Incorporating temporal and clinical reasoning in a new measure of continuity of care.
Spooner, S. A.
1994-01-01
Previously described quantitative methods for measuring continuity of care have assumed that perfect continuity exists when a patient sees only one provider, regardless of the temporal pattern and clinical context of the visits. This paper describes an implementation of a new operational model of continuity--the Temporal Continuity Index--that takes into account time intervals between well visits in a pediatric residency continuity clinic. Ideal continuity in this model is achieved when intervals between visits are appropriate based on the age of the patient and clinical context of the encounters. The fundamental concept in this model is the expectation interval, which contains the length of the maximum ideal follow-up interval for a visit and the maximum follow-up interval. This paper describes an initial implementation of the TCI model and compares TCI calculations to previous quantitative methods and proposes its use as part of the assessment of resident education in outpatient settings. PMID:7950019
[Does the right to die with dignity exist?].
Toro Flores, Rafael
2008-12-01
Death is one of the few certainties in human beings. This reality generates uneasiness regarding how death will occur especially in circumstances of loneliness or suffering which can become agony. In this report, the author first analyzes the existence of the right to die with dignity as a human right which takes on the nature of being a subjective right. In continuation, the author describes the existing problematic in the application of this right to die in relationship to the so-called double effect mechanism and euthanasia. The author concludes this article by proposing previous instructions or anticipated desires as ideal measures to make the right to die with dignity valid.
A stage structure pest management model with impulsive state feedback control
NASA Astrophysics Data System (ADS)
Pang, Guoping; Chen, Lansun; Xu, Weijian; Fu, Gang
2015-06-01
A stage structure pest management model with impulsive state feedback control is investigated. We get the sufficient condition for the existence of the order-1 periodic solution by differential equation geometry theory and successor function. Further, we obtain a new judgement method for the stability of the order-1 periodic solution of the semi-continuous systems by referencing the stability analysis for limit cycles of continuous systems, which is different from the previous method of analog of Poincarè criterion. Finally, we analyze numerically the theoretical results obtained.
Inoue, Kazuya; Takeda, Yuji; Kimura, Motohiro
2017-02-01
In a task involving continuous action to achieve a goal, the sense of agency increases with an improvement in task performance that is induced by unnoticed computer assistance. This study investigated how explicit instruction about the existence of computer assistance affects the increase of sense of agency that accompanies performance improvement. Participants performed a continuous action task in which they controlled the direction of motion of a dot to a goal by pressing keys. When instructions indicated the absence of assistance, the sense of agency increased with performance improvement induced by computer assistance, replicating previous findings. Interestingly, this increase of sense of agency was also observed even when instructions indicated the presence of assistance. These results suggest that even when a plausible cause of performance improvement other than one's own action exists, the improvement can be misattributed to one's own control of action, resulting in an increased sense of agency. Copyright © 2016 Elsevier Inc. All rights reserved.
Magnetoacoustic Sensing of Magnetic Nanoparticles.
Kellnberger, Stephan; Rosenthal, Amir; Myklatun, Ahne; Westmeyer, Gil G; Sergiadis, George; Ntziachristos, Vasilis
2016-03-11
The interaction of magnetic nanoparticles and electromagnetic fields can be determined through electrical signal induction in coils due to magnetization. However, the direct measurement of instant electromagnetic energy absorption by magnetic nanoparticles, as it relates to particle characterization or magnetic hyperthermia studies, has not been possible so far. We introduce the theory of magnetoacoustics, predicting the existence of second harmonic pressure waves from magnetic nanoparticles due to energy absorption from continuously modulated alternating magnetic fields. We then describe the first magnetoacoustic system reported, based on a fiber-interferometer pressure detector, necessary for avoiding electric interference. The magnetoacoustic system confirmed the existence of previously unobserved second harmonic magnetoacoustic responses from solids, magnetic nanoparticles, and nanoparticle-loaded cells, exposed to continuous wave magnetic fields at different frequencies. We discuss how magnetoacoustic signals can be employed as a nanoparticle or magnetic field sensor for biomedical and environmental applications.
Is Risky Sexual Behavior Continuous or Categorical? A Taxometric Analysis of the Sexual Risk Survey
ERIC Educational Resources Information Center
Marcus, David K.; Fulton, Jessica J.; Turchik, Jessica A.
2011-01-01
Risky sexual behaviors are behaviors that involve the possibility of an adverse outcome, such as contracting a sexually transmitted infection or unwanted pregnancy. The question of whether risky sexual behavior exists as a discrete class (i.e., taxon) or as a dimensional construct has not previously been explored. The authors performed a set of…
Does Forest Continuity Enhance the Resilience of Trees to Environmental Change?
von Oheimb, Goddert; Härdtle, Werner; Eckstein, Dieter; Engelke, Hans-Hermann; Hehnke, Timo; Wagner, Bettina; Fichtner, Andreas
2014-01-01
There is ample evidence that continuously existing forests and afforestations on previously agricultural land differ with regard to ecosystem functions and services such as carbon sequestration, nutrient cycling and biodiversity. However, no studies have so far been conducted on possible long-term (>100 years) impacts on tree growth caused by differences in the ecological continuity of forest stands. In the present study we analysed the variation in tree-ring width of sessile oak (Quercus petraea (Matt.) Liebl.) trees (mean age 115-136 years) due to different land-use histories (continuously existing forests, afforestations both on arable land and on heathland). We also analysed the relation of growth patterns to soil nutrient stores and to climatic parameters (temperature, precipitation). Tree rings formed between 1896 and 2005 were widest in trees afforested on arable land. This can be attributed to higher nitrogen and phosphorous availability and indicates that former fertilisation may continue to affect the nutritional status of forest soils for more than one century after those activities have ceased. Moreover, these trees responded more strongly to environmental changes - as shown by a higher mean sensitivity of the tree-ring widths - than trees of continuously existing forests. However, the impact of climatic parameters on the variability in tree-ring width was generally small, but trees on former arable land showed the highest susceptibility to annually changing climatic conditions. We assume that incompletely developed humus horizons as well as differences in the edaphon are responsible for the more sensitive response of oak trees of recent forests (former arable land and former heathland) to variation in environmental conditions. We conclude that forests characterised by a long ecological continuity may be better adapted to global change than recent forest ecosystems.
Does Forest Continuity Enhance the Resilience of Trees to Environmental Change?
von Oheimb, Goddert; Härdtle, Werner; Eckstein, Dieter; Engelke, Hans-Hermann; Hehnke, Timo; Wagner, Bettina; Fichtner, Andreas
2014-01-01
There is ample evidence that continuously existing forests and afforestations on previously agricultural land differ with regard to ecosystem functions and services such as carbon sequestration, nutrient cycling and biodiversity. However, no studies have so far been conducted on possible long-term (>100 years) impacts on tree growth caused by differences in the ecological continuity of forest stands. In the present study we analysed the variation in tree-ring width of sessile oak (Quercus petraea (Matt.) Liebl.) trees (mean age 115–136 years) due to different land-use histories (continuously existing forests, afforestations both on arable land and on heathland). We also analysed the relation of growth patterns to soil nutrient stores and to climatic parameters (temperature, precipitation). Tree rings formed between 1896 and 2005 were widest in trees afforested on arable land. This can be attributed to higher nitrogen and phosphorous availability and indicates that former fertilisation may continue to affect the nutritional status of forest soils for more than one century after those activities have ceased. Moreover, these trees responded more strongly to environmental changes – as shown by a higher mean sensitivity of the tree-ring widths – than trees of continuously existing forests. However, the impact of climatic parameters on the variability in tree-ring width was generally small, but trees on former arable land showed the highest susceptibility to annually changing climatic conditions. We assume that incompletely developed humus horizons as well as differences in the edaphon are responsible for the more sensitive response of oak trees of recent forests (former arable land and former heathland) to variation in environmental conditions. We conclude that forests characterised by a long ecological continuity may be better adapted to global change than recent forest ecosystems. PMID:25494042
ECS: efficient communication scheduling for underwater sensor networks.
Hong, Lu; Hong, Feng; Guo, Zhongwen; Li, Zhengbao
2011-01-01
TDMA protocols have attracted a lot of attention for underwater acoustic sensor networks (UWSNs), because of the unique characteristics of acoustic signal propagation such as great energy consumption in transmission, long propagation delay and long communication range. Previous TDMA protocols all allocated transmission time to nodes based on discrete time slots. This paper proposes an efficient continuous time scheduling TDMA protocol (ECS) for UWSNs, including the continuous time based and sender oriented conflict analysis model, the transmission moment allocation algorithm and the distributed topology maintenance algorithm. Simulation results confirm that ECS improves network throughput by 20% on average, compared to existing MAC protocols.
Periodicity in Age-Resolved Populations
NASA Astrophysics Data System (ADS)
Esipov, Sergei
We discuss the interplay between the non-linear diffusion and age-resolved population dynamics. Depending on the age properties of collective migration the system may exhibit continuous joint expansion of all ages or continuous expansion with age segregation. Between these two obvious limiting regimes there is an interesting window of periodic expansion, which has been previously used by us in modeling bacterial colonies of Proteus mirabilis. In order to test whether the age-dependent collective migration leads to periodicity in other systems we performed a Fourier analysis of historical data on ethnic expansions and found multiple co-existing periods of activity.
Detecting perceptual groupings in textures by continuity considerations
NASA Technical Reports Server (NTRS)
Greene, Richard J.
1990-01-01
A generalization is presented for the second derivative of a Gaussian D(sup 2)G operator to apply to problems of perceptual organization involving textures. Extensions to other problems of perceptual organization are evident and a new research direction can be established. The technique presented is theoretically pleasing since it has the potential of unifying the entire area of image segmentation under the mathematical notion of continuity and presents a single algorithm to form perceptual groupings where many algorithms existed previously. The eventual impact on both the approach and technique of image processing segmentation operations could be significant.
Impact of integrated programs on general surgery operative volume.
Jensen, Amanda R; Nickel, Brianne L; Dolejs, Scott C; Canal, David F; Torbeck, Laura; Choi, Jennifer N
2017-03-01
Integrated residencies are now commonplace, co-existing with categorical general surgery residencies. The purpose of this study was to define the impact of integrated programs on categorical general surgery operative volume. Case logs from categorical general, integrated plastics, vascular, and thoracic surgery residents from a single institution from 2008 to 2016 were collected and analyzed. Integrated residents have increased the number of cases they perform that would have previously been general surgery resident cases from 11 in 2009-2010 to 1392 in 2015-2016. Despite this, there was no detrimental effect on total major cases of graduating chief residents. Multiple integrated programs can co-exist with a general surgery program through careful collaboration and thoughtful consideration to longitudinal needs of individual trainees. As additional programs continue to be created, both integrated and categorical program directors must continue to collaborate to insure the integrity of training for all residents. Copyright © 2017 Elsevier Inc. All rights reserved.
Alesi, Patrick
2008-04-01
This paper follows the development of the business continuity planning (BCP) programme at Lehman Brothers following the events of September 11th. Previous attempts to implement a `traditional' form of BCP had been ineffective, but following the events, the firm began to look at BCP in a new light. This paper deals with three main themes: creating a culture of resiliency, leveraging technology, and building flexible plans. Distributing accountability for BCP to business line managers, integrating BCP change management into the normal course of business, and providing every employee with personalised BCP information breeds a culture of resiliency where people are empowered to react to events without burdensome, hierarchical response and recovery procedures. Building a strong relationship with one's application development community can result in novel, customised BCP solutions; existing systems and data structures can be used to enhance an existing BCP. Even the best plans are often challenged by events; understanding that flexibility is essential to effective incident response is a critical element in the development of a proper business continuity plan.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Houston, J.R.; Blumer, P.J.
1979-03-01
Environmental data collected during 1978 in the vicinity of the Marine Research Laboratory show continued compliance with all applicable state and federal regulations and furthermore show no detectable change from conditions that existed in previous years. Samples collected for radiological analysis included soil, drinking water, bay water, clams, and seaweed. Radiation dose rates at 1 meter aboveground were also measured.
ECS: Efficient Communication Scheduling for Underwater Sensor Networks
Hong, Lu; Hong, Feng; Guo, Zhongwen; Li, Zhengbao
2011-01-01
TDMA protocols have attracted a lot of attention for underwater acoustic sensor networks (UWSNs), because of the unique characteristics of acoustic signal propagation such as great energy consumption in transmission, long propagation delay and long communication range. Previous TDMA protocols all allocated transmission time to nodes based on discrete time slots. This paper proposes an efficient continuous time scheduling TDMA protocol (ECS) for UWSNs, including the continuous time based and sender oriented conflict analysis model, the transmission moment allocation algorithm and the distributed topology maintenance algorithm. Simulation results confirm that ECS improves network throughput by 20% on average, compared to existing MAC protocols. PMID:22163775
Sommer, Gregory J.; Hatch, Anson V.; Singh, Anup K.; Wang, Ying-Chih
2012-12-11
Disclosed is a novel microfluidic device enabling on-chip implementation of a two-dimensional separation methodology. Previously disclosed microscale immobilized pH gradients (IPG) are combined with perpendicular polyacrylamide gel electrophoresis (PAGE) microchannels to achieve orthogonal separations of biological samples. Device modifications enable inclusion of sodium dodecyl sulfate (SDS) in the second dimension. The device can be fabricated to use either continuous IPG gels, or the microscale isoelectric fractionation membranes we have also previously disclosed, for the first dimension. The invention represents the first all-gel two-dimensional separation microdevice, with significantly higher resolution power over existing devices.
Sommer, Gregory J; Hatch, Anson V; Singh, Anup K; Wang, Ying-Chih
2014-05-20
Disclosed is a novel microfluidic device enabling on-chip implementation of a two-dimensional separation methodology. Previously disclosed microscale immobilized pH gradients (IPG) are combined with perpendicular polyacrylamide gel electrophoresis (PAGE) microchannels to achieve orthogonal separations of biological samples. Device modifications enable inclusion of sodium dodecyl sulfate (SDS) in the second dimension. The device can be fabricated to use either continuous IPG gels, or the microscale isoelectric fractionation membranes we have also previously disclosed, for the first dimension. The invention represents the first all-gel two-dimensional separation microdevice, with significantly higher resolution power over existing devices.
Integrating Existing Simulation Components into a Cohesive Simulation System
NASA Technical Reports Server (NTRS)
McLaughlin, Brian J.; Barrett, Larry K.
2012-01-01
A tradition of leveraging the re-use of components to help manage costs has evolved in the development of complex system. This tradition continues on in the Joint Polar Satellite System (JPSS) Program with the cloning of the Suomi National Polar-orbiting Partnership (NPP) satellite for the JPSS-1 mission, including the instrument complement. One benefit of re-use on a mission is the availability of existing simulation assets from the systems that were previously built. An issue arises in the continual shift of technology over a long mission, or multi-mission, lifecycle. As the missions mature, the requirements for the observatory simulations evolve. The challenge in this environment becomes re-using the existing components in that ever-changing landscape. To meet this challenge, the system must: establish an operational architecture that minimizes impacts on the implementation of individual components, consolidate the satisfaction of new high-impact requirements into system-level infrastructure, and build in a long-term view of system adaptation that spans the full lifecycle of the simulation system. The Flight Vehicle Test Suite (FVTS) within the JPSS Program is defining and executing this approach to ensure a robust simulation capability for the JPSS multi-mission environment
Su, Tsann-Juu; Tzeng, Ya-Ling; Kuo, Pi-Chao
2011-08-01
To compare the anxiety levels of Taiwanese women who continued with in vitro fertilisation treatment and those who discontinued treatment post-in vitro fertilisation failure. In vitro fertilisation is perceived as the last resort of infertility treatment. The impact of unsuccessful in vitro fertilisation treatment on psychological function has been documented; however, research comparing the levels of anxiety of women who cease and those who continue in vitro fertilisation post-failure is scant. A cross-sectional comparative study design was used. Fifty-eight women in whom in vitro fertilisation had failed within the previous year were recruited to this study from a medical centre in northern Taiwan; 34 women continued treatment and 24 discontinued treatment. The State-Trait Anxiety Inventory was used to assess their levels of anxiety. Women in the group who continued treatment exhibited higher state and trait anxiety (TA) than women in the group who discontinued treatment (p < 0·005). The number and frequency of in vitro fertilisation cycles were significantly higher in the group who continued treatment than in those who did not. A strong positive correlation between state and TA (r = 0·8, p < 0·01) existed in both groups. Both groups exhibited considerable levels of anxiety; however, the women who continued in vitro fertilisation treatment had higher levels of anxiety than those who discontinued treatment. The level of anxiety of women who decide to continue in vitro fertilisation treatment should be assessed as early as possible and counselling services provided to women who experience in vitro fertilisation failure should concentrate more on relieving psychological distress. One year after discontinuing treatment, some women still experience considerable anxiety; therefore, the care and assistance provided to these women need to be continually evaluated. © 2011 Blackwell Publishing Ltd.
Monostatic lidar in weak-to-strong turbulence
NASA Astrophysics Data System (ADS)
Andrews, L. C.; Phillips, R. L.
2001-07-01
A heuristic scintillation model previously developed for weak-to-strong irradiance fluctuations of a spherical wave is extended in this paper to the case of a monostatic lidar configuration. As in the previous model, we account for the loss of spatial coherence as the optical wave propagates through atmospheric turbulence by eliminating the effects of certain turbulent scale sizes that exist between the scale size of the spatial coherence radius of the beam and that of the scattering disc. These mid-range scale-size effects are eliminated through the formal introduction of spatial scale frequency filters that continually adjust spatial cut-off frequencies as the optical wave propagates. In addition, we also account for correlations that exist in the incident wave to the target and the echo wave from the target arising from double-pass propagation through the same random inhomogeneities of the atmosphere. We separately consider the case of a point target and a diffuse target, concentrating on both the enhanced backscatter effect in the mean irradiance and the increase in scintillation in a monostatic channel. Under weak and strong irradiance fluctuations our asymptotic expressions are in agreement with previously published asymptotic results.
NASA Astrophysics Data System (ADS)
Arik, Sabri
2006-02-01
This Letter presents a sufficient condition for the existence, uniqueness and global asymptotic stability of the equilibrium point for bidirectional associative memory (BAM) neural networks with distributed time delays. The results impose constraint conditions on the network parameters of neural system independently of the delay parameter, and they are applicable to all bounded continuous non-monotonic neuron activation functions. The results are also compared with the previous results derived in the literature.
Toward a Superior Promotion System
2012-08-01
AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Air Force Research Institute (AFRI...Air & Space Power Journal,155 N Twining Street,Maxwell AFB,AL,36112 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME...this lan guage might have arisen to remedy a problem in this or previous evalua tion systems and has continued to exist as a vestigial feature. The
NASA Astrophysics Data System (ADS)
Mathieu, P.; Piatnitski, A.
2018-04-01
Prolongating our previous paper on the Einstein relation, we study the motion of a particle diffusing in a random reversible environment when subject to a small external forcing. In order to describe the long time behavior of the particle, we introduce the notions of steady state and weak steady state. We establish the continuity of weak steady states for an ergodic and uniformly elliptic environment. When the environment has finite range of dependence, we prove the existence of the steady state and weak steady state and compute its derivative at a vanishing force. Thus we obtain a complete `fluctuation-dissipation Theorem' in this context as well as the continuity of the effective variance.
Towards tunable and multifunctional interfaces: Multicomponent amorphous alloys and bilayer stacks
NASA Astrophysics Data System (ADS)
Kast, Matthew G.
Controlling the electronic structure and requisite charge transfer at and across interfaces is a grand challenge of materials science. Despite decades of research and numerous successes in the fields microelectronics and photovoltaics much work remains to be done. In many applications, whether they be in microelectronics, photovoltaics or display technology there is a demand for multiple functions at a single interface. Historically, existent materials were either discarded as an option due to known properties or tested with some application based figure of merit in mind. Following this, the quality of the material and/or the preparation of the surface/interface to which the material would be deposited was optimized. As the microelectronics and photovoltaics industries have matured, continued progress (faster, lower power transistors and more efficient, cheaper, abundant solar cells) will require new materials (possibly not previously existent) that are fundamentally better for their application than their highly optimized existent counter parts. The manifestation of this has been seen in the microelectronics field with introduction of hafnium silicates to replace silica (which had previously been monumentally successful) as the gate dielectrics for the most advanced transistors. Continued progress in efficient, cheap, abundant photovoltaics will require similar advances. Advances will be needed in the area of new abundant absorbers that can be deposited cheaply which result in materials with high efficiencies. In addition, selective contacts capable of extracting charge from efficient absorbers with low ohmic losses and low recombination rates will be needed. Presented here are two approaches to the multifunctional interface problem, first the use of amorphous alloys that open up the accessible composition space of thin films significantly and second the use of bilayers that loosen the requirements of a single film at an interface.
NASA Astrophysics Data System (ADS)
Feehan, Paul M. N.
2017-09-01
We prove existence of solutions to boundary value problems and obstacle problems for degenerate-elliptic, linear, second-order partial differential operators with partial Dirichlet boundary conditions using a new version of the Perron method. The elliptic operators considered have a degeneracy along a portion of the domain boundary which is similar to the degeneracy of a model linear operator identified by Daskalopoulos and Hamilton [9] in their study of the porous medium equation or the degeneracy of the Heston operator [21] in mathematical finance. Existence of a solution to the partial Dirichlet problem on a half-ball, where the operator becomes degenerate on the flat boundary and a Dirichlet condition is only imposed on the spherical boundary, provides the key additional ingredient required for our Perron method. Surprisingly, proving existence of a solution to this partial Dirichlet problem with ;mixed; boundary conditions on a half-ball is more challenging than one might expect. Due to the difficulty in developing a global Schauder estimate and due to compatibility conditions arising where the ;degenerate; and ;non-degenerate boundaries; touch, one cannot directly apply the continuity or approximate solution methods. However, in dimension two, there is a holomorphic map from the half-disk onto the infinite strip in the complex plane and one can extend this definition to higher dimensions to give a diffeomorphism from the half-ball onto the infinite ;slab;. The solution to the partial Dirichlet problem on the half-ball can thus be converted to a partial Dirichlet problem on the slab, albeit for an operator which now has exponentially growing coefficients. The required Schauder regularity theory and existence of a solution to the partial Dirichlet problem on the slab can nevertheless be obtained using previous work of the author and C. Pop [16]. Our Perron method relies on weak and strong maximum principles for degenerate-elliptic operators, concepts of continuous subsolutions and supersolutions for boundary value and obstacle problems for degenerate-elliptic operators, and maximum and comparison principle estimates previously developed by the author [13].
Senan, Sibel; Arik, Sabri
2007-10-01
This correspondence presents a sufficient condition for the existence, uniqueness, and global robust asymptotic stability of the equilibrium point for bidirectional associative memory neural networks with discrete time delays. The results impose constraint conditions on the network parameters of the neural system independently of the delay parameter, and they are applicable to all bounded continuous nonmonotonic neuron activation functions. Some numerical examples are given to compare our results with the previous robust stability results derived in the literature.
NASA Astrophysics Data System (ADS)
Kehrl, Laura; Conway, Howard; Holschuh, Nicholas; Campbell, Seth; Kurbatov, Andrei V.; Spaulding, Nicole E.
2018-05-01
The current ice core record extends back 800,000 years. Geologic and glaciological evidence suggests that the Allan Hills Blue Ice Area, East Antarctica, may preserve a continuous record that extends further back in time. In this study, we use ice-penetrating radar and existing age constraints to map the internal stratigraphy and age structure of the Allan Hills Main Ice Field. The dated isochrones provide constraints for an ice flow model to estimate the age of ice near the bed. Previous drilling in the region recovered stratigraphically disturbed sections of ice up to 2.7 million years old. Our study identifies a site 5 km upstream, which likely preserves a continuous record through Marine Isotope Stage 11 with the possibility that the record extends back 1 million years. Such records would provide new insight into the past climate and glacial history of the Ross Sea Sector.
Effects of a spin-flavour-dependent interaction on light-flavoured baryon helicity amplitudes
NASA Astrophysics Data System (ADS)
Ronniger, Michael; Metsch, Bernard Ch.
2013-01-01
This paper is a continuation of a previous work about the effects of a phenomenological flavour-dependent force in a relativistically covariant constituent quark model based on the Salpeter equation on the structure of light-flavoured baryon resonances. Here the longitudinal and transverse helicity amplitudes as studied experimentally in the electro-excitation of nucleon- and Δ-resonances are calculated. In particular the amplitudes for the excitation of three- and four-star resonances as calculated in a previous model A are compared to those of the novel model C as well as to existing and partially new experimental data such as, e.g., determined by the CB-ELSA Collaboration. A brief discussion on some improvements to model C is given after the introduction.
Continuous formation of N-chloro-N,N-dialkylamine solutions in well-mixed meso-scale flow reactors
Jolley, Katherine E
2015-01-01
Summary The continuous flow synthesis of a range of organic solutions of N,N-dialkyl-N-chloramines is described using either a bespoke meso-scale tubular reactor with static mixers or a continuous stirred tank reactor. Both reactors promote the efficient mixing of a biphasic solution of N,N-dialkylamine in organic solvent, and aqueous sodium hypochlorite to achieve near quantitative conversions, in 72–100% in situ yields, and useful productivities of around 0.05 mol/h with residence times from 3 to 20 minutes. Initial calorimetric studies have been carried out to inform on reaction exotherms, rates and safe operation. Amines which partition mainly in the organic phase require longer reaction times, provided by the CSTR, to compensate for low mass transfer rates in the biphasic system. The green metrics of the reaction have been assessed and compared to existing procedures and have shown the continuous process is improved over previous procedures. The organic solutions of N,N-dialkyl-N-chloramines produced continuously will enable their use in tandem flow reactions with a range of nucleophilic substrates. PMID:26734089
On Discontinuous Piecewise Linear Models for Memristor Oscillators
NASA Astrophysics Data System (ADS)
Amador, Andrés; Freire, Emilio; Ponce, Enrique; Ros, Javier
2017-06-01
In this paper, we provide for the first time rigorous mathematical results regarding the rich dynamics of piecewise linear memristor oscillators. In particular, for each nonlinear oscillator given in [Itoh & Chua, 2008], we show the existence of an infinite family of invariant manifolds and that the dynamics on such manifolds can be modeled without resorting to discontinuous models. Our approach provides topologically equivalent continuous models with one dimension less but with one extra parameter associated to the initial conditions. It is possible to justify the periodic behavior exhibited by three-dimensional memristor oscillators, by taking advantage of known results for planar continuous piecewise linear systems. The analysis developed not only confirms the numerical results contained in previous works [Messias et al., 2010; Scarabello & Messias, 2014] but also goes much further by showing the existence of closed surfaces in the state space which are foliated by periodic orbits. The important role of initial conditions that justify the infinite number of periodic orbits exhibited by these models, is stressed. The possibility of unsuspected bistable regimes under specific configurations of parameters is also emphasized.
Petrungaro, Paul S; Gonzalez, Santiago; Villegas, Carlos
2018-02-01
As dental implants become more popular for the treatment of partial and total edentulism and treatment of "terminal dentitions," techniques for the management of the atrophic posterior maxillae continue to evolve. Although dental implants carry a high success rate long term, attention must be given to the growing numbers of revisions or retreatment of cases that have had previous dental implant treatment and/or advanced bone replacement procedures that, due to either poor patient compliance, iatrogenic error, or poor quality of the pre-existing alveolar and/or soft tissues, have led to large osseous defects, possibly with deficient soft-tissue volume. In the posterior maxillae, where the poorest quality of bone in the oral cavity exists, achieving regeneration of the alveolar bone and adequate volume of soft tissue remains a complex procedure. This is made even more difficult when dealing with loss of dental implants previously placed, aggressive bone reduction required in various implant procedures, and/or residual sinus infections precluding proper closure of the oral wound margins. The purpose of this article is to outline a technique for the total closure of large oro-antral communications, with underlying osseous defects greater than 15 mm in width and 30 mm in length, for which multiple previous attempts at closure had failed, to achieve not only the reconstruction of adequate volume and quality of soft tissues in the area of the previous fistula, but also total regeneration of the osseous structures in the area of the large void.
Right Limits and Reflectionless Measures for CMV Matrices
NASA Astrophysics Data System (ADS)
Breuer, Jonathan; Ryckman, Eric; Zinchenko, Maxim
2009-11-01
We study CMV matrices by focusing on their right-limit sets. We prove a CMV version of a recent result of Remling dealing with the implications of the existence of absolutely continuous spectrum, and we study some of its consequences. We further demonstrate the usefulness of right limits in the study of weak asymptotic convergence of spectral measures and ratio asymptotics for orthogonal polynomials by extending and refining earlier results of Khrushchev. To demonstrate the analogy with the Jacobi case, we recover corresponding previous results of Simon using the same approach.
Rediscovery of the sun bear (Helarctos malayanus) in Yingjiang County,Yunnan Province,China.
