Establishment of QC/QA procedures for open-graded mixes : final report.

DOT National Transportation Integrated Search

1998-09-01

The State of Oregon has employed the use of porous concrete surfaces (E- and F-mixes) since the 1970s. The use of porous mixes has increased substantially in the past five years. Previously, no work had been done to evaluate whether the quality contr...

High efficiency IR supercontinuum generation and applications: a review

NASA Astrophysics Data System (ADS)

Yin, Shizhuo; Ruffin, Paul; Brantley, Christina; Edwards, Eugene; Cheng, Jiping; Yao, Jimmy; Luo, Claire

2011-10-01

In this paper, we have reviewed our recent works on IR supercontinuum generation (SCG) and its applications. First, we provide a brief review on the physical mechanism of the supercontinuum generation and our previous works in this field. Second, the transmission characteristics of a new type of IR fibers is presented. Furthermore, the SCG generation in this new type of optical fiber is experimentally demonstrated. Finally, the suggestion for the future effort is discussed.

Psychosocial working conditions and weight gain among employees.

PubMed

Lallukka, T; Laaksonen, M; Martikainen, P; Sarlio-Lähteenkorva, S; Lahelma, E

2005-08-01

To study the associations between psychosocial working conditions and weight gain. Data from postal questionnaires (response rate 67%) sent to 40- to 60-y-old women (n=7093) and men (n=1799) employed by the City of Helsinki in 2000-2002 were analysed. Weight gain during the previous 12 months was the outcome variable in logistic regression analyses. Independent variables included Karasek's job demands and job control, work fatigue, working overtime, work-related mental strain, social support and the work-home interface. The final models were adjusted for age, education, marital status, physical strain and body mass index. In the previous 12 months, 25% of women and 19% of men reported weight gain. Work fatigue and working overtime were associated with weight gain in both sexes. Women who were dissatisfied with combining paid work and family life were more likely to have gained weight. Men with low job demands were less likely to have gained weight. All of these associations were independent of each other. Few work-related factors were associated with weight gain. However, our study suggests that work fatigue and working overtime are potential risk factors for weight gain. These findings need to be confirmed in prospective studies.

Understanding young stars - A history

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stahler, S.W.

1988-12-01

The history of pre-main-sequence theory is briefly reviewed. The paper of Henyey et al. (1955) is seen as an important transitional work, one which abandoned previous simplifying assumptions yet failed to incorporate newer insights into the surface structure of late-type stars. The subsequent work of Hayashi and his contemporaries is outlined, with an emphasis on the underlying physical principles. Finally, the recent impact of protostar theory is discussed, and speculations are offered on future developments. 56 references.

Common Elements of Capstone Projects in the World's Top-Ranked Engineering Universities

ERIC Educational Resources Information Center

Ward, Thomas A.

2013-01-01

"Capstone" is a metaphor used to describe a final achievement that builds upon previous works and encapsulates them. Capstone projects are included in engineering curricula to integrate multi-disciplinary subjects and teach professional skills that are difficult to impart in a traditional lectured course. Since these projects serve to…

Research in Chinese-English Machine Translation. Final Report.

ERIC Educational Resources Information Center

Wang, William S-Y.; And Others

This report documents results of a two-year effort toward the study and investigation of the design of a prototype system for Chinese-English machine translation in the general area of physics. Previous work in Chinese-English machine translation is reviewed. Grammatical considerations in machine translation are discussed and detailed aspects of…

Are We Teaching the IS 2009 Model Curriculum?

ERIC Educational Resources Information Center

Apigian, Charles H.; Gambill, Stanley E.

2010-01-01

This article presents the results of research that gathered data about undergraduate information systems curricula and compared it to previous studies and the IS 2009 working model curriculum which is now named IS 2010 Model Curriculum after final approval. Data was collected from the websites of 240 colleges and universities identified as having…

Online Catalog Documentation Task Force: Onscreen Documentation Subgroup. Final Report.

ERIC Educational Resources Information Center

Campbell, John; And Others

This report describes the work of the Onscreen Documentation Subgroup in revising screens for GALIN, the University of Georgia (UGA) Libraries new online system. The responsibilities of the Subgroup were to revise screens from the previous online catalog and to create basic help screens, primarily for the command searching mode. Responsibilities…

Molecular Mechanisms Underlying Individual Differences in Response to Stress in a Previously Validated Animal Model of PTSD

DTIC Science & Technology

2012-04-01

CONTRACTING ORGANIZATION: Bronx Veterans Medical Research Foundation, Inc... Bronx , NY 10468-3904 REPORT DATE: April 2012 TYPE OF REPORT: Final PREPARED FOR: U.S. Army...WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER Bronx Veterans Medical Research

Incidental and Context-Responsive Activation of Structure- and Function-Based Action Features during Object Identification

ERIC Educational Resources Information Center

Lee, Chia-lin; Middleton, Erica; Mirman, Daniel; Kalenine, Solene; Buxbaum, Laurel J.

2013-01-01

Previous studies suggest that action representations are activated during object processing, even when task-irrelevant. In addition, there is evidence that lexical-semantic context may affect such activation during object processing. Finally, prior work from our laboratory and others indicates that function-based ("use") and structure-based…

A simulation analysis to characterize the dynamics of vaccinating behaviour on contact networks.

PubMed

Perisic, Ana; Bauch, Chris T

2009-05-28

Human behavior influences infectious disease transmission, and numerous "prevalence-behavior" models have analyzed this interplay. These previous analyses assumed homogeneously mixing populations without spatial or social structure. However, spatial and social heterogeneity are known to significantly impact transmission dynamics and are particularly relevant for certain diseases. Previous work has demonstrated that social contact structure can change the individual incentive to vaccinate, thus enabling eradication of a disease under a voluntary vaccination policy when the corresponding homogeneous mixing model predicts that eradication is impossible due to free rider effects. Here, we extend this work and characterize the range of possible behavior-prevalence dynamics on a network. We simulate transmission of a vaccine-preventable infection through a random, static contact network. Individuals choose whether or not to vaccinate on any given day according to perceived risks of vaccination and infection. We find three possible outcomes for behavior-prevalence dynamics on this type of network: small final number vaccinated and final epidemic size (due to rapid control through voluntary ring vaccination); large final number vaccinated and significant final epidemic size (due to imperfect voluntary ring vaccination), and little or no vaccination and large final epidemic size (corresponding to little or no voluntary ring vaccination). We also show that the social contact structure enables eradication under a broad range of assumptions, except when vaccine risk is sufficiently high, the disease risk is sufficiently low, or individuals vaccinate too late for the vaccine to be effective. For populations where infection can spread only through social contact network, relatively small differences in parameter values relating to perceived risk or vaccination behavior at the individual level can translate into large differences in population-level outcomes such as final size and final number vaccinated. The qualitative outcome of rational, self interested behaviour under a voluntary vaccination policy can vary substantially depending on interactions between social contact structure, perceived vaccine and disease risks, and the way that individual vaccination decision-making is modelled.

A simulation analysis to characterize the dynamics of vaccinating behaviour on contact networks

PubMed Central

2009-01-01

Background Human behavior influences infectious disease transmission, and numerous "prevalence-behavior" models have analyzed this interplay. These previous analyses assumed homogeneously mixing populations without spatial or social structure. However, spatial and social heterogeneity are known to significantly impact transmission dynamics and are particularly relevant for certain diseases. Previous work has demonstrated that social contact structure can change the individual incentive to vaccinate, thus enabling eradication of a disease under a voluntary vaccination policy when the corresponding homogeneous mixing model predicts that eradication is impossible due to free rider effects. Here, we extend this work and characterize the range of possible behavior-prevalence dynamics on a network. Methods We simulate transmission of a vaccine-prevetable infection through a random, static contact network. Individuals choose whether or not to vaccinate on any given day according to perceived risks of vaccination and infection. Results We find three possible outcomes for behavior-prevalence dynamics on this type of network: small final number vaccinated and final epidemic size (due to rapid control through voluntary ring vaccination); large final number vaccinated and significant final epidemic size (due to imperfect voluntary ring vaccination), and little or no vaccination and large final epidemic size (corresponding to little or no voluntary ring vaccination). We also show that the social contact structure enables eradication under a broad range of assumptions, except when vaccine risk is sufficiently high, the disease risk is sufficiently low, or individuals vaccinate too late for the vaccine to be effective. Conclusion For populations where infection can spread only through social contact network, relatively small differences in parameter values relating to perceived risk or vaccination behavior at the individual level can translate into large differences in population-level outcomes such as final size and final number vaccinated. The qualitative outcome of rational, self interested behaviour under a voluntary vaccination policy can vary substantially depending on interactions between social contact structure, perceived vaccine and disease risks, and the way that individual vaccination decision-making is modelled. PMID:19476616

Previous Employment and Job Satisfaction Conditions: The Case of Regional Administration

NASA Astrophysics Data System (ADS)

Amalia, Myronaki; Nikolaos, Antonakas

2009-08-01

In the present work we study the different dimensions of satisfaction and the way of constitution of satisfaction of an important sample of the employees in the Regional administration of Crete and in their connection with the variable of the previous employment. We found statistically important differences for the components of satisfaction from the life, collaboration in and outside from the department, in the social satisfaction and the variable of the years in the service (labour group with <5 years in the service, group with 5-9 years in the service and labour group with 10-15 years in the service). The group with total few years in the work <5, presented smaller social and labour satisfaction than the other previous employment groups. In the other hand the group with many years in the service presents bigger satisfaction than the other groups. Finally, is important to note that the sample present some interesting characteristics.

Real-time generation of infrared ocean scene based on GPU

NASA Astrophysics Data System (ADS)

Jiang, Zhaoyi; Wang, Xun; Lin, Yun; Jin, Jianqiu

2007-12-01

Infrared (IR) image synthesis for ocean scene has become more and more important nowadays, especially for remote sensing and military application. Although a number of works present ready-to-use simulations, those techniques cover only a few possible ways of water interacting with the environment. And the detail calculation of ocean temperature is rarely considered by previous investigators. With the advance of programmable features of graphic card, many algorithms previously limited to offline processing have become feasible for real-time usage. In this paper, we propose an efficient algorithm for real-time rendering of infrared ocean scene using the newest features of programmable graphics processors (GPU). It differs from previous works in three aspects: adaptive GPU-based ocean surface tessellation, sophisticated balance equation of thermal balance for ocean surface, and GPU-based rendering for infrared ocean scene. Finally some results of infrared image are shown, which are in good accordance with real images.

Relativistic distorted-wave collision strengths for Δn = 0 transitions in the 67 Li-like, F-like and Na-like ions with 26 ≤ Z ≤ 92

DOE PAGES

Fontes, Christopher J.; Zhang, Hong Lin

2017-01-01

We calculated relativistic distorted-wave collision strength for all possible Δn=0 transitions, where n denotes the valence shell of the ground level, in the 67 Li-like, F-like and Na-like ions with Z in the range 26 ≤ Z ≤92. This choice produces 3 transitions with n=2 in the Li-like and F-like ions, and 10 transitions with n=3 in the Na-like ions. Moreover, for the Li-like and F-like ions, the calculations were made for the six final, or scattered, electron energies E'=0.008,0.04,0.10,0.21,0.41, and 0.75, where E' is in units of Zmore » $$2\\atop{eff}$$ Ry with Z eff = Z- 1.66 for Li-like ions and Z eff= Z- 6.667 for F-like ions. For the Na-like ions, the calculations were made for the six final electron energies E'=0.0025,0.015,0.04,0.10,0.21, and 0.40, with Z eff = Z- 8.34. In the present calculations, an improved “top-up” method, which employs relativistic plane waves, was used to obtain the high partial-wave contribution for each transition, in contrast to the partial-relativistic Coulomb–Bethe approximation used in previous works by Zhang, Sampson and Fontes [H.L. Zhang, D.H. Sampson, C.J. Fontes, At. Data Nucl. Data Tables 44 (1990) 31; H.L. Zhang, D.H. Sampson, C.J. Fontes, At. Data Nucl. Data Tables 48 (1991) 25; D.H. Sampson, H.L. Zhang, C.J. Fontes, At. Data Nucl. Data Tables 44 (1990) 209]. In those previous works, collision strengths were also provided for Li-, F- and Na-like ions, but for a more comprehensive set of transitions. Finally, the collision strengths covered in the present work should be more accurate than the corresponding data given in those previous works and are presented here to replace those earlier results.« less

Student pharmacists’ career choices: a survey of three Nigerian schools of pharmacy

PubMed Central

Ubaka, Chukwuemeka M.; Ochie, Uche M.; Adibe, Maxwell O.

Background There is little data on the preferences of pharmacy students as regards their future pharmacy job choices in Africa and this has created concerns amongst licensing bodies, employers and also the institutions they graduate from. Objective Career choices and factors that influence these choices of pre-registration pharmacists were assessed. Methods Final and fourth year students from three schools of pharmacy were approached with a previously validated and employed questionnaire comprising questions on future job choices and reasons for that job choice. Data collected were subjected to descriptive and inferential analysis. Results Four hundred and eighty eight students took part in the study (response rate 71.5%). Majority (78.8%) was younger than 26 years and had a work experience (68.2%). Job flexibility was significantly more important to females, while younger students considered salary most important (p<0.05). Hospital and community practice were most preferred career choices. Other demographic factors (especially gender, marital status, previous degree and previous work experience) significantly affected career choices. Conclusions Age, gender, and previous work experience affect career choices of graduating pharmacy students. Patient-oriented practices (e.g. hospital and community) remain the most preferred careers. PMID:24223080

ORCA Project: Research on high-performance parallel computer programming environments. Final report, 1 Apr-31 Mar 90

DOE Office of Scientific and Technical Information (OSTI.GOV)

Snyder, L.; Notkin, D.; Adams, L.

1990-03-31

This task relates to research on programming massively parallel computers. Previous work on the Ensamble concept of programming was extended and investigation into nonshared memory models of parallel computation was undertaken. Previous work on the Ensamble concept defined a set of programming abstractions and was used to organize the programming task into three distinct levels; Composition of machine instruction, composition of processes, and composition of phases. It was applied to shared memory models of computations. During the present research period, these concepts were extended to nonshared memory models. During the present research period, one Ph D. thesis was completed, onemore » book chapter, and six conference proceedings were published.« less

Do Open Access Electronic Theses and Dissertations Diminish Publishing Opportunities in the Sciences?

ERIC Educational Resources Information Center

Ramírez, Marisa L.; McMillan, Gail; Dalton, Joan T.; Hanlon, Ann; Smith, Heather S.; Kern, Chelsea

2014-01-01

In academia, there is a growing acceptance of sharing the final electronic version of graduate work, such as a thesis or dissertation, in an online university repository. Though previous studies have shown that journal editors are willing to consider manuscripts derived from electronic theses and dissertations (ETDs), faculty advisors and graduate…

Constraints and Superspin for SuperPoincare Algebras in Diverse Dimensions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pasqua, Andrea; Zumino, Bruno

2004-04-27

We generalize to arbitrary dimension the construction of a covariant and supersymmetric constraint for the massless superPoincare algebra, which was given for the eleven-dimensional case in a previous work. We also contrast it with a similar construction appropriate to the massive case. Finally we show that the constraint uniquely fixes the representation of the algebra.

Shock compression response of cold-rolled Ni/Al multilayer composites

DOE PAGES

Specht, Paul E.; Weihs, Timothy P.; Thadhani, Naresh N.

2017-01-06

Uniaxial strain, plate-on-plate impact experiments were performed on cold-rolled Ni/Al multilayer composites and the resulting Hugoniot was determined through time-resolved measurements combined with impedance matching. The experimental Hugoniot agreed with that previously predicted by two dimensional (2D) meso-scale calculations. Additional 2D meso-scale simulations were performed using the same computational method as the prior study to reproduce the experimentally measured free surface velocities and stress profiles. Finally, these simulations accurately replicated the experimental profiles, providing additional validation for the previous computational work.

Testing a mediation model of psychotherapy process and outcome in psychodynamic psychotherapy: Previous client distress, psychodynamic techniques, dyadic working alliance, and current client distress.

PubMed

Kivlighan, Dennis M; Hill, Clara E; Ross, Katherine; Kline, Kathryn; Furhmann, Amy; Sauber, Elizabeth

2018-01-05

To test a sequential model of psychotherapy process and outcome, we included previous client distress, therapist psychodynamic techniques, dyadic working alliance, and current client distress. For 114 sets of eight-session segments in 40 cases of psychodynamic psychotherapy, clients completed the Outcome Questionnaire-45 and Inventory of Interpersonal Problems-32 after the first and final session, judges reliably coded one middle sessions on the Psychodynamic subscale of the Multitheoretical List of Therapeutic Interventions, and clients and therapists completed the Working Alliance Inventory after every session. Results indicated that higher use of psychodynamic techniques was associated with higher levels of the working alliance, which in turn was associated decreased client distress; and working alliance was higher later in psychotherapy. There was a significant indirect effect of psychodynamic techniques on decreases in distress mediated by the working alliance. Implications for theory, practice, and research are provided. Clinical or methodological significance of this article: Conducted a longitudinal, latent variable examination of the relationships of psychodynamic techniques and working alliance on client distress. Psychodynamic techniques have an indirect effect on decreases in client distress through the dyadic working alliance.

Warping an atlas derived from serial histology to 5 high-resolution MRIs.

PubMed

Tullo, Stephanie; Devenyi, Gabriel A; Patel, Raihaan; Park, Min Tae M; Collins, D Louis; Chakravarty, M Mallar

2018-06-19

Previous work from our group demonstrated the use of multiple input atlases to a modified multi-atlas framework (MAGeT-Brain) to improve subject-based segmentation accuracy. Currently, segmentation of the striatum, globus pallidus and thalamus are generated from a single high-resolution and -contrast MRI atlas derived from annotated serial histological sections. Here, we warp this atlas to five high-resolution MRI templates to create five de novo atlases. The overall goal of this work is to use these newly warped atlases as input to MAGeT-Brain in an effort to consolidate and improve the workflow presented in previous manuscripts from our group, allowing for simultaneous multi-structure segmentation. The work presented details the methodology used for the creation of the atlases using a technique previously proposed, where atlas labels are modified to mimic the intensity and contrast profile of MRI to facilitate atlas-to-template nonlinear transformation estimation. Dice's Kappa metric was used to demonstrate high quality registration and segmentation accuracy of the atlases. The final atlases are available at https://github.com/CobraLab/atlases/tree/master/5-atlas-subcortical.

Molecular dynamics analysis of the influence of Coulomb and van der Waals interactions on the work of adhesion at the solid-liquid interface

NASA Astrophysics Data System (ADS)

Surblys, Donatas; Leroy, Frédéric; Yamaguchi, Yasutaka; Müller-Plathe, Florian

2018-04-01

We investigated the solid-liquid work of adhesion of water on a model silica surface by molecular dynamics simulations, where a methodology previously developed to determine the work of adhesion through thermodynamic integration was extended to a system with long-range electrostatic interactions between solid and liquid. In agreement with previous studies, the work of adhesion increased when the magnitude of the surface polarity was increased. On the other hand, we found that when comparing two systems with and without solid-liquid electrostatic interactions, which were set to have approximately the same total solid-liquid interfacial energy, former had a significantly smaller work of adhesion and a broader distribution in the interfacial energies, which has not been previously reported in detail. This was explained by the entropy contribution to the adhesion free energy; i.e., the former with a broader energy distribution had a larger interfacial entropy than the latter. While the entropy contribution to the work of adhesion has already been known, as a work of adhesion itself is free energy, these results indicate that, contrary to common belief, wetting behavior such as the contact angle is not only governed by the interfacial energy but also significantly affected by the interfacial entropy. Finally, a new interpretation of interfacial entropy in the context of solid-liquid energy variance was offered, from which a fast way to qualitatively estimate the work of adhesion was also presented.

Improvements In solar dry kiln design

Treesearch

E. M. Wengert

1971-01-01

Interest in solar drying of lumber has increased in recent years because previous results had indicated that: Drying times are shorter and final moisture contents are lower in solar drying than in air drying; much less lumber degrade occurs in solar drying when compared to air drying; and the cost of energy is less in solar drying than in kiln drying. Work in the field...

Systematic Study of Student Understanding of the Relationships between the Directions of Force, Velocity, and Acceleration in One Dimension

ERIC Educational Resources Information Center

Rosenblatt, Rebecca; Heckler, Andrew F.

2011-01-01

We developed an instrument to systematically investigate student conceptual understanding of the relationships between the directions of net force, velocity, and acceleration in one dimension and report on data collected on the final version of the instrument from over 650 students. Unlike previous work, we simultaneously studied all six possible…

Fourth Meeting of the Panel for Evaluation of Experimental Literacy Projects. Final Report.

ERIC Educational Resources Information Center

United Nations Educational, Scientific, and Cultural Organization, Paris (France).

The work of this Panel for the Evaluation of Experimental Literacy Projects was the assessing of how the pattern of evaluation it had previously formulated had been applied in the Experimental World Literacy Programme (EWLP). In the judgment of the Panel, by 1974 evaluation specialists will be able to present a report that will enable Member…

Oscillating-flow regenerator test rig

NASA Technical Reports Server (NTRS)

Wood, J. G.; Gedeon, D. R.

1994-01-01

This report summarizes work performed in setting up and performing tests on a regenerator test rig. An earlier status report presented test results, together with heat transfer correlations, for four regenerator samples (two woven screen samples and two felt metal samples). Lessons learned from this testing led to improvements to the experimental setup, mainly instrumentation as well as to the test procedure. Given funding and time constraints for this project it was decided to complete as much testing as possible while the rig was set up and operational, and to forego final data reduction and analysis until later. Additional testing was performed on several of the previously tested samples as well an on five newly fabricated samples. The following report is a summary of the work performed at OU, with many of the final test results included in raw data form.

Contact mechanics for coated spheres that includes the transition from weak to strong adhesion

DOE PAGES

Reedy, Earl David

2007-09-01

Recently published results for a rigid spherical indenter contacting a thin, linear elastic coating on a rigid planar substrate have been extended to include the case of two contacting spheres, where each sphere is rigid and coated with a thin, linear elastic material. This is done by using an appropriately chosen effective radius and coating modulus. Finally, the earlier work has also been extended to provide analytical results that span the transition between the previously derived Derjaguin–Müller–Toporov (DMT)-like (work of adhesion/coating-modulus ratio is small) and Johnson–Kendall–Roberts (JKR)-like (work of adhesion/coating-modulus ratio is large) limits.

Real-time measurement of size-resolved elemental composition ratio for flame synthesized composite nanoparticle aggregates using a tandem SMPS-ICP-OES

PubMed Central

Reed, Nathan; Fang, Jiaxi; Chavalmane, Sanmathi; Biswas, Pratim

2017-01-01

Composite nanoparticles find application in catalysis, drug delivery, and energy storage and require increasingly fine control of their physical properties and composition. While composite nanoparticles have been widely synthesized and characterized, little work has systematically correlated the initial concentration of precursors and the final composition of flame synthesized composite nanoparticles. This relationship is explored in a diffusion flame aerosol reactor by coupling a scanning mobility particle sizer (SMPS) with an inductively coupled plasma optical emission spectrometer (ICP-OES). A framework for studying the relationship between the initial precursor concentrations of different elements and the final nanoparticle composition is explored. The size-resolved elemental composition was measured by directly injecting size-selected fractions of aggregated magnetite and silicon dioxide composite nanoparticles into the ICP-OES plasma. This work showed a correlation between precursor molar ratio and the measured elemental ratio in the mobility size range of 50 to 140 nm. Building on previous work studying size resolved elemental composition of engineered nanoparticles, the analysis is extended to flame synthesized composite nanoparticle aggregates in this work. PMID:28435179

Real-time measurement of size-resolved elemental composition ratio for flame synthesized composite nanoparticle aggregates using a tandem SMPS-ICP-OES.

PubMed

Reed, Nathan; Fang, Jiaxi; Chavalmane, Sanmathi; Biswas, Pratim

2017-01-01

Composite nanoparticles find application in catalysis, drug delivery, and energy storage and require increasingly fine control of their physical properties and composition. While composite nanoparticles have been widely synthesized and characterized, little work has systematically correlated the initial concentration of precursors and the final composition of flame synthesized composite nanoparticles. This relationship is explored in a diffusion flame aerosol reactor by coupling a scanning mobility particle sizer (SMPS) with an inductively coupled plasma optical emission spectrometer (ICP-OES). A framework for studying the relationship between the initial precursor concentrations of different elements and the final nanoparticle composition is explored. The size-resolved elemental composition was measured by directly injecting size-selected fractions of aggregated magnetite and silicon dioxide composite nanoparticles into the ICP-OES plasma. This work showed a correlation between precursor molar ratio and the measured elemental ratio in the mobility size range of 50 to 140 nm. Building on previous work studying size resolved elemental composition of engineered nanoparticles, the analysis is extended to flame synthesized composite nanoparticle aggregates in this work.

Method to acquire regions of fruit, branch and leaf from image of red apple in orchard

NASA Astrophysics Data System (ADS)

Lv, Jidong; Xu, Liming

2017-07-01

This work proposed a method to acquire regions of fruit, branch and leaf from red apple image in orchard. To acquire fruit image, R-G image was extracted from the RGB image for corrosive working, hole filling, subregion removal, expansive working and opening operation in order. Finally, fruit image was acquired by threshold segmentation. To acquire leaf image, fruit image was subtracted from RGB image before extracting 2G-R-B image. Then, leaf image was acquired by subregion removal and threshold segmentation. To acquire branch image, dynamic threshold segmentation was conducted in the R-G image. Then, the segmented image was added to fruit image to acquire adding fruit image which was subtracted from RGB image with leaf image. Finally, branch image was acquired by opening operation, subregion removal and threshold segmentation after extracting the R-G image from the subtracting image. Compared with previous methods, more complete image of fruit, leaf and branch can be acquired from red apple image with this method.

Improved Radio-Frequency Magneto-Optical Trap of SrF Molecules.

PubMed

Steinecker, Matthew H; McCarron, Daniel J; Zhu, Yuqi; DeMille, David

2016-11-18

We report the production of ultracold, trapped strontium monofluoride (SrF) molecules with number density and phase-space density significantly higher than previously achieved. These improvements are enabled by three distinct changes to our recently-demonstrated scheme for radio-frequency magneto-optical trapping of SrF: modification of the slowing laser beam geometry, addition of an optical pumping laser, and incorporation of a compression stage to the magneto-optical trap. With these improvements, we observe a trapped sample of SrF molecules at density 2.5×10 5  cm -3 and phase-space density 6×10 -14 , each a factor of 4 greater than in previous work. Under different experimental conditions, we observe trapping of up to 10 4 molecules, a factor of 5 greater than in previous work. Finally, by reducing the intensity of the applied trapping light, we observe molecular temperatures as low as 250 μK. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

On the design of learning outcomes for the undergraduate engineer's final year project

NASA Astrophysics Data System (ADS)

Thambyah, Ashvin

2011-03-01

The course for the final year project for engineering students, because of its strongly research-based, open-ended format, tends to not have well defined learning outcomes, which are also not aligned with any accepted pedagogical philosophy or learning technology. To address this problem, the revised Bloom's taxonomy table of Anderson and Krathwohl (2001) is utilised, as suggested previously by Lee and Lai (2007), to design new learning outcomes for the final year project course in engineering education. Based on the expectations of the engineering graduate, and integrating these graduate expectations into the six cognitive processes and four knowledge dimensions of the taxonomy table, 24 learning outcomes have been designed. It is proposed that these 24 learning outcomes be utilised as a suitable working template to inspire more critical evaluation of what is expected to be learnt by engineering students undertaking final year research or capstone projects.

Neck and shoulder disorders in medical secretaries. Part I. Pain prevalence and risk factors.

PubMed

Kamwendo, K; Linton, S J; Moritz, U

1991-01-01

420 medical secretaries took part in a cross-sectional study at examining the prevalence of musculoskeletal disorders as well as the relationship between neck and shoulder pain and possible risk factors. Sixty-three percent had experienced neck pain sometime during the previous year and while 15% had suffered almost constant pain 32% had experienced neck pain only occasionally. Shoulder pain during the previous year had been experienced by 62%, 17% had suffered almost constant pain while 29% experienced pain only occasionally. Fifty-one percent had experienced low back pain. Age and length of employment were significantly related to neck and shoulder pain. Furthermore, working with office machines 5 hours or more per day was associated with a significantly increased risk for neck pain (OR 1.7), shoulder pain (OR 1.9) and headache (OR 1.8). Finally, a poorly experienced psychosocial work environment was significantly related to headache, neck, shoulder and low back pain. The results of this study suggest that work with office machines as well as the psychosocial work environment are important factors in neck and shoulder pain.

Evaluation of superconducting wiggler designs and free-electron laser support: Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1990-10-12

This report consists of copies of previous progress reports, and copies of viewgraphs presented in a talk at Los Alamos. The report describes activities carried out as part of a project to evaluate the design and performance of a superconducting wiggler magnet design. It includes work on evaluating the appropriate materials for the magnet coils and poles, and stress evaluations for the design. It includes work on beam optics through the magnet, and design considerations to optimize extraction: work on the cryocooling system; weight minimization efforts; and design work on the vacuum liner for the magnet. A major concern inmore » all of this design work is heat loads which will be dissipated in different parts of the system during operation, as well as transient events.« less

Heterologous pathway assembly reveals molecular steps of fungal terreic acid biosynthesis.

PubMed

Kong, Chuixing; Huang, Hezhou; Xue, Ying; Liu, Yiqi; Peng, Qiangqiang; Liu, Qi; Xu, Qin; Zhu, Qiaoyun; Yin, Ying; Zhou, Xiangshan; Zhang, Yuanxing; Cai, Menghao

2018-02-01

Terreic acid is a potential anticancer drug as it inhibits Bruton's tyrosine kinase; however, its biosynthetic molecular steps remain unclear. In this work, the individual reactions of terreic acid biosynthesis were determined by stepwise pathway assembly in a heterologous host, Pichia pastoris, on the basis of previous knockout studies in a native host, Aspergillus terreus. Polyketide synthase AtX was found to catalyze the formation of partially reduced polyketide 6-methylsalicylic acid, followed by 3-methylcatechol synthesis by salicylate 1-monooxygenase AtA-mediated decarboxylative hydroxylation of 6-methylsalicylic acid. Our results show that cytochrome P450 monooxygenase AtE hydroxylates 3-methylcatechol, thus producing the next product, 3-methyl-1,2,4-benzenetriol. A smaller putative cytochrome P450 monooxygenase, AtG, assists with this step. Then, AtD causes epoxidation and hydroxyl oxidation of 3-methyl-1,2,4-benzenetriol and produces a compound terremutin, via which the previously unknown function of AtD was identified as cyclooxygenation. The final step involves an oxidation reaction of a hydroxyl group by a glucose-methanol-choline oxidoreductase, AtC, which leads to the final product: terreic acid. Functions of AtD and AtG were determined for the first time. All the genes were reanalyzed and all intermediates and final products were isolated and identified. Our model fully defines the molecular steps and corrects previous results from the literature.

Improving Conceptual Design for Launch Vehicles. The Bimese Concept: A Study of Mission and Economic Options

NASA Technical Reports Server (NTRS)

Olds, John R.; Tooley, Jeffrey

1999-01-01

This report summarizes key activities conducted in the third and final year of the cooperative agreement NCC1-229 entitled "Improving Conceptual Design for Launch Vehicles." This project has been funded by the Vehicle Analysis Branch at NASA's Langley Research Center in Hampton, VA. Work has been performed by the Space Systems Design Lab (SSDL) at the Georgia Institute of Technology, Atlanta, GA. Accomplishments during the first and second years of this project have been previously reported in annual progress reports. This report will focus on the third and final year of the three year activity.

Elucidating nitric oxide synthase domain interactions by molecular dynamics.

PubMed

Hollingsworth, Scott A; Holden, Jeffrey K; Li, Huiying; Poulos, Thomas L

2016-02-01

Nitric oxide synthase (NOS) is a multidomain enzyme that catalyzes the production of nitric oxide (NO) by oxidizing L-Arg to NO and L-citrulline. NO production requires multiple interdomain electron transfer steps between the flavin mononucleotide (FMN) and heme domain. Specifically, NADPH-derived electrons are transferred to the heme-containing oxygenase domain via the flavin adenine dinucleotide (FAD) and FMN containing reductase domains. While crystal structures are available for both the reductase and oxygenase domains of NOS, to date there is no atomic level structural information on domain interactions required for the final FMN-to-heme electron transfer step. Here, we evaluate a model of this final electron transfer step for the heme-FMN-calmodulin NOS complex based on the recent biophysical studies using a 105-ns molecular dynamics trajectory. The resulting equilibrated complex structure is very stable and provides a detailed prediction of interdomain contacts required for stabilizing the NOS output state. The resulting equilibrated complex model agrees well with previous experimental work and provides a detailed working model of the final NOS electron transfer step required for NO biosynthesis. © 2015 The Protein Society.

The irrelevant speech effect and working memory load.

PubMed

Gisselgård, Jens; Petersson, Karl Magnus; Ingvar, Martin

2004-07-01

Irrelevant speech impairs the immediate serial recall of visually presented material. Previously, we have shown that the irrelevant speech effect (ISE) was associated with a relative decrease of regional blood flow in cortical regions subserving the verbal working memory, in particular the superior temporal cortex. In this extension of the previous study, the working memory load was increased and an increased activity as a response to irrelevant speech was noted in the dorsolateral prefrontal cortex. We suggest that the two studies together provide some basic insights as to the nature of the irrelevant speech effect. Firstly, no area in the brain can be ascribed as the single locus of the irrelevant speech effect. Instead, the functional neuroanatomical substrate to the effect can be characterized in terms of changes in networks of functionally interrelated areas. Secondly, the areas that are sensitive to the irrelevant speech effect are also generically activated by the verbal working memory task itself. Finally, the impact of irrelevant speech and related brain activity depends on working memory load as indicated by the differences between the present and the previous study. From a brain perspective, the irrelevant speech effect may represent a complex phenomenon that is a composite of several underlying mechanisms, which depending on the working memory load, include top-down inhibition as well as recruitment of compensatory support and control processes. We suggest that, in the low-load condition, a selection process by an inhibitory top-down modulation is sufficient, whereas in the high-load condition, at or above working memory span, auxiliary adaptive cognitive resources are recruited as compensation. Copyright 2004 Elsevier Inc.

Memory functions in chronic pain: examining contributions of attention and age to test performance.

PubMed

Oosterman, Joukje M; Derksen, Laura C; van Wijck, Albert J M; Veldhuijzen, Dieuwke S; Kessels, Roy P C

2011-01-01

Previous studies have revealed that memory performance is diminished in chronic pain patients. Few studies, however, have assessed multiple components of memory in a single sample. It is currently also unknown whether attentional problems, which are commonly observed in chronic pain, mediate the decline in memory. Finally, previous studies have focused on middle-aged adults, and a possible detrimental effect of aging on memory performance in chronic pain patients has been commonly disregarded. This study, therefore, aimed at describing the pattern of semantic, working, and visual and verbal episodic memory performance in participants with chronic pain, while testing for possible contributions of attention and age to task performance. Thirty-four participants with chronic pain and 32 pain-free participants completed tests of episodic, semantic, and working memory to assess memory performance and a test of attention. Participants with chronic pain performed worse on tests of working memory and verbal episodic memory. A decline in attention explained some, but not all, group differences in memory performance. Finally, no additional effect of age on the diminished task performance in participants with chronic pain was observed. Taken together, the results indicate that chronic pain significantly affects memory performance. Part of this effect may be caused by underlying attentional dysfunction, although this could not fully explain the observed memory decline. An increase in age in combination with the presence of chronic pain did not additionally affect memory performance.

Characterizing short-term stability for Boolean networks over any distribution of transfer functions

DOE PAGES

Seshadhri, C.; Smith, Andrew M.; Vorobeychik, Yevgeniy; ...

2016-07-05

Here we present a characterization of short-term stability of random Boolean networks under arbitrary distributions of transfer functions. Given any distribution of transfer functions for a random Boolean network, we present a formula that decides whether short-term chaos (damage spreading) will happen. We provide a formal proof for this formula, and empirically show that its predictions are accurate. Previous work only works for special cases of balanced families. Finally, it has been observed that these characterizations fail for unbalanced families, yet such families are widespread in real biological networks.

Optical spectroscopy of laser-produced plasmas for standoff isotopic analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harilal, Sivanandan S.; Brumfield, Brian E.; LaHaye, Nicole L.

2018-04-20

This review article covers the present status of isotope detection through emission, absorption, and fluorescence spectroscopy of atoms and molecules in a laser-produced plasma formed from a solid sample. A description of the physics behind isotope shifts in atoms and molecules is presented, followed by the physics behind solid sampling of laser ablation plumes, optical methods for isotope measurements, the suitable physical conditions of laser-produced plasma plumes for isotopic analysis, and the current status. Finally, concluding remarks will be made on the existing gaps between previous works in the literature and suggestions for future work.

Optical spectroscopy of laser-produced plasmas for standoff isotopic analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harilal, S. S.; Brumfield, B. E.; LaHaye, N. L.

This review article covers the present status of isotope detection through emission, absorption, and fluorescence spectroscopy of atoms and molecules in a laser-produced plasma formed from a solid sample. A description of the physics behind isotope shifts in atoms and molecules is presented, followed by the physics behind solid sampling of laser ablation plumes, optical methods for isotope measurements, the suitable physical conditions of laser-produced plasma plumes for isotopic analysis, and the current status. Finally, concluding remarks will be made on the existing gaps between previous works in the literature and suggestions for future work.

Optical spectroscopy of laser-produced plasmas for standoff isotopic analysis

DOE PAGES

Harilal, S. S.; Brumfield, B. E.; LaHaye, N. L.; ...

2018-06-01

This review article covers the present status of isotope detection through emission, absorption, and fluorescence spectroscopy of atoms and molecules in a laser-produced plasma formed from a solid sample. A description of the physics behind isotope shifts in atoms and molecules is presented, followed by the physics behind solid sampling of laser ablation plumes, optical methods for isotope measurements, the suitable physical conditions of laser-produced plasma plumes for isotopic analysis, and the current status. Finally, concluding remarks will be made on the existing gaps between previous works in the literature and suggestions for future work.

Kansas State Plan for Career Education. Final Report. F.Y. 1978, July 1, 1977--September 30, 1978.

ERIC Educational Resources Information Center

InterAmerica Research Associates, Lawrence, KS.

A two-year project was undertaken in Kansas to develop a five-year plan for career education in the state. The first year resulted in (1) a brief summary of previous work done in Kansas since the introduction of the career education concept, (2) establishment of a definition of career education, (3) a description of various resources that can be…

Move Affords Many Advantages to EML | Poster

Cancer.gov

By Nancy Parrish, Staff Writer Ulrich Baxa, Ph.D., director of the Electron Microscopy Laboratory (EML), enjoys finally having his staff all in one place. “Our lab is now all in one location, as compared to our previous situation, with two different locations,” he said. “This will make daily work much easier, in particular for me since I am able to have an office next to the

The relativistic equations of stellar structure and evolution. Stars with degenerate neutron cores. 1: Structure of equilibrium models

NASA Technical Reports Server (NTRS)

Thorne, K. S.; Zytkow, A. N.

1976-01-01

The general relativistic equations of stellar structure and evolution are reformulated in a notation which makes easy contact with Newtonian theory. Also, a general relativistic version of the mixing-length formalism for convection is presented. Finally, it is argued that in previous work on spherical systems general relativity theorists have identified the wrong quantity as "total mass-energy inside radius r."

Small instrument to volcanic seismic signals

NASA Astrophysics Data System (ADS)

Carreras, Normandino; Gomariz, Spartacus; Manuel, Antoni

2014-05-01

Currently, the presence of volcanoes represents a threat to their local populations, and for this reason, scientific communities invest resources to monitor seismic activity of an area, and to obtain information to identify risk situations. To perform such monitoring, it can use different general purpose acquisition systems commercially available, but these devices do not meet to the specifications of reduced dimensions, low weight, low power consumption and low cost. These features allow the system works in autonomous mode for a long period of time, and it makes easy to be carried and to be installed. In the line of designing a volcanic acquisition system with the previously mentioned specifications, exists the Volcanology Department of CSIC, developers of a system with some of these specifications. The objective of this work is to improve the energy consumption requirements of the previous system, providing three channels of data acquisition and with the possibility to transmit data acquisition via radio frequency to a base station, allowing operation it in remote mode. The developed acquisition system consists of three very low-power acquisition modules of Texas Instruments (ADS1246), and this is designed to capture information of the three coordinate axes. A microprocessor also of Texas Instruments (MSP430F5438) is used to work in low-power, due to it is ready to run this consumption and also takes advantage the power save mode in certain moments when system is not working. This system is configurable by serial port, and it has a SD memory to storage data. Contrast to the previous system, it has a RF communication module incorporated specially to work in remote mode of Lynx (YLX-TRM8053-025-05), and boasts also with a GPS module which keeps the time reference synchronized with module of SANAV (GM-1315LA). Thanks to this last selection of components, it is designed a small system about 106 x 106 mm. Assuming that the power supply system is working during all the time, except GPS (it works the 1.4% of time) and the RF communications (it works the 20% of time), it has been able to obtain experimental consumption data of prototype developed. That is the reason why the final power supply of system with one channel active is of 110,5mW when using the communication module. If it calculates the power supply without communication, this consumes about 71mW. The new system needs to work at 3.3V, and the calculations have made in base of that. In contrast, the previous system needs 12V, and does not use RF communications. In order to compare those two versions, is used the power supply as reference, up to 696mW in this previous system. Finally it can be concluded that the implemented electronic design has up to three channels to acquire seismic data, it has the ability to transmit these data by radio frequency to a base station, and power consumption is lower than the initial prototype. The experimental results allow providing an operating time of a year, with weight of 4,84 Kg if the equipment used li-ion batteries.

Vortex lattices in binary mixtures of repulsive superfluids

NASA Astrophysics Data System (ADS)

Mingarelli, Luca; Keaveny, Eric E.; Barnett, Ryan

2018-04-01

We present an extension of the framework introduced in previous work [L. Mingarelli, E. E. Keaveny, and R. Barnett, J. Phys.: Condens. Matter 28, 285201 (2016), 10.1088/0953-8984/28/28/285201] to treat multicomponent systems, showing that new degrees of freedom are necessary in order to obtain the desired boundary conditions. We then apply this extended framework to the coupled Gross-Pitaevskii equations to investigate the ground states of two-component systems with equal masses, thereby extending previous work in the lowest Landau limit [E. J. Mueller and T.-L. Ho, Phys. Rev. Lett. 88, 180403 (2002), 10.1103/PhysRevLett.88.180403] to arbitrary interactions within Gross-Pitaevskii theory. We show that away from the lowest Landau level limit, the predominant vortex lattice consists of two interlaced triangular lattices. Finally, we derive a linear relation which accurately describes the phase boundaries in the strong interacting regimes.

Development of a Bio-Equivalent Ultraviolet Dosimeter to Monitor the Capacity for Vitamin D Synthesis of Sunlight Final Report CRADA No. TC02086.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, C. F.; Wood, D.

This project represents a collaborative effort between Lawrence Livermore National Security, LLC as manager and operator of Lawrence Livermore National Laboratory (LLNL) and Rhyolite Technology Group, Inc. (Rhyolite) to develop concepts and designs for a consumer ultraviolet (UV) biodosimeter based on the human biochemistry of Vitamin D synthesis. Rhyolite was established to engage in product development, licensing and consulting for the manufacture and supply of new products worldwide. Rhyolite worked jointly with LLNL and the Kiev Institute of Physics (KIP) in Ukraine to leverage previously developed UV sensor technologies by extending the previous work into commercially viable products. The projectmore » consisted primarily of the scientific, engineering and business activities needed to develop the UV bio-dosimeter for applications that include health and industrial measurement of ultraviolet radiation.« less

Michael Maier--nine newly discovered letters.

PubMed

Lenke, Nils; Roudet, Nicolas; Tilton, Hereward

2014-02-01

The authors provide a transcription, translation, and evaluation of nine newly discovered letters from the alchemist Michael Maier (1568-1622) to Gebhardt Johann von Alvensleben (1576-1631), a noble landholder in the vicinity of Magdeburg. Stemming from the final year of his life, this correspondence casts new light on Maier's biography, detailing his efforts to secure patronage amid the financial crisis of the early Thirty Years' War. While his ill-fated quest to perfect potable gold continued to form the central focus of his patronage suits, Maier also offered his services in several arts that he had condemned in his printed works, namely astrology and "supernatural" magic. Remarks concerning his previously unknown acquaintance with Heinrich Khunrath call for a re-evaluation of Maier's negotiation of the discursive boundaries between Lutheran orthodoxy and Paracelsianism. The letters also reveal Maier's substantial contribution to a work previously ascribed solely to the English alchemist Francis Anthony.

Code Modernization of VPIC

NASA Astrophysics Data System (ADS)

Bird, Robert; Nystrom, David; Albright, Brian

2017-10-01

The ability of scientific simulations to effectively deliver performant computation is increasingly being challenged by successive generations of high-performance computing architectures. Code development to support efficient computation on these modern architectures is both expensive, and highly complex; if it is approached without due care, it may also not be directly transferable between subsequent hardware generations. Previous works have discussed techniques to support the process of adapting a legacy code for modern hardware generations, but despite the breakthroughs in the areas of mini-app development, portable-performance, and cache oblivious algorithms the problem still remains largely unsolved. In this work we demonstrate how a focus on platform agnostic modern code-development can be applied to Particle-in-Cell (PIC) simulations to facilitate effective scientific delivery. This work builds directly on our previous work optimizing VPIC, in which we replaced intrinsic based vectorisation with compile generated auto-vectorization to improve the performance and portability of VPIC. In this work we present the use of a specialized SIMD queue for processing some particle operations, and also preview a GPU capable OpenMP variant of VPIC. Finally we include a lessons learnt. Work performed under the auspices of the U.S. Dept. of Energy by the Los Alamos National Security, LLC Los Alamos National Laboratory under contract DE-AC52-06NA25396 and supported by the LANL LDRD program.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kervin, Karina E.; Cook, Robert B.; Michener, William K.

Conventional wisdom makes the suggestion that there are benefits to the creation of shared repositories of scientific data. Funding agencies require that the data from sponsored projects be shared publicly, but individual researchers often see little personal benefit to offset the work of creating easily sharable data. These conflicting forces have led to the emergence of a new role to support researchers: data managers. This paper identifies key differences between the socio-technical context of data managers and other "human infrastructure" roles articulated previously in Computer Supported Cooperative Work (CSCW) literature and summarizes the challenges that data managers face when acceptingmore » data for archival and reuse. Finally, while data managers' work is critical for advancing science and science policy, their work is often invisible and under-appreciated since it takes place behind the scenes.« less

Advanced Materials in Support of EERE Needs to Advance Clean Energy Technologies Program Implementation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liby, Alan L; Rogers, Hiram

The goal of this activity was to carry out program implementation and technical projects in support of the ARRA-funded Advanced Materials in Support of EERE Needs to Advance Clean Energy Technologies Program of the DOE Advanced Manufacturing Office (AMO) (formerly the Industrial Technologies Program (ITP)). The work was organized into eight projects in four materials areas: strategic materials, structural materials, energy storage and production materials, and advanced/field/transient processing. Strategic materials included work on titanium, magnesium and carbon fiber. Structural materials included work on alumina forming austentic (AFA) and CF8C-Plus steels. The advanced batteries and production materials projects included work onmore » advanced batteries and photovoltaic devices. Advanced/field/transient processing included work on magnetic field processing. Details of the work in the eight projects are available in the project final reports which have been previously submitted.« less

Move Affords Many Advantages to EML | Poster

Cancer.gov

By Nancy Parrish, Staff Writer Ulrich Baxa, Ph.D., director of the Electron Microscopy Laboratory (EML), enjoys finally having his staff all in one place. “Our lab is now all in one location, as compared to our previous situation, with two different locations,” he said. “This will make daily work much easier, in particular for me since I am able to have an office next to the other EML staff.”

Dynamic bin packing problem

NASA Technical Reports Server (NTRS)

Dikshit, Piyush; Guimaraes, Katia; Ramamurthy, Maya; Agrawala, Ashok K.; Larsen, Ronald L.

1989-01-01

In a previous work we have defined a general architecture model for autonomous systems, which can be mapped easily to describe the functions of any automated system (SDAG-86-01). In this note, we use the model to describe the problem of thermal management in space stations. First we briefly review the architecture, then we present the environment of our application, and finally we detail the specific function for each functional block of the architecture for that environment.

An Exploratory Analysis of Projection-Standard Variables (Screen Size, Image Size and Image Contrast) in Terms of Their Effects on the Speed and Accuracy of Discrimination. Final Report.

ERIC Educational Resources Information Center

Metcalf, Richard M.

Although there has been previous research concerned with image size, brightness, and contrast in projection standards, the work has lacked careful conceptualization. In this study, size was measured in terms of the visual angle subtended by the material, brightness was stated in foot-lamberts, and contrast was defined as the ratio of the…

Rotary Valve & Beamline Highlights for Fiscal Year 2017

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fitsos, P

This Fiscal Year (FY) work was divided between continued testing and characterization work of the Rotary Valve (RV) and mechanical engineering support for the beamline hardware stands. This configuration is more like the final setup with the accelerator firing deuterons down the evacuated beamline toward the RV for interaction with the deuterium and neutron production. The beamline cells were part of an experiment to reduce the impact that RV gas would have on the beamline vacuum. This work will be reported separately from this report. Previous testing had been with the beamline at atmospheric pressure and now the goal wasmore » to get test results of the RV with it connected to a beamline that’s running at some level of vacuum.« less

Measure Guideline: Guide to Attic Air Sealing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lstiburek, Joseph

2014-09-01

The purpose of this measure guideline is to provide information and recommendations for the preparation work necessary prior to adding attic insulation. Even though the purpose of this guide is to save energy, health, safety, and durability should not be compromised by energy efficiency. Accordingly, combustion safety and ventilation for indoor air quality are addressed first. Durability and attic ventilation then follow. Finally, to maximize energy savings, air sealing is completed prior to insulating. The guide is intended for home remodelers, builders, insulation contractors, mechanical contractors, general contractors who have previously done remodeling and homeowners as a guide to themore » work that needs to be done.« less

Validation of holistic nursing competencies: role-delineation study, 2012.

PubMed

Erickson, Helen Lorraine; Erickson, Margaret Elizabeth; Campbell, Joan A; Brekke, Mary E; Sandor, M Kay

2013-12-01

The American Holistic Nurses Credentialing Corporation (AHNCC), certifying body for nurses practicing within the precepts of holistic nursing, uses a systematic process to guide program development. A previous publication described their early work that distinguished basic and advanced holistic nursing and development of related examinations. A more recent publication described the work of AHNCC from 2004 to 2012, including a role-delineation study (RDS) that was undertaken to identify and validate competencies currently used by holistic nurses. A final report describes the RDS design, methods, and raw data information. This article discusses AHNCC's goals for undertaking the 2012 Holistic Nursing RDS and the implications for the certification programs.

Recent Progress on Modeling Slip Deformation in Shape Memory Alloys

NASA Astrophysics Data System (ADS)

Sehitoglu, H.; Alkan, S.

2018-03-01

This paper presents an overview of slip deformation in shape memory alloys. The performance of shape memory alloys depends on their slip resistance often quantified through the Critical Resolved Shear Stress (CRSS) or the flow stress. We highlight previous studies that identify the active slip systems and then proceed to show how non- Schmid effects can be dominant in shape memory slip behavior. The work is mostly derived from our recent studies while we highlight key earlier works on slip deformation. We finally discuss the implications of understanding the role of slip on curtailing the transformation strains and also the temperature range over which superelasticity prevails.

[Activities of Colorado University

NASA Technical Reports Server (NTRS)

Snow, Theodore P.; Bierbaum, Veronica

2003-01-01

During the report period we completed several studies and embarked on a new set of laboratory experiments. We also hired a new post-doctoral Research Associate, Momir Stepanovic, who has gradually assumed leadership in the laboratory work. The other person involved has been graduate student Brian Eichelberger, who will complete his Ph.D. based on this work by late spring of this year. We have also continued to collaborate with our previous postdoctoral Research Associate, Valery Le Page, through a consulting arrangement. In the following sections we summarize work that has been completed and either in print, in press, or in final stages of preparation for publication; current work being carried out in the laboratory; and plans for the coming year. Work completed in 2002: 1. Modeling the physical and chemical states of PAHs in the diffuse interstellar medium. 2. Hydrogenation and charge states of polycyclic aromatic hydrocarbons in diffuse clouds. 3. Laboratory studies of chemical reactions involving carbon chain anions.

A facilitative effect of negative affective valence on working memory.

PubMed

Gotoh, Fumiko; Kikuchi, Tadashi; Olofsson, Ulrich

2010-06-01

Previous studies have shown that negatively valenced information impaired working memory performance due to an attention-capturing effect. The present study examined whether negative valence could also facilitate working memory. Affective words (negative, neutral, positive) were used as retro-cues in a working memory task that required participants to remember colors at different spatial locations on a computer screen. Following the cue, a target detection task was used to either shift attention to a different location or keep attention at the same location as the retro-cue. Finally, participants were required to discriminate the cued color from a set of distractors. It was found that negative cues yielded shorter response times (RTs) in the attention-shift condition and longer RTs in the attention-stay condition, compared with neutral and positive cues. The results suggest that negative affective valence may enhance working memory performance (RTs), provided that attention can be disengaged.

Evaluating Teachers' Preparedness to Work With Students Who Are Deaf and Hard of Hearing With Disabilities.

PubMed

Guardino, Caroline

2015-01-01

A national survey was conducted to determine the needs of teachers and service providers working with students who are deaf and hard of hearing with disabilities (DWD). Quantitative and qualitative questions were asked regarding knowledge of, training with, and strategies used with students who are DWD. Responses from 264 professionals working with this population are reported. Results are reviewed and tied to previous research before and after the 2008 revalidation of the Council on Education of the Deaf standards for teachers of the deaf. Final recommendations are made for (a) virtual learning opportunities, (b) hands-on field experiences and course work in teacher preparation programs, and (c) empirically based research. By understanding the needs of professionals who are currently working with students who are DWD, researchers can help improve teacher preparation programs as well as improve the educational systems currently in place for these learners.

Relativistic distorted-wave collision strengths for Δn = 0 transitions in the 67 Li-like, F-like and Na-like ions with 26 ≤ Z ≤ 92

NASA Astrophysics Data System (ADS)

Fontes, Christopher J.; Zhang, Hong Lin

2017-01-01

Relativistic distorted-wave collision strengths have been calculated for all possible Δn = 0 transitions, where n denotes the valence shell of the ground level, in the 67 Li-like, F-like and Na-like ions with Z in the range 26 ≤ Z ≤ 92. This choice produces 3 transitions with n = 2 in the Li-like and F-like ions, and 10 transitions with n = 3 in the Na-like ions. For the Li-like and F-like ions, the calculations were made for the six final, or scattered, electron energies E‧ = 0.008 , 0.04 , 0.10 , 0.21 , 0.41, and 0.75, where E‧ is in units of Zeff2 Ry with Zeff = Z - 1.66 for Li-like ions and Zeff = Z - 6.667 for F-like ions. For the Na-like ions, the calculations were made for the six final electron energies E‧ = 0.0025 , 0.015 , 0.04 , 0.10 , 0.21, and 0.40, with Zeff = Z - 8.34. In the present calculations, an improved "top-up" method, which employs relativistic plane waves, was used to obtain the high partial-wave contribution for each transition, in contrast to the partial-relativistic Coulomb-Bethe approximation used in previous works by Zhang, Sampson and Fontes [H.L. Zhang, D.H. Sampson, C.J. Fontes, At. Data Nucl. Data Tables 44 (1990) 31; H.L. Zhang, D.H. Sampson, C.J. Fontes, At. Data Nucl. Data Tables 48 (1991) 25; D.H. Sampson, H.L. Zhang, C.J. Fontes, At. Data Nucl. Data Tables 44 (1990) 209]. In those previous works, collision strengths were also provided for Li-, F- and Na-like ions, but for a more comprehensive set of transitions. The collision strengths covered in the present work should be more accurate than the corresponding data given in those previous works and are presented here to replace those earlier results.

Final Work Plan: Targeted Investigation at York, Nebraska

DOE Office of Scientific and Technical Information (OSTI.GOV)

LaFreniere, Lorraine M.

The targeted investigation at York will be implemented in phases, so that data collected and interpretations developed at each stage of the program can be evaluated to guide subsequent phases most effectively. Section 2 of this Work Plan presents a brief overview of the York site, its geologic and hydrologic setting, and the previous CCC/USDA investigations. Section 3, outlines the proposed technical program for the targeted investigation, and Section 4 describes the investigative methods to be employed. A community relations plan is in Section 5, and Section 6 includes health and safety information. In addition to this site-specific Work Plan,more » the Master Work Plan (Argonne 2002) developed by Argonne for CCC/USDA investigations in Nebraska should be consulted for complete details of the methods and procedures to be used at York.« less

Flora of the Fraser Experimental Forest, Colorado. Forest Service general technical report (Final)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Popovich, S.J.; Shepperd, W.D.; Reichert, D.W.

1993-08-01

The report lists 441 vascular plant taxa in 228 genera and 63 families encountered on the 9,300-ha Fraser Experimental Forest in central Colorado. Synonyms appearing in previous publications and other works pertaining to the Fraser Experimental Forest, as well as appropriate Colorado floras and less-technical field guides, are included. Plant communities and habitats are discussed, and a list of 54 lichens is also presented. A glossary of related terms is included.

Optimized Solvent for Energy-Efficient, Environmentally-Friendly Capture of CO{sub 2} at Coal-Fired Power Plants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Farthing, G. A.; Rimpf, L. M.

The overall goal of this project, as originally proposed, was to optimize the formulation of a novel solvent as a critical enabler for the cost-effective, energy-efficient, environmentally-friendly capture of CO{sub 2} at coal-fired utility plants. Aqueous blends of concentrated piperazine (PZ) with other compounds had been shown to exhibit high rates of CO{sub 2} absorption, low regeneration energy, and other desirable performance characteristics during an earlier 5-year development program conducted by B&W. The specific objective of this project was to identify PZ-based solvent formulations that globally optimize the performance of coal-fired power plants equipped with CO{sub 2} scrubbing systems. Whilemore » previous solvent development studies have tended to focus on energy consumption and absorber size, important issues to be sure, the current work seeks to explore, understand, and optimize solvent formulation across the full gamut of issues related to commercial application of the technology: capital and operating costs, operability, reliability, environmental, health and safety (EH&S), etc. Work on the project was intended to be performed under four budget periods. The objective of the work in the first budget period has been to identify several candidate formulations of a concentrated PZ-based solvent for detailed characterization and evaluation. Work in the second budget period would generate reliable and comprehensive property and performance data for the identified formulations. Work in the third budget period would quantify the expected performance of the selected formulations in a commercial CO{sub 2} scrubbing process. Finally, work in the fourth budget period would provide a final technology feasibility study and a preliminary technology EH&S assessment. Due to other business priorities, however, B&W has requested that this project be terminated at the end of the first budget period. This document therefore serves as the final report for this project. It is the first volume of the two-volume final report and summarizes Budget Period 1 accomplishments under Tasks 1-5 of the project, including the selection of four solvent formulations for further study.« less

The Work Role Functioning Questionnaire v2.0 Showed Consistent Factor Structure Across Six Working Samples.

PubMed

Abma, Femke I; Bültmann, Ute; Amick Iii, Benjamin C; Arends, Iris; Dorland, Heleen F; Flach, Peter A; van der Klink, Jac J L; van de Ven, Hardy A; Bjørner, Jakob Bue

2017-09-09

Objective The Work Role Functioning Questionnaire v2.0 (WRFQ) is an outcome measure linking a persons' health to the ability to meet work demands in the twenty-first century. We aimed to examine the construct validity of the WRFQ in a heterogeneous set of working samples in the Netherlands with mixed clinical conditions and job types to evaluate the comparability of the scale structure. Methods Confirmatory factor and multi-group analyses were conducted in six cross-sectional working samples (total N = 2433) to evaluate and compare a five-factor model structure of the WRFQ (work scheduling demands, output demands, physical demands, mental and social demands, and flexibility demands). Model fit indices were calculated based on RMSEA ≤ 0.08 and CFI ≥ 0.95. After fitting the five-factor model, the multidimensional structure of the instrument was evaluated across samples using a second order factor model. Results The factor structure was robust across samples and a multi-group model had adequate fit (RMSEA = 0.63, CFI = 0.972). In sample specific analyses, minor modifications were necessary in three samples (final RMSEA 0.055-0.080, final CFI between 0.955 and 0.989). Applying the previous first order specifications, a second order factor model had adequate fit in all samples. Conclusion A five-factor model of the WRFQ showed consistent structural validity across samples. A second order factor model showed adequate fit, but the second order factor loadings varied across samples. Therefore subscale scores are recommended to compare across different clinical and working samples.

