proposal that the slightly anisotropic ellipsoidal universe may account for these anomalies. We solved at large scales the Boltzmann equation for the photon distribution functions by taking into account both the effects of the inflation produced primordial scalar perturbations and the anisotropy of the geometry in the ellipsoidal universe. We showed that the low quadrupole temperature correlations allowed us to fix the eccentricity at decoupling, edec = (0.86 ± 0.14) 10-2, and to constraint the direction of the symmetry axis. We found that the anisotropy of the geometry of the universe contributes only to the large-scale temperature anisotropies without affecting the higher multipoles of the angular power spectrum. Moreover, we showed that the ellipsoidal geometry of the universe induces sizeable polarization signal at large scales without invoking the reionization scenario. We explicitly evaluated the quadrupole TE and EE correlations. We found an average large-scale polarization ΔTpol = (1.20 ± 0.38) μK. We point out that great care is needed in the experimental determination of the large-scale polarization correlations since the average temperature polarization could be misinterpreted as foreground emission leading, thereby, to a considerable underestimate of the cosmic microwave background polarization signal.

  6. The Emergence of a Learning Progression in Middle School Chemistry

    ERIC Educational Resources Information Center

    Johnson, Philip; Tymms, Peter

    2011-01-01

    Previously, a small scale, interview-based, 3-year longitudinal study (ages 11-14) in one school had suggested a learning progression related to the concept of a substance. This article presents the results of a large-scale, cross-sectional study which used Rasch modeling to test the hypothesis of the learning progression. Data were collected from…

  7. Satisfaction with Life and Hope: A Look at Age and Marital Status

    ERIC Educational Resources Information Center

    Bailey, Thomas C.; Snyder, C. R.

    2007-01-01

    The Adult Trait Hope Scale (Snyder et al., 1991) typically has been administered to samples of college students, and previous researchers have not explored key demographic variables. In a large sample of community persons who were not in college (N = 215), significant differences were detected in Hope Scale scores across differing age groups and…

  8. Investigating measurement equivalence of visual analogue scales and Likert-type scales in Internet-based personality questionnaires.

    PubMed

    Kuhlmann, Tim; Dantlgraber, Michael; Reips, Ulf-Dietrich

    2017-12-01

    Visual analogue scales (VASs) have shown superior measurement qualities in comparison to traditional Likert-type response scales in previous studies. The present study expands the comparison of response scales to properties of Internet-based personality scales in a within-subjects design. A sample of 879 participants filled out an online questionnaire measuring Conscientiousness, Excitement Seeking, and Narcissism. The questionnaire contained all instruments in both answer scale versions in a counterbalanced design. Results show comparable reliabilities, means, and SDs for the VAS versions of the original scales, in comparison to Likert-type scales. To assess the validity of the measurements, age and gender were used as criteria, because all three constructs have shown non-zero correlations with age and gender in previous research. Both response scales showed a high overlap and the proposed relationships with age and gender. The associations were largely identical, with the exception of an increase in explained variance when predicting age from the VAS version of Excitement Seeking (B10 = 1318.95, ΔR(2) = .025). VASs showed similar properties to Likert-type response scales in most cases.

  9. An Application of Hydraulic Tomography to a Large-Scale Fractured Granite Site, Mizunami, Japan.

    PubMed

    Zha, Yuanyuan; Yeh, Tian-Chyi J; Illman, Walter A; Tanaka, Tatsuya; Bruines, Patrick; Onoe, Hironori; Saegusa, Hiromitsu; Mao, Deqiang; Takeuchi, Shinji; Wen, Jet-Chau

    2016-11-01

    While hydraulic tomography (HT) is a mature aquifer characterization technology, its applications to characterize hydrogeology of kilometer-scale fault and fracture zones are rare. This paper sequentially analyzes datasets from two new pumping tests as well as those from two previous pumping tests analyzed by Illman et al. (2009) at a fractured granite site in Mizunami, Japan. Results of this analysis show that datasets from two previous pumping tests at one side of a fault zone as used in the previous study led to inaccurate mapping of fracture and fault zones. Inclusion of the datasets from the two new pumping tests (one of which was conducted on the other side of the fault) yields locations of the fault zone consistent with those based on geological mapping. The new datasets also produce a detailed image of the irregular fault zone, which is not available from geological investigation alone and the previous study. As a result, we conclude that if prior knowledge about geological structures at a field site is considered during the design of HT surveys, valuable non-redundant datasets about the fracture and fault zones can be collected. Only with these non-redundant data sets, can HT then be a viable and robust tool for delineating fracture and fault distributions over kilometer scales, even when only a limited number of boreholes are available. In essence, this paper proves that HT is a new tool for geologists, geophysicists, and engineers for mapping large-scale fracture and fault zone distributions. © 2016, National Ground Water Association.

  10. 'Thunder' - Shock waves in pre-biological organic synthesis.

    NASA Technical Reports Server (NTRS)

    Bar-Nun, A.; Tauber, M. E.

    1972-01-01

    Theoretical study of the gasdynamics and chemistry of lightning-produced shock waves in a postulated primordial reducing atmosphere. It is shown that the conditions are similar to those encountered in a previously performed shock-tube experiment which resulted in 36% of the ammonia in the original mixture being converted into amino acids. The calculations give the (very large) energy rate of about 0.4 cal/sq cm/yr available for amino acid production, supporting previous hypotheses that 'thunder' could have been responsible for efficient large-scale production of organic molecules serving as precursors of life.

  11. Soil and tree ring chemistry changes in an oak forest.

    Treesearch

    Quentin D. Read

    2009-01-01

    Changes in soil chemistry due to historic large-scale disturbances, e.g. pollution inputs, storm damage, and logging, have previously been shown to cause similar changes in the nutrient concentrations...

  12. Investigating the Impact of Surface Heterogeneity on the Convective Boundary Layer Over Urban Areas Through Coupled Large-Eddy Simulation and Remote Sensing

    NASA Technical Reports Server (NTRS)

    Dominguez, Anthony; Kleissl, Jan P.; Luvall, Jeffrey C.

    2011-01-01

    Large-eddy Simulation (LES) was used to study convective boundary layer (CBL) flow through suburban regions with both large and small scale heterogeneities in surface temperature. Constant remotely sensed surface temperatures were applied at the surface boundary at resolutions of 10 m, 90 m, 200 m, and 1 km. Increasing the surface resolution from 1 km to 200 m had the most significant impact on the mean and turbulent flow characteristics as the larger scale heterogeneities became resolved. While previous studies concluded that scales of heterogeneity much smaller than the CBL inversion height have little impact on the CBL characteristics, we found that further increasing the surface resolution (resolving smaller scale heterogeneities) results in an increase in mean surface heat flux, thermal blending height, and potential temperature profile. The results of this study will help to better inform sub-grid parameterization for meso-scale meteorological models. The simulation tool developed through this study (combining LES and high resolution remotely sensed surface conditions) is a significant step towards future studies on the micro-scale meteorology in urban areas.

  13. Food waste impact on municipal solid waste angle of internal friction.

    PubMed

    Cho, Young Min; Ko, Jae Hac; Chi, Liqun; Townsend, Timothy G

    2011-01-01

    The impact of food waste content on the municipal solid waste (MSW) friction angle was studied. Using reconstituted fresh MSW specimens with different food waste content (0%, 40%, 58%, and 80%), 48 small-scale (100-mm-diameter) direct shear tests and 12 large-scale (430 mm × 430 mm) direct shear tests were performed. A stress-controlled large-scale direct shear test device allowing approximately 170-mm sample horizontal displacement was designed and used. At both testing scales, the mobilized internal friction angle of MSW decreased considerably as food waste content increased. As food waste content increased from 0% to 40% and from 40% to 80%, the mobilized internal friction angles (estimated using the mobilized peak (ultimate) shear strengths of the small-scale direct shear tests) decreased from 39° to 31° and from 31° to 7°, respectively, while those of large-scale tests decreased from 36° to 26° and from 26° to 15°, respectively. Most friction angle measurements produced in this study fell within the range of those previously reported for MSW. Copyright © 2010 Elsevier Ltd. All rights reserved.

  14. Channel optimization of high-intensity laser beams in millimeter-scale plasmas.

    PubMed

    Ceurvorst, L; Savin, A; Ratan, N; Kasim, M F; Sadler, J; Norreys, P A; Habara, H; Tanaka, K A; Zhang, S; Wei, M S; Ivancic, S; Froula, D H; Theobald, W

    2018-04-01

    Channeling experiments were performed at the OMEGA EP facility using relativistic intensity (>10^{18}W/cm^{2}) kilojoule laser pulses through large density scale length (∼390-570 μm) laser-produced plasmas, demonstrating the effects of the pulse's focal location and intensity as well as the plasma's temperature on the resulting channel formation. The results show deeper channeling when focused into hot plasmas and at lower densities, as expected. However, contrary to previous large-scale particle-in-cell studies, the results also indicate deeper penetration by short (10 ps), intense pulses compared to their longer-duration equivalents. This new observation has many implications for future laser-plasma research in the relativistic regime.

  15. Channel optimization of high-intensity laser beams in millimeter-scale plasmas

    NASA Astrophysics Data System (ADS)

    Ceurvorst, L.; Savin, A.; Ratan, N.; Kasim, M. F.; Sadler, J.; Norreys, P. A.; Habara, H.; Tanaka, K. A.; Zhang, S.; Wei, M. S.; Ivancic, S.; Froula, D. H.; Theobald, W.

    2018-04-01

    Channeling experiments were performed at the OMEGA EP facility using relativistic intensity (>1018W/cm 2 ) kilojoule laser pulses through large density scale length (˜390 -570 μ m ) laser-produced plasmas, demonstrating the effects of the pulse's focal location and intensity as well as the plasma's temperature on the resulting channel formation. The results show deeper channeling when focused into hot plasmas and at lower densities, as expected. However, contrary to previous large-scale particle-in-cell studies, the results also indicate deeper penetration by short (10 ps), intense pulses compared to their longer-duration equivalents. This new observation has many implications for future laser-plasma research in the relativistic regime.

  16. The small-scale dynamo: breaking universality at high Mach numbers

    NASA Astrophysics Data System (ADS)

    Schleicher, Dominik R. G.; Schober, Jennifer; Federrath, Christoph; Bovino, Stefano; Schmidt, Wolfram

    2013-02-01

    The small-scale dynamo plays a substantial role in magnetizing the Universe under a large range of conditions, including subsonic turbulence at low Mach numbers, highly supersonic turbulence at high Mach numbers and a large range of magnetic Prandtl numbers Pm, i.e. the ratio of kinetic viscosity to magnetic resistivity. Low Mach numbers may, in particular, lead to the well-known, incompressible Kolmogorov turbulence, while for high Mach numbers, we are in the highly compressible regime, thus close to Burgers turbulence. In this paper, we explore whether in this large range of conditions, universal behavior can be expected. Our starting point is previous investigations in the kinematic regime. Here, analytic studies based on the Kazantsev model have shown that the behavior of the dynamo depends significantly on Pm and the type of turbulence, and numerical simulations indicate a strong dependence of the growth rate on the Mach number of the flow. Once the magnetic field saturates on the current amplification scale, backreactions occur and the growth is shifted to the next-larger scale. We employ a Fokker-Planck model to calculate the magnetic field amplification during the nonlinear regime, and find a resulting power-law growth that depends on the type of turbulence invoked. For Kolmogorov turbulence, we confirm previous results suggesting a linear growth of magnetic energy. For more general turbulent spectra, where the turbulent velocity scales with the characteristic length scale as uℓ∝ℓϑ, we find that the magnetic energy grows as (t/Ted)2ϑ/(1-ϑ), with t being the time coordinate and Ted the eddy-turnover time on the forcing scale of turbulence. For Burgers turbulence, ϑ = 1/2, quadratic rather than linear growth may thus be expected, as the spectral energy increases from smaller to larger scales more rapidly. The quadratic growth is due to the initially smaller growth rates obtained for Burgers turbulence. Similarly, we show that the characteristic length scale of the magnetic field grows as t1/(1-ϑ) in the general case, implying t3/2 for Kolmogorov and t2 for Burgers turbulence. Overall, we find that high Mach numbers, as typically associated with steep spectra of turbulence, may break the previously postulated universality, and introduce a dependence on the environment also in the nonlinear regime.

  17. Hysteresis-Free Carbon Nanotube Field-Effect Transistors.

    PubMed

    Park, Rebecca S; Hills, Gage; Sohn, Joon; Mitra, Subhasish; Shulaker, Max M; Wong, H-S Philip

    2017-05-23

    While carbon nanotube (CNT) field-effect transistors (CNFETs) promise high-performance and energy-efficient digital systems, large hysteresis degrades these potential CNFET benefits. As hysteresis is caused by traps surrounding the CNTs, previous works have shown that clean interfaces that are free of traps are important to minimize hysteresis. Our previous findings on the sources and physics of hysteresis in CNFETs enabled us to understand the influence of gate dielectric scaling on hysteresis. To begin with, we validate through simulations how scaling the gate dielectric thickness results in greater-than-expected benefits in reducing hysteresis. Leveraging this insight, we experimentally demonstrate reducing hysteresis to <0.5% of the gate-source voltage sweep range using a very large-scale integration compatible and solid-state technology, simply by fabricating CNFETs with a thin effective oxide thickness of 1.6 nm. However, even with negligible hysteresis, large subthreshold swing is still observed in the CNFETs with multiple CNTs per transistor. We show that the cause of large subthreshold swing is due to threshold voltage variation between individual CNTs. We also show that the source of this threshold voltage variation is not explained solely by variations in CNT diameters (as is often ascribed). Rather, other factors unrelated to the CNTs themselves (i.e., process variations, random fixed charges at interfaces) are a significant factor in CNT threshold voltage variations and thus need to be further improved.

  18. Use of Analogy in Learning Physics: The Role of Representations

    ERIC Educational Resources Information Center

    Podolefsky, Noah S.; Finkelstein, Naoh D.

    2006-01-01

    Previous studies have demonstrated that analogies can promote student learning in physics and can be productively taught to students to support their learning, under certain conditions. We build on these studies to explore the use of analogy by students in a large introductory college physics course. In the first large-scale study of its kind, we…

  19. Potential climatic impacts and reliability of large-scale offshore wind farms

    NASA Astrophysics Data System (ADS)

    Wang, Chien; Prinn, Ronald G.

    2011-04-01

    The vast availability of wind power has fueled substantial interest in this renewable energy source as a potential near-zero greenhouse gas emission technology for meeting future world energy needs while addressing the climate change issue. However, in order to provide even a fraction of the estimated future energy needs, a large-scale deployment of wind turbines (several million) is required. The consequent environmental impacts, and the inherent reliability of such a large-scale usage of intermittent wind power would have to be carefully assessed, in addition to the need to lower the high current unit wind power costs. Our previous study (Wang and Prinn 2010 Atmos. Chem. Phys. 10 2053) using a three-dimensional climate model suggested that a large deployment of wind turbines over land to meet about 10% of predicted world energy needs in 2100 could lead to a significant temperature increase in the lower atmosphere over the installed regions. A global-scale perturbation to the general circulation patterns as well as to the cloud and precipitation distribution was also predicted. In the later study reported here, we conducted a set of six additional model simulations using an improved climate model to further address the potential environmental and intermittency issues of large-scale deployment of offshore wind turbines for differing installation areas and spatial densities. In contrast to the previous land installation results, the offshore wind turbine installations are found to cause a surface cooling over the installed offshore regions. This cooling is due principally to the enhanced latent heat flux from the sea surface to lower atmosphere, driven by an increase in turbulent mixing caused by the wind turbines which was not entirely offset by the concurrent reduction of mean wind kinetic energy. We found that the perturbation of the large-scale deployment of offshore wind turbines to the global climate is relatively small compared to the case of land-based installations. However, the intermittency caused by the significant seasonal wind variations over several major offshore sites is substantial, and demands further options to ensure the reliability of large-scale offshore wind power. The method that we used to simulate the offshore wind turbine effect on the lower atmosphere involved simply increasing the ocean surface drag coefficient. While this method is consistent with several detailed fine-scale simulations of wind turbines, it still needs further study to ensure its validity. New field observations of actual wind turbine arrays are definitely required to provide ultimate validation of the model predictions presented here.

  20. Magnetic anomaly map of the central Cayman Trough, northwestern Caribbean Sea

    USGS Publications Warehouse

    Dillon, William P.; Edgar, N. Terence; Parson, Lindsay M.; Scanlon, Kathryn M.; Driscoll, George R.; Jacobs, Colin L.

    1993-01-01

    This is the first large-scale published map of magnetic anomalies in the central Cayman Trough area. Two previously published very small scale maps based on much less data are a regional map (Gough and Heirtzler, 1969) and a map compiled from several tracklines running parallel to the axis of the Cayman Trough (MacDonald and Holcombe, 1978).

  1. The observation of possible reconnection events in the boundary changes of solar coronal holes

    NASA Technical Reports Server (NTRS)

    Kahler, S. W.; Moses, J. Daniel

    1989-01-01

    Coronal holes are large scale regions of magnetically open fields which are easily observed in solar soft X-ray images. The boundaries of coronal holes are separatrices between large scale regions of open and closed magnetic fields where one might expect to observe evidence of solar magnetic reconnection. Previous studies by Nolte and colleagues using Skylab X-ray images established that large scale (greater than or equal to 9 x 10(4) km) changes in coronal hole boundaries were due to coronal processes, i.e., magnetic reconnection, rather than to photospheric motions. Those studies were limited to time scales of about one day, and no conclusion could be drawn about the size and time scales of the reconnection process at hole boundaries. Sequences of appropriate Skylab X-ray images were used with a time resolution of about 90 min during times of the central meridian passages of the coronal hole labelled Coronal Hole 1 to search for hole boundary changes which can yield the spatial and temporal scales of coronal magnetic reconnection. It was found that 29 of 32 observed boundary changes could be associated with bright points. The appearance of the bright point may be the signature of reconnection between small scale and large scale magnetic fields. The observed boundary changes contributed to the quasi-rigid rotation of Coronal Hole 1.

  2. Deep X-ray Observations of an Ongoing Merger and 400 Myr of AGN Activity in Cygnus A

    NASA Astrophysics Data System (ADS)

    Wise, Michael W.; De Vries, Martijn; Nulsen, Paul; Snios, Bradford; Birkinshaw, Mark; Worrall, Diana; Duffy, Ryan; Halbesma, Timo; Donnert, Julius; Hardcastle, Martin

    2017-08-01

    We present a detailed spatial and spectral analysis of the large-scale X-ray emission associated with the merging cluster of galaxies containing the powerful Cygnus A radio galaxy. Using a new 1 Msec exposure from the ongoing Chandra XVP project, we have mapped the large-scale structure, temperature and abundance of the ICM in a 1 Mpc x 1 Mpc region surrounding Cygnus A. This new, deep exposure resolves unprecedented detail in the jets, lobes, and cocoon shock associated with Cygnus A, and provides new insights into the emission mechanisms that produce these features as well as implications for the ongoing activity of the central AGN. On larger scales, these new data reveal complex and dramatic temperature, pressure, entropy and metallicity structure in the ICM surrounding Cygnus A. We confirm the presence of large-scale X-ray emission associated with the two merging cluster components seen previously in lower resolution data. The temperature structure on the scale of the merger exhibits an asymmetric enhancement to the NW consistent with projected hotter gas from the merger shock. Using the derived density and temperature profiles in the two merging sub-cluster components as inputs, we have constructed a grid of hydro-dynamical simulations to constrain the geometry of the merger system. These models imply a pre-merger system with a 1:1 mass ratio at the virial radius with an inclination toward the line of sight of 35-45 deg. In addition to the merger-induced temperature asymmetry, we find evidence for additional surface brightness and temperature features indicative of previous outburst activity in Cygnus A over the past 400 Myr. Based on the location and strength of these features, we derive the energy associated with these previous outbursts and place constraints on the growth of the black hole in Cygnus A over that timescale.

  3. Planck 2015 results: XXI. The integrated Sachs-Wolfe effect

    DOE PAGES

    Ade, P. A. R.; Aghanim, N.; Arnaud, M.; ...

    2016-09-20

    Here, this paper presents a study of the integrated Sachs-Wolfe (ISW) effect from the Planck 2015 temperature and polarization data release. This secondary cosmic microwave background (CMB) anisotropy caused by the large-scale time-evolving gravitational potential is probed from different perspectives. The CMB is cross-correlated with different large-scale structure (LSS) tracers: radio sources from the NVSS catalogue; galaxies from the optical SDSS and the infrared WISE surveys; and the Planck 2015 convergence lensing map. The joint cross-correlation of the CMB with the tracers yields a detection at 4σ where most of the signal-to-noise is due to the Planck lensing and themore » NVSS radio catalogue. In fact, the ISW effect is detected from the Planck data only at ≈3σ (through the ISW-lensing bispectrum), which is similar to the detection level achieved by combining the cross-correlation signal coming from all the galaxy catalogues mentioned above. We study the ability of the ISW effect to place constraints on the dark-energy parameters; in particular, we show that Ω Λ is detected at more than 3σ. This cross-correlation analysis is performed only with the Planck temperature data, since the polarization scales available in the 2015 release do not permit significant improvement of the CMB-LSS cross-correlation detectability. Nevertheless, the Planck polarization data are used to study the anomalously large ISW signal previously reported through the aperture photometry on stacked CMB features at the locations of known superclusters and supervoids, which is in conflict with ΛCDM expectations. We find that the current Planck polarization data do not exclude that this signal could be caused by the ISW effect. In addition, the stacking of the Planck lensing map on the locations of superstructures exhibits a positive cross-correlation with these large-scale structures. Finally, we have improved our previous reconstruction of the ISW temperature fluctuations by combining the information encoded in all the previously mentioned LSS tracers. In particular, we construct a map of the ISW secondary anisotropies and the corresponding uncertainties map, obtained from simulations. Lastly, we also explore the reconstruction of the ISW anisotropies caused by the large-scale structure traced by the 2MASS Photometric Redshift Survey (2MPZ) by directly inverting the density field into the gravitational potential field.« less

  4. Planck 2015 results. XXI. The integrated Sachs-Wolfe effect

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Arnaud, M.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Bartolo, N.; Basak, S.; Battaner, E.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bock, J. J.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Bucher, M.; Burigana, C.; Butler, R. C.; Calabrese, E.; Cardoso, J.-F.; Casaponsa, B.; Catalano, A.; Challinor, A.; Chamballu, A.; Chiang, H. C.; Christensen, P. R.; Church, S.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Combet, C.; Couchot, F.; Coulais, A.; Crill, B. P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Désert, F.-X.; Diego, J. M.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Ducout, A.; Dupac, X.; Efstathiou, G.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Fergusson, J.; Fernandez-Cobos, R.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Frejsel, A.; Galeotta, S.; Galli, S.; Ganga, K.; Génova-Santos, R. T.; Giard, M.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Gudmundsson, J. E.; Hansen, F. K.; Hanson, D.; Harrison, D. L.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Hurier, G.; Ilić, S.; Jaffe, A. H.; Jaffe, T. R.; Jones, W. C.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Langer, M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Leonardi, R.; Lesgourgues, J.; Levrier, F.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Ma, Y.-Z.; Macías-Pérez, J. F.; Maggio, G.; Maino, D.; Mandolesi, N.; Mangilli, A.; Marcos-Caballero, A.; Maris, M.; Martin, P. G.; Martínez-González, E.; Masi, S.; Matarrese, S.; McGehee, P.; Meinhold, P. R.; Melchiorri, A.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mitra, S.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Oxborrow, C. A.; Paci, F.; Pagano, L.; Pajot, F.; Paoletti, D.; Pasian, F.; Patanchon, G.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Popa, L.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Reach, W. T.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Roudier, G.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Santos, D.; Savelainen, M.; Savini, G.; Schaefer, B. M.; Scott, D.; Seiffert, M. D.; Shellard, E. P. S.; Spencer, L. D.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sunyaev, R.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Tuovinen, J.; Valenziano, L.; Valiviita, J.; Van Tent, F.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Wehus, I. K.; Yvon, D.; Zacchei, A.; Zonca, A.

    2016-09-01

    This paper presents a study of the integrated Sachs-Wolfe (ISW) effect from the Planck 2015 temperature and polarization data release. This secondary cosmic microwave background (CMB) anisotropy caused by the large-scale time-evolving gravitational potential is probed from different perspectives. The CMB is cross-correlated with different large-scale structure (LSS) tracers: radio sources from the NVSS catalogue; galaxies from the optical SDSS and the infrared WISE surveys; and the Planck 2015 convergence lensing map. The joint cross-correlation of the CMB with the tracers yields a detection at 4σ where most of the signal-to-noise is due to the Planck lensing and the NVSS radio catalogue. In fact, the ISW effect is detected from the Planck data only at ≈3σ (through the ISW-lensing bispectrum), which is similar to the detection level achieved by combining the cross-correlation signal coming from all the galaxy catalogues mentioned above. We study the ability of the ISW effect to place constraints on the dark-energy parameters; in particular, we show that ΩΛ is detected at more than 3σ. This cross-correlation analysis is performed only with the Planck temperature data, since the polarization scales available in the 2015 release do not permit significant improvement of the CMB-LSS cross-correlation detectability. Nevertheless, the Planck polarization data are used to study the anomalously large ISW signal previously reported through the aperture photometry on stacked CMB features at the locations of known superclusters and supervoids, which is in conflict with ΛCDM expectations. We find that the current Planck polarization data do not exclude that this signal could be caused by the ISW effect. In addition, the stacking of the Planck lensing map on the locations of superstructures exhibits a positive cross-correlation with these large-scale structures. Finally, we have improved our previous reconstruction of the ISW temperature fluctuations by combining the information encoded in all the previously mentioned LSS tracers. In particular, we construct a map of the ISW secondary anisotropies and the corresponding uncertainties map, obtained from simulations. We also explore the reconstruction of the ISW anisotropies caused by the large-scale structure traced by the 2MASS Photometric Redshift Survey (2MPZ) by directly inverting the density field into the gravitational potential field.

  5. Planck 2015 results: XXI. The integrated Sachs-Wolfe effect

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ade, P. A. R.; Aghanim, N.; Arnaud, M.

    Here, this paper presents a study of the integrated Sachs-Wolfe (ISW) effect from the Planck 2015 temperature and polarization data release. This secondary cosmic microwave background (CMB) anisotropy caused by the large-scale time-evolving gravitational potential is probed from different perspectives. The CMB is cross-correlated with different large-scale structure (LSS) tracers: radio sources from the NVSS catalogue; galaxies from the optical SDSS and the infrared WISE surveys; and the Planck 2015 convergence lensing map. The joint cross-correlation of the CMB with the tracers yields a detection at 4σ where most of the signal-to-noise is due to the Planck lensing and themore » NVSS radio catalogue. In fact, the ISW effect is detected from the Planck data only at ≈3σ (through the ISW-lensing bispectrum), which is similar to the detection level achieved by combining the cross-correlation signal coming from all the galaxy catalogues mentioned above. We study the ability of the ISW effect to place constraints on the dark-energy parameters; in particular, we show that Ω Λ is detected at more than 3σ. This cross-correlation analysis is performed only with the Planck temperature data, since the polarization scales available in the 2015 release do not permit significant improvement of the CMB-LSS cross-correlation detectability. Nevertheless, the Planck polarization data are used to study the anomalously large ISW signal previously reported through the aperture photometry on stacked CMB features at the locations of known superclusters and supervoids, which is in conflict with ΛCDM expectations. We find that the current Planck polarization data do not exclude that this signal could be caused by the ISW effect. In addition, the stacking of the Planck lensing map on the locations of superstructures exhibits a positive cross-correlation with these large-scale structures. Finally, we have improved our previous reconstruction of the ISW temperature fluctuations by combining the information encoded in all the previously mentioned LSS tracers. In particular, we construct a map of the ISW secondary anisotropies and the corresponding uncertainties map, obtained from simulations. Lastly, we also explore the reconstruction of the ISW anisotropies caused by the large-scale structure traced by the 2MASS Photometric Redshift Survey (2MPZ) by directly inverting the density field into the gravitational potential field.« less

  6. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tang, Shuaiqi; Zhang, Minghua; Xie, Shaocheng

    Large-scale forcing data, such as vertical velocity and advective tendencies, are required to drive single-column models (SCMs), cloud-resolving models, and large-eddy simulations. Previous studies suggest that some errors of these model simulations could be attributed to the lack of spatial variability in the specified domain-mean large-scale forcing. This study investigates the spatial variability of the forcing and explores its impact on SCM simulated precipitation and clouds. A gridded large-scale forcing data during the March 2000 Cloud Intensive Operational Period at the Atmospheric Radiation Measurement program's Southern Great Plains site is used for analysis and to drive the single-column version ofmore » the Community Atmospheric Model Version 5 (SCAM5). When the gridded forcing data show large spatial variability, such as during a frontal passage, SCAM5 with the domain-mean forcing is not able to capture the convective systems that are partly located in the domain or that only occupy part of the domain. This problem has been largely reduced by using the gridded forcing data, which allows running SCAM5 in each subcolumn and then averaging the results within the domain. This is because the subcolumns have a better chance to capture the timing of the frontal propagation and the small-scale systems. As a result, other potential uses of the gridded forcing data, such as understanding and testing scale-aware parameterizations, are also discussed.« less

  7. Large perceptual distortions of locomotor action space occur in ground-based coordinates: Angular expansion and the large-scale horizontal-vertical illusion.

    PubMed

    Klein, Brennan J; Li, Zhi; Durgin, Frank H

    2016-04-01

    What is the natural reference frame for seeing large-scale spatial scenes in locomotor action space? Prior studies indicate an asymmetric angular expansion in perceived direction in large-scale environments: Angular elevation relative to the horizon is perceptually exaggerated by a factor of 1.5, whereas azimuthal direction is exaggerated by a factor of about 1.25. Here participants made angular and spatial judgments when upright or on their sides to dissociate egocentric from allocentric reference frames. In Experiment 1, it was found that body orientation did not affect the magnitude of the up-down exaggeration of direction, suggesting that the relevant orientation reference frame for this directional bias is allocentric rather than egocentric. In Experiment 2, the comparison of large-scale horizontal and vertical extents was somewhat affected by viewer orientation, but only to the extent necessitated by the classic (5%) horizontal-vertical illusion (HVI) that is known to be retinotopic. Large-scale vertical extents continued to appear much larger than horizontal ground extents when observers lay sideways. When the visual world was reoriented in Experiment 3, the bias remained tied to the ground-based allocentric reference frame. The allocentric HVI is quantitatively consistent with differential angular exaggerations previously measured for elevation and azimuth in locomotor space. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  8. Large perceptual distortions of locomotor action space occur in ground-based coordinates: Angular expansion and the large-scale horizontal-vertical illusion

    PubMed Central

    Klein, Brennan J.; Li, Zhi; Durgin, Frank H.

    2015-01-01

    What is the natural reference frame for seeing large-scale spatial scenes in locomotor action space? Prior studies indicate an asymmetric angular expansion in perceived direction in large-scale environments: Angular elevation relative to the horizon is perceptually exaggerated by a factor of 1.5, whereas azimuthal direction is exaggerated by a factor of about 1.25. Here participants made angular and spatial judgments when upright or on their sides in order to dissociate egocentric from allocentric reference frames. In Experiment 1 it was found that body orientation did not affect the magnitude of the up-down exaggeration of direction, suggesting that the relevant orientation reference frame for this directional bias is allocentric rather than egocentric. In Experiment 2, the comparison of large-scale horizontal and vertical extents was somewhat affected by viewer orientation, but only to the extent necessitated by the classic (5%) horizontal-vertical illusion (HVI) that is known to be retinotopic. Large-scale vertical extents continued to appear much larger than horizontal ground extents when observers lay sideways. When the visual world was reoriented in Experiment 3, the bias remained tied to the ground-based allocentric reference frame. The allocentric HVI is quantitatively consistent with differential angular exaggerations previously measured for elevation and azimuth in locomotor space. PMID:26594884

  9. Sparse deconvolution for the large-scale ill-posed inverse problem of impact force reconstruction

    NASA Astrophysics Data System (ADS)

    Qiao, Baijie; Zhang, Xingwu; Gao, Jiawei; Liu, Ruonan; Chen, Xuefeng

    2017-01-01

    Most previous regularization methods for solving the inverse problem of force reconstruction are to minimize the l2-norm of the desired force. However, these traditional regularization methods such as Tikhonov regularization and truncated singular value decomposition, commonly fail to solve the large-scale ill-posed inverse problem in moderate computational cost. In this paper, taking into account the sparse characteristic of impact force, the idea of sparse deconvolution is first introduced to the field of impact force reconstruction and a general sparse deconvolution model of impact force is constructed. Second, a novel impact force reconstruction method based on the primal-dual interior point method (PDIPM) is proposed to solve such a large-scale sparse deconvolution model, where minimizing the l2-norm is replaced by minimizing the l1-norm. Meanwhile, the preconditioned conjugate gradient algorithm is used to compute the search direction of PDIPM with high computational efficiency. Finally, two experiments including the small-scale or medium-scale single impact force reconstruction and the relatively large-scale consecutive impact force reconstruction are conducted on a composite wind turbine blade and a shell structure to illustrate the advantage of PDIPM. Compared with Tikhonov regularization, PDIPM is more efficient, accurate and robust whether in the single impact force reconstruction or in the consecutive impact force reconstruction.

  10. Large Scale Flood Risk Analysis using a New Hyper-resolution Population Dataset

    NASA Astrophysics Data System (ADS)

    Smith, A.; Neal, J. C.; Bates, P. D.; Quinn, N.; Wing, O.

    2017-12-01

    Here we present the first national scale flood risk analyses, using high resolution Facebook Connectivity Lab population data and data from a hyper resolution flood hazard model. In recent years the field of large scale hydraulic modelling has been transformed by new remotely sensed datasets, improved process representation, highly efficient flow algorithms and increases in computational power. These developments have allowed flood risk analysis to be undertaken in previously unmodeled territories and from continental to global scales. Flood risk analyses are typically conducted via the integration of modelled water depths with an exposure dataset. Over large scales and in data poor areas, these exposure data typically take the form of a gridded population dataset, estimating population density using remotely sensed data and/or locally available census data. The local nature of flooding dictates that for robust flood risk analysis to be undertaken both hazard and exposure data should sufficiently resolve local scale features. Global flood frameworks are enabling flood hazard data to produced at 90m resolution, resulting in a mis-match with available population datasets which are typically more coarsely resolved. Moreover, these exposure data are typically focused on urban areas and struggle to represent rural populations. In this study we integrate a new population dataset with a global flood hazard model. The population dataset was produced by the Connectivity Lab at Facebook, providing gridded population data at 5m resolution, representing a resolution increase over previous countrywide data sets of multiple orders of magnitude. Flood risk analysis undertaken over a number of developing countries are presented, along with a comparison of flood risk analyses undertaken using pre-existing population datasets.

  11. Infraslow Electroencephalographic and Dynamic Resting State Network Activity.

    PubMed

    Grooms, Joshua K; Thompson, Garth J; Pan, Wen-Ju; Billings, Jacob; Schumacher, Eric H; Epstein, Charles M; Keilholz, Shella D

    2017-06-01

    A number of studies have linked the blood oxygenation level dependent (BOLD) signal to electroencephalographic (EEG) signals in traditional frequency bands (δ, θ, α, β, and γ), but the relationship between BOLD and its direct frequency correlates in the infraslow band (<1 Hz) has been little studied. Previously, work in rodents showed that infraslow local field potentials play a role in functional connectivity, particularly in the dynamic organization of large-scale networks. To examine the relationship between infraslow activity and network dynamics in humans, direct current (DC) EEG and resting state magnetic resonance imaging data were acquired simultaneously. The DC EEG signals were correlated with the BOLD signal in patterns that resembled resting state networks. Subsequent dynamic analysis showed that the correlation between DC EEG and the BOLD signal varied substantially over time, even within individual subjects. The variation in DC EEG appears to reflect the time-varying contribution of different resting state networks. Furthermore, some of the patterns of DC EEG and BOLD correlation are consistent with previous work demonstrating quasiperiodic spatiotemporal patterns of large-scale network activity in resting state. These findings demonstrate that infraslow electrical activity is linked to BOLD fluctuations in humans and that it may provide a basis for large-scale organization comparable to that observed in animal studies.

  12. Infraslow Electroencephalographic and Dynamic Resting State Network Activity

    PubMed Central

    Grooms, Joshua K.; Thompson, Garth J.; Pan, Wen-Ju; Billings, Jacob; Schumacher, Eric H.; Epstein, Charles M.

    2017-01-01

    Abstract A number of studies have linked the blood oxygenation level dependent (BOLD) signal to electroencephalographic (EEG) signals in traditional frequency bands (δ, θ, α, β, and γ), but the relationship between BOLD and its direct frequency correlates in the infraslow band (<1 Hz) has been little studied. Previously, work in rodents showed that infraslow local field potentials play a role in functional connectivity, particularly in the dynamic organization of large-scale networks. To examine the relationship between infraslow activity and network dynamics in humans, direct current (DC) EEG and resting state magnetic resonance imaging data were acquired simultaneously. The DC EEG signals were correlated with the BOLD signal in patterns that resembled resting state networks. Subsequent dynamic analysis showed that the correlation between DC EEG and the BOLD signal varied substantially over time, even within individual subjects. The variation in DC EEG appears to reflect the time-varying contribution of different resting state networks. Furthermore, some of the patterns of DC EEG and BOLD correlation are consistent with previous work demonstrating quasiperiodic spatiotemporal patterns of large-scale network activity in resting state. These findings demonstrate that infraslow electrical activity is linked to BOLD fluctuations in humans and that it may provide a basis for large-scale organization comparable to that observed in animal studies. PMID:28462586

  13. Demonstration of nanoimprinted hyperlens array for high-throughput sub-diffraction imaging

    NASA Astrophysics Data System (ADS)

    Byun, Minsueop; Lee, Dasol; Kim, Minkyung; Kim, Yangdoo; Kim, Kwan; Ok, Jong G.; Rho, Junsuk; Lee, Heon

    2017-04-01

    Overcoming the resolution limit of conventional optics is regarded as the most important issue in optical imaging science and technology. Although hyperlenses, super-resolution imaging devices based on highly anisotropic dispersion relations that allow the access of high-wavevector components, have recently achieved far-field sub-diffraction imaging in real-time, the previously demonstrated devices have suffered from the extreme difficulties of both the fabrication process and the non-artificial objects placement. This results in restrictions on the practical applications of the hyperlens devices. While implementing large-scale hyperlens arrays in conventional microscopy is desirable to solve such issues, it has not been feasible to fabricate such large-scale hyperlens array with the previously used nanofabrication methods. Here, we suggest a scalable and reliable fabrication process of a large-scale hyperlens device based on direct pattern transfer techniques. We fabricate a 5 cm × 5 cm size hyperlenses array and experimentally demonstrate that it can resolve sub-diffraction features down to 160 nm under 410 nm wavelength visible light. The array-based hyperlens device will provide a simple solution for much more practical far-field and real-time super-resolution imaging which can be widely used in optics, biology, medical science, nanotechnology and other closely related interdisciplinary fields.

  14. Environment and host as large-scale controls of ectomycorrhizal fungi.

    PubMed

    van der Linde, Sietse; Suz, Laura M; Orme, C David L; Cox, Filipa; Andreae, Henning; Asi, Endla; Atkinson, Bonnie; Benham, Sue; Carroll, Christopher; Cools, Nathalie; De Vos, Bruno; Dietrich, Hans-Peter; Eichhorn, Johannes; Gehrmann, Joachim; Grebenc, Tine; Gweon, Hyun S; Hansen, Karin; Jacob, Frank; Kristöfel, Ferdinand; Lech, Paweł; Manninger, Miklós; Martin, Jan; Meesenburg, Henning; Merilä, Päivi; Nicolas, Manuel; Pavlenda, Pavel; Rautio, Pasi; Schaub, Marcus; Schröck, Hans-Werner; Seidling, Walter; Šrámek, Vít; Thimonier, Anne; Thomsen, Iben Margrete; Titeux, Hugues; Vanguelova, Elena; Verstraeten, Arne; Vesterdal, Lars; Waldner, Peter; Wijk, Sture; Zhang, Yuxin; Žlindra, Daniel; Bidartondo, Martin I

    2018-06-06

    Explaining the large-scale diversity of soil organisms that drive biogeochemical processes-and their responses to environmental change-is critical. However, identifying consistent drivers of belowground diversity and abundance for some soil organisms at large spatial scales remains problematic. Here we investigate a major guild, the ectomycorrhizal fungi, across European forests at a spatial scale and resolution that is-to our knowledge-unprecedented, to explore key biotic and abiotic predictors of ectomycorrhizal diversity and to identify dominant responses and thresholds for change across complex environmental gradients. We show the effect of 38 host, environment, climate and geographical variables on ectomycorrhizal diversity, and define thresholds of community change for key variables. We quantify host specificity and reveal plasticity in functional traits involved in soil foraging across gradients. We conclude that environmental and host factors explain most of the variation in ectomycorrhizal diversity, that the environmental thresholds used as major ecosystem assessment tools need adjustment and that the importance of belowground specificity and plasticity has previously been underappreciated.

  15. bigSCale: an analytical framework for big-scale single-cell data.

    PubMed

    Iacono, Giovanni; Mereu, Elisabetta; Guillaumet-Adkins, Amy; Corominas, Roser; Cuscó, Ivon; Rodríguez-Esteban, Gustavo; Gut, Marta; Pérez-Jurado, Luis Alberto; Gut, Ivo; Heyn, Holger

    2018-06-01

    Single-cell RNA sequencing (scRNA-seq) has significantly deepened our insights into complex tissues, with the latest techniques capable of processing tens of thousands of cells simultaneously. Analyzing increasing numbers of cells, however, generates extremely large data sets, extending processing time and challenging computing resources. Current scRNA-seq analysis tools are not designed to interrogate large data sets and often lack sensitivity to identify marker genes. With bigSCale, we provide a scalable analytical framework to analyze millions of cells, which addresses the challenges associated with large data sets. To handle the noise and sparsity of scRNA-seq data, bigSCale uses large sample sizes to estimate an accurate numerical model of noise. The framework further includes modules for differential expression analysis, cell clustering, and marker identification. A directed convolution strategy allows processing of extremely large data sets, while preserving transcript information from individual cells. We evaluated the performance of bigSCale using both a biological model of aberrant gene expression in patient-derived neuronal progenitor cells and simulated data sets, which underlines the speed and accuracy in differential expression analysis. To test its applicability for large data sets, we applied bigSCale to assess 1.3 million cells from the mouse developing forebrain. Its directed down-sampling strategy accumulates information from single cells into index cell transcriptomes, thereby defining cellular clusters with improved resolution. Accordingly, index cell clusters identified rare populations, such as reelin ( Reln )-positive Cajal-Retzius neurons, for which we report previously unrecognized heterogeneity associated with distinct differentiation stages, spatial organization, and cellular function. Together, bigSCale presents a solution to address future challenges of large single-cell data sets. © 2018 Iacono et al.; Published by Cold Spring Harbor Laboratory Press.

  16. Turbulent mass transfer caused by vortex induced reconnection in collisionless magnetospheric plasmas

    DOE PAGES

    Nakamura, T. K. M.; Hasegawa, H.; Daughton, William Scott; ...

    2017-11-17

    Magnetic reconnection is believed to be the main driver to transport solar wind into the Earth’s magnetosphere when the magnetopause features a large magnetic shear. However, even when the magnetic shear is too small for spontaneous reconnection, the Kelvin–Helmholtz instability driven by a super-Alfvénic velocity shear is expected to facilitate the transport. Although previous kinetic simulations have demonstrated that the non-linear vortex flows from the Kelvin–Helmholtz instability gives rise to vortex-induced reconnection and resulting plasma transport, the system sizes of these simulations were too small to allow the reconnection to evolve much beyond the electron scale as recently observed bymore » the Magnetospheric Multiscale (MMS) spacecraft. Here in this paper, based on a large-scale kinetic simulation and its comparison with MMS observations, we show for the first time that ion-scale jets from vortex-induced reconnection rapidly decay through self-generated turbulence, leading to a mass transfer rate nearly one order higher than previous expectations for the Kelvin–Helmholtz instability.« less

  17. Extratropical Respones to Amazon Deforestation

    NASA Astrophysics Data System (ADS)

    Badger, A.; Dirmeyer, P.

    2014-12-01

    Land-use change (LUC) is known to impact local climate conditions through modifications of land-atmosphere interactions. Large-scale LUC, such as Amazon deforestation, could have a significant effect on the local and regional climates. The question remains as to what the global impact of large-scale LUC could be, as previous modeling studies have shown non-local responses due to Amazon deforestation. A common shortcoming in many previous modeling studies is the use of prescribed ocean conditions, which can act as a boundary condition to dampen the global response with respect to changes in the mean and variability. Using fully coupled modeling simulations with the Community Earth System Model version 1.2.0, the Amazon rainforest has been replaced with a distribution of representative tropical crops. Through the modifications of local land-atmosphere interactions, a significant change in the region, both at the surface and throughout the atmosphere, can be quantified. Accompanying these local changes are significant changes to the atmospheric circulation across all scales, thus modifying regional climates in other locales. Notable impacts include significant changes in precipitation, surface fluxes, basin-wide sea surface temperatures and ENSO behavior.

  18. Turbulent mass transfer caused by vortex induced reconnection in collisionless magnetospheric plasmas

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nakamura, T. K. M.; Hasegawa, H.; Daughton, William Scott

    Magnetic reconnection is believed to be the main driver to transport solar wind into the Earth’s magnetosphere when the magnetopause features a large magnetic shear. However, even when the magnetic shear is too small for spontaneous reconnection, the Kelvin–Helmholtz instability driven by a super-Alfvénic velocity shear is expected to facilitate the transport. Although previous kinetic simulations have demonstrated that the non-linear vortex flows from the Kelvin–Helmholtz instability gives rise to vortex-induced reconnection and resulting plasma transport, the system sizes of these simulations were too small to allow the reconnection to evolve much beyond the electron scale as recently observed bymore » the Magnetospheric Multiscale (MMS) spacecraft. Here in this paper, based on a large-scale kinetic simulation and its comparison with MMS observations, we show for the first time that ion-scale jets from vortex-induced reconnection rapidly decay through self-generated turbulence, leading to a mass transfer rate nearly one order higher than previous expectations for the Kelvin–Helmholtz instability.« less

  19. Segmentation of Object Outlines into Parts: A Large-Scale Integrative Study

    ERIC Educational Resources Information Center

    De Winter, Joeri; Wagemans, Johan

    2006-01-01

    In this study, a large number of observers (N=201) were asked to segment a collection of outlines derived from line drawings of everyday objects (N=88). This data set was then used as a benchmark to evaluate current models of object segmentation. All of the previously proposed rules of segmentation were found supported in our results. For example,…

  20. Selfing results in inbreeding depression of growth but not of gas exchange of surviving adult black spruce trees

    Treesearch

    Kurt Johnsen; John E. Major; Chris A. Maier

    2003-01-01

    Summary In most tree species, inbreeding greatly reduces seed production, seed viability, survival and growth. In a previous large-scale quantitative analysis of a black spruce (Picea mariana (Mill.) B.S.P.) diallel experiment, selfing had large deleterious effects on growth but no impact on stable carbon isotope discrimination (an...

  1. Crater size estimates for large-body terrestrial impact

    NASA Technical Reports Server (NTRS)

    Schmidt, Robert M.; Housen, Kevin R.

    1988-01-01

    Calculating the effects of impacts leading to global catastrophes requires knowledge of the impact process at very large size scales. This information cannot be obtained directly but must be inferred from subscale physical simulations, numerical simulations, and scaling laws. Schmidt and Holsapple presented scaling laws based upon laboratory-scale impact experiments performed on a centrifuge (Schmidt, 1980 and Schmidt and Holsapple, 1980). These experiments were used to develop scaling laws which were among the first to include gravity dependence associated with increasing event size. At that time using the results of experiments in dry sand and in water to provide bounds on crater size, they recognized that more precise bounds on large-body impact crater formation could be obtained with additional centrifuge experiments conducted in other geological media. In that previous work, simple power-law formulae were developed to relate final crater diameter to impactor size and velocity. In addition, Schmidt (1980) and Holsapple and Schmidt (1982) recognized that the energy scaling exponent is not a universal constant but depends upon the target media. Recently, Holsapple and Schmidt (1987) includes results for non-porous materials and provides a basis for estimating crater formation kinematics and final crater size. A revised set of scaling relationships for all crater parameters of interest are presented. These include results for various target media and include the kinematics of formation. Particular attention is given to possible limits brought about by very large impactors.

  2. Classification and asymptotic scaling of the light-cone wave-function amplitudes of hadrons

    DOE PAGES

    Ji, Xiangdong; Ma, Jian-Ping; Yuan, Feng

    2004-01-29

    Here we classify the hadron light-cone wave-function amplitudes in terms of parton helicity, orbital angular momentum, and quark-flavor and color symmetries. We show in detail how this is done for the pion, ρ meson, nucleon, and delta resonance up to and including three partons. For the pion and nucleon, we also consider four-parton amplitudes. Using the scaling law derived previously, we show how these amplitudes scale in the limit that all parton transverse momenta become large.

  3. The magnetic shear-current effect: Generation of large-scale magnetic fields by the small-scale dynamo

    DOE PAGES

    Squire, J.; Bhattacharjee, A.

    2016-03-14

    A novel large-scale dynamo mechanism, the magnetic shear-current effect, is discussed and explored. Here, the effect relies on the interaction of magnetic fluctuations with a mean shear flow, meaning the saturated state of the small-scale dynamo can drive a large-scale dynamo – in some sense the inverse of dynamo quenching. The dynamo is non-helical, with the mean fieldmore » $${\\it\\alpha}$$coefficient zero, and is caused by the interaction between an off-diagonal component of the turbulent resistivity and the stretching of the large-scale field by shear flow. Following up on previous numerical and analytic work, this paper presents further details of the numerical evidence for the effect, as well as an heuristic description of how magnetic fluctuations can interact with shear flow to produce the required electromotive force. The pressure response of the fluid is fundamental to this mechanism, which helps explain why the magnetic effect is stronger than its kinematic cousin, and the basic idea is related to the well-known lack of turbulent resistivity quenching by magnetic fluctuations. As well as being interesting for its applications to general high Reynolds number astrophysical turbulence, where strong small-scale magnetic fluctuations are expected to be prevalent, the magnetic shear-current effect is a likely candidate for large-scale dynamo in the unstratified regions of ionized accretion disks. Evidence for this is discussed, as well as future research directions and the challenges involved with understanding details of the effect in astrophysically relevant regimes.« less

  4. Parameterization of plume chemistry into large-scale atmospheric models: Application to aircraft NOx emissions

    NASA Astrophysics Data System (ADS)

    Cariolle, D.; Caro, D.; Paoli, R.; Hauglustaine, D. A.; CuéNot, B.; Cozic, A.; Paugam, R.

    2009-10-01

    A method is presented to parameterize the impact of the nonlinear chemical reactions occurring in the plume generated by concentrated NOx sources into large-scale models. The resulting plume parameterization is implemented into global models and used to evaluate the impact of aircraft emissions on the atmospheric chemistry. Compared to previous approaches that rely on corrected emissions or corrective factors to account for the nonlinear chemical effects, the present parameterization is based on the representation of the plume effects via a fuel tracer and a characteristic lifetime during which the nonlinear interactions between species are important and operate via rates of conversion for the NOx species and an effective reaction rates for O3. The implementation of this parameterization insures mass conservation and allows the transport of emissions at high concentrations in plume form by the model dynamics. Results from the model simulations of the impact on atmospheric ozone of aircraft NOx emissions are in rather good agreement with previous work. It is found that ozone production is decreased by 10 to 25% in the Northern Hemisphere with the largest effects in the north Atlantic flight corridor when the plume effects on the global-scale chemistry are taken into account. These figures are consistent with evaluations made with corrected emissions, but regional differences are noticeable owing to the possibility offered by this parameterization to transport emitted species in plume form prior to their dilution at large scale. This method could be further improved to make the parameters used by the parameterization function of the local temperature, humidity and turbulence properties diagnosed by the large-scale model. Further extensions of the method can also be considered to account for multistep dilution regimes during the plume dissipation. Furthermore, the present parameterization can be adapted to other types of point-source NOx emissions that have to be introduced in large-scale models, such as ship exhausts, provided that the plume life cycle, the type of emissions, and the major reactions involved in the nonlinear chemical systems can be determined with sufficient accuracy.

  5. CONSORT to community: translation of an RCT to a large-scale community intervention and learnings from evaluation of the upscaled program.

    PubMed

    Moores, Carly Jane; Miller, Jacqueline; Perry, Rebecca Anne; Chan, Lily Lai Hang; Daniels, Lynne Allison; Vidgen, Helen Anna; Magarey, Anthea Margaret

    2017-11-29

    Translation encompasses the continuum from clinical efficacy to widespread adoption within the healthcare service and ultimately routine clinical practice. The Parenting, Eating and Activity for Child Health (PEACH™) program has previously demonstrated clinical effectiveness in the management of child obesity, and has been recently implemented as a large-scale community intervention in Queensland, Australia. This paper aims to describe the translation of the evaluation framework from a randomised controlled trial (RCT) to large-scale community intervention (PEACH™ QLD). Tensions between RCT paradigm and implementation research will be discussed along with lived evaluation challenges, responses to overcome these, and key learnings for future evaluation conducted at scale. The translation of evaluation from PEACH™ RCT to the large-scale community intervention PEACH™ QLD is described. While the CONSORT Statement was used to report findings from two previous RCTs, the REAIM framework was more suitable for the evaluation of upscaled delivery of the PEACH™ program. Evaluation of PEACH™ QLD was undertaken during the project delivery period from 2013 to 2016. Experiential learnings from conducting the evaluation of PEACH™ QLD to the described evaluation framework are presented for the purposes of informing the future evaluation of upscaled programs. Evaluation changes in response to real-time changes in the delivery of the PEACH™ QLD Project were necessary at stages during the project term. Key evaluation challenges encountered included the collection of complete evaluation data from a diverse and geographically dispersed workforce and the systematic collection of process evaluation data in real time to support program changes during the project. Evaluation of large-scale community interventions in the real world is challenging and divergent from RCTs which are rigourously evaluated within a more tightly-controlled clinical research setting. Constructs explored in an RCT are inadequate in describing the enablers and barriers of upscaled community program implementation. Methods for data collection, analysis and reporting also require consideration. We present a number of experiential reflections and suggestions for the successful evaluation of future upscaled community programs which are scarcely reported in the literature. PEACH™ QLD was retrospectively registered with the Australian New Zealand Clinical Trials Registry on 28 February 2017 (ACTRN12617000315314).

  6. Hydrologic effects of large southwestern USA wildfires significantly increase regional water supply: fact or fiction?

    NASA Astrophysics Data System (ADS)

    Wine, M. L.; Cadol, D.

    2016-08-01

    In recent years climate change and historic fire suppression have increased the frequency of large wildfires in the southwestern USA, motivating study of the hydrological consequences of these wildfires at point and watershed scales, typically over short periods of time. These studies have revealed that reduced soil infiltration capacity and reduced transpiration due to tree canopy combustion increase streamflow at the watershed scale. However, the degree to which these local increases in runoff propagate to larger scales—relevant to urban and agricultural water supply—remains largely unknown, particularly in semi-arid mountainous watersheds co-dominated by winter snowmelt and the North American monsoon. To address this question, we selected three New Mexico watersheds—the Jemez (1223 km2), Mogollon (191 km2), and Gila (4807 km2)—that together have been affected by over 100 wildfires since 1982. We then applied climate-driven linear models to test for effects of fire on streamflow metrics after controlling for climatic variability. Here we show that, after controlling for climatic and snowpack variability, significantly more streamflow discharged from the Gila watershed for three to five years following wildfires, consistent with increased regional water yield due to enhanced infiltration-excess overland flow and groundwater recharge at the large watershed scale. In contrast, we observed no such increase in discharge from the Jemez watershed following wildfires. Fire regimes represent a key difference between the contrasting responses of the Jemez and Gila watersheds with the latter experiencing more frequent wildfires, many caused by lightning strikes. While hydrologic dynamics at the scale of large watersheds were previously thought to be climatically dominated, these results suggest that if one fifth or more of a large watershed has been burned in the previous three to five years, significant increases in water yield can be expected.

  7. Channel optimization of high-intensity laser beams in millimeter-scale plasmas

    DOE PAGES

    Ceurvorst, L.; Savin, A.; Ratan, N.; ...

    2018-04-20

    Channeling experiments were performed at the OMEGA EP facility using relativistic intensity (> 10 18 W/cm 2) kilojoule laser pulses through large density scale length (~ 390-570 μm) laser-produced plasmas, demonstrating the effects of the pulse’s focal location and intensity as well as the plasma’s temperature on the resulting channel formation. The results show deeper channeling when focused into hot plasmas and at lower densities as expected. However, contrary to previous large scale particle-in-cell studies, the results also indicate deeper penetration by short (10 ps), intense pulses compared to their longer duration equivalents. To conclude, this new observation has manymore » implications for future laser-plasma research in the relativistic regime.« less

  8. Large-scale structure from cosmic-string loops in a baryon-dominated universe

    NASA Technical Reports Server (NTRS)

    Melott, Adrian L.; Scherrer, Robert J.

    1988-01-01

    The results are presented of a numerical simulation of the formation of large-scale structure in a universe with Omega(0) = 0.2 and h = 0.5 dominated by baryons in which cosmic strings provide the initial density perturbations. The numerical model yields a power spectrum. Nonlinear evolution confirms that the model can account for 700 km/s bulk flows and a strong cluster-cluster correlation, but does rather poorly on smaller scales. There is no visual 'filamentary' structure, and the two-point correlation has too steep a logarithmic slope. The value of G mu = 4 x 10 to the -6th is significantly lower than previous estimates for the value of G mu in baryon-dominated cosmic string models.

  9. Channel optimization of high-intensity laser beams in millimeter-scale plasmas

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ceurvorst, L.; Savin, A.; Ratan, N.

    Channeling experiments were performed at the OMEGA EP facility using relativistic intensity (> 10 18 W/cm 2) kilojoule laser pulses through large density scale length (~ 390-570 μm) laser-produced plasmas, demonstrating the effects of the pulse’s focal location and intensity as well as the plasma’s temperature on the resulting channel formation. The results show deeper channeling when focused into hot plasmas and at lower densities as expected. However, contrary to previous large scale particle-in-cell studies, the results also indicate deeper penetration by short (10 ps), intense pulses compared to their longer duration equivalents. To conclude, this new observation has manymore » implications for future laser-plasma research in the relativistic regime.« less

  10. Demand surge following earthquakes

    USGS Publications Warehouse

    Olsen, Anna H.

    2012-01-01

    Demand surge is understood to be a socio-economic phenomenon where repair costs for the same damage are higher after large- versus small-scale natural disasters. It has reportedly increased monetary losses by 20 to 50%. In previous work, a model for the increased costs of reconstruction labor and materials was developed for hurricanes in the Southeast United States. The model showed that labor cost increases, rather than the material component, drove the total repair cost increases, and this finding could be extended to earthquakes. A study of past large-scale disasters suggested that there may be additional explanations for demand surge. Two such explanations specific to earthquakes are the exclusion of insurance coverage for earthquake damage and possible concurrent causation of damage from an earthquake followed by fire or tsunami. Additional research into these aspects might provide a better explanation for increased monetary losses after large- vs. small-scale earthquakes.

  11. Evidence for Large Decadal Variability in the Tropical Mean Radiative Energy Budget

    NASA Technical Reports Server (NTRS)

    Wielicki, Bruce A.; Wong, Takmeng; Allan, Richard; Slingo, Anthony; Kiehl, Jeffrey T.; Soden, Brian J.; Gordon, C. T.; Miller, Alvin J.; Yang, Shi-Keng; Randall, David R.; hide

    2001-01-01

    It is widely assumed that variations in the radiative energy budget at large time and space scales are very small. We present new evidence from a compilation of over two decades of accurate satellite data that the top-of-atmosphere (TOA) tropical radiative energy budget is much more dynamic and variable than previously thought. We demonstrate that the radiation budget changes are caused by changes In tropical mean cloudiness. The results of several current climate model simulations fall to predict this large observed variation In tropical energy budget. The missing variability in the models highlights the critical need to Improve cloud modeling in the tropics to support Improved prediction of tropical climate on Inter-annual and decadal time scales. We believe that these data are the first rigorous demonstration of decadal time scale changes In the Earth's tropical cloudiness, and that they represent a new and necessary test of climate models.

  12. Water, Carbon, and Nutrient Cycling Following Insect-induced Tree Mortality: How Well Do Plot-scale Observations Predict Ecosystem-Scale Response?

    NASA Astrophysics Data System (ADS)

    Brooks, P. D.; Barnard, H. R.; Biederman, J. A.; Borkhuu, B.; Edburg, S. L.; Ewers, B. E.; Gochis, D. J.; Gutmann, E. D.; Harpold, A. A.; Hicke, J. A.; Pendall, E.; Reed, D. E.; Somor, A. J.; Troch, P. A.

    2011-12-01

    Widespread tree mortality caused by insect infestations and drought has impacted millions of hectares across western North America in recent years. Although previous work on post-disturbance responses (e.g. experimental manipulations, fire, and logging) provides insight into how water and biogeochemical cycles may respond to insect infestations and drought, we find that the unique nature of these drivers of tree mortality complicates extrapolation to larger scales. Building from previous work on forest disturbance, we present a conceptual model of how temporal changes in forest structure impact the individual components of energy balance, hydrologic partitioning, and biogeochemical cycling and the interactions among them. We evaluate and refine this model using integrated observations and process modeling on multiple scales including plot, stand, flux tower footprint, hillslope, and catchment to identify scaling relationships and emergent patterns in hydrological and biogeochemical responses. Our initial results suggest that changes in forest structure at point or plot scales largely have predictable effects on energy, water, and biogeochemical cycles that are well captured by land surface, hydrological, and biogeochemical models. However, observations from flux towers and nested catchments suggest that both the hydrological and biogeochemical effects observed at tree and plot scales may be attenuated or exacerbated at larger scales. Compensatory processes are associated with attenuation (e.g. as transpiration decreases, evaporation and sublimation increase), whereas both attenuation and exacerbation may result from nonlinear scaling behavior across transitions in topography and ecosystem structure that affect the redistribution of energy, water, and solutes. Consequently, the effects of widespread tree mortality on ecosystem services of water supply and carbon sequestration will likely depend on how spatial patterns in mortality severity across the landscape affect large-scale hydrological partitioning.

  13. Large-scale preparation of clove essential oil and eugenol-loaded liposomes using a membrane contactor and a pilot plant.

    PubMed

    Sebaaly, Carine; Greige-Gerges, Hélène; Agusti, Géraldine; Fessi, Hatem; Charcosset, Catherine

    2016-01-01

    Based on our previous study where optimal conditions were defined to encapsulate clove essential oil (CEO) into liposomes at laboratory scale, we scaled-up the preparation of CEO and eugenol (Eug)-loaded liposomes using a membrane contactor (600 mL) and a pilot plant (3 L) based on the principle of ethanol injection method, both equipped with a Shirasu Porous Glass membrane for injection of the organic phase into the aqueous phase. Homogenous, stable, nanometric-sized and multilamellar liposomes with high phospholipid, Eug loading rates and encapsulation efficiency of CEO components were obtained. Saturation of phospholipids and drug concentration in the organic phase may control the liposome stability. Liposomes loaded with other hydrophobic volatile compounds could be prepared at large scale using the ethanol injection method and a membrane for injection.

  14. The Gould's Belt very large array survey. III. The Orion region

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kounkel, Marina; Hartmann, Lee; Loinard, Laurent

    2014-07-20

    We present results from a high-sensitivity (60 μJy), large-scale (2.26 deg{sup 2}) survey obtained with the Karl G. Jansky Very Large Array as part of the Gould's Belt Survey program. We detected 374 and 354 sources at 4.5 and 7.5 GHz, respectively. Of these, 148 are associated with previously known young stellar objects (YSOs). Another 86 sources previously unclassified at either optical or infrared wavelengths exhibit radio properties that are consistent with those of young stars. The overall properties of our sources at radio wavelengths such as their variability and radio to X-ray luminosity relation are consistent with previous resultsmore » from the Gould's Belt Survey. Our detections provide target lists for follow-up Very Long Baseline Array radio observations to determine their distances as YSOs are located in regions of high nebulosity and extinction, making it difficult to measure optical parallaxes.« less

  15. The Gould's Belt Very Large Array Survey. III. The Orion Region

    NASA Astrophysics Data System (ADS)

    Kounkel, Marina; Hartmann, Lee; Loinard, Laurent; Mioduszewski, Amy J.; Dzib, Sergio A.; Ortiz-León, Gisela N.; Rodríguez, Luis F.; Pech, Gerardo; Rivera, Juana L.; Torres, Rosa M.; Boden, Andrew F.; Evans, Neal J., II; Briceño, Cesar; Tobin, John

    2014-07-01

    We present results from a high-sensitivity (60 μJy), large-scale (2.26 deg2) survey obtained with the Karl G. Jansky Very Large Array as part of the Gould's Belt Survey program. We detected 374 and 354 sources at 4.5 and 7.5 GHz, respectively. Of these, 148 are associated with previously known young stellar objects (YSOs). Another 86 sources previously unclassified at either optical or infrared wavelengths exhibit radio properties that are consistent with those of young stars. The overall properties of our sources at radio wavelengths such as their variability and radio to X-ray luminosity relation are consistent with previous results from the Gould's Belt Survey. Our detections provide target lists for follow-up Very Long Baseline Array radio observations to determine their distances as YSOs are located in regions of high nebulosity and extinction, making it difficult to measure optical parallaxes.

  16. Southern Argentina Agile Meteor Radar: System design and initial measurements of large-scale winds and tides

    NASA Astrophysics Data System (ADS)

    Fritts, D. C.; Janches, D.; Iimura, H.; Hocking, W. K.; Mitchell, N. J.; Stockwell, R. G.; Fuller, B.; Vandepeer, B.; Hormaechea, J.; Brunini, C.; Levato, H.

    2010-09-01

    The Southern Argentina Agile Meteor Radar (SAAMER) was installed at Rio Grande on Tierra del Fuego (53.8°S, 67.8°W) in May 2008 and has been operational for ˜24 months. This paper describes the motivations for the radar design and its placement at the southern tip of South America, its operating modes and capabilities, and observations of the mean winds, planetary waves, and tides during its first ˜20 months of operation. SAAMER was specifically designed to provide very high resolution of large-scale motions and hopefully enable direct measurements of the vertical momentum flux by gravity waves, which have only been possible previously with dual- or multiple-beam radars and lidars or in situ measurements. SAAMER was placed on Tierra del Fuego because it was a region devoid of similar measurements, the latitude was anticipated to provide high sensitivity to an expected large semidiurnal tide, and the region is now recognized to be a "hot spot" of small-scale gravity wave activity extending from the troposphere into the mesosphere and lower thermosphere, perhaps the most dynamically active location on Earth. SAAMER was also intended to permit simultaneous enhanced meteor studies, including "head echo" and "nonspecular" measurements, which were previously possible only with high-power large-aperture radars. Initial measurements have defined the mean circulation and structure, exhibited planetary waves at various periods, and revealed large semidiurnal tide amplitudes and variability, with maximum amplitudes at higher altitudes often exceeding 60 m s-1 and amplitude modulations at periods from a few to ˜30 days.

  17. Modal interactions between a large-wavelength inclined interface and small-wavelength multimode perturbations in a Richtmyer-Meshkov instability

    NASA Astrophysics Data System (ADS)

    McFarland, Jacob A.; Reilly, David; Black, Wolfgang; Greenough, Jeffrey A.; Ranjan, Devesh

    2015-07-01

    The interaction of a small-wavelength multimodal perturbation with a large-wavelength inclined interface perturbation is investigated for the reshocked Richtmyer-Meshkov instability using three-dimensional simulations. The ares code, developed at Lawrence Livermore National Laboratory, was used for these simulations and a detailed comparison of simulation results and experiments performed at the Georgia Tech Shock Tube facility is presented first for code validation. Simulation results are presented for four cases that vary in large-wavelength perturbation amplitude and the presence of secondary small-wavelength multimode perturbations. Previously developed measures of mixing and turbulence quantities are presented that highlight the large variation in perturbation length scales created by the inclined interface and the multimode complex perturbation. Measures are developed for entrainment, and turbulence anisotropy that help to identify the effects of and competition between each perturbations type. It is shown through multiple measures that before reshock the flow processes a distinct memory of the initial conditions that is present in both large-scale-driven entrainment measures and small-scale-driven mixing measures. After reshock the flow develops to a turbulentlike state that retains a memory of high-amplitude but not low-amplitude large-wavelength perturbations. It is also shown that the high-amplitude large-wavelength perturbation is capable of producing small-scale mixing and turbulent features similar to the small-wavelength multimode perturbations.