Li, Fei; Zheng, Xi; Jiang, Xue-Long; Chan, Bosco Pui Lok
2017-07-18
The sun bear, Helarctos malayanus (Raffles, 1821), is a forest-dependent bear species distributed in tropical Southeast Asia. The species was previously reported from scattered localities in southwestern China, which is at the northeastern edge of its global range. Due to the scarcity of reliable recent records, some authorities cast doubt on the continued existence of sun bear in China. Here we present the rediscovery of this species in Yingjiang County, western Yunnan Province, China, near the international border with Myanmar's Kachin State.
Establishing and maintaining a satellite campus connected by synchronous video conferencing.
Fox, Brent I; McDonough, Sharon L; McConatha, Barry J; Marlowe, Karen F
2011-06-10
Pharmacy education has experienced substantial growth in the number of new schools and existing schools establishing satellite campuses. Several models have previously been used to connect primary and satellite campuses. We describe the Auburn University Harrison School of Pharmacy's (AUHSOP's) experiences using synchronous video conferencing between the Auburn University campus in Auburn and a satellite campus in Mobile, Alabama. We focus on the technology considerations related to planning, construction, implementation, and continued use of the various resources that support our program. Students' perceptions of their experiences related to technology also are described.
Results and conclusions: perception sensor study for high speed autonomous operations
NASA Astrophysics Data System (ADS)
Schneider, Anne; LaCelle, Zachary; Lacaze, Alberto; Murphy, Karl; Close, Ryan
2016-05-01
Previous research has presented work on sensor requirements, specifications, and testing, to evaluate the feasibility of increasing autonomous vehicle system speeds. Discussions included the theoretical background for determining sensor requirements, and the basic test setup and evaluation criteria for comparing existing and prototype sensor designs. This paper will present and discuss the continuation of this work. In particular, this paper will focus on analyzing the problem via a real-world comparison of various sensor technology testing results, as opposed to previous work that utilized more of a theoretical approach. LADAR/LIDAR, radar, visual, and infrared sensors are considered in this research. Results are evaluated against the theoretical, desired perception specifications. Conclusions for utilizing a suite of perception sensors, to achieve the goal of doubling ground vehicle speeds, is also discussed.
Code of Federal Regulations, 2010 CFR
2010-07-01
... Continuous Lamination Lines and Continuous Casting Lines Complying With a Lbs/Ton Organic HAP Emissions Limit... Requirements for New and Existing Continuous Lamination Lines and Continuous Casting Lines Complying With a Lbs... with a lbs/ton organic HAP emissions limit for continuous lamination lines and continuous casting lines...
NASA Technical Reports Server (NTRS)
Taylor, Gary O.
2001-01-01
John C. Stennis Space Center continues to support the Propulsion community in an effort to validate High-Test Peroxide as an alternative to existing/future oxidizers. This continued volume of peroxide test/handling activity at Stennis Space Center (SSC) provides numerous opportunities for the SSC team to build upon previously documented 'lessons learned'. SSC shall continue to strive to document their experience and findings as H2O2 issues surface. This paper is intended to capture all significant peroxide issues that we have learned over the last three years. This data (lessons learned) has been formulated from practical handling, usage, storage, operations, and initial development/design of our systems/facility viewpoint. The paper is intended to be an information type tool and limited in technical rational; therefore, presenting the peroxide community with some issues to think about as the continued interest in peroxide evolves and more facilities/hardware are built. These lessons learned are intended to assist industry in mitigating problems and identifying potential pitfalls when dealing with the requirements for handling high-test peroxide.
Field Trial Results of a 14-channel GPR Integrated with a U.S. Program for 3-D Utility Mapping
NASA Astrophysics Data System (ADS)
Anspach, James H.
2013-04-01
Existing underground utilities continue to be a leading cause of highway construction delay claims in the United States. Although 80-90% of existing utilities can typically be discovered and mapped using a wide range of geophysical tools, there is a recognizable need to improve the process. Existing shortcomings to the utility mapping process include a lack of viable depth attributes, long field occupation times, low experience level of the field technicians, and separate survey / geophysics functions. The U.S. National Academies and its Transportation Research Board recently concluded a project on alleviating the existing utility mapping shortcomings through the development of enhanced GPR. An existing commercial 400MHz 14-channel towed array was enhanced with positioning and interpretation hardware and software over a 3-year US 2M program. Field trials for effectiveness were conducted in a city suburb commercialized environment where the relative permittivity values averaged 9.4. The effectiveness of enhanced GPR was compared to traditional utility mapping techniques (Single Channel GPR, FDEM, Acoustic, Sondes, Gradiometric Magnetometers) during the project. The project area utilities included natural gas, water, electric, telephone, cable, storm, sanitary, traffic control, and several unknown function lines. Depths for these utilities were mostly unknown. 81% of known (from records and field appurtenance visual observation) utilities were detected via traditional geophysical means. These traditional geophysical means also detected 14% additional and previously "unknown" utilities. The enhanced GPR detected approximately 40% of the known and unknown utilities, and found an additional 6% of utilities that were previously undetected. These additional utilities were subsequently determined to be small diameter abandoned water and gas systems in very poor and broken condition. Although it did well with metallic water and gas lines, communication and electric utilities were mostly undetectable. Through a ground-truthing program of test holes to expose utilities, the depth values derived from the enhanced GPR were fairly consistent and within 15 cm of actual depth. The incomplete underground picture determined by the enhanced GPR reinforces previous studies that show that the mapping of existing underground utilities is a multi-tool effort that takes highly trained and skilled field technicians and data interpreters. The addition of a new GPR tool is valuable in determining continuous depth profiles of imaged utilities. A second and significant benefit is the interpretation of other geotechnical data that benefit project designers. This might include showing geometry, location, intensity, and depths of either areas of anomalies, or of known structures, such as paving thickness, substrate thickness, voids, water table, soil lenses, boulders, bedrock, and so forth. The Florida Department of Transportation has decided to take advantage of this new technology and has entered into an experimental contract with Cardno TBE to incorporate several enhanced GPR arrays with traditional utility detection tools. The goal of this contract will be to provide a 3-D model of existing underground utilities for use in automated construction. The GPR 3-D data model will be melded with conventional subsurface utility engineering and mapping practices and will be required to follow the ASCE 38 standard for utility data reliability.
Does artificial nutrition improve outcome of critical illness? An alternative viewpoint!
Heyland, Daren K; Wischmeyer, Paul E
2013-08-27
Recent studies challenge the beneficial role of artificial nutrition provided to critically ill patients and point out the limitations of existing studies in this area. We take a differing view of the existing data and refute many of the arguments put forward by previous authors. We review the mechanistic, observational, and experimental data supporting a role for early enteral nutrition in the critically ill patient. We conclude without question that more, high-quality research is needed to better define the role of artificial nutrition in the critical care setting, but until then early and adequate delivery of enteral nutrition is a legitimate, evidence-based treatment recommendation and we see no evidence-based role for restricting enteral nutrition in critically ill patients. The role of early supplemental parenteral nutrition continues to be defined as new data emerge.
7 CFR 1944.421 - Refunding of an existing grantee.
Code of Federal Regulations, 2010 CFR
2010-01-01
... AGRICULTURE (CONTINUED) PROGRAM REGULATIONS (CONTINUED) HOUSING Self-Help Technical Assistance Grants § 1944.421 Refunding of an existing grantee. Grantees wishing to continue with self-help efforts after the... 1944.421 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE...
7 CFR 1944.421 - Refunding of an existing grantee.
Code of Federal Regulations, 2011 CFR
2011-01-01
... AGRICULTURE (CONTINUED) PROGRAM REGULATIONS (CONTINUED) HOUSING Self-Help Technical Assistance Grants § 1944.421 Refunding of an existing grantee. Grantees wishing to continue with self-help efforts after the...
Predictive Modeling of Cardiac Ischemia
NASA Technical Reports Server (NTRS)
Anderson, Gary T.
1996-01-01
The goal of the Contextual Alarms Management System (CALMS) project is to develop sophisticated models to predict the onset of clinical cardiac ischemia before it occurs. The system will continuously monitor cardiac patients and set off an alarm when they appear about to suffer an ischemic episode. The models take as inputs information from patient history and combine it with continuously updated information extracted from blood pressure, oxygen saturation and ECG lines. Expert system, statistical, neural network and rough set methodologies are then used to forecast the onset of clinical ischemia before it transpires, thus allowing early intervention aimed at preventing morbid complications from occurring. The models will differ from previous attempts by including combinations of continuous and discrete inputs. A commercial medical instrumentation and software company has invested funds in the project with a goal of commercialization of the technology. The end product will be a system that analyzes physiologic parameters and produces an alarm when myocardial ischemia is present. If proven feasible, a CALMS-based system will be added to existing heart monitoring hardware.
Crawford, Forrest W.; Suchard, Marc A.
2011-01-01
A birth-death process is a continuous-time Markov chain that counts the number of particles in a system over time. In the general process with n current particles, a new particle is born with instantaneous rate λn and a particle dies with instantaneous rate μn. Currently no robust and efficient method exists to evaluate the finite-time transition probabilities in a general birth-death process with arbitrary birth and death rates. In this paper, we first revisit the theory of continued fractions to obtain expressions for the Laplace transforms of these transition probabilities and make explicit an important derivation connecting transition probabilities and continued fractions. We then develop an efficient algorithm for computing these probabilities that analyzes the error associated with approximations in the method. We demonstrate that this error-controlled method agrees with known solutions and outperforms previous approaches to computing these probabilities. Finally, we apply our novel method to several important problems in ecology, evolution, and genetics. PMID:21984359
Kulak, Alex N; Iddon, Peter; Li, Yuting; Armes, Steven P; Cölfen, Helmut; Paris, Oskar; Wilson, Rory M; Meldrum, Fiona C
2007-03-28
Two double-hydrophilic block copolymers, each comprising a nonionic block and an anionic block comprising pendent aromatic sulfonate groups, were used as additives to modify the crystallization of CaCO3. Marked morphological changes in the CaCO3 particles were observed depending on the reaction conditions used. A poly(ethylene oxide)-b-poly(sodium 4-styrenesulfonate) diblock copolymer was particularly versatile in effecting a morphological change in calcite particles, and a continuous structural transition in the product particles from polycrystalline to mesocrystal to single crystal was observed with variation in the calcium concentration. The existence of this structural sequence provides unique insight into the mechanism of polymer-mediated crystallization. We propose that it reflects continuity in the crystallization mechanism itself, spanning the limits from nonoriented aggregation of nanoparticles to classical ion-by-ion growth. The various pathways to polycrystalline, mesocrystal, and single-crystal particles, which had previously been considered to be distinct, therefore all form part of a unifying crystallization framework based on the aggregation of precursor subunits.
A lifelong learning hyper-heuristic method for bin packing.
Sim, Kevin; Hart, Emma; Paechter, Ben
2015-01-01
We describe a novel hyper-heuristic system that continuously learns over time to solve a combinatorial optimisation problem. The system continuously generates new heuristics and samples problems from its environment; and representative problems and heuristics are incorporated into a self-sustaining network of interacting entities inspired by methods in artificial immune systems. The network is plastic in both its structure and content, leading to the following properties: it exploits existing knowledge captured in the network to rapidly produce solutions; it can adapt to new problems with widely differing characteristics; and it is capable of generalising over the problem space. The system is tested on a large corpus of 3,968 new instances of 1D bin-packing problems as well as on 1,370 existing problems from the literature; it shows excellent performance in terms of the quality of solutions obtained across the datasets and in adapting to dynamically changing sets of problem instances compared to previous approaches. As the network self-adapts to sustain a minimal repertoire of both problems and heuristics that form a representative map of the problem space, the system is further shown to be computationally efficient and therefore scalable.
An improved cellular automaton method to model multispecies biofilms.
Tang, Youneng; Valocchi, Albert J
2013-10-01
Biomass-spreading rules used in previous cellular automaton methods to simulate multispecies biofilm introduced extensive mixing between different biomass species or resulted in spatially discontinuous biomass concentration and distribution; this caused results based on the cellular automaton methods to deviate from experimental results and those from the more computationally intensive continuous method. To overcome the problems, we propose new biomass-spreading rules in this work: Excess biomass spreads by pushing a line of grid cells that are on the shortest path from the source grid cell to the destination grid cell, and the fractions of different biomass species in the grid cells on the path change due to the spreading. To evaluate the new rules, three two-dimensional simulation examples are used to compare the biomass distribution computed using the continuous method and three cellular automaton methods, one based on the new rules and the other two based on rules presented in two previous studies. The relationship between the biomass species is syntrophic in one example and competitive in the other two examples. Simulation results generated using the cellular automaton method based on the new rules agree much better with the continuous method than do results using the other two cellular automaton methods. The new biomass-spreading rules are no more complex to implement than the existing rules. Copyright © 2013 Elsevier Ltd. All rights reserved.
Acoustic waveform of continuous bubbling in a non-Newtonian fluid.
Vidal, Valérie; Ichihara, Mie; Ripepe, Maurizio; Kurita, Kei
2009-12-01
We study experimentally the acoustic signal associated with a continuous bubble bursting at the free surface of a non-Newtonian fluid. Due to the fluid rheological properties, the bubble shape is elongated, and, when bursting at the free surface, acts as a resonator. For a given fluid concentration, at constant flow rate, repetitive bubble bursting occurs at the surface. We report a modulation pattern of the acoustic waveform through time. Moreover, we point out the existence of a precursor acoustic signal, recorded on the microphone array, previous to each bursting. The time delay between this precursor and the bursting signal is well correlated with the bursting signal frequency content. Their joint modulation through time is driven by the fluid rheology, which strongly depends on the presence of small satellite bubbles trapped in the fluid due to the yield stress.
Arik, Sabri
2005-05-01
This paper presents a sufficient condition for the existence, uniqueness and global asymptotic stability of the equilibrium point for bidirectional associative memory (BAM) neural networks with distributed time delays. The results impose constraint conditions on the network parameters of neural system independently of the delay parameter, and they are applicable to all continuous nonmonotonic neuron activation functions. It is shown that in some special cases of the results, the stability criteria can be easily checked. Some examples are also given to compare the results with the previous results derived in the literature.
[On machines and instruments (II): the world in the eye of the work of E. T. A. Hoffmann].
Montiel, L
2008-01-01
Continuing with the subject of the previous work, this article considers the whole series of problems connected to the question of vision provoked by the mere existence of the body of the automaton. The eyes of the android and, above all, the reactions aroused by looking at these human-shaped machines are the object of Hoffman's reflections, from a viewpoint apparently firmly set within the Goethean concept of the
Stochastic Stabilityfor Contracting Lorenz Maps and Flows
NASA Astrophysics Data System (ADS)
Metzger, R. J.
In a previous work [M], we proved the existence of absolutely continuous invariant measures for contracting Lorenz-like maps, and constructed Sinai-Ruelle-Bowen measures f or the flows that generate them. Here, we prove stochastic stability for such one-dimensional maps and use this result to prove that the corresponding flows generating these maps are stochastically stable under small diffusion-type perturbations, even though, as shown by Rovella [Ro], they are persistent only in a measure theoretical sense in a parameter space. For the one-dimensional maps we also prove strong stochastic stability in the sense of Baladi and Viana[BV].
Establishing and Maintaining a Satellite Campus Connected by Synchronous Video Conferencing
Fox, Brent I.; McDonough, Sharon L.; McConatha, Barry J.; Marlowe, Karen F.
2011-01-01
Pharmacy education has experienced substantial growth in the number of new schools and existing schools establishing satellite campuses. Several models have previously been used to connect primary and satellite campuses. We describe the Auburn University Harrison School of Pharmacy's (AUHSOP's) experiences using synchronous video conferencing between the Auburn University campus in Auburn and a satellite campus in Mobile, Alabama. We focus on the technology considerations related to planning, construction, implementation, and continued use of the various resources that support our program. Students’ perceptions of their experiences related to technology also are described. PMID:21829265
History Matters: Incremental Ontology Reasoning Using Modules
NASA Astrophysics Data System (ADS)
Cuenca Grau, Bernardo; Halaschek-Wiener, Christian; Kazakov, Yevgeny
The development of ontologies involves continuous but relatively small modifications. Existing ontology reasoners, however, do not take advantage of the similarities between different versions of an ontology. In this paper, we propose a technique for incremental reasoning—that is, reasoning that reuses information obtained from previous versions of an ontology—based on the notion of a module. Our technique does not depend on a particular reasoning calculus and thus can be used in combination with any reasoner. We have applied our results to incremental classification of OWL DL ontologies and found significant improvement over regular classification time on a set of real-world ontologies.
Cacchione, Trix; Call, Josep
2010-08-01
Recent research suggests that witnessing events of fission (e.g., the splitting of a solid object) impairs human infants', human adults', and non-human primates' object representations. The present studies investigated the reactions of gorillas and orangutans to cohesion violation across different types of fission events implementing a behavioral paradigm previously used with human infants. Results suggest that fission events vary in their impact on representational abilities but do not destroy apes' representations of continuously existing objects. Copyright (c) 2010 Elsevier B.V. All rights reserved.
Bradley, Dwight C.; Wilson, Frederic H.
2000-01-01
We present a new reconnaissance geologic map of the southeastern part of the Kenai quadrangle that improves on previously published maps. Melange of the McHugh Complex is now known to form a continuous strike belt that can be traced from the Seldovia to the Valdez quadrangle; a problematic 75-km-long gap in the McHugh Complex in the Kenai and Seldovia quadrangles does not exist. An Eocene near-trench pluton underlies a range of nunataks in Harding Icefield.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Data Requirements for New and Existing Continuous Lamination Lines and Continuous Casting Lines Complying With a Percent Reduction Limit on a Per Line Basis 10 Table 10 to Subpart WWWW of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUE...
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 12 2011-07-01 2009-07-01 true Data Requirements for New and Existing Continuous Lamination Lines and Continuous Casting Lines Complying With a Percent Reduction Limit on a Per Line Basis 10 Table 10 to Subpart WWWW of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUE...
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 13 2013-07-01 2012-07-01 true Data Requirements for New and Existing Continuous Lamination Lines and Continuous Casting Lines Complying With a Percent Reduction Limit on a Per Line Basis 10 Table 10 to Subpart WWWW of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUE...
47 CFR 54.604 - Existing contracts.
Code of Federal Regulations, 2010 CFR
2010-10-01
... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES (CONTINUED) UNIVERSAL SERVICE Universal Service Support for Health Care Providers § 54.604 Existing contracts. (a) Existing... health care provider as defined under § 54.601 and a telecommunications carrier shall be exempt from the...
The proactive brain: memory for predictions
Bar, Moshe
2009-01-01
It is proposed that the human brain is proactive in that it continuously generates predictions that anticipate the relevant future. In this proposal, analogies are derived from elementary information that is extracted rapidly from the input, to link that input with the representations that exist in memory. Finding an analogical link results in the generation of focused predictions via associative activation of representations that are relevant to this analogy, in the given context. Predictions in complex circumstances, such as social interactions, combine multiple analogies. Such predictions need not be created afresh in new situations, but rather rely on existing scripts in memory, which are the result of real as well as of previously imagined experiences. This cognitive neuroscience framework provides a new hypothesis with which to consider the purpose of memory, and can help explain a variety of phenomena, ranging from recognition to first impressions, and from the brain's ‘default mode’ to a host of mental disorders. PMID:19528004
Prethermal Phases of Matter Protected by Time-Translation Symmetry
NASA Astrophysics Data System (ADS)
Else, Dominic V.; Bauer, Bela; Nayak, Chetan
2017-01-01
In a periodically driven (Floquet) system, there is the possibility for new phases of matter, not present in stationary systems, protected by discrete time-translation symmetry. This includes topological phases protected in part by time-translation symmetry, as well as phases distinguished by the spontaneous breaking of this symmetry, dubbed "Floquet time crystals." We show that such phases of matter can exist in the prethermal regime of periodically driven systems, which exists generically for sufficiently large drive frequency, thereby eliminating the need for integrability or strong quenched disorder, which limited previous constructions. We prove a theorem that states that such a prethermal regime persists until times that are nearly exponentially long in the ratio of certain couplings to the drive frequency. By similar techniques, we can also construct stationary systems that spontaneously break continuous time-translation symmetry. Furthermore, we argue that for driven systems coupled to a cold bath, the prethermal regime could potentially persist to infinite time.
Nowicki, Dimitri; Siegelmann, Hava
2010-01-01
This paper introduces a new model of associative memory, capable of both binary and continuous-valued inputs. Based on kernel theory, the memory model is on one hand a generalization of Radial Basis Function networks and, on the other, is in feature space, analogous to a Hopfield network. Attractors can be added, deleted, and updated on-line simply, without harming existing memories, and the number of attractors is independent of input dimension. Input vectors do not have to adhere to a fixed or bounded dimensionality; they can increase and decrease it without relearning previous memories. A memory consolidation process enables the network to generalize concepts and form clusters of input data, which outperforms many unsupervised clustering techniques; this process is demonstrated on handwritten digits from MNIST. Another process, reminiscent of memory reconsolidation is introduced, in which existing memories are refreshed and tuned with new inputs; this process is demonstrated on series of morphed faces. PMID:20552013
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 13 2014-07-01 2014-07-01 false Data Requirements for New and Existing Continuous Lamination Lines and Continuous Casting Lines Complying With a Percent Reduction Limit on a Per Line Basis 10 Table 10 to Subpart WWWW of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS ...
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 13 2012-07-01 2012-07-01 false Data Requirements for New and Existing Continuous Lamination Lines and Continuous Casting Lines Complying With a Percent Reduction Limit on a Per Line Basis 10 Table 10 to Subpart WWWW of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS ...
Slab stagnation and detachment under northeast China
NASA Astrophysics Data System (ADS)
Honda, Satoru
2016-03-01
Results of tomography models around the Japanese Islands show the existence of a gap between the horizontally lying (stagnant) slab extending under northeastern China and the fast seismic velocity anomaly in the lower mantle. A simple conversion from the fast velocity anomaly to the low-temperature anomaly shows a similar feature. This feature appears to be inconsistent with the results of numerical simulations on the interaction between the slab and phase transitions with temperature-dependent viscosity. Such numerical models predict a continuous slab throughout the mantle. I extend previous analyses of the tomography model and model calculations to infer the origins of the gap beneath northeastern China. Results of numerical simulations that take the geologic history of the subduction zone into account suggest two possible origins for the gap: (1) the opening of the Japan Sea led to a breaking off of the otherwise continuous subducting slab, or (2) the western edge of the stagnant slab is the previous subducted ridge, which was the plate boundary between the extinct Izanagi and the Pacific plates. Origin (2) suggesting the present horizontally lying slab has accumulated since the ridge subduction, is preferable for explaining the present length of the horizontally lying slab in the upper mantle. Numerical models of origin (1) predict a stagnant slab in the upper mantle that is too short, and a narrow or non-existent gap. Preferred models require rather stronger flow resistance of the 660-km phase change than expected from current estimates of the phase transition property. Future detailed estimates of the amount of the subducted Izanagi plate and the present stagnant slab would be useful to constrain models. A systematic along-arc variation of the slab morphology from the northeast Japan to Kurile arcs is also recognized, and its understanding may constrain the 3D mantle flow there.
NASA Technical Reports Server (NTRS)
Tuey, Richard C.; Lane, Robert; Hart, Susan V.
1995-01-01
The NASA Scientific and Technical Information Office was assigned the responsibility to continue with the expansion of the NASAwide networked electronic duplicating effort by including the Goddard Space Flight Center (GSFC) as an additional node to the existing configuration of networked electronic duplicating systems within NASA. The subject of this report is the evaluation of a networked electronic duplicating system which meets the duplicating requirements and expands electronic publishing capabilities without increasing current operating costs. This report continues the evaluation reported in 'NASA Electronic Publishing System - Electronic Printing and Duplicating Evaluation Report' (NASA TM-106242) and 'NASA Electronic Publishing System - Stage 1 Evaluation Report' (NASA TM-106510). This report differs from the previous reports through the inclusion of an external networked desktop editing, archival, and publishing functionality which did not exist with the previous networked electronic duplicating system. Additionally, a two-phase approach to the evaluation was undertaken; the first was a paper study justifying a 90-day, on-site evaluation, and the second phase was to validate, during the 90-day evaluation, the cost benefits and productivity increases that could be achieved in an operational mode. A benchmark of the functionality of the networked electronic publishing system and external networked desktop editing, archival, and publishing system was performed under a simulated daily production environment. This report can be used to guide others in determining the most cost effective duplicating/publishing alternative through the use of cost/benefit analysis and return on investment techniques. A treatise on the use of these techniques can be found by referring to 'NASA Electronic Publishing System -Cost/Benefit Methodology' (NASA TM-106662).
Data Access and Web Services at the EarthScope Plate Boundary Observatory
NASA Astrophysics Data System (ADS)
Matykiewicz, J.; Anderson, G.; Henderson, D.; Hodgkinson, K.; Hoyt, B.; Lee, E.; Persson, E.; Torrez, D.; Smith, J.; Wright, J.; Jackson, M.
2007-12-01
The EarthScope Plate Boundary Observatory (PBO) at UNAVCO, Inc., part of the NSF-funded EarthScope project, is designed to study the three-dimensional strain field resulting from deformation across the active boundary zone between the Pacific and North American plates in the western United States. To meet these goals, PBO will install 880 continuous GPS stations, 103 borehole strainmeter stations, and five laser strainmeters, as well as manage data for 209 previously existing continuous GPS stations and one previously existing laser strainmeter. UNAVCO provides access to data products from these stations, as well as general information about the PBO project, via the PBO web site (http://pboweb.unavco.org). GPS and strainmeter data products can be found using a variety of access methods, incuding map searches, text searches, and station specific data retrieval. In addition, the PBO construction status is available via multiple mapping interfaces, including custom web based map widgets and Google Earth. Additional construction details can be accessed from PBO operational pages and station specific home pages. The current state of health for the PBO network is available with the statistical snap-shot, full map interfaces, tabular web based reports, and automatic data mining and alerts. UNAVCO is currently working to enhance the community access to this information by developing a web service framework for the discovery of data products, interfacing with operational engineers, and exposing data services to third party participants. In addition, UNAVCO, through the PBO project, provides advanced data management and monitoring systems for use by the community in operating geodetic networks in the United States and beyond. We will demonstrate these systems during the AGU meeting, and we welcome inquiries from the community at any time.
NASA Astrophysics Data System (ADS)
Ripepe, M.; Marchetti, E.; Bonadonna, C.; Harris, A. J. L.; Pioli, L.; Ulivieri, G.
2010-08-01
Infrasonic data collected at Villarrica volcano (Chile) in March 2009 show a sustained, continuous, infrasonic oscillation (tremor) with a monochromatic low frequency content at ˜0.75 Hz. This tremor is extremely stable in time both at the summit and at a distal (˜4 km) small aperture array. Infrasonic tremor is characterized by discrete high amplitude bursts with a cyclic recurrence time of ˜40 s and is well correlated (0.93) with seismic tremor. These new data are compared with previous datasets collected in 2002 and 2004 during different levels of activity. All data show the same persistent infrasonic tremor and have the same strong correlation with seismic tremor. The stability and correlation of infrasonic and seismic tremor indicate the existence of a sustained and continuous process, which we suggest is related to the gravity-driven bubble column dynamics responsible for conduit convection.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Eisenbach, Markus; Li, Ying Wai
We report a new multicanonical Monte Carlo (MC) algorithm to obtain the density of states (DOS) for physical systems with continuous state variables in statistical mechanics. Our algorithm is able to obtain an analytical form for the DOS expressed in a chosen basis set, instead of a numerical array of finite resolution as in previous variants of this class of MC methods such as the multicanonical (MUCA) sampling and Wang-Landau (WL) sampling. This is enabled by storing the visited states directly in a data set and avoiding the explicit collection of a histogram. This practice also has the advantage ofmore » avoiding undesirable artificial errors caused by the discretization and binning of continuous state variables. Our results show that this scheme is capable of obtaining converged results with a much reduced number of Monte Carlo steps, leading to a significant speedup over existing algorithms.« less
Absolute continuity for operator valued completely positive maps on C∗-algebras
NASA Astrophysics Data System (ADS)
Gheondea, Aurelian; Kavruk, Ali Şamil
2009-02-01
Motivated by applicability to quantum operations, quantum information, and quantum probability, we investigate the notion of absolute continuity for operator valued completely positive maps on C∗-algebras, previously introduced by Parthasarathy [in Athens Conference on Applied Probability and Time Series Analysis I (Springer-Verlag, Berlin, 1996), pp. 34-54]. We obtain an intrinsic definition of absolute continuity, we show that the Lebesgue decomposition defined by Parthasarathy is the maximal one among all other Lebesgue-type decompositions and that this maximal Lebesgue decomposition does not depend on the jointly dominating completely positive map, we obtain more flexible formulas for calculating the maximal Lebesgue decomposition, and we point out the nonuniqueness of the Lebesgue decomposition as well as a sufficient condition for uniqueness. In addition, we consider Radon-Nikodym derivatives for absolutely continuous completely positive maps that, in general, are unbounded positive self-adjoint operators affiliated to a certain von Neumann algebra, and we obtain a spectral approximation by bounded Radon-Nikodym derivatives. An application to the existence of the infimum of two completely positive maps is indicated, and formulas in terms of Choi's matrices for the Lebesgue decomposition of completely positive maps in matrix algebras are obtained.