Scalable detection of statistically significant communities and hierarchies, using message passing for modularity

PubMed Central

Zhang, Pan; Moore, Cristopher

2014-01-01

Modularity is a popular measure of community structure. However, maximizing the modularity can lead to many competing partitions, with almost the same modularity, that are poorly correlated with each other. It can also produce illusory ‘‘communities’’ in random graphs where none exist. We address this problem by using the modularity as a Hamiltonian at finite temperature and using an efficient belief propagation algorithm to obtain the consensus of many partitions with high modularity, rather than looking for a single partition that maximizes it. We show analytically and numerically that the proposed algorithm works all of the way down to the detectability transition in networks generated by the stochastic block model. It also performs well on real-world networks, revealing large communities in some networks where previous work has claimed no communities exist. Finally we show that by applying our algorithm recursively, subdividing communities until no statistically significant subcommunities can be found, we can detect hierarchical structure in real-world networks more efficiently than previous methods. PMID:25489096

The dual-basin landscape in GFP folding

PubMed Central

Andrews, Benjamin T.; Gosavi, Shachi; Finke, John M.; Onuchic, José N.; Jennings, Patricia A.

2008-01-01

Recent experimental studies suggest that the mature GFP has an unconventional landscape composed of an early folding event with a typical funneled landscape, followed by a very slow search and rearrangement step into the locked, active chromophore-containing structure. As we have shown previously, the substantial difference in time scales is what generates the observed hysteresis in thermodynamic folding. The interconversion between locked and the soft folding structures at intermediate denaturant concentrations is so slow that it is not observed under the typical experimental observation time. Simulations of a coarse-grained model were used to describe the fast folding event as well as identify native-like intermediates on energy landscapes enroute to the fluorescent native fold. Interestingly, these simulations reveal structural features of the slow dynamic transition to chromophore activation. Experimental evidence presented here shows that the trapped, native-like intermediate has structural heterogeneity in residues previously linked to chromophore formation. We propose that the final step of GFP folding is a “locking” mechanism leading to chromophore formation and high stability. The combination of previous experimental work and current simulation work is explained in the context of a dual-basin folding mechanism described above. PMID:18713871

Double-parton scattering effects in D0B+ and B+B+ meson-meson pair production in proton-proton collisions at the LHC

NASA Astrophysics Data System (ADS)

Maciuła, Rafał; Szczurek, Antoni

2018-05-01

We extend our previous studies of double-parton scattering (DPS) to simultaneous production of c c ¯ and b b ¯ and production of two pairs of b b ¯. The calculation is performed within a factorized ansatz. Each parton scattering is calculated within the kT-factorization approach. The hadronization is done with the help of fragmentation functions. Production of D mesons in our framework was tested in our previous works. Here, we present our predictions for B mesons. A good agreement is achieved with the LHCb data. We present our results for c c ¯b b ¯ and b b ¯b b ¯ final states. For completeness, we compare results for double- and single-parton scattering (SPS). As for the c c ¯c c ¯ final state, the DPS dominates over the SPS, especially for small transverse momenta. We present several distributions and integrated cross sections with realistic cuts for simultaneous production of D0B+ and B+B+, suggesting future experimental studies at the LHC.

A new symmetrical quasi-classical model for electronically non-adiabatic processes: Application to the case of weak non-adiabatic coupling

DOE PAGES

Cotton, Stephen J.; Miller, William H.

2016-10-14

Previous work has shown how a symmetrical quasi-classical (SQC) windowing procedure can be used to quantize the initial and final electronic degrees of freedom in the Meyer-Miller (MM) classical vibronic (i.e, nuclear + electronic) Hamiltonian, and that the approach provides a very good description of electronically non-adiabatic processes within a standard classical molecular dynamics framework for a number of benchmark problems. This study explores application of the SQC/MM approach to the case of very weak non-adiabatic coupling between the electronic states, showing (as anticipated) how the standard SQC/MM approach used to date fails in this limit, and then devises amore » new SQC windowing scheme to deal with it. Finally, application of this new SQC model to a variety of realistic benchmark systems shows that the new model not only treats the weak coupling case extremely well, but it is also seen to describe the “normal” regime (of electronic transition probabilities ≳ 0.1) even more accurately than the previous “standard” model.« less

A new symmetrical quasi-classical model for electronically non-adiabatic processes: Application to the case of weak non-adiabatic coupling

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cotton, Stephen J.; Miller, William H.

Previous work has shown how a symmetrical quasi-classical (SQC) windowing procedure can be used to quantize the initial and final electronic degrees of freedom in the Meyer-Miller (MM) classical vibronic (i.e, nuclear + electronic) Hamiltonian, and that the approach provides a very good description of electronically non-adiabatic processes within a standard classical molecular dynamics framework for a number of benchmark problems. This study explores application of the SQC/MM approach to the case of very weak non-adiabatic coupling between the electronic states, showing (as anticipated) how the standard SQC/MM approach used to date fails in this limit, and then devises amore » new SQC windowing scheme to deal with it. Finally, application of this new SQC model to a variety of realistic benchmark systems shows that the new model not only treats the weak coupling case extremely well, but it is also seen to describe the “normal” regime (of electronic transition probabilities ≳ 0.1) even more accurately than the previous “standard” model.« less

Dynamical density functional theory for arbitrary-shape colloidal fluids including inertia and hydrodynamic interactions

NASA Astrophysics Data System (ADS)

Duran-Olivencia, Miguel A.; Goddard, Ben; Kalliadasis, Serafim

2015-11-01

Over the last few decades the classical density-functional theory (DFT) and its dynamic extensions (DDFTs) have become a remarkably powerful tool in the study of colloidal fluids. Recently there has been extensive research to generalise all previous DDFTs finally yielding a general DDFT equation (for spherical particles) which takes into account both inertia and hydrodynamic interactions (HI) which strongly influence non-equilibrium properties. The present work will be devoted to a further generalisation of such a framework to systems of anisotropic particles. To this end, the kinetic equation for the Brownian particle distribution function is derived starting from the Liouville equation and making use of Zwanzig's projection-operator techniques. By averaging over all but one particle, a DDFT equation is finally obtained with some similarities to that for spherical colloids. However, there is now an inevitable translational-rotational coupling which affects the diffusivity of asymmetric particles. Lastly, in the overdamped (high friction) limit the theory is notably simplified leading to a DDFT equation which agrees with previous derivations. We acknowledge financial support from European Research Council via Advanced Grant No. 247031.

Parameter identification for nonlinear aerodynamic systems

NASA Technical Reports Server (NTRS)

Pearson, Allan E.

1993-01-01

This final technical report covers a three and one-half year period preceding February 28, 1993 during which support was provided under NASA Grant NAG-1-1065. Following a general description of the system identification problem and a brief survey of methods to attack it, the basic ideas behind the approach taken in this research effort are presented. The results obtained are described with reference to the published work, including the five semiannual progress reports previously submitted and two interim technical reports.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boehm, Celine; Ascasibar, Yago

In a previous work, it was found that the light dark matter scenario could be a possible explanation to the 511 keV emission line detected at the center of our galaxy. Here, we show that hints of this scenario may also have been discovered in particle physics experiments. This could explain the discrepancy between the measurement of the fine structure constant and the value referenced in the CODATA. Finally, our results indicate that some of the light dark matter features could be tested in accelerators. Their discovery might favor N=2 supersymmetry.

Proceedings of the Annual Conference of the Military Testing Association (19th), 17-21 October 1977, San Antonio, Texas

DTIC Science & Technology

1979-11-01

to-?ir kills, especially since we will probably be atle to field only a relatively small number of fighter pilots in future wars. Fighter pilots have...Education and Training, Information, And Legal, too many colonel positlons were allocated. Overall, many jobs wer found to be undergraded, especially at the...t preparing the final eppmntice progress/status report, 4e avy C :-vs educacion specialist will regard previous work experience as distri±xtnd

The entrepreneurial revolution in health care delivery.

PubMed

Silver, A D

1987-06-01

The rapid changes in the health marketplace have opened the door for entrepreneurs. The author shows how entrepreneurs seek previously unthought of solutions to problems and through a team effort increase corporate value. According to the author, there is a specific profile of the successful entrepreneur. The qualities of the entrepreneur and the managers that work with them, therefore, are discussed in detail. Finally, several examples of problems in health care that present entrepreneurial opportunities are presented. The author includes scenarios for taking advantage of these opportunities.

Microlaser-based compact optical neuro-processors (Invited Paper)

NASA Astrophysics Data System (ADS)

Paek, Eung Gi; Chan, Winston K.; Zah, Chung-En; Cheung, Kwok-wai; Curtis, L.; Chang-Hasnain, Constance J.

1992-10-01

This paper reviews the recent progress in the development of holographic neural networks using surface-emitting laser diode arrays (SELDAs). Since the previous work on ultrafast holographic memory readout system and a robust incoherent correlator, progress has been made in several areas: the use of an array of monolithic `neurons' to reconstruct holographic memories; two-dimensional (2-D) wavelength-division multiplexing (WDM) for image transmission through a single-mode fiber; and finally, an associative memory using time- division multiplexing (TDM). Experimental demonstrations on these are presented.

Muon neutrino CCQE at MINERvA

DOE PAGES

Betancourt, M.

2016-12-13

A precise understanding of quasi-elastic interactions is crucial to measure neutrino oscillations. The MINERvA experiment is currently working on different analyses of muon neutrino charged current quasi-elastic interactions. Here, we present updates to the previous quasi-elastic measurement, using a new flux, and we present the status of several analyses in progress; including double differential cross sections, a study of final state interactions using a sample with muon and a proton and the status of the CCQE analysis in the medium energy neutrino beam.

ILEWG technology roadmap for Moon exploration

NASA Astrophysics Data System (ADS)

Foing, Bernard H.

2008-04-01

We discuss the charter and activities of the International Lunar Exploration Working Group (ILEWG), and give an update from the related ILEWG task groups. We discuss the different rationale and technology roadmap for Moon exploration, as debated in previous ILEWG conferences. The Technology rationale includes: 1) The advancement of instrumentation: 2) Technologies in robotic and human exploration 3) Moon-Mars Exploration can inspire solutions to global Earth sustained development. We finally discuss a possible roadmap for development of technologies necessary for Moon and Mars exploration.

Millimeter and Submillimeter Wave Spectroscopy of Higher Energy Conformers of 1,2-PROPANEDIOL

NASA Astrophysics Data System (ADS)

Zakharenko, Olena; Bossa, Jean-Baptiste; Lewen, Frank; Schlemmer, Stephan; Müller, Holger S. P.

2017-06-01

We have performed a study of the millimeter/submillimeter wave spectrum of four higher energy conformers of 1,2-propanediol (continuation of the previous study on the three lowest energy conformers. The present analysis of rotational transitions carried out in the frequency range 38 - 400 GHz represents a significant extension of previous microwave work. The new data were combined with previously-measured microwave transitions and fitted using a Watson's S-reduced Hamiltonian. The final fits were within experimental accuracy, and included spectroscopic parameters up to sixth order of angular momentum, for the ground states of the four higher energy conformers following previously studied ones: g'Ga, gG'g', aGg' and g'Gg. The present analysis provides reliable frequency predictions for astrophysical detection of 1,2-propanediol by radio telescope arrays at millimeter wavelengths. J.-B. Bossa, M.H. Ordu, H.S.P. Müller, F. Lewen, S. Schlemmer, A&A 570 (2014) A12)

Spectral Measurements of Alpha-induced Radioluminescence in Various Gases

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brett, Jaclyn; Koehler, Katrina Elizabeth; Bischak, Michael

Radioluminescent emission in Ar, N 2, O 2, and dry air at P=1 atm was observed induced by 5 MeV α particles. The wavelength range with a single detector spanned 250–1100 nm, extending the range well into the UV and IR bands with a single detector. Measured spectral lines for alpha-induced luminescence were corrected for detector transmission and intensities compared to previous work. The exploration of multiple gases over a wide frequency range opens the door to security and remote sensing applications, where different environments are routinely encountered. Finally, this work provides spectra that can be used in guiding futuremore » filter development focusing on remote alpha detection.« less

Spectral Measurements of Alpha-induced Radioluminescence in Various Gases

DOE PAGES

Brett, Jaclyn; Koehler, Katrina Elizabeth; Bischak, Michael; ...

2017-09-06

Radioluminescent emission in Ar, N 2, O 2, and dry air at P=1 atm was observed induced by 5 MeV α particles. The wavelength range with a single detector spanned 250–1100 nm, extending the range well into the UV and IR bands with a single detector. Measured spectral lines for alpha-induced luminescence were corrected for detector transmission and intensities compared to previous work. The exploration of multiple gases over a wide frequency range opens the door to security and remote sensing applications, where different environments are routinely encountered. Finally, this work provides spectra that can be used in guiding futuremore » filter development focusing on remote alpha detection.« less

Introduction: Reappraising Paul Feyerabend.

PubMed

Brown, Matthew J; Kidd, Ian James

2016-06-01

This volume is devoted to a reappraisal of the philosophy of Paul Feyerabend. It has four aims. The first is to reassess his already well-known work from the 1960s and 1970s in light of contemporary developments in the history and philosophy of science. The second is to explore themes in his neglected later work, including recently published and previously unavailable writings. The third is to assess the contributions that Feyerabend can make to contemporary debate, on topics such as perspectivism, realism, and political philosophy of science. The fourth and final aim is to reconsider Feyerabend's place within the history of philosophy of science in the light of new scholarship. Copyright © 2015 Elsevier Ltd. All rights reserved.

One- and two-center ETF-integrals of first order in relativistic calculation of NMR parameters

NASA Astrophysics Data System (ADS)

Slevinsky, R. M.; Temga, T.; Mouattamid, M.; Safouhi, H.

2010-06-01

The present work focuses on the analytical and numerical developments of first-order integrals involved in the relativistic calculation of the shielding tensor using exponential-type functions as a basis set of atomic orbitals. For the analytical development, we use the Fourier integral transformation and practical properties of spherical harmonics and the Rayleigh expansion of the plane wavefunctions. The Fourier transforms of the operators were derived in previous work and they are used for analytical development. In both the one- and two-center integrals, Cauchy's residue theorem is used in the final developments of the analytical expressions, which are shown to be accurate to machine precision.

Building America Industrialized Housing Partnership (BAIHP II)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abernethy, Bob; Chandra, Subrato; Baden, Steven

2010-11-30

This report summarizes the work conducted by the Building America Industrialized Housing Partnership (BAIHP - www.baihp.org) during the final budget period (BP5) of our contract, January 1, 2010 to November 30, 2010. Highlights from the four previous budget periods are included for context. BAIHP is led by the Florida Solar Energy Center (FSEC) of the University of Central Florida. With over 50 Industry Partners including factory and site builders, work in BP5 was performed in six tasks areas: Building America System Research Management, Documentation and Technical Support; System Performance Evaluations; Prototype House Evaluations; Initial Community Scale Evaluations; Project Closeout, Finalmore » Review of BA Communities; and Other Research Activities.« less

250 kA compact linear transformer driver for wire array z-pinch loads

NASA Astrophysics Data System (ADS)

Bott, S. C.; Haas, D. M.; Madden, R. E.; Ueda, U.; Eshaq, Y.; Collins, G., IV; Gunasekera, K.; Mariscal, D.; Peebles, J.; Beg, F. N.; Mazarakis, M.; Struve, K.; Sharpe, R.

2011-05-01

We present the application of a short rise (˜150ns) 250 kA linear transformer driver (LTD) to wire array z-pinch loads for the first time. The generator is a modification of a previous driver in which a new conical power feed provides a low inductance coupling to wire loads. Performance of the new design using both short circuit and plasma loads is presented and discussed. The final design delivers ˜200kA to a wire array load which is in good agreement with SCREAMER calculations using a simplified representative circuit. Example results demonstrate successful experiments using cylindrical, conical, and inverse wire arrays as well as previously published work on x-pinch loads.

Motion Planning in a Society of Intelligent Mobile Agents

NASA Technical Reports Server (NTRS)

Esterline, Albert C.; Shafto, Michael (Technical Monitor)

2002-01-01

The majority of the work on this grant involved formal modeling of human-computer integration. We conceptualize computer resources as a multiagent system so that these resources and human collaborators may be modeled uniformly. In previous work we had used modal for this uniform modeling, and we had developed a process-algebraic agent abstraction. In this work, we applied this abstraction (using CSP) in uniformly modeling agents and users, which allowed us to use tools for investigating CSP models. This work revealed the power of, process-algebraic handshakes in modeling face-to-face conversation. We also investigated specifications of human-computer systems in the style of algebraic specification. This involved specifying the common knowledge required for coordination and process-algebraic patterns of communication actions intended to establish the common knowledge. We investigated the conditions for agents endowed with perception to gain common knowledge and implemented a prototype neural-network system that allows agents to detect when such conditions hold. The literature on multiagent systems conceptualizes communication actions as speech acts. We implemented a prototype system that infers the deontic effects (obligations, permissions, prohibitions) of speech acts and detects violations of these effects. A prototype distributed system was developed that allows users to collaborate in moving proxy agents; it was designed to exploit handshakes and common knowledge Finally. in work carried over from a previous NASA ARC grant, about fifteen undergraduates developed and presented projects on multiagent motion planning.

NASA's James Webb Space Telescope Primary Mirror Fully Assembled

NASA Image and Video Library

2016-02-04

The 18th and final primary mirror segment is installed on what will be the biggest and most powerful space telescope ever launched. The final mirror installation Wednesday at NASA’s Goddard Space Flight Center in Greenbelt, Maryland marks an important milestone in the assembly of the agency’s James Webb Space Telescope. “Scientists and engineers have been working tirelessly to install these incredible, nearly perfect mirrors that will focus light from previously hidden realms of planetary atmospheres, star forming regions and the very beginnings of the Universe,” said John Grunsfeld, associate administrator for NASA’s Science Mission Directorate in Washington. “With the mirrors finally complete, we are one step closer to the audacious observations that will unravel the mysteries of the Universe.” Using a robotic arm reminiscent of a claw machine, the team meticulously installed all of Webb's primary mirror segments onto the telescope structure. Each of the hexagonal-shaped mirror segments measures just over 4.2 feet (1.3 meters) across -- about the size of a coffee table -- and weighs approximately 88 pounds (40 kilograms). Once in space and fully deployed, the 18 primary mirror segments will work together as one large 21.3-foot diameter (6.5-meter) mirror. Credit: NASA/Goddard/Chris Gunn Credits: NASA/Chris Gunn

Generalization of the van der Pauw relationship derived from electrostatics

NASA Astrophysics Data System (ADS)

Weiss, Jonathan D.

2011-08-01

In an earlier paper, this author, along with two others Weiss et al. (2008) [1], demonstrated that the original van der Pauw relationship could be derived from three-dimensional electrostatics, as opposed to van der Pauw's use of conformal mapping. The earlier derivation was done for a conducting material of rectangular cross section with contacts placed at the corners. Presented here is a generalization of the previous work involving a square sample and a square array of electrodes that are not confined to the corners, since this measurement configuration could be a more convenient one. As in the previous work, the effects of non-zero sample thickness and contact size have been investigated. Buehler and Thurber derived a similar relationship using an infinite series of current images on a large and thin conducting sheet to satisfy the conditions at the boundary of the sample. The results presented here agree with theirs numerically, but analytic agreement could not be shown using any of the perused mathematical literature. By simply equating the two solutions, it appears that, as a byproduct of this work, a new mathematical relationship has been uncovered. Finally, the application of this methodology to the Hall Effect is discussed.

Integrating Internal Standards into Disposable Capillary Electrophoresis Devices To Improve Quantification

PubMed Central

2017-01-01

To improve point-of-care quantification using microchip capillary electrophoresis (MCE), the chip-to-chip variabilities inherent in disposable, single-use devices must be addressed. This work proposes to integrate an internal standard (ISTD) into the microchip by adding it to the background electrolyte (BGE) instead of the sample—thus eliminating the need for additional sample manipulation, microchip redesigns, and/or system expansions required for traditional ISTD usage. Cs and Li ions were added as integrated ISTDs to the BGE, and their effects on the reproducibility of Na quantification were explored. Results were then compared to the conclusions of our previous publication which used Cs and Li as traditional ISTDs. The in-house fabricated microchips, electrophoretic protocols, and solution matrixes were kept constant, allowing the proposed method to be reliably compared to the traditional method. Using the integrated ISTDs, both Cs and Li improved the Na peak area reproducibility approximately 2-fold, to final RSD values of 2.2–4.7% (n = 900). In contrast (to previous work), Cs as a traditional ISTD resulted in final RSDs of 2.5–8.8%, while the traditional Li ISTD performed poorly with RSDs of 6.3–14.2%. These findings suggest integrated ISTDs are a viable method to improve the precision of disposable MCE devices—giving matched or superior results to the traditional method in this study while neither increasing system cost nor complexity. PMID:28192985

[Historical meanings of Santiago Ramón y Cajal's Rétine des vertébrés. Summary of his first scientific].

PubMed

Baratas Díaz, L A

1994-01-01

The retina was one of the main objects of study in the first stage of the scientific work of Ramón y Cajal. As culmination of his previous works Cajal published in 1893 in the journal La Cellule an article titled "La rétine des Vertébrés". This article on the retina is a perfect example of Cajal's ability for the systematic study of the cellular types of the nervous centers, its morphological description and its intercellular contacts, as well as for the formulation of physiological interpretations and hypothesis on the development of the neuronal prolongations. Finally some comments are made on the influence of the evolutionary thinking of Haeckel and Herbert Spencer on the work of Ramón y Cajal.

Requisites, benefits, and challenges of sustainable HIV/AIDS system-building: where theory meets practice.

PubMed

Indyk, Debbie; Rier, David A

2006-01-01

This paper is the third and final of a series that has previously presented the rationale (Rier and Indyk, this volume) and major program elements (Indyk and Rier, this volume) of an approach to link community and tertiary sociomedical providers, clients/patients, sites, and systems into an integrated response to HIV/AIDS. The primary goal has been to improve sociomedical HIV/AIDS services for a hard-to-reach inner city population. The current paper first summarizes the main advantages (e.g., greater efficiency; more realistic, effective programs with greater credibility among the community; stimulation of knowledge production and dissemination amongst players rarely formally engaged in such activities; creation of a platform useful for other applications) of this work. It then examines some of the main organizational challenges in conducting the work (involving issues such as personnel, coordination, funding, turf conflicts, sustainability). From this discussion emerge organizational requisites to conducting this work (e.g., development of key boundary-spanning figures; attention to the specific interests of potential linkage partners; translation efforts to demonstrate the value of participation; a continuous quality improvement approach featuring wide distribution of feedback in user-friendly form; flexibility, tact and patience), so that others can adapt and apply the linkage approach to manage HIV/AIDS or other problems. Finally, we explain how theory and practice have driven one another in this work.

Climate change effects on international stability : a white paper.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Murphy, Kathryn; Taylor, Mark A.; Fujii, Joy

2004-12-01

This white paper represents a summary of work intended to lay the foundation for development of a climatological/agent model of climate-induced conflict. The paper combines several loosely-coupled efforts and is the final report for a four-month late-start Laboratory Directed Research and Development (LDRD) project funded by the Advanced Concepts Group (ACG). The project involved contributions by many participants having diverse areas of expertise, with the common goal of learning how to tie together the physical and human causes and consequences of climate change. We performed a review of relevant literature on conflict arising from environmental scarcity. Rather than simply reviewingmore » the previous work, we actively collected data from the referenced sources, reproduced some of the work, and explored alternative models. We used the unfolding crisis in Darfur (western Sudan) as a case study of conflict related to or triggered by climate change, and as an exercise for developing a preliminary concept map. We also outlined a plan for implementing agents in a climate model and defined a logical progression toward the ultimate goal of running both types of models simultaneously in a two-way feedback mode, where the behavior of agents influences the climate and climate change affects the agents. Finally, we offer some ''lessons learned'' in attempting to keep a diverse and geographically dispersed group working together by using Web-based collaborative tools.« less

Cognitive predictors of a common multitasking ability: Contributions from working memory, attention control, and fluid intelligence.

PubMed

Redick, Thomas S; Shipstead, Zach; Meier, Matthew E; Montroy, Janelle J; Hicks, Kenny L; Unsworth, Nash; Kane, Michael J; Hambrick, D Zachary; Engle, Randall W

2016-11-01

Previous research has identified several cognitive abilities that are important for multitasking, but few studies have attempted to measure a general multitasking ability using a diverse set of multitasks. In the final dataset, 534 young adult subjects completed measures of working memory (WM), attention control, fluid intelligence, and multitasking. Correlations, hierarchical regression analyses, confirmatory factor analyses, structural equation models, and relative weight analyses revealed several key findings. First, although the complex tasks used to assess multitasking differed greatly in their task characteristics and demands, a coherent construct specific to multitasking ability was identified. Second, the cognitive ability predictors accounted for substantial variance in the general multitasking construct, with WM and fluid intelligence accounting for the most multitasking variance compared to attention control. Third, the magnitude of the relationships among the cognitive abilities and multitasking varied as a function of the complexity and structure of the various multitasks assessed. Finally, structural equation models based on a multifaceted model of WM indicated that attention control and capacity fully mediated the WM and multitasking relationship. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

When Moons Collide

NASA Astrophysics Data System (ADS)

Rufu, Raluca; Aharonson, Oded

2017-10-01

Impacts between two orbiting satellites is a natural consequence of Moon formation. Mergers between moonlets are especially important for the newly proposed multiple-impact hypothesis as these moonlets formed from different debris disks merge together to form the final Moon. However, this process is relevant also for the canonical giant impact, as previous work shows that multiple moonlets are formed from the same debris disk.The dynamics of impacts between two orbiting bodies is substantially different from previously heavily studied planetary-sized impacts. Firstly, the impact velocities are smaller and limited to, thus heating is limited. Secondly, both fragments have similar mass therefore, they would contribute similarly and substantially to the final satellite. Thirdly, this process can be more erosive than planetary impacts as the velocity of ejected material required to reach the mutual Hill sphere is smaller than the escape velocity, altering the merger efficiency. Previous simulations show that moonlets inherit different isotopic signatures from their primordial debris disk, depending on the parameters of the collision with the planet. We therefore, evaluate the degree of mixing in moonlet-moonlet collisions in the presence of a planetary gravitational field, using Smooth Particle Hydrodynamics (SPH). Preliminary results show that the initial thermal state of the colliding moonlets has only a minor influence on the amount of mixing, compared to the effects of velocity and impact angle over their likely ranges. For equal mass bodies in accretionary collisions, impact angular momentum enhances mixing. In the hit-and-run regime, only small amounts of material are transferred between the bodies therefore mixing is limited. Overall, these impacts can impart enough energy to melt ~15-30% of the mantle extending the magma ocean phase of the final Moon.

Zachary-Fort Lauderdale pipeline construction and conversion project: final supplement to final environmental impact statement. Docket No. CP74-192

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

This Final Supplement to the Final Environmental Impact Statement (Final Supplement) evaluates the economic, engineering, and environmental aspects of newly developed alternatives to an abandonment/conversion project proposed by Florida Gas Transmission Company (Florida Gas). It also updates the staff's previous FEIS and studies revisions to the original proposal. Wherever possible, the staff has adopted portions of its previous FEIS in lieu of reprinting portions of that analysis which require no change. 60 references, 8 figures, 35 tables.

Principle of minimal work fluctuations.

PubMed

Xiao, Gaoyang; Gong, Jiangbin

2015-08-01

Understanding and manipulating work fluctuations in microscale and nanoscale systems are of both fundamental and practical interest. For example, in considering the Jarzynski equality 〈e-βW〉=e-βΔF, a change in the fluctuations of e-βW may impact how rapidly the statistical average of e-βW converges towards the theoretical value e-βΔF, where W is the work, β is the inverse temperature, and ΔF is the free energy difference between two equilibrium states. Motivated by our previous study aiming at the suppression of work fluctuations, here we obtain a principle of minimal work fluctuations. In brief, adiabatic processes as treated in quantum and classical adiabatic theorems yield the minimal fluctuations in e-βW. In the quantum domain, if a system initially prepared at thermal equilibrium is subjected to a work protocol but isolated from a bath during the time evolution, then a quantum adiabatic process without energy level crossing (or an assisted adiabatic process reaching the same final states as in a conventional adiabatic process) yields the minimal fluctuations in e-βW, where W is the quantum work defined by two energy measurements at the beginning and at the end of the process. In the classical domain where the classical work protocol is realizable by an adiabatic process, then the classical adiabatic process also yields the minimal fluctuations in e-βW. Numerical experiments based on a Landau-Zener process confirm our theory in the quantum domain, and our theory in the classical domain explains our previous numerical findings regarding the suppression of classical work fluctuations [G. Y. Xiao and J. B. Gong, Phys. Rev. E 90, 052132 (2014)].

Generalized Robertson-Walker Space-Time Admitting Evolving Null Horizons Related to a Black Hole Event Horizon.

PubMed

Duggal, K L

2016-01-01

A new technique is used to study a family of time-dependent null horizons, called " Evolving Null Horizons " (ENHs), of generalized Robertson-Walker (GRW) space-time [Formula: see text] such that the metric [Formula: see text] satisfies a kinematic condition. This work is different from our early papers on the same issue where we used (1 + n )-splitting space-time but only some special subcases of GRW space-time have this formalism. Also, in contrast to previous work, we have proved that each member of ENHs is totally umbilical in [Formula: see text]. Finally, we show that there exists an ENH which is always a null horizon evolving into a black hole event horizon and suggest some open problems.

MRF, ELSM and STED: tools to study defects in fused silica optics

NASA Astrophysics Data System (ADS)

Catrin, R.; Taroux, D.; Cormont, P.; Maunier, C.; Neauport, J.

2013-11-01

The MegaJoule laser being constructed at the CEA near Bordeaux (France) is designed to focus more than 1 MJ of energy at 351 nm, on a millimetre scale target in the centre of an experiment chamber. The final optic assembly of this system operating at a wavelength of 351 nm is made up of large fused silica optics, working in transmission, that are used to convey and focus the laser beam. Under high fluences (i.e. more than 5 J/cm2 for 3 ns pulses), the limited lifetime of final optical assembly is a major concern for fusion scale laser facilities. Previous works have shown that surface finishing processes applied to manufacture these optical components can leave subsurface cracks (SSD), pollution or similar defects that act as initiators of the laser damage. In this work, we used epi-fluorescent light scanning microscopy (ELSM) and Stimulated Emission Depletion (STED) in confocal mode with fluorescent dye tagging to get a better knowledge of size and depth of these subsurface cracks. Magnetorheological fluid finishing technique (MRF) was also used as a tool to remove these cracks and thus assess depths measured by confocal microscopy. Subsurface cracks with a width of about 120 nm are observed up to ten micrometers below the surface.

Turbulent structures in cylindrical density currents in a rotating frame of reference

NASA Astrophysics Data System (ADS)

Salinas, Jorge S.; Cantero, Mariano I.; Dari, Enzo A.; Bonometti, Thomas

2018-06-01

Gravity currents are flows generated by the action of gravity on fluids with different densities. In some geophysical applications, modeling such flows makes it necessary to account for rotating effects, modifying the dynamics of the flow. While previous works on rotating stratified flows focused on currents of large Coriolis number, the present work focuses on flows with small Coriolis numbers (i.e. moderate-to-large Rossby numbers). In this work, cylindrical rotating gravity currents are investigated by means of highly resolved simulations. A brief analysis of the mean flow evolution to the final state is presented to provide a complete picture of the flow dynamics. The numerical results, showing the well-known oscillatory behavior of the flow (inertial waves) and a final state lens shape (geostrophic adjustment), are in good agreement with experimental observations and theoretical models. The turbulent structures in the flow are visualized and described using, among others, a stereoscopic visualization and videos as supplementary material. In particular, the structure of the lobes and clefts at the front of the current is presented in association to local turbulent structures. In rotating gravity currents, the vortices observed at the lobes front are not of hairpin type but are rather of Kelvin-Helmholtz type.

Model Assessment of the Impact on Ozone of Subsonic and Supersonic Aircraft

NASA Technical Reports Server (NTRS)

Ko, Malcolm; Weisenstein, Debra; Danilin, Michael; Scott, Courtney; Shia, Run-Lie

2000-01-01

This is the final report for work performed between June 1999 through May 2000. The work represents continuation of the previous contract which encompasses five areas: (1) continued refinements and applications of the 2-D chemistry-transport model (CTM) to assess the ozone effects from aircraft operation in the stratosphere; (2) studying the mechanisms that determine the evolution of the sulfur species in the aircraft plume and how such mechanisms affect the way aircraft sulfur emissions should be introduced into global models; (3) the development of diagnostics in the AER 3-wave interactive model to assess the importance of the dynamics feedback and zonal asymmetry in model prediction of ozone response to aircraft operation; (4) the development of a chemistry parameterization scheme in support of the global modeling initiative (GMI); and (5) providing assessment results for preparation of national and international reports which include the "Aviation and the Global Atmosphere" prepared by the Intergovernmental Panel on Climate Change, "Assessment of the effects of high-speed aircraft in the stratosphere: 1998" by NASA, and the "Model and Measurements Intercomparison II" by NASA. Part of the work was reported in the final report. We participated in the SAGE III Ozone Loss and Validation Experiment (SOLVE) campaign and we continue with our analyses of the data.

Final Scientific Report - Electromagnetic Interactions in Self-Assembled Metallo-Dielectric Biomaterials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dragnea, Bogdan G.

Achievements which resulted from previous DOE funding include: templated virus-like particle assembly thermodynamics, development of single particle photothermal absorption spectroscopy and dark- field spectroscopy instrumentation for the measurement of optical properties of virus-like nanoparticles, electromagnetic simulations of coupled nanoparticle cluster systems, virus contact mechanics, energy transfer and fluorescence quenching in multichromophore systems supported on biomolecular templates, and photo physical work on virus-aptamer systems. A current total of eight published research articles and a book chapter are acknowledging DOE support for the period 2013-2016.

Electronic response to nuclear breathing mode

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ludwig, Hendrik; Ruffini, Remo; ICRANet, University of Nice-Sophia Antipolis, 28 Av. de Valrose, 06103 Nice Cedex 2

2015-12-17

Based on our previous work on stationary oscillation modes of electrons around giant nuclei, we show how to treat a general driving force on the electron gas, such as the one generated by the breathing mode of the nucleus, by means of the spectral method. As an example we demonstrate this method for a system with Z = 10{sup 4} in β-equilibrium with the electrons compressed up to the nuclear radius. In this case the stationary modes can be obtained analytically, which allows for a very speedy numerical calculation of the final result.

Triage and Injury Severity Scoring Systems Conference Held at Washington, D.C. on 26-28 September 1983.

DTIC Science & Technology

1984-02-01

AD = 37 925 TRIAGE AND INJURY SEVERITY SCORING SYSTEMS CONFERENCE i (U) WASHINGTON HOSPITAL CENTER DC H R CHAMPION ET AL. FEB 84 DAMDI7-83-G-9529...PROCESSING SHEET PREVIOUS EDITION MAY 3E USED UNTIL CDTIC 70A STOCK IS EXHAUSTED. AD TRIAGE ALM INJURY SEVERITY SCORING SYSTEMS CONFERENCE FINAL REPORT... WORK UNIT NUMBERS The Washington Hospital Center 62734A.3MI62734A875.AG.151 Washington, D.C. 20010 I I. CONTROLLING OFFICE NAME AND ADDRESS 12. REPORT

MiniBooNE Neutrino Physics at the University of Alabama

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stancu, Ion

2007-04-27

This report summarizes the activities conducted by the UA group under the auspices of the DoE/EPSCoR grant number DE--FG02--04ER46112 since the date of the previous progress report, i.e., since November 2005. It also provides a final report of the accomplishments achieved during the entire period of this grant (February 2004 to January 2007). The grant has fully supported the work of Dr. Yong Liu (postdoctoral research assistant -- in residence at Fermilab) on the MiniBooNE reconstruction and particle identification (PID) algorithms.

Development of Technologies to Utilize Laser Plasma Radiations Sources for Radiation Effects Sciences

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davis, J F

2007-01-31

This final report will cover work performed over the period of November 11, 2005 to September 30, 2006 on the contract to develop technologies using laser sources for radiation effects sciences. The report will discuss four topic areas; the laser source experiments on the Gekko Laser at Osaka, Japan, planning for the Charge State Freeze Out experiments to be performed in calendar year 2007, a review of previous xenon gasbags on the LANL Trident laser to provide planning support to the May-June 2007 HELEN experiments.

Correlating Resolving Power, Resolution, and Collision Cross Section: Unifying Cross-Platform Assessment of Separation Efficiency in Ion Mobility Spectrometry.

PubMed

Dodds, James N; May, Jody C; McLean, John A

2017-11-21

Here we examine the relationship among resolving power (R p ), resolution (R pp ), and collision cross section (CCS) for compounds analyzed in previous ion mobility (IM) experiments representing a wide variety of instrument platforms and IM techniques. Our previous work indicated these three variables effectively describe and predict separation efficiency for drift tube ion mobility spectrometry experiments. In this work, we seek to determine if our previous findings are a general reflection of IM behavior that can be applied to various instrument platforms and mobility techniques. Results suggest IM distributions are well characterized by a Gaussian model and separation efficiency can be predicted on the basis of the empirical difference in the gas-phase CCS and a CCS-based resolving power definition (CCS/ΔCCS). Notably traveling wave (TWIMS) was found to operate at resolutions substantially higher than a single-peak resolving power suggested. When a CCS-based R p definition was utilized, TWIMS was found to operate at a resolving power between 40 and 50, confirming the previous observations by Giles and co-workers. After the separation axis (and corresponding resolving power) is converted to cross section space, it is possible to effectively predict separation behavior for all mobility techniques evaluated (i.e., uniform field, trapped ion mobility, traveling wave, cyclic, and overtone instruments) using the equations described in this work. Finally, we are able to establish for the first time that the current state-of-the-art ion mobility separations benchmark at a CCS-based resolving power of >300 that is sufficient to differentiate analyte ions with CCS differences as small as 0.5%.

Quality of life benefits of paid work activity in schizophrenia.

PubMed

Bryson, Gary; Lysaker, Paul; Bell, Morris

2002-01-01

In a study of work rehabilitation, 97 participants with schizophrenia or schizoaffective disorder were randomized into either a Pay or a No Pay condition to determine the impact of work activity and pay on rehabilitation outcomes. This report specifically investigates the relationship between work rehabilitation and quality of life (QOL) measures for people with schizophrenia. Previous reports have described improvements in symptoms and work outcomes for participants in the Pay condition. Results in this report reveal that randomization to the Pay condition improved ratings on the Heinrichs Quality of Life Scale (QLS). The improvements are found both in overall QLS and in the domain of Intrapsychic Foundations (motivation, sense of purpose, anhedonia, and empathy). For a larger sample (n = 114) we assessed the relationship between amount of participation and QLS improvement. Degree of participation was related to improvement on the QLS total and Intrapsychic Foundations domain. Finally, improvement in the Interpersonal Relations scale was associated with weeks of participation for the most consistent participants. How participation in work rehabilitation and its interaction with pay improves motivation, interpersonal relatedness, and overall quality of life is discussed.

Prevalence and Risk Factors of Colonization with Staphylococcus aureus in Healthy Pet Cats Kept in the City Households

PubMed Central

Płoneczka-Janeczko, Katarzyna; Rypuła, Krzysztof

2016-01-01

Staphylococcus aureus, especially methicillin-resistant S. aureus (MRSA), is a significant pathogen in both human medicine and veterinary medicine. The importance of pets as reservoirs of human infections is still poorly understood. This article provides detailed information of a cross-sectional study of a S. aureus colonization in clinically healthy indoor cats. The study systematically assessed a number of different anatomical locations for the S. aureus colonization and the influence of a range of potential risk factors on the value of the final S. aureus colonization rate. The incidence rates observed for cats with at least one site positive for S. aureus or MRSA were 17.5% and 6.63%, respectively. The following risk factors were identified: one or more owners working in the healthcare industry (human or veterinary); dogs being kept with the cat under investigation; treatment of the cat under investigation with antibiotics or chemotherapeutics during the previous year. In conclusion, this study revealed a higher prevalence of MRSA than what has previously been reported in healthy pets. A combination of anatomical locations from which the samples were collected had a major influence on the final value of the S. aureus colonization rate. PMID:27766257

Nuclear Data Sheets for A=217

DOE PAGES

Kondev, F. G.; McCutchan, E. A.; Singh, B.; ...

2018-01-17

The evaluated spectroscopic data are presented in this paper for 12 known nuclides with A=217 (Tl, Pb, Bi, Po, At, Rn, Fr, Ra, Ac, Th, Pa, U). For 217Tl, 217Pb, 217Pa, and 217U nuclei, only information on the ground state is available. Levels in 217Bi are known only from isomer decay following fragmentation reaction and those in 217At and 217Rn only from the α decay of 221Fr and 221Ra, respectively. High spin levels in 217Ra are mainly from 1987SuZY and 2011MuZZ which are a lab report and thesis, respectively. Due to differences between these studies, further experimental study is neededmore » to firmly establish the level scheme. This evaluation was carried out as part of a joint IAEA-ICTP workshop for Nuclear Structure and Decay Data, organized and hosted by the IAEA, Vienna and ICTP, Trieste, Aug 22 to Sept 2 2016. The evaluation work was coordinated by E.A. McCutchan (BNL). Finally, this work supersedes the previous previous A=217 evaluation (2003Ak06) by Y.A. Akovali.« less

Nuclear Data Sheets for A=217

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kondev, F. G.; McCutchan, E. A.; Singh, B.

The evaluated spectroscopic data are presented in this paper for 12 known nuclides with A=217 (Tl, Pb, Bi, Po, At, Rn, Fr, Ra, Ac, Th, Pa, U). For 217Tl, 217Pb, 217Pa, and 217U nuclei, only information on the ground state is available. Levels in 217Bi are known only from isomer decay following fragmentation reaction and those in 217At and 217Rn only from the α decay of 221Fr and 221Ra, respectively. High spin levels in 217Ra are mainly from 1987SuZY and 2011MuZZ which are a lab report and thesis, respectively. Due to differences between these studies, further experimental study is neededmore » to firmly establish the level scheme. This evaluation was carried out as part of a joint IAEA-ICTP workshop for Nuclear Structure and Decay Data, organized and hosted by the IAEA, Vienna and ICTP, Trieste, Aug 22 to Sept 2 2016. The evaluation work was coordinated by E.A. McCutchan (BNL). Finally, this work supersedes the previous previous A=217 evaluation (2003Ak06) by Y.A. Akovali.« less

MALDI-MS analysis and imaging of small molecule metabolites with 1,5-diaminonaphthalene (DAN).

PubMed

Korte, Andrew R; Lee, Young Jin

2014-08-01

1,5-Diaminonaphthalene (DAN) has previously been reported as an effective matrix for matrix-assisted laser desorption ionization-mass spectrometry of phospholipids. In the current work, we investigate the use of DAN as a matrix for small metabolite analysis in negative ion mode. DAN was found to provide superior ionization to the compared matrices for MW < ~400 Da; however, 9-aminoacridine (9-AA) was found to be superior for a uridine diphosphate standard (MW 566 Da). DAN was also found to provide a more representative profile of a natural phospholipid mixture than 9-AA. Finally, DAN and 9-AA were applied for imaging of metabolites directly from corn leaf sections. Published 2014. This article is a U.S. Government work and is in the public domain in the USA. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.

Efficient reinforcement learning of a reservoir network model of parametric working memory achieved with a cluster population winner-take-all readout mechanism.

PubMed

Cheng, Zhenbo; Deng, Zhidong; Hu, Xiaolin; Zhang, Bo; Yang, Tianming

2015-12-01

The brain often has to make decisions based on information stored in working memory, but the neural circuitry underlying working memory is not fully understood. Many theoretical efforts have been focused on modeling the persistent delay period activity in the prefrontal areas that is believed to represent working memory. Recent experiments reveal that the delay period activity in the prefrontal cortex is neither static nor homogeneous as previously assumed. Models based on reservoir networks have been proposed to model such a dynamical activity pattern. The connections between neurons within a reservoir are random and do not require explicit tuning. Information storage does not depend on the stable states of the network. However, it is not clear how the encoded information can be retrieved for decision making with a biologically realistic algorithm. We therefore built a reservoir-based neural network to model the neuronal responses of the prefrontal cortex in a somatosensory delayed discrimination task. We first illustrate that the neurons in the reservoir exhibit a heterogeneous and dynamical delay period activity observed in previous experiments. Then we show that a cluster population circuit decodes the information from the reservoir with a winner-take-all mechanism and contributes to the decision making. Finally, we show that the model achieves a good performance rapidly by shaping only the readout with reinforcement learning. Our model reproduces important features of previous behavior and neurophysiology data. We illustrate for the first time how task-specific information stored in a reservoir network can be retrieved with a biologically plausible reinforcement learning training scheme. Copyright © 2015 the American Physiological Society.

[Nurses' participation in the development of a multidisciplinary team for chronic and terminal patients].

PubMed

Shimizu, H E; Guitierrez, B A

1997-08-01

Since long ago the nurse has become more concerned about the delivery of care for patients with chronic and degeneratives diseases. Nevertheless, the accomplishment of this task is not an easy one. Moreover, when the patient reaches the final stage. Usually this patient experiences emotional and physical alteration. The family is deeply involved in this process and generally they seek nurses help because they are the closest ones to the patient and his/her family. When the patient go trough this dramatic acute change in health condition or in face of chronic degenerative or final stage disease is made, the relationship with the family becomes more difficult demanding nursing intervention. The objective of this study is to report the experience of nurse's participation in the implantation and development of multidisciplinary group for treatment of chronical and final stage patients. This group has been working for two years and has had good results. This group has worked treatment schemes for treatment used by all members of multidisciplinary team. From previous experiences, we knew that there is always a discrepancy between the information given by professional and friends and relatives ones. Which could increase fear and anxiety the reassurance given by the health team, a fair distribution of tasks and the information delivery to the patient proved to be successful.

Stress, burnout and doctors' attitudes to work are determined by personality and learning style: a twelve year longitudinal study of UK medical graduates.

PubMed

McManus, I C; Keeling, A; Paice, E

2004-08-18

The study investigated the extent to which approaches to work, workplace climate, stress, burnout and satisfaction with medicine as a career in doctors aged about thirty are predicted by measures of learning style and personality measured five to twelve years earlier when the doctors were applicants to medical school or were medical students. Prospective study of a large cohort of doctors. The participants were first studied when they applied to any of five UK medical schools in 1990. Postal questionnaires were sent to all doctors with a traceable address on the current or a previous Medical Register. The current questionnaire included measures of Approaches to Work, Workplace Climate, stress (General Health Questionnaire), burnout (Maslach Burnout Inventory), and satisfaction with medicine as a career and personality (Big Five). Previous questionnaires had included measures of learning style (Study Process Questionnaire) and personality. Doctors' approaches to work were predicted by study habits and learning styles, both at application to medical school and in the final year. How doctors perceive their workplace climate and workload is predicted both by approaches to work and by measures of stress, burnout and satisfaction with medicine. These characteristics are partially predicted by trait measures of personality taken five years earlier. Stress, burnout and satisfaction also correlate with trait measures of personality taken five years earlier. Differences in approach to work and perceived workplace climate seem mainly to reflect stable, long-term individual differences in doctors themselves, reflected in measures of personality and learning style.

Stress, burnout and doctors' attitudes to work are determined by personality and learning style: A twelve year longitudinal study of UK medical graduates

PubMed Central

McManus, IC; Keeling, A; Paice, E

2004-01-01

Background The study investigated the extent to which approaches to work, workplace climate, stress, burnout and satisfaction with medicine as a career in doctors aged about thirty are predicted by measures of learning style and personality measured five to twelve years earlier when the doctors were applicants to medical school or were medical students. Methods Prospective study of a large cohort of doctors. The participants were first studied when they applied to any of five UK medical schools in 1990. Postal questionnaires were sent to all doctors with a traceable address on the current or a previous Medical Register. The current questionnaire included measures of Approaches to Work, Workplace Climate, stress (General Health Questionnaire), burnout (Maslach Burnout Inventory), and satisfaction with medicine as a career and personality (Big Five). Previous questionnaires had included measures of learning style (Study Process Questionnaire) and personality. Results Doctors' approaches to work were predicted by study habits and learning styles, both at application to medical school and in the final year. How doctors perceive their workplace climate and workload is predicted both by approaches to work and by measures of stress, burnout and satisfaction with medicine. These characteristics are partially predicted by trait measures of personality taken five years earlier. Stress, burnout and satisfaction also correlate with trait measures of personality taken five years earlier. Conclusions Differences in approach to work and perceived workplace climate seem mainly to reflect stable, long-term individual differences in doctors themselves, reflected in measures of personality and learning style. PMID:15317650

Light flavon signals at electron-photon colliders

NASA Astrophysics Data System (ADS)

Muramatsu, Yu; Nomura, Takaaki; Shimizu, Yusuke; Yokoya, Hiroshi

2018-01-01

Flavor symmetries are useful to realize fermion flavor structures in the standard model (SM). In particular, the discrete A4 symmetry is used to realize lepton flavor structures, and some scalars—called flavons—are introduced to break this symmetry. In many models, flavons are assumed to be much heavier than the electroweak scale. However, our previous work showed that a flavon mass around 100 GeV is allowed by experimental constraints in the A4 symmetric model with a residual Z3 symmetry. In this paper, we discuss collider searches for such a light flavon φT. We find that electron-photon collisions at the International Linear Collider have advantages for searching for these signals. In electron-photon collisions, flavons are produced as e-γ →l-φT and decay into two charged leptons. Then, we analyze signals of the flavor-conserving final state τ+τ-e- and the flavor-violating final states τ+μ-μ- and μ+τ-τ- by carrying out numerical simulations. For the former final state, SM background can be strongly suppressed by imposing cuts on the invariant masses of final-state leptons. For the latter final states, SM background is extremely small, because in the SM there are no such flavor-violating final states. We then find that sufficient discovery significance can be obtained, even if flavons are heavier than the lower limits from flavor physics.

No functional role of attention-based rehearsal in maintenance of spatial working memory representations.

PubMed

Belopolsky, Artem V; Theeuwes, Jan

2009-10-01

The present study systematically examined the role of attention in maintenance of spatial representations in working memory as proposed by the attention-based rehearsal hypothesis [Awh, E., Jonides, J., & Reuter-Lorenz, P. A. (1998). Rehearsal in spatial working memory. Journal of Experimental Psychology--Human Perception and Performance, 24(3), 780-790]. Three main issues were examined. First, Experiments 1-3 demonstrated that inhibition and not facilitation of visual processing is often observed at the memorized location during the retention interval. This inhibition was caused by keeping a location in memory and not by the exogenous nature of the memory cue. Second, Experiment 4 showed that inhibition of the memorized location does not lead to any significant impairment in memory accuracy. Finally, Experiment 5 connected current results to the previous findings and demonstrated facilitation of processing at the memorized location. Importantly, facilitation of processing did not lead to more accurate memory performance. The present results challenge the functional role of attention in maintenance of spatial working memory representations.

Final Report: Subcontract B623868 Algebraic Multigrid solvers for coupled PDE systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brannick, J.

The Pennsylvania State University (“Subcontractor”) continued to work on the design of algebraic multigrid solvers for coupled systems of partial differential equations (PDEs) arising in numerical modeling of various applications, with a main focus on solving the Dirac equation arising in Quantum Chromodynamics (QCD). The goal of the proposed work was to develop combined geometric and algebraic multilevel solvers that are robust and lend themselves to efficient implementation on massively parallel heterogeneous computers for these QCD systems. The research in these areas built on previous works, focusing on the following three topics: (1) the development of parallel full-multigrid (PFMG) andmore » non-Galerkin coarsening techniques in this frame work for solving the Wilson Dirac system; (2) the use of these same Wilson MG solvers for preconditioning the Overlap and Domain Wall formulations of the Dirac equation; and (3) the design and analysis of algebraic coarsening algorithms for coupled PDE systems including Stokes equation, Maxwell equation and linear elasticity.« less

Confident failures: Lapses of working memory reveal a metacognitive blind spot.

PubMed

Adam, Kirsten C S; Vogel, Edward K

2017-07-01

Working memory performance fluctuates dramatically from trial to trial. On many trials, performance is no better than chance. Here, we assessed participants' awareness of working memory failures. We used a whole-report visual working memory task to quantify both trial-by-trial performance and trial-by-trial subjective ratings of inattention to the task. In Experiment 1 (N = 41), participants were probed for task-unrelated thoughts immediately following 20% of trials. In Experiment 2 (N = 30), participants gave a rating of their attentional state following 25% of trials. Finally, in Experiments 3a (N = 44) and 3b (N = 34), participants reported confidence of every response using a simple mouse-click judgment. Attention-state ratings and off-task thoughts predicted the number of items correctly identified on each trial, replicating previous findings that subjective measures of attention state predict working memory performance. However, participants correctly identified failures on only around 28% of failure trials. Across experiments, participants' metacognitive judgments reliably predicted variation in working memory performance but consistently and severely underestimated the extent of failures. Further, individual differences in metacognitive accuracy correlated with overall working memory performance, suggesting that metacognitive monitoring may be key to working memory success.

Development and evaluation of an office ergonomic risk checklist: ROSA--rapid office strain assessment.

PubMed

Sonne, Michael; Villalta, Dino L; Andrews, David M

2012-01-01

The Rapid Office Strain Assessment (ROSA) was designed to quickly quantify risks associated with computer work and to establish an action level for change based on reports of worker discomfort. Computer use risk factors were identified in previous research and standards on office design for the chair, monitor, telephone, keyboard and mouse. The risk factors were diagrammed and coded as increasing scores from 1 to 3. ROSA final scores ranged in magnitude from 1 to 10, with each successive score representing an increased presence of risk factors. Total body discomfort and ROSA final scores for 72 office workstations were significantly correlated (R = 0.384). ROSA final scores exhibited high inter- and intra-observer reliability (ICCs of 0.88 and 0.91, respectively). Mean discomfort increased with increasing ROSA scores, with a significant difference occurring between scores of 3 and 5 (out of 10). A ROSA final score of 5 might therefore be useful as an action level indicating when immediate change is necessary. ROSA proved to be an effective and reliable method for identifying computer use risk factors related to discomfort. Copyright © 2011 Elsevier Ltd and The Ergonomics Society. All rights reserved.

A Kalman Filtering Perspective for Multiatlas Segmentation*

PubMed Central

Gao, Yi; Zhu, Liangjia; Cates, Joshua; MacLeod, Rob S.; Bouix, Sylvain; Tannenbaum, Allen

2016-01-01

In multiatlas segmentation, one typically registers several atlases to the novel image, and their respective segmented label images are transformed and fused to form the final segmentation. In this work, we provide a new dynamical system perspective for multiatlas segmentation, inspired by the following fact: The transformation that aligns the current atlas to the novel image can be not only computed by direct registration but also inferred from the transformation that aligns the previous atlas to the image together with the transformation between the two atlases. This process is similar to the global positioning system on a vehicle, which gets position by inquiring from the satellite and by employing the previous location and velocity—neither answer in isolation being perfect. To solve this problem, a dynamical system scheme is crucial to combine the two pieces of information; for example, a Kalman filtering scheme is used. Accordingly, in this work, a Kalman multiatlas segmentation is proposed to stabilize the global/affine registration step. The contributions of this work are twofold. First, it provides a new dynamical systematic perspective for standard independent multiatlas registrations, and it is solved by Kalman filtering. Second, with very little extra computation, it can be combined with most existing multiatlas segmentation schemes for better registration/segmentation accuracy. PMID:26807162

Generalized Robertson-Walker Space-Time Admitting Evolving Null Horizons Related to a Black Hole Event Horizon

PubMed Central

2016-01-01

A new technique is used to study a family of time-dependent null horizons, called “Evolving Null Horizons” (ENHs), of generalized Robertson-Walker (GRW) space-time (M¯,g¯) such that the metric g¯ satisfies a kinematic condition. This work is different from our early papers on the same issue where we used (1 + n)-splitting space-time but only some special subcases of GRW space-time have this formalism. Also, in contrast to previous work, we have proved that each member of ENHs is totally umbilical in (M¯,g¯). Finally, we show that there exists an ENH which is always a null horizon evolving into a black hole event horizon and suggest some open problems. PMID:27722202

Jeffrey fluid effect on free convective over a vertically inclined plate with magnetic field: A numerical approach

NASA Astrophysics Data System (ADS)

Rao, J. Anand; Raju, R. Srinivasa; Bucchaiah, C. D.

2018-05-01

In this work, the effect of magnetohydrodynamic natural or free convective of an incompressible, viscous and electrically conducting non-newtonian Jeffrey fluid over a semi-infinite vertically inclined permeable moving plate embedded in a porous medium in the presence of heat absorption, heat and mass transfer. By using non-dimensional quantities, the fundamental governing non-linear partial differential equations are transformed into linear partial differential equations and these equations together with associated boundary conditions are solved numerically by using versatile, extensively validated, variational finite element method. The sway of important key parameters on hydrodynamic, thermal and concentration boundary layers are examined in detail and the results are shown graphically. Finally the results are compared with the works published previously and found to be excellent agreement.

Outer synchronization of complex networks with internal delay and coupling delay via aperiodically intermittent pinning control

NASA Astrophysics Data System (ADS)

Zhang, Chuan; Wang, Xingyuan; Wang, Chunpeng; Xia, Zhiqiu

This paper concerns the outer synchronization problem between two complex delayed networks via the method of aperiodically intermittent pinning control. Apart from previous works, internal delay and coupling delay are both involved in this model, and the designed intermittent controllers can be aperiodic. The main work in this paper can be summarized as follows: First, two cases of aperiodically intermittent control with constant gain and adaptive gain are implemented, respectively. The intermittent control and pinning control are combined to reduce consumptions further. Then, based on the Lyapunov stability theory, synchronization protocols are given by strict derivation. Especially, the designed controllers are indeed simple and valid in application of theory to practice. Finally, numerical examples put the proposed control methods to the test.

Development of spatial preferences for counting and picture naming.

PubMed

Knudsen, Birgit; Fischer, Martin H; Aschersleben, Gisa

2015-11-01

The direction of object enumeration reflects children's enculturation but previous work on the development of such spatial preferences has been inconsistent. Therefore, we documented directional preferences in finger counting, object counting, and picture naming for children (4 groups from 3 to 6 years, N = 104) and adults (N = 56). We found a right-side preference for finger counting in 3- to 6-year-olds and a left-side preference for counting objects and naming pictures by 6 years of age. Children were consistent in their special preferences when comparing object counting and picture naming, but not in other task pairings. Finally, spatial preferences were not related to cardinality comprehension. These results, together with other recent work, suggest a gradual development of spatial-numerical associations from early non-directional mappings into culturally constrained directional mappings.

Percolation of binary disk systems: Modeling and theory

DOE PAGES

Meeks, Kelsey; Tencer, John; Pantoya, Michelle L.

2017-01-12

The dispersion and connectivity of particles with a high degree of polydispersity is relevant to problems involving composite material properties and reaction decomposition prediction and has been the subject of much study in the literature. This paper utilizes Monte Carlo models to predict percolation thresholds for a two-dimensional systems containing disks of two different radii. Monte Carlo simulations and spanning probability are used to extend prior models into regions of higher polydispersity than those previously considered. A correlation to predict the percolation threshold for binary disk systems is proposed based on the extended dataset presented in this work and comparedmore » to previously published correlations. Finally, a set of boundary conditions necessary for a good fit is presented, and a condition for maximizing percolation threshold for binary disk systems is suggested.« less

A gyrokinetic one-dimensional scrape-off layer model of an edge-localized mode heat pulse

DOE PAGES

Shi, E. L.; Hakim, A. H.; Hammett, G. W.

2015-02-03

An electrostatic gyrokinetic-based model is applied to simulate parallel plasma transport in the scrape-off layer to a divertor plate. We focus on a test problem that has been studied previously, using parameters chosen to model a heat pulse driven by an edge-localized mode in JET. Previous work has used direct particle-in-cellequations with full dynamics, or Vlasov or fluid equations with only parallel dynamics. With the use of the gyrokinetic quasineutrality equation and logical sheathboundary conditions, spatial and temporal resolution requirements are no longer set by the electron Debye length and plasma frequency, respectively. Finally, this test problem also helps illustratemore » some of the physics contained in the Hamiltonian form of the gyrokineticequations and some of the numerical challenges in developing an edge gyrokinetic code.« less

What works with worked examples: Extending self-explanation and analogical comparison to synthesis problems

NASA Astrophysics Data System (ADS)

Badeau, Ryan; White, Daniel R.; Ibrahim, Bashirah; Ding, Lin; Heckler, Andrew F.