  18. Parallel Large-Scale Molecular Dynamics Simulation Opens New Perspective to Clarify the Effect of a Porous Structure on the Sintering Process of Ni/YSZ Multiparticles.

    PubMed

    Xu, Jingxiang; Higuchi, Yuji; Ozawa, Nobuki; Sato, Kazuhisa; Hashida, Toshiyuki; Kubo, Momoji

    2017-09-20

    Ni sintering in the Ni/YSZ porous anode of a solid oxide fuel cell changes the porous structure, leading to degradation. Preventing sintering and degradation during operation is a great challenge. Usually, a sintering molecular dynamics (MD) simulation model consisting of two particles on a substrate is used; however, the model cannot reflect the porous structure effect on sintering. In our previous study, a multi-nanoparticle sintering modeling method with tens of thousands of atoms revealed the effect of the particle framework and porosity on sintering. However, the method cannot reveal the effect of the particle size on sintering and the effect of sintering on the change in the porous structure. In the present study, we report a strategy to reveal them in the porous structure by using our multi-nanoparticle modeling method and a parallel large-scale multimillion-atom MD simulator. We used this method to investigate the effect of YSZ particle size and tortuosity on sintering and degradation in the Ni/YSZ anodes. Our parallel large-scale MD simulation showed that the sintering degree decreased as the YSZ particle size decreased. The gas fuel diffusion path, which reflects the overpotential, was blocked by pore coalescence during sintering. The degradation of gas diffusion performance increased as the YSZ particle size increased. Furthermore, the gas diffusion performance was quantified by a tortuosity parameter and an optimal YSZ particle size, which is equal to that of Ni, was found for good diffusion after sintering. These findings cannot be obtained by previous MD sintering studies with tens of thousands of atoms. The present parallel large-scale multimillion-atom MD simulation makes it possible to clarify the effects of the particle size and tortuosity on sintering and degradation.

  19. THE EFFECT OF INTERMITTENT GYRO-SCALE SLAB TURBULENCE ON PARALLEL AND PERPENDICULAR COSMIC-RAY TRANSPORT

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Le Roux, J. A.

    Earlier work based on nonlinear guiding center (NLGC) theory suggested that perpendicular cosmic-ray transport is diffusive when cosmic rays encounter random three-dimensional magnetohydrodynamic turbulence dominated by uniform two-dimensional (2D) turbulence with a minor uniform slab turbulence component. In this approach large-scale perpendicular cosmic-ray transport is due to cosmic rays microscopically diffusing along the meandering magnetic field dominated by 2D turbulence because of gyroresonant interactions with slab turbulence. However, turbulence in the solar wind is intermittent and it has been suggested that intermittent turbulence might be responsible for the observation of 'dropout' events in solar energetic particle fluxes on small scales.more » In a previous paper le Roux et al. suggested, using NLGC theory as a basis, that if gyro-scale slab turbulence is intermittent, large-scale perpendicular cosmic-ray transport in weak uniform 2D turbulence will be superdiffusive or subdiffusive depending on the statistical characteristics of the intermittent slab turbulence. In this paper we expand and refine our previous work further by investigating how both parallel and perpendicular transport are affected by intermittent slab turbulence for weak as well as strong uniform 2D turbulence. The main new finding is that both parallel and perpendicular transport are the net effect of an interplay between diffusive and nondiffusive (superdiffusive or subdiffusive) transport effects as a consequence of this intermittency.« less

  20. Efficient and Extensible Quasi-Explicit Modular Nonlinear Multiscale Battery Model: GH-MSMD

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kim, Gi-Heon; Smith, Kandler; Lawrence-Simon, Jake

    Complex physics and long computation time hinder the adoption of computer aided engineering models in the design of large-format battery cells and systems. A modular, efficient battery simulation model -- the multiscale multidomain (MSMD) model -- was previously introduced to aid the scale-up of Li-ion material and electrode designs to complete cell and pack designs, capturing electrochemical interplay with 3-D electronic current pathways and thermal response. Here, this paper enhances the computational efficiency of the MSMD model using a separation of time-scales principle to decompose model field variables. The decomposition provides a quasi-explicit linkage between the multiple length-scale domains andmore » thus reduces time-consuming nested iteration when solving model equations across multiple domains. In addition to particle-, electrode- and cell-length scales treated in the previous work, the present formulation extends to bus bar- and multi-cell module-length scales. We provide example simulations for several variants of GH electrode-domain models.« less

  1. Efficient and Extensible Quasi-Explicit Modular Nonlinear Multiscale Battery Model: GH-MSMD

    DOE PAGES

    Kim, Gi-Heon; Smith, Kandler; Lawrence-Simon, Jake; ...

    2017-03-24

    Complex physics and long computation time hinder the adoption of computer aided engineering models in the design of large-format battery cells and systems. A modular, efficient battery simulation model -- the multiscale multidomain (MSMD) model -- was previously introduced to aid the scale-up of Li-ion material and electrode designs to complete cell and pack designs, capturing electrochemical interplay with 3-D electronic current pathways and thermal response. Here, this paper enhances the computational efficiency of the MSMD model using a separation of time-scales principle to decompose model field variables. The decomposition provides a quasi-explicit linkage between the multiple length-scale domains andmore » thus reduces time-consuming nested iteration when solving model equations across multiple domains. In addition to particle-, electrode- and cell-length scales treated in the previous work, the present formulation extends to bus bar- and multi-cell module-length scales. We provide example simulations for several variants of GH electrode-domain models.« less

  2. High flexibility of DNA on short length scales probed by atomic force microscopy.

    PubMed

    Wiggins, Paul A; van der Heijden, Thijn; Moreno-Herrero, Fernando; Spakowitz, Andrew; Phillips, Rob; Widom, Jonathan; Dekker, Cees; Nelson, Philip C

    2006-11-01

    The mechanics of DNA bending on intermediate length scales (5-100 nm) plays a key role in many cellular processes, and is also important in the fabrication of artificial DNA structures, but previous experimental studies of DNA mechanics have focused on longer length scales than these. We use high-resolution atomic force microscopy on individual DNA molecules to obtain a direct measurement of the bending energy function appropriate for scales down to 5 nm. Our measurements imply that the elastic energy of highly bent DNA conformations is lower than predicted by classical elasticity models such as the worm-like chain (WLC) model. For example, we found that on short length scales, spontaneous large-angle bends are many times more prevalent than predicted by the WLC model. We test our data and model with an interlocking set of consistency checks. Our analysis also shows how our model is compatible with previous experiments, which have sometimes been viewed as confirming the WLC.

  3. Polygamy and an absence of fine-scale structure in Dendroctonus ponderosae (Hopk.) (Coleoptera: Curcilionidae) confirmed using molecular markers

    PubMed Central

    Janes, J K; Roe, A D; Rice, A V; Gorrell, J C; Coltman, D W; Langor, D W; Sperling, F A H

    2016-01-01

    An understanding of mating systems and fine-scale spatial genetic structure is required to effectively manage forest pest species such as Dendroctonus ponderosae (mountain pine beetle). Here we used genome-wide single-nucleotide polymorphisms to assess the fine-scale genetic structure and mating system of D. ponderosae collected from a single stand in Alberta, Canada. Fine-scale spatial genetic structure was absent within the stand and the majority of genetic variation was best explained at the individual level. Relatedness estimates support previous reports of pre-emergence mating. Parentage assignment tests indicate that a polygamous mating system better explains the relationships among individuals within a gallery than the previously reported female monogamous/male polygynous system. Furthermore, there is some evidence to suggest that females may exploit the galleries of other females, at least under epidemic conditions. Our results suggest that current management models are likely to be effective across large geographic areas based on the absence of fine-scale genetic structure. PMID:26286666

  4. Climate, Water, and Human Health: Large Scale Hydroclimatic Controls in Forecasting Cholera Epidemics

    NASA Astrophysics Data System (ADS)

    Akanda, A. S.; Jutla, A. S.; Islam, S.

    2009-12-01

    Despite ravaging the continents through seven global pandemics in past centuries, the seasonal and interannual variability of cholera outbreaks remain a mystery. Previous studies have focused on the role of various environmental and climatic factors, but provided little or no predictive capability. Recent findings suggest a more prominent role of large scale hydroclimatic extremes - droughts and floods - and attempt to explain the seasonality and the unique dual cholera peaks in the Bengal Delta region of South Asia. We investigate the seasonal and interannual nature of cholera epidemiology in three geographically distinct locations within the region to identify the larger scale hydroclimatic controls that can set the ecological and environmental ‘stage’ for outbreaks and have significant memory on a seasonal scale. Here we show that two distinctly different, pre and post monsoon, cholera transmission mechanisms related to large scale climatic controls prevail in the region. An implication of our findings is that extreme climatic events such as prolonged droughts, record floods, and major cyclones may cause major disruption in the ecosystem and trigger large epidemics. We postulate that a quantitative understanding of the large-scale hydroclimatic controls and dominant processes with significant system memory will form the basis for forecasting such epidemic outbreaks. A multivariate regression method using these predictor variables to develop probabilistic forecasts of cholera outbreaks will be explored. Forecasts from such a system with a seasonal lead-time are likely to have measurable impact on early cholera detection and prevention efforts in endemic regions.

  5. Sensitivity of tree ring growth to local and large-scale climate variability in a region of Southeastern Brazil

    NASA Astrophysics Data System (ADS)

    Venegas-González, Alejandro; Chagas, Matheus Peres; Anholetto Júnior, Claudio Roberto; Alvares, Clayton Alcarde; Roig, Fidel Alejandro; Tomazello Filho, Mario

    2016-01-01

    We explored the relationship between tree growth in two tropical species and local and large-scale climate variability in Southeastern Brazil. Tree ring width chronologies of Tectona grandis (teak) and Pinus caribaea (Caribbean pine) trees were compared with local (Water Requirement Satisfaction Index—WRSI, Standardized Precipitation Index—SPI, and Palmer Drought Severity Index—PDSI) and large-scale climate indices that analyze the equatorial pacific sea surface temperature (Trans-Niño Index-TNI and Niño-3.4-N3.4) and atmospheric circulation variations in the Southern Hemisphere (Antarctic Oscillation-AAO). Teak trees showed positive correlation with three indices in the current summer and fall. A significant correlation between WRSI index and Caribbean pine was observed in the dry season preceding tree ring formation. The influence of large-scale climate patterns was observed only for TNI and AAO, where there was a radial growth reduction in months preceding the growing season with positive values of the TNI in teak trees and radial growth increase (decrease) during December (March) to February (May) of the previous (current) growing season with positive phase of the AAO in teak (Caribbean pine) trees. The development of a new dendroclimatological study in Southeastern Brazil sheds light to local and large-scale climate influence on tree growth in recent decades, contributing in future climate change studies.

  6. Replication of a Test-Retest Factorial Validity Study with the Piers-Harris Children's Self Concept Scale.

    ERIC Educational Resources Information Center

    Platten, Marvin R.; Williams, Larry R.

    1981-01-01

    This study largely replicates the findings of a previous study reported by the authors. Further research involving the physical dimension as a possible facet of general self-concept is suggested. (Author/BW)

  7. Micron-scale lens array having diffracting structures

    DOEpatents

    Goldberg, Kenneth A

    2013-10-29

    A novel micron-scale lens, a microlens, is engineered to concentrate light efficiently onto an area of interest, such as a small, light-sensitive detector element in an integrated electronic device. Existing microlens designs imitate the form of large-scale lenses and are less effective at small sizes. The microlenses described herein have been designed to accommodate diffraction effects, which dominate the behavior of light at small length scales. Thus a new class of light-concentrating optical elements with much higher relative performance has been created. Furthermore, the new designs are much easier to fabricate than previous designs.

  8. Ribbons characterize magnetohydrodynamic magnetic fields better than lines: a lesson from dynamo theory

    NASA Astrophysics Data System (ADS)

    Blackman, Eric G.; Hubbard, Alexander

    2014-08-01

    Blackman and Brandenburg argued that magnetic helicity conservation in dynamo theory can in principle be captured by diagrams of mean field dynamos when the magnetic fields are represented by ribbons or tubes, but not by lines. Here, we present such a schematic ribbon diagram for the α2 dynamo that tracks magnetic helicity and provides distinct scales of large-scale magnetic helicity, small-scale magnetic helicity, and kinetic helicity involved in the process. This also motivates our construction of a new `2.5 scale' minimalist generalization of the helicity-evolving equations for the α2 dynamo that separately allows for these three distinct length-scales while keeping only two dynamical equations. We solve these equations and, as in previous studies, find that the large-scale field first grows at a rate independent of the magnetic Reynolds number RM before quenching to an RM-dependent regime. But we also show that the larger the ratio of the wavenumber where the small-scale current helicity resides to that of the forcing scale, the earlier the non-linear dynamo quenching occurs, and the weaker the large-scale field is at the turnoff from linear growth. The harmony between the theory and the schematic diagram exemplifies a general lesson that magnetic fields in magnetohydrodynamic are better visualized as two-dimensional ribbons (or pairs of lines) rather than single lines.

  9. Modelling high Reynolds number wall–turbulence interactions in laboratory experiments using large-scale free-stream turbulence

    PubMed Central

    Dogan, Eda; Hearst, R. Jason

    2017-01-01

    A turbulent boundary layer subjected to free-stream turbulence is investigated in order to ascertain the scale interactions that dominate the near-wall region. The results are discussed in relation to a canonical high Reynolds number turbulent boundary layer because previous studies have reported considerable similarities between these two flows. Measurements were acquired simultaneously from four hot wires mounted to a rake which was traversed through the boundary layer. Particular focus is given to two main features of both canonical high Reynolds number boundary layers and boundary layers subjected to free-stream turbulence: (i) the footprint of the large scales in the logarithmic region on the near-wall small scales, specifically the modulating interaction between these scales, and (ii) the phase difference in amplitude modulation. The potential for a turbulent boundary layer subjected to free-stream turbulence to ‘simulate’ high Reynolds number wall–turbulence interactions is discussed. The results of this study have encouraging implications for future investigations of the fundamental scale interactions that take place in high Reynolds number flows as it demonstrates that these can be achieved at typical laboratory scales. This article is part of the themed issue ‘Toward the development of high-fidelity models of wall turbulence at large Reynolds number’. PMID:28167584

  10. Modelling high Reynolds number wall-turbulence interactions in laboratory experiments using large-scale free-stream turbulence.

    PubMed

    Dogan, Eda; Hearst, R Jason; Ganapathisubramani, Bharathram

    2017-03-13

    A turbulent boundary layer subjected to free-stream turbulence is investigated in order to ascertain the scale interactions that dominate the near-wall region. The results are discussed in relation to a canonical high Reynolds number turbulent boundary layer because previous studies have reported considerable similarities between these two flows. Measurements were acquired simultaneously from four hot wires mounted to a rake which was traversed through the boundary layer. Particular focus is given to two main features of both canonical high Reynolds number boundary layers and boundary layers subjected to free-stream turbulence: (i) the footprint of the large scales in the logarithmic region on the near-wall small scales, specifically the modulating interaction between these scales, and (ii) the phase difference in amplitude modulation. The potential for a turbulent boundary layer subjected to free-stream turbulence to 'simulate' high Reynolds number wall-turbulence interactions is discussed. The results of this study have encouraging implications for future investigations of the fundamental scale interactions that take place in high Reynolds number flows as it demonstrates that these can be achieved at typical laboratory scales.This article is part of the themed issue 'Toward the development of high-fidelity models of wall turbulence at large Reynolds number'. © 2017 The Author(s).

  11. Large Eddy Simulation Study for Fluid Disintegration and Mixing

    NASA Technical Reports Server (NTRS)

    Bellan, Josette; Taskinoglu, Ezgi

    2011-01-01

    A new modeling approach is based on the concept of large eddy simulation (LES) within which the large scales are computed and the small scales are modeled. The new approach is expected to retain the fidelity of the physics while also being computationally efficient. Typically, only models for the small-scale fluxes of momentum, species, and enthalpy are used to reintroduce in the simulation the physics lost because the computation only resolves the large scales. These models are called subgrid (SGS) models because they operate at a scale smaller than the LES grid. In a previous study of thermodynamically supercritical fluid disintegration and mixing, additional small-scale terms, one in the momentum and one in the energy conservation equations, were identified as requiring modeling. These additional terms were due to the tight coupling between dynamics and real-gas thermodynamics. It was inferred that if these terms would not be modeled, the high density-gradient magnitude regions, experimentally identified as a characteristic feature of these flows, would not be accurately predicted without the additional term in the momentum equation; these high density-gradient magnitude regions were experimentally shown to redistribute turbulence in the flow. And it was also inferred that without the additional term in the energy equation, the heat flux magnitude could not be accurately predicted; the heat flux to the wall of combustion devices is a crucial quantity that determined necessary wall material properties. The present work involves situations where only the term in the momentum equation is important. Without this additional term in the momentum equation, neither the SGS-flux constant-coefficient Smagorinsky model nor the SGS-flux constant-coefficient Gradient model could reproduce in LES the pressure field or the high density-gradient magnitude regions; the SGS-flux constant- coefficient Scale-Similarity model was the most successful in this endeavor although not totally satisfactory. With a model for the additional term in the momentum equation, the predictions of the constant-coefficient Smagorinsky and constant-coefficient Scale-Similarity models were improved to a certain extent; however, most of the improvement was obtained for the Gradient model. The previously derived model and a newly developed model for the additional term in the momentum equation were both tested, with the new model proving even more successful than the previous model at reproducing the high density-gradient magnitude regions. Several dynamic SGS-flux models, in which the SGS-flux model coefficient is computed as part of the simulation, were tested in conjunction with the new model for this additional term in the momentum equation. The most successful dynamic model was a "mixed" model combining the Smagorinsky and Gradient models. This work is directly applicable to simulations of gas turbine engines (aeronautics) and rocket engines (astronautics).

  12. A Lagrangian subgrid-scale model with dynamic estimation of Lagrangian time scale for large eddy simulation of complex flows

    NASA Astrophysics Data System (ADS)

    Verma, Aman; Mahesh, Krishnan

    2012-08-01

    The dynamic Lagrangian averaging approach for the dynamic Smagorinsky model for large eddy simulation is extended to an unstructured grid framework and applied to complex flows. The Lagrangian time scale is dynamically computed from the solution and does not need any adjustable parameter. The time scale used in the standard Lagrangian model contains an adjustable parameter θ. The dynamic time scale is computed based on a "surrogate-correlation" of the Germano-identity error (GIE). Also, a simple material derivative relation is used to approximate GIE at different events along a pathline instead of Lagrangian tracking or multi-linear interpolation. Previously, the time scale for homogeneous flows was computed by averaging along directions of homogeneity. The present work proposes modifications for inhomogeneous flows. This development allows the Lagrangian averaged dynamic model to be applied to inhomogeneous flows without any adjustable parameter. The proposed model is applied to LES of turbulent channel flow on unstructured zonal grids at various Reynolds numbers. Improvement is observed when compared to other averaging procedures for the dynamic Smagorinsky model, especially at coarse resolutions. The model is also applied to flow over a cylinder at two Reynolds numbers and good agreement with previous computations and experiments is obtained. Noticeable improvement is obtained using the proposed model over the standard Lagrangian model. The improvement is attributed to a physically consistent Lagrangian time scale. The model also shows good performance when applied to flow past a marine propeller in an off-design condition; it regularizes the eddy viscosity and adjusts locally to the dominant flow features.

  13. Successful scaling-up of self-sustained pyrolysis of oil palm biomass under pool-type reactor.

    PubMed

    Idris, Juferi; Shirai, Yoshihito; Andou, Yoshito; Mohd Ali, Ahmad Amiruddin; Othman, Mohd Ridzuan; Ibrahim, Izzudin; Yamamoto, Akio; Yasuda, Nobuhiko; Hassan, Mohd Ali

    2016-02-01

    An appropriate technology for waste utilisation, especially for a large amount of abundant pressed-shredded oil palm empty fruit bunch (OFEFB), is important for the oil palm industry. Self-sustained pyrolysis, whereby oil palm biomass was combusted by itself to provide the heat for pyrolysis without an electrical heater, is more preferable owing to its simplicity, ease of operation and low energy requirement. In this study, biochar production under self-sustained pyrolysis of oil palm biomass in the form of oil palm empty fruit bunch was tested in a 3-t large-scale pool-type reactor. During the pyrolysis process, the biomass was loaded layer by layer when the smoke appeared on the top, to minimise the entrance of oxygen. This method had significantly increased the yield of biochar. In our previous report, we have tested on a 30-kg pilot-scale capacity under self-sustained pyrolysis and found that the higher heating value (HHV) obtained was 22.6-24.7 MJ kg(-1) with a 23.5%-25.0% yield. In this scaled-up study, a 3-t large-scale procedure produced HHV of 22.0-24.3 MJ kg(-1) with a 30%-34% yield based on a wet-weight basis. The maximum self-sustained pyrolysis temperature for the large-scale procedure can reach between 600 °C and 700 °C. We concluded that large-scale biochar production under self-sustained pyrolysis was successfully conducted owing to the comparable biochar produced, compared with medium-scale and other studies with an electrical heating element, making it an appropriate technology for waste utilisation, particularly for the oil palm industry. © The Author(s) 2015.

  14. “Real-Time” Cosmology with Extragalactic Proper Motions: the Secular Aberration Drift and Evolution of Large-Scale Structure

    NASA Astrophysics Data System (ADS)

    Truebenbach, Alexandra; Darling, Jeremy

    2018-01-01

    We present the VLBA Extragalactic Proper Motion Catalog, a catalog of extragalactic proper motions created using archival VLBI data and our own VLBA astrometry. The catalog contains 713 proper motions, with average uncertainties of ~ 24 microarcsec/yr, including 40 new or improved proper motion measurements using relative astrometry with the VLBA. We detect the secular aberration drift – the apparent motion of extragalactic objects caused by the solar system's acceleration around the Galactic Center – at 6.3 sigma significance with an amplitude of 1.69 +/- 0.27 microarcsec/yr and an apex consistent with the Galactic Center (275.2 +/- 10.0 deg, -29.4 +/- 8.8 deg). Our dipole model detects the aberration drift at a higher significance than some previous studies (e.g., Titov & Lambert 2013), but at a lower amplitude than expected or previously measured. We then use the correlated relative proper motions of extragalactic objects to place upper limits on the rate of large-scale structure collapse (e.g., Quercellini et al. 2009; Darling 2013). Pairs of small separation objects that are in gravitationally interacting structures such as filaments of large-scale structure will show a net decrease in angular separation (> - 15.5 microarcsec/yr) as they move towards each other, while pairs of large separation objects that are gravitationally unbound and move with the Hubble expansion will show no net change in angular separation. With our catalog, we place a 3 sigma limit on the rate of convergence of large-scale structure of -11.4 microarcsec/yr for extragalactic objects within 100 comoving Mpc of each other. We also confirm that large separation objects (> 800 comoving Mpc) move with the Hubble flow to within ~ 2.2 microarcsec/yr. In the future, we plan to incorporate the upcoming Gaia proper motions into our catalog to achieve a higher precision measurement of the average relative proper motion of gravitationally interacting extragalactic objects and to refine our measurement of the collapse of large-scale structure. This research was performed with support from the NSF grant AST-1411605.Darling, J. 2013, AJ, 777, L21; Quercellini et al. 2009. Phys. Rev. Lett., 102, 151302; Titov, O. & Lambert, S. 2013, A&A, 559, A95

  15. Effects of high sound speed confiners on ANFO detonations

    NASA Astrophysics Data System (ADS)

    Kiyanda, Charles; Jackson, Scott; Short, Mark

    2011-06-01

    The interaction between high explosive (HE) detonations and high sound speed confiners, where the confiner sound speed exceeds the HE's detonation speed, has not been thoroughly studied. The subsonic nature of the flow in the confiner allows stress waves to travel ahead of the main detonation front and influence the upstream HE state. The interaction between the detonation wave and the confiner is also no longer a local interaction, so that the confiner thickness now plays a significant role in the detonation dynamics. We report here on larger scale experiments in which a mixture of ammonium nitrate and fuel oil (ANFO) is detonated in aluminium confiners with varying charge diameter and confiner thickness. The results of these large-scale experiments are compared with previous large-scale ANFO experiments in cardboard, as well as smaller-scale aluminium confined ANFO experiments, to characterize the effects of confiner thickness.

  16. Analysis of ERTS-1 imagery and its application to evaluation of Wyoming's natural resources

    NASA Technical Reports Server (NTRS)

    Houston, R. S. (Principal Investigator); Marrs, R. W.

    1973-01-01

    The author has identified the following significant results. Significant results of the Wyoming ERTS-1 investigation during the first six months (July-December 1972) included: (1) successful segregation of Precambrian metasedimentary/metavolcanic rocks from igneous rocks, (2) discovery of iron formation within the metasedimentary sequence, (3) mapping of previously unreported tectonic elements of major significance, (4) successful mapping of large scale fracture systems of the Wind River Mountains, (5) successful distinction of some metamorphic, igneous, and sedimentary lithologies by color additive viewing, (6) mapping of large scale glacial features, and (7) development of techniques for mapping small urban areas.

  17. Beyond the plane-parallel and Newtonian approach: wide-angle redshift distortions and convergence in general relativity

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bertacca, Daniele; Maartens, Roy; Raccanelli, Alvise

    We extend previous analyses of wide-angle correlations in the galaxy power spectrum in redshift space to include all general relativistic effects. These general relativistic corrections to the standard approach become important on large scales and at high redshifts, and they lead to new terms in the wide-angle correlations. We show that in principle the new terms can produce corrections of nearly 10% on Gpc scales over the usual Newtonian approximation. General relativistic corrections will be important for future large-volume surveys such as SKA and Euclid, although the problem of cosmic variance will present a challenge in observing this.

  18. The brightness temperature of Venus and the absolute flux-density scale at 608 MHz.

    NASA Technical Reports Server (NTRS)

    Muhleman, D. O.; Berge, G. L.; Orton, G. S.

    1973-01-01

    The disk temperature of Venus was measured at 608 MHz near the inferior conjunction of 1972, and a value of 498 plus or minus 33 K was obtained using a nominal CKL flux-density scale. The result is consistent with earlier measurements, but has a much smaller uncertainty. Our theoretical model prediction is larger by a factor of 1.21 plus or minus 0.09. This discrepancy has been noticed previously for frequencies below 1400 MHz, but was generally disregarded because of the large observational uncertainties. No way could be found to change the model to produce agreement without causing a conflict with well-established properties of Venus. Thus it is suggested that the flux-density scale may require an upward revision, at least near this frequency, in excess of what has previously been considered likely.

  19. Interpretation of the cosmic microwave background radiation anisotropy detected by the COBE Differential Microwave Radiometer

    NASA Technical Reports Server (NTRS)

    Wright, E. L.; Meyer, S. S.; Bennett, C. L.; Boggess, N. W.; Cheng, E. S.; Hauser, M. G.; Kogut, A.; Lineweaver, C.; Mather, J. C.; Smoot, G. F.

    1992-01-01

    The large-scale cosmic background anisotropy detected by the COBE Differential Microwave Radiometer (DMR) instrument is compared to the sensitive previous measurements on various angular scales, and to the predictions of a wide variety of models of structure formation driven by gravitational instability. The observed anisotropy is consistent with all previously measured upper limits and with a number of dynamical models of structure formation. For example, the data agree with an unbiased cold dark matter (CDM) model with H0 = 50 km/s Mpc and Delta-M/M = 1 in a 16 Mpc radius sphere. Other models, such as CDM plus massive neutrinos (hot dark matter (HDM)), or CDM with a nonzero cosmological constant are also consistent with the COBE detection and can provide the extra power seen on 5-10,000 km/s scales.

  20. Universal statistics of vortex tangles in three-dimensional random waves

    NASA Astrophysics Data System (ADS)

    Taylor, Alexander J.

    2018-02-01

    The tangled nodal lines (wave vortices) in random, three-dimensional wavefields are studied as an exemplar of a fractal loop soup. Their statistics are a three-dimensional counterpart to the characteristic random behaviour of nodal domains in quantum chaos, but in three dimensions the filaments can wind around one another to give distinctly different large scale behaviours. By tracing numerically the structure of the vortices, their conformations are shown to follow recent analytical predictions for random vortex tangles with periodic boundaries, where the local disorder of the model ‘averages out’ to produce large scale power law scaling relations whose universality classes do not depend on the local physics. These results explain previous numerical measurements in terms of an explicit effect of the periodic boundaries, where the statistics of the vortices are strongly affected by the large scale connectedness of the system even at arbitrarily high energies. The statistics are investigated primarily for static (monochromatic) wavefields, but the analytical results are further shown to directly describe the reconnection statistics of vortices evolving in certain dynamic systems, or occurring during random perturbations of the static configuration.

  1. Comparison of Large eddy dynamo simulation using dynamic sub-grid scale (SGS) model with a fully resolved direct simulation in a rotating spherical shell

    NASA Astrophysics Data System (ADS)

    Matsui, H.; Buffett, B. A.

    2017-12-01

    The flow in the Earth's outer core is expected to have vast length scale from the geometry of the outer core to the thickness of the boundary layer. Because of the limitation of the spatial resolution in the numerical simulations, sub-grid scale (SGS) modeling is required to model the effects of the unresolved field on the large-scale fields. We model the effects of sub-grid scale flow and magnetic field using a dynamic scale similarity model. Four terms are introduced for the momentum flux, heat flux, Lorentz force and magnetic induction. The model was previously used in the convection-driven dynamo in a rotating plane layer and spherical shell using the Finite Element Methods. In the present study, we perform large eddy simulations (LES) using the dynamic scale similarity model. The scale similarity model is implement in Calypso, which is a numerical dynamo model using spherical harmonics expansion. To obtain the SGS terms, the spatial filtering in the horizontal directions is done by taking the convolution of a Gaussian filter expressed in terms of a spherical harmonic expansion, following Jekeli (1981). A Gaussian field is also applied in the radial direction. To verify the present model, we perform a fully resolved direct numerical simulation (DNS) with the truncation of the spherical harmonics L = 255 as a reference. And, we perform unresolved DNS and LES with SGS model on coarser resolution (L= 127, 84, and 63) using the same control parameter as the resolved DNS. We will discuss the verification results by comparison among these simulations and role of small scale fields to large scale fields through the role of the SGS terms in LES.

  2. Speedy routing recovery protocol for large failure tolerance in wireless sensor networks.

    PubMed

    Lee, Joa-Hyoung; Jung, In-Bum

    2010-01-01

    Wireless sensor networks are expected to play an increasingly important role in data collection in hazardous areas. However, the physical fragility of a sensor node makes reliable routing in hazardous areas a challenging problem. Because several sensor nodes in a hazardous area could be damaged simultaneously, the network should be able to recover routing after node failures over large areas. Many routing protocols take single-node failure recovery into account, but it is difficult for these protocols to recover the routing after large-scale failures. In this paper, we propose a routing protocol, referred to as ARF (Adaptive routing protocol for fast Recovery from large-scale Failure), to recover a network quickly after failures over large areas. ARF detects failures by counting the packet losses from parent nodes, and upon failure detection, it decreases the routing interval to notify the neighbor nodes of the failure. Our experimental results indicate that ARF could provide recovery from large-area failures quickly with less packets and energy consumption than previous protocols.

  3. Evaluation of Criteria for the Detection of Fires in Underground Conveyor Belt Haulageways.

    PubMed

    Litton, Charles D; Perera, Inoka Eranda

    2012-07-01

    Large-scale experiments were conducted in an above-ground gallery to simulate typical fires that develop along conveyor belt transport systems within underground coal mines. In the experiments, electrical strip heaters, imbedded ~5 cm below the top surface of a large mass of coal rubble, were used to ignite the coal, producing an open flame. The flaming coal mass subsequently ignited 1.83-meter-wide conveyor belts located approximately 0.30 m above the coal surface. Gas samples were drawn through an averaging probe located approximately 20 m downstream of the coal for continuous measurement of CO, CO 2 , and O 2 as the fire progressed through the stages of smoldering coal, flaming coal, and flaming conveyor belt. Also located approximately 20 m from the fire origin and approximately 0.5 m below the roof of the gallery were two commercially available smoke detectors, a light obscuration meter, and a sampling probe for measurement of total mass concentration of smoke particles. Located upstream of the fire origin and also along the wall of the gallery at approximately 14 m and 5 m upstream were two video cameras capable of both smoke and flame detection. During the experiments, alarm times of the smoke detectors and video cameras were measured while the smoke obscuration and total smoke mass were continually measured. Twelve large-scale experiments were conducted using three different types of fire-resistant conveyor belts and four air velocities for each belt. The air velocities spanned the range from 1.0 m/s to 6.9 m/s. The results of these experiments are compared to previous large-scale results obtained using a smaller fire gallery and much narrower (1.07-m) conveyor belts to determine if the fire detection criteria previously developed (1) remained valid for the wider conveyor belts. Although some differences between these and the previous experiments did occur, the results, in general, compare very favorably. Differences are duly noted and their impact on fire detection discussed.

  4. Mathematical modelling of sewage sludge incineration in a bubbling fluidised bed with special consideration for thermally-thick fuel particles.

    PubMed

    Yang, Yao Bin; Sharifi, Vida; Swithenbank, Jim

    2008-11-01

    Fluidised bed combustor (FBC) is one of the key technologies for sewage sludge incineration. In this paper, a mathematical model is developed for the simulation of a large-scale sewage sludge incineration plant. The model assumes the bed consisting of a fast-gas phase, an emulsion phase and a fuel particle phase with specific consideration for thermally-thick fuel particles. The model further improves over previous works by taking into account throughflow inside the bubbles as well as the floating and random movement of the fuel particles inside the bed. Validation against both previous lab-scale experiments and operational data of a large-scale industrial plant was made. Calculation results indicate that combustion split between the bed and the freeboard can range from 60/40 to 90/10 depending on the fuel particle distribution across the bed height under the specific conditions. The bed performance is heavily affected by the variation in sludge moisture level. The response time to variation in feeding rate is different for different parameters, from 6 min for outlet H2O, 10 min for O2, to 34 min for bed temperature.

  5. Direct evidence for Lyboldsymbol{alpha } depletion in the protocluster core

    NASA Astrophysics Data System (ADS)

    Shimakawa, Rhythm; Kodama, Tadayuki; Hayashi, Masao; Tanaka, Ichi; Matsuda, Yuichi; Kashikawa, Nobunari; Shibuya, Takatoshi; Tadaki, Ken-ichi; Koyama, Yusei; Suzuki, Tomoko L.; Yamamoto, Moegi

    2017-06-01

    We have carried out panoramic Lyα narrow-band imaging with Suprime-Cam on Subaru towards the known protocluster USS1558-003 at z = 2.53. Our previous narrow-band imaging in the near-infrared identified multiple dense groups of Hα emitters (HAEs) within the protocluster. We have now identified the large-scale structures across a ˜50 comoving Mpc scale traced by Lyα emitters (LAEs) in which the protocluster traced by the HAEs is embedded. On a smaller scale, however, there are remarkably few LAEs in the regions of HAE overdensities. Moreover, the stacking analyses of the images show that HAEs in higher-density regions show systematically lower escape fractions of Lyα photons than those of HAEs in lower-density regions. These phenomena may be driven by the extra depletion of Lyα emission lines along our line of sight by more intervening cold circumgalactic/intergalactic medium and/or dust in the dense core. We also caution that all the previous high-z protocluster surveys using LAEs as tracers would have largely missed galaxies in the very dense cores of the protoclusters where we would expect to see any early environmental effects.

  6. Gene expression profiles of auxin metabolism in maturing apple fruit

    USDA-ARS?s Scientific Manuscript database

    Variation exists among apple genotypes in fruit maturation and ripening patterns that influences at-harvest fruit firmness and postharvest storability. Based on the results from our previous large-scale transcriptome profiling on apple fruit maturation and well-documented auxin-ethylene crosstalk, t...

  7. Operations

    ERIC Educational Resources Information Center

    Wilkins, Jesse L. M.; Norton, Anderson; Boyce, Steven J.

    2013-01-01

    Previous research has documented schemes and operations that undergird students' understanding of fractions. This prior research was based, in large part, on small-group teaching experiments. However, written assessments are needed in order for teachers and researchers to assess students' ways of operating on a whole-class scale. In this study,…

  8. Linking marine and freshwater growth in western Alaska Chinook salmon Oncorhynchus tshawytscha

    USGS Publications Warehouse

    Ruggerone, G.T.; Nielsen, J.L.; Agler, B.A.

    2009-01-01

    The hypothesis that growth in Pacific salmon Oncorhynchus spp. is dependent on previous growth was tested using annual scale growth measurements of wild Chinook salmon Oncorhynchus tshawytscha returning to the Yukon and Kuskokwim Rivers, Alaska, from 1964 to 2004. First-year marine growth in individual O. tshawytscha was significantly correlated with growth in fresh water. Furthermore, growth during each of 3 or 4 years at sea was related to growth during the previous year. The magnitude of the growth response to the previous year's growth was greater when mean year-class growth during the previous year was relatively low. Length (eye to tail fork, LETF) of adult O. tshawytscha was correlated with cumulative scale growth after the first year at sea. Adult LETF was also weakly correlated with scale growth that occurred during freshwater residence 4 to 5 years earlier, indicating the importance of growth in fresh water. Positive growth response to previous growth in O. tshawytscha was probably related to piscivorous diet and foraging benefits of large body size. Faster growth among O. tshawytscha year classes that initially grew slowly may reflect high mortality in slow growing fish and subsequent compensatory growth in survivors. Oncorhynchus tshawytscha in this study exhibited complex growth patterns showing a positive relationship with previous growth and a possible compensatory response to environmental factors affecting growth of the age class.

  9. k-neighborhood Decentralization: A Comprehensive Solution to Index the UMLS for Large Scale Knowledge Discovery

    PubMed Central

    Xiang, Yang; Lu, Kewei; James, Stephen L.; Borlawsky, Tara B.; Huang, Kun; Payne, Philip R.O.

    2011-01-01

    The Unified Medical Language System (UMLS) is the largest thesaurus in the biomedical informatics domain. Previous works have shown that knowledge constructs comprised of transitively-associated UMLS concepts are effective for discovering potentially novel biomedical hypotheses. However, the extremely large size of the UMLS becomes a major challenge for these applications. To address this problem, we designed a k-neighborhood Decentralization Labeling Scheme (kDLS) for the UMLS, and the corresponding method to effectively evaluate the kDLS indexing results. kDLS provides a comprehensive solution for indexing the UMLS for very efficient large scale knowledge discovery. We demonstrated that it is highly effective to use kDLS paths to prioritize disease-gene relations across the whole genome, with extremely high fold-enrichment values. To our knowledge, this is the first indexing scheme capable of supporting efficient large scale knowledge discovery on the UMLS as a whole. Our expectation is that kDLS will become a vital engine for retrieving information and generating hypotheses from the UMLS for future medical informatics applications. PMID:22154838

  10. k-Neighborhood decentralization: a comprehensive solution to index the UMLS for large scale knowledge discovery.

    PubMed

    Xiang, Yang; Lu, Kewei; James, Stephen L; Borlawsky, Tara B; Huang, Kun; Payne, Philip R O

    2012-04-01

    The Unified Medical Language System (UMLS) is the largest thesaurus in the biomedical informatics domain. Previous works have shown that knowledge constructs comprised of transitively-associated UMLS concepts are effective for discovering potentially novel biomedical hypotheses. However, the extremely large size of the UMLS becomes a major challenge for these applications. To address this problem, we designed a k-neighborhood Decentralization Labeling Scheme (kDLS) for the UMLS, and the corresponding method to effectively evaluate the kDLS indexing results. kDLS provides a comprehensive solution for indexing the UMLS for very efficient large scale knowledge discovery. We demonstrated that it is highly effective to use kDLS paths to prioritize disease-gene relations across the whole genome, with extremely high fold-enrichment values. To our knowledge, this is the first indexing scheme capable of supporting efficient large scale knowledge discovery on the UMLS as a whole. Our expectation is that kDLS will become a vital engine for retrieving information and generating hypotheses from the UMLS for future medical informatics applications. Copyright © 2011 Elsevier Inc. All rights reserved.

  11. The Observations of Redshift Evolution in Large Scale Environments (ORELSE) Survey

    NASA Astrophysics Data System (ADS)

    Squires, Gordon K.; Lubin, L. M.; Gal, R. R.

    2007-05-01

    We present the motivation, design, and latest results from the Observations of Redshift Evolution in Large Scale Environments (ORELSE) Survey, a systematic search for structure on scales greater than 10 Mpc around 20 known galaxy clusters at z > 0.6. When complete, the survey will cover nearly 5 square degrees, all targeted at high-density regions, making it complementary and comparable to field surveys such as DEEP2, GOODS, and COSMOS. For the survey, we are using the Large Format Camera on the Palomar 5-m and SuPRIME-Cam on the Subaru 8-m to obtain optical/near-infrared imaging of an approximately 30 arcmin region around previously studied high-redshift clusters. Colors are used to identify likely member galaxies which are targeted for follow-up spectroscopy with the DEep Imaging Multi-Object Spectrograph on the Keck 10-m. This technique has been used to identify successfully the Cl 1604 supercluster at z = 0.9, a large scale structure containing at least eight clusters (Gal & Lubin 2004; Gal, Lubin & Squires 2005). We present the most recent structures to be photometrically and spectroscopically confirmed through this program, discuss the properties of the member galaxies as a function of environment, and describe our planned multi-wavelength (radio, mid-IR, and X-ray) observations of these systems. The goal of this survey is to identify and examine a statistical sample of large scale structures during an active period in the assembly history of the most massive clusters. With such a sample, we can begin to constrain large scale cluster dynamics and determine the effect of the larger environment on galaxy evolution.

  12. Modeling the MJO rain rates using parameterized large scale dynamics: vertical structure, radiation, and horizontal advection of dry air

    NASA Astrophysics Data System (ADS)

    Wang, S.; Sobel, A. H.; Nie, J.

    2015-12-01

    Two Madden Julian Oscillation (MJO) events were observed during October and November 2011 in the equatorial Indian Ocean during the DYNAMO field campaign. Precipitation rates and large-scale vertical motion profiles derived from the DYNAMO northern sounding array are simulated in a small-domain cloud-resolving model using parameterized large-scale dynamics. Three parameterizations of large-scale dynamics --- the conventional weak temperature gradient (WTG) approximation, vertical mode based spectral WTG (SWTG), and damped gravity wave coupling (DGW) --- are employed. The target temperature profiles and radiative heating rates are taken from a control simulation in which the large-scale vertical motion is imposed (rather than directly from observations), and the model itself is significantly modified from that used in previous work. These methodological changes lead to significant improvement in the results.Simulations using all three methods, with imposed time -dependent radiation and horizontal moisture advection, capture the time variations in precipitation associated with the two MJO events well. The three methods produce significant differences in the large-scale vertical motion profile, however. WTG produces the most top-heavy and noisy profiles, while DGW's is smoother with a peak in midlevels. SWTG produces a smooth profile, somewhere between WTG and DGW, and in better agreement with observations than either of the others. Numerical experiments without horizontal advection of moisture suggest that that process significantly reduces the precipitation and suppresses the top-heaviness of large-scale vertical motion during the MJO active phases, while experiments in which the effect of cloud on radiation are disabled indicate that cloud-radiative interaction significantly amplifies the MJO. Experiments in which interactive radiation is used produce poorer agreement with observation than those with imposed time-varying radiative heating. Our results highlight the importance of both horizontal advection of moisture and cloud-radiative feedback to the dynamics of the MJO, as well as to accurate simulation and prediction of it in models.

  13. Large-scale bioenergy production: how to resolve sustainability trade-offs?

    NASA Astrophysics Data System (ADS)

    Humpenöder, Florian; Popp, Alexander; Bodirsky, Benjamin Leon; Weindl, Isabelle; Biewald, Anne; Lotze-Campen, Hermann; Dietrich, Jan Philipp; Klein, David; Kreidenweis, Ulrich; Müller, Christoph; Rolinski, Susanne; Stevanovic, Miodrag

    2018-02-01

    Large-scale 2nd generation bioenergy deployment is a key element of 1.5 °C and 2 °C transformation pathways. However, large-scale bioenergy production might have negative sustainability implications and thus may conflict with the Sustainable Development Goal (SDG) agenda. Here, we carry out a multi-criteria sustainability assessment of large-scale bioenergy crop production throughout the 21st century (300 EJ in 2100) using a global land-use model. Our analysis indicates that large-scale bioenergy production without complementary measures results in negative effects on the following sustainability indicators: deforestation, CO2 emissions from land-use change, nitrogen losses, unsustainable water withdrawals and food prices. One of our main findings is that single-sector environmental protection measures next to large-scale bioenergy production are prone to involve trade-offs among these sustainability indicators—at least in the absence of more efficient land or water resource use. For instance, if bioenergy production is accompanied by forest protection, deforestation and associated emissions (SDGs 13 and 15) decline substantially whereas food prices (SDG 2) increase. However, our study also shows that this trade-off strongly depends on the development of future food demand. In contrast to environmental protection measures, we find that agricultural intensification lowers some side-effects of bioenergy production substantially (SDGs 13 and 15) without generating new trade-offs—at least among the sustainability indicators considered here. Moreover, our results indicate that a combination of forest and water protection schemes, improved fertilization efficiency, and agricultural intensification would reduce the side-effects of bioenergy production most comprehensively. However, although our study includes more sustainability indicators than previous studies on bioenergy side-effects, our study represents only a small subset of all indicators relevant for the SDG agenda. Based on this, we argue that the development of policies for regulating externalities of large-scale bioenergy production should rely on broad sustainability assessments to discover potential trade-offs with the SDG agenda before implementation.

  14. A Combined Ethical and Scientific Analysis of Large-scale Tests of Solar Climate Engineering

    NASA Astrophysics Data System (ADS)

    Ackerman, T. P.

    2017-12-01

    Our research group recently published an analysis of the combined ethical and scientific issues surrounding large-scale testing of stratospheric aerosol injection (SAI; Lenferna et al., 2017, Earth's Future). We are expanding this study in two directions. The first is extending this same analysis to other geoengineering techniques, particularly marine cloud brightening (MCB). MCB has substantial differences to SAI in this context because MCB can be tested over significantly smaller areas of the planet and, following injection, has a much shorter lifetime of weeks as opposed to years for SAI. We examine issues such as the role of intent, the lesser of two evils, and the nature of consent. In addition, several groups are currently considering climate engineering governance tools such as a code of ethics and a registry. We examine how these tools might influence climate engineering research programs and, specifically, large-scale testing. The second direction of expansion is asking whether ethical and scientific issues associated with large-scale testing are so significant that they effectively preclude moving ahead with climate engineering research and testing. Some previous authors have suggested that no research should take place until these issues are resolved. We think this position is too draconian and consider a more nuanced version of this argument. We note, however, that there are serious questions regarding the ability of the scientific research community to move to the point of carrying out large-scale tests.

  15. Cl-Assisted Large Scale Synthesis of Cm-Scale Buckypapers of Fe₃C-Filled Carbon Nanotubes with Pseudo-Capacitor Properties: The Key Role of SBA-16 Catalyst Support as Synthesis Promoter.

    PubMed

    Boi, Filippo S; He, Yi; Wen, Jiqiu; Wang, Shanling; Yan, Kai; Zhang, Jingdong; Medranda, Daniel; Borowiec, Joanna; Corrias, Anna

    2017-10-23

    We show a novel chemical vapour deposition (CVD) approach, in which the large-scale fabrication of ferromagnetically-filled cm-scale buckypapers is achieved through the deposition of a mesoporous supported catalyst (SBA-16) on a silicon substrate. We demonstrate that SBA-16 has the crucial role of promoting the growth of carbon nanotubes (CNTs) on a horizontal plane with random orientation rather than in a vertical direction, therefore allowing a facile fabrication of cm-scale CNTs buckypapers free from the onion-crust by-product observed on the buckypaper-surface in previous reports. The morphology and composition of the obtained CNTs-buckypapers are analyzed in detail by scanning electron microscopy (SEM), Energy Dispersive X-ray (EDX), transmission electron microscopy (TEM), high resolution TEM (HRTEM), and thermogravimetric analysis (TGA), while structural analysis is performed by Rietveld Refinement of XRD data. The room temperature magnetic properties of the produced buckypapers are also investigated and reveal the presence of a high coercivity of 650 Oe. Additionally, the electrochemical performances of these buckypapers are demonstrated and reveal a behavior that is compatible with that of a pseudo-capacitor (resistive-capacitor) with better performances than those presented in other previously studied layered-buckypapers of Fe-filled CNTs, obtained by pyrolysis of dichlorobenzene-ferrocene mixtures. These measurements indicate that these materials show promise for applications in energy storage systems as flexible electrodes.

  16. Examples of backreaction of small-scale inhomogeneities in cosmology

    NASA Astrophysics Data System (ADS)

    Green, Stephen R.; Wald, Robert M.

    2013-06-01

    In previous work, we introduced a new framework to treat large-scale backreaction effects due to small-scale inhomogeneities in general relativity. We considered one-parameter families of spacetimes for which such backreaction effects can occur, and we proved that, provided the weak energy condition on matter is satisfied, the leading effect of small-scale inhomogeneities on large-scale dynamics is to produce a traceless effective stress-energy tensor that itself satisfies the weak energy condition. In this work, we illustrate the nature of our framework by providing two explicit examples of one-parameter families with backreaction. The first, based on previous work of Berger, is a family of polarized vacuum Gowdy spacetimes on a torus, which satisfies all of the assumptions of our framework. As the parameter approaches its limiting value, the metric uniformly approaches a smooth background metric, but spacetime derivatives of the deviation of the metric from the background metric do not converge uniformly to zero. The limiting metric has nontrivial backreaction from the small-scale inhomogeneities, with an effective stress energy that is traceless and satisfies the weak energy condition, in accord with our theorems. Our second one-parameter family consists of metrics which have a uniform Friedmann-Lemaître-Robertson-Walker limit. This family satisfies all of our assumptions with the exception of the weak energy condition for matter. In this case, the limiting metric has an effective stress-energy tensor which is not traceless. We emphasize the importance of imposing energy conditions on matter in studies of backreaction.

  17. The circuit architecture of whole brains at the mesoscopic scale.

    PubMed

    Mitra, Partha P

    2014-09-17

    Vertebrate brains of even moderate size are composed of astronomically large numbers of neurons and show a great degree of individual variability at the microscopic scale. This variation is presumably the result of phenotypic plasticity and individual experience. At a larger scale, however, relatively stable species-typical spatial patterns are observed in neuronal architecture, e.g., the spatial distributions of somata and axonal projection patterns, probably the result of a genetically encoded developmental program. The mesoscopic scale of analysis of brain architecture is the transitional point between a microscopic scale where individual variation is prominent and the macroscopic level where a stable, species-typical neural architecture is observed. The empirical existence of this scale, implicit in neuroanatomical atlases, combined with advances in computational resources, makes studying the circuit architecture of entire brains a practical task. A methodology has previously been proposed that employs a shotgun-like grid-based approach to systematically cover entire brain volumes with injections of neuronal tracers. This methodology is being employed to obtain mesoscale circuit maps in mouse and should be applicable to other vertebrate taxa. The resulting large data sets raise issues of data representation, analysis, and interpretation, which must be resolved. Even for data representation the challenges are nontrivial: the conventional approach using regional connectivity matrices fails to capture the collateral branching patterns of projection neurons. Future success of this promising research enterprise depends on the integration of previous neuroanatomical knowledge, partly through the development of suitable computational tools that encapsulate such expertise. Copyright © 2014 Elsevier Inc. All rights reserved.

  18. Utilisation of ISA Reverse Genetics and Large-Scale Random Codon Re-Encoding to Produce Attenuated Strains of Tick-Borne Encephalitis Virus within Days.

    PubMed

    de Fabritus, Lauriane; Nougairède, Antoine; Aubry, Fabien; Gould, Ernest A; de Lamballerie, Xavier

    2016-01-01

    Large-scale codon re-encoding is a new method of attenuating RNA viruses. However, the use of infectious clones to generate attenuated viruses has inherent technical problems. We previously developed a bacterium-free reverse genetics protocol, designated ISA, and now combined it with large-scale random codon-re-encoding method to produce attenuated tick-borne encephalitis virus (TBEV), a pathogenic flavivirus which causes febrile illness and encephalitis in humans. We produced wild-type (WT) and two re-encoded TBEVs, containing 273 or 273+284 synonymous mutations in the NS5 and NS5+NS3 coding regions respectively. Both re-encoded viruses were attenuated when compared with WT virus using a laboratory mouse model and the relative level of attenuation increased with the degree of re-encoding. Moreover, all infected animals produced neutralizing antibodies. This novel, rapid and efficient approach to engineering attenuated viruses could potentially expedite the development of safe and effective new-generation live attenuated vaccines.

  19. Tomato functional genomics database (TFGD): a comprehensive collection and analysis package for tomato functional genomics

    USDA-ARS?s Scientific Manuscript database

    Tomato Functional Genomics Database (TFGD; http://ted.bti.cornell.edu) provides a comprehensive systems biology resource to store, mine, analyze, visualize and integrate large-scale tomato functional genomics datasets. The database is expanded from the previously described Tomato Expression Database...

  20. Cutting Off the Head of the Snake: Foreign Imposed Regime Change

    DTIC Science & Technology

    2018-06-15

    looked overwhelmingly female and/or elderly.”8 The population and common soldier became prey to a constant stream of bombing on a scale never previously...into enemy hands, and murdered their civilian compatriots in places such as Saipan and Okinawa. They watched helplessly as fire bombs destroyed...fatalities from bombing resulting in a loss of the will to fight, but did not suffer large scale losses.6 Rather, they decided to stop fighting in a

  1. cOSPREY: A Cloud-Based Distributed Algorithm for Large-Scale Computational Protein Design

    PubMed Central

    Pan, Yuchao; Dong, Yuxi; Zhou, Jingtian; Hallen, Mark; Donald, Bruce R.; Xu, Wei

    2016-01-01

    Abstract Finding the global minimum energy conformation (GMEC) of a huge combinatorial search space is the key challenge in computational protein design (CPD) problems. Traditional algorithms lack a scalable and efficient distributed design scheme, preventing researchers from taking full advantage of current cloud infrastructures. We design cloud OSPREY (cOSPREY), an extension to a widely used protein design software OSPREY, to allow the original design framework to scale to the commercial cloud infrastructures. We propose several novel designs to integrate both algorithm and system optimizations, such as GMEC-specific pruning, state search partitioning, asynchronous algorithm state sharing, and fault tolerance. We evaluate cOSPREY on three different cloud platforms using different technologies and show that it can solve a number of large-scale protein design problems that have not been possible with previous approaches. PMID:27154509

  2. Effect of weak rotation on large-scale circulation cessations in turbulent convection.

    PubMed

    Assaf, Michael; Angheluta, Luiza; Goldenfeld, Nigel

    2012-08-17

    We investigate the effect of weak rotation on the large-scale circulation (LSC) of turbulent Rayleigh-Bénard convection, using the theory for cessations in a low-dimensional stochastic model of the flow previously studied. We determine the cessation frequency of the LSC as a function of rotation, and calculate the statistics of the amplitude and azimuthal velocity fluctuations of the LSC as a function of the rotation rate for different Rayleigh numbers. Furthermore, we show that the tails of the reorientation PDF remain unchanged for rotating systems, while the distribution of the LSC amplitude and correspondingly the cessation frequency are strongly affected by rotation. Our results are in close agreement with experimental observations.

  3. Efficient estimation and large-scale evaluation of lateral chromatic aberration for digital image forensics

    NASA Astrophysics Data System (ADS)

    Gloe, Thomas; Borowka, Karsten; Winkler, Antje

    2010-01-01

    The analysis of lateral chromatic aberration forms another ingredient for a well equipped toolbox of an image forensic investigator. Previous work proposed its application to forgery detection1 and image source identification.2 This paper takes a closer look on the current state-of-the-art method to analyse lateral chromatic aberration and presents a new approach to estimate lateral chromatic aberration in a runtime-efficient way. Employing a set of 11 different camera models including 43 devices, the characteristic of lateral chromatic aberration is investigated in a large-scale. The reported results point to general difficulties that have to be considered in real world investigations.

  4. Size effects in olivine control strength in low-temperature plasticity regime

    NASA Astrophysics Data System (ADS)

    Kumamoto, K. M.; Thom, C.; Wallis, D.; Hansen, L. N.; Armstrong, D. E. J.; Goldsby, D. L.; Warren, J. M.; Wilkinson, A. J.

    2017-12-01

    The strength of the lithospheric mantle during deformation by low-temperature plasticity controls a range of geological phenomena, including lithospheric-scale strain localization, the evolution of friction on deep seismogenic faults, and the flexure of tectonic plates. However, constraints on the strength of olivine in this deformation regime are difficult to obtain from conventional rock-deformation experiments, and previous results vary considerably. We demonstrate via nanoindentation that the strength of olivine in the low-temperature plasticity regime is dependent on the length-scale of the test, with experiments on smaller volumes of material exhibiting larger yield stresses. This "size effect" has previously been explained in engineering materials as a result of the role of strain gradients and associated geometrically necessary dislocations in modifying plastic behavior. The Hall-Petch effect, in which a material with a small grain size exhibits a higher strength than one with a large grain size, is thought to arise from the same mechanism. The presence of a size effect resolves discrepancies among previous experimental measurements of olivine, which were either conducted using indentation methods or were conducted on polycrystalline samples with small grain sizes. An analysis of different low-temperature plasticity flow laws extrapolated to room temperature reveals a power-law relationship between length-scale (grain size for polycrystalline deformation and contact radius for indentation tests) and yield strength. This suggests that data from samples with large inherent length scales best represent the plastic strength of the coarse-grained lithospheric mantle. Additionally, the plastic deformation of nanometer- to micrometer-sized asperities on fault surfaces may control the evolution of fault roughness due to their size-dependent strength.

  5. The spatial and temporal domains of modern ecology.

    PubMed

    Estes, Lyndon; Elsen, Paul R; Treuer, Timothy; Ahmed, Labeeb; Caylor, Kelly; Chang, Jason; Choi, Jonathan J; Ellis, Erle C

    2018-05-01

    To understand ecological phenomena, it is necessary to observe their behaviour across multiple spatial and temporal scales. Since this need was first highlighted in the 1980s, technology has opened previously inaccessible scales to observation. To help to determine whether there have been corresponding changes in the scales observed by modern ecologists, we analysed the resolution, extent, interval and duration of observations (excluding experiments) in 348 studies that have been published between 2004 and 2014. We found that observational scales were generally narrow, because ecologists still primarily use conventional field techniques. In the spatial domain, most observations had resolutions ≤1 m 2 and extents ≤10,000 ha. In the temporal domain, most observations were either unreplicated or infrequently repeated (>1 month interval) and ≤1 year in duration. Compared with studies conducted before 2004, observational durations and resolutions appear largely unchanged, but intervals have become finer and extents larger. We also found a large gulf between the scales at which phenomena are actually observed and the scales those observations ostensibly represent, raising concerns about observational comprehensiveness. Furthermore, most studies did not clearly report scale, suggesting that it remains a minor concern. Ecologists can better understand the scales represented by observations by incorporating autocorrelation measures, while journals can promote attentiveness to scale by implementing scale-reporting standards.

  6. Sterile neutrinos with secret interactions—lasting friendship with cosmology

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chu, Xiaoyong; Dasgupta, Basudeb; Kopp, Joachim, E-mail: xchu@ictp.it, E-mail: bdasgupta@theory.tifr.res.in, E-mail: jkopp@uni-mainz.de

    Sterile neutrinos with mass ≅ 1 eV and order 10% mixing with active neutrinos have been proposed as a solution to anomalies in neutrino oscillation data, but are tightly constrained by cosmological limits. It was recently shown that these constraints are avoided if sterile neutrinos couple to a new MeV-scale gauge boson A'. However, even this scenario is restricted by structure formation constraints when A'-mediated collisional processes lead to efficient active-to-sterile neutrino conversion after neutrinos have decoupled. In view of this, we reevaluate in this paper the viability of sterile neutrinos with such ''secret'' interactions. We carefully dissect their evolution inmore » the early Universe, including the various production channels and the expected modifications to large scale structure formation. We argue that there are two regions in parameter space—one at very small A' coupling, one at relatively large A' coupling—where all constraints from big bang nucleosynthesis (BBN), cosmic microwave background (CMB), and large scale structure (LSS) data are satisfied. Interestingly, the large A' coupling region is precisely the region that was previously shown to have potentially important consequences for the small scale structure of dark matter halos if the A' boson couples also to the dark matter in the Universe.« less

  7. A Ranking Approach on Large-Scale Graph With Multidimensional Heterogeneous Information.

    PubMed

    Wei, Wei; Gao, Bin; Liu, Tie-Yan; Wang, Taifeng; Li, Guohui; Li, Hang

    2016-04-01

    Graph-based ranking has been extensively studied and frequently applied in many applications, such as webpage ranking. It aims at mining potentially valuable information from the raw graph-structured data. Recently, with the proliferation of rich heterogeneous information (e.g., node/edge features and prior knowledge) available in many real-world graphs, how to effectively and efficiently leverage all information to improve the ranking performance becomes a new challenging problem. Previous methods only utilize part of such information and attempt to rank graph nodes according to link-based methods, of which the ranking performances are severely affected by several well-known issues, e.g., over-fitting or high computational complexity, especially when the scale of graph is very large. In this paper, we address the large-scale graph-based ranking problem and focus on how to effectively exploit rich heterogeneous information of the graph to improve the ranking performance. Specifically, we propose an innovative and effective semi-supervised PageRank (SSP) approach to parameterize the derived information within a unified semi-supervised learning framework (SSLF-GR), then simultaneously optimize the parameters and the ranking scores of graph nodes. Experiments on the real-world large-scale graphs demonstrate that our method significantly outperforms the algorithms that consider such graph information only partially.

  8. [A large-scale accident in Alpine terrain].

    PubMed

    Wildner, M; Paal, P

    2015-02-01

    Due to the geographical conditions, large-scale accidents amounting to mass casualty incidents (MCI) in Alpine terrain regularly present rescue teams with huge challenges. Using an example incident, specific conditions and typical problems associated with such a situation are presented. The first rescue team members to arrive have the elementary tasks of qualified triage and communication to the control room, which is required to dispatch the necessary additional support. Only with a clear "concept", to which all have to adhere, can the subsequent chaos phase be limited. In this respect, a time factor confounded by adverse weather conditions or darkness represents enormous pressure. Additional hazards are frostbite and hypothermia. If priorities can be established in terms of urgency, then treatment and procedure algorithms have proven successful. For evacuation of causalities, a helicopter should be strived for. Due to the low density of hospitals in Alpine regions, it is often necessary to distribute the patients over a wide area. Rescue operations in Alpine terrain have to be performed according to the particular conditions and require rescue teams to have specific knowledge and expertise. The possibility of a large-scale accident should be considered when planning events. With respect to optimization of rescue measures, regular training and exercises are rational, as is the analysis of previous large-scale Alpine accidents.

  9. The Future of Data-Enriched Assessment

    ERIC Educational Resources Information Center

    Thille, Candace; Schneider, Emily; Kizilcec, René F.; Piech, Christopher; Halawa, Sherif A.; Greene, Daniel K.

    2014-01-01

    The article addresses the question of how the assessment process with large-scale data derived from online learning environments will be different from the assessment process without it. Following an explanation of big data and how it is different from previously available learner data, we describe three notable features that characterize…

  10. Disaggregated Effects of Device on Score Comparability

    ERIC Educational Resources Information Center

    Davis, Laurie; Morrison, Kristin; Kong, Xiaojing; McBride, Yuanyuan

    2017-01-01

    The use of tablets for large-scale testing programs has transitioned from concept to reality for many state testing programs. This study extended previous research on score comparability between tablets and computers with high school students to compare score distributions across devices for reading, math, and science and to evaluate device…

  11. Early stage litter decomposition across biomes

    Treesearch

    Ika Djukic; Sebastian Kepfer-Rojas; Inger Kappel Schmidt; Klaus Steenberg Larsen; Claus Beier; Björn Berg; Kris Verheyen; Adriano Caliman; Alain Paquette; Alba Gutiérrez-Girón; Alberto Humber; Alejandro Valdecantos; Alessandro Petraglia; Heather Alexander; Algirdas Augustaitis; Amélie Saillard; Ana Carolina Ruiz Fernández; Ana I. Sousa; Ana I. Lillebø; Anderson da Rocha Gripp; André-Jean Francez; Andrea Fischer; Andreas Bohner; Andrey Malyshev; Andrijana Andrić; Andy Smith; Angela Stanisci; Anikó Seres; Anja Schmidt; Anna Avila; Anne Probst; Annie Ouin; Anzar A. Khuroo; Arne Verstraeten; Arely N. Palabral-Aguilera; Artur Stefanski; Aurora Gaxiola; Bart Muys; Bernard Bosman; Bernd Ahrends; Bill Parker; Birgit Sattler; Bo Yang; Bohdan Juráni; Brigitta Erschbamer; Carmen Eugenia Rodriguez Ortiz; Casper T. Christiansen; E. Carol Adair; Céline Meredieu; Cendrine Mony; Charles A. Nock; Chi-Ling Chen; Chiao-Ping Wang; Christel Baum; Christian Rixen; Christine Delire; Christophe Piscart; Christopher Andrews; Corinna Rebmann; Cristina Branquinho; Dana Polyanskaya; David Fuentes Delgado; Dirk Wundram; Diyaa Radeideh; Eduardo Ordóñez-Regil; Edward Crawford; Elena Preda; Elena Tropina; Elli Groner; Eric Lucot; Erzsébet Hornung; Esperança Gacia; Esther Lévesque; Evanilde Benedito; Evgeny A. Davydov; Evy Ampoorter; Fabio Padilha Bolzan; Felipe Varela; Ferdinand Kristöfel; Fernando T. Maestre; Florence Maunoury-Danger; Florian Hofhansl; Florian Kitz; Flurin Sutter; Francisco Cuesta; Francisco de Almeida Lobo; Franco Leandro de Souza; Frank Berninger; Franz Zehetner; Georg Wohlfahrt; George Vourlitis; Geovana Carreño-Rocabado; Gina Arena; Gisele Daiane Pinha; Grizelle González; Guylaine Canut; Hanna Lee; Hans Verbeeck; Harald Auge; Harald Pauli; Hassan Bismarck Nacro; Héctor A. Bahamonde; Heike Feldhaar; Heinke Jäger; Helena C. Serrano; Hélène Verheyden; Helge Bruelheide; Henning Meesenburg; Hermann Jungkunst; Hervé Jactel; Hideaki Shibata; Hiroko Kurokawa; Hugo López Rosas; Hugo L. Rojas Villalobos; Ian Yesilonis; Inara Melece; Inge Van Halder; Inmaculada García Quirós; Isaac Makelele; Issaka Senou; István Fekete; Ivan Mihal; Ivika Ostonen; Jana Borovská; Javier Roales; Jawad Shoqeir; Jean-Christophe Lata; Jean-Paul Theurillat; Jean-Luc Probst; Jess Zimmerman; Jeyanny Vijayanathan; Jianwu Tang; Jill Thompson; Jiří Doležal; Joan-Albert Sanchez-Cabeza; Joël Merlet; Joh Henschel; Johan Neirynck; Johannes Knops; John Loehr; Jonathan von Oppen; Jónína Sigríður Þorláksdóttir; Jörg Löffler; José-Gilberto Cardoso-Mohedano; José-Luis Benito-Alonso; Jose Marcelo Torezan; Joseph C. Morina; Juan J. Jiménez; Juan Dario Quinde; Juha Alatalo; Julia Seeber; Jutta Stadler; Kaie Kriiska; Kalifa Coulibaly; Karibu Fukuzawa; Katalin Szlavecz; Katarína Gerhátová; Kate Lajtha; Kathrin Käppeler; Katie A. Jennings; Katja Tielbörger; Kazuhiko Hoshizaki; Ken Green; Lambiénou Yé; Laryssa Helena Ribeiro Pazianoto; Laura Dienstbach; Laura Williams; Laura Yahdjian; Laurel M. Brigham; Liesbeth van den Brink; Lindsey Rustad; al. et

    2018-01-01

    Through litter decomposition enormous amounts of carbon is emitted to the atmosphere. Numerous large-scale decomposition experiments have been conducted focusing on this fundamental soil process in order to understand the controls on the terrestrial carbon transfer to the atmosphere. However, previous studies were mostly based on site-specific litter and methodologies...