Clawson, Art; Menachemi, Nir; Kim, Unho; Brooks, Robert G
2007-01-01
The US continues to be a target for terrorist activities that threaten the lives of the populace. Training on preparedness and response for emergency medical technicians (EMTs) and paramedics is critical to the success of an early response to any such attack. Previous surveys have suggested that terrorism-specific training has been modest at best since September 11. In order to gain further insight into emergency personnel's level of training and competence, we sent surveys to 4,000 EMTs and paramedics in the state of Florida in late 2005 and early 2006. Results show a much higher level of training than previously reported from other states and suggest a direct correlation between the amount and type of training and self-reported competence. Our results suggest that most emergency personnel are receiving terrorism-specific training, but gaps in competencies exist and require the attention of educators and policymakers.
32 CFR 651.46 - Existing EISs.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 32 National Defense 4 2010-07-01 2010-07-01 true Existing EISs. 651.46 Section 651.46 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) ENVIRONMENTAL QUALITY ENVIRONMENTAL ANALYSIS OF ARMY ACTIONS (AR 200-2) Environmental Impact Statement § 651.46 Existing EISs. A newly...
40 CFR 63.11527 - What are the monitoring requirements for new and existing sources?
Code of Federal Regulations, 2014 CFR
2014-07-01
... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for... an existing affected source, you may install, operate, and maintain a bag leak detection system for...
40 CFR 63.11527 - What are the monitoring requirements for new and existing sources?
Code of Federal Regulations, 2013 CFR
2013-07-01
... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for... an existing affected source, you may install, operate, and maintain a bag leak detection system for...
40 CFR 63.11527 - What are the monitoring requirements for new and existing sources?
Code of Federal Regulations, 2012 CFR
2012-07-01
... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for... an existing affected source, you may install, operate, and maintain a bag leak detection system for...
Topology-induced bifurcations for the nonlinear Schrödinger equation on the tadpole graph.
Cacciapuoti, Claudio; Finco, Domenico; Noja, Diego
2015-01-01
In this paper we give the complete classification of solitons for a cubic nonlinear Schrödinger equation on the simplest network with a nontrivial topology: the tadpole graph, i.e., a ring with a half line attached to it and free boundary conditions at the junction. This is a step toward the modelization of condensate propagation and confinement in quasi-one-dimensional traps. The model, although simple, exhibits a surprisingly rich behavior and in particular we show that it admits: (i) a denumerable family of continuous branches of embedded solitons vanishing on the half line and bifurcating from linear eigenstates and threshold resonances of the system; (ii) a continuous branch of edge solitons bifurcating from the previous families at the threshold of the continuous spectrum with a pitchfork bifurcation; and (iii) a finite family of continuous branches of solitons without linear analog. All the solutions are explicitly constructed in terms of elliptic Jacobian functions. Moreover we show that families of nonlinear bound states of the above kind continue to exist in the presence of a uniform magnetic field orthogonal to the plane of the ring when a well definite flux quantization condition holds true. In this sense the magnetic field acts as a control parameter. Finally we highlight the role of resonances in the linearization as a signature of the occurrence of bifurcations of solitons from the continuous spectrum.
Modern Methods of Rail Welding
NASA Astrophysics Data System (ADS)
Kozyrev, Nikolay A.; Kozyreva, Olga A.; Usoltsev, Aleksander A.; Kryukov, Roman E.; Shevchenko, Roman A.
2017-10-01
Existing methods of rail welding, which are enable to get continuous welded rail track, are observed in this article. Analysis of existing welding methods allows considering an issue of continuous rail track in detail. Metallurgical and welding technologies of rail welding and also process technologies reducing aftereffects of temperature exposure are important factors determining the quality and reliability of the continuous rail track. Analysis of the existing methods of rail welding enable to find the research line for solving this problem.
Irish, Joel D
2005-11-01
The present study revisits a subject that has been a source of long-standing bioarchaeological contention, namely, estimation of Nubian population origins and affinities. Using the Arizona State University dental anthropology system, frequencies of 36 crown, root, and intraoral osseous discrete traits in 12 late Pleistocene through early historic Nubian samples were recorded and analyzed. Specifically, intersample phenetic affinities, and an indication of which traits are most important in driving this variation, were determined through the application of correspondence analysis and the mean measure of divergence distance statistic. The results support previous work by the author and others indicating that population discontinuity, in the form of replacement or significant gene flow into an existing gene pool, occurred sometime after the Pleistocene. This analysis now suggests that the break occurred before the Final Neolithic. Samples from the latter through Christian periods exhibit relative homogeneity, which implies overall post-Pleistocene diachronic and regional population continuity. Yet there are several perceptible trends among these latter samples that: 1) are consistent with documented Nubian population history, 2) enable the testing of several existing peopling hypotheses, and 3) allow the formulation of new hypotheses, including a suggestion of two post-Pleistocene subgroups predicated on an age-based sample dichotomy. Copyright 2005 Wiley-Liss, Inc
Micro-Doppler analysis of multiple frequency continuous wave radar signatures
NASA Astrophysics Data System (ADS)
Anderson, Michael G.; Rogers, Robert L.
2007-04-01
Micro-Doppler refers to Doppler scattering returns produced by non rigid-body motion. Micro-Doppler gives rise to many detailed radar image features in addition to those associated with bulk target motion. Targets of different classes (for example, humans, animals, and vehicles) produce micro-Doppler images that are often distinguishable even by nonexpert observers. Micro-Doppler features have great potential for use in automatic target classification algorithms. Although the potential benefit of using micro-Doppler in classification algorithms is high, relatively little experimental (non-synthetic) micro-Doppler data exists. Much of the existing experimental data comes from highly cooperative targets (human or vehicle targets directly approaching the radar). This research involved field data collection and analysis of micro-Doppler radar signatures from non-cooperative targets. The data was collected using a low cost Xband multiple frequency continuous wave (MFCW) radar with three transmit frequencies. The collected MFCW radar signatures contain data from humans, vehicles, and animals. The presented data includes micro-Doppler signatures previously unavailable in the literature such as crawling humans and various animal species. The animal micro-Doppler signatures include deer, dog, and goat datasets. This research focuses on the analysis of micro-Doppler from noncooperative targets approaching the radar at various angles, maneuvers, and postures.
Democratization as a United States Strategy for Middle East Security
2005-03-18
the Middle East presents a wide variety of governments across the region. Republics exists in Algeria, Egypt, Lebanon , Syria, Tunisia, and Yemen...PF 4 5 PF 4 5 PF 4 5 PF 4 5 PF Lebanon 6 5 NF 6 5 NF 6 5 NF 6 5 NF 6 5 NF Libya 7 7 NF 7 7 NF 7 7 NF 7 7 NF 7 7 NF Morocco 5 4 PF 5 5 PF 5 5 PF 5 5...more open discussion of previously taboo topics.17 Syria’s firm control continues to be the greatest impediment to freedom in Lebanon . The Lebanese
Beretta, E; Capasso, V; Rinaldi, F
1988-01-01
The paper contains an extension of the general ODE system proposed in previous papers by the same authors, to include distributed time delays in the interaction terms. The new system describes a large class of Lotka-Volterra like population models and epidemic models with continuous time delays. Sufficient conditions for the boundedness of solutions and for the global asymptotic stability of nontrivial equilibrium solutions are given. A detailed analysis of the epidemic system is given with respect to the conditions for global stability. For a relevant subclass of these systems an existence criterion for steady states is also given.
Towards new uses of botulinum toxin as a novel therapeutic tool.
Pickett, Andy; Perrow, Karen
2011-01-01
The uses of botulinum toxin in the fields of neurology, ophthalmology, urology, rehabilitation medicine and aesthetic applications have been revolutionary for the treatment of patients. This non-invasive therapeutic has continually been developed since first discovered in the 1970s as a new approach to what were previously surgical treatments. As these applications develop, so also the molecules are developing into tools with new therapeutic properties in specific clinical areas. This review examines how the botulinum toxin molecule is being adapted to new therapeutic uses and also how new areas of use for the existing molecules are being identified. Prospects for future developments are also considered.
Zeng, Cheng; Liang, Shan; Xiang, Shuwen
2017-05-01
Continuous-time systems are usually modelled by the form of ordinary differential equations arising from physical laws. However, the use of these models in practice and utilizing, analyzing or transmitting these data from such systems must first invariably be discretized. More importantly, for digital control of a continuous-time nonlinear system, a good sampled-data model is required. This paper investigates the new consistency condition which is weaker than the previous similar results presented. Moreover, given the stability of the high-order approximate model with stable zero dynamics, the novel condition presented stabilizes the exact sampled-data model of the nonlinear system for sufficiently small sampling periods. An insightful interpretation of the obtained results can be made in terms of the stable sampling zero dynamics, and the new consistency condition is surprisingly associated with the relative degree of the nonlinear continuous-time system. Our controller design, based on the higher-order approximate discretized model, extends the existing methods which mainly deal with the Euler approximation. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.
An enzyme-coupled continuous fluorescence assay for farnesyl diphosphate synthases
Dozier, Jonathan K; Distefano, Mark D
2012-01-01
Farnesyl diphosphate synthase (FDPS) catalyzes the conversion of isopentenyl diphosphate and dimethylallyl diphosphate to farnesyl diphosphate, a crucial metabolic intermediate in the synthesis of cholesterol, ubiquinone and prenylated proteins; consequently, much effort has gone into developing inhibitors that target FDPS. Currently most FDPS assays use either radiolabeled substrates and are discontinuous, or monitor pyrophosphate release and not farnesyl diphosphate (FPP) creation. Here we report the development of a continuous coupled enzyme assay for FDPS activity that involves the subsequent incorporation of the FPP product of that reaction into a peptide via the action of protein farnesyltransferase (PFTase). By using a dansylated peptide whose fluorescence quantum yield increases upon farnesylation, the rate of FDPS-catalyzed FPP production can be measured. We show that this assay is more sensitive than existing coupled assays, that it can be used to conveniently monitor FDPS activity in a 96-well plate format and that it can reproduce IC50 values for several previously reported FDPS inhibitors. This new method offers a simple, safe and continuous method to assay FDPS activity that should greatly facilitate the screening of inhibitors of this important target. PMID:22085443
Diversification and the rate of molecular evolution: no evidence of a link in mammals.
Goldie, Xavier; Lanfear, Robert; Bromham, Lindell
2011-10-04
Recent research has indicated a positive association between rates of molecular evolution and diversification in a number of taxa. However debate continues concerning the universality and cause of this relationship. Here, we present the first systematic investigation of this relationship within the mammals. We use phylogenetically independent sister-pair comparisons to test for a relationship between substitution rates and clade size at a number of taxonomic levels. Total, non-synonymous and synonymous substitution rates were estimated from mitochondrial and nuclear DNA sequences. We found no evidence for an association between clade size and substitution rates in mammals, for either the nuclear or the mitochondrial sequences. We found significant associations between body size and substitution rates, as previously reported. Our results present a contrast to previous research, which has reported significant positive associations between substitution rates and diversification for birds, angiosperms and reptiles. There are three possible reasons for the differences between the observed results in mammals versus other clades. First, there may be no link between substitution rates and diversification in mammals. Second, this link may exist, but may be much weaker in mammals than in other clades. Third, the link between substitution rates and diversification may exist in mammals, but may be confounded by other variables.
NASA Astrophysics Data System (ADS)
Bhattacharjee, N.; Horowitz, L. F.; Folch, A.
2016-10-01
Concerns over biosafety, cost, and carrying capacity of viral vectors have accelerated research into physical techniques for gene delivery such as electroporation and mechanoporation. Advances in microfabrication have made it possible to create high electric fields over microscales, resulting in more efficient DNA delivery and higher cell viability. Continuous-flow microfluidic methods are typically more suitable for cellular therapies where a large number of cells need to be transfected under sterile conditions. However, the existing continuous-flow designs used to generate multiple pulses either require expensive peripherals such as high-voltage (>400 V) sources or function generators, or result in reduced cell viability due to the proximity of the cells to the electrodes. In this paper, we report a continuous-flow microfluidic device whose channel geometry reduces instrumentation demands and minimizes cellular toxicity. Our design can generate multiple pulses of high DC electric field strength using significantly lower voltages (15-60 V) than previous designs. The cells flow along a serpentine channel that repeatedly flips the cells between a cathode and an anode at high throughput. The cells must flow through a constriction each time they pass from an anode to a cathode, exposing them to high electric field strength for short durations of time (the "pulse-width"). A conductive biocompatible poly-aniline hydrogel network formed in situ is used to apply the DC voltage without bringing the metal electrodes close to the cells, further sheltering cells from the already low voltage electrodes. The device was used to electroporate multiple cell lines using electric field strengths between 700 and 800 V/cm with transfection efficiencies superior than previous flow-through designs.
Bhattacharjee, N; Horowitz, L F; Folch, A
2016-10-17
Concerns over biosafety, cost, and carrying capacity of viral vectors have accelerated research into physical techniques for gene delivery such as electroporation and mechanoporation. Advances in microfabrication have made it possible to create high electric fields over microscales, resulting in more efficient DNA delivery and higher cell viability. Continuous-flow microfluidic methods are typically more suitable for cellular therapies where a large number of cells need to be transfected under sterile conditions. However, the existing continuous-flow designs used to generate multiple pulses either require expensive peripherals such as high-voltage (>400 V) sources or function generators, or result in reduced cell viability due to the proximity of the cells to the electrodes. In this paper, we report a continuous-flow microfluidic device whose channel geometry reduces instrumentation demands and minimizes cellular toxicity. Our design can generate multiple pulses of high DC electric field strength using significantly lower voltages (15-60 V) than previous designs. The cells flow along a serpentine channel that repeatedly flips the cells between a cathode and an anode at high throughput. The cells must flow through a constriction each time they pass from an anode to a cathode, exposing them to high electric field strength for short durations of time (the "pulse-width"). A conductive biocompatible poly-aniline hydrogel network formed in situ is used to apply the DC voltage without bringing the metal electrodes close to the cells, further sheltering cells from the already low voltage electrodes. The device was used to electroporate multiple cell lines using electric field strengths between 700 and 800 V/cm with transfection efficiencies superior than previous flow-through designs.
Benkhadra, Khalid; Alahdab, Fares; Tamhane, Shrikant U; McCoy, Rozalina G; Prokop, Larry J; Murad, Mohammad Hassan
2017-01-01
The relative efficacy of continuous subcutaneous insulin infusion and multiple daily injections in individuals with type 1 diabetes is unclear. We sought to synthesize the existing evidence about the effect of continuous subcutaneous insulin infusion on glycosylated hemoglobin, hypoglycemic events, and time spent in hypoglycemia compared to multiple daily injections. We searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials and Database of Systematic Reviews, and Scopus from January 2008 through November 2015 for randomized controlled trials that enrolled children or adults with type 1 diabetes. Trials identified in a previous systematic review and published prior to 2008 were also included. We included 25 randomized controlled trials at moderate risk of bias. Meta-analysis showed a significant reduction in glycosylated hemoglobin in patients treated with continuous subcutaneous insulin infusion compared to multiple daily injections (mean difference 0.37; 95 % confidence interval, 0.24-0.51). This effect was demonstrated in both children and adults. There was no significant difference in minor or severe hypoglycemic events. Continuous subcutaneous insulin infusion was associated with lower incidence of nocturnal hypoglycemia. There was no significant difference in the time spent in hypoglycemia. In children and adults with type 1 diabetes and compared to multiple daily injections, continuous subcutaneous insulin infusion is associated with a modest reduction in glycosylated hemoglobin. There was no difference in severe or minor hypoglycemia, but likely a lower incidence of nocturnal hypoglycemia with continuous subcutaneous insulin infusion.
Laboratory management of perinatal patients with apparently "new" anti-D.
Hannon, Judith L; Clarke, Gwen
2016-09-01
Despite the existence of long-standing, well-organized programs for Rh immune globulin (RhIG) prophylaxis, immune anti-D continues to be detected in the D– perinatal population. Between 2006 and 2008, 91 prenatal patients, found to have a previously unidentified anti-D, were followed up with a survey to their treating physician and with additional serologic testing where possible. The physician survey requested pregnancy and RhIG history information, including recent or distant potential alloimmunizing events, and the physicians were asked their opinion on the likely cause for the anti-D. Based on survey responses, updated RhIG information, and results of follow-up serology, anti-D was determined to be attributable to previously unreported RhIG in 44 of 91 (48.3%) cases and to active immunization (immune anti-D) in 36 of 91 cases (39.6%). A probable cause for alloimmunization was reported in 14 of 52 (26.9%) returned surveys. Anti-D alloimmunization continues to occur in our prenatal population despite a comprehensive approach to RhIG therapy. Observations from this prospective patient management strategy include the need for improved application of guidelines for RhIG administration and improved quality of information provided to laboratories assessing RhIG eligibility. A laboratory process for prospective follow-up when unexpected anti-D is detected in pregnancy is recommended.
5 CFR 894.102 - If I have a pre-existing dental or vision condition, may I join FEDVIP?
Code of Federal Regulations, 2013 CFR
2013-01-01
... 5 Administrative Personnel 2 2013-01-01 2013-01-01 false If I have a pre-existing dental or vision... MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL EMPLOYEES DENTAL AND VISION INSURANCE PROGRAM Administration and General Provisions § 894.102 If I have a pre-existing dental or vision...
5 CFR 894.102 - If I have a pre-existing dental or vision condition, may I join FEDVIP?
Code of Federal Regulations, 2014 CFR
2014-01-01
... 5 Administrative Personnel 2 2014-01-01 2014-01-01 false If I have a pre-existing dental or vision... MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL EMPLOYEES DENTAL AND VISION INSURANCE PROGRAM Administration and General Provisions § 894.102 If I have a pre-existing dental or vision...
5 CFR 894.102 - If I have a pre-existing dental or vision condition, may I join FEDVIP?
Code of Federal Regulations, 2012 CFR
2012-01-01
... 5 Administrative Personnel 2 2012-01-01 2012-01-01 false If I have a pre-existing dental or vision... MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL EMPLOYEES DENTAL AND VISION INSURANCE PROGRAM Administration and General Provisions § 894.102 If I have a pre-existing dental or vision...
5 CFR 894.102 - If I have a pre-existing dental or vision condition, may I join FEDVIP?
Code of Federal Regulations, 2010 CFR
2010-01-01
... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false If I have a pre-existing dental or vision... MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL EMPLOYEES DENTAL AND VISION INSURANCE PROGRAM Administration and General Provisions § 894.102 If I have a pre-existing dental or vision...
5 CFR 894.102 - If I have a pre-existing dental or vision condition, may I join FEDVIP?
Code of Federal Regulations, 2011 CFR
2011-01-01
... 5 Administrative Personnel 2 2011-01-01 2011-01-01 false If I have a pre-existing dental or vision... MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL EMPLOYEES DENTAL AND VISION INSURANCE PROGRAM Administration and General Provisions § 894.102 If I have a pre-existing dental or vision...
Racial Inequality Trends and the Intergenerational Persistence of Income and Family Structure
Bloome, Deirdre
2015-01-01
Racial disparity in family incomes remained remarkably stable over the past 40 years in the United States despite major legal and social reforms. Previous scholarship presents two primary explanations for persistent inequality through a period of progressive change. One highlights continuity: because socioeconomic status is transmitted from parents to children, disparities created through histories of discrimination and opportunity denial may dissipate slowly. The second highlights change: because family income results from joining individual earnings in family units, changing family compositions can offset individuals’ changing economic chances. I examine whether black-white family income inequality trends are better characterized by the persistence of existing disadvantage (continuity) or shifting forms of disadvantage (change). I combine cross-sectional and panel analysis using Current Population Survey, Panel Study of Income Dynamics, Census, and National Vital Statistics data. Results suggest that African Americans experience relatively extreme intergenerational continuity (low upward mobility) and discontinuity (high downward mobility); both helped maintain racial inequality. Yet, intergenerational discontinuities allow new forms of disadvantage to emerge. On net, racial inequality trends are better characterized by changing forms of disadvantage than by continuity. Economic trends were equalizing but demographic trends were disequalizing; as family structures shifted, family incomes did not fully reflect labor-market gains. PMID:26456973
Smoking cessation and subsequent weight change.
Robertson, Lindsay; McGee, Rob; Hancox, Robert J
2014-06-01
People who quit smoking tend to gain more weight over time than those who continue to smoke. Previous research using clinical samples of smokers suggests that quitters typically experience a weight gain of approximately 5 kg in the year following smoking cessation, but these studies may overestimate the extent of weight gain in the general population. The existing population-based research in this area has some methodological limitations. We assessed a cohort of individuals born in Dunedin, New Zealand, between 1972-1973 at regular intervals from age 15 to 38. We used multiple linear regression analysis to investigate the association between smoking cessation at ages 21 years to 38 years and subsequent change in body mass index (BMI) and weight, controlling for baseline BMI, socioeconomic status, physical activity, alcohol use, and parity (women). Smoking status and outcome data were available at baseline and at follow-up for 914 study members. People who smoked at age 21 and who had quit by age 38 had a BMI on average 1.5 kg/m(2) greater than those who continued to smoke at age 38. This equated to a weight gain of approximately 5.7 kg in men and 5.1 kg in women above that of continuing smokers. However, the weight gain between age 21 and 38 among quitters was not significantly different to that of never-smokers. The amount of long-term weight gained after quitting smoking is likely to be lower than previous estimates based on research with clinical samples. On average, quitters do not experience greater weight gain than never-smokers.
Local Existence of MHD Contact Discontinuities
NASA Astrophysics Data System (ADS)
Morando, Alessandro; Trakhinin, Yuri; Trebeschi, Paola
2018-05-01
We prove the local-in-time existence of solutions with a contact discontinuity of the equations of ideal compressible magnetohydrodynamics (MHD) for two dimensional planar flows provided that the Rayleigh-Taylor sign condition {[partial p/partial N] <0 } on the jump of the normal derivative of the pressure is satisfied at each point of the initial discontinuity. MHD contact discontinuities are characteristic discontinuities with no flow across the discontinuity for which the pressure, the magnetic field and the velocity are continuous whereas the density and the entropy may have a jump. This paper is a natural completion of our previous analysis (Morando et al. in J Differ Equ 258:2531-2571, 2015) where the well-posedness in Sobolev spaces of the linearized problem was proved under the Rayleigh-Taylor sign condition satisfied at each point of the unperturbed discontinuity. The proof of the resolution of the nonlinear problem given in the present paper follows from a suitable tame a priori estimate in Sobolev spaces for the linearized equations and a Nash-Moser iteration.
Retrofitting existing chemical scrubbers to biotrickling filters for H2S emission control
Gabriel, David; Deshusses, Marc A.
2003-01-01
Biological treatment is a promising alternative to conventional air-pollution control methods, but thus far biotreatment processes for odor control have always required much larger reactor volumes than chemical scrubbers. We converted an existing full-scale chemical scrubber to a biological trickling filter and showed that effective treatment of hydrogen sulfide (H2S) in the converted scrubber was possible even at gas contact times as low as 1.6 s. That is 8–20 times shorter than previous biotrickling filtration reports and comparable to usual contact times in chemical scrubbers. Significant removal of reduced sulfur compounds, ammonia, and volatile organic compounds present in traces in the air was also observed. Continuous operation for >8 months showed stable performance and robust behavior for H2S treatment, with pollutant-removal performance comparable to that achieved by using a chemical scrubber. Our study demonstrates that biotrickling filters can replace chemical scrubbers and be a safer, more economical technique for odor control. PMID:12740445
Retrofitting existing chemical scrubbers to biotrickling filters for H2S emission control.
Gabriel, David; Deshusses, Marc A
2003-05-27
Biological treatment is a promising alternative to conventional air-pollution control methods, but thus far biotreatment processes for odor control have always required much larger reactor volumes than chemical scrubbers. We converted an existing full-scale chemical scrubber to a biological trickling filter and showed that effective treatment of hydrogen sulfide (H2S) in the converted scrubber was possible even at gas contact times as low as 1.6 s. That is 8-20 times shorter than previous biotrickling filtration reports and comparable to usual contact times in chemical scrubbers. Significant removal of reduced sulfur compounds, ammonia, and volatile organic compounds present in traces in the air was also observed. Continuous operation for >8 months showed stable performance and robust behavior for H2S treatment, with pollutant-removal performance comparable to that achieved by using a chemical scrubber. Our study demonstrates that biotrickling filters can replace chemical scrubbers and be a safer, more economical technique for odor control.
Dynamical analysis of a cubic Liénard system with global parameters (II)
NASA Astrophysics Data System (ADS)
Chen, Hebai; Chen, Xingwu
2016-06-01
In this paper, we continue to study the global dynamics of a cubic Liénard system for global parameters in the case of three equilibria to follow (2015 Nonlinearity 28 3535-62), which deals with the case of two equilibria. We first analyse qualitative properties of all equilibria and judge the existences of limit cycles and homoclinic loops and their numbers. Then we obtain the bifurcation diagram and all phase portraits as our main results. Based on these results, in the case of three equilibria a positive answer to conjecture 3.2 of (1998 Nonlinearity 11 1505-19), which is about the existence of some function whose graph is exactly the surface of double limit cycles, is obtained. Moreover, a parameter region for the nonexistence of figure-eight loops is given theoretically to compensate for previous numerical results and is illustrated numerically. Supported by NSFC 11471228, 11572263, the Fundamental Research Funds for the Central Universities and Cultivation Foundation of Excellent Doctoral Dissertation of Southwest Jiaotong University (2015).
Advantage of hole stimulus in rivalry competition.
Meng, Qianli; Cui, Ding; Zhou, Ke; Chen, Lin; Ma, Yuanye
2012-01-01
Mounting psychophysical evidence suggests that early visual computations are sensitive to the topological properties of stimuli, such as the determination of whether the object has a hole or not. Previous studies have demonstrated that the hole feature took some advantages during conscious perception. In this study, we investigate whether there exists a privileged processing for hole stimuli during unconscious perception. By applying a continuous flash suppression paradigm, the target was gradually introduced to one eye to compete against a flashed full contrast Mondrian pattern which was presented to the other eye. This method ensured that the target image was suppressed during the initial perceptual period. We compared the initial suppressed duration between the stimuli with and without the hole feature and found that hole stimuli required less time than no-hole stimuli to gain dominance against the identical suppression noise. These results suggest the hole feature could be processed in the absence of awareness, and there exists a privileged detection of hole stimuli during suppressed phase in the interocular rivalry.
Quantifying killing of orangutans and human-orangutan conflict in Kalimantan, Indonesia.
Meijaard, Erik; Buchori, Damayanti; Hadiprakarsa, Yokyok; Utami-Atmoko, Sri Suci; Nurcahyo, Anton; Tjiu, Albertus; Prasetyo, Didik; Nardiyono; Christie, Lenny; Ancrenaz, Marc; Abadi, Firman; Antoni, I Nyoman Gede; Armayadi, Dedy; Dinato, Adi; Ella; Gumelar, Pajar; Indrawan, Tito P; Kussaritano; Munajat, Cecep; Priyono, C Wawan Puji; Purwanto, Yadi; Puspitasari, Dewi; Putra, M Syukur Wahyu; Rahmat, Abdi; Ramadani, Harri; Sammy, Jim; Siswanto, Dedi; Syamsuri, Muhammad; Andayani, Noviar; Wu, Huanhuan; Wells, Jessie Anne; Mengersen, Kerrie
2011-01-01
Human-orangutan conflict and hunting are thought to pose a serious threat to orangutan existence in Kalimantan, the Indonesian part of Borneo. No data existed prior to the present study to substantiate these threats. We investigated the rates, spatial distribution and causes of conflict and hunting through an interview-based survey in the orangutan's range in Kalimantan, Indonesia. Between April 2008 and September 2009, we interviewed 6983 respondents in 687 villages to obtain socio-economic information, assess knowledge of local wildlife in general and orangutan encounters specifically, and to query respondents about their knowledge on orangutan conflicts and killing, and relevant laws. This survey revealed estimated killing rates of between 750 and 1800 animals killed in the last year, and between 1950 and 3100 animals killed per year on average within the lifetime of the survey respondents. These killing rates are higher than previously thought and are high enough to pose a serious threat to the continued existence of orangutans in Kalimantan. Importantly, the study contributes to our understanding of the spatial variation in threats, and the underlying causes of those threats, which can be used to facilitate the development of targeted conservation management.