2017-12-01

The ability to solve physics problems that require multiple concepts from across the physics curriculum—"synthesis" problems—is often a goal of physics instruction. Three experiments were designed to evaluate the effectiveness of two instructional methods employing worked examples on student performance with synthesis problems; these instructional techniques, analogical comparison and self-explanation, have previously been studied primarily in the context of single-concept problems. Across three experiments with students from introductory calculus-based physics courses, both self-explanation and certain kinds of analogical comparison of worked examples significantly improved student performance on a target synthesis problem, with distinct improvements in recognition of the relevant concepts. More specifically, analogical comparison significantly improved student performance when the comparisons were invoked between worked synthesis examples. In contrast, similar comparisons between corresponding pairs of worked single-concept examples did not significantly improve performance. On a more complicated synthesis problem, self-explanation was significantly more effective than analogical comparison, potentially due to differences in how successfully students encoded the full structure of the worked examples. Finally, we find that the two techniques can be combined for additional benefit, with the trade-off of slightly more time on task.

Development of a Human Brain Diffusion Tensor Template

PubMed Central

Peng, Huiling; Orlichenko, Anton; Dawe, Robert J.; Agam, Gady; Zhang, Shengwei; Arfanakis, Konstantinos

2009-01-01

The development of a brain template for diffusion tensor imaging (DTI) is crucial for comparisons of neuronal structural integrity and brain connectivity across populations, as well as for the development of a white matter atlas. Previous efforts to produce a DTI brain template have been compromised by factors related to image quality, the effectiveness of the image registration approach, the appropriateness of subject inclusion criteria, the completeness and accuracy of the information summarized in the final template. The purpose of this work was to develop a DTI human brain template using techniques that address the shortcomings of previous efforts. Therefore, data containing minimal artifacts were first obtained on 67 healthy human subjects selected from an age-group with relatively similar diffusion characteristics (20–40 years of age), using an appropriate DTI acquisition protocol. Non-linear image registration based on mean diffusion-weighted and fractional anisotropy images was employed. DTI brain templates containing median and mean tensors were produced in ICBM-152 space and made publicly available. The resulting set of DTI templates is characterized by higher image sharpness, provides the ability to distinguish smaller white matter fiber structures, contains fewer image artifacts, than previously developed templates, and to our knowledge, is one of only two templates produced based on a relatively large number of subjects. Furthermore, median tensors were shown to better preserve the diffusion characteristics at the group level than mean tensors. Finally, white matter fiber tractography was applied on the template and several fiber-bundles were traced. PMID:19341801

Development of a human brain diffusion tensor template.

PubMed

Peng, Huiling; Orlichenko, Anton; Dawe, Robert J; Agam, Gady; Zhang, Shengwei; Arfanakis, Konstantinos

2009-07-15

The development of a brain template for diffusion tensor imaging (DTI) is crucial for comparisons of neuronal structural integrity and brain connectivity across populations, as well as for the development of a white matter atlas. Previous efforts to produce a DTI brain template have been compromised by factors related to image quality, the effectiveness of the image registration approach, the appropriateness of subject inclusion criteria, and the completeness and accuracy of the information summarized in the final template. The purpose of this work was to develop a DTI human brain template using techniques that address the shortcomings of previous efforts. Therefore, data containing minimal artifacts were first obtained on 67 healthy human subjects selected from an age-group with relatively similar diffusion characteristics (20-40 years of age), using an appropriate DTI acquisition protocol. Non-linear image registration based on mean diffusion-weighted and fractional anisotropy images was employed. DTI brain templates containing median and mean tensors were produced in ICBM-152 space and made publicly available. The resulting set of DTI templates is characterized by higher image sharpness, provides the ability to distinguish smaller white matter fiber structures, contains fewer image artifacts, than previously developed templates, and to our knowledge, is one of only two templates produced based on a relatively large number of subjects. Furthermore, median tensors were shown to better preserve the diffusion characteristics at the group level than mean tensors. Finally, white matter fiber tractography was applied on the template and several fiber-bundles were traced.

Parallelization of Rocket Engine Simulator Software (P.R.E.S.S.)

NASA Technical Reports Server (NTRS)

Cezzar, Ruknet

1999-01-01

Parallelization of Rocket Engine System Software (PRESS) project is part of a collaborative effort with Southern University at Baton Rouge (SUBR), University of West Florida (UWF), and Jackson State University (JSU). The project has started on October 19, 1995, and after a three-year period corresponding to project phases and fiscal-year funding by NASA Lewis Research Center (now Glenn Research Center), has ended on October 18, 1998. The one-year no-cost extension period was granted on June 7, 1998, until October 19, 1999. The aim of this one year no-cost extension period was to carry out further research to complete the work and lay the groundwork for subsequent research in the area of aerospace engine design optimization software tools. The previous progress for the research has been reported in great detail in respective interim and final research progress reports, seven of them, in all. While the purpose of this report is to be a final summary and an valuative view of the entire work since the first year funding, the following is a quick recap of the most important sections of the interim report dated April 30, 1999.

Image superresolution of cytology images using wavelet based patch search

NASA Astrophysics Data System (ADS)

Vargas, Carlos; García-Arteaga, Juan D.; Romero, Eduardo

2015-01-01

Telecytology is a new research area that holds the potential of significantly reducing the number of deaths due to cervical cancer in developing countries. This work presents a novel super-resolution technique that couples high and low frequency information in order to reduce the bandwidth consumption of cervical image transmission. The proposed approach starts by decomposing into wavelets the high resolution images and transmitting only the lower frequency coefficients. The transmitted coefficients are used to reconstruct an image of the original size. Additional details are added by iteratively replacing patches of the wavelet reconstructed image with equivalent high resolution patches from a previously acquired image database. Finally, the original transmitted low frequency coefficients are used to correct the final image. Results show a higher signal to noise ratio in the proposed method over simply discarding high frequency wavelet coefficients or replacing directly down-sampled patches from the image-database.

Application of the fuzzy topsis multi-attribute decision making method to determine scholarship recipients

NASA Astrophysics Data System (ADS)

Irvanizam, I.

2018-03-01

Some scholarships have been routinely offered by Ministry of Research, Technology and Higher Education of the Republic of Indonesia for students at Syiah Kuala University. In reality, the scholarship selection process is becoming subjective and highly complex problem. Multi-Attribute Decision Making (MADM) techniques can be a solution in order to solve scholarship selection problem. In this study, we demonstrated the application of a fuzzy TOPSIS as an MADM technique by using a numerical example in order to calculate a triangular fuzzy number for the fuzzy data onto a normalized weight. We then use this normalized value to construct the normalized fuzzy decision matrix. We finally use the fuzzy TOPSIS to rank alternatives in descending order based on the relative closeness to the ideal solution. The result in terms of final ranking shows slightly different from the previous work.

The Modulus of Rupture from a Mathematical Point of View

NASA Astrophysics Data System (ADS)

Quintela, P.; Sánchez, M. T.

2007-04-01

The goal of this work is to present a complete mathematical study about the three-point bending experiments and the modulus of rupture of brittle materials. We will present the mathematical model associated to three-point bending experiments and we will use the asymptotic expansion method to obtain a new formula to calculate the modulus of rupture. We will compare the modulus of rupture of porcelain obtained with the previous formula with that obtained by using the classic theoretical formula. Finally, we will also present one and three-dimensional numerical simulations to compute the modulus of rupture.

Wind energy converter with high-speed vertical axis rotor and straight rotor blades

NASA Astrophysics Data System (ADS)

Zelck, G.

1982-11-01

Complete documents for a wind energy converter with a vertical axis rotor and straight blades (H-rotor) were developed. The 2 blade rotor with rigid and rectangular air foils in wooden construction reaches the nominal output of 75 KVA from 11,4 m/sec. wind velocity onwards. The development activities are supported by wind tunnel and component tests. The final design selected was based upon previous development work. Trade offs show that the design is more advantageous compared to other designs. The use of wood as a material for the rotary and horizontal blade supports gives positive result.

Towards an analytical framework for tailoring supercontinuum generation.

PubMed

Castelló-Lurbe, David; Vermeulen, Nathalie; Silvestre, Enrique

2016-11-14

A fully analytical toolbox for supercontinuum generation relying on scenarios without pulse splitting is presented. Furthermore, starting from the new insights provided by this formalism about the physical nature of direct and cascaded dispersive wave emission, a unified description of this radiation in both normal and anomalous dispersion regimes is derived. Previously unidentified physics of broadband spectra reported in earlier works is successfully explained on this basis. Finally, a foundry-compatible few-millimeters-long silicon waveguide allowing octave-spanning supercontinuum generation pumped at telecom wavelengths in the normal dispersion regime is designed, hence showcasing the potential of this new analytical approach.

Parameter-tolerant design of high contrast gratings

NASA Astrophysics Data System (ADS)

Chevallier, Christyves; Fressengeas, Nicolas; Jacquet, Joel; Almuneau, Guilhem; Laaroussi, Youness; Gauthier-Lafaye, Olivier; Cerutti, Laurent; Genty, Frédéric

2015-02-01

This work is devoted to the design of high contrast grating mirrors taking into account the technological constraints and tolerance of fabrication. First, a global optimization algorithm has been combined to a numerical analysis of grating structures (RCWA) to automatically design HCG mirrors. Then, the tolerances of the grating dimensions have been precisely studied to develop a robust optimization algorithm with which high contrast gratings, exhibiting not only a high efficiency but also large tolerance values, could be designed. Finally, several structures integrating previously designed HCGs has been simulated to validate and illustrate the interest of such gratings.

Inter-Individual Variability in Human Response to Low-Dose Ionizing Radiation, Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rocke, David

2016-08-01

In order to investigate inter-individual variability in response to low-dose ionizing radiation, we are working with three models, 1) in-vivo irradiated human skin, for which we have a realistic model, but with few subjects, all from a previous project, 2) ex-vivo irradiated human skin, for which we also have a realistic model, though with the limitations involved in keeping skin pieces alive in media, and 3) MatTek EpiDermFT skin plugs, which provides a more realistic model than cell lines, which is more controllable than human samples.

Bird collections in the United States and Canada: Addenda and corrigenda

USGS Publications Warehouse

Clench, M.H.; Banks, R.C.; Barlow, J.C.

1976-01-01

Since publication of our report on the avian collections in the United States and Canada (Banks, Clench, and Barlow 1973, Auk 90: 136- 170) several changes and additions have come to our attention. In some cases, recent curatorial work has resulted in more accurate counts to replace previous estimates. Other collections have grown markedly in the last few years. Some important private or institutional collections have been transferred to other jurisdictions. Finally, we have received a few completely new reports from collections that were unknown to us or that were unresponsive to our original requests for information.

Further efforts in optimizing nonlinear optical molecules

NASA Astrophysics Data System (ADS)

Dirk, Carl W.; Caballero, Noel; Tan, Alarice; Kuzyk, Mark G.; Cheng, Lap-Tak A.; Katz, Howard E.; Shilling, Marcia; King, Lori A.

1993-02-01

We summarize some of our past work in the field on optimizing molecules for second order and third order nonlinear optical applications. We also present some previously unpublished results suggesting a particular optimization of the popular cyano- and nitrovinyl acceptor groups. In addition we provide some new quadratic electro-optic results which serve to further verify our choice of a restricted three-level model suitable for optimizing third order nonlinearities in molecules. Finally we present a new squarylium dye with a large third order optical nonlinearity (-9.5 X 10-34 cm7/esu2; EFISH (gamma) at 1906 nm).

Clinicians' views of factors of importance for improving the rate of VBAC (vaginal birth after caesarean section): a qualitative study from countries with high VBAC rates.

PubMed

Lundgren, Ingela; van Limbeek, Evelien; Vehvilainen-Julkunen, Katri; Nilsson, Christina

2015-08-28

The most common reason for caesarean section (CS) is repeat CS following previous CS. Vaginal birth after caesarean section (VBAC) rates vary widely in different healthcare settings and countries. Obtaining deeper knowledge of clinicians' views on VBAC can help in understanding the factors of importance for increasing VBAC rates. Interview studies with clinicians and women in three countries with high VBAC rates (Finland, Sweden and the Netherlands) and three countries with low VBAC rates (Ireland, Italy and Germany) are part of 'OptiBIRTH', an ongoing research project. The study reported here is based on interviews in high VBAC countries. The aim of the study was to investigate the views of clinicians working in countries with high VBAC rates on factors of importance for improving VBAC rates. Individual (face-to-face or telephone) interviews and focus group interviews with clinicians (in different maternity care settings) in three countries with high VBAC rates were conducted during 2012-2013. In total, 44 clinicians participated: 26 midwives and 18 obstetricians. Five central questions about VBAC were used and interviews were analysed using content analysis. The analysis was performed in each country in the native language and then translated into English. All data were then analysed together and final categories were validated in each country. The findings are presented in four main categories with subcategories. First, a common approach is needed, including: feeling confident with VBAC, considering VBAC as the first alternative, communicating well, working in a team, working in accordance with a model and making agreements with the woman. Second, obstetricians need to make the final decision on the mode of delivery while involving women in counselling towards VBAC. Third, a woman who has a previous CS has a similar need for support as other labouring women, but with some extra precautions and additional recommendations for her care. Finally, clinicians should help strengthen women's trust in VBAC, including building their trust in giving birth vaginally, recognising that giving birth naturally is an empowering experience for women, alleviating fear and offering extra visits to discuss the previous CS, and joining with the woman in a dialogue while leaving the decision about the mode of birth open. This study shows that, according to midwives and obstetricians from countries with high VBAC rates, the important factors for improving the VBAC rate are related to the structure of the maternity care system in the country, to the cooperation between midwives and obstetricians, and to the care offered during pregnancy and birth. More research on clinicians' perspectives is needed from countries with low, as well as high, VBAC rates.

A hybrid finite element-boundary integral for the analysis of cavity-backed antennas of arbitrary shape

NASA Technical Reports Server (NTRS)

Gong, Jian; Volakis, John L.; Woo, A. C.; Wang, H. T. G.

1993-01-01

This is the final report on this project which was concerned with the analysis of cavity-backed antennas and more specifically spiral antennas. The project was a continuation of a previous analysis, which employed rectangular brick elements, and was, thus, restricted to planar rectangular patch antennas. A total of five reports were submitted under this project and we expect that at least four journal papers will result from the research described in these reports. The abstracts of the four previous reports are included. The first of the reports (028918-1-T) is over 75 pages and describes the general formulation using tetrahedral elements and the computer program. Report 028918-2-T was written after the completion of the computer program and reviews the capability of the analysis and associated software for planar circular rectangular patches and for a rectangular planar spiral. Measurements were also done at the University of Michigan and at Mission Research Corp. for the purpose of validating the software. We are pleased to acknowledge a partial support from Mission Research Corp. in carrying out the work described in this report. The third report (028918-3-T) describes the formulation and partial validation (using 2D data) for patch antennas on a circular platform. The 3D validation and development of the formulation for patch antennas on circular platforms is still in progress. The fourth report (028918-4-T) is basically an invited journal paper which will appear in the 'J. Electromagnetic Waves and Applications' in early 1994. It describes the application of the finite element method in electromagnetics and is primarily based on our work here at U-M. This final report describes the culmination of our efforts in characterizing complex cavity-backed antennas on planar platforms. The report describes for the first time the analysis of non-planar spirals and non-rectangular slot antennas as well as traditional planar patch antennas. The comparisons between measurements and calculations are truly impressive. Another unique aspect of this work is the incorporation of the FFT as part of the BiCG solver by overlaying a structured triangular mesh over the unstructured mesh. The implementation of this BiCG-FFT solution algorithm is important in minimizing the CPU and storage requirements. This final report will be submitted for publication in a refereed journal.

Socio-demographic and work-related risk factors for medium- and long-term sickness absence among Italian workers.

PubMed

d'Errico, Angelo; Costa, Giuseppe

2012-10-01

Few studies investigated determinants of sickness absence in representative samples of the general population, none of which in Italy. Aim of this study was to assess influence and relative importance of socio-demographic and work-related characteristics on medium- and long-term sickness absence in a random sample of Italian workers. Approximately 60,000 workers participating in a national survey in 2007 were interviewed regarding sickness absence during the whole previous week, and on socio-demographics, employment characteristics and exposure to a set of physical and psychosocial hazards in the workplace. The association between sickness absence and potential determinants was estimated by multivariable logistic regression models stratified by gender. From the final multivariate models, in both genders sickness absence was statistically significantly associated with tenure employment, working in larger firms, exposure to risk of injury and to bullying or discrimination and, among employees, with shift work. In males, sickness absence was also associated with lower education, employment in the public administration and with exposure to noise or vibration, whereas among women also with manual work and ergonomic factors. In both genders, the attributable fraction for employment-related characteristics was higher than that for socio-demographic ones. The association with tenure or salaried jobs, and with employment in larger firms or in the public sector suggests that, besides illness, job security is the most important determinant of sickness absence, consistently with the results of previous studies. However, our results indicate that a reduction in exposure to workplace hazards may contribute to reduce absenteeism.

Can psychosocial work conditions protect against age-related cognitive decline? Results from a systematic review

PubMed Central

Nexø, Mette Andersen; Meng, Annette; Borg, Vilhelm

2016-01-01

According to the use it or lose it hypothesis, intellectually stimulating activities postpone age-related cognitive decline. A previous systematic review concluded that a high level of mental work demands and job control protected against cognitive decline. However, it did not distinguish between outcomes that were measured as cognitive function at one point in time or as cognitive decline. Our study aimed to systematically review which psychosocial working conditions were prospectively associated with high levels of cognitive function and/or changes in cognitive function over time. Articles were identified by a systematic literature search (MEDLINE, Web of Science (WOS), PsycNET, Occupational Safety and Health (OSH)). We included only studies with longitudinal designs examining the impact of psychosocial work conditions on outcomes defined as cognitive function or changes in cognitive function. Two independent reviewers compared title-abstract screenings, full-text screenings and quality assessment ratings. Eleven studies were included in the final synthesis and showed that high levels of mental work demands, occupational complexity or job control at one point in time were prospectively associated with higher levels of cognitive function in midlife or late life. However, the evidence to clarify whether these psychosocial factors also affected cognitive decline was insufficient, conflicting or weak. It remains speculative whether job control, job demands or occupational complexity can protect against cognitive decline. Future studies using methodological advancements can reveal whether workers gain more cognitive reserve in midlife and late life than the available evidence currently suggests. The public health implications of a previous review should thereby be redefined accordingly. PMID:27178844

[The changing spectrum of fever of unknown origin: trends and comparison with previous series at the Salvador Zubirán National Institute of Nutrition].

PubMed

Molina-Gamboa, J; Rivera-Morales, I; Camacho-Mezquita, E; Ponce-de-León, S

1994-01-01

We reviewed 400 medical records of patients admitted because of fever at the National Institute of Nutrition Salvador Zubirán between January 1, 1988 to December 31, 1992. Patient characteristics, diagnostic methods, final diagnosis and patient progress were analyzed, comparing these data with the previous series of the institute. We found 77 cases of fever of unknown origin (FUO), 47 males and 30 females, between 14 to 87 years of age. The final diagnosis encountered were: infections (40%), neoplasias (23%), collagen diseases (13%), and other diagnosis (8%). Sixteen percent of the cases remained without a final diagnosis. The most frequent infections were HIV infection (19%), tuberculosis (19%) and endocarditis (13%). The most common neoplasia was lymphoma (55.6%), with 90% of Hodgkin's disease. SLE was the most common autoimmune disease found. The methods to establish a final diagnosis were: biopsies (52%), serology (17%), cultures (12%), image (11%), and clinical (8%). Final diagnosis by serology tests increased from 2 to 17% in comparison with previous reports. Eight laparotomies were done, which is a less frequent practice than previously (10 vs 35%). We saw only one case of amebic hepatic abscess and had no cases of malaria and salmonellosis as final diagnosis of FUO; HIV infection was found to be a new major cause of FUO.

Gap-junction coupling and ATP-sensitive potassium channels in human β -cell clusters: Effects on emergent dynamics

NASA Astrophysics Data System (ADS)

Loppini, A.; Pedersen, M. G.; Braun, M.; Filippi, S.

2017-09-01

The importance of gap-junction coupling between β cells in pancreatic islets is well established in mouse. Such ultrastructural connections synchronize cellular activity, confine biological heterogeneity, and enhance insulin pulsatility. Dysfunction of coupling has been associated with diabetes and altered β -cell function. However, the role of gap junctions between human β cells is still largely unexplored. By using patch-clamp recordings of β cells from human donors, we previously estimated electrical properties of these channels by mathematical modeling of pairs of human β cells. In this work we revise our estimate by modeling triplet configurations and larger heterogeneous clusters. We find that a coupling conductance in the range 0.005 -0.020 nS/pF can reproduce experiments in almost all the simulated arrangements. We finally explore the consequence of gap-junction coupling of this magnitude between β cells with mutant variants of the ATP-sensitive potassium channels involved in some metabolic disorders and diabetic conditions, translating studies performed on rodents to the human case. Our results are finally discussed from the perspective of therapeutic strategies. In summary, modeling of more realistic clusters with more than two β cells slightly lowers our previous estimate of gap-junction conductance and gives rise to patterns that more closely resemble experimental traces.

Parameterization of Highly Charged Metal Ions Using the 12-6-4 LJ-Type Nonbonded Model in Explicit Water

PubMed Central

2015-01-01

Highly charged metal ions act as catalytic centers and structural elements in a broad range of chemical complexes. The nonbonded model for metal ions is extensively used in molecular simulations due to its simple form, computational speed, and transferability. We have proposed and parametrized a 12-6-4 LJ (Lennard-Jones)-type nonbonded model for divalent metal ions in previous work, which showed a marked improvement over the 12-6 LJ nonbonded model. In the present study, by treating the experimental hydration free energies and ion–oxygen distances of the first solvation shell as targets for our parametrization, we evaluated 12-6 LJ parameters for 18 M(III) and 6 M(IV) metal ions for three widely used water models (TIP3P, SPC/E, and TIP4PEW). As expected, the interaction energy underestimation of the 12-6 LJ nonbonded model increases dramatically for the highly charged metal ions. We then parametrized the 12-6-4 LJ-type nonbonded model for these metal ions with the three water models. The final parameters reproduced the target values with good accuracy, which is consistent with our previous experience using this potential. Finally, tests were performed on a protein system, and the obtained results validate the transferability of these nonbonded model parameters. PMID:25145273

Weight and See: Loading Working Memory Improves Incidental Identification of Irrelevant Faces

PubMed Central

Carmel, David; Fairnie, Jake; Lavie, Nilli

2012-01-01

Are task-irrelevant stimuli processed to a level enabling individual identification? This question is central both for perceptual processing models and for applied settings (e.g., eye-witness testimony). Lavie’s load theory proposes that working memory actively maintains attentional prioritization of relevant over irrelevant information. Loading working memory thus impairs attentional prioritization, leading to increased processing of task-irrelevant stimuli. Previous research has shown that increased working memory load leads to greater interference effects from response-competing distractors. Here we test the novel prediction that increased processing of irrelevant stimuli under high working memory load should lead to a greater likelihood of incidental identification of entirely irrelevant stimuli. To test this, we asked participants to perform a word-categorization task while ignoring task-irrelevant images. The categorization task was performed during the retention interval of a working memory task with either low or high load (defined by memory set size). Following the final experimental trial, a surprise question assessed incidental identification of the irrelevant image. Loading working memory was found to improve identification of task-irrelevant faces, but not of building stimuli (shown in a separate experiment to be less distracting). These findings suggest that working memory plays a critical role in determining whether distracting stimuli will be subsequently identified. PMID:22912623

From bosonic topological transition to symmetric fermion mass generation

NASA Astrophysics Data System (ADS)

You, Yi-Zhuang; He, Yin-Chen; Vishwanath, Ashvin; Xu, Cenke

2018-03-01

A bosonic topological transition (BTT) is a quantum critical point between the bosonic symmetry-protected topological phase and the trivial phase. In this work, we investigate such a transition in a (2+1)-dimensional lattice model with the maximal microscopic symmetry: an internal SO (4 ) symmetry. We derive a description for this transition in terms of compact quantum electrodynamics (QED) with four fermion flavors (Nf=4 ). Within a systematic renormalization group analysis, we identify the critical point with the desired O (4 ) emergent symmetry and all expected deformations. By lowering the microscopic symmetry, we recover the previous Nf=2 noncompact QED description of the BTT. Finally, by merging two BTTs we recover a previously discussed theory of symmetric mass generation, as an SU (2 ) quantum chromodynamics-Higgs theory with Nf=4 flavors of SU (2 ) fundamental fermions and one SU (2 ) fundamental Higgs boson. This provides a consistency check on both theories.

Glycerosomes: Use of hydrogenated soy phosphatidylcholine mixture and its effect on vesicle features and diclofenac skin penetration.

PubMed

Manca, Maria Letizia; Cencetti, Claudia; Matricardi, Pietro; Castangia, Ines; Zaru, Marco; Sales, Octavio Diez; Nacher, Amparo; Valenti, Donatella; Maccioni, Anna Maria; Fadda, Anna Maria; Manconi, Maria

2016-09-10

In this work, diclofenac was encapsulated, as sodium salt, in glycerosomes containing 10, 20 or 30% of glycerol in the water phase with the aim to ameliorate its topical efficacy. Taking into account previous findings, glycerosome formulation was modified, in terms of economic suitability, using a cheap and commercially available mixture of hydrogenated soy phosphatidylcholine (P90H). P90H glycerosomes were spherical and multilamellar; photon correlation spectroscopy showed that obtained vesicles were ∼131nm, slightly larger and more polydispersed than those made with dipalmitoylphosphatidylcholine (DPPC) but, surprisingly, they were able to ameliorate the local delivery of diclofenac, which was improved with respect to previous findings, in particular using glycerosomes containing high amount of glycerol (20 and 30%). Finally, this drug delivery system showed a high in vitro biocompatibility toward human keratinocytes. Copyright © 2016 Elsevier B.V. All rights reserved.

Update on the epidemiology of the rheumatic diseases.

PubMed

Gabriel, S E

1996-03-01

Epidemiologic studies continue to enhance our understanding of the rheumatic diseases. Such studies now indicate that 26 million American women are at risk for osteoporotic fractures. Contrary to previous recommendations, the identification and treatment of patients at risk for osteoporosis may be valuable even among very elderly people. Other epidemiologic studies suggest that the incidence of rheumatoid arthritis is decreasing and that it is a more benign disease than previously recognized. Osteoarthritis remains a leading cause of physical and work disability in North America. The roles of occupational physical activity, obesity, and highly competitive (though not low-impact) exercise as risk factors for osteoarthritis continue to be explored. Pharmacoepidemiologic research has recently demonstrated that a policy of prior authorization for prescription of nonsteroidal anti-inflammatory drugs may be highly cost effective. Finally, controlled epidemiologic studies have not confirmed an association between silicone breast implants and connective tissue diseases, a conclusion recently endorsed by the American College of Rheumatology.

Developmental Ethanol Exposure Leads to Dysregulation of Lipid Metabolism and Oxidative Stress in Drosophila

PubMed Central

Logan-Garbisch, Theresa; Bortolazzo, Anthony; Luu, Peter; Ford, Audrey; Do, David; Khodabakhshi, Payam; French, Rachael L.

2014-01-01

Ethanol exposure during development causes an array of developmental abnormalities, both physiological and behavioral. In mammals, these abnormalities are collectively known as fetal alcohol effects (FAE) or fetal alcohol spectrum disorder (FASD). We have established a Drosophila melanogaster model of FASD and have previously shown that developmental ethanol exposure in flies leads to reduced expression of insulin-like peptides (dILPs) and their receptor. In this work, we link that observation to dysregulation of fatty acid metabolism and lipid accumulation. Further, we show that developmental ethanol exposure in Drosophila causes oxidative stress, that this stress is a primary cause of the developmental lethality and delay associated with ethanol exposure, and, finally, that one of the mechanisms by which ethanol increases oxidative stress is through abnormal fatty acid metabolism. These data suggest a previously uncharacterized mechanism by which ethanol causes the symptoms associated with FASD. PMID:25387828

New approaches for measuring changes in the cortical surface using an automatic reconstruction algorithm

NASA Astrophysics Data System (ADS)

Pham, Dzung L.; Han, Xiao; Rettmann, Maryam E.; Xu, Chenyang; Tosun, Duygu; Resnick, Susan; Prince, Jerry L.

2002-05-01

In previous work, the authors presented a multi-stage procedure for the semi-automatic reconstruction of the cerebral cortex from magnetic resonance images. This method suffered from several disadvantages. First, the tissue classification algorithm used can be sensitive to noise within the image. Second, manual interaction was required for masking out undesired regions of the brain image, such as the ventricles and putamen. Third, iterated median filters were used to perform a topology correction on the initial cortical surface, resulting in an overly smoothed initial surface. Finally, the deformable surface used to converge to the cortex had difficulty capturing narrow gyri. In this work, all four disadvantages of the procedure have been addressed. A more robust tissue classification algorithm is employed and the manual masking step is replaced by an automatic method involving level set deformable models. Instead of iterated median filters, an algorithm developed specifically for topology correction is used. The last disadvantage is addressed using an algorithm that artificially separates adjacent sulcal banks. The new procedure is more automated but also more accurate than the previous one. Its utility is demonstrated by performing a preliminary study on data from the Baltimore Longitudinal Study of Aging.

Microstructure and properties of thermally sprayed Al-Sn-based alloys for plain bearing applications

NASA Astrophysics Data System (ADS)

Marrocco, T.; Driver, L. C.; Harris, S. J.; McCartney, D. G.

2006-12-01

Al-Sn plain bearings for automotive applications traditionally comprise a multilayer structure. Conventionally, bearing manufacturing involves casting the Al-Sn alloy and roll-bonding to a steel backing strip. Recently, high-velocity oxyfuel (HVOF) thermal spraying has been used as a novel alternative manufacturing route. The present project extends previous work on ternary Al-Sn-Cu alloys to quaternary systems, which contain specific additions for potentially enhanced properties. Two alloys were studied in detail, namely, Al-20wt.%Sn-1wt.%Cu-2wt.%Ni and Al-20wt.%Sn-1wt.%Cu-7wt.%Si. This article will describe the microstructural evolution of these alloys following HVOF spraying onto steel substrates and subsequent heat treatment. The microstructures of powders and coatings were investigated by scanning electron microscopy, and the phases were identified by x-ray diffraction. Coating microhardnesses were determined under both as-sprayed and heat-treated conditions, and by the differences related to the microstructures that developed. Finally, the wear behavior of the sprayed and heat-treated coatings in hot engine oil was measured using an industry standard test and was compared with that of previous work on a ternary alloy.

Precision saturated absorption spectroscopy of H3+

NASA Astrophysics Data System (ADS)

Guan, Yu-Chan; Chang, Yung-Hsiang; Liao, Yi-Chieh; Peng, Jin-Long; Wang, Li-Bang; Shy, Jow-Tsong

2018-03-01

In our previous work on the Lamb-dips of the ν2 fundamental band transitions of H3+, the saturated absorption spectrum was obtained by third-derivative spectroscopy using frequency modulation with an optical parametric oscillator (OPO). However, frequency modulation also caused errors in the absolute frequency determination. To solve this problem, we built a tunable offset locking system to lock the pump frequency of the OPO to an iodine-stabilized Nd:YAG laser. With this improvement, we were able to scan the OPO idler frequency precisely and obtain the saturated absorption profile using intensity modulation. Furthermore, ion concentration modulation was employed to subtract the background noise and increase the signal-to-noise ratio. To determine the absolute frequency of the idler wave, the OPO signal frequency was locked to an optical frequency comb. The absolute frequency accuracy of our spectrometer was better than 7 kHz, demonstrated by measuring the wavelength standard transition of methane at 3.39 μm. Finally, we measured 16 transitions of H3+ and our results agree very well with other precision measurements. This work successfully resolved the discrepancies between our previous measurements and other precision measurements.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nersisyan, Henrik; Cid, Adrian Fernandez; Amendola, Luca, E-mail: h.nersisyan@thphys.uni-heidelberg.de, E-mail: fernandez@thphys.uni-heidelberg.de, E-mail: l.amendola@thphys.uni-heidelberg.de

In this work, we extend previous analyses of the structure formation in the f (□{sup −1} R ) model of nonlocal gravity proposed by Deser and Woodard (DW), which reproduces the background expansion of ΛCDM with no need of a cosmological constant nor of any dimensional constant beside Newton's one. A previous analysis based on redshift-space distortions (RSD) data concluded that the model was ruled out. In this work we revisit the issue and find that, when recast in a localized model, the DW model is not ruled out and actually gives a better fit to RSD data than ΛCDM.more » In fact, the DW model presents a suppressed growth of matter perturbations with respect to ΛCDM and a slightly lower value of σ{sub 8}, as favored by observations. We also produce analytical approximations of the two modified gravity functions, i.e. the anisotropic stress η and the relative change of Newton's constant Y , and of f σ{sub 8}( z ) as a function of redshift. Finally, we also show how much the fit depends on initial conditions when these are generalized with respect to a standard matter-dominated era.« less

A Biologically Inspired Computational Model of Basal Ganglia in Action Selection.

PubMed

Baston, Chiara; Ursino, Mauro

2015-01-01

The basal ganglia (BG) are a subcortical structure implicated in action selection. The aim of this work is to present a new cognitive neuroscience model of the BG, which aspires to represent a parsimonious balance between simplicity and completeness. The model includes the 3 main pathways operating in the BG circuitry, that is, the direct (Go), indirect (NoGo), and hyperdirect pathways. The main original aspects, compared with previous models, are the use of a two-term Hebb rule to train synapses in the striatum, based exclusively on neuronal activity changes caused by dopamine peaks or dips, and the role of the cholinergic interneurons (affected by dopamine themselves) during learning. Some examples are displayed, concerning a few paradigmatic cases: action selection in basal conditions, action selection in the presence of a strong conflict (where the role of the hyperdirect pathway emerges), synapse changes induced by phasic dopamine, and learning new actions based on a previous history of rewards and punishments. Finally, some simulations show model working in conditions of altered dopamine levels, to illustrate pathological cases (dopamine depletion in parkinsonian subjects or dopamine hypermedication). Due to its parsimonious approach, the model may represent a straightforward tool to analyze BG functionality in behavioral experiments.

Event models and the fan effect.

PubMed

Radvansky, G A; O'Rear, Andrea E; Fisher, Jerry S

2017-08-01

The current study explored the persistence of event model organizations and how this influences the experience of interference during retrieval. People in this study memorized lists of sentences about objects in locations, such as "The potted palm is in the hotel." Previous work has shown that such information can either be stored in separate event models, thereby producing retrieval interference, or integrated into common event models, thereby eliminating retrieval interference. Unlike prior studies, the current work explored the impact of forgetting up to 2 weeks later on this pattern of performance. We explored three possible outcomes across the various retention intervals. First, consistent with research showing that longer delays reduce proactive and retroactive interference, any retrieval interference effects of competing event models could be reduced over time. Second, the binding of information into events models may weaken over time, causing interference effects to emerge when they had previously been absent. Third, and finally, the organization of information into event models could remain stable over long periods of time. The results reported here are most consistent with the last outcome. While there were some minor variations across the various retention intervals, the basic pattern of event model organization remained preserved over the two-week retention period.

Interventions for confusion and dementia. 5: Changing cultures.

PubMed

Woodrow, P

Previous articles in this series (Vol 7(15): 891-94; Vol 7(17): 1018-20; Vol 7(19): 1145-49; Vol 7(20): 1247-50) have explored the promotion of quality of life for people with dementia and how this can be achieved through existing interventions. This final article moves from discussing specific interventions to cover wider issues around healthcare beliefs and values. A brief historical overview of dementia care is given, outlining the inherited structures and values. Much valuable work has been carried out by the Bradford Dementia Group, who has described changes in dementia care as moving from an 'old' to a 'new' culture. This 'new culture', offering a comprehensive person-centred approach to holistic care, is explored with reference to the work of Kitwood, who has done much to promote quality of life for people suffering from dementia.

Visualization of N-body Simulations in Virtual Worlds

NASA Astrophysics Data System (ADS)

Knop, Robert A.; Ames, J.; Djorgovski, G.; Farr, W.; Hut, P.; Johnson, A.; McMillan, S.; Nakasone, A.; Vesperini, E.

2010-01-01

We report on work to use virtual worlds for visualizing the results of N-body calculations, on three levels. First, we have written a demonstration 3-body solver entirely in the scripting language of the popularly used virtual world Second Life. Second, we have written a physics module for the open source virtual world OpenSim that performs N-body calculations as the physics engine for the server, allowing natural 3-d visualization of the solution as the solution is being performed. Finally, we give an initial report on the potential use of virtual worlds to visualize calculations which have previously been performed, or which are being performed in other processes and reported to the virtual world server. This work has been performed as part of the Meta-Institute of Computational Astrophysics (MICA). http://www.mica-vw.org

Scalable data management, analysis and visualization (SDAV) Institute. Final Scientific/Technical Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Geveci, Berk

The purpose of the SDAV institute is to provide tools and expertise in scientific data management, analysis, and visualization to DOE’s application scientists. Our goal is to actively work with application teams to assist them in achieving breakthrough science, and to provide technical solutions in the data management, analysis, and visualization regimes that are broadly used by the computational science community. Over the last 5 years members of our institute worked directly with application scientists and DOE leadership-class facilities to assist them by applying the best tools and technologies at our disposal. We also enhanced our tools based on inputmore » from scientists on their needs. Many of the applications we have been working with are based on connections with scientists established in previous years. However, we contacted additional scientists though our outreach activities, as well as engaging application teams running on leading DOE computing systems. Our approach is to employ an evolutionary development and deployment process: first considering the application of existing tools, followed by the customization necessary for each particular application, and then the deployment in real frameworks and infrastructures. The institute is organized into three areas, each with area leaders, who keep track of progress, engagement of application scientists, and results. The areas are: (1) Data Management, (2) Data Analysis, and (3) Visualization. Kitware has been involved in the Visualization area. This report covers Kitware’s contributions over the last 5 years (February 2012 – February 2017). For details on the work performed by the SDAV institute as a whole, please see the SDAV final report.« less

The hopelessness theory of depression: attributional aspects.

PubMed

Alloy, L B; Abramson, L Y; Metalsky, G I; Hartlage, S

1988-02-01

In this article, we clarify, expand and revise the basic postulates of the hopelessness theory of depression (Abramson, Alloy & Metalsky, 1988a; Abramson, Metalsky & Alloy, 1987, 1988b; previously referred to as the reformulated helplessness theory of depression: Abramson, Seligman & Teasdale, 1978) and place the theory more explicitly in the context of work in descriptive psychiatry about the heterogeneity among the depressive disorders. We suggest that the hopelessness theory hypothesizes the existence in nature of an, as yet, unidentified subtype of depression--'hopelessness depression'--defined, in part, by its cause. We then give a critique of work conducted to test the hopelessness theory and explicate the limitations in research strategy associated with this line of work. Our critique includes a logical analysis that deduces the conceptual and methodological inadequacies of the research strategies used to test the theory. Finally, we suggest more adequate research strategies for testing the hopelessness theory and discuss conceptual and assessment issues that will arise in conducting such tests with special emphasis on attributional styles.

The stability of working memory: do previous tasks influence complex span?

PubMed

Healey, M Karl; Hasher, Lynn; Danilova, Elena

2011-11-01

Schmeichel (2007) reported that performing an initial task before completing a working memory span task can lower span scores and suggested that the effect was due to depleted cognitive resources. We showed that the detrimental effect of prior tasks depends on a match between the stimuli used in the span task and the preceding task. A task requiring participants to ignore words reduced performance on a subsequent word-based verbal span task but not on an arrow-based spatial span task. Ignoring arrows had the opposite pattern of effects: reducing performance on the spatial span task but not on the word-based span task. Finally, we showed that antisaccade, a nonverbal task that taxes domain-general processes implicated in working memory, did not influence subsequent performance of either a verbal or a spatial span task. Together these results suggest that while span is sensitive to prior tasks, that sensitivity does not stem from depleted resources. (PsycINFO Database Record (c) 2011 APA, all rights reserved).

Diversity-based reasoning in children.

PubMed

Heit, E; Hahn, U

2001-12-01

One of the hallmarks of inductive reasoning by adults is the diversity effect, namely that people draw stronger inferences from a diverse set of evidence than from a more homogenous set of evidence. However, past developmental work has not found consistent diversity effects with children age 9 and younger. We report robust sensitivity to diversity in children as young as 5, using everyday stimuli such as pictures of objects with people. Experiment 1 showed the basic diversity effect in 5- to 9-year-olds. Experiment 2 showed that, like adults, children restrict their use of diversity information when making inferences about remote categories. Experiment 3 used other stimulus sets to overcome an alternate explanation in terms of sample size rather than diversity effects. Finally, Experiment 4 showed that children more readily draw on diversity when reasoning about objects and their relations with people than when reasoning about objects' internal, hidden properties, thus partially explaining the negative findings of previous work. Relations to cross-cultural work and models of induction are discussed. Copyright 2001 Academic Press.

If It Works for Pills, Can It Work for Skills? Direct-to-Consumer Social Marketing of Evidence-Based Psychological Treatments.

PubMed

Friedberg, Robert D; Bayar, Hasan

2017-06-01

The emergence of evidence-based psychological treatments (EVPTs) is a scientific success story, but unfortunately the application of these empirically supported procedures has been slow to gain ground in treatment-as-usual settings. This Open Forum commentary argues that direct-to-consumer (DTC) marketing, which has worked well in communicating the advantages of various medicines, should perhaps be considered for use in social marketing of EVPTs. DTC marketing of pharmaceuticals is a long-standing advertising strategy in the United States. In fact, DTC marketing of psychotropic medicines is quite a success story. The authors recommend various strategies for using marketing science to devise DTC advertising of EVPTs, discuss previous research on DTC campaigns, and describe initiatives launched in the United Kingdom and Europe to promote EVPTs. Suggestions for evaluating and regulating DTC marketing of EVPTs are included. Finally, the potential for DTC marketing of EVPTs to increase mental health literacy and reduce health disparities is explored.

Experimental Study and Optimization of Thermoelectricity-Driven Autonomous Sensors for the Chimney of a Biomass Power Plant

NASA Astrophysics Data System (ADS)

Rodríguez, A.; Astrain, D.; Martínez, A.; Aranguren, P.

2014-06-01

In the work discussed in this paper a thermoelectric generator was developed to harness waste heat from the exhaust gas of a boiler in a biomass power plant and thus generate electric power to operate a flowmeter installed in the chimney, to make it autonomous. The main objective was to conduct an experimental study to optimize a previous design obtained after computational work based on a simulation model for thermoelectric generators. First, several places inside and outside the chimney were considered as sites for the thermoelectricity-driven autonomous sensor. Second, the thermoelectric generator was built and tested to assess the effect of the cold-side heat exchanger on the electric power, power consumption by the flowmeter, and transmission frequency. These tests provided the best configuration for the heat exchanger, which met the transmission requirements for different working conditions. The final design is able to transmit every second and requires neither batteries nor electric wires. It is a promising application in the field of thermoelectric generation.

Follower Jealousy at Work: A Test of Vecchio's Model of Antecedents and Consequences of Jealousy.

PubMed

Thompson, Geir; Buch, Robert; Glasø, Lars

2018-01-02

The present study tests the validity of Robert P. Vecchio's seminal work on antecedents and consequences of jealousy. Specifically, we examine whether antecedents such as in-group status, supervisory considerateness, and supervisory differentiation of subordinates are associated with jealousy. In addition, we examine whether jealousy is associated with the outcome variable of social loafing. Leaders (n = 73) and their followers (n = 303) working in business organizations in Norway contributed data. Multilevel analyses showed that a high-quality working relationship with one's supervisor was inversely related to reports of jealousy. In addition, supervisors who displayed high levels of considerateness, for example, by providing followers with positive emotional support, were better able to reduce subordinate jealousy. This is a novel observation since previous research failed to demonstrate such a relationship. Finally, jealousy was positively associated with social loafing, suggesting that jealous followers engaged in an active counterproductive resistance response. The present study contributes to the extant literature by identifying unexamined antecedents of jealousy and a dysfunctional behavioral response to jealousy in the form of social loafing in the workplace.

The contributions of human factors and ergonomics to a sustainable minerals industry.

PubMed

Horberry, Tim; Burgess-Limerick, Robin; Fuller, Ruth

2013-01-01

This article describes examples of the application of human factors research and development work to a sustainable minerals industry. It begins by outlining human-related aspects of the minerals industry and the key human factors work previously undertaken in this domain. The focus then switches to sustainability in the minerals industry. Sustainability principles are introduced and illustrations provided of how human factors research and development work fits within such a framework. Three case studies of human factors in the minerals industry research are presented and the sustainability implications in each case study are highlighted. Finally, future trends related to human factors work in a sustainable minerals industry are addressed, in particular the opportunities and possible adverse consequences that increasing deployment of mining automation might bring. Minerals industries are a major global activity with significant sustainability implications. Aspects of sustainability in mining are examined using three case studies. These illustrate the contribution of human factors/ergonomics in reducing risks; developing emergency response management systems; and the value of participatory ergonomics in improving the design of mining equipment.

Near millimeter wave imaging/multi-beam integrated antennas

NASA Technical Reports Server (NTRS)

Yngvesson, K. S.; Schaubert, D. H.

1985-01-01

This report describes the most recent work on the theory of single element Linearly Tapered Slot Antennas (LTSAs) and Constant Width Slot Antennas (CWSAs). The radiation mechanism for these is presently well understood and allows quantitative calculation of beamwidths and sidelobe levels, provided that the antennas have a sufficiently wide conducting region on either side of the tapered slot. Appendices 4 to 7 represent earlier work on the grant. This work further elucidates the properties of arrays of CWSA elements, and the effects of coupling on the beam-shape. It should be noted that typical beam-efficiencies of 65% have been estimated, and that element spacings of about one Rayleigh unit are possible. Further, two-point resolution at the Rayleigh spacing has been demonstrated for a CWSA array in a 30.4 cm paraboloid at 31 GHz. These results underscore that interest in further studies of the radiation mechanism of tapered slot arrays. Appendix 7 constitutes a final, detailed report on the work leading to a 94 GHz seven element LTSA array imaging system, which has been reported previously in less detail. Experimental results are presented.

Final Project Report for DOE Grant NO.: DE-SC0010534 Period: Sept 2013-March 31, 2016

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gunaydin, Murat

2016-08-01

Higher spin theories has been an active area of research in recent years. One of the main research activities of the PI Murat Gunaydin over the period of this grant has been the application of quasiconformal methods to construct and study higher spin (HS) algebras and superalgebras in various dimensions. Over the past decade work on amplitudes in gauge theories, supergravity and string theories has been a very active area of research. Enormous progress has been made in the understanding of the structure of amplitudes in these theories. The novel methods and results obtained have made it possible to domore » calculations in gauge theories and supergravity theories that go well beyond the calculations one can do using the old-fashioned Feynman diagram techniques. Work on amplitudes in matter-coupled supergravity theories has been the second main focus of the PI during the funding period. The previous work of the PI on supergravity theories has played a fundamentally important role in the current work on amplitudes.« less

Daily hassles and uplifts: a diary study on understanding relationship quality.

PubMed

Totenhagen, Casey J; Serido, Joyce; Curran, Melissa A; Butler, Emily A

2012-10-01

In this investigation, we use the Conservation of Resources (CoR) theory as a guide to examine how both uplifts and hassles are associated with positive (e.g., satisfaction, commitment) and negative (ambivalence, conflict) relational quality on a daily basis. In previous studies of hassles and uplifts, the focus has been primarily on negative outcomes at the individual level (e.g., affect). Here, we build on this previous research in examining both positive and negative events (i.e., uplifts and hassles) in associations with positive and negative relational qualities. Further, we focus on examining social and nonsocial events that are external to the relationship (i.e., do not involve the romantic partner) and how they are linked with relational qualities. Finally, we examine which patterns are confined to the same day and which carry over to subsequent days (i.e., lagged effects). Contrary to previous literature, we find that both social and nonsocial hassles are largely unrelated to relationship quality after accounting for the effects of social and nonsocial uplifts. In contrast, nonsocial uplifts bolster positive feelings about the relationship on that day. Results also show that hassles and uplifts may work together to explain relational commitment. Finally, we find that nonsocial uplifts experienced on one day are associated with trend-level declines in next day positive feelings about the relationship. Our findings suggest that preserving relationship quality through daily experiences is best achieved by equipping couples to recognize the benefits of uplifts to the relationship, especially uplifts that are nonsocial, in tandem with managing hassles. (PsycINFO Database Record (c) 2012 APA, all rights reserved).

Do interruptions affect quality of work?

PubMed

Foroughi, Cyrus K; Werner, Nicole E; Nelson, Erik T; Boehm-Davis, Deborah A

2014-11-01

The aim of this study was to determine if interruptions affect the quality of work. Interruptions are commonplace at home and in the office. Previous research in this area has traditionally involved time and errors as the primary measures of disruption. Little is known about the effect interruptions have on quality of work. Fifty-four students outlined and wrote three essays using a within-subjects design. During Condition 1, interruptions occurred while participants were outlining. During Condition 2, interruptions occurred while they were writing. No interruptions occurred in Condition 3. Quality of work was significantly reduced in both interruption conditions when compared to the non-interruption condition. The number of words produced was significantly reduced when participants were interrupted while writing the essay but not when outlining the essay. This research represents a crucial first step in understanding the effect interruptions have on quality of work. Our research suggests that interruptions negatively impact quality of work during a complex, creative writing task. Since interruptions are such a prevalent part of daily life, more research needs to be conducted to determine what other tasks are negatively impacted. Moreover, the underlying mechanism(s) causing these decrements needs to be identified. Finally, strategies and systems need to be designed and put in place to help counteract the decline in quality of work caused by interruptions.

The development of a survey instrument for community health improvement.

PubMed Central

Bazos, D A; Weeks, W B; Fisher, E S; DeBlois, H A; Hamilton, E; Young, M J

2001-01-01

OBJECTIVE: To develop a survey instrument that could be used both to guide and evaluate community health improvement efforts. DATA SOURCES/STUDY SETTING: A randomized telephone survey was administered to a sample of about 250 residents in two communities in Lehigh Valley, Pennsylvania in the fall of 1997. METHODS: The survey instrument was developed by health professionals representing diverse health care organizations. This group worked collaboratively over a period of two years to (1) select a conceptual model of health as a foundation for the survey; (2) review relevant literature to identify indicators that adequately measured the health constructs within the chosen model; (3) develop new indicators where important constructs lacked specific measures; and (4) pilot test the final survey to assess the reliability and validity of the instrument. PRINCIPAL FINDINGS: The Evans and Stoddart Field Model of the Determinants of Health and Well-Being was chosen as the conceptual model within which to develop the survey. The Field Model depicts nine domains important to the origins and production of health and provides a comprehensive framework from which to launch community health improvement efforts. From more than 500 potential indicators we identified 118 survey questions that reflected the multiple determinants of health as conceptualized by this model. Sources from which indicators were selected include the Behavior Risk Factor Surveillance Survey, the National Health Interview Survey, the Consumer Assessment of Health Plans Survey, and the SF-12 Summary Scales. The work group developed 27 new survey questions for constructs for which we could not locate adequate indicators. Twenty-five questions in the final instrument can be compared to nationally published norms or benchmarks. The final instrument was pilot tested in 1997 in two communities. Administration time averaged 22 minutes with a response rate of 66 percent. Reliability of new survey questions was adequate. Face validity was supported by previous findings from qualitative and quantitative studies. CONCLUSIONS: We developed, pilot tested, and validated a survey instrument designed to provide more comprehensive and timely data to communities for community health assessments. This instrument allows communities to identify and measure critical domains of health that have previously not been captured in a single instrument. PMID:11508639

DOE Office of Scientific and Technical Information (OSTI.GOV)

Malone, Fionn D., E-mail: f.malone13@imperial.ac.uk; Lee, D. K. K.; Foulkes, W. M. C.

The recently developed density matrix quantum Monte Carlo (DMQMC) algorithm stochastically samples the N-body thermal density matrix and hence provides access to exact properties of many-particle quantum systems at arbitrary temperatures. We demonstrate that moving to the interaction picture provides substantial benefits when applying DMQMC to interacting fermions. In this first study, we focus on a system of much recent interest: the uniform electron gas in the warm dense regime. The basis set incompleteness error at finite temperature is investigated and extrapolated via a simple Monte Carlo sampling procedure. Finally, we provide benchmark calculations for a four-electron system, comparing ourmore » results to previous work where possible.« less

High resolution time-to-space conversion of sub-picosecond pulses at 1.55µm by non-degenerate SFG in PPLN crystal.

PubMed

Shayovitz, Dror; Herrmann, Harald; Sohler, Wolfgang; Ricken, Raimund; Silberhorn, Christine; Marom, Dan M

2012-11-19

We demonstrate high resolution and increased efficiency background-free time-to-space conversion using spectrally resolved non-degenerate and collinear SFG in a bulk PPLN crystal. A serial-to-parallel resolution factor of 95 and a time window of 42 ps were achieved. A 60-fold increase in conversion efficiency slope compared with our previous work using a BBO crystal [D. Shayovitz and D. M. Marom, Opt. Lett. 36, 1957 (2011)] was recorded. Finally the measured 40 GHz narrow linewidth of the output SFG signal implies the possibility to extract phase information by employing coherent detection techniques.

Mean-Variance Hedging on Uncertain Time Horizon in a Market with a Jump

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kharroubi, Idris, E-mail: kharroubi@ceremade.dauphine.fr; Lim, Thomas, E-mail: lim@ensiie.fr; Ngoupeyou, Armand, E-mail: armand.ngoupeyou@univ-paris-diderot.fr

2013-12-15

In this work, we study the problem of mean-variance hedging with a random horizon T∧τ, where T is a deterministic constant and τ is a jump time of the underlying asset price process. We first formulate this problem as a stochastic control problem and relate it to a system of BSDEs with a jump. We then provide a verification theorem which gives the optimal strategy for the mean-variance hedging using the solution of the previous system of BSDEs. Finally, we prove that this system of BSDEs admits a solution via a decomposition approach coming from filtration enlargement theory.

Application of radar for automotive collision avoidance. Volume 2: Development plan and progress reports

NASA Technical Reports Server (NTRS)

Lichtenberg, Christopher L. (Editor)

1987-01-01

The purpose of this project was research and development of an automobile collision avoidance radar system. Items within the scope of the one-year effort were to: (1) review previous authors' work in this field; (2) select a suitable radar approach; (3) develop a system design; (4) perform basic analyses and observations pertinent to radar design, performance, and effects; (5) fabricate and collect radar data from a data collection radar; (6) analyze and derive conclusions from the radar data; and (7) make recommendations about the likelihood of success of the investigated radar techniques. The final technical report presenting all conclusions is contained in Volume 1.

Theory, Image Simulation, and Data Analysis of Chemical Release Experiments

NASA Technical Reports Server (NTRS)

Wescott, Eugene M.

1994-01-01

The final phase of Grant NAG6-1 involved analysis of physics of chemical releases in the upper atmosphere and analysis of data obtained on previous NASA sponsored chemical release rocket experiments. Several lines of investigation of past chemical release experiments and computer simulations have been proceeding in parallel. This report summarizes the work performed and the resulting publications. The following topics are addressed: analysis of the 1987 Greenland rocket experiments; calculation of emission rates for barium, strontium, and calcium; the CRIT 1 and 2 experiments (Collisional Ionization Cross Section experiments); image calibration using background stars; rapid ray motions in ionospheric plasma clouds; and the NOONCUSP rocket experiments.

A premier analysis of supersymmetric closed string tachyon cosmology

NASA Astrophysics Data System (ADS)

Vázquez-Báez, V.; Ramírez, C.

2018-04-01

From a previously found worldline supersymmetric formulation for the effective action of the closed string tachyon in a FRW background, the Hamiltonian of the theory is constructed, by means of the Dirac procedure, and written in a quantum version. Using the supersymmetry algebra we are able to find solutions to the Wheeler-DeWitt equation via a more simple set of first order differential equations. Finally, for the k = 0 case, we compute the expectation value of the scale factor with a suitably potential also favored in the present literature. We give some interpretations of the results and state future work lines on this matter.

Tachyon and quintessence in brane worlds

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chimento, Luis P.; Forte, Monica; Richarte, Martin G.

2009-04-15

Using tachyon or quintessence fields along with a barotropic fluid on the brane we examine the different cosmological stages in a Friedmann-Robertson-Walker universe, from the first radiation scenario to the later era dominated by cosmic string networks. We introduce a new algorithm to generalize previous works on exact solutions and apply it to study tachyon and quintessence fields localized on the brane. We also explore the low and high energy regimes of the solutions. Besides, we show that the tachyon and quintessence fields are driven by an inverse power law potential. Finally, we find several simple exacts solutions for tachyonmore » and/or quintessence fields.« less

Final technical report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Loveland, Walter David

2016-08-27

This report describes the research carried out under this grant for the period from 1997 to 2014. This work has been previously described in annual progress reports and renewal applications. As a result of this project, ~100 papers were published in open refereed journals and 107 invited talks were given by the PI. The research subjects covered by this project included the synthesis and characterization of super-heavy nuclei, the critical study of the reaction mechanisms used in these synthesis reactions, the mechanism(s) of intermediate energy and relativistic nuclear collisions, the study of reactions induced by radioactive nuclear beams, and generalmore » properties of the heaviest elements.« less

Multiple core-hole formation by free-electron laser radiation in molecular nitrogen

NASA Astrophysics Data System (ADS)

Banks, H. I. B.; Little, D. A.; Emmanouilidou, A.

2018-05-01

We investigate the formation of multiple-core-hole states of molecular nitrogen interacting with a free-electron laser pulse. In previous work, we obtained bound and continuum molecular orbitals in the single-center expansion scheme and used these orbitals to calculate photo-ionization and auger decay rates. We extend our formulation to track the proportion of the population that accesses single-site versus two-site double-core-hole (TSDCH) states, before the formation of the final atomic ions. We investigate the pulse parameters that favor the formation of the single-site and TSDCH as well as triple-core-hole states for 525 and 1100 eV photons.

An agent-based computational model for tuberculosis spreading on age-structured populations

NASA Astrophysics Data System (ADS)

Graciani Rodrigues, C. C.; Espíndola, Aquino L.; Penna, T. J. P.

2015-06-01

In this work we present an agent-based computational model to study the spreading of the tuberculosis (TB) disease on age-structured populations. The model proposed is a merge of two previous models: an agent-based computational model for the spreading of tuberculosis and a bit-string model for biological aging. The combination of TB with the population aging, reproduces the coexistence of health states, as seen in real populations. In addition, the universal exponential behavior of mortalities curves is still preserved. Finally, the population distribution as function of age shows the prevalence of TB mostly in elders, for high efficacy treatments.

Hierarchical Traces for Reduced NSM Memory Requirements

NASA Astrophysics Data System (ADS)

Dahl, Torbjørn S.

This paper presents work on using hierarchical long term memory to reduce the memory requirements of nearest sequence memory (NSM) learning, a previously published, instance-based reinforcement learning algorithm. A hierarchical memory representation reduces the memory requirements by allowing traces to share common sub-sequences. We present moderated mechanisms for estimating discounted future rewards and for dealing with hidden state using hierarchical memory. We also present an experimental analysis of how the sub-sequence length affects the memory compression achieved and show that the reduced memory requirements do not effect the speed of learning. Finally, we analyse and discuss the persistence of the sub-sequences independent of specific trace instances.

Training, Quality Assurance Factors, and Tools Investigation: a Work Report and Suggestions on Software Quality Assurance

NASA Technical Reports Server (NTRS)

Lee, Pen-Nan

1991-01-01

Previously, several research tasks have been conducted, some observations were obtained, and several possible suggestions have been contemplated involving software quality assurance engineering at NASA Johnson. These research tasks are briefly described. Also, a brief discussion is given on the role of software quality assurance in software engineering along with some observations and suggestions. A brief discussion on a training program for software quality assurance engineers is provided. A list of assurance factors as well as quality factors are also included. Finally, a process model which can be used for searching and collecting software quality assurance tools is presented.

Video auto stitching in multicamera surveillance system

NASA Astrophysics Data System (ADS)

He, Bin; Zhao, Gang; Liu, Qifang; Li, Yangyang

2012-01-01

This paper concerns the problem of video stitching automatically in a multi-camera surveillance system. Previous approaches have used multiple calibrated cameras for video mosaic in large scale monitoring application. In this work, we formulate video stitching as a multi-image registration and blending problem, and not all cameras are needed to be calibrated except a few selected master cameras. SURF is used to find matched pairs of image key points from different cameras, and then camera pose is estimated and refined. Homography matrix is employed to calculate overlapping pixels and finally implement boundary resample algorithm to blend images. The result of simulation demonstrates the efficiency of our method.