  12. Three Conceptual Replication Studies in Group Theory

    ERIC Educational Resources Information Center

    Melhuish, Kathleen

    2018-01-01

    Many studies in mathematics education research occur with a nonrepresentative sample and are never replicated. To challenge this paradigm, I designed a large-scale study evaluating student conceptions in group theory that surveyed a national, representative sample of students. By replicating questions previously used to build theory around student…

  13. Comparison of emerging contaminants in receiving waters downstream of a conventional wastewater treatment plant and a forest-water reuse system

    EPA Science Inventory

    Forest-water reuse (FWR) systems treat municipal, industrial, and agricultural wastewaters via land application to forest soils. Previous studies have shown that both large-scale conventional wastewater treatment plants (WWTPs) and FWR systems do not completely remove many contam...

  14. Psychological Science, Talent Development, and Educational Advocacy: Lost in Translation?

    ERIC Educational Resources Information Center

    Robinson, Ann

    2012-01-01

    The talent development approach to the conceptualization of giftedness has historical precedent in the field. Examples of large-scale and longitudinal research studies from previous decades guided by the talent development approach are provided as illustrations. The implications of focusing on domain-specific talents in academics, the arts and…

  15. Motivation to Read among Rural Adolescents

    ERIC Educational Resources Information Center

    Belken, Gloria

    2013-01-01

    This study used quantitative methods to investigate motivation to read among high school students in a tenth-grade English course at a rural high school in the Midwestern USA. Data were collected and analyzed to replicate previous studies. In this study, when compared to large-scale surveys, respondents showed more positive attitudes toward…

  16. Solving the shrinkage-induced PDMS alignment registration issue in multilayer soft lithography

    NASA Astrophysics Data System (ADS)

    Moraes, Christopher; Sun, Yu; Simmons, Craig A.

    2009-06-01

    Shrinkage of polydimethylsiloxane (PDMS) complicates alignment registration between layers during multilayer soft lithography fabrication. This often hinders the development of large-scale microfabricated arrayed devices. Here we report a rapid method to construct large-area, multilayered devices with stringent alignment requirements. This technique, which exploits a previously unrecognized aspect of sandwich mold fabrication, improves device yield, enables highly accurate alignment over large areas of multilayered devices and does not require strict regulation of fabrication conditions or extensive calibration processes. To demonstrate this technique, a microfabricated Braille display was developed and characterized. High device yield and accurate alignment within 15 µm were achieved over three layers for an array of 108 Braille units spread over a 6.5 cm2 area, demonstrating the fabrication of well-aligned devices with greater ease and efficiency than previously possible.

  17. DEMNUni: massive neutrinos and the bispectrum of large scale structures

    NASA Astrophysics Data System (ADS)

    Ruggeri, Rossana; Castorina, Emanuele; Carbone, Carmelita; Sefusatti, Emiliano

    2018-03-01

    The main effect of massive neutrinos on the large-scale structure consists in a few percent suppression of matter perturbations on all scales below their free-streaming scale. Such effect is of particular importance as it allows to constraint the value of the sum of neutrino masses from measurements of the galaxy power spectrum. In this work, we present the first measurements of the next higher-order correlation function, the bispectrum, from N-body simulations that include massive neutrinos as particles. This is the simplest statistics characterising the non-Gaussian properties of the matter and dark matter halos distributions. We investigate, in the first place, the suppression due to massive neutrinos on the matter bispectrum, comparing our measurements with the simplest perturbation theory predictions, finding the approximation of neutrinos contributing at quadratic order in perturbation theory to provide a good fit to the measurements in the simulations. On the other hand, as expected, a linear approximation for neutrino perturbations would lead to Script O(fν) errors on the total matter bispectrum at large scales. We then attempt an extension of previous results on the universality of linear halo bias in neutrino cosmologies, to non-linear and non-local corrections finding consistent results with the power spectrum analysis.

  18. Evaluation of Kirkwood-Buff integrals via finite size scaling: a large scale molecular dynamics study

    NASA Astrophysics Data System (ADS)

    Dednam, W.; Botha, A. E.

    2015-01-01

    Solvation of bio-molecules in water is severely affected by the presence of co-solvent within the hydration shell of the solute structure. Furthermore, since solute molecules can range from small molecules, such as methane, to very large protein structures, it is imperative to understand the detailed structure-function relationship on the microscopic level. For example, it is useful know the conformational transitions that occur in protein structures. Although such an understanding can be obtained through large-scale molecular dynamic simulations, it is often the case that such simulations would require excessively large simulation times. In this context, Kirkwood-Buff theory, which connects the microscopic pair-wise molecular distributions to global thermodynamic properties, together with the recently developed technique, called finite size scaling, may provide a better method to reduce system sizes, and hence also the computational times. In this paper, we present molecular dynamics trial simulations of biologically relevant low-concentration solvents, solvated by aqueous co-solvent solutions. In particular we compare two different methods of calculating the relevant Kirkwood-Buff integrals. The first (traditional) method computes running integrals over the radial distribution functions, which must be obtained from large system-size NVT or NpT simulations. The second, newer method, employs finite size scaling to obtain the Kirkwood-Buff integrals directly by counting the particle number fluctuations in small, open sub-volumes embedded within a larger reservoir that can be well approximated by a much smaller simulation cell. In agreement with previous studies, which made a similar comparison for aqueous co-solvent solutions, without the additional solvent, we conclude that the finite size scaling method is also applicable to the present case, since it can produce computationally more efficient results which are equivalent to the more costly radial distribution function method.

  19. Distributions and Changes of Carbonate Parameters Along the U.S. East Coast

    NASA Astrophysics Data System (ADS)

    Xu, Y. Y.; Cai, W. J.; Wanninkhof, R. H.; Salisbury, J., II

    2017-12-01

    On top of anthropogenic climate change, upwelling, eutrophication, river discharge, and interactions with the open ocean have affected carbonate chemistry in coastal waters. In this study, we present the large-scale variations of carbonate parameters along the U.S. east coast using in situ observations obtained during an East Coast Ocean Acidification (ECOA) cruise in summer 2015. Compare with previous large-scale cruises along the east coast, the ECOA cruise increases spatial coverage in the Gulf of Marine region and has more offshore stations for a better understanding of carbon dynamics in coastal waters and their interactions with open ocean waters. Our results show that the spatial distribution of water mass properties set up the large-scale advection of salt and heat and the distribution of total alkalinity (TA). However, dissolved inorganic carbon (DIC) shows a distinct pattern. Coastal water pH displays high variability in the Gulf of Maine and the Mid-Atlantic Bight (MAB). But it is relatively homogeneous in the South Atlantic Bight (SAB). In contrast, the distribution of aragonite saturation state (Ω) has an increase pattern from north to south similar to those of TA, SST, and SSS. A mechanistic discussion will be presented to understand the controls on Ω in eastern coastal waters. A comparison with previous cruises also suggests very different changes of pH and Ω in the MAB and SAB. Preliminary analysis suggests an overall increase in surface pH and Ω in the MAB. In contrast, pH and Ω in the SAB surface waters decrease over the past two decades. This work serves as a platform for the monitoring of large-scale carbon cycling in the U.S. east coast. It is also important to identify the physical and biogeochemical processes that affect these distributions and changes over time for a better understanding of carbon cycling and ocean acidification in coastal waters.

  20. A follow-up study of hygiene in catering premises at large-scale events in the United Kingdom.

    PubMed

    Willis, C; Elviss, N; McLauchlin, J

    2015-01-01

    To investigate food hygiene practices at large events by assessing the microbiological quality of ready-to-eat food, drinking water, food preparation surfaces, cleaning cloths and wristbands worn by food handlers for event security purposes. Over a 7-month period, 1662 samples were collected at 153 events and examined for microbiological contamination. Eight per cent of food samples were of an unsatisfactory quality. A further one per cent contained potentially hazardous levels of human pathogenic bacteria. 27% of water samples, 32% of swabs and 56% of cloths were also unsatisfactory. These results represented an improvement in hygiene compared to a previous study carried out 12 months previously. A fifth of food handler wristbands were contaminated with Enterobacteriaceae, Escherichia coli and/or coagulase-positive staphylococci, with those bands made from fabric being more frequently contaminated than those made from plastic or other materials. This study provides evidence that the food hygiene at large-scale events may have improved. However, there is still a need for continued efforts to maintain an ongoing improvement in cleaning regimes and food hygiene management. This study was part of an ongoing focus on large events in the lead-up to the London 2012 Olympics. Lessons learnt here will be important in the planning of future large events. © 2014 Crown copyright. © 2014 Society for Applied Microbiology This article is Published with the permission of the Controller of HMSO and Queen's Printer for Scotland.

  1. Lensing of the CMB: non-Gaussian aspects.

    PubMed

    Zaldarriaga, M

    2001-06-01

    We compute the small angle limit of the three- and four-point function of the cosmic microwave background (CMB) temperature induced by the gravitational lensing effect by the large-scale structure of the universe. We relate the non-Gaussian aspects presented in this paper with those in our previous studies of the lensing effects. We interpret the statistics proposed in previous work in terms of different configurations of the four-point function and show how they relate to the statistic that maximizes the S/N.

  2. Streak instability as an initiating mechanism of the large-scale motions in a turbulent channel flow

    NASA Astrophysics Data System (ADS)

    de Giovanetti, Matteo; Sung, Hyung Jin; Hwang, Yongyun

    2016-11-01

    The large-scale motions (or bulges) have often been believed to be formed via merge and/or growth of the near-wall hairpin vortical structures. Here, we report our observation that they can be directly generated by an instability of the amplified streaky motions in the outer region (i.e. very-large-scale motions) through the self-sustaining process. We design a LES-based numerical experiment in turbulent channel flow for Reτ = 2000 where a body forcing is implemented to artificially drive an infinitely long streaky motion in the outer layer. As the forcing amplitude is increased, it is found that a new energetic structure emerges at λx 3 4 h of the streamwise length (h is the half height of channel) particularly in the wall-normal and spanwise velocities. A careful statistical examination reveals that this structure is likely to be linked with the sinuous-mode streak instability of the amplified streak, consistent with previous theoretical studies. Application of dynamic mode decomposition to this instability further shows that the phase speed of this structure scales with the outer velocity and it is initiated around the critical layer of the streaky flow.

  3. Robopedia: Leveraging Sensorpedia for Web-Enabled Robot Control

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Resseguie, David R

    There is a growing interest in building Internetscale sensor networks that integrate sensors from around the world into a single unified system. In contrast, robotics application development has primarily focused on building specialized systems. These specialized systems take scalability and reliability into consideration, but generally neglect exploring the key components required to build a large scale system. Integrating robotic applications with Internet-scale sensor networks will unify specialized robotics applications and provide answers to large scale implementation concerns. We focus on utilizing Internet-scale sensor network technology to construct a framework for unifying robotic systems. Our framework web-enables a surveillance robot smore » sensor observations and provides a webinterface to the robot s actuators. This lets robots seamlessly integrate into web applications. In addition, the framework eliminates most prerequisite robotics knowledge, allowing for the creation of general web-based robotics applications. The framework also provides mechanisms to create applications that can interface with any robot. Frameworks such as this one are key to solving large scale mobile robotics implementation problems. We provide an overview of previous Internetscale sensor networks, Sensorpedia (an ad-hoc Internet-scale sensor network), our framework for integrating robots with Sensorpedia, two applications which illustrate our frameworks ability to support general web-based robotic control, and offer experimental results that illustrate our framework s scalability, feasibility, and resource requirements.« less

  4. The Role of Forests in Regulating the River Flow Regime of Large Basins of the World

    NASA Astrophysics Data System (ADS)

    Salazar, J. F.; Villegas, J. C.; Mercado-Bettin, D. A.; Rodríguez, E.

    2016-12-01

    Many natural and social phenomena depend on river flow regimes that are being altered by global change. Understanding the mechanisms behind such alterations is crucial for predicting river flow regimes in a changing environment. Here we explore potential linkages between the presence of forests and the capacity of river basins for regulating river flows. Regulation is defined here as the capacity of river basins to attenuate the amplitude of the river flow regime, that is to reduce the difference between high and low flows. We first use scaling theory to show how scaling properties of observed river flows can be used to classify river basins as regulated or unregulated. This parsimonious classification is based on a physical interpretation of the scaling properties (particularly the scaling exponents) that is novel (most previous studies have focused on the interpretation of the scaling exponents for floods only), and widely-applicable to different basins (the only assumption is that river flows in a given river basin exhibit scaling properties through well-known power laws). Then we show how this scaling framework can be used to explore global-change-induced temporal variations in the regulation capacity of river basins. Finally, we propose a conceptual hypothesis (the "Forest reservoir concept") to explain how large-scale forests can exert important effects on the long-term water balance partitioning and regulation capacity of large basins of the world. Our quantitative results are based on data analysis (river flows and land cover features) from 22 large basins of the world, with emphasis in the Amazon river and its main tributaries. Collectively, our findings support the hypothesis that forest cover enhances the capacity of large river basins to maintain relatively high mean river flows, as well as to regulate (ameliorate) extreme river flows. Advancing towards this quantitative understanding of the relation between forest cover and river flow regimes is crucial for water management- and land cover-related decisions.

  5. The Role of Forests in Regulating the River Flow Regime of Large Basins of the World

    NASA Astrophysics Data System (ADS)

    Salazar, J. F.; Villegas, J. C.; Mercado-Bettin, D. A.; Rodríguez, E.

    2017-12-01

    Many natural and social phenomena depend on river flow regimes that are being altered by global change. Understanding the mechanisms behind such alterations is crucial for predicting river flow regimes in a changing environment. Here we explore potential linkages between the presence of forests and the capacity of river basins for regulating river flows. Regulation is defined here as the capacity of river basins to attenuate the amplitude of the river flow regime, that is to reduce the difference between high and low flows. We first use scaling theory to show how scaling properties of observed river flows can be used to classify river basins as regulated or unregulated. This parsimonious classification is based on a physical interpretation of the scaling properties (particularly the scaling exponents) that is novel (most previous studies have focused on the interpretation of the scaling exponents for floods only), and widely-applicable to different basins (the only assumption is that river flows in a given river basin exhibit scaling properties through well-known power laws). Then we show how this scaling framework can be used to explore global-change-induced temporal variations in the regulation capacity of river basins. Finally, we propose a conceptual hypothesis (the "Forest reservoir concept") to explain how large-scale forests can exert important effects on the long-term water balance partitioning and regulation capacity of large basins of the world. Our quantitative results are based on data analysis (river flows and land cover features) from 22 large basins of the world, with emphasis in the Amazon river and its main tributaries. Collectively, our findings support the hypothesis that forest cover enhances the capacity of large river basins to maintain relatively high mean river flows, as well as to regulate (ameliorate) extreme river flows. Advancing towards this quantitative understanding of the relation between forest cover and river flow regimes is crucial for water management- and land cover-related decisions.

  6. Large-scale structures in turbulent Couette flow

    NASA Astrophysics Data System (ADS)

    Kim, Jung Hoon; Lee, Jae Hwa

    2016-11-01

    Direct numerical simulation of fully developed turbulent Couette flow is performed with a large computational domain in the streamwise and spanwise directions (40 πh and 6 πh) to investigate streamwise-scale growth mechanism of the streamwise velocity fluctuating structures in the core region, where h is the channel half height. It is shown that long streamwise-scale structures (> 3 h) are highly energetic and they contribute to more than 80% of the turbulent kinetic energy and Reynolds shear stress, compared to previous studies in canonical Poiseuille flows. Instantaneous and statistical analysis show that negative-u' structures on the bottom wall in the Couette flow continuously grow in the streamwise direction due to mean shear, and they penetrate to the opposite moving wall. The geometric center of the log layer is observed in the centerline with a dominant outer peak in streamwise spectrum, and the maximum streamwise extent for structure is found in the centerline, similar to previous observation in turbulent Poiseuille flows at high Reynolds number. Further inspection of time-evolving instantaneous fields clearly exhibits that adjacent long structures combine to form a longer structure in the centerline. This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2014R1A1A2057031).

  7. Scaling and memory in volatility return intervals in financial markets

    PubMed Central

    Yamasaki, Kazuko; Muchnik, Lev; Havlin, Shlomo; Bunde, Armin; Stanley, H. Eugene

    2005-01-01

    For both stock and currency markets, we study the return intervals τ between the daily volatilities of the price changes that are above a certain threshold q. We find that the distribution function Pq(τ) scales with the mean return interval \\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\setlength{\\oddsidemargin}{-69pt} \\begin{document} \\begin{equation*}{\\bar {{\\tau}}}\\end{equation*}\\end{document} as \\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\setlength{\\oddsidemargin}{-69pt} \\begin{document} \\begin{equation*}P_{q}({\\tau})={\\bar {{\\tau}}}^{-1}f({\\tau}/{\\bar {{\\tau}}})\\end{equation*}\\end{document}. The scaling function f(x) is similar in form for all seven stocks and for all seven currency databases analyzed, and f(x) is consistent with a power-law form, f(x) ∼ x-γ with γ ≈ 2. We also quantify how the conditional distribution Pq(τ|τ0) depends on the previous return interval τ0 and find that small (or large) return intervals are more likely to be followed by small (or large) return intervals. This “clustering” of the volatility return intervals is a previously unrecognized phenomenon that we relate to the long-term correlations known to be present in the volatility. PMID:15980152

  8. Scaling and memory in volatility return intervals in financial markets

    NASA Astrophysics Data System (ADS)

    Yamasaki, Kazuko; Muchnik, Lev; Havlin, Shlomo; Bunde, Armin; Stanley, H. Eugene

    2005-06-01

    For both stock and currency markets, we study the return intervals τ between the daily volatilities of the price changes that are above a certain threshold q. We find that the distribution function Pq(τ) scales with the mean return interval [Formula] as [Formula]. The scaling function f(x) is similar in form for all seven stocks and for all seven currency databases analyzed, and f(x) is consistent with a power-law form, f(x) ˜ x-γ with γ ≈ 2. We also quantify how the conditional distribution Pq(τ|τ0) depends on the previous return interval τ0 and find that small (or large) return intervals are more likely to be followed by small (or large) return intervals. This “clustering” of the volatility return intervals is a previously unrecognized phenomenon that we relate to the long-term correlations known to be present in the volatility. Author contributions: S.H. and H.E.S. designed research; K.Y., L.M., S.H., and H.E.S. performed research; A.B. contributed new reagents/analytic tools; A.B. analyzed data; and S.H. wrote the paper.Abbreviations: pdf, probability density function; S&P 500, Standard and Poor's 500 Index; USD, U.S. dollar; JPY, Japanese yen; SEK, Swedish krona.

  9. Optimization and large scale computation of an entropy-based moment closure

    NASA Astrophysics Data System (ADS)

    Kristopher Garrett, C.; Hauck, Cory; Hill, Judith

    2015-12-01

    We present computational advances and results in the implementation of an entropy-based moment closure, MN, in the context of linear kinetic equations, with an emphasis on heterogeneous and large-scale computing platforms. Entropy-based closures are known in several cases to yield more accurate results than closures based on standard spectral approximations, such as PN, but the computational cost is generally much higher and often prohibitive. Several optimizations are introduced to improve the performance of entropy-based algorithms over previous implementations. These optimizations include the use of GPU acceleration and the exploitation of the mathematical properties of spherical harmonics, which are used as test functions in the moment formulation. To test the emerging high-performance computing paradigm of communication bound simulations, we present timing results at the largest computational scales currently available. These results show, in particular, load balancing issues in scaling the MN algorithm that do not appear for the PN algorithm. We also observe that in weak scaling tests, the ratio in time to solution of MN to PN decreases.

  10. Optimization and large scale computation of an entropy-based moment closure

    DOE PAGES

    Hauck, Cory D.; Hill, Judith C.; Garrett, C. Kristopher

    2015-09-10

    We present computational advances and results in the implementation of an entropy-based moment closure, M N, in the context of linear kinetic equations, with an emphasis on heterogeneous and large-scale computing platforms. Entropy-based closures are known in several cases to yield more accurate results than closures based on standard spectral approximations, such as P N, but the computational cost is generally much higher and often prohibitive. Several optimizations are introduced to improve the performance of entropy-based algorithms over previous implementations. These optimizations include the use of GPU acceleration and the exploitation of the mathematical properties of spherical harmonics, which aremore » used as test functions in the moment formulation. To test the emerging high-performance computing paradigm of communication bound simulations, we present timing results at the largest computational scales currently available. Lastly, these results show, in particular, load balancing issues in scaling the M N algorithm that do not appear for the P N algorithm. We also observe that in weak scaling tests, the ratio in time to solution of M N to P N decreases.« less

  11. What Types of Pornography Do People Find Arousing and Do They Cluster? Assessing Types and Categories of Pornography in a Large-Scale Online Sample.

    PubMed

    Hald, Gert Martin; Štulhofer, Aleksandar

    2016-09-01

    Previous research on exposure to different types of pornography has primarily relied on analyses of millions of search terms and histories or on user exposure patterns within a given time period rather than the self-reported frequency of consumption. Further, previous research has almost exclusively relied on theoretical or ad hoc overarching categorizations of different types of pornography, when investigating patterns of pornography exposure, rather than latent structure analyses of these exposure patterns. In contrast, using a large sample of 18- to 40-year-old heterosexual and nonheterosexual Croatian men and women, this study investigated the self-reported frequency of using 27 different types of pornography and statistically explored their latent structures. The results showed substantial differences in consumption patterns across gender and sexual orientation. However, latent structure analyses of the 27 different types of pornography assessed suggested that although several categories of consumption were gender and sexual orientation specific, common categories across the different types of pornography could be established. Based on this finding, a five-item scale was proposed to indicate the use of nonmainstream (paraphilic) pornographic content, as this type of pornography has often been targeted in previous research. To the best of our knowledge, no similar measurement tool has been proposed before.

  12. Evaluation of Alternative Altitude Scaling Methods for Thermal Ice Protection System in NASA Icing Research Tunnel

    NASA Technical Reports Server (NTRS)

    Lee, Sam; Addy, Harold; Broeren, Andy P.; Orchard, David M.

    2017-01-01

    A test was conducted at NASA Icing Research Tunnel to evaluate altitude scaling methods for thermal ice protection system. Two scaling methods based on Weber number were compared against a method based on the Reynolds number. The results generally agreed with the previous set of tests conducted in NRCC Altitude Icing Wind Tunnel. The Weber number based scaling methods resulted in smaller runback ice mass than the Reynolds number based scaling method. The ice accretions from the Weber number based scaling method also formed farther upstream. However there were large differences in the accreted ice mass between the two Weber number based scaling methods. The difference became greater when the speed was increased. This indicated that there may be some Reynolds number effects that isnt fully accounted for and warrants further study.

  13. Geologic map of Chickasaw National Recreation Area, Murray County, Oklahoma

    USGS Publications Warehouse

    Blome, Charles D.; Lidke, David J.; Wahl, Ronald R.; Golab, James A.

    2013-01-01

    This 1:24,000-scale geologic map is a compilation of previous geologic maps and new geologic mapping of areas in and around Chickasaw National Recreation Area. The geologic map includes revisions of numerous unit contacts and faults and a number of previously “undifferentiated” rock units were subdivided in some areas. Numerous circular-shaped hills in and around Chickasaw National Recreation Area are probably the result of karst-related collapse and may represent the erosional remnants of large, exhumed sinkholes. Geospatial registration of existing, smaller scale (1:72,000- and 1:100,000-scale) geologic maps of the area and construction of an accurate Geographic Information System (GIS) database preceded 2 years of fieldwork wherein previously mapped geology (unit contacts and faults) was verified and new geologic mapping was carried out. The geologic map of Chickasaw National Recreation Area and this pamphlet include information pertaining to how the geologic units and structural features in the map area relate to the formation of the northern Arbuckle Mountains and its Arbuckle-Simpson aquifer. The development of an accurate geospatial GIS database and the use of a handheld computer in the field greatly increased both the accuracy and efficiency in producing the 1:24,000-scale geologic map.

  14. An extensive spectroscopic time series of three Wolf-Rayet stars - I. The lifetime of large-scale structures in the wind of WR 134

    NASA Astrophysics Data System (ADS)

    Aldoretta, E. J.; St-Louis, N.; Richardson, N. D.; Moffat, A. F. J.; Eversberg, T.; Hill, G. M.; Shenar, T.; Artigau, É.; Gauza, B.; Knapen, J. H.; Kubát, J.; Kubátová, B.; Maltais-Tariant, R.; Muñoz, M.; Pablo, H.; Ramiaramanantsoa, T.; Richard-Laferrière, A.; Sablowski, D. P.; Simón-Díaz, S.; St-Jean, L.; Bolduan, F.; Dias, F. M.; Dubreuil, P.; Fuchs, D.; Garrel, T.; Grutzeck, G.; Hunger, T.; Küsters, D.; Langenbrink, M.; Leadbeater, R.; Li, D.; Lopez, A.; Mauclaire, B.; Moldenhawer, T.; Potter, M.; dos Santos, E. M.; Schanne, L.; Schmidt, J.; Sieske, H.; Strachan, J.; Stinner, E.; Stinner, P.; Stober, B.; Strandbaek, K.; Syder, T.; Verilhac, D.; Waldschläger, U.; Weiss, D.; Wendt, A.

    2016-08-01

    During the summer of 2013, a 4-month spectroscopic campaign took place to observe the variabilities in three Wolf-Rayet stars. The spectroscopic data have been analysed for WR 134 (WN6b), to better understand its behaviour and long-term periodicity, which we interpret as arising from corotating interaction regions (CIRs) in the wind. By analysing the variability of the He II λ5411 emission line, the previously identified period was refined to P = 2.255 ± 0.008 (s.d.) d. The coherency time of the variability, which we associate with the lifetime of the CIRs in the wind, was deduced to be 40 ± 6 d, or ˜18 cycles, by cross-correlating the variability patterns as a function of time. When comparing the phased observational grey-scale difference images with theoretical grey-scales previously calculated from models including CIRs in an optically thin stellar wind, we find that two CIRs were likely present. A separation in longitude of Δφ ≃ 90° was determined between the two CIRs and we suggest that the different maximum velocities that they reach indicate that they emerge from different latitudes. We have also been able to detect observational signatures of the CIRs in other spectral lines (C IV λλ5802,5812 and He I λ5876). Furthermore, a DAC was found to be present simultaneously with the CIR signatures detected in the He I λ5876 emission line which is consistent with the proposed geometry of the large-scale structures in the wind. Small-scale structures also show a presence in the wind, simultaneously with the larger scale structures, showing that they do in fact co-exist.

  15. Clustering on very small scales from a large sample of confirmed quasar pairs: does quasar clustering track from Mpc to kpc scales?

    NASA Astrophysics Data System (ADS)

    Eftekharzadeh, S.; Myers, A. D.; Hennawi, J. F.; Djorgovski, S. G.; Richards, G. T.; Mahabal, A. A.; Graham, M. J.

    2017-06-01

    We present the most precise estimate to date of the clustering of quasars on very small scales, based on a sample of 47 binary quasars with magnitudes of g < 20.85 and proper transverse separations of ˜25 h-1 kpc. Our sample of binary quasars, which is about six times larger than any previous spectroscopically confirmed sample on these scales, is targeted using a kernel density estimation (KDE) technique applied to Sloan Digital Sky Survey (SDSS) imaging over most of the SDSS area. Our sample is 'complete' in that all of the KDE target pairs with 17.0 ≲ R ≲ 36.2 h-1 kpc in our area of interest have been spectroscopically confirmed from a combination of previous surveys and our own long-slit observational campaign. We catalogue 230 candidate quasar pairs with angular separations of <8 arcsec, from which our binary quasars were identified. We determine the projected correlation function of quasars (\\bar{W}_p) in four bins of proper transverse scale over the range 17.0 ≲ R ≲ 36.2 h-1 kpc. The implied small-scale quasar clustering amplitude from the projected correlation function, integrated across our entire redshift range, is A = 24.1 ± 3.6 at ˜26.6 h-1 kpc. Our sample is the first spectroscopically confirmed sample of quasar pairs that is sufficiently large to study how quasar clustering evolves with redshift at ˜25 h-1 kpc. We find that empirical descriptions of how quasar clustering evolves with redshift at ˜25 h-1 Mpc also adequately describe the evolution of quasar clustering at ˜25 h-1 kpc.

  16. Large-scale structure perturbation theory without losing stream crossing

    NASA Astrophysics Data System (ADS)

    McDonald, Patrick; Vlah, Zvonimir

    2018-01-01

    We suggest an approach to perturbative calculations of large-scale clustering in the Universe that includes from the start the stream crossing (multiple velocities for mass elements at a single position) that is lost in traditional calculations. Starting from a functional integral over displacement, the perturbative series expansion is in deviations from (truncated) Zel'dovich evolution, with terms that can be computed exactly even for stream-crossed displacements. We evaluate the one-loop formulas for displacement and density power spectra numerically in 1D, finding dramatic improvement in agreement with N-body simulations compared to the Zel'dovich power spectrum (which is exact in 1D up to stream crossing). Beyond 1D, our approach could represent an improvement over previous expansions even aside from the inclusion of stream crossing, but we have not investigated this numerically. In the process we show how to achieve effective-theory-like regulation of small-scale fluctuations without free parameters.

  17. Measures for a transdimensional multiverse

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schwartz-Perlov, Delia; Vilenkin, Alexander, E-mail: dperlov@cosmos.phy.tufts.edu, E-mail: vilenkin@cosmos.phy.tufts.edu

    2010-06-01

    The multiverse/landscape paradigm that has emerged from eternal inflation and string theory, describes a large-scale multiverse populated by ''pocket universes'' which come in a huge variety of different types, including different dimensionalities. In order to make predictions in the multiverse, we need a probability measure. In (3+1)d landscapes, the scale factor cutoff measure has been previously shown to have a number of attractive properties. Here we consider possible generalizations of this measure to a transdimensional multiverse. We find that a straightforward extension of scale factor cutoff to the transdimensional case gives a measure that strongly disfavors large amounts of slow-rollmore » inflation and predicts low values for the density parameter Ω, in conflict with observations. A suitable generalization, which retains all the good properties of the original measure, is the ''volume factor'' cutoff, which regularizes the infinite spacetime volume using cutoff surfaces of constant volume expansion factor.« less

  18. Volatility return intervals analysis of the Japanese market

    NASA Astrophysics Data System (ADS)

    Jung, W.-S.; Wang, F. Z.; Havlin, S.; Kaizoji, T.; Moon, H.-T.; Stanley, H. E.

    2008-03-01

    We investigate scaling and memory effects in return intervals between price volatilities above a certain threshold q for the Japanese stock market using daily and intraday data sets. We find that the distribution of return intervals can be approximated by a scaling function that depends only on the ratio between the return interval τ and its mean <τ>. We also find memory effects such that a large (or small) return interval follows a large (or small) interval by investigating the conditional distribution and mean return interval. The results are similar to previous studies of other markets and indicate that similar statistical features appear in different financial markets. We also compare our results between the period before and after the big crash at the end of 1989. We find that scaling and memory effects of the return intervals show similar features although the statistical properties of the returns are different.

  19. A Census of Large-scale (≥10 PC), Velocity-coherent, Dense Filaments in the Northern Galactic Plane: Automated Identification Using Minimum Spanning Tree

    NASA Astrophysics Data System (ADS)

    Wang, Ke; Testi, Leonardo; Burkert, Andreas; Walmsley, C. Malcolm; Beuther, Henrik; Henning, Thomas

    2016-09-01

    Large-scale gaseous filaments with lengths up to the order of 100 pc are on the upper end of the filamentary hierarchy of the Galactic interstellar medium (ISM). Their association with respect to the Galactic structure and their role in Galactic star formation are of great interest from both an observational and theoretical point of view. Previous “by-eye” searches, combined together, have started to uncover the Galactic distribution of large filaments, yet inherent bias and small sample size limit conclusive statistical results from being drawn. Here, we present (1) a new, automated method for identifying large-scale velocity-coherent dense filaments, and (2) the first statistics and the Galactic distribution of these filaments. We use a customized minimum spanning tree algorithm to identify filaments by connecting voxels in the position-position-velocity space, using the Bolocam Galactic Plane Survey spectroscopic catalog. In the range of 7\\buildrel{\\circ}\\over{.} 5≤slant l≤slant 194^\\circ , we have identified 54 large-scale filaments and derived mass (˜ {10}3{--}{10}5 {M}⊙ ), length (10-276 pc), linear mass density (54-8625 {M}⊙ pc-1), aspect ratio, linearity, velocity gradient, temperature, fragmentation, Galactic location, and orientation angle. The filaments concentrate along major spiral arms. They are widely distributed across the Galactic disk, with 50% located within ±20 pc from the Galactic mid-plane and 27% run in the center of spiral arms. An order of 1% of the molecular ISM is confined in large filaments. Massive star formation is more favorable in large filaments compared to elsewhere. This is the first comprehensive catalog of large filaments that can be useful for a quantitative comparison with spiral structures and numerical simulations.

  20. The effects of streamwise concave curvature on turbulent boundary layer structure

    NASA Astrophysics Data System (ADS)

    Jeans, A. H.; Johnston, J. P.

    1982-06-01

    Concave curvature has a relatively large, unpredictable effect on turbulent boundary layers. Some, but not all previous studies suggest that a large-scale, stationary array of counter-rotating vortices exists within the turbulent boundary layer on a concave wall. The objective of the present study was to obtain a qualitative model of the flow field in order to increase our understanding of the underlying physics. A large free-surface water channel was constructed in order to perform a visual study of the flow. Streamwise components of mean velocity and turbulence intensity were measured using a hot film anemometer. The upstream boundary was spanwise uniform with a momentum thickness to radius of curvature of 0.05. Compared to flat wall flow, large-scale, randomly distributed sweeps and ejections were seen in the boundary layer on the concave wall. The sweeps appear to suppress the normal mechanism for turbulence production near the wall by inhibiting the bursting process. The ejections appear to enhance turbulence production in the outer layers as the low speed fluid convected from regions near the wall interacts with the higher speed fluid farther out. The large-scale structures did not occur at fixed spanwise locations, and could not be called roll cells or vortices.

  1. Extracting Compositional Variation from THEMIS Data for Features with Large Topography on Mars Via Atmospheric Equalization

    NASA Technical Reports Server (NTRS)

    Anderson, F. S.; Drake, J. S.; Hamilton, V. E.

    2005-01-01

    We have developed a means of equalizing the atmospheric signature in Mars Odyssey Thermal Emission Imaging System (THEMIS) infrared data over regions with large topography such as the Valles Marineris (VM). This equalization allows for the analysis of compositional variations in regions that previously have been difficult to study because of the large differences in atmospheric path length that result from large changes in surface elevation. Specifically, our motivation for this study is to examine deposits that are small at the scales observable by the Thermal Emission Spectrometer (TES) onboard Mars Global Surveyor, but which are more readily resolved with THEMIS.

  2. The Future of Stellar Populations Studies in the Milky Way and the Local Group

    NASA Astrophysics Data System (ADS)

    Majewski, Steven R.

    2010-04-01

    The last decade has seen enormous progress in understanding the structure of the Milky Way and neighboring galaxies via the production of large-scale digital surveys of the sky like 2MASS and SDSS, as well as specialized, counterpart imaging surveys of other Local Group systems. Apart from providing snaphots of galaxy structure, these “cartographic” surveys lend insights into the formation and evolution of galaxies when supplemented with additional data (e.g., spectroscopy, astrometry) and when referenced to theoretical models and simulations of galaxy evolution. These increasingly sophisticated simulations are making ever more specific predictions about the detailed chemistry and dynamics of stellar populations in galaxies. To fully exploit, test and constrain these theoretical ventures demands similar commitments of observational effort as has been plied into the previous imaging surveys to fill out other dimensions of parameter space with statistically significant intensity. Fortunately the future of large-scale stellar population studies is bright with a number of grand projects on the horizon that collectively will contribute a breathtaking volume of information on individual stars in Local Group galaxies. These projects include: (1) additional imaging surveys, such as Pan-STARRS, SkyMapper and LSST, which, apart from providing deep, multicolor imaging, yield time series data useful for revealing variable stars (including critical standard candles, like RR Lyrae variables) and creating large-scale, deep proper motion catalogs; (2) higher accuracy, space-based astrometric missions, such as Gaia and SIM-Lite, which stand to provide critical, high precision dynamical data on stars in the Milky Way and its satellites; and (3) large-scale spectroscopic surveys provided by RAVE, APOGEE, HERMES, LAMOST, and the Gaia spectrometer, which will yield not only enormous numbers of stellar radial velocities, but extremely comprehensive views of the chemistry of stellar populations. Meanwhile, previously dust-obscured regions of the Milky Way will continue to be systematically exposed via large infrared surveys underway or on the way, such as the various GLIMPSE surveys from Spitzer's IRAC instrument, UKIDSS, APOGEE, JASMINE and WISE.

  3. New probes of Cosmic Microwave Background large-scale anomalies

    NASA Astrophysics Data System (ADS)

    Aiola, Simone

    Fifty years of Cosmic Microwave Background (CMB) data played a crucial role in constraining the parameters of the LambdaCDM model, where Dark Energy, Dark Matter, and Inflation are the three most important pillars not yet understood. Inflation prescribes an isotropic universe on large scales, and it generates spatially-correlated density fluctuations over the whole Hubble volume. CMB temperature fluctuations on scales bigger than a degree in the sky, affected by modes on super-horizon scale at the time of recombination, are a clean snapshot of the universe after inflation. In addition, the accelerated expansion of the universe, driven by Dark Energy, leaves a hardly detectable imprint in the large-scale temperature sky at late times. Such fundamental predictions have been tested with current CMB data and found to be in tension with what we expect from our simple LambdaCDM model. Is this tension just a random fluke or a fundamental issue with the present model? In this thesis, we present a new framework to probe the lack of large-scale correlations in the temperature sky using CMB polarization data. Our analysis shows that if a suppression in the CMB polarization correlations is detected, it will provide compelling evidence for new physics on super-horizon scale. To further analyze the statistical properties of the CMB temperature sky, we constrain the degree of statistical anisotropy of the CMB in the context of the observed large-scale dipole power asymmetry. We find evidence for a scale-dependent dipolar modulation at 2.5sigma. To isolate late-time signals from the primordial ones, we test the anomalously high Integrated Sachs-Wolfe effect signal generated by superstructures in the universe. We find that the detected signal is in tension with the expectations from LambdaCDM at the 2.5sigma level, which is somewhat smaller than what has been previously argued. To conclude, we describe the current status of CMB observations on small scales, highlighting the tensions between Planck, WMAP, and SPT temperature data and how the upcoming data release of the ACTpol experiment will contribute to this matter. We provide a description of the current status of the data-analysis pipeline and discuss its ability to recover large-scale modes.

  4. The implications of the COBE diffuse microwave radiation results for cosmic strings

    NASA Technical Reports Server (NTRS)

    Bennett, David P.; Stebbins, Albert; Bouchet, Francois R.

    1992-01-01

    We compare the anisotropies in the cosmic microwave background radiation measured by the COBE experiment to those predicted by cosmic string theories. We use an analytic model for the Delta T/T power spectrum that is based on our previous numerical simulations of strings, under the assumption that cosmic strings are the sole source of the measured anisotropy. This implies a value for the string mass per unit length of 1.5 +/- 0.5 x 10 exp -6 C-squared/G. This is within the range of values required for cosmic strings to successfully seed the formation of large-scale structures in the universe. These results clearly encourage further studies of Delta T/T and large-scale structure in the cosmic string model.

  5. Longitudinal aerodynamic characteristics of a large scale model with a swept wing and augmented jet flap in ground effect

    NASA Technical Reports Server (NTRS)

    Falarski, M. D.; Koenig, D. G.

    1972-01-01

    The investigation of the in-ground-effect, longitudinal aerodynamic characteristics of a large scale swept augmentor wing model is presented, using 40 x 80 ft wind tunnel. The investigation was conducted at three ground heights; h/c equals 2.01, 1.61, and 1.34. The induced effect of underwing nacelles, was studied with two powered nacelle configurations. One configuration used four JT-15D turbofans while the other used two J-85 turbojet engines. Two conical nozzles on each J-85 were used to deflect the thrust at angles from 0 to 120 deg. Tests were also performed without nacelles to allow comparison with previous data from ground effect.

  6. Random number generators for large-scale parallel Monte Carlo simulations on FPGA

    NASA Astrophysics Data System (ADS)

    Lin, Y.; Wang, F.; Liu, B.

    2018-05-01

    Through parallelization, field programmable gate array (FPGA) can achieve unprecedented speeds in large-scale parallel Monte Carlo (LPMC) simulations. FPGA presents both new constraints and new opportunities for the implementations of random number generators (RNGs), which are key elements of any Monte Carlo (MC) simulation system. Using empirical and application based tests, this study evaluates all of the four RNGs used in previous FPGA based MC studies and newly proposed FPGA implementations for two well-known high-quality RNGs that are suitable for LPMC studies on FPGA. One of the newly proposed FPGA implementations: a parallel version of additive lagged Fibonacci generator (Parallel ALFG) is found to be the best among the evaluated RNGs in fulfilling the needs of LPMC simulations on FPGA.

  7. Large-scale semidefinite programming for many-electron quantum mechanics.

    PubMed

    Mazziotti, David A

    2011-02-25

    The energy of a many-electron quantum system can be approximated by a constrained optimization of the two-electron reduced density matrix (2-RDM) that is solvable in polynomial time by semidefinite programming (SDP). Here we develop a SDP method for computing strongly correlated 2-RDMs that is 10-20 times faster than previous methods [D. A. Mazziotti, Phys. Rev. Lett. 93, 213001 (2004)]. We illustrate with (i) the dissociation of N(2) and (ii) the metal-to-insulator transition of H(50). For H(50) the SDP problem has 9.4×10(6) variables. This advance also expands the feasibility of large-scale applications in quantum information, control, statistics, and economics. © 2011 American Physical Society

  8. Large-Scale Semidefinite Programming for Many-Electron Quantum Mechanics

    NASA Astrophysics Data System (ADS)

    Mazziotti, David A.

    2011-02-01

    The energy of a many-electron quantum system can be approximated by a constrained optimization of the two-electron reduced density matrix (2-RDM) that is solvable in polynomial time by semidefinite programming (SDP). Here we develop a SDP method for computing strongly correlated 2-RDMs that is 10-20 times faster than previous methods [D. A. Mazziotti, Phys. Rev. Lett. 93, 213001 (2004)PRLTAO0031-900710.1103/PhysRevLett.93.213001]. We illustrate with (i) the dissociation of N2 and (ii) the metal-to-insulator transition of H50. For H50 the SDP problem has 9.4×106 variables. This advance also expands the feasibility of large-scale applications in quantum information, control, statistics, and economics.

  9. Efficient tiled calculation of over-10-gigapixel holograms using ray-wavefront conversion.

    PubMed

    Igarashi, Shunsuke; Nakamura, Tomoya; Matsushima, Kyoji; Yamaguchi, Masahiro

    2018-04-16

    In the calculation of large-scale computer-generated holograms, an approach called "tiling," which divides the hologram plane into small rectangles, is often employed due to limitations on computational memory. However, the total amount of computational complexity severely increases with the number of divisions. In this paper, we propose an efficient method for calculating tiled large-scale holograms using ray-wavefront conversion. In experiments, the effectiveness of the proposed method was verified by comparing its calculation cost with that using the previous method. Additionally, a hologram of 128K × 128K pixels was calculated and fabricated by a laser-lithography system, and a high-quality 105 mm × 105 mm 3D image including complicated reflection and translucency was optically reconstructed.

  10. Parallel Visualization of Large-Scale Aerodynamics Calculations: A Case Study on the Cray T3E

    NASA Technical Reports Server (NTRS)

    Ma, Kwan-Liu; Crockett, Thomas W.

    1999-01-01

    This paper reports the performance of a parallel volume rendering algorithm for visualizing a large-scale, unstructured-grid dataset produced by a three-dimensional aerodynamics simulation. This dataset, containing over 18 million tetrahedra, allows us to extend our performance results to a problem which is more than 30 times larger than the one we examined previously. This high resolution dataset also allows us to see fine, three-dimensional features in the flow field. All our tests were performed on the Silicon Graphics Inc. (SGI)/Cray T3E operated by NASA's Goddard Space Flight Center. Using 511 processors, a rendering rate of almost 9 million tetrahedra/second was achieved with a parallel overhead of 26%.

  11. Designing Large-Scale Multisite and Cluster-Randomized Studies of Professional Development

    ERIC Educational Resources Information Center

    Kelcey, Ben; Spybrook, Jessaca; Phelps, Geoffrey; Jones, Nathan; Zhang, Jiaqi

    2017-01-01

    We develop a theoretical and empirical basis for the design of teacher professional development studies. We build on previous work by (a) developing estimates of intraclass correlation coefficients for teacher outcomes using two- and three-level data structures, (b) developing estimates of the variance explained by covariates, and (c) modifying…

  12. Large-scale confirmatory tests of a phytosanitary irradiation treatment against Sternochetus frigidus (F.) in Philippine mango

    USDA-ARS?s Scientific Manuscript database

    The mango pulp weevil, Sternochetus frigidus (F.) is an important quarantine pest preventing the export of mangoes from the Philippines to the United States and other countries. Previously, a radiation dose of 100 Gy was proposed for phytosanitary treatment of S. frigidus based on dose-response stud...

  13. Evaluating real-time Java for mission-critical large-scale embedded systems

    NASA Technical Reports Server (NTRS)

    Sharp, D. C.; Pla, E.; Luecke, K. R.; Hassan, R. J.

    2003-01-01

    This paper describes benchmarking results on an RT JVM. This paper extends previously published results by including additional tests, by being run on a recently available pre-release version of the first commercially supported RTSJ implementation, and by assessing results based on our experience with avionics systems in other languages.

  14. Is Game Behavior Related to Behavior in Any Other Situation?

    ERIC Educational Resources Information Center

    McTavish, Jeanne

    This paper begins by reviewing previous research concerning the external validity of mixed-motive games as models of international conflict, interpersonal behavior, and behavior in large-scale social dilemmas. Two further experiments are then described, both of which cast further doubt upon the usefulness of such games as models of any real-world…

  15. Updated generalized biomass equations for North American tree species

    Treesearch

    David C. Chojnacky; Linda S. Heath; Jennifer C. Jenkins

    2014-01-01

    Historically, tree biomass at large scales has been estimated by applying dimensional analysis techniques and field measurements such as diameter at breast height (dbh) in allometric regression equations. Equations often have been developed using differing methods and applied only to certain species or isolated areas. We previously had compiled and combined (in meta-...

  16. Data Management Practices and Perspectives of Atmospheric Scientists and Engineering Faculty

    ERIC Educational Resources Information Center

    Wiley, Christie; Mischo, William H.

    2016-01-01

    This article analyzes 21 in-depth interviews of engineering and atmospheric science faculty at the University of Illinois Urbana-Champaign (UIUC) to determine faculty data management practices and needs within the context of their research activities. A detailed literature review of previous large-scale and institutional surveys and interviews…

  17. Psychiatric Illness in a Cohort of Adults with Prader-Willi Syndrome

    ERIC Educational Resources Information Center

    Sinnema, Margje; Boer, Harm; Collin, Philippe; Maaskant, Marian A.; van Roozendaal, Kees E. P.; Schrander-Stumpel, Constance T. R. M.; Curfs, Leopold M. G.

    2011-01-01

    Previous studies have suggested an association between PWS and comorbid psychiatric illness. Data on prevalence rates of psychopathology is still scarce. This paper describes a large-scale, systematic study investigating the prevalence of psychiatric illness in a Dutch adult PWS cohort. One hundred and two individuals were screened for psychiatric…

  18. Identification of Student- and Teacher-Level Variables in Modeling Variation of Mathematics Achievement Data

    ERIC Educational Resources Information Center

    Tarr, James E.; Ross, Daniel J.; McNaught, Melissa D.; Chavez, Oscar; Grouws, Douglas A.; Reys, Robert E.; Sears, Ruthmae; Taylan, R. Didem

    2010-01-01

    The Comparing Options in Secondary Mathematics: Investigating Curriculum (COSMIC) project is a longitudinal study of student learning from two types of mathematics curricula: integrated and subject-specific. Previous large-scale research studies such as the National Assessment of Educational Progress (NAEP) indicate that numerous variables are…

  19. Effects of Child Maltreatment and Inherited Liability on Antisocial Development: An Official Records Study

    ERIC Educational Resources Information Center

    Jonson-Reid, Melissa; Presnall, Ned; Drake, Brett; Fox, Louis; Bierut, Laura; Reich, Wendy; Kane, Phyllis; Todd, Richard D.; Constantino, John N.

    2010-01-01

    Objective: Evidence is steadily accumulating that a preventable environmental hazard, child maltreatment, exerts causal influences on the development of long-standing patterns of antisocial behavior in humans. The relationship between child maltreatment and antisocial outcome, however, has never previously been tested in a large-scale study in…

  20. Depressive Symptoms Negate the Beneficial Effects of Physical Activity on Mortality Risk

    ERIC Educational Resources Information Center

    Lee, Pai-Lin

    2013-01-01

    The aim of this study is to: (1) compare the association between various levels of physical activity (PA) and mortality; and (2) examine the potential modifying effect of depressive symptoms on the PA-mortality associations. Previous large scale randomized studies rarely assess the association in conjunction with modifying effects of depressive…

  1. Visual Iconicity Across Sign Languages: Large-Scale Automated Video Analysis of Iconic Articulators and Locations

    PubMed Central

    Östling, Robert; Börstell, Carl; Courtaux, Servane

    2018-01-01

    We use automatic processing of 120,000 sign videos in 31 different sign languages to show a cross-linguistic pattern for two types of iconic form–meaning relationships in the visual modality. First, we demonstrate that the degree of inherent plurality of concepts, based on individual ratings by non-signers, strongly correlates with the number of hands used in the sign forms encoding the same concepts across sign languages. Second, we show that certain concepts are iconically articulated around specific parts of the body, as predicted by the associational intuitions by non-signers. The implications of our results are both theoretical and methodological. With regard to theoretical implications, we corroborate previous research by demonstrating and quantifying, using a much larger material than previously available, the iconic nature of languages in the visual modality. As for the methodological implications, we show how automatic methods are, in fact, useful for performing large-scale analysis of sign language data, to a high level of accuracy, as indicated by our manual error analysis. PMID:29867684

  2. Evidence and AIDS activism: HIV scale-up and the contemporary politics of knowledge in global public health

    PubMed Central

    Colvin, Christopher J.

    2014-01-01

    The HIV epidemic is widely recognised as having prompted one of the most remarkable intersections ever of illness, science and activism. The production, circulation, use and evaluation of empirical scientific ‘evidence’ played a central part in activists’ engagement with AIDS science. Previous activist engagement with evidence focused on the social and biomedical responses to HIV in the global North as well as challenges around ensuring antiretroviral treatment (ART) was available in the global South. More recently, however, with the roll-out and scale-up of large public-sector ART programmes and new multi-dimensional prevention efforts, the relationships between evidence and activism have been changing. Scale-up of these large-scale treatment and prevention programmes represents an exciting new opportunity while bringing with it a host of new challenges. This paper examines what new forms of evidence and activism will be required to address the challenges of the scaling-up era of HIV treatment and prevention. It reviews some recent controversies around evidence and HIV scale-up and describes the different forms of evidence and activist strategies that will be necessary for a robust response to these new challenges. PMID:24498918

  3. Multi-scale properties of large eddy simulations: correlations between resolved-scale velocity-field increments and subgrid-scale quantities

    NASA Astrophysics Data System (ADS)

    Linkmann, Moritz; Buzzicotti, Michele; Biferale, Luca

    2018-06-01

    We provide analytical and numerical results concerning multi-scale correlations between the resolved velocity field and the subgrid-scale (SGS) stress-tensor in large eddy simulations (LES). Following previous studies for Navier-Stokes equations, we derive the exact hierarchy of LES equations governing the spatio-temporal evolution of velocity structure functions of any order. The aim is to assess the influence of the subgrid model on the inertial range intermittency. We provide a series of predictions, within the multifractal theory, for the scaling of correlation involving the SGS stress and we compare them against numerical results from high-resolution Smagorinsky LES and from a-priori filtered data generated from direct numerical simulations (DNS). We find that LES data generally agree very well with filtered DNS results and with the multifractal prediction for all leading terms in the balance equations. Discrepancies are measured for some of the sub-leading terms involving cross-correlation between resolved velocity increments and the SGS tensor or the SGS energy transfer, suggesting that there must be room to improve the SGS modelisation to further extend the inertial range properties for any fixed LES resolution.

  4. Large-scale hydrological modeling for calculating water stress indices: implications of improved spatiotemporal resolution, surface-groundwater differentiation, and uncertainty characterization.

    PubMed

    Scherer, Laura; Venkatesh, Aranya; Karuppiah, Ramkumar; Pfister, Stephan

    2015-04-21

    Physical water scarcities can be described by water stress indices. These are often determined at an annual scale and a watershed level; however, such scales mask seasonal fluctuations and spatial heterogeneity within a watershed. In order to account for this level of detail, first and foremost, water availability estimates must be improved and refined. State-of-the-art global hydrological models such as WaterGAP and UNH/GRDC have previously been unable to reliably reflect water availability at the subbasin scale. In this study, the Soil and Water Assessment Tool (SWAT) was tested as an alternative to global models, using the case study of the Mississippi watershed. While SWAT clearly outperformed the global models at the scale of a large watershed, it was judged to be unsuitable for global scale simulations due to the high calibration efforts required. The results obtained in this study show that global assessments miss out on key aspects related to upstream/downstream relations and monthly fluctuations, which are important both for the characterization of water scarcity in the Mississippi watershed and for water footprints. Especially in arid regions, where scarcity is high, these models provide unsatisfying results.

  5. Capturing remote mixing due to internal tides using multi-scale modeling tool: SOMAR-LES

    NASA Astrophysics Data System (ADS)

    Santilli, Edward; Chalamalla, Vamsi; Scotti, Alberto; Sarkar, Sutanu

    2016-11-01

    Internal tides that are generated during the interaction of an oscillating barotropic tide with the bottom bathymetry dissipate only a fraction of their energy near the generation region. The rest is radiated away in the form of low- high-mode internal tides. These internal tides dissipate energy at remote locations when they interact with the upper ocean pycnocline, continental slope, and large scale eddies. Capturing the wide range of length and time scales involved during the life-cycle of internal tides is computationally very expensive. A recently developed multi-scale modeling tool called SOMAR-LES combines the adaptive grid refinement features of SOMAR with the turbulence modeling features of a Large Eddy Simulation (LES) to capture multi-scale processes at a reduced computational cost. Numerical simulations of internal tide generation at idealized bottom bathymetries are performed to demonstrate this multi-scale modeling technique. Although each of the remote mixing phenomena have been considered independently in previous studies, this work aims to capture remote mixing processes during the life cycle of an internal tide in more realistic settings, by allowing multi-level (coarse and fine) grids to co-exist and exchange information during the time stepping process.

  6. Population Vulnerability to Biannual Cholera Outbreaks and Associated Macro-Scale Drivers in the Bengal Delta

    PubMed Central

    Akanda, Ali Shafqat; Jutla, Antarpreet S.; Gute, David M.; Sack, R. Bradley; Alam, Munirul; Huq, Anwar; Colwell, Rita R.; Islam, Shafiqul

    2013-01-01

    The highly populated floodplains of the Bengal Delta have a long history of endemic and epidemic cholera outbreaks, both coastal and inland. Previous studies have not addressed the spatio-temporal dynamics of population vulnerability related to the influence of underlying large-scale processes. We analyzed spatial and temporal variability of cholera incidence across six surveillance sites in the Bengal Delta and their association with regional hydroclimatic and environmental drivers. More specifically, we use salinity and flood inundation modeling across the vulnerable districts of Bangladesh to test earlier proposed hypotheses on the role of these environmental variables. Our results show strong influence of seasonal and interannual variability in estuarine salinity on spring outbreaks and inland flooding on fall outbreaks. A large segment of the population in the Bengal Delta floodplains remain vulnerable to these biannual cholera transmission mechanisms that provide ecologic and environmental conditions for outbreaks over large geographic regions. PMID:24019441

  7. Large-scale two-photon imaging revealed super-sparse population codes in the V1 superficial layer of awake monkeys.

    PubMed

    Tang, Shiming; Zhang, Yimeng; Li, Zhihao; Li, Ming; Liu, Fang; Jiang, Hongfei; Lee, Tai Sing

    2018-04-26

    One general principle of sensory information processing is that the brain must optimize efficiency by reducing the number of neurons that process the same information. The sparseness of the sensory representations in a population of neurons reflects the efficiency of the neural code. Here, we employ large-scale two-photon calcium imaging to examine the responses of a large population of neurons within the superficial layers of area V1 with single-cell resolution, while simultaneously presenting a large set of natural visual stimuli, to provide the first direct measure of the population sparseness in awake primates. The results show that only 0.5% of neurons respond strongly to any given natural image - indicating a ten-fold increase in the inferred sparseness over previous measurements. These population activities are nevertheless necessary and sufficient to discriminate visual stimuli with high accuracy, suggesting that the neural code in the primary visual cortex is both super-sparse and highly efficient. © 2018, Tang et al.

  8. Dark matter and cosmology

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schramm, D.N.

    1992-03-01

    The cosmological dark matter problem is reviewed. The Big Bang Nucleosynthesis constraints on the baryon density are compared with the densities implied by visible matter, dark halos, dynamics of clusters, gravitational lenses, large-scale velocity flows, and the {Omega} = 1 flatness/inflation argument. It is shown that (1) the majority of baryons are dark; and (2) non-baryonic dark matter is probably required on large scales. It is also noted that halo dark matter could be either baryonic or non-baryonic. Descrimination between ``cold`` and ``hot`` non-baryonic candidates is shown to depend on the assumed ``seeds`` that stimulate structure formation. Gaussian density fluctuations,more » such as those induced by quantum fluctuations, favor cold dark matter, whereas topological defects such as strings, textures or domain walls may work equally or better with hot dark matter. A possible connection between cold dark matter, globular cluster ages and the Hubble constant is mentioned. Recent large-scale structure measurements, coupled with microwave anisotropy limits, are shown to raise some questions for the previously favored density fluctuation picture. Accelerator and underground limits on dark matter candidates are also reviewed.« less

  9. Dark matter and cosmology

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schramm, D.N.

    1992-03-01

    The cosmological dark matter problem is reviewed. The Big Bang Nucleosynthesis constraints on the baryon density are compared with the densities implied by visible matter, dark halos, dynamics of clusters, gravitational lenses, large-scale velocity flows, and the {Omega} = 1 flatness/inflation argument. It is shown that (1) the majority of baryons are dark; and (2) non-baryonic dark matter is probably required on large scales. It is also noted that halo dark matter could be either baryonic or non-baryonic. Descrimination between cold'' and hot'' non-baryonic candidates is shown to depend on the assumed seeds'' that stimulate structure formation. Gaussian density fluctuations,more » such as those induced by quantum fluctuations, favor cold dark matter, whereas topological defects such as strings, textures or domain walls may work equally or better with hot dark matter. A possible connection between cold dark matter, globular cluster ages and the Hubble constant is mentioned. Recent large-scale structure measurements, coupled with microwave anisotropy limits, are shown to raise some questions for the previously favored density fluctuation picture. Accelerator and underground limits on dark matter candidates are also reviewed.« less

  10. A KPI-based process monitoring and fault detection framework for large-scale processes.

    PubMed

    Zhang, Kai; Shardt, Yuri A W; Chen, Zhiwen; Yang, Xu; Ding, Steven X; Peng, Kaixiang

    2017-05-01

    Large-scale processes, consisting of multiple interconnected subprocesses, are commonly encountered in industrial systems, whose performance needs to be determined. A common approach to this problem is to use a key performance indicator (KPI)-based approach. However, the different KPI-based approaches are not developed with a coherent and consistent framework. Thus, this paper proposes a framework for KPI-based process monitoring and fault detection (PM-FD) for large-scale industrial processes, which considers the static and dynamic relationships between process and KPI variables. For the static case, a least squares-based approach is developed that provides an explicit link with least-squares regression, which gives better performance than partial least squares. For the dynamic case, using the kernel representation of each subprocess, an instrument variable is used to reduce the dynamic case to the static case. This framework is applied to the TE benchmark process and the hot strip mill rolling process. The results show that the proposed method can detect faults better than previous methods. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.

  11. Dark matter and cosmology

    NASA Astrophysics Data System (ADS)

    Schramm, David N.

    1992-07-01

    The cosmological dark matter problem is reviewed. The Big Bang Nucleosynthesis constraints on the baryon density are compared with the densities implied by visible matter, dark halos, dynamics of clusters, gravitational lenses, large-scale velocity flows, and the Ω = 1 flatness/inflation argument. It is shown that (1) the majority of baryons are dark; and (2) non-baryonic dark matter is probably required on large scales. It is also noted that halo dark matter could be either baryonic or non-baryonic. Descrimination between ``cold'' and ``hot'' non-baryonic candidates is shown to depend on the assumed ``seeds'' that stimulate structure formation. Gaussian density fluctuations, such as those induced by quantum fluctuations, favor cold dark matter, whereas topological defects such as strings, textures or domain walls may work equally or better with hot dark matter. A possible connection between cold dark matter, globular cluster ages and the Hubble constant is mentioned. Recent large-scale structure measurements, coupled with microwave anisotropy limits, are shown to raise some questions for the previously favored density fluctuation picture. Accelerator and underground limits on dark matter candidates are also reviewed.

  12. Dark matter and cosmology

    NASA Astrophysics Data System (ADS)

    Schramm, D. N.

    1992-03-01

    The cosmological dark matter problem is reviewed. The Big Bang nucleosynthesis constraints on the baryon density are compared with the densities implied by visible matter, dark halos, dynamics of clusters, gravitational lenses, large-scale velocity flows, and the omega = 1 flatness/inflation argument. It is shown that (1) the majority of baryons are dark; and (2) non-baryonic dark matter is probably required on large scales. It is also noted that halo dark matter could be either baryonic or non-baryonic. Descrimination between 'cold' and 'hot' non-baryonic candidates is shown to depend on the assumed 'seeds' that stimulate structure formation. Gaussian density fluctuations, such as those induced by quantum fluctuations, favor cold dark matter, whereas topological defects such as strings, textures or domain walls may work equally or better with hot dark matter. A possible connection between cold dark matter, globular cluster ages, and the Hubble constant is mentioned. Recent large-scale structure measurements, coupled with microwave anisotropy limits, are shown to raise some questions for the previously favored density fluctuation picture. Accelerator and underground limits on dark matter candidates are also reviewed.

  13. Large-scale filament formation inhibits the activity of CTP synthetase

    PubMed Central

    Barry, Rachael M; Bitbol, Anne-Florence; Lorestani, Alexander; Charles, Emeric J; Habrian, Chris H; Hansen, Jesse M; Li, Hsin-Jung; Baldwin, Enoch P; Wingreen, Ned S; Kollman, Justin M; Gitai, Zemer

    2014-01-01

    CTP Synthetase (CtpS) is a universally conserved and essential metabolic enzyme. While many enzymes form small oligomers, CtpS forms large-scale filamentous structures of unknown function in prokaryotes and eukaryotes. By simultaneously monitoring CtpS polymerization and enzymatic activity, we show that polymerization inhibits activity, and CtpS's product, CTP, induces assembly. To understand how assembly inhibits activity, we used electron microscopy to define the structure of CtpS polymers. This structure suggests that polymerization sterically hinders a conformational change necessary for CtpS activity. Structure-guided mutagenesis and mathematical modeling further indicate that coupling activity to polymerization promotes cooperative catalytic regulation. This previously uncharacterized regulatory mechanism is important for cellular function since a mutant that disrupts CtpS polymerization disrupts E. coli growth and metabolic regulation without reducing CTP levels. We propose that regulation by large-scale polymerization enables ultrasensitive control of enzymatic activity while storing an enzyme subpopulation in a conformationally restricted form that is readily activatable. DOI: http://dx.doi.org/10.7554/eLife.03638.001 PMID:25030911

  14. The Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup: Posttraumatic Stress Disorder Enters the Age of Large-Scale Genomic Collaboration

    PubMed Central

    Logue, Mark W; Amstadter, Ananda B; Baker, Dewleen G; Duncan, Laramie; Koenen, Karestan C; Liberzon, Israel; Miller, Mark W; Morey, Rajendra A; Nievergelt, Caroline M; Ressler, Kerry J; Smith, Alicia K; Smoller, Jordan W; Stein, Murray B; Sumner, Jennifer A; Uddin, Monica

    2015-01-01

    The development of posttraumatic stress disorder (PTSD) is influenced by genetic factors. Although there have been some replicated candidates, the identification of risk variants for PTSD has lagged behind genetic research of other psychiatric disorders such as schizophrenia, autism, and bipolar disorder. Psychiatric genetics has moved beyond examination of specific candidate genes in favor of the genome-wide association study (GWAS) strategy of very large numbers of samples, which allows for the discovery of previously unsuspected genes and molecular pathways. The successes of genetic studies of schizophrenia and bipolar disorder have been aided by the formation of a large-scale GWAS consortium: the Psychiatric Genomics Consortium (PGC). In contrast, only a handful of GWAS of PTSD have appeared in the literature to date. Here we describe the formation of a group dedicated to large-scale study of PTSD genetics: the PGC-PTSD. The PGC-PTSD faces challenges related to the contingency on trauma exposure and the large degree of ancestral genetic diversity within and across participating studies. Using the PGC analysis pipeline supplemented by analyses tailored to address these challenges, we anticipate that our first large-scale GWAS of PTSD will comprise over 10 000 cases and 30 000 trauma-exposed controls. Following in the footsteps of our PGC forerunners, this collaboration—of a scope that is unprecedented in the field of traumatic stress—will lead the search for replicable genetic associations and new insights into the biological underpinnings of PTSD. PMID:25904361

  15. Large Eddy Simulation of Flame-Turbulence Interactions in a LOX-CH4 Shear Coaxial Injector

    DTIC Science & Technology

    2012-01-01

    heat transfer from dense to light fluids.A previous study on LOX/H2 flames39,40 have pointed the limitations of central scheme to predict such large...pp. 151–169. 39Masquelet, M., Simulations of a Sub-scale Liquid Rocket Engine: Transient Heat Transfer in a Real Gas Environment , Master’s thesis...Eddy Simulation of a cryogenic flame issued from a LOX-CH4 shear coaxial injector. The operating pressure is above the critical pressure for both

  16. Evaluation of Criteria for the Detection of Fires in Underground Conveyor Belt Haulageways

    PubMed Central

    Litton, Charles D.; Perera, Inoka Eranda

    2015-01-01

    Large-scale experiments were conducted in an above-ground gallery to simulate typical fires that develop along conveyor belt transport systems within underground coal mines. In the experiments, electrical strip heaters, imbedded ~5 cm below the top surface of a large mass of coal rubble, were used to ignite the coal, producing an open flame. The flaming coal mass subsequently ignited 1.83-meter-wide conveyor belts located approximately 0.30 m above the coal surface. Gas samples were drawn through an averaging probe located approximately 20 m downstream of the coal for continuous measurement of CO, CO2, and O2 as the fire progressed through the stages of smoldering coal, flaming coal, and flaming conveyor belt. Also located approximately 20 m from the fire origin and approximately 0.5 m below the roof of the gallery were two commercially available smoke detectors, a light obscuration meter, and a sampling probe for measurement of total mass concentration of smoke particles. Located upstream of the fire origin and also along the wall of the gallery at approximately 14 m and 5 m upstream were two video cameras capable of both smoke and flame detection. During the experiments, alarm times of the smoke detectors and video cameras were measured while the smoke obscuration and total smoke mass were continually measured. Twelve large-scale experiments were conducted using three different types of fire-resistant conveyor belts and four air velocities for each belt. The air velocities spanned the range from 1.0 m/s to 6.9 m/s. The results of these experiments are compared to previous large-scale results obtained using a smaller fire gallery and much narrower (1.07-m) conveyor belts to determine if the fire detection criteria previously developed (1) remained valid for the wider conveyor belts. Although some differences between these and the previous experiments did occur, the results, in general, compare very favorably. Differences are duly noted and their impact on fire detection discussed. PMID:26566298

  17. Clumpy filaments of the Chamaeleon I cloud: C18O mapping with the SEST

    NASA Astrophysics Data System (ADS)

    Haikala, L. K.; Harju, J.; Mattila, K.; Toriseva, M.