Quantifying Killing of Orangutans and Human-Orangutan Conflict in Kalimantan, Indonesia
Meijaard, Erik; Buchori, Damayanti; Hadiprakarsa, Yokyok; Utami-Atmoko, Sri Suci; Nurcahyo, Anton; Tjiu, Albertus; Prasetyo, Didik; Nardiyono; Christie, Lenny; Ancrenaz, Marc; Abadi, Firman; Antoni, I Nyoman Gede; Armayadi, Dedy; Dinato, Adi; Ella; Gumelar, Pajar; Indrawan, Tito P.; Kussaritano; Munajat, Cecep; Priyono, C. Wawan Puji; Purwanto, Yadi; Puspitasari, Dewi; Putra, M. Syukur Wahyu; Rahmat, Abdi; Ramadani, Harri; Sammy, Jim; Siswanto, Dedi; Syamsuri, Muhammad; Andayani, Noviar; Wu, Huanhuan; Wells, Jessie Anne; Mengersen, Kerrie
2011-01-01
Human-orangutan conflict and hunting are thought to pose a serious threat to orangutan existence in Kalimantan, the Indonesian part of Borneo. No data existed prior to the present study to substantiate these threats. We investigated the rates, spatial distribution and causes of conflict and hunting through an interview-based survey in the orangutan's range in Kalimantan, Indonesia. Between April 2008 and September 2009, we interviewed 6983 respondents in 687 villages to obtain socio-economic information, assess knowledge of local wildlife in general and orangutan encounters specifically, and to query respondents about their knowledge on orangutan conflicts and killing, and relevant laws. This survey revealed estimated killing rates of between 750 and 1800 animals killed in the last year, and between 1950 and 3100 animals killed per year on average within the lifetime of the survey respondents. These killing rates are higher than previously thought and are high enough to pose a serious threat to the continued existence of orangutans in Kalimantan. Importantly, the study contributes to our understanding of the spatial variation in threats, and the underlying causes of those threats, which can be used to facilitate the development of targeted conservation management. PMID:22096582
[Root resorption associated to orthodontic treatment: a clinical case].
Houb-Dine, Afaf; Rerhrhaye, Mariam; Ismaili, Zouheir; Rerhrhaye, Wiam
2011-12-01
Root resorption associated to orthodontic treatment is of multiple etiologies and a non intentional iatrogenic side effect which exists in almost all the orthodontic treatment. This clinical case of an apparently healthy patient illustrates the occurrence during the orthodontic treatment of a root resorption interesting the left central incisor, victims of previous traumatism and presenting a moderate periodontal attachment loss. The orthodontic treatment was carried out with light and continuous forces and a per-orthodontic periodontal maintenance in respect of periodontal requirements. As soon as the root resorption on the left central incisive was diagnosed, the active orthodontic treatment was interrupted in order to stabilize the lesion and a regular clinical and radiological monitoring was established.
NASA Astrophysics Data System (ADS)
Jitomirskaya, S.; Marx, C. A.
2012-11-01
We show how to extend (and with what limitations) Avila's global theory of analytic SL(2,C) cocycles to families of cocycles with singularities. This allows us to develop a strategy to determine the Lyapunov exponent for the extended Harper's model, for all values of parameters and all irrational frequencies. In particular, this includes the self-dual regime for which even heuristic results did not previously exist in physics literature. The extension of Avila's global theory is also shown to imply continuous behavior of the LE on the space of analytic {M_2({C})}-cocycles. This includes rational approximation of the frequency, which so far has not been available.
Previous Violent Events and Mental Health Outcomes in Guatemala
Puac-Polanco, Victor D.; Lopez-Soto, Victor A.; Kohn, Robert; Xie, Dawei; Richmond, Therese S.
2015-01-01
Objectives. We analyzed a probability sample of Guatemalans to determine if a relationship exists between previous violent events and development of mental health outcomes in various sociodemographic groups, as well as during and after the Guatemalan Civil War. Methods. We used regression modeling, an interaction test, and complex survey design adjustments to estimate prevalences and test potential relationships between previous violent events and mental health. Results. Many (20.6%) participants experienced at least 1 previous serious violent event. Witnessing someone severely injured or killed was the most common event. Depression was experienced by 4.2% of participants, with 6.5% experiencing anxiety, 6.4% an alcohol-related disorder, and 1.9% posttraumatic stress disorder (PTSD). Persons who experienced violence during the war had 4.3 times the adjusted odds of alcohol-related disorders (P < .05) and 4.0 times the adjusted odds of PTSD (P < .05) compared with the postwar period. Women, indigenous Maya, and urban dwellers had greater odds of experiencing postviolence mental health outcomes. Conclusions. Violence that began during the civil war and continues today has had a significant effect on the mental health of Guatemalans. However, mental health outcomes resulting from violent events decreased in the postwar period, suggesting a nation in recovery. PMID:25713973
40 CFR 427.54 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Pretreatment standards for existing sources. 427.54 Section 427.54 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos...
40 CFR 427.54 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 31 2013-07-01 2013-07-01 false Pretreatment standards for existing sources. 427.54 Section 427.54 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos...
40 CFR 427.54 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Pretreatment standards for existing sources. 427.54 Section 427.54 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos...
12 CFR 152.13 - Combinations involving Federal stock associations.
Code of Federal Regulations, 2012 CFR
2012-01-01
... resulting depository institution, which retains its corporate identity. (7) Mutual savings association. Any... depository institution whose corporate existence does not continue after a combination. (6) Merger. Uniting.... (8) Resulting institution. The depository institution whose corporate existence continues after a...
12 CFR 552.13 - Combinations involving Federal stock associations.
Code of Federal Regulations, 2014 CFR
2014-01-01
... resulting depository institution, which retains its corporate identity. (7) Mutual savings association. Any... depository institution whose corporate existence does not continue after a combination. (6) Merger. Uniting.... (8) Resulting institution. The depository institution whose corporate existence continues after a...
12 CFR 552.13 - Combinations involving Federal stock associations.
Code of Federal Regulations, 2011 CFR
2011-01-01
... resulting depository institution, which retains its corporate identity. (7) Mutual savings association. Any... depository institution whose corporate existence does not continue after a combination. (6) Merger. Uniting.... (8) Resulting institution. The depository institution whose corporate existence continues after a...
12 CFR 552.13 - Combinations involving Federal stock associations.
Code of Federal Regulations, 2013 CFR
2013-01-01
... resulting depository institution, which retains its corporate identity. (7) Mutual savings association. Any... depository institution whose corporate existence does not continue after a combination. (6) Merger. Uniting.... (8) Resulting institution. The depository institution whose corporate existence continues after a...
12 CFR 152.13 - Combinations involving Federal stock associations.
Code of Federal Regulations, 2013 CFR
2013-01-01
... resulting depository institution, which retains its corporate identity. (7) Mutual savings association. Any... depository institution whose corporate existence does not continue after a combination. (6) Merger. Uniting.... (8) Resulting institution. The depository institution whose corporate existence continues after a...
12 CFR 152.13 - Combinations involving Federal stock associations.
Code of Federal Regulations, 2014 CFR
2014-01-01
... resulting depository institution, which retains its corporate identity. (7) Mutual savings association. Any... depository institution whose corporate existence does not continue after a combination. (6) Merger. Uniting.... (8) Resulting institution. The depository institution whose corporate existence continues after a...
12 CFR 552.13 - Combinations involving Federal stock associations.
Code of Federal Regulations, 2012 CFR
2012-01-01
... resulting depository institution, which retains its corporate identity. (7) Mutual savings association. Any... depository institution whose corporate existence does not continue after a combination. (6) Merger. Uniting.... (8) Resulting institution. The depository institution whose corporate existence continues after a...
Cardiovascular studies using the chimpanzee (Pan troglodytes)
NASA Technical Reports Server (NTRS)
Hinds, J. E.; Cothran, L. N.; Hawthorne, E. W.
1977-01-01
Despite the phylogenetic similarities between chimpanzees and man, there exists a paucity of reliable data on normal cardiovascular function and the physiological responses of the system to standard interventions. Totally implanted biotelemetry systems or hardwire analog techniques were used to examine the maximum number of cardiovascular variables which could be simultaneously monitored without significantly altering the system's performance. This was performed in order to acquire base-line data not previously obtained in this species, to determine cardiovascular response to specific forcing functions such as ventricular pacing, drug infusions, and lower body negative pressure. A cardiovascular function profile protocol was developed in order to adjust independently the three major factors which modify ventricular performance, namely, left ventricular performance, left ventricular preload, afterload, and contractility. Cardiac pacing at three levels above the ambient rate was used to adjust end diastolic volume (preload). Three concentrations of angiotensin were infused continuously to evaluate afterload in a stepwide fashion. A continuous infusion of dobutamine was administered to raise the manifest contractile state of the heart.
Chen, Rui; Hyrien, Ollivier
2011-01-01
This article deals with quasi- and pseudo-likelihood estimation in a class of continuous-time multi-type Markov branching processes observed at discrete points in time. “Conventional” and conditional estimation are discussed for both approaches. We compare their properties and identify situations where they lead to asymptotically equivalent estimators. Both approaches possess robustness properties, and coincide with maximum likelihood estimation in some cases. Quasi-likelihood functions involving only linear combinations of the data may be unable to estimate all model parameters. Remedial measures exist, including the resort either to non-linear functions of the data or to conditioning the moments on appropriate sigma-algebras. The method of pseudo-likelihood may also resolve this issue. We investigate the properties of these approaches in three examples: the pure birth process, the linear birth-and-death process, and a two-type process that generalizes the previous two examples. Simulations studies are conducted to evaluate performance in finite samples. PMID:21552356
Integrate-and-fire models with an almost periodic input function
NASA Astrophysics Data System (ADS)
Kasprzak, Piotr; Nawrocki, Adam; Signerska-Rynkowska, Justyna
2018-02-01
We investigate leaky integrate-and-fire models (LIF models for short) driven by Stepanov and μ-almost periodic functions. Special attention is paid to the properties of the firing map and its displacement, which give information about the spiking behavior of the considered system. We provide conditions under which such maps are well-defined and are uniformly continuous. We show that the LIF models with Stepanov almost periodic inputs have uniformly almost periodic displacements. We also show that in the case of μ-almost periodic drives it may happen that the displacement map is uniformly continuous, but is not μ-almost periodic (and thus cannot be Stepanov or uniformly almost periodic). By allowing discontinuous inputs, we extend some previous results, showing, for example, that the firing rate for the LIF models with Stepanov almost periodic input exists and is unique. This is a starting point for the investigation of the dynamics of almost-periodically driven integrate-and-fire systems.
Calibration of the head direction network: a role for symmetric angular head velocity cells.
Stratton, Peter; Wyeth, Gordon; Wiles, Janet
2010-06-01
Continuous attractor networks require calibration. Computational models of the head direction (HD) system of the rat usually assume that the connections that maintain HD neuron activity are pre-wired and static. Ongoing activity in these models relies on precise continuous attractor dynamics. It is currently unknown how such connections could be so precisely wired, and how accurate calibration is maintained in the face of ongoing noise and perturbation. Our adaptive attractor model of the HD system that uses symmetric angular head velocity (AHV) cells as a training signal shows that the HD system can learn to support stable firing patterns from poorly-performing, unstable starting conditions. The proposed calibration mechanism suggests a requirement for symmetric AHV cells, the existence of which has previously been unexplained, and predicts that symmetric and asymmetric AHV cells should be distinctly different (in morphology, synaptic targets and/or methods of action on postsynaptic HD cells) due to their distinctly different functions.
Wang, Dongshu; Huang, Lihong
2014-03-01
In this paper, we investigate the periodic dynamical behaviors for a class of general Cohen-Grossberg neural networks with discontinuous right-hand sides, time-varying and distributed delays. By means of retarded differential inclusions theory and the fixed point theorem of multi-valued maps, the existence of periodic solutions for the neural networks is obtained. After that, we derive some sufficient conditions for the global exponential stability and convergence of the neural networks, in terms of nonsmooth analysis theory with generalized Lyapunov approach. Without assuming the boundedness (or the growth condition) and monotonicity of the discontinuous neuron activation functions, our results will also be valid. Moreover, our results extend previous works not only on discrete time-varying and distributed delayed neural networks with continuous or even Lipschitz continuous activations, but also on discrete time-varying and distributed delayed neural networks with discontinuous activations. We give some numerical examples to show the applicability and effectiveness of our main results. Copyright © 2013 Elsevier Ltd. All rights reserved.
Calibrating cellular automaton models for pedestrians walking through corners
NASA Astrophysics Data System (ADS)
Dias, Charitha; Lovreglio, Ruggiero
2018-05-01
Cellular Automata (CA) based pedestrian simulation models have gained remarkable popularity as they are simpler and easier to implement compared to other microscopic modeling approaches. However, incorporating traditional floor field representations in CA models to simulate pedestrian corner navigation behavior could result in unrealistic behaviors. Even though several previous studies have attempted to enhance CA models to realistically simulate pedestrian maneuvers around bends, such modifications have not been calibrated or validated against empirical data. In this study, two static floor field (SFF) representations, namely 'discrete representation' and 'continuous representation', are calibrated for CA-models to represent pedestrians' walking behavior around 90° bends. Trajectory data collected through a controlled experiment are used to calibrate these model representations. Calibration results indicate that although both floor field representations can represent pedestrians' corner navigation behavior, the 'continuous' representation fits the data better. Output of this study could be beneficial for enhancing the reliability of existing CA-based models by representing pedestrians' corner navigation behaviors more realistically.
14 CFR 60.17 - Previously qualified FSTDs.
Code of Federal Regulations, 2014 CFR
2014-01-01
... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false Previously qualified FSTDs. 60.17 Section 60.17 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN FLIGHT SIMULATION TRAINING DEVICE INITIAL AND CONTINUING QUALIFICATION AND USE § 60.17 Previously...
14 CFR 60.17 - Previously qualified FSTDs.
Code of Federal Regulations, 2012 CFR
2012-01-01
... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Previously qualified FSTDs. 60.17 Section 60.17 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN FLIGHT SIMULATION TRAINING DEVICE INITIAL AND CONTINUING QUALIFICATION AND USE § 60.17 Previously...
14 CFR 60.17 - Previously qualified FSTDs.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Previously qualified FSTDs. 60.17 Section 60.17 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN FLIGHT SIMULATION TRAINING DEVICE INITIAL AND CONTINUING QUALIFICATION AND USE § 60.17 Previously...
14 CFR 60.17 - Previously qualified FSTDs.
Code of Federal Regulations, 2013 CFR
2013-01-01
... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Previously qualified FSTDs. 60.17 Section 60.17 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN FLIGHT SIMULATION TRAINING DEVICE INITIAL AND CONTINUING QUALIFICATION AND USE § 60.17 Previously...
14 CFR 60.17 - Previously qualified FSTDs.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Previously qualified FSTDs. 60.17 Section 60.17 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN FLIGHT SIMULATION TRAINING DEVICE INITIAL AND CONTINUING QUALIFICATION AND USE § 60.17 Previously...
Uncountably many maximizing measures for a dense subset of continuous functions
NASA Astrophysics Data System (ADS)
Shinoda, Mao
2018-05-01
Ergodic optimization aims to single out dynamically invariant Borel probability measures which maximize the integral of a given ‘performance’ function. For a continuous self-map of a compact metric space and a dense set of continuous functions, we show the existence of uncountably many ergodic maximizing measures. We also show that, for a topologically mixing subshift of finite type and a dense set of continuous functions there exist uncountably many ergodic maximizing measures with full support and positive entropy.
1,003 reference genomes of bacterial and archaeal isolates expand coverage of the tree of life
Mukherjee, Supratim; Seshadri, Rekha; Varghese, Neha J.; ...
2017-06-12
We present 1,003 reference genomes that were sequenced as part of the Genomic Encyclopedia of Bacteria and Archaea (GEBA) initiative, selected to maximize sequence coverage of phylogenetic space. These genomes double the number of existing type strains and expand their overall phylogenetic diversity by 25%. Comparative analyses with previously available finished and draft genomes reveal a 10.5% increase in novel protein families as a function of phylogenetic diversity. The GEBA genomes recruit 25 million previously unassigned metagenomic proteins from 4,650 samples, improving their phylogenetic and functional interpretation. We identify numerous biosynthetic clusters and experimentally validate a divergent phenazine cluster withmore » potential new chemical structure and antimicrobial activity. This Resource is the largest single release of reference genomes to date. Bacterial and archaeal isolate sequence space is still far from saturated, and future endeavors in this direction will continue to be a valuable resource for scientific discovery.« less
1,003 reference genomes of bacterial and archaeal isolates expand coverage of the tree of life
DOE Office of Scientific and Technical Information (OSTI.GOV)
Mukherjee, Supratim; Seshadri, Rekha; Varghese, Neha J.
We present 1,003 reference genomes that were sequenced as part of the Genomic Encyclopedia of Bacteria and Archaea (GEBA) initiative, selected to maximize sequence coverage of phylogenetic space. These genomes double the number of existing type strains and expand their overall phylogenetic diversity by 25%. Comparative analyses with previously available finished and draft genomes reveal a 10.5% increase in novel protein families as a function of phylogenetic diversity. The GEBA genomes recruit 25 million previously unassigned metagenomic proteins from 4,650 samples, improving their phylogenetic and functional interpretation. We identify numerous biosynthetic clusters and experimentally validate a divergent phenazine cluster withmore » potential new chemical structure and antimicrobial activity. This Resource is the largest single release of reference genomes to date. Bacterial and archaeal isolate sequence space is still far from saturated, and future endeavors in this direction will continue to be a valuable resource for scientific discovery.« less
From empirical data to time-inhomogeneous continuous Markov processes.
Lencastre, Pedro; Raischel, Frank; Rogers, Tim; Lind, Pedro G
2016-03-01
We present an approach for testing for the existence of continuous generators of discrete stochastic transition matrices. Typically, existing methods to ascertain the existence of continuous Markov processes are based on the assumption that only time-homogeneous generators exist. Here a systematic extension to time inhomogeneity is presented, based on new mathematical propositions incorporating necessary and sufficient conditions, which are then implemented computationally and applied to numerical data. A discussion concerning the bridging between rigorous mathematical results on the existence of generators to its computational implementation is presented. Our detection algorithm shows to be effective in more than 60% of tested matrices, typically 80% to 90%, and for those an estimate of the (nonhomogeneous) generator matrix follows. We also solve the embedding problem analytically for the particular case of three-dimensional circulant matrices. Finally, a discussion of possible applications of our framework to problems in different fields is briefly addressed.
NASA Astrophysics Data System (ADS)
Dent, Paul; Tun, Sai Han; Fillioe, Seth; Deng, Bin; Satalin, Josh; Nieman, Gary; Wilcox, Kailyn; Searles, Quinn; Narsipur, Sri; Peterson, Charles M.; Goodisman, Jerry; Mostrom, James; Steinmann, Richard; Chaiken, J.
2018-02-01
We previously reported a new algorithm "PV[O]H" for continuous, noninvasive, in vivo monitoring of hematocrit changes in blood and have since shown its utility for monitoring in humans during 1) hemodialysis, 2) orthostatic perturbations and 3) during blood loss and fluid replacement in a rat model. We now show that the algorithm is sensitive to changes in hemoglobin oxygen saturation. We document the phenomenology of the effect and explain the effect using new results obtained from humans and rat models. The oxygen sensitivity derives from the differential absorption of autofluorescence originating in the static tissues by oxy and deoxy hemoglobin. Using this approach we show how to perform simultaneous, noninvasive, in vivo, continuous monitoring of hematocrit, vascular volume, hemoglobin oxygen saturation, pulse rate and breathing rate in mammals using a single light source. We suspect that monitoring of changes in this suite of vital signs can be provided with improved time response, sensitivity and precision compared to existing methodologies. Initial results also offer a more detailed glimpse into the systemic oxygen transport in the circulatory system of humans.
Effects of diffusion on total biomass in heterogeneous continuous and discrete-patch systems
DeAngelis, Donald L.; Ming Ni, Wei; Zhang, Bo
2016-01-01
Theoretical models of populations on a system of two connected patches previously have shown that when the two patches differ in maximum growth rate and carrying capacity, and in the limit of high diffusion, conditions exist for which the total population size at equilibrium exceeds that of the ideal free distribution, which predicts that the total population would equal the total carrying capacity of the two patches. However, this result has only been shown for the Pearl-Verhulst growth function on two patches and for a single-parameter growth function in continuous space. Here, we provide a general criterion for total population size to exceed total carrying capacity for three commonly used population growth rates for both heterogeneous continuous and multi-patch heterogeneous landscapes with high population diffusion. We show that a sufficient condition for this situation is that there is a convex positive relationship between the maximum growth rate and the parameter that, by itself or together with the maximum growth rate, determines the carrying capacity, as both vary across a spatial region. This relationship occurs in some biological populations, though not in others, so the result has ecological implications.
Improved HDRG decoders for qudit and non-Abelian quantum error correction
NASA Astrophysics Data System (ADS)
Hutter, Adrian; Loss, Daniel; Wootton, James R.
2015-03-01
Hard-decision renormalization group (HDRG) decoders are an important class of decoding algorithms for topological quantum error correction. Due to their versatility, they have been used to decode systems with fractal logical operators, color codes, qudit topological codes, and non-Abelian systems. In this work, we develop a method of performing HDRG decoding which combines strengths of existing decoders and further improves upon them. In particular, we increase the minimal number of errors necessary for a logical error in a system of linear size L from \\Theta ({{L}2/3}) to Ω ({{L}1-ε }) for any ε \\gt 0. We apply our algorithm to decoding D({{{Z}}d}) quantum double models and a non-Abelian anyon model with Fibonacci-like fusion rules, and show that it indeed significantly outperforms previous HDRG decoders. Furthermore, we provide the first study of continuous error correction with imperfect syndrome measurements for the D({{{Z}}d}) quantum double models. The parallelized runtime of our algorithm is poly(log L) for the perfect measurement case. In the continuous case with imperfect syndrome measurements, the averaged runtime is O(1) for Abelian systems, while continuous error correction for non-Abelian anyons stays an open problem.
40 CFR 427.64 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Pretreatment standards for existing sources. 427.64 Section 427.64 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos Roofing...
40 CFR 427.34 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Pretreatment standards for existing sources. 427.34 Section 427.34 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos Paper...
40 CFR 427.74 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Pretreatment standards for existing sources. 427.74 Section 427.74 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos Floor...
40 CFR 427.34 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 31 2013-07-01 2013-07-01 false Pretreatment standards for existing sources. 427.34 Section 427.34 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos Paper...
40 CFR 427.64 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 31 2013-07-01 2013-07-01 false Pretreatment standards for existing sources. 427.64 Section 427.64 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos Roofing...
40 CFR 427.44 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Pretreatment standards for existing sources. 427.44 Section 427.44 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos Paper...
40 CFR 427.74 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Pretreatment standards for existing sources. 427.74 Section 427.74 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos Floor...
40 CFR 427.24 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Pretreatment standards for existing sources. 427.24 Section 427.24 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos-Cement...
40 CFR 427.14 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Pretreatment standards for existing sources. 427.14 Section 427.14 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos-Cement...
40 CFR 427.14 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 31 2013-07-01 2013-07-01 false Pretreatment standards for existing sources. 427.14 Section 427.14 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos-Cement...
40 CFR 427.64 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Pretreatment standards for existing sources. 427.64 Section 427.64 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos Roofing...
40 CFR 427.14 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Pretreatment standards for existing sources. 427.14 Section 427.14 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos-Cement...
40 CFR 427.44 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Pretreatment standards for existing sources. 427.44 Section 427.44 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos Paper...
40 CFR 427.24 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 31 2013-07-01 2013-07-01 false Pretreatment standards for existing sources. 427.24 Section 427.24 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos-Cement...
40 CFR 427.24 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Pretreatment standards for existing sources. 427.24 Section 427.24 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos-Cement...
40 CFR 427.74 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 31 2013-07-01 2013-07-01 false Pretreatment standards for existing sources. 427.74 Section 427.74 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos Floor...
40 CFR 427.44 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 31 2013-07-01 2013-07-01 false Pretreatment standards for existing sources. 427.44 Section 427.44 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos Paper...
40 CFR 427.34 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Pretreatment standards for existing sources. 427.34 Section 427.34 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos Paper...
40 CFR 463.35 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Pretreatment standards for existing sources. 463.35 Section 463.35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) PLASTICS MOLDING AND FORMING POINT SOURCE CATEGORY Finishing...
40 CFR 463.25 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Pretreatment standards for existing sources. 463.25 Section 463.25 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) PLASTICS MOLDING AND FORMING POINT SOURCE CATEGORY Cleaning...
40 CFR 463.15 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Pretreatment standards for existing sources. 463.15 Section 463.15 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) PLASTICS MOLDING AND FORMING POINT SOURCE CATEGORY Contact...
40 CFR 439.46 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Pretreatment standards for existing sources (PSES). 439.46 Section 439.46 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) PHARMACEUTICAL MANUFACTURING POINT SOURCE CATEGORY Mixing...
40 CFR 426.64 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Pretreatment standards for existing sources. 426.64 Section 426.64 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) GLASS MANUFACTURING POINT SOURCE CATEGORY Automotive Glass...
40 CFR 426.64 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 31 2013-07-01 2013-07-01 false Pretreatment standards for existing sources. 426.64 Section 426.64 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) GLASS MANUFACTURING POINT SOURCE CATEGORY Automotive Glass...
40 CFR 461.64 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Pretreatment standards for existing sources (PSES). 461.64 Section 461.64 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) BATTERY MANUFACTURING POINT SOURCE CATEGORY Magnesium...
40 CFR 455.26 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 31 2013-07-01 2013-07-01 false Pretreatment standards for existing sources (PSES). 455.26 Section 455.26 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) PESTICIDE CHEMICALS Organic Pesticide Chemicals Manufacturing...
40 CFR 455.26 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Pretreatment standards for existing sources (PSES). 455.26 Section 455.26 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) PESTICIDE CHEMICALS Organic Pesticide Chemicals Manufacturing...
40 CFR 463.25 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Pretreatment standards for existing sources. 463.25 Section 463.25 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) PLASTICS MOLDING AND FORMING POINT SOURCE CATEGORY Cleaning...
40 CFR 463.15 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Pretreatment standards for existing sources. 463.15 Section 463.15 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) PLASTICS MOLDING AND FORMING POINT SOURCE CATEGORY Contact...
40 CFR 463.35 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Pretreatment standards for existing sources. 463.35 Section 463.35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) PLASTICS MOLDING AND FORMING POINT SOURCE CATEGORY Finishing...
40 CFR 63.1157 - Emission standards for existing sources.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 11 2014-07-01 2014-07-01 false Emission standards for existing... PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Steel Pickling-HCl Process...
Heiferman, Daniel M; Billingsley, Joshua T; Kasliwal, Manish K; Johnson, Andrew K; Keigher, Kiffon M; Frudit, Michel E; Moftakhar, Roham; Lopes, Demetrius K
2016-07-01
Flow-diverting stents, including the Pipeline embolization device (PED) and Silk, have been beneficial in the treatment of aneurysms previously unable to be approached via endovascular techniques. Recurrent aneurysms for which stent-assisted embolization has failed are a therapeutic challenge, given the existing intraluminal construct with continued blood flow into the aneurysm. We report our experience using flow-diverting stents in the repair of 25 aneurysms for which stent-assisted embolization had failed. Nineteen (76%) of these aneurysms at the 12-month follow-up showed improved Raymond class occlusion, with 38% being completely occluded, and all aneurysms demonstrated decreased filling. One patient developed a moderate permanent neurologic deficit. Appropriate stent sizing, proximal and distal construct coverage, and preventing flow diverter deployment between the previously deployed stent struts are important considerations to ensure wall apposition and prevention of endoleak. Flow diverters are shown to be a reasonable option for treating previously stented recurrent cerebral aneurysms. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/
NASA Astrophysics Data System (ADS)
Xi, Songnan; Zoltowski, Michael D.
2008-04-01
Multiuser multiple-input multiple-output (MIMO) systems are considered in this paper. We continue our research on uplink transmit beamforming design for multiple users under the assumption that the full multiuser channel state information, which is the collection of the channel state information between each of the users and the base station, is known not only to the receiver but also to all the transmitters. We propose an algorithm for designing optimal beamforming weights in terms of maximizing the signal-to-interference-plus-noise ratio (SINR). Through statistical modeling, we decouple the original mathematically intractable optimization problem and achieved a closed-form solution. As in our previous work, the minimum mean-squared error (MMSE) receiver with successive interference cancellation (SIC) is adopted for multiuser detection. The proposed scheme is compared with an existing jointly optimized transceiver design, referred to as the joint transceiver in this paper, and our previously proposed eigen-beamforming algorithm. Simulation results demonstrate that our algorithm, with much less computational burden, accomplishes almost the same performance as the joint transceiver for spatially independent MIMO channel and even better performance for spatially correlated MIMO channels. And it always works better than our previously proposed eigen beamforming algorithm.
[Fertility and characteristics of ovulation after discontinuing oral contraception].