Video auto stitching in multicamera surveillance system

NASA Astrophysics Data System (ADS)

He, Bin; Zhao, Gang; Liu, Qifang; Li, Yangyang

2011-12-01

This paper concerns the problem of video stitching automatically in a multi-camera surveillance system. Previous approaches have used multiple calibrated cameras for video mosaic in large scale monitoring application. In this work, we formulate video stitching as a multi-image registration and blending problem, and not all cameras are needed to be calibrated except a few selected master cameras. SURF is used to find matched pairs of image key points from different cameras, and then camera pose is estimated and refined. Homography matrix is employed to calculate overlapping pixels and finally implement boundary resample algorithm to blend images. The result of simulation demonstrates the efficiency of our method.

A New Class of Macrocyclic Chiral Selectors for Stereochemical Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1999-03-11

This report summarizes the work accomplished in the authors laboratories over the previous three years. During the funding period they have had 23 monographs published or in press, 1 book chapter, 1 patent issued and have delivered 28 invited seminars or plenary lectures on DOE sponsored research. This report covers the work that has been published (or accepted). The most notable aspect of this work involves the successful development and understanding of a new class of fused macrocyclic compounds as pseudophases and selectors in high performance separations (including high performance liquid chromatography, HPLC; capillary electrophoresis, CE; and thin layer chromatography,more » TLC). They have considerably extended their chiral biomarker work from amber to crude oil and coal. In the process of doing this we've developed several novel separation approaches. They finished their work on the new GSC-PLOT column which is now being used by researchers world-wide for the analysis of gases, light hydrocarbons and halocarbons. Finally, we completed basic studies on immobilizing a cyclodextrin/oligosiloxane hybrid on the wall of fused silica, as well as a basic study on the separation behavior of buckminster fullerene and higher fullerenes.« less

Can psychosocial work conditions protect against age-related cognitive decline? Results from a systematic review.

PubMed

Nexø, Mette Andersen; Meng, Annette; Borg, Vilhelm

2016-07-01

According to the use it or lose it hypothesis, intellectually stimulating activities postpone age-related cognitive decline. A previous systematic review concluded that a high level of mental work demands and job control protected against cognitive decline. However, it did not distinguish between outcomes that were measured as cognitive function at one point in time or as cognitive decline. Our study aimed to systematically review which psychosocial working conditions were prospectively associated with high levels of cognitive function and/or changes in cognitive function over time. Articles were identified by a systematic literature search (MEDLINE, Web of Science (WOS), PsycNET, Occupational Safety and Health (OSH)). We included only studies with longitudinal designs examining the impact of psychosocial work conditions on outcomes defined as cognitive function or changes in cognitive function. Two independent reviewers compared title-abstract screenings, full-text screenings and quality assessment ratings. Eleven studies were included in the final synthesis and showed that high levels of mental work demands, occupational complexity or job control at one point in time were prospectively associated with higher levels of cognitive function in midlife or late life. However, the evidence to clarify whether these psychosocial factors also affected cognitive decline was insufficient, conflicting or weak. It remains speculative whether job control, job demands or occupational complexity can protect against cognitive decline. Future studies using methodological advancements can reveal whether workers gain more cognitive reserve in midlife and late life than the available evidence currently suggests. The public health implications of a previous review should thereby be redefined accordingly. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Stopping decisions: information order effects on nonfocal evaluations.

PubMed

Yu, Michael; Gonzalez, Cleotilde

2013-08-01

We investigated how the order in which information is presented affects when a person decides to stop performing a task. A stopping decision is a decision to stop performing a task on the basis of a sequence of cues. Previous order-effects models do not account for how these contexts limit available working memory for making such decisions. Participants decided how long to perform a task known as the Work Hazard Game that began by rewarding points but later cost points if work continued after an unannounced "emergency." An additive sequence of cues indicated the probability of an emergency. Study I involved a three-group design with cue sequences that indicated the same risk at each decision point but whose final cue presented a high, medium, or low probability. Study 2 had a 2 x 2 design with high or low final cues and an easy or a challenging task. In Study I, participants stopped sooner when the most recent cue presented a high rather than low probability (p = .09), despite the same emergency risk. In Study 2, participants stopped sooner when the most recent cue presented a high rather than low probability for the challenging task but not for the easy task (p = .08). Stopping decisions appear sensitive to the most recent cue observed while experiencing task load. Participants responded to the same risks differently only on the basis of a change in presentation. Findings may be relevant for research and training for hazardous jobs, such as subsurface coal mining, fishing, and trucking.

On bipartite pure-state entanglement structure in terms of disentanglement

NASA Astrophysics Data System (ADS)

Herbut, Fedor

2006-12-01

Schrödinger's disentanglement [E. Schrödinger, Proc. Cambridge Philos. Soc. 31, 555 (1935)], i.e., remote state decomposition, as a physical way to study entanglement, is carried one step further with respect to previous work in investigating the qualitative side of entanglement in any bipartite state vector. Remote measurement (or, equivalently, remote orthogonal state decomposition) from previous work is generalized to remote linearly independent complete state decomposition both in the nonselective and the selective versions. The results are displayed in terms of commutative square diagrams, which show the power and beauty of the physical meaning of the (antiunitary) correlation operator inherent in the given bipartite state vector. This operator, together with the subsystem states (reduced density operators), constitutes the so-called correlated subsystem picture. It is the central part of the antilinear representation of a bipartite state vector, and it is a kind of core of its entanglement structure. The generalization of previously elaborated disentanglement expounded in this article is a synthesis of the antilinear representation of bipartite state vectors, which is reviewed, and the relevant results of [Cassinelli et al., J. Math. Anal. Appl. 210, 472 (1997)] in mathematical analysis, which are summed up. Linearly independent bases (finite or infinite) are shown to be almost as useful in some quantum mechanical studies as orthonormal ones. Finally, it is shown that linearly independent remote pure-state preparation carries the highest probability of occurrence. This singles out linearly independent remote influence from all possible ones.

Code subspaces for LLM geometries

NASA Astrophysics Data System (ADS)

Berenstein, David; Miller, Alexandra

2018-03-01

We consider effective field theory around classical background geometries with a gauge theory dual, specifically those in the class of LLM geometries. These are dual to half-BPS states of N= 4 SYM. We find that the language of code subspaces is natural for discussing the set of nearby states, which are built by acting with effective fields on these backgrounds. This work extends our previous work by going beyond the strict infinite N limit. We further discuss how one can extract the topology of the state beyond N→∞ and find that, as before, uncertainty and entanglement entropy calculations provide a useful tool to do so. Finally, we discuss obstructions to writing down a globally defined metric operator. We find that the answer depends on the choice of reference state that one starts with. Therefore, within this setup, there is ambiguity in trying to write an operator that describes the metric globally.

Trimethylsulfonium hydroxide as derivatization reagent for the chemical investigation of drying oils in works of art by gas chromatography.

PubMed

Dron, Julien; Linke, Robert; Rosenberg, Erwin; Schreiner, Manfred

2004-08-20

A procedure for the determination of fatty acids (FA) and glycerol in oils has been developed. The method includes a derivatization step of the FAs into their methyl esters or a transesterification of the triacylglycerols with trimethylsulfonium hydroxide (TMSH), respectively. The analysis is carried out by gas chromatography with parallel flame ionization and mass spectrometric detection. The parameters involved in the transesterification reaction were optimized. Only the stoichiometric ratio of TMSH:total FA amount showed a significant influence on the reaction yield. Relative standard deviations for 10 replicates were below 3% for all FAs studied and their linearity range was 0.5-50 mmol/L, when using heptadecanoic acid as an internal standard. The final procedure was rapid and required little sample handling. It was then tested on fresh oil samples and presented satisfying results, in agreement with previous works.

Testing HyDE on ADAPT

NASA Technical Reports Server (NTRS)

Sweet, Adam

2008-01-01

The IVHM Project in the Aviation Safety Program has funded research in electrical power system (EPS) health management. This problem domain contains both discrete and continuous behavior, and thus is directly relevant for the hybrid diagnostic tool HyDE. In FY2007 work was performed to expand the HyDE diagnosis model of the ADAPT system. The work completed resulted in a HyDE model with the capability to diagnose five times the number of ADAPT components previously tested. The expanded diagnosis model passed a corresponding set of new ADAPT fault injection scenario tests with no incorrect faults reported. The time required for the HyDE diagnostic system to isolate the fault varied widely between tests; this variance was reduced by tuning HyDE input parameters. These results and other diagnostic design trade-offs are discussed. Finally, possible future improvements for both the HyDE diagnostic model and HyDE itself are presented.

Irreversible thermodynamic analysis and application for molecular heat engines

NASA Astrophysics Data System (ADS)

Lucia, Umberto; Açıkkalp, Emin

2017-09-01

Is there a link between the macroscopic approach to irreversibility and microscopic behaviour of the systems? Consumption of free energy keeps the system away from a stable equilibrium. Entropy generation results from the redistribution of energy, momentum, mass and charge. This concept represents the essence of the thermodynamic approach to irreversibility. Irreversibility is the result of the interaction between systems and their environment. The aim of this paper is to determine lost works in a molecular engine and compare results with macro (classical) heat engines. Firstly, irreversible thermodynamics are reviewed for macro and molecular cycles. Secondly, irreversible thermodynamics approaches are applied for a quantum heat engine with -1/2 spin system. Finally, lost works are determined for considered system and results show that macro and molecular heat engines obey same limitations. Moreover, a quantum thermodynamic approach is suggested in order to explain the results previously obtained from an atomic viewpoint.

Information Filtering via Heterogeneous Diffusion in Online Bipartite Networks

PubMed Central

Zhang, Fu-Guo; Zeng, An

2015-01-01

The rapid expansion of Internet brings us overwhelming online information, which is impossible for an individual to go through all of it. Therefore, recommender systems were created to help people dig through this abundance of information. In networks composed by users and objects, recommender algorithms based on diffusion have been proven to be one of the best performing methods. Previous works considered the diffusion process from user to object, and from object to user to be equivalent. We show in this work that it is not the case and we improve the quality of the recommendation by taking into account the asymmetrical nature of this process. We apply this idea to modify the state-of-the-art recommendation methods. The simulation results show that the new methods can outperform these existing methods in both recommendation accuracy and diversity. Finally, this modification is checked to be able to improve the recommendation in a realistic case. PMID:26125631

THERMODYNAMICS OF FE-CU ALLOYS AS DESCRIBED BY A CLASSIC POTENTIALS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Caro, A; Caro, M; Lopasso, E M

2005-04-14

The Fe-Cu system is of relevance to the nuclear industry because of the deleterious consequences of Cu precipitates in the mechanical properties of Fe. Several sets of classical potentials are used in molecular dynamics simulations studies of this system, in particular that proposed by Ludwig et al. (Modelling Simul. Mater. Sci. Eng. 6, 19 (1998)). In this work we extract thermodynamic information from this interatomic potentials. We obtain equilibrium phase diagram and find a reasonable agreement with the experimental phases in the regions of relevance to radiation damage studies. We compare the results with the predicted phase diagram based onmore » other potential, as calculated in previous work. We discuss the disagreements found between the phase diagram calculated here and experimental results, focusing on the pure components and discuss the applicability of these potentials; finally we suggest an approach to improve existing potentials for this system.« less

Long-range Prethermal Time Crystals

NASA Astrophysics Data System (ADS)

Machado, Francisco; Meyer, Gregory D.; Else, Dominic; Olund, Christopher; Nayak, Chetan; Yao, Norman Y.

2017-04-01

Driven quantum systems have recently enabled the realization of a discrete time crystal - an intrinsically out-of-equilibrium phase of matter. One strategy to prevent the drive-induced, runaway heating of the time crystal is the presence of strong disorder leading to many-body localization (MBL). A more elegant, disorder-less approach is simply to work in the prethermal regime where time crystalline order can persist to exponentially long times. One key difference between prethermal and MBL time crystals is that the former is prohibited from existing in one dimensional systems with short-range interactions. In this work, we demonstrate that long-range interactions can stabilize a one dimensional prethermal time crystal. By numerically studying the pre-thermal regime, we find evidence for a phase transition out of the time crystal as a function of increasing energy density. Finally, generalizations of previous analytical bounds for the heating time-scale of driven quantum systems to long-range interactions will also be discussed.

Avian Models for Human Cognitive Neuroscience: A Proposal.

PubMed

Clayton, Nicola S; Emery, Nathan J

2015-06-17

Research on avian cognitive neuroscience over the past two decades has revealed the avian brain to be a better model for understanding human cognition than previously thought, despite differences in the neuroarchitecture of avian and mammalian brains. The brain, behavior, and cognition of songbirds have provided an excellent model of human cognition in one domain, namely learning human language and the production of speech. There are other important behavioral candidates of avian cognition, however, notably the capacity of corvids to remember the past and plan for the future, as well as their ability to think about another's perspective, and physical reasoning. We review this work and assess the evidence that the corvid brain can support such a cognitive architecture. We propose potential applications of these behavioral paradigms for cognitive neuroscience, including recent work on single-cell recordings and neuroimaging in corvids. Finally, we discuss their impact on understanding human developmental cognition. Copyright © 2015 Elsevier Inc. All rights reserved.

Does Leaders' Health (and Work-Related Experiences) Affect their Evaluation of Followers' Stress?

PubMed

Giorgi, Gabriele; Mancuso, Serena; Fiz Perez, Francisco Javier; Montani, Francesco; Courcy, Francois; Arcangeli, Giulio

2015-09-01

Stressed workers suffer from severe health problems which appear to have increased. Poor leadership is especially considered a source of stress. Indeed, supervisors might perceive their subordinates to be similar to them as far as stress is concerned and this might more widespread in organizations than previously thought. The present research investigates the relationships between leaders' health, in terms of work-related stress, mental health, and workplace bullying and their evaluation of subordinates' stress. Five regression models were formulated to test our hypothesis. This is a cross-sectional study among 261 Italian leaders, using supervisor self-assessment and leaders' assessments of their subordinates. Leaders' health was related to their evaluation of staff stress. Job demand, lack of job control, and lack of support by colleagues and supervisors evaluated in their subordinates were particularly associated with the leaders' own health. Implications for developing healthy leaders are finally discussed.

Lithospheric Thickness on Venus from Magellan Gravity and Topography

NASA Technical Reports Server (NTRS)

Johnson, C. L.

2005-01-01

This final report summarizes work carried out during my PGG funding for the period 3/1/02-2/28/05. Research under this award has focused on the areas described below and is represented in the publications list, invited departmental lectures and presentations at professional meetings. The grant has provided partial support for 1 graduate student, Renee Bulow, and provided 1 month per year of my summer salary. The linking theme of the research performed under this award is the manifestation of the thermal history of terrestrial planetary bodies through the existence and evolution of internally-generated magnetic fields (martian magnetism research, and beginnings of lunar magnetism research), mantle dynamical processes and their resulting surface expression (studies of Venusian coronae task) and the crust and upper mantle structure of a planetary body (lunar seismic structure task). The investigations build upon and extend my previous work supported by the PGG program.

Toward a comprehensive taxonomy of human motives

PubMed Central

Talevich, Jennifer R.; Walsh, David A.; Iyer, Ravi; Chopra, Gurveen

2017-01-01

A major success in personality has been the development of a consensual structure of traits. However, much less progress has been made on the structure of an equally important aspect of human psychology: motives. We present an empirically and theoretically structured hierarchical taxonomy of 161 motives gleaned from a literature review from McDougall to the present and based on the cluster analysis of similarity judgments among these 161 motives, a broader sampling of motives than previous work. At the broadest level were: Meaning, Communion, and Agency. These divided into nine clusters: Morality & Virtue, Religion & Spirituality, Self-Actualization, Avoidance, Social Relating, Family, Health, Mastery & Competence, and Financial & Occupational Success. Each divided into more concrete clusters to form 5 levels. We discuss contributions to research on motives, especially recent work on goal systems, and the aiding of communication and systematization of research. Finally, we compare the taxonomy to other motive organizations. PMID:28231252

Information Filtering via Heterogeneous Diffusion in Online Bipartite Networks.

PubMed

Zhang, Fu-Guo; Zeng, An

2015-01-01

The rapid expansion of Internet brings us overwhelming online information, which is impossible for an individual to go through all of it. Therefore, recommender systems were created to help people dig through this abundance of information. In networks composed by users and objects, recommender algorithms based on diffusion have been proven to be one of the best performing methods. Previous works considered the diffusion process from user to object, and from object to user to be equivalent. We show in this work that it is not the case and we improve the quality of the recommendation by taking into account the asymmetrical nature of this process. We apply this idea to modify the state-of-the-art recommendation methods. The simulation results show that the new methods can outperform these existing methods in both recommendation accuracy and diversity. Finally, this modification is checked to be able to improve the recommendation in a realistic case.

Does Leaders' Health (and Work-Related Experiences) Affect their Evaluation of Followers' Stress?

PubMed Central

Giorgi, Gabriele; Mancuso, Serena; Fiz Perez, Francisco Javier; Montani, Francesco; Courcy, Francois; Arcangeli, Giulio

2015-01-01

Background Stressed workers suffer from severe health problems which appear to have increased. Poor leadership is especially considered a source of stress. Indeed, supervisors might perceive their subordinates to be similar to them as far as stress is concerned and this might more widespread in organizations than previously thought. Methods The present research investigates the relationships between leaders' health, in terms of work-related stress, mental health, and workplace bullying and their evaluation of subordinates' stress. Five regression models were formulated to test our hypothesis. This is a cross-sectional study among 261 Italian leaders, using supervisor self-assessment and leaders' assessments of their subordinates. Results Leaders' health was related to their evaluation of staff stress. Job demand, lack of job control, and lack of support by colleagues and supervisors evaluated in their subordinates were particularly associated with the leaders' own health. Conclusion Implications for developing healthy leaders are finally discussed. PMID:26929835

Supervisory control based on minimal cuts and Petri net sub-controllers coordination

NASA Astrophysics Data System (ADS)

Rezig, Sadok; Achour, Zied; Rezg, Nidhal; Kammoun, Mohamed-Ali

2016-10-01

This paper addresses the synthesis of Petri net (PN) controller for the forbidden state transition problem with a new utilisation of the theory of regions. Moreover, as any method of control synthesis based on a reachability graph, the theory of regions suffers from the combinatorial explosion problem. The proposed work minimises the number of equations in the linear system of theory of regions and therefore one can reduce the computation time. In this paper, two different approaches are proposed to select minimal cuts in the reachability graph in order to synthesise a PN controller. Thanks to a switch from one cut to another, one can activate and deactivate the corresponding PNcontroller. An application is implemented in a flexible manufacturing system to illustrate the present method. Finally, comparison with previous works with experimental results in obtaining a maximally permissive controller is presented.

Semi-supervised learning via regularized boosting working on multiple semi-supervised assumptions.

PubMed

Chen, Ke; Wang, Shihai

2011-01-01

Semi-supervised learning concerns the problem of learning in the presence of labeled and unlabeled data. Several boosting algorithms have been extended to semi-supervised learning with various strategies. To our knowledge, however, none of them takes all three semi-supervised assumptions, i.e., smoothness, cluster, and manifold assumptions, together into account during boosting learning. In this paper, we propose a novel cost functional consisting of the margin cost on labeled data and the regularization penalty on unlabeled data based on three fundamental semi-supervised assumptions. Thus, minimizing our proposed cost functional with a greedy yet stagewise functional optimization procedure leads to a generic boosting framework for semi-supervised learning. Extensive experiments demonstrate that our algorithm yields favorite results for benchmark and real-world classification tasks in comparison to state-of-the-art semi-supervised learning algorithms, including newly developed boosting algorithms. Finally, we discuss relevant issues and relate our algorithm to the previous work.

IUE data reduction: Wavelength determinations and line identifications using a VAX/750 computer

NASA Technical Reports Server (NTRS)

Davidson, J. P.; Bord, D. J.

1982-01-01

A fully automated, interactive system for determining the wavelengths of features in extracted IUE spectra is described. Wavelengths are recorded from video displays of expanded plots of individual orders using a movable cursor, and then corrected for IUE wavelength scale errors. The estimated accuracy of an individual wavelength in the final tabulation is 0.050 A. Such lists are ideally suited for line identification work using the method of wavelength coincidence statistics (WCS). The results of WCS studies of the ultraviolet spectra of the chemically peculiar (CP) stars iota Coronae Borealis and kappa Camcri. Aside from confirming a number of previously reported aspects of the abundance patterns in these stars, the searches produced some interesting, new discoveries, notably the presence of Hf in the spectrum of kappa Camcri. The implications of this work for theories designed to account for anomalous abundances in chemically peculiar stars are discussed.

IUE data reduction: Wavelength determinations and line identifications using a VAX/750 computer

NASA Astrophysics Data System (ADS)

Davidson, J. P.; Bord, D. J.

A fully automated, interactive system for determining the wavelengths of features in extracted IUE spectra is described. Wavelengths are recorded from video displays of expanded plots of individual orders using a movable cursor, and then corrected for IUE wavelength scale errors. The estimated accuracy of an individual wavelength in the final tabulation is 0.050 A. Such lists are ideally suited for line identification work using the method of wavelength coincidence statistics (WCS). The results of WCS studies of the ultraviolet spectra of the chemically peculiar (CP) stars iota Coronae Borealis and kappa Camcri. Aside from confirming a number of previously reported aspects of the abundance patterns in these stars, the searches produced some interesting, new discoveries, notably the presence of Hf in the spectrum of kappa Camcri. The implications of this work for theories designed to account for anomalous abundances in chemically peculiar stars are discussed.

Design and implementation of practical bidirectional texture function measurement devices focusing on the developments at the University of Bonn.

PubMed

Schwartz, Christopher; Sarlette, Ralf; Weinmann, Michael; Rump, Martin; Klein, Reinhard

2014-04-28

Understanding as well as realistic reproduction of the appearance of materials play an important role in computer graphics, computer vision and industry. They enable applications such as digital material design, virtual prototyping and faithful virtual surrogates for entertainment, marketing, education or cultural heritage documentation. A particularly fruitful way to obtain the digital appearance is the acquisition of reflectance from real-world material samples. Therefore, a great variety of devices to perform this task has been proposed. In this work, we investigate their practical usefulness. We first identify a set of necessary attributes and establish a general categorization of different designs that have been realized. Subsequently, we provide an in-depth discussion of three particular implementations by our work group, demonstrating advantages and disadvantages of different system designs with respect to the previously established attributes. Finally, we survey the existing literature to compare our implementation with related approaches.

Defining Outcome Measures for Psoriasis: The IDEOM Report from the GRAPPA 2016 Annual Meeting.

PubMed

Callis Duffin, Kristina; Gottlieb, Alice B; Merola, Joseph F; Latella, John; Garg, Amit; Armstrong, April W

2017-05-01

The International Dermatology Outcome Measures (IDEOM) psoriasis working group was established to develop core domains and measurements sets for psoriasis clinical trials and ultimately clinical practice. At the 2016 annual meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis, the IDEOM psoriasis group presented an overview of its progress toward developing this psoriasis core domain set. First, it summarized the February 2016 meeting of all involved with the IDEOM, highlighting patient and payer perspectives on outcome measures. Second, the group presented an overview of the consensus process for developing the core domain set for psoriasis, including previous literature reviews, nominal group exercises, and meeting discussions. Future plans include the development of working groups to review candidate measures for at least 2 of the domains, including primary pathophysiologic manifestations and patient-reported outcomes, and Delphi surveys to gain consensus on the final psoriasis core domain set.

37 CFR 211.4 - Registration of claims of protection in mask works.

Code of Federal Regulations, 2011 CFR

2011-07-01

... version of a mask work fixed in an intermediate or final form of any semiconductor chip product. However... registration per work, owners of mask works in final forms of semiconductor chip products that are produced by... commercially exploited: All original mask work elements fixed in a particular form of a semiconductor chip...

Work-Related Eye Injuries: A Relevant Health Problem. Main Epidemiological Data from a Highly-Industrialized Area of Northern Italy.

PubMed

Gobba, Fabriziomaria; Dall'Olio, Enrico; Modenese, Alberto; De Maria, Michele; Campi, Luca; Cavallini, Gian Maria

2017-06-06

The province of Modena is one of the most industrialized areas of Northern Italy. The medical records of the Ophthalmological Emergency Department (OED) of Modena University Hospital were studied: there were 13,470 OED accesses in 2014 and in 754 cases that an occupational eye injury occurred. The frequency of work-related eye injuries (3‰) was lower compared to other published studies, but the absolute number is still relevant, showing the need for more adequate prevention, especially in metal work, construction work, and agriculture, where the worst prognoses were observed. Intervention programs must be implemented as early as possible in the working life, considering that the frequency in younger workers is about double that of the oldest age class (3.5‰ vs. 1.8‰), and special attention should also be given to foreigners, who have a 50% higher injury risk. Furthermore, the planning of specific interventions for eye-injured workers may be useful, considering that a previous injury does not appear to encourage the adoption of preventive interventions, and a subgroup of eye-injured workers have a potential risk for new injuries. Finally, the data presented here indicates how OED records, integrated with specific occupational information, can be applied for studies on work-related eye injuries.

Medical Image Processing Server applied to Quality Control of Nuclear Medicine.

NASA Astrophysics Data System (ADS)

Vergara, C.; Graffigna, J. P.; Marino, E.; Omati, S.; Holleywell, P.

2016-04-01

This paper is framed within the area of medical image processing and aims to present the process of installation, configuration and implementation of a processing server of medical images (MIPS) in the Fundación Escuela de Medicina Nuclear located in Mendoza, Argentina (FUESMEN). It has been developed in the Gabinete de Tecnologia Médica (GA.TE.ME), Facultad de Ingeniería-Universidad Nacional de San Juan. MIPS is a software that using the DICOM standard, can receive medical imaging studies of different modalities or viewing stations, then it executes algorithms and finally returns the results to other devices. To achieve the objectives previously mentioned, preliminary tests were conducted in the laboratory. More over, tools were remotely installed in clinical enviroment. The appropiate protocols for setting up and using them in different services were established once defined those suitable algorithms. Finally, it’s important to focus on the implementation and training that is provided in FUESMEN, using nuclear medicine quality control processes. Results on implementation are exposed in this work.

Evaluative studies in nuclear medicine research: positron computed tomography assessment. Final report, January 1, 1982-December 31, 1982

DOE Office of Scientific and Technical Information (OSTI.GOV)

Potchen, E.J.; Harris, G.I.; Gift, D.A. Reinhard, D.K.

Results are reported of the final phase of the study effort generally titled Evaluative Studies in Nuclear Medicine Research. The previous work is reviewed and extended to an assessment providing perspectives on medical applications of positron emission tomographic (PET) systems, their technological context, and the related economic and marketing environment. Methodologies developed and used in earlier phases of the study were continued, but specifically extended to include solicitation of opinion from commercial organizations deemed to be potential developers, manufacturers and marketers of PET systems. Several factors which influence the demand for clinical uses of PET are evaluated and discussed. Themore » recent Federal funding of applied research with PET systems is found to be a necessary and encouraging event toward a determination that PET either is a powerful research tool limited to research, or whether it also presents major clinical utility. A comprehensive, updated bibliography of current literature related to the development, applications and economic considerations of PET technology is appended.« less

The kinetics of polyurethane structural foam formation: Foaming and polymerization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rao, Rekha R.; Mondy, Lisa A.; Long, Kevin N.

We are developing kinetic models to understand the manufacturing of polymeric foams, which evolve from low viscosity Newtonian liquids, to bubbly liquids, finally producing solid foam. Closed-form kinetics are formulated and parameterized for PMDI-10, a fast curing polyurethane, including polymerization and foaming. PMDI- 10 is chemically blown, where water and isocyanate react to form carbon dioxide. The isocyanate reacts with polyol in a competing reaction, producing polymer. Our approach is unique, though it builds on our previous work and the polymerization literature. This kinetic model follows a simplified mathematical formalism that decouples foaming and curing, including an evolving glass transitionmore » temperature to represent vitrification. This approach is based on IR, DSC, and volume evolution data, where we observed that the isocyanate is always in excess and does not affect the kinetics. Finally, the kinetics are suitable for implementation into a computational fluid dynamics framework, which will be explored in subsequent papers.« less

The kinetics of polyurethane structural foam formation: Foaming and polymerization

DOE PAGES

Rao, Rekha R.; Mondy, Lisa A.; Long, Kevin N.; ...

2017-02-15

We are developing kinetic models to understand the manufacturing of polymeric foams, which evolve from low viscosity Newtonian liquids, to bubbly liquids, finally producing solid foam. Closed-form kinetics are formulated and parameterized for PMDI-10, a fast curing polyurethane, including polymerization and foaming. PMDI- 10 is chemically blown, where water and isocyanate react to form carbon dioxide. The isocyanate reacts with polyol in a competing reaction, producing polymer. Our approach is unique, though it builds on our previous work and the polymerization literature. This kinetic model follows a simplified mathematical formalism that decouples foaming and curing, including an evolving glass transitionmore » temperature to represent vitrification. This approach is based on IR, DSC, and volume evolution data, where we observed that the isocyanate is always in excess and does not affect the kinetics. Finally, the kinetics are suitable for implementation into a computational fluid dynamics framework, which will be explored in subsequent papers.« less

Final Report - Few-Body Studies Using Electromagnetic Interactions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Norum, Blaine

The work discussed here is an extension of work previously funded by U.S. Department of Energy Grant DE-FG02-97ER41025. Measurements of charged pion photoproduction from deuterium using the Laser Electron Gamma Source (LEGS) at the Brookhaven National Laboratory previously made by us, as members of the LEGS Collaboration, resulted in the most interesting result of two decades of work. By measuring the production of a charged pion (π +) in coincidence with an emitted photon we observed structures in the residual two-nucleon system. These indicated the existence of rare, long-lived states not explicable by standard nuclear theory; they suggested a setmore » of configurations not explicable in terms of a nucleon-nucleon pair. The existence of such “exotic” structures has formed the foundation for most of the work that has ensued. Several measurements at various laboratories have supported, but not proved, the existence of these exotic states. The rarity of these states made their existence undetectable in most previous measurements. Only by observing characteristic signatures of such states (i.e., decay photons), by using very specific kinematics which isolate certain reaction products, or by measuring polarization-dependent observables. During the period of this grant we pursued and made progress on the development of experiments to be performed at the High Intensity Gamma Source (HIGS) of the Tri Universities Nuclear Laboratory (TUNL). Our understanding of photon- and electron-induced nuclear reactions depends on understanding of the basic electron and photon interaction. Recently, the issue of two-photon contributions has arisen in the context of deeply inelastic electron scattering. One way to address this is to measure asymmetries in the Bethe-Heitler ee process. We also made progress in developing the detectors required to measure these asymmetries at HIGS. During the last several years the apparent discrepancy between the size of the proton as measured using electrons and that as measured using muons has received a great deal of attention. Working with colleagues at the Jefferson Laboratory (JLAB) we showed that the apparent discrepancy was almost surely the result of mistakes in the statistical analysis of electron scattering data, that there is almost surely no discrepancy.« less

Report of the CCQM-K97: measurement of arsenobetaine standard solution and arsenobetaine content in fish tissue (tunafish)

NASA Astrophysics Data System (ADS)

Ma, L. D.; Wang, J.; WEI, C.; Kuroiwa, T.; Narukawa, T.; Ito, N.; HIOKI, A.; CHIBA, K.; Yim, Y. H.; Lee, K. S.; Lim, Y. R.; Turk, G. C.; Davis, C. W.; Mester, Z.; Yang, L.; McCooeye, M.; Maxwell, P.; Cankur, O.; Tokman, N.; Coskun, F. G.

2017-01-01

The CCQM-K97 key comparison was organized by the inorganic analysis working group (IAWG) of CCQM as a follow-up to completed pilot study CCQM-P96 and P96.1 to test the abilities of the national metrology institutes to accurately quantitate the mass fraction of arsenobetaine (AsB) in standard solution and in fish tissue. A pilot study CCQM-P133 was parallelized with this key comparison. National Institute of Metrology (NIM), China and National Metrology Institute of Japan (NMIJ) acted as the coordinating laboratories. Six NMIs participated in CCQM-K97 and two institutes participated in CCQM-P133, and all of them submitted the results. Some NMIs submitted more than one results by different methods. The results were in excellent agreement with each other, and obviously better than those of previous P96 and P96.1. Therefore the calibrant which each NMI used was comparable. It shows that the capabilities of some of the participants have been improved after the previous pilot studies. Main text To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCQM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

Normative data for idiomatic expressions.

PubMed

Nordmann, Emily; Jambazova, Antonia A

2017-02-01

Idiomatic expressions such as kick the bucket or go down a storm can differ on a number of internal features, such as familiarity, meaning, literality, and decomposability, and these types of features have been the focus of a number of normative studies. In this article, we provide normative data for a set of Bulgarian idioms and their English translations, and by doing so replicate in a Slavic language the relationships between the ratings previously found in Romance and Germanic languages. Additionally, we compared whether collecting these types of ratings in between-subjects or within-subjects designs affects the data and the conclusions drawn, and found no evidence that design type affects the final outcome. Finally, we present the results of a meta-analysis that summarizes the relationships found across the literature. As in many previous individual studies, we found that familiarity correlates with a number of other features; however, such studies have shown conflicting results concerning literality and decomposability ratings. The meta-analysis revealed reliable relationships of decomposability with a number of other measures, such as familiarity, meaning, and predictability. Conversely, literality was shown to have little to no relationship with any of the other subjective ratings. The implications for these relationships in the context of the wider experimental literature are discussed, with a particular focus on the importance of attaining familiarity ratings for each sample of participants in experimental work.

Mass measurement using energy spectra in three-body decays

DOE PAGES

Agashe, Kaustubh; Franceschini, Roberto; Kim, Doojin; ...

2016-05-24

In previous works we have demonstrated how the energy distribution of massless decay products in two body decays can be used to measure the mass of decaying particles. In this study, we show how such results can be generalized to the case of multi-body decays. The key ideas that allow us to deal with multi-body final states are an extension of our previous results to the case of massive decay products and the factorization of the multi-body phase space. The mass measurement strategy that we propose is distinct from alternative methods because it does not require an accurate reconstruction ofmore » the entire event, as it does not involve, for instance, the missing transverse momentum, but rather requires measuring only the visible decay products of the decay of interest. To demonstrate the general strategy, we study a supersymmetric model wherein pair-produced gluinos each decay to a stable neutralino and a bottom quark-antiquark pair via an off -shell bottom squark. The combinatorial background stemming from the indistinguishable visible final states on both decay sides can be treated by an “event mixing” technique, the performance of which is discussed in detail. In conclusion, taking into account dominant backgrounds, we are able to show that the mass of the gluino and, in favorable cases, that of the neutralino can be determined by this mass measurement strategy.« less

Influence of the set-up on the recording of diffractive optical elements into photopolymers

NASA Astrophysics Data System (ADS)

Gallego, S.; Fernández, R.; Márquez, A.; Neipp, C.; Beléndez, A.; Pascual, I.

2014-05-01

Photopolymers are often used as a base of holographic memories displays. Recently the capacity of photopolymers to record diffractive optical elements (DOE's) has been demonstrated. To fabricate diffractive optical elements we use a hybrid setup that is composed by three different parts: LCD, optical system and the recording material. The DOE pattern is introduced by a liquid crystal display (LCD) working in the amplitude only mode to work as a master to project optically the DOE onto the recording material. The main advantage of this display is that permit us modify the DOE automatically, we use the electronics of the video projector to send the voltage to the pixels of the LCD. The LCD is used in the amplitude-mostly modulation regime by proper orientation of the external polarizers (P); then the pattern is imaged onto the material with an increased spatial frequency (a demagnifying factor of 2) by the optical system. The use of the LCD allows us to change DOE recorded in the photopolymer without moving any mechanical part of the set-up. A diaphragm is placed in the focal plane of the relay lens so as to eliminate the diffraction orders produced by the pixelation of the LCD. It can be expected that the final pattern imaged onto the recording material will be low filtered due to the finite aperture of the imaging system and especially due to the filtering process produced by the diaphragm. In this work we analyze the effect of the visibility achieved with the LCD and the high frequency cut-off due to the diaphragm in the final DOE recorded into the photopolymer. To simulate the recording we have used the fitted values parameters obtained for PVA/AA based photopolymers and the 3 dimensional models presented in previous works.

Development and validation of a web-based questionnaire for surveying the health and working conditions of high-performance marine craft populations

PubMed Central

de Alwis, Manudul Pahansen; Lo Martire, Riccardo; Äng, Björn O; Garme, Karl

2016-01-01

Background High-performance marine craft crews are susceptible to various adverse health conditions caused by multiple interactive factors. However, there are limited epidemiological data available for assessment of working conditions at sea. Although questionnaire surveys are widely used for identifying exposures, outcomes and associated risks with high accuracy levels, until now, no validated epidemiological tool exists for surveying occupational health and performance in these populations. Aim To develop and validate a web-based questionnaire for epidemiological assessment of occupational and individual risk exposure pertinent to the musculoskeletal health conditions and performance in high-performance marine craft populations. Method A questionnaire for investigating the association between work-related exposure, performance and health was initially developed by a consensus panel under four subdomains, viz. demography, lifestyle, work exposure and health and systematically validated by expert raters for content relevance and simplicity in three consecutive stages, each iteratively followed by a consensus panel revision. The item content validity index (I-CVI) was determined as the proportion of experts giving a rating of 3 or 4. The scale content validity index (S-CVI/Ave) was computed by averaging the I-CVIs for the assessment of the questionnaire as a tool. Finally, the questionnaire was pilot tested. Results The S-CVI/Ave increased from 0.89 to 0.96 for relevance and from 0.76 to 0.94 for simplicity, resulting in 36 items in the final questionnaire. The pilot test confirmed the feasibility of the questionnaire. Conclusions The present study shows that the web-based questionnaire fulfils previously published validity acceptance criteria and is therefore considered valid and feasible for the empirical surveying of epidemiological aspects among high-performance marine craft crews and similar populations. PMID:27324717

Developing measures of food and nutrition security within an Australian context.

PubMed

Archer, Claire; Gallegos, Danielle; McKechnie, Rebecca

2017-10-01

To develop a measure of food and nutrition security for use among an Australian population that measures all pillars of food security and to establish its content validity. The study consisted of two phases. Phase 1 involved focus groups with experts working in the area of food security. Data were assessed using content analysis and results informed the development of a draft tool. Phase 2 consisted of a series of three online surveys using the Delphi technique. Findings from each survey were used to establish content validity and progressively modify the tool until consensus was reached for all items. Australia. Phase 1 focus groups involved twenty-five experts working in the field of food security, who were attending the Dietitians Association of Australia National Conference, 2013. Phase 2 included twenty-five experts working in food security, who were recruited via email. Findings from Phase 1 supported the need for an Australian-specific tool and highlighted the failure of current tools to measure across all pillars of food security. Participants encouraged the inclusion of items to measure barriers to food acquisition and the previous single item to enable comparisons with previous data. Phase 2 findings informed the selection and modification of items for inclusion in the final tool. The results led to the development of a draft tool to measure food and nutrition security, and supported its content validity. Further research is needed to validate the tool among the Australian population and to establish inter- and intra-rater reliability.

Ontogenetic differences of herbivory on woody and herbaceous plants: a meta-analysis demonstrating unique effects of herbivory on the young and the old, the slow and the fast.

PubMed

Massad, Tara Joy

2013-05-01

The effect of herbivory on plant performance is the subject of a large number of ecological studies, and plant responses to herbivory range from reduced reproduction to overcompensation. Because plant defenses, stored resources, and allocation demands change throughout a plant's lifetime, it can be hypothesized the effects of herbivory also vary with development. The present work extends previous analyses to incorporate hundreds of studies in a new meta-analysis addressing this topic. Herbivores had an overall negative effect on plant growth and reproduction, and, in contrast to a previous meta-analysis, this work shows the timing of herbivory is relevant. Differences in the effects of herbivory between life stages existed for woody plant reproduction and perennial herb growth. In addition, tree and shrub growth was reduced by herbivore damage at early ontogenetic stages, and perennial herb reproduction was limited by adult stage herbivory. These results partially support the continuum of an ontogenetic response model. Finally, consideration of this synthesis in conjunction with other work led to the conclusion that different plant groups optimize their defense investments in unique ways. Slow-growing plants may strongly chemically defend young tissues, supporting the plant-age hypothesis, because early herbivory is detrimental to growth. Faster-growing herbs may invest more in antiherbivore defense when they are older, supporting the growth-differentiation balance hypothesis, because later herbivory limits their reproduction.

Numerical optimization of conical flow waveriders including detailed viscous effects

NASA Technical Reports Server (NTRS)

Bowcutt, Kevin G.; Anderson, John D., Jr.; Capriotti, Diego

1987-01-01

A family of optimized hypersonic waveriders is generated and studied wherein detailed viscous effects are included within the optimization process itself. This is in contrast to previous optimized waverider work, wherein purely inviscid flow is used to obtain the waverider shapes. For the present waveriders, the undersurface is a streamsurface of an inviscid conical flowfield, the upper surface is a streamsurface of the inviscid flow over a tapered cylinder (calculated by the axisymmetric method of characteristics), and the viscous effects are treated by integral solutions of the boundary layer equations. Transition from laminar to turbulent flow is included within the viscous calculations. The optimization is carried out using a nonlinear simplex method. The resulting family of viscous hypersonic waveriders yields predicted high values of lift/drag, high enough to break the L/D barrier based on experience with other hypersonic configurations. Moreover, the numerical optimization process for the viscous waveriders results in distinctly different shapes compared to previous work with inviscid-designed waveriders. Also, the fine details of the viscous solution, such as how the shear stress is distributed over the surface, and the location of transition, are crucial to the details of the resulting waverider geometry. Finally, the moment coefficient variations and heat transfer distributions associated with the viscous optimized waveriders are studied.

Smoke detection using GLCM, wavelet, and motion

NASA Astrophysics Data System (ADS)

Srisuwan, Teerasak; Ruchanurucks, Miti

2014-01-01

This paper presents a supervised smoke detection method that uses local and global features. This framework integrates and extends notions of many previous works to generate a new comprehensive method. First chrominance detection is used to screen areas that are suspected to be smoke. For these areas, local features are then extracted. The features are among homogeneity of GLCM and energy of wavelet. Then, global feature of motion of the smoke-color areas are extracted using a space-time analysis scheme. Finally these features are used to train an artificial intelligent. Here we use neural network, experiment compares importance of each feature. Hence, we can really know which features among those used by many previous works are really useful. The proposed method outperforms many of the current methods in the sense of correctness, and it does so in a reasonable computation time. It even has less limitation than conventional smoke sensors when used in open space. Best method for the experimental results is to use all the mentioned features as expected, to insure which is the best experiment result can be achieved. The achieved with high accuracy of result expected output is high value of true positive and low value of false positive. And show that our algorithm has good robustness for smoke detection.

Unified Models of Turbulence and Nonlinear Wave Evolution in the Extended Solar Corona and Solar Wind

NASA Technical Reports Server (NTRS)

Wagner, William (Technical Monitor); Cranmer, Steven R.

2005-01-01

The paper discusses the following: 1. No-cost Extension. The no-cost extension is required to complete the work on the unified model codes (both hydrodynamic and kinetic Monte Carlo) as described in the initial proposal and previous annual reports. 2. Scientific Accomplishments during the Report Period. We completed a comprehensive model of Alfvtn wave reflection that spans the full distance from the photosphere to the distant heliosphere. 3. Comparison of Accomplishments with Proposed Goals. The proposal contained two specific objectives for Year 3: (1) to complete the unified model code, and (2) to apply it to various kinds of coronal holes (and polar plumes within coronal holes). Although the anticipated route toward these two final goals has changed (see accomplishments 2a and 2b above), they remain the major milestones for the extended period of performance. Accomplishments la and IC were necessary prerequisites for the derivation of "physically relevant transport and mode-coupling terms" for the unified model codes (as stated in the proposal Year 3 goals). We have fulfilled the proposed "core work" to study 4 general types of physical processes; in previous years we studied turbulence, mode coupling (Le., non-WKB reflection), and kinetic wave damping, and accomplishment lb provides the fourth topic: nonlinear steepening.

Shell extracts from the marine bivalve Pecten maximus regulate the synthesis of extracellular matrix in primary cultured human skin fibroblasts.

PubMed

Latire, Thomas; Legendre, Florence; Bigot, Nicolas; Carduner, Ludovic; Kellouche, Sabrina; Bouyoucef, Mouloud; Carreiras, Franck; Marin, Frédéric; Lebel, Jean-Marc; Galéra, Philippe; Serpentini, Antoine

2014-01-01

Mollusc shells are composed of more than 95% calcium carbonate and less than 5% of an organic matrix consisting mostly of proteins, glycoproteins and polysaccharides. Previous studies have elucidated the biological activities of the shell matrices from bivalve molluscs on skin, especially on the expression of the extracellular matrix components of fibroblasts. In this work, we have investigated the potential biological activities of shell matrix components extracted from the shell of the scallop Pecten maximus on human fibroblasts in primary culture. Firstly, we demonstrated that shell matrix components had different effects on general cellular activities. Secondly, we have shown that the shell matrix components stimulate the synthesis of type I and III collagens, as well as that of sulphated GAGs. The increased expression of type I collagen is likely mediated by the recruitment of transactivating factors (Sp1, Sp3 and human c-Krox) in the -112/-61 bp COL1A1 promoter region. Finally, contrarily to what was obtained in previous works, we demonstrated that the scallop shell extracts have only a small effect on cell migration during in vitro wound tests and have no effect on cell proliferation. Thus, our research emphasizes the potential use of shell matrix of Pecten maximus for dermo-cosmetic applications.

A Biologically Inspired Computational Model of Basal Ganglia in Action Selection

PubMed Central

Baston, Chiara

2015-01-01

The basal ganglia (BG) are a subcortical structure implicated in action selection. The aim of this work is to present a new cognitive neuroscience model of the BG, which aspires to represent a parsimonious balance between simplicity and completeness. The model includes the 3 main pathways operating in the BG circuitry, that is, the direct (Go), indirect (NoGo), and hyperdirect pathways. The main original aspects, compared with previous models, are the use of a two-term Hebb rule to train synapses in the striatum, based exclusively on neuronal activity changes caused by dopamine peaks or dips, and the role of the cholinergic interneurons (affected by dopamine themselves) during learning. Some examples are displayed, concerning a few paradigmatic cases: action selection in basal conditions, action selection in the presence of a strong conflict (where the role of the hyperdirect pathway emerges), synapse changes induced by phasic dopamine, and learning new actions based on a previous history of rewards and punishments. Finally, some simulations show model working in conditions of altered dopamine levels, to illustrate pathological cases (dopamine depletion in parkinsonian subjects or dopamine hypermedication). Due to its parsimonious approach, the model may represent a straightforward tool to analyze BG functionality in behavioral experiments. PMID:26640481

The new final Clinical Skills examination in human medicine in Switzerland: Essential steps of exam development, implementation and evaluation, and central insights from the perspective of the national Working Group

PubMed Central

Berendonk, Christoph; Schirlo, Christian; Balestra, Gianmarco; Bonvin, Raphael; Feller, Sabine; Huber, Philippe; Jünger, Ernst; Monti, Matteo; Schnabel, Kai; Beyeler, Christine; Guttormsen, Sissel; Huwendiek, Sören

2015-01-01

Objective: Since 2011, the new national final examination in human medicine has been implemented in Switzerland, with a structured clinical-practical part in the OSCE format. From the perspective of the national Working Group, the current article describes the essential steps in the development, implementation and evaluation of the Federal Licensing Examination Clinical Skills (FLE CS) as well as the applied quality assurance measures. Finally, central insights gained from the last years are presented. Methods: Based on the principles of action research, the FLE CS is in a constant state of further development. On the foundation of systematically documented experiences from previous years, in the Working Group, unresolved questions are discussed and resulting solution approaches are substantiated (planning), implemented in the examination (implementation) and subsequently evaluated (reflection). The presented results are the product of this iterative procedure. Results: The FLE CS is created by experts from all faculties and subject areas in a multistage process. The examination is administered in German and French on a decentralised basis and consists of twelve interdisciplinary stations per candidate. As important quality assurance measures, the national Review Board (content validation) and the meetings of the standardised patient trainers (standardisation) have proven worthwhile. The statistical analyses show good measurement reliability and support the construct validity of the examination. Among the central insights of the past years, it has been established that the consistent implementation of the principles of action research contributes to the successful further development of the examination. Conclusion: The centrally coordinated, collaborative-iterative process, incorporating experts from all faculties, makes a fundamental contribution to the quality of the FLE CS. The processes and insights presented here can be useful for others planning a similar undertaking. PMID:26483853

Method: automatic segmentation of mitochondria utilizing patch classification, contour pair classification, and automatically seeded level sets

PubMed Central

2012-01-01

Background While progress has been made to develop automatic segmentation techniques for mitochondria, there remains a need for more accurate and robust techniques to delineate mitochondria in serial blockface scanning electron microscopic data. Previously developed texture based methods are limited for solving this problem because texture alone is often not sufficient to identify mitochondria. This paper presents a new three-step method, the Cytoseg process, for automated segmentation of mitochondria contained in 3D electron microscopic volumes generated through serial block face scanning electron microscopic imaging. The method consists of three steps. The first is a random forest patch classification step operating directly on 2D image patches. The second step consists of contour-pair classification. At the final step, we introduce a method to automatically seed a level set operation with output from previous steps. Results We report accuracy of the Cytoseg process on three types of tissue and compare it to a previous method based on Radon-Like Features. At step 1, we show that the patch classifier identifies mitochondria texture but creates many false positive pixels. At step 2, our contour processing step produces contours and then filters them with a second classification step, helping to improve overall accuracy. We show that our final level set operation, which is automatically seeded with output from previous steps, helps to smooth the results. Overall, our results show that use of contour pair classification and level set operations improve segmentation accuracy beyond patch classification alone. We show that the Cytoseg process performs well compared to another modern technique based on Radon-Like Features. Conclusions We demonstrated that texture based methods for mitochondria segmentation can be enhanced with multiple steps that form an image processing pipeline. While we used a random-forest based patch classifier to recognize texture, it would be possible to replace this with other texture identifiers, and we plan to explore this in future work. PMID:22321695

BEST (Better Educational Skills Training). Final Report.

ERIC Educational Resources Information Center

Vermont Adult Learning, Rutland.

This document contains a final report, evaluation report, and materials from the Better Educational Skills Training (BEST) workplace literacy program in Vermont. The seven-page final report describes program components: (1) expanding and institutionalizing the workplace literacy program developed through two previous national workplace literacy…

Genome-wide study of the adaptation of Saccharomyces cerevisiae to the early stages of wine fermentation.

PubMed

Novo, Maite; Mangado, Ana; Quirós, Manuel; Morales, Pilar; Salvadó, Zoel; Gonzalez, Ramon

2013-01-01

This work was designed to identify yeast cellular functions specifically affected by the stress factors predominating during the early stages of wine fermentation, and genes required for optimal growth under these conditions. The main experimental method was quantitative fitness analysis by means of competition experiments in continuous culture of whole genome barcoded yeast knockout collections. This methodology allowed the identification of haploinsufficient genes, and homozygous deletions resulting in growth impairment in synthetic must. However, genes identified as haploproficient, or homozygous deletions resulting in fitness advantage, were of little predictive power concerning optimal growth in this medium. The relevance of these functions for enological performance of yeast was assessed in batch cultures with single strains. Previous studies addressing yeast adaptation to winemaking conditions by quantitative fitness analysis were not specifically focused on the proliferative stages. In some instances our results highlight the importance of genes not previously linked to winemaking. In other cases they are complementary to those reported in previous studies concerning, for example, the relevance of some genes involved in vacuolar, peroxisomal, or ribosomal functions. Our results indicate that adaptation to the quickly changing growth conditions during grape must fermentation require the function of different gene sets in different moments of the process. Transport processes and glucose signaling seem to be negatively affected by the stress factors encountered by yeast in synthetic must. Vacuolar activity is important for continued growth during the transition to stationary phase. Finally, reduced biogenesis of peroxisomes also seems to be advantageous. However, in contrast to what was described for later stages, reduced protein synthesis is not advantageous for the early (proliferative) stages of the fermentation process. Finally, we found adenine and lysine to be in short supply for yeast growth in some natural grape musts.

Optimal lattice-structured materials

DOE PAGES

Messner, Mark C.

2016-07-09

This paper describes a method for optimizing the mesostructure of lattice-structured materials. These materials are periodic arrays of slender members resembling efficient, lightweight macroscale structures like bridges and frame buildings. Current additive manufacturing technologies can assemble lattice structures with length scales ranging from nanometers to millimeters. Previous work demonstrates that lattice materials have excellent stiffness- and strength-to-weight scaling, outperforming natural materials. However, there are currently no methods for producing optimal mesostructures that consider the full space of possible 3D lattice topologies. The inverse homogenization approach for optimizing the periodic structure of lattice materials requires a parameterized, homogenized material model describingmore » the response of an arbitrary structure. This work develops such a model, starting with a method for describing the long-wavelength, macroscale deformation of an arbitrary lattice. The work combines the homogenized model with a parameterized description of the total design space to generate a parameterized model. Finally, the work describes an optimization method capable of producing optimal mesostructures. Several examples demonstrate the optimization method. One of these examples produces an elastically isotropic, maximally stiff structure, here called the isotruss, that arguably outperforms the anisotropic octet truss topology.« less

Institute for High Heat Flux Removal (IHHFR). Phases I, II, and III

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boyd, Ronald D.

2014-08-31

The IHHFR focused on interdisciplinary applications as it relates to high heat flux engineering issues and problems which arise due to engineering systems being miniaturized, optimized, or requiring increased high heat flux performance. The work in the IHHFR focused on water as a coolant and includes: (1) the development, design, and construction of the high heat flux flow loop and facility; (2) test section development, design, and fabrication; and, (3) single-side heat flux experiments to produce 2-D boiling curves and 3-D conjugate heat transfer measurements for single-side heated test sections. This work provides data for comparisons with previously developed andmore » new single-side heated correlations and approaches that address the single-side heated effect on heat transfer. In addition, this work includes the addition of single-side heated circular TS and a monoblock test section with a helical wire insert. Finally, the present work includes: (1) data base expansion for the monoblock with a helical wire insert (only for the latter geometry), (2) prediction and verification using finite element, (3) monoblock model and methodology development analyses, and (4) an alternate model development for a hypervapotron and related conjugate heat transfer controlling parameters.« less

Applications of Magnetic Suspension Technology to Large Scale Facilities: Progress, Problems and Promises

NASA Technical Reports Server (NTRS)

Britcher, Colin P.

1997-01-01

This paper will briefly review previous work in wind tunnel Magnetic Suspension and Balance Systems (MSBS) and will examine the handful of systems around the world currently known to be in operational condition or undergoing recommissioning. Technical developments emerging from research programs at NASA and elsewhere will be reviewed briefly, where there is potential impact on large-scale MSBSS. The likely aerodynamic applications for large MSBSs will be addressed, since these applications should properly drive system designs. A recently proposed application to ultra-high Reynolds number testing will then be addressed in some detail. Finally, some opinions on the technical feasibility and usefulness of a large MSBS will be given.

Updating of working memory: lingering bindings.

PubMed

Oberauer, Klaus; Vockenberg, Kerstin

2009-05-01

Three experiments investigated proactive interference and proactive facilitation in a memory-updating paradigm. Participants remembered several letters or spatial patterns, distinguished by their spatial positions, and updated them by new stimuli up to 20 times per trial. Self-paced updating times were shorter when an item previously remembered and then replaced reappeared in the same location than when it reappeared in a different location. This effect demonstrates residual memory for no-longer-relevant bindings of items to locations. The effect increased with the number of items to be remembered. With one exception, updating times did not increase, and recall of final values did not decrease, over successive updating steps, thus providing little evidence for proactive interference building up cumulatively.

An overview of data acquisition, signal coding and data analysis techniques for MST radars

NASA Technical Reports Server (NTRS)

Rastogi, P. K.

1986-01-01

An overview is given of the data acquisition, signal processing, and data analysis techniques that are currently in use with high power MST/ST (mesosphere stratosphere troposphere/stratosphere troposphere) radars. This review supplements the works of Rastogi (1983) and Farley (1984) presented at previous MAP workshops. A general description is given of data acquisition and signal processing operations and they are characterized on the basis of their disparate time scales. Then signal coding, a brief description of frequently used codes, and their limitations are discussed, and finally, several aspects of statistical data processing such as signal statistics, power spectrum and autocovariance analysis, outlier removal techniques are discussed.

2,2'-Bis(monoacylglycero) PO 4 (BMP), but Not 3,1'-BMP, Increases Membrane Curvature Stress to Enhance α-Tocopherol Transfer Protein Binding to Membranes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baptist, Matilda; Panagabko, Candace; Nickels, Jonathan D.

2015-01-21

Previous work revealed that α-tocopherol transfer protein (α-TTP) co-localizes with bis(monoacylglycero)phosphate (BMP) in late endosomes. BMP is a lipid unique to late endosomes and is believed to induce membrane curvature and support the multivesicular nature of this organelle. In this paper, we examined the effect of BMP on α-TTP binding to membranes using dual polarization interferometry and vesicle-binding assay. α-TTP binding to membranes is increased by the curvature-inducing lipid BMP. Finally, α-TTP binds to membranes with greater affinity when they contain the 2,2'-BMP versus 3,1'-BMP isomers.

Adaptive exponential synchronization of complex-valued Cohen-Grossberg neural networks with known and unknown parameters.

PubMed

Hu, Jin; Zeng, Chunna

2017-02-01

The complex-valued Cohen-Grossberg neural network is a special kind of complex-valued neural network. In this paper, the synchronization problem of a class of complex-valued Cohen-Grossberg neural networks with known and unknown parameters is investigated. By using Lyapunov functionals and the adaptive control method based on parameter identification, some adaptive feedback schemes are proposed to achieve synchronization exponentially between the drive and response systems. The results obtained in this paper have extended and improved some previous works on adaptive synchronization of Cohen-Grossberg neural networks. Finally, two numerical examples are given to demonstrate the effectiveness of the theoretical results. Copyright © 2016 Elsevier Ltd. All rights reserved.

Structural partitioning of complex structures in the medium-frequency range. An application to an automotive vehicle

NASA Astrophysics Data System (ADS)

Kassem, M.; Soize, C.; Gagliardini, L.

2011-02-01

In a recent work [ Journal of Sound and Vibration 323 (2009) 849-863] the authors presented an energy-density field approach for the vibroacoustic analysis of complex structures in the low and medium frequency ranges. In this approach, a local vibroacoustic energy model as well as a simplification of this model were constructed. In this paper, firstly an extension of the previous theory is performed in order to include the case of general input forces and secondly, a structural partitioning methodology is presented along with a set of tools used for the construction of a partitioning. Finally, an application is presented for an automotive vehicle.

Applied Meteorology Unit (AMU) Quarterly Report Fourth Quarter FY-14

NASA Technical Reports Server (NTRS)

Bauman, William H.; Crawford, Winifred C.; Watson, Leela R.; Shafer, Jaclyn

2014-01-01

Ms. Crawford completed the final report for the dual-Doppler wind field task. Dr. Bauman completed transitioning the 915-MHz and 50-MHz Doppler Radar Wind Profiler (DRWP) splicing algorithm developed at Marshall Space Flight Center (MSFC) into the AMU Upper Winds Tool. Dr. Watson completed work to assimilate data into model configurations for Wallops Flight Facility (WFF) and Kennedy Space Center/Cape Canaveral Air Force Station (KSC/CCAFS). Ms. Shafer began evaluating the a local high-resolution model she had set up previously for its ability to forecast weather elements that affect launches at KSC/CCAFS. Dr. Watson began a task to optimize the data-assimilated model she just developed to run in real time.

Linear feature extraction from radar imagery: SBIR (Small Business Innovative Research), phase 2, option 2

NASA Astrophysics Data System (ADS)

Milgram, David L.; Kahn, Philip; Conner, Gary D.; Lawton, Daryl T.

1988-12-01

The goal of this effort is to develop and demonstrate prototype processing capabilities for a knowledge-based system to automatically extract and analyze features from Synthetic Aperture Radar (SAR) imagery. This effort constitutes Phase 2 funding through the Defense Small Business Innovative Research (SBIR) Program. Previous work examined the feasibility of and technology issues involved in the development of an automated linear feature extraction system. This final report documents this examination and the technologies involved in automating this image understanding task. In particular, it reports on a major software delivery containing an image processing algorithmic base, a perceptual structures manipulation package, a preliminary hypothesis management framework and an enhanced user interface.

Four-year incidence of sick leave because of neck and shoulder pain and its association with work and lifestyle.