    2005-02-01

    The Chamaeleon I dark cloud (Cha I) has been mapped in C18O with an angular resolution of 1 arcmin using the SEST telescope. The large scale structures previously observed with lower spatial resolution in the cloud turn into a network of clumpy filaments. The automatic Clumpfind routine developed by \\cite{williams1994} is used to identify individual clumps in a consistent way. Altogether 71 clumps were found and the total mass of these clumps is 230 M⊙. The dense ``cores'' detected with the NANTEN telescope (\\cite{mizuno1999}) and the very cold cores detected in the ISOPHOT serendipity survey (\\cite{toth2000}) form parts of these filaments but decompose into numerous ``clumps''. The filaments are preferentially oriented at right angles to the large-scale magnetic field in the region. We discuss the cloud structure, the physical characteristics of the clumps and the distribution of young stars. The observed clump mass spectrum is compared with the predictions of the turbulent fragmentation model of \\cite{padoan2002}. Agreement is found if fragmentation has been driven by very large-scale hypersonic turbulence, and if by now it has had time to dissipate into modestly supersonic turbulence in the interclump gas. According to numerical simulations, large-scale turbulence should have resulted in filamentary structures as seen in Cha I. The well-oriented magnetic field does not, however, support this picture, but suggests magnetically steered large-scale collapse. The origin of filaments and clumps in Cha I is thus controversial. A possible solution is that the characterization of the driving turbulence fails and that in fact different processes have been effective on small and large scales in this cloud. Based on observations collected at the European Southern Observatory, La Silla, Chile. FITS files are only available in electronic form at http://www.edpsciences.org

  18. Nightside Detection of a Large-Scale Thermospheric Wave Generated by a Solar Eclipse

    NASA Astrophysics Data System (ADS)

    Harding, B. J.; Drob, D. P.; Buriti, R. A.; Makela, J. J.

    2018-04-01

    The generation of a large-scale wave in the upper atmosphere caused by a solar eclipse was first predicted in the 1970s, but the experimental evidence remains sparse and comprises mostly indirect observations. This study presents observations of the wind component of a large-scale thermospheric wave generated by the 21 August 2017 total solar eclipse. In contrast with previous studies, the observations are made on the nightside, after the eclipse ended. A ground-based interferometer located in northeastern Brazil is used to monitor the Doppler shift of the 630.0-nm airglow emission, providing direct measurements of the wind and temperature in the thermosphere, where eclipse effects are expected to be the largest. A disturbance is seen in the zonal and meridional wind which is at or above the 90% significance level based on the measured 30-day variability. These observations are compared with a first principles numerical model calculation from the Thermosphere-Ionosphere-Mesosphere-Electrodynamics General Circulation Model, which predicted the propagation of a large-scale wave well into the nightside. The modeled disturbance matches well the difference between the wind measurements and the 30-day median, though the measured perturbation (˜60 m/s) is larger than the prediction (38 m/s) for the meridional wind. No clear evidence for the wave is seen in the temperature data, however.

  19. Sterile neutrinos with secret interactions — lasting friendship with cosmology

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chu, Xiaoyong; Dasgupta, Basudeb; Kopp, Joachim

    Sterile neutrinos with mass ≃1 eV and order 10% mixing with active neutrinos have been proposed as a solution to anomalies in neutrino oscillation data, but are tightly constrained by cosmological limits. It was recently shown that these constraints are avoided if sterile neutrinos couple to a new MeV-scale gauge boson A{sup ′}. However, even this scenario is restricted by structure formation constraints when A{sup ′}-mediated collisional processes lead to efficient active-to-sterile neutrino conversion after neutrinos have decoupled. In view of this, we reevaluate in this paper the viability of sterile neutrinos with such “secret” interactions. We carefully dissect theirmore » evolution in the early Universe, including the various production channels and the expected modifications to large scale structure formation. We argue that there are two regions in parameter space — one at very small A{sup ′} coupling, one at relatively large A{sup ′} coupling — where all constraints from big bang nucleosynthesis (BBN), cosmic microwave background (CMB), and large scale structure (LSS) data are satisfied. Interestingly, the large A{sup ′} coupling region is precisely the region that was previously shown to have potentially important consequences for the small scale structure of dark matter halos if the A{sup ′} boson couples also to the dark matter in the Universe.« less

  20. Understanding Atmospheric Anomalies Associated With Seasonal Pluvial-Drought Processes Using Southwest China as an Example

    NASA Astrophysics Data System (ADS)

    Liu, Zhenchen; Lu, Guihua; He, Hai; Wu, Zhiyong; He, Jian

    2017-11-01

    Seasonal pluvial-drought transition processes are unique natural phenomena. To explore possible mechanisms, we considered Southwest China (SWC) as the study region and comprehensively investigated the temporal evolution or spatial patterns of large-scale and regional atmospheric variables with the simple method of Standardized Anomalies (SA). Some key procedures and results include the following: (1) Because regional atmospheric variables are more directly responsible for the transition processes, we investigate it in detail. The temporal evolution of net vertical integral water vapor flux (net VIWVF) across SWC, together with vertical SA-based patterns of regional horizontal divergence (D) and vertical motion (ω), coincides well with pluvial-drought transition processes. (2) With respect to large-scale circulation patterns, a well-organized Eurasian (EU) Pattern is one important feature during the pluvial-drought transitions over SWC. (3) Based on these large-scale and regional atmospheric anomalous features, relevant SA-based indices were built, to explore the possibility of simulating drought development using previous pluvial anomalies. As a whole, simulated drought development only with SA-based indices of large-scale circulation patterns does not perform well. Further, it can be improved a lot when SA-based indices of regional D and net VIWVF are introduced. (4) In addition, the potential drought prediction using pluvial anomalies, together with the deep understanding of physical mechanisms responsible for pluvial-drought transitions, need to be further explored.

  1. Mesoderm Lineage 3D Tissue Constructs Are Produced at Large-Scale in a 3D Stem Cell Bioprocess.

    PubMed

    Cha, Jae Min; Mantalaris, Athanasios; Jung, Sunyoung; Ji, Yurim; Bang, Oh Young; Bae, Hojae

    2017-09-01

    Various studies have presented different approaches to direct pluripotent stem cell differentiation such as applying defined sets of exogenous biochemical signals and genetic/epigenetic modifications. Although differentiation to target lineages can be successfully regulated, such conventional methods are often complicated, laborious, and not cost-effective to be employed to the large-scale production of 3D stem cell-based tissue constructs. A 3D-culture platform that could realize the large-scale production of mesoderm lineage tissue constructs from embryonic stem cells (ESCs) is developed. ESCs are cultured using our previously established 3D-bioprocess platform which is amenable to mass-production of 3D ESC-based tissue constructs. Hepatocarcinoma cell line conditioned medium is introduced to the large-scale 3D culture to provide a specific biomolecular microenvironment to mimic in vivo mesoderm formation process. After 5 days of spontaneous differentiation period, the resulting 3D tissue constructs are composed of multipotent mesodermal progenitor cells verified by gene and molecular expression profiles. Subsequently the optimal time points to trigger terminal differentiation towards cardiomyogenesis or osteogenesis from the mesodermal tissue constructs is found. A simple and affordable 3D ESC-bioprocess that can reach the scalable production of mesoderm origin tissues with significantly improved correspondent tissue properties is demonstrated. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Coloration mechanisms and phylogeny of Morpho butterflies.

    PubMed

    Giraldo, M A; Yoshioka, S; Liu, C; Stavenga, D G

    2016-12-15

    Morpho butterflies are universally admired for their iridescent blue coloration, which is due to nanostructured wing scales. We performed a comparative study on the coloration of 16 Morpho species, investigating the morphological, spectral and spatial scattering properties of the differently organized wing scales. In numerous previous studies, the bright blue Morpho coloration has been fully attributed to the multi-layered ridges of the cover scales' upper laminae, but we found that the lower laminae of the cover and ground scales play an important additional role, by acting as optical thin film reflectors. We conclude that Morpho coloration is a subtle combination of overlapping pigmented and/or unpigmented scales, multilayer systems, optical thin films and sometimes undulated scale surfaces. Based on the scales' architecture and their organization, five main groups can be distinguished within the genus Morpho, largely agreeing with the accepted phylogeny. © 2016. Published by The Company of Biologists Ltd.

  3. Seasonal prediction of US summertime ozone using statistical analysis of large scale climate patterns.

    PubMed

    Shen, Lu; Mickley, Loretta J

    2017-03-07

    We develop a statistical model to predict June-July-August (JJA) daily maximum 8-h average (MDA8) ozone concentrations in the eastern United States based on large-scale climate patterns during the previous spring. We find that anomalously high JJA ozone in the East is correlated with these springtime patterns: warm tropical Atlantic and cold northeast Pacific sea surface temperatures (SSTs), as well as positive sea level pressure (SLP) anomalies over Hawaii and negative SLP anomalies over the Atlantic and North America. We then develop a linear regression model to predict JJA MDA8 ozone from 1980 to 2013, using the identified SST and SLP patterns from the previous spring. The model explains ∼45% of the variability in JJA MDA8 ozone concentrations and ∼30% variability in the number of JJA ozone episodes (>70 ppbv) when averaged over the eastern United States. This seasonal predictability results from large-scale ocean-atmosphere interactions. Warm tropical Atlantic SSTs can trigger diabatic heating in the atmosphere and influence the extratropical climate through stationary wave propagation, leading to greater subsidence, less precipitation, and higher temperatures in the East, which increases surface ozone concentrations there. Cooler SSTs in the northeast Pacific are also associated with more summertime heatwaves and high ozone in the East. On average, models participating in the Atmospheric Model Intercomparison Project fail to capture the influence of this ocean-atmosphere interaction on temperatures in the eastern United States, implying that such models would have difficulty simulating the interannual variability of surface ozone in this region.

  4. A phylogeny and revised classification of Squamata, including 4161 species of lizards and snakes

    PubMed Central

    2013-01-01

    Background The extant squamates (>9400 known species of lizards and snakes) are one of the most diverse and conspicuous radiations of terrestrial vertebrates, but no studies have attempted to reconstruct a phylogeny for the group with large-scale taxon sampling. Such an estimate is invaluable for comparative evolutionary studies, and to address their classification. Here, we present the first large-scale phylogenetic estimate for Squamata. Results The estimated phylogeny contains 4161 species, representing all currently recognized families and subfamilies. The analysis is based on up to 12896 base pairs of sequence data per species (average = 2497 bp) from 12 genes, including seven nuclear loci (BDNF, c-mos, NT3, PDC, R35, RAG-1, and RAG-2), and five mitochondrial genes (12S, 16S, cytochrome b, ND2, and ND4). The tree provides important confirmation for recent estimates of higher-level squamate phylogeny based on molecular data (but with more limited taxon sampling), estimates that are very different from previous morphology-based hypotheses. The tree also includes many relationships that differ from previous molecular estimates and many that differ from traditional taxonomy. Conclusions We present a new large-scale phylogeny of squamate reptiles that should be a valuable resource for future comparative studies. We also present a revised classification of squamates at the family and subfamily level to bring the taxonomy more in line with the new phylogenetic hypothesis. This classification includes new, resurrected, and modified subfamilies within gymnophthalmid and scincid lizards, and boid, colubrid, and lamprophiid snakes. PMID:23627680

  5. Seasonal prediction of US summertime ozone using statistical analysis of large scale climate patterns

    PubMed Central

    Mickley, Loretta J.

    2017-01-01

    We develop a statistical model to predict June–July–August (JJA) daily maximum 8-h average (MDA8) ozone concentrations in the eastern United States based on large-scale climate patterns during the previous spring. We find that anomalously high JJA ozone in the East is correlated with these springtime patterns: warm tropical Atlantic and cold northeast Pacific sea surface temperatures (SSTs), as well as positive sea level pressure (SLP) anomalies over Hawaii and negative SLP anomalies over the Atlantic and North America. We then develop a linear regression model to predict JJA MDA8 ozone from 1980 to 2013, using the identified SST and SLP patterns from the previous spring. The model explains ∼45% of the variability in JJA MDA8 ozone concentrations and ∼30% variability in the number of JJA ozone episodes (>70 ppbv) when averaged over the eastern United States. This seasonal predictability results from large-scale ocean–atmosphere interactions. Warm tropical Atlantic SSTs can trigger diabatic heating in the atmosphere and influence the extratropical climate through stationary wave propagation, leading to greater subsidence, less precipitation, and higher temperatures in the East, which increases surface ozone concentrations there. Cooler SSTs in the northeast Pacific are also associated with more summertime heatwaves and high ozone in the East. On average, models participating in the Atmospheric Model Intercomparison Project fail to capture the influence of this ocean–atmosphere interaction on temperatures in the eastern United States, implying that such models would have difficulty simulating the interannual variability of surface ozone in this region. PMID:28223483

  6. Computing Earthquake Probabilities on Global Scales

    NASA Astrophysics Data System (ADS)

    Holliday, James R.; Graves, William R.; Rundle, John B.; Turcotte, Donald L.

    2016-03-01

    Large devastating events in systems such as earthquakes, typhoons, market crashes, electricity grid blackouts, floods, droughts, wars and conflicts, and landslides can be unexpected and devastating. Events in many of these systems display frequency-size statistics that are power laws. Previously, we presented a new method for calculating probabilities for large events in systems such as these. This method counts the number of small events since the last large event and then converts this count into a probability by using a Weibull probability law. We applied this method to the calculation of large earthquake probabilities in California-Nevada, USA. In that study, we considered a fixed geographic region and assumed that all earthquakes within that region, large magnitudes as well as small, were perfectly correlated. In the present article, we extend this model to systems in which the events have a finite correlation length. We modify our previous results by employing the correlation function for near mean field systems having long-range interactions, an example of which is earthquakes and elastic interactions. We then construct an application of the method and show examples of computed earthquake probabilities.

  7. SUSY’s Ladder: Reframing sequestering at Large Volume

    DOE PAGES

    Reece, Matthew; Xue, Wei

    2016-04-07

    Theories with approximate no-scale structure, such as the Large Volume Scenario, have a distinctive hierarchy of multiple mass scales in between TeV gaugino masses and the Planck scale, which we call SUSY's Ladder. This is a particular realization of Split Supersymmetry in which the same small parameter suppresses gaugino masses relative to scalar soft masses, scalar soft masses relative to the gravitino mass, and the UV cutoff or string scale relative to the Planck scale. This scenario has many phenomenologically interesting properties, and can avoid dangers including the gravitino problem, flavor problems, and the moduli-induced LSP problem that plague othermore » supersymmetric theories. We study SUSY's Ladder using a superspace formalism that makes the mysterious cancelations in previous computations manifest. This opens the possibility of a consistent effective field theory understanding of the phenomenology of these scenarios, based on power-counting in the small ratio of string to Planck scales. We also show that four-dimensional theories with approximate no-scale structure enforced by a single volume modulus arise only from two special higher-dimensional theories: five-dimensional supergravity and ten-dimensional type IIB supergravity. As a result, this gives a phenomenological argument in favor of ten dimensional ultraviolet physics which is different from standard arguments based on the consistency of superstring theory.« less

  8. Twisted versus braided magnetic flux ropes in coronal geometry. II. Comparative behaviour

    NASA Astrophysics Data System (ADS)

    Prior, C.; Yeates, A. R.

    2016-06-01

    Aims: Sigmoidal structures in the solar corona are commonly associated with magnetic flux ropes whose magnetic field lines are twisted about a mutual axis. Their dynamical evolution is well studied, with sufficient twisting leading to large-scale rotation (writhing) and vertical expansion, possibly leading to ejection. Here, we investigate the behaviour of flux ropes whose field lines have more complex entangled/braided configurations. Our hypothesis is that this internal structure will inhibit the large-scale morphological changes. Additionally, we investigate the influence of the background field within which the rope is embedded. Methods: A technique for generating tubular magnetic fields with arbitrary axial geometry and internal structure, introduced in part I of this study, provides the initial conditions for resistive-MHD simulations. The tubular fields are embedded in a linear force-free background, and we consider various internal structures for the tubular field, including both twisted and braided topologies. These embedded flux ropes are then evolved using a 3D MHD code. Results: Firstly, in a background where twisted flux ropes evolve through the expected non-linear writhing and vertical expansion, we find that flux ropes with sufficiently braided/entangled interiors show no such large-scale changes. Secondly, embedding a twisted flux rope in a background field with a sigmoidal inversion line leads to eventual reversal of the large-scale rotation. Thirdly, in some cases a braided flux rope splits due to reconnection into two twisted flux ropes of opposing chirality - a phenomenon previously observed in cylindrical configurations. Conclusions: Sufficiently complex entanglement of the magnetic field lines within a flux rope can suppress large-scale morphological changes of its axis, with magnetic energy reduced instead through reconnection and expansion. The structure of the background magnetic field can significantly affect the changing morphology of a flux rope.

  9. The electrostatic persistence length of polymers beyond the OSF limit.

    PubMed

    Everaers, R; Milchev, A; Yamakov, V

    2002-05-01

    We use large-scale Monte Carlo simulations to test scaling theories for the electrostatic persistence length l(e) of isolated, uniformly charged polymers with Debye-Hückel intrachain interactions in the limit where the screening length kappa(-1) exceeds the intrinsic persistence length of the chains. Our simulations cover a significantly larger part of the parameter space than previous studies. We observe no significant deviations from the prediction l(e) proportional to kappa(-2) by Khokhlov and Khachaturian which is based on applying the Odijk-Skolnick-Fixman theories of electrostatic bending rigidity and electrostatically excluded volume to the stretched de Gennes-Pincus-Velasco-Brochard polyelectrolyte blob chain. A linear or sublinear dependence of the persistence length on the screening length can be ruled out. We show that previous results pointing into this direction are due to a combination of excluded-volume and finite chain length effects. The paper emphasizes the role of scaling arguments in the development of useful representations for experimental and simulation data.

  10. A new subgrid-scale representation of hydrometeor fields using a multivariate PDF

    DOE PAGES

    Griffin, Brian M.; Larson, Vincent E.

    2016-06-03

    The subgrid-scale representation of hydrometeor fields is important for calculating microphysical process rates. In order to represent subgrid-scale variability, the Cloud Layers Unified By Binormals (CLUBB) parameterization uses a multivariate probability density function (PDF). In addition to vertical velocity, temperature, and moisture fields, the PDF includes hydrometeor fields. Previously, hydrometeor fields were assumed to follow a multivariate single lognormal distribution. Now, in order to better represent the distribution of hydrometeors, two new multivariate PDFs are formulated and introduced.The new PDFs represent hydrometeors using either a delta-lognormal or a delta-double-lognormal shape. The two new PDF distributions, plus the previous single lognormalmore » shape, are compared to histograms of data taken from large-eddy simulations (LESs) of a precipitating cumulus case, a drizzling stratocumulus case, and a deep convective case. In conclusion, the warm microphysical process rates produced by the different hydrometeor PDFs are compared to the same process rates produced by the LES.« less

  11. Laminar and Turbulent Dynamos in Chiral Magnetohydrodynamics. II. Simulations

    NASA Astrophysics Data System (ADS)

    Schober, Jennifer; Rogachevskii, Igor; Brandenburg, Axel; Boyarsky, Alexey; Fröhlich, Jürg; Ruchayskiy, Oleg; Kleeorin, Nathan

    2018-05-01

    Using direct numerical simulations (DNS), we study laminar and turbulent dynamos in chiral magnetohydrodynamics with an extended set of equations that accounts for an additional contribution to the electric current due to the chiral magnetic effect (CME). This quantum phenomenon originates from an asymmetry between left- and right-handed relativistic fermions in the presence of a magnetic field and gives rise to a chiral dynamo. We show that the magnetic field evolution proceeds in three stages: (1) a small-scale chiral dynamo instability, (2) production of chiral magnetically driven turbulence and excitation of a large-scale dynamo instability due to a new chiral effect (α μ effect), and (3) saturation of magnetic helicity and magnetic field growth controlled by a conservation law for the total chirality. The α μ effect becomes dominant at large fluid and magnetic Reynolds numbers and is not related to kinetic helicity. The growth rate of the large-scale magnetic field and its characteristic scale measured in the numerical simulations agree well with theoretical predictions based on mean-field theory. The previously discussed two-stage chiral magnetic scenario did not include stage (2), during which the characteristic scale of magnetic field variations can increase by many orders of magnitude. Based on the findings from numerical simulations, the relevance of the CME and the chiral effects revealed in the relativistic plasma of the early universe and of proto-neutron stars are discussed.

  12. Camphor-Enabled Transfer and Mechanical Testing of Centimeter-Scale Ultrathin Films.

    PubMed

    Wang, Bin; Luo, Da; Li, Zhancheng; Kwon, Youngwoo; Wang, Meihui; Goo, Min; Jin, Sunghwan; Huang, Ming; Shen, Yongtao; Shi, Haofei; Ding, Feng; Ruoff, Rodney S

    2018-05-21

    Camphor is used to transfer centimeter-scale ultrathin films onto custom-designed substrates for mechanical (tensile) testing. Compared to traditional transfer methods using dissolving/peeling to remove the support-layers, camphor is sublimed away in air at low temperature, thereby avoiding additional stress on the as-transferred films. Large-area ultrathin films can be transferred onto hollow substrates without damage by this method. Tensile measurements are made on centimeter-scale 300 nm-thick graphene oxide film specimens, much thinner than the ≈2 μm minimum thickness of macroscale graphene-oxide films previously reported. Tensile tests were also done on two different types of large-area samples of adlayer free CVD-grown single-layer graphene supported by a ≈100 nm thick polycarbonate film; graphene stiffens this sample significantly, thus the intrinsic mechanical response of the graphene can be extracted. This is the first tensile measurement of centimeter-scale monolayer graphene films. The Young's modulus of polycrystalline graphene ranges from 637 to 793 GPa, while for near single-crystal graphene, it ranges from 728 to 908 GPa (folds parallel to the tensile loading direction) and from 683 to 775 GPa (folds orthogonal to the tensile loading direction), demonstrating the mechanical performance of large-area graphene in a size scale relevant to many applications. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. Application of remote sensor data to geologic analysis of the Bonanza Test Site Colorado

    NASA Technical Reports Server (NTRS)

    Lee, K. (Compiler)

    1973-01-01

    A geologic map of the Bonanza Test Site is nearing completion. Using published large scale geologic maps from various sources, the geology of the area is being compiled on a base scaled at 1:250,000. Sources of previously published geologic mapping include: (1) USGS Bulletins; (2) professional papers and geologic quadrangle maps; (3) Bureau of Mines reports; (4) Colorado School of Mines quarterlies; and (5) Rocky Mountain Association of Geologist Guidebooks. This compilation will be used to evaluate ERTS, Skylab, and remote sensing underflight data.

  14. Characterizing and understanding the climatic determinism of high- to low-frequency variations in precipitation in northwestern France using a coupled wavelet multiresolution/statistical downscaling approach

    NASA Astrophysics Data System (ADS)

    Massei, Nicolas; Dieppois, Bastien; Hannah, David; Lavers, David; Fossa, Manuel; Laignel, Benoit; Debret, Maxime

    2017-04-01

    Geophysical signals oscillate over several time-scales that explain different amount of their overall variability and may be related to different physical processes. Characterizing and understanding such variabilities in hydrological variations and investigating their determinism is one important issue in a context of climate change, as these variabilities can be occasionally superimposed to long-term trend possibly due to climate change. It is also important to refine our understanding of time-scale dependent linkages between large-scale climatic variations and hydrological responses on the regional or local-scale. Here we investigate such links by conducting a wavelet multiresolution statistical dowscaling approach of precipitation in northwestern France (Seine river catchment) over 1950-2016 using sea level pressure (SLP) and sea surface temperature (SST) as indicators of atmospheric and oceanic circulations, respectively. Previous results demonstrated that including multiresolution decomposition in a statistical downscaling model (within a so-called multiresolution ESD model) using SLP as large-scale predictor greatly improved simulation of low-frequency, i.e. interannual to interdecadal, fluctuations observed in precipitation. Building on these results, continuous wavelet transform of simulated precipiation using multiresolution ESD confirmed the good performance of the model to better explain variability at all time-scales. A sensitivity analysis of the model to the choice of the scale and wavelet function used was also tested. It appeared that whatever the wavelet used, the model performed similarly. The spatial patterns of SLP found as the best predictors for all time-scales, which resulted from the wavelet decomposition, revealed different structures according to time-scale, showing possible different determinisms. More particularly, some low-frequency components ( 3.2-yr and 19.3-yr) showed a much wide-spread spatial extentsion across the Atlantic. Moreover, in accordance with other previous studies, the wavelet components detected in SLP and precipitation on interannual to interdecadal time-scales could be interpreted in terms of influence of the Gulf-Stream oceanic front on atmospheric circulation. Current works are now conducted including SST over the Atlantic in order to get further insights into this mechanism.

  15. The problem of ecological scaling in spatially complex, nonequilibrium ecological systems [chapter 3

    Treesearch

    Samuel A. Cushman; Jeremy Littell; Kevin McGarigal

    2010-01-01

    In the previous chapter we reviewed the challenges posed by spatial complexity and temporal disequilibrium to efforts to understand and predict the structure and dynamics of ecological systems. The central theme was that spatial variability in the environment and population processes fundamentally alters the interactions between species and their environments, largely...

  16. Validity of the Autism Spectrum Disorder Observation for Children (ASD-OC)

    ERIC Educational Resources Information Center

    Neal, Daniene; Matson, Johnny L.; Hattier, Megan A.

    2014-01-01

    The Autism Spectrum Disorder Observation for Children (ASD-OC) is a 45-item observation scale used to assess autistic symptomatology. The reliability of this measure has been established in previous research; therefore, the purpose of this study is to evaluate its validity among a sample of children (1-15 years). The large correlation between the…

  17. DIF Analysis with Multilevel Data: A Simulation Study Using the Latent Variable Approach

    ERIC Educational Resources Information Center

    Jin, Ying; Eason, Hershel

    2016-01-01

    The effects of mean ability difference (MAD) and short tests on the performance of various DIF methods have been studied extensively in previous simulation studies. Their effects, however, have not been studied under multilevel data structure. MAD was frequently observed in large-scale cross-country comparison studies where the primary sampling…

  18. Data Use Agreement | Office of Cancer Clinical Proteomics Research

    Cancer.gov

    CPTAC requests that data users abide by the same principles that were previously established in the Fort Lauderdale and Amsterdam meetings. The recommendations from the Fort Lauderdale meeting (2003) on best practices and principles for sharing large-scale genomic data address the roles and responsibilities of data producers, data users and funders of community resource projects.

  19. Discussing the Flynn Effect: From Causes and Interpretation to Implications

    ERIC Educational Resources Information Center

    Kanaya, Tomoe

    2016-01-01

    Clark, Lawlor-Savage, and Goghari (this issue) point out that evidence of IQ rises had been documented decades before it was named the Flynn effect. These previous studies, however, were conducted sporadically and in isolated samples. Flynn (1984, 1987) examined them in a large-scale manner and was able to show their systematic and global nature.…

  20. 2016 Offshore Wind Energy Resource Assessment for the United States

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Musial, Walt; Heimiller, Donna; Beiter, Philipp

    2016-09-01

    This report, the 2016 Offshore Wind Energy Resource Assessment for the United States, was developed by the National Renewable Energy Laboratory, and updates a previous national resource assessment study, and refines and reaffirms that the available wind resource is sufficient for offshore wind to be a large-scale contributor to the nation's electric energy supply.

  1. Leadership Identity in Ethnically Diverse Schools in South Africa and England

    ERIC Educational Resources Information Center

    Lumby, Jacky; Heystek, Jan

    2012-01-01

    This article adopts an international perspective to examine the perceptions and practice of leaders in a South African and an English primary school and the leadership implications. Both schools have experienced a relatively swift and large scale diversification of learners away from the previous white majority. In each case the educators have not…

  2. Teachers as Agents of Change in Curricular Reform: The Position of Dance Revisited

    ERIC Educational Resources Information Center

    MacLean, Justine

    2018-01-01

    This paper reports findings from a recent large-scale survey of Physical Education (PE) teachers' perceptions of teaching dance and compares them to results of a study completed 10 years previously [MacLean, J. (2007). A longitudinal study to ascertain the factors that impact on the confidence of undergraduate physical education student teachers…

  3. Increasing Minority Children's Participation in Gifted Classes Using the NNAT: A Response to Lohman

    ERIC Educational Resources Information Center

    Naglieri, Jack A.; Ford, Donna Y.

    2005-01-01

    In a previous article, we (Naglieri & Ford, 2003) provided evidence from a large-scale study that similar proportions of White, Black, and Hispanic children would be identified as gifted using the Naglieri Nonverbal Ability Test (NNAT; Naglieri, 1997). Lohman (2005) has taken issue with our conclusions and our methods. We provide several…

  4. Variables Affecting Secondary School Students' Willingness to Eat Genetically Modified Food Crops

    ERIC Educational Resources Information Center

    Maes, Jasmien; Bourgonjon, Jeroen; Gheysen, Godelieve; Valcke, Martin

    2018-01-01

    A large-scale cross-sectional study (N = 4002) was set up to determine Flemish secondary school students' willingness to eat genetically modified food (WTE) and to link students' WTE to previously identified key variables from research on the acceptance of genetic modification (GM). These variables include subjective and objective knowledge about…

  5. Monitoring Ecosystems and Biodiversity at a Continental Scale--A Proposal for South America

    Treesearch

    Xavier Silva

    2006-01-01

    A monitoring system plan is being developed in South America to assess critically endangered ecoregions. The system will be based on a previous ecosystem and biodiversity inventory developed through a large gap analysis program in five South American ecoregions. The monitoring system will include three main elements: (1) Landscape Ecology: vegetation cover,...

  6. Deeper Look at Student Learning of Quantum Mechanics: The Case of Tunneling

    ERIC Educational Resources Information Center

    McKagan, S. B.; Perkins, K. K.; Wieman, C. E.

    2008-01-01

    We report on a large-scale study of student learning of quantum tunneling in four traditional and four transformed modern physics courses. In the transformed courses, which were designed to address student difficulties found in previous research, students still struggle with many of the same issues found in other courses. However, the reasons for…

  7. Restoration of degraded tropical forest landscapes. Science 310(5754): 1628-1632.

    Treesearch

    David Lamb; Peter Erskine; John A. Parrotta

    2005-01-01

    The current scale of deforestation in tropical regions and the large areas of degraded lands now present underscore the urgent need for interventions to restore biodiversity, ecological functioning, and the supply of goods and ecological services previously used by poor rural communities. Traditional timber plantations have supplied some goods but have made only minor...

  8. Modeling relationships between landscape-level attributes and snorkel counts of chinook salmon and steelhead parr in Idaho

    Treesearch

    William L. Thompson; Danny C. Lee

    2000-01-01

    Knowledge of environmental factors impacting anadromous salmonids in their freshwater habitats, particularly at large spatial scales, may be important for restoring them to previously recorded levels in the northwestern United States. Consequently, we used existing data sets and an information-theoretic approach to model landscape-level attributes and snorkel count...

  9. LSI logic for phase-control rectifiers

    NASA Technical Reports Server (NTRS)

    Dolland, C.

    1980-01-01

    Signals for controlling phase-controlled rectifier circuit are generated by combinatorial logic than can be implemented in large-scale integration (LSI). LSI circuit saves space, weight, and assembly time compared to previous controls that employ one-shot multivibrators, latches, and capacitors. LSI logic functions by sensing three phases of ac power source and by comparing actual currents with intended currents.

  10. Structural Similitude and Scaling Laws

    NASA Technical Reports Server (NTRS)

    Simitses, George J.

    1998-01-01

    Aircraft and spacecraft comprise the class of aerospace structures that require efficiency and wisdom in design, sophistication and accuracy in analysis and numerous and careful experimental evaluations of components and prototype, in order to achieve the necessary system reliability, performance and safety. Preliminary and/or concept design entails the assemblage of system mission requirements, system expected performance and identification of components and their connections as well as of manufacturing and system assembly techniques. This is accomplished through experience based on previous similar designs, and through the possible use of models to simulate the entire system characteristics. Detail design is heavily dependent on information and concepts derived from the previous steps. This information identifies critical design areas which need sophisticated analyses, and design and redesign procedures to achieve the expected component performance. This step may require several independent analysis models, which, in many instances, require component testing. The last step in the design process, before going to production, is the verification of the design. This step necessitates the production of large components and prototypes in order to test component and system analytical predictions and verify strength and performance requirements under the worst loading conditions that the system is expected to encounter in service. Clearly then, full-scale testing is in many cases necessary and always very expensive. In the aircraft industry, in addition to full-scale tests, certification and safety necessitate large component static and dynamic testing. Such tests are extremely difficult, time consuming and definitely absolutely necessary. Clearly, one should not expect that prototype testing will be totally eliminated in the aircraft industry. It is hoped, though, that we can reduce full-scale testing to a minimum. Full-scale large component testing is necessary in other industries as well, Ship building, automobile and railway car construction all rely heavily on testing. Regardless of the application, a scaled-down (by a large factor) model (scale model) which closely represents the structural behavior of the full-scale system (prototype) can prove to be an extremely beneficial tool. This possible development must be based on the existence of certain structural parameters that control the behavior of a structural system when acted upon by static and/or dynamic loads. If such structural parameters exist, a scaled-down replica can be built, which will duplicate the response of the full-scale system. The two systems are then said to be structurally similar. The term, then, that best describes this similarity is structural similitude. Similarity of systems requires that the relevant system parameters be identical and these systems be governed by a unique set of characteristic equations. Thus, if a relation or equation of variables is written for a system, it is valid for all systems which are similar to it. Each variable in a model is proportional to the corresponding variable of the prototype. This ratio, which plays an essential role in predicting the relationship between the model and its prototype, is called the scale factor.

  11. Local protoplanetary disk ionisation by T Tauri star energetic particles

    NASA Astrophysics Data System (ADS)

    Fraschetti, F.; Drake, J.; Cohen, O.; Garraffo, C.

    2017-10-01

    The evolution of protoplanetary disks is believed to be driven largely by viscosity. The ionization of the disk that gives rise to viscosity is caused by X-rays from the central star or by energetic particles released by shock waves travelling into the circumstellar medium. We have performed test-particle numerical simulations of GeV-scale protons traversing a realistic magnetised wind of a young solar mass star with a superposed small-scale turbulence. The large-scale field is generated via an MHD model of a T Tauri wind, whereas the isotropic (Kolmogorov power spectrum) turbulent component is synthesised along the particles' trajectories. We have combined Chandra observations of T Tauri flares with solar flare scaling for describing the energetic particle spectrum. In contrast with previous models, we find that the disk ionization is dominated by X-rays except within narrow regions where the energetic particles are channelled onto the disk by the strongly tangled and turbulent field lines; the radial thickness of such regions broadens with the distance from the central star (5 stellar radii or more). In those regions, the disk ionization due to energetic particles can locally dominate the stellar X-rays, arguably, out to large distances (10, 100 AU) from the star.

  12. Predictors of breeding site occupancy by amphibians in montane landscapes

    USGS Publications Warehouse

    Groff, Luke A.; Loftin, Cynthia S.; Calhoun, Aram J.K.

    2017-01-01

    Ecological relationships and processes vary across species’ geographic distributions, life stages and spatial, and temporal scales. Montane landscapes are characterized by low wetland densities, rugged topographies, and cold climates. Consequently, aquatic-dependent and low-vagility ectothermic species (e.g., pool-breeding amphibians) may exhibit unique ecological associations in montane landscapes. We evaluated the relative importance of breeding- and landscape-scale features associated with spotted salamander (Ambystoma maculatum) and wood frog (Lithobates sylvaticus) wetland occupancy in Maine's Upper Montane-Alpine Zone ecoregion, and we determined whether models performed better when the inclusive landscape-scale covariates were estimated with topography-weighted or circular buffers. We surveyed 135 potential breeding sites during May 2013–June 2014 and evaluated environmental relationships with multi-season implicit dynamics occupancy models. Breeding site occupancy by both species was influenced solely by breeding-scale habitat features. Spotted salamander occupancy probabilities increased with previous or current beaver (Castor canadensis) presence, and models generally were better supported when the inclusive landscape-scale covariates were estimated with topography-weighted rather than circular buffers. Wood frog occupancy probabilities increased with site area and percent shallows, but neither buffer type was better supported than the other. Model rank order and support varied between buffer types, but model inferences did not. Our results suggest pool-breeding amphibian conservation in montane Maine include measures to maintain beaver populations and large wetlands with proportionally large areas of shallows ≤1-m deep. Inconsistencies between our study and previous studies substantiate the value of region-specific research for augmenting species’ conservation management plans and suggest the application of out-of-region inferences may promote ineffective conservation. 

  13. Evaluating 20th Century precipitation characteristics between multi-scale atmospheric models with different land-atmosphere coupling

    NASA Astrophysics Data System (ADS)

    Phillips, M.; Denning, A. S.; Randall, D. A.; Branson, M.

    2016-12-01

    Multi-scale models of the atmosphere provide an opportunity to investigate processes that are unresolved by traditional Global Climate Models while at the same time remaining viable in terms of computational resources for climate-length time scales. The MMF represents a shift away from large horizontal grid spacing in traditional GCMs that leads to overabundant light precipitation and lack of heavy events, toward a model where precipitation intensity is allowed to vary over a much wider range of values. Resolving atmospheric motions on the scale of 4 km makes it possible to recover features of precipitation, such as intense downpours, that were previously only obtained by computationally expensive regional simulations. These heavy precipitation events may have little impact on large-scale moisture and energy budgets, but are outstanding in terms of interaction with the land surface and potential impact on human life. Three versions of the Community Earth System Model were used in this study; the standard CESM, the multi-scale `Super-Parameterized' CESM where large-scale parameterizations have been replaced with a 2D cloud-permitting model, and a multi-instance land version of the SP-CESM where each column of the 2D CRM is allowed to interact with an individual land unit. These simulations were carried out using prescribed Sea Surface Temperatures for the period from 1979-2006 with daily precipitation saved for all 28 years. Comparisons of the statistical properties of precipitation between model architectures and against observations from rain gauges were made, with specific focus on detection and evaluation of extreme precipitation events.

  14. Wafer level reliability for high-performance VLSI design

    NASA Technical Reports Server (NTRS)

    Root, Bryan J.; Seefeldt, James D.

    1987-01-01

    As very large scale integration architecture requires higher package density, reliability of these devices has approached a critical level. Previous processing techniques allowed a large window for varying reliability. However, as scaling and higher current densities push reliability to its limit, tighter control and instant feedback becomes critical. Several test structures developed to monitor reliability at the wafer level are described. For example, a test structure was developed to monitor metal integrity in seconds as opposed to weeks or months for conventional testing. Another structure monitors mobile ion contamination at critical steps in the process. Thus the reliability jeopardy can be assessed during fabrication preventing defective devices from ever being placed in the field. Most importantly, the reliability can be assessed on each wafer as opposed to an occasional sample.

  15. Comparing multi-module connections in membrane chromatography scale-up.

    PubMed

    Yu, Zhou; Karkaria, Tishtar; Espina, Marianela; Hunjun, Manjeet; Surendran, Abera; Luu, Tina; Telychko, Julia; Yang, Yan-Ping

    2015-07-20

    Membrane chromatography is increasingly used for protein purification in the biopharmaceutical industry. Membrane adsorbers are often pre-assembled by manufacturers as ready-to-use modules. In large-scale protein manufacturing settings, the use of multiple membrane modules for a single batch is often required due to the large quantity of feed material. The question as to how multiple modules can be connected to achieve optimum separation and productivity has been previously approached using model proteins and mass transport theories. In this study, we compare the performance of multiple membrane modules in series and in parallel in the production of a protein antigen. Series connection was shown to provide superior separation compared to parallel connection in the context of competitive adsorption. Copyright © 2015 Elsevier B.V. All rights reserved.

  16. CROSS-DISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY: Novel Route to Fabrication of Metal-Sandwiched Nanoscale Tapered Structures

    NASA Astrophysics Data System (ADS)

    Zhang, Yang; Yu, Da-Peng

    2009-08-01

    Tapered dielectric structures in metal have exhibited extraordinary performance in both surface plasmon polariton (SPP) waveguiding and SPP focusing. This is crucial to plasmonic research and industrial plasmonic device integration. We present a method that facilitates easy fabrication of smooth-surfaced sub-micron tapered structures in large scale simply with electron beam lithography (EBL). When a PMMA layer is spin-coated on previously-EBL-defined PMMA structures, steep edges can be transformed into a declining slope to form tapered PMMA structures, scaled from 10 nm to 1000 nm. Despite the simplicity of our method, patterns with PMMA surface smoothness can be well-positioned and replicated in large numbers, which therefore gives scientists easy access to research on the properties of tapered structures.

  17. Evaluating Hierarchical Structure in Music Annotations

    PubMed Central

    McFee, Brian; Nieto, Oriol; Farbood, Morwaread M.; Bello, Juan Pablo

    2017-01-01

    Music exhibits structure at multiple scales, ranging from motifs to large-scale functional components. When inferring the structure of a piece, different listeners may attend to different temporal scales, which can result in disagreements when they describe the same piece. In the field of music informatics research (MIR), it is common to use corpora annotated with structural boundaries at different levels. By quantifying disagreements between multiple annotators, previous research has yielded several insights relevant to the study of music cognition. First, annotators tend to agree when structural boundaries are ambiguous. Second, this ambiguity seems to depend on musical features, time scale, and genre. Furthermore, it is possible to tune current annotation evaluation metrics to better align with these perceptual differences. However, previous work has not directly analyzed the effects of hierarchical structure because the existing methods for comparing structural annotations are designed for “flat” descriptions, and do not readily generalize to hierarchical annotations. In this paper, we extend and generalize previous work on the evaluation of hierarchical descriptions of musical structure. We derive an evaluation metric which can compare hierarchical annotations holistically across multiple levels. sing this metric, we investigate inter-annotator agreement on the multilevel annotations of two different music corpora, investigate the influence of acoustic properties on hierarchical annotations, and evaluate existing hierarchical segmentation algorithms against the distribution of inter-annotator agreement. PMID:28824514

  18. When is best-worst best? A comparison of best-worst scaling, numeric estimation, and rating scales for collection of semantic norms.

    PubMed

    Hollis, Geoff; Westbury, Chris

    2018-02-01

    Large-scale semantic norms have become both prevalent and influential in recent psycholinguistic research. However, little attention has been directed towards understanding the methodological best practices of such norm collection efforts. We compared the quality of semantic norms obtained through rating scales, numeric estimation, and a less commonly used judgment format called best-worst scaling. We found that best-worst scaling usually produces norms with higher predictive validities than other response formats, and does so requiring less data to be collected overall. We also found evidence that the various response formats may be producing qualitatively, rather than just quantitatively, different data. This raises the issue of potential response format bias, which has not been addressed by previous efforts to collect semantic norms, likely because of previous reliance on a single type of response format for a single type of semantic judgment. We have made available software for creating best-worst stimuli and scoring best-worst data. We also made available new norms for age of acquisition, valence, arousal, and concreteness collected using best-worst scaling. These norms include entries for 1,040 words, of which 1,034 are also contained in the ANEW norms (Bradley & Lang, Affective norms for English words (ANEW): Instruction manual and affective ratings (pp. 1-45). Technical report C-1, the center for research in psychophysiology, University of Florida, 1999).

  19. Evolution of the magnetorotational instability on initially tangled magnetic fields

    NASA Astrophysics Data System (ADS)

    Bhat, Pallavi; Ebrahimi, Fatima; Blackman, Eric G.; Subramanian, Kandaswamy

    2017-12-01

    The initial magnetic field of previous magnetorotational instability (MRI) simulations has always included a significant system-scale component, even if stochastic. However, it is of conceptual and practical interest to assess whether the MRI can grow when the initial field is turbulent. The ubiquitous presence of turbulent or random flows in astrophysical plasmas generically leads to a small-scale dynamo (SSD), which would provide initial seed turbulent velocity and magnetic fields in the plasma that becomes an accretion disc. Can the MRI grow from these more realistic initial conditions? To address this, we supply a standard shearing box with isotropically forced SSD generated magnetic and velocity fields as initial conditions and remove the forcing. We find that if the initially supplied fields are too weak or too incoherent, they decay from the initial turbulent cascade faster than they can grow via the MRI. When the initially supplied fields are sufficient to allow MRI growth and sustenance, the saturated stresses, large-scale fields and power spectra match those of the standard zero net flux MRI simulation with an initial large-scale vertical field.

  20. Flank vents and graben as indicators of Late Amazonian volcanotectonic activity on Olympus Mons

    NASA Astrophysics Data System (ADS)

    Peters, S. I.; Christensen, P. R.

    2017-03-01

    Previous studies have focused on large-scale features on Olympus Mons, such as its flank terraces, the summit caldera complex, and the basal escarpment and aureole deposits. Here we identify and characterize previously unrecognized and unmapped small scale features to help further understand the volcanotectonic evolution of this enormous volcano. Using Context Camera, High Resolution Imaging Science Experiment, Thermal Emission Imaging System, High Resolution Stereo Camera Digital Terrain Model, and Mars Orbiter Laser Altimeter data, we identified and characterized the morphology and distribution of 60 flank vents and 84 grabens on Olympus Mons. We find that effusive eruptions have dominated volcanic activity on Olympus Mons in the Late Amazonian. Explosive eruptions were rare, implying volatile-poor magmas and/or a lack of magma-water interactions during the Late Amazonian. The distribution of flank vents suggests dike propagation of hundreds of kilometers and shallow magma storage. Small grabens, not previously observed in lower-resolution data, occur primarily on the lower flanks of Olympus Mons and indicate late-stage extensional tectonism. Based on superposition relationships, we have concluded two stages of development for Olympus Mons during the Late Amazonian: (1) primarily effusive resurfacing and formation of flank vents followed by (2) waning effusive volcanism and graben formation and/or reactivation. This developmental sequence resembles that proposed for Ascraeus Mons and other large Martian shields, suggesting a similar geologic evolution for these volcanoes.

  1. Recurrent patterning in the daily foraging routes of hamadryas baboons (Papio hamadryas): spatial memory in large-scale versus small-scale space.

    PubMed

    Schreier, Amy L; Grove, Matt

    2014-05-01

    The benefits of spatial memory for foraging animals can be assessed on two distinct spatial scales: small-scale space (travel within patches) and large-scale space (travel between patches). While the patches themselves may be distributed at low density, within patches resources are likely densely distributed. We propose, therefore, that spatial memory for recalling the particular locations of previously visited feeding sites will be more advantageous during between-patch movement, where it may reduce the distances traveled by animals that possess this ability compared to those that must rely on random search. We address this hypothesis by employing descriptive statistics and spectral analyses to characterize the daily foraging routes of a band of wild hamadryas baboons in Filoha, Ethiopia. The baboons slept on two main cliffs--the Filoha cliff and the Wasaro cliff--and daily travel began and ended on a cliff; thus four daily travel routes exist: Filoha-Filoha, Filoha-Wasaro, Wasaro-Wasaro, Wasaro-Filoha. We use newly developed partial sum methods and distribution-fitting analyses to distinguish periods of area-restricted search from more extensive movements. The results indicate a single peak in travel activity in the Filoha-Filoha and Wasaro-Filoha routes, three peaks of travel activity in the Filoha-Wasaro routes, and two peaks in the Wasaro-Wasaro routes; and are consistent with on-the-ground observations of foraging and ranging behavior of the baboons. In each of the four daily travel routes the "tipping points" identified by the partial sum analyses indicate transitions between travel in small- versus large-scale space. The correspondence between the quantitative analyses and the field observations suggest great utility for using these types of analyses to examine primate travel patterns and especially in distinguishing between movement in small versus large-scale space. Only the distribution-fitting analyses are inconsistent with the field observations, which may be due to the scale at which these analyses were conducted. © 2013 Wiley Periodicals, Inc.

  2. Images of Bottomside Irregularities Observed at Topside Altitudes

    NASA Technical Reports Server (NTRS)

    Burke, William J.; Gentile, Louise C.; Shomo, Shannon R.; Roddy, Patrick A.; Pfaff, Robert F.

    2012-01-01

    We analyzed plasma and field measurements acquired by the Communication/ Navigation Outage Forecasting System (C/NOFS) satellite during an eight-hour period on 13-14 January 2010 when strong to moderate 250 MHz scintillation activity was observed at nearby Scintillation Network Decision Aid (SCINDA) ground stations. C/NOFS consistently detected relatively small-scale density and electric field irregularities embedded within large-scale (approx 100 km) structures at topside altitudes. Significant spectral power measured at the Fresnel (approx 1 km) scale size suggests that C/NOFS was magnetically conjugate to bottomside irregularities similar to those directly responsible for the observed scintillations. Simultaneous ion drift and plasma density measurements indicate three distinct types of large-scale irregularities: (1) upward moving depletions, (2) downward moving depletions, and (3) upward moving density enhancements. The first type has the characteristics of equatorial plasma bubbles; the second and third do not. The data suggest that both downward moving depletions and upward moving density enhancements and the embedded small-scale irregularities may be regarded as Alfvenic images of bottomside irregularities. This interpretation is consistent with predictions of previously reported theoretical modeling and with satellite observations of upward-directed Poynting flux in the low-latitude ionosphere.

  3. Multifarious anchovy and sardine regimes in the Humboldt Current System during the last 150 years.

    PubMed

    Salvatteci, Renato; Field, David; Gutiérrez, Dimitri; Baumgartner, Tim; Ferreira, Vicente; Ortlieb, Luc; Sifeddine, Abdel; Grados, Daniel; Bertrand, Arnaud

    2018-03-01

    The Humboldt Current System (HCS) has the highest production of forage fish in the world, although it is highly variable and the future of the primary component, anchovy, is uncertain in the context of global warming. Paradigms based on late 20th century observations suggest that large-scale forcing controls decadal-scale fluctuations of anchovy and sardine across different boundary currents of the Pacific. We develop records of anchovy and sardine fluctuations since 1860 AD using fish scales from multiple sites containing laminated sediments and compare them with Pacific basin-scale and regional indices of ocean climate variability. Our records reveal two main anchovy and sardine phases with a timescale that is not consistent with previously proposed periodicities. Rather, the regime shifts in the HCS are related to 3D habitat changes driven by changes in upwelling intensity from both regional and large-scale forcing. Moreover, we show that a long-term increase in coastal upwelling translates via a bottom-up mechanism to top predators suggesting that the warming climate, at least up to the start of the 21st century, was favorable for fishery productivity in the HCS. © 2017 John Wiley & Sons Ltd.

  4. A multiscale strength model for tantalum over an extended range of strain rates

    NASA Astrophysics Data System (ADS)

    Barton, N. R.; Rhee, M.

    2013-09-01

    A strength model for tantalum is developed and exercised across a range of conditions relevant to various types of experimental observations. The model is based on previous multiscale modeling work combined with experimental observations. As such, the model's parameterization includes a hybrid of quantities that arise directly from predictive sub-scale physics models and quantities that are adjusted to align the model with experimental observations. Given current computing and experimental limitations, the response regions for sub-scale physics simulations and detailed experimental observations have been largely disjoint. In formulating the new model and presenting results here, attention is paid to integrated experimental observations that probe strength response at the elevated strain rates where a previous version of the model has generally been successful in predicting experimental data [Barton et al., J. Appl. Phys. 109(7), 073501 (2011)].

  5. Complex submarine landsliding processes caused by subduction of large seamounts along the Middle America Trench

    NASA Astrophysics Data System (ADS)

    Harders, Rieka; Ranero, Cesar R.; Weinrebe, Wilhelm; von Huene, Roland

    2014-05-01

    Subduction of kms-tall and tens-of-km wide seamounts cause important landsliding events at subduction zones around the word. Along the Middle America Trench, previous work based on regional swath bathymetry maps (with 100 m grids) and multichannel seismic images have shown that seamount subduction produces large-scale slumping and sliding. Some of the mass wasting event may have been catastrophic and numerical modeling has indicated that they may have produced important local tsunamis. We have re-evaluated the structure of several active submarine landlide complexes caused by large seamount subduction using side scan sonar data. The comparison of the side scan sonar data to local high-resolution bathymetry grids indicates that the backscatter data has a resolution that is somewhat similar to that produced by a 10 m bathymetry grid. Although this is an arbitrary comparison, the side scan sonar data provides comparatively much higher resolution information than the previously used regional multibeam bathymetry. We have mapped the geometry and relief of the head and side walls of the complexes, the distribution of scars and the different sediment deposits to produce a new interpretation of the modes of landsliding during subduction of large seamounts. The new higher resolution information shows that landsliding processes are considerably more complex than formerly assumed. Landslides are of notably smaller dimensions that the lower resolution data had previously appear to indicate. However, significantly large events may have occur far more often than earlier interpretations had inferred representing a more common threat that previously assumed.

  6. Accounting for groundwater in stream fish thermal habitat responses to climate change

    USGS Publications Warehouse

    Snyder, Craig D.; Hitt, Nathaniel P.; Young, John A.

    2015-01-01

    Forecasting climate change effects on aquatic fauna and their habitat requires an understanding of how water temperature responds to changing air temperature (i.e., thermal sensitivity). Previous efforts to forecast climate effects on brook trout habitat have generally assumed uniform air-water temperature relationships over large areas that cannot account for groundwater inputs and other processes that operate at finer spatial scales. We developed regression models that accounted for groundwater influences on thermal sensitivity from measured air-water temperature relationships within forested watersheds in eastern North America (Shenandoah National Park, USA, 78 sites in 9 watersheds). We used these reach-scale models to forecast climate change effects on stream temperature and brook trout thermal habitat, and compared our results to previous forecasts based upon large-scale models. Observed stream temperatures were generally less sensitive to air temperature than previously assumed, and we attribute this to the moderating effect of shallow groundwater inputs. Predicted groundwater temperatures from air-water regression models corresponded well to observed groundwater temperatures elsewhere in the study area. Predictions of brook trout future habitat loss derived from our fine-grained models were far less pessimistic than those from prior models developed at coarser spatial resolutions. However, our models also revealed spatial variation in thermal sensitivity within and among catchments resulting in a patchy distribution of thermally suitable habitat. Habitat fragmentation due to thermal barriers therefore may have an increasingly important role for trout population viability in headwater streams. Our results demonstrate that simple adjustments to air-water temperature regression models can provide a powerful and cost-effective approach for predicting future stream temperatures while accounting for effects of groundwater.

  7. Dynamical links between small- and large-scale mantle heterogeneity: Seismological evidence

    NASA Astrophysics Data System (ADS)

    Frost, Daniel A.; Garnero, Edward J.; Rost, Sebastian

    2018-01-01

    We identify PKP • PKP scattered waves (also known as P‧ •P‧) from earthquakes recorded at small-aperture seismic arrays at distances less than 65°. P‧ •P‧ energy travels as a PKP wave through the core, up into the mantle, then scatters back down through the core to the receiver as a second PKP. P‧ •P‧ waves are unique in that they allow scattering heterogeneities throughout the mantle to be imaged. We use array-processing methods to amplify low amplitude, coherent scattered energy signals and resolve their incoming direction. We deterministically map scattering heterogeneity locations from the core-mantle boundary to the surface. We use an extensive dataset with sensitivity to a large volume of the mantle and a location method allowing us to resolve and map more heterogeneities than have previously been possible, representing a significant increase in our understanding of small-scale structure within the mantle. Our results demonstrate that the distribution of scattering heterogeneities varies both radially and laterally. Scattering is most abundant in the uppermost and lowermost mantle, and a minimum in the mid-mantle, resembling the radial distribution of tomographically derived whole-mantle velocity heterogeneity. We investigate the spatial correlation of scattering heterogeneities with large-scale tomographic velocities, lateral velocity gradients, the locations of deep-seated hotspots and subducted slabs. In the lowermost 1500 km of the mantle, small-scale heterogeneities correlate with regions of low seismic velocity, high lateral seismic gradient, and proximity to hotspots. In the upper 1000 km of the mantle there is no significant correlation between scattering heterogeneity location and subducted slabs. Between 600 and 900 km depth, scattering heterogeneities are more common in the regions most remote from slabs, and close to hotspots. Scattering heterogeneities show an affinity for regions close to slabs within the upper 200 km of the mantle. The similarity between the distribution of large-scale and small-scale mantle structures suggests a dynamic connection across scales, whereby mantle heterogeneities of all sizes may be directed in similar ways by large-scale convective currents.

  8. A SYSTEMATIC SEARCH FOR COROTATING INTERACTION REGIONS IN APPARENTLY SINGLE GALACTIC WOLF-RAYET STARS. II. A GLOBAL VIEW OF THE WIND VARIABILITY

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chene, A.-N.; St-Louis, N., E-mail: achene@astro-udec.cl, E-mail: stlouis@astro.umontreal.ca

    This study is the second part of a survey searching for large-scale spectroscopic variability in apparently single Wolf-Rayet (WR) stars. In a previous paper (Paper I), we described and characterized the spectroscopic variability level of 25 WR stars observable from the northern hemisphere and found 3 new candidates presenting large-scale wind variability, potentially originating from large-scale structures named corotating interaction regions (CIRs). In this second paper, we discuss an additional 39 stars observable from the southern hemisphere. For each star in our sample, we obtained 4-5 high-resolution spectra with a signal-to-noise ratio of {approx}100 and determined its variability level usingmore » the approach described in Paper I. In total, 10 new stars are found to show large-scale spectral variability of which 7 present CIR-type changes (WR 8, WR 44, WR55, WR 58, WR 61, WR 63, WR 100). Of the remaining stars, 20 were found to show small-amplitude changes and 9 were found to show no spectral variability as far as can be concluded from the data on hand. Also, we discuss the spectroscopic variability level of all single galactic WR stars that are brighter than v {approx} 12.5, and some WR stars with 12.5 < v {<=} 13.5, i.e., all the stars presented in our two papers and four more stars for which spectra have already been published in the literature. We find that 23/68 stars (33.8%) present large-scale variability, but only 12/54 stars ({approx}22.1%) are potentially of CIR type. Also, we find that 31/68 stars (45.6%) only show small-scale variability, most likely due to clumping in the wind. Finally, no spectral variability is detected based on the data on hand for 14/68 (20.6%) stars. Interestingly, the variability with the highest amplitude also has the widest mean velocity dispersion.« less

  9. Genes mirror geography in Daphnia magna.

    PubMed

    Fields, Peter D; Reisser, Céline; Dukić, Marinela; Haag, Christoph R; Ebert, Dieter

    2015-09-01

    Identifying the presence and magnitude of population genetic structure remains a major consideration in evolutionary biology as doing so allows one to understand the demographic history of a species as well as make predictions of how the evolutionary process will proceed. Next-generation sequencing methods allow us to reconsider previous ideas and conclusions concerning the distribution of genetic variation, and what this distribution implies about a given species evolutionary history. A previous phylogeographic study of the crustacean Daphnia magna suggested that, despite strong genetic differentiation among populations at a local scale, the species shows only moderate genetic structure across its European range, with a spatially patchy occurrence of individual lineages. We apply RAD sequencing to a sample of D. magna collected across a wide swath of the species' Eurasian range and analyse the data using principle component analysis (PCA) of genetic variation and Procrustes analytical approaches, to quantify spatial genetic structure. We find remarkable consistency between the first two PCA axes and the geographic coordinates of individual sampling points, suggesting that, on a continent-wide scale, genetic differentiation is driven to a large extent by geographic distance. The observed pattern is consistent with unimpeded (i.e. no barriers, landscape or otherwise) migration at large spatial scales, despite the fragmented and patchy nature of favourable habitats at local scales. With high-resolution genetic data similar patterns may be uncovered for other species with wide geographic distributions, allowing an increased understanding of how genetic drift and selection have shaped their evolutionary history. © 2015 John Wiley & Sons Ltd.

  10. Fate of Large-Scale Structure in Modified Gravity After GW170817 and GRB170817A

    NASA Astrophysics Data System (ADS)

    Amendola, Luca; Kunz, Martin; Saltas, Ippocratis D.; Sawicki, Ignacy

    2018-03-01

    The coincident detection of gravitational waves (GW) and a gamma-ray burst from a merger of neutron stars has placed an extremely stringent bound on the speed of GWs. We showed previously that the presence of gravitational slip (η ) in cosmology is intimately tied to modifications of GW propagation. This new constraint implies that the only remaining viable source of gravitational slip is a conformal coupling to gravity in scalar-tensor theories, while viable vector-tensor theories cannot now generate gravitational slip at all. We discuss structure formation in the remaining viable models, demonstrating that (i) the dark-matter growth rate must now be at least as fast as in general relativity (GR), with the possible exception of that beyond the Horndeski model, and (ii) if there is any scale dependence at all in the slip parameter, it is such that it takes the GR value at large scales. We show a consistency relation that must be violated if gravity is modified.

  11. Communication: Polymer entanglement dynamics: Role of attractive interactions

    DOE PAGES

    Grest, Gary S.

    2016-10-10

    The coupled dynamics of entangled polymers, which span broad time and length scales, govern their unique viscoelastic properties. To follow chain mobility by numerical simulations from the intermediate Rouse and reptation regimes to the late time diffusive regime, highly coarse grained models with purely repulsive interactions between monomers are widely used since they are computationally the most efficient. In this paper, using large scale molecular dynamics simulations, the effect of including the attractive interaction between monomers on the dynamics of entangled polymer melts is explored for the first time over a wide temperature range. Attractive interactions have little effect onmore » the local packing for all temperatures T and on the chain mobility for T higher than about twice the glass transition T g. Finally, these results, across a broad range of molecular weight, show that to study the dynamics of entangled polymer melts, the interactions can be treated as pure repulsive, confirming a posteriori the validity of previous studies and opening the way to new large scale numerical simulations.« less

  12. Stuttering, Induced Fluency, and Natural Fluency: A Hierarchical Series of Activation Likelihood Estimation Meta-Analyses

    PubMed Central

    Budde, Kristin S.; Barron, Daniel S.; Fox, Peter T.

    2015-01-01

    Developmental stuttering is a speech disorder most likely due to a heritable form of developmental dysmyelination impairing the function of the speech-motor system. Speech-induced brain-activation patterns in persons who stutter (PWS) are anomalous in various ways; the consistency of these aberrant patterns is a matter of ongoing debate. Here, we present a hierarchical series of coordinate-based meta-analyses addressing this issue. Two tiers of meta-analyses were performed on a 17-paper dataset (202 PWS; 167 fluent controls). Four large-scale (top-tier) meta-analyses were performed, two for each subject group (PWS and controls). These analyses robustly confirmed the regional effects previously postulated as “neural signatures of stuttering” (Brown 2005) and extended this designation to additional regions. Two smaller-scale (lower-tier) meta-analyses refined the interpretation of the large-scale analyses: 1) a between-group contrast targeting differences between PWS and controls (stuttering trait); and 2) a within-group contrast (PWS only) of stuttering with induced fluency (stuttering state). PMID:25463820

  13. Large-scale structure perturbation theory without losing stream crossing

    DOE PAGES

    McDonald, Patrick; Vlah, Zvonimir

    2018-01-10

    Here, we suggest an approach to perturbative calculations of large-scale clustering in the Universe that includes from the start the stream crossing (multiple velocities for mass elements at a single position) that is lost in traditional calculations. Starting from a functional integral over displacement, the perturbative series expansion is in deviations from (truncated) Zel’dovich evolution, with terms that can be computed exactly even for stream-crossed displacements. We evaluate the one-loop formulas for displacement and density power spectra numerically in 1D, finding dramatic improvement in agreement with N-body simulations compared to the Zel’dovich power spectrum (which is exact in 1D upmore » to stream crossing). Beyond 1D, our approach could represent an improvement over previous expansions even aside from the inclusion of stream crossing, but we have not investigated this numerically. In the process we show how to achieve effective-theory-like regulation of small-scale fluctuations without free parameters.« less

  14. Large-scale structure perturbation theory without losing stream crossing

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    McDonald, Patrick; Vlah, Zvonimir

    Here, we suggest an approach to perturbative calculations of large-scale clustering in the Universe that includes from the start the stream crossing (multiple velocities for mass elements at a single position) that is lost in traditional calculations. Starting from a functional integral over displacement, the perturbative series expansion is in deviations from (truncated) Zel’dovich evolution, with terms that can be computed exactly even for stream-crossed displacements. We evaluate the one-loop formulas for displacement and density power spectra numerically in 1D, finding dramatic improvement in agreement with N-body simulations compared to the Zel’dovich power spectrum (which is exact in 1D upmore » to stream crossing). Beyond 1D, our approach could represent an improvement over previous expansions even aside from the inclusion of stream crossing, but we have not investigated this numerically. In the process we show how to achieve effective-theory-like regulation of small-scale fluctuations without free parameters.« less

  15. RELIABILITY OF THE DETECTION OF THE BARYON ACOUSTIC PEAK

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    MartInez, Vicent J.; Arnalte-Mur, Pablo; De la Cruz, Pablo

    2009-05-01

    The correlation function of the distribution of matter in the universe shows, at large scales, baryon acoustic oscillations, which were imprinted prior to recombination. This feature was first detected in the correlation function of the luminous red galaxies of the Sloan Digital Sky Survey (SDSS). Recently, the final release (DR7) of the SDSS has been made available, and the useful volume is about two times bigger than in the old sample. We present here, for the first time, the redshift-space correlation function of this sample at large scales together with that for one shallower, but denser volume-limited subsample drawn frommore » the Two-Degree Field Redshift Survey. We test the reliability of the detection of the acoustic peak at about 100 h {sup -1} Mpc and the behavior of the correlation function at larger scales by means of careful estimation of errors. We confirm the presence of the peak in the latest data although broader than in previous detections.« less

  16. Embedding Task-Based Neural Models into a Connectome-Based Model of the Cerebral Cortex.

    PubMed

    Ulloa, Antonio; Horwitz, Barry

    2016-01-01

    A number of recent efforts have used large-scale, biologically realistic, neural models to help understand the neural basis for the patterns of activity observed in both resting state and task-related functional neural imaging data. An example of the former is The Virtual Brain (TVB) software platform, which allows one to apply large-scale neural modeling in a whole brain framework. TVB provides a set of structural connectomes of the human cerebral cortex, a collection of neural processing units for each connectome node, and various forward models that can convert simulated neural activity into a variety of functional brain imaging signals. In this paper, we demonstrate how to embed a previously or newly constructed task-based large-scale neural model into the TVB platform. We tested our method on a previously constructed large-scale neural model (LSNM) of visual object processing that consisted of interconnected neural populations that represent, primary and secondary visual, inferotemporal, and prefrontal cortex. Some neural elements in the original model were "non-task-specific" (NS) neurons that served as noise generators to "task-specific" neurons that processed shapes during a delayed match-to-sample (DMS) task. We replaced the NS neurons with an anatomical TVB connectome model of the cerebral cortex comprising 998 regions of interest interconnected by white matter fiber tract weights. We embedded our LSNM of visual object processing into corresponding nodes within the TVB connectome. Reciprocal connections between TVB nodes and our task-based modules were included in this framework. We ran visual object processing simulations and showed that the TVB simulator successfully replaced the noise generation originally provided by NS neurons; i.e., the DMS tasks performed with the hybrid LSNM/TVB simulator generated equivalent neural and fMRI activity to that of the original task-based models. Additionally, we found partial agreement between the functional connectivities using the hybrid LSNM/TVB model and the original LSNM. Our framework thus presents a way to embed task-based neural models into the TVB platform, enabling a better comparison between empirical and computational data, which in turn can lead to a better understanding of how interacting neural populations give rise to human cognitive behaviors.

  17. Strengths amidst vulnerabilities: the paradox of resistance in a mining-affected community in Guatemala.

    PubMed

    Caxaj, C Susana; Berman, Helene; Ray, Susan L; Restoule, Jean-Paul; Varcoe, Coleen

    2014-11-01

    The influence of large-scale mining on the psychosocial wellbeing and mental health of diverse Indigenous communities has attracted increased attention. In previous reports, we have discussed the influence of a gold mining operation on the health of a community in the Western highlands of Guatemala. Here, we discuss the community strengths, and acts of resistance of this community, that is, community processes that promoted mental health amidst this context. Using an anti-colonial narrative methodology that incorporated participatory action research principles, we developed a research design in collaboration with community leaders and participants. Data collection involved focus groups, individual interviews and photo-sharing with 54 men and women between the ages of 18 and 67. Data analysis was guided by iterative and ongoing conversations with participants and McCormack's narrative lenses. Study findings revealed key mechanisms and sources of resistance, including a shared cultural identity, a spiritual knowing and being, 'defending our rights, defending our territory,' and, speaking truth to power. These overlapping strengths were identified by participants as key protective factors in facing challenges and adversity. Yet ultimately, these same strengths were often the most eroded or endangered due the influence of large-scale mining operations in the region. These community strengths and acts of resistance reveal important priorities for promoting mental health and wellbeing for populations impacted by large-scale mining operations. Mental health practitioners must attend to both the strengths and parallel vulnerabilities that may be occasioned by large-scale projects of this nature.

  18. Formation of outflow channels on Mars: Testing the origin of Reull Vallis in Hesperia Planum by large-scale lava-ice interactions and top-down melting

    NASA Astrophysics Data System (ADS)

    Cassanelli, James P.; Head, James W.