Gaspard, U; Lambotte, R
1984-09-01
A brief review of the literature is the basis for this discussion of residual effects of oral contraceptives (OCs) on fertility and the quality of ovulation after pill use is terminated. A 1982 study of the delay to conception attempted to avoid methological difficulties of earlier studies by comparing previous contraceptive usage among 7000 women hospitalized for childbirth. The analysis showed that the monthly percentage of pregnancies after OC use was significantly decreased for the 1st 3 months compared to levels in former IUD and diaphragm users. 13 months after OCs, 24.8% of OC users still had not conceived, compared to 12.4% if IUD and 8.5% of diaphragm users. Post-pill amenorrhea of longer than 6 months occurs in about 1% of cases. It is now agreed that post-pill amenorrhea is rare, nonspecific, and of multifactorial etiology. The previous existence of menstrual irregularity, stress, psychological troubles, malnutrition, and anorexia are particularly significant. OC use seems to mask the natural occurrence of secondary amenorrhea rather than to cause it. The most careful of available studies document that, although OC use may because of its estrogen content reveal an unsuspected prolactinemia, there is no increase in prolactinemia among OC users. A consensus exists that, excluding patients developing amenorrhea due to ovarian insufficiency, post-pill amenorrhea responds to ovulation inducing treatment exactly as do amenorrheas with no history of pill use. In cases of conception after failure of OCs and continued treatment with OCs, the aging of sperm or hypermaturation of ova at the time of fertilization is accompanied by a very slight increase in the proportion of male fetuses. The teratogenic risk appears to be negligable among former OC users and perhaps slightly greater if OCs, hormonal tests, or supplementary hormonal therapy are continued during pregnancy. The increased risk is not even seen in many studies and does not appear to indicate pregnancy termination as a general rule.
NASA Technical Reports Server (NTRS)
Thesken, John C.; Murthy, Pappu L. N.; Phoenix, S. L.; Greene, N.; Palko, Joseph L.; Eldridge, Jeffrey; Sutter, James; Saulsberry, R.; Beeson, H.
2009-01-01
A theoretical investigation of the factors controlling the stress rupture life of the National Aeronautics and Space Administration's (NASA) composite overwrapped pressure vessels (COPVs) continues. Kevlar (DuPont) fiber overwrapped tanks are of particular concern due to their long usage and the poorly understood stress rupture process in Kevlar filaments. Existing long term data show that the rupture process is a function of stress, temperature and time. However due to the presence of a load sharing liner, the manufacturing induced residual stresses and the complex mechanical response, the state of actual fiber stress in flight hardware and test articles is not clearly known. This paper is a companion to a previously reported experimental investigation and develops a theoretical framework necessary to design full-scale pathfinder experiments and accurately interpret the experimentally observed deformation and failure mechanisms leading up to static burst in COPVs. The fundamental mechanical response of COPVs is described using linear elasticity and thin shell theory and discussed in comparison to existing experimental observations. These comparisons reveal discrepancies between physical data and the current analytical results and suggest that the vessel s residual stress state and the spatial stress distribution as a function of pressure may be completely different from predictions based upon existing linear elastic analyses. The 3D elasticity of transversely isotropic spherical shells demonstrates that an overly compliant transverse stiffness relative to membrane stiffness can account for some of this by shifting a thin shell problem well into the realm of thick shell response. The use of calibration procedures are demonstrated as calibrated thin shell model results and finite element results are shown to be in good agreement with the experimental results. The successes reported here have lead to continuing work with full scale testing of larger NASA COPV hardware.
40 CFR 429.75 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 31 2013-07-01 2013-07-01 false Pretreatment standards for existing sources (PSES). 429.75 Section 429.75 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) TIMBER PRODUCTS PROCESSING POINT SOURCE CATEGORY Wood...
40 CFR 429.75 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Pretreatment standards for existing sources (PSES). 429.75 Section 429.75 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) TIMBER PRODUCTS PROCESSING POINT SOURCE CATEGORY Wood...
40 CFR 429.85 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Pretreatment standards for existing sources (PSES). 429.85 Section 429.85 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) TIMBER PRODUCTS PROCESSING POINT SOURCE CATEGORY Wood...
40 CFR 429.85 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 31 2013-07-01 2013-07-01 false Pretreatment standards for existing sources (PSES). 429.85 Section 429.85 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) TIMBER PRODUCTS PROCESSING POINT SOURCE CATEGORY Wood...
40 CFR 429.75 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Pretreatment standards for existing sources (PSES). 429.75 Section 429.75 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) TIMBER PRODUCTS PROCESSING POINT SOURCE CATEGORY Wood...
40 CFR 429.95 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Pretreatment standards for existing sources (PSES). 429.95 Section 429.95 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) TIMBER PRODUCTS PROCESSING POINT SOURCE CATEGORY Wood...
40 CFR 420.65 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 28 2010-07-01 2010-07-01 true Pretreatment standards for existing sources (PSES). 420.65 Section 420.65 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS IRON AND STEEL MANUFACTURING POINT SOURCE CATEGORY Continuous Casting...
32 CFR 651.38 - Existing environmental assessments.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 32 National Defense 4 2010-07-01 2010-07-01 true Existing environmental assessments. 651.38 Section 651.38 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) ENVIRONMENTAL QUALITY ENVIRONMENTAL ANALYSIS OF ARMY ACTIONS (AR 200-2) Environmental Assessment § 651.38...
40 CFR 455.36 - Pretreatment standards for existing sources (PSES). [Reserved
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Pretreatment standards for existing sources (PSES). [Reserved] 455.36 Section 455.36 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) PESTICIDE CHEMICALS Metallo-Organic Pesticide...
40 CFR 455.36 - Pretreatment standards for existing sources (PSES). [Reserved
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 31 2013-07-01 2013-07-01 false Pretreatment standards for existing sources (PSES). [Reserved] 455.36 Section 455.36 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) PESTICIDE CHEMICALS Metallo-Organic Pesticide...
40 CFR 455.36 - Pretreatment standards for existing sources (PSES). [Reserved
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Pretreatment standards for existing sources (PSES). [Reserved] 455.36 Section 455.36 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) PESTICIDE CHEMICALS Metallo-Organic Pesticide...
40 CFR 425.35 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Pretreatment standards for existing sources (PSES). 425.35 Section 425.35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) LEATHER TANNING AND FINISHING POINT SOURCE CATEGORY Hair Save...
40 CFR 425.15 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 31 2013-07-01 2013-07-01 false Pretreatment standards for existing sources (PSES). 425.15 Section 425.15 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) LEATHER TANNING AND FINISHING POINT SOURCE CATEGORY Hair Pulp...
40 CFR 425.15 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Pretreatment standards for existing sources (PSES). 425.15 Section 425.15 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) LEATHER TANNING AND FINISHING POINT SOURCE CATEGORY Hair Pulp...
40 CFR 425.15 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Pretreatment standards for existing sources (PSES). 425.15 Section 425.15 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) LEATHER TANNING AND FINISHING POINT SOURCE CATEGORY Hair Pulp...
40 CFR 425.25 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Pretreatment standards for existing sources (PSES). 425.25 Section 425.25 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) LEATHER TANNING AND FINISHING POINT SOURCE CATEGORY Hair Save...
40 CFR 425.25 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Pretreatment standards for existing sources (PSES). 425.25 Section 425.25 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) LEATHER TANNING AND FINISHING POINT SOURCE CATEGORY Hair Save...
40 CFR 425.35 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Pretreatment standards for existing sources (PSES). 425.35 Section 425.35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) LEATHER TANNING AND FINISHING POINT SOURCE CATEGORY Hair Save...
40 CFR 425.35 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 31 2013-07-01 2013-07-01 false Pretreatment standards for existing sources (PSES). 425.35 Section 425.35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) LEATHER TANNING AND FINISHING POINT SOURCE CATEGORY Hair Save...
40 CFR 425.25 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 31 2013-07-01 2013-07-01 false Pretreatment standards for existing sources (PSES). 425.25 Section 425.25 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) LEATHER TANNING AND FINISHING POINT SOURCE CATEGORY Hair Save...
An Experimental Study of n-Heptane and JP-7 Extinction Limits in an Opposed Jet Burner
NASA Technical Reports Server (NTRS)
Convery, Janet L.; Pellett, Gerald L.; O'Brien, Walter F., Jr.; Wilson, Lloyd G.; Williams, John
2005-01-01
Propulsion engine combustor design and analysis requires experimentally verified data on the chemical kinetics of fuel. Among the important data is the combustion extinction limit as measured by observed maximum flame strain rate. The extinction limit relates to the ability to maintain a flame in a combustor during operation. Extinction limit data can be obtained for a given fuel by means of a laminar flame experiment using an opposed jet burner (OJB). Laminar extinction limit data can be applied to the turbulent application of a combustor via laminar flamelet modeling. The OJB consists of two axi-symmetric tubes (one for fuel and one for oxidizer), which produce a flat, disk-like counter-flow diffusion flame. This paper presents results of experiments to measure extinction limits for n-heptane and the military specification fuel JP-7, obtained from an OJB. JP-7 is an Air Force-developed fuel that continues to be important in the area of hypersonics. Because of its distinct properties it is currently the hydrocarbon fuel of choice for use in Scramjet engines. This study provides much-desired data for JP-7, for which very little information previously existed. The interest in n-heptane is twofold. First, there has been a significant amount of previous extinction limit study and resulting data with this fuel. Second, n-heptane (C7H16) is a pure substance, and therefore does not vary in composition as does JP-7, which is a mixture of several different hydrocarbons. These two facts allow for a baseline to be established by comparing the new OJB results to those previously taken. Additionally, the data set for n-heptane, which previously existed for mixtures up to 26 mole percent in nitrogen, is completed up to 100% n-heptane. The extinction limit data for the two fuels are compared, and complete experimental results are included.
AGU Publications Continue to Rank High in 2012 Journal Citation Reports
NASA Astrophysics Data System (ADS)
Warner, Mary
2013-07-01
AGU journals continue to rank high in the 2012 Journal Citation Reports® (JCR), which was released by Thomson Reuters on 19 June. The impact factor of several AGU journals increased significantly, continuing their trend of the previous 5 years, while others remained consistent with the previous year's ranking.
Locatelli, Francesco; Choukroun, Gabriel; Truman, Matt; Wiggenhauser, Alfons; Fliser, Danilo
2016-04-01
Erythropoiesis-stimulating agents and iron are commonly used in patients with chronic kidney disease with the aim of correcting anemia and maintaining stable hemoglobin levels. We analyzed pooled data from 13 studies with similar designs included in the Umbrella Continuous Erythropoietin Receptor Activator (C.E.R.A.) program to investigate the effects of continuous erythropoiesis receptor activator in clinically relevant subgroups of patients with chronic kidney disease and to determine whether the efficacy and safety outcomes demonstrated in the overall chronic kidney disease population are maintained in specific subgroups. Data from 13 Phase III trials set up with similar design were retrospectively pooled for this analysis. Patients with chronic kidney disease who had previously been receiving epoetin or darbepoetin were switched to continuous erythropoiesis receptor activator once-monthly after a 4- to 8-week screening period. Patients entered a 16-week continuous erythropoiesis receptor activator dose-titration period followed by an 8-week evaluation period. In total, 2060 patients were included in the analysis. Subgroups were defined based on: hemoglobin target range [lower (10.0-12.0 g/dL)/upper (10.5-13.0 g/dL)], gender (female/male), age (<65/≥65), baseline N-terminal pro-B-type natriuretic peptide levels (<5000/≥5000), cardiovascular risk factors (diabetes/cardiac/vascular/none). Across all subgroups analyzed, switching from shorter-acting erythropoiesis-stimulating agents to continuous erythropoiesis receptor activator once-monthly maintained stable hemoglobin concentrations in a high proportion of patients (78%), with only moderate hemoglobin fluctuations and a low number of dose changes. The safety profile across subgroups was as expected based on pre-existing risk factors; observed increases in adverse events were attributable to underlying risk factors rather than study drug. This retrospective analysis of 13 trials showed that continuous erythropoiesis receptor activator once-monthly maintained stable hemoglobin levels across a number of clinically relevant patient subgroups, including those with higher inherent cardiovascular risk. The safety profile was consistent with that previously established in the chronic kidney disease population. CLINICALTRIALS. NCT00413894/NCT00545571/NCT00517413/NCT00560404/NCT00882713/NCT00550680/NCT00576303/NCT00660023/NCT00717821/NCT00642850/NCT00605293/NCT00661505/NCT00699348. F. Hoffmann-La Roche Ltd, Basel, Switzerland.
NASA Astrophysics Data System (ADS)
Xiang, Yu; Xu, Buqing; Mišta, Ladislav; Tufarelli, Tommaso; He, Qiongyi; Adesso, Gerardo
2017-10-01
Einstein-Podolsky-Rosen (EPR) steering is an asymmetric form of correlations which is intermediate between quantum entanglement and Bell nonlocality, and can be exploited as a resource for quantum communication with one untrusted party. In particular, steering of continuous-variable Gaussian states has been extensively studied theoretically and experimentally, as a fundamental manifestation of the EPR paradox. While most of these studies focused on quadrature measurements for steering detection, two recent works revealed that there exist Gaussian states which are only steerable by suitable non-Gaussian measurements. In this paper we perform a systematic investigation of EPR steering of bipartite Gaussian states by pseudospin measurements, complementing and extending previous findings. We first derive the density-matrix elements of two-mode squeezed thermal Gaussian states in the Fock basis, which may be of independent interest. We then use such a representation to investigate steering of these states as detected by a simple nonlinear criterion, based on second moments of the correlation matrix constructed from pseudospin operators. This analysis reveals previously unexplored regimes where non-Gaussian measurements are shown to be more effective than Gaussian ones to witness steering of Gaussian states in the presence of local noise. We further consider an alternative set of pseudospin observables, whose expectation value can be expressed more compactly in terms of Wigner functions for all two-mode Gaussian states. However, according to the adopted criterion, these observables are found to be always less sensitive than conventional Gaussian observables for steering detection. Finally, we investigate continuous-variable Werner states, which are non-Gaussian mixtures of Gaussian states, and find that pseudospin measurements are always more effective than Gaussian ones to reveal their steerability. Our results provide useful insights on the role of non-Gaussian measurements in characterizing quantum correlations of Gaussian and non-Gaussian states of continuous-variable quantum systems.
NASA Astrophysics Data System (ADS)
Zaragoza, S. A.; Snelson, C. M.; Jernsletten, J. A.; Saldana, S. C.; Hirsch, A.; McEwan, D.
2005-12-01
The Black Hills fault (BHF) is located in the central Basin and Range Province of western North America, a region that has undergone significant Cenozoic extension. The BHF is an east-dipping normal fault that forms the northwestern structural boundary of the Eldorado basin and lies ~20 km southeast of Las Vegas, Nevada. A recent trench study indicated that the fault offsets Holocene strata, and is capable of producing Mw 6.4-6.8 earthquakes. These estimates indicate a subsurface rupture length at least 10 km greater than the length of the scarp. This poses a significant hazard to structures such as the nearby Hoover Dam Bypass Bridge, which is being built to withstand a Mw 6.2-7.0 earthquake on local faults. If the BHF does continue in the subsurface, this structure, as well as nearby communities (Las Vegas, Boulder City, and Henderson), may not be as safe as previously expected. Previous attempts to image the fault with shallow seismics (hammer source) were inconclusive. However, gravity studies imply that the fault continues south of the scarp. Therefore, a new experiment utilizing high-resolution seismic reflection was performed to image subsurface geologic structures south of the scarp. At each shot point, a stack of four 30-160 Hz vibroseis sweeps of 15 s duration was recorded on a 60-channel system with 40 Hz geophones. This produced two 300 m reflection profiles, with a maximum depth of 500-600 m. A preliminary look at these data indicates the existence of two faults, potentially confirming that the BHF continues in the subsurface south of the scarp.
Advanced Laser Based Measurements in Porous Media Combustion
NASA Technical Reports Server (NTRS)
Tedder, Sarah A.
2009-01-01
We present measurements using dual-pump dual-broadband coherent anti-Stokes Raman scattering spectroscopy (DP-DBB-CARS) inside a porous media burner. This work continues our previous measurements in such combustion systems. The existing setup was significantly modified with the aim of providing improved data quality and data rate, reduction of interferences and additional species information. These changes are presented and discussed in detail. The CARS technique was expanded to a dual-pump dual-broadband CARS system which in principle enables acquisition of temperatures together with relative H2/N2- and O2/N2- species concentrations. Experimental complexity was reduced by the use of a modified spectrometer enabling the detection of both signals, vibrational and rotational CARS, with only one detection system.
Narayanan, Shrikanth; Toutios, Asterios; Ramanarayanan, Vikram; Lammert, Adam; Kim, Jangwon; Lee, Sungbok; Nayak, Krishna; Kim, Yoon-Chul; Zhu, Yinghua; Goldstein, Louis; Byrd, Dani; Bresch, Erik; Ghosh, Prasanta; Katsamanis, Athanasios; Proctor, Michael
2014-01-01
USC-TIMIT is an extensive database of multimodal speech production data, developed to complement existing resources available to the speech research community and with the intention of being continuously refined and augmented. The database currently includes real-time magnetic resonance imaging data from five male and five female speakers of American English. Electromagnetic articulography data have also been presently collected from four of these speakers. The two modalities were recorded in two independent sessions while the subjects produced the same 460 sentence corpus used previously in the MOCHA-TIMIT database. In both cases the audio signal was recorded and synchronized with the articulatory data. The database and companion software are freely available to the research community. PMID:25190403
Bakerly, Nawar Diar; Woodcock, Ashley; New, John P; Gibson, J Martin; Wu, Wei; Leather, David; Vestbo, Jørgen
2015-09-04
New treatments need to be evaluated in real-world clinical practice to account for co-morbidities, adherence and polypharmacy. Patients with chronic obstructive pulmonary disease (COPD), ≥ 40 years old, with exacerbation in the previous 3 years are randomised 1:1 to once-daily fluticasone furoate 100 μg/vilanterol 25 μg in a novel dry-powder inhaler versus continuing their existing therapy. The primary endpoint is the mean annual rate of COPD exacerbations; an electronic medical record allows real-time collection and monitoring of endpoint and safety data. The Salford Lung Study is the world's first pragmatic randomised controlled trial of a pre-licensed medication in COPD. Clinicaltrials.gov identifier NCT01551758.
Dorio, JoAnn
2004-01-01
Job initiation rates are steadily improving for people with severe and persistent mental illnesses. Yet, job retention rates, especially for those individuals who historically have had difficulty maintaining employment, continue to concern vocational rehabilitation professionals. In this paper, the author develops and refines her ideas that were presented in a previous research paper titled "Differences in Job Retention in a Supported Employment Program, Chinook Clubhouse." A more complete model, "The PASS to Success," is suggested by incorporating existing research with the author's revised work. Components of the model (Placement, Attitude, Support, Skills), can be used to predict vocational success and promote job retention.
NASA and ESA Collaboration on Hexavalent Chrome Alternatives Pretreatments Only Interim Test Report
NASA Technical Reports Server (NTRS)
Kessel, Kurt R.
2015-01-01
NASA and ESA continue to search for an alternative to hexavalent chromium in coatings applications that meet their performance requirements in corrosion protection, cost, operability, and health and safety, while typically specifying that performance must be equal to or greater than existing systems. The overall objective of the collaborative effort between NASA TEERM and ESA is to test and evaluate coating systems (pretreatments, pretreatments with primer, and pretreatments with primer and topcoat) as replacements for hexavalent chrome coatings in aerospace applications. This objective will be accomplished by testing promising coatings identified from previous NASA, ESA, Department of Defense (DOD), and other project experience. Additionally, several new materials will be analyzed according to ESA-identified specifications.
Is risky sexual behavior continuous or categorical? A taxometric analysis of the Sexual Risk Survey.
Marcus, David K; Fulton, Jessica J; Turchik, Jessica A
2011-03-01
Risky sexual behaviors are behaviors that involve the possibility of an adverse outcome, such as contracting a sexually transmitted infection or unwanted pregnancy. The question of whether risky sexual behavior exists as a discrete class (i.e., taxon) or as a dimensional construct has not previously been explored. The authors performed a set of taxometric analyses on 4 factor scales derived from the Sexual Risk Survey (Turchik & Garske, 2009) with data from 1,103 college students. The results provided consistent support for a dimensional latent structure in which variations in reported risky sexual behavior reflect differences in degree and not differences in kind. The implications of these findings for the assessment of risky sexual behavior are discussed.
Sovány, Tamás; Papós, Kitti; Kása, Péter; Ilič, Ilija; Srčič, Stane; Pintye-Hódi, Klára
2013-06-01
The importance of in silico modeling in the pharmaceutical industry is continuously increasing. The aim of the present study was the development of a neural network model for prediction of the postcompressional properties of scored tablets based on the application of existing data sets from our previous studies. Some important process parameters and physicochemical characteristics of the powder mixtures were used as training factors to achieve the best applicability in a wide range of possible compositions. The results demonstrated that, after some pre-processing of the factors, an appropriate prediction performance could be achieved. However, because of the poor extrapolation capacity, broadening of the training data range appears necessary.
The Use of a Block Diagram Simulation Language for Rapid Model Prototyping
NASA Technical Reports Server (NTRS)
Whitlow, Johnathan E.; Engrand, Peter
1996-01-01
The research performed this summer was a continuation of work performed during the 1995 NASA/ASEE Summer Fellowship. The focus of the work was to expand previously generated predictive models for liquid oxygen (LOX) loading into the external fuel tank of the shuttle. The models which were developed using a block diagram simulation language known as VisSim, were evaluated on numerous shuttle flights and found to well in most cases. Once the models were refined and validated, the predictive methods were integrated into the existing Rockwell software propulsion advisory tool (PAT). Although time was not sufficient to completely integrate the models developed into PAT, the ability to predict flows and pressures in the orbiter section and graphically display the results was accomplished.
Study of interhemispheric asymmetries in electroencephalographic signals by frequency analysis
NASA Astrophysics Data System (ADS)
Zapata, J. F.; Garzón, J.
2011-01-01
This study provides a new method for the detection of interhemispheric asymmetries in patients with continuous video-electroencephalography (EEG) monitoring at Intensive Care Unit (ICU), using wavelet energy. We obtained the registration of EEG signals in 42 patients with different pathologies, and then we proceeded to perform signal processing using the Matlab program, we compared the abnormalities recorded in the report by the neurophysiologist, the images of each patient and the result of signals analysis with the Discrete Wavelet Transform (DWT). Conclusions: there exists correspondence between the abnormalities found in the processing of the signal with the clinical reports of findings in patients; according to previous conclusion, the methodology used can be a useful tool for diagnosis and early quantitative detection of interhemispheric asymmetries.
North Antelope Highlands Wind Project
DOE Office of Scientific and Technical Information (OSTI.GOV)
Pearlson, Matthew
This is the final report on the Wind Energy Development of 190 Mw on the Rosebud Indian Reservation in collaboration with Citizens Energy Corporation. The report discusses all pre-development activities since July of 2010 when award was granted. A systems impact study along with wind data accumulated over the past 5 years is contained in this report. We have responded to several RFPs concerning the sale of energy to certain offtakers, but we have failed to win a Power Purchase Agreement due to existing wind farms that won and the interconnection costs were already included in a previous PPAs, whichmore » we don't have that luxury. We continue this effort and hopefully in the near future we will win an RFP.« less
Three-dimensional structure of the submarine flanks of La Réunion inferred from geophysical data
NASA Astrophysics Data System (ADS)
Gailler, Lydie-Sarah; LéNat, Jean-FrançOis
2010-12-01
La Réunion (Indian Ocean) constitutes a huge volcanic oceanic system of which most of the volume is submerged. We present a study of its submarine part based on the interpretation of magnetic and gravity data compiled from old and recent surveys. A model of the submarine internal structure is derived from 3-D and 2-D models using constraints from previous geological and geophysical studies. Two large-scale, previously unknown, buried volcanic construction zones are discovered in continuation of the island's construction. To the east, the Alizés submarine zone is interpreted as the remnants of Les Alizés volcano eastward flank whose center is marked by a large hypovolcanic intrusion complex. To the southwest, the Etang Salé submarine zone is interpreted as an extension of Piton des Neiges, probably fed by a volcanic rift zone over a large extent. They were predominantly built during the Matuyama period and thus probably belong to early volcanism. A correlation exists between their top and seismic horizons recognized in previous studies and interpreted as the base of the volcanic edifice. Their morphology suggested a lithospheric bulging beneath La Réunion, not required to explain our data, since the seismic interfaces match the top of our volcanic constructions. The coastal shelf coincides with a negative Bouguer anomaly belt, often associated with magnetic anomalies, suggesting a shelf built by hyaloclastites. A detailed analysis of the offshore continuation of La Montagne Massif to the north confirms this hypothesis. The gravity analysis confirms that the bathymetric bulges, forming the northern, eastern, southern, and western submarine flanks, are predominantly built by debris avalanche deposits at the surface.
Haga, Ken; Sakai, Tatsuya
2012-10-01
Auxin efflux carrier PIN-FORMED (PIN) proteins are thought to have central roles in regulating asymmetrical auxin translocation during tropic responses, including gravitropism and phototropism, in plants. Although PIN3 is known to be involved in phototropism in Arabidopsis (Arabidopsis thaliana), no severe defects of phototropism in any of the pin mutants have been reported. We show here that the pulse-induced, first positive phototropism is impaired partially in pin1, pin3, and pin7 single mutants, and severely in triple mutants. In contrast, such impairment was not observed in continuous-light-induced second positive phototropism. Analysis with an auxin-reporter gene demonstrated that PIN3-mediated auxin gradients participate in pulse-induced phototropism but not in continuous-light-induced phototropism. Similar functional separation was also applicable to PINOID, a regulator of PIN localization. Our results strongly suggest the existence of functionally distinct mechanisms i.e. a PIN-dependent mechanism in which transient stimulation is sufficient to induce phototropism, and a PIN-independent mechanism that requires continuous stimulation and does not operate in the former phototropism process. Although a previous study has proposed that blue-light photoreceptors, the phototropins, control PIN localization through the transcriptional down-regulation of PINOID, we could not detect this blue-light-dependent down-regulation event, suggesting that other as yet unknown mechanisms are involved in phototropin-mediated phototropic responses.
Haga, Ken; Sakai, Tatsuya
2012-01-01
Auxin efflux carrier PIN-FORMED (PIN) proteins are thought to have central roles in regulating asymmetrical auxin translocation during tropic responses, including gravitropism and phototropism, in plants. Although PIN3 is known to be involved in phototropism in Arabidopsis (Arabidopsis thaliana), no severe defects of phototropism in any of the pin mutants have been reported. We show here that the pulse-induced, first positive phototropism is impaired partially in pin1, pin3, and pin7 single mutants, and severely in triple mutants. In contrast, such impairment was not observed in continuous-light-induced second positive phototropism. Analysis with an auxin-reporter gene demonstrated that PIN3-mediated auxin gradients participate in pulse-induced phototropism but not in continuous-light-induced phototropism. Similar functional separation was also applicable to PINOID, a regulator of PIN localization. Our results strongly suggest the existence of functionally distinct mechanisms i.e. a PIN-dependent mechanism in which transient stimulation is sufficient to induce phototropism, and a PIN-independent mechanism that requires continuous stimulation and does not operate in the former phototropism process. Although a previous study has proposed that blue-light photoreceptors, the phototropins, control PIN localization through the transcriptional down-regulation of PINOID, we could not detect this blue-light-dependent down-regulation event, suggesting that other as yet unknown mechanisms are involved in phototropin-mediated phototropic responses. PMID:22843667
Weiss, Scott T.
2014-01-01
Bayesian Networks (BN) have been a popular predictive modeling formalism in bioinformatics, but their application in modern genomics has been slowed by an inability to cleanly handle domains with mixed discrete and continuous variables. Existing free BN software packages either discretize continuous variables, which can lead to information loss, or do not include inference routines, which makes prediction with the BN impossible. We present CGBayesNets, a BN package focused around prediction of a clinical phenotype from mixed discrete and continuous variables, which fills these gaps. CGBayesNets implements Bayesian likelihood and inference algorithms for the conditional Gaussian Bayesian network (CGBNs) formalism, one appropriate for predicting an outcome of interest from, e.g., multimodal genomic data. We provide four different network learning algorithms, each making a different tradeoff between computational cost and network likelihood. CGBayesNets provides a full suite of functions for model exploration and verification, including cross validation, bootstrapping, and AUC manipulation. We highlight several results obtained previously with CGBayesNets, including predictive models of wood properties from tree genomics, leukemia subtype classification from mixed genomic data, and robust prediction of intensive care unit mortality outcomes from metabolomic profiles. We also provide detailed example analysis on public metabolomic and gene expression datasets. CGBayesNets is implemented in MATLAB and available as MATLAB source code, under an Open Source license and anonymous download at http://www.cgbayesnets.com. PMID:24922310
McGeachie, Michael J; Chang, Hsun-Hsien; Weiss, Scott T
2014-06-01
Bayesian Networks (BN) have been a popular predictive modeling formalism in bioinformatics, but their application in modern genomics has been slowed by an inability to cleanly handle domains with mixed discrete and continuous variables. Existing free BN software packages either discretize continuous variables, which can lead to information loss, or do not include inference routines, which makes prediction with the BN impossible. We present CGBayesNets, a BN package focused around prediction of a clinical phenotype from mixed discrete and continuous variables, which fills these gaps. CGBayesNets implements Bayesian likelihood and inference algorithms for the conditional Gaussian Bayesian network (CGBNs) formalism, one appropriate for predicting an outcome of interest from, e.g., multimodal genomic data. We provide four different network learning algorithms, each making a different tradeoff between computational cost and network likelihood. CGBayesNets provides a full suite of functions for model exploration and verification, including cross validation, bootstrapping, and AUC manipulation. We highlight several results obtained previously with CGBayesNets, including predictive models of wood properties from tree genomics, leukemia subtype classification from mixed genomic data, and robust prediction of intensive care unit mortality outcomes from metabolomic profiles. We also provide detailed example analysis on public metabolomic and gene expression datasets. CGBayesNets is implemented in MATLAB and available as MATLAB source code, under an Open Source license and anonymous download at http://www.cgbayesnets.com.