PubMed

Alipour, Akbar; Ghaffari, Mostafa; Shariati, Batoul; Jensen, Irene; Vingard, Eva

2009-02-15

Four-year prospective cohort study. To find the incidence of sick leave because of neck and shoulder pain (NSP) in industrial workers, and its association with work and lifestyle risk factors. Longitudinal studies to investigate NSP incidence and risk factors are rare, and even fewer have been conducted in middle- and low-income countries. After inviting all full-time employees of an Iranian car manufacturing company with 18,031 employees to participate in a baseline study, they were followed for 4 years. New episodes of sick leave because of NSP have been calculated based on sickness absence registration between the years 2003 and 2007. The incidence was compared for participants and nonparticipants. The association between sick leave, physical, and psychosocial risk factors at work, and previous self-reported NSP, was calculated for the remaining population of baseline participants (12,184 employees) during a 4-year follow-up. During a 4-year follow-up of study subjects for the remaining participants of the baseline study, the incidence of sick leave was 0.8% (98 sick leave cases in 12,184 employees). For nonparticipants this incidence was 4.2% (130 cases in 3127 employees). In the final regression model for sick leave cases, the remaining factors for potential physical risk factors were repetitive work and sitting positions at work; for psychosocial factors unattractive work was the only significant remaining factor. The incidence of NSP based on sick leave is definitely very low compared with previous studies in high-income countries. This incidence varies between participants and nonparticipants. Risk factors for sick leave differ from risk factors for self-reported pain. A young population, job security, the insurance system, different health behaviors, and healthy worker bias, are all factors that may affect the results, and sick-leave as an outcome must be interpreted with more caution in middle- and low-income countries.

Effect of interfacial structures on spin dependent tunneling in epitaxial L1 0-FePt/MgO/FePt perpendicular magnetic tunnel junctions

DOE PAGES

Yang, G.; Li, D. L.; Wang, S. G.; ...

2015-02-24

In this study, epitaxial FePt(001)/MgO/FePt magnetic tunnel junctions with L1 0-FePt electrodes showing perpendicular magnetic anisotropy were fabricated by molecular beam epitaxial growth. Tunnel magnetoresistance ratios of 21% and 53% were obtained at 300 K and 10 K, respectively. Our previous work, based on transmission electron microscopy, confirmed a semi-coherent interfacial structure with atomic steps (Kohn et al., APL 102, 062403 (2013)). Here, we show by x-ray photoemission spectroscopy and first-principles calculation that the bottom FePt/MgO interface is either Pt-terminated for regular growth or when an Fe layer is inserted at the interface, it is chemically bonded to O. Finally,more » both these structures have a dominant role in spin dependent tunneling across the MgO barrier resulting in a decrease of the tunneling magnetoresistance ratio compared with previous predictions.« less

Lower Columbia River and Estuary Ecosystem Restoration Program Reference Site Study: 2011 Restoration Analysis - FINAL REPORT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Borde, Amy B.; Cullinan, Valerie I.; Diefenderfer, Heida L.

The Reference Site (RS) study is part of the research, monitoring, and evaluation (RME) effort developed by the Action Agencies (Bonneville Power Administration [BPA], U.S. Army Corps of Engineers, Portland District [USACE], and U.S. Bureau of Reclamation) in response to Federal Columbia River Power System (FCRPS) Biological Opinions (BiOp). While the RS study was initiated in 2007, data have been collected at relatively undisturbed reference wetland sites in the LCRE by PNNL and collaborators since 2005. These data on habitat structural metrics were previously summarized to provide baseline characterization of 51 wetlands throughout the estuarine and tidal freshwater portions ofmore » the 235-km LCRE; however, further analysis of these data has been limited. Therefore, in 2011, we conducted additional analyses of existing field data previously collected for the Columbia Estuary Ecosystem Restoration Program (CEERP) - including data collected by PNNL and others - to help inform the multi-agency restoration planning and ecosystem management work underway in the LCRE.« less

Understanding and mimicking the dual optimality of the fly ear

NASA Astrophysics Data System (ADS)

Liu, Haijun; Currano, Luke; Gee, Danny; Helms, Tristan; Yu, Miao

2013-08-01

The fly Ormia ochracea has the remarkable ability, given an eardrum separation of only 520 μm, to pinpoint the 5 kHz chirp of its cricket host. Previous research showed that the two eardrums are mechanically coupled, which amplifies the directional cues. We have now performed a mechanics and optimization analysis which reveals that the right coupling strength is key: it results in simultaneously optimized directional sensitivity and directional cue linearity at 5 kHz. We next demonstrated that this dual optimality is replicable in a synthetic device and can be tailored for a desired frequency. Finally, we demonstrated a miniature sensor endowed with this dual-optimality at 8 kHz with unparalleled sound localization. This work provides a quantitative and mechanistic explanation for the fly's sound-localization ability from a new perspective, and it provides a framework for the development of fly-ear inspired sensors to overcoming a previously-insurmountable size constraint in engineered sound-localization systems.

Comparison of functional group selective ion-molecule reactions of trimethyl borate in different ion trap mass spectrometers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Habicht, S C; Vinueza, Nelson R; Amundson, Lucas M

2011-02-01

We report here a comparison of the use of diagnostic ion–molecule reactions for the identification of oxygen-containing functional groups in Fourier-transform ion cyclotron resonance (FTICR) and linear quadrupole ion trap (LQIT) mass spectrometers. The ultimate goal of this research is to be able to identify functionalities in previously unknown analytes by using many different types of mass spectrometers. Previous work has focused on the reactions of various boron reagents with protonated oxygen-containing analytes in FTICR mass spectrometers. By using a LQIT modified to allow the introduction of neutral reagents into the helium buffer gas, this methodology has been successfully implementedmore » to this type of an ion trap instrument. The products obtained from the reactions of trimethyl borate (TMB) with various protonated analytes are compared for the two instruments. Finally, the ability to integrate these reactions into LC-MS experiments on the LQIT is demonstrated.« less

A digital waveguide-based approach for Clavinet modeling and synthesis

NASA Astrophysics Data System (ADS)

Gabrielli, Leonardo; Välimäki, Vesa; Penttinen, Henri; Squartini, Stefano; Bilbao, Stefan

2013-12-01

The Clavinet is an electromechanical musical instrument produced in the mid-twentieth century. As is the case for other vintage instruments, it is subject to aging and requires great effort to be maintained or restored. This paper reports analyses conducted on a Hohner Clavinet D6 and proposes a computational model to faithfully reproduce the Clavinet sound in real time, from tone generation to the emulation of the electronic components. The string excitation signal model is physically inspired and represents a cheap solution in terms of both computational resources and especially memory requirements (compared, e.g., to sample playback systems). Pickups and amplifier models have been implemented which enhance the natural character of the sound with respect to previous work. A model has been implemented on a real-time software platform, Pure Data, capable of a 10-voice polyphony with low latency on an embedded device. Finally, subjective listening tests conducted using the current model are compared to previous tests showing slightly improved results.

Association Reactions at Low Pressure: 5. The CH(sub 3)+/HCN System. A Final Word?

NASA Technical Reports Server (NTRS)

Anicich, V.; Sen, A.; Huntress, W.; McEwan, M.

1994-01-01

The reaction of the methyl cation with hydrogen cyanide is revisited. We have confidence that we have resolved a long standing apparent contradiction of experimental results. A literature history is presented along with one new experiment and a reexamination of an old experiment. In this present work it is shown that all of the previous studies had made consistent observations. Yet, each of the previous studies failed to observe all of the information present. The methyl cation does react with HCN by radiative association, a fact which had been in doubt. The product ions formed in the two-body and three-body processes react differently with HCN. The collisionally stabilized association product formed by a three-body mechanism does not react with HCN and is readily detected in the experiments. The radiatively stabilized association product, formed by a slow two-body reaction, is not detected because it reacts with HCN by a fast proton transfer reaction forming the protonated HCN ion.

High-Performance Piezoresistive MEMS Strain Sensor with Low Thermal Sensitivity

PubMed Central

Mohammed, Ahmed A. S.; Moussa, Walied A.; Lou, Edmond

2011-01-01

This paper presents the experimental evaluation of a new piezoresistive MEMS strain sensor. Geometric characteristics of the sensor silicon carrier have been employed to improve the sensor sensitivity. Surface features or trenches have been introduced in the vicinity of the sensing elements. These features create stress concentration regions (SCRs) and as a result, the strain/stress field was altered. The improved sensing sensitivity compensated for the signal loss. The feasibility of this methodology was proved in a previous work using Finite Element Analysis (FEA). This paper provides the experimental part of the previous study. The experiments covered a temperature range from −50 °C to +50 °C. The MEMS sensors are fabricated using five different doping concentrations. FEA is also utilized to investigate the effect of material properties and layer thickness of the bonding adhesive on the sensor response. The experimental findings are compared to the simulation results to guide selection of bonding adhesive and installation procedure. Finally, FEA was used to analyze the effect of rotational/alignment errors. PMID:22319384

'I love nursing, but..'- qualitative findings from Australian aged-care nurses about their intrinsic, extrinsic and social work values.

PubMed

Tuckett, Anthony; Parker, Deborah; Eley, Robert M; Hegney, Desley

2009-12-01

Aim.  The aim of this qualitative analysis - a component of a larger survey study, was to provide insights and understandings about intrinsic and extrinsic work values for nurses in aged-care. Background.  Intrinsic and extrinsic work values impact on nurses' job satisfaction and ultimately nursing retention. This study contributes further to knowledge development in this area by building on a previous work values study in aged-care nursing. Methods.  This paper presents the qualitative research findings from the final open-ended question from a survey of nurses employed in the aged-care sector in the State of Queensland, Australia in 2007. Data from a cohort of 105 aged care sector nurses was analysed relying on deductive content analysis. Findings.  Two intrinsic work values emerged - low morale and images of nursing and two extrinsic work values emerged - remuneration and working conditions. The work value 'working conditions' comprised four aspects of aged-care work, specifically staff turnover, workplace violence, care team membership specifically the Assistants-in-Nursing and paperwork. A single social workplace value 'support by management' is discussed as identified as important to these nurses. Conclusion.  Qualitative insights into aged-care nurses' intrinsic and extrinsic work values suggest that work satisfaction is low. Workforce policy makers and employers of nurses in aged-care need to comprehend the relationship between job satisfaction, retention and work values. Relevance to clinical practice.  These findings have implications for recruitment, retention and workforce planning within the aged-care environment. © 2009 Blackwell Publishing Ltd.

77 FR 43721 - Examinations of Work Areas in Underground Coal Mines for Violations of Mandatory Health or Safety...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-26

... Examinations of Work Areas in Underground Coal Mines for Violations of Mandatory Health or Safety Standards... effectiveness of information collection requirements contained in the final rule on Examinations of Work Areas... requirements in MSHA's final rule on Examinations of Work Areas in Underground Coal Mines for Violations of...

37 CFR 211.4 - Registration of claims of protection in mask works.

Code of Federal Regulations, 2012 CFR

2012-07-01

... version of a mask work fixed in an intermediate or final form of any semiconductor chip product. However... registration per work, owners of mask works in final forms of semiconductor chip products that are produced by... chip product that includes a plurality of circuit elements that are adaptable to be personalized into a...

37 CFR 211.4 - Registration of claims of protection in mask works.

Code of Federal Regulations, 2014 CFR

2014-07-01

... version of a mask work fixed in an intermediate or final form of any semiconductor chip product. However... registration per work, owners of mask works in final forms of semiconductor chip products that are produced by... chip product that includes a plurality of circuit elements that are adaptable to be personalized into a...

37 CFR 211.4 - Registration of claims of protection in mask works.

Code of Federal Regulations, 2013 CFR

2013-07-01

... version of a mask work fixed in an intermediate or final form of any semiconductor chip product. However... registration per work, owners of mask works in final forms of semiconductor chip products that are produced by... chip product that includes a plurality of circuit elements that are adaptable to be personalized into a...

Optimizing Teleportation Cost in Distributed Quantum Circuits

NASA Astrophysics Data System (ADS)

Zomorodi-Moghadam, Mariam; Houshmand, Mahboobeh; Houshmand, Monireh

2018-03-01

The presented work provides a procedure for optimizing the communication cost of a distributed quantum circuit (DQC) in terms of the number of qubit teleportations. Because of technology limitations which do not allow large quantum computers to work as a single processing element, distributed quantum computation is an appropriate solution to overcome this difficulty. Previous studies have applied ad-hoc solutions to distribute a quantum system for special cases and applications. In this study, a general approach is proposed to optimize the number of teleportations for a DQC consisting of two spatially separated and long-distance quantum subsystems. To this end, different configurations of locations for executing gates whose qubits are in distinct subsystems are considered and for each of these configurations, the proposed algorithm is run to find the minimum number of required teleportations. Finally, the configuration which leads to the minimum number of teleportations is reported. The proposed method can be used as an automated procedure to find the configuration with the optimal communication cost for the DQC. This cost can be used as a basic measure of the communication cost for future works in the distributed quantum circuits.

Coverage and velocity dependent sticking coefficient and particle emission kinetics in the Cl2gas + Ksolid reaction

NASA Astrophysics Data System (ADS)

Hellberg, Lars; Kasemo, Bengt

Some strongly exothermic and non-adiabatic surface adsorption events, especially those where electronegative molecules adsorb on very electropositive (low work function) surfaces, are accompanied by emission of (exo)electrons, photons, excited atoms and negative ions. The reaction of halogen molecules with halogen surfaces constitute an efficient model system for such studies. We have previously reported data for the emission of negative particles and photons in the zero coverage limit for a range of velocities of Cl2 molecules impinging on cold potassium surfaces as well as the mechanism behind these emission processes. In the present work, we focus on measurements of the kinetics, i.e. the exposure/coverage dependence, of these processes for the same system. Specifically, we present data for, (i) the separated contributions from electrons and Cl- ions of the emitted negative particles, (ii) the photon emission stemming both from excited Potassium atoms and from the equivalent process causing electron emission, (iii) the change of the work function during the initial exposure and, finally, (iv) the sticking coefficient for different Cl2 velocities and exposures.

Assessing the associative deficit of older adults in long-term and short-term/working memory.

PubMed

Chen, Tina; Naveh-Benjamin, Moshe

2012-09-01

Older adults exhibit a deficit in associative long-term memory relative to younger adults. However, the literature is inconclusive regarding whether this deficit is attenuated in short-term/working memory. To elucidate the issue, three experiments assessed younger and older adults' item and interitem associative memory and the effects of several variables that might potentially contribute to the inconsistent pattern of results in previous studies. In Experiment 1, participants were tested on item and associative recognition memory with both long-term and short-term retention intervals in a single, continuous recognition paradigm. There was an associative deficit for older adults in the short-term and long-term intervals. Using only short-term intervals, Experiment 2 utilized mixed and blocked test designs to examine the effect of test event salience. Blocking the test did not attenuate the age-related associative deficit seen in the mixed test blocks. Finally, an age-related associative deficit was found in Experiment 3, under both sequential and simultaneous presentation conditions. Even while accounting for some methodological issues, the associative deficit of older adults is evident in short-term/working memory.

Empirical research on the influencing factors of the occupational stress for construction workers

NASA Astrophysics Data System (ADS)

LV, Xing; WU, Xiang; CI, Huipeng; LIU, Qing; YAO, Yongzheng

2017-04-01

Employee’s occupational stress and safety performance are highly related, which has been generally recognized by the researchers. We did this research to understand the status of the stress for construction workers, and explore the influence factors of pressure source with characteristics of construction industry. Based on the results of previous studies, we designed questionnaire to collect the influence factors on occupational stressors. The study selected workers from certain construction units at the grass-roots level as sample source. According to the results of the questionnaire, we redesigned the interview outline, and did the semi-structured interviews on workers randomly selected. Finally, we developed a scale which combined the characteristics of construction projects in China. Using SPSS software for factor analysis, reliability analysis, and descriptive statistical analysis, the results show that there are six factors affecting the workers’ occupational stress, including The Work Itself, Family-Work, Career Development, Organization Style, Interpersonal Relationship and Role Management Style. The work itself is the main sources of occupational stress. The results can be used by the construction company to provide guidance for workers to control and manage occupational stress.

Renormalization group analysis of the 2000-2002 anti-bubble in the US S&P500 index: explanation of the hierarchy of five crashes and prediction

NASA Astrophysics Data System (ADS)

Zhou, Wei-Xing; Sornette, Didier

2003-12-01

We propose a straightforward extension of our previously proposed log-periodic power-law model of the “anti-bubble” regime of the USA stock market since the summer of 2000, in terms of the renormalization group framework to model critical points. Using a previous work by Gluzman and Sornette (Phys. Rev. E 65 (2003) 036142) on the classification of the class of Weierstrass-like functions, we show that the five crashes that occurred since August 2000 can be accurately modeled by this approach, in a fully consistent way with no additional parameters. Our theory suggests an overall consistent organization of the investors forming a collective network which interact to form the pessimistic bearish “anti-bubble” regime with intermittent acceleration of the positive feedbacks of pessimistic sentiment leading to these crashes. We develop retrospective predictions, that confirm the existence of significant arbitrage opportunities for a trader using our model. Finally, we offer a prediction for the unknown future of the US S&P500 index extending over 2003 and 2004, that refines the previous prediction of Sornette and Zhou (Quant. Finance 2 (2002) 468).

Shame, internalized homophobia, identity formation, attachment style, and the connection to relationship status in gay men.

PubMed

Brown, Jac; Trevethan, Robert

2010-09-01

This study reports on a survey of 166 gay men in Sydney, Australia, that explores the links between internalized shame, internalized homophobia, and attachment style. These variables were linked to the age of coming out, family and peer acceptance of their sexuality, relationship status, and previous marriage. Findings suggest a strong relationship between shame, internalized homophobia, and anxious and avoidant attachment style. Shame was predicted by internalized homophobia and anxious and avoidant attachment style. A significant proportion of gay men reported that they were not easily accepted when they first came out. There was a significant relationship between coming out and internalized homophobia but not with shame and attachment style. Furthermore, men who had never come out to family and friends reported higher levels of internalized homophobia but not higher levels of shame and attachment style. Of particular significance was the connection between previous marriage and higher levels of shame and internalized homophobia. Finally, gay men who were not currently in a relationship reported higher levels of shame anxious and avoidant attachment style. These findings are related to therapeutic work with gay men who have previously been married and those who are concerned with their current single status.

We should ban the OPCAB approach in CABG, just as we should ban jetliners and bicycles, or maybe not!

PubMed Central

2016-01-01

Implementing a new technical process demands a complex preparation. In cardiac surgery this complex preparation is often reduced to visiting a surgeon who is familiar with a technique. The science of learning has identified that several steps are needed towards a successful implementation. The first step is the creation of a complete conceptual approach; this demands the deposit in writing of the actions and reactions of every involved party in this new approach. By definition a successful implementation starts with the creation of a group of involved individuals willing to collaborate towards a new goal. Then every teachable component, described in this concept, needs to be worked out in simulation training, from the smallest manual step to complete scenario training for complex situations. Finally, optimal organisational learning needs to have an existing database of the previous situation, a clear goal and objective and a new database where every new approach is restudied versus the previous one, using appropriate methods of corrections for variability. A complete implementation will always be more successful versus a partial one, due to the habit in partial implementation to return to the previous routines. PMID:27942400

Impact of downward-mixing ozone on surface ozone accumulation in southern Taiwan.

PubMed

Lin, Ching-Ho

2008-04-01

The ozone that initially presents in the previous day's afternoon mixing layer can remain in the nighttime atmosphere and then be carried over to the next morning. Finally, this ozone can be brought to the ground by downward mixing as mixing depth increases during the daytime, thereby increasing surface ozone concentrations. Variation of ozone concentration during each of these periods is investigated in this work. First, ozone concentrations existing in the daily early morning atmosphere at the altitude range of the daily maximum mixing depth (residual ozone concentrations) were measured using tethered ozonesondes on 52 experimental days during 2004-2005 in southern Taiwan. Daily downward-mixing ozone concentrations were calculated by a box model coupling the measured daily residual ozone concentrations and daily mixing depth variations. The ozone concentrations upwind in the previous day's afternoon mixing layer were estimated by the combination of back air trajectory analysis and known previous day's surface ozone distributions. Additionally, the relationship between daily downward-mixing ozone concentration and daily photochemically produced ozone concentration was examined. The latter was calculated by removing the former from daily surface maximum ozone concentration. The measured daily residual ozone concentrations distributed at 12-74 parts per billion (ppb) with an average of 42 +/- 17 ppb are well correlated with the previous upwind ozone concentration (R2 = 0.54-0.65). Approximately 60% of the previous upwind ozone was estimated to be carried over to the next morning and became the observed residual ozone. The daily downward-mixing ozone contributes 48 +/- 18% of the daily surface maximum ozone concentration, indicating that the downward-mixing ozone is as important as daily photochemically produced ozone to daily surface maximum ozone accumulation. The daily downward-mixing ozone is poorly correlated with the daily photochemically produced ozone and contributes significantly to the daily variation of surface maximum ozone concentrations (R2 = 0.19). However, the contribution of downward-mixing ozone to daily ozone variation is not included in most existing statistical models developed for predicting daily ozone variation. Finally, daily surface maximum ozone concentration is positively correlated with daily afternoon mixing depth, attributable to the downward-mixing ozone.

Surgical Treatment of Anal Stenosis with Diamond Flap Anoplasty Performed in a Calibrated Fashion.

PubMed

Gülen, Merter; Leventoğlu, Sezai; Ege, Bahadir; Menteş, B Bülent

2016-03-01

Regarding anoplasty for anal stenosis, it is not clear to what extent the final anal caliber should be targeted. The aim of this study was to investigate the results of diamond-flap anoplasty performed in a calibrated manner for the treatment of severe anal stenosis due to a previous hemorrhoidectomy. Prospectively prepared standard forms were evaluated retrospectively. Anoplasty with unilateral or bilateral diamond flaps was performed for moderate or severe anal stenosis, targeting a final anal caliber of 25 to 26 mm. The demographic characteristics, causes of anal stenosis, number of previous surgeries, anal stenosis staging (Milsom and Mazier), anal calibers (millimeter), the Cleveland Clinic Incontinence Score, and the modified obstructed defecation syndrome Longo score were recorded on pre-prepared standard forms, as well as postoperative complications and the time of return to work. From January 2011 to July 2013, 18 patients (12 males, 67%) with a median age of 39 years (range, 27-70) were treated. All of the patients had a history of previous hemorrhoidectomy. The number of previous corrective interventions was 2.1 ± 1.8 (range, 0-4), and 2 patients had a history of failed anoplasty. Five patients (28%) had moderate anal stenosis and 13 (72%) had severe anal stenosis. Preoperative, intraoperative, and 12-month postoperative anal calibration values were 9 ± 3 mm (range, 5-15), 25 ± 0.75 mm (range, 24-26), and 25 ± 1 mm (range, 23-27) (p < 0.0001, for immediate postoperative and 12-month postoperative anal calibers compared with the intraoperative). Preoperative and 12-month postoperative Cleveland Clinic Incontinence Scores were 0.83 ± 1.15 (range, 0-4) and 0.39 ± 0.70 (range, 0-2) (p = 1.0). The clinical success rate was 88.9%. No severe postoperative complications were observed. This study was limited because it was a single-armed, retrospective analysis of prospectively designed data. Diamond-flap anoplasty performed in a standardized and calibrated manner is a highly successful method for the treatment of anal stenosis caused by previous hemorrhoidectomy.

Tech Prep II: Implementation Final Report.

ERIC Educational Resources Information Center

Brown, Jane A.

This document contains the final progress report on a tech prep implementation project and the Work Force Challenge 2000 Report developed during the project. The final report lists these major accomplishments: approximately 1,500 educators in grades K-12 were provided information concerning future global issues in the work force and the effects in…

Global Failure Modes in Composite Structures for High Altitudes

NASA Technical Reports Server (NTRS)

Knauss, W. G.

2004-01-01

This report summarizes the accomplishments under the referenced grant. The work described was started under the guidance and supervision of the late Dr. James Stames as the technical contact. It was aimed at investigating the development of analysis tools to deal with the problem of rupture in reinforced structural skin of future composites-based aircraft. It was of particular interest to assess methods by which failure features reminiscent of cracks in metallic structures would develop and propagate in fiber reinforced structures in interaction with the reinforcing frame. To eventually achieve that goal it was necessary to first understand the stress or strain distribution at the front of such features so that interactions between such features and reinforcing agents could be assessed computationally. Thus the major emphasis here was on the assessment of damage front and methods on how to assess or characterize it. During the conduct of this research program Dr. Stames changed to a different NASA- internal assignment, which divorced him of the direct supervision of this grant. A student who was approximately % into the completion of his Ph.D. research needed to finish this work, and NASA funds were made available under Dr. Damodar Ambur, the successor Branch Manager for Dr. James Starnes, for the completion of this work. The current grant was the thus a new and fmal support increment for completion of the started research. Final reports for previous funding have been completed and submitted. Because of the interconnection of this last phase of the investigation with previous work it is deemed useful to make the Ph.D. thesis by Luis Gonzales the body of this report.

Seasonal Influenza Forecasting in Real Time Using the Incidence Decay With Exponential Adjustment Model.

PubMed

Nasserie, Tahmina; Tuite, Ashleigh R; Whitmore, Lindsay; Hatchette, Todd; Drews, Steven J; Peci, Adriana; Kwong, Jeffrey C; Friedman, Dara; Garber, Gary; Gubbay, Jonathan; Fisman, David N

2017-01-01

Seasonal influenza epidemics occur frequently. Rapid characterization of seasonal dynamics and forecasting of epidemic peaks and final sizes could help support real-time decision-making related to vaccination and other control measures. Real-time forecasting remains challenging. We used the previously described "incidence decay with exponential adjustment" (IDEA) model, a 2-parameter phenomenological model, to evaluate the characteristics of the 2015-2016 influenza season in 4 Canadian jurisdictions: the Provinces of Alberta, Nova Scotia and Ontario, and the City of Ottawa. Model fits were updated weekly with receipt of incident virologically confirmed case counts. Best-fit models were used to project seasonal influenza peaks and epidemic final sizes. The 2015-2016 influenza season was mild and late-peaking. Parameter estimates generated through fitting were consistent in the 2 largest jurisdictions (Ontario and Alberta) and with pooled data including Nova Scotia counts (R 0 approximately 1.4 for all fits). Lower R 0 estimates were generated in Nova Scotia and Ottawa. Final size projections that made use of complete time series were accurate to within 6% of true final sizes, but final size was using pre-peak data. Projections of epidemic peaks stabilized before the true epidemic peak, but these were persistently early (~2 weeks) relative to the true peak. A simple, 2-parameter influenza model provided reasonably accurate real-time projections of influenza seasonal dynamics in an atypically late, mild influenza season. Challenges are similar to those seen with more complex forecasting methodologies. Future work includes identification of seasonal characteristics associated with variability in model performance.

FINAL REPORT INTEGRATED DM1200 MELTER TESTING USING AZ 102 AND C 106/AY-102 HLW SIMULANTS: HLW SIMULANT VERIFICATION VSL-05R5800-1 REV 0 6/27/05

DOE Office of Scientific and Technical Information (OSTI.GOV)

KRUGER AA; MATLACK KS; GONG W

2011-12-29

The principal objectives of the DM1200 melter tests were to determine the effects of feed rheology, feed solid content, and bubbler configuration on glass production rate and off-gas system performance while processing the HLW AZ-101 and C-106/AY-102 feed compositions; characterize melter off-gas emissions; characterize the performance of the prototypical off-gas system components, as well as their integrated performance; characterize the feed, glass product, and off-gas effluents; and perform pre- and post test inspections of system components. The specific objectives (including test success criteria) of this testing, along with how each objective was met, are outlined in a table. The datamore » provided in this Final Report address the impacts of HLW melter feed rheology on melter throughput and validation of the simulated HLW melter feeds. The primary purpose of this testing is to further validate/verify the HLW melter simulants that have been used for previous melter testing and to support their continued use in developing melter and off-gas related processing information for the Project. The primary simulant property in question is rheology. Simulants and melter feeds used in all previous melter tests were produced by direct addition of chemicals; these feed tend to be less viscous than rheological the upper-bound feeds made from actual wastes. Data provided here compare melter processing for the melter feed used in all previous DM100 and DM1200 tests (nominal melter feed) with feed adjusted by the feed vendor (NOAH Technologies) to be more viscous, thereby simulating more closely the upperbounding feed produced from actual waste. This report provides results of tests that are described in the Test Plan for this work. The Test Plan is responsive to one of several test objectives covered in the WTP Test Specification for this work; consequently, only part of the scope described in the Test Specification was addressed in this particular Test Plan. For the purpose of comparison, the tests reported here were performed with AZ-102 and C-106/AY-102 HLW simulants and glass compositions that are essentially the same as those used for recent DM1200 tests. One exception was the use of an alternate, higher-waste-loading C-106/AY-102 glass composition that was used in previous DM100 tests to further evaluate the performance of the optimized bubbler configuration.« less

Synthesis and Evaluation of the Tumor Cell Growth Inhibitory Potential of New Putative HSP90 Inhibitors.

PubMed

Bizarro, Ana; Sousa, Diana; Lima, Raquel T; Musso, Loana; Cincinelli, Raffaella; Zuco, Vantina; De Cesare, Michelandrea; Dallavalle, Sabrina; Vasconcelos, M Helena

2018-02-13

Heat shock protein 90 (HSP90) is a well-known target for cancer therapy. In a previous work, some of us have reported a series of 3-aryl-naphtho[2,3- d ]isoxazole-4,9-diones as inhibitors of HSP90. In the present work, various compounds with new chromenopyridinone and thiochromenopyridinone scaffolds were synthesized as potential HSP90 inhibitors. Their binding affinity to HSP90 was studied in vitro. Selected compounds ( 5 and 8 ) were further studied in various tumor cell lines regarding their potential to cause cell growth inhibition, alter the cell cycle profile, inhibit proliferation, and induce apoptosis. Their effect on HSP90 client protein levels was also confirmed in two cell lines. Finally, the antitumor activity of compound 8 was studied in A431 squamous cell carcinoma xenografts in nude mice. Our results indicated that treatment with compounds 5 and 8 decreased the proliferation of tumor cell lines and compound 8 induced apoptosis. In addition, these two compounds were able to downregulate selected proteins known as "clients" of HSP90. Finally, treatment of xenografted mice with compound 5 resulted in a considerable dose-dependent inhibition of tumor growth. Our results show that two new compounds with a chromenopyridinone and thiochromenopyridinone scaffold are promising putative HSP90 inhibitors causing tumor cell growth inhibition.

Deciphering and engineering of the final step halogenase for improved chlortetracycline biosynthesis in industrial Streptomyces aureofaciens.

PubMed

Zhu, Tao; Cheng, Xueqing; Liu, Yuntian; Deng, Zixin; You, Delin

2013-09-01

Chlortetracycline (CTC) is an important member from antibiotics tetracycline (TC) family, which inhibits protein synthesis in bacteria and is widely involved in clinical therapy, animal feeds and aquaculture. Previous works have reported intricately the biosynthesis of CTC from the intermediates in random mutants of Streptomyces aureofaciens and the crucial chlorination remained unclear. We have developed the genetic manipulation in an industrial producer, in which about 15.0g/l CTC predominated along with 1.2g/l TC, and discovered that chlorination by ctcP (an FADH2-dependent halogenase gene) is the last inefficient step during CTC biosynthesis. Firstly, the ΔctcP strain accumulated about 18.9g/l "clean" TC without KBr addition and abolished the production of CTC. Subsequently, CtcP was identified to exhibit a substrate stereo-specificity to absolute TC (4S) rather than TC (4R), with low kcat of 0.51±0.01min(-1), while it could halogenate several TC analogs. Accordingly, we devised a strategy for overexpression of ctcP in S. aureofaciens and improved CTC production to a final titer of 25.9g/l. We anticipate that our work will provide a biotechnological potential of enzymatic evolution and strain engineering towards new TC derivatives in microorganisms. © 2013 The Authors. Published by Elsevier Inc. All rights reserved.

Beta oscillations reflect supramodal information during perceptual judgment.

PubMed

Haegens, Saskia; Vergara, José; Rossi-Pool, Román; Lemus, Luis; Romo, Ranulfo

2017-12-26

Previous work on perceptual decision making in the sensorimotor system has shown population dynamics in the beta band, corresponding to the encoding of stimulus properties and the final decision outcome. Here, we asked how oscillatory dynamics in the medial premotor cortex (MPC) contribute to supramodal perceptual decision making. We recorded local field potentials (LFPs) and spikes in two monkeys trained to perform a tactile-acoustic frequency discrimination task, including both unimodal and crossmodal conditions. We studied the role of oscillatory activity as a function of stimulus properties (frequency and sensory modality), as well as decision outcome. We found that beta-band power correlated with relevant stimulus properties: there was a significant modulation by stimulus frequency during the working-memory (WM) retention interval, as well as modulation by stimulus modality-the latter was observed only in the case of a purely unimodal task, where modality information was relevant to prepare for the upcoming second stimulus. Furthermore, we found a significant modulation of beta power during the comparison and decision period, which was predictive of decision outcome. Finally, beta-band spike-field coherence (SFC) matched these LFP observations. In conclusion, we demonstrate that beta power in MPC is reflective of stimulus features in a supramodal, context-dependent manner, and additionally reflects the decision outcome. We propose that these beta modulations are a signature of the recruitment of functional neuronal ensembles, which encode task-relevant information.

Herbert Easterly auxiliary truck heater. Final technical report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

The objective of this work was to continue the development of the Herbert Easterly heater apparatus for vehicles, such as semi-trailer tractors in order to fully establish its technical feasibility and provide the basis for its commercialization. This heater is auxiliary to the vehicle`s primary heating system. With the engine off it heats both the vehicle engine to a temperature at which it starts easily and the vehicle passenger compartment. Specifically, this heater is automatically ignitable, operates directly from the vehicle diesel fuel supply and preheats the vehicle engine fuel prior to combustion. During the course of this work ninemore » different versions of prototype heaters were designed, constructed and tested. All designs were based on the ideas and principles outlined in the Easterly patent. Each successive version incorporated design and fabrication improvements relative to the previous version. The final version, Prototype 9, utilized a multiple water jacket design to capture additional heat from the combustion gases prior to exhausting to the atmosphere. This final prototype exceeded the performance of a commercially available Webasto DBW-2010 using the same commercial burner as the one used in the Webasto unit. The time required to raise the heater fluid temperature by 120{degree}F was 23% less (20 minutes compared to 26 minutes) for Prototype 9 compared to the commercially available unit. In addition a prototype heat exchanger for preheating engine fuel was designed, fabricated and tested. It was also determined that the Prototype 9 auxiliary heater could operate at 85{degree}F for approximately 6 hours on a fully charged 12 volt marine battery rated to deliver 500 cold cranking amps.« less

Prognostic model of survival for typical bronchial carcinoid tumours: analysis of 1109 patients on behalf of the European Association of Thoracic Surgeons (ESTS) Neuroendocrine Tumours Working Group.

PubMed

Filosso, Pier Luigi; Guerrera, Francesco; Evangelista, Andrea; Welter, Stefan; Thomas, Pascal; Casado, Paula Moreno; Rendina, Erino Angelo; Venuta, Federico; Ampollini, Luca; Brunelli, Alessandro; Stella, Franco; Nosotti, Mario; Raveglia, Federico; Larocca, Valentina; Rena, Ottavio; Margaritora, Stefano; Ardissone, Francesco; Travis, William D; Sarkaria, Inderpal; Sagan, Dariusz

2015-09-01

Typical carcinoids (TCs) are uncommon, slow-growing neoplasms, usually with high 5-year survival rates. As these are rare tumours, their management is still based on small clinical observations and no international guidelines exist. Based on the European Society of Thoracic Surgeon Neuroendocrine Tumours Working Group (NET-WG) Database, we evaluated factors that may influence TCs mortality. Using the NET-WG database, an analysis on TC survival was performed. Overall survival (OS) was calculated starting from the date of intervention. Predictors of OS were investigated using the Cox model with shared frailty (accounting for the within-centre correlation). Candidate predictors were: gender, age, smoking habit, tumour location, previous malignancy, Eastern Cooperative Oncology Group (ECOG) performance status (PS), pT, pN, TNM stage and tumour vascular invasion. The final model included predictors with P ≤ 0.15 after a backward selection. Missing data in the evaluated predictors were multiple-imputed and combined estimates were obtained from five imputed data sets. For 58 of 1167 TC patients vital status was unavailable and analyses were therefore performed on 1109 patients from 17 institutions worldwide. During a median follow-up of 50 months, 87 patients died, with a 5-year OS rate of 93.7% (95% confidence interval: 91.7-95.3). Backward selection resulted in a prediction model for mortality containing age, gender, previous malignancies, peripheral tumour, TNM stage and ECOG PS. The final model showed a good discrimination ability with a C-statistic equal to 0.836 (bootstrap optimism-corrected 0.806). We presented and validated a promising prognostic model for TC survival, showing good calibration and discrimination ability. Further analyses are needed and could be focused on an external validation of this model. © The Author 2015. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

Retrieval Practice Fails to Insulate Episodic Memories against Interference after Stroke.

PubMed

Pastötter, Bernhard; Eberle, Hanna; Aue, Ingo; Bäuml, Karl-Heinz T

2017-01-01

Recent work in cognitive psychology showed that retrieval practice of previously studied information can insulate this information against retroactive interference from subsequently studied other information in healthy individuals. The present study examined whether this beneficial effect of interference reduction is also present in patients with stroke. Twenty-two patients with stroke, 4.6 months post injury on average, and 22 healthy controls participated in the experiment. In each of two experimental sessions, participants first studied a list of items (list 1) and then underwent a practice phase in which the list 1 items were either restudied or retrieval practiced. Participants then either studied a second list of items (list 2) or fulfilled an unrelated distractor task. Recall of the two lists' items was assessed in a final criterion test. Results showed that, in healthy controls, additional study of list 2 items impaired final recall of list 1 items in the restudy condition but not in the retrieval practice condition. In contrast, in patients with stroke, list 2 learning impaired final list 1 recall in both conditions. The results indicate that retrieval practice insulated the tested information against retroactive interference in healthy controls, but failed to do so in patients with stroke. Possible implications of the findings for the understanding of long-term memory impairment after stroke are discussed.

Final Report of the Advanced Coal Technology Work Group

EPA Pesticide Factsheets

The Advanced Coal Technology workgroup reported to the Clean Air Act Advisory Committee. This page includes the final report of the Advanced Coal Technology Work Group to the Clean Air Act Advisory Committee.

78 FR 70949 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-27

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Final Effect of Designation of a Class of Employees for...). ACTION: Notice. SUMMARY: HHS gives notice concerning the final effect of the HHS decision to designate a..., 1967, for a number of work days aggregating at least 250 work days, occurring either solely under this...

77 FR 60437 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-03

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Final Effect of Designation of a Class of Employees for...). ACTION: Notice. SUMMARY: HHS gives notice concerning the final effect of the HHS decision to designate a... August 1, 1949, through December 31, 1967, for a number of work days aggregating at least 250 work days...

Extending and implementing the Persistent ID pillars

NASA Astrophysics Data System (ADS)

Car, Nicholas; Golodoniuc, Pavel; Klump, Jens

2017-04-01

The recent double decade anniversary of scholarly persistent identifier use has triggered journal special editions such as "20 Years of Persistent Identifiers". For such a publication, it is apt to consider the longevity of some persistent identifier (PID) mechanisms (Digital Object Identifiers) and the partial disappearance of others (Life Sciences IDs). We have previously postulated a set of "PID Pillars" [1] which are design principles aimed at ensuring PIDs can survive technology and social change and thus persist for the long term that we have drawn from our observations of PIDs at work over many years. The principles: describe how to ensure identifiers' system and organisation independence; codify the delivery of essential PID system functions; mandate a separation of PID functions from data delivery mechanisms; and require generation of policies detailing how change is handled. In this presentation, first we extend on our previous work of introducing the pillars by refining their descriptions, giving specific suggestions for each and presenting some work that addresses them. Second, we propose a baseline data model for persistent identifiers that, if used, would assist the separation of PID metadata and PID system functioning. This would allow PID system function specifics to change over time (e.g. resolver services or even resolution protocols) and yet preserve the PIDs themselves. Third, we detail our existing PID system — the PID Service [2] — that partially implements the pillars and describe both its successes and shortcomings. Finally, we describe our planned next-generation system that will aim to use the baseline data model and fully implement the pillars.

Compensatory Mitigation Rule Q&A

EPA Pesticide Factsheets

What is compensatory mitigation? How is compensatory mitigation accomplished? What does this final rule do? What are the most significant changes required by this rule compared to previous mitigation practices? What are the goals of the final rule?

Crewbot Suspension Design

NASA Technical Reports Server (NTRS)

Wood, Nathan A.

2005-01-01

Planetary Surface Robot Work Crews (RWC) represent a new class of construction robots for future deployment in planetary exploration. Rovers currently being used for the RWC platform lack the load carrying capabilities required in regular work. Two new rovers, dubbed CrewBots, being designed in JPL's Planetary Robotics Lab specifically for RWC applications greatly increase the load carrying capabilities of the platform. A major component of the rover design was the design of the rocker type suspension, which increases rover mobility. The design of the suspension for the Crewbots departed from the design of recent rovers. While many previous rovers have used internal bevel gear differentials, the increased load requirements of the Crewbots calls for a more robust system. The solution presented is the use of an external modified three-bar, slider-linkage, rocker-style suspension that increases the moment arm of the differential. The final product is a suspension system capable of supporting the extreme loading cases the RWC platform presents, without consuming a large portion of the Crewbots' internal space.

Hybrid reduced order modeling for assembly calculations

DOE PAGES

Bang, Youngsuk; Abdel-Khalik, Hany S.; Jessee, Matthew A.; ...

2015-08-14

While the accuracy of assembly calculations has greatly improved due to the increase in computer power enabling more refined description of the phase space and use of more sophisticated numerical algorithms, the computational cost continues to increase which limits the full utilization of their effectiveness for routine engineering analysis. Reduced order modeling is a mathematical vehicle that scales down the dimensionality of large-scale numerical problems to enable their repeated executions on small computing environment, often available to end users. This is done by capturing the most dominant underlying relationships between the model's inputs and outputs. Previous works demonstrated the usemore » of the reduced order modeling for a single physics code, such as a radiation transport calculation. This paper extends those works to coupled code systems as currently employed in assembly calculations. Finally, numerical tests are conducted using realistic SCALE assembly models with resonance self-shielding, neutron transport, and nuclides transmutation/depletion models representing the components of the coupled code system.« less

Hand skin reconstruction from skeletal landmarks.

PubMed

Lefèvre, P; Van Sint Jan, S; Beauthier, J P; Rooze, M

2007-11-01

Many studies related to three-dimensional facial reconstruction have been previously reported. On the other hand, no extensive work has been found in the literature about hand reconstruction as an identification method. In this paper, the feasibility of virtual reconstruction of hand skin based on (1) its skeleton and (2) another hand skin and skeleton used as template was assessed. One cadaver hand and one volunteer's hand have been used. For the two hands, computer models of the bones and skin were obtained from computerized tomography. A customized software allowed locating spatial coordinates of bony anatomical landmarks on the models. From these landmarks, the spatial relationships between the models were determined and used to interpolate the missing hand skin. The volume of the interpolated skin was compared to the real skin obtained from medical imaging for validation. Results seem to indicate that such a method is of interest to give forensic investigators morphological clues related to an individual hand skin based on its skeleton. Further work is in progress to finalize the method.

Hypercube matrix computation task

NASA Technical Reports Server (NTRS)

Calalo, Ruel H.; Imbriale, William A.; Jacobi, Nathan; Liewer, Paulett C.; Lockhart, Thomas G.; Lyzenga, Gregory A.; Lyons, James R.; Manshadi, Farzin; Patterson, Jean E.

1988-01-01

A major objective of the Hypercube Matrix Computation effort at the Jet Propulsion Laboratory (JPL) is to investigate the applicability of a parallel computing architecture to the solution of large-scale electromagnetic scattering problems. Three scattering analysis codes are being implemented and assessed on a JPL/California Institute of Technology (Caltech) Mark 3 Hypercube. The codes, which utilize different underlying algorithms, give a means of evaluating the general applicability of this parallel architecture. The three analysis codes being implemented are a frequency domain method of moments code, a time domain finite difference code, and a frequency domain finite elements code. These analysis capabilities are being integrated into an electromagnetics interactive analysis workstation which can serve as a design tool for the construction of antennas and other radiating or scattering structures. The first two years of work on the Hypercube Matrix Computation effort is summarized. It includes both new developments and results as well as work previously reported in the Hypercube Matrix Computation Task: Final Report for 1986 to 1987 (JPL Publication 87-18).

Technology Development, Evaluation, and Application (TDEA) FY 1998 Progress Report Environment, Safety, and Health (ESH) Division

DOE Office of Scientific and Technical Information (OSTI.GOV)

Larry G. Hoffman; Kenneth Alvar; Thomas Buhl

1999-06-01

This progress report presents the results of 10 projects funded ($504K) in FY98 by the Technology Development, Evaluation, and Application (TDEA) Committee of the Environment, Safety, and Health Division. Nine projects are new for this year; two projects were completed in their third and final TDEA-funded year. As a result of their TDEA-funded projects, investigators have published 19 papers in professional journals, proceedings, or Los Alamos reports and presented their work at professional meetings. Supplemental funds and in-kind contributions, such as staff time, instrument use, and work space were also provided to the TDEA-funded projects by organizations external to ESHmore » Division. Products generated from the projects funded in FY98 included a new extremity dosimeter that replaced the previously used finger-ring dosimeters, a light and easy-to-use detector to measure energy deposited by neutron interactions, and a device that will allow workers to determine the severity of a hazard.« less

[Health situation assessment by primary care workers based on geographic information systems].

PubMed

Ritter, Fernando; Rosa, Roger dos Santos; Flores, Rui

2013-12-01

Primary healthcare has made little use of information systems to assess the population's health situation due to the difficulty in understanding the reports. Generic definitions of actions are common, based on empirical observations. The current study aimed to evaluate whether the introduction of georeferenced indicators can serve to better identify individuals' health situation, which would help planning actions by health teams. Healthcare workers from eight teams answered a questionnaire at three different moments: the first, before reading the information system's reports; the second after reading; and the third after using georeferencing. The results showed a significant difference in the classification of the health situation using georeferencing when compared to the previous moments (p < 0.05). Georeferencing facilitated analysis of the health situation, fostering better monitoring of work processes. Finally, use of the data points to rationalization of actions and possible upgrading of healthcare. The study suggests the use of georeferencing in the work agenda to become an effective tool for orienting actions.

Ignition and combustion characteristics of metallized propellants

NASA Technical Reports Server (NTRS)

Mueller, D. C.; Turns, Stephen R.

1991-01-01

Over the past six months, experimental investigations were continued and theoretical work on the secondary atomization process was begun. Final shakedown of the sizing/velocity measuring system was completed and the aluminum combustion detection system was modified and tested. Atomizer operation was improved to allow steady state operation over long periods of time for several slurries. To validate the theoretical modeling, work involving carbon slurry atomization and combustion was begun and qualitative observations were made. Simultaneous measurements of aluminum slurry droplet size distributions and detection of burning aluminum particles were performed at several axial locations above the burner. The principle theoretical effort was the application of a rigid shell formation model to aluminum slurries and an investigation of the effects of various parameters on the shell formation process. This shell formation model was extended to include the process leading up to droplet disruption, and previously developed analytical models were applied to yield theoretical aluminum agglomerate ignition and combustion times. The several theoretical times were compared with the experimental results.

Regulatory Supervision of Radiological Protection in the Russian Federation as Applied to Facility Decommissioning and Site Remediation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sneve, M.K.; Shandala, N.K.

2007-07-01

The Russian Federation is carrying out major work to manage the legacy of exploitation of nuclear power and use of radioactive materials. This paper describes work on-going to provide enhanced regulatory supervision of these activities as regards radiological protection. The scope includes worker and public protection in routine operation; emergency preparedness and response; radioactive waste management, including treatment, interim storage and transport as well as final disposal; and long term site restoration. Examples examined include waste from facilities in NW Russia, including remediation of previous shore technical bases (STBs) for submarines, spent fuel and radioactive waste management from ice-breakers, andmore » decommissioning of Radio-Thermal-Generators (RTGs) used in navigational devices. Consideration is given to the identification of regulatory responsibilities among different regulators; development of necessary regulatory instruments; and development of regulatory procedures for safety case reviews and compliance monitoring and international cooperation between different regulators. (authors)« less

Design and Implementation of Practical Bidirectional Texture Function Measurement Devices Focusing on the Developments at the University of Bonn

PubMed Central

Schwartz, Christopher; Sarlette, Ralf; Weinmann, Michael; Rump, Martin; Klein, Reinhard

2014-01-01

Understanding as well as realistic reproduction of the appearance of materials play an important role in computer graphics, computer vision and industry. They enable applications such as digital material design, virtual prototyping and faithful virtual surrogates for entertainment, marketing, education or cultural heritage documentation. A particularly fruitful way to obtain the digital appearance is the acquisition of reflectance from real-world material samples. Therefore, a great variety of devices to perform this task has been proposed. In this work, we investigate their practical usefulness. We first idey a set of necessary attributes and establish a general categorization of different designs that have been realized. Subsequently, we provide an in-depth discussion of three particular implementations by our work group, demonstrating advantages and disadvantages of different system designs with respect to the previously established attributes. Finally, we survey the existing literature to compare our implementation with related approaches. PMID:24787638

Repeated MDMA ("Ecstasy") exposure in adolescent male rats alters temperature regulation, spontaneous motor activity, attention, and serotonin transporter binding.

PubMed

Piper, Brian J; Fraiman, Joseph B; Meyer, Jerrold S

2005-09-01

Previous research in our laboratory found that repeated exposure of adolescent rats to 3,4-methylenedioxymethamphetamine (MDMA) impaired working memory and reduced anxiety. The present experiment extended these findings by investigating the physiological, behavioral, and neurotoxic effects of a modified MDMA treatment regimen. Male Sprague-Dawley rats received 5 mg/kg of MDMA hourly for a period of 4 hr on every fifth day from postnatal day 35-60. Acute effects of the MDMA treatment included hypothermia, serotonin syndrome behavior, and ejaculation. Body weight gain was attenuated by repeated drug administration. The animals completed anxiety and working memory tests beginning 4 days after the final MDMA dose. MDMA altered habituation to the open-field, increased locomotor activity in the elevated plus-maze, decreased attention in the novel object-recognition test, and reduced serotonin transporter binding in the neocortex. These results indicate that repeated exposure to a relatively moderate MDMA dose during adolescence produces later changes in behavior and neurochemistry. Copyright 2005 Wiley Periodicals, Inc

Schwinger-Keldysh superspace in quantum mechanics

NASA Astrophysics Data System (ADS)

Geracie, Michael; Haehl, Felix M.; Loganayagam, R.; Narayan, Prithvi; Ramirez, David M.; Rangamani, Mukund

2018-05-01

We examine, in a quantum mechanical setting, the Hilbert space representation of the Becchi, Rouet, Stora, and Tyutin (BRST) symmetry associated with Schwinger-Keldysh path integrals. This structure had been postulated to encode important constraints on influence functionals in coarse-grained systems with dissipation, or in open quantum systems. Operationally, this entails uplifting the standard Schwinger-Keldysh two-copy formalism into superspace by appending BRST ghost degrees of freedom. These statements were previously argued at the level of the correlation functions. We provide herein a complementary perspective by working out the Hilbert space structure explicitly. Our analysis clarifies two crucial issues not evident in earlier works: first, certain background ghost insertions necessary to reproduce the correct Schwinger-Keldysh correlators arise naturally, and, second, the Schwinger-Keldysh difference operators are systematically dressed by the ghost bilinears, which turn out to be necessary to give rise to a consistent operator algebra. We also elaborate on the structure of the final state (which is BRST closed) and the future boundary condition of the ghost fields.

Mechanical model development of rolling bearing-rotor systems: A review

NASA Astrophysics Data System (ADS)

Cao, Hongrui; Niu, Linkai; Xi, Songtao; Chen, Xuefeng

2018-03-01

The rolling bearing rotor (RBR) system is the kernel of many rotating machines, which affects the performance of the whole machine. Over the past decades, extensive research work has been carried out to investigate the dynamic behavior of RBR systems. However, to the best of the authors' knowledge, no comprehensive review on RBR modelling has been reported yet. To address this gap in the literature, this paper reviews and critically discusses the current progress of mechanical model development of RBR systems, and identifies future trends for research. Firstly, five kinds of rolling bearing models, i.e., the lumped-parameter model, the quasi-static model, the quasi-dynamic model, the dynamic model, and the finite element (FE) model are summarized. Then, the coupled modelling between bearing models and various rotor models including De Laval/Jeffcott rotor, rigid rotor, transfer matrix method (TMM) models and FE models are presented. Finally, the paper discusses the key challenges of previous works and provides new insights into understanding of RBR systems for their advanced future engineering applications.

Response functions of Fuji imaging plates to monoenergetic protons in the energy range 0.6-3.2 MeV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bonnet, T.; Denis-Petit, D.; Gobet, F.

2013-01-15

We have measured the responses of Fuji MS, SR, and TR imaging plates (IPs) to protons with energies ranging from 0.6 to 3.2 MeV. Monoenergetic protons were produced with the 3.5 MV AIFIRA (Applications Interdisciplinaires de Faisceaux d'Ions en Region Aquitaine) accelerator at the Centre d'Etudes Nucleaires de Bordeaux Gradignan (CENBG). The IPs were irradiated with protons backscattered off a tantalum target. We present the photo-stimulated luminescence response of the IPs together with the fading measurements for these IPs. A method is applied to allow correction of fading effects for variable proton irradiation duration. Using the IP fading corrections, amore » model of the IP response function to protons was developed. The model enables extrapolation of the IP response to protons up to proton energies of 10 MeV. Our work is finally compared to previous works conducted on Fuji TR IP response to protons.« less

A splitting algorithm for a novel regularization of Perona-Malik and application to image restoration

NASA Astrophysics Data System (ADS)

Karami, Fahd; Ziad, Lamia; Sadik, Khadija

2017-12-01

In this paper, we focus on a numerical method of a problem called the Perona-Malik inequality which we use for image denoising. This model is obtained as the limit of the Perona-Malik model and the p-Laplacian operator with p→ ∞. In Atlas et al., (Nonlinear Anal. Real World Appl 18:57-68, 2014), the authors have proved the existence and uniqueness of the solution of the proposed model. However, in their work, they used the explicit numerical scheme for approximated problem which is strongly dependent to the parameter p. To overcome this, we use in this work an efficient algorithm which is a combination of the classical additive operator splitting and a nonlinear relaxation algorithm. At last, we have presented the experimental results in image filtering show, which demonstrate the efficiency and effectiveness of our algorithm and finally, we have compared it with the previous scheme presented in Atlas et al., (Nonlinear Anal. Real World Appl 18:57-68, 2014).

Mechanical Structural Design of a MEMS-Based Piezoresistive Accelerometer for Head Injuries Monitoring: A Computational Analysis by Increments of the Sensor Mass Moment of Inertia †

PubMed Central

Messina, Marco; Njuguna, James; Palas, Chrysovalantis

2018-01-01

This work focuses on the proof-mass mechanical structural design improvement of a tri-axial piezoresistive accelerometer specifically designed for head injuries monitoring where medium-G impacts are common; for example, in sports such as racing cars or American Football. The device requires the highest sensitivity achievable with a single proof-mass approach, and a very low error (<1%) as the accuracy for these types of applications is paramount. The optimization method differs from previous work as it is based on the progressive increment of the sensor proof-mass mass moment of inertia (MMI) in all three axes. Three different designs are presented in this study, where at each step of design evolution, the MMI of the sensor proof-mass gradually increases in all axes. The work numerically demonstrates that an increment of MMI determines an increment of device sensitivity with a simultaneous reduction of cross-axis sensitivity in the particular axis under study. This is due to the linkage between the external applied stress and the distribution of mass (of the proof-mass), and therefore of its mass moment of inertia. Progressively concentrating the mass on the axes where the piezoresistors are located (i.e., x- and y-axis) by increasing the MMI in the x- and y-axis, will undoubtedly increase the longitudinal stresses applied in that areas for a given external acceleration, therefore increasing the piezoresistors fractional resistance change and eventually positively affecting the sensor sensitivity. The final device shows a sensitivity increase of about 80% in the z-axis and a reduction of cross-axis sensitivity of 18% respect to state-of-art sensors available in the literature from a previous work of the authors. Sensor design, modelling, and optimization are presented, concluding the work with results, discussion, and conclusion. PMID:29351221

Meaning of work and the returning process after breast cancer: a longitudinal study of 56 women.

PubMed

Lilliehorn, Sara; Hamberg, Katarina; Kero, Anneli; Salander, Pär

2013-06-01

An increasing number of women survive breast cancer and a majority return to work. However, findings based on mean values may conceal individual processes that need to be better understood to discuss meaningful rehabilitation. The purpose of this study is to describe the sick-leave pattern of a group of Swedish women with primary breast cancer but foremost to explore their ideas about what motivates and discourages their return to work. Fifty-six women were repeatedly interviewed over a period of 18-24 months. Interview sections that clearly illustrated the women's experiences and ideas about work were categorized using the comparative similarities-differences technique. The average length of sick leave was 410 days (range 0-942). Six months after the first day of sick leave, 29% worked at least their previous service grade. At 12 months, 55% and at 18 months 57% did so. Those treated with chemotherapy had in average more than twice as large sick leave as those who did not. Three categories emerged. 'Motives for not returning to work' consists of four subcategories: 'I'm still too fragile to return to work'; 'My workplace is a discouraging place'; 'I took an opportunity to pause' and 'I've lost the taste for work'. 'Motives for returning' consists of two sub-categories: 'Work generates and structures my everyday life' and 'I miss my workplace'. Finally, 'Transition in work approach' reflects a changed approach to work. The meaning of work varies over time, but first and foremost work was regarded as an important part of the healing process as it restores the disruption of everyday life. Guidelines cannot be reduced to a linear relationship with biomedical variables but the individual context of everyday life must be considered. © 2012 Nordic College of Caring Science.

County of Hawaii Department of Public Works: Consent Agreement and Final Order (2005)

EPA Pesticide Factsheets

Consent Agreement and Final Order for The County of Hawaii Department of Public Works, Hilo, Hawaii, including proposed order of compliance, closure of large capacity cesspools. Docket no. UIC-AO-2005-0013

Towards a theory of intention: An application of quantum mechanics within psychotherapy

NASA Astrophysics Data System (ADS)

Van Wyck, Jennifer

This study incorporated grounded research methodology to analyze and code three fields of research: psychoneuroimmunology, psychokinesis, and guided imagery. The works of Tiller (2001, 2007) and Dyer (2004) were used as a validity check for the grounded theory results and provided further input into a final theory of intention. It was found that intention requires three elements to be most successful in producing targeted outcomes. These include consciousness, thought, and emotion. The emotional aspect of intention had previously been mentioned but never incorporated into earlier theories of intention and appears to be a new finding that has potentially strong implications. The paper concludes with a discussion of how the theory of intention can inform practice in the field of psychotherapy.

Influence of the Cutting Conditions in the Surface Finishing of Turned Pieces of Titanium Alloys

NASA Astrophysics Data System (ADS)

Huerta, M.; Arroyo, P.; Sánchez Carrilero, M.; Álvarez, M.; Salguero, J.; Marcos, M.

2009-11-01

Titanium is a material that, despite its high cost, is increasingly being introduced in the aerospace industry due to both, its weight, its mechanical properties and its corrosion potential, very close to that of carbon fiber based composite material. This fact allows using Ti to form Fiber Metal Laminates Machining operations are usually used in the manufacturing processes of Ti based aerospace structural elements. These elements must be machined under high surface finish requirements. Previous works have shown the relationship between the surface roughness and the tool changes in the first instants of turning processes. From these results, new tests have been performed in an aeronautical factory, in order to analyse roughness in final pieces.

Auction-based bandwidth allocation in the Internet

NASA Astrophysics Data System (ADS)

Wei, Jiaolong; Zhang, Chi

2002-07-01

It has been widely accepted that auctioning which is the pricing approach with minimal information requirement is a proper tool to manage scare network resources. Previous works focus on Vickrey auction which is incentive compatible in classic auction theory. In the beginning of this paper, the faults of the most representative auction-based mechanisms are discussed. And then a new method called uniform-price auction (UPA), which has the simplest auction rule is proposed and it's incentive compatibility in the network environment is also proved. Finally, the basic mode is extended to support applications which require minimum bandwidth guarantees for a given time period by introducing derivative market, and a market mechanism for network resource allocation which is predictable, riskless, and simple for end-users is completed.

Optimal design of FIR triplet halfband filter bank and application in image coding.

PubMed

Kha, H H; Tuan, H D; Nguyen, T Q

2011-02-01

This correspondence proposes an efficient semidefinite programming (SDP) method for the design of a class of linear phase finite impulse response triplet halfband filter banks whose filters have optimal frequency selectivity for a prescribed regularity order. The design problem is formulated as the minimization of the least square error subject to peak error constraints and regularity constraints. By using the linear matrix inequality characterization of the trigonometric semi-infinite constraints, it can then be exactly cast as a SDP problem with a small number of variables and, hence, can be solved efficiently. Several design examples of the triplet halfband filter bank are provided for illustration and comparison with previous works. Finally, the image coding performance of the filter bank is presented.