    2018-05-01

    The Reull Vallis outflow channel is a segmented system of fluvial valleys which originates from the volcanic plains of the Hesperia Planum region of Mars. Explanation of the formation of the Reull Vallis outflow channel by canonical catastrophic groundwater release models faces difficulties with generating sufficient hydraulic head, requiring unreasonably high aquifer permeability, and from limited recharge sources. Recent work has proposed that large-scale lava-ice interactions could serve as an alternative mechanism for outflow channel formation on the basis of predictions of regional ice sheet formation in areas that also underwent extensive contemporaneous volcanic resurfacing. Here we assess in detail the potential formation of outflow channels by large-scale lava-ice interactions through an applied case study of the Reull Vallis outflow channel system, selected for its close association with the effusive volcanic plains of the Hesperia Planum region. We first review the geomorphology of the Reull Vallis system to outline criteria that must be met by the proposed formation mechanism. We then assess local and regional lava heating and loading conditions and generate model predictions for the formation of Reull Vallis to test against the outlined geomorphic criteria. We find that successive events of large-scale lava-ice interactions that melt ice deposits, which then undergo re-deposition due to climatic mechanisms, best explains the observed geomorphic criteria, offering improvements over previously proposed formation models, particularly in the ability to supply adequate volumes of water.

  19. Three Dimensional Hybrid Simulations of Super-Alfvénic Laser Ablation Experiments in the Large Plasma Device

    NASA Astrophysics Data System (ADS)

    Clark, Stephen; Winske, Dan; Schaeffer, Derek; Everson, Erik; Bondarenko, Anton; Constantin, Carmen; Niemann, Christoph

    2014-10-01

    We present 3D hybrid simulations of laser produced expanding debris clouds propagating though a magnetized ambient plasma in the context of magnetized collisionless shocks. New results from the 3D code are compared to previously obtained simulation results using a 2D hybrid code. The 3D code is an extension of a previously developed 2D code developed at Los Alamos National Laboratory. It has been parallelized and ported to execute on a cluster environment. The new simulations are used to verify scaling relationships, such as shock onset time and coupling parameter (Rm /ρd), developed via 2D simulations. Previous 2D results focus primarily on laboratory shock formation relevant to experiments being performed on the Large Plasma Device, where the shock propagates across the magnetic field. The new 3D simulations show wave structure and dynamics oblique to the magnetic field that introduce new physics to be considered in future experiments.

  20. Large-Scale Analysis of Auditory Segregation Behavior Crowdsourced via a Smartphone App.

    PubMed

    Teki, Sundeep; Kumar, Sukhbinder; Griffiths, Timothy D

    2016-01-01

    The human auditory system is adept at detecting sound sources of interest from a complex mixture of several other simultaneous sounds. The ability to selectively attend to the speech of one speaker whilst ignoring other speakers and background noise is of vital biological significance-the capacity to make sense of complex 'auditory scenes' is significantly impaired in aging populations as well as those with hearing loss. We investigated this problem by designing a synthetic signal, termed the 'stochastic figure-ground' stimulus that captures essential aspects of complex sounds in the natural environment. Previously, we showed that under controlled laboratory conditions, young listeners sampled from the university subject pool (n = 10) performed very well in detecting targets embedded in the stochastic figure-ground signal. Here, we presented a modified version of this cocktail party paradigm as a 'game' featured in a smartphone app (The Great Brain Experiment) and obtained data from a large population with diverse demographical patterns (n = 5148). Despite differences in paradigms and experimental settings, the observed target-detection performance by users of the app was robust and consistent with our previous results from the psychophysical study. Our results highlight the potential use of smartphone apps in capturing robust large-scale auditory behavioral data from normal healthy volunteers, which can also be extended to study auditory deficits in clinical populations with hearing impairments and central auditory disorders.

  1. A large-scale study of the ultrawideband microwave dielectric properties of normal, benign and malignant breast tissues obtained from cancer surgeries

    NASA Astrophysics Data System (ADS)

    Lazebnik, Mariya; Popovic, Dijana; McCartney, Leah; Watkins, Cynthia B.; Lindstrom, Mary J.; Harter, Josephine; Sewall, Sarah; Ogilvie, Travis; Magliocco, Anthony; Breslin, Tara M.; Temple, Walley; Mew, Daphne; Booske, John H.; Okoniewski, Michal; Hagness, Susan C.

    2007-10-01

    The development of microwave breast cancer detection and treatment techniques has been driven by reports of substantial contrast in the dielectric properties of malignant and normal breast tissues. However, definitive knowledge of the dielectric properties of normal and diseased breast tissues at microwave frequencies has been limited by gaps and discrepancies across previously published studies. To address these issues, we conducted a large-scale study to experimentally determine the ultrawideband microwave dielectric properties of a variety of normal, malignant and benign breast tissues, measured from 0.5 to 20 GHz using a precision open-ended coaxial probe. Previously, we reported the dielectric properties of normal breast tissue samples obtained from reduction surgeries. Here, we report the dielectric properties of normal (adipose, glandular and fibroconnective), malignant (invasive and non-invasive ductal and lobular carcinomas) and benign (fibroadenomas and cysts) breast tissue samples obtained from cancer surgeries. We fit a one-pole Cole-Cole model to the complex permittivity data set of each characterized sample. Our analyses show that the contrast in the microwave-frequency dielectric properties between malignant and normal adipose-dominated tissues in the breast is considerable, as large as 10:1, while the contrast in the microwave-frequency dielectric properties between malignant and normal glandular/fibroconnective tissues in the breast is no more than about 10%.

  2. Parameter estimation in large-scale systems biology models: a parallel and self-adaptive cooperative strategy.

    PubMed

    Penas, David R; González, Patricia; Egea, Jose A; Doallo, Ramón; Banga, Julio R

    2017-01-21

    The development of large-scale kinetic models is one of the current key issues in computational systems biology and bioinformatics. Here we consider the problem of parameter estimation in nonlinear dynamic models. Global optimization methods can be used to solve this type of problems but the associated computational cost is very large. Moreover, many of these methods need the tuning of a number of adjustable search parameters, requiring a number of initial exploratory runs and therefore further increasing the computation times. Here we present a novel parallel method, self-adaptive cooperative enhanced scatter search (saCeSS), to accelerate the solution of this class of problems. The method is based on the scatter search optimization metaheuristic and incorporates several key new mechanisms: (i) asynchronous cooperation between parallel processes, (ii) coarse and fine-grained parallelism, and (iii) self-tuning strategies. The performance and robustness of saCeSS is illustrated by solving a set of challenging parameter estimation problems, including medium and large-scale kinetic models of the bacterium E. coli, bakerés yeast S. cerevisiae, the vinegar fly D. melanogaster, Chinese Hamster Ovary cells, and a generic signal transduction network. The results consistently show that saCeSS is a robust and efficient method, allowing very significant reduction of computation times with respect to several previous state of the art methods (from days to minutes, in several cases) even when only a small number of processors is used. The new parallel cooperative method presented here allows the solution of medium and large scale parameter estimation problems in reasonable computation times and with small hardware requirements. Further, the method includes self-tuning mechanisms which facilitate its use by non-experts. We believe that this new method can play a key role in the development of large-scale and even whole-cell dynamic models.

  3. Coronal Heating and the Magnetic Flux Content of the Network

    NASA Technical Reports Server (NTRS)

    Falconer, D. A.; Moore, R. L.; Porter, J. G.; Hathaway, D. H.; Rose, M. Franklin (Technical Monitor)

    2001-01-01

    Previously, from analysis of SOHO coronal images in combination with Kitt Peak magnetograms, we found that the quiet corona is the sum of two components: the large-scale corona and the coronal network. The large-scale corona consists of all coronal-temperature (T approximately 10(exp 6) K) structures larger than supergranules (greater than approximately 30,000 kilometers). The coronal network (1) consists of all coronal-temperature structures smaller than supergranules, (2) is rooted in and loosely traces the photospheric magnetic network, (3) has its brightest features seated on polarity dividing lines (neutral lines) in the network magnetic flux, and (4) produces only about 5% of the total coronal emission in quiet regions. The heating of the coronal network is apparently magnetic in origin. Here, from analysis of EIT coronal images of quiet regions in combination with magnetograms of the same quiet regions from SOHO/MDI and from Kitt Peak, we examine the other 95% of the quiet corona and its relation to the underlying magnetic network. We find: (1) Dividing the large-scale corona into its bright and dim halves divides the area into bright "continents" and dark "oceans" having spans of 2-4 supergranules. (2) These patterns are also present in the photospheric magnetograms: the network is stronger under the bright half and weaker under the dim half. (3) The radiation from the large-scale corona increases roughly as the cube root of the magnetic flux content of the underlying magnetic network. In contrast, the coronal radiation from an active region increases roughly linearly with the magnetic flux content of the active region. We assume, as is widely held, that nearly all of the large-scale corona is magnetically rooted in the network. Our results suggest that either the coronal heating in quiet regions has a large non-magnetic component, or, if the heating is predominantly produced via the magnetic field, the mechanism is significantly different than in active regions.

  4. Spatial and temporal variation in reef-scale carbonate storage of large benthic foraminifera: a case study on One Tree Reef

    NASA Astrophysics Data System (ADS)

    Doo, Steve S.; Hamylton, Sarah; Finfer, Joshua; Byrne, Maria

    2017-03-01

    Large benthic foraminifera (LBFs) are a vital component of coral reef carbonate production, often overlooked due to their small size. These super-abundant calcifiers are crucial to reef calcification by generation of lagoon and beach sands. Reef-scale carbonate production by LBFs is not well understood, and seasonal fluctuations in this important process are largely unquantified. The biomass of five LBF species in their algal flat habitat was quantified in the austral winter (July 2013), spring (October 2013), and summer (February 2014) at One Tree Reef. WorldView-2 satellite images were used to characterize and create LBF habitat maps based on ground-referenced photographs of algal cover. Habitat maps and LBF biomass measurements were combined to estimate carbonate storage across the entire reef flat. Total carbonate storage of LBFs on the reef flat ranged from 270 tonnes (winter) to 380 tonnes (summer). Satellite images indicate that the habitat area used by LBFs ranged from 0.6 (winter) to 0.71 km2 (spring) of a total possible area of 0.96 km2. LBF biomass was highest in the winter when algal habitat area was lowest, but total carbonate storage was the highest in the summer, when algal habitat area was intermediate. Our data suggest that biomass measurements alone do not capture total abundance of LBF populations (carbonate storage), as the area of available habitat is variable. These results suggest LBF carbonate production studies that measure biomass in discrete locations and single time points fail to capture accurate reef-scale production by not incorporating estimates of the associated algal habitat. Reef-scale measurements in this study can be incorporated into carbonate production models to determine the role of LBFs in sedimentary landforms (lagoons, beaches, etc.). Based on previous models of entire reef metabolism, our estimates indicate that LBFs contribute approximately 3.9-5.4% of reef carbonate budgets, a previously underappreciated carbon sink.

  5. Browndye: A Software Package for Brownian Dynamics

    PubMed Central

    McCammon, J. Andrew

    2010-01-01

    A new software package, Browndye, is presented for simulating the diffusional encounter of two large biological molecules. It can be used to estimate second-order rate constants and encounter probabilities, and to explore reaction trajectories. Browndye builds upon previous knowledge and algorithms from software packages such as UHBD, SDA, and Macrodox, while implementing algorithms that scale to larger systems. PMID:21132109

  6. Implications of Information Technology for Employment, Skills, and Wages: Findings from Sectoral and Case Study Research. Final Report

    ERIC Educational Resources Information Center

    Handel, Michael J.

    2004-01-01

    This paper reviews evidence from industry-specific and case studies that shed light on the extent to which computers and automation eliminate jobs, raise job skill requirements, and, consequently, contribute to increased wage inequality between less- and more skilled workers. This paper complements a previous review of large-scale econometric…

  7. Exploring Ways to Provide Diagnostic Feedback with an ESL Placement Test: Cognitive Diagnostic Assessment of L2 Reading Ability

    ERIC Educational Resources Information Center

    Kim, Ah-Young

    2015-01-01

    Previous research in cognitive diagnostic assessment (CDA) of L2 reading ability has been frequently conducted using large-scale English proficiency exams (e.g., TOEFL, MELAB). Using CDA, it is possible to analyze individual learners' strengths and weaknesses in multiple attributes (i.e., knowledge, skill, strategy) measured at the item level.…

  8. Are more complex physiological models of forest ecosystems better choices for plot and regional predictions?

    Treesearch

    Wenchi Jin; Hong S. He; Frank R. Thompson

    2016-01-01

    Process-based forest ecosystem models vary from simple physiological, complex physiological, to hybrid empirical-physiological models. Previous studies indicate that complex models provide the best prediction at plot scale with a temporal extent of less than 10 years, however, it is largely untested as to whether complex models outperform the other two types of models...

  9. Animal movement data: GPS telemetry, autocorrelation and the need for path-level analysis [chapter 7

    Treesearch

    Samuel A. Cushman

    2010-01-01

    In the previous chapter we presented the idea of a multi-layer, multi-scale, spatially referenced data-cube as the foundation for monitoring and for implementing flexible modeling of ecological pattern-process relationships in particulate, in context and to integrate these across large spatial extents at the grain of the strongest linkage between response and driving...

  10. Investigation of models for large-scale meteorological prediction experiments

    NASA Technical Reports Server (NTRS)

    Spar, J.

    1973-01-01

    Studies are reported of the long term responses of the model atmosphere to anomalies in snow cover and sea surface temperature. An abstract of a previously issued report on the computed response to surface anomalies in a global atmospheric model is presented, and the experiments on the effects of transient sea surface temperature on the Mintz-Arakawa atmospheric model are reported.

  11. Influence of winter-spring livestock grazing on survival and growth of Quercus lobata and Q. agrifolia seedlings

    Treesearch

    Claudia M. Tyler; Bruce E. Mahall; Frank W. Davis

    2008-01-01

    The relative importance of livestock grazing in limiting or enhancing oak recruitment remains unclear because results from previous studies have been contradictory. In Santa Barbara County, we have replicated large-scale planting experiments from 1997 to 2001 to determine the effects of cattle and other factors on seedling establishment of valley oak (Quercus...

  12. Body Mass Index in Adults with Intellectual Disability: Distribution, Associations and Service Implications--A Population-Based Prevalence Study

    ERIC Educational Resources Information Center

    Bhaumik, S.; Watson, J. M.; Thorp, C. F.; Tyrer, F.; McGrother, C. W.

    2008-01-01

    Background: Previous studies of weight problems in adults with intellectual disability (ID) have generally been small or selective and given conflicting results. The objectives of our large-scale study were to identify inequalities in weight problems between adults with ID and the general adult population, and to investigate factors associated…

  13. Getting Back to the Main Point: A Reply to Miller et al.

    ERIC Educational Resources Information Center

    Harrison, Allyson G.; Holmes, Alana; Silvestri, Robert; Armstrong, Irene T.

    2015-01-01

    Miller et al. have challenged the findings of our two previous studies, based largely on the assumption that our findings are biased due to the clinical sample used. However, they fail to address the primary tenet of our studies, namely, that clinicians will obtain different scores on the Wechsler Adult Intelligence Scale-IV (WAIS-IV) depending on…

  14. An Evaluation of Computerized Behavioral Skills Training to Teach Safety Skills to Young Children

    ERIC Educational Resources Information Center

    Vanselow, Nicholas R.; Hanley, Gregory P.

    2014-01-01

    Previous research has demonstrated the efficacy of behavioral skills training (BST) and in situ training (IST) for teaching children to protect themselves. However, BST may be resource intensive and difficult to implement on a large scale. We evaluated a computerized version of BST (CBST) to teach safety skills and determined the extent to which…

  15. A new scale measuring translation of the humeral head as a prognostic factor for the treatment of large and massive rotator cuff tears.

    PubMed

    Taniguchi, Noboru; D'Lima, Darryl D; Suenaga, Naoki; Chosa, Etsuo

    2018-02-01

    Failure rates after rotator cuff repair remain high in patients with massive tears. Although superior translation of the humeral head has been used to assess the severity of rotator cuff tears, the relevance of anterior migration of the humeral head to clinical outcomes has not been established. The purpose of this study was to investigate the potential role of the T-scale, a measure of the anterolateral translation of the humeral head, as a prognostic factor for rotator cuff repair. One hundred twenty consecutive patients with full-thickness rotator cuff tears underwent primary rotator cuff repair. The T-scale and acromiohumeral interval (AHI) were measured preoperatively on axial computed tomography scans and radiographs, respectively. The correlations of the T-scale and AHI with previously published scores and active forward elevation (FE) were investigated. The outcome of rotator cuff repairs was compared between patients with positive and patients with negative preoperative T-scale values. The preoperative T-scale but not AHI correlated significantly with postoperative FE and clinical scores in patients with large to massive tears but not in those with small to medium tears. Postoperative FE and clinical scores were significantly higher in patients with positive T-scale values than in those with negative T-scale values. The relative risk of retear was 2.0 to 7.9 times greater in patients with negative T-scale values. Patients with large to massive tears and negative T-scale values had poorer clinical outcomes and higher retear rates. A negative T-scale value represents a useful prognostic factor for considering reverse shoulder arthroplasty in patients at greater risk of retear after rotator cuff repair. Copyright © 2017 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Elsevier Inc. All rights reserved.

  16. How does an asymmetric magnetic field change the vertical structure of a hot accretion flow?

    NASA Astrophysics Data System (ADS)

    Samadi, M.; Abbassi, S.; Lovelace, R. V. E.

    2017-09-01

    This paper explores the effects of large-scale magnetic fields in hot accretion flows for asymmetric configurations with respect to the equatorial plane. The solutions that we have found show that the large-scale asymmetric magnetic field can significantly affect the dynamics of the flow and also cause notable outflows in the outer parts. Previously, we treated a viscous resistive accreting disc in the presence of an odd symmetric B-field about the equatorial plane. Now, we extend our earlier work by taking into account another configuration of large-scale magnetic field that is no longer symmetric. We provide asymmetric field structures with small deviations from even and odd symmetric B-field. Our results show that the disc's dynamics and appearance become different above and below the equatorial plane. The set of solutions also predicts that even a small deviation in a symmetric field causes the disc to compress on one side and expand on the other. In some cases, our solution represents a very strong outflow from just one side of the disc. Therefore, the solution may potentially explain the origin of one-sided jets in radio galaxies.

  17. Exploring the role of movement in determining the global distribution of marine biomass using a coupled hydrodynamic - Size-based ecosystem model

    NASA Astrophysics Data System (ADS)

    Watson, James R.; Stock, Charles A.; Sarmiento, Jorge L.

    2015-11-01

    Modeling the dynamics of marine populations at a global scale - from phytoplankton to fish - is necessary if we are to quantify how climate change and other broad-scale anthropogenic actions affect the supply of marine-based food. Here, we estimate the abundance and distribution of fish biomass using a simple size-based food web model coupled to simulations of global ocean physics and biogeochemistry. We focus on the spatial distribution of biomass, identifying highly productive regions - shelf seas, western boundary currents and major upwelling zones. In the absence of fishing, we estimate the total ocean fish biomass to be ∼ 2.84 ×109 tonnes, similar to previous estimates. However, this value is sensitive to the choice of parameters, and further, allowing fish to move had a profound impact on the spatial distribution of fish biomass and the structure of marine communities. In particular, when movement is implemented the viable range of large predators is greatly increased, and stunted biomass spectra characterizing large ocean regions in simulations without movement, are replaced with expanded spectra that include large predators. These results highlight the importance of considering movement in global-scale ecological models.

  18. Large-Scale Advanced Prop-Fan (LAP) pitch change actuator and control design report

    NASA Technical Reports Server (NTRS)

    Schwartz, R. A.; Carvalho, P.; Cutler, M. J.

    1986-01-01

    In recent years, considerable attention has been directed toward improving aircraft fuel consumption. Studies have shown that the high inherent efficiency previously demonstrated by low speed turboprop propulsion systems may now be extended to today's higher speed aircraft if advanced high-speed propeller blades having thin airfoils and aerodynamic sweep are utilized. Hamilton Standard has designed a 9-foot diameter single-rotation Large-Scale Advanced Prop-Fan (LAP) which will be tested on a static test stand, in a high speed wind tunnel and on a research aircraft. The major objective of this testing is to establish the structural integrity of large-scale Prop-Fans of advanced construction in addition to the evaluation of aerodynamic performance and aeroacoustic design. This report describes the operation, design features and actual hardware of the (LAP) Prop-Fan pitch control system. The pitch control system which controls blade angle and propeller speed consists of two separate assemblies. The first is the control unit which provides the hydraulic supply, speed governing and feather function for the system. The second unit is the hydro-mechanical pitch change actuator which directly changes blade angle (pitch) as scheduled by the control.

  19. Scoring best-worst data in unbalanced many-item designs, with applications to crowdsourcing semantic judgments.

    PubMed

    Hollis, Geoff

    2018-04-01

    Best-worst scaling is a judgment format in which participants are presented with a set of items and have to choose the superior and inferior items in the set. Best-worst scaling generates a large quantity of information per judgment because each judgment allows for inferences about the rank value of all unjudged items. This property of best-worst scaling makes it a promising judgment format for research in psychology and natural language processing concerned with estimating the semantic properties of tens of thousands of words. A variety of different scoring algorithms have been devised in the previous literature on best-worst scaling. However, due to problems of computational efficiency, these scoring algorithms cannot be applied efficiently to cases in which thousands of items need to be scored. New algorithms are presented here for converting responses from best-worst scaling into item scores for thousands of items (many-item scoring problems). These scoring algorithms are validated through simulation and empirical experiments, and considerations related to noise, the underlying distribution of true values, and trial design are identified that can affect the relative quality of the derived item scores. The newly introduced scoring algorithms consistently outperformed scoring algorithms used in the previous literature on scoring many-item best-worst data.

  20. Radio variability in the Phoenix Deep Survey at 1.4 GHz

    NASA Astrophysics Data System (ADS)

    Hancock, P. J.; Drury, J. A.; Bell, M. E.; Murphy, T.; Gaensler, B. M.

    2016-09-01

    We use archival data from the Phoenix Deep Survey to investigate the variable radio source population above 1 mJy beam-1 at 1.4 GHz. Given the similarity of this survey to other such surveys we take the opportunity to investigate the conflicting results which have appeared in the literature. Two previous surveys for variability conducted with the Very Large Array (VLA) achieved a sensitivity of 1 mJy beam-1. However, one survey found an areal density of radio variables on time-scales of decades that is a factor of ˜4 times greater than a second survey which was conducted on time-scales of less than a few years. In the Phoenix deep field we measure the density of variable radio sources to be ρ = 0.98 deg-2 on time-scales of 6 months to 8 yr. We make use of Wide-field Infrared Survey Explorer infrared cross-ids, and identify all variable sources as an active galactic nucleus of some description. We suggest that the discrepancy between previous VLA results is due to the different time-scales probed by each of the surveys, and that radio variability at 1.4 GHz is greatest on time-scales of 2-5 yr.

  1. Hind limb scaling of kangaroos and wallabies (superfamily Macropodoidea): implications for hopping performance, safety factor and elastic savings

    PubMed Central

    McGowan, C P; Skinner, J; Biewener, A A

    2008-01-01

    The aim of this study was to examine hind limb scaling of the musculoskeletal system in the Macropodoidea, the superfamily containing wallabies and kangaroos, to re-examine the effect of size on the locomotor mechanics and physiology of marsupial hopping. Morphometric musculoskeletal analyses were conducted of 15 species and skeletal specimens of 21 species spanning a size range from 0.8 to 80 kg that included representatives of 12 of the 16 extant genera of macropodoids. We found that unlike other groups, macropodoids are able to match force demands associated with increasing body size primarily through a combination of positive allometry in muscle area and muscle moment arms. Isometric scaling of primary hind limb bones suggests, however, that larger species experience relatively greater bone stresses. Muscle to tendon area ratios of the ankle extensors scale with strong positive allometry, indicating that peak tendon stresses also increase with increasing body size but to a lesser degree than previously reported. Consistent with previous morphological and experimental studies, large macropodoids are therefore better suited for elastic strain energy recovery but operate at lower safety factors, which likely poses an upper limit to body size. Scaling patterns for extant macropodoids suggest that extinct giant kangaroos (∼250 kg) were likely limited in locomotor capacity. PMID:18086129

  2. Dynamics of Large-Scale Solar-Wind Streams Obtained by the Double Superposed Epoch Analysis: 2. Comparisons of CIRs vs. Sheaths and MCs vs. Ejecta

    NASA Astrophysics Data System (ADS)

    Yermolaev, Y. I.; Lodkina, I. G.; Nikolaeva, N. S.; Yermolaev, M. Y.

    2017-12-01

    This work is a continuation of our previous article (Yermolaev et al. in J. Geophys. Res. 120, 7094, 2015), which describes the average temporal profiles of interplanetary plasma and field parameters in large-scale solar-wind (SW) streams: corotating interaction regions (CIRs), interplanetary coronal mass ejections (ICMEs including both magnetic clouds (MCs) and ejecta), and sheaths as well as interplanetary shocks (ISs). As in the previous article, we use the data of the OMNI database, our catalog of large-scale solar-wind phenomena during 1976 - 2000 (Yermolaev et al. in Cosmic Res., 47, 2, 81, 2009) and the method of double superposed epoch analysis (Yermolaev et al. in Ann. Geophys., 28, 2177, 2010a). We rescale the duration of all types of structures in such a way that the beginnings and endings for all of them coincide. We present new detailed results comparing pair phenomena: 1) both types of compression regions ( i.e. CIRs vs. sheaths) and 2) both types of ICMEs (MCs vs. ejecta). The obtained data allow us to suggest that the formation of the two types of compression regions responds to the same physical mechanism, regardless of the type of piston (high-speed stream (HSS) or ICME); the differences are connected to the geometry ( i.e. the angle between the speed gradient in front of the piston and the satellite trajectory) and the jumps in speed at the edges of the compression regions. In our opinion, one of the possible reasons behind the observed differences in the parameters in MCs and ejecta is that when ejecta are observed, the satellite passes farther from the nose of the area of ICME than when MCs are observed.

  3. Numerical Technology for Large-Scale Computational Electromagnetics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sharpe, R; Champagne, N; White, D

    The key bottleneck of implicit computational electromagnetics tools for large complex geometries is the solution of the resulting linear system of equations. The goal of this effort was to research and develop critical numerical technology that alleviates this bottleneck for large-scale computational electromagnetics (CEM). The mathematical operators and numerical formulations used in this arena of CEM yield linear equations that are complex valued, unstructured, and indefinite. Also, simultaneously applying multiple mathematical modeling formulations to different portions of a complex problem (hybrid formulations) results in a mixed structure linear system, further increasing the computational difficulty. Typically, these hybrid linear systems aremore » solved using a direct solution method, which was acceptable for Cray-class machines but does not scale adequately for ASCI-class machines. Additionally, LLNL's previously existing linear solvers were not well suited for the linear systems that are created by hybrid implicit CEM codes. Hence, a new approach was required to make effective use of ASCI-class computing platforms and to enable the next generation design capabilities. Multiple approaches were investigated, including the latest sparse-direct methods developed by our ASCI collaborators. In addition, approaches that combine domain decomposition (or matrix partitioning) with general-purpose iterative methods and special purpose pre-conditioners were investigated. Special-purpose pre-conditioners that take advantage of the structure of the matrix were adapted and developed based on intimate knowledge of the matrix properties. Finally, new operator formulations were developed that radically improve the conditioning of the resulting linear systems thus greatly reducing solution time. The goal was to enable the solution of CEM problems that are 10 to 100 times larger than our previous capability.« less

  4. Full particle simulations of short large-amplitude magnetic structures (SLAMS) in quasi-parallel shocks

    NASA Astrophysics Data System (ADS)

    Tsubouchi, K.; LembèGe, B.

    2004-02-01

    Dynamics of SLAMS (short large-amplitude magnetic structures) is investigated by the use of one-dimensional, full particle electromagnetic simulations. As previous hybrid simulations and analysis of experimental observations suggested, present results confirm that the SLAMS patterns result from the steepening of long wavelength magnetosonic waves which are excited by diffuse ions (representing the field-aligned reflected ion beam) interacting with the upstream ambient plasma. Five successive phases have been identified in the SLAMS dynamics: ULF wave growth and symmetric, asymmetric, spiky, and late SLAMS. The present accessibility to high-resolution (electron) scales leads to the following new features: (1) the leading edge of the SLAMS steepens over a spatial scale from which a large-amplitude whistler precursor is emitted; (2) this whistler departs from the SLAMS edge and behaves as a new shock front; (3) the spiky SLAMS phase is characterized by the build-up of a strong spiky electrostatic field (its width is about 0.5 ion inertial length) within the whistler precursor and is intermittent with a lifetime less than one inverse ion gyroperiod; (4) the new shock front suffers a local self-reformation typical of a quasi-perpendicular shock in supercritical regime during the late-SLAMS phase. The features of the spiky SLAMS phase can be used as a typical signature in the time history of the SLAMS dynamics. Spatial/time scales of SLAMS have been measured throughout the different phases and are found in good agreement with results issued from previous hybrid simulations and with experimental measurements made by AMPTE UKS/IRM satellites; these are also compared with recent results from Cluster-2 space mission.

  5. Eastern Ishtar Terra: Tectonic evolution derived from recognized features

    NASA Technical Reports Server (NTRS)

    Vorderbruegge, R. W.; Head, James W.

    1989-01-01

    Previous analyses have recognized several styles and orientations of compressional deformation, crustal convergence, and crustal thickening in Eastern Ishtar Terra. An east to west sense of crustal convergence through small scale folding, thrusting, and buckling is reflected in the high topography and ridge-and-valley morphology of Maxwell Montes and the adjacent portion of Fortuna Tessera. This east to west convergence was accompanied by up to 1000 km of lateral motion and large scale strike-slip faulting within two converging shear zones which has resulted in the present morphology of Maxwell Montes. A more northeast to southwest sense of convergence through large scale buckling and imbrication is reflected in large, northwest-trending scarps along the entire northern boundary of Ishtar Terra, with up to 2 km of relief present at many of the scarps. It was previously suggested that both styles of compression have occurred at the expense of pre-existing tessera regions which have then been overprinted by the latest convergence event. The difference in style is attributed mostly to differences in the properties of the crust converging with the tessera blocks. If one, presumably thick, tessera block converges with another tessera region, then the widespread, distributed style of deformation occurs, as observed in western Fortuna Tessera. However, if relatively thin crust (such as suggested for the North Polar Plains converges with thicker tessera regions, then localized deformation occurs, as reflected in the scarps along Northern Ishtar Terra. The purpose is to identify the types of features observed in Eastern Ishtar Terra. Their potential temporal and spatial relationships, is described, possible origins for them is suggested, and how the interpretation of some of these features has led to the multiple-style tectonic evolution model described is shown.

  6. Semantic Differential Scale Method Can Reveal Multi-Dimensional Aspects of Mind Perception.

    PubMed

    Takahashi, Hideyuki; Ban, Midori; Asada, Minoru

    2016-01-01

    As humans, we tend to perceive minds in both living and non-living entities, such as robots. From a questionnaire developed in a previous mind perception study, authors found that perceived minds could be located on two dimensions "experience" and "agency." This questionnaire allowed the assessment of how we perceive minds of various entities from a multi-dimensional point of view. In this questionnaire, subjects had to evaluate explicit mental capacities of target characters (e.g., capacity to feel hunger). However, we sometimes perceive minds in non-living entities, even though we cannot attribute these evidently biological capacities to the entity. In this study, we performed a large-scale web survey to assess mind perception by using the semantic differential scale method. We revealed that two mind dimensions "emotion" and "intelligence," respectively, corresponded to the two mind dimensions (experience and agency) proposed in a previous mind perception study. We did this without having to ask about specific mental capacities. We believe that the semantic differential scale is a useful method to assess the dimensions of mind perception especially for non-living entities that are hard to be attributed to biological capacities.

  7. Cartographic experiment for Latin America. [Santa Cruz, Bolivia and Concepcion, Paraguay

    NASA Technical Reports Server (NTRS)

    Staples, J. E. (Principal Investigator)

    1974-01-01

    The author has identified the following significant results. The two experiments clearly demonstrate the practical application of the Skylab photography to update existing maps at an optimum scale of 1:100,000. The photography can even be used, by employing first order photogrammetric instruments, for updating the cultural features in 1:50,000 scale mapping. The S190A imagery has also shown itself to be most economical in preparing new photomap products over previously unmapped areas, such as Concepcion, Paraguay. These maps indicate that Skylab quality imagery is invaluable to the Latin American cartographers in their efforts to provide the mapping products required to develop their countries. In Latin America, where over 5,000 people are employed in map production and where the Latin American governments are expending over $20 million in this effort, the use of such systems to maintain existing mapping and publish new mapping over previously unmapped areas, is of great economic value and could release the conventional Latin American mapping resources to be utilized to produce large scale 1:25,000 and 1:1,000 scale mapping that is needed for specific development projects.

  8. Global Distribution of Extreme Precipitation and High-Impact Landslides in 2010 Relative to Previous Years

    NASA Technical Reports Server (NTRS)

    Kirschbaum, Dalia; Adler, Robert; Adler, David; Peters-Lidard, Christa; Huffman, George

    2012-01-01

    It is well known that extreme or prolonged rainfall is the dominant trigger of landslides worldwide. While research has evaluated the spatiotemporal distribution of extreme rainfall and landslides at local or regional scales using in situ data, few studies have mapped rainfall-triggered landslide distribution globally due to the dearth of landslide data and consistent precipitation information. This study uses a newly developed Global Landslide Catalog (GLC) and a 13-year satellite-based precipitation record from TRMM data. For the first time, these two unique products provide the foundation to quantitatively evaluate the co-occurrence of precipitation and landslides globally. Evaluation of the GLC indicates that 2010 had a large number of high-impact landslide events relative to previous years. This study considers how variations in extreme and prolonged satellite-based rainfall are related to the distribution of landslides over the same time scales for three active landslide areas: Central America, the Himalayan Arc, and central-eastern China. Several test statistics confirm that TRMM rainfall generally scales with the observed increase in landslide reports and fatal events for 2010 and previous years over each region. These findings suggest that the co-occurrence of satellite precipitation and landslide reports may serve as a valuable indicator for characterizing the spatiotemporal distribution of landslide-prone areas in order to establish a global rainfall-triggered landslide climatology. This study characterizes the variability of satellite precipitation data and reported landslide activity at the globally scale in order to improve landslide cataloging, forecasting and quantify potential triggering sources at daily, monthly and yearly time scales.

  9. Extreme Precipitation and High-Impact Landslides

    NASA Technical Reports Server (NTRS)

    Kirschbaum, Dalia; Adler, Robert; Huffman, George; Peters-Lidard, Christa

    2012-01-01

    It is well known that extreme or prolonged rainfall is the dominant trigger of landslides; however, there remain large uncertainties in characterizing the distribution of these hazards and meteorological triggers at the global scale. Researchers have evaluated the spatiotemporal distribution of extreme rainfall and landslides at local and regional scale primarily using in situ data, yet few studies have mapped rainfall-triggered landslide distribution globally due to the dearth of landslide data and consistent precipitation information. This research uses a newly developed Global Landslide Catalog (GLC) and a 13-year satellite-based precipitation record from Tropical Rainfall Measuring Mission (TRMM) data. For the first time, these two unique products provide the foundation to quantitatively evaluate the co-occurence of precipitation and rainfall-triggered landslides globally. The GLC, available from 2007 to the present, contains information on reported rainfall-triggered landslide events around the world using online media reports, disaster databases, etc. When evaluating this database, we observed that 2010 had a large number of high-impact landslide events relative to previous years. This study considers how variations in extreme and prolonged satellite-based rainfall are related to the distribution of landslides over the same time scales for three active landslide areas: Central America, the Himalayan Arc, and central-eastern China. Several test statistics confirm that TRMM rainfall generally scales with the observed increase in landslide reports and fatal events for 2010 and previous years over each region. These findings suggest that the co-occurrence of satellite precipitation and landslide reports may serve as a valuable indicator for characterizing the spatiotemporal distribution of landslide-prone areas in order to establish a global rainfall-triggered landslide climatology. This research also considers the sources for this extreme rainfall, citing teleconnections from ENSO as likely contributors to regional precipitation variability. This work demonstrates the potential for using satellite-based precipitation estimates to identify potentially active landslide areas at the global scale in order to improve landslide cataloging and quantify landslide triggering at daily, monthly and yearly time scales.

  10. High-Frequency Observations of Temperature and Dissolved Oxygen Reveal Under-Ice Convection in a Large Lake

    NASA Astrophysics Data System (ADS)

    Yang, Bernard; Young, Joelle; Brown, Laura; Wells, Mathew

    2017-12-01

    Detailed observations of thermal structure over an entire winter in a large lake reveal the presence of large (10-20 m) overturns under the ice, driven by diurnal solar heating. Convection can occur in the early winter, but the most vigorous convection occurred near the end of winter. Both periods are when our lake ice model suggest thinner ice that would have been transparent. This under-ice convection led to a deepening of the mixed layer over time, consistent with previous short-term studies. During periods of vigorous convection under the ice at the end of winter, the dissolved oxygen had become supersaturated from the surface to 23 m below the surface, suggesting abundant algal growth. Analysis of our high-frequency observations over the entire winter of 2015 using the Thorpe-scale method quantified the scale of mixing. Furthermore, it revealed that changes in oxygen concentrations are closely related to the intensity of mixing.

  11. Study of the Unsteady Flow Features on a Stalled Wing

    NASA Technical Reports Server (NTRS)

    Yon, Steven A.; Katz, Joseph

    1997-01-01

    The occurrence of large scale structures in the post stall flow over a rectangular wing at high angles of attack was investigated in a small-scale subsonic wind tunnel. Mean and time dependent measurements within the separated flow field suggest the existence of two distinct angle of attack regimes beyond wing stall. The shallow stall regime occurs over a narrow range of incidence angles (2-3 deg.) immediately following the inception of leading edge separation. In this regime, the principal mean flow structures, termed stall cells, are manifested as a distinct spanwise periodicity in the chordwise extent of the separated region on the model surface with possible lateral mobility not previously reported. Within the stall cells and on the wing surface, large amplitude pressure fluctuations occur with a frequency much lower than anticipated for bluff body shedding, and with minimum effect in the far wake. In the deep stall regime, stall cells are not observed and the separated region near the model is relatively free of large amplitude pressure disturbances.

  12. Updates to WFC3/UVIS Filter-Dependent and Filter-Distinct Distortion Corrections

    NASA Astrophysics Data System (ADS)

    Martlin, Catherine; Kozhurina-Platais, Vera; McKay, Myles; Sabbi, Elena

    2018-06-01

    The WFC3/UVIS filter wheel contains 63 filters that cover a large range of wavelengths from near ultraviolet to the near infrared. Previously, analysis was completed on the 14 most used UVIS filters to calibrate geometric distortions. These distortions are due to a combination of the optical assembly of HST as well as the variabilities in the composition of individual filters. We report recent updates to reference files that aid in correcting for these distortions of an additional 22 UVIS narrow and medium band filters and 4 unique UVIS filters. They were created following a calibration of the large-scale optical distortions and fine-scale filter-dependent distortions. Furthermore, we present results on a study into a selection of unique polynomial coefficient terms from all solved filters which allows us to better investigate the filter-dependent patterns across a large range of wavelengths.These updates will provide important enhancements for HST/WFC3 users as they allow more accurate alignment of images across the range of UVIS filters.

  13. Observational and modeling studies of heat, moisture, precipitation, and global-scale circulation patterns

    NASA Technical Reports Server (NTRS)

    Vincent, Dayton G.; Robertson, Franklin

    1993-01-01

    The research sponsored by this grant is a continuation and an extension of the work conducted under a previous contract, 'South Pacific Convergence Zone and Global-Scale Circulations'. In the prior work, we conducted a detailed investigation of the South Pacific convergence zone (SPCZ), and documented many of its significant features and characteristics. We also conducted studies of its interaction with global-scale circulation features through the use of both observational and modeling studies. The latter was accomplished toward the end of the contract when Dr. James Hurrell, then a Ph.D. candidate, successfully ported the NASA GLA general circulation model (GCM) to Purdue University. In our present grant, we have expanded our previous research to include studies of other convectively-driven circulation systems in the tropics besides the SPCZ. Furthermore, we have continued to examine the relationship between these convective systems and global-scale circulation patterns. Our recent research efforts have focused on three objectives: (1) determining the periodicity of large-scale bands of organized convection in the tropics, primarily synoptic to intraseasonal time scales in the Southern Hemisphere; (2) examining the relative importance of tropical versus mid-latitude forcing for Southern Hemisphere summertime subtropical jets, particularly over the Pacific Ocean; and (3) estimating tropical precipitation, especially over oceans, using observational and budget methods. A summary list of our most significant accomplishments in the past year is given.

  14. Large-Scale, High-Resolution Neurophysiological Maps Underlying fMRI of Macaque Temporal Lobe

    PubMed Central

    Papanastassiou, Alex M.; DiCarlo, James J.

    2013-01-01

    Maps obtained by functional magnetic resonance imaging (fMRI) are thought to reflect the underlying spatial layout of neural activity. However, previous studies have not been able to directly compare fMRI maps to high-resolution neurophysiological maps, particularly in higher level visual areas. Here, we used a novel stereo microfocal x-ray system to localize thousands of neural recordings across monkey inferior temporal cortex (IT), construct large-scale maps of neuronal object selectivity at subvoxel resolution, and compare those neurophysiology maps with fMRI maps from the same subjects. While neurophysiology maps contained reliable structure at the sub-millimeter scale, fMRI maps of object selectivity contained information at larger scales (>2.5 mm) and were only partly correlated with raw neurophysiology maps collected in the same subjects. However, spatial smoothing of neurophysiology maps more than doubled that correlation, while a variety of alternative transforms led to no significant improvement. Furthermore, raw spiking signals, once spatially smoothed, were as predictive of fMRI maps as local field potential signals. Thus, fMRI of the inferior temporal lobe reflects a spatially low-passed version of neurophysiology signals. These findings strongly validate the widespread use of fMRI for detecting large (>2.5 mm) neuronal domains of object selectivity but show that a complete understanding of even the most pure domains (e.g., faces vs nonface objects) requires investigation at fine scales that can currently only be obtained with invasive neurophysiological methods. PMID:24048850

  15. Effect of nacelle on wake meandering in a laboratory scale wind turbine using LES

    NASA Astrophysics Data System (ADS)

    Foti, Daniel; Yang, Xiaolei; Guala, Michele; Sotiropoulos, Fotis

    2015-11-01

    Wake meandering, large scale motion in the wind turbine wakes, has considerable effects on the velocity deficit and turbulence intensity in the turbine wake from the laboratory scale to utility scale wind turbines. In the dynamic wake meandering model, the wake meandering is assumed to be caused by large-scale atmospheric turbulence. On the other hand, Kang et al. (J. Fluid Mech., 2014) demonstrated that the nacelle geometry has a significant effect on the wake meandering of a hydrokinetic turbine, through the interaction of the inner wake of the nacelle vortex with the outer wake of the tip vortices. In this work, the significance of the nacelle on the wake meandering of a miniature wind turbine previously used in experiments (Howard et al., Phys. Fluid, 2015) is demonstrated with large eddy simulations (LES) using immersed boundary method with fine enough grids to resolve the turbine geometric characteristics. The three dimensionality of the wake meandering is analyzed in detail through turbulent spectra and meander reconstruction. The computed flow fields exhibit wake dynamics similar to those observed in the wind tunnel experiments and are analyzed to shed new light into the role of the energetic nacelle vortex on wake meandering. This work was supported by Department of Energy DOE (DE-EE0002980, DE-EE0005482 and DE-AC04-94AL85000), and Sandia National Laboratories. Computational resources were provided by Sandia National Laboratories and the University of Minnesota Supercomputing.

  16. Geometric quantification of features in large flow fields.

    PubMed

    Kendall, Wesley; Huang, Jian; Peterka, Tom

    2012-01-01

    Interactive exploration of flow features in large-scale 3D unsteady-flow data is one of the most challenging visualization problems today. To comprehensively explore the complex feature spaces in these datasets, a proposed system employs a scalable framework for investigating a multitude of characteristics from traced field lines. This capability supports the examination of various neighborhood-based geometric attributes in concert with other scalar quantities. Such an analysis wasn't previously possible because of the large computational overhead and I/O requirements. The system integrates visual analytics methods by letting users procedurally and interactively describe and extract high-level flow features. An exploration of various phenomena in a large global ocean-modeling simulation demonstrates the approach's generality and expressiveness as well as its efficacy.

  17. Advancing the speed, sensitivity and accuracy of biomolecular detection using multi-length-scale engineering

    PubMed Central

    Kelley, Shana O.; Mirkin, Chad A.; Walt, David R.; Ismagilov, Rustem F.; Toner, Mehmet; Sargent, Edward H.

    2015-01-01

    Rapid progress in identifying disease biomarkers has increased the importance of creating high-performance detection technologies. Over the last decade, the design of many detection platforms has focused on either the nano or micro length scale. Here, we review recent strategies that combine nano- and microscale materials and devices to produce large improvements in detection sensitivity, speed and accuracy, allowing previously undetectable biomarkers to be identified in clinical samples. Microsensors that incorporate nanoscale features can now rapidly detect disease-related nucleic acids expressed in patient samples. New microdevices that separate large clinical samples into nanocompartments allow precise quantitation of analytes, and microfluidic systems that utilize nanoscale binding events can detect rare cancer cells in the bloodstream more accurately than before. These advances will lead to faster and more reliable clinical diagnostic devices. PMID:25466541

  18. Advancing the speed, sensitivity and accuracy of biomolecular detection using multi-length-scale engineering

    NASA Astrophysics Data System (ADS)

    Kelley, Shana O.; Mirkin, Chad A.; Walt, David R.; Ismagilov, Rustem F.; Toner, Mehmet; Sargent, Edward H.

    2014-12-01

    Rapid progress in identifying disease biomarkers has increased the importance of creating high-performance detection technologies. Over the last decade, the design of many detection platforms has focused on either the nano or micro length scale. Here, we review recent strategies that combine nano- and microscale materials and devices to produce large improvements in detection sensitivity, speed and accuracy, allowing previously undetectable biomarkers to be identified in clinical samples. Microsensors that incorporate nanoscale features can now rapidly detect disease-related nucleic acids expressed in patient samples. New microdevices that separate large clinical samples into nanocompartments allow precise quantitation of analytes, and microfluidic systems that utilize nanoscale binding events can detect rare cancer cells in the bloodstream more accurately than before. These advances will lead to faster and more reliable clinical diagnostic devices.

  19. Large-Scale Astrophysical Visualization on Smartphones

    NASA Astrophysics Data System (ADS)

    Becciani, U.; Massimino, P.; Costa, A.; Gheller, C.; Grillo, A.; Krokos, M.; Petta, C.

    2011-07-01

    Nowadays digital sky surveys and long-duration, high-resolution numerical simulations using high performance computing and grid systems produce multidimensional astrophysical datasets in the order of several Petabytes. Sharing visualizations of such datasets within communities and collaborating research groups is of paramount importance for disseminating results and advancing astrophysical research. Moreover educational and public outreach programs can benefit greatly from novel ways of presenting these datasets by promoting understanding of complex astrophysical processes, e.g., formation of stars and galaxies. We have previously developed VisIVO Server, a grid-enabled platform for high-performance large-scale astrophysical visualization. This article reviews the latest developments on VisIVO Web, a custom designed web portal wrapped around VisIVO Server, then introduces VisIVO Smartphone, a gateway connecting VisIVO Web and data repositories for mobile astrophysical visualization. We discuss current work and summarize future developments.

  20. Flexible Redistribution in Cognitive Networks.

    PubMed

    Hartwigsen, Gesa

    2018-06-15

    Previous work has emphasized that cognitive functions in the human brain are organized into large-scale networks. However, the mechanisms that allow these networks to compensate for focal disruptions remain elusive. I suggest a new perspective on the compensatory flexibility of cognitive networks. First, I demonstrate that cognitive networks can rapidly change the functional weight of the relative contribution of different regions. Second, I argue that there is an asymmetry in the compensatory potential of different kinds of networks. Specifically, recruitment of domain-general functions can partially compensate for focal disruptions of specialized cognitive functions, but not vice versa. Considering the compensatory potential within and across networks will increase our understanding of functional adaptation and reorganization after brain lesions and offers a new perspective on large-scale neural network (re-)organization. Copyright © 2018 Elsevier Ltd. All rights reserved.

  1. Development of Solvent Extraction Approach to Recycle Enriched Molybdenum Material

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tkac, Peter; Brown, M. Alex; Sen, Sujat

    2016-06-01

    Argonne National Laboratory, in cooperation with Oak Ridge National Laboratory and NorthStar Medical Technologies, LLC, is developing a recycling process for a solution containing valuable Mo-100 or Mo-98 enriched material. Previously, Argonne had developed a recycle process using a precipitation technique. However, this process is labor intensive and can lead to production of large volumes of highly corrosive waste. This report discusses an alternative process to recover enriched Mo in the form of ammonium heptamolybdate by using solvent extraction. Small-scale experiments determined the optimal conditions for effective extraction of high Mo concentrations. Methods were developed for removal of ammonium chloridemore » from the molybdenum product of the solvent extraction process. In large-scale experiments, very good purification from potassium and other elements was observed with very high recovery yields (~98%).« less

  2. The evolving magnetic topology of τ Boötis

    NASA Astrophysics Data System (ADS)

    Mengel, M. W.; Fares, R.; Marsden, S. C.; Carter, B. D.; Jeffers, S. V.; Petit, P.; Donati, J.-F.; Folsom, C. P.; BCool Collaboration

    2016-07-01

    We present six epochs of spectropolarimetric observations of the hot-Jupiter-hosting star τ Boötis that extend the exceptional previous multiyear data set of its large-scale magnetic field. Our results confirm that the large-scale magnetic field of τ Boötis varies cyclicly, with the observation of two further magnetic reversals; between 2013 December and 2014 May and between 2015 January and March. We also show that the field evolves in a broadly solar-type manner in contrast to other F-type stars. We further present new results which indicate that the chromospheric activity cycle and the magnetic activity cycles are related, which would indicate a very rapid magnetic cycle. As an exemplar of long-term magnetic field evolution, τ Boötis and this long-term monitoring campaign presents a unique opportunity for studying stellar magnetic cycles.

  3. Problems in merging Earth sensing satellite data sets

    NASA Technical Reports Server (NTRS)

    Smith, Paul H.; Goldberg, Michael J.

    1987-01-01

    Satellite remote sensing systems provide a tremendous source of data flow to the Earth science community. These systems provide scientists with data of types and on a scale previously unattainable. Looking forward to the capabilities of Space Station and the Earth Observing System (EOS), the full realization of the potential of satellite remote sensing will be handicapped by inadequate information systems. There is a growing emphasis in Earth science research to ask questions which are multidisciplinary in nature and global in scale. Many of these research projects emphasize the interactions of the land surface, the atmosphere, and the oceans through various physical mechanisms. Conducting this research requires large and complex data sets and teams of multidisciplinary scientists, often working at remote locations. A review of the problems of merging these large volumes of data into spatially referenced and manageable data sets is presented.

  4. Inferring field-scale properties of a fractured aquifer from ground surface deformation during a well test

    NASA Astrophysics Data System (ADS)

    Schuite, Jonathan; Longuevergne, Laurent; Bour, Olivier; Boudin, Frédérick; Durand, Stéphane; Lavenant, Nicolas

    2015-12-01

    Fractured aquifers which bear valuable water resources are often difficult to characterize with classical hydrogeological tools due to their intrinsic heterogeneities. Here we implement ground surface deformation tools (tiltmetry and optical leveling) to monitor groundwater pressure changes induced by a classical hydraulic test at the Ploemeur observatory. By jointly analyzing complementary time constraining data (tilt) and spatially constraining data (vertical displacement), our results strongly suggest that the use of these surface deformation observations allows for estimating storativity and structural properties (dip, root depth, and lateral extension) of a large hydraulically active fracture, in good agreement with previous studies. Hence, we demonstrate that ground surface deformation is a useful addition to traditional hydrogeological techniques and opens possibilities for characterizing important large-scale properties of fractured aquifers with short-term well tests as a controlled forcing.

  5. Vertically migrating swimmers generate aggregation-scale eddies in a stratified column.

    PubMed

    Houghton, Isabel A; Koseff, Jeffrey R; Monismith, Stephen G; Dabiri, John O

    2018-04-01

    Biologically generated turbulence has been proposed as an important contributor to nutrient transport and ocean mixing 1-3 . However, to produce non-negligible transport and mixing, such turbulence must produce eddies at scales comparable to the length scales of stratification in the ocean. It has previously been argued that biologically generated turbulence is limited to the scale of the individual animals involved 4 , which would make turbulence created by highly abundant centimetre-scale zooplankton such as krill irrelevant to ocean mixing. Their small size notwithstanding, zooplankton form dense aggregations tens of metres in vertical extent as they undergo diurnal vertical migration over hundreds of metres 3,5,6 . This behaviour potentially introduces additional length scales-such as the scale of the aggregation-that are of relevance to animal interactions with the surrounding water column. Here we show that the collective vertical migration of centimetre-scale swimmers-as represented by the brine shrimp Artemia salina-generates aggregation-scale eddies that mix a stable density stratification, resulting in an effective turbulent diffusivity up to three orders of magnitude larger than the molecular diffusivity of salt. These observed large-scale mixing eddies are the result of flow in the wakes of the individual organisms coalescing to form a large-scale downward jet during upward swimming, even in the presence of a strong density stratification relative to typical values observed in the ocean. The results illustrate the potential for marine zooplankton to considerably alter the physical and biogeochemical structure of the water column, with potentially widespread effects owing to their high abundance in climatically important regions of the ocean 7 .

  6. Study of alumina-trichite reinforcement of a nickel-based matric by means of powder metallurgy

    NASA Technical Reports Server (NTRS)

    Walder, A.; Hivert, A.

    1982-01-01

    Research was conducted on reinforcing nickel based matrices with alumina trichites by using powder metallurgy. Alumina trichites previously coated with nickel are magnetically aligned. The felt obtained is then sintered under a light pressure at a temperature just below the melting point of nickel. The halogenated atmosphere technique makes it possible to incorporate a large number of additive elements such as chromium, titanium, zirconium, tantalum, niobium, aluminum, etc. It does not appear that going from laboratory scale to a semi-industrial scale in production would create any major problems.

  7. Experiment-scale molecular simulation study of liquid crystal thin films

    NASA Astrophysics Data System (ADS)

    Nguyen, Trung Dac; Carrillo, Jan-Michael Y.; Matheson, Michael A.; Brown, W. Michael

    2014-03-01

    Supercomputers have now reached a performance level adequate for studying thin films with molecular detail at the relevant scales. By exploiting the power of GPU accelerators on Titan, we have been able to perform simulations of characteristic liquid crystal films that provide remarkable qualitative agreement with experimental images. We have demonstrated that key features of spinodal instability can only be observed with sufficiently large system sizes, which were not accessible with previous simulation studies. Our study emphasizes the capability and significance of petascale simulations in providing molecular-level insights in thin film systems as well as other interfacial phenomena.

  8. Externally-blown-flap noise

    NASA Technical Reports Server (NTRS)

    Dorsch, R. G.; Kreim, W. J.; Olsen, W. A.

    1972-01-01

    Noise data were obtained with a large externally blown flap model. A fan-jet engine exhaust was simulated by a 1/2-scale bypass nozzle supplied by pressurized air. The nozzle was pylon mounted on a wing section having a double-slotted flap for lift augmentation. Noise radiation patterns and spectra were obtained for nozzle exhaust velocities between 400 and 1150 ft/sec. The blown flap noise data are in good agreement with previous small model results extrapolated to test conditions by Strouhal scaling. The results indicate that blown flap noise must be suppressed to meet STOL aircraft noise goals.

  9. The life cycles of intense cyclonic and anticyclonic circulation systems observed over oceans

    NASA Technical Reports Server (NTRS)

    Smith, Phillip J.

    1993-01-01

    Full attention was now directed to the blocking case studies mentioned in previous reports. Coding and initial computational tests were completed for a North Atlantic blocking case that occurred in late October/early November 1985 and an upstream cyclone that developed rapidly 24 hours before block onset. This work is the subject of two papers accepted for presentation at the International Symposium on the Lifecycles of Extratropical Cyclones in Bergen, Norway, 27 June - 1 July 1994. This effort is currently highlighted by two features. The first is the extension of the Zwack-Okossi equation, originally formulated for the diagnosis of surface wave development, for application at any pressure level. The second is the separation of the basic large-scale analysis fields into synoptic-scale and planetary-scale components, using a two-dimensional Shapiro filter, and the corresponding partitioning of the Zwack-Okossi equation into synoptic-scale, planetary-scale, and synoptic/planetary-scale interaction terms. Preliminary tests suggest substantial contribution from the synoptic-scale and interaction terms.

  10. Operation of an aquatic worm reactor suitable for sludge reduction at large scale.

    PubMed

    Hendrickx, Tim L G; Elissen, Hellen H J; Temmink, Hardy; Buisman, Cees J N

    2011-10-15

    Treatment of domestic waste water results in the production of waste sludge, which requires costly further processing. A biological method to reduce the amount of waste sludge and its volume is treatment in an aquatic worm reactor. The potential of such a worm reactor with the oligochaete Lumbriculus variegatus has been shown at small scale. For scaling up purposes, a new configuration of the reactor was designed, in which the worms were positioned horizontally in the carrier material. This was tested in a continuous experiment of 8 weeks where it treated all the waste sludge from a lab-scale activated sludge process. The results showed a higher worm growth rate compared to previous experiments with the old configuration, whilst nutrient release was similar. The new configuration has a low footprint and allows for easy aeration and faeces collection, thereby making it suitable for full scale application. Copyright © 2011 Elsevier Ltd. All rights reserved.

  11. Dust Polarization toward Embedded Protostars in Ophiuchus with ALMA. I. VLA 1623

    NASA Astrophysics Data System (ADS)

    Sadavoy, Sarah I.; Myers, Philip C.; Stephens, Ian W.; Tobin, John; Commerçon, Benoît; Henning, Thomas; Looney, Leslie; Kwon, Woojin; Segura-Cox, Dominique; Harris, Robert

    2018-06-01

    We present high-resolution (∼30 au) ALMA Band 6 dust polarization observations of VLA 1623. The VLA 1623 data resolve compact ∼40 au inner disks around the two protobinary sources, VLA 1623-A and VLA 1623-B, and also an extended ∼180 au ring of dust around VLA 1623-A. This dust ring was previously identified as a large disk in lower-resolution observations. We detect highly structured dust polarization toward the inner disks and the extended ring with typical polarization fractions ≈1.7% and ≈2.4%, respectively. The two components also show distinct polarization morphologies. The inner disks have uniform polarization angles aligned with their minor axes. This morphology is consistent with expectations from dust scattering. By contrast, the extended dust ring has an azimuthal polarization morphology not previously seen in lower-resolution observations. We find that our observations are well-fit by a static, oblate spheroid model with a flux-frozen, poloidal magnetic field. We propose that the polarization traces magnetic grain alignment likely from flux freezing on large scales and magnetic diffusion on small scales. Alternatively, the azimuthal polarization may be attributed to grain alignment by the anisotropic radiation field. If the grains are radiatively aligned, then our observations indicate that large (∼100 μm) dust grains grow quickly at large angular extents. Finally, we identify significant proper motion of VLA 1623 using our observations and those in the literature. This result indicates that the proper motion of nearby systems must be corrected for when combining ALMA data from different epochs.

  12. Mechanisms Controlling the Interannual Variation of Mixed Layer Temperature Averaged over the Nino-3 Region

    NASA Technical Reports Server (NTRS)

    Kim, Seung-Bum; Lee, Tong; Fukumori, Ichiro

    2007-01-01

    The present study examines processes governing the interannual variation of MLT in the eastern equatorial Pacific.Processes controlling the interannual variation of mixed layer temperature (MLT) averaged over the Nino-3 domain (5 deg N-5 deg S, 150 deg-90 deg W) are studied using an ocean data assimilation product that covers the period of 1993-2003. The overall balance is such that surface heat flux opposes the MLT change but horizontal advection and subsurface processes assist the change. Advective tendencies are estimated here as the temperature fluxes through the domain's boundaries, with the boundary temperature referenced to the domain-averaged temperature to remove the dependence on temperature scale. This allows the authors to characterize external advective processes that warm or cool the water within the domain as a whole. The zonal advective tendency is caused primarily by large-scale advection of warm-pool water through the western boundary of the domain. The meridional advective tendency is contributed to mostly by Ekman current advecting large-scale temperature anomalies through the southern boundary of the domain. Unlike many previous studies, the subsurface processes that consist of vertical mixing and entrainment are explicitly evaluated. In particular, a rigorous method to estimate entrainment allows an exact budget closure. The vertical mixing across the mixed layer (ML) base has a contribution in phase with the MLT change. The entrainment tendency due to the temporal change in ML depth is negligible compared to other subsurface processes. The entrainment tendency by vertical advection across the ML base is dominated by large-scale changes in upwelling and the temperature of upwelling water. Tropical instability waves (TIWs) result in smaller-scale vertical advection that warms the domain during La Nina cooling events. However, such a warming tendency is overwhelmed by the cooling tendency associated with the large-scale upwelling by a factor of 2. In summary, all the balance terms are important in the MLT budget except the entrainment due to lateral induction and temporal variation in ML depth. All three advective tendencies are primarily caused by large-scale and low-frequency processes, and they assist the Nino-3 MLT change.

  13. Real-time evolution of a large-scale relativistic jet

    NASA Astrophysics Data System (ADS)

    Martí, Josep; Luque-Escamilla, Pedro L.; Romero, Gustavo E.; Sánchez-Sutil, Juan R.; Muñoz-Arjonilla, Álvaro J.

    2015-06-01

    Context. Astrophysical jets are ubiquitous in the Universe on all scales, but their large-scale dynamics and evolution in time are hard to observe since they usually develop at a very slow pace. Aims: We aim to obtain the first observational proof of the expected large-scale evolution and interaction with the environment in an astrophysical jet. Only jets from microquasars offer a chance to witness the real-time, full-jet evolution within a human lifetime, since they combine a "short", few parsec length with relativistic velocities. Methods: The methodology of this work is based on a systematic recalibraton of interferometric radio observations of microquasars available in public archives. In particular, radio observations of the microquasar GRS 1758-258 over less than two decades have provided the most striking results. Results: Significant morphological variations in the extended jet structure of GRS 1758-258 are reported here that were previously missed. Its northern radio lobe underwent a major morphological variation that rendered the hotspot undetectable in 2001 and reappeared again in the following years. The reported changes confirm the Galactic nature of the source. We tentatively interpret them in terms of the growth of instabilities in the jet flow. There is also evidence of surrounding cocoon. These results can provide a testbed for models accounting for the evolution of jets and their interaction with the environment.

  14. Scale-dependent habitat use by a large free-ranging predator, the Mediterranean fin whale

    NASA Astrophysics Data System (ADS)

    Cotté, Cédric; Guinet, Christophe; Taupier-Letage, Isabelle; Mate, Bruce; Petiau, Estelle

    2009-05-01

    Since the heterogeneity of oceanographic conditions drives abundance, distribution, and availability of prey, it is essential to understand how foraging predators interact with their dynamic environment at various spatial and temporal scales. We examined the spatio-temporal relationships between oceanographic features and abundance of fin whales ( Balaenoptera physalus), the largest free-ranging predator in the Western Mediterranean Sea (WM), through two independent approaches. First, spatial modeling was used to estimate whale density, using waiting distance (the distance between detections) for fin whales along ferry routes across the WM, in relation to remotely sensed oceanographic parameters. At a large scale (basin and year), fin whales exhibited fidelity to the northern WM with a summer-aggregated and winter-dispersed pattern. At mesoscale (20-100 km), whales were found in colder, saltier (from an on-board system) and dynamic areas defined by steep altimetric and temperature gradients. Second, using an independent fin whale satellite tracking dataset, we showed that tracked whales were effectively preferentially located in favorable habitats, i.e. in areas of high predicted densities as identified by our previous model using oceanographic data contemporaneous to the tracking period. We suggest that the large-scale fidelity corresponds to temporally and spatially predictable habitat of whale favorite prey, the northern krill ( Meganyctiphanes norvegica), while mesoscale relationships are likely to identify areas of high prey concentration and availability.

  15. Exploring Google Earth Engine platform for big data processing: classification of multi-temporal satellite imagery for crop mapping

    NASA Astrophysics Data System (ADS)

    Shelestov, Andrii; Lavreniuk, Mykola; Kussul, Nataliia; Novikov, Alexei; Skakun, Sergii

    2017-02-01

    Many applied problems arising in agricultural monitoring and food security require reliable crop maps at national or global scale. Large scale crop mapping requires processing and management of large amount of heterogeneous satellite imagery acquired by various sensors that consequently leads to a “Big Data” problem. The main objective of this study is to explore efficiency of using the Google Earth Engine (GEE) platform when classifying multi-temporal satellite imagery with potential to apply the platform for a larger scale (e.g. country level) and multiple sensors (e.g. Landsat-8 and Sentinel-2). In particular, multiple state-of-the-art classifiers available in the GEE platform are compared to produce a high resolution (30 m) crop classification map for a large territory ( 28,100 km2 and 1.0 M ha of cropland). Though this study does not involve large volumes of data, it does address efficiency of the GEE platform to effectively execute complex workflows of satellite data processing required with large scale applications such as crop mapping. The study discusses strengths and weaknesses of classifiers, assesses accuracies that can be achieved with different classifiers for the Ukrainian landscape, and compares them to the benchmark classifier using a neural network approach that was developed in our previous studies. The study is carried out for the Joint Experiment of Crop Assessment and Monitoring (JECAM) test site in Ukraine covering the Kyiv region (North of Ukraine) in 2013. We found that Google Earth Engine (GEE) provides very good performance in terms of enabling access to the remote sensing products through the cloud platform and providing pre-processing; however, in terms of classification accuracy, the neural network based approach outperformed support vector machine (SVM), decision tree and random forest classifiers available in GEE.

  16. Layer-by-layer assembly of two-dimensional materials into wafer-scale heterostructures

    NASA Astrophysics Data System (ADS)

    Kang, Kibum; Lee, Kan-Heng; Han, Yimo; Gao, Hui; Xie, Saien; Muller, David A.; Park, Jiwoong

    2017-10-01

    High-performance semiconductor films with vertical compositions that are designed to atomic-scale precision provide the foundation for modern integrated circuitry and novel materials discovery. One approach to realizing such films is sequential layer-by-layer assembly, whereby atomically thin two-dimensional building blocks are vertically stacked, and held together by van der Waals interactions. With this approach, graphene and transition-metal dichalcogenides--which represent one- and three-atom-thick two-dimensional building blocks, respectively--have been used to realize previously inaccessible heterostructures with interesting physical properties. However, no large-scale assembly method exists at present that maintains the intrinsic properties of these two-dimensional building blocks while producing pristine interlayer interfaces, thus limiting the layer-by-layer assembly method to small-scale proof-of-concept demonstrations. Here we report the generation of wafer-scale semiconductor films with a very high level of spatial uniformity and pristine interfaces. The vertical composition and properties of these films are designed at the atomic scale using layer-by-layer assembly of two-dimensional building blocks under vacuum. We fabricate several large-scale, high-quality heterostructure films and devices, including superlattice films with vertical compositions designed layer-by-layer, batch-fabricated tunnel device arrays with resistances that can be tuned over four orders of magnitude, band-engineered heterostructure tunnel diodes, and millimetre-scale ultrathin membranes and windows. The stacked films are detachable, suspendable and compatible with water or plastic surfaces, which will enable their integration with advanced optical and mechanical systems.

  17. Layer-by-layer assembly of two-dimensional materials into wafer-scale heterostructures.

    PubMed

    Kang, Kibum; Lee, Kan-Heng; Han, Yimo; Gao, Hui; Xie, Saien; Muller, David A; Park, Jiwoong

    2017-10-12

    High-performance semiconductor films with vertical compositions that are designed to atomic-scale precision provide the foundation for modern integrated circuitry and novel materials discovery. One approach to realizing such films is sequential layer-by-layer assembly, whereby atomically thin two-dimensional building blocks are vertically stacked, and held together by van der Waals interactions. With this approach, graphene and transition-metal dichalcogenides-which represent one- and three-atom-thick two-dimensional building blocks, respectively-have been used to realize previously inaccessible heterostructures with interesting physical properties. However, no large-scale assembly method exists at present that maintains the intrinsic properties of these two-dimensional building blocks while producing pristine interlayer interfaces, thus limiting the layer-by-layer assembly method to small-scale proof-of-concept demonstrations. Here we report the generation of wafer-scale semiconductor films with a very high level of spatial uniformity and pristine interfaces. The vertical composition and properties of these films are designed at the atomic scale using layer-by-layer assembly of two-dimensional building blocks under vacuum. We fabricate several large-scale, high-quality heterostructure films and devices, including superlattice films with vertical compositions designed layer-by-layer, batch-fabricated tunnel device arrays with resistances that can be tuned over four orders of magnitude, band-engineered heterostructure tunnel diodes, and millimetre-scale ultrathin membranes and windows. The stacked films are detachable, suspendable and compatible with water or plastic surfaces, which will enable their integration with advanced optical and mechanical systems.