NASA Astrophysics Data System (ADS)
Fagereng, A.; Hodge, M.; Biggs, J.; Mdala, H. S.; Goda, K.
2016-12-01
Faults grow through the interaction and linkage of isolated fault segments. Continuous fault systems are those where segments interact, link and may slip synchronously, whereas non-continuous fault systems comprise isolated faults. As seismic moment is related to fault length (Wells and Coppersmith, 1994), understanding whether a fault system is continuous or not is critical in evaluating seismic hazard. Maturity may be a control on fault continuity: immature, low displacement faults are typically assumed to be non-continuous. Here, we study two overlapping, 20 km long, normal fault segments of the N-S striking Bilila-Mtakataka fault, Malawi, in the southern section of the East African Rift System. Despite its relative immaturity, previous studies concluded the Bilila-Mtakataka fault is continuous for its entire 100 km length, with the most recent event equating to an Mw8.0 earthquake (Jackson and Blenkinsop, 1997). We explore whether segment geometry and relationship to pre-existing high-grade metamorphic foliation has influenced segment interaction and fault development. Fault geometry and scarp height is constrained by DEMs derived from SRTM, Pleiades and `Structure from Motion' photogrammetry using a UAV, alongside direct field observations. The segment strikes differ on average by 10°, but up to 55° at their adjacent tips. The southern segment is sub-parallel to the foliation, whereas the northern segment is highly oblique to the foliation. Geometrical surface discontinuities suggest two isolated faults; however, displacement-length profiles and Coulomb stress change models suggest segment interaction, with potential for linkage at depth. Further work must be undertaken on other segments to assess the continuity of the entire fault, concluding whether an earthquake greater than that of the maximum instrumentally recorded (1910 M7.4 Rukwa) is possible.
Lyapounov Functions of Closed Cone Fields: From Conley Theory to Time Functions
NASA Astrophysics Data System (ADS)
Bernard, Patrick; Suhr, Stefan
2018-03-01
We propose a theory "à la Conley" for cone fields using a notion of relaxed orbits based on cone enlargements, in the spirit of space time geometry. We work in the setting of closed (or equivalently semi-continuous) cone fields with singularities. This setting contains (for questions which are parametrization independent such as the existence of Lyapounov functions) the case of continuous vector-fields on manifolds, of differential inclusions, of Lorentzian metrics, and of continuous cone fields. We generalize to this setting the equivalence between stable causality and the existence of temporal functions. We also generalize the equivalence between global hyperbolicity and the existence of a steep temporal function.
The 22 March 2014 Oso landslide, Washington, USA
NASA Astrophysics Data System (ADS)
Wartman, Joseph; Montgomery, David R.; Anderson, Scott A.; Keaton, Jeffrey R.; Benoît, Jean; dela Chapelle, John; Gilbert, Robert
2016-01-01
The Oso, Washington, USA, landslide occurred on the morning of Saturday, 22 March 2014 and claimed the lives of 43 people. The landslide began within an 200-m-high hillslope comprised of unconsolidated glacial and previous landslide/colluvial deposits; it continued as a debris avalanche/debris flow that rapidly inundated a neighborhood of 35 single-family residences. An intense three-week rainfall that immediately preceded the event most likely played a role in triggering the landslide; and other factors that likely contributed to destabilization of the landslide mass include alteration of the local groundwater recharge and hydrogeological regime from previous landsliding, weakening and alteration of the landslide mass caused by previous landsliding, and changes in stress distribution resulting from removal and deposition of material from earlier landsliding. Field reconnaissance following the event revealed six distinctive zones and several subzones that are characterized on the basis of geomorphic expression, styles of deformation, geologic materials, and the types, size, and orientation of vegetation. Seismic recording of the landslide indicate that the event was marked by several vibration-generating episodes of mass movement. We hypothesize that the landslide occurred in two stages, with the first being a sequential remobilization of existing slide masses from the most recent (2006) landslide and from an ancient slide that triggered a devastating debris avalanche/debris flow. The second stage involved headward extension into previously unfailed material that occurred in response to unloading and redirection of stresses.
What Comes after Stable Octet? Stable Sub-Shell!
ERIC Educational Resources Information Center
Tan, Kim Chwee Daniel; Taber, Keith S.
2005-01-01
Previous research has shown that students' existing conceptions are critical to subsequent learning because there is interaction between the new knowledge that the students encounter and their existing knowledge from previous lessons. Taber (1999a) found A-level students in the UK had difficulty in understanding the principles determining the…
40 CFR 429.145 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2010 CFR
2010-07-01
... (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS TIMBER PRODUCTS PROCESSING POINT SOURCE CATEGORY Particleboard Manufacturing Subcategory § 429.145 Pretreatment standards for existing sources (PSES). Any existing source...
Federal Register 2010, 2011, 2012, 2013, 2014
2013-05-15
... enable the TPH to meet its existing obligations to customers. In addition, such procedures must address the TPH's existing relationships with other broker-dealers and third parties. The business continuity... business continuity plan if such TPH has public customers. If the TPH does not have public customers, the...
How Small School Districts Can Organize to Afford Their Small Schools
ERIC Educational Resources Information Center
Burton, Christine
2010-01-01
While the research continues to mount on the benefits of school downsizing and decentralizing efforts in urban areas, there exists a paradox for small school Administrators who continue to struggle against forces of consolidation. Small schools in rural and suburban districts have fought for their existence against the pressures of consolidation…
40 CFR 147.753 - Existing Class I and III wells authorized by rule.
Code of Federal Regulations, 2010 CFR
2010-07-01
... (CONTINUED) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Indiana § 147.753 Existing Class I and III wells authorized by rule. Maximum injection pressure. The owner or operator shall limit injection pressure to the lessor of: (a) A value which will not...
Optimal control of anthracnose using mixed strategies.
Fotsa Mbogne, David Jaures; Thron, Christopher
2015-11-01
In this paper we propose and study a spatial diffusion model for the control of anthracnose disease in a bounded domain. The model is a generalization of the one previously developed in [15]. We use the model to simulate two different types of control strategies against anthracnose disease. Strategies that employ chemical fungicides are modeled using a continuous control function; while strategies that rely on cultivational practices (such as pruning and removal of mummified fruits) are modeled with a control function which is discrete in time (though not in space). For comparative purposes, we perform our analyses for a spatially-averaged model as well as the space-dependent diffusion model. Under weak smoothness conditions on parameters we demonstrate the well-posedness of both models by verifying existence and uniqueness of the solution for the growth inhibition rate for given initial conditions. We also show that the set [0, 1] is positively invariant. We first study control by impulsive strategies, then analyze the simultaneous use of mixed continuous and pulse strategies. In each case we specify a cost functional to be minimized, and we demonstrate the existence of optimal control strategies. In the case of pulse-only strategies, we provide explicit algorithms for finding the optimal control strategies for both the spatially-averaged model and the space-dependent model. We verify the algorithms for both models via simulation, and discuss properties of the optimal solutions. Copyright © 2015 Elsevier Inc. All rights reserved.
A qualitative study of user perceptions of mobile health apps.
Peng, Wei; Kanthawala, Shaheen; Yuan, Shupei; Hussain, Syed Ali
2016-11-14
Mobile apps for health exist in large numbers today, but oftentimes, consumers do not continue to use them after a brief period of initial usage, are averse toward using them at all, or are unaware that such apps even exist. The purpose of our study was to examine and qualitatively determine the design and content elements of health apps that facilitate or impede usage from the users' perceptive. In 2014, six focus groups and five individual interviews were conducted in the Midwest region of the U.S. with a mixture of 44 smartphone owners of various social economic status. The participants were asked about their general and health specific mobile app usage. They were then shown specific features of exemplar health apps and prompted to discuss their perceptions. The focus groups and interviews were audio recorded, transcribed verbatim, and coded using the software NVivo. Inductive thematic analysis was adopted to analyze the data and nine themes were identified: 1) barriers to adoption of health apps, 2) barriers to continued use of health apps, 3) motivators, 4) information and personalized guidance, 5) tracking for awareness and progress, 6) credibility, 7) goal setting, 8) reminders, and 9) sharing personal information. The themes were mapped to theories for interpretation of the results. This qualitative research with a diverse pool of participants extended previous research on challenges and opportunities of health apps. The findings provide researchers, app designers, and health care providers insights on how to develop and evaluate health apps from the users' perspective.
Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update.
Sarin, S K; Kumar, M; Lau, G K; Abbas, Z; Chan, H L Y; Chen, C J; Chen, D S; Chen, H L; Chen, P J; Chien, R N; Dokmeci, A K; Gane, Ed; Hou, J L; Jafri, W; Jia, J; Kim, J H; Lai, C L; Lee, H C; Lim, S G; Liu, C J; Locarnini, S; Al Mahtab, M; Mohamed, R; Omata, M; Park, J; Piratvisuth, T; Sharma, B C; Sollano, J; Wang, F S; Wei, L; Yuen, M F; Zheng, S S; Kao, J H
2016-01-01
Worldwide, some 240 million people have chronic hepatitis B virus (HBV), with the highest rates of infection in Africa and Asia. Our understanding of the natural history of HBV infection and the potential for therapy of the resultant disease is continuously improving. New data have become available since the previous APASL guidelines for management of HBV infection were published in 2012. The objective of this manuscript is to update the recommendations for the optimal management of chronic HBV infection. The 2015 guidelines were developed by a panel of Asian experts chosen by the APASL. The clinical practice guidelines are based on evidence from existing publications or, if evidence was unavailable, on the experts' personal experience and opinion after deliberations. Manuscripts and abstracts of important meetings published through January 2015 have been evaluated. This guideline covers the full spectrum of care of patients infected with hepatitis B, including new terminology, natural history, screening, vaccination, counseling, diagnosis, assessment of the stage of liver disease, the indications, timing, choice and duration of single or combination of antiviral drugs, screening for HCC, management in special situations like childhood, pregnancy, coinfections, renal impairment and pre- and post-liver transplant, and policy guidelines. However, areas of uncertainty still exist, and clinicians, patients, and public health authorities must therefore continue to make choices on the basis of the evolving evidence. The final clinical practice guidelines and recommendations are presented here, along with the relevant background information.
A pneumatic Bionic Voice prosthesis-Pre-clinical trials of controlling the voice onset and offset.
Ahmadi, Farzaneh; Noorian, Farzad; Novakovic, Daniel; van Schaik, André
2018-01-01
Despite emergent progress in many fields of bionics, a functional Bionic Voice prosthesis for laryngectomy patients (larynx amputees) has not yet been achieved, leading to a lifetime of vocal disability for these patients. This study introduces a novel framework of Pneumatic Bionic Voice Prostheses as an electronic adaptation of the Pneumatic Artificial Larynx (PAL) device. The PAL is a non-invasive mechanical voice source, driven exclusively by respiration with an exceptionally high voice quality, comparable to the existing gold standard of Tracheoesophageal (TE) voice prosthesis. Following PAL design closely as the reference, Pneumatic Bionic Voice Prostheses seem to have a strong potential to substitute the existing gold standard by generating a similar voice quality while remaining non-invasive and non-surgical. This paper designs the first Pneumatic Bionic Voice prosthesis and evaluates its onset and offset control against the PAL device through pre-clinical trials on one laryngectomy patient. The evaluation on a database of more than five hours of continuous/isolated speech recordings shows a close match between the onset/offset control of the Pneumatic Bionic Voice and the PAL with an accuracy of 98.45 ±0.54%. When implemented in real-time, the Pneumatic Bionic Voice prosthesis controller has an average onset/offset delay of 10 milliseconds compared to the PAL. Hence it addresses a major disadvantage of previous electronic voice prostheses, including myoelectric Bionic Voice, in meeting the short time-frames of controlling the onset/offset of the voice in continuous speech.
A pneumatic Bionic Voice prosthesis—Pre-clinical trials of controlling the voice onset and offset
Noorian, Farzad; Novakovic, Daniel; van Schaik, André
2018-01-01
Despite emergent progress in many fields of bionics, a functional Bionic Voice prosthesis for laryngectomy patients (larynx amputees) has not yet been achieved, leading to a lifetime of vocal disability for these patients. This study introduces a novel framework of Pneumatic Bionic Voice Prostheses as an electronic adaptation of the Pneumatic Artificial Larynx (PAL) device. The PAL is a non-invasive mechanical voice source, driven exclusively by respiration with an exceptionally high voice quality, comparable to the existing gold standard of Tracheoesophageal (TE) voice prosthesis. Following PAL design closely as the reference, Pneumatic Bionic Voice Prostheses seem to have a strong potential to substitute the existing gold standard by generating a similar voice quality while remaining non-invasive and non-surgical. This paper designs the first Pneumatic Bionic Voice prosthesis and evaluates its onset and offset control against the PAL device through pre-clinical trials on one laryngectomy patient. The evaluation on a database of more than five hours of continuous/isolated speech recordings shows a close match between the onset/offset control of the Pneumatic Bionic Voice and the PAL with an accuracy of 98.45 ±0.54%. When implemented in real-time, the Pneumatic Bionic Voice prosthesis controller has an average onset/offset delay of 10 milliseconds compared to the PAL. Hence it addresses a major disadvantage of previous electronic voice prostheses, including myoelectric Bionic Voice, in meeting the short time-frames of controlling the onset/offset of the voice in continuous speech. PMID:29466455
NASA Astrophysics Data System (ADS)
Edwards, Matthew; Guggilla, Padmaja; Reedy, Angela; Ijaz, Quratulann; Janen, Afef; Uba, Samuel; Curley, Michael
2017-08-01
Previously, we have reported measurements of temperature-dependent surface resistivity of pure and multi-walled carbon nanotube (MWNCT) doped amorphous Polyvinyl Alcohol (PVA) thin films. In the temperature range from 22 °C to 40 °C with humidity-controlled environment, we found the surface resistivity to decrease initially, but to rise steadily as the temperature continued to increase. Moreover, electric surface current density (Js) was measured on the surface of pure and MWCNT doped PVA thin films. In this regard, the surface current density and electric field relationship follow Ohm's law at low electric fields. Unlike Ohmic conduction in metals where free electrons exist, selected captive electrons are freed or provided from impurities and dopants to become conduction electrons from increased thermal vibration of constituent atoms in amorphous thin films. Additionally, a mechanism exists that seemingly decreases the surface resistivity at higher temperatures, suggesting a blocking effect for conducting electrons. Volume resistivity measurements also follow Ohm's law at low voltages (low electric fields), and they continue to decrease as temperatures increase in this temperature range, differing from surface resistivity behavior. Moreover, we report measurements of dielectric constant and dielectric loss as a function of temperature and frequency. Both the dielectric constant and dielectric loss were observed to be highest for MWCNT doped PVA compared to pure PVA and commercial paper, and with frequency and temperature for all samples.
Surface-from-gradients without discrete integrability enforcement: A Gaussian kernel approach.
Ng, Heung-Sun; Wu, Tai-Pang; Tang, Chi-Keung
2010-11-01
Representative surface reconstruction algorithms taking a gradient field as input enforce the integrability constraint in a discrete manner. While enforcing integrability allows the subsequent integration to produce surface heights, existing algorithms have one or more of the following disadvantages: They can only handle dense per-pixel gradient fields, smooth out sharp features in a partially integrable field, or produce severe surface distortion in the results. In this paper, we present a method which does not enforce discrete integrability and reconstructs a 3D continuous surface from a gradient or a height field, or a combination of both, which can be dense or sparse. The key to our approach is the use of kernel basis functions, which transfer the continuous surface reconstruction problem into high-dimensional space, where a closed-form solution exists. By using the Gaussian kernel, we can derive a straightforward implementation which is able to produce results better than traditional techniques. In general, an important advantage of our kernel-based method is that the method does not suffer discretization and finite approximation, both of which lead to surface distortion, which is typical of Fourier or wavelet bases widely adopted by previous representative approaches. We perform comparisons with classical and recent methods on benchmark as well as challenging data sets to demonstrate that our method produces accurate surface reconstruction that preserves salient and sharp features. The source code and executable of the system are available for downloading.
Book review: The Wilderness Debate Rages On: Continuing the Great New Wilderness Debate
Peter Landres
2009-01-01
The Wilderness Debate Rages On is a collection of mostly previously published papers about the meaning, value, and role of wilderness and continues the discussion that was propelled by the editors' previous book The Great New Wilderness Debate (also a collection of papers) published in 1998. The editors state that this sequel to their previous book is mandated...
Computing the Evans function via solving a linear boundary value ODE
NASA Astrophysics Data System (ADS)
Wahl, Colin; Nguyen, Rose; Ventura, Nathaniel; Barker, Blake; Sandstede, Bjorn
2015-11-01
Determining the stability of traveling wave solutions to partial differential equations can oftentimes be computationally intensive but of great importance to understanding the effects of perturbations on the physical systems (chemical reactions, hydrodynamics, etc.) they model. For waves in one spatial dimension, one may linearize around the wave and form an Evans function - an analytic Wronskian-like function which has zeros that correspond in multiplicity to the eigenvalues of the linearized system. If eigenvalues with a positive real part do not exist, the traveling wave will be stable. Two methods exist for calculating the Evans function numerically: the exterior-product method and the method of continuous orthogonalization. The first is numerically expensive, and the second reformulates the originally linear system as a nonlinear system. We develop a new algorithm for computing the Evans function through appropriate linear boundary-value problems. This algorithm is cheaper than the previous methods, and we prove that it preserves analyticity of the Evans function. We also provide error estimates and implement it on some classical one- and two-dimensional systems, one being the Swift-Hohenberg equation in a channel, to show the advantages.
Michael Young, the Institute of Community Studies, and the Politics of Kinship.
Butler, Lise
2015-01-01
This article examines the East London-based Institute of Community Studies, and its founder, Michael Young, to show that sociology and social research offered avenues for left-wing political expression in the 1950s. Young, who had previously been Head of the Labour Party Research Department during the Attlee government, drew upon existing currents of psychological and sociological research to emphasize the continuing relevance of the extended family in industrial society and to offer a model of socialist citizenship, solidarity and mutual support not tied to productive work. Young and his colleagues at the Institute of Community Studies promoted the supportive kinship networks of the urban working class, and an idealized conception of the relationships between women, to suggest that family had been overlooked by the left and should be reclaimed as a progressive force. The article shows that the Institute's sociological work was informed by a pre-existing concern with family as a model for cooperative socialism, and suggests that sociology and social research should be seen as important sources of political commentary for scholars of post-war politics.
The minicell TMirradiator: A new system for a new market
NASA Astrophysics Data System (ADS)
Clouser, James F.; Beers, Eric W.
1998-06-01
Since the commissioning of the first industrial Gamma Irradiator design, designers and operators of irradiation systems have been attempting to meet the specific production requirements and challenges presented to them. This objective has resulted in many different versions of irradiators currently in service today, all of which had original charters and many of which still perform very well within even the new requirements of this industry. Continuing changes in the marketplace have, however, placed pressures on existing designs due to a combination of changing dose requirements for sterlization, increased economic pressures from the specific industry served for both time and location and the increasing variety of product types requiring processing. Additionally, certain market areas which could never economically support a typical gamma processing facility have either not been serviced, or have forced potential gamma users to transport product long distances to one of these existing facilities. The MiniCell TM removes many of the traditional barriers previously accepted in the radiation processing industry for building a processing facility in a location. Its reduced size and cost have allowed many potential users to consider in-house processing and its ability to be quickly assembled allow it to meet market needs in a much more timely fashion than the previous designs. The MiniCell system can cost effectively meet many of the current market needs of reducing total cost of processing and also be flexible enough to process product in a wide range of industries effectively.
40 CFR Table 5 to Subpart G of... - Group 1 Storage Vessels at Existing Sources
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 9 2011-07-01 2011-07-01 false Group 1 Storage Vessels at Existing Sources 5 Table 5 to Subpart G of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES National Emission Standards for...
40 CFR Table 5 to Subpart G of... - Group 1 Storage Vessels at Existing Sources
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 9 2010-07-01 2010-07-01 false Group 1 Storage Vessels at Existing Sources 5 Table 5 to Subpart G of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES National Emission Standards for...
NASA Astrophysics Data System (ADS)
Sato, Kenji; Yano, Makoto
2012-09-01
Unique existence of the absolutely continuous ergodic measure, or existence of ergodic chaos (in a strong sense), has been considered important in economics since it explains the mechanism underlying economic fluctuations. In the present study, a simple sufficient condition for ergodic chaos is proved and applied to economic models.
40 CFR Table 5 to Subpart G of... - Group 1 Storage Vessels at Existing Sources
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 10 2014-07-01 2014-07-01 false Group 1 Storage Vessels at Existing Sources 5 Table 5 to Subpart G of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES National Emission Standards for...
40 CFR Table 5 to Subpart G of... - Group 1 Storage Vessels at Existing Sources
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 10 2013-07-01 2013-07-01 false Group 1 Storage Vessels at Existing Sources 5 Table 5 to Subpart G of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES National Emission Standards for...
40 CFR Table 5 to Subpart G of... - Group 1 Storage Vessels at Existing Sources
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 10 2012-07-01 2012-07-01 false Group 1 Storage Vessels at Existing Sources 5 Table 5 to Subpart G of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES National Emission Standards for...
Continuous Cover Forestry in the United States--Experience With Southern Pines
James M. Guldin
2002-01-01
Continuous cover forestry (CCF) has not been common in the southern United States, but if does exist. The best record of reseurch and practice exists for mixed loblolly-shortleaf pine (Pinus taeda L.-P. echinata Mill.) stands in the Upper West Gulf Coastal Plain west of the Mississippi River. After 60 years, the Good and Poor...
Cacchione, Trix
2013-09-01
One of the most fundamental achievements in infants' cognitive development is their appreciation that material objects exist permanently in space and time. Recent findings suggest that infants fail to identify fragmented material objects as continuously existing items. Four experiments assessed 8-12-month-old infants' ability to further represent an object that was fragmented into two or more parts. Results suggest that infants successfully trace the spatiotemporal displacement of fragmented objects, but that their processing of size/quantity-related property information may be affected. This suggests that, contrary to recent claims, 8- to 12-month-old infants can and do appreciate the continuity of fragmented objects. Copyright © 2013 Elsevier B.V. All rights reserved.
Three-Dimensional Piecewise-Continuous Class-Shape Transformation of Wings
NASA Technical Reports Server (NTRS)
Olson, Erik D.
2015-01-01
Class-Shape Transformation (CST) is a popular method for creating analytical representations of the surface coordinates of various components of aerospace vehicles. A wide variety of two- and three-dimensional shapes can be represented analytically using only a modest number of parameters, and the surface representation is smooth and continuous to as fine a degree as desired. This paper expands upon the original two-dimensional representation of airfoils to develop a generalized three-dimensional CST parametrization scheme that is suitable for a wider range of aircraft wings than previous formulations, including wings with significant non-planar shapes such as blended winglets and box wings. The method uses individual functions for the spanwise variation of airfoil shape, chord, thickness, twist, and reference axis coordinates to build up the complete wing shape. An alternative formulation parameterizes the slopes of the reference axis coordinates in order to relate the spanwise variation to the tangents of the sweep and dihedral angles. Also discussed are methods for fitting existing wing surface coordinates, including the use of piecewise equations to handle discontinuities, and mathematical formulations of geometric continuity constraints. A subsonic transport wing model is used as an example problem to illustrate the application of the methodology and to quantify the effects of piecewise representation and curvature constraints.
NASA Astrophysics Data System (ADS)
Rohling, E. J.
2014-12-01
Ice volume (and hence sea level) and deep-sea temperature are key measures of global climate change. Sea level has been documented using several independent methods over the past 0.5 million years (Myr). Older periods, however, lack such independent validation; all existing records are related to deep-sea oxygen isotope (d18O) data that are influenced by processes unrelated to sea level. For deep-sea temperature, only one continuous high-resolution (Mg/Ca-based) record exists, with related sea-level estimates, spanning the past 1.5 Myr. We have recently presented a novel sea-level reconstruction, with associated estimates of deep-sea temperature, which independently validates the previous 0-1.5 Myr reconstruction and extends it back to 5.3 Myr ago. A serious of caveats applies to this new method, especially in older times of its application, as is always the case with new methods. Independent validation exercises are needed to elucidate where consistency exists, and where solutions drift away from each other. A key observation from our new method is that a large temporal offset existed during the onset of Plio-Pleistocene ice ages, between a marked cooling step at 2.73 Myr ago and the first major glaciation at 2.15 Myr ago. This observation relies on relative changes within the dataset, which are more robust than absolute values. I will discuss our method and its main caveats and avenues for improvement.
White-Dzuro, Gabrielle A; Maynard, Ken; Zuckerman, Scott L; Weaver, Kyle D; Russell, Paul T; Clavenna, Matthew J; Chambless, Lola B
2016-07-01
Patients undergoing transsphenoidal surgery (TSS) have an anterior skull base defect that limits the use of positive pressure ventilation post-operatively. Obstructive sleep apnea (OSA) can be seen in these patients and is treated with continuous positive airway pressure (CPAP). In our study we documented the incidence of pre-existing OSA and reported the incidence of diagnosed pneumocephalus and its relationship to OSA. A retrospective review was conducted from a surgical outcomes database. Electronic medical records were reviewed, with an emphasis on diagnosis of OSA and documented symptomatic pneumocephalus. A total of 324 patients underwent 349 TSS for sellar mass resection. The average body mass index of the study cohort was 32.5kg/m(2). Sixty-nine patients (21%) had documented OSA. Only 25 out of 69 (36%) had a documented post-operative CPAP plan. Out of all 349 procedures, there were two incidents of pneumocephalus diagnosed. Neither of the patients had pre-existing OSA. One in five patients in our study had pre-existing OSA. Most patients returned to CPAP use within several weeks of TSS for resection of a sellar mass. Neither of the patients with pneumocephalus had pre-existing OSA and none of the patients with early re-initiation of CPAP developed this complication. This study provides preliminary evidence that resuming CPAP early in the post-operative period might be less dangerous than previously assumed. Copyright © 2016 Elsevier Ltd. All rights reserved.
Terascale Computing in Accelerator Science and Technology
DOE Office of Scientific and Technical Information (OSTI.GOV)
Ko, Kwok
2002-08-21
We have entered the age of ''terascale'' scientific computing. Processors and system architecture both continue to evolve; hundred-teraFLOP computers are expected in the next few years, and petaFLOP computers toward the end of this decade are conceivable. This ever-increasing power to solve previously intractable numerical problems benefits almost every field of science and engineering and is revolutionizing some of them, notably including accelerator physics and technology. At existing accelerators, it will help us optimize performance, expand operational parameter envelopes, and increase reliability. Design decisions for next-generation machines will be informed by unprecedented comprehensive and accurate modeling, as well as computer-aidedmore » engineering; all this will increase the likelihood that even their most advanced subsystems can be commissioned on time, within budget, and up to specifications. Advanced computing is also vital to developing new means of acceleration and exploring the behavior of beams under extreme conditions. With continued progress it will someday become reasonable to speak of a complete numerical model of all phenomena important to a particular accelerator.« less
The benefit of lithium carbonate adjunct in refractory depression--fact or fiction?