An experimental study of a turbulent boundary layer in the trailing edge region of a circulation-control airfoil

NASA Technical Reports Server (NTRS)

Heinemann, K.; Brown, Jeff

1992-01-01

This report discusses progress made on NASA Cooperative Agreement NCC2-545, 'An Experimental Study of a Turbulent Boundary Layer in the Trailing-Edge Region of a Circulation-Control Airfoil' during the period 9/1/91 through 9/30/92. The study features 2-component laser Doppler velocimeter (LDV) measurements in the trailing edge and wake regions of a generic 2-dimensional circulation-control model. The final experimental phase of the study will be carried out in the Ames High Reynolds Number Channel 2 (HRC2) transonic blow-down-facility. During the 13-month period covered by this report, work continued on the development of the near-wall laser Doppler velocimeter (LDV) described in previous reports.

Dual light field and polarization imaging using CMOS diffractive image sensors.

PubMed

Jayasuriya, Suren; Sivaramakrishnan, Sriram; Chuang, Ellen; Guruaribam, Debashree; Wang, Albert; Molnar, Alyosha

2015-05-15

In this Letter we present, to the best of our knowledge, the first integrated CMOS image sensor that can simultaneously perform light field and polarization imaging without the use of external filters or additional optical elements. Previous work has shown how photodetectors with two stacks of integrated metal gratings above them (called angle sensitive pixels) diffract light in a Talbot pattern to capture four-dimensional light fields. We show, in addition to diffractive imaging, that these gratings polarize incoming light and characterize the response of these sensors to polarization and incidence angle. Finally, we show two applications of polarization imaging: imaging stress-induced birefringence and identifying specular reflections in scenes to improve light field algorithms for these scenes.

Faster Trees: Strategies for Accelerated Training and Prediction of Random Forests for Classification of Polsar Images

NASA Astrophysics Data System (ADS)

Hänsch, Ronny; Hellwich, Olaf

2018-04-01

Random Forests have continuously proven to be one of the most accurate, robust, as well as efficient methods for the supervised classification of images in general and polarimetric synthetic aperture radar data in particular. While the majority of previous work focus on improving classification accuracy, we aim for accelerating the training of the classifier as well as its usage during prediction while maintaining its accuracy. Unlike other approaches we mainly consider algorithmic changes to stay as much as possible independent of platform and programming language. The final model achieves an approximately 60 times faster training and a 500 times faster prediction, while the accuracy is only marginally decreased by roughly 1 %.

Dynamics of Conflicts in Wikipedia

PubMed Central

Yasseri, Taha; Sumi, Robert; Rung, András; Kornai, András; Kertész, János

2012-01-01

In this work we study the dynamical features of editorial wars in Wikipedia (WP). Based on our previously established algorithm, we build up samples of controversial and peaceful articles and analyze the temporal characteristics of the activity in these samples. On short time scales, we show that there is a clear correspondence between conflict and burstiness of activity patterns, and that memory effects play an important role in controversies. On long time scales, we identify three distinct developmental patterns for the overall behavior of the articles. We are able to distinguish cases eventually leading to consensus from those cases where a compromise is far from achievable. Finally, we analyze discussion networks and conclude that edit wars are mainly fought by few editors only. PMID:22745683

Analysis, calculation and utilization of the k-balance attribute in interdependent networks

NASA Astrophysics Data System (ADS)

Liu, Zheng; Li, Qing; Wang, Dan; Xu, Mingwei

2018-05-01

Interdependent networks, where two networks depend on each other, are becoming more and more significant in modern systems. From previous work, it can be concluded that interdependent networks are more vulnerable than a single network. The robustness in interdependent networks deserves special attention. In this paper, we propose a metric of robustness from a new perspective-the balance. First, we define the balance-coefficient of the interdependent system. Based on precise analysis and derivation, we prove some significant theories and provide an efficient algorithm to compute the balance-coefficient. Finally, we propose an optimal solution to reduce the balance-coefficient to enhance the robustness of the given system. Comprehensive experiments confirm the efficiency of our algorithms.

Vehicle Maneuver Detection with Accelerometer-Based Classification.

PubMed

Cervantes-Villanueva, Javier; Carrillo-Zapata, Daniel; Terroso-Saenz, Fernando; Valdes-Vela, Mercedes; Skarmeta, Antonio F

2016-09-29

In the mobile computing era, smartphones have become instrumental tools to develop innovative mobile context-aware systems. In that sense, their usage in the vehicular domain eases the development of novel and personal transportation solutions. In this frame, the present work introduces an innovative mechanism to perceive the current kinematic state of a vehicle on the basis of the accelerometer data from a smartphone mounted in the vehicle. Unlike previous proposals, the introduced architecture targets the computational limitations of such devices to carry out the detection process following an incremental approach. For its realization, we have evaluated different classification algorithms to act as agents within the architecture. Finally, our approach has been tested with a real-world dataset collected by means of the ad hoc mobile application developed.

Pharmacokinetic Studies of Chinese Medicinal Herbs Using an Automated Blood Sampling System and Liquid Chromatography-mass Spectrometry.

PubMed

Wu, Yu-Tse; Wu, Ming-Tsang; Lin, Chia-Chun; Chien, Chao-Feng; Tsai, Tung-Hu

2012-01-01

The safety of herbal products is one of the major concerns for the modernization of traditional Chinese medicine, and pharmacokinetic data of medicinal herbs guide us to design the rational use of the herbal formula. This article reviews the advantages of the automated blood sampling (ABS) systems for pharmacokinetic studies. In addition, three commonly used sample preparative methods, protein precipitation, liquid-liquid extraction and solid-phase extraction, are introduced. Furthermore, the definition, causes and evaluation of matrix effects in liquid chromatography-mass spectrometry (LC/MS) analysis are demonstrated. Finally, we present our previous works as practical examples of the application of ABS systems and LC/MS for the pharmacokinetic studies of Chinese medicinal herbs.

Resonant Ultrasound Spectroscopy studies of Berea sandstone at high temperature

DOE PAGES

Davis, Eric S.; Sturtevant, Blake T.; Sinha, Dipen N.; ...

2016-09-04

Resonant Ultrasound Spectroscopy was used in this paper to determine the elastic moduli of Berea sandstone from room temperature to 478 K. Sandstone is a common component of oil reservoirs, and the temperature range was chosen to be representative of typical downhole conditions, down to about 8 km. In agreement with previous works, Berea sandstone was found to be relatively soft with a bulk modulus of approximately 6 GPa as compared to 37.5 GPa for α-quartz at room temperature and pressure. Finally, it was found that Berea sandstone undergoes a ~17% softening in bulk modulus between room temperature and 385more » K, followed by an abnormal behavior of similar stiffening between 385 K and 478 K.« less

Resonant Ultrasound Spectroscopy studies of Berea sandstone at high temperature

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davis, Eric S.; Sturtevant, Blake T.; Sinha, Dipen N.

Resonant Ultrasound Spectroscopy was used in this paper to determine the elastic moduli of Berea sandstone from room temperature to 478 K. Sandstone is a common component of oil reservoirs, and the temperature range was chosen to be representative of typical downhole conditions, down to about 8 km. In agreement with previous works, Berea sandstone was found to be relatively soft with a bulk modulus of approximately 6 GPa as compared to 37.5 GPa for α-quartz at room temperature and pressure. Finally, it was found that Berea sandstone undergoes a ~17% softening in bulk modulus between room temperature and 385more » K, followed by an abnormal behavior of similar stiffening between 385 K and 478 K.« less

Linear feature extraction from radar imagery: SBIR (Small Business Innovative Research) phase 2, option 1

NASA Astrophysics Data System (ADS)

Conner, Gary D.; Milgram, David L.; Lawton, Daryl T.; McConnell, Christopher C.

1988-04-01

The goal of this effort is to develop and demonstrate prototype processing capabilities for a knowledge-based system to automatically extract and analyze linear features from synthetic aperture radar (SAR) imagery. This effort constitutes Phase 2 funding through the Defense Small Business Innovative Research (SBIR) Program. Previous work examined the feasibility of the technology issues involved in the development of an automatedlinear feature extraction system. This Option 1 Final Report documents this examination and the technologies involved in automating this image understanding task. In particular, it reports on a major software delivery containing an image processing algorithmic base, a perceptual structures manipulation package, a preliminary hypothesis management framework and an enhanced user interface.

Empirical calibration of the near-infrared Ca II triplet - III. Fitting functions

NASA Astrophysics Data System (ADS)

Cenarro, A. J.; Gorgas, J.; Cardiel, N.; Vazdekis, A.; Peletier, R. F.

2002-02-01

Using a near-infrared stellar library of 706 stars with a wide coverage of atmospheric parameters, we study the behaviour of the CaII triplet strength in terms of effective temperature, surface gravity and metallicity. Empirical fitting functions for recently defined line-strength indices, namely CaT*, CaT and PaT, are provided. These functions can be easily implemented into stellar population models to provide accurate predictions for integrated CaII strengths. We also present a thorough study of the various error sources and their relation to the residuals of the derived fitting functions. Finally, the derived functional forms and the behaviour of the predicted CaII are compared with those of previous works in the field.

New Ground Truth Capability from InSAR Time Series Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Buckley, S; Vincent, P; Yang, D

2005-07-13

We demonstrate that next-generation interferometric synthetic aperture radar (InSAR) processing techniques applied to existing data provide rich InSAR ground truth content for exploitation in seismic source identification. InSAR time series analyses utilize tens of interferograms and can be implemented in different ways. In one such approach, conventional InSAR displacement maps are inverted in a final post-processing step. Alternatively, computationally intensive data reduction can be performed with specialized InSAR processing algorithms. The typical final result of these approaches is a synthesized set of cumulative displacement maps. Examples from our recent work demonstrate that these InSAR processing techniques can provide appealing newmore » ground truth capabilities. We construct movies showing the areal and temporal evolution of deformation associated with previous nuclear tests. In other analyses, we extract time histories of centimeter-scale surface displacement associated with tunneling. The potential exists to identify millimeter per year surface movements when sufficient data exists for InSAR techniques to isolate and remove phase signatures associated with digital elevation model errors and the atmosphere.« less

DNA Packaging in Bacteriophage: Is Twist Important?

PubMed Central

Spakowitz, Andrew James; Wang, Zhen-Gang

2005-01-01

We study the packaging of DNA into a bacteriophage capsid using computer simulation, specifically focusing on the potential impact of twist on the final packaged conformation. We perform two dynamic simulations of packaging a polymer chain into a spherical confinement: one where the chain end is rotated as it is fed, and one where the chain is fed without end rotation. The final packaged conformation exhibits distinct differences in these two cases: the packaged conformation from feeding with rotation exhibits a spool-like character that is consistent with experimental and previous theoretical work, whereas feeding without rotation results in a folded conformation inconsistent with a spool conformation. The chain segment density shows a layered structure, which is more pronounced for packaging with rotation. However, in both cases, the conformation is marked by frequent jumps of the polymer chain from layer to layer, potentially influencing the ability to disentangle during subsequent ejection. Ejection simulations with and without Brownian forces show that Brownian forces are necessary to achieve complete ejection of the polymer chain in the absence of external forces. PMID:15805174

DNA packaging in bacteriophage: is twist important?

PubMed

Spakowitz, Andrew James; Wang, Zhen-Gang

2005-06-01

We study the packaging of DNA into a bacteriophage capsid using computer simulation, specifically focusing on the potential impact of twist on the final packaged conformation. We perform two dynamic simulations of packaging a polymer chain into a spherical confinement: one where the chain end is rotated as it is fed, and one where the chain is fed without end rotation. The final packaged conformation exhibits distinct differences in these two cases: the packaged conformation from feeding with rotation exhibits a spool-like character that is consistent with experimental and previous theoretical work, whereas feeding without rotation results in a folded conformation inconsistent with a spool conformation. The chain segment density shows a layered structure, which is more pronounced for packaging with rotation. However, in both cases, the conformation is marked by frequent jumps of the polymer chain from layer to layer, potentially influencing the ability to disentangle during subsequent ejection. Ejection simulations with and without Brownian forces show that Brownian forces are necessary to achieve complete ejection of the polymer chain in the absence of external forces.

Do End-of-Rotation and End-of-Shift Assessments Inform Clinical Competency Committees’ (CCC) Decisions?

PubMed Central

Regan, Linda; Cope, Leslie; Omron, Rodney; Bright, Leah; Bayram, Jamil D.

2018-01-01

Introduction Clinical Competency Committees (CCC) require reliable, objective data to inform decisions regarding assignment of milestone proficiency levels, which must be reported to the Accreditation Council for Graduate Medical Education. After the development of two new assessment methods, the end-of-shift (EOS) assessment and the end-of-rotation (EOR) assessment, we sought to evaluate their performance. We report data on the concordance between these assessments, as well as how each informs the final proficiency level determined in biannual CCC meetings. We hypothesized that there would be a high concordance level between the two assessment methods, including concordance of both the EOS and EOR with the final proficiency level designation by the CCC. Methods The residency program is an urban academic four-year emergency medicine residency with 48 residents. After their shifts in the emergency department (ED), residents handed out EOS assessment forms asking about individual milestones from 15 subcompetencies to supervising physicians, as well as triggered electronic EOR-doctor (EORd) assessments to supervising doctors and EOR-nurse (EORn) to nurses they had worked with after each two-week ED block. EORd assessments contained the full proficiency level scale from 16 subcompetencies, while EORn assessments contained four subcompetencies. Data reports were generated after each six-month assessment period and data was aggregated. We calculated Spearman’s rank order correlations for correlations between assessment types and between assessments and final CCC proficiency levels. Results Over 24 months, 5,234 assessments were completed. The strongest correlations with CCC proficiency levels were the EORd for the immediate six-month assessment period prior (rs 0.71–0.84), and the CCC proficiency levels from the previous six-months (rs 0.83–0.92). EOS assessments had weaker correlations (rs 0.49 to 0.62), as did EORn (rs 0.4 to 0.73). Conclusion End-of-rotation assessments completed by supervising doctors are most highly correlated with final CCC proficiency level designations, while end-of-shift assessments and end-of-rotation assessments by nurses did not correlate strongly with final CCC proficiency levels, both with overestimation of levels noted. Every level of proficiency the CCC assigned appears to be highly correlated with the designated level in the immediate six-month period, perhaps implying CCC members are biased by previous level assignments. PMID:29383066

Do End-of-Rotation and End-of-Shift Assessments Inform Clinical Competency Committees' (CCC) Decisions?

PubMed

Regan, Linda; Cope, Leslie; Omron, Rodney; Bright, Leah; Bayram, Jamil D

2018-01-01

Clinical Competency Committees (CCC) require reliable, objective data to inform decisions regarding assignment of milestone proficiency levels, which must be reported to the Accreditation Council for Graduate Medical Education. After the development of two new assessment methods, the end-of-shift (EOS) assessment and the end-of-rotation (EOR) assessment, we sought to evaluate their performance. We report data on the concordance between these assessments, as well as how each informs the final proficiency level determined in biannual CCC meetings. We hypothesized that there would be a high concordance level between the two assessment methods, including concordance of both the EOS and EOR with the final proficiency level designation by the CCC. The residency program is an urban academic four-year emergency medicine residency with 48 residents. After their shifts in the emergency department (ED), residents handed out EOS assessment forms asking about individual milestones from 15 subcompetencies to supervising physicians, as well as triggered electronic EOR-doctor (EORd) assessments to supervising doctors and EOR-nurse (EORn) to nurses they had worked with after each two-week ED block. EORd assessments contained the full proficiency level scale from 16 subcompetencies, while EORn assessments contained four subcompetencies. Data reports were generated after each six-month assessment period and data was aggregated. We calculated Spearman's rank order correlations for correlations between assessment types and between assessments and final CCC proficiency levels. Over 24 months, 5,234 assessments were completed. The strongest correlations with CCC proficiency levels were the EORd for the immediate six-month assessment period prior (r s 0.71-0.84), and the CCC proficiency levels from the previous six-months (r s 0.83-0.92). EOS assessments had weaker correlations (r s 0.49 to 0.62), as did EORn (r s 0.4 to 0.73). End-of-rotation assessments completed by supervising doctors are most highly correlated with final CCC proficiency level designations, while end-of-shift assessments and end-of-rotation assessments by nurses did not correlate strongly with final CCC proficiency levels, both with overestimation of levels noted. Every level of proficiency the CCC assigned appears to be highly correlated with the designated level in the immediate six-month period, perhaps implying CCC members are biased by previous level assignments.

25 CFR 256.20 - How are these repairs or construction trades persons, home building contractors, or construction...

Code of Federal Regulations, 2010 CFR

2010-04-01

... statement of work, which identifies the work to be performed. The appropriate contracting office uses the... completing the project as advertised. (a) Payments to the winning bidder are negotiated in the contract and... the completed work. (2) Final payment will be made after final inspection and after all provisions of...

Retrieval and Monitoring Processes during Visual Working Memory: An ERP Study of the Benefit of Visual Semantics

PubMed Central

Orme, Elizabeth; Brown, Louise A.; Riby, Leigh M.

2017-01-01

In this study, we examined electrophysiological indices of episodic remembering whilst participants recalled novel shapes, with and without semantic content, within a visual working memory paradigm. The components of interest were the parietal episodic (PE; 400–800 ms) and late posterior negativity (LPN; 500–900 ms), as these have previously been identified as reliable markers of recollection and post-retrieval monitoring, respectively. Fifteen young adults completed a visual matrix patterns task, assessing memory for low and high semantic visual representations. Matrices with either low semantic or high semantic content (containing familiar visual forms) were briefly presented to participants for study (1500 ms), followed by a retention interval (6000 ms) and finally a same/different recognition phase. The event-related potentials of interest were tracked from the onset of the recognition test stimuli. Analyses revealed equivalent amplitude for the earlier PE effect for the processing of both low and high semantic stimulus types. However, the LPN was more negative-going for the processing of the low semantic stimuli. These data are discussed in terms of relatively ‘pure’ and complete retrieval of high semantic items, where support can readily be recruited from semantic memory. However, for the low semantic items additional executive resources, as indexed by the LPN, are recruited when memory monitoring and uncertainty exist in order to recall previously studied items more effectively. PMID:28725203

Retrieval and Monitoring Processes during Visual Working Memory: An ERP Study of the Benefit of Visual Semantics.

PubMed

Orme, Elizabeth; Brown, Louise A; Riby, Leigh M

2017-01-01

In this study, we examined electrophysiological indices of episodic remembering whilst participants recalled novel shapes, with and without semantic content, within a visual working memory paradigm. The components of interest were the parietal episodic (PE; 400-800 ms) and late posterior negativity (LPN; 500-900 ms), as these have previously been identified as reliable markers of recollection and post-retrieval monitoring, respectively. Fifteen young adults completed a visual matrix patterns task, assessing memory for low and high semantic visual representations. Matrices with either low semantic or high semantic content (containing familiar visual forms) were briefly presented to participants for study (1500 ms), followed by a retention interval (6000 ms) and finally a same/different recognition phase. The event-related potentials of interest were tracked from the onset of the recognition test stimuli. Analyses revealed equivalent amplitude for the earlier PE effect for the processing of both low and high semantic stimulus types. However, the LPN was more negative-going for the processing of the low semantic stimuli. These data are discussed in terms of relatively 'pure' and complete retrieval of high semantic items, where support can readily be recruited from semantic memory. However, for the low semantic items additional executive resources, as indexed by the LPN, are recruited when memory monitoring and uncertainty exist in order to recall previously studied items more effectively.

Hierarchical Recognition Scheme for Human Facial Expression Recognition Systems

PubMed Central

Siddiqi, Muhammad Hameed; Lee, Sungyoung; Lee, Young-Koo; Khan, Adil Mehmood; Truc, Phan Tran Ho

2013-01-01

Over the last decade, human facial expressions recognition (FER) has emerged as an important research area. Several factors make FER a challenging research problem. These include varying light conditions in training and test images; need for automatic and accurate face detection before feature extraction; and high similarity among different expressions that makes it difficult to distinguish these expressions with a high accuracy. This work implements a hierarchical linear discriminant analysis-based facial expressions recognition (HL-FER) system to tackle these problems. Unlike the previous systems, the HL-FER uses a pre-processing step to eliminate light effects, incorporates a new automatic face detection scheme, employs methods to extract both global and local features, and utilizes a HL-FER to overcome the problem of high similarity among different expressions. Unlike most of the previous works that were evaluated using a single dataset, the performance of the HL-FER is assessed using three publicly available datasets under three different experimental settings: n-fold cross validation based on subjects for each dataset separately; n-fold cross validation rule based on datasets; and, finally, a last set of experiments to assess the effectiveness of each module of the HL-FER separately. Weighted average recognition accuracy of 98.7% across three different datasets, using three classifiers, indicates the success of employing the HL-FER for human FER. PMID:24316568

Building Extraction from Remote Sensing Data Using Fully Convolutional Networks

NASA Astrophysics Data System (ADS)

Bittner, K.; Cui, S.; Reinartz, P.

2017-05-01

Building detection and footprint extraction are highly demanded for many remote sensing applications. Though most previous works have shown promising results, the automatic extraction of building footprints still remains a nontrivial topic, especially in complex urban areas. Recently developed extensions of the CNN framework made it possible to perform dense pixel-wise classification of input images. Based on these abilities we propose a methodology, which automatically generates a full resolution binary building mask out of a Digital Surface Model (DSM) using a Fully Convolution Network (FCN) architecture. The advantage of using the depth information is that it provides geometrical silhouettes and allows a better separation of buildings from background as well as through its invariance to illumination and color variations. The proposed framework has mainly two steps. Firstly, the FCN is trained on a large set of patches consisting of normalized DSM (nDSM) as inputs and available ground truth building mask as target outputs. Secondly, the generated predictions from FCN are viewed as unary terms for a Fully connected Conditional Random Fields (FCRF), which enables us to create a final binary building mask. A series of experiments demonstrate that our methodology is able to extract accurate building footprints which are close to the buildings original shapes to a high degree. The quantitative and qualitative analysis show the significant improvements of the results in contrast to the multy-layer fully connected network from our previous work.

Item generation and pilot testing of the Comprehensive Professional Behaviours Development Log.

PubMed

Bartlett, Doreen J; Lucy, S Deborah; Bisbee, Leslie

2006-01-01

The purpose of this project was to generate and refine criteria for professional behaviors previously identified to be important for physical therapy practice and to develop and pilot test a new instrument, which we have called the Comprehensive Professional Behaviours Development Log (CPBDL). Items were generated from our previous work, the work of Warren May and his colleagues, a competency profile for entry-level physical therapists, our regulatory code of ethics, and an evaluation of clinical performance. A group of eight people, including recent graduates, clinical instructors and professional practice leaders, and faculty members, refined the items in two iterations using the Delphi process. The CPBDL contains nine key professional behaviors with a range of nine to 23 specific behavioral criteria for individuals to reflect on and to indicate the consistency of performance from a selection of "not at all," "sometimes," and "always" response options. Pilot testing with a group of 42 students in the final year of our entry-to-practice curriculum indicated that the criteria were clear, the measure was feasible to complete in a reasonable time frame, and there were no ceiling or floor effects. We believe that others, including health care educators and practicing professionals, might be interested in adapting the CPBDL in their own settings to enhance the professional behaviors of either students in preparation for entry to practice or clinicians wishing to demonstrate continuing competency to professional regulatory bodies.

Uplift sequence of the Andes at 30°S: Insights from sedimentology and U/Pb dating of synorogenic deposits

NASA Astrophysics Data System (ADS)

Suriano, J.; Mardonez, D.; Mahoney, J. B.; Mescua, J. F.; Giambiagi, L. B.; Kimbrough, D.; Lossada, A.

2017-04-01

The South Central Andes at 30°S represent a key area to understand the Andes geodynamics as it is in the middle of the flat slab segment and all the morphotectonic units of the Central Andes are well developed. This work is focused in the proximal synorogenic deposits of the Western Precordillera, in the La Tranca valley, in order to unravel the uplift sequence of this belt. Nine facies associations were recognized; most of them represent piedmont facies with local provenance from Precordillera and were deposited in the wedge-top depozone, as is expected for proximal sinorogenic deposits. However there are intercalations of transference fluvial systems, which show mixed provenance indicating that Permo-Triassic igneous rocks were already exposed to the west (Frontal Cordillera). There are also lacustrine deposits which are interpreted as the result of damming by fault activity at east of the studied basin. Finally, two maximum depositional ages at ca. 11 Ma and 8 Ma of these deposits indicate that the onset of uplift of the Precordillera at 30°S is little older than 11 Ma. These data change two previous ideas about the evolution of the Precordillera: its uplift at 30° S is younger than proposed by previous works and it is nearly synchronous along strike.

Shell Extracts from the Marine Bivalve Pecten maximus Regulate the Synthesis of Extracellular Matrix in Primary Cultured Human Skin Fibroblasts

PubMed Central

Latire, Thomas; Legendre, Florence; Bigot, Nicolas; Carduner, Ludovic; Kellouche, Sabrina; Bouyoucef, Mouloud; Carreiras, Franck; Marin, Frédéric; Lebel, Jean-Marc; Galéra, Philippe; Serpentini, Antoine

2014-01-01

Mollusc shells are composed of more than 95% calcium carbonate and less than 5% of an organic matrix consisting mostly of proteins, glycoproteins and polysaccharides. Previous studies have elucidated the biological activities of the shell matrices from bivalve molluscs on skin, especially on the expression of the extracellular matrix components of fibroblasts. In this work, we have investigated the potential biological activities of shell matrix components extracted from the shell of the scallop Pecten maximus on human fibroblasts in primary culture. Firstly, we demonstrated that shell matrix components had different effects on general cellular activities. Secondly, we have shown that the shell matrix components stimulate the synthesis of type I and III collagens, as well as that of sulphated GAGs. The increased expression of type I collagen is likely mediated by the recruitment of transactivating factors (Sp1, Sp3 and human c-Krox) in the −112/−61 bp COL1A1 promoter region. Finally, contrarily to what was obtained in previous works, we demonstrated that the scallop shell extracts have only a small effect on cell migration during in vitro wound tests and have no effect on cell proliferation. Thus, our research emphasizes the potential use of shell matrix of Pecten maximus for dermo-cosmetic applications. PMID:24949635

Projection specificity in heterogeneous locus coeruleus cell populations: implications for learning and memory

PubMed Central

Uematsu, Akira; Tan, Bao Zhen

2015-01-01

Noradrenergic neurons in the locus coeruleus (LC) play a critical role in many functions including learning and memory. This relatively small population of cells sends widespread projections throughout the brain including to a number of regions such as the amygdala which is involved in emotional associative learning and the medial prefrontal cortex which is important for facilitating flexibility when learning rules change. LC noradrenergic cells participate in both of these functions, but it is not clear how this small population of neurons modulates these partially distinct processes. Here we review anatomical, behavioral, and electrophysiological studies to assess how LC noradrenergic neurons regulate these different aspects of learning and memory. Previous work has demonstrated that subpopulations of LC noradrenergic cells innervate specific brain regions suggesting heterogeneity of function in LC neurons. Furthermore, noradrenaline in mPFC and amygdala has distinct effects on emotional learning and cognitive flexibility. Finally, neural recording data show that LC neurons respond during associative learning and when previously learned task contingencies change. Together, these studies suggest a working model in which distinct and potentially opposing subsets of LC neurons modulate particular learning functions through restricted efferent connectivity with amygdala or mPFC. This type of model may provide a general framework for understanding other neuromodulatory systems, which also exhibit cell type heterogeneity and projection specificity. PMID:26330494

Changes in the Influence of Alcohol-Paired Stimuli on Alcohol Seeking across Extended Training

PubMed Central

Corbit, Laura H.; Janak, Patricia H.

2016-01-01

Previous work has demonstrated that goal-directed control of alcohol-seeking and other drug-related behaviors is reduced following extended self-administration and drug exposure. Here, we examined how the magnitude of stimulus influences on responding changes across similar training and drug exposure. Rats self-administered alcohol or sucrose for 2 or 8 weeks. Previous work has shown that 8 weeks, but not 2 weeks of self-administration produces habitual alcohol seeking. Next, all animals received equivalent Pavlovian conditioning sessions where a discrete stimulus predicted the delivery of alcohol or sucrose. Finally, the impact of the stimuli on ongoing instrumental responding was examined in a Pavlovian–instrumental transfer (PIT) test. While a significant PIT effect was observed following 2 weeks of either alcohol or sucrose self-administration, the magnitude of this effect was greater following 8 weeks of training. The specificity of the PIT effect appeared unchanged by extended training. While it is well established that evaluation of the outcome of responding contributes less to behavioral control following extended training and/or drug exposure, our data indicate that reward–predictive stimuli have a stronger contribution to responding after extended training. Together, these findings provide insight into the factors that control behavior after extended drug use, which will be important for developing effective methods for controlling and ideally reducing these behaviors. PMID:27777560

More on heavy tetraquarks in lattice QCD at almost physical pion mass

NASA Astrophysics Data System (ADS)

Francis, Anthony; Hudspith, Renwick J.; Lewis, Randy; Maltman, Kim

2018-03-01

We report on our progress in studying exotic, heavy tetraquark states, qq' Q̅Q̅'. Using publicly available dynamical nf = 2 + 1 Wilson-Clover gauge configurations, generated by the PACS-CS collaboration, with pion masses ≃ 164, 299 and 415 MeV, we extend our previous analysis to heavy quark components containing heavier than physical bottom quarks Q̅Q̅' = b̅'b̅' or Q̅Q̅' = b̅b̅', charm and bottom quarks c̅b̅ and also only charm quarks c̅ c̅. Throughout we employ NRQCD and relativistic heavy quarks for the heavier than bottom, bottom and charm quarks. Using our previously established diquark-antidiquark and meson-meson operator basis we comment in particular on the dependence of the binding energy on the mass of the heavy quark component Q̅Q̅, with heavy quarks ranging from mQ = 0:85… 6.3 · mb. In the heavy flavor non-degenerate case, Q̅Q̅', and especially for the tetraquark channel udc̅d̅, we extend our work to utilize a 3 × 3 GEVP to study the ground and threshold states thereby enabling a clear identification of possible binding. Finally, we present initial work on the Q̅Q̅' = c̅c̅ system where a much larger operator basis is available in comparison to flavor combinations with NRQCD quarks.

Discovery of Azurin-Like Anticancer Bacteriocins from Human Gut Microbiome through Homology Modeling and Molecular Docking against the Tumor Suppressor p53.

PubMed

Nguyen, Chuong; Nguyen, Van Duy

2016-01-01

Azurin from Pseudomonas aeruginosa is known anticancer bacteriocin, which can specifically penetrate human cancer cells and induce apoptosis. We hypothesized that pathogenic and commensal bacteria with long term residence in human body can produce azurin-like bacteriocins as a weapon against the invasion of cancers. In our previous work, putative bacteriocins have been screened from complete genomes of 66 dominant bacteria species in human gut microbiota and subsequently characterized by subjecting them as functional annotation algorithms with azurin as control. We have qualitatively predicted 14 putative bacteriocins that possessed functional properties very similar to those of azurin. In this work, we perform a number of quantitative and structure-based analyses including hydrophobic percentage calculation, structural modeling, and molecular docking study of bacteriocins of interest against protein p53, a cancer target. Finally, we have identified 8 putative bacteriocins that bind p53 in a same manner as p28-azurin and azurin, in which 3 peptides (p1seq16, p2seq20, and p3seq24) shared with our previous study and 5 novel ones (p1seq09, p2seq05, p2seq08, p3seq02, and p3seq17) discovered in the first time. These bacteriocins are suggested for further in vitro tests in different neoplastic line cells.

Discovery of Azurin-Like Anticancer Bacteriocins from Human Gut Microbiome through Homology Modeling and Molecular Docking against the Tumor Suppressor p53

PubMed Central

Nguyen, Chuong; Nguyen, Van Duy

2016-01-01

Azurin from Pseudomonas aeruginosa is known anticancer bacteriocin, which can specifically penetrate human cancer cells and induce apoptosis. We hypothesized that pathogenic and commensal bacteria with long term residence in human body can produce azurin-like bacteriocins as a weapon against the invasion of cancers. In our previous work, putative bacteriocins have been screened from complete genomes of 66 dominant bacteria species in human gut microbiota and subsequently characterized by subjecting them as functional annotation algorithms with azurin as control. We have qualitatively predicted 14 putative bacteriocins that possessed functional properties very similar to those of azurin. In this work, we perform a number of quantitative and structure-based analyses including hydrophobic percentage calculation, structural modeling, and molecular docking study of bacteriocins of interest against protein p53, a cancer target. Finally, we have identified 8 putative bacteriocins that bind p53 in a same manner as p28-azurin and azurin, in which 3 peptides (p1seq16, p2seq20, and p3seq24) shared with our previous study and 5 novel ones (p1seq09, p2seq05, p2seq08, p3seq02, and p3seq17) discovered in the first time. These bacteriocins are suggested for further in vitro tests in different neoplastic line cells. PMID:27239476

Achieving Consensus on Total Joint Replacement Trial Outcome Reporting Using the OMERACT Filter: Endorsement of the Final Core Domain Set for Total Hip and Total Knee Replacement Trials for Endstage Arthritis.

PubMed

Singh, Jasvinder A; Dowsey, Michelle M; Dohm, Michael; Goodman, Susan M; Leong, Amye L; Scholte Voshaar, Marieke M J H; Choong, Peter F

2017-11-01

Discussion and endorsement of the OMERACT total joint replacement (TJR) core domain set for total hip replacement (THR) and total knee replacement (TKR) for endstage arthritis; and next steps for selection of instruments. The OMERACT TJR working group met at the 2016 meeting at Whistler, British Columbia, Canada. We summarized the previous systematic reviews, the preliminary OMERACT TJR core domain set and results from previous surveys. We discussed preliminary core domains for TJR clinical trials, made modifications, and identified challenges with domain measurement. Working group participants (n = 26) reviewed, clarified, and endorsed each of the inner and middle circle domains and added a range of motion domain to the research agenda. TJR were limited to THR and TKR but included all endstage hip and knee arthritis refractory to medical treatment. Participants overwhelmingly endorsed identification and evaluation of top instruments mapping to the core domains (100%) and use of subscales of validated multidimensional instruments to measure core domains for the TJR clinical trial core measurement set (92%). An OMERACT core domain set for hip/knee TJR trials has been defined and we are selecting instruments to develop the TJR clinical trial core measurement set to serve as a common foundation for harmonizing measures in TJR clinical trials.

Biologically inspired information theory: Adaptation through construction of external reality models by living systems.

PubMed

Nakajima, Toshiyuki

2015-12-01

Higher animals act in the world using their external reality models to cope with the uncertain environment. Organisms that have not developed such information-processing organs may also have external reality models built in the form of their biochemical, physiological, and behavioral structures, acquired by natural selection through successful models constructed internally. Organisms subject to illusions would fail to survive in the material universe. How can organisms, or living systems in general, determine the external reality from within? This paper starts with a phenomenological model, in which the self constitutes a reality model developed through the mental processing of phenomena. Then, the it-from-bit concept is formalized using a simple mathematical model. For this formalization, my previous work on an algorithmic process is employed to constitute symbols referring to the external reality, called the inverse causality, with additional improvements to the previous work. Finally, as an extension of this model, the cognizers system model is employed to describe the self as one of many material entities in a world, each of which acts as a subject by responding to the surrounding entities. This model is used to propose a conceptual framework of information theory that can deal with both the qualitative (semantic) and quantitative aspects of the information involved in biological processes. Copyright © 2015 Elsevier Ltd. All rights reserved.

Interaction of S-layer proteins of Lactobacillus kefir with model membranes and cells.

PubMed

Hollmann, Axel; Delfederico, Lucrecia; Santos, Nuno C; Disalvo, E Anibal; Semorile, Liliana

2018-06-01

In previous works, it was shown that S-layer proteins from Lactobacillus kefir were able to recrystallize and stabilize liposomes, this feature reveling a great potential for developing liposomal-based carriers. Despite previous studies on this subject are important milestones, a number of questions remain unanswered. In this context, the feasibility of S-layer proteins as a biomaterial for drug delivery was evaluated in this work. First, S-layer proteins were fully characterized by electron microscopy, 2D-electrophoresis, and anionic exchange chromatography coupled with pulsed amperometric detection (HPAEC-PAD). Afterward, interactions of S-layer proteins with model lipid membranes were evaluated, showing that proteins adsorb to the lipid surface following a non-fickean or anomalous diffusion, when positively charged lipid were employed, suggesting that electrostatic interaction is a key factor in the recrystallization process on these proteins. Finally, the interaction of S-layer coated liposomes with Caco-2 cell line was assessed: First, cytotoxicity of formulations was tested showing no cytotoxic effects in S-layer coated vesicles. Second, by flow cytometry, it was observed an increased ability to transfer cargo molecules into Caco-2 cells from S-layer coated liposomes in comparison to control ones. All data put together, supports the idea that a combination of adhesive properties of S-layer proteins concomitant with higher stability of S-layer coated liposomes represents an exciting starting point in the development of new drug carriers.

Spread of information and infection on finite random networks

NASA Astrophysics Data System (ADS)

Isham, Valerie; Kaczmarska, Joanna; Nekovee, Maziar

2011-04-01

The modeling of epidemic-like processes on random networks has received considerable attention in recent years. While these processes are inherently stochastic, most previous work has been focused on deterministic models that ignore important fluctuations that may persist even in the infinite network size limit. In a previous paper, for a class of epidemic and rumor processes, we derived approximate models for the full probability distribution of the final size of the epidemic, as opposed to only mean values. In this paper we examine via direct simulations the adequacy of the approximate model to describe stochastic epidemics and rumors on several random network topologies: homogeneous networks, Erdös-Rényi (ER) random graphs, Barabasi-Albert scale-free networks, and random geometric graphs. We find that the approximate model is reasonably accurate in predicting the probability of spread. However, the position of the threshold and the conditional mean of the final size for processes near the threshold are not well described by the approximate model even in the case of homogeneous networks. We attribute this failure to the presence of other structural properties beyond degree-degree correlations, and in particular clustering, which are present in any finite network but are not incorporated in the approximate model. In order to test this “hypothesis” we perform additional simulations on a set of ER random graphs where degree-degree correlations and clustering are separately and independently introduced using recently proposed algorithms from the literature. Our results show that even strong degree-degree correlations have only weak effects on the position of the threshold and the conditional mean of the final size. On the other hand, the introduction of clustering greatly affects both the position of the threshold and the conditional mean. Similar analysis for the Barabasi-Albert scale-free network confirms the significance of clustering on the dynamics of rumor spread. For this network, though, with its highly skewed degree distribution, the addition of positive correlation had a much stronger effect on the final size distribution than was found for the simple random graph.

Health effects of wind turbines in working environments - a scoping review.

PubMed

Freiberg, Alice; Schefter, Christiane; Girbig, Maria; Murta, Vanise Cleto; Seidler, Andreas

2018-01-23

Objectives The wind industry is a growing economic sector, yet there is no overview summarizing all exposures emanating from wind turbines throughout their life cycle that may pose a risk for workers` health. The aim of this scoping review was to survey and outline the body of evidence around the health effects of wind turbines in working environments in order to identify research gaps and to highlight the need for further research. Methods A scoping review with a transparent and systematic procedure was conducted using a comprehensive search strategy. Two independent reviewers conducted most of the review steps. Results Twenty articles of varying methodical quality were included. Our findings of the included studies indicate that substances used in rotor blade manufacture (epoxy resin and styrene) cause skin disorders, and respectively, respiratory ailments and eye complaints; exposure to onshore wind turbine noise leads to annoyance, sleep disorders, and lowered general health; finally working in the wind industry is associated with a considerable accident rate, resulting in injuries or fatalities. Conclusions Due to the different work activities during the life cycle of a wind turbine and the distinction between on- and offshore work, there are no specific overall health effects of working in the wind sector. Previous research has primarily focused on evaluating the effects of working in the wind industry on skin disorders, accidents, and noise consequences. There is a need for further research, particularly in studying the effect of wind turbine work on psychological and musculoskeletal disorders, work-related injury and accident rates, and health outcomes in later life cycle phases.

Improve Tracking of Workplace Injuries and Illnesses. Final rule.

PubMed

2016-05-12

OSHA is issuing a final rule to revise its Recording and Reporting Occupational Injuries and Illnesses regulation. The final rule requires employers in certain industries to electronically submit to OSHA injury and illness data that employers are already required to keep under existing OSHA regulations. The frequency and content of these establishment-specific submissions is set out in the final rule and is dependent on the size and industry of the employer. OSHA intends to post the data from these submissions on a publicly accessible Web site. OSHA does not intend to post any information on the Web site that could be used to identify individual employees. The final rule also amends OSHA's recordkeeping regulation to update requirements on how employers inform employees to report work-related injuries and illnesses to their employer. The final rule requires employers to inform employees of their right to report work-related injuries and illnesses free from retaliation; clarifies the existing implicit requirement that an employer's procedure for reporting work-related injuries and illnesses must be reasonable and not deter or discourage employees from reporting; and incorporates the existing statutory prohibition on retaliating against employees for reporting work-related injuries or illnesses. The final rule also amends OSHA's existing recordkeeping regulation to clarify the rights of employees and their representatives to access the injury and illness records.

Does voltage predict return to work and neuropsychiatric sequelae following electrical burn injury?

PubMed

Chudasama, Shruti; Goverman, Jeremy; Donaldson, Jeffrey H; van Aalst, John; Cairns, Bruce A; Hultman, Charles Scott

2010-05-01

Voltage has historically guided the acute management and long-term prognosis of physical morbidity in electrical injury patients; however, few large studies exist that include neuropsychiatric morbidity in final outcome analysis. This review compares high (>1000 V) to low (<1000 V) voltage injuries, focusing on return to work and neuropsychiatric sequelae following electrical burn injury. Patients with electrical injuries admitted to the University of North Carolina Jaycee Burn Center between 2000 and 2005 were prospectively entered into a trauma database, then retrospectively reviewed. Patients were divided into 4 cohorts: high voltage (>1000 V), low voltage (<1000 V), flash arc, and lightning. Demographics, hospital course, and follow-up were recorded to determine physical and neuropsychiatric morbidity. Differences among cohorts were tested for statistical significance. Over 5 years, 2548 patients were admitted to the burn center, including 115 patients with electrical injuries. There were 110 males and 5 females, with a mean age of 35 years (range, 0.75-65 years). The cause of the electrical injury was high voltage in 60 cases, low voltage in 25 cases, flash arc in 29 cases and lightning in 1 case. The mean total body surface area burn was 8% (range, 0%-52%). The etiology was work-related electrical injury in 85 patients. Mean follow-up period was 352 days with 13 (11%) patients lost to follow-up. Patients with high voltage injuries had significantly larger total body surface area burn, longer ICU stays, longer hospitalizations, and significantly higher rates of fasciotomy, amputation, nerve decompression and outpatient reconstruction, with 4 cases of renal failure and 2 deaths. In spite of these differences, high and low voltage groups experienced similar rates of neuropsychiatric sequelae, limited return to work and delays in return to work. Final impairment ratings for the high and low voltage groups were 17.5% and 5.3%, respectively. Electrical injuries often incur severe morbidity despite relatively small burn size and/or low voltage. When comparing high and low voltage injuries, similarities in endpoints such as neuropsychiatric sequelae, the need for late reconstruction, and failure to return to work challenge previous notions that voltage predicts outcome.

Study of the Performances of a Thermoelectric Generator Based on a Catalytic Meso-Scale H₂/C₃H₈ Fueled Combustor.

PubMed

Abedi, Hossein; Merotto, Laura; Fanciulli, Carlo; Donde, Roberto; De Luliis, Silvana; Passaretti, Francesca

2017-03-01

In this work the thermoelectric generator (TEG) based on catalytic combustion already developed in our lab has been further investigated and improved. The system made of two thermoelectric (TE) modules coupled with a catalytic combustor has been used in this work to obtain higher overall efficiency by adding hydrogen to the fuel mixture. Since implementation of hydrogen as a fuel has shown low and stable combustion temperature in literature, it is expected to achieve good overall efficiency of TEG. Moreover, hydrogen can be used to improve the system inducing self-ignition. Focus of the present work is the implementation of different mixture proportions, varying the amount of hydrogen, and the investigation of their effects on the overall efficiency. The overall TEG efficiency, has been evaluated by parallel characterization of thermoelectric modules and exhaust gases composition. The system performances have been characterized using different mixtures: the results indicate that addition of H₂ to the fuel contribute to increase the chemical and overall TEG efficiency respect to previous work, producing up to 5.92 W of electrical power. Finally, the effects of H₂ for on self-ignition conditions have been investigated finding the minimum H₂ amount for different gas flow rates.

Developing Benchmarks for Solar Radio Bursts

NASA Astrophysics Data System (ADS)

Biesecker, D. A.; White, S. M.; Gopalswamy, N.; Black, C.; Domm, P.; Love, J. J.; Pierson, J.

2016-12-01

Solar radio bursts can interfere with radar, communication, and tracking signals. In severe cases, radio bursts can inhibit the successful use of radio communications and disrupt a wide range of systems that are reliant on Position, Navigation, and Timing services on timescales ranging from minutes to hours across wide areas on the dayside of Earth. The White House's Space Weather Action Plan has asked for solar radio burst intensity benchmarks for an event occurrence frequency of 1 in 100 years and also a theoretical maximum intensity benchmark. The solar radio benchmark team was also asked to define the wavelength/frequency bands of interest. The benchmark team developed preliminary (phase 1) benchmarks for the VHF (30-300 MHz), UHF (300-3000 MHz), GPS (1176-1602 MHz), F10.7 (2800 MHz), and Microwave (4000-20000) bands. The preliminary benchmarks were derived based on previously published work. Limitations in the published work will be addressed in phase 2 of the benchmark process. In addition, deriving theoretical maxima requires additional work, where it is even possible to, in order to meet the Action Plan objectives. In this presentation, we will present the phase 1 benchmarks and the basis used to derive them. We will also present the work that needs to be done in order to complete the final, or phase 2 benchmarks.

Monitoring machining conditions by infrared images

NASA Astrophysics Data System (ADS)

Borelli, Joao E.; Gonzaga Trabasso, Luis; Gonzaga, Adilson; Coelho, Reginaldo T.

2001-03-01

During machining process the knowledge of the temperature is the most important factor in tool analysis. It allows to control main factors that influence tool use, life time and waste. The temperature in the contact area between the piece and the tool is resulting from the material removal in cutting operation and it is too difficult to be obtained because the tool and the work piece are in motion. One way to measure the temperature in this situation is detecting the infrared radiation. This work presents a new methodology for diagnosis and monitoring of machining processes with the use of infrared images. The infrared image provides a map in gray tones of the elements in the process: tool, work piece and chips. Each gray tone in the image corresponds to a certain temperature for each one of those materials and the relationship between the gray tones and the temperature is gotten by the previous of infrared camera calibration. The system developed in this work uses an infrared camera, a frame grabber board and a software composed of three modules. The first module makes the image acquisition and processing. The second module makes the feature image extraction and performs the feature vector. Finally, the third module uses fuzzy logic to evaluate the feature vector and supplies the tool state diagnostic as output.

Working memory accuracy for multiple targets is driven by reward expectation and stimulus contrast with different time-courses.

PubMed

Klink, P Christiaan; Jeurissen, Danique; Theeuwes, Jan; Denys, Damiaan; Roelfsema, Pieter R

2017-08-22

The richness of sensory input dictates that the brain must prioritize and select information for further processing and storage in working memory. Stimulus salience and reward expectations influence this prioritization but their relative contributions and underlying mechanisms are poorly understood. Here we investigate how the quality of working memory for multiple stimuli is determined by priority during encoding and later memory phases. Selective attention could, for instance, act as the primary gating mechanism when stimuli are still visible. Alternatively, observers might still be able to shift priorities across memories during maintenance or retrieval. To distinguish between these possibilities, we investigated how and when reward cues determine working memory accuracy and found that they were only effective during memory encoding. Previously learned, but currently non-predictive, color-reward associations had a similar influence, which gradually weakened without reinforcement. Finally, we show that bottom-up salience, manipulated through varying stimulus contrast, influences memory accuracy during encoding with a fundamentally different time-course than top-down reward cues. While reward-based effects required long stimulus presentation, the influence of contrast was strongest with brief presentations. Our results demonstrate how memory resources are distributed over memory targets and implicates selective attention as a main gating mechanism between sensory and memory systems.

Engineering-Scale Demonstration of DuraLith and Ceramicrete Waste Forms

DOE Office of Scientific and Technical Information (OSTI.GOV)

Josephson, Gary B.; Westsik, Joseph H.; Pires, Richard P.

2011-09-23

To support the selection of a waste form for the liquid secondary wastes from the Hanford Waste Immobilization and Treatment Plant, Washington River Protection Solutions (WRPS) has initiated secondary waste form testing on four candidate waste forms. Two of the candidate waste forms have not been developed to scale as the more mature waste forms. This work describes engineering-scale demonstrations conducted on Ceramicrete and DuraLith candidate waste forms. Both candidate waste forms were successfully demonstrated at an engineering scale. A preliminary conceptual design could be prepared for full-scale production of the candidate waste forms. However, both waste forms are stillmore » too immature to support a detailed design. Formulations for each candidate waste form need to be developed so that the material has a longer working time after mixing the liquid and solid constituents together. Formulations optimized based on previous lab studies did not have sufficient working time to support large-scale testing. The engineering-scale testing was successfully completed using modified formulations. Further lab development and parametric studies are needed to optimize formulations with adequate working time and assess the effects of changes in raw materials and process parameters on the final product performance. Studies on effects of mixing intensity on the initial set time of the waste forms are also needed.« less

A Chronic Longitudinal Characterization of Neurobehavioral and Neuropathological Cognitive Impairment in a Mouse Model of Gulf War Agent Exposure

PubMed Central

Zakirova, Zuchra; Crynen, Gogce; Hassan, Samira; Abdullah, Laila; Horne, Lauren; Mathura, Venkatarajan; Crawford, Fiona; Ait-Ghezala, Ghania

2016-01-01

Gulf War Illness (GWI) is a chronic multisymptom illness with a central nervous system component that includes memory impairment as well as neurological and musculoskeletal deficits. Previous studies have shown that in the First Persian Gulf War conflict (1990–1991) exposure to Gulf War (GW) agents, such as pyridostigmine bromide (PB) and permethrin (PER), were key contributors to the etiology of GWI. For this study, we used our previously established mouse model of GW agent exposure (10 days PB+PER) and undertook an extensive lifelong neurobehavioral characterization of the mice from 11 days to 22.5 months post exposure in order to address the persistence and chronicity of effects suffered by the current GWI patient population, 24 years post-exposure. Mice were evaluated using a battery of neurobehavioral testing paradigms, including Open Field Test (OFT), Elevated Plus Maze (EPM), Three Chamber Testing, Radial Arm Water Maze (RAWM), and Barnes Maze (BM) Test. We also carried out neuropathological analyses at 22.5 months post exposure to GW agents after the final behavioral testing. Our results demonstrate that PB+PER exposed mice exhibit neurobehavioral deficits beginning at the 13 months post exposure time point and continuing trends through the 22.5 month post exposure time point. Furthermore, neuropathological changes, including an increase in GFAP staining in the cerebral cortices of exposed mice, were noted 22.5 months post exposure. Thus, the persistent neuroinflammation evident in our model presents a platform with which to identify novel biological pathways, correlating with emergent outcomes that may be amenable to therapeutic targeting. Furthermore, in this work we confirmed our previous findings that GW agent exposure causes neuropathological changes, and have presented novel data which demonstrate increased disinhibition, and lack of social preference in PB+PER exposed mice at 13 months after exposure. We also extended upon our previous work to cover the lifespan of the laboratory mouse using a battery of neurobehavioral techniques. PMID:26793076

Hyperspectral Image Classification using a Self-Organizing Map

NASA Technical Reports Server (NTRS)

Martinez, P.; Gualtieri, J. A.; Aguilar, P. L.; Perez, R. M.; Linaje, M.; Preciado, J. C.; Plaza, A.

2001-01-01

The use of hyperspectral data to determine the abundance of constituents in a certain portion of the Earth's surface relies on the capability of imaging spectrometers to provide a large amount of information at each pixel of a certain scene. Today, hyperspectral imaging sensors are capable of generating unprecedented volumes of radiometric data. The Airborne Visible/Infrared Imaging Spectrometer (AVIRIS), for example, routinely produces image cubes with 224 spectral bands. This undoubtedly opens a wide range of new possibilities, but the analysis of such a massive amount of information is not an easy task. In fact, most of the existing algorithms devoted to analyzing multispectral images are not applicable in the hyperspectral domain, because of the size and high dimensionality of the images. The application of neural networks to perform unsupervised classification of hyperspectral data has been tested by several authors and also by us in some previous work. We have also focused on analyzing the intrinsic capability of neural networks to parallelize the whole hyperspectral unmixing process. The results shown in this work indicate that neural network models are able to find clusters of closely related hyperspectral signatures, and thus can be used as a powerful tool to achieve the desired classification. The present work discusses the possibility of using a Self Organizing neural network to perform unsupervised classification of hyperspectral images. In sections 3 and 4, the topology of the proposed neural network and the training algorithm are respectively described. Section 5 provides the results we have obtained after applying the proposed methodology to real hyperspectral data, described in section 2. Different parameters in the learning stage have been modified in order to obtain a detailed description of their influence on the final results. Finally, in section 6 we provide the conclusions at which we have arrived.

Seasonal Influenza Forecasting in Real Time Using the Incidence Decay With Exponential Adjustment Model

PubMed Central

Nasserie, Tahmina; Tuite, Ashleigh R; Whitmore, Lindsay; Hatchette, Todd; Drews, Steven J; Peci, Adriana; Kwong, Jeffrey C; Friedman, Dara; Garber, Gary; Gubbay, Jonathan

2017-01-01

Abstract Background Seasonal influenza epidemics occur frequently. Rapid characterization of seasonal dynamics and forecasting of epidemic peaks and final sizes could help support real-time decision-making related to vaccination and other control measures. Real-time forecasting remains challenging. Methods We used the previously described “incidence decay with exponential adjustment” (IDEA) model, a 2-parameter phenomenological model, to evaluate the characteristics of the 2015–2016 influenza season in 4 Canadian jurisdictions: the Provinces of Alberta, Nova Scotia and Ontario, and the City of Ottawa. Model fits were updated weekly with receipt of incident virologically confirmed case counts. Best-fit models were used to project seasonal influenza peaks and epidemic final sizes. Results The 2015–2016 influenza season was mild and late-peaking. Parameter estimates generated through fitting were consistent in the 2 largest jurisdictions (Ontario and Alberta) and with pooled data including Nova Scotia counts (R0 approximately 1.4 for all fits). Lower R0 estimates were generated in Nova Scotia and Ottawa. Final size projections that made use of complete time series were accurate to within 6% of true final sizes, but final size was using pre-peak data. Projections of epidemic peaks stabilized before the true epidemic peak, but these were persistently early (~2 weeks) relative to the true peak. Conclusions A simple, 2-parameter influenza model provided reasonably accurate real-time projections of influenza seasonal dynamics in an atypically late, mild influenza season. Challenges are similar to those seen with more complex forecasting methodologies. Future work includes identification of seasonal characteristics associated with variability in model performance. PMID:29497629

Characteristics of University of Auckland medical students intending to work in the regional/rural setting.

PubMed

Pasley, Thomas; Poole, Phillippa

2009-04-03

To assess the level of interest in regional/rural (RR) practice in final year Auckland medical students and to investigate the demographic characteristics and speciality intentions of these students. A questionnaire was distributed to all graduating students from The University of Auckland's School of Medicine (SOM) in 2006 and 2007. Students intending to work in a RR setting had their demographic data and intended specialty compared with students intending to work in the city. There were 186 respondents, with a response rate of 71%. Of this cohort, 58% stated an intention to work in a city, 15% in an RR setting, and 27% were undecided. RR-destined students were more likely to be Maori and less likely to be Asian then their city-destined counterparts. RR students were more likely to have strong interests in general practice than students intending to work in the city. Prior to the introduction of a specific rural selection pathway, Auckland medical students have shown a similar level of interest in RR medicine when compared to previous studies. However the proportion of students interested in RR health is significantly below the current proportion of people living in RR areas. The large proportion of students undecided on career setting at graduation suggests there may be room to increase the proportion further through formative early postgraduate experiences, or other incentives.

Shifts in Audiovisual Processing in Healthy Aging.

PubMed

Baum, Sarah H; Stevenson, Ryan

2017-09-01

The integration of information across sensory modalities into unified percepts is a fundamental sensory process upon which a multitude of cognitive processes are based. We review the body of literature exploring aging-related changes in audiovisual integration published over the last five years. Specifically, we review the impact of changes in temporal processing, the influence of the effectiveness of sensory inputs, the role of working memory, and the newer studies of intra-individual variability during these processes. Work in the last five years on bottom-up influences of sensory perception has garnered significant attention. Temporal processing, a driving factors of multisensory integration, has now been shown to decouple with multisensory integration in aging, despite their co-decline with aging. The impact of stimulus effectiveness also changes with age, where older adults show maximal benefit from multisensory gain at high signal-to-noise ratios. Following sensory decline, high working memory capacities have now been shown to be somewhat of a protective factor against age-related declines in audiovisual speech perception, particularly in noise. Finally, newer research is emerging focusing on the general intra-individual variability observed with aging. Overall, the studies of the past five years have replicated and expanded on previous work that highlights the role of bottom-up sensory changes with aging and their influence on audiovisual integration, as well as the top-down influence of working memory.

MR-Based Assessment of Bone Marrow Fat in Osteoporosis, Diabetes, and Obesity

PubMed Central

Cordes, Christian; Baum, Thomas; Dieckmeyer, Michael; Ruschke, Stefan; Diefenbach, Maximilian N.; Hauner, Hans; Kirschke, Jan S.; Karampinos, Dimitrios C.

2016-01-01

Bone consists of the mineralized component (i.e., cortex and trabeculae) and the non-mineralized component (i.e., bone marrow). Most of the routine clinical bone imaging uses X-ray-based techniques and focuses on the mineralized component. However, bone marrow adiposity has been also shown to have a strong linkage with bone health. Specifically, multiple previous studies have demonstrated a negative association between bone marrow fat fraction (BMFF) and bone mineral density. Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) are ideal imaging techniques for non-invasively investigating the properties of bone marrow fat. In the present work, we first review the most important MRI and MRS methods for assessing properties of bone marrow fat, including methodologies for measuring BMFF and bone marrow fatty acid composition parameters. Previous MRI and MRS studies measuring BMFF and fat unsaturation in the context of osteoporosis are then reviewed. Finally, previous studies investigating the relationship between bone marrow fat, other fat depots, and bone health in patients with obesity and type 2 diabetes are presented. In summary, MRI and MRS are powerful non-invasive techniques for measuring properties of bone marrow fat in osteoporosis, obesity, and type 2 diabetes and can assist in future studies investigating the pathophysiology of bone changes in the above clinical scenarios. PMID:27445977

Exploring the climate of Proxima B with the Met Office Unified Model

NASA Astrophysics Data System (ADS)

Boutle, Ian A.; Mayne, Nathan J.; Drummond, Benjamin; Manners, James; Goyal, Jayesh; Hugo Lambert, F.; Acreman, David M.; Earnshaw, Paul D.

2017-05-01

We present results of simulations of the climate of the newly discovered planet Proxima Centauri B, performed using the Met Office Unified Model (UM). We examine the responses of both an "Earth-like" atmosphere and simplified nitrogen and trace carbon dioxide atmosphere to the radiation likely received by Proxima Centauri B. Additionally, we explore the effects of orbital eccentricity on the planetary conditions using a range of eccentricities guided by the observational constraints. Overall, our results are in agreement with previous studies in suggesting Proxima Centauri B may well have surface temperatures conducive to the presence of liquid water. Moreover, we have expanded the parameter regime over which the planet may support liquid water to higher values of eccentricity (≳0.1) and lower incident fluxes (881.7 W m-2) than previous work. This increased parameter space arises because of the low sensitivity of the planet to changes in stellar flux, a consequence of the stellar spectrum and orbital configuration. However, we also find interesting differences from previous simulations, such as cooler mean surface temperatures for the tidally-locked case. Finally, we have produced high-resolution planetary emission and reflectance spectra, and highlight signatures of gases vital to the evolution of complex life on Earth (oxygen, ozone and carbon dioxide).

Occupational injury and illness recording and reporting requirements--NAICS update and reporting revisions. Final rule.