  18. Impact of the nursing home scale on residents' social engagement in South Korea.

    PubMed

    Yoon, Ju Young; Kim, Hongsoo; Jung, Young-Il; Ha, Jung-Hwa

    2016-12-01

    This study aimed to describe the levels of social engagement and to examine the relationship between the nursing home scale groups and social engagement in nursing homes in South Korea. A total of 314 residents were randomly selected from rosters provided by 10 nursing homes located in three metropolitan areas in South Korea. The outcome variable was social engagement measured by the Revised Index of Social Engagement (RISE), and the key independent variable was the nursing home scale (small, medium, and large). Individual factors (age, gender, activities of daily living and cognitive function, and depressive symptoms) and organizational factors (location, ownership, and staffing levels) were controlled in the model as covariates. Multilevel logistic regression was used in this study. About half of the residents (46%) in this study were not socially engaged in the nursing home (RISE=0) where they resided. Controlling for individual- and organizational-level factors, the nursing home facility size was a significant factor to predict the likelihood of residents' social engagement, with that the residents in large-scale nursing homes being less likely to be socially engaged than those in medium-scale nursing homes (odds ratio = 0.457; p-value = 0.005). This study supports evidence from previous studies that smaller-scale nursing homes are likely to provide more person-centered care compared to larger-scale nursing homes. Subsequent quality studies are needed to examine how the mechanisms for how smaller-scale nursing homes can enhance residents' social engagement in terms of care delivery processes.

  19. A quenched study of the Schrödinger functional with chirally rotated boundary conditions: Applications

    NASA Astrophysics Data System (ADS)

    González López, J.; Jansen, K.; Renner, D. B.; Shindler, A.

    2013-02-01

    In a previous paper (González López, et al., 2013) [1], we have discussed the non-perturbative tuning of the chirally rotated Schrödinger functional (χSF). This tuning is required to eliminate bulk O(a) cutoff effects in physical correlation functions. Using our tuning results obtained in González López et al. (2013) [1] we perform scaling and universality tests analyzing the residual O(a) cutoff effects of several step-scaling functions and we compute renormalization factors at the matching scale. As an example of possible application of the χSF we compute the renormalized strange quark mass using large volume data obtained from Wilson twisted mass fermions at maximal twist.

  20. Scale effects between body size and limb design in quadrupedal mammals.

    PubMed

    Kilbourne, Brandon M; Hoffman, Louwrens C

    2013-01-01

    Recently the metabolic cost of swinging the limbs has been found to be much greater than previously thought, raising the possibility that limb rotational inertia influences the energetics of locomotion. Larger mammals have a lower mass-specific cost of transport than smaller mammals. The scaling of the mass-specific cost of transport is partly explained by decreasing stride frequency with increasing body size; however, it is unknown if limb rotational inertia also influences the mass-specific cost of transport. Limb length and inertial properties--limb mass, center of mass (COM) position, moment of inertia, radius of gyration, and natural frequency--were measured in 44 species of terrestrial mammals, spanning eight taxonomic orders. Limb length increases disproportionately with body mass via positive allometry (length ∝ body mass(0.40)); the positive allometry of limb length may help explain the scaling of the metabolic cost of transport. When scaled against body mass, forelimb inertial properties, apart from mass, scale with positive allometry. Fore- and hindlimb mass scale according to geometric similarity (limb mass ∝ body mass(1.0)), as do the remaining hindlimb inertial properties. The positive allometry of limb length is largely the result of absolute differences in limb inertial properties between mammalian subgroups. Though likely detrimental to locomotor costs in large mammals, scale effects in limb inertial properties appear to be concomitant with scale effects in sensorimotor control and locomotor ability in terrestrial mammals. Across mammals, the forelimb's potential for angular acceleration scales according to geometric similarity, whereas the hindlimb's potential for angular acceleration scales with positive allometry.

  1. Scale Effects between Body Size and Limb Design in Quadrupedal Mammals

    PubMed Central

    Kilbourne, Brandon M.; Hoffman, Louwrens C.

    2013-01-01

    Recently the metabolic cost of swinging the limbs has been found to be much greater than previously thought, raising the possibility that limb rotational inertia influences the energetics of locomotion. Larger mammals have a lower mass-specific cost of transport than smaller mammals. The scaling of the mass-specific cost of transport is partly explained by decreasing stride frequency with increasing body size; however, it is unknown if limb rotational inertia also influences the mass-specific cost of transport. Limb length and inertial properties – limb mass, center of mass (COM) position, moment of inertia, radius of gyration, and natural frequency – were measured in 44 species of terrestrial mammals, spanning eight taxonomic orders. Limb length increases disproportionately with body mass via positive allometry (length ∝ body mass0.40); the positive allometry of limb length may help explain the scaling of the metabolic cost of transport. When scaled against body mass, forelimb inertial properties, apart from mass, scale with positive allometry. Fore- and hindlimb mass scale according to geometric similarity (limb mass ∝ body mass1.0), as do the remaining hindlimb inertial properties. The positive allometry of limb length is largely the result of absolute differences in limb inertial properties between mammalian subgroups. Though likely detrimental to locomotor costs in large mammals, scale effects in limb inertial properties appear to be concomitant with scale effects in sensorimotor control and locomotor ability in terrestrial mammals. Across mammals, the forelimb's potential for angular acceleration scales according to geometric similarity, whereas the hindlimb's potential for angular acceleration scales with positive allometry. PMID:24260117

  2. Quantifying aggregated uncertainty in Plasmodium falciparum malaria prevalence and populations at risk via efficient space-time geostatistical joint simulation.

    PubMed

    Gething, Peter W; Patil, Anand P; Hay, Simon I

    2010-04-01

    Risk maps estimating the spatial distribution of infectious diseases are required to guide public health policy from local to global scales. The advent of model-based geostatistics (MBG) has allowed these maps to be generated in a formal statistical framework, providing robust metrics of map uncertainty that enhances their utility for decision-makers. In many settings, decision-makers require spatially aggregated measures over large regions such as the mean prevalence within a country or administrative region, or national populations living under different levels of risk. Existing MBG mapping approaches provide suitable metrics of local uncertainty--the fidelity of predictions at each mapped pixel--but have not been adapted for measuring uncertainty over large areas, due largely to a series of fundamental computational constraints. Here the authors present a new efficient approximating algorithm that can generate for the first time the necessary joint simulation of prevalence values across the very large prediction spaces needed for global scale mapping. This new approach is implemented in conjunction with an established model for P. falciparum allowing robust estimates of mean prevalence at any specified level of spatial aggregation. The model is used to provide estimates of national populations at risk under three policy-relevant prevalence thresholds, along with accompanying model-based measures of uncertainty. By overcoming previously unchallenged computational barriers, this study illustrates how MBG approaches, already at the forefront of infectious disease mapping, can be extended to provide large-scale aggregate measures appropriate for decision-makers.

  3. Using Unplanned Fires to Help Suppressing Future Large Fires in Mediterranean Forests

    PubMed Central

    Regos, Adrián; Aquilué, Núria; Retana, Javier; De Cáceres, Miquel; Brotons, Lluís

    2014-01-01

    Despite the huge resources invested in fire suppression, the impact of wildfires has considerably increased across the Mediterranean region since the second half of the 20th century. Modulating fire suppression efforts in mild weather conditions is an appealing but hotly-debated strategy to use unplanned fires and associated fuel reduction to create opportunities for suppression of large fires in future adverse weather conditions. Using a spatially-explicit fire–succession model developed for Catalonia (Spain), we assessed this opportunistic policy by using two fire suppression strategies that reproduce how firefighters in extreme weather conditions exploit previous fire scars as firefighting opportunities. We designed scenarios by combining different levels of fire suppression efficiency and climatic severity for a 50-year period (2000–2050). An opportunistic fire suppression policy induced large-scale changes in fire regimes and decreased the area burnt under extreme climate conditions, but only accounted for up to 18–22% of the area to be burnt in reference scenarios. The area suppressed in adverse years tended to increase in scenarios with increasing amounts of area burnt during years dominated by mild weather. Climate change had counterintuitive effects on opportunistic fire suppression strategies. Climate warming increased the incidence of large fires under uncontrolled conditions but also indirectly increased opportunities for enhanced fire suppression. Therefore, to shift fire suppression opportunities from adverse to mild years, we would require a disproportionately large amount of area burnt in mild years. We conclude that the strategic planning of fire suppression resources has the potential to become an important cost-effective fuel-reduction strategy at large spatial scale. We do however suggest that this strategy should probably be accompanied by other fuel-reduction treatments applied at broad scales if large-scale changes in fire regimes are to be achieved, especially in the wider context of climate change. PMID:24727853

  4. Using unplanned fires to help suppressing future large fires in Mediterranean forests.

    PubMed

    Regos, Adrián; Aquilué, Núria; Retana, Javier; De Cáceres, Miquel; Brotons, Lluís

    2014-01-01

    Despite the huge resources invested in fire suppression, the impact of wildfires has considerably increased across the Mediterranean region since the second half of the 20th century. Modulating fire suppression efforts in mild weather conditions is an appealing but hotly-debated strategy to use unplanned fires and associated fuel reduction to create opportunities for suppression of large fires in future adverse weather conditions. Using a spatially-explicit fire-succession model developed for Catalonia (Spain), we assessed this opportunistic policy by using two fire suppression strategies that reproduce how firefighters in extreme weather conditions exploit previous fire scars as firefighting opportunities. We designed scenarios by combining different levels of fire suppression efficiency and climatic severity for a 50-year period (2000-2050). An opportunistic fire suppression policy induced large-scale changes in fire regimes and decreased the area burnt under extreme climate conditions, but only accounted for up to 18-22% of the area to be burnt in reference scenarios. The area suppressed in adverse years tended to increase in scenarios with increasing amounts of area burnt during years dominated by mild weather. Climate change had counterintuitive effects on opportunistic fire suppression strategies. Climate warming increased the incidence of large fires under uncontrolled conditions but also indirectly increased opportunities for enhanced fire suppression. Therefore, to shift fire suppression opportunities from adverse to mild years, we would require a disproportionately large amount of area burnt in mild years. We conclude that the strategic planning of fire suppression resources has the potential to become an important cost-effective fuel-reduction strategy at large spatial scale. We do however suggest that this strategy should probably be accompanied by other fuel-reduction treatments applied at broad scales if large-scale changes in fire regimes are to be achieved, especially in the wider context of climate change.

  5. Use of lignocellulosic materials as sorbents for pesticide and phosphate residues

    Treesearch

    Mandla A. Tshabalala

    2006-01-01

    We previously reported results from limited field trials of a bark-based filtration unit designed to remove phosphorus from cranberry bog tail water. In that report we also identified some barriers that needed to be overcome to improve the performance of such a filtration unit. One barrier was lack of a cost effective process for large-scale conversion of bark to an...

  6. Phylogeographic analyses and evaluation of shortleaf pine population structure in Missouri

    Treesearch

    Jeff Koppelman; Emily Parsons; Briedi Scott; Jennifer Collantes; Lori S. Eggert; Sedley Josserand; Craig Echt; C. Dana Nelson

    2007-01-01

    A great expanse of shortleaf pine in Missouri was logged before the mid-20th century, and since that time, seedlings of the species have been planted. Due to large-scale decline in oak trees occupying previous shortleaf pine range, restoration of the shortleaf pine is a priority in Missouri. Restoration can be enhanced through the use of locally adapted trees that have...

  7. A "Politically Robust" Experimental Design for Public Policy Evaluation, with Application to the Mexican Universal Health Insurance Program

    ERIC Educational Resources Information Center

    King, Gary; Gakidou, Emmanuela; Ravishankar, Nirmala; Moore, Ryan T.; Lakin, Jason; Vargas, Manett; Tellez-Rojo, Martha Maria; Avila, Juan Eugenio Hernandez; Avila, Mauricio Hernandez; Llamas, Hector Hernandez

    2007-01-01

    We develop an approach to conducting large-scale randomized public policy experiments intended to be more robust to the political interventions that have ruined some or all parts of many similar previous efforts. Our proposed design is insulated from selection bias in some circumstances even if we lose observations; our inferences can still be…

  8. The Development of Extraversion and Ability: Analysis of Data from a Large-Scale Longitudinal Study of Children Tested at 10-11 and 14-15 Years.

    ERIC Educational Resources Information Center

    Anthony, W. S.

    1983-01-01

    Results of analysis of correlations collected by Cookson, following Eysenck and Cookson's study of personality and ability in young people, confirm the finding from previous Cattellian test data that the more intelligent children decline in relative extraversion scores and cast doubt on Eysenck's suggestion that introverts gradually show higher…

  9. Allometry indicates giant eyes of giant squid are not exceptional.

    PubMed

    Schmitz, Lars; Motani, Ryosuke; Oufiero, Christopher E; Martin, Christopher H; McGee, Matthew D; Gamarra, Ashlee R; Lee, Johanna J; Wainwright, Peter C

    2013-02-18

    The eyes of giant and colossal squid are among the largest eyes in the history of life. It was recently proposed that sperm whale predation is the main driver of eye size evolution in giant squid, on the basis of an optical model that suggested optimal performance in detecting large luminous visual targets such as whales in the deep sea. However, it is poorly understood how the eye size of giant and colossal squid compares to that of other aquatic organisms when scaling effects are considered. We performed a large-scale comparative study that included 87 squid species and 237 species of acanthomorph fish. While squid have larger eyes than most acanthomorphs, a comparison of relative eye size among squid suggests that giant and colossal squid do not have unusually large eyes. After revising constants used in a previous model we found that large eyes perform equally well in detecting point targets and large luminous targets in the deep sea. The eyes of giant and colossal squid do not appear exceptionally large when allometric effects are considered. It is probable that the giant eyes of giant squid result from a phylogenetically conserved developmental pattern manifested in very large animals. Whatever the cause of large eyes, they appear to have several advantages for vision in the reduced light of the deep mesopelagic zone.

  10. Precipitation Dynamical Downscaling Over the Great Plains

    NASA Astrophysics Data System (ADS)

    Hu, Xiao-Ming; Xue, Ming; McPherson, Renee A.; Martin, Elinor; Rosendahl, Derek H.; Qiao, Lei

    2018-02-01

    Detailed, regional climate projections, particularly for precipitation, are critical for many applications. Accurate precipitation downscaling in the United States Great Plains remains a great challenge for most Regional Climate Models, particularly for warm months. Most previous dynamic downscaling simulations significantly underestimate warm-season precipitation in the region. This study aims to achieve a better precipitation downscaling in the Great Plains with the Weather Research and Forecast (WRF) model. To this end, WRF simulations with different physics schemes and nudging strategies are first conducted for a representative warm season. Results show that different cumulus schemes lead to more pronounced difference in simulated precipitation than other tested physics schemes. Simply choosing different physics schemes is not enough to alleviate the dry bias over the southern Great Plains, which is related to an anticyclonic circulation anomaly over the central and western parts of continental U.S. in the simulations. Spectral nudging emerges as an effective solution for alleviating the precipitation bias. Spectral nudging ensures that large and synoptic-scale circulations are faithfully reproduced while still allowing WRF to develop small-scale dynamics, thus effectively suppressing the large-scale circulation anomaly in the downscaling. As a result, a better precipitation downscaling is achieved. With the carefully validated configurations, WRF downscaling is conducted for 1980-2015. The downscaling captures well the spatial distribution of monthly climatology precipitation and the monthly/yearly variability, showing improvement over at least two previously published precipitation downscaling studies. With the improved precipitation downscaling, a better hydrological simulation over the trans-state Oologah watershed is also achieved.

  11. Detecting natural occlusion boundaries using local cues

    PubMed Central

    DiMattina, Christopher; Fox, Sean A.; Lewicki, Michael S.

    2012-01-01

    Occlusion boundaries and junctions provide important cues for inferring three-dimensional scene organization from two-dimensional images. Although several investigators in machine vision have developed algorithms for detecting occlusions and other edges in natural images, relatively few psychophysics or neurophysiology studies have investigated what features are used by the visual system to detect natural occlusions. In this study, we addressed this question using a psychophysical experiment where subjects discriminated image patches containing occlusions from patches containing surfaces. Image patches were drawn from a novel occlusion database containing labeled occlusion boundaries and textured surfaces in a variety of natural scenes. Consistent with related previous work, we found that relatively large image patches were needed to attain reliable performance, suggesting that human subjects integrate complex information over a large spatial region to detect natural occlusions. By defining machine observers using a set of previously studied features measured from natural occlusions and surfaces, we demonstrate that simple features defined at the spatial scale of the image patch are insufficient to account for human performance in the task. To define machine observers using a more biologically plausible multiscale feature set, we trained standard linear and neural network classifiers on the rectified outputs of a Gabor filter bank applied to the image patches. We found that simple linear classifiers could not match human performance, while a neural network classifier combining filter information across location and spatial scale compared well. These results demonstrate the importance of combining a variety of cues defined at multiple spatial scales for detecting natural occlusions. PMID:23255731

  12. BAYESIAN LARGE-SCALE MULTIPLE REGRESSION WITH SUMMARY STATISTICS FROM GENOME-WIDE ASSOCIATION STUDIES1

    PubMed Central

    Zhu, Xiang; Stephens, Matthew

    2017-01-01

    Bayesian methods for large-scale multiple regression provide attractive approaches to the analysis of genome-wide association studies (GWAS). For example, they can estimate heritability of complex traits, allowing for both polygenic and sparse models; and by incorporating external genomic data into the priors, they can increase power and yield new biological insights. However, these methods require access to individual genotypes and phenotypes, which are often not easily available. Here we provide a framework for performing these analyses without individual-level data. Specifically, we introduce a “Regression with Summary Statistics” (RSS) likelihood, which relates the multiple regression coefficients to univariate regression results that are often easily available. The RSS likelihood requires estimates of correlations among covariates (SNPs), which also can be obtained from public databases. We perform Bayesian multiple regression analysis by combining the RSS likelihood with previously proposed prior distributions, sampling posteriors by Markov chain Monte Carlo. In a wide range of simulations RSS performs similarly to analyses using the individual data, both for estimating heritability and detecting associations. We apply RSS to a GWAS of human height that contains 253,288 individuals typed at 1.06 million SNPs, for which analyses of individual-level data are practically impossible. Estimates of heritability (52%) are consistent with, but more precise, than previous results using subsets of these data. We also identify many previously unreported loci that show evidence for association with height in our analyses. Software is available at https://github.com/stephenslab/rss. PMID:29399241

  13. A Practical Computational Method for the Anisotropic Redshift-Space 3-Point Correlation Function

    NASA Astrophysics Data System (ADS)

    Slepian, Zachary; Eisenstein, Daniel J.

    2018-04-01

    We present an algorithm enabling computation of the anisotropic redshift-space galaxy 3-point correlation function (3PCF) scaling as N2, with N the number of galaxies. Our previous work showed how to compute the isotropic 3PCF with this scaling by expanding the radially-binned density field around each galaxy in the survey into spherical harmonics and combining these coefficients to form multipole moments. The N2 scaling occurred because this approach never explicitly required the relative angle between a galaxy pair about the primary galaxy. Here we generalize this work, demonstrating that in the presence of azimuthally-symmetric anisotropy produced by redshift-space distortions (RSD) the 3PCF can be described by two triangle side lengths, two independent total angular momenta, and a spin. This basis for the anisotropic 3PCF allows its computation with negligible additional work over the isotropic 3PCF. We also present the covariance matrix of the anisotropic 3PCF measured in this basis. Our algorithm tracks the full 5-D redshift-space 3PCF, uses an accurate line of sight to each triplet, is exact in angle, and easily handles edge correction. It will enable use of the anisotropic large-scale 3PCF as a probe of RSD in current and upcoming large-scale redshift surveys.

  14. Spatio-temporal trends in crop damage inform recent climate-mediated expansion of a large boreal herbivore into an agro-ecosystem.

    PubMed

    Laforge, Michel P; Michel, Nicole L; Brook, Ryan K

    2017-11-09

    Large-scale climatic fluctuations have caused species range shifts. Moose (Alces alces) have expanded their range southward into agricultural areas previously not considered moose habitat. We found that moose expansion into agro-ecosystems is mediated by broad-scale climatic factors and access to high-quality forage (i.e., crops). We used crop damage records to quantify moose presence across the Canadian Prairies. We regressed latitude of crop damage against North Atlantic Oscillation (NAO) and crop area to test the hypotheses that NAO-mediated wetland recharge and occurrence of more nutritious crop types would result in more frequent occurrences of crop damage by moose at southerly latitudes. We examined local-scale land use by generating a habitat selection model to test our hypothesis that moose selected for areas of high crop cover in agro-ecosystems. We found that crop damage by moose occurred farther south during dry winters and in years with greater coverage of oilseeds. The results of our analyses support our hypothesis that moose movement into cropland is mediated by high-protein crops, but not by thermoregulatory habitat at the scale examined. We conclude that broad-scale climate combined with changing land-use regimes are causal factors in species' range shifts and are important considerations when studying changing animal distributions.

  15. Economic Impact of Large-Scale Deployment of Offshore Marine and Hydrokinetic Technology in Oregon Coastal Counties

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jimenez, T.; Tegen, S.; Beiter, P.

    To begin understanding the potential economic impacts of large-scale WEC technology, the Bureau of Ocean Energy Management (BOEM) commissioned the National Renewable Energy Laboratory (NREL) to conduct an economic impact analysis of largescale WEC deployment for Oregon coastal counties. This report follows a previously published report by BOEM and NREL on the jobs and economic impacts of WEC technology for the entire state (Jimenez and Tegen 2015). As in Jimenez and Tegen (2015), this analysis examined two deployment scenarios in the 2026-2045 timeframe: the first scenario assumed 13,000 megawatts (MW) of WEC technology deployed during the analysis period, and themore » second assumed 18,000 MW of WEC technology deployed by 2045. Both scenarios require major technology and cost improvements in the WEC devices. The study is on very large-scale deployment so readers can examine and discuss the potential of a successful and very large WEC industry. The 13,000-MW is used as the basis for the county analysis as it is the smaller of the two scenarios. Sensitivity studies examined the effects of a robust in-state WEC supply chain. The region of analysis is comprised of the seven coastal counties in Oregon—Clatsop, Coos, Curry, Douglas, Lane, Lincoln, and Tillamook—so estimates of jobs and other economic impacts are specific to this coastal county area.« less

  16. Large density expansion of a hydrodynamic theory for self-propelled particles

    NASA Astrophysics Data System (ADS)

    Ihle, T.

    2015-07-01

    Recently, an Enskog-type kinetic theory for Vicsek-type models for self-propelled particles has been proposed [T. Ihle, Phys. Rev. E 83, 030901 (2011)]. This theory is based on an exact equation for a Markov chain in phase space and is not limited to small density. Previously, the hydrodynamic equations were derived from this theory and its transport coefficients were given in terms of infinite series. Here, I show that the transport coefficients take a simple form in the large density limit. This allows me to analytically evaluate the well-known density instability of the polarly ordered phase near the flocking threshold at moderate and large densities. The growth rate of a longitudinal perturbation is calculated and several scaling regimes, including three different power laws, are identified. It is shown that at large densities, the restabilization of the ordered phase at smaller noise is analytically accessible within the range of validity of the hydrodynamic theory. Analytical predictions for the width of the unstable band, the maximum growth rate, and for the wave number below which the instability occurs are given. In particular, the system size below which spatial perturbations of the homogeneous ordered state are stable is predicted to scale with where √ M is the average number of collision partners. The typical time scale until the instability becomes visible is calculated and is proportional to M.

  17. Improved regional-scale Brazilian cropping systems' mapping based on a semi-automatic object-based clustering approach

    NASA Astrophysics Data System (ADS)

    Bellón, Beatriz; Bégué, Agnès; Lo Seen, Danny; Lebourgeois, Valentine; Evangelista, Balbino Antônio; Simões, Margareth; Demonte Ferraz, Rodrigo Peçanha

    2018-06-01

    Cropping systems' maps at fine scale over large areas provide key information for further agricultural production and environmental impact assessments, and thus represent a valuable tool for effective land-use planning. There is, therefore, a growing interest in mapping cropping systems in an operational manner over large areas, and remote sensing approaches based on vegetation index time series analysis have proven to be an efficient tool. However, supervised pixel-based approaches are commonly adopted, requiring resource consuming field campaigns to gather training data. In this paper, we present a new object-based unsupervised classification approach tested on an annual MODIS 16-day composite Normalized Difference Vegetation Index time series and a Landsat 8 mosaic of the State of Tocantins, Brazil, for the 2014-2015 growing season. Two variants of the approach are compared: an hyperclustering approach, and a landscape-clustering approach involving a previous stratification of the study area into landscape units on which the clustering is then performed. The main cropping systems of Tocantins, characterized by the crop types and cropping patterns, were efficiently mapped with the landscape-clustering approach. Results show that stratification prior to clustering significantly improves the classification accuracies for underrepresented and sparsely distributed cropping systems. This study illustrates the potential of unsupervised classification for large area cropping systems' mapping and contributes to the development of generic tools for supporting large-scale agricultural monitoring across regions.

  18. Aetiology for the covariation between combined type ADHD and reading difficulties in a family study: the role of IQ

    PubMed Central

    Cheung, Celeste H.M.; Wood, Alexis C.; Paloyelis, Yannis; Arias-Vasquez, Alejandro; Buitelaar, Jan K.; Franke, Barbara; Miranda, Ana; Mulas, Fernando; Rommelse, Nanda; Sergeant, Joseph A.; Sonuga-Barke, Edmund J.; Faraone, Stephen V.; Asherson, Philip; Kuntsi, Jonna

    2012-01-01

    Background Twin studies using both clinical and population-based samples suggest that the frequent co-occurrence of attention deficit hyperactivity disorder (ADHD) and reading ability/disability (RD) is largely driven by shared genetic influences. While both disorders are associated with lower IQ, recent twin data suggest that the shared genetic variability between reading difficulties and ADHD inattention symptoms is largely independent from genetic influences contributing to general cognitive ability. The current study aimed to extend the previous findings that were based on rating scale measures in a population sample by examining the generalizability of the findings to a clinical population, and by measuring reading difficulties both with a rating scale and with an objective task. We therefore investigated the familial relationships between ADHD, reading difficulties and IQ in a sample of individuals diagnosed with ADHD combined type, their siblings and control sibling pairs. Methods We ran multivariate familial models on data from 1789 individuals at ages 6 to 19. Reading difficulties were measured with both rating scale and an objective task. IQ was obtained using the Wechsler Intelligence Scales (WISC-III / WAIS-III). Results Significant phenotypic (0.2–0.4) and familial (0.3–0.5) correlations were observed among ADHD, reading difficulties and IQ. Yet 53% to 72% of the overlapping familial influences between ADHD and reading difficulties were not shared with IQ. Conclusions Our finding that familial influences shared with general cognitive ability, though present, do not account for the majority of the overlapping familial influences on ADHD and reading difficulties extends previous findings from a population-based study to a clinically-ascertained sample with combined type ADHD. PMID:22324316

  19. Clinical features of pure obsessive-compulsive disorder.

    PubMed

    Torres, Albina R; Shavitt, Roseli G; Torresan, Ricardo C; Ferrão, Ygor A; Miguel, Euripedes C; Fontenelle, Leonardo F

    2013-10-01

    Psychiatric comorbidity is the rule in obsessive-compulsive disorder (OCD); however, very few studies have evaluated the clinical characteristics of patients with no co-occurring disorders (non-comorbid or "pure" OCD). The aim of this study was to estimate the prevalence of pure cases in a large multicenter sample of OCD patients and compare the sociodemographic and clinical characteristics of individuals with and without any lifetime axis I comorbidity. A cross-sectional study with 955 adult patients of the Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders (C-TOC). Assessment instruments included the Yale-Brown Obsessive-Compulsive Scale, the Dimensional Yale-Brown Obsessive-Compulsive Scale, The USP-Sensory Phenomena Scale and the Brown Assessment of Beliefs Scale. Comorbidities were evaluated using the Structured Clinical Interview for DSM-IV Axis I Disorders. Bivariate analyses were followed by logistic regression. Only 74 patients (7.7%) presented pure OCD. Compared with those presenting at least one lifetime comorbidity (881, 92.3%), non-comorbid patients were more likely to be female and to be working, reported less traumatic experiences and presented lower scores in the Y-BOCS obsession subscale and in total DY-BOCS scores. All symptom dimensions except contamination-cleaning and hoarding were less severe in non-comorbid patients. They also presented less severe depression and anxiety, lower suicidality and less previous treatments. In the logistic regression, the following variables predicted pure OCD: sex, severity of depressive and anxious symptoms, previous suicidal thoughts and psychotherapy. Pure OCD patients were the minority in this large sample and were characterized by female sex, less severe depressive and anxious symptoms, less suicidal thoughts and less use of psychotherapy as a treatment modality. The implications of these findings for clinical practice are discussed. Copyright © 2013 Elsevier Inc. All rights reserved.

  20. Highly turbulent solutions of the Lagrangian-averaged Navier-Stokes alpha model and their large-eddy-simulation potential.

    PubMed

    Pietarila Graham, Jonathan; Holm, Darryl D; Mininni, Pablo D; Pouquet, Annick

    2007-11-01

    We compute solutions of the Lagrangian-averaged Navier-Stokes alpha - (LANS alpha ) model for significantly higher Reynolds numbers (up to Re approximately 8300 ) than have previously been accomplished. This allows sufficient separation of scales to observe a Navier-Stokes inertial range followed by a second inertial range specific to the LANS alpha model. Both fully helical and nonhelical flows are examined, up to Reynolds numbers of approximately 1300. Analysis of the third-order structure function scaling supports the predicted l3 scaling; it corresponds to a k-1 scaling of the energy spectrum for scales smaller than alpha. The energy spectrum itself shows a different scaling, which goes as k1. This latter spectrum is consistent with the absence of stretching in the subfilter scales due to the Taylor frozen-in hypothesis employed as a closure in the derivation of the LANS alpha model. These two scalings are conjectured to coexist in different spatial portions of the flow. The l3 [E(k) approximately k-1] scaling is subdominant to k1 in the energy spectrum, but the l3 scaling is responsible for the direct energy cascade, as no cascade can result from motions with no internal degrees of freedom. We demonstrate verification of the prediction for the size of the LANS alpha attractor resulting from this scaling. From this, we give a methodology either for arriving at grid-independent solutions for the LANS alpha model, or for obtaining a formulation of the large eddy simulation optimal in the context of the alpha models. The fully converged grid-independent LANS alpha model may not be the best approximation to a direct numerical simulation of the Navier-Stokes equations, since the minimum error is a balance between truncation errors and the approximation error due to using the LANS alpha instead of the primitive equations. Furthermore, the small-scale behavior of the LANS alpha model contributes to a reduction of flux at constant energy, leading to a shallower energy spectrum for large alpha. These small-scale features, however, do not preclude the LANS alpha model from reproducing correctly the intermittency properties of the high-Reynolds-number flow.

  1. Mouse Activity across Time Scales: Fractal Scenarios

    PubMed Central

    Lima, G. Z. dos Santos; Lobão-Soares, B.; do Nascimento, G. C.; França, Arthur S. C.; Muratori, L.; Ribeiro, S.; Corso, G.

    2014-01-01

    In this work we devise a classification of mouse activity patterns based on accelerometer data using Detrended Fluctuation Analysis. We use two characteristic mouse behavioural states as benchmarks in this study: waking in free activity and slow-wave sleep (SWS). In both situations we find roughly the same pattern: for short time intervals we observe high correlation in activity - a typical 1/f complex pattern - while for large time intervals there is anti-correlation. High correlation of short intervals ( to : waking state and to : SWS) is related to highly coordinated muscle activity. In the waking state we associate high correlation both to muscle activity and to mouse stereotyped movements (grooming, waking, etc.). On the other side, the observed anti-correlation over large time scales ( to : waking state and to : SWS) during SWS appears related to a feedback autonomic response. The transition from correlated regime at short scales to an anti-correlated regime at large scales during SWS is given by the respiratory cycle interval, while during the waking state this transition occurs at the time scale corresponding to the duration of the stereotyped mouse movements. Furthermore, we find that the waking state is characterized by longer time scales than SWS and by a softer transition from correlation to anti-correlation. Moreover, this soft transition in the waking state encompass a behavioural time scale window that gives rise to a multifractal pattern. We believe that the observed multifractality in mouse activity is formed by the integration of several stereotyped movements each one with a characteristic time correlation. Finally, we compare scaling properties of body acceleration fluctuation time series during sleep and wake periods for healthy mice. Interestingly, differences between sleep and wake in the scaling exponents are comparable to previous works regarding human heartbeat. Complementarily, the nature of these sleep-wake dynamics could lead to a better understanding of neuroautonomic regulation mechanisms. PMID:25275515

  2. Charged-Particle Transport in the Data-Driven, Non-Isotropic Turbulent Mangetic Field in the Solar Wind

    NASA Astrophysics Data System (ADS)

    Sun, P.; Jokipii, J. R.; Giacalone, J.

    2016-12-01

    Anisotropies in astrophysical turbulence has been proposed and observed for a long time. And recent observations adopting the multi-scale analysis techniques provided a detailed description of the scale-dependent power spectrum of the magnetic field parallel and perpendicular to the scale-dependent magnetic field line at different scales in the solar wind. In the previous work, we proposed a multi-scale method to synthesize non-isotropic turbulent magnetic field with pre-determined power spectra of the fluctuating magnetic field as a function of scales. We present the effect of test particle transport in the resulting field with a two-scale algorithm. We find that the scale-dependent turbulence anisotropy has a significant difference in the effect on charged par- ticle transport from what the isotropy or the global anisotropy has. It is important to apply this field synthesis method to the solar wind magnetic field based on spacecraft data. However, this relies on how we extract the power spectra of the turbulent magnetic field across different scales. In this study, we propose here a power spectrum synthesis method based on Fourier analysis to extract the large and small scale power spectrum from a single spacecraft observation with a long enough period and a high sampling frequency. We apply the method to the solar wind measurement by the magnetometer onboard the ACE spacecraft and regenerate the large scale isotropic 2D spectrum and the small scale anisotropic 2D spectrum. We run test particle simulations in the magnetid field generated in this way to estimate the transport coefficients and to compare with the isotropic turbulence model.

  3. Large scale food retailing as an intervention for diet and health: quasi-experimental evaluation of a natural experiment.

    PubMed

    Cummins, Steven; Petticrew, Mark; Higgins, Cassie; Findlay, Anne; Sparks, Leigh

    2005-12-01

    To assess the effect on fruit and vegetable consumption, self reported, and psychological health of a "natural experiment"-the introduction of large scale food retailing in a deprived Scottish community. Prospective quasi-experimental design comparing baseline and follow up data in an "intervention" community with a matched "comparison" community in Glasgow, UK. 412 men and women aged 16 or over for whom follow up data on fruit and vegetable consumption and GHQ-12 were available. Fruit and vegetable consumption in portions per day, poor self reported health, and poor psychological health (GHQ-12). Adjusting for age, sex, educational attainment, and employment status there was no population impact on daily fruit and vegetable consumption, self reported, and psychological health. There was some evidence for a net reduction in the prevalence of poor psychological health for residents who directly engaged with the intervention. Government policy has advocated using large scale food retailing as a social intervention to improve diet and health in poor communities. In contrast with a previous uncontrolled study this study did not find evidence for a net intervention effect on fruit and vegetable consumption, although there was evidence for an improvement in psychological health for those who directly engaged with the intervention. Although definitive conclusions about the effect of large scale retailing on diet and health in deprived communities cannot be drawn from non-randomised controlled study designs, evaluations of the impacts of natural experiments may offer the best opportunity to generate evidence about the health impacts of retail interventions in poor communities.

  4. Large-Scale Flow Structure in Turbulent Nonpremixed Flames under Normal- And Low-Gravity Conditions

    NASA Technical Reports Server (NTRS)

    Clemens, N. T.; Idicheria, C. A.; Boxx, I. G.

    2001-01-01

    It is well known that buoyancy has a major influence on the flow structure of turbulent nonpremixed jet flames. Buoyancy acts by inducing baroclinic torques, which generate large-scale vortical structures that can significantly modify the flow field. Furthermore, some suggest that buoyancy can substantially influence the large-scale structure of even nominally momentum-dominated flames, since the low velocity flow outside of the flame will be more susceptible to buoyancy effects. Even subtle buoyancy effects may be important because changes in the large-scale structure affects the local entrainment and fluctuating strain rate, and hence the structure of the flame. Previous studies that have compared the structure of normal- and micro-gravity nonpremixed jet flames note that flames in microgravity are longer and wider than in normal-gravity. This trend was observed for jet flames ranging from laminar to turbulent regimes. Furthermore, imaging of the flames has shown possible evidence of helical instabilities and disturbances starting from the base of the flame in microgravity. In contrast, these characteristics were not observed in normal-gravity. The objective of the present study is to further advance our knowledge of the effects of weak levels of buoyancy on the structure of transitional and turbulent nonpremixed jet flames. In later studies we will utilize the drop tower facilities at NASA Glenn Research Center (GRC), but the preliminary work described in this paper was conducted using the 1.25-second drop tower located at the University of Texas at Austin. A more detailed description of these experiments can be found in Idicheria et al.

  5. Understanding Atmospheric Anomalies Associated with Seasonal Pluvial-Drought Processes Using Southwest China as an Example

    NASA Astrophysics Data System (ADS)

    Liu, Z.; LU, G.; He, H.; Wu, Z.; He, J.

    2017-12-01

    Seasonal pluvial-drought transition processes are unique natural phenomena. To explore possible mechanisms, we considered Southwest China (SWC) as the study region and comprehensively investigated the temporal evolution of large-scale and regional atmospheric variables with the simple method of Standardized Anomalies (SA). Some key results include: (1) The net vertical integral of water vapour flux (VIWVF) across the four boundaries may be a feasible indicator of pluvial-drought transition processes over SWC, because its SA-based index is almost consistent with process development. (2) The vertical SA-based patterns of regional horizontal divergence (D) and vertical motion (ω) also coincides with the pluvial-drought transition processes well, and the SA-based index of regional D show relatively high correlation with the identified processes over SWC. (3) With respect to large-scale anomalies of circulation patterns, a well-organized Eurasian Pattern is one important feature during the pluvial-drought transition over SWC. (4) To explore the possibility of simulating drought development using previous pluvial anomalies, large-scale and regional atmospheric SA-based indices were used. As a whole, when SA-based indices of regional dynamic and water-vapor variables are introduced, simulated drought development only with large-scale anomalies can be improved a lot. (5) Eventually, pluvial-drought transition processes and associated regional atmospheric anomalies over nine Chinese drought study regions were investigated. With respect to regional D, vertically single or double "upper-positive-lower-negative" and "upper-negative-lower-positive" patterns are the most common vertical SA-based patterns during the pluvial and drought parts of transition processes, respectively.

  6. Varying Herbivore Population Structure Correlates with Lack of Local Adaptation in a Geographic Variable Plant-Herbivore Interaction

    PubMed Central

    Cogni, Rodrigo; Trigo, José R.; Futuyma, Douglas J.

    2011-01-01

    Local adaptation of parasites to their hosts due to coevolution is a central prediction of many theories in evolutionary biology. However, empirical studies looking for parasite local adaptation show great variation in outcomes, and the reasons for such variation are largely unknown. In a previous study, we showed adaptive differentiation in the arctiid moth Utetheisa ornatrix to its host plant, the pyrrolizidine alkaloid-bearing legume Crotalaria pallida, at the continental scale, but found no differentiation at the regional scale. In the present study, we sampled the same sites to investigate factors that may contribute to the lack of differentiation at the regional scale. We performed field observations that show that specialist and non-specialist polyphagous herbivore incidence varies among populations at both scales. With a series of common-garden experiments we show that some plant traits that may affect herbivory (pyrrolizidine alkaloids and extrafloral nectaries) vary at the regional scale, while other traits (trichomes and nitrogen content) just vary at the continental scale. These results, combined with our previous evidence for plant population differentiation based on larval performance on fresh fruits, suggest that U. ornatrix is subjected to divergent selection even at the regional scale. Finally, with a microsatellite study we investigated population structure of U. ornatrix. We found that population structure is not stable over time: we found population differentiation at the regional scale in the first year of sampling, but not in the second year. Unstable population structure of the herbivore is the most likely cause of the lack of regional adaptation. PMID:22220208

  7. Micron-scale mapping of megagauss magnetic fields using optical polarimetry to probe hot electron transport in petawatt-class laser-solid interactions.

    PubMed

    Chatterjee, Gourab; Singh, Prashant Kumar; Robinson, A P L; Blackman, D; Booth, N; Culfa, O; Dance, R J; Gizzi, L A; Gray, R J; Green, J S; Koester, P; Kumar, G Ravindra; Labate, L; Lad, Amit D; Lancaster, K L; Pasley, J; Woolsey, N C; Rajeev, P P

    2017-08-21

    The transport of hot, relativistic electrons produced by the interaction of an intense petawatt laser pulse with a solid has garnered interest due to its potential application in the development of innovative x-ray sources and ion-acceleration schemes. We report on spatially and temporally resolved measurements of megagauss magnetic fields at the rear of a 50-μm thick plastic target, irradiated by a multi-picosecond petawatt laser pulse at an incident intensity of ~10 20 W/cm 2 . The pump-probe polarimetric measurements with micron-scale spatial resolution reveal the dynamics of the magnetic fields generated by the hot electron distribution at the target rear. An annular magnetic field profile was observed ~5 ps after the interaction, indicating a relatively smooth hot electron distribution at the rear-side of the plastic target. This is contrary to previous time-integrated measurements, which infer that such targets will produce highly structured hot electron transport. We measured large-scale filamentation of the hot electron distribution at the target rear only at later time-scales of ~10 ps, resulting in a commensurate large-scale filamentation of the magnetic field profile. Three-dimensional hybrid simulations corroborate our experimental observations and demonstrate a beam-like hot electron transport at initial time-scales that may be attributed to the local resistivity profile at the target rear.

  8. Modelling solute dispersion in periodic heterogeneous porous media: Model benchmarking against intermediate scale experiments

    NASA Astrophysics Data System (ADS)

    Majdalani, Samer; Guinot, Vincent; Delenne, Carole; Gebran, Hicham

    2018-06-01

    This paper is devoted to theoretical and experimental investigations of solute dispersion in heterogeneous porous media. Dispersion in heterogenous porous media has been reported to be scale-dependent, a likely indication that the proposed dispersion models are incompletely formulated. A high quality experimental data set of breakthrough curves in periodic model heterogeneous porous media is presented. In contrast with most previously published experiments, the present experiments involve numerous replicates. This allows the statistical variability of experimental data to be accounted for. Several models are benchmarked against the data set: the Fickian-based advection-dispersion, mobile-immobile, multirate, multiple region advection dispersion models, and a newly proposed transport model based on pure advection. A salient property of the latter model is that its solutions exhibit a ballistic behaviour for small times, while tending to the Fickian behaviour for large time scales. Model performance is assessed using a novel objective function accounting for the statistical variability of the experimental data set, while putting equal emphasis on both small and large time scale behaviours. Besides being as accurate as the other models, the new purely advective model has the advantages that (i) it does not exhibit the undesirable effects associated with the usual Fickian operator (namely the infinite solute front propagation speed), and (ii) it allows dispersive transport to be simulated on every heterogeneity scale using scale-independent parameters.

  9. Inflationary magnetogenesis without the strong coupling problem

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ferreira, Ricardo J.Z.; Jain, Rajeev Kumar; Sloth, Martin S., E-mail: ferreira@cp3.dias.sdu.dk, E-mail: jain@cp3.dias.sdu.dk, E-mail: sloth@cp3.dias.sdu.dk

    2013-10-01

    The simplest gauge invariant models of inflationary magnetogenesis are known to suffer from the problems of either large backreaction or strong coupling, which make it difficult to self-consistently achieve cosmic magnetic fields from inflation with a field strength larger than 10{sup −32}G today on the Mpc scale. Such a strength is insufficient to act as seed for the galactic dynamo effect, which requires a magnetic field larger than 10{sup −20}G. In this paper we analyze simple extensions of the minimal model, which avoid both the strong coupling and back reaction problems, in order to generate sufficiently large magnetic fields onmore » the Mpc scale today. First we study the possibility that the coupling function which breaks the conformal invariance of electromagnetism is non-monotonic with sharp features. Subsequently, we consider the effect of lowering the energy scale of inflation jointly with a scenario of prolonged reheating where the universe is dominated by a stiff fluid for a short period after inflation. In the latter case, a systematic study shows upper bounds for the magnetic field strength today on the Mpc scale of 10{sup −13}G for low scale inflation and 10{sup −25}G for high scale inflation, thus improving on the previous result by 7-19 orders of magnitude. These results are consistent with the strong coupling and backreaction constraints.« less

  10. Optical metasurfaces for high angle steering at visible wavelengths

    DOE PAGES

    Lin, Dianmin; Melli, Mauro; Poliakov, Evgeni; ...

    2017-05-23

    Metasurfaces have facilitated the replacement of conventional optical elements with ultrathin and planar photonic structures. Previous designs of metasurfaces were limited to small deflection angles and small ranges of the angle of incidence. Here, we have created two types of Si-based metasurfaces to steer visible light to a large deflection angle. These structures exhibit high diffraction efficiencies over a broad range of angles of incidence. We have demonstrated metasurfaces working both in transmission and reflection modes based on conventional thin film silicon processes that are suitable for the large-scale fabrication of high-performance devices.

  11. Group music performance causes elevated pain thresholds and social bonding in small and large groups of singers

    PubMed Central

    Weinstein, Daniel; Launay, Jacques; Pearce, Eiluned; Dunbar, Robin I. M.; Stewart, Lauren

    2016-01-01

    Over our evolutionary history, humans have faced the problem of how to create and maintain social bonds in progressively larger groups compared to those of our primate ancestors. Evidence from historical and anthropological records suggests that group music-making might act as a mechanism by which this large-scale social bonding could occur. While previous research has shown effects of music making on social bonds in small group contexts, the question of whether this effect ‘scales up’ to larger groups is particularly important when considering the potential role of music for large-scale social bonding. The current study recruited individuals from a community choir that met in both small (n = 20 – 80) and large (a ‘megachoir’ combining individuals from the smaller subchoirs n = 232) group contexts. Participants gave self-report measures (via a survey) of social bonding and had pain threshold measurements taken (as a proxy for endorphin release) before and after 90 minutes of singing. Results showed that feelings of inclusion, connectivity, positive affect, and measures of endorphin release all increased across singing rehearsals and that the influence of group singing was comparable for pain thresholds in the large versus small group context. Levels of social closeness were found to be greater at pre- and post-levels for the small choir condition. However, the large choir condition experienced a greater change in social closeness as compared to the small condition. The finding that singing together fosters social closeness – even in large contexts where individuals are not known to each other – is consistent with evolutionary accounts that emphasize the role of music in social bonding, particularly in the context of creating larger cohesive groups than other primates are able to manage. PMID:27158219

  12. Energy Spectra of Higher Reynolds Number Turbulence by the DNS with up to 122883 Grid Points

    NASA Astrophysics Data System (ADS)

    Ishihara, Takashi; Kaneda, Yukio; Morishita, Koji; Yokokawa, Mitsuo; Uno, Atsuya

    2014-11-01

    Large-scale direct numerical simulations (DNS) of forced incompressible turbulence in a periodic box with up to 122883 grid points have been performed using K computer. The maximum Taylor-microscale Reynolds number Rλ, and the maximum Reynolds number Re based on the integral length scale are over 2000 and 105, respectively. Our previous DNS with Rλ up to 1100 showed that the energy spectrum has a slope steeper than - 5 / 3 (the Kolmogorov scaling law) by factor 0 . 1 at the wavenumber range (kη < 0 . 03). Here η is the Kolmogorov length scale. Our present DNS at higher resolutions show that the energy spectra with different Reynolds numbers (Rλ > 1000) are well normalized not by the integral length-scale but by the Kolmogorov length scale, at the wavenumber range of the steeper slope. This result indicates that the steeper slope is not inherent character in the inertial subrange, and is affected by viscosity.

  13. RESOLVING THE ROTATION MEASURE OF THE M87 JET ON KILOPARSEC SCALES

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Algaba, J. C.; Asada, K.; Nakamura, M., E-mail: algaba@asiaa.sinica.edu.tw

    2016-06-01

    We investigate the distribution of Faraday rotation measure (RM) in the M87 jet at arcsecond scales by using archival polarimetric Very Large Array data at 8, 15, 22 and 43 GHz. We resolve the structure of the RM in several knots along the jet for the first time. We derive the power spectrum in the arcsecond-scale jet and find indications that the RM cannot be associated with a turbulent magnetic field with a 3D Kolmogorov spectrum. Our analysis indicates that the RM probed on jet scales has a significant contribution of a Faraday screen associated with the vicinity of themore » jet, in contrast with that on kiloparsec scales, typically assumed to be disconnected from the jet. Comparison with previous RM analyses suggests that the magnetic fields giving rise to the RMs observed in jet scales have different properties and are well less turbulent than those observed in the lobes.« less

  14. Built-In Data-Flow Integration Testing in Large-Scale Component-Based Systems

    NASA Astrophysics Data System (ADS)

    Piel, Éric; Gonzalez-Sanchez, Alberto; Gross, Hans-Gerhard

    Modern large-scale component-based applications and service ecosystems are built following a number of different component models and architectural styles, such as the data-flow architectural style. In this style, each building block receives data from a previous one in the flow and sends output data to other components. This organisation expresses information flows adequately, and also favours decoupling between the components, leading to easier maintenance and quicker evolution of the system. Integration testing is a major means to ensure the quality of large systems. Their size and complexity, together with the fact that they are developed and maintained by several stake holders, make Built-In Testing (BIT) an attractive approach to manage their integration testing. However, so far no technique has been proposed that combines BIT and data-flow integration testing. We have introduced the notion of a virtual component in order to realize such a combination. It permits to define the behaviour of several components assembled to process a flow of data, using BIT. Test-cases are defined in a way that they are simple to write and flexible to adapt. We present two implementations of our proposed virtual component integration testing technique, and we extend our previous proposal to detect and handle errors in the definition by the user. The evaluation of the virtual component testing approach suggests that more issues can be detected in systems with data-flows than through other integration testing approaches.

  15. Probing Seismically Melting Induced Mantle Heterogeneities in Thermal-chemical Convection Models

    NASA Astrophysics Data System (ADS)

    Heck, H. V.; Davies, H.; Nowacki, A.; Wookey, J. M.

    2015-12-01

    Two regions at the base of the Earth's mantle (the Large Low-Shear Velocity Provinces) pose a fundamental problem in understanding large-scale mantle dynamics and history. Are they dense piles of (possibly primordial) material separated from mantle circulation, or large-scale thermal features which are part of global mantle convection? Or some combination of the two? We use our numerical 3D spherical mantle convection code to perform simulations of the Earths mantle dynamical evolution. We drive the surface velocity of the model according to 200 Ma plate motion reconstructions, to arrive at Earth-like structures in the mantle at present day. Variations in bulk chemistry will be tracked in two ways: 1) by starting the calculations with a (primordial) dense layer at the base of the mantle, and 2) by tracking basalt fraction which is fractionated upon melting close to the surface. The resulting distribution of chemical heterogeneity and temperature will be converted to seismic velocities. This will be done with a thermodynamical database (Stixrude & Lithgow-Bertelloni, GJI, 2005, 2011), allowing us to compare the model with previous observations of triplications and waveform complexity near the margins of the LLSVPs. These observations have been taken as proof that strong chemical variations are present; our simulations can be used to show whether this is true, or if purely thermal convection can also cause these features. We simulate finite-frequency, 3D seismograms at ~5 s period and compare these with previous studies.

  16. Downscaling Ocean Conditions: Initial Results using a Quasigeostrophic and Realistic Ocean Model

    NASA Astrophysics Data System (ADS)

    Katavouta, Anna; Thompson, Keith

    2014-05-01

    Previous theoretical work (Henshaw et al, 2003) has shown that the small-scale modes of variability of solutions of the unforced, incompressible Navier-Stokes equation, and Burgers' equation, can be reconstructed with surprisingly high accuracy from the time history of a few of the large-scale modes. Motivated by this theoretical work we first describe a straightforward method for assimilating information on the large scales in order to recover the small scale oceanic variability. The method is based on nudging in specific wavebands and frequencies and is similar to the so-called spectral nudging method that has been used successfully for atmospheric downscaling with limited area models (e.g. von Storch et al., 2000). The validity of the method is tested using a quasigestrophic model configured to simulate a double ocean gyre separated by an unstable mid-ocean jet. It is shown that important features of the ocean circulation including the position of the meandering mid-ocean jet and associated pinch-off eddies can indeed be recovered from the time history of a small number of large-scales modes. The benefit of assimilating additional time series of observations from a limited number of locations, that alone are too sparse to significantly improve the recovery of the small scales using traditional assimilation techniques, is also demonstrated using several twin experiments. The final part of the study outlines the application of the approach using a realistic high resolution (1/36 degree) model, based on the NEMO (Nucleus for European Modelling of the Ocean) modeling framework, configured for the Scotian Shelf of the east coast of Canada. The large scale conditions used in this application are obtained from the HYCOM (HYbrid Coordinate Ocean Model) + NCODA (Navy Coupled Ocean Data Assimilation) global 1/12 degree analysis product. Henshaw, W., Kreiss, H.-O., Ystrom, J., 2003. Numerical experiments on the interaction between the larger- and the small-scale motion of the Navier-Stokes equations. Multiscale Modeling and Simulation 1, 119-149. von Storch, H., Langenberg, H., Feser, F., 2000. A spectral nudging technique for dynamical downscaling purposes. Monthly Weather Review 128, 3664-3673.

  17. Impact of SCALE-UP on science teaching self-efficacy of students in general education science courses

    NASA Astrophysics Data System (ADS)

    Cassani, Mary Kay Kuhr

    The objective of this study was to evaluate the effect of two pedagogical models used in general education science on non-majors' science teaching self-efficacy. Science teaching self-efficacy can be influenced by inquiry and cooperative learning, through cognitive mechanisms described by Bandura (1997). The Student Centered Activities for Large Enrollment Undergraduate Programs (SCALE-UP) model of inquiry and cooperative learning incorporates cooperative learning and inquiry-guided learning in large enrollment combined lecture-laboratory classes (Oliver-Hoyo & Beichner, 2004). SCALE-UP was adopted by a small but rapidly growing public university in the southeastern United States in three undergraduate, general education science courses for non-science majors in the Fall 2006 and Spring 2007 semesters. Students in these courses were compared with students in three other general education science courses for non-science majors taught with the standard teaching model at the host university. The standard model combines lecture and laboratory in the same course, with smaller enrollments and utilizes cooperative learning. Science teaching self-efficacy was measured using the Science Teaching Efficacy Belief Instrument - B (STEBI-B; Bleicher, 2004). A science teaching self-efficacy score was computed from the Personal Science Teaching Efficacy (PTSE) factor of the instrument. Using non-parametric statistics, no significant difference was found between teaching models, between genders, within models, among instructors, or among courses. The number of previous science courses was significantly correlated with PTSE score. Student responses to open-ended questions indicated that students felt the larger enrollment in the SCALE-UP room reduced individual teacher attention but that the large round SCALE-UP tables promoted group interaction. Students responded positively to cooperative and hands-on activities, and would encourage inclusion of more such activities in all of the courses. The large enrollment SCALE-UP model as implemented at the host university did not increase science teaching self-efficacy of non-science majors, as hypothesized. This was likely due to limited modification of standard cooperative activities according to the inquiry-guided SCALE-UP model. It was also found that larger SCALE-UP enrollments did not decrease science teaching self-efficacy when standard cooperative activities were used in the larger class.

  18. Large scale distribution of ultra high energy cosmic rays detected at the Pierre Auger Observatory with zenith angles up to 80°

    DOE PAGES

    Aab, Alexander

    2015-03-30

    In this study, we present the results of an analysis of the large angular scale distribution of the arrival directions of cosmic rays with energy above 4 EeV detected at the Pierre Auger Observatory including for the first time events with zenith angle between 60° and 80°. We perform two Rayleigh analyses, one in the right ascension and one in the azimuth angle distributions, that are sensitive to modulations in right ascension and declination, respectively. The largest departure from isotropy appears in themore » $$E\\gt 8$$ EeV energy bin, with an amplitude for the first harmonic in right ascension $$r_{1}^{\\alpha }=(4.4\\pm 1.0)\\times {{10}^{-2}}$$, that has a chance probability $$P(\\geqslant r_{1}^{\\alpha })=6.4\\times {{10}^{-5}}$$, reinforcing the hint previously reported with vertical events alone.« less

  19. Exhaustive identification of steady state cycles in large stoichiometric networks

    PubMed Central

    Wright, Jeremiah; Wagner, Andreas

    2008-01-01

    Background Identifying cyclic pathways in chemical reaction networks is important, because such cycles may indicate in silico violation of energy conservation, or the existence of feedback in vivo. Unfortunately, our ability to identify cycles in stoichiometric networks, such as signal transduction and genome-scale metabolic networks, has been hampered by the computational complexity of the methods currently used. Results We describe a new algorithm for the identification of cycles in stoichiometric networks, and we compare its performance to two others by exhaustively identifying the cycles contained in the genome-scale metabolic networks of H. pylori, M. barkeri, E. coli, and S. cerevisiae. Our algorithm can substantially decrease both the execution time and maximum memory usage in comparison to the two previous algorithms. Conclusion The algorithm we describe improves our ability to study large, real-world, biochemical reaction networks, although additional methodological improvements are desirable. PMID:18616835

  20. SureChEMBL: a large-scale, chemically annotated patent document database.

    PubMed

    Papadatos, George; Davies, Mark; Dedman, Nathan; Chambers, Jon; Gaulton, Anna; Siddle, James; Koks, Richard; Irvine, Sean A; Pettersson, Joe; Goncharoff, Nicko; Hersey, Anne; Overington, John P

    2016-01-04

    SureChEMBL is a publicly available large-scale resource containing compounds extracted from the full text, images and attachments of patent documents. The data are extracted from the patent literature according to an automated text and image-mining pipeline on a daily basis. SureChEMBL provides access to a previously unavailable, open and timely set of annotated compound-patent associations, complemented with sophisticated combined structure and keyword-based search capabilities against the compound repository and patent document corpus; given the wealth of knowledge hidden in patent documents, analysis of SureChEMBL data has immediate applications in drug discovery, medicinal chemistry and other commercial areas of chemical science. Currently, the database contains 17 million compounds extracted from 14 million patent documents. Access is available through a dedicated web-based interface and data downloads at: https://www.surechembl.org/. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

  1. Remote Sensing Contributions to Prediction and Risk Assessment of Natural Disasters Caused by Large Scale Rift Valley Fever Outbreaks

    NASA Technical Reports Server (NTRS)

    Anyamba, Assaf; Linthicum, Kenneth J.; Small, Jennifer; Britch, S. C.; Tucker, C. J.

    2012-01-01

    Remotely sensed vegetation measurements for the last 30 years combined with other climate data sets such as rainfall and sea surface temperatures have come to play an important role in the study of the ecology of arthropod-borne diseases. We show that epidemics and epizootics of previously unpredictable Rift Valley fever are directly influenced by large scale flooding associated with the El Ni o/Southern Oscillation. This flooding affects the ecology of disease transmitting arthropod vectors through vegetation development and other bioclimatic factors. This information is now utilized to monitor, model, and map areas of potential Rift Valley fever outbreaks and is used as an early warning system for risk reduction of outbreaks to human and animal health, trade, and associated economic impacts. The continuation of such satellite measurements is critical to anticipating, preventing, and managing disease epidemics and epizootics and other climate-related disasters.

  2. Hybrid baryons in QCD

    DOE PAGES

    Dudek, Jozef J.; Edwards, Robert G.

    2012-03-21

    In this study, we present the first comprehensive study of hybrid baryons using lattice QCD methods. Using a large basis of composite QCD interpolating fields we extract an extensive spectrum of baryon states and isolate those of hybrid character using their relatively large overlap onto operators which sample gluonic excitations. We consider the spectrum of Nucleon and Delta states at several quark masses finding a set of positive parity hybrid baryons with quantum numbersmore » $$N_{1/2^+},\\,N_{1/2^+},\\,N_{3/2^+},\\, N_{3/2^+},\\,N_{5/2^+},\\,$$ and $$\\Delta_{1/2^+},\\, \\Delta_{3/2^+}$$ at an energy scale above the first band of `conventional' excited positive parity baryons. This pattern of states is compatible with a color octet gluonic excitation having $$J^{P}=1^{+}$$ as previously reported in the hybrid meson sector and with a comparable energy scale for the excitation, suggesting a common bound-state construction for hybrid mesons and baryons.« less

  3. Unfolding large-scale online collaborative human dynamics

    PubMed Central

    Zha, Yilong; Zhou, Tao; Zhou, Changsong

    2016-01-01

    Large-scale interacting human activities underlie all social and economic phenomena, but quantitative understanding of regular patterns and mechanism is very challenging and still rare. Self-organized online collaborative activities with a precise record of event timing provide unprecedented opportunity. Our empirical analysis of the history of millions of updates in Wikipedia shows a universal double–power-law distribution of time intervals between consecutive updates of an article. We then propose a generic model to unfold collaborative human activities into three modules: (i) individual behavior characterized by Poissonian initiation of an action, (ii) human interaction captured by a cascading response to previous actions with a power-law waiting time, and (iii) population growth due to the increasing number of interacting individuals. This unfolding allows us to obtain an analytical formula that is fully supported by the universal patterns in empirical data. Our modeling approaches reveal “simplicity” beyond complex interacting human activities. PMID:27911766

  4. Health support for the Raid of the Seven Stones : in the footsteps of Navy physician Jules Crevaux in French Guiana.

    PubMed

    Barthes, N; Boudsocq, J-P

    2017-06-01

    In the summer of 2015, soldiers of the 3rd Foreign Infantry Regiment and civilian scientists mounted a joint expedition on foot to reconnoiter and better define the southern frontier of French Guiana with Brazil. Three doctor-nurse pairs worked in relay to provide medical support for this unprecedented 42-day, 320-km journey through a hostile and isolated environment, a mission whose success was made possible by large-scale logistic and technical prowess. The army health department, using knowledge gained from previous large-scale missions and expeditions and from its staff's local experience, provided its technical support for personnel selection, organization of the health logistics, and field support. This article describes the difficulties encountered from a medical perspective, the diseases encountered, and the final assessments of the personnel who completed this expedition.

  5. Impact of tissue atrophy on high-pass filtered MRI signal phase-based assessment in large-scale group-comparison studies: A simulation study

    NASA Astrophysics Data System (ADS)

    Schweser, Ferdinand; Dwyer, Michael G.; Deistung, Andreas; Reichenbach, Jürgen R.; Zivadinov, Robert

    2013-10-01

    The assessment of abnormal accumulation of tissue iron in the basal ganglia nuclei and in white matter plaques using the gradient echo magnetic resonance signal phase has become a research focus in many neurodegenerative diseases such as multiple sclerosis or Parkinson’s disease. A common and natural approach is to calculate the mean high-pass-filtered phase of previously delineated brain structures. Unfortunately, the interpretation of such an analysis requires caution: in this paper we demonstrate that regional gray matter atrophy, which is concomitant with many neurodegenerative diseases, may itself directly result in a phase shift seemingly indicative of increased iron concentration even without any real change in the tissue iron concentration. Although this effect is relatively small results of large-scale group comparisons may be driven by anatomical changes rather than by changes of the iron concentration.

  6. Multidimensional quantum entanglement with large-scale integrated optics.

    PubMed

    Wang, Jianwei; Paesani, Stefano; Ding, Yunhong; Santagati, Raffaele; Skrzypczyk, Paul; Salavrakos, Alexia; Tura, Jordi; Augusiak, Remigiusz; Mančinska, Laura; Bacco, Davide; Bonneau, Damien; Silverstone, Joshua W; Gong, Qihuang; Acín, Antonio; Rottwitt, Karsten; Oxenløwe, Leif K; O'Brien, Jeremy L; Laing, Anthony; Thompson, Mark G

    2018-04-20

    The ability to control multidimensional quantum systems is central to the development of advanced quantum technologies. We demonstrate a multidimensional integrated quantum photonic platform able to generate, control, and analyze high-dimensional entanglement. A programmable bipartite entangled system is realized with dimensions up to 15 × 15 on a large-scale silicon photonics quantum circuit. The device integrates more than 550 photonic components on a single chip, including 16 identical photon-pair sources. We verify the high precision, generality, and controllability of our multidimensional technology, and further exploit these abilities to demonstrate previously unexplored quantum applications, such as quantum randomness expansion and self-testing on multidimensional states. Our work provides an experimental platform for the development of multidimensional quantum technologies. Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

  7. Large-scale galactic motions: test of the Dipole Repeller model with the RFGC galaxies data

    NASA Astrophysics Data System (ADS)

    Parnovsky, S.

    2017-06-01

    The paper "The Dipole Repeller" in Nature Astronomy by Hoffman et al. state that the local large-scale galactic flow is dominated by a single attractor - associated with the Shapley Concentration - and a single previously unidentified repeller. We check this hypothesis using the data for 1459 galaxies from RFGC catalogue with distances up to 100 h-1 Mpc. We compared the models with multipole velocity field for pure Hubble expansion and dipole, quadrupole and octopole motion with the models with two attractors in the regions indicated by Hoffman et al with the multipole velocity field background. The results do not support the hypothesis, but does not contradict it. In any case, the inclusion of the following multipole is more effective than the addition of two attractors. Estimations of excess mass of attractors vary greatly, even changing their sign depending on the highest multipole used in model.

  8. Large scale extraction of poly(3-hydroxybutyrate) from Ralstonia eutropha H16 using sodium hypochlorite

    PubMed Central

    2012-01-01

    Isolation of polyhydroxyalkanoates (PHAs) from bacterial cell matter is a critical step in order to achieve a profitable production of the polymer. Therefore, an extraction method must lead to a high recovery of a pure product at low costs. This study presents a simplified method for large scale poly(3-hydroxybutyrate), poly(3HB), extraction using sodium hypochlorite. Poly(3HB) was extracted from cells of Ralstonia eutropha H16 at almost 96% purity. At different extraction volumes, a maximum recovery rate of 91.32% was obtained. At the largest extraction volume of 50 L, poly(3HB) with an average purity of 93.32% ± 4.62% was extracted with a maximum recovery of 87.03% of the initial poly(3HB) content. This process is easy to handle and requires less efforts than previously described processes. PMID:23164136

  9. Ten per cent polarized optical emission from GRB 090102.

    PubMed

    Steele, I A; Mundell, C G; Smith, R J; Kobayashi, S; Guidorzi, C

    2009-12-10

    The nature of the jets and the role of magnetic fields in gamma-ray bursts (GRBs) remains unclear. In a baryon-dominated jet only weak, tangled fields generated in situ through shocks would be present. In an alternative model, jets are threaded with large-scale magnetic fields that originate at the central engine and that accelerate and collimate the material. To distinguish between the models the degree of polarization in early-time emission must be measured; however, previous claims of gamma-ray polarization have been controversial. Here we report that the early optical emission from GRB 090102 was polarized at 10 +/- 1 per cent, indicating the presence of large-scale fields originating in the expanding fireball. If the degree of polarization and its position angle were variable on timescales shorter than our 60-second exposure, then the peak polarization may have been larger than ten per cent.

  10. The cosmic spiderweb: equivalence of cosmic, architectural and origami tessellations.

    PubMed

    Neyrinck, Mark C; Hidding, Johan; Konstantatou, Marina; van de Weygaert, Rien

    2018-04-01

    For over 20 years, the term 'cosmic web' has guided our understanding of the large-scale arrangement of matter in the cosmos, accurately evoking the concept of a network of galaxies linked by filaments. But the physical correspondence between the cosmic web and structural engineering or textile 'spiderwebs' is even deeper than previously known, and also extends to origami tessellations. Here, we explain that in a good structure-formation approximation known as the adhesion model, threads of the cosmic web form a spiderweb, i.e. can be strung up to be entirely in tension. The correspondence is exact if nodes sampling voids are included, and if structure is excluded within collapsed regions (walls, filaments and haloes), where dark-matter multistreaming and baryonic physics affect the structure. We also suggest how concepts arising from this link might be used to test cosmological models: for example, to test for large-scale anisotropy and rotational flows in the cosmos.