Kantor, D; McNevin, S; Leichner, P; Harper, D; Krenn, M
1986-06-01
Our group attempted to validate previous claims of rapid success with lithium carbonate adjunct therapy in antidepressant-resistant depression. Seven depressed patients volunteered for a study of placebo controlled, double-blind design. During their treatment on general hospital psychiatric wards, these patients received antidepressant medication for a period of at least 21 days. While continuing to receive antidepressant medication after the 21 day period, four of the patients then received lithium carbonate, and three received placebo. This combination pharmacological therapy continued for a 48 hour period. After this time, six of the seven patients showed no significant improvement. The remaining patient, who had received lithium carbonate, improved markedly over the 48 hour period. However, this patient relapsed within one week. A review of the two most extensive studies claiming significant results with the lithium carbonate adjunct therapy was performed. We feel that they, as presented, leave serious doubt as to the validity of their conclusions. We conclude that on the basis of our work up to this point in time and the analysis of previous reports claiming otherwise, no valid evidence exists for a consistent therapeutic effect of lithium carbonate adjunct in antidepressant-resistant depression. It was also found that methodologic contamination necessitated the exclusion of an additional six patients from the double-blind trial. We conclude that in order to objectively examine the rapidly expanding field of biological psychiatry, teaching of clinical staff in basic research procedure should be stressed as a part of routine ward orientation.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Hofmann, S.; Heinz, S.; Mann, R.
The reaction 54Cr$ + $248Cm was investigated at the velocity filter SHIP at GSI, Darmstadt, with the intention to study production and decay properties of isotopes of element 120. Three correlated signals were measured, which occurred within a period of 279ms. The heights of the signals correspond with the expectations for a decay sequence starting with an isotope of element 120. However, a complete decay chain cannot be established, since a signal from the implantation of the evaporation residue cannot be identified unambiguously. Measured properties of the event chain are discussed in detail. The result is compared with theoretical predictions.more » Previously measured decay properties of even element super-heavy nuclei were compiled in order to find arguments for an assignment from the systematics of experimental data. In the course of this review, a few tentatively assigned data could be corrected. New interpretations are given for results which could not be assigned definitely in previous studies. The discussion revealed that the cross-section for production of element 120 could be high enough so that a successful experiment seems possible with presently available techniques. However, a continuation of the experiment at SHIP for a necessary confirmation of the results obtained in a relatively short irradiation of five weeks is not possible at GSI presently. Furthermore, we decided to publish the results of the measurement and of the review as they exist now. In the summary and outlook section we also present concepts for the continuation of research in the field of super-heavy nuclei.« less
NASA Astrophysics Data System (ADS)
Ranti Ristiani, Christina; Rokhmatuloh; Hernina, Revi
2017-12-01
Flood is one of natural disasters that have often happened in East Jakarta. Flood can give several negative impacts and it can affect all aspects of society lives such as economics, political, cultural, socials and others. East Jakarta is an urban area which continuously grows and establishes to become a rapid area. It can be seen from the highest population density in East Jakarta (BPS, 2016) and categorized into a region prone to flooding based on data Prone Flood Map in 1996 and 2016. The higher population exists in East Jakarta, the bigger possibility of the negative effects of disaster it gets. The negative impacts of flood disaster can affect societies especially with socio-economic disadvantage. One of the index to measure socio-economic disadvantage is NSDI (Neighbourhood socio-economic disadvantage index). However, to adjust indicators used in NSDI with Indonesia statistical data compatibility, it needs further assessment and evaluation. Therefore, this paper evaluates previous main indicators used in previous NSDI studies and improves with indicators which more suitable with statistical records in Indonesia. As a result, there will be improved 19 indicators to be used in NSDI, but the groups of indicators remain the same as previous namely; income, education, occupation, housing, and population.
L-Dopa in Parkinsonism and the Influence of Previous Thalamotomy
Hughes, R. C.; Polgar, J. G.; Weightman, D.; Walton, John N.
1971-01-01
A double-blind cross-over trial over 24 weeks (10 weeks on the active remedy, 4 weeks off treatment, and 10 weeks on placebo) of the effect of L-dopa on idiopathic Parkinsonism (paralysis agitans) has shown no difference in the response obtained in patients who had undergone previous stereotaxic ventrolateral thalamotomy and in those who had not. Of the 34 patients (18 men and 16 women) in the trial 18 had been operated on (nine unilateral, nine bilateral operations) and 16 had not. All patients entering the trial were taking anticholinergic drugs in stable dosage and these were continued throughout. The only factor which seemed to limit the response to treatment was pre-existing hypertension. Of 31 patients who completed the 10-week treatment period, 12 showed marked improvement, 15 moderate improvement, and 4 and mild or negligible change. It seems that previous ventrolateral thalamotomy affords some protection against the development of L-dopa-induced involuntary limb movements on the side contralateral to the operation. As found by others, maximum benefit was seen in bradykinesia and rigidity and related features but a significant reduction in tremor was also noted during treatment. Side effects (nausea, hypotension, and involuntary movements) were common but rarely limited the therapeutic response. PMID:4923653
Ashford, Robert D; Brown, Austin M; Curtis, Brenda
2018-06-04
Previous research has found initial evidence that word choice impacts the perception and treatment of those with behavioral health disorders through explicit bias (i.e., stigma). A more robust picture of behavioral health disorder stigma should incorporate both explicit and implicit bias, rather than relying on only one form. The current study uses the Go/No-Go Association Task to calculate a d' (sensitivity) indexed score of automatic attitudes (i.e., implicit associations) to two terms, "addict" and "person with substance use disorder." Participants have significantly more negative automatic attitudes (i.e., implicit bias) toward the term "addict" in isolation as well as when compared to "person with a substance use disorder." Consistent with previous research on explicit bias, implicit bias does exist for terms commonly used in the behavioral health field. "Addict" should not be used in professional or lay settings. Additionally, these results constitute the second pilot study employed the Go/No-Go Association Task in this manner, suggesting it is a viable option for continued linguistic stigma related research.
40 CFR 415.344 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 30 2013-07-01 2012-07-01 true Pretreatment standards for existing... (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS INORGANIC CHEMICALS MANUFACTURING POINT SOURCE CATEGORY Chrome Pigments Production Subcategory § 415.344 Pretreatment standards for existing sources (PSES). (a) Existing...
Accurate path integration in continuous attractor network models of grid cells.
Burak, Yoram; Fiete, Ila R
2009-02-01
Grid cells in the rat entorhinal cortex display strikingly regular firing responses to the animal's position in 2-D space and have been hypothesized to form the neural substrate for dead-reckoning. However, errors accumulate rapidly when velocity inputs are integrated in existing models of grid cell activity. To produce grid-cell-like responses, these models would require frequent resets triggered by external sensory cues. Such inadequacies, shared by various models, cast doubt on the dead-reckoning potential of the grid cell system. Here we focus on the question of accurate path integration, specifically in continuous attractor models of grid cell activity. We show, in contrast to previous models, that continuous attractor models can generate regular triangular grid responses, based on inputs that encode only the rat's velocity and heading direction. We consider the role of the network boundary in the integration performance of the network and show that both periodic and aperiodic networks are capable of accurate path integration, despite important differences in their attractor manifolds. We quantify the rate at which errors in the velocity integration accumulate as a function of network size and intrinsic noise within the network. With a plausible range of parameters and the inclusion of spike variability, our model networks can accurately integrate velocity inputs over a maximum of approximately 10-100 meters and approximately 1-10 minutes. These findings form a proof-of-concept that continuous attractor dynamics may underlie velocity integration in the dorsolateral medial entorhinal cortex. The simulations also generate pertinent upper bounds on the accuracy of integration that may be achieved by continuous attractor dynamics in the grid cell network. We suggest experiments to test the continuous attractor model and differentiate it from models in which single cells establish their responses independently of each other.
Real-time maritime scene simulation for ladar sensors
NASA Astrophysics Data System (ADS)
Christie, Chad L.; Gouthas, Efthimios; Swierkowski, Leszek; Williams, Owen M.
2011-06-01
Continuing interest exists in the development of cost-effective synthetic environments for testing Laser Detection and Ranging (ladar) sensors. In this paper we describe a PC-based system for real-time ladar scene simulation of ships and small boats in a dynamic maritime environment. In particular, we describe the techniques employed to generate range imagery accompanied by passive radiance imagery. Our ladar scene generation system is an evolutionary extension of the VIRSuite infrared scene simulation program and includes all previous features such as ocean wave simulation, the physically-realistic representation of boat and ship dynamics, wake generation and simulation of whitecaps, spray, wake trails and foam. A terrain simulation extension is also under development. In this paper we outline the development, capabilities and limitations of the VIRSuite extensions.
Jet mixing in low gravity - Results of the Tank Pressure Control Experiment
NASA Technical Reports Server (NTRS)
Bentz, M. D.; Meserole, J. S.; Knoll, R. H.
1992-01-01
The Tank Pressure Control Experiment (TPCE) is discussed with attention given to the results for controlling storage-tank pressures by forced-convective mixing in microgravitational environments. The fluid dynamics of cryogenic fluids in space is simulated with freon-113 during axial-jet-induced mixing. The experimental flow-pattern data are found to confirm previous data as well as existing mixing correlations. Thermal nonuniformities and tank pressure can be reduced by employing low-energy mixing jets which are useful for enhancing heat/mass transfer between phases. It is found that space cryogenic systems based on the principle of active mixing can be more reliable and predictable than other methods, and continuous or periodic mixing can be accomplished with only minor energy addition to the fluid.
Three proposals to increase Australia's organ supply.
Isdale, William; Savulescu, Julian
2015-01-01
In 2008 the Australian Government introduced a national reform agenda to increase organ and tissue donation. Australia continues to perform poorly by international standards on measures of organ procurement, however. This paper outlines three proposals to improve donation rates and considers the empirical evidence available for each. A number of ethical objections frequently given to resist such proposals are also addressed. Firstly, it is recommended that Australia implement an 'opt-out' system of organ donation. Secondly, the existing veto rules should be changed to better protect the wishes of those who wish to donate. Finally, a numer of incentives should be offered to increase donation rates; these could include incentives of financial value, but also non-financial incentives such as prioritisation for the receipt of organs for previous donors.
Military duty: risk factor for preterm labor? A review.
McNeary, A M; Lomenick, T S
2000-08-01
The female military population represents a high-risk group for preterm labor and other adverse pregnancy outcomes. As the number of women entering the armed forces continues to increase, concerns regarding the effects of military service on pregnancy must persist. Although active duty females have access to prenatal care and maintain consistent follow-up, previous research has noted a 5-fold increase in preterm labor compared with civilian working women. Hospitalization and loss of work attributable to pregnancy complications directly affect productivity and mission accomplishment; therefore, it is crucial to identify those at risk to institute measures that will prevent such occurrences and decrease time away from work. This article provides a review of the existing literature concerning preterm labor in military women, comparisons with the civilian population, and recommendations for future research.
Diffuse Parenchymal Diseases Associated With Aluminum Use and Primary Aluminum Production
2014-01-01
Aluminum use and primary aluminum production results in the generation of various particles, fumes, gases, and airborne materials with the potential for inducing a wide range of lung pathology. Nevertheless, the presence of diffuse parenchymal or interstitial lung disease related to these processes remains controversial. The relatively uncommon occurrence of interstitial lung diseases in aluminum-exposed workers—despite the extensive industrial use of aluminum—the potential for concurrent exposure to other fibrogenic fibers, and the previous use of inhaled aluminum powder for the prevention of silicosis without apparent adverse respiratory effects are some of the reasons for this continuing controversy. Specific aluminum-induced parenchymal diseases described in the literature, including existing evidence of interstitial lung diseases, associated with primary aluminum production are reviewed. PMID:24806728
Detection of novel gammaherpesviruses from fruit bats in Indonesia.
Wada, Yuji; Sasaki, Michihito; Setiyono, Agus; Handharyani, Ekowati; Rahmadani, Ibenu; Taha, Siswatiana; Adiani, Sri; Latief, Munira; Kholilullah, Zainal Abidin; Subangkit, Mawar; Kobayashi, Shintaro; Nakamura, Ichiro; Kimura, Takashi; Orba, Yasuko; Sawa, Hirofumi
2018-03-01
Bats are an important natural reservoir of zoonotic viral pathogens. We previously isolated an alphaherpesvirus in fruit bats in Indonesia, and here establish the presence of viruses belonging to other taxa of the family Herpesviridae. We screened the same fruit bat population with pan-herpesvirus PCR and discovered 68 sequences of novel gammaherpesvirus, designated 'megabat gammaherpesvirus' (MgGHV). A phylogenetic analysis of approximately 3.4 kbp of continuous MgGHV sequences encompassing the glycoprotein B gene and DNA polymerase gene revealed that the MgGHV sequences are distinct from those of other reported gammaherpesviruses. Further analysis suggested the existence of co-infections of herpesviruses in Indonesian fruit bats. Our findings extend our understanding of the infectious cycles of herpesviruses in bats in Indonesia and the phylogenetic diversity of the gammaherpesviruses.
Constitutive acoustic-emission elastic-stress behavior of magnesium alloy
NASA Technical Reports Server (NTRS)
Williams, J. H., Jr.; Emerson, G. P.
1977-01-01
Repeated laoding and unloading of a magnesium alloy below the macroscopic yield stress result in continuous acoustic emissions which are generally repeatable for a given specimen and which are reproducible between different specimens having the same load history. An acoustic emission Bauschinger strain model is proposed to describe the unloading emission behavior. For the limited range of stress examined, loading and unloading stress delays of the order of 50 MN/sq m are observed, and they appear to be dependent upon the direction of loading, the stress rate, and the stress history. The stress delay is hypothesized to be the manifestation of an effective friction stress. The existence of acoustic emission elastic stress constitutive relations is concluded, which provides support for a previously proposed concept for the monitoring of elastic stresses by acoustic emission.
Long time stability of small-amplitude Breathers in a mixed FPU-KG model
NASA Astrophysics Data System (ADS)
Paleari, Simone; Penati, Tiziano
2016-12-01
In the limit of small couplings in the nearest neighbor interaction, and small total energy, we apply the resonant normal form result of a previous paper of ours to a finite but arbitrarily large mixed Fermi-Pasta-Ulam Klein-Gordon chain, i.e., with both linear and nonlinear terms in both the on-site and interaction potential, with periodic boundary conditions. An existence and orbital stability result for Breathers of such a normal form, which turns out to be a generalized discrete nonlinear Schrödinger model with exponentially decaying all neighbor interactions, is first proved. Exploiting such a result as an intermediate step, a long time stability theorem for the true Breathers of the KG and FPU-KG models, in the anti-continuous limit, is proven.
A 200-Second Quasi-Periodicity After the Tidal Disruption of a Star by a Dormant Black Hole
NASA Technical Reports Server (NTRS)
Reis, R. C.; Miller, J. M.; Reynolds, M. T.; Gueltkinm K.; Maitra, D.; King, A. L.; Strohmayer, T.
2012-01-01
Supermassive black holes are known to exist at the center of most galaxies with sufficient stellar mass, In the local Universe, it is possible to infer their properties from the surrounding stars or gas. However, at high redshifts we require active, continuous accretion to infer the presence of the SMBHs, often coming in the form of long term accretion in active galactic nuclei. SMBHs can also capture and tidally disrupt stars orbiting nearby, resulting in bright flares from otherwise quiescent black holes. Here, we report on a approx.200-s X-ray quasi-periodicity around a previously dormant SMBH located in the center of a galaxy at redshift z = 0.3534. This result may open the possibility of probing general relativity beyond our local Universe.
Characterization and solvability of quasipolynomial symplectic mappings
NASA Astrophysics Data System (ADS)
Hernández-Bermejo, Benito; Brenig, Léon
2004-02-01
Quasipolynomial (or QP) mappings constitute a wide generalization of the well-known Lotka-Volterra mappings, of importance in different fields such as population dynamics, physics, chemistry or economy. In addition, QP mappings are a natural discrete-time analogue of the continuous QP systems, which have been extensively used in different pure and applied domains. After presenting the basic definitions and properties of QP mappings in a previous paper [1], the purpose of this work is to focus on their characterization by considering the existence of symplectic QP mappings. In what follows such QP symplectic maps are completely characterized. Moreover, use of the QP formalism can be made in order to demonstrate that all QP symplectic mappings have an analytical solution that is explicitly and generally constructed. Examples are given.
Approximating scatterplots of large datasets using distribution splats
NASA Astrophysics Data System (ADS)
Camuto, Matthew; Crawfis, Roger; Becker, Barry G.
2000-02-01
Many situations exist where the plotting of large data sets with categorical attributes is desired in a 3D coordinate system. For example, a marketing company may conduct a survey involving one million subjects and then plot peoples favorite car type against their weight, height and annual income. Scatter point plotting, in which each point is individually plotted at its correspond cartesian location using a defined primitive, is usually used to render a plot of this type. If the dependent variable is continuous, we can discretize the 3D space into bins or voxels and retain the average value of all records falling within each voxel. Previous work employed volume rendering techniques, in particular, splatting, to represent this aggregated data, by mapping each average value to a representative color.
The Economic and Social Value of an Image Exchange Network: A Case for the Cloud.
Mayo, Ray Cody; Pearson, Kathryn L; Avrin, David E; Leung, Jessica W T
2017-01-01
As the health care environment continually changes, radiologists look to the ACR's Imaging 3.0 ® initiative to guide the search for value. By leveraging new technology, a cloud-based image exchange network could provide secure universal access to prior images, which were previously siloed, to facilitate accurate interpretation, improved outcomes, and reduced costs. The breast imaging department represents a viable starting point given the robust data supporting the benefit of access to prior imaging studies, existing infrastructure for image sharing, and the current workflow reliance on prior images. This concept is scalable not only to the remainder of the radiology department but also to the broader medical record. Copyright © 2016 American College of Radiology. Published by Elsevier Inc. All rights reserved.
1983-01-01
considered important, complete, and a lasting contribution to existing knowledge. -’ Mechanical Engineering Reports (MS): Scientific and technical information...pertaining to investigations outside aeronautics considered important, complete, and a lasting contribution to existing knowledge. * AERONAUTICAL...NOTES (AN): Information les~s broad in scope but nevertheless of importance as a * contribution to existing knowledge. LABORATORY TECHNICAL REPORTS (LTR
Chen, Xiaofeng; Song, Qiankun; Li, Zhongshan; Zhao, Zhenjiang; Liu, Yurong
2018-07-01
This paper addresses the problem of stability for continuous-time and discrete-time quaternion-valued neural networks (QVNNs) with linear threshold neurons. Applying the semidiscretization technique to the continuous-time QVNNs, the discrete-time analogs are obtained, which preserve the dynamical characteristics of their continuous-time counterparts. Via the plural decomposition method of quaternion, homeomorphic mapping theorem, as well as Lyapunov theorem, some sufficient conditions on the existence, uniqueness, and global asymptotical stability of the equilibrium point are derived for the continuous-time QVNNs and their discrete-time analogs, respectively. Furthermore, a uniform sufficient condition on the existence, uniqueness, and global asymptotical stability of the equilibrium point is obtained for both continuous-time QVNNs and their discrete-time version. Finally, two numerical examples are provided to substantiate the effectiveness of the proposed results.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 7 2013-07-01 2013-07-01 false Model Rule-Emission Limits and Standards for Existing Multiple Hearth Sewage Sludge Incineration Units 3 Table 3 to Subpart MMMM of Part 60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF...
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 7 2014-07-01 2014-07-01 false Model Rule-Emission Limits and Standards for Existing Fluidized Bed Sewage Sludge Incineration Units 2 Table 2 to Subpart MMMM of Part 60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF...
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 7 2014-07-01 2014-07-01 false Model Rule-Emission Limits and Standards for Existing Multiple Hearth Sewage Sludge Incineration Units 3 Table 3 to Subpart MMMM of Part 60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF...
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 7 2013-07-01 2013-07-01 false Model Rule-Emission Limits and Standards for Existing Fluidized Bed Sewage Sludge Incineration Units 2 Table 2 to Subpart MMMM of Part 60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF...
40 CFR 63.2480 - What requirements must I meet for equipment leaks?
Code of Federal Regulations, 2013 CFR
2013-07-01
... connectors at your affected source. (5) For pumps in light liquid service in an MCPU that has no continuous... connectors in gas/vapor and light liquid service at an existing source, you may elect to comply with the... in light liquid service in an MCPU that has no continuous process vents and is part of an existing...
40 CFR 63.2480 - What requirements must I meet for equipment leaks?
Code of Federal Regulations, 2014 CFR
2014-07-01
... connectors at your affected source. (5) For pumps in light liquid service in an MCPU that has no continuous... connectors in gas/vapor and light liquid service at an existing source, you may elect to comply with the... in light liquid service in an MCPU that has no continuous process vents and is part of an existing...
40 CFR 63.2480 - What requirements must I meet for equipment leaks?
Code of Federal Regulations, 2012 CFR
2012-07-01
... connectors at your affected source. (5) For pumps in light liquid service in an MCPU that has no continuous... connectors in gas/vapor and light liquid service at an existing source, you may elect to comply with the... in light liquid service in an MCPU that has no continuous process vents and is part of an existing...
40 CFR 63.2480 - What requirements must I meet for equipment leaks?
Code of Federal Regulations, 2011 CFR
2011-07-01
... affected source. (5) For pumps in light liquid service in an MCPU that has no continuous process vents and.../vapor and light liquid service at an existing source, you may elect to comply with the requirements in... light liquid service in an MCPU that has no continuous process vents and is part of an existing source...
Continuous-time safety-first portfolio selection with jump-diffusion processes
NASA Astrophysics Data System (ADS)
Yan, Wei
2012-04-01
This article is concerned with continuous-time portfolio selection based on a safety-first criterion under discontinuous price processes (jump-diffusion processes). The solution of the corresponding Hamilton-Jacobi-Bellman equation of the problem is demonstrated. The analytical solutions are presented when there does not exist any riskless asset. Moreover, the problem is also discussed while there exists one riskless asset.
40 CFR 258.16 - Closure of existing municipal solid waste landfill units.
Code of Federal Regulations, 2011 CFR
2011-07-01
... (CONTINUED) SOLID WASTES CRITERIA FOR MUNICIPAL SOLID WASTE LANDFILLS Location Restrictions § 258.16 Closure of existing municipal solid waste landfill units. (a) Existing MSWLF units that cannot make the... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Closure of existing municipal solid...
40 CFR 258.16 - Closure of existing municipal solid waste landfill units.
Code of Federal Regulations, 2010 CFR
2010-07-01
... (CONTINUED) SOLID WASTES CRITERIA FOR MUNICIPAL SOLID WASTE LANDFILLS Location Restrictions § 258.16 Closure of existing municipal solid waste landfill units. (a) Existing MSWLF units that cannot make the... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Closure of existing municipal solid...
10 CFR 611.206 - Existing facilities.
Code of Federal Regulations, 2013 CFR
2013-01-01
... 10 Energy 4 2013-01-01 2013-01-01 false Existing facilities. 611.206 Section 611.206 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS ADVANCED TECHNOLOGY VEHICLES MANUFACTURER ASSISTANCE PROGRAM Facility/Funding Awards § 611.206 Existing facilities. The Secretary shall, in making awards to those manufacturers that have existing...
10 CFR 611.206 - Existing facilities.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 10 Energy 4 2011-01-01 2011-01-01 false Existing facilities. 611.206 Section 611.206 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS ADVANCED TECHNOLOGY VEHICLES MANUFACTURER ASSISTANCE PROGRAM Facility/Funding Awards § 611.206 Existing facilities. The Secretary shall, in making awards to those manufacturers that have existing...
10 CFR 611.206 - Existing facilities.
Code of Federal Regulations, 2014 CFR
2014-01-01
... 10 Energy 4 2014-01-01 2014-01-01 false Existing facilities. 611.206 Section 611.206 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS ADVANCED TECHNOLOGY VEHICLES MANUFACTURER ASSISTANCE PROGRAM Facility/Funding Awards § 611.206 Existing facilities. The Secretary shall, in making awards to those manufacturers that have existing...
10 CFR 611.206 - Existing facilities.
Code of Federal Regulations, 2012 CFR
2012-01-01
... 10 Energy 4 2012-01-01 2012-01-01 false Existing facilities. 611.206 Section 611.206 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS ADVANCED TECHNOLOGY VEHICLES MANUFACTURER ASSISTANCE PROGRAM Facility/Funding Awards § 611.206 Existing facilities. The Secretary shall, in making awards to those manufacturers that have existing...
Global malaria connectivity through air travel.
Huang, Zhuojie; Tatem, Andrew J
2013-08-02
Air travel has expanded at an unprecedented rate and continues to do so. Its effects have been seen on malaria in rates of imported cases, local outbreaks in non-endemic areas and the global spread of drug resistance. With elimination and global eradication back on the agenda, changing levels and compositions of imported malaria in malaria-free countries, and the threat of artemisinin resistance spreading from Southeast Asia, there is a need to better understand how the modern flow of air passengers connects each Plasmodium falciparum- and Plasmodium vivax-endemic region to the rest of the world. Recently constructed global P. falciparum and P.vivax malaria risk maps, along with data on flight schedules and modelled passenger flows across the air network, were combined to describe and quantify global malaria connectivity through air travel. Network analysis approaches were then utilized to describe and quantify the patterns that exist in passenger flows weighted by malaria prevalence. Finally, the connectivity within and to the Southeast Asia region where the threat of imported artemisinin resistance arising is highest, was examined to highlight risk routes for its spread. The analyses demonstrate the substantial connectivity that now exists between and from malaria-endemic regions through air travel. While the air network provides connections to previously isolated malarious regions, it is clear that great variations exist, with significant regional communities of airports connected by higher rates of flow standing out. The structures of these communities are often not geographically coherent, with historical, economic and cultural ties evident, and variations between P. falciparum and P. vivax clear. Moreover, results highlight how well connected the malaria-endemic areas of Africa are now to Southeast Asia, illustrating the many possible routes that artemisinin-resistant strains could take. The continuing growth in air travel is playing an important role in the global epidemiology of malaria, with the endemic world becoming increasingly connected to both malaria-free areas and other endemic regions. The research presented here provides an initial effort to quantify and analyse the connectivity that exists across the malaria-endemic world through air travel, and provide a basic assessment of the risks it results in for movement of infections.
Global malaria connectivity through air travel
2013-01-01
Background Air travel has expanded at an unprecedented rate and continues to do so. Its effects have been seen on malaria in rates of imported cases, local outbreaks in non-endemic areas and the global spread of drug resistance. With elimination and global eradication back on the agenda, changing levels and compositions of imported malaria in malaria-free countries, and the threat of artemisinin resistance spreading from Southeast Asia, there is a need to better understand how the modern flow of air passengers connects each Plasmodium falciparum- and Plasmodium vivax-endemic region to the rest of the world. Methods Recently constructed global P. falciparum and P.vivax malaria risk maps, along with data on flight schedules and modelled passenger flows across the air network, were combined to describe and quantify global malaria connectivity through air travel. Network analysis approaches were then utilized to describe and quantify the patterns that exist in passenger flows weighted by malaria prevalence. Finally, the connectivity within and to the Southeast Asia region where the threat of imported artemisinin resistance arising is highest, was examined to highlight risk routes for its spread. Results The analyses demonstrate the substantial connectivity that now exists between and from malaria-endemic regions through air travel. While the air network provides connections to previously isolated malarious regions, it is clear that great variations exist, with significant regional communities of airports connected by higher rates of flow standing out. The structures of these communities are often not geographically coherent, with historical, economic and cultural ties evident, and variations between P. falciparum and P. vivax clear. Moreover, results highlight how well connected the malaria-endemic areas of Africa are now to Southeast Asia, illustrating the many possible routes that artemisinin-resistant strains could take. Discussion The continuing growth in air travel is playing an important role in the global epidemiology of malaria, with the endemic world becoming increasingly connected to both malaria-free areas and other endemic regions. The research presented here provides an initial effort to quantify and analyse the connectivity that exists across the malaria-endemic world through air travel, and provide a basic assessment of the risks it results in for movement of infections. PMID:23914776
Federal Register 2010, 2011, 2012, 2013, 2014
2010-03-26
... (Business Continuity and Contingency Plans) and adopt new Rule 4370--NYSE Amex Equities (Business Continuity... Continuity and Contingency Plans) as substantively duplicative of NASD Rules 3510 (Business Continuity Plans... Equities (Business Continuity and Contingency Plans) to remove the existing text and incorporate NASD Rules...
A quantitative study of the summer slide in science of elementary school students
NASA Astrophysics Data System (ADS)
Donovan, Giovanna Guadagno
Concerned parents and educators agree children learn best when the rhythm of instruction is continuous with practice and application of skills. Long summer breaks may interrupt the flow of formal school learning leading some students to forget previous instruction. A review of the previous school work is generally required in the fall upon return from the summer vacation. Investigating summer vacation and equity issues, Jamar (1994) noted that more affluent students may "return to school in the fall with a considerable educational advantage over their less advantaged peers as a result of either additional school-related learning, or lower levels of forgetting, over the summer months (p. 1)". The population of 402 fifth grade students from a suburban New England school district participated in this study. The district administered the science subtest of the TerraNova 2 (TN2) assessment in late May 2007 (pre-test data) and in September 2007 (post-test data). These archived data, including gender and student socioeconomic status (SES) levels (as referenced by free or reduced lunch status), were analyzed for an ex-post facto causal comparison study to identify the phenomenon of summer slide in science of fifth graders enrolled in six elementary schools. The ANOVA statistical model was used calculating the repeated measures factor of time (pre/post summer vacation) on the science content area. Subsequent two-way ANOVAS, with one repeated-measures factor (time of testing) explored the existence of similar/different patterns by gender and by SES levels. Two questions guided this study. First, does the summer slide phenomenon exist in science education? Second, if the summer slide in science phenomenon exists in science education, then does SES impact it? Does the summer slide in science phenomenon differ between genders? Findings suggest that the summer slide phenomenon exists in science; SES and gender does not affect the overall science test scores. However, SES impacts the summer slide phenomenon in science but gender does not impact summer slide in science. Furthermore, the school does not statistically impact the summer slide phenomenon in science and the impact of school does not differ across SES and genders.