PubMed

2014-09-18

OSHA is issuing a final rule to update the appendix to its Injury and Illness Recording and Reporting regulation. The appendix contains a list of industries that are partially exempt from requirements to keep records of work-related injuries and illnesses due to relatively low occupational injury and illness rates. The updated appendix is based on more recent injury and illness data and lists industry groups classified by the North American Industry Classification System (NAICS). The current appendix lists industries classified by Standard Industrial Classification (SIC). The final rule also revises the requirements for reporting work-related fatality, injury, and illness information to OSHA. The current regulation requires employers to report work-related fatalities and in-patient hospitalizations of three or more employees within eight hours of the event. The final rule retains the requirement for employers to report work-related fatalities to OSHA within eight hours of the event but amends the regulation to require employers to report all work-related in-patient hospitalizations, as well as amputations and losses of an eye, to OSHA within 24 hours of the event.

An analysis of stress, burnout, and work commitment among disability support staff in the UK.

PubMed

Smyth, Emmett; Healy, Olive; Lydon, Sinėad

2015-12-01

Previous research has suggested that challenging behaviour emitted by persons with intellectual and developmental disabilities negatively impacts upon the levels of stress and burnout of those who support and care for them. In the current study a sample of disability support workers in the UK (N=138) reported their levels of perceived stress, burnout, and commitment to their work. The relationship between the frequency and severity of aggressive/destructive behaviours to which they were exposed, and these three measures were examined. Results showed that participants scored lower on measures of burnout in the current study than has been reported by similar research studies in the UK and North America. The results revealed an association between challenging behaviours experienced and participants' perceived stress and emotional exhaustion. Perceived stress and burnout were also associated with participants' commitment to their work. Finally, a series of regression analyses identified a number of predictors of emotional exhaustion, depersonalization, and personal accomplishment among disability support workers. The results and their implications for the consideration of disability support worker wellbeing and future research in this area are discussed. Copyright © 2015 Elsevier Ltd. All rights reserved.

Video as a technology for interpersonal communications: a new perspective

NASA Astrophysics Data System (ADS)

Whittaker, Steve

1995-03-01

Some of the most challenging multimedia applications have involved real- time conferencing, using audio and video to support interpersonal communication. Here we re-examine assumptions about the role, importance and implementation of video information in such systems. Rather than focussing on novel technologies, we present evaluation data relevant to both the classes of real-time multimedia applications we should develop and their design and implementation. Evaluations of videoconferencing systems show that previous work has overestimated the importance of video at the expense of audio. This has strong implications for the implementation of bandwidth allocation and synchronization. Furthermore our recent studies of workplace interaction show that prior work has neglected another potentially vital function of visual information: in assessing the communication availability of others. In this new class of application, rather than providing a supplement to audio information, visual information is used to promote the opportunistic communications that are prevalent in face-to-face settings. We discuss early experiments with such connection applications and identify outstanding design and implementation issues. Finally we examine a different class of application 'video-as-data', where the video image is used to transmit information about the work objects themselves, rather than information about interactants.

Trifocal Tensor-Based Adaptive Visual Trajectory Tracking Control of Mobile Robots.

PubMed

Chen, Jian; Jia, Bingxi; Zhang, Kaixiang

2017-11-01

In this paper, a trifocal tensor-based approach is proposed for the visual trajectory tracking task of a nonholonomic mobile robot equipped with a roughly installed monocular camera. The desired trajectory is expressed by a set of prerecorded images, and the robot is regulated to track the desired trajectory using visual feedback. Trifocal tensor is exploited to obtain the orientation and scaled position information used in the control system, and it works for general scenes owing to the generality of trifocal tensor. In the previous works, the start, current, and final images are required to share enough visual information to estimate the trifocal tensor. However, this requirement can be easily violated for perspective cameras with limited field of view. In this paper, key frame strategy is proposed to loosen this requirement, extending the workspace of the visual servo system. Considering the unknown depth and extrinsic parameters (installing position of the camera), an adaptive controller is developed based on Lyapunov methods. The proposed control strategy works for almost all practical circumstances, including both trajectory tracking and pose regulation tasks. Simulations are made based on the virtual experimentation platform (V-REP) to evaluate the effectiveness of the proposed approach.

On the effect of velocity gradients on the depth of correlation in μPIV

NASA Astrophysics Data System (ADS)

Mustin, B.; Stoeber, B.

2016-03-01

The present work revisits the effect of velocity gradients on the depth of the measurement volume (depth of correlation) in microscopic particle image velocimetry (μPIV). General relations between the μPIV weighting functions and the local correlation function are derived from the original definition of the weighting functions. These relations are used to investigate under which circumstances the weighting functions are related to the curvature of the local correlation function. Furthermore, this work proposes a modified definition of the depth of correlation that leads to more realistic results than previous definitions for the case when flow gradients are taken into account. Dimensionless parameters suitable to describe the effect of velocity gradients on μPIV cross correlation are derived and visual interpretations of these parameters are proposed. We then investigate the effect of the dimensionless parameters on the weighting functions and the depth of correlation for different flow fields with spatially constant flow gradients and with spatially varying gradients. Finally this work demonstrates that the results and dimensionless parameters are not strictly bound to a certain model for particle image intensity distributions but are also meaningful when other models for particle images are used.

[Attitudes toward disabilities and mental illness in work settings: a review].

PubMed

Mangili, Edoardo; Ponteri, Marco; Buizza, Chiara; Rossi, Giuseppe

2004-01-01

The aim of the present work is to analyse employers' and employees' attitudes towards the job integration of people with mental illness or disability and to highlight the socio-demographic and organizational characteristic that are more significantly associated with such attitudes. We performed PsycINFO, AskERIC and Medline searches for studies published from 1961 to 2002, with key words such as attitudes, stigma, schizophrenia, mental illness, disability, employers, employees, co-workers and supported employment. Our review of the literature showed that the possibility for people with severe mental illness or disability to enter job market is limited by the discriminating attitudes of employers. The socio-demographic and organizational characteristics, which are more significantly associated with employers' more positive attitudes, are: dimension of the company, previous positive contact with people with disability and employers' high educational level. Such information could be useful to identify and, perhaps, select those companies, which can be predicted as more likely to accept people with mental disorders as part of their work force; they could also be used to train job applicants to improve their social skills. Finally such information could be used to plan specific programs to modify attitudes of employees and employers.

A Route to Dirac Liquid Theory: A Fermi Liquid Description for Dirac Materials

NASA Astrophysics Data System (ADS)

Gochan, Matthew; Bedell, Kevin

Since the pioneering work developed by L.V. Landau sixty years ago, Fermi Liquid Theory has seen great success in describing interacting Fermi systems. While much interest has been generated over the study of non-Fermi Liquid systems, Fermi Liquid theory serves as a formidable model for many systems and offers a rich amount of of results and insight. The recent classification of Dirac Materials, and the lack of a unifying theoretical framework for them, has motivated our study. Dirac materials are a versatile class of materials in which an abundance of unique physical phenomena can be observed. Such materials are found in all dimensions, with the shared property that their low-energy fermionic excitations behave as massless Dirac fermions and are therefore governed by the Dirac equation. The most popular Dirac material, graphene, is the focus of this work. We present our Fermi Liquid description of Graphene. We find many interesting results, specifically in the transport and dynamics of the system. Additionally, we expand on previous work regarding the Virial Theorem and its impact on the Fermi Liquid parameters in graphene. Finally, we remark on viscoelasticity of Dirac Materials and other unusual results that are consequences of AdS-CFT.

Anita: a Mayan peasant woman copes.

PubMed

Elmendorf, M

1979-01-01

This is a case history of Anita, Mayan woman aged 38, who lives in the small village of Can Cun in the Yucatan, Mexico. She has had 10 pregnancies and 7 living children. She nearly died with her last birth. She has a good relationship with her children. She worked several jobs and sold illegal alcohol to put her son, Emiliano, through school. She is close with her married daughter, aged 17. She herself was married at 17. Because of previous bad pregnancies Anita would like to have no more children. Her husband, Demetrio was interested in a vasectomy but couldn't believe he would have the strength to work after the operation. He, like many Mayan men, practiced coitus interruptus and rhythm. When Anita finally went to the family planning clinic, under the auspices of the author, she chose oral contraceptives, but she never actually used them. Many Mayan women seldom get a period because they are always lactating. Some women would rather be pregnant then menstruating. The husband opposes schooling for his children because he needs them to help him work their crops of beans and corn. Sending children to school creates hardship because cash is needed for living expenses.

76 FR 77016 - Controlled Substances: Final Adjusted Aggregate Production Quotas for 2011

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-09

... substances previously referenced, expressed in grams of anhydrous acid or base, as follows: Final adjusted...), diphenoxylate, fentanyl, gamma hydroxybutyric acid, hydrocodone, meperidine, methadone, methadone [[Page 77017... 2011 aggregate production quotas for alfentanil, diphenoxylate, gamma hydroxybutyric acid, meperidine...

National Agricultural-Based Lubricants (NABL) Center

DOE Office of Scientific and Technical Information (OSTI.GOV)

Honary, Lou

2013-09-30

This project, while defined as a one year project from September 30, 2012 – September 30, 2013, was a continuation of a number of tasks that were defined in previous years. Those tasks were performed and were finalized in this period. The UNI-NABL Center, which has been in operation in various forms since 1991, has closed its facilities since September 2013 and will be phasing out in June 2014. This report covers the individual tasks that were identified in the previous reports and provides closure to each task in its final stage.

Undersea landslides: Extent and significance in the Pacific Ocean, an update

USGS Publications Warehouse

Lee, H.J.

2005-01-01

Submarine landslides are known to occur disproportionately in a limited number of environments including fjords, deltas, canyons, volcanic islands and the open continental slope. An evaluation of the progress that has been made in understanding Pacific Ocean submarine landslides over the last 15 years shows that mapping technologies have improved greatly, allowing a better interpretation of landslide features. Some features previously identified as landslides are being reinterpreted by some as sediment waves. Previously underappreciated environments for landslides such as deep-sea trenches are being recognized and lava deltas are being found to be landslide prone. Landslides are also being recognized much more commonly as a potential source of tsunamis. Landslides that have produced tsunamis in the past are being mapped and in some cases modeled. The flow characteristics of turbidity currents produced by landslides in canyon heads have recently been monitored and the source of these failures has been identified using repeated multibeam mapping. Finally, some landslide deposits are being dated as part of assessing risk to coastal cities from landslide-tsunamis. European Geosciences Union ?? 2005 Author(s). This work is licensed under a Creative Commons License.

Glass binder development for a glass-bonded sodalite ceramic waste form

DOE Office of Scientific and Technical Information (OSTI.GOV)

Riley, Brian J.; Vienna, John D.; Frank, Steven M.

This paper discusses work to develop Na 2O-B 2O 3-SiO 2 glass binders for immobilizing LiCl-KCl eutectic salt waste in a glass-bonded sodalite waste form following electrochemical reprocessing of used metallic nuclear fuel. In this paper, five new glasses with ~20 mass% Na 2O were designed to generate waste forms with high sodalite. The glasses were then used to produce ceramic waste forms with a surrogate salt waste. The waste forms made using these new glasses were formulated to generate more sodalite than those made with previous baseline glasses for this type of waste. The coefficients of thermal expansion formore » the glass phase in the glass-bonded sodalite waste forms made with the new binder glasses were closer to the sodalite phase in the critical temperature region near and below the glass transition temperature than previous binder glasses used. Finally, these improvements should result in lower probability of cracking in the full-scale monolithic ceramic waste form, leading to better long-term chemical durability.« less

Glass binder development for a glass-bonded sodalite ceramic waste form

DOE PAGES

Riley, Brian J.; Vienna, John D.; Frank, Steven M.; ...

2017-06-01

This paper discusses work to develop Na 2O-B 2O 3-SiO 2 glass binders for immobilizing LiCl-KCl eutectic salt waste in a glass-bonded sodalite waste form following electrochemical reprocessing of used metallic nuclear fuel. In this paper, five new glasses with ~20 mass% Na 2O were designed to generate waste forms with high sodalite. The glasses were then used to produce ceramic waste forms with a surrogate salt waste. The waste forms made using these new glasses were formulated to generate more sodalite than those made with previous baseline glasses for this type of waste. The coefficients of thermal expansion formore » the glass phase in the glass-bonded sodalite waste forms made with the new binder glasses were closer to the sodalite phase in the critical temperature region near and below the glass transition temperature than previous binder glasses used. Finally, these improvements should result in lower probability of cracking in the full-scale monolithic ceramic waste form, leading to better long-term chemical durability.« less

Effect of elevated substrate temperature deposition on the mechanical losses in tantala thin film coatings

NASA Astrophysics Data System (ADS)

Vajente, G.; Birney, R.; Ananyeva, A.; Angelova, S.; Asselin, R.; Baloukas, B.; Bassiri, R.; Billingsley, G.; Fejer, M. M.; Gibson, D.; Godbout, L. J.; Gustafson, E.; Heptonstall, A.; Hough, J.; MacFoy, S.; Markosyan, A.; Martin, I. W.; Martinu, L.; Murray, P. G.; Penn, S.; Roorda, S.; Rowan, S.; Schiettekatte, F.; Shink, R.; Torrie, C.; Vine, D.; Reid, S.; Adhikari, R. X.

2018-04-01

Brownian thermal noise in dielectric multilayer coatings limits the sensitivity of current and future interferometric gravitational wave detectors. In this work we explore the possibility of improving the mechanical losses of tantala, often used as the high refractive index material, by depositing it on a substrate held at elevated temperature. Promising results have been previously obtained with this technique when applied to amorphous silicon. We show that depositing tantala on a hot substrate reduced the mechanical losses of the as-deposited coating, but subsequent thermal treatments had a larger impact, as they reduced the losses to levels previously reported in the literature. We also show that the reduction in mechanical loss correlates with increased medium range order in the atomic structure of the coatings using x-ray diffraction and Raman spectroscopy. Finally, a discussion is included on our results, which shows that the elevated temperature deposition of pure tantala coatings does not appear to reduce mechanical loss in a similar way to that reported in the literature for amorphous silicon; and we suggest possible future research directions.

Walking through doorways causes forgetting: Further explorations.

PubMed

Radvansky, Gabriel A; Krawietz, Sabine A; Tamplin, Andrea K

2011-08-01

Previous research using virtual environments has revealed a location-updating effect in which there is a decline in memory when people move from one location to another. Here we assess whether this effect reflects the influence of the experienced context, in terms of the degree of immersion of a person in an environment, as suggested by some work in spatial cognition, or by a shift in context. In Experiment 1, the degree of immersion was reduced by using smaller displays. In comparison, in Experiment 2 an actual, rather than a virtual, environment was used, to maximize immersion. Location-updating effects were observed under both of these conditions. In Experiment 3, the original encoding context was reinstated by having a person return to the original room in which objects were first encoded. However, inconsistent with an encoding specificity account, memory did not improve by reinstating this context. Finally, we did a further analysis of the results of this and previous experiments to assess the differential influence of foregrounding and retrieval interference. Overall, these data are interpreted in terms of the event horizon model of event cognition and memory.

Global-Mode Analysis of Full-Disk Data from the Michelson Doppler Imager and the Helioseismic and Magnetic Imager

NASA Astrophysics Data System (ADS)

Larson, Timothy P.; Schou, Jesper

2018-02-01

Building upon our previous work, in which we analyzed smoothed and subsampled velocity data from the Michelson Doppler Imager (MDI), we extend our analysis to unsmoothed, full-resolution MDI data. We also present results from the Helioseismic and Magnetic Imager (HMI), in both full resolution and processed to be a proxy for the low-resolution MDI data. We find that the systematic errors that we saw previously, namely peaks in both the high-latitude rotation rate and the normalized residuals of odd a-coefficients, are almost entirely absent in the two full-resolution analyses. Furthermore, we find that both systematic errors seem to depend almost entirely on how the input images are apodized, rather than on resolution or smoothing. Using the full-resolution HMI data, we confirm our previous findings regarding the effect of using asymmetric profiles on mode parameters, and also find that they occasionally result in more stable fits. We also confirm our previous findings regarding discrepancies between 360-day and 72-day analyses. We further investigate a six-month period previously seen in f-mode frequency shifts using the low-resolution datasets, this time accounting for solar-cycle dependence using magnetic-field data. Both HMI and MDI saw prominent six-month signals in the frequency shifts, but we were surprised to discover that the strongest signal at that frequency occurred in the mode coverage for the low-resolution proxy. Finally, a comparison of mode parameters from HMI and MDI shows that the frequencies and a-coefficients agree closely, encouraging the concatenation of the two datasets.

Development and validation of a web-based questionnaire for surveying the health and working conditions of high-performance marine craft populations.

PubMed

de Alwis, Manudul Pahansen; Lo Martire, Riccardo; Äng, Björn O; Garme, Karl

2016-06-20

High-performance marine craft crews are susceptible to various adverse health conditions caused by multiple interactive factors. However, there are limited epidemiological data available for assessment of working conditions at sea. Although questionnaire surveys are widely used for identifying exposures, outcomes and associated risks with high accuracy levels, until now, no validated epidemiological tool exists for surveying occupational health and performance in these populations. To develop and validate a web-based questionnaire for epidemiological assessment of occupational and individual risk exposure pertinent to the musculoskeletal health conditions and performance in high-performance marine craft populations. A questionnaire for investigating the association between work-related exposure, performance and health was initially developed by a consensus panel under four subdomains, viz. demography, lifestyle, work exposure and health and systematically validated by expert raters for content relevance and simplicity in three consecutive stages, each iteratively followed by a consensus panel revision. The item content validity index (I-CVI) was determined as the proportion of experts giving a rating of 3 or 4. The scale content validity index (S-CVI/Ave) was computed by averaging the I-CVIs for the assessment of the questionnaire as a tool. Finally, the questionnaire was pilot tested. The S-CVI/Ave increased from 0.89 to 0.96 for relevance and from 0.76 to 0.94 for simplicity, resulting in 36 items in the final questionnaire. The pilot test confirmed the feasibility of the questionnaire. The present study shows that the web-based questionnaire fulfils previously published validity acceptance criteria and is therefore considered valid and feasible for the empirical surveying of epidemiological aspects among high-performance marine craft crews and similar populations. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Joint Planning and Development Office Work Plan FY10

DTIC Science & Technology

2010-01-01

IPSA ) Division will make refinements to the NextGen Portfolio Analysis. In addition, IPSA will work with the Department of Defense (DoD) to define and...Submitted Interagency Portfolio and Systems Analysis ( IPSA ) DRAFT DoD Portfolio Analysis Criteria BASELINE DoD Portfolio Analysis Criteria DRAFT...WG Work Plan Review Prototype Capability Selected and Defined CHAs Complete Safety Metrics for IPSA Complete FINAL Prototype Report FINAL

An evolutionary method for synthesizing technological planning and architectural advance

NASA Astrophysics Data System (ADS)

Cole, Bjorn Forstrom

In the development of systems with ever-increasing performance and/or decreasing drawbacks, there inevitably comes a point where more progress is available by shifting to a new set of principles of use. This shift marks a change in architecture, such as between the piston-driven propeller and the jet engine. The shift also often involves an abandonment of previous competencies that have been developed with great effort, and so a foreknowledge of these shifts can be advantageous. A further motivation for this work is the consideration of the Micro Autonomous Systems and Technology (MAST) project, which aims to develop very small (<5 cm) robots for a variety of uses. This is primarily a technology research project, and there is no baseline morphology for a robot to be considered. This then motivates an interest in the ability to automatically compose physical architectures from a series of components and quantitatively analyze them for a basic, conceptual analysis. The ability to do this would enable researchers to turn attention to the most promising forms. This work presents a method for using technology forecasts of components that enable future architectural shifts in order to forecast those shifts. The method consists of the use of multidimensional S-curves, genetic algorithms, and a graph-based formulation of architecture that is more flexible than other morphological techniques. Potential genetic operators are explored in depth to draft a final graph-based genetic algorithm. This algorithm is then implemented in a design code called Sindri, which leverages a commercial design tool named Pacelab. The first chapters of this thesis provide context and a philosophical background to the studies and research that was conducted. In particular, the idea that technology progresses in a fundamentally gradual way is developed and supported with previous historical research. The import of this is that the future can to some degree be predicted by the past, provided that the appropriate technological antecedents are accounted for in developing the projection. The third chapter of the thesis compiles a series of observations and philosophical considerations into a series of research questions. Some research questions are then answered with further thought, observation, and reading, leading to conjectures on the problem. The remainder require some form of experimentation, and so are used to formulate hypotheses. Falsifiability conditions are then generated from those hypotheses, and used to get the development of experiments to be performed, in this case on a computer upon various conditions of use of a genetic algorithm. The fourth chapter of the thesis walks through the formulation of a method to attack the problem of strategically choosing an architecture. This method is designed to find the optimum architecture under multiple conditions, which is required for the ability to play the "what if" games typically undertaken in strategic situations. The chapter walks through a graph-based representation of architecture, provides the rationale for choosing a given technology forecasting technique, and lays out the implementation of the optimization algorithm, named Sindri, within a commercial analysis code, Pacelab. The fifth chapter of the thesis then tests the Sindri code. The first test applied is a series of standardized combinatorial spaces, which are meant to be analogous to test problems traditionally posed to optimizers (e.g., Rosenbrock's valley function). The results from this test assess the value of various operators used to transform the architecture graph in the course of conducting a genetic search. Finally, this method is employed on a test case involving the transition of a miniature helicopter from glow engine to battery propulsion, and finally to a design where the battery functions as both structure and power source. The final two chapters develop conclusions based on the body of work conducted within this thesis and issue some prescriptions for future work. The future work primarily concerns improving the continuous optimization processes undertaken within Sindri and in further refining the graph-based structure for physical architectures.

Integrative Lifecourse and Genetic Analysis of Military Working Dogs

DTIC Science & Technology

2013-10-01

Working Dogs 5b. GRANT NUMBER W81XWH-11-2-0226 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Dr. Kun Huang 5d. PROJECT NUMBER 5e. TASK...we submitted final revisions on our IACUC protocol for the collection of biological samples and Lackland veterinary approval was granted ; and...final Lackland AFB oversight approval was granted and those documents were submitted to DoD CDMRP grant administration. Currently, there is one final

The cost of misremembering: Inferring the loss function in visual working memory.

PubMed

Sims, Chris R

2015-03-04

Visual working memory (VWM) is a highly limited storage system. A basic consequence of this fact is that visual memories cannot perfectly encode or represent the veridical structure of the world. However, in natural tasks, some memory errors might be more costly than others. This raises the intriguing possibility that the nature of memory error reflects the costs of committing different kinds of errors. Many existing theories assume that visual memories are noise-corrupted versions of afferent perceptual signals. However, this additive noise assumption oversimplifies the problem. Implicit in the behavioral phenomena of visual working memory is the concept of a loss function: a mathematical entity that describes the relative cost to the organism of making different types of memory errors. An optimally efficient memory system is one that minimizes the expected loss according to a particular loss function, while subject to a constraint on memory capacity. This paper describes a novel theoretical framework for characterizing visual working memory in terms of its implicit loss function. Using inverse decision theory, the empirical loss function is estimated from the results of a standard delayed recall visual memory experiment. These results are compared to the predicted behavior of a visual working memory system that is optimally efficient for a previously identified natural task, gaze correction following saccadic error. Finally, the approach is compared to alternative models of visual working memory, and shown to offer a superior account of the empirical data across a range of experimental datasets. © 2015 ARVO.

Motion control in free-standing shape-memory actuators

NASA Astrophysics Data System (ADS)

Belmonte, Alberto; Lama, Giuseppe C.; Cerruti, Pierfrancesco; Ambrogi, Veronica; Fernández-Francos, Xavier; De la Flor, Silvia

2018-07-01

In this work, free-standing shape-memory thermally triggered actuators are developed by laminating ‘thiol-epoxy’-based glassy thermoset (GT) and stretched liquid-crystalline network (LCN) films. A sequential curing process was used to obtain GTs with tailored thermomechanical properties and network relaxation dynamics, and also to assemble the final actuator. The actuation extent, rate and time were studied by varying the GT and the heating rate in thermo-actuation with an experimental approach. The results demonstrate that it is possible to tailor the actuation rate and time by designing GT materials with a glass transition temperature close to that of the liquid-crystalline-to-isotropic phase transition of the LCN, thus making it possible to couple the two processes. Such coupling is also possible in rapid heating processes even when the glass transition temperature of the GT is clearly lower than the isotropization temperature of the LCN, depending on the network relaxation dynamics of the GT and the presence of thermal gradients within the actuators. Interestingly, varying the GT network relaxation dynamics does not affect the actuation extent. As predicted by the analytical model developed in our previous work, the modulus of the GT layer is mainly responsible for the actuation extent. Finally, to demonstrate the enhanced control of the actuation, specifically designed actuators were assembled in a three-dimensional actuating device able to make complex motions (including ‘S-type’ bending). This approach makes it possible to engineer advanced functional materials for application in self-adaptable structures and soft robotics.

Photoionization of water molecules by a train of attosecond pulses assisted by a near-infrared laser: delay and polarization control

NASA Astrophysics Data System (ADS)

Martini, Lara; Boll, Diego I. R.; Fojón, Omar A.

2017-08-01

Basic reactions involving water molecules are essential to understand the interaction between radiation and the biological tissue because living cells are composed mostly by water. Therefore, the knowledge of ionization of the latter is crucial in many domains of Biology and Physics. So, we study theoretically the photoionization of water molecules by extreme ultraviolet attopulse trains assisted by lasers in the near-infrared range. We use a separable Coulomb-Volkov model in which the temporal evolution of the system can be divided into three stages allowing spatial and temporal separation for the Coulomb and Volkov final state wavefunctions. First, we analyze photoelectron angular distributions for different delays between the attopulse train and the assistant laser field. We compare our results for water and Ne atoms as they belong to the same isoelectronic series. Moreover, we contrast our calculations with previous theoretical and experimental work for Ar atoms due to the similarities of the orbitals involved in the reaction. Second, we study the effect of varying the relative orientations of the attopulse and laser field polarizations and we compare our predictions with other theories and experiments. We expect these studies contribute to the improvement of polarization experiments and the development of the attopulse trains and assistant laser fields technologies. Finally, we hope our work promote progress on the control of the chemical reactivity of water molecules since this could be useful in different fields such as radiobiology and medical physics.

NASA advanced design program. Design and analysis of a radio-controlled flying wing aircraft

NASA Technical Reports Server (NTRS)

1993-01-01

The main challenge of this project was to design an aircraft that will achieve stability while flying without a horizontal tail. The project focused on both the design, analysis and construction of a remotely piloted, elliptical shaped flying wing. The design team was composed of four sub-groups each of which dealt with the different aspects of the design, namely aerodynamics, stability and control, propulsion, and structures. Each member of the team initially researched the background information pertaining to specific facets of the project. Since previous work on this topic was limited, most of the focus of the project was directed towards developing an understanding of the natural instability of the aircraft. Once the design team entered the conceptual stage of the project, a series of compromises had to be made to satisfy the unique requirements of each sub-group. As a result of the numerous calculations and iterations necessary, computers were utilized extensively. In order to visualize the design and layout of the wing, engines and control surfaces, a solid modeling package was used to evaluate optimum design placements. When the design was finalized, construction began with the help of all the members of the project team. The nature of the carbon composite construction process demanded long hours of manual labor. The assembly of the engine systems also required precision hand work. The final product of this project is the Elang, a one-of-a-kind remotely piloted aircraft of composite construction powered by two ducted fan engines.

Longitudinal study of veterinary students and veterinarians: family and gender issues after 20 years.

PubMed

Heath, T J

2007-07-01

To examine and compare some family issues and work experiences of males and females who graduated as veterinarians 15 years ago. Questionnaires were completed by 134 of 137 veterinarians who graduated 15 years ago, and who had been surveyed in their first and final years as students, and 1, 5, 10 and 15 years after they graduated. Comparisons were made with official statistics, information from earlier surveys in this longitudinal study, and data from a previously published national study. By 15 years after they graduated, 82% had been married or in a comparable long-term relationship, and 23% of these were to another veterinarian. Thirteen percent of those who had been married were now separated or divorced, and 50% of them had remarried, a similar proportion to official statistics for Australians of comparable age. Approximately 20% of both males and females were doing no veterinary work, but more males (68%) than females (37%) were doing veterinary work full time. Most who were doing veterinary work were in private practice, and of these, small animals represented 76% of the work of the males and 88% of the work of the females. Females in private practice were more likely to be employees, especially if working part time, but those working full time were just as likely as males to be practice owners. In general males earned more than females. By 15 years after graduation, the percentages of males and females doing some veterinary work are similar, although males are more likely than females to be working full time. Females and males in full time private practice are equally likely to be practice owners, but female owners and female employees earn less than comparable males. Males and females have similar attitudes to having done the veterinary course.

40 CFR 35.910-5 - Additional allotments of previously withheld sums.

Code of Federal Regulations, 2010 CFR

2010-07-01

... ($11 billion) and subtracting the previously allotted sums, formerly set forth in § 35.910-3(c). (c... Pub. L. 93-243; and, finally, by subtracting the previously allotted sums set forth in § 35.910-4(c). (d) Based upon the computations set forth in paragraphs (b) and (c) of this section, the total...

Knee cartilage extraction and bone-cartilage interface analysis from 3D MRI data sets

NASA Astrophysics Data System (ADS)

Tamez-Pena, Jose G.; Barbu-McInnis, Monica; Totterman, Saara

2004-05-01

This works presents a robust methodology for the analysis of the knee joint cartilage and the knee bone-cartilage interface from fused MRI sets. The proposed approach starts by fusing a set of two 3D MR images the knee. Although the proposed method is not pulse sequence dependent, the first sequence should be programmed to achieve good contrast between bone and cartilage. The recommended second pulse sequence is one that maximizes the contrast between cartilage and surrounding soft tissues. Once both pulse sequences are fused, the proposed bone-cartilage analysis is done in four major steps. First, an unsupervised segmentation algorithm is used to extract the femur, the tibia, and the patella. Second, a knowledge based feature extraction algorithm is used to extract the femoral, tibia and patellar cartilages. Third, a trained user corrects cartilage miss-classifications done by the automated extracted cartilage. Finally, the final segmentation is the revisited using an unsupervised MAP voxel relaxation algorithm. This final segmentation has the property that includes the extracted bone tissue as well as all the cartilage tissue. This is an improvement over previous approaches where only the cartilage was segmented. Furthermore, this approach yields very reproducible segmentation results in a set of scan-rescan experiments. When these segmentations were coupled with a partial volume compensated surface extraction algorithm the volume, area, thickness measurements shows precisions around 2.6%

The vibroacoustic response and sound absorption performance of multilayer, microperforated rib-stiffened plates

NASA Astrophysics Data System (ADS)

Zhou, Haian; Wang, Xiaoming; Wu, Huayong; Meng, Jianbing

2017-10-01

The vibroacoustic response and sound absorption performance of a structure composed of multilayer plates and one rigid back wall are theoretically analyzed. In this structure, all plates are two-dimensional, microperforated, and periodically rib-stiffened. To investigate such a structural system, semianalytical models of one-layer and multilayer plate structures considering the vibration effects are first developed. Then approaches of the space harmonic method and Fourier transforms are applied to a one-layer plate, and finally the cascade connection method is utilized for a multilayer plate structure. Based on fundamental acoustic formulas, the vibroacoustic responses of microperforated stiffened plates are expressed as functions of a series of harmonic amplitudes of plate displacement, which are then solved by employing the numerical truncation method. Applying the inverse Fourier transform, wave propagation, and linear addition properties, the equations of the sound pressures and absorption coefficients for the one-layer and multilayer stiffened plates in physical space are finally derived. Using numerical examples, the effects of the most important physical parameters—for example, the perforation ratio of the plate, sound incident angles, and periodical rib spacing—on sound absorption performance are examined. Numerical results indicate that the sound absorption performance of the studied structure is effectively enhanced by the flexural vibration of the plate in water. Finally, the proposed approaches are validated by comparing the results of stiffened plates of the present work with solutions from previous studies.

A study of some fundamental physicochemical variables on the morphology of mesoporous silica nanoparticles MCM-41 type

NASA Astrophysics Data System (ADS)

Beltrán-Osuna, Ángela A.; Gómez Ribelles, José L.; Perilla, Jairo E.

2017-12-01

All variables affecting the morphology of mesoporous silica nanoparticles (MSN) should be carefully analyzed in order to truly tailored design their mesoporous structure according to their final use. Although complete control on MCM-41 synthesis has been already claimed, reproducibility and repeatability of results remain a big issue due to the lack of information reported in literature. Stirring rate, reaction volume, and system configuration (i.e., opened or closed reactor) are three variables that are usually omitted, making the comparison of product characteristics difficult. Specifically, the rate of solvent evaporation is seldom disclosed, and its influence has not been previously analyzed. These variables were systematically studied in this work, and they were proven to have a fundamental impact on final particle morphology. Hence, a high degree of circularity ( C = 0.97) and monodispersed particle size distributions were only achieved when a stirring speed of 500 rpm and a reaction scale of 500 mL were used in a partially opened system, for a 2 h reaction at 80 °C. Well-shaped spherical mesoporous silica nanoparticles with a diameter of 95 nm, a pore size of 2.8 nm, and a total surface area of 954 m2 g-1 were obtained. Final characteristics made this product suitable to be used in biomedicine and nanopharmaceutics, especially for the design of drug delivery systems.

20 CFR 295.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... court order of such country. Court decree means a final decree of divorce, dissolution, annulment, or... previously issued decree of divorce, dissolution, annulment, or legal separation), which is issued in... to the employee and that marriage has ended by final decree of divorce, dissolution, or annulment...

20 CFR 295.2 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... court order of such country. Court decree means a final decree of divorce, dissolution, annulment, or... previously issued decree of divorce, dissolution, annulment, or legal separation), which is issued in... to the employee and that marriage has ended by final decree of divorce, dissolution, or annulment...

20 CFR 295.2 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-04-01

... court order of such country. Court decree means a final decree of divorce, dissolution, annulment, or... previously issued decree of divorce, dissolution, annulment, or legal separation), which is issued in... to the employee and that marriage has ended by final decree of divorce, dissolution, or annulment...

20 CFR 295.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-04-01

... court order of such country. Court decree means a final decree of divorce, dissolution, annulment, or... previously issued decree of divorce, dissolution, annulment, or legal separation), which is issued in... to the employee and that marriage has ended by final decree of divorce, dissolution, or annulment...

20 CFR 295.2 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-04-01

... court order of such country. Court decree means a final decree of divorce, dissolution, annulment, or... previously issued decree of divorce, dissolution, annulment, or legal separation), which is issued in... to the employee and that marriage has ended by final decree of divorce, dissolution, or annulment...

Phrase-Final Words in Greek Storytelling Speech: A Study on the Effect of a Culturally-Specific Prosodic Feature on Short-Term Memory.

PubMed

Loutrari, Ariadne; Tselekidou, Freideriki; Proios, Hariklia

2018-02-27

Prosodic patterns of speech appear to make a critical contribution to memory-related processing. We considered the case of a previously unexplored prosodic feature of Greek storytelling and its effect on free recall in thirty typically developing children between the ages of 10 and 12 years, using short ecologically valid auditory stimuli. The combination of a falling pitch contour and, more notably, extensive final-syllable vowel lengthening, which gives rise to the prosodic feature in question, led to statistically significantly higher performance in comparison to neutral phrase-final prosody. Number of syllables in target words did not reveal substantial difference in performance. The current study presents a previously undocumented culturally-specific prosodic pattern and its effect on short-term memory.

36 CFR 212.1 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... materials investigations, surveys, and tests; (6) Preliminary and final designs; (7) Preliminary and final... surveys to establish line and grade for the work, to control the work, and to measure quantities; (2... battery-powered, that is designed solely for use by a mobility-impaired person for locomotion, and that is...

36 CFR 212.1 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... materials investigations, surveys, and tests; (6) Preliminary and final designs; (7) Preliminary and final... surveys to establish line and grade for the work, to control the work, and to measure quantities; (2... battery-powered, that is designed solely for use by a mobility-impaired person for locomotion, and that is...

36 CFR 212.1 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... materials investigations, surveys, and tests; (6) Preliminary and final designs; (7) Preliminary and final... surveys to establish line and grade for the work, to control the work, and to measure quantities; (2... battery-powered, that is designed solely for use by a mobility-impaired person for locomotion, and that is...

Recommendation of LightSquared Subsidiary LLC : [the working group] final report

DOT National Transportation Integrated Search

2011-01-01

This is the final report of the Working Group (WG) that was formed to study the GPS overload/desensitization issue as described by the Federal Communications Commission (FCC) in DA 11-133. On February 25, 2011, LightSquared and the United States Glob...

20 CFR 411.630 - Is SSA's decision final?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Is SSA's decision final? 411.630 Section 411.630 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Ticket to Work Program Dispute Resolution Disputes Between Beneficiaries and Employment Networks § 411...

20 CFR 411.630 - Is SSA's decision final?

Code of Federal Regulations, 2012 CFR

2012-04-01

... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Is SSA's decision final? 411.630 Section 411.630 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Ticket to Work Program Dispute Resolution Disputes Between Beneficiaries and Employment Networks § 411...

20 CFR 411.630 - Is SSA's decision final?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Is SSA's decision final? 411.630 Section 411.630 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Ticket to Work Program Dispute Resolution Disputes Between Beneficiaries and Employment Networks § 411...

20 CFR 411.630 - Is SSA's decision final?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Is SSA's decision final? 411.630 Section 411.630 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Ticket to Work Program Dispute Resolution Disputes Between Beneficiaries and Employment Networks § 411...

20 CFR 411.630 - Is SSA's decision final?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Is SSA's decision final? 411.630 Section 411.630 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Ticket to Work Program Dispute Resolution Disputes Between Beneficiaries and Employment Networks § 411...

Cauchy horizon stability in a collapsing spherical dust cloud: II. Energy bounds for test fields and odd-parity gravitational perturbations

NASA Astrophysics Data System (ADS)

Ortiz, Néstor; Sarbach, Olivier

2018-01-01

We analyze the stability of the Cauchy horizon associated with a globally naked, shell-focussing singularity arising from the complete gravitational collapse of a spherical dust cloud. In a previous work, we have studied the dynamics of spherical test scalar fields on such a background. In particular, we proved that such fields cannot develop any divergences which propagate along the Cauchy horizon. In the present work, we extend our analysis to the more general case of test fields without symmetries and to linearized gravitational perturbations with odd parity. To this purpose, we first consider test fields possessing a divergence-free stress-energy tensor satisfying the dominant energy condition, and we prove that a suitable energy norm is uniformly bounded in the domain of dependence of the initial slice. In particular, this result implies that free-falling observers co-moving with the dust particles measure a finite energy of the field, even as they cross the Cauchy horizon at points lying arbitrarily close to the central singularity. Next, for the case of Klein–Gordon fields, we derive point-wise bounds from our energy estimates which imply that the scalar field cannot diverge at the Cauchy horizon, except possibly at the central singular point. Finally, we analyze the behaviour of odd-parity, linear gravitational and dust perturbations of the collapsing spacetime. Similarly to the scalar field case, we prove that the relevant gauge-invariant combinations of the metric perturbations stay bounded away from the central singularity, implying that no divergences can propagate in the vacuum region. Our results are in accordance with previous numerical studies and analytic work in the self-similar case.

The Cation−π Interaction Enables a Halo-Tag Fluorogenic Probe for Fast No-Wash Live Cell Imaging and Gel-Free Protein Quantification

PubMed Central

2017-01-01

The design of fluorogenic probes for a Halo tag is highly desirable but challenging. Previous work achieved this goal by controlling the chemical switch of spirolactones upon the covalent conjugation between the Halo tag and probes or by incorporating a “channel dye” into the substrate binding tunnel of the Halo tag. In this work, we have developed a novel class of Halo-tag fluorogenic probes that are derived from solvatochromic fluorophores. The optimal probe, harboring a benzothiadiazole scaffold, exhibits a 1000-fold fluorescence enhancement upon reaction with the Halo tag. Structural, computational, and biochemical studies reveal that the benzene ring of a tryptophan residue engages in a cation−π interaction with the dimethylamino electron-donating group of the benzothiadiazole fluorophore in its excited state. We further demonstrate using noncanonical fluorinated tryptophan that the cation−π interaction directly contributes to the fluorogenicity of the benzothiadiazole fluorophore. Mechanistically, this interaction could contribute to the fluorogenicity by promoting the excited-state charge separation and inhibiting the twisting motion of the dimethylamino group, both leading to an enhanced fluorogenicity. Finally, we demonstrate the utility of the probe in no-wash direct imaging of Halo-tagged proteins in live cells. In addition, the fluorogenic nature of the probe enables a gel-free quantification of fusion proteins expressed in mammalian cells, an application that was not possible with previously nonfluorogenic Halo-tag probes. The unique mechanism revealed by this work suggests that incorporation of an excited-state cation−π interaction could be a feasible strategy for enhancing the optical performance of fluorophores and fluorogenic sensors. PMID:28221782

The Cation-π Interaction Enables a Halo-Tag Fluorogenic Probe for Fast No-Wash Live Cell Imaging and Gel-Free Protein Quantification.

PubMed

Liu, Yu; Miao, Kun; Dunham, Noah P; Liu, Hongbin; Fares, Matthew; Boal, Amie K; Li, Xiaosong; Zhang, Xin

2017-03-21

The design of fluorogenic probes for a Halo tag is highly desirable but challenging. Previous work achieved this goal by controlling the chemical switch of spirolactones upon the covalent conjugation between the Halo tag and probes or by incorporating a "channel dye" into the substrate binding tunnel of the Halo tag. In this work, we have developed a novel class of Halo-tag fluorogenic probes that are derived from solvatochromic fluorophores. The optimal probe, harboring a benzothiadiazole scaffold, exhibits a 1000-fold fluorescence enhancement upon reaction with the Halo tag. Structural, computational, and biochemical studies reveal that the benzene ring of a tryptophan residue engages in a cation-π interaction with the dimethylamino electron-donating group of the benzothiadiazole fluorophore in its excited state. We further demonstrate using noncanonical fluorinated tryptophan that the cation-π interaction directly contributes to the fluorogenicity of the benzothiadiazole fluorophore. Mechanistically, this interaction could contribute to the fluorogenicity by promoting the excited-state charge separation and inhibiting the twisting motion of the dimethylamino group, both leading to an enhanced fluorogenicity. Finally, we demonstrate the utility of the probe in no-wash direct imaging of Halo-tagged proteins in live cells. In addition, the fluorogenic nature of the probe enables a gel-free quantification of fusion proteins expressed in mammalian cells, an application that was not possible with previously nonfluorogenic Halo-tag probes. The unique mechanism revealed by this work suggests that incorporation of an excited-state cation-π interaction could be a feasible strategy for enhancing the optical performance of fluorophores and fluorogenic sensors.

A Quantitative Prioritisation of Human and Domestic Animal Pathogens in Europe

PubMed Central

McIntyre, K. Marie; Setzkorn, Christian; Hepworth, Philip J.; Morand, Serge; Morse, Andrew P.; Baylis, Matthew

2014-01-01

Disease or pathogen risk prioritisations aid understanding of infectious agent impact within surveillance or mitigation and biosecurity work, but take significant development. Previous work has shown the H-(Hirsch-)index as an alternative proxy. We present a weighted risk analysis describing infectious pathogen impact for human health (human pathogens) and well-being (domestic animal pathogens) using an objective, evidence-based, repeatable approach; the H-index. This study established the highest H-index European pathogens. Commonalities amongst pathogens not included in previous surveillance or risk analyses were examined. Differences between host types (humans/animals/zoonotic) in pathogen H-indices were explored as a One Health impact indicator. Finally, the acceptability of the H-index proxy for animal pathogen impact was examined by comparison with other measures. 57 pathogens appeared solely in the top 100 highest H-indices (1) human or (2) animal pathogens list, and 43 occurred in both. Of human pathogens, 66 were zoonotic and 67 were emerging, compared to 67 and 57 for animals. There were statistically significant differences between H-indices for host types (humans, animal, zoonotic), and there was limited evidence that H-indices are a reasonable proxy for animal pathogen impact. This work addresses measures outlined by the European Commission to strengthen climate change resilience and biosecurity for infectious diseases. The results include a quantitative evaluation of infectious pathogen impact, and suggest greater impacts of human-only compared to zoonotic pathogens or scientific under-representation of zoonoses. The outputs separate high and low impact pathogens, and should be combined with other risk assessment methods relying on expert opinion or qualitative data for priority setting, or could be used to prioritise diseases for which formal risk assessments are not possible because of data gaps. PMID:25136810

Embedded-Based Graphics Processing Unit Cluster Platform for Multiple Sequence Alignments

PubMed Central

Wei, Jyh-Da; Cheng, Hui-Jun; Lin, Chun-Yuan; Ye, Jin; Yeh, Kuan-Yu

2017-01-01

High-end graphics processing units (GPUs), such as NVIDIA Tesla/Fermi/Kepler series cards with thousands of cores per chip, are widely applied to high-performance computing fields in a decade. These desktop GPU cards should be installed in personal computers/servers with desktop CPUs, and the cost and power consumption of constructing a GPU cluster platform are very high. In recent years, NVIDIA releases an embedded board, called Jetson Tegra K1 (TK1), which contains 4 ARM Cortex-A15 CPUs and 192 Compute Unified Device Architecture cores (belong to Kepler GPUs). Jetson Tegra K1 has several advantages, such as the low cost, low power consumption, and high applicability, and it has been applied into several specific applications. In our previous work, a bioinformatics platform with a single TK1 (STK platform) was constructed, and this previous work is also used to prove that the Web and mobile services can be implemented in the STK platform with a good cost-performance ratio by comparing a STK platform with the desktop CPU and GPU. In this work, an embedded-based GPU cluster platform will be constructed with multiple TK1s (MTK platform). Complex system installation and setup are necessary procedures at first. Then, 2 job assignment modes are designed for the MTK platform to provide services for users. Finally, ClustalW v2.0.11 and ClustalWtk will be ported to the MTK platform. The experimental results showed that the speedup ratios achieved 5.5 and 4.8 times for ClustalW v2.0.11 and ClustalWtk, respectively, by comparing 6 TK1s with a single TK1. The MTK platform is proven to be useful for multiple sequence alignments. PMID:28835734

Engineered Respiro-Fermentative Metabolism for the Production of Biofuels and Biochemicals from Fatty Acid-Rich Feedstocks▿ †

PubMed Central

Dellomonaco, Clementina; Rivera, Carlos; Campbell, Paul; Gonzalez, Ramon

2010-01-01

Although lignocellulosic sugars have been proposed as the primary feedstock for the biological production of renewable fuels and chemicals, the availability of fatty acid (FA)-rich feedstocks and recent progress in the development of oil-accumulating organisms make FAs an attractive alternative. In addition to their abundance, the metabolism of FAs is very efficient and could support product yields significantly higher than those obtained from lignocellulosic sugars. However, FAs are metabolized only under respiratory conditions, a metabolic mode that does not support the synthesis of fermentation products. In the work reported here we engineered several native and heterologous fermentative pathways to function in Escherichia coli under aerobic conditions, thus creating a respiro-fermentative metabolic mode that enables the efficient synthesis of fuels and chemicals from FAs. Representative biofuels (ethanol and butanol) and biochemicals (acetate, acetone, isopropanol, succinate, and propionate) were chosen as target products to illustrate the feasibility of the proposed platform. The yields of ethanol, acetate, and acetone in the engineered strains exceeded those reported in the literature for their production from sugars, and in the cases of ethanol and acetate they also surpassed the maximum theoretical values that can be achieved from lignocellulosic sugars. Butanol was produced at yields and titers that were between 2- and 3-fold higher than those reported for its production from sugars in previously engineered microorganisms. Moreover, our work demonstrates production of propionate, a compound previously thought to be synthesized only by propionibacteria, in E. coli. Finally, the synthesis of isopropanol and succinate was also demonstrated. The work reported here represents the first effort toward engineering microorganisms for the conversion of FAs to the aforementioned products. PMID:20525863

Smoking and (Not) Voting: The Negative Relationship Between a Health-Risk Behavior and Political Participation in Colorado.

PubMed

Albright, Karen; Hood, Nancy; Ma, Ming; Levinson, Arnold H

2016-03-01

Considerable evidence suggests that cigarette smokers are an increasingly marginalized population, involved in fewer organizations and activities and with less interpersonal trust than their nonsmoking counterparts. However, only two previous studies, both among Swedish populations, have investigated smokers' attitudes toward political systems and institutions. The current, cross-sectional study examines smoking in relation to voting, a direct behavioral measure of civic and political engagement that at least partly reflects trust in formal political institutions. Secondary analyses were conducted of interview data from 11 626 respondents in the Colorado Tobacco Attitudes and Behaviors Survey. Data were collected via telephone between October 2005 and mid-April 2006 and included respondents' reported voting behavior in the 2004 national election; the participation rate was 89.7%. Balanced multiple logistic regression was used to examine associations between smoking and voting while controlling for other covariates known to be associated with both variables. In the final model, daily smokers were less than half as likely as nonsmokers to report having voted in the election. The results suggest possible consonance with previous work linking smoking with political mistrust. Possible causal mechanisms are discussed. This study is the first to link a health-risk behavior with electoral participation, and provides initial evidence that smoking is negatively associated with political participation. Future research should investigate how public health might enhance tobacco control efforts by taking nonvoting behavior into consideration, or creatively combining smoking cessation interventions with voter registration and other civic engagement work, particularly among socioeconomically disadvantaged populations. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Embedded-Based Graphics Processing Unit Cluster Platform for Multiple Sequence Alignments.

PubMed

Wei, Jyh-Da; Cheng, Hui-Jun; Lin, Chun-Yuan; Ye, Jin; Yeh, Kuan-Yu

2017-01-01

High-end graphics processing units (GPUs), such as NVIDIA Tesla/Fermi/Kepler series cards with thousands of cores per chip, are widely applied to high-performance computing fields in a decade. These desktop GPU cards should be installed in personal computers/servers with desktop CPUs, and the cost and power consumption of constructing a GPU cluster platform are very high. In recent years, NVIDIA releases an embedded board, called Jetson Tegra K1 (TK1), which contains 4 ARM Cortex-A15 CPUs and 192 Compute Unified Device Architecture cores (belong to Kepler GPUs). Jetson Tegra K1 has several advantages, such as the low cost, low power consumption, and high applicability, and it has been applied into several specific applications. In our previous work, a bioinformatics platform with a single TK1 (STK platform) was constructed, and this previous work is also used to prove that the Web and mobile services can be implemented in the STK platform with a good cost-performance ratio by comparing a STK platform with the desktop CPU and GPU. In this work, an embedded-based GPU cluster platform will be constructed with multiple TK1s (MTK platform). Complex system installation and setup are necessary procedures at first. Then, 2 job assignment modes are designed for the MTK platform to provide services for users. Finally, ClustalW v2.0.11 and ClustalWtk will be ported to the MTK platform. The experimental results showed that the speedup ratios achieved 5.5 and 4.8 times for ClustalW v2.0.11 and ClustalWtk, respectively, by comparing 6 TK1s with a single TK1. The MTK platform is proven to be useful for multiple sequence alignments.

Improving Spherical Photogrammetry Using 360° OMNI-CAMERAS: Use Cases and New Applications

NASA Astrophysics Data System (ADS)

Fangi, G.; Pierdicca, R.; Sturari, M.; Malinverni, E. S.

2018-05-01

During the last few years, there has been a growing exploitation of consumer-grade cameras allowing one to capture 360° images. Each device has different features and the choice should be entrusted on the use and the expected final output. The interest on such technology within the research community is related to its use versatility, enabling the user to capture the world with an omnidirectional view with just one shot. The potential is huge and the literature presents many use cases in several research domains, spanning from retail to construction, from tourism to immersive virtual reality solutions. However, the domain that could the most benefit is Cultural Heritage (CH), since these sensors are particularly suitable for documenting a real scene with architectural detail. Following the previous researches conducted by Fangi, which introduced its own methodology called Spherical Photogrammetry (SP), the aim of this paper is to present some tests conducted with the omni-camera Panono 360° which reach a final resolution comparable with a traditional camera and to validate, after almost ten years from the first experiment, its reliability for architectural surveying purposes. Tests have been conducted choosing as study cases Santa Maria della Piazza and San Francesco alle scale Churches in Ancona, Italy, since they were previously surveyed and documented with SP methodology. In this way, it has been possible to validate the accuracy of the new survey, performed by means an omni-camera, compared with the previous one for both outdoor and indoor scenario. The core idea behind this work is to validate if this new sensor can replace the standard image collection phase, speeding up the process, assuring at the same time the final accuracy of the survey. The experiment conducted demonstrate that, w.r.t. the SP methodology developed so far, the main advantage in using 360° omni-directional cameras lies on increasing the rapidity of acquisition and panorama creation phases. Moreover, in order to foresee the implications that a wide adoption of fast and agile tools of acquisition could bring within the CH domain, points cloud have been generated with the same panoramas and visualized in a WEB application, to allow a result dissemination between the users.

Degradation pathway of the naphthalene azo dye intermediate 1-diazo-2- naphthol-4-sulfonic acid using Fenton's reagent.

PubMed

Zhu, Nanwen; Gu, Lin; Yuan, Haiping; Lou, Ziyang; Wang, Liang; Zhang, Xin

2012-08-01

Degradation of naphthalene dye intermediate 1-diazo-2- naphthol-4-sulfonic acid (1,2,4-Acid) by Fenton process has been studied in depth for the purpose of learning more about the reactions involved in the oxidation of 1,2,4-Acid. During 1,2,4-Acid oxidation, the solution color initially takes on a dark red, then to dark black associated with the formation of quinodial-type structures, and then goes to dark brown and gradually disappears, indicating a fast degradation of azo group. The observed color changes of the solution are a result of main reaction intermediates, which can be an indicator of the level of oxidization reached. Nevertheless, complete TOC removal is not accomplished, in accordance with the presence of resistant carboxylic acids at the end of the reaction. The intermediates generated along the reaction time have been identified and quantified. UPLC-(ESI)-TOF-HRMS analysis allows the detection of 19 aromatic compounds of different size and complexity. Some of them share the same accurate mass but appear at different retention time, evidencing their different molecular structures. Heteroatom oxidation products like SO(4)(2-) have also been quantified and explanations of their release are proposed. Short-chain carboxylic acids are detected at long reaction time, as a previous step to complete the process of dye mineralization. Finally, considering all the findings of the present study and previous related works, the evolution from the original 1,2,4-Acid to the final products is proposed in a general reaction scheme. Copyright © 2012 Elsevier Ltd. All rights reserved.

Wide binaries in Tycho-Gaia II: metallicities, abundances and prospects for chemical tagging

NASA Astrophysics Data System (ADS)

Andrews, Jeff J.; Chanamé, Julio; Agüeros, Marcel A.

2018-02-01

From our recent catalogue based on the first Gaia data release (TGAS), we select wide binaries in which both stars have been observed by the Radial Velocity Experiment (RAVE) or the Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST). Using RAVE and LAMOST metallicities and RAVE Mg, Al, Si, Ti and Fe abundances, we find that the differences in the metallicities and elemental abundances of components of wide binaries are consistent with being due to observational uncertainties, in agreement with previous results for smaller and more restricted samples. The metallicity and elemental abundance consistency between wide binary components presented in this work confirms their common origin and bolsters the status of wide binaries as 'mini-open clusters'. Furthermore, this is evident that wide binaries are effectively co-eval and co-chemical, supporting their use for, e.g. constraining age-activity-rotation relations, the initial-final mass relation for white dwarfs and M-dwarf metallicity indicators. Additionally, we demonstrate that the common proper motion, common parallax pairs in TGAS with the most extreme separations (s ≳ 0.1 pc) typically have inconsistent metallicities, radial velocities or both and are therefore likely to be predominantly comprised of random alignments of unassociated stars with similar astrometry, in agreement with our previous results. Finally, we propose that wide binaries form an ideal data set with which we can test chemical tagging as a method to identify stars of common origin, particularly because the stars in wide binaries span a wide range of metallicities, much wider than that spanned by nearby open clusters.

Final Technical Report for subcontract number B612144

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mayali, X.; Marcu, O.

The original statement of work stipulated that the Subcontractor shall perform bacterial and algal cultivation and manipulation, microbe isolation, preparation of samples for sequencing and isotopic analysis, data analysis, and manuscript preparation. The Subcontractor shall work closely with Dr. Mayali and other LLNL scientists, and shall participate in monthly SFA meetings (either in person or by telephone). The Subcontractor shall deliver a final report at the conclusion of the work.

From Welfare to Work: Dynamic Lesson Plans for ESL Learners. Final Report. Fiscal Year 1998-99 [and] From Welfare to Work: Lessons for ESL Learners.

ERIC Educational Resources Information Center

Center for Literacy, Inc., Philadelphia, PA.

This document combines a final project report and the resulting guidebook of 20 lesson plans for English as a second language (ESL) instructors to help learners work within the Temporary Assistance to Needy Families (TANF) system and acquire effective job readiness strategies, choose a career path, and pursue employment. The report describes the…

Exploring the use of memory colors for image enhancement

NASA Astrophysics Data System (ADS)

Xue, Su; Tan, Minghui; McNamara, Ann; Dorsey, Julie; Rushmeier, Holly

2014-02-01

Memory colors refer to those colors recalled in association with familiar objects. While some previous work introduces this concept to assist digital image enhancement, their basis, i.e., on-screen memory colors, are not appropriately investigated. In addition, the resulting adjustment methods developed are not evaluated from a perceptual view of point. In this paper, we first perform a context-free perceptual experiment to establish the overall distributions of screen memory colors for three pervasive objects. Then, we use a context-based experiment to locate the most representative memory colors; at the same time, we investigate the interactions of memory colors between different objects. Finally, we show a simple yet effective application using representative memory colors to enhance digital images. A user study is performed to evaluate the performance of our technique.

Factors affecting Brucella spp. blood cultures positivity in children.

PubMed

Apa, Hurşit; Devrim, Ilker; Memur, Seyma; Günay, Ilker; Gülfidan, Gamze; Celegen, Mehmet; Bayram, Nuri; Karaarslan, Utku; Bağ, Ozlem; Işgüder, Rana; Oztürk, Aysel; Inan, Seyhan; Unal, Nurrettin

2013-03-01

Brucella infections have a wide spectrum of symptoms especially in children, making the diagnosis a complicated process. The gold standard for the final diagnosis for brucellosis is to identify the Brucella spp. isolated from blood or bone marrow cultures. The main purpose of this work was to evaluate the factors affecting the isolation of Brucella spp. from blood cultures. In our study, the ratio of fever, presence of hepatomegaly, and splenomegaly were found to be higher in the bacteremic group. In addition, C-reactive protein levels and liver function enzymes were found to be higher in the bacteremic group. In our opinion, while evaluating the febrile child with suspected Brucella infection, we highly recommend sampling blood cultures regardless of the history of previous antimicrobial therapy and duration of the symptoms.

Improved nearest codeword search scheme using a tighter kick-out condition

NASA Astrophysics Data System (ADS)

Hwang, Kuo-Feng; Chang, Chin-Chen

2001-09-01

Using a tighter kick-out condition as a faster approach to nearest codeword searches is proposed. The proposed scheme finds the nearest codeword that is identical to the one found using a full search. However, using our scheme, the search time is much shorter. Our scheme first establishes a tighter kick-out condition. Then, the temporal nearest codeword can be obtained from the codewords that survive the tighter condition. Finally, the temporal nearest codeword cooperatives with the query vector to constitute a better kick-out condition. In other words, more codewords can be excluded without actually computing the distances between the bypassed codewords and the query vector. Comparison to previous work are included to present the benefits of the proposed scheme in relation to search time.

Spin Hall effects in metallic antiferromagnets – perspectives for future spin-orbitronics

DOE PAGES

Sklenar, Joseph; Zhang, Wei; Jungfleisch, Matthias B.; ...

2016-03-07

In this paper, we investigate angular dependent spin-orbit torques from the spin Hall effect in a metallic antiferromagnet using the spin-torque ferromagnetic resonance technique. The large spin Hall effect exists in PtMn, a prototypical CuAu-I-type metallic antiferromagnet. By applying epitaxial growth, we previously reported an appreciable difference in spin-orbit torques for c- and a-axis orientated samples, implying anisotropic effects in magnetically ordered materials. In this work we demonstrate through bipolar-magnetic-field experiments a small but noticeable asymmetric behavior in the spin-transfer-torque that appears as a hysteresis effect. Finally, we also suggest that metallic antiferromagnets may be good candidates for the investigationmore » of various unidirectional effects related to novel spin-orbitronics phenomena.« less

About various definitions of life.

PubMed

Luisi, P L

1998-10-01

The old question of a definition of minimal life is taken up again at the aim of providing a forum for an updated discussion. Briefly discussed are the reasons why such an attempt has previously encountered scepticism, and why such an attempt should be renewed at this stage of the inquiry on the origin of life. Then some of the definitions of life presently used are cited and briefly discussed, starting with the definition adopted by NASA as a general working definition. It is shown that this is too limited if one wishes to provide a broad encompassing definition, and some extensions of it are presented and discussed. Finally it is shown how the different definitions of life reflect the main schools of thought that presently dominate the field on the origin of life.