  11. The cosmic spiderweb: equivalence of cosmic, architectural and origami tessellations

    NASA Astrophysics Data System (ADS)

    Neyrinck, Mark C.; Hidding, Johan; Konstantatou, Marina; van de Weygaert, Rien

    2018-04-01

    For over 20 years, the term `cosmic web' has guided our understanding of the large-scale arrangement of matter in the cosmos, accurately evoking the concept of a network of galaxies linked by filaments. But the physical correspondence between the cosmic web and structural engineering or textile `spiderwebs' is even deeper than previously known, and also extends to origami tessellations. Here, we explain that in a good structure-formation approximation known as the adhesion model, threads of the cosmic web form a spiderweb, i.e. can be strung up to be entirely in tension. The correspondence is exact if nodes sampling voids are included, and if structure is excluded within collapsed regions (walls, filaments and haloes), where dark-matter multistreaming and baryonic physics affect the structure. We also suggest how concepts arising from this link might be used to test cosmological models: for example, to test for large-scale anisotropy and rotational flows in the cosmos.

  12. Occurrence of Veterinary Antibiotics in Swine Manure from Large-scale Feedlots in Zhejiang Province, China.

    PubMed

    Wang, Hua; Chu, Yixuan; Fang, Chengran

    2017-04-01

    The occurrence and distribution of five sulfonamides and three tetracyclines in swine manure sampled from large-scale feedlots in different areas of Zhejiang Province, China were detected using solid-phase extraction and high-performance liquid chromatography. All eight test antibiotics were detected in most of the manure samples. The dominant antibiotics in swine manure were sulfadiazine, sulfamerazine, sulfadimidine, tetracycline, and chlortetracycline. The maximum concentration of residual antibiotic reached up to 57.95 mg/kg (chlortetracycline). The concentrations and distribution of both types of antibiotics in swine manure of different areas varied greatly. Relatively higher concentrations of sulfonamides were found in swine manure from the Zhejiang area in this experiment compared with previous studies. The results revealed that antibiotics were extensively used in feedlots in this district and that animal manure might act as a non-specific source of antibiotic residues in farmlands and aquatic environments.

  13. Preconditioning strategies for nonlinear conjugate gradient methods, based on quasi-Newton updates

    NASA Astrophysics Data System (ADS)

    Andrea, Caliciotti; Giovanni, Fasano; Massimo, Roma

    2016-10-01

    This paper reports two proposals of possible preconditioners for the Nonlinear Conjugate Gradient (NCG) method, in large scale unconstrained optimization. On one hand, the common idea of our preconditioners is inspired to L-BFGS quasi-Newton updates, on the other hand we aim at explicitly approximating in some sense the inverse of the Hessian matrix. Since we deal with large scale optimization problems, we propose matrix-free approaches where the preconditioners are built using symmetric low-rank updating formulae. Our distinctive new contributions rely on using information on the objective function collected as by-product of the NCG, at previous iterations. Broadly speaking, our first approach exploits the secant equation, in order to impose interpolation conditions on the objective function. In the second proposal we adopt and ad hoc modified-secant approach, in order to possibly guarantee some additional theoretical properties.

  14. SureChEMBL: a large-scale, chemically annotated patent document database

    PubMed Central

    Papadatos, George; Davies, Mark; Dedman, Nathan; Chambers, Jon; Gaulton, Anna; Siddle, James; Koks, Richard; Irvine, Sean A.; Pettersson, Joe; Goncharoff, Nicko; Hersey, Anne; Overington, John P.

    2016-01-01

    SureChEMBL is a publicly available large-scale resource containing compounds extracted from the full text, images and attachments of patent documents. The data are extracted from the patent literature according to an automated text and image-mining pipeline on a daily basis. SureChEMBL provides access to a previously unavailable, open and timely set of annotated compound-patent associations, complemented with sophisticated combined structure and keyword-based search capabilities against the compound repository and patent document corpus; given the wealth of knowledge hidden in patent documents, analysis of SureChEMBL data has immediate applications in drug discovery, medicinal chemistry and other commercial areas of chemical science. Currently, the database contains 17 million compounds extracted from 14 million patent documents. Access is available through a dedicated web-based interface and data downloads at: https://www.surechembl.org/. PMID:26582922

  15. A Normalization-Free and Nonparametric Method Sharpens Large-Scale Transcriptome Analysis and Reveals Common Gene Alteration Patterns in Cancers.

    PubMed

    Li, Qi-Gang; He, Yong-Han; Wu, Huan; Yang, Cui-Ping; Pu, Shao-Yan; Fan, Song-Qing; Jiang, Li-Ping; Shen, Qiu-Shuo; Wang, Xiao-Xiong; Chen, Xiao-Qiong; Yu, Qin; Li, Ying; Sun, Chang; Wang, Xiangting; Zhou, Jumin; Li, Hai-Peng; Chen, Yong-Bin; Kong, Qing-Peng

    2017-01-01

    Heterogeneity in transcriptional data hampers the identification of differentially expressed genes (DEGs) and understanding of cancer, essentially because current methods rely on cross-sample normalization and/or distribution assumption-both sensitive to heterogeneous values. Here, we developed a new method, Cross-Value Association Analysis (CVAA), which overcomes the limitation and is more robust to heterogeneous data than the other methods. Applying CVAA to a more complex pan-cancer dataset containing 5,540 transcriptomes discovered numerous new DEGs and many previously rarely explored pathways/processes; some of them were validated, both in vitro and in vivo , to be crucial in tumorigenesis, e.g., alcohol metabolism ( ADH1B ), chromosome remodeling ( NCAPH ) and complement system ( Adipsin ). Together, we present a sharper tool to navigate large-scale expression data and gain new mechanistic insights into tumorigenesis.

  16. Ultra-stiff large-area carpets of carbon nanotubes

    NASA Astrophysics Data System (ADS)

    Meysami, Seyyed Shayan; Dallas, Panagiotis; Britton, Jude; Lozano, Juan G.; Murdock, Adrian T.; Ferraro, Claudio; Gutierrez, Eduardo Saiz; Rijnveld, Niek; Holdway, Philip; Porfyrakis, Kyriakos; Grobert, Nicole

    2016-06-01

    Herewith, we report the influence of post-synthesis heat treatment (<=2350 °C and plasma temperatures) on the crystal structure, defect density, purity, alignment and dispersibility of free-standing large-area (several cm2) carpets of ultra-long (several mm) vertically aligned multi-wall carbon nanotubes (VA-MWCNTs). VA-MWCNTs were produced in large quantities (20-30 g per batch) using a semi-scaled-up aerosol-assisted chemical vapour deposition (AACVD) setup. Electron and X-ray diffraction showed that the heat treatment at 2350 °C under inert atmosphere purifies, removes residual catalyst particles, and partially aligns adjacent single crystals (crystallites) in polycrystalline MWCNTs. The purification and improvement in the crystallites alignment within the MWCNTs resulted in reduced dispersibility of the VA-MWCNTs in liquid media. High-resolution microscopy revealed that the crystallinity is improved in scales of few tens of nanometres while the point defects remain largely unaffected. The heat treatment also had a marked benefit on the mechanical properties of the carpets. For the first time, we report compression moduli as high as 120 MPa for VA-MWCNT carpets, i.e. an order of magnitude higher than previously reported figures. The application of higher temperatures (arc-discharge plasma, >=4000 °C) resulted in the formation of a novel graphite-matrix composite reinforced with CVD and arc-discharge-like carbon nanotubes.Herewith, we report the influence of post-synthesis heat treatment (<=2350 °C and plasma temperatures) on the crystal structure, defect density, purity, alignment and dispersibility of free-standing large-area (several cm2) carpets of ultra-long (several mm) vertically aligned multi-wall carbon nanotubes (VA-MWCNTs). VA-MWCNTs were produced in large quantities (20-30 g per batch) using a semi-scaled-up aerosol-assisted chemical vapour deposition (AACVD) setup. Electron and X-ray diffraction showed that the heat treatment at 2350 °C under inert atmosphere purifies, removes residual catalyst particles, and partially aligns adjacent single crystals (crystallites) in polycrystalline MWCNTs. The purification and improvement in the crystallites alignment within the MWCNTs resulted in reduced dispersibility of the VA-MWCNTs in liquid media. High-resolution microscopy revealed that the crystallinity is improved in scales of few tens of nanometres while the point defects remain largely unaffected. The heat treatment also had a marked benefit on the mechanical properties of the carpets. For the first time, we report compression moduli as high as 120 MPa for VA-MWCNT carpets, i.e. an order of magnitude higher than previously reported figures. The application of higher temperatures (arc-discharge plasma, >=4000 °C) resulted in the formation of a novel graphite-matrix composite reinforced with CVD and arc-discharge-like carbon nanotubes. Electronic supplementary information (ESI) available. See DOI: 10.1039/c6nr01660j

  17. Hemispheric Asymmetries in Substorm Recovery Time Scales

    NASA Technical Reports Server (NTRS)

    Fillingim, M. O.; Chua, D H.; Germany, G. A.; Spann, James F.

    2009-01-01

    Previous statistical observations have shown that the recovery time scales of substorms occurring in the winter and near equinox (when the nighttime auroral zone was in darkness) are roughly twice as long as the recovery time scales for substorms occurring in the summer (when the nighttime auroral region was sunlit). This suggests that auroral substorms in the northern and southern hemispheres develop asymmetrically during solstice conditions with substorms lasting longer in the winter (dark) hemisphere than in the summer (sunlit) hemisphere. Additionally, this implies that more energy is deposited by electron precipitation in the winter hemisphere than in the summer one during substorms. This result, coupled with previous observations that have shown that auroral activity is more common when the ionosphere is in darkness and is suppressed when the ionosphere is in daylight, strongly suggests that the ionospheric conductivity plays an important role governing how magnetospheric energy is transferred to the ionosphere during substorms. Therefore, the ionosphere itself may dictate how much energy it will accept from the magnetosphere during substorms rather than this being an externally imposed quantity. Here, we extend our earlier work by statistically analyzing the recovery time scales for a large number of substorms observed in the conjugate hemispheres simultaneously by two orbiting global auroral imagers: Polar UVI and IMAGE FUV. Our current results are consistent with previous observations. The recovery time scales are observed to be longer in the winter (dark) hemisphere while the auroral activity has a shorter duration in the summer (sunlit) hemisphere. This leads to an asymmetric energy input from the magnetosphere to the ionosphere with more energy being deposited in the winter hemisphere than in the summer hemisphere.

  18. Innovative Visualizations Shed Light on Avian Nocturnal Migration

    PubMed Central

    Farnsworth, Andrew; Aelterman, Bart; Alves, Jose A.; Azijn, Kevin; Bernstein, Garrett; Branco, Sérgio; Desmet, Peter; Dokter, Adriaan M.; Horton, Kyle; Kelling, Steve; Kelly, Jeffrey F.; Leijnse, Hidde; Rong, Jingjing; Sheldon, Daniel; Van den Broeck, Wouter; Van Den Meersche, Jan Klaas; Van Doren, Benjamin Mark; van Gasteren, Hans

    2016-01-01

    Globally, billions of flying animals undergo seasonal migrations, many of which occur at night. The temporal and spatial scales at which migrations occur and our inability to directly observe these nocturnal movements makes monitoring and characterizing this critical period in migratory animals’ life cycles difficult. Remote sensing, therefore, has played an important role in our understanding of large-scale nocturnal bird migrations. Weather surveillance radar networks in Europe and North America have great potential for long-term low-cost monitoring of bird migration at scales that have previously been impossible to achieve. Such long-term monitoring, however, poses a number of challenges for the ornithological and ecological communities: how does one take advantage of this vast data resource, integrate information across multiple sensors and large spatial and temporal scales, and visually represent the data for interpretation and dissemination, considering the dynamic nature of migration? We assembled an interdisciplinary team of ecologists, meteorologists, computer scientists, and graphic designers to develop two different flow visualizations, which are interactive and open source, in order to create novel representations of broad-front nocturnal bird migration to address a primary impediment to long-term, large-scale nocturnal migration monitoring. We have applied these visualization techniques to mass bird migration events recorded by two different weather surveillance radar networks covering regions in Europe and North America. These applications show the flexibility and portability of such an approach. The visualizations provide an intuitive representation of the scale and dynamics of these complex systems, are easily accessible for a broad interest group, and are biologically insightful. Additionally, they facilitate fundamental ecological research, conservation, mitigation of human–wildlife conflicts, improvement of meteorological products, and public outreach, education, and engagement. PMID:27557096

  19. Innovative Visualizations Shed Light on Avian Nocturnal Migration.

    PubMed

    Shamoun-Baranes, Judy; Farnsworth, Andrew; Aelterman, Bart; Alves, Jose A; Azijn, Kevin; Bernstein, Garrett; Branco, Sérgio; Desmet, Peter; Dokter, Adriaan M; Horton, Kyle; Kelling, Steve; Kelly, Jeffrey F; Leijnse, Hidde; Rong, Jingjing; Sheldon, Daniel; Van den Broeck, Wouter; Van Den Meersche, Jan Klaas; Van Doren, Benjamin Mark; van Gasteren, Hans

    2016-01-01

    Globally, billions of flying animals undergo seasonal migrations, many of which occur at night. The temporal and spatial scales at which migrations occur and our inability to directly observe these nocturnal movements makes monitoring and characterizing this critical period in migratory animals' life cycles difficult. Remote sensing, therefore, has played an important role in our understanding of large-scale nocturnal bird migrations. Weather surveillance radar networks in Europe and North America have great potential for long-term low-cost monitoring of bird migration at scales that have previously been impossible to achieve. Such long-term monitoring, however, poses a number of challenges for the ornithological and ecological communities: how does one take advantage of this vast data resource, integrate information across multiple sensors and large spatial and temporal scales, and visually represent the data for interpretation and dissemination, considering the dynamic nature of migration? We assembled an interdisciplinary team of ecologists, meteorologists, computer scientists, and graphic designers to develop two different flow visualizations, which are interactive and open source, in order to create novel representations of broad-front nocturnal bird migration to address a primary impediment to long-term, large-scale nocturnal migration monitoring. We have applied these visualization techniques to mass bird migration events recorded by two different weather surveillance radar networks covering regions in Europe and North America. These applications show the flexibility and portability of such an approach. The visualizations provide an intuitive representation of the scale and dynamics of these complex systems, are easily accessible for a broad interest group, and are biologically insightful. Additionally, they facilitate fundamental ecological research, conservation, mitigation of human-wildlife conflicts, improvement of meteorological products, and public outreach, education, and engagement.

  20. FAST MAGNETIC FIELD AMPLIFICATION IN THE EARLY UNIVERSE: GROWTH OF COLLISIONLESS PLASMA INSTABILITIES IN TURBULENT MEDIA

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Falceta-Gonçalves, D.; Kowal, G.

    2015-07-20

    In this work we report on a numerical study of the cosmic magnetic field amplification due to collisionless plasma instabilities. The collisionless magnetohydrodynamic equations derived account for the pressure anisotropy that leads, in specific conditions, to the firehose and mirror instabilities. We study the time evolution of seed fields in turbulence under the influence of such instabilities. An approximate analytical time evolution of the magnetic field is provided. The numerical simulations and the analytical predictions are compared. We found that (i) amplification of the magnetic field was efficient in firehose-unstable turbulent regimes, but not in the mirror-unstable models; (ii) the growthmore » rate of the magnetic energy density is much faster than the turbulent dynamo; and (iii) the efficient amplification occurs at small scales. The analytical prediction for the correlation between the growth timescales and pressure anisotropy is confirmed by the numerical simulations. These results reinforce the idea that pressure anisotropies—driven naturally in a turbulent collisionless medium, e.g., the intergalactic medium, could efficiently amplify the magnetic field in the early universe (post-recombination era), previous to the collapse of the first large-scale gravitational structures. This mechanism, though fast for the small-scale fields (∼kpc scales), is unable to provide relatively strong magnetic fields at large scales. Other mechanisms that were not accounted for here (e.g., collisional turbulence once instabilities are quenched, velocity shear, or gravitationally induced inflows of gas into galaxies and clusters) could operate afterward to build up large-scale coherent field structures in the long time evolution.« less

  1. Multi-resolution anisotropy studies of ultrahigh-energy cosmic rays detected at the Pierre Auger Observatory

    NASA Astrophysics Data System (ADS)

    Aab, A.; Abreu, P.; Aglietta, M.; Samarai, I. Al; Albuquerque, I. F. M.; Allekotte, I.; Almela, A.; Alvarez Castillo, J.; Alvarez-Muñiz, J.; Anastasi, G. A.; Anchordoqui, L.; Andrada, B.; Andringa, S.; Aramo, C.; Arqueros, F.; Arsene, N.; Asorey, H.; Assis, P.; Aublin, J.; Avila, G.; Badescu, A. M.; Balaceanu, A.; Barreira Luz, R. J.; Baus, C.; Beatty, J. J.; Becker, K. H.; Bellido, J. A.; Berat, C.; Bertaina, M. E.; Bertou, X.; Biermann, P. L.; Billoir, P.; Biteau, J.; Blaess, S. G.; Blanco, A.; Blazek, J.; Bleve, C.; Boháčová, M.; Boncioli, D.; Bonifazi, C.; Borodai, N.; Botti, A. M.; Brack, J.; Brancus, I.; Bretz, T.; Bridgeman, A.; Briechle, F. L.; Buchholz, P.; Bueno, A.; Buitink, S.; Buscemi, M.; Caballero-Mora, K. S.; Caccianiga, L.; Cancio, A.; Canfora, F.; Caramete, L.; Caruso, R.; Castellina, A.; Cataldi, G.; Cazon, L.; Chavez, A. G.; Chinellato, J. A.; Chudoba, J.; Clay, R. W.; Colalillo, R.; Coleman, A.; Collica, L.; Coluccia, M. R.; Conceição, R.; Contreras, F.; Cooper, M. J.; Coutu, S.; Covault, C. E.; Cronin, J.; D'Amico, S.; Daniel, B.; Dasso, S.; Daumiller, K.; Dawson, B. R.; de Almeida, R. M.; de Jong, S. J.; De Mauro, G.; de Mello Neto, J. R. T.; De Mitri, I.; de Oliveira, J.; de Souza, V.; Debatin, J.; Deligny, O.; Di Giulio, C.; Di Matteo, A.; Díaz Castro, M. L.; Diogo, F.; Dobrigkeit, C.; D'Olivo, J. C.; dos Anjos, R. C.; Dova, M. T.; Dundovic, A.; Ebr, J.; Engel, R.; Erdmann, M.; Erfani, M.; Escobar, C. O.; Espadanal, J.; Etchegoyen, A.; Falcke, H.; Farrar, G.; Fauth, A. C.; Fazzini, N.; Fick, B.; Figueira, J. M.; Filipčič, A.; Fratu, O.; Freire, M. M.; Fujii, T.; Fuster, A.; Gaior, R.; García, B.; Garcia-Pinto, D.; Gaté, F.; Gemmeke, H.; Gherghel-Lascu, A.; Ghia, P. L.; Giaccari, U.; Giammarchi, M.; Giller, M.; Głas, D.; Glaser, C.; Golup, G.; Gómez Berisso, M.; Gómez Vitale, P. F.; González, N.; Gorgi, A.; Gorham, P.; Gouffon, P.; Grillo, A. F.; Grubb, T. D.; Guarino, F.; Guedes, G. P.; Hampel, M. R.; Hansen, P.; Harari, D.; Harrison, T. A.; Harton, J. L.; Hasankiadeh, Q.; Haungs, A.; Hebbeker, T.; Heck, D.; Heimann, P.; Herve, A. E.; Hill, G. C.; Hojvat, C.; Holt, E.; Homola, P.; Hörandel, J. R.; Horvath, P.; Hrabovský, M.; Huege, T.; Hulsman, J.; Insolia, A.; Isar, P. G.; Jandt, I.; Jansen, S.; Johnsen, J. A.; Josebachuili, M.; Kääpä, A.; Kambeitz, O.; Kampert, K. H.; Katkov, I.; Keilhauer, B.; Kemp, E.; Kemp, J.; Kieckhafer, R. M.; Klages, H. O.; Kleifges, M.; Kleinfeller, J.; Krause, R.; Krohm, N.; Kuempel, D.; Kukec Mezek, G.; Kunka, N.; Kuotb Awad, A.; LaHurd, D.; Lauscher, M.; Legumina, R.; Leigui de Oliveira, M. A.; Letessier-Selvon, A.; Lhenry-Yvon, I.; Link, K.; Lopes, L.; López, R.; López Casado, A.; Luce, Q.; Lucero, A.; Malacari, M.; Mallamaci, M.; Mandat, D.; Mantsch, P.; Mariazzi, A. G.; Mariş, I. C.; Marsella, G.; Martello, D.; Martinez, H.; Martínez Bravo, O.; Masías Meza, J. J.; Mathes, H. J.; Mathys, S.; Matthews, J.; Matthews, J. A. J.; Matthiae, G.; Mayotte, E.; Mazur, P. O.; Medina, C.; Medina-Tanco, G.; Melo, D.; Menshikov, A.; Messina, S.; Micheletti, M. I.; Middendorf, L.; Minaya, I. A.; Miramonti, L.; Mitrica, B.; Mockler, D.; Mollerach, S.; Montanet, F.; Morello, C.; Mostafá, M.; Müller, A. L.; Müller, G.; Muller, M. A.; Müller, S.; Mussa, R.; Naranjo, I.; Nellen, L.; Nguyen, P. H.; Niculescu-Oglinzanu, M.; Niechciol, M.; Niemietz, L.; Niggemann, T.; Nitz, D.; Nosek, D.; Novotny, V.; Nožka, H.; Núñez, L. A.; Ochilo, L.; Oikonomou, F.; Olinto, A.; Pakk Selmi-Dei, D.; Palatka, M.; Pallotta, J.; Papenbreer, P.; Parente, G.; Parra, A.; Paul, T.; Pech, M.; Pedreira, F.; Pȩkala, J.; Pelayo, R.; Peña-Rodriguez, J.; Pereira, L. A. S.; Perlín, M.; Perrone, L.; Peters, C.; Petrera, S.; Phuntsok, J.; Piegaia, R.; Pierog, T.; Pieroni, P.; Pimenta, M.; Pirronello, V.; Platino, M.; Plum, M.; Porowski, C.; Prado, R. R.; Privitera, P.; Prouza, M.; Quel, E. J.; Querchfeld, S.; Quinn, S.; Ramos-Pollan, R.; Rautenberg, J.; Ravignani, D.; Revenu, B.; Ridky, J.; Risse, M.; Ristori, P.; Rizi, V.; Rodrigues de Carvalho, W.; Rodriguez Fernandez, G.; Rodriguez Rojo, J.; Rogozin, D.; Roncoroni, M. J.; Roth, M.; Roulet, E.; Rovero, A. C.; Ruehl, P.; Saffi, S. J.; Saftoiu, A.; Salazar, H.; Saleh, A.; Salesa Greus, F.; Salina, G.; Sánchez, F.; Sanchez-Lucas, P.; Santos, E. M.; Santos, E.; Sarazin, F.; Sarmento, R.; Sarmiento, C. A.; Sato, R.; Schauer, M.; Scherini, V.; Schieler, H.; Schimp, M.; Schmidt, D.; Scholten, O.; Schovánek, P.; Schröder, F. G.; Schulz, A.; Schulz, J.; Schumacher, J.; Sciutto, S. J.; Segreto, A.; Settimo, M.; Shadkam, A.; Shellard, R. C.; Sigl, G.; Silli, G.; Sima, O.; Śmiałkowski, A.; Šmída, R.; Snow, G. R.; Sommers, P.; Sonntag, S.; Sorokin, J.; Squartini, R.; Stanca, D.; Stanič, S.; Stasielak, J.; Stassi, P.; Strafella, F.; Suarez, F.; Suarez Durán, M.; Sudholz, T.; Suomijärvi, T.; Supanitsky, A. D.; Swain, J.; Szadkowski, Z.; Taboada, A.; Taborda, O. A.; Tapia, A.; Theodoro, V. M.; Timmermans, C.; Todero Peixoto, C. J.; Tomankova, L.; Tomé, B.; Torralba Elipe, G.; Torri, M.; Travnicek, P.; Trini, M.; Ulrich, R.; Unger, M.; Urban, M.; Valdés Galicia, J. F.; Valiño, I.; Valore, L.; van Aar, G.; van Bodegom, P.; van den Berg, A. M.; van Vliet, A.; Varela, E.; Vargas Cárdenas, B.; Varner, G.; Vázquez, J. R.; Vázquez, R. A.; Veberič, D.; Vergara Quispe, I. D.; Verzi, V.; Vicha, J.; Villaseñor, L.; Vorobiov, S.; Wahlberg, H.; Wainberg, O.; Walz, D.; Watson, A. A.; Weber, M.; Weindl, A.; Wiencke, L.; Wilczyński, H.; Winchen, T.; Wittkowski, D.; Wundheiler, B.; Yang, L.; Yelos, D.; Yushkov, A.; Zas, E.; Zavrtanik, D.; Zavrtanik, M.; Zepeda, A.; Zimmermann, B.; Ziolkowski, M.; Zong, Z.; Zuccarello, F.

    2017-06-01

    We report a multi-resolution search for anisotropies in the arrival directions of cosmic rays detected at the Pierre Auger Observatory with local zenith angles up to 80o and energies in excess of 4 EeV (4 × 1018 eV). This search is conducted by measuring the angular power spectrum and performing a needlet wavelet analysis in two independent energy ranges. Both analyses are complementary since the angular power spectrum achieves a better performance in identifying large-scale patterns while the needlet wavelet analysis, considering the parameters used in this work, presents a higher efficiency in detecting smaller-scale anisotropies, potentially providing directional information on any observed anisotropies. No deviation from isotropy is observed on any angular scale in the energy range between 4 and 8 EeV. Above 8 EeV, an indication for a dipole moment is captured; while no other deviation from isotropy is observed for moments beyond the dipole one. The corresponding p-values obtained after accounting for searches blindly performed at several angular scales, are 1.3 × 10-5 in the case of the angular power spectrum, and 2.5 × 10-3 in the case of the needlet analysis. While these results are consistent with previous reports making use of the same data set, they provide extensions of the previous works through the thorough scans of the angular scales.

  2. Large-scale deep learning for robotically gathered imagery for science

    NASA Astrophysics Data System (ADS)

    Skinner, K.; Johnson-Roberson, M.; Li, J.; Iscar, E.

    2016-12-01

    With the explosion of computing power, the intelligence and capability of mobile robotics has dramatically increased over the last two decades. Today, we can deploy autonomous robots to achieve observations in a variety of environments ripe for scientific exploration. These platforms are capable of gathering a volume of data previously unimaginable. Additionally, optical cameras, driven by mobile phones and consumer photography, have rapidly improved in size, power consumption, and quality making their deployment cheaper and easier. Finally, in parallel we have seen the rise of large-scale machine learning approaches, particularly deep neural networks (DNNs), increasing the quality of the semantic understanding that can be automatically extracted from optical imagery. In concert this enables new science using a combination of machine learning and robotics. This work will discuss the application of new low-cost high-performance computing approaches and the associated software frameworks to enable scientists to rapidly extract useful science data from millions of robotically gathered images. The automated analysis of imagery on this scale opens up new avenues of inquiry unavailable using more traditional manual or semi-automated approaches. We will use a large archive of millions of benthic images gathered with an autonomous underwater vehicle to demonstrate how these tools enable new scientific questions to be posed.

  3. Population cycles are highly correlated over long time series and large spatial scales in two unrelated species: Greater sage-grouse and cottontail rabbits

    USGS Publications Warehouse

    Fedy, B.C.; Doherty, K.E.

    2011-01-01

    Animal species across multiple taxa demonstrate multi-annual population cycles, which have long been of interest to ecologists. Correlated population cycles between species that do not share a predator-prey relationship are particularly intriguing and challenging to explain. We investigated annual population trends of greater sage-grouse (Centrocercus urophasianus) and cottontail rabbits (Sylvilagus sp.) across Wyoming to explore the possibility of correlations between unrelated species, over multiple cycles, very large spatial areas, and relatively southern latitudes in terms of cycling species. We analyzed sage-grouse lek counts and annual hunter harvest indices from 1982 to 2007. We show that greater sage-grouse, currently listed as warranted but precluded under the US Endangered Species Act, and cottontails have highly correlated cycles (r = 0. 77). We explore possible mechanistic hypotheses to explain the synchronous population cycles. Our research highlights the importance of control populations in both adaptive management and impact studies. Furthermore, we demonstrate the functional value of these indices (lek counts and hunter harvest) for tracking broad-scale fluctuations in the species. This level of highly correlated long-term cycling has not previously been documented between two non-related species, over a long time-series, very large spatial scale, and within more southern latitudes. ?? 2010 US Government.

  4. Transformation of social networks in the late pre-Hispanic US Southwest.

    PubMed

    Mills, Barbara J; Clark, Jeffery J; Peeples, Matthew A; Haas, W R; Roberts, John M; Hill, J Brett; Huntley, Deborah L; Borck, Lewis; Breiger, Ronald L; Clauset, Aaron; Shackley, M Steven

    2013-04-09

    The late pre-Hispanic period in the US Southwest (A.D. 1200-1450) was characterized by large-scale demographic changes, including long-distance migration and population aggregation. To reconstruct how these processes reshaped social networks, we compiled a comprehensive artifact database from major sites dating to this interval in the western Southwest. We combine social network analysis with geographic information systems approaches to reconstruct network dynamics over 250 y. We show how social networks were transformed across the region at previously undocumented spatial, temporal, and social scales. Using well-dated decorated ceramics, we track changes in network topology at 50-y intervals to show a dramatic shift in network density and settlement centrality from the northern to the southern Southwest after A.D. 1300. Both obsidian sourcing and ceramic data demonstrate that long-distance network relationships also shifted from north to south after migration. Surprisingly, social distance does not always correlate with spatial distance because of the presence of network relationships spanning long geographic distances. Our research shows how a large network in the southern Southwest grew and then collapsed, whereas networks became more fragmented in the northern Southwest but persisted. The study also illustrates how formal social network analysis may be applied to large-scale databases of material culture to illustrate multigenerational changes in network structure.

  5. Robust multi-site MR data processing: iterative optimization of bias correction, tissue classification, and registration.

    PubMed

    Young Kim, Eun; Johnson, Hans J

    2013-01-01

    A robust multi-modal tool, for automated registration, bias correction, and tissue classification, has been implemented for large-scale heterogeneous multi-site longitudinal MR data analysis. This work focused on improving the an iterative optimization framework between bias-correction, registration, and tissue classification inspired from previous work. The primary contributions are robustness improvements from incorporation of following four elements: (1) utilize multi-modal and repeated scans, (2) incorporate high-deformable registration, (3) use extended set of tissue definitions, and (4) use of multi-modal aware intensity-context priors. The benefits of these enhancements were investigated by a series of experiments with both simulated brain data set (BrainWeb) and by applying to highly-heterogeneous data from a 32 site imaging study with quality assessments through the expert visual inspection. The implementation of this tool is tailored for, but not limited to, large-scale data processing with great data variation with a flexible interface. In this paper, we describe enhancements to a joint registration, bias correction, and the tissue classification, that improve the generalizability and robustness for processing multi-modal longitudinal MR scans collected at multi-sites. The tool was evaluated by using both simulated and simulated and human subject MRI images. With these enhancements, the results showed improved robustness for large-scale heterogeneous MRI processing.

  6. The preparation and characterization of chitin and chitosan under large-scale submerged fermentation level using shrimp by-products as substrate.

    PubMed

    Zhang, Hongcai; Yun, Sanyue; Song, Lingling; Zhang, Yiwen; Zhao, Yanyun

    2017-03-01

    The crustacean shells of crabs and shrimps produces quantities of by-products, leading to seriously environmental pollution and human health problems during industrial processing, yet they turned into high-value useful products, such as chitin and chitosan. To prepare them under large-scale submerged fermentation level, shrimp shell powders (SSPs) was fermented by successive three-step fermentation of Serratia marcescens B742, Lactobacillus plantarum ATCC 8014 and Rhizopus japonicus M193 to extract chitin and chitosan based on previously optimal conditions. Moreover, the key parameters was investigated to monitor the changes of resulted products during fermentation process. The results showed that the yield of prepared chitin and chitosan reached 21.35 and 13.11% with the recovery rate of 74.67 and 63.42%, respectively. The degree of deacetylation (DDA) and molecular mass (MM) of produced chitosan were 81.23% and 512.06kDa, respectively. The obtained chitin and chitosan was characterized using Fourier transform infrared spectrometer (FT-IR) and X-ray diffraction (XRD) analysis. The established microbial fermentation method can be applied for the industrial large-scale production of chitin and chitosan, while the use of chemical reagents was significantly reduced. Copyright © 2016 Elsevier B.V. All rights reserved.

  7. Potential large scale production of meningococcal vaccines by stable overexpression of fHbp in the rice seeds.

    PubMed

    Ma, Jian; Wang, Yunpeng; Xu, Nuo; Jin, Libo; Liu, Jia; Xing, Shaochen; Li, Xiaokun

    2018-06-25

    Factor H binding protein (fHbp) is the most promising vaccine candidate against serogroup B of Neisseria meningitidis which is a major cause of morbidity and mortality in children. In order to facilitate large scale production of a commercial vaccine, we previously used transgenic Arabidopsis thaliana, but plant-derived fHbp is still far away from a commercial vaccine due to less biomass production. Herein, we presented an alternative route for the production of recombinant fHbp from the seeds of transgenic rice. The OsrfHbp gene encoding recombinant fHbp fused protein was introduced into the genome of rice via Agrobacterium-mediated transformation. The both stable integration and transcription of the foreign OsrfHbp were confirmed by Southern blotting and RT-PCR analysis respectively. Further, the expression of fHbp protein was measured by immunoblotting analysis and quantified by ELISA. The results indicated that fHbp was successfully expressed and the highest yield of fHbp was 0.52 ± 0.03% of TSP in the transgenic rice seeds. The purified fHbp protein showed good antigenicity and immunogenicity in the animal model. The results of this experiment offer a novel approach for large-scale production of plant-derived commercial vaccine fHbp. Copyright © 2018. Published by Elsevier Inc.

  8. A Scalable Cyberinfrastructure for Interactive Visualization of Terascale Microscopy Data

    PubMed Central

    Venkat, A.; Christensen, C.; Gyulassy, A.; Summa, B.; Federer, F.; Angelucci, A.; Pascucci, V.

    2017-01-01

    The goal of the recently emerged field of connectomics is to generate a wiring diagram of the brain at different scales. To identify brain circuitry, neuroscientists use specialized microscopes to perform multichannel imaging of labeled neurons at a very high resolution. CLARITY tissue clearing allows imaging labeled circuits through entire tissue blocks, without the need for tissue sectioning and section-to-section alignment. Imaging the large and complex non-human primate brain with sufficient resolution to identify and disambiguate between axons, in particular, produces massive data, creating great computational challenges to the study of neural circuits. Researchers require novel software capabilities for compiling, stitching, and visualizing large imagery. In this work, we detail the image acquisition process and a hierarchical streaming platform, ViSUS, that enables interactive visualization of these massive multi-volume datasets using a standard desktop computer. The ViSUS visualization framework has previously been shown to be suitable for 3D combustion simulation, climate simulation and visualization of large scale panoramic images. The platform is organized around a hierarchical cache oblivious data layout, called the IDX file format, which enables interactive visualization and exploration in ViSUS, scaling to the largest 3D images. In this paper we showcase the VISUS framework used in an interactive setting with the microscopy data. PMID:28638896

  9. A Scalable Cyberinfrastructure for Interactive Visualization of Terascale Microscopy Data.

    PubMed

    Venkat, A; Christensen, C; Gyulassy, A; Summa, B; Federer, F; Angelucci, A; Pascucci, V

    2016-08-01

    The goal of the recently emerged field of connectomics is to generate a wiring diagram of the brain at different scales. To identify brain circuitry, neuroscientists use specialized microscopes to perform multichannel imaging of labeled neurons at a very high resolution. CLARITY tissue clearing allows imaging labeled circuits through entire tissue blocks, without the need for tissue sectioning and section-to-section alignment. Imaging the large and complex non-human primate brain with sufficient resolution to identify and disambiguate between axons, in particular, produces massive data, creating great computational challenges to the study of neural circuits. Researchers require novel software capabilities for compiling, stitching, and visualizing large imagery. In this work, we detail the image acquisition process and a hierarchical streaming platform, ViSUS, that enables interactive visualization of these massive multi-volume datasets using a standard desktop computer. The ViSUS visualization framework has previously been shown to be suitable for 3D combustion simulation, climate simulation and visualization of large scale panoramic images. The platform is organized around a hierarchical cache oblivious data layout, called the IDX file format, which enables interactive visualization and exploration in ViSUS, scaling to the largest 3D images. In this paper we showcase the VISUS framework used in an interactive setting with the microscopy data.

  10. Weak Hydrological Sensitivity to Temperature Change over Land, Independent of Climate Forcing

    NASA Technical Reports Server (NTRS)

    Samset, B. H.; Myhre, G.; Forster, P. M.; Hodnebrog, O.; Andrews, T.; Boucher, O.; Faluvegi, G.; Flaeschner, D.; Kasoar, M.; Kharin, V.; hide

    2018-01-01

    We present the global and regional hydrological sensitivity (HS) to surface temperature changes, for perturbations to CO2, CH4, sulfate and black carbon concentrations, and solar irradiance. Based on results from ten climate models, we show how modeled global mean precipitation increases by 2-3% per kelvin of global mean surface warming, independent of driver, when the effects of rapid adjustments are removed. Previously reported differences in response between drivers are therefore mainly ascribable to rapid atmospheric adjustment processes. All models show a sharp contrast in behavior over land and over ocean, with a strong surface temperature-driven (slow) ocean HS of 3-5%/K, while the slow land HS is only 0-2%/K. Separating the response into convective and large-scale cloud processes, we find larger inter-model differences, in particular over land regions. Large-scale precipitation changes are most relevant at high latitudes, while the equatorial HS is dominated by convective precipitation changes. Black carbon stands out as the driver with the largest inter-model slow HS variability, and also the strongest contrast between a weak land and strong sea response. We identify a particular need for model investigations and observational constraints on convective precipitation in the Arctic, and large-scale precipitation around the Equator.

  11. Water transportation ability of flat-lying slabs in the mantle transition zone and implications for craton destruction

    NASA Astrophysics Data System (ADS)

    Wang, Zhensheng; Kusky, Timothy M.; Capitanio, Fabio A.

    2018-01-01

    Water transported by deep subduction to the mantle transition zone (MTZ) that is eventually released and migrates upwards is invoked as a likely cause for hydroweakening and cratonic lithosphere destruction. The destruction of the North China Craton (NCC) during the Mesozoic has been proposed to be related to hydroweakening. However, the source of water related to large-scale craton destruction in the NCC is poorly constrained. Some suggest that the water was mainly released from a flat-lying (or stagnating) slab in the MTZ, whereas others posit that most water was released from a previously existing strongly hydrous MTZ then perturbed by the stagnating subduction in the MTZ layer. In this study, we use numerical modeling to evaluate the water carrying ability of flat-lying slabs in the MTZ with different slab ages and water contents to simulate its maximum value and discuss its potential role on large-scale hydroweakening and craton destruction. Our results reveal that a single flat-lying slab in the MTZ cannot provide enough water for large-scale cratonic lithosphere hydroweakening and thinning. Water estimates invoked for craton destruction as experienced by the NCC can only be the result of long-term piling of multiple slabs in the MTZ or penetrating deeper into the lower mantle.

  12. A k-space method for acoustic propagation using coupled first-order equations in three dimensions.

    PubMed

    Tillett, Jason C; Daoud, Mohammad I; Lacefield, James C; Waag, Robert C

    2009-09-01

    A previously described two-dimensional k-space method for large-scale calculation of acoustic wave propagation in tissues is extended to three dimensions. The three-dimensional method contains all of the two-dimensional method features that allow accurate and stable calculation of propagation. These features are spectral calculation of spatial derivatives, temporal correction that produces exact propagation in a homogeneous medium, staggered spatial and temporal grids, and a perfectly matched boundary layer. Spectral evaluation of spatial derivatives is accomplished using a fast Fourier transform in three dimensions. This computational bottleneck requires all-to-all communication; execution time in a parallel implementation is therefore sensitive to node interconnect latency and bandwidth. Accuracy of the three-dimensional method is evaluated through comparisons with exact solutions for media having spherical inhomogeneities. Large-scale calculations in three dimensions were performed by distributing the nearly 50 variables per voxel that are used to implement the method over a cluster of computers. Two computer clusters used to evaluate method accuracy are compared. Comparisons of k-space calculations with exact methods including absorption highlight the need to model accurately the medium dispersion relationships, especially in large-scale media. Accurately modeled media allow the k-space method to calculate acoustic propagation in tissues over hundreds of wavelengths.

  13. The decay of isotropic magnetohydrodynamics turbulence and the effects of cross-helicity

    NASA Astrophysics Data System (ADS)

    Briard, Antoine; Gomez, Thomas

    2018-02-01

    Decaying homogeneous and isotropic magnetohydrodynamics (MHD) turbulence is investigated numerically at large Reynolds numbers thanks to the eddy-damped quasi-normal Markovian (EDQNM) approximation. Without any background mean magnetic field, the total energy spectrum scales as -3/2$ in the inertial range as a consequence of the modelling. Moreover, the total energy is shown, both analytically and numerically, to decay at the same rate as kinetic energy in hydrodynamic isotropic turbulence: this differs from a previous prediction, and thus physical arguments are proposed to reconcile both results. Afterwards, the MHD turbulence is made imbalanced by an initial non-zero cross-helicity. A spectral modelling is developed for the velocity-magnetic correlation in a general homogeneous framework, which reveals that cross-helicity can contain subtle anisotropic effects. In the inertial range, as the Reynolds number increases, the slope of the cross-helical spectrum becomes closer to -5/3$ than -2$ . Furthermore, the Elsässer spectra deviate from -3/2$ with cross-helicity at large Reynolds numbers. Regarding the pressure spectrum P$ , its kinetic and magnetic parts are found to scale with -2$ in the inertial range, whereas the part due to cross-helicity rather scales in -7/3$ . Finally, the two rd laws for the total energy and cross-helicity are assessed numerically at large Reynolds numbers.

  14. Transformation of social networks in the late pre-Hispanic US Southwest

    PubMed Central

    Mills, Barbara J.; Clark, Jeffery J.; Peeples, Matthew A.; Haas, W. R.; Roberts, John M.; Hill, J. Brett; Huntley, Deborah L.; Borck, Lewis; Breiger, Ronald L.; Clauset, Aaron; Shackley, M. Steven

    2013-01-01

    The late pre-Hispanic period in the US Southwest (A.D. 1200–1450) was characterized by large-scale demographic changes, including long-distance migration and population aggregation. To reconstruct how these processes reshaped social networks, we compiled a comprehensive artifact database from major sites dating to this interval in the western Southwest. We combine social network analysis with geographic information systems approaches to reconstruct network dynamics over 250 y. We show how social networks were transformed across the region at previously undocumented spatial, temporal, and social scales. Using well-dated decorated ceramics, we track changes in network topology at 50-y intervals to show a dramatic shift in network density and settlement centrality from the northern to the southern Southwest after A.D. 1300. Both obsidian sourcing and ceramic data demonstrate that long-distance network relationships also shifted from north to south after migration. Surprisingly, social distance does not always correlate with spatial distance because of the presence of network relationships spanning long geographic distances. Our research shows how a large network in the southern Southwest grew and then collapsed, whereas networks became more fragmented in the northern Southwest but persisted. The study also illustrates how formal social network analysis may be applied to large-scale databases of material culture to illustrate multigenerational changes in network structure. PMID:23530201

  15. The CIDA-QUEST large-scale survey of Orion OB1: evidence for rapid disk dissipation in a dispersed stellar population.

    PubMed

    Briceño, C; Vivas, A K; Calvet, N; Hartmann, L; Pacheco, R; Herrera, D; Romero, L; Berlind, P; Sánchez, G; Snyder, J A; Andrews, P

    2001-01-05

    We are conducting a large-scale, multiepoch, optical photometric survey [Centro de Investigaciones de Astronomia-Quasar Equatorial Survey Team (CIDA-QUEST)] covering about 120 square degrees to identify the young low-mass stars in the Orion OB1 association. We present results for an area of 34 square degrees. Using photometric variability as our main selection criterion, as well as follow-up spectroscopy, we confirmed 168 previously unidentified pre-main sequence stars that are about 0.6 to 0.9 times the mass of the sun (Mo), with ages of about 1 million to 3 million years (Ori OB1b) and about 3 million to 10 million years (Ori OB1a). The low-mass stars are spatially coincident with the high-mass (at least 3 Mo) members of the associations. Indicators of disk accretion such as Halpha emission and near-infrared emission from dusty disks fall sharply from Ori OB1b to Ori OB1a, indicating that the time scale for disk dissipation and possibly the onset of planet formation is a few million years.

  16. Neuromorphic Hardware Architecture Using the Neural Engineering Framework for Pattern Recognition.

    PubMed

    Wang, Runchun; Thakur, Chetan Singh; Cohen, Gregory; Hamilton, Tara Julia; Tapson, Jonathan; van Schaik, Andre

    2017-06-01

    We present a hardware architecture that uses the neural engineering framework (NEF) to implement large-scale neural networks on field programmable gate arrays (FPGAs) for performing massively parallel real-time pattern recognition. NEF is a framework that is capable of synthesising large-scale cognitive systems from subnetworks and we have previously presented an FPGA implementation of the NEF that successfully performs nonlinear mathematical computations. That work was developed based on a compact digital neural core, which consists of 64 neurons that are instantiated by a single physical neuron using a time-multiplexing approach. We have now scaled this approach up to build a pattern recognition system by combining identical neural cores together. As a proof of concept, we have developed a handwritten digit recognition system using the MNIST database and achieved a recognition rate of 96.55%. The system is implemented on a state-of-the-art FPGA and can process 5.12 million digits per second. The architecture and hardware optimisations presented offer high-speed and resource-efficient means for performing high-speed, neuromorphic, and massively parallel pattern recognition and classification tasks.

  17. Detection of weak gravitational lensing distortions of distant galaxies by cosmic dark matter at large scales

    PubMed

    Wittman; Tyson; Kirkman; Dell'Antonio; Bernstein

    2000-05-11

    Most of the matter in the Universe is not luminous, and can be observed only through its gravitational influence on the appearance of luminous matter. Weak gravitational lensing is a technique that uses the distortions of the images of distant galaxies as a tracer of dark matter: such distortions are induced as the light passes through large-scale distributions of dark matter in the foreground. The patterns of the induced distortions reflect the density of mass along the line of sight and its distribution, and the resulting 'cosmic shear' can be used to distinguish between alternative cosmologies. But previous attempts to measure this effect have been inconclusive. Here we report the detection of cosmic shear on angular scales of up to half a degree using 145,000 galaxies and along three separate lines of sight. We find that the dark matter is distributed in a manner consistent with either an open universe, or a flat universe that is dominated by a cosmological constant. Our results are inconsistent with the standard cold-dark-matter model.

  18. Stuttering, induced fluency, and natural fluency: a hierarchical series of activation likelihood estimation meta-analyses.

    PubMed

    Budde, Kristin S; Barron, Daniel S; Fox, Peter T

    2014-12-01

    Developmental stuttering is a speech disorder most likely due to a heritable form of developmental dysmyelination impairing the function of the speech-motor system. Speech-induced brain-activation patterns in persons who stutter (PWS) are anomalous in various ways; the consistency of these aberrant patterns is a matter of ongoing debate. Here, we present a hierarchical series of coordinate-based meta-analyses addressing this issue. Two tiers of meta-analyses were performed on a 17-paper dataset (202 PWS; 167 fluent controls). Four large-scale (top-tier) meta-analyses were performed, two for each subject group (PWS and controls). These analyses robustly confirmed the regional effects previously postulated as "neural signatures of stuttering" (Brown, Ingham, Ingham, Laird, & Fox, 2005) and extended this designation to additional regions. Two smaller-scale (lower-tier) meta-analyses refined the interpretation of the large-scale analyses: (1) a between-group contrast targeting differences between PWS and controls (stuttering trait); and (2) a within-group contrast (PWS only) of stuttering with induced fluency (stuttering state). Copyright © 2014 Elsevier Inc. All rights reserved.

  19. Comparison of different estimation techniques for biomass concentration in large scale yeast fermentation.

    PubMed

    Hocalar, A; Türker, M; Karakuzu, C; Yüzgeç, U

    2011-04-01

    In this study, previously developed five different state estimation methods are examined and compared for estimation of biomass concentrations at a production scale fed-batch bioprocess. These methods are i. estimation based on kinetic model of overflow metabolism; ii. estimation based on metabolic black-box model; iii. estimation based on observer; iv. estimation based on artificial neural network; v. estimation based on differential evaluation. Biomass concentrations are estimated from available measurements and compared with experimental data obtained from large scale fermentations. The advantages and disadvantages of the presented techniques are discussed with regard to accuracy, reproducibility, number of primary measurements required and adaptation to different working conditions. Among the various techniques, the metabolic black-box method seems to have advantages although the number of measurements required is more than that for the other methods. However, the required extra measurements are based on commonly employed instruments in an industrial environment. This method is used for developing a model based control of fed-batch yeast fermentations. Copyright © 2010 ISA. Published by Elsevier Ltd. All rights reserved.

  20. Symmetry and scale orient Min protein patterns in shaped bacterial sculptures

    NASA Astrophysics Data System (ADS)

    Wu, Fabai; van Schie, Bas G. C.; Keymer, Juan E.; Dekker, Cees

    2015-08-01

    The boundary of a cell defines the shape and scale of its subcellular organization. However, the effects of the cell's spatial boundaries as well as the geometry sensing and scale adaptation of intracellular molecular networks remain largely unexplored. Here, we show that living bacterial cells can be ‘sculpted’ into defined shapes, such as squares and rectangles, which are used to explore the spatial adaptation of Min proteins that oscillate pole-to-pole in rod-shaped Escherichia coli to assist cell division. In a wide geometric parameter space, ranging from 2 × 1 × 1 to 11 × 6 × 1 μm3, Min proteins exhibit versatile oscillation patterns, sustaining rotational, longitudinal, diagonal, stripe and even transversal modes. These patterns are found to directly capture the symmetry and scale of the cell boundary, and the Min concentration gradients scale with the cell size within a characteristic length range of 3-6 μm. Numerical simulations reveal that local microscopic Turing kinetics of Min proteins can yield global symmetry selection, gradient scaling and an adaptive range, when and only when facilitated by the three-dimensional confinement of the cell boundary. These findings cannot be explained by previous geometry-sensing models based on the longest distance, membrane area or curvature, and reveal that spatial boundaries can facilitate simple molecular interactions to result in far more versatile functions than previously understood.

  1. Heterogeneity in homogeneous nucleation from billion-atom molecular dynamics simulation of solidification of pure metal.

    PubMed

    Shibuta, Yasushi; Sakane, Shinji; Miyoshi, Eisuke; Okita, Shin; Takaki, Tomohiro; Ohno, Munekazu

    2017-04-05

    Can completely homogeneous nucleation occur? Large scale molecular dynamics simulations performed on a graphics-processing-unit rich supercomputer can shed light on this long-standing issue. Here, a billion-atom molecular dynamics simulation of homogeneous nucleation from an undercooled iron melt reveals that some satellite-like small grains surrounding previously formed large grains exist in the middle of the nucleation process, which are not distributed uniformly. At the same time, grains with a twin boundary are formed by heterogeneous nucleation from the surface of the previously formed grains. The local heterogeneity in the distribution of grains is caused by the local accumulation of the icosahedral structure in the undercooled melt near the previously formed grains. This insight is mainly attributable to the multi-graphics processing unit parallel computation combined with the rapid progress in high-performance computational environments.Nucleation is a fundamental physical process, however it is a long-standing issue whether completely homogeneous nucleation can occur. Here the authors reveal, via a billion-atom molecular dynamics simulation, that local heterogeneity exists during homogeneous nucleation in an undercooled iron melt.

  2. Characterizing relative humidity with respect to ice in midlatitude cirrus clouds as a function of atmospheric state

    NASA Astrophysics Data System (ADS)

    Dzambo, Andrew M.; Turner, David D.

    2016-10-01

    Midlatitude cirrus cloud macrophysical and microphysical properties have been shown in previous studies to vary seasonally and in various large-scale dynamical regimes, but relative humidity with respect to ice (RHI) within cirrus clouds has not been studied extensively in this context. Using a combination of radiosonde and millimeter-wavelength cloud radar data, we identify 1076 cirrus clouds spanning a 7 year period from 2004 to 2011. These data are separated into five classes using a previously published algorithm that is based largely on synoptic conditions. Using these data and classification scheme, we find that RHI in cirrus clouds varies seasonally. Variations in cirrus cloud RHI exist within the prescribed classifications; however, most of the variations are within the measurement uncertainty. Additionally, with the exception of nonsummer class cirrus, these variations are not statistically significant. We also find that cirrus cloud occurrence is not necessarily correlated with higher observed values of RHI. The structure of RHI in cirrus clouds varies more in thicker clouds, which follows previous studies showing that macrophysical and microphysical variability increases in thicker cirrus clouds.

  3. Large-Scale Urban Localisation with a Pushbroom LIDAR

    DTIC Science & Technology

    2012-10-01

    the sole means of gen- erating full 6-DOF poses from a previously-surveyed workspace. In this approach, Normalised Information Distance is used as the...vehicle to have good knowledge of its position at system- initialization. We now turn to an overview of the use of point-based registration methods for...combination of reference vertices, and provides a convenient representation for the intersection test . Using this parametric representation, the coordinates

  4. Rapid group-, serotype-, and vaccine strain-specific identification of poliovirus isolates by real-time reverse transcription-PCR using degenerate primers and probes containing deoxyinosine residues.

    PubMed

    Kilpatrick, David R; Yang, Chen-Fu; Ching, Karen; Vincent, Annelet; Iber, Jane; Campagnoli, Ray; Mandelbaum, Mark; De, Lina; Yang, Su-Ju; Nix, Allan; Kew, Olen M

    2009-06-01

    We have adapted our previously described poliovirus diagnostic reverse transcription-PCR (RT-PCR) assays to a real-time RT-PCR (rRT-PCR) format. Our highly specific assays and rRT-PCR reagents are designed for use in the WHO Global Polio Laboratory Network for rapid and large-scale identification of poliovirus field isolates.

  5. Mediating Pathways in the Socio-Economic Gradient of Child Development: Evidence from Children 6-42 Months in Bogota

    ERIC Educational Resources Information Center

    Rubio-Codina, Marta; Attanasio, Orazio; Grantham-McGregor, Sally

    2016-01-01

    Research has previously shown a gap of near 0.5 of a standard deviation (SD) in cognition and language development between the top and bottom household wealth quartile in children aged 6-42 months in a large representative sample of low- and middle-income families in Bogota, using the Bayley Scales of Infant and Toddler Development. The gaps in…

  6. Statistical mechanics of neocortical interactions: A scaling paradigm applied to electroencephalography

    NASA Astrophysics Data System (ADS)

    Ingber, Lester

    1991-09-01

    A series of papers has developed a statistical mechanics of neocortical interactions (SMNI), deriving aggregate behavior of experimentally observed columns of neurons from statistical electrical-chemical properties of synaptic interactions. While not useful to yield insights at the single-neuron level, SMNI has demonstrated its capability in describing large-scale properties of short-term memory and electroencephalographic (EEG) systematics. The necessity of including nonlinear and stochastic structures in this development has been stressed. In this paper, a more stringent test is placed on SMNI: The algebraic and numerical algorithms previously developed in this and similar systems are brought to bear to fit large sets of EEG and evoked-potential data being collected to investigate genetic predispositions to alcoholism and to extract brain ``signatures'' of short-term memory. Using the numerical algorithm of very fast simulated reannealing, it is demonstrated that SMNI can indeed fit these data within experimentally observed ranges of its underlying neuronal-synaptic parameters, and the quantitative modeling results are used to examine physical neocortical mechanisms to discriminate high-risk and low-risk populations genetically predisposed to alcoholism. Since this study is a control to span relatively long time epochs, similar to earlier attempts to establish such correlations, this discrimination is inconclusive because of other neuronal activity which can mask such effects. However, the SMNI model is shown to be consistent with EEG data during selective attention tasks and with neocortical mechanisms describing short-term memory previously published using this approach. This paper explicitly identifies similar nonlinear stochastic mechanisms of interaction at the microscopic-neuronal, mesoscopic-columnar, and macroscopic-regional scales of neocortical interactions. These results give strong quantitative support for an accurate intuitive picture, portraying neocortical interactions as having common algebraic or physics mechanisms that scale across quite disparate spatial scales and functional or behavioral phenomena, i.e., describing interactions among neurons, columns of neurons, and regional masses of neurons.

  7. The Link Between Shocks, Turbulence, and Magnetic Reconnection in Collisionless Plasmas

    NASA Technical Reports Server (NTRS)

    Karimabadi, H.; Roytershteyn, V.; Vu, H. X.; Omelchenko, Y. A.; Scudder, J.; Daughton, W.; Dimmock, A.; Nykyri, K.; Wan, M.; Sibeck, D.; hide

    2014-01-01

    Global hybrid (electron fluid, kinetic ions) and fully kinetic simulations of the magnetosphere have been used to show surprising interconnection between shocks, turbulence and magnetic reconnection. In particular collisionless shocks with their reflected ions that can get upstream before retransmission can generate previously unforeseen phenomena in the post shocked flows: (i) formation of reconnecting current sheets and magnetic islands with sizes up to tens of ion inertial length. (ii) Generation of large scale low frequency electromagnetic waves that are compressed and amplified as they cross the shock. These 'wavefronts' maintain their integrity for tens of ion cyclotron times but eventually disrupt and dissipate their energy. (iii) Rippling of the shock front, which can in turn lead to formation of fast collimated jets extending to hundreds of ion inertial lengths downstream of the shock. The jets, which have high dynamical pressure, 'stir' the downstream region, creating large scale disturbances such as vortices, sunward flows, and can trigger flux ropes along the magnetopause. This phenomenology closes the loop between shocks, turbulence and magnetic reconnection in ways previously unrealized. These interconnections appear generic for the collisionless plasmas typical of space, and are expected even at planar shocks, although they will also occur at curved shocks as occur at planets or around ejecta.

  8. Weighted mining of massive collections of [Formula: see text]-values by convex optimization.

    PubMed

    Dobriban, Edgar

    2018-06-01

    Researchers in data-rich disciplines-think of computational genomics and observational cosmology-often wish to mine large bodies of [Formula: see text]-values looking for significant effects, while controlling the false discovery rate or family-wise error rate. Increasingly, researchers also wish to prioritize certain hypotheses, for example, those thought to have larger effect sizes, by upweighting, and to impose constraints on the underlying mining, such as monotonicity along a certain sequence. We introduce Princessp , a principled method for performing weighted multiple testing by constrained convex optimization. Our method elegantly allows one to prioritize certain hypotheses through upweighting and to discount others through downweighting, while constraining the underlying weights involved in the mining process. When the [Formula: see text]-values derive from monotone likelihood ratio families such as the Gaussian means model, the new method allows exact solution of an important optimal weighting problem previously thought to be non-convex and computationally infeasible. Our method scales to massive data set sizes. We illustrate the applications of Princessp on a series of standard genomics data sets and offer comparisons with several previous 'standard' methods. Princessp offers both ease of operation and the ability to scale to extremely large problem sizes. The method is available as open-source software from github.com/dobriban/pvalue_weighting_matlab (accessed 11 October 2017).

  9. Increasing CAD system efficacy for lung texture analysis using a convolutional network

    NASA Astrophysics Data System (ADS)

    Tarando, Sebastian Roberto; Fetita, Catalin; Faccinetto, Alex; Brillet, Pierre-Yves

    2016-03-01

    The infiltrative lung diseases are a class of irreversible, non-neoplastic lung pathologies requiring regular follow-up with CT imaging. Quantifying the evolution of the patient status imposes the development of automated classification tools for lung texture. For the large majority of CAD systems, such classification relies on a two-dimensional analysis of axial CT images. In a previously developed CAD system, we proposed a fully-3D approach exploiting a multi-scale morphological analysis which showed good performance in detecting diseased areas, but with a major drawback consisting of sometimes overestimating the pathological areas and mixing different type of lung patterns. This paper proposes a combination of the existing CAD system with the classification outcome provided by a convolutional network, specifically tuned-up, in order to increase the specificity of the classification and the confidence to diagnosis. The advantage of using a deep learning approach is a better regularization of the classification output (because of a deeper insight into a given pathological class over a large series of samples) where the previous system is extra-sensitive due to the multi-scale response on patient-specific, localized patterns. In a preliminary evaluation, the combined approach was tested on a 10 patient database of various lung pathologies, showing a sharp increase of true detections.

  10. Statistics of Magnetic Reconnection X-Lines in Kinetic Turbulence

    NASA Astrophysics Data System (ADS)

    Haggerty, C. C.; Parashar, T.; Matthaeus, W. H.; Shay, M. A.; Wan, M.; Servidio, S.; Wu, P.

    2016-12-01

    In this work we examine the statistics of magnetic reconnection (x-lines) and their associated reconnection rates in intermittent current sheets generated in turbulent plasmas. Although such statistics have been studied previously for fluid simulations (e.g. [1]), they have not yet been generalized to fully kinetic particle-in-cell (PIC) simulations. A significant problem with PIC simulations, however, is electrostatic fluctuations generated due to numerical particle counting statistics. We find that analyzing gradients of the magnetic vector potential from the raw PIC field data identifies numerous artificial (or non-physical) x-points. Using small Orszag-Tang vortex PIC simulations, we analyze x-line identification and show that these artificial x-lines can be removed using sub-Debye length filtering of the data. We examine how turbulent properties such as the magnetic spectrum and scale dependent kurtosis are affected by particle noise and sub-Debye length filtering. We subsequently apply these analysis methods to a large scale kinetic PIC turbulent simulation. Consistent with previous fluid models, we find a range of normalized reconnection rates as large as ½ but with the bulk of the rates being approximately less than to 0.1. [1] Servidio, S., W. H. Matthaeus, M. A. Shay, P. A. Cassak, and P. Dmitruk (2009), Magnetic reconnection and two-dimensional magnetohydrodynamic turbulence, Phys. Rev. Lett., 102, 115003.

  11. Body frame close coupling wave packet approach to gas phase atom-rigid rotor inelastic collisions

    NASA Technical Reports Server (NTRS)

    Sun, Y.; Judson, R. S.; Kouri, D. J.

    1989-01-01

    The close coupling wave packet (CCWP) method is formulated in a body-fixed representation for atom-rigid rotor inelastic scattering. For J greater than j-max (where J is the total angular momentum and j is the rotational quantum number), the computational cost of propagating the coupled channel wave packets in the body frame is shown to scale approximately as N exp 3/2, where N is the total number of channels. For large numbers of channels, this will be much more efficient than the space frame CCWP method previously developed which scales approximately as N-squared under the same conditions.

  12. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Prinja, A. K.

    The Karhunen-Loeve stochastic spectral expansion of a random binary mixture of immiscible fluids in planar geometry is used to explore asymptotic limits of radiation transport in such mixtures. Under appropriate scalings of mixing parameters - correlation length, volume fraction, and material cross sections - and employing multiple- scale expansion of the angular flux, previously established atomic mix and diffusion limits are reproduced. When applied to highly contrasting material properties in the small cor- relation length limit, the methodology yields a nonstandard reflective medium transport equation that merits further investigation. Finally, a hybrid closure is proposed that produces both small andmore » large correlation length limits of the closure condition for the material averaged equations.« less

  13. Pulsar recoil by large-scale anisotropies in supernova explosions.

    PubMed

    Scheck, L; Plewa, T; Janka, H-Th; Kifonidis, K; Müller, E

    2004-01-09

    Assuming that the neutrino luminosity from the neutron star core is sufficiently high to drive supernova explosions by the neutrino-heating mechanism, we show that low-mode (l=1,2) convection can develop from random seed perturbations behind the shock. A slow onset of the explosion is crucial, requiring the core luminosity to vary slowly with time, in contrast to the burstlike exponential decay assumed in previous work. Gravitational and hydrodynamic forces by the globally asymmetric supernova ejecta were found to accelerate the remnant neutron star on a time scale of more than a second to velocities above 500 km s(-1), in agreement with observed pulsar proper motions.

  14. Numerical experiments with a general circulation model concerning the distribution of ozone in the stratosphere

    NASA Technical Reports Server (NTRS)

    Kurzeja, R. J.; Haggard, K. V.; Grose, W. L.

    1984-01-01

    The distribution of ozone below 60 km altitude has been simulated in two experiments employing a nine-layer quasi-geostrophic spectral model and linear parameterization of ozone photochemistry, the first of which included thermal and orographic forcing of the planetary scale waves, while the second omitted it. The first experiment exhibited a high latitude winter ozone buildup which was due to a Brewer-Dodson circulation forced by large amplitude (planetary scale) waves in the winter lower stratosphere. Photochemistry was also found to be important down to lower altitudes (20 km) in the summer stratosphere than had previously been supposed.

  15. Materialism and life satisfaction: the role of religion.

    PubMed

    Rakrachakarn, Varapa; Moschis, George P; Ong, Fon Sim; Shannon, Randall

    2015-04-01

    This study examines the role of religion and religiosity in the relationship between materialism and life satisfaction. The findings suggests that religion may be a key factor in understanding differences in findings of previous studies regarding the inverserelationship found in the vast majority of previous studies. Based on a large-scale study in Malaysia—a country comprised of several religious subcultures (mainly Muslims, Buddhists, and Hindus), the findings suggest that the influence of religiosity on materialism and life satisfaction is stronger among Malays than among Chinese and Indians, and life satisfaction partially mediates the relationship between religiosity and materialism. The paper discusses implications for theory development and further research.

  16. Digenetic Changes in Macro- to Nano-Scale Porosity in the St. Peter Sandstone:L An (Ultra) Small Angle Neutron Scattering and Backscattered Electron Imagining Analysis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Anovitz, Lawrence; Cole, David; Rother, Gernot

    2013-01-01

    Small- and Ultra-Small Angle Neutron Scattering (SANS and USANS) provide powerful tools for quantitative analysis of porous rocks, yielding bulk statistical information over a wide range of length scales. This study utilized (U)SANS to characterize shallowly buried quartz arenites from the St. Peter Sandstone. Backscattered electron imaging was also used to extend the data to larger scales. These samples contain significant volumes of large-scale porosity, modified by quartz overgrowths, and neutron scattering results show significant sub-micron porosity. While previous scattering data from sandstones suggest scattering is dominated by surface fractal behavior over many orders of magnitude, careful analysis of ourmore » data shows both fractal and pseudo-fractal behavior. The scattering curves are composed of subtle steps, modeled as polydispersed assemblages of pores with log-normal distributions. However, in some samples an additional surface-fractal overprint is present, while in others there is no such structure, and scattering can be explained by summation of non-fractal structures. Combined with our work on other rock-types, these data suggest that microporosity is more prevalent, and may play a much more important role than previously thought in fluid/rock interactions.« less

  17. Fabric Development in a Late-Hercynian Magmatic Strike-Slip Shear Zone in Southern Corsica: Indications of Melt-Supported Large-Scale Deformation Localization

    NASA Astrophysics Data System (ADS)

    Kruhl, J. H.; Vernon, R. H.

    2009-05-01

    The calc-alcaline granitoids of the Hercynian Corsica Batholith show a large-scale magmatic flow pattern, outlined by the alignment of large (mm-cm) euhedral feldspar crystals. The trend of the steep magmatic foliation is generally N-S in the northern part of the island, swings to approximately E-W orientation in the central part of the Batholith and back again to approximately N-S orientation in the southern part. This pattern is intensified by large-scale magmatic layering, mainly kilometer long lenses and layers of mafic and intermediate intrusions into the granitoids. On the macro- to micro-scale, magma mingling and mixing are present, reflecting the complex intrusion history and the compositional variability of the Corsica Batholith on different scales. Around the Golf of Valinco, a steep, sinistral magmatic shear zone is represented by E-W trending magmatic layering in mingled dioritic, tonalitic, and granitic magmas - previously misleadingly interpreted as migmatites - and by a magmatic flow foliation formed by the alignment of platy feldspar crystals, as well as amphibole and biotite. Characteristic magmatic structures include multiple thin layering, boudinage, monoclinic folding, melt-injected micro shear zones, and fragmenting and back- veining of dioritic enclaves. The intensity of grain alignment roughly correlates with the thickness of layers. It is low in thick and short boudins and high in cm-thin and cm-m long layers. The monoclinic folds refold the magmatic layering. Flat faces of amphibole and biotite grains are aligned in the axial planes of the folds. The feldspar crystals are locally recrystallized to a few large polygonal grains (up to 1 mm across), and quartz commonly shows chessboard subgrain patterns. No further indications of solid-state deformation are present. Field observations, as well as pattern quantification on variably oriented rock surfaces, indicate variations of crystal alignment and fabric anisotropy in cm- to more than 100m-wide bands parallel to the E-W oriented layering, and various stages of melt-present fragmentation. These variations are interpreted as variations of flow intensity and possibly strain-rate variation. The observations on the macro- as well as the micro-scale point to repeated injection of mafic to felsic magma and crystallization in the presence of a regional stress field. The resulting km-scale sinistral, sub-horizontal synmagmatic shear zone reflects large-scale movements during late-Hercynian crustal reorganization and represents an excellent example of localization of deformation into magma-enriched parts of the continental crust.