Murchie, Brent; Tandon, Kanwarpreet; Hakim, Seifeldin; Shah, Kinchit; O'Rourke, Colin; Castro, Fernando J
2017-04-01
Colorectal cancer (CRC) screening guidelines likely over-generalizes CRC risk, 35% of Americans are not up to date with screening, and there is growing incidence of CRC in younger patients. We developed a practical prediction model for high-risk colon adenomas in an average-risk population, including an expanded definition of high-risk polyps (≥3 nonadvanced adenomas), exposing higher than average-risk patients. We also compared results with previously created calculators. Patients aged 40 to 59 years, undergoing first-time average-risk screening or diagnostic colonoscopies were evaluated. Risk calculators for advanced adenomas and high-risk adenomas were created based on age, body mass index, sex, race, and smoking history. Previously established calculators with similar risk factors were selected for comparison of concordance statistic (c-statistic) and external validation. A total of 5063 patients were included. Advanced adenomas, and high-risk adenomas were seen in 5.7% and 7.4% of the patient population, respectively. The c-statistic for our calculator was 0.639 for the prediction of advanced adenomas, and 0.650 for high-risk adenomas. When applied to our population, all previous models had lower c-statistic results although one performed similarly. Our model compares favorably to previously established prediction models. Age and body mass index were used as continuous variables, likely improving the c-statistic. It also reports absolute predictive probabilities of advanced and high-risk polyps, allowing for more individualized risk assessment of CRC.
NASA Astrophysics Data System (ADS)
Zhongjie, Y.; Schafer, K. V.; Slater, L. D.; Varner, R. K.; Amante, J.; Comas, X.; Reeve, A. S.; Alcivar, W.; Gonzalez, D.
2012-12-01
Northern peatlands are an important source of methane (CH4) release to the atmosphere, estimated at between 20 and 50 Tg/yr. Recent work on CH4 emissions from peatlands has demonstrated that ebullition can be a more important emission pathway than previously assumed. However, accurate quantification of the atmospheric CH4 burden due to ebullition is still very limited because ebullition exhibits high spatiotemporal variability such that sudden episodic events are difficult to capture and quantify with existing experimental methods. We have initiated a novel measurement program to better quantify the spatiotemporal variability in CH4 flux in peatlands, and to examine potential effects of vegetation and environmental factors, e.g. atmospheric pressure, water table, etc on these releases. A flow-through system was designed, consisting of a closed static chamber and a fast methane analyzer (FMA) (LI-COR model 7700) that has been employed at both the field and laboratory scale. The CH4 concentration in the air flowing through the chamber is continuously measured by the analyzer and used to reconstruct continuous CH4 emission fluxes. The high sampling rate of the FMA makes it sensitive to both ebullition and diffusion of gaseous CH4, capturing short duration, episodic ebullition fluxes. Non-steady static chamber measurements were also conducted to cross-validate the continuous measurements. Results acquired during summer 2011 show that episodic ebullition occurred more frequently at the pool site where previous studies indicate extensive wood layers at depth and the vegetation was a mix of Sphagnum and wooded heath. During a 3 day period of continuous measurements captured the passage of a tropical storm Irene, where short term episodic releases of CH4, ranging from 113 mg CH4/m2/d to 202 mg CH4/m2/d, were observed at the time of lowest atmospheric pressure, providing new evidence that atmospheric pressure is an important factor to controlling CH4 ebullition from peatlands. While traditional techniques, e.g. static chamber measurement can only occasionally detect the occurrence of ebullition, the continuous measurement by using a flow-through system is able to resolve spatiotemporal complexity of episodic CH4 ebullition events. These continuous CH4 measurements provide new insights into the timing of CH4 ebullition from peatlands to the atmosphere as climate changes and the role of environmental variables in regulating these CH4 releases.
20 CFR 416.1337 - Exceptions to the continuation of previously established payment level.
Code of Federal Regulations, 2014 CFR
2014-04-01
... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Exceptions to the continuation of previously established payment level. 416.1337 Section 416.1337 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Suspensions and Terminations § 416.1337...
Man, mind, and machine: the past and future of virtual reality simulation in neurologic surgery.
Robison, R Aaron; Liu, Charles Y; Apuzzo, Michael L J
2011-11-01
To review virtual reality in neurosurgery, including the history of simulation and virtual reality and some of the current implementations; to examine some of the technical challenges involved; and to propose a potential paradigm for the development of virtual reality in neurosurgery going forward. A search was made on PubMed using key words surgical simulation, virtual reality, haptics, collision detection, and volumetric modeling to assess the current status of virtual reality in neurosurgery. Based on previous results, investigators extrapolated the possible integration of existing efforts and potential future directions. Simulation has a rich history in surgical training, and there are numerous currently existing applications and systems that involve virtual reality. All existing applications are limited to specific task-oriented functions and typically sacrifice visual realism for real-time interactivity or vice versa, owing to numerous technical challenges in rendering a virtual space in real time, including graphic and tissue modeling, collision detection, and direction of the haptic interface. With ongoing technical advancements in computer hardware and graphic and physical rendering, incremental or modular development of a fully immersive, multipurpose virtual reality neurosurgical simulator is feasible. The use of virtual reality in neurosurgery is predicted to change the nature of neurosurgical education, and to play an increased role in surgical rehearsal and the continuing education and credentialing of surgical practitioners. Copyright © 2011 Elsevier Inc. All rights reserved.
Towards a Comprehensive Catalog of Volcanic Seismicity
NASA Astrophysics Data System (ADS)
Thompson, G.
2014-12-01
Catalogs of earthquakes located using differential travel-time techniques are a core product of volcano observatories, and while vital, they represent an incomplete perspective of volcanic seismicity. Many (often most) earthquakes are too small to locate accurately, and are omitted from available catalogs. Low frequency events, tremor and signals related to rockfalls, pyroclastic flows and lahars are not systematically catalogued, and yet from a hazard management perspective are exceedingly important. Because STA/LTA detection schemes break down in the presence of high amplitude tremor, swarms or dome collapses, catalogs may suggest low seismicity when seismicity peaks. We propose to develop a workflow and underlying software toolbox that can be applied to near-real-time and offline waveform data to produce comprehensive catalogs of volcanic seismicity. Existing tools to detect and locate phaseless signals will be adapted to fit within this framework. For this proof of concept the toolbox will be developed in MATLAB, extending the existing GISMO toolbox (an object-oriented MATLAB toolbox for seismic data analysis). Existing database schemas such as the CSS 3.0 will need to be extended to describe this wider range of volcano-seismic signals. WOVOdat may already incorporate many of the additional tables needed. Thus our framework may act as an interface between volcano observatories (or campaign-style research projects) and WOVOdat. We aim to take the further step of reducing volcano-seismic catalogs to sets of continuous metrics that are useful for recognizing data trends, and for feeding alarm systems and forecasting techniques. Previous experience has shown that frequency index, peak frequency, mean frequency, mean event rate, median event rate, and cumulative magnitude (or energy) are potentially useful metrics to generate for all catalogs at a 1-minute sample rate (directly comparable with RSAM and similar metrics derived from continuous data). Our framework includes tools to plot these metrics in a consistent manner. We work with data from unrest at Redoubt volcano and Soufriere Hills volcano to develop our framework.
12 CFR 563b.435 - What happens to my corporate existence after conversion?
Code of Federal Regulations, 2010 CFR
2010-01-01
... 12 Banks and Banking 5 2010-01-01 2010-01-01 false What happens to my corporate existence after... What happens to my corporate existence after conversion? Your corporate existence will continue following your conversion, unless you convert to a state-chartered stock savings association and state law...
Auditory traits of "own voice".
Kimura, Marino; Yotsumoto, Yuko
2018-01-01
People perceive their recorded voice differently from their actively spoken voice. The uncanny valley theory proposes that as an object approaches humanlike characteristics, there is an increase in the sense of familiarity; however, eventually a point is reached where the object becomes strangely similar and makes us feel uneasy. The feeling of discomfort experienced when people hear their recorded voice may correspond to the floor of the proposed uncanny valley. To overcome the feeling of eeriness of own-voice recordings, previous studies have suggested equalization of the recorded voice with various types of filters, such as step, bandpass, and low-pass, yet the effectiveness of these filters has not been evaluated. To address this, the aim of experiment 1 was to identify what type of voice recording was the most representative of one's own voice. The voice recordings were presented in five different conditions: unadjusted recorded voice, step filtered voice, bandpass filtered voice, low-pass filtered voice, and a voice for which the participants freely adjusted the parameters. We found large individual differences in the most representative own-voice filter. In order to consider roles of sense of agency, experiment 2 investigated if lip-synching would influence the rating of own voice. The result suggested lip-synching did not affect own voice ratings. In experiment 3, based on the assumption that the voices used in previous experiments corresponded to continuous representations of non-own voice to own voice, the existence of an uncanny valley was examined. Familiarity, eeriness, and the sense of own voice were rated. The result did not support the existence of an uncanny valley. Taken together, the experiments led us to the following conclusions: there is no general filter that can represent own voice for everyone, sense of agency has no effect on own voice rating, and the uncanny valley does not exist for own voice, specifically.
Continuous flow technology vs. the batch-by-batch approach to produce pharmaceutical compounds.
Cole, Kevin P; Johnson, Martin D
2018-01-01
For the manufacture of small molecule drugs, many pharmaceutical innovator companies have recently invested in continuous processing, which can offer significant technical and economic advantages over traditional batch methodology. This Expert Review will describe the reasons for this interest as well as many considerations and challenges that exist today concerning continuous manufacturing. Areas covered: Continuous processing is defined and many reasons for its adoption are described. The current state of continuous drug substance manufacturing within the pharmaceutical industry is summarized. Current key challenges to implementation of continuous manufacturing are highlighted, and an outlook provided regarding the prospects for continuous within the industry. Expert commentary: Continuous processing at Lilly has been a journey that started with the need for increased safety and capability. Over twelve years the original small, dedicated group has grown to more than 100 Lilly employees in discovery, development, quality, manufacturing, and regulatory designing in continuous drug substance processing. Recently we have focused on linked continuous unit operations for the purpose of all-at-once pharmaceutical manufacturing, but the technical and business drivers that existed in the very beginning for stand-alone continuous unit operations in hybrid processes have persisted, which merits investment in both approaches.
Correlation, evaluation, and extension of linearized theories for tire motion and wheel shimmy
NASA Technical Reports Server (NTRS)
Smiley, Robert F
1957-01-01
An evaluation is made of the existing theories of a linearized tire motion and wheel shimmy. It is demonstrated that most of the previously published theories represent varying degrees of approximation to a summary theory developed in this report which is a minor modification of the basic theory of Von Schlippe and Dietrich. In most cases where strong differences exist between the previously published theories and summary theory, the previously published theories are shown to possess certain deficiencies. A series of systematic approximations to the summary theory is developed for the treatment of problems too simple to merit the use of the complete summary theory, and procedures are discussed for applying the summary theory and its systematic approximations to the shimmy of more complex landing-gear structures than have previously been considered. Comparisons of the existing experimental data with the predictions of the summary theory and the systematic approximations provide a fair substantiation of the more detailed approximate theories.
Gender and the experience of moral distress in critical care nurses.
O'Connell, Christopher B
2015-02-01
Nursing practice is complex, as nurses are challenged by increasingly intricate moral and ethical judgments. Inadequately studied in underrepresented groups in nursing, moral distress is a serious problem internationally for healthcare professionals with deleterious effects to patients, nurses, and organizations. Moral distress among nurses has been shown to contribute to decreased job satisfaction and increased turnover, withdrawal from patients, physical and psychological symptoms, and intent to leave current position or to leave the profession altogether. Do significant gender differences exist in the moral distress scores of critical care nurses? This study utilized a quantitative, descriptive methodology to explore moral distress levels in a sample of critical care nurses to determine whether gender differences exist in their mean moral distress scores. Participants (n = 31) were critical care nurses from an American Internet nursing community who completed the Moral Distress Scale-Revised online over a 5-day period in July 2013. Institutional review board review approved the study, and accessing and completing the survey implied informed consent. The results revealed a statistically significant gender difference in the mean moral distress scores of participants. Females reported statistically significantly higher moral distress scores than did males. Overall, the moral distress scores for both groups were relatively low. The findings of a gender difference have not previously been reported in the literature. However, other findings are consistent with previous studies on moral distress. Although the results of this study are not generalizable, they do suggest the need for continuing research on moral distress in underrepresented groups in nursing, including cultural and ethnic groups. © The Author(s) 2014.
[Determining factors in the sedation of geriatric and oncology patients treated at home].
Zamora-Mur, A; García-Foncillas, R; Zamora-Catevilla, A; Nabal-Vicuña, M; Calderero-Aragón, V; Lostalé-Latorre, F
2017-04-01
Sedation, used as a therapeutic measure in the field of Palliative Care, continues to present difficulties for many professionals in its management and indications. Is varied existing literature in this regard, often exclusive cancer patients. Our objective is to analyse the characteristics of patients attended by a Home Care Support Team who required sedation compared to non-sedated patients, for possible determining factors for its use that could help in decision-making. A prospective analytical study conducted in Barbastro (Huesca) from September 2007 to February 2011. The study population are patients referred to the Home Care Support Team of Barbastro. Age, sex, medical history, symptoms, previous and current Barthel, Karnofsky, primary caregiver, previous drugs, drugs after intervention, sedation yes/no. Required sedation 16.6% (n=106) of the cases (N=638). Sedated patients were younger, with no differences in sex, and the large majority (83%) were oncology patients. The presence of metastases showed no differences in need for sedation. Sedated patients have an increased functional impairment, determined by Barthel index decreased and a worse Karnofsky. Sedated patients showed increased frequency of uncontrolled symptoms, except psychomotor agitation, a fact determined by the medications used pre- and post-intervention. The presence of neoplastic disease, marked with existence of functional decline, and uncontrolled clinical need for certain medications to control symptoms may determine the need for sedation at the end of the process, above other factors such as patient comorbidity. Copyright © 2016 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España, S.L.U. All rights reserved.
Stabilizing and destabilizing effects of damping in non-conservative systems: Some new results
NASA Astrophysics Data System (ADS)
Abdullatif, Mahmoud; Mukherjee, Ranjan; Hellum, Aren
2018-01-01
Previous work has amply demonstrated that non-conservative systems can be made unstable by the application of damping. Systems with two neutrally-stable damping levels, whereby the system initially gains stability but later loses stability as the level of damping is increased, have also been observed. The phenomenon of three damping-induced stability transitions has not been reported in the literature. Here we show that the addition of damping can cause non-conservative systems to become stable, then unstable, then stable again at the same value of the non-conservative forcing variable. This combination of stability transitions is found to exist for several example systems, including linkages with follower end forces and fluid-conveying pipes. Another interesting observation is that a given system can exhibit different forms of stability transitions in different regions of its parameter space. In a particular example, the neutral stability curves corresponding to two different modes are observed to intersect, such that the boundary separating the stable and unstable regions is piecewise continuous. This observation requires that the accepted definitions of "stabilizing" and "destabilizing" roles of damping be revised. All of these stability transition behaviors were found by applying the Routh-Hurwitz procedure, whereby the traditional procedure is first applied to the characteristic polynomial of the system, and then again to guarantee the existence of a second-order auxiliary polynomial in the Routh array. This procedure is developed in the context of examples, each of which concerns a classical apparatus who dynamics are more interesting than previously believed.
NASA Astrophysics Data System (ADS)
Zhou, distributed delays [rapid communication] T.; Chen, A.; Zhou, Y.
2005-08-01
By using the continuation theorem of coincidence degree theory and Liapunov function, we obtain some sufficient criteria to ensure the existence and global exponential stability of periodic solution to the bidirectional associative memory (BAM) neural networks with periodic coefficients and continuously distributed delays. These results improve and generalize the works of papers [J. Cao, L. Wang, Phys. Rev. E 61 (2000) 1825] and [Z. Liu, A. Chen, J. Cao, L. Huang, IEEE Trans. Circuits Systems I 50 (2003) 1162]. An example is given to illustrate that the criteria are feasible.
Modes of supraglacial lake drainage and dynamic ice sheet response
NASA Astrophysics Data System (ADS)
Das, S. B.; Behn, M. D.; Joughin, I. R.
2011-12-01
We investigate modes of supraglacial lake drainage using geophysical, ground, and remote sensing observations over the western margin of the Greenland ice sheet. Lakes exhibit a characteristic life cycle defined by a pre-drainage, drainage, and post-drainage phase. In the pre-drainage phase winter snow fills pre-existing cracks and stream channels, efficiently blocking past drainage conduits. As temperatures increase in the spring, surface melting commences, initially saturating the snow pack and subsequently forming a surface network of streams that fills the lake basins. Basins continue to fill until lake drainage commences, which for individual lakes occurs at different times depending on the previous winter snow accumulation and summer temperatures. Three styles of drainage behavior have been observed: (1) no drainage, (2) slow drainage over the side into an adjacent pre-existing crack, and (3) rapid drainage through a new crack formed beneath the lake basin. Moreover, from year-to-year individual lakes exhibit different drainage behaviors. Lakes that drain slowly often utilize the same outflow channel for multiple years, creating dramatic canyons in the ice. Ultimately, these surface channels are advected out of the lake basin and a new channel forms. In the post-drainage phase, melt water continues to access the bed typically through a small conduit (e.g. moulin) formed near a local topographic minimum along the main drainage crack, draining the lake catchment throughout the remainder of the melt season. This melt water input to the bed leads to continued basal lubrication and enhanced ice flow compared to background velocities. Lakes that do not completely drain freeze over to form a surface ice layer that persists into the following year. Our results show that supraglacial lakes show a spectrum of drainage behaviors and that these styles of drainage lead to varying rates and timing of surface meltwater delivery to the bed resulting in different dynamic ice responses.
33 CFR 175.135 - Existing equipment.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Existing equipment. 175.135 Section 175.135 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY EQUIPMENT REQUIREMENTS Visual Distress Signals § 175.135 Existing equipment. Launchers...
33 CFR 175.135 - Existing equipment.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Existing equipment. 175.135 Section 175.135 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY EQUIPMENT REQUIREMENTS Visual Distress Signals § 175.135 Existing equipment. Launchers...
33 CFR 175.135 - Existing equipment.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Existing equipment. 175.135 Section 175.135 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY EQUIPMENT REQUIREMENTS Visual Distress Signals § 175.135 Existing equipment. Launchers...
33 CFR 175.135 - Existing equipment.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Existing equipment. 175.135 Section 175.135 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY EQUIPMENT REQUIREMENTS Visual Distress Signals § 175.135 Existing equipment. Launchers...
33 CFR 175.135 - Existing equipment.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Existing equipment. 175.135 Section 175.135 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY EQUIPMENT REQUIREMENTS Visual Distress Signals § 175.135 Existing equipment. Launchers...
47 CFR 54.604 - Consortia, telecommunications services, and existing contracts.
Code of Federal Regulations, 2014 CFR
2014-10-01
... 47 Telecommunication 3 2014-10-01 2014-10-01 false Consortia, telecommunications services, and existing contracts. 54.604 Section 54.604 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED... Telecommunications Program § 54.604 Consortia, telecommunications services, and existing contracts. (a) Consortia. (1...
47 CFR 54.604 - Consortia, telecommunications services, and existing contracts.
Code of Federal Regulations, 2013 CFR
2013-10-01
... 47 Telecommunication 3 2013-10-01 2013-10-01 false Consortia, telecommunications services, and existing contracts. 54.604 Section 54.604 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED... Telecommunications Program § 54.604 Consortia, telecommunications services, and existing contracts. (a) Consortia. (1...
26 CFR 1.996-4 - Subsequent effect of previous disposition of DISC stock.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 26 Internal Revenue 10 2010-04-01 2010-04-01 false Subsequent effect of previous disposition of DISC stock. 1.996-4 Section 1.996-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Domestic International Sales Corporations § 1.996...
5 CFR 831.616 - Elections by previously retired retiree with new title to an annuity.
Code of Federal Regulations, 2010 CFR
2010-01-01
... MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) RETIREMENT Survivor Annuities Elections at the Time of Retirement § 831.616 Elections by previously retired retiree with new title to an annuity. (a....622 at the time of the redetermination. (b) A disability retiree who recovers from disability or is...
Kerr, David; Olateju, Tolu
2010-06-01
Pascal's Wager is a suggestion posed by the French Philosopher, Blaise Pascal, that even though the existence of God cannot be determined through reason, a person should wager that God exists because he or she has everything to gain and nothing to lose. In the area of consideration here, the optimum experimental trial of the combined use of continuous subcutaneous insulin infusion and real-time continuous glucose monitoring in free-living individuals with type 1 diabetes providing rock-solid evidence of clinical benefit has not been performed. Nevertheless, there is considerable enthusiasm for combining the technologies among healthcare professionals, patients, and manufacturers based on the belief that this approach to diabetes care must be beneficial beyond the available evidence (i.e., reason).
NASA Astrophysics Data System (ADS)
Blume, F.; Miller, M.; Boyce, E.; Borsa, A.; Eriksson, S.
2008-12-01
Tectonic and earthquake research in the US has experienced a quiet revolution over the last decade precipitated by the recognition that slow-motion faulting events can both trigger and be triggered by regular earthquakes. Transient motion has now been found in essentially all tectonic environments, and the detection and analysis of such events is the first-order science target of the EarthScope Project. Because of this and a host of other fundamental tectonics questions that can be answered only with long-duration geodetic time series, the 1100-station EarthScope Plate Boundary Observatory (PBO) network was designed to leverage 445 existing continuous GPS stations whose measurements extend back over a decade. The irreplaceable recording history of these stations will accelerate EarthScope scientific return by providing the highest possible resolution. This resolution will be used to detect and understand transients, to determine the three-dimensional velocity field (particularly vertical motion), and to improve measurement precision by understanding the complex noise sources inherent in GPS. The PBO Nucleus project supports the operation, maintenance and hardware upgrades of a subset of the six western U.S. geodetic networks until they are subsumed by PBO. Uninterrupted data flow from these stations will effectively double the time-series length of PBO over the expected life of EarthScope, and has created, for the first time, a single GPS-based geodetic network in the US. The other existing sites remain in operation under support from non-NSF sources (e.g. the USGS), and EarthScope continues to benefit from their continued operation On the grounds of relevance to EarthScope science goals, geographic distribution and data quality, 209 of the 432 existing stations were selected as the nucleus upon which to build PBO. Conversion of these stations to a PBO-compatible mode of operation was begun under previous funding, and as a result data now flow directly to PBO archives and processing centers while maintenance, operations, and meta-data requirements are continue to be upgraded to PBO standards. At the end of this project all 209 stations have been fully incorporated into PBO, meeting all standards for new PBO construction including data communications and land use permits. Funds for operation of these stations have been included in approved budgets for PBO's Operations and Maintenance phase. The data from these stations serve a much larger audience than just the few people who work to keep them operating. This project is now collecting the data that will be used by the next generation of solid-earth researchers for at least two decades. Educational modules are being developed by a team of researchers, educators, and curriculum development professionals, and are being disseminated through regional and national workshops. An interactive website provides the newest developments in tectonics research to K-16 classrooms. class="ab'>
Optimal solution and optimality condition of the Hunter-Saxton equation
NASA Astrophysics Data System (ADS)
Shen, Chunyu
2018-02-01
This paper is devoted to the optimal distributed control problem governed by the Hunter-Saxton equation with constraints on the control. We first investigate the existence and uniqueness of weak solution for the controlled system with appropriate initial value and boundary conditions. In contrast with our previous research, the proof of solution mapping is local Lipschitz continuous, which is one big improvement. Second, based on the well-posedness result, we find a unique optimal control and optimal solution for the controlled system with the quadratic cost functional. Moreover, we establish the sufficient and necessary optimality condition of an optimal control by means of the optimal control theory, not limited to the necessary condition, which is another major novelty of this paper. We also discuss the optimality conditions corresponding to two physical meaningful distributed observation cases.
[Utility of atazanavir in special populations].
Antela López, Antonio
2008-12-01
ART (antiretroviral therapy) currently continues to indefinitely prolong the survival of patients who live with HIV. Due to this, we are increasingly faced with specific problems that previously did not have time to develop or did not have the importance that they have now, and which are related to the existence of special patient populations. Examples of situations that characterise these special populations are: co-infection with hepatitis virus B and/or C, pregnancy, lipodystrophy, cardiovascular risk, renal failure, treatment of children and adolescents, immigrant health care, and the management of patients receiving methadone replacement therapy, among others. In this article we review the role that Atazanavir (ATV) can play in the ART of patients in the situations mentioned, except those that are already dealt with specifically in other articles, such as co-infection by hepatitis virus B and/or C.
Stabilization for sampled-data neural-network-based control systems.
Zhu, Xun-Lin; Wang, Youyi
2011-02-01
This paper studies the problem of stabilization for sampled-data neural-network-based control systems with an optimal guaranteed cost. Unlike previous works, the resulting closed-loop system with variable uncertain sampling cannot simply be regarded as an ordinary continuous-time system with a fast-varying delay in the state. By defining a novel piecewise Lyapunov functional and using a convex combination technique, the characteristic of sampled-data systems is captured. A new delay-dependent stabilization criterion is established in terms of linear matrix inequalities such that the maximal sampling interval and the minimal guaranteed cost control performance can be obtained. It is shown that the newly proposed approach can lead to less conservative and less complex results than the existing ones. Application examples are given to illustrate the effectiveness and the benefits of the proposed method.
Plague dynamics are driven by climate variation.
Stenseth, Nils Chr; Samia, Noelle I; Viljugrein, Hildegunn; Kausrud, Kyrre Linné; Begon, Mike; Davis, Stephen; Leirs, Herwig; Dubyanskiy, V M; Esper, Jan; Ageyev, Vladimir S; Klassovskiy, Nikolay L; Pole, Sergey B; Chan, Kung-Sik
2006-08-29
The bacterium Yersinia pestis causes bubonic plague. In Central Asia, where human plague is still reported regularly, the bacterium is common in natural populations of great gerbils. By using field data from 1949-1995 and previously undescribed statistical techniques, we show that Y. pestis prevalence in gerbils increases with warmer springs and wetter summers: A 1 degrees C increase in spring is predicted to lead to a >50% increase in prevalence. Climatic conditions favoring plague apparently existed in this region at the onset of the Black Death as well as when the most recent plague pandemic arose in the same region, and they are expected to continue or become more favorable as a result of climate change. Threats of outbreaks may thus be increasing where humans live in close contact with rodents and fleas (or other wildlife) harboring endemic plague.
Relation of success and nontraditional career choice to selection for dating and friendship.
Kapoor, Usha; Pfost, Karen S; House, Alvin E; Pierson, Eric
2010-08-01
Women who succeed in traditionally male-dominated fields have previously been found to experience lower social acceptance, both from men in romantic contexts and from women in platonic contexts. The present study examined whether such preferences continue to exist. Participants were 256 university students (110 men, 146 women) with an average age of 21.4 yr. (SD = 3.6). They answered the Bem Sex Role Inventory and the Modern Sexism Scale and also responded to four descriptions of stimulus persons which represented the variables of traditional versus nontraditional field and successful versus nondescribed academic performance. Results indicated that men preferred to date women in traditional careers (independent of their success). This finding was unrelated to men's scores on sex role orientation or egalitarianism and sexism. However, in platonic relationships, women favored women in nontraditional careers as friends.
Implementation of Multipattern String Matching Accelerated with GPU for Intrusion Detection System
NASA Astrophysics Data System (ADS)
Nehemia, Rangga; Lim, Charles; Galinium, Maulahikmah; Rinaldi Widianto, Ahmad
2017-04-01
As Internet-related security threats continue to increase in terms of volume and sophistication, existing Intrusion Detection System is also being challenged to cope with the current Internet development. Multi Pattern String Matching algorithm accelerated with Graphical Processing Unit is being utilized to improve the packet scanning performance of the IDS. This paper implements a Multi Pattern String Matching algorithm, also called Parallel Failureless Aho Corasick accelerated with GPU to improve the performance of IDS. OpenCL library is used to allow the IDS to support various GPU, including popular GPU such as NVIDIA and AMD, used in our research. The experiment result shows that the application of Multi Pattern String Matching using GPU accelerated platform provides a