Revised analysis of Ca 40 + Zr 96 fusion reactions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Esbensen, H.; Montagnoli, G.; Stefanini, A. M.

2016-03-10

Fusion data for 40Ca + 96Zr are analyzed by coupled-channels calculations that are based on a standard Woods-Saxon potential and include couplings to multiphonon excitations and transfer channels. The couplings to multiphonon excitations are the same as those used in a previous work. The transfer couplings are calibrated to reproduce the measured neutron transfer data. This type of calculation gives a poor fit to the fusion data. However, by multiplying the transfer couplings with a √2 one obtains an excellent fit. Finally, the scaling of the transfer strengths is supposed to simulate the combined effect of neutron and proton transfer,more » and the calculated one- and two-nucleon transfer cross sections are indeed in reasonable agreement with the measured cross sections.« less

The Predatory Bird Monitoring Scheme: identifying chemical risks to top predators in Britain.

PubMed

Walker, Lee A; Shore, Richard F; Turk, Anthony; Pereira, M Glória; Best, Jennifer

2008-09-01

The Predatory Bird Monitoring Scheme (PBMS) is a long term (>40 y), UK-wide, exposure monitoring scheme that determines the concentration of selected pesticides and pollutants in the livers and eggs of predatory birds. This paper describes how the PBMS works, and in particular highlights some of the key scientific and policy drivers for monitoring contaminants in predatory birds and describes the specific aims, scope, and methods of the PBMS. We also present previously unpublished data that illustrates how the PBMS has been used to demonstrate the success of mitigation measures in reversing chemical-mediated impacts; identify and evaluate chemical threats to species of high conservation value; and finally to inform and refine monitoring methodologies. In addition, we discuss how such schemes can also address wider conservation needs.

Adaptive neural control for a class of nonlinear time-varying delay systems with unknown hysteresis.

PubMed

Liu, Zhi; Lai, Guanyu; Zhang, Yun; Chen, Xin; Chen, Chun Lung Philip

2014-12-01

This paper investigates the fusion of unknown direction hysteresis model with adaptive neural control techniques in face of time-delayed continuous time nonlinear systems without strict-feedback form. Compared with previous works on the hysteresis phenomenon, the direction of the modified Bouc-Wen hysteresis model investigated in the literature is unknown. To reduce the computation burden in adaptation mechanism, an optimized adaptation method is successfully applied to the control design. Based on the Lyapunov-Krasovskii method, two neural-network-based adaptive control algorithms are constructed to guarantee that all the system states and adaptive parameters remain bounded, and the tracking error converges to an adjustable neighborhood of the origin. In final, some numerical examples are provided to validate the effectiveness of the proposed control methods.

Dilution jet configurations in a reverse flow combustor. M.S. Thesis Final Report

NASA Technical Reports Server (NTRS)

Zizelman, J.

1985-01-01

Results of measurements of both temperature and velocity fields within a reverse flow combustor are presented. Flow within the combustor is acted upon by perpendicularly injected cooling jets introduced at three different locations along the inner and outer walls of the combustor. Each experiment is typified by a group of parameters: density ratio, momentum ratio, spacing ratio, and confinement parameter. Measurements of both temperature and velocity are presented in terms of normalized profiles at azimuthal positions through the turn section of the combustion chamber. Jet trajectories defined by minimum temperature and maximum velocity give a qualitative indication of the location of the jet within the cross flow. Results of a model from a previous temperature study are presented in some of the plots of data from this work.

Methodology for turbulence code validation: Quantification of simulation-experiment agreement and application to the TORPEX experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ricci, Paolo; Theiler, C.; Fasoli, A.

A methodology for plasma turbulence code validation is discussed, focusing on quantitative assessment of the agreement between experiments and simulations. The present work extends the analysis carried out in a previous paper [P. Ricci et al., Phys. Plasmas 16, 055703 (2009)] where the validation observables were introduced. Here, it is discussed how to quantify the agreement between experiments and simulations with respect to each observable, how to define a metric to evaluate this agreement globally, and - finally - how to assess the quality of a validation procedure. The methodology is then applied to the simulation of the basic plasmamore » physics experiment TORPEX [A. Fasoli et al., Phys. Plasmas 13, 055902 (2006)], considering both two-dimensional and three-dimensional simulation models.« less

Noether’s second theorem and Ward identities for gauge symmetries

DOE PAGES

Avery, Steven G.; Schwab, Burkhard U. W.

2016-02-04

Recently, a number of new Ward identities for large gauge transformations and large diffeomorphisms have been discovered. Some of the identities are reinterpretations of previously known statements, while some appear to be genuinely new. We present and use Noether’s second theorem with the path integral as a powerful way of generating these kinds of Ward identities. We reintroduce Noether’s second theorem and discuss how to work with the physical remnant of gauge symmetry in gauge fixed systems. We illustrate our mechanism in Maxwell theory, Yang-Mills theory, p-form field theory, and Einstein-Hilbert gravity. We comment on multiple connections between Noether’s secondmore » theorem and known results in the recent literature. Finally, our approach suggests a novel point of view with important physical consequences.« less

Melting behavior of nanometer sized gold isomers

NASA Astrophysics Data System (ADS)

Liu, H. B.; Ascencio, J. A.; Perez-Alvarez, M.; Yacaman, M. J.

2001-09-01

In the present work, the melting behavior of nanometer sized gold isomers was studied using a tight-binding potential with a second momentum approximation. The cases of cuboctahedra, icosahedra, Bagley decahedra, Marks decahedra and star-like decahedra were considered. We calculated the temperature dependence of the total energy and volume during melting and the melting point for different types and sizes of clusters. In addition, the structural evolutions of the nanosized clusters during the melting transition were monitored and revealed. It is found that the melting process has three characteristic time periods for the intermediate nanosized clusters. The whole process includes surface disordering and reordering, followed by surface melting and a final rapid overall melting. This is a new observation, which it is in contrast with previous reports where surface melting is the dominant step.

Whatever happened to "What might have been"? Regrets, happiness, and maturity.

PubMed

King, Laura A; Hicks, Joshua A

2007-10-01

Although lost opportunities and mistaken expectations are unpleasant to think and talk about, these experiences may have a role to play in personality development. Drawing on research using narratives of lost possible selves, the authors review the relations of regrettable experiences to 2 important and independent aspects of maturity, happiness and complexity. Thinking about a lost possible self is related to concurrent regrets, distress, and lowered well-being; however, elaborating on a lost possible self is related, concurrently, to complexity and predicts complexity, prospectively, over time. In this article, the authors describe the role that regrettable experiences have in promoting both happiness and complexity. Finally, expanding on previous work, the authors examine potential affordances of happy maturity and suggest psychological capacities that may promote happy maturity. Copyright 2007 APA, all rights reserved.

Mechanics and statistics of the worm-like chain

NASA Astrophysics Data System (ADS)

Marantan, Andrew; Mahadevan, L.

2018-02-01

The worm-like chain model is a simple continuum model for the statistical mechanics of a flexible polymer subject to an external force. We offer a tutorial introduction to it using three approaches. First, we use a mesoscopic view, treating a long polymer (in two dimensions) as though it were made of many groups of correlated links or "clinks," allowing us to calculate its average extension as a function of the external force via scaling arguments. We then provide a standard statistical mechanics approach, obtaining the average extension by two different means: the equipartition theorem and the partition function. Finally, we work in a probabilistic framework, taking advantage of the Gaussian properties of the chain in the large-force limit to improve upon the previous calculations of the average extension.

Equilibrium concentration profiles and sedimentation kinetics of colloidal gels under gravitational stress

NASA Astrophysics Data System (ADS)

Buzzaccaro, S.; Secchi, E.; Brambilla, G.; Piazza, R.; Cipelletti, L.

2012-07-01

We study the sedimentation of colloidal gels by using a combination of light scattering, polarimetry and video imaging. The asymptotic concentration profiles φ(z,t → ∞) exhibit remarkable scaling properties: profiles for gels prepared at different initial volume fractions and particle interactions can be superimposed onto a single master curve by using suitable reduced variables. We show theoretically that this behavior stems from a power law dependence of the compressive elastic modulus versus φ, which we directly test experimentally. The sedimentation kinetics comprises an initial latency stage, followed by a rapid collapse where the gel height h decreases at constant velocity and a final compaction stage characterized by a stretched exponential relaxation of h toward a plateau. Analogies and differences with previous works are briefly discussed.

Approach/Avoidance Orientations Affect Self-Construal and Identification with In-group

PubMed Central

Nussinson, Ravit; Häfner, Michael; Seibt, Beate; Strack, Fritz; Trope, Yaacov

2011-01-01

Approach and avoidance are two basic motivational orientations. Their activation influences cognitive and perceptive processes: Previous work suggests that an approach orientation instigates a focus on larger units as compared to avoidance. Study 1 confirms this assumption using a paradigm that more directly taps a person’s tendency to represent objects as belonging to small or large units than prior studies. It was further predicted that the self should also be represented as belonging to larger units, and hence be more interdependent under approach than under avoidance. Study 2 supports this prediction. As a consequence of this focus on belonging to larger units, it was finally predicted that approach results in a stronger identification with one’s in-group than avoidance. Studies 3 and 4 support that prediction. PMID:22844229

Reciprocity in computer-human interaction: source-based, norm-based, and affect-based explanations.

PubMed

Lee, Seungcheol Austin; Liang, Yuhua Jake

2015-04-01

Individuals often apply social rules when they interact with computers, and this is known as the Computers Are Social Actors (CASA) effect. Following previous work, one approach to understand the mechanism responsible for CASA is to utilize computer agents and have the agents attempt to gain human compliance (e.g., completing a pattern recognition task). The current study focuses on three key factors frequently cited to influence traditional notions of compliance: evaluations toward the source (competence and warmth), normative influence (reciprocity), and affective influence (mood). Structural equation modeling assessed the effects of these factors on human compliance with computer request. The final model shows that norm-based influence (reciprocity) increased the likelihood of compliance, while evaluations toward the computer agent did not significantly influence compliance.

Packaging stiff polymers in small containers: A molecular dynamics study

NASA Astrophysics Data System (ADS)

Rapaport, D. C.

2016-09-01

The question of how stiff polymers are able to pack into small containers is particularly relevant to the study of DNA packaging in viruses. A reduced version of the problem based on coarse-grained representations of the main components of the system—the DNA polymer and the spherical viral capsid—has been studied by molecular dynamics simulation. The results, involving longer polymers than in earlier work, show that as polymers become more rigid there is an increasing tendency to self-organize as spools that wrap from the inside out, rather than the inverse direction seen previously. In the final state, a substantial part of the polymer is packed into one or more coaxial spools, concentrically layered with different orientations, a form of packaging achievable without twisting the polymer.

A proposal of an architecture for the coordination level of intelligent machines

NASA Technical Reports Server (NTRS)

Beard, Randall; Farah, Jeff; Lima, Pedro

1993-01-01

The issue of obtaining a practical, structured, and detailed description of an architecture for the Coordination Level of Center for Intelligent Robotic Systems for Sapce Exploration (CIRSSE) Testbed Intelligent Controller is addressed. Previous theoretical and implementation works were the departure point for the discussion. The document is organized as follows: after this introductory section, section 2 summarizes the overall view of the Intelligent Machine (IM) as a control system, proposing a performance measure on which to base its design. Section 3 addresses with some detail implementation issues. An hierarchic petri-net with feedback-based learning capabilities is proposed. Finally, section 4 is an attempt to address the feedback problem. Feedback is used for two functions: error recovery and reinforcement learning of the correct translations for the petri-net transitions.

On-Board Sound Intensity (OBSI) study : phase 2.

DOT National Transportation Integrated Search

2014-05-01

This is a continuation effort of previous research (Modeling of Quieter Pavement in Florida) : and as such is a sister report to the previous final report. Both research efforts pertain to the : noise created at the tire/pavement interface, which con...

78 FR 57293 - Medicaid Program; State Disproportionate Share Hospital Allotment Reductions

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-18

... reductions are prospective, not retrospective. Comment: One commenter requested clarification on how the... establish prospective DSH allotment reductions adjustments that rely on final or completed data from previous years. Response: The final rule establishes prospective DSH allotment reductions based on the most...

Factors affecting the return to work of total hip arthroplasty due to of developmental hip dysplasia in in young patients.

PubMed

Oken, Fuad O; Yildirim, Ozgur A; Asilturk, Mehmet

2018-06-01

The aim of this study was to examine the factors affecting return to work after Total hip arthroplasty (THA) applied for coxarthrosis due to developmental hip dysplasia (DDH). The study included 51 patients aged <60 years in the period 2004-2010. The demographic information was recorded for all patients and the pre-postoperative Modified Harris score, EQ-5D, EQ-5D VAS and Grimby activity score. With an evaluation of the current employment status at the final follow-up examination. Preoperatively, 21 patients were employed, 16 were unemployed and 14 were housewives, none of whom were able to perform housework tasks. Postoperatively, 30 patients were employed and 10 were unemployed. One of the previously employed patients decided preoperatively to retire and was therefore not employed postoperatively. Of the 14 housewives, 9 were able to undertake the housework themselves postoperatively. The mean time of return to work was 13.4 weeks. Factors affecting finding work postoperatively were determined to be body mass index, National Occupational Level, whether or not osteotomy was applied and the preoperative duration of unemployment. As coxarthrosis associated with DDH develops earlier than primary coxarthrosis, these patients undergo surgery at a younger age and the vast majority are of working age. THA applied for coxarthrosis on the basis of DDH enables most patients to return to their preoperative work and offers the opportunity of finding work to some of those who were unemployed. This increases the contribution of these patients to the national economy.

Recommendation of LightSquared Subsidiary LLC : [the working group] Final Report and Appendices 1-4

DOT National Transportation Integrated Search

2011-01-01

This is the final report of the Working Group (WG) that was formed to study the GPS overload/desensitization issue as described by the Federal Communications Commission (FCC) in DA 11-133. On February 25, 2011, LightSquared and the United States Glob...

20 CFR 411.660 - Is SSA's decision final?

Code of Federal Regulations, 2012 CFR

2012-04-01

... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Is SSA's decision final? 411.660 Section 411.660 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Ticket to Work Program Dispute Resolution Disputes Between Employment Networks and Program Managers § 411...

20 CFR 411.660 - Is SSA's decision final?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Is SSA's decision final? 411.660 Section 411.660 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Ticket to Work Program Dispute Resolution Disputes Between Employment Networks and Program Managers § 411...

20 CFR 411.660 - Is SSA's decision final?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Is SSA's decision final? 411.660 Section 411.660 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Ticket to Work Program Dispute Resolution Disputes Between Employment Networks and Program Managers § 411...

20 CFR 411.660 - Is SSA's decision final?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Is SSA's decision final? 411.660 Section 411.660 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Ticket to Work Program Dispute Resolution Disputes Between Employment Networks and Program Managers § 411...

20 CFR 411.660 - Is SSA's decision final?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Is SSA's decision final? 411.660 Section 411.660 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Ticket to Work Program Dispute Resolution Disputes Between Employment Networks and Program Managers § 411...

Worksite interventions for preventing physical deterioration among employees in job-groups with high physical work demands: background, design and conceptual model of FINALE.

PubMed

Holtermann, Andreas; Jørgensen, Marie B; Gram, Bibi; Christensen, Jeanette R; Faber, Anne; Overgaard, Kristian; Ektor-Andersen, John; Mortensen, Ole S; Sjøgaard, Gisela; Søgaard, Karen

2010-03-09

A mismatch between individual physical capacities and physical work demands enhance the risk for musculoskeletal disorders, poor work ability and sickness absence, termed physical deterioration. However, effective intervention strategies for preventing physical deterioration in job groups with high physical demands remains to be established. This paper describes the background, design and conceptual model of the FINALE programme, a framework for health promoting interventions at 4 Danish job groups (i.e. cleaners, health-care workers, construction workers and industrial workers) characterized by high physical work demands, musculoskeletal disorders, poor work ability and sickness absence. A novel approach of the FINALE programme is that the interventions, i.e. 3 randomized controlled trials (RCT) and 1 exploratory case-control study are tailored to the physical work demands, physical capacities and health profile of workers in each job-group. The RCT among cleaners, characterized by repetitive work tasks and musculoskeletal disorders, aims at making the cleaners less susceptible to musculoskeletal disorders by physical coordination training or cognitive behavioral theory based training (CBTr). Because health-care workers are reported to have high prevalence of overweight and heavy lifts, the aim of the RCT is long-term weight-loss by combined physical exercise training, CBTr and diet. Construction work, characterized by heavy lifting, pushing and pulling, the RCT aims at improving physical capacity and promoting musculoskeletal and cardiovascular health. At the industrial work-place characterized by repetitive work tasks, the intervention aims at reducing physical exertion and musculoskeletal disorders by combined physical exercise training, CBTr and participatory ergonomics. The overall aim of the FINALE programme is to improve the safety margin between individual resources (i.e. physical capacities, and cognitive and behavioral skills) and physical work demands, and thereby reduce the physical deterioration in a long term perspective by interventions tailored for each respective job-group. The FINALE programme has the potential to provide evidence-based knowledge of significant importance for public health policy and health promotion strategies for employees at high risk for physical deterioration. ISRCTN96241850, NCT01015716 and NCT01007669.

Worksite interventions for preventing physical deterioration among employees in job-groups with high physical work demands: Background, design and conceptual model of FINALE

PubMed Central

2010-01-01

Background A mismatch between individual physical capacities and physical work demands enhance the risk for musculoskeletal disorders, poor work ability and sickness absence, termed physical deterioration. However, effective intervention strategies for preventing physical deterioration in job groups with high physical demands remains to be established. This paper describes the background, design and conceptual model of the FINALE programme, a framework for health promoting interventions at 4 Danish job groups (i.e. cleaners, health-care workers, construction workers and industrial workers) characterized by high physical work demands, musculoskeletal disorders, poor work ability and sickness absence. Methods/Design A novel approach of the FINALE programme is that the interventions, i.e. 3 randomized controlled trials (RCT) and 1 exploratory case-control study are tailored to the physical work demands, physical capacities and health profile of workers in each job-group. The RCT among cleaners, characterized by repetitive work tasks and musculoskeletal disorders, aims at making the cleaners less susceptible to musculoskeletal disorders by physical coordination training or cognitive behavioral theory based training (CBTr). Because health-care workers are reported to have high prevalence of overweight and heavy lifts, the aim of the RCT is long-term weight-loss by combined physical exercise training, CBTr and diet. Construction work, characterized by heavy lifting, pushing and pulling, the RCT aims at improving physical capacity and promoting musculoskeletal and cardiovascular health. At the industrial work-place characterized by repetitive work tasks, the intervention aims at reducing physical exertion and musculoskeletal disorders by combined physical exercise training, CBTr and participatory ergonomics. The overall aim of the FINALE programme is to improve the safety margin between individual resources (i.e. physical capacities, and cognitive and behavioral skills) and physical work demands, and thereby reduce the physical deterioration in a long term perspective by interventions tailored for each respective job-group. Discussion The FINALE programme has the potential to provide evidence-based knowledge of significant importance for public health policy and health promotion strategies for employees at high risk for physical deterioration. Trial registrations ISRCTN96241850, NCT01015716 and NCT01007669 PMID:20214807

In-Vehicle Information Systems Behavioral Model and Design Support: Final Report

DOT National Transportation Integrated Search

2000-02-16

A great deal of effort went into producing both the model and the prototype software for this contract. The purpose of this final report is not to duplicate the information provided about these and other topics in previous reports. The purpose is to ...

An Experimental Approach to Debuccalization and Supplementary Gestures

ERIC Educational Resources Information Center

O'Brien, Jeremy

2012-01-01

Debuccalization is a weakening phenomenon whereby various consonants reduce to laryngeals. Examples include Spanish s-aspiration (s becomes h word-finally) and English t-glottalization (t becomes glottal stop syllable-finally). Previous analyses of debuccalization view it as a lenition process that deletes or manipulates formal phonological…

Episodic memories predict adaptive value-based decision-making

PubMed Central

Murty, Vishnu; FeldmanHall, Oriel; Hunter, Lindsay E.; Phelps, Elizabeth A; Davachi, Lila

2016-01-01

Prior research illustrates that memory can guide value-based decision-making. For example, previous work has implicated both working memory and procedural memory (i.e., reinforcement learning) in guiding choice. However, other types of memories, such as episodic memory, may also influence decision-making. Here we test the role for episodic memory—specifically item versus associative memory—in supporting value-based choice. Participants completed a task where they first learned the value associated with trial unique lotteries. After a short delay, they completed a decision-making task where they could choose to re-engage with previously encountered lotteries, or new never before seen lotteries. Finally, participants completed a surprise memory test for the lotteries and their associated values. Results indicate that participants chose to re-engage more often with lotteries that resulted in high versus low rewards. Critically, participants not only formed detailed, associative memories for the reward values coupled with individual lotteries, but also exhibited adaptive decision-making only when they had intact associative memory. We further found that the relationship between adaptive choice and associative memory generalized to more complex, ecologically valid choice behavior, such as social decision-making. However, individuals more strongly encode experiences of social violations—such as being treated unfairly, suggesting a bias for how individuals form associative memories within social contexts. Together, these findings provide an important integration of episodic memory and decision-making literatures to better understand key mechanisms supporting adaptive behavior. PMID:26999046

The evolution of honest communication: integrating social and physiological costs of ornamentation.

PubMed

Tibbetts, Elizabeth A

2014-10-01

Much research on animal communication has addressed how costs such as social costs or physiological costs favor the accuracy of signals. Previous work has largely considered these costs separately, but we may be missing essential connections by studying costs in isolation. After all, social interactions produce rapid changes in hormone titers which can then affect individual behavior and physiology. As a result, social costs are likely to have widespread physiological consequences. Here, I present a new perspective on the factors that maintain honest signals by describing how the interplay between social costs and physiological costs may maintain an accurate link between an animal's abilities and ornament elaboration. I outline three specific mechanisms by which the interaction between social behavior and hormones could favor honest signals and present specific predictions for each of the three models. Then, I review how ornaments alter agonistic behavior, agonistic behavior influences hormones, and how these hormonal effects influence fitness. I also describe the few previous studies that have directly tested how ornaments influence hormones. Finally, opportunities for future work are discussed. Considering the interaction between social behavior and physiology may address some challenges associated with both social and physiological models of costs. Understanding the dynamic feedbacks between physiology and social costs has potential to transform our understanding of the stability of animals' communication systems. © The Author 2014. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. For permissions please email: journals.permissions@oup.com.

A FAST ITERATIVE METHOD FOR SOLVING THE EIKONAL EQUATION ON TETRAHEDRAL DOMAINS

PubMed Central

Fu, Zhisong; Kirby, Robert M.; Whitaker, Ross T.

2014-01-01

Generating numerical solutions to the eikonal equation and its many variations has a broad range of applications in both the natural and computational sciences. Efficient solvers on cutting-edge, parallel architectures require new algorithms that may not be theoretically optimal, but that are designed to allow asynchronous solution updates and have limited memory access patterns. This paper presents a parallel algorithm for solving the eikonal equation on fully unstructured tetrahedral meshes. The method is appropriate for the type of fine-grained parallelism found on modern massively-SIMD architectures such as graphics processors and takes into account the particular constraints and capabilities of these computing platforms. This work builds on previous work for solving these equations on triangle meshes; in this paper we adapt and extend previous two-dimensional strategies to accommodate three-dimensional, unstructured, tetrahedralized domains. These new developments include a local update strategy with data compaction for tetrahedral meshes that provides solutions on both serial and parallel architectures, with a generalization to inhomogeneous, anisotropic speed functions. We also propose two new update schemes, specialized to mitigate the natural data increase observed when moving to three dimensions, and the data structures necessary for efficiently mapping data to parallel SIMD processors in a way that maintains computational density. Finally, we present descriptions of the implementations for a single CPU, as well as multicore CPUs with shared memory and SIMD architectures, with comparative results against state-of-the-art eikonal solvers. PMID:25221418

Modeling the impact of common noise inputs on the network activity of retinal ganglion cells

PubMed Central

Ahmadian, Yashar; Shlens, Jonathon; Pillow, Jonathan W.; Kulkarni, Jayant; Litke, Alan M.; Chichilnisky, E. J.; Simoncelli, Eero; Paninski, Liam

2013-01-01

Synchronized spontaneous firing among retinal ganglion cells (RGCs), on timescales faster than visual responses, has been reported in many studies. Two candidate mechanisms of synchronized firing include direct coupling and shared noisy inputs. In neighboring parasol cells of primate retina, which exhibit rapid synchronized firing that has been studied extensively, recent experimental work indicates that direct electrical or synaptic coupling is weak, but shared synaptic input in the absence of modulated stimuli is strong. However, previous modeling efforts have not accounted for this aspect of firing in the parasol cell population. Here we develop a new model that incorporates the effects of common noise, and apply it to analyze the light responses and synchronized firing of a large, densely-sampled network of over 250 simultaneously recorded parasol cells. We use a generalized linear model in which the spike rate in each cell is determined by the linear combination of the spatio-temporally filtered visual input, the temporally filtered prior spikes of that cell, and unobserved sources representing common noise. The model accurately captures the statistical structure of the spike trains and the encoding of the visual stimulus, without the direct coupling assumption present in previous modeling work. Finally, we examined the problem of decoding the visual stimulus from the spike train given the estimated parameters. The common-noise model produces Bayesian decoding performance as accurate as that of a model with direct coupling, but with significantly more robustness to spike timing perturbations. PMID:22203465

Strong Langmuir Turbulence and Four-Wave Mixing

NASA Astrophysics Data System (ADS)

Glanz, James

1991-02-01

The staircase expansion is a new mathematical technique for deriving reduced, nonlinear-PDE descriptions from the plasma-moment equations. Such descriptions incorporate only the most significant linear and nonlinear terms of more complex systems. The technique is used to derive a set of Dawson-Zakharov or "master" equations, which unify and generalize previous work and show the limitations of models commonly used to describe nonlinear plasma waves. Fundamentally new wave-evolution equations are derived that admit of exact nonlinear solutions (solitary waves). Analytic calculations illustrate the competition between well-known effects of self-focusing, which require coupling to ion motion, and pure-electron nonlinearities, which are shown to be especially important in curved geometries. Also presented is an N -moment hydrodynamic model derived from the Vlasov equation. In this connection, the staircase expansion is shown to remain useful for all values of N >= 3. The relevance of the present work to nonlocally truncated hierarchies, which more accurately model dissipation, is briefly discussed. Finally, the general formalism is applied to the problem of electromagnetic emission from counterpropagating Langmuir pumps. It is found that previous treatments have neglected order-unity effects that increase the emission significantly. Detailed numerical results are presented to support these conclusions. The staircase expansion--so called because of its appearance when written out--should be effective whenever the largest contribution to the nonlinear wave remains "close" to some given frequency. Thus the technique should have application to studies of wake-field acceleration schemes and anomalous damping of plasma waves.

Assessing Complex Emergency Management with Clinical Case-Vignettes: A Validation Study

PubMed Central

2015-01-01

Objective To evaluate whether responses to dynamic case-vignettes accurately reflect actual practices in complex emergency situations. We hypothesized that when obstetricians were faced with vignette of emergency situation identical to one they previously managed, they would report the management strategy they actually used. On the other hand, there is no reason to suppose that their response to a vignette based on a source case managed by another obstetrician would be the same as the actual management. Methods A multicenter vignette-based study was used in 7 French maternity units. We chose the example of severe postpartum hemorrhage (PPH) to study the use of case-vignettes for assessing the management of complex situations. We developed dynamic case-vignettes describing incidents of PPH in several steps, using documentation in patient files. Vignettes described the postpartum course and included multiple-choice questions detailing proposed clinical care. Each participating obstetrician was asked to evaluate 4 case-vignettes: 2 directly derived from cases they previously managed and 2 derived from other obstetricians’ cases. We compared the final treatment decision in vignette responses to those documented in the source-case by the overall agreement and the Kappa coefficient, both for the cases the obstetricians previously managed and the cases of others. Results Thirty obstetricians participated. Overall agreement between final treatment decisions in case-vignettes and documented care for cases obstetricians previously managed was 82% (Kappa coefficient: 0.75, 95% CI [0.62–0.88]). Overall agreement between final treatment decisions in case-vignettes and documented care in vignettes derived from other obstetricians’ cases was only 48% (Kappa coefficient: 0.30, 95% CI [0.12–0.48]). Final agreement with documented care was significantly better for cases based on their own previous cases than for others (p<0.001). Conclusions Dynamic case-vignettes accurately reflect actual practices in complex emergency situations. Therefore, they can be used to assess the quality of management in these situations. PMID:26383261

Impact of Cancer on Work and Education Among Adolescent and Young Adult Cancer Survivors

PubMed Central

Parsons, Helen M.; Harlan, Linda C.; Lynch, Charles F.; Hamilton, Ann S.; Wu, Xiao-Cheng; Kato, Ikuko; Schwartz, Stephen M.; Smith, Ashley W.; Keel, Gretchen; Keegan, Theresa H.M.

2012-01-01

Purpose To examine the impact of cancer on work and education in a sample of adolescent and young adult (AYA) patients with cancer. Patients and Methods By using the Adolescent and Young Adult Health Outcomes and Patient Experience Study (AYA HOPE)—a cohort of 463 recently diagnosed patients age 15 to 39 years with germ cell cancer, Hodgkin's lymphoma, non-Hodgkin's lymphoma, sarcoma, and acute lymphocytic leukemia from participating Surveillance, Epidemiology, and End Results (SEER) cancer registries—we evaluated factors associated with return to work/school after cancer diagnosis, a belief that cancer had a negative impact on plans for work/school, and reported problems with work/school after diagnosis by using descriptive statistics, χ2 tests, and multivariate logistic regression. Results More than 72% (282 of 388) of patients working or in school full-time before diagnosis had returned to full-time work or school 15 to 35 months postdiagnosis compared with 34% (14 of 41) of previously part-time workers/students, 7% (one of 14) of homemakers, and 25% (five of 20) of unemployed/disabled patients (P < .001). Among full-time workers/students before diagnosis, patients who were uninsured (odds ratio [OR], 0.21; 95% CI, 0.07 to 0.67; no insurance v employer-/school-sponsored insurance) or quit working directly after diagnosis (OR, 0.15; 95% CI, 0.06 to 0.37; quit v no change) were least likely to return. Very intensive cancer treatment and quitting work/school were associated with a belief that cancer negatively influenced plans for work/school. Finally, more than 50% of full-time workers/students reported problems with work/studies after diagnosis. Conclusion Although most AYA patients with cancer return to work after cancer, treatment intensity, not having insurance, and quitting work/school directly after diagnosis can influence work/educational outcomes. Future research should investigate underlying causes for these differences and best practices for effective transition of these cancer survivors to the workplace/school after treatment. PMID:22614977

Final Report May 1, 2012 to May 31, 2015: "Theoretical Studies in Elementary Particle Physics"

DOE Office of Scientific and Technical Information (OSTI.GOV)

Collins, John C.; Roiban, Radu

2015-08-19

This final report summarizes work at Penn State University from May 1, 2012 to May 31, 2015. The work was in theoretical elementary particle physics. Many new results in perturbative QCD, in string theory, and in related areas were obtained, with a substantial impact on the experimental program.

75 FR 54871 - National Drinking Water Advisory Council's Climate Ready Water Utilities Working Group Meeting...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-09

... ENVIRONMENTAL PROTECTION AGENCY [FRL-9198-8] National Drinking Water Advisory Council's Climate... final in-person meeting of the Climate Ready Water Utilities (CRWU) Working Group of the National Drinking Water Advisory Council (NDWAC). The purpose of this meeting is to review and discuss final changes...

Youth Employment. Final Recommendations of the State Superintendent's Task Force.

ERIC Educational Resources Information Center

Wisconsin State Dept. of Public Instruction, Madison.

This report contains the final recommendations of the task force on youth employment for the state of Wisconsin. The task force was specifically charged with studying issues related to working teenagers, reviewing existing laws and regulations on child labor, and developing recommendations to ensure that when teenagers work, their jobs do not…

Decree-Law No. 199/88, 31 May 1988.

PubMed

1988-01-01

This Decree-Law establishes criteria for the determination of final compensation for expropriation or nationalization of land or agricultural capital. The lack of legal definition of criteria for the determination of such final compensation was a gap in recent Portuguese legislation on land reform. Although the holdings of many landlords and farmers had been nationalized or expropriated after 11 March 1975, the compensation obtained prior to the enactment of this Decree-Law was provisional and reflected outdated values. This Decree-Law closes this gap by establishing the criteria for the determination of final compensation with adjusted value. Under it, any farmer whose land or capital has been nationalized or expropriated since March 1975 may apply for final compensation, from which shall be deducted the value of any provisional compensation previously obtained and any property previously devolved as a "right of reserve" pursuant to pertinent legislation (see Law No. 109/88 of 26 September 1988 and Decree No. 44/88 of 14 December 1988). The final compensation shall be determined by administrative procedure in which the Ministry of Agriculture, Fisheries, and Food; the Ministry of Finance; and the applicant are represented. full text

Safeguards and security research and development: Progress report, October 1994--September 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rutherford, D.R.; Henriksen, P.W.

The primary goal of the Los Alamos Safeguards and Security Technology Development Program, International Safeguards, and other Safeguards and Security Programs is to continue to be the center of excellence in the field of Safeguards and Security. This annual report for 1995 describes those scientific and engineering projects that contribute to all of the aforementioned programs. The authors have presented the information in a different format from previous annual reports. Part I is devoted to Nuclear Material Measurement Systems. Part II contains projects that are specific to Integrated Safeguards Systems. Part III highlights Safeguards Systems Effectiveness Evaluations and Part IVmore » is a compilation of highlights from Information Assurance projects. Finally Part V highlights work on the projects at Los Alamos for International Safeguards. The final part of this annual report lists titles and abstracts of Los Alamos Safeguards and Security Technology Development reports, technical journal articles, and conference papers that were presented and published in 1995. This is the last annual report in this format. The authors wish to thank all of the individuals who have contributed to this annual report and made it so successful over the years.« less

Surface shift of the occupied and unoccupied 4f levels of the rare-earth metals

NASA Astrophysics Data System (ADS)

Aldén, M.; Johansson, B.; Skriver, H. L.

1995-02-01

The surface energy shifts of the occupied and unoccupied 4f levels for the lanthanide metals have been calculated from first principles by means of a Green's-function technique within the tight-binding linear muffin-tin orbitals method. We use the concept of complete screening to identify the occupied and unoccupied 4f energy level shifts as the surface segregation energy of a 4fn-1 and 4fn+1 impurity atom, respectively, in a 4fn host metal. The calculations include both initial- and final-state effects and give values that are considerably lower than those measured on polycrystalline samples as well as those found in previous initial-state model calculations. The present theory agrees well with very recent high-resolution, single-crystal film measurements for Gd, Tb, Dy, Ho, Er, Tm, and Lu. We furthermore utilize the unique possibility offered by the lanthanide metals to clarify the roles played by the initial and the different final states of the core-excitation process, permitted by the fact that the so-called initial-state effect is identical upon 4f removal and 4f addition. Surface energy and work function calculations are also reported.

The effect of electrostatic and gravity force on offset wire inside tube

NASA Astrophysics Data System (ADS)

Oh, S. H.; Hazineh, D.; Wang, C.

2018-04-01

In a straw-tube detector, a wire that is offset with respect to the tube axis experiences a Coulomb force when high voltage is applied between the anode wire and the tube. This force results in a shifting of the wire and straw, in addition to the gravitational sag, and is a function of the tube and wire radius, initial offset, high voltage, tension and length. The presence of such effects is well known, but the precise magnitude of the shift for the anode wires under conditions of detector operation have not been previously documented with measurable confidence. In this work, we provide the first systematic measurements for the wire shift in straw-tube detectors due to gravity and the electrostatic force using an x-ray scanner developed for the Mu2e experiment. The data are compared to the solutions of the differential equations governing the system, and we find a good match between the two. The solutions can predict the final wire and straw positions from the initial positions measured without the high voltage, and the final wire and straw positions can then be used as an input to the track reconstruction software to improve the track position resolution.

Robustly stable adaptive control of a tandem of master-slave robotic manipulators with force reflection by using a multiestimation scheme.

PubMed

Ibeas, Asier; de la Sen, Manuel

2006-10-01

The problem of controlling a tandem of robotic manipulators composing a teleoperation system with force reflection is addressed in this paper. The final objective of this paper is twofold: 1) to design a robust control law capable of ensuring closed-loop stability for robots with uncertainties and 2) to use the so-obtained control law to improve the tracking of each robot to its corresponding reference model in comparison with previously existing controllers when the slave is interacting with the obstacle. In this way, a multiestimation-based adaptive controller is proposed. Thus, the master robot is able to follow more accurately the constrained motion defined by the slave when interacting with an obstacle than when a single-estimation-based controller is used, improving the transparency property of the teleoperation scheme. The closed-loop stability is guaranteed if a minimum residence time, which might be updated online when unknown, between different controller parameterizations is respected. Furthermore, the analysis of the teleoperation and stability capabilities of the overall scheme is carried out. Finally, some simulation examples showing the working of the multiestimation scheme complete this paper.

Final report for project "Next-Generation Semiconductors for Solar Photoelectrolysis"

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khalifah, Peter

2016-09-15

In this paper, effective methods have been developed for preparing high-quality LaTiO 2N films on conductive La 5Ti 5O 17 substrates that can serve as photoanodes for photoelectrochemical water oxidation. One paper has been written by the post-doc who completed this comprehensive, interdisciplinary study, and it is presently being finalized for submission. Our approach to this system integrates expertise that we have developed in single crystal growth, thin film growth, and thin film post-processing. Through this work, LTON films have been fully optimized for light harvesting, as their band gap is optimally matched with the incident solar spectrum and themore » film thicknesses have been optimized based on the absolute absorption coefficients that we have measured for this system. The next step is to optimize the co-catalyst functionalization and the solution conditions to maximize the catalytic activity for water oxidation. Since the preliminary tests described here were done without a water oxidation co-catalyst, and since good water oxidation catalysts have previously been identified based on studies of powder samples, this next step is highly likely to be successful.« less

A WEB based approach in biomedical engineering design education.

PubMed

Enderle, J D; Browne, A F; Hallowell, M B

1997-01-01

As part of the accreditation process for university engineering programs, students are required to complete a minimum number of design credits in their course of study, typically at the senior level. Many call this the capstone course. Engineering design is a course or series of courses that bring together concepts and principles that students learn in their field of study--it involves the integration and extension of material learned in their major toward a specific project. Most often, the student is exposed to system-wide analysis, critique and evaluation for the first time. Design is an iterative, decision making process in which the student optimally applies previously learned material to meet a stated objective. At the University of Connecticut, students work in teams of 3-4 members and work on externally sponsored projects. To facilitate working with sponsors, a WEB based approach is used for reporting the progress on projects. Students are responsible for creating their own WEB sites that support both html and pdf formats. Students provide the following deliverables: weekly progress reports, project statement, specifications, project proposal, interim report, and final report. A senior design homepage also provides links to data books and other resources for use by students. We are also planning distance learning experiences between two campuses so students can work on projects that involve the use of video conferencing.

The relation between indicators of low employment quality and attendance behavior in countries of the European Union.

PubMed

Janssens, Heidi; Braeckman, Lutgart; De Clercq, Bart; De Bacquer, Dirk; Clays, Els

2017-12-01

Previous research demonstrated an association between low employment quality and lower sickness absence, which may be explained by presenteeism. Therefore, this study aimed exploring the relation between three indicators of employment quality (long working hours, precarious employment, job insecurity) and attendance behavior. The association between employment quality and attendance behavior was investigated in 28.999 workers (mean age: 40.0 years, 53% males) of the fifth wave of the European Working Conditions Survey, using multilevel multinomial logistic regression analysis. Attendance behavior was operationalized as different combinations of sickness absence and presenteeism. Those working >48 h/week, had a higher risk to report presenteeism (with or without sickness absence). They had a lower risk to report sickness absence without presenteeism. Workers with a precarious contract had a lower risk to report absenteeism without presenteeism and the combination of both presenteeism and absenteeism. Finally, for workers perceiving job insecurity, the risk for presenteeism without sickness absence was significantly higher. Several indicators of low employment quality were associated with attendance behavior, suggesting a complex behavioral mechanism in workers facing low job quality employment. Therefore, policy makers are recommended to re-establish the indefinite contractual employment as the standard, avoiding long working hours. © The Author 2016. Published by Oxford University Press on behalf of Faculty of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

Multihandicapped Blind. Final Project Report.

ERIC Educational Resources Information Center

Jones, Lloyd

The final report of the Garden Grove unified school district project for 1969 through 1972 (funded through Title III) involving six multiply handicapped, legally blind children, 7- to 10-years-old, who were previously excluded from special education (SE) classes is presented. Described as the main procedural objective is development of a…

Fluency and belief bias in deductive reasoning: new indices for old effects

PubMed Central

Trippas, Dries; Handley, Simon J.; Verde, Michael F.

2014-01-01

Models based on signal detection theory (SDT) have occupied a prominent role in domains such as perception, categorization, and memory. Recent work by Dube et al. (2010) suggests that the framework may also offer important insights in the domain of deductive reasoning. Belief bias in reasoning has traditionally been examined using indices based on raw endorsement rates—indices that critics have claimed are highly problematic. We discuss a new set of SDT indices fit for the investigation belief bias and apply them to new data examining the effect of perceptual disfluency on belief bias in syllogisms. In contrast to the traditional approach, the SDT indices do not violate important statistical assumptions, resulting in a decreased Type 1 error rate. Based on analyses using these novel indices we demonstrate that perceptual disfluency leads to decreased reasoning accuracy, contrary to predictions. Disfluency also appears to eliminate the typical link found between cognitive ability and the effect of beliefs on accuracy. Finally, replicating previous work, we demonstrate that cognitive ability leads to an increase in reasoning accuracy and a decrease in the response bias component of belief bias. PMID:25009515

A quantum dynamics study of the benzopyran ring opening guided by laser pulses

NASA Astrophysics Data System (ADS)

Saab, Mohamad; Doriol, Loïc Joubert; Lasorne, Benjamin; Guérin, Stéphane; Gatti, Fabien

2014-10-01

The ring-opening photoisomerization of benzopyran, which occurs via a photochemical route involving a conical intersection, has been studied with quantum dynamics calculations using the multi-configuration time-dependent Hartree method (MCTDH). We introduce a mechanistic strategy to control the conversion of benzopyran to merocyanine with laser pulses. We use a six-dimensional model developed in a previous work for the potential energy surfaces (PES) based on an extension of the vibronic-coupling Hamiltonian model (diabatization method by ansatz), which depends on the most active degrees of freedom. The main objective of these quantum dynamics simulations is to provide a set of strategies that could help experimentalists to control the photoreactivity vs. photostability ratio (selectivity). In this work we present: (i) a pump-dump technique used to control the photostability, (ii) a two-step strategy to enhance the reactivity of the system: first, a pure vibrational excitation in the electronic ground state that prepares the system and, second, an ultraviolet excitation that brings the system to the first adiabatic electronic state; (iii) finally the effect of a non-resonant pulse (Stark effect) on the dynamics.

Career histories as determinants of gendered retirement timing in the Danish and Swedish pension systems.

PubMed

König, Stefanie

2017-12-01

After reforms in pension systems had taken place in most European countries within the last two decades, the concern was raised that women may be disadvantaged by these reforms. It is suggested that they are faced with a higher financial need to work longer. Retrospective data from SHARELIFE are used to run an event history analysis on the timing of the final employment exit, separately for gender, country and exit cohort. This study aims to disentangle the influence of gendered labour markets and pension regulations on retirement timing by investigating conditions in Denmark and Sweden. Some evidence was found that women compensate for lower labour market attachment due to long part-time periods by working longer, especially in younger cohorts. This seems to depend on the pension system. In countries with broad basic pensions, high replacement rates for low-income groups and fewer penalties for early retirement, the compensation is suggested to be less frequent. This study indicates the growing importance of the "compensation hypothesis" compared to the "status maintenance hypothesis" of previous careers in relation with retirement timing.

Mechanisms linking authentic leadership to emotional exhaustion: The role of procedural justice and emotional demands in a moderated mediation approach.

PubMed

Kampa, Judith; Rigotti, Thomas; Otto, Kathleen

2017-04-07

In order to gain more knowledge on how the positive leadership concept of authentic leadership impacts follower strain, this study tries to uncover procedural justice as an underlying mechanism. In contrast to previous work, we exclusively base our theoretical model on justice theories. Specifically, we hypothesize that authentic leadership negatively predicts emotional exhaustion through perceptions of procedural justice. We assume that this indirect effect is conditional on followers' amount of emotional demands, and that the procedural justice-emotional exhaustion relationship is stronger when emotional demands are high. This finally results in a stronger exhaustion-reducing effect of authentic leadership. The proposed moderated mediation model was tested in a sample of N=628 employees nested in 168 teams using lagged data from three waves. Results provide support for all hypotheses. Authentic leadership is critical to employees' well-being as it contributes to an elevated perception of positive work conditions (procedural justice), especially in contexts with high emotional demands. Limitations and practical implications on leadership development are discussed.

Fluorescence spectroscopy as a tool for determining microbial quality in potable water applications.

PubMed

Cumberland, Susan; Bridgeman, John; Baker, Andy; Sterling, Mark; Ward, David

2012-01-01

Building on previous work where fluorescence spectroscopy has been used to detect sewage in rivers, a portable LED spectrophotometer was used for the first time to establish bacterial numbers in a range of water samples. A mixed-method approach was used with standard bacteria enumeration techniques on diluted river water and sewage works final effluent using a number of diluents (Ringer's solution, tap water and potable spring water). Fluorescence from uncultured dilutions was detected at a 280 nm excitation/360 nm emission wavelength (corresponding to the region of tryptophan and indole fluorescence) and compared with bacteria numbers on the same cultured sample. Good correlations were obtained for total coliforms, E. coli and heterotrophic bacteria with the portable LED spectrophotometer (R2 = 0.78, 0.72 and 0.81 respectively). The results indicate that the portable spectrophotometer could be applied to establish the quality of drinking water in areas of poor sanitation that are subject to faecal contamination, where infrastructure failure has occurred in the supply of clean drinking water. This would be particularly useful where laboratory facilities are not at hand.

Interacting complex systems: Theory and application to real-world situations

NASA Astrophysics Data System (ADS)

Piccinini, Nicola

The interest in complex systems has increased exponentially during the past years because it was found helpful in addressing many of today's challenges. The study of the brain, biology, earthquakes, markets and social sciences are only a few examples of the fields that have benefited from the investigation of complex systems. Internet, the increased mobility of people and the raising energy demand are among the factors that brought in contact complex systems that were isolated till a few years ago. A theory for the interaction between complex systems is becoming more and more urgent to help mankind in this transition. The present work builds upon the most recent results in this field by solving a theoretical problem that prevented previous work to be applied to important complex systems, like the brain. It also shows preliminary laboratory results of perturbation of in vitro neural networks that were done to test the theory. Finally, it gives a preview of the studies that are being done to create a theory that is even closer to the interaction between real complex systems.

Security risk assessment: applying the concepts of fuzzy logic.

PubMed

Bajpai, Shailendra; Sachdeva, Anish; Gupta, J P

2010-01-15

Chemical process industries (CPI) handling hazardous chemicals in bulk can be attractive targets for deliberate adversarial actions by terrorists, criminals and disgruntled employees. It is therefore imperative to have comprehensive security risk management programme including effective security risk assessment techniques. In an earlier work, it has been shown that security risk assessment can be done by conducting threat and vulnerability analysis or by developing Security Risk Factor Table (SRFT). HAZOP type vulnerability assessment sheets can be developed that are scenario based. In SRFT model, important security risk bearing factors such as location, ownership, visibility, inventory, etc., have been used. In this paper, the earlier developed SRFT model has been modified using the concepts of fuzzy logic. In the modified SRFT model, two linguistic fuzzy scales (three-point and four-point) are devised based on trapezoidal fuzzy numbers. Human subjectivity of different experts associated with previous SRFT model is tackled by mapping their scores to the newly devised fuzzy scale. Finally, the fuzzy score thus obtained is defuzzyfied to get the results. A test case of a refinery is used to explain the method and compared with the earlier work.

Doxorubicin hinders DNA condensation promoted by the protein bovine serum albumin (BSA).

PubMed

Lima, C H M; de Paula, H M C; da Silva, L H M; Rocha, M S

2017-12-01

In this work, we have studied the interaction between the anticancer drug doxorubicin (doxo) and condensed DNA, using optical tweezers. To perform this task, we use the protein bovine serum albumin (BSA) in the working buffer to mimic two key conditions present in the real intracellular environment: the condensed state of the DNA and the abundant presence of charged macromolecules in the surrounding medium. In particular, we have found that, when doxo is previously intercalated in disperse DNA, the drug hinders the DNA condensation process upon the addition of BSA in the buffer. On the other hand, when bare DNA is firstly condensed by BSA, doxo is capable to intercalate and to unfold the DNA condensates at relatively high concentrations. In addition, a specific interaction between BSA and doxo was verified, which significantly changes the chemical equilibrium of the DNA-doxo interaction. Finally, the presence of BSA in the buffer stabilizes the double-helix structure of the DNA-doxo complexes, preventing partial DNA denaturation induced by the stretching forces. © 2017 Wiley Periodicals, Inc.

Mechanisms linking authentic leadership to emotional exhaustion: The role of procedural justice and emotional demands in a moderated mediation approach

PubMed Central

KAMPA, Judith; RIGOTTI, Thomas; OTTO, Kathleen

2016-01-01

In order to gain more knowledge on how the positive leadership concept of authentic leadership impacts follower strain, this study tries to uncover procedural justice as an underlying mechanism. In contrast to previous work, we exclusively base our theoretical model on justice theories. Specifically, we hypothesize that authentic leadership negatively predicts emotional exhaustion through perceptions of procedural justice. We assume that this indirect effect is conditional on followers’ amount of emotional demands, and that the procedural justice-emotional exhaustion relationship is stronger when emotional demands are high. This finally results in a stronger exhaustion-reducing effect of authentic leadership. The proposed moderated mediation model was tested in a sample of N=628 employees nested in 168 teams using lagged data from three waves. Results provide support for all hypotheses. Authentic leadership is critical to employees’ well-being as it contributes to an elevated perception of positive work conditions (procedural justice), especially in contexts with high emotional demands. Limitations and practical implications on leadership development are discussed. PMID:27818452

Limit cycles and conformal invariance

NASA Astrophysics Data System (ADS)

Fortin, Jean-François; Grinstein, Benjamín; Stergiou, Andreas

2013-01-01

There is a widely held belief that conformal field theories (CFTs) require zero beta functions. Nevertheless, the work of Jack and Osborn implies that the beta functions are not actually the quantites that decide conformality, but until recently no such behavior had been exhibited. Our recent work has led to the discovery of CFTs with nonzero beta functions, more precisely CFTs that live on recurrent trajectories, e.g., limit cycles, of the beta-function vector field. To demonstrate this we study the S function of Jack and Osborn. We use Weyl consistency conditions to show that it vanishes at fixed points and agrees with the generator Q of limit cycles on them. Moreover, we compute S to third order in perturbation theory, and explicitly verify that it agrees with our previous determinations of Q. A byproduct of our analysis is that, in perturbation theory, unitarity and scale invariance imply conformal invariance in four-dimensional quantum field theories. Finally, we study some properties of these new, "cyclic" CFTs, and point out that the a-theorem still governs the asymptotic behavior of renormalization-group flows.

Scale up of NiTi shape memory alloy production by EBM

NASA Astrophysics Data System (ADS)

Otubo, J.; Rigo, O. D.; Moura Neto, C.; Kaufman, M. J.; Mei, P. R.

2003-10-01

The usual process to produce NiTi shape memory alloy is by vacuum induction melting (VIM) using a graphite crucible, which causes contamination of the melt with carbon. Contamination with oxygen originates from the residual oxygen inside the melting chamber. An alternative process to produce NiTi alloys is by electron beam melting (EBM) using a water-cooled copper crucible that eliminates carbon contamination, and the oxygen contamination would be minimal due to operation in a vacuum of better than 10^{-2} Pa. In a previous work, it was demonstrated that the technique is feasible for button shaped samples weighing around 30g. The present work presents the results on the scale up program that enables the production of larger samples/ingots. The results are very promising in terms of chemical composition homogeneity as well as in terms of carbon contamination, the latter being four to ten times lower than the commercially-produced VIM products, and in terms of final oxygen content which is shown to depend primarily on the starting raw materials.

Measure Guideline: Guide to Attic Air Sealing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lstiburek, J.

2014-09-01

The Guide to Attic Air Sealing was completed in 2010 and although not in the standard Measure Guideline format, is intended to be a Measure Guideline on Attic Air Sealing. The guide was reviewed during two industry stakeholders meetings held on December 18th, 2009 and January 15th, 2010, and modified based on the comments received. Please do not make comments on the Building America format of this document. The purpose of the Guide to Attic Air Sealing is to provide information and recommendations for the preparation work necessary prior to adding attic insulation. Even though the purpose of this guidemore » is to save energy - health, safety and durability should not be compromised by energy efficiency. Accordingly, combustion safety and ventilation for indoor air quality are addressed first. Durability and attic ventilation then follow. Finally, to maximize energy savings, air sealing is completed prior to insulating. The guide is intended for home remodelers, builders, insulation contractors, mechanical contractors, general contractors who have previously done remodeling and homeowners as a guide to the work that needs to be done.« less

Handedness differences in information framing.

PubMed

Jasper, John D; Fournier, Candice; Christman, Stephen D

2014-02-01

Previous research has shown that strength of handedness predicts differences in sensory illusions, Stroop interference, episodic memory, and beliefs about body image. Recent evidence also suggests handedness differences in the susceptibility to common decision biases such as anchoring and sunk cost. The present paper extends this line of work to attribute framing effects. Sixty-three undergraduates were asked to advise a friend concerning the use of a safe allergy medication during pregnancy. A third of the participants received negatively-framed information concerning the fetal risk of the drug (1-3% chance of having a malformed child); another third received positively-framed information (97-99% chance of having a normal child); and the final third received no counseling information and served as the control. Results indicated that, as predicted, inconsistent (mixed)-handers were more responsive than consistent (strong)-handers to information changes and readily update their beliefs. Although not significant, the data also suggested that only inconsistent handers were affected by information framing. Theoretical implications as well as ongoing work in holistic versus analytic processing, contextual sensitivity, and brain asymmetry will be discussed. Copyright © 2013 Elsevier Inc. All rights reserved.

Whither cognitive bias modification research? Commentary on the special section articles.

PubMed

MacLeod, Colin; Koster, Ernst H W; Fox, Elaine

2009-02-01

This commentary reviews key theoretical, methodological, and clinical issues raised by recent research on cognitive bias modification (CBM). The authors identify the major ways in which the new work reported within this special section extends earlier CBM research. In particular, they note that it considers a wider range of participants, includes a greater diversity of symptoms measures, and targets for change a broader array of processing biases than previously has been the case. Furthermore, they point out that the present work develops and employs a more diverse arsenal of bias modification procedures, in some cases delivered across extended periods of time within naturalistic settings. They also draw attention to methodological limitations associated with the current studies, offering recommendations concerning how future CBM research might profitably build upon these exciting new directions while overcoming such limitations. Finally, they evaluate the theoretical and applied implications of the reported findings, discussing their capacity to illuminate the causal contributions made by cognitive bias to emotional vulnerability and their promise concerning the potential therapeutic value of CBM as a clinical tool.

New hesitation-based distance and similarity measures on intuitionistic fuzzy sets and their applications

NASA Astrophysics Data System (ADS)

Kang, Yun; Wu, Shunxiang; Cao, Da; Weng, Wei

2018-03-01

In this paper, we present new definitions on distance and similarity measures between intuitionistic fuzzy sets (IFSs) by combining with hesitation degree. First, we discuss the limitations in traditional distance and similarity measures, which are caused by the neglect of hesitation degree's influence. Even though a vector-valued similarity measure was proposed, which has two components indicating similarity and hesitation aspects, it still cannot perform well in practical applications because hesitation works only when the values of similarity measures are equal. In order to overcome the limitations, we propose new definitions on hesitation, distance and similarity measures, and research some theorems which satisfy the requirements of the proposed definitions. Meanwhile, we investigate the relationships among hesitation, distance, similarity and entropy of IFSs to verify the consistency of our work and previous research. Finally, we analyse and discuss the advantages and disadvantages of the proposed similarity measure in detail, and then we apply the proposed measures (dH and SH) to deal with pattern recognition problems, and demonstrate that they outperform state-of-the-art distance and similarity measures.

Paint and Click: Unified Interactions for Image Boundaries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Summa, B.; Gooch, A. A.; Scorzelli, G.

Image boundaries are a fundamental component of many interactive digital photography techniques, enabling applications such as segmentation, panoramas, and seamless image composition. Interactions for image boundaries often rely on two complementary but separate approaches: editing via painting or clicking constraints. In this work, we provide a novel, unified approach for interactive editing of pairwise image boundaries that combines the ease of painting with the direct control of constraints. Rather than a sequential coupling, this new formulation allows full use of both interactions simultaneously, giving users unprecedented flexibility for fast boundary editing. To enable this new approach, we provide technical advancements.more » In particular, we detail a reformulation of image boundaries as a problem of finding cycles, expanding and correcting limitations of the previous work. Our new formulation provides boundary solutions for painted regions with performance on par with state-of-the-art specialized, paint-only techniques. In addition, we provide instantaneous exploration of the boundary solution space with user constraints. Finally, we provide examples of common graphics applications impacted by our new approach.« less

Effective field theory of dissipative fluids (II): classical limit, dynamical KMS symmetry and entropy current

DOE Office of Scientific and Technical Information (OSTI.GOV)

Glorioso, Paolo; Crossley, Michael; Liu, Hong

2017-09-20

Here in this paper we further develop the fluctuating hydrodynamics proposed in a number of ways. We first work out in detail the classical limit of the hydrodynamical action, which exhibits many simplifications. In particular, this enables a transparent formulation of the action in physical spacetime in the presence of arbitrary external fields. It also helps to clarify issues related to field redefinitions and frame choices. We then propose that the action is invariant under a Z2 symmetry to which we refer as the dynamical KMS symmetry. The dynamical KMS symmetry is physically equivalent to the previously proposed local KMSmore » condition in the classical limit, but is more convenient to implement and more general. It is applicable to any states in local equilibrium rather than just thermal density matrix perturbed by external background fields. Finally we elaborate the formulation for a conformal fluid, which contains some new features, and work out the explicit form of the entropy current to second order in derivatives for a neutral conformal fluid.« less

Teaching Resistance through an interactive gaming lab

NASA Astrophysics Data System (ADS)

O'Brien, James G.; Sirokman, Greg; Rueckert, Franz; Cascio, Derek

2015-04-01

The use of gaming as an educational tool has proven to be an effective paradigm in modern pedagogy. Following the success of their previous work ``Sector Vector,'' the authors present a new interactive game-based laboratory to highlight the basic manipulation and calculation of resistors in circuits. ``Resistance is Futile'' delivers the lesson of basic resistor combinations in a game based exercise where teams build a continually evolving circuit. As the game progresses, students must develop long and short term plans to modify an ever-changing circuit and meet primary and secondary objectives. Each turn requires quick calculations of resistor combinations and the assessment of future options. Students are also exposed to the creation of a modular circuit, which may not conform to standard textbook examples. To determine a winner, the students work together to analyze and evaluate a potentially complex final circuit diagram. The dynamic atmosphere and competitive nature established by the gaming environment have been shown to increase student engagement and concept retention. In this presentation, we will discuss both the structure of the lab-based game and the pedagogical implications this implementation versus the traditional resistor combination laboratory exercise.

HiTAD: detecting the structural and functional hierarchies of topologically associating domains from chromatin interactions

PubMed Central

Wang, Xiao-Tao; Cui, Wang

2017-01-01

Abstract A current question in the high-order organization of chromatin is whether topologically associating domains (TADs) are distinct from other hierarchical chromatin domains. However, due to the unclear TAD definition in tradition, the structural and functional uniqueness of TAD is not well studied. In this work, we refined TAD definition by further constraining TADs to the optimal separation on global intra-chromosomal interactions. Inspired by this constraint, we developed a novel method, called HiTAD, to detect hierarchical TADs from Hi-C chromatin interactions. HiTAD performs well in domain sensitivity, replicate reproducibility and inter cell-type conservation. With a novel domain-based alignment proposed by us, we defined several types of hierarchical TAD changes which were not systematically studied previously, and subsequently used them to reveal that TADs and sub-TADs differed statistically in correlating chromosomal compartment, replication timing and gene transcription. Finally, our work also has the implication that the refinement of TAD definition could be achieved by only utilizing chromatin interactions, at least in part. HiTAD is freely available online. PMID:28977529