  18. An immersed boundary method for direct and large eddy simulation of stratified flows in complex geometry

    NASA Astrophysics Data System (ADS)

    Rapaka, Narsimha R.; Sarkar, Sutanu

    2016-10-01

    A sharp-interface Immersed Boundary Method (IBM) is developed to simulate density-stratified turbulent flows in complex geometry using a Cartesian grid. The basic numerical scheme corresponds to a central second-order finite difference method, third-order Runge-Kutta integration in time for the advective terms and an alternating direction implicit (ADI) scheme for the viscous and diffusive terms. The solver developed here allows for both direct numerical simulation (DNS) and large eddy simulation (LES) approaches. Methods to enhance the mass conservation and numerical stability of the solver to simulate high Reynolds number flows are discussed. Convergence with second-order accuracy is demonstrated in flow past a cylinder. The solver is validated against past laboratory and numerical results in flow past a sphere, and in channel flow with and without stratification. Since topographically generated internal waves are believed to result in a substantial fraction of turbulent mixing in the ocean, we are motivated to examine oscillating tidal flow over a triangular obstacle to assess the ability of this computational model to represent nonlinear internal waves and turbulence. Results in laboratory-scale (order of few meters) simulations show that the wave energy flux, mean flow properties and turbulent kinetic energy agree well with our previous results obtained using a body-fitted grid (BFG). The deviation of IBM results from BFG results is found to increase with increasing nonlinearity in the wave field that is associated with either increasing steepness of the topography relative to the internal wave propagation angle or with the amplitude of the oscillatory forcing. LES is performed on a large scale ridge, of the order of few kilometers in length, that has the same geometrical shape and same non-dimensional values for the governing flow and environmental parameters as the laboratory-scale topography, but significantly larger Reynolds number. A non-linear drag law is utilized in the large-scale application to parameterize turbulent losses due to bottom friction at high Reynolds number. The large scale problem exhibits qualitatively similar behavior to the laboratory scale problem with some differences: slightly larger intensification of the boundary flow and somewhat higher non-dimensional values for the energy fluxed away by the internal wave field. The phasing of wave breaking and turbulence exhibits little difference between small-scale and large-scale obstacles as long as the important non-dimensional parameters are kept the same. We conclude that IBM is a viable approach to the simulation of internal waves and turbulence in high Reynolds number stratified flows over topography.

  19. MaRaCluster: A Fragment Rarity Metric for Clustering Fragment Spectra in Shotgun Proteomics.

    PubMed

    The, Matthew; Käll, Lukas

    2016-03-04

    Shotgun proteomics experiments generate large amounts of fragment spectra as primary data, normally with high redundancy between and within experiments. Here, we have devised a clustering technique to identify fragment spectra stemming from the same species of peptide. This is a powerful alternative method to traditional search engines for analyzing spectra, specifically useful for larger scale mass spectrometry studies. As an aid in this process, we propose a distance calculation relying on the rarity of experimental fragment peaks, following the intuition that peaks shared by only a few spectra offer more evidence than peaks shared by a large number of spectra. We used this distance calculation and a complete-linkage scheme to cluster data from a recent large-scale mass spectrometry-based study. The clusterings produced by our method have up to 40% more identified peptides for their consensus spectra compared to those produced by the previous state-of-the-art method. We see that our method would advance the construction of spectral libraries as well as serve as a tool for mining large sets of fragment spectra. The source code and Ubuntu binary packages are available at https://github.com/statisticalbiotechnology/maracluster (under an Apache 2.0 license).

  20. The Effect of Large Scale Salinity Gradient on Langmuir Turbulence

    NASA Astrophysics Data System (ADS)

    Fan, Y.; Jarosz, E.; Yu, Z.; Jensen, T.; Sullivan, P. P.; Liang, J.

    2017-12-01

    Langmuir circulation (LC) is believed to be one of the leading order causes of turbulent mixing in the upper ocean. It is important for momentum and heat exchange across the mixed layer (ML) and directly impact the dynamics and thermodynamics in the upper ocean and lower atmosphere including the vertical distributions of chemical, biological, optical, and acoustic properties. Based on Craik and Leibovich (1976) theory, large eddy simulation (LES) models have been developed to simulate LC in the upper ocean, yielding new insights that could not be obtained from field observations and turbulent closure models. Due its high computational cost, LES models are usually limited to small domain sizes and cannot resolve large-scale flows. Furthermore, most LES models used in the LC simulations use periodic boundary conditions in the horizontal direction, which assumes the physical properties (i.e. temperature and salinity) and expected flow patterns in the area of interest are of a periodically repeating nature so that the limited small LES domain is representative for the larger area. Using periodic boundary condition can significantly reduce computational effort in problems, and it is a good assumption for isotropic shear turbulence. However, LC is anisotropic (McWilliams et al 1997) and was observed to be modulated by crosswind tidal currents (Kukulka et al 2011). Using symmetrical domains, idealized LES studies also indicate LC could interact with oceanic fronts (Hamlington et al 2014) and standing internal waves (Chini and Leibovich, 2005). The present study expands our previous LES modeling investigations of Langmuir turbulence to the real ocean conditions with large scale environmental motion that features fresh water inflow into the study region. Large scale gradient forcing is introduced to the NCAR LES model through scale separation analysis. The model is applied to a field observation in the Gulf of Mexico in July, 2016 when the measurement site was impacted by large fresh water inflow due to flooding from the Mississippi river. Model results indicate that the strong salinity gradient can reduce the mean flow in the ML and inhibit the turbulence in the planetary boundary layer. The Langmuir cells are also rotated clockwise by the pressure gradient.

  1. Surface brightness profiles and structural parameters for 53 rich stellar clusters in the Large Magellanic Cloud

    NASA Astrophysics Data System (ADS)

    Mackey, A. D.; Gilmore, G. F.

    2003-01-01

    We have compiled a pseudo-snapshot data set of two-colour observations from the Hubble Space Telescope archive for a sample of 53 rich LMC clusters with ages of 106-1010 yr. We present surface brightness profiles for the entire sample, and derive structural parameters for each cluster, including core radii, and luminosity and mass estimates. Because we expect the results presented here to form the basis for several further projects, we describe in detail the data reduction and surface brightness profile construction processes, and compare our results with those of previous ground-based studies. The surface brightness profiles show a large amount of detail, including irregularities in the profiles of young clusters (such as bumps, dips and sharp shoulders), and evidence for both double clusters and post-core-collapse (PCC) clusters. In particular, we find power-law profiles in the inner regions of several candidate PCC clusters, with slopes of approximately -0.7, but showing considerable variation. We estimate that 20 +/- 7 per cent of the old cluster population of the Large Magellanic Cloud (LMC) has entered PCC evolution, a similar fraction to that for the Galactic globular cluster system. In addition, we examine the profile of R136 in detail and show that it is probably not a PCC cluster. We also observe a trend in core radius with age that has been discovered and discussed in several previous publications by different authors. Our diagram has better resolution, however, and appears to show a bifurcation at several hundred Myr. We argue that this observed relationship reflects true physical evolution in LMC clusters, with some experiencing small-scale core expansion owing to mass loss, and others large-scale expansion owing to some unidentified characteristic or physical process.

  2. Resistivity scaling and electron relaxation times in metallic nanowires

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Moors, Kristof, E-mail: kristof@itf.fys.kuleuven.be; Imec, Kapeldreef 75, B-3001 Leuven; Sorée, Bart

    2014-08-14

    We study the resistivity scaling in nanometer-sized metallic wires due to surface roughness and grain-boundaries, currently the main cause of electron scattering in nanoscaled interconnects. The resistivity has been obtained with the Boltzmann transport equation, adopting the relaxation time approximation of the distribution function and the effective mass approximation for the conducting electrons. The relaxation times are calculated exactly, using Fermi's golden rule, resulting in a correct relaxation time for every sub-band state contributing to the transport. In general, the relaxation time strongly depends on the sub-band state, something that remained unclear with the methods of previous work. The resistivitymore » scaling is obtained for different roughness and grain-boundary properties, showing large differences in scaling behavior and relaxation times. Our model clearly indicates that the resistivity is dominated by grain-boundary scattering, easily surpassing the surface roughness contribution by a factor of 10.« less

  3. A simple scaling approach to produce climate scenarios of local precipitation extremes for the Netherlands

    NASA Astrophysics Data System (ADS)

    Lenderink, Geert; Attema, Jisk

    2015-08-01

    Scenarios of future changes in small scale precipitation extremes for the Netherlands are presented. These scenarios are based on a new approach whereby changes in precipitation extremes are set proportional to the change in water vapor amount near the surface as measured by the 2m dew point temperature. This simple scaling framework allows the integration of information derived from: (i) observations, (ii) a new unprecedentedly large 16 member ensemble of simulations with the regional climate model RACMO2 driven by EC-Earth, and (iii) short term integrations with a non-hydrostatic model Harmonie. Scaling constants are based on subjective weighting (expert judgement) of the three different information sources taking also into account previously published work. In all scenarios local precipitation extremes increase with warming, yet with broad uncertainty ranges expressing incomplete knowledge of how convective clouds and the atmospheric mesoscale circulation will react to climate change.

  4. Corridors cause differential seed predation.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Orrock, John L.; Damschen, Ellen I.

    2005-06-01

    Orrock, John, L., and Ellen I. Damschen. 2005. Corridors cause differential seed predation. Ecol. Apps. 15(3):793-798. Abstract. Corridors that connect disjunct populations are heavily debated in conservation, largely because the effects of corridors have rarely been evaluated by replicated, large-scale studies. Using large-scale experimental landscapes, we found that, in addition to documented positive effects, corridors also have negative impacts on bird-dispersed plants by affecting seed predation, and that overall predation is a function of the seeds primary consumer (rodents or arthropods). Both large-seeded Prunus serotina and small-seeded Rubus allegheniensis experienced greater predation in connected patches. However, P. serotina experienced significantlymore » less seed predation compared to R. allegheniensis in unconnected patches, due to decreased impacts of rodent seed predators on this large-seeded species. Viewed in light of previous evidence that corridors have beneficial impacts by increasing pollination and seed dispersal, this work demonstrates that corridors may have both positive and negative effects for the same plant species at different life stages. Moreover, these effects may differentially affect plant species within the same community: seeds primarily consumed by rodents suffer less predation in unconnected patches. By shifting the impact of rodent and arthropod seed predators, corridors constructed for plant conservation could lead to shifts in the seed bank.« less

  5. Identification of tissue-specific, abiotic stress-responsive gene expression patterns in wine grape (Vitis vinifera L.) based on curation and mining of large-scale EST data sets

    PubMed Central

    2011-01-01

    Background Abiotic stresses, such as water deficit and soil salinity, result in changes in physiology, nutrient use, and vegetative growth in vines, and ultimately, yield and flavor in berries of wine grape, Vitis vinifera L. Large-scale expressed sequence tags (ESTs) were generated, curated, and analyzed to identify major genetic determinants responsible for stress-adaptive responses. Although roots serve as the first site of perception and/or injury for many types of abiotic stress, EST sequencing in root tissues of wine grape exposed to abiotic stresses has been extremely limited to date. To overcome this limitation, large-scale EST sequencing was conducted from root tissues exposed to multiple abiotic stresses. Results A total of 62,236 expressed sequence tags (ESTs) were generated from leaf, berry, and root tissues from vines subjected to abiotic stresses and compared with 32,286 ESTs sequenced from 20 public cDNA libraries. Curation to correct annotation errors, clustering and assembly of the berry and leaf ESTs with currently available V. vinifera full-length transcripts and ESTs yielded a total of 13,278 unique sequences, with 2302 singletons and 10,976 mapped to V. vinifera gene models. Of these, 739 transcripts were found to have significant differential expression in stressed leaves and berries including 250 genes not described previously as being abiotic stress responsive. In a second analysis of 16,452 ESTs from a normalized root cDNA library derived from roots exposed to multiple, short-term, abiotic stresses, 135 genes with root-enriched expression patterns were identified on the basis of their relative EST abundance in roots relative to other tissues. Conclusions The large-scale analysis of relative EST frequency counts among a diverse collection of 23 different cDNA libraries from leaf, berry, and root tissues of wine grape exposed to a variety of abiotic stress conditions revealed distinct, tissue-specific expression patterns, previously unrecognized stress-induced genes, and many novel genes with root-enriched mRNA expression for improving our understanding of root biology and manipulation of rootstock traits in wine grape. mRNA abundance estimates based on EST library-enriched expression patterns showed only modest correlations between microarray and quantitative, real-time reverse transcription-polymerase chain reaction (qRT-PCR) methods highlighting the need for deep-sequencing expression profiling methods. PMID:21592389

  6. Embedding Task-Based Neural Models into a Connectome-Based Model of the Cerebral Cortex

    PubMed Central

    Ulloa, Antonio; Horwitz, Barry

    2016-01-01

    A number of recent efforts have used large-scale, biologically realistic, neural models to help understand the neural basis for the patterns of activity observed in both resting state and task-related functional neural imaging data. An example of the former is The Virtual Brain (TVB) software platform, which allows one to apply large-scale neural modeling in a whole brain framework. TVB provides a set of structural connectomes of the human cerebral cortex, a collection of neural processing units for each connectome node, and various forward models that can convert simulated neural activity into a variety of functional brain imaging signals. In this paper, we demonstrate how to embed a previously or newly constructed task-based large-scale neural model into the TVB platform. We tested our method on a previously constructed large-scale neural model (LSNM) of visual object processing that consisted of interconnected neural populations that represent, primary and secondary visual, inferotemporal, and prefrontal cortex. Some neural elements in the original model were “non-task-specific” (NS) neurons that served as noise generators to “task-specific” neurons that processed shapes during a delayed match-to-sample (DMS) task. We replaced the NS neurons with an anatomical TVB connectome model of the cerebral cortex comprising 998 regions of interest interconnected by white matter fiber tract weights. We embedded our LSNM of visual object processing into corresponding nodes within the TVB connectome. Reciprocal connections between TVB nodes and our task-based modules were included in this framework. We ran visual object processing simulations and showed that the TVB simulator successfully replaced the noise generation originally provided by NS neurons; i.e., the DMS tasks performed with the hybrid LSNM/TVB simulator generated equivalent neural and fMRI activity to that of the original task-based models. Additionally, we found partial agreement between the functional connectivities using the hybrid LSNM/TVB model and the original LSNM. Our framework thus presents a way to embed task-based neural models into the TVB platform, enabling a better comparison between empirical and computational data, which in turn can lead to a better understanding of how interacting neural populations give rise to human cognitive behaviors. PMID:27536235

  7. 2012/13 abnormal cold winter in Japan associated with Large-scale Atmospheric Circulation and Local Sea Surface Temperature over the Sea of Japan

    NASA Astrophysics Data System (ADS)

    Ando, Y.; Ogi, M.; Tachibana, Y.

    2013-12-01

    On Japan, wintertime cold wave has social, economic, psychological and political impacts because of the lack of atomic power stations in the era of post Fukushima world. The colder winter is the more electricity is needed. Wintertime weather of Japan and its prediction has come under the world spotlight. The winter of 2012/13 in Japan was abnormally cold, and such a cold winter has persisted for 3 years. Wintertime climate of Japan is governed by some dominant modes of the large-scale atmospheric circulations. Yasunaka and Hanawa (2008) demonstrated that the two dominant modes - Arctic Oscillation (AO) and Western Pacific (WP) pattern - account for about 65% of the interannual variation of the wintertime mean surface air temperature of Japan. A negative AO brings about cold winter in Japan. In addition, a negative WP also brings about cold winter in Japan. Looking back to the winter of 2012/13, both the negative AO and negative WP continued from October through December. If the previous studies were correct, it would have been extremely very cold from October through December. In fact, in December, in accordance with previous studies, it was colder than normal. Contrary to the expectation, in October and November, it was, however, warmer than normal. This discrepancy signifies that an additional hidden circumstance that heats Japan overwhelms these large-scale atmospheric circulations that cool Japan. In this study, we therefore seek an additional cause of wintertime climate of Japan particularly focusing 2012 as well as the AO and WP. We found that anomalously warm oceanic temperature surrounding Japan overwhelmed influences of the AO or WP. Unlike the inland climate, the island climate can be strongly influenced by surrounding ocean temperature, suggesting that large-scale atmospheric patterns alone do not determine the climate of islands. (a) Time series of a 5-day running mean AO index (blue) as defined by Ogi et al., (2004), who called it the SVNAM index. For reference, the conventional AO index is shown by the gray line. (b) a 5-day running mean WP index, (c) area-averaged Surface Air Temperature anomalies in Japan, (d) Air Temperature anomalies, (e) heat flux anomalies, and (f) Sea Surface Temperature anomalies. The boxed area on the Sea of Japan indicates the area in which the (d)-(f) indexes were calculated.

  8. Multi-time-scale hydroclimate dynamics of a regional watershed and links to large-scale atmospheric circulation: Application to the Seine river catchment, France

    NASA Astrophysics Data System (ADS)

    Massei, N.; Dieppois, B.; Hannah, D. M.; Lavers, D. A.; Fossa, M.; Laignel, B.; Debret, M.

    2017-03-01

    In the present context of global changes, considerable efforts have been deployed by the hydrological scientific community to improve our understanding of the impacts of climate fluctuations on water resources. Both observational and modeling studies have been extensively employed to characterize hydrological changes and trends, assess the impact of climate variability or provide future scenarios of water resources. In the aim of a better understanding of hydrological changes, it is of crucial importance to determine how and to what extent trends and long-term oscillations detectable in hydrological variables are linked to global climate oscillations. In this work, we develop an approach associating correlation between large and local scales, empirical statistical downscaling and wavelet multiresolution decomposition of monthly precipitation and streamflow over the Seine river watershed, and the North Atlantic sea level pressure (SLP) in order to gain additional insights on the atmospheric patterns associated with the regional hydrology. We hypothesized that: (i) atmospheric patterns may change according to the different temporal wavelengths defining the variability of the signals; and (ii) definition of those hydrological/circulation relationships for each temporal wavelength may improve the determination of large-scale predictors of local variations. The results showed that the links between large and local scales were not necessarily constant according to time-scale (i.e. for the different frequencies characterizing the signals), resulting in changing spatial patterns across scales. This was then taken into account by developing an empirical statistical downscaling (ESD) modeling approach, which integrated discrete wavelet multiresolution analysis for reconstructing monthly regional hydrometeorological processes (predictand: precipitation and streamflow on the Seine river catchment) based on a large-scale predictor (SLP over the Euro-Atlantic sector). This approach basically consisted in three steps: 1 - decomposing large-scale climate and hydrological signals (SLP field, precipitation or streamflow) using discrete wavelet multiresolution analysis, 2 - generating a statistical downscaling model per time-scale, 3 - summing up all scale-dependent models in order to obtain a final reconstruction of the predictand. The results obtained revealed a significant improvement of the reconstructions for both precipitation and streamflow when using the multiresolution ESD model instead of basic ESD. In particular, the multiresolution ESD model handled very well the significant changes in variance through time observed in either precipitation or streamflow. For instance, the post-1980 period, which had been characterized by particularly high amplitudes in interannual-to-interdecadal variability associated with alternating flood and extremely low-flow/drought periods (e.g., winter/spring 2001, summer 2003), could not be reconstructed without integrating wavelet multiresolution analysis into the model. In accordance with previous studies, the wavelet components detected in SLP, precipitation and streamflow on interannual to interdecadal time-scales could be interpreted in terms of influence of the Gulf-Stream oceanic front on atmospheric circulation.

  9. Relative dispersion of clustered drifters in a small micro-tidal estuary

    NASA Astrophysics Data System (ADS)

    Suara, Kabir; Chanson, Hubert; Borgas, Michael; Brown, Richard J.

    2017-07-01

    Small tide-dominated estuaries are affected by large scale flow structures which combine with the underlying bed generated smaller scale turbulence to significantly increase the magnitude of horizontal diffusivity. Field estimates of horizontal diffusivity and its associated scales are however rare due to limitations in instrumentation. Data from multiple deployments of low and high resolution clusters of GPS-drifters are used to examine the dynamics of a surface flow in a small micro-tidal estuary through relative dispersion analyses. During the field study, cluster diffusivity, which combines both large- and small-scale processes ranged between, 0.01 and 3.01 m2/s for spreading clusters and, -0.06 and -4.2 m2/s for contracting clusters. Pair-particle dispersion, Dp2, was scale dependent and grew as Dp2 ∼ t1.83 in streamwise and Dp2 ∼ t0.8 in cross-stream directions. At small separation scale, pair-particle (d < 0.5 m) relative diffusivity followed the Richardson's 4/3 power law and became weaker as separation scale increases. Pair-particle diffusivity was described as Kp ∼ d1.01 and Kp ∼ d0.85 in the streamwise and cross-stream directions, respectively for separation scales ranging from 0.1 to 10 m. Two methods were used to identify the mechanism responsible for dispersion within the channel. The results clearly revealed the importance of strain fields (stretching and shearing) in the spreading of particles within a small micro-tidal channel. The work provided input for modelling dispersion of passive particle in shallow micro-tidal estuaries where these were not previously experimentally studied.

  10. Inner-outer interactions in the convective atmospheric boundary layer

    NASA Astrophysics Data System (ADS)

    Salesky, S.

    2017-12-01

    Recently, observational and numerical studies have revealed the existence of so-called large scale motions (LSMs) that populate the logarithmic layer of wall-bounded turbulent shear flows and modulate the amplitude and frequency of turbulence dynamics near the ground. Properties of LSMs are well understood in neutrally stratified flows over smooth and rough walls. However, the implications of previous studies for the convective atmospheric boundary layer (CBL) are not entirely clear, since the morphology of both small-scale and large-scale turbulent structures is known to be strongly affected by buoyancy [e.g. Salesky et al., Bound.-Layer Meteorol. 163:41-68 (2017)]. In the present study, inner-outer interactions in the CBL are investigated using a suite of large eddy simulations spanning neutral to highly convective conditions. Simulation results reveal that, as the atmosphere becomes increasingly unstable, the inclination angle of structures near the ground increases from 12-15° to nearly 90°. Furthermore, the scale separation between the inner and outer peaks in the premultiplied velocity spectra decreases until only a single peak remains (comparable in magnitude to the boundary layer depth). The extent to which the amplitude modulation of surface layer turbulence by outer layer structures changes with increasing instability will be considered, following the decoupling procedure proposed by Mathis et al. [J. Fluid Mech., vol 628, 311-337 (2009)]. Frequency modulation of surface layer turbulence also will be examined, following the wavelet analysis approach of Baars et al. [Exp. Fluids, 56:188, (2015)].

  11. Evolution of wealth in a non-conservative economy driven by local Nash equilibria.

    PubMed

    Degond, Pierre; Liu, Jian-Guo; Ringhofer, Christian

    2014-11-13

    We develop a model for the evolution of wealth in a non-conservative economic environment, extending a theory developed in Degond et al. (2014 J. Stat. Phys. 154, 751-780 (doi:10.1007/s10955-013-0888-4)). The model considers a system of rational agents interacting in a game-theoretical framework. This evolution drives the dynamics of the agents in both wealth and economic configuration variables. The cost function is chosen to represent a risk-averse strategy of each agent. That is, the agent is more likely to interact with the market, the more predictable the market, and therefore the smaller its individual risk. This yields a kinetic equation for an effective single particle agent density with a Nash equilibrium serving as the local thermodynamic equilibrium. We consider a regime of scale separation where the large-scale dynamics is given by a hydrodynamic closure with this local equilibrium. A class of generalized collision invariants is developed to overcome the difficulty of the non-conservative property in the hydrodynamic closure derivation of the large-scale dynamics for the evolution of wealth distribution. The result is a system of gas dynamics-type equations for the density and average wealth of the agents on large scales. We recover the inverse Gamma distribution, which has been previously considered in the literature, as a local equilibrium for particular choices of the cost function. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

  12. Where and why hyporheic exchange is important: Inferences from a parsimonious, physically-based river network model

    NASA Astrophysics Data System (ADS)

    Gomez-Velez, J. D.; Harvey, J. W.

    2014-12-01

    Hyporheic exchange has been hypothesized to have basin-scale consequences; however, predictions throughout river networks are limited by available geomorphic and hydrogeologic data as well as models that can analyze and aggregate hyporheic exchange flows across large spatial scales. We developed a parsimonious but physically-based model of hyporheic flow for application in large river basins: Networks with EXchange and Subsurface Storage (NEXSS). At the core of NEXSS is a characterization of the channel geometry, geomorphic features, and related hydraulic drivers based on scaling equations from the literature and readily accessible information such as river discharge, bankfull width, median grain size, sinuosity, channel slope, and regional groundwater gradients. Multi-scale hyporheic flow is computed based on combining simple but powerful analytical and numerical expressions that have been previously published. We applied NEXSS across a broad range of geomorphic diversity in river reaches and synthetic river networks. NEXSS demonstrates that vertical exchange beneath submerged bedforms dominates hyporheic fluxes and turnover rates along the river corridor. Moreover, the hyporheic zone's potential for biogeochemical transformations is comparable across stream orders, but the abundance of lower-order channels results in a considerably higher cumulative effect for low-order streams. Thus, vertical exchange beneath submerged bedforms has more potential for biogeochemical transformations than lateral exchange beneath banks, although lateral exchange through meanders may be important in large rivers. These results have implications for predicting outcomes of river and basin management practices.

  13. Production of recombinant adeno-associated vectors using two bioreactor configurations at different scales

    PubMed Central

    Negrete, Alejandro; Kotin, Robert M.

    2007-01-01

    The conventional methods for producing recombinant adeno-associated virus (rAAV) rely on transient transfection of adherent mammalian cells. To gain acceptance and achieve current good manufacturing process (cGMP) compliance, clinical grade rAAV production process should have the following qualities: simplicity, consistency, cost effectiveness, and scalability. Currently, the only viable method for producing rAAV in large-scale, e.g.≥1016 particles per production run, utilizes Baculovirus Expression Vectors (BEVs) and insect cells suspension cultures. The previously described rAAV production in 40 L culture using a stirred tank bioreactor requires special conditions for implementation and operation not available in all laboratories. Alternatives to producing rAAV in stirred-tank bioreactors are single-use, disposable bioreactors, e.g. Wave™. The disposable bags are purchased pre-sterilized thereby eliminating the need for end-user sterilization and also avoiding cleaning steps between production runs thus facilitating the production process. In this study, rAAV production in stirred tank and Wave™ bioreactors was compared. The working volumes were 10 L and 40 L for the stirred tank bioreactors and 5 L and 20 L for the Wave™ bioreactors. Comparable yields of rAAV, ~2e+13 particles per liter of cell culture were obtained in all volumes and configurations. These results demonstrate that producing rAAV in large scale using BEVs is reproducible, scalable, and independent of the bioreactor configuration. Keywords: adeno-associated vectors; large-scale production; stirred tank bioreactor; wave bioreactor; gene therapy. PMID:17606302

  14. Planetesimal Formation through the Streaming Instability

    NASA Astrophysics Data System (ADS)

    Yang, Chao-Chin; Johansen, Anders; Schäfer, Urs

    2015-12-01

    The streaming instability is a promising mechanism to circumvent the barriers in direct dust growth and lead to the formation of planetesimals, as demonstrated by many previous studies. In order to resolve the thin layer of solids, however, most of these studies were focused on a local region of a protoplanetary disk with a limited simulation domain. It remains uncertain how the streaming instability is affected by the disk gas on large scales, and models that have sufficient dynamical range to capture both the thin particle layer and the large-scale disk dynamics are required.We hereby systematically push the limits of the computational domain up to more than the gas scale height, and study the particle-gas interaction on large scales in the saturated state of the streaming instability and the initial mass function of the resulting planetesimals. To overcome the numerical challenges posed by this kind of models, we have developed a new technique to simultaneously relieve the stringent time step constraints due to small-sized particles and strong local solid concentrations. Using these models, we demonstrate that the streaming instability can drive multiple radial, filamentary concentrations of solids, implying that planetesimals are born in well separated belt-like structures. We also find that the initial mass function of planetesimals via the streaming instability has a characteristic exponential form, which is robust against computational domain as well as resolution. These findings will help us further constrain the cosmochemical history of the Solar system as well as the planet formation theory in general.

  15. Heat transfer with very high free stream turbulence

    NASA Technical Reports Server (NTRS)

    Moffat, Robert J.; Maciejewski, Paul K.

    1985-01-01

    Stanton numbers as much as 350 percent above the accepted correlations for flat plate turbulent boundary layer heat transfer have been found in experiments on a low velocity air flow with very high turbulence (up to 50 percent). These effects are far larger that have been previously reported and the data do not correlate as well in boundary layer coordinates (Stanton number and Reynolds number) as they do in simpler coordinates: h vs. X. The very high relative turbulence levels were achieved by placing the test plate in different positions in the margin of a large diameter free jet. The large increases may be due to organized structures of large scale which are present in the marginal flowfield around a free jet.

  16. Snow Tweets: Emergency Information Dissemination in a US County During 2014 Winter Storms

    PubMed Central

    Bonnan-White, Jess; Shulman, Jason; Bielecke, Abigail

    2014-01-01

    Introduction: This paper describes how American federal, state, and local organizations created, sourced, and disseminated emergency information via social media in preparation for several winter storms in one county in the state of New Jersey (USA). Methods: Postings submitted to Twitter for three winter storm periods were collected from selected organizations, along with a purposeful sample of select private local users. Storm-related posts were analyzed for stylistic features (hashtags, retweet mentions, embedded URLs). Sharing and re-tweeting patterns were also mapped using NodeXL. Results: Results indicate emergency management entities were active in providing preparedness and response information during the selected winter weather events. A large number of posts, however, did not include unique Twitter features that maximize dissemination and discovery by users. Visual representations of interactions illustrate opportunities for developing stronger relationships among agencies. Discussion: Whereas previous research predominantly focuses on large-scale national or international disaster contexts, the current study instead provides needed analysis in a small-scale context. With practice during localized events like extreme weather, effective information dissemination in large events can be enhanced. PMID:25685629

  17. Snow Tweets: Emergency Information Dissemination in a US County During 2014 Winter Storms.

    PubMed

    Bonnan-White, Jess; Shulman, Jason; Bielecke, Abigail

    2014-12-22

    This paper describes how American federal, state, and local organizations created, sourced, and disseminated emergency information via social media in preparation for several winter storms in one county in the state of New Jersey (USA). Postings submitted to Twitter for three winter storm periods were collected from selected organizations, along with a purposeful sample of select private local users. Storm-related posts were analyzed for stylistic features (hashtags, retweet mentions, embedded URLs). Sharing and re-tweeting patterns were also mapped using NodeXL. RESULTS indicate emergency management entities were active in providing preparedness and response information during the selected winter weather events. A large number of posts, however, did not include unique Twitter features that maximize dissemination and discovery by users. Visual representations of interactions illustrate opportunities for developing stronger relationships among agencies. Whereas previous research predominantly focuses on large-scale national or international disaster contexts, the current study instead provides needed analysis in a small-scale context. With practice during localized events like extreme weather, effective information dissemination in large events can be enhanced.

  18. Computational study of culture conditions and nutrient supply in a hollow membrane sheet bioreactor for large-scale bone tissue engineering.

    PubMed

    Khademi, Ramin; Mohebbi-Kalhori, Davod; Hadjizadeh, Afra

    2014-03-01

    Successful bone tissue culture in a large implant is still a challenge. We have previously developed a porous hollow membrane sheet (HMSh) for tissue engineering applications (Afra Hadjizadeh and Davod Mohebbi-Kalhori, J Biomed. Mater. Res. Part A [2]). This study aims to investigate culture conditions and nutrient supply in a bioreactor made of HMSh. For this purpose, hydrodynamic and mass transport behavior in the newly proposed hollow membrane sheet bioreactor including a lumen region and porous membrane (scaffold) for supporting and feeding cells with a grooved section for accommodating gel-cell matrix was numerically studied. A finite element method was used for solving the governing equations in both homogenous and porous media. Furthermore, the cell resistance and waste production have been included in a 3D mathematical model. The influences of different bioreactor design parameters and the scaffold properties which determine the HMSh bioreactor performance and various operating conditions were discussed in detail. The obtained results illustrated that the novel scaffold can be employed in the large-scale applications in bone tissue engineering.

  19. Experiments with a New, Unique Large-Scale Rig Investigating the Effects of Background System Rotation on Vortex Rings in Water

    NASA Astrophysics Data System (ADS)

    Brend, Mark A.; Verzicco, Roberto

    2005-11-01

    We introduce our unique, new large-scale experimental facility [1] designed for our long-term research program investigating the effects of background system rotation on the stability and the dynamics of vortex rings. The new rig constitutes a large water-filled tank positioned on a rotating turntable and its overall height and diameter are 5.7m and 1.4 m, respectively. First experimental and computational results of our program are summarized. We will show various videos of flow visualizations that illustrate some major, qualitative differences between rings propagating in rotating and non-rotating flows. Some of the investigated characteristics of the vortex rings include their translation velocity, the velocity field inside and surrounding the rings, and, in particular, their stability. We will briefly outline experiments employing the relatively new Ultrasonic-Velocity-Profiler technique (UVP). This technique appears to be particularly suited for some of our measurements and it was, as far as we are aware, not previously used in the context of vortex-ring studies. [1] http://www.eng.warwick.ac.uk/staff/pjt/turntabpics/voriskt.html

  20. Highly multiplexed targeted proteomics using precise control of peptide retention time.

    PubMed

    Gallien, Sebastien; Peterman, Scott; Kiyonami, Reiko; Souady, Jamal; Duriez, Elodie; Schoen, Alan; Domon, Bruno

    2012-04-01

    Large-scale proteomics applications using SRM analysis on triple quadrupole mass spectrometers present new challenges to LC-MS/MS experimental design. Despite the automation of building large-scale LC-SRM methods, the increased numbers of targeted peptides can compromise the balance between sensitivity and selectivity. To facilitate large target numbers, time-scheduled SRM transition acquisition is performed. Previously published results have demonstrated incorporation of a well-characterized set of synthetic peptides enabled chromatographic characterization of the elution profile for most endogenous peptides. We have extended this application of peptide trainer kits to not only build SRM methods but to facilitate real-time elution profile characterization that enables automated adjustment of the scheduled detection windows. Incorporation of dynamic retention time adjustments better facilitate targeted assays lasting several days without the need for constant supervision. This paper provides an overview of how the dynamic retention correction approach identifies and corrects for commonly observed LC variations. This adjustment dramatically improves robustness in targeted discovery experiments as well as routine quantification experiments. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. Detecting Superior Face Recognition Skills in a Large Sample of Young British Adults

    PubMed Central

    Bobak, Anna K.; Pampoulov, Philip; Bate, Sarah

    2016-01-01

    The Cambridge Face Memory Test Long Form (CFMT+) and Cambridge Face Perception Test (CFPT) are typically used to assess the face processing ability of individuals who believe they have superior face recognition skills. Previous large-scale studies have presented norms for the CFPT but not the CFMT+. However, previous research has also highlighted the necessity for establishing country-specific norms for these tests, indicating that norming data is required for both tests using young British adults. The current study addressed this issue in 254 British participants. In addition to providing the first norm for performance on the CFMT+ in any large sample, we also report the first UK specific cut-off for superior face recognition on the CFPT. Further analyses identified a small advantage for females on both tests, and only small associations between objective face recognition skills and self-report measures. A secondary aim of the study was to examine the relationship between trait or social anxiety and face processing ability, and no associations were noted. The implications of these findings for the classification of super-recognizers are discussed. PMID:27713706

  2. Biotic homogenization can decrease landscape-scale forest multifunctionality.

    PubMed

    van der Plas, Fons; Manning, Pete; Soliveres, Santiago; Allan, Eric; Scherer-Lorenzen, Michael; Verheyen, Kris; Wirth, Christian; Zavala, Miguel A; Ampoorter, Evy; Baeten, Lander; Barbaro, Luc; Bauhus, Jürgen; Benavides, Raquel; Benneter, Adam; Bonal, Damien; Bouriaud, Olivier; Bruelheide, Helge; Bussotti, Filippo; Carnol, Monique; Castagneyrol, Bastien; Charbonnier, Yohan; Coomes, David Anthony; Coppi, Andrea; Bastias, Cristina C; Dawud, Seid Muhie; De Wandeler, Hans; Domisch, Timo; Finér, Leena; Gessler, Arthur; Granier, André; Grossiord, Charlotte; Guyot, Virginie; Hättenschwiler, Stephan; Jactel, Hervé; Jaroszewicz, Bogdan; Joly, François-Xavier; Jucker, Tommaso; Koricheva, Julia; Milligan, Harriet; Mueller, Sandra; Muys, Bart; Nguyen, Diem; Pollastrini, Martina; Ratcliffe, Sophia; Raulund-Rasmussen, Karsten; Selvi, Federico; Stenlid, Jan; Valladares, Fernando; Vesterdal, Lars; Zielínski, Dawid; Fischer, Markus

    2016-03-29

    Many experiments have shown that local biodiversity loss impairs the ability of ecosystems to maintain multiple ecosystem functions at high levels (multifunctionality). In contrast, the role of biodiversity in driving ecosystem multifunctionality at landscape scales remains unresolved. We used a comprehensive pan-European dataset, including 16 ecosystem functions measured in 209 forest plots across six European countries, and performed simulations to investigate how local plot-scale richness of tree species (α-diversity) and their turnover between plots (β-diversity) are related to landscape-scale multifunctionality. After accounting for variation in environmental conditions, we found that relationships between α-diversity and landscape-scale multifunctionality varied from positive to negative depending on the multifunctionality metric used. In contrast, when significant, relationships between β-diversity and landscape-scale multifunctionality were always positive, because a high spatial turnover in species composition was closely related to a high spatial turnover in functions that were supported at high levels. Our findings have major implications for forest management and indicate that biotic homogenization can have previously unrecognized and negative consequences for large-scale ecosystem multifunctionality.

  3. Biotic homogenization can decrease landscape-scale forest multifunctionality

    PubMed Central

    van der Plas, Fons; Manning, Pete; Soliveres, Santiago; Allan, Eric; Scherer-Lorenzen, Michael; Verheyen, Kris; Wirth, Christian; Zavala, Miguel A.; Ampoorter, Evy; Baeten, Lander; Barbaro, Luc; Bauhus, Jürgen; Benavides, Raquel; Benneter, Adam; Bonal, Damien; Bouriaud, Olivier; Bruelheide, Helge; Bussotti, Filippo; Carnol, Monique; Castagneyrol, Bastien; Charbonnier, Yohan; Coppi, Andrea; Bastias, Cristina C.; Dawud, Seid Muhie; De Wandeler, Hans; Domisch, Timo; Finér, Leena; Granier, André; Grossiord, Charlotte; Guyot, Virginie; Hättenschwiler, Stephan; Jactel, Hervé; Jaroszewicz, Bogdan; Joly, François-xavier; Jucker, Tommaso; Koricheva, Julia; Milligan, Harriet; Mueller, Sandra; Muys, Bart; Nguyen, Diem; Pollastrini, Martina; Ratcliffe, Sophia; Raulund-Rasmussen, Karsten; Selvi, Federico; Stenlid, Jan; Valladares, Fernando; Vesterdal, Lars; Zielínski, Dawid; Fischer, Markus

    2016-01-01

    Many experiments have shown that local biodiversity loss impairs the ability of ecosystems to maintain multiple ecosystem functions at high levels (multifunctionality). In contrast, the role of biodiversity in driving ecosystem multifunctionality at landscape scales remains unresolved. We used a comprehensive pan-European dataset, including 16 ecosystem functions measured in 209 forest plots across six European countries, and performed simulations to investigate how local plot-scale richness of tree species (α-diversity) and their turnover between plots (β-diversity) are related to landscape-scale multifunctionality. After accounting for variation in environmental conditions, we found that relationships between α-diversity and landscape-scale multifunctionality varied from positive to negative depending on the multifunctionality metric used. In contrast, when significant, relationships between β-diversity and landscape-scale multifunctionality were always positive, because a high spatial turnover in species composition was closely related to a high spatial turnover in functions that were supported at high levels. Our findings have major implications for forest management and indicate that biotic homogenization can have previously unrecognized and negative consequences for large-scale ecosystem multifunctionality. PMID:26979952

  4. Concurrent Spectral and Separation-space Views of Small-scale Anisotropy in Rotating Turbulence

    NASA Astrophysics Data System (ADS)

    Vallefuoco, D.; Godeferd, F. S.; Naso, A.

    2017-12-01

    Rotating turbulence is central in astrophysical, geophysical and industrial flows. A background rotation about a fixed axis introduces significant anisotropy in the turbulent dynamics through both linear and nonlinear mechanisms. The flow regime can be characterized by two independent non-dimensional parameters, e.g. the Reynolds and Rossby numbers or, equivalently, the ratio of the integral scale to the Kolmogorov scale L/η, and the ratio rZ/L, where rZ=√(ɛ/Ω3) is the Zeman scale, ɛ is the mean dissipation and Ω is the rotation rate. rZ is the scale at which the inertial timescale equals the rotation timescale. According to classical dimensional arguments (Zeman 1994), if the Reynolds number is large, scales much larger than rZ are mainly affected by rotation while scales much smaller than rZare dominated by the nonlinear dynamics and are expected to recover isotropy. In this work, we characterize incompressible rotating turbulence scale- and direction-dependent anisotropy through high Reynolds number pseudo-spectral forced DNS. We first focus on energy direction-dependent spectra in Fourier space: we show that a high anisotropy small wavenumber range and a low anisotropy large wavenumber range arise. Importantly, anisotropy arises even at scales much smaller than rZ and no small-scale isotropy is observed in our DNS, in contrast with previous numerical results (Delache et al. 2014, Mininni et al. 2012) but in agreement with experiments (Lamriben et al. 2011). Then, we estimate the value of the threshold wavenumber kT between these two anisotropic ranges for a large number of runs, and show that it corresponds to the scale at which dissipative effects are of the same order as those of rotation. Therefore, in the asymptotic inviscid limit, kT tends to infinity and only the low-wavenumber anisotropic range should persist. In this range anisotropy decreases with wavenumber, which is consistent with the classical Zeman argument. In addition, anisotropy at scales much smaller than rZ can be detected in physical space too, in particular for the third-order two-point vector moment F=<δu2 δu>, where δu is the velocity increment. We find the expected inertial trends for F (Galtier 2009) at scales sufficiently larger than the dissipative scale, while smaller scales exhibit qualitatively opposite anisotropic features.

  5. Removal of two large-scale cosmic microwave background anomalies after subtraction of the integrated Sachs-Wolfe effect

    NASA Astrophysics Data System (ADS)

    Rassat, A.; Starck, J.-L.; Dupé, F.-X.

    2013-09-01

    Context. Although there is currently a debate over the significance of the claimed large-scale anomalies in the cosmic microwave background (CMB), their existence is not totally dismissed. In parallel to the debate over their statistical significance, recent work has also focussed on masks and secondary anisotropies as potential sources of these anomalies. Aims: In this work we investigate simultaneously the impact of the method used to account for masked regions as well as the impact of the integrated Sachs-Wolfe (ISW) effect, which is the large-scale secondary anisotropy most likely to affect the CMB anomalies. In this sense, our work is an update of previous works. Our aim is to identify trends in CMB data from different years and with different mask treatments. Methods: We reconstruct the ISW signal due to 2 Micron All-Sky Survey (2MASS) and NRAO VLA Sky Survey (NVSS) galaxies, effectively reconstructing the low-redshift ISW signal out to z ~ 1. We account for regions of missing data using the sparse inpainting technique. We test sparse inpainting of the CMB, large scale structure and ISW and find that it constitutes a bias-free reconstruction method suitable to study large-scale statistical isotropy and the ISW effect. Results: We focus on three large-scale CMB anomalies: the low quadrupole, the quadrupole/octopole alignment, and the octopole planarity. After sparse inpainting, the low quadrupole becomes more anomalous, whilst the quadrupole/octopole alignment becomes less anomalous. The significance of the low quadrupole is unchanged after subtraction of the ISW effect, while the trend amongst the CMB maps is that both the low quadrupole and the quadrupole/octopole alignment have reduced significance, yet other hypotheses remain possible as well (e.g. exotic physics). Our results also suggest that both of these anomalies may be due to the quadrupole alone. While the octopole planarity significance is reduced after inpainting and after ISW subtraction, however, we do not find that it was very anomalous to start with. In the spirit of participating in reproducible research, we make all codes and resulting products which constitute main results of this paper public here: http://www.cosmostat.org/anomaliesCMB.html

  6. A refined regional modeling approach for the Corn Belt - Experiences and recommendations for large-scale integrated modeling

    NASA Astrophysics Data System (ADS)

    Panagopoulos, Yiannis; Gassman, Philip W.; Jha, Manoj K.; Kling, Catherine L.; Campbell, Todd; Srinivasan, Raghavan; White, Michael; Arnold, Jeffrey G.

    2015-05-01

    Nonpoint source pollution from agriculture is the main source of nitrogen and phosphorus in the stream systems of the Corn Belt region in the Midwestern US. This region is comprised of two large river basins, the intensely row-cropped Upper Mississippi River Basin (UMRB) and Ohio-Tennessee River Basin (OTRB), which are considered the key contributing areas for the Northern Gulf of Mexico hypoxic zone according to the US Environmental Protection Agency. Thus, in this area it is of utmost importance to ensure that intensive agriculture for food, feed and biofuel production can coexist with a healthy water environment. To address these objectives within a river basin management context, an integrated modeling system has been constructed with the hydrologic Soil and Water Assessment Tool (SWAT) model, capable of estimating river basin responses to alternative cropping and/or management strategies. To improve modeling performance compared to previous studies and provide a spatially detailed basis for scenario development, this SWAT Corn Belt application incorporates a greatly refined subwatershed structure based on 12-digit hydrologic units or 'subwatersheds' as defined by the US Geological Service. The model setup, calibration and validation are time-demanding and challenging tasks for these large systems, given the scale intensive data requirements, and the need to ensure the reliability of flow and pollutant load predictions at multiple locations. Thus, the objectives of this study are both to comprehensively describe this large-scale modeling approach, providing estimates of pollution and crop production in the region as well as to present strengths and weaknesses of integrated modeling at such a large scale along with how it can be improved on the basis of the current modeling structure and results. The predictions were based on a semi-automatic hydrologic calibration approach for large-scale and spatially detailed modeling studies, with the use of the Sequential Uncertainty Fitting algorithm (SUFI-2) and the SWAT-CUP interface, followed by a manual water quality calibration on a monthly basis. The refined modeling approach developed in this study led to successful predictions across most parts of the Corn Belt region and can be used for testing pollution mitigation measures and agricultural economic scenarios, providing useful information to policy makers and recommendations on similar efforts at the regional scale.

  7. Large-scale gene-centric analysis identifies novel variants for coronary artery disease.

    PubMed

    2011-09-01

    Coronary artery disease (CAD) has a significant genetic contribution that is incompletely characterized. To complement genome-wide association (GWA) studies, we conducted a large and systematic candidate gene study of CAD susceptibility, including analysis of many uncommon and functional variants. We examined 49,094 genetic variants in ∼2,100 genes of cardiovascular relevance, using a customised gene array in 15,596 CAD cases and 34,992 controls (11,202 cases and 30,733 controls of European descent; 4,394 cases and 4,259 controls of South Asian origin). We attempted to replicate putative novel associations in an additional 17,121 CAD cases and 40,473 controls. Potential mechanisms through which the novel variants could affect CAD risk were explored through association tests with vascular risk factors and gene expression. We confirmed associations of several previously known CAD susceptibility loci (eg, 9p21.3:p<10(-33); LPA:p<10(-19); 1p13.3:p<10(-17)) as well as three recently discovered loci (COL4A1/COL4A2, ZC3HC1, CYP17A1:p<5×10(-7)). However, we found essentially null results for most previously suggested CAD candidate genes. In our replication study of 24 promising common variants, we identified novel associations of variants in or near LIPA, IL5, TRIB1, and ABCG5/ABCG8, with per-allele odds ratios for CAD risk with each of the novel variants ranging from 1.06-1.09. Associations with variants at LIPA, TRIB1, and ABCG5/ABCG8 were supported by gene expression data or effects on lipid levels. Apart from the previously reported variants in LPA, none of the other ∼4,500 low frequency and functional variants showed a strong effect. Associations in South Asians did not differ appreciably from those in Europeans, except for 9p21.3 (per-allele odds ratio: 1.14 versus 1.27 respectively; P for heterogeneity = 0.003). This large-scale gene-centric analysis has identified several novel genes for CAD that relate to diverse biochemical and cellular functions and clarified the literature with regard to many previously suggested genes.

  8. Phylogenomic analysis of a rapid radiation of misfit fishes (Syngnathiformes) using ultraconserved elements.

    PubMed

    Longo, S J; Faircloth, B C; Meyer, A; Westneat, M W; Alfaro, M E; Wainwright, P C

    2017-08-01

    Phylogenetics is undergoing a revolution as large-scale molecular datasets reveal unexpected but repeatable rearrangements of clades that were previously thought to be disparate lineages. One of the most unusual clades of fishes that has been found using large-scale molecular datasets is an expanded Syngnathiformes including traditional long-snouted syngnathiform lineages (Aulostomidae, Centriscidae, Fistulariidae, Solenostomidae, Syngnathidae), as well as a diverse set of largely benthic-associated fishes (Callionymoidei, Dactylopteridae, Mullidae, Pegasidae) that were previously dispersed across three orders. The monophyly of this surprising clade of fishes has been upheld by recent studies utilizing both nuclear and mitogenomic data, but the relationships among major lineages within Syngnathiformes remain ambiguous; previous analyses have inconsistent topologies and are plagued by low support at deep divergences between the major lineages. In this study, we use a dataset of ultraconserved elements (UCEs) to conduct the first phylogenomic study of Syngnathiformes. UCEs have been effective markers for resolving deep phylogenetic relationships in fishes and, combined with increased taxon sampling, we expected UCEs to resolve problematic syngnathiform relationships. Overall, UCEs were effective at resolving relationships within Syngnathiformes at a range of evolutionary timescales. We find consistent support for the monophyly of traditional long-snouted syngnathiform lineages (Aulostomidae, Centriscidae, Fistulariidae, Solenostomidae, Syngnathidae), which better agrees with morphological hypotheses than previously published topologies from molecular data. This result was supported by all Bayesian and maximum likelihood analyses, was robust to differences in matrix completeness and potential sources of bias, and was highly supported in coalescent-based analyses in ASTRAL when matrices were filtered to contain the most phylogenetically informative loci. While Bayesian and maximum likelihood analyses found support for a benthic-associated clade (Callionymidae, Dactylopteridae, Mullidae, and Pegasidae) as sister to the long-snouted clade, this result was not replicated in the ASTRAL analyses. The base of our phylogeny is characterized by short internodes separating major syngnathiform lineages and is consistent with the hypothesis of an ancient rapid radiation at the base of Syngnathiformes. Syngnathiformes therefore present an exciting opportunity to study patterns of morphological variation and functional innovation arising from rapid but ancient radiation. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. The morphometric and stratigraphic framework for estimates of debris flow incidence in the North Cascades foothills, Washington State, USA

    NASA Astrophysics Data System (ADS)

    Kovanen, Dori J.; Slaymaker, Olav

    2008-07-01

    Active debris flow fans in the North Cascade Foothills of Washington State constitute a natural hazard of importance to land managers, private property owners and personal security. In the absence of measurements of the sediment fluxes involved in debris flow events, a morphological-evolutionary systems approach, emphasizing stratigraphy, dating, fan morphology and debris flow basin morphometry, was used. Using the stratigraphic framework and 47 radiocarbon dates, frequency of occurrence and relative magnitudes of debris flow events have been estimated for three spatial scales of debris flow systems: the within-fan site scale (84 observations); the fan meso-scale (six observations) and the lumped fan, regional or macro-scale (one fan average and adjacent lake sediments). In order to characterize the morphometric framework, plots of basin area v. fan area, basin area v. fan gradient and the Melton ruggedness number v. fan gradient for the 12 debris flow basins were compared with those documented for semi-arid and paraglacial fans. Basin area to fan area ratios were generally consistent with the estimated level of debris flow activity during the Holocene as reported below. Terrain analysis of three of the most active debris flow basins revealed the variety of modes of slope failure and sediment production in the region. Micro-scale debris flow event systems indicated a range of recurrence intervals for large debris flows from 106-3645 years. The spatial variation of these rates across the fans was generally consistent with previously mapped hazard zones. At the fan meso-scale, the range of recurrence intervals for large debris flows was 273-1566 years and at the regional scale, the estimated recurrence interval of large debris flows was 874 years (with undetermined error bands) during the past 7290 years. Dated lake sediments from the adjacent Lake Whatcom gave recurrence intervals for large sediment producing events ranging from 481-557 years over the past 3900 years and clearly discernible sedimentation events in the lacustrine sediments had a recurrence interval of 67-78 years over that same period.

  10. Resolution, Scales and Predictability: Is High Resolution Detrimental To Predictability At Extended Forecast Times?

    NASA Astrophysics Data System (ADS)

    Mesinger, F.

    The traditional views hold that high-resolution limited area models (LAMs) down- scale large-scale lateral boundary information, and that predictability of small scales is short. Inspection of various rms fits/errors has contributed to these views. It would follow that the skill of LAMs should visibly deteriorate compared to that of their driver models at more extended forecast times. The limited area Eta Model at NCEP has an additional handicap of being driven by LBCs of the previous Avn global model run, at 0000 and 1200 UTC estimated to amount to about an 8 h loss in accuracy. This should make its relative skill compared to that of the Avn deteriorate even faster. These views are challenged by various Eta results including rms fits to raobs out to 84 h. It is argued that it is the largest scales that contribute the most to the skill of the Eta relative to that of the Avn.

  11. A dual-scale metal nanowire network transparent conductor for highly efficient and flexible organic light emitting diodes.

    PubMed

    Lee, Jinhwan; An, Kunsik; Won, Phillip; Ka, Yoonseok; Hwang, Hyejin; Moon, Hyunjin; Kwon, Yongwon; Hong, Sukjoon; Kim, Changsoon; Lee, Changhee; Ko, Seung Hwan

    2017-02-02

    Although solution processed metal nanowire (NW) percolation networks are a strong candidate to replace commercial indium tin oxide, their performance is limited in thin film device applications due to reduced effective electrical areas arising from the dimple structure and percolative voids that single size metal NW percolation networks inevitably possess. Here, we present a transparent electrode based on a dual-scale silver nanowire (AgNW) percolation network embedded in a flexible substrate to demonstrate a significant enhancement in the effective electrical area by filling the large percolative voids present in a long/thick AgNW network with short/thin AgNWs. As a proof of concept, the performance enhancement of a flexible phosphorescent OLED is demonstrated with the dual-scale AgNW percolation network compared to the previous mono-scale AgNWs. Moreover, we report that mechanical and oxidative robustness, which are critical for flexible OLEDs, are greatly increased by embedding the dual-scale AgNW network in a resin layer.

  12. An examination of the validity of the Academic Motivation Scale with a United States business student sample.

    PubMed

    Smith, Kenneth J; Davy, Jeanette A; Rosenberg, Donald L

    2010-04-01

    This study examined alternative seven-, five-, and three-factor structures for the Academic Motivation Scale, with data from a large convenience sample of 2,078 students matriculating in various business courses at three AACSB-accredited regional comprehensive universities. In addition, the invariance of the scale's factor structure between male and female students and between undergraduate and Master's of Business Administration students was investigated. Finally, the internal consistency of the items loading on each of the seven AMS subscales was assessed as well as whether the correlations among the subscales supported a continuum of self-determination. Results for the full sample as well as the targeted subpopulations supported the seven factor configuration of the scale with adequate model fit achieved for all but the MBA student group. The data also generated acceptable internal consistency statistics for all of the subscales. However, in line with a number of previous studies, the correlations between subscales failed to fully support the scale's simplex structure as proposed by self-determination theory.

  13. From symptoms to social functioning: differential effects of antidepressant therapy.

    PubMed

    Kasper, S

    1999-05-01

    Significant impairments in social functioning frequently occur simultaneously with depressive symptoms. The implications of such impairments extend beyond the depressed individual to their family, friends and society at large. Classical rating scales such as the Hamilton rating scale for depression primarily assess the core symptoms of depression. A range of rating scales are available, both self-reporting and administered by clinician; however, many have been criticised for their unspecified conceptual background and for being complex and time-consuming. While antidepressants in general appear to improve social functioning, no clear advantage for any single class of agent has been reported. Recently, a new self-report rating scale, the Social Adaptation Self-evaluation Scale, has been developed and used to compare the novel selective noradrenaline reuptake inhibitor, reboxetine, with the selective serotonin re-uptake inhibitor, fluoxetine. The noradrenergic agent, reboxetine, was shown to be significantly more effective in improving social functioning than the serotonergic agent, fluoxetine. These findings are consistent with previous observations that noradrenaline may preferentially improve vigilance, motivation and self-perception.

  14. The presence of magical thinking in obsessive compulsive disorder.

    PubMed

    Einstein, Danielle A; Menzies, Ross G

    2004-05-01

    Two research groups have raised the possibility that magical ideation may be a fundamental feature of obsessive-compulsive disorder. It has been proposed to underlie thought action fusion and superstitious beliefs. In this study, the Magical Ideation scale, the Lucky Behaviours and Lucky Beliefs scales, the Thought Action Fusion-Revised scale, the Padua Inventory, and the Obsessive Compulsive Inventory-Short Version were completed by 60 obsessive compulsive patients at a hospital clinic. Of all the measures, the Magical Ideation (MI) scale was found to be the most strongly related to obsessive compulsive symptoms. Large and significant relationships between MI scores and the measures of OCD were obtained even when alternative constructs (Lucky Behaviours, Lucky Beliefs, Thought Action Fusion-Revised scales) were held constant. No other variable remained significantly related to the Obsessive Compulsive Inventory-Short Version when magical ideation scores were held constant. The findings suggest that a general magical thinking tendency may underpin previous observed links between superstitiousness, thought action fusion and OCD severity.

  15. Spatial adaptive sampling in multiscale simulation

    NASA Astrophysics Data System (ADS)

    Rouet-Leduc, Bertrand; Barros, Kipton; Cieren, Emmanuel; Elango, Venmugil; Junghans, Christoph; Lookman, Turab; Mohd-Yusof, Jamaludin; Pavel, Robert S.; Rivera, Axel Y.; Roehm, Dominic; McPherson, Allen L.; Germann, Timothy C.

    2014-07-01

    In a common approach to multiscale simulation, an incomplete set of macroscale equations must be supplemented with constitutive data provided by fine-scale simulation. Collecting statistics from these fine-scale simulations is typically the overwhelming computational cost. We reduce this cost by interpolating the results of fine-scale simulation over the spatial domain of the macro-solver. Unlike previous adaptive sampling strategies, we do not interpolate on the potentially very high dimensional space of inputs to the fine-scale simulation. Our approach is local in space and time, avoids the need for a central database, and is designed to parallelize well on large computer clusters. To demonstrate our method, we simulate one-dimensional elastodynamic shock propagation using the Heterogeneous Multiscale Method (HMM); we find that spatial adaptive sampling requires only ≈ 50 ×N0.14 fine-scale simulations to reconstruct the stress field at all N grid points. Related multiscale approaches, such as Equation Free methods, may also benefit from spatial adaptive sampling.

  16. Large-scale production and study of a synthetic G protein-coupled receptor: Human olfactory receptor 17-4

    PubMed Central

    Cook, Brian L.; Steuerwald, Dirk; Kaiser, Liselotte; Graveland-Bikker, Johanna; Vanberghem, Melanie; Berke, Allison P.; Herlihy, Kara; Pick, Horst; Vogel, Horst; Zhang, Shuguang

    2009-01-01

    Although understanding of the olfactory system has progressed at the level of downstream receptor signaling and the wiring of olfactory neurons, the system remains poorly understood at the molecular level of the receptors and their interaction with and recognition of odorant ligands. The structure and functional mechanisms of these receptors still remain a tantalizing enigma, because numerous previous attempts at the large-scale production of functional olfactory receptors (ORs) have not been successful to date. To investigate the elusive biochemistry and molecular mechanisms of olfaction, we have developed a mammalian expression system for the large-scale production and purification of a functional OR protein in milligram quantities. Here, we report the study of human OR17-4 (hOR17-4) purified from a HEK293S tetracycline-inducible system. Scale-up of production yield was achieved through suspension culture in a bioreactor, which enabled the preparation of >10 mg of monomeric hOR17-4 receptor after immunoaffinity and size exclusion chromatography, with expression yields reaching 3 mg/L of culture medium. Several key post-translational modifications were identified using MS, and CD spectroscopy showed the receptor to be ≈50% α-helix, similar to other recently determined G protein-coupled receptor structures. Detergent-solubilized hOR17-4 specifically bound its known activating odorants lilial and floralozone in vitro, as measured by surface plasmon resonance. The hOR17-4 also recognized specific odorants in heterologous cells as determined by calcium ion mobilization. Our system is feasible for the production of large quantities of OR necessary for structural and functional analyses and research into OR biosensor devices. PMID:19581598

  17. Large-scale production and study of a synthetic G protein-coupled receptor: human olfactory receptor 17-4.

    PubMed

    Cook, Brian L; Steuerwald, Dirk; Kaiser, Liselotte; Graveland-Bikker, Johanna; Vanberghem, Melanie; Berke, Allison P; Herlihy, Kara; Pick, Horst; Vogel, Horst; Zhang, Shuguang

    2009-07-21

    Although understanding of the olfactory system has progressed at the level of downstream receptor signaling and the wiring of olfactory neurons, the system remains poorly understood at the molecular level of the receptors and their interaction with and recognition of odorant ligands. The structure and functional mechanisms of these receptors still remain a tantalizing enigma, because numerous previous attempts at the large-scale production of functional olfactory receptors (ORs) have not been successful to date. To investigate the elusive biochemistry and molecular mechanisms of olfaction, we have developed a mammalian expression system for the large-scale production and purification of a functional OR protein in milligram quantities. Here, we report the study of human OR17-4 (hOR17-4) purified from a HEK293S tetracycline-inducible system. Scale-up of production yield was achieved through suspension culture in a bioreactor, which enabled the preparation of >10 mg of monomeric hOR17-4 receptor after immunoaffinity and size exclusion chromatography, with expression yields reaching 3 mg/L of culture medium. Several key post-translational modifications were identified using MS, and CD spectroscopy showed the receptor to be approximately 50% alpha-helix, similar to other recently determined G protein-coupled receptor structures. Detergent-solubilized hOR17-4 specifically bound its known activating odorants lilial and floralozone in vitro, as measured by surface plasmon resonance. The hOR17-4 also recognized specific odorants in heterologous cells as determined by calcium ion mobilization. Our system is feasible for the production of large quantities of OR necessary for structural and functional analyses and research into OR biosensor devices.

  18. A k-space method for large-scale models of wave propagation in tissue.

    PubMed

    Mast, T D; Souriau, L P; Liu, D L; Tabei, M; Nachman, A I; Waag, R C

    2001-03-01

    Large-scale simulation of ultrasonic pulse propagation in inhomogeneous tissue is important for the study of ultrasound-tissue interaction as well as for development of new imaging methods. Typical scales of interest span hundreds of wavelengths; most current two-dimensional methods, such as finite-difference and finite-element methods, are unable to compute propagation on this scale with the efficiency needed for imaging studies. Furthermore, for most available methods of simulating ultrasonic propagation, large-scale, three-dimensional computations of ultrasonic scattering are infeasible. Some of these difficulties have been overcome by previous pseudospectral and k-space methods, which allow substantial portions of the necessary computations to be executed using fast Fourier transforms. This paper presents a simplified derivation of the k-space method for a medium of variable sound speed and density; the derivation clearly shows the relationship of this k-space method to both past k-space methods and pseudospectral methods. In the present method, the spatial differential equations are solved by a simple Fourier transform method, and temporal iteration is performed using a k-t space propagator. The temporal iteration procedure is shown to be exact for homogeneous media, unconditionally stable for "slow" (c(x) < or = c0) media, and highly accurate for general weakly scattering media. The applicability of the k-space method to large-scale soft tissue modeling is shown by simulating two-dimensional propagation of an incident plane wave through several tissue-mimicking cylinders as well as a model chest wall cross section. A three-dimensional implementation of the k-space method is also employed for the example problem of propagation through a tissue-mimicking sphere. Numerical results indicate that the k-space method is accurate for large-scale soft tissue computations with much greater efficiency than that of an analogous leapfrog pseudospectral method or a 2-4 finite difference time-domain method. However, numerical results also indicate that the k-space method is less accurate than the finite-difference method for a high contrast scatterer with bone-like properties, although qualitative results can still be obtained by the k-space method with high efficiency. Possible extensions to the method, including representation of absorption effects, absorbing boundary conditions, elastic-wave propagation, and acoustic nonlinearity, are discussed.

  19. From Fibrils to Toughness: Multi-Scale Mechanics of Fibrillating Interfaces in Stretchable Electronics

    PubMed Central

    van der Sluis, Olaf; Vossen, Bart; Geers, Marc

    2018-01-01

    Metal-elastomer interfacial systems, often encountered in stretchable electronics, demonstrate remarkably high interface fracture toughness values. Evidently, a large gap exists between the rather small adhesion energy levels at the microscopic scale (‘intrinsic adhesion’) and the large measured macroscopic work-of-separation. This energy gap is closed here by unravelling the underlying dissipative mechanisms through a systematic numerical/experimental multi-scale approach. This self-containing contribution collects and reviews previously published results and addresses the remaining open questions by providing new and independent results obtained from an alternative experimental set-up. In particular, the experimental studies on Cu-PDMS (Poly(dimethylsiloxane)) samples conclusively reveal the essential role of fibrillation mechanisms at the micro-meter scale during the metal-elastomer delamination process. The micro-scale numerical analyses on single and multiple fibrils show that the dynamic release of the stored elastic energy by multiple fibril fracture, including the interaction with the adjacent deforming bulk PDMS and its highly nonlinear behaviour, provide a mechanistic understanding of the high work-of-separation. An experimentally validated quantitative relation between the macroscopic work-of-separation and peel front height is established from the simulation results. Finally, it is shown that a micro-mechanically motivated shape of the traction-separation law in cohesive zone models is essential to describe the delamination process in fibrillating metal-elastomer systems in a physically meaningful way. PMID:29393908

  20. Atomic orbital-based SOS-MP2 with tensor hypercontraction. II. Local tensor hypercontraction

    NASA Astrophysics Data System (ADS)

    Song, Chenchen; Martínez, Todd J.

    2017-01-01

    In the first paper of the series [Paper I, C. Song and T. J. Martinez, J. Chem. Phys. 144, 174111 (2016)], we showed how tensor-hypercontracted (THC) SOS-MP2 could be accelerated by exploiting sparsity in the atomic orbitals and using graphical processing units (GPUs). This reduced the formal scaling of the SOS-MP2 energy calculation to cubic with respect to system size. The computational bottleneck then becomes the THC metric matrix inversion, which scales cubically with a large prefactor. In this work, the local THC approximation is proposed to reduce the computational cost of inverting the THC metric matrix to linear scaling with respect to molecular size. By doing so, we have removed the primary bottleneck to THC-SOS-MP2 calculations on large molecules with O(1000) atoms. The errors introduced by the local THC approximation are less than 0.6 kcal/mol for molecules with up to 200 atoms and 3300 basis functions. Together with the graphical processing unit techniques and locality-exploiting approaches introduced in previous work, the scaled opposite spin MP2 (SOS-MP2) calculations exhibit O(N2.5) scaling in practice up to 10 000 basis functions. The new algorithms make it feasible to carry out SOS-MP2 calculations on small proteins like ubiquitin (1231 atoms/10 294 atomic basis functions) on a single node in less than a day.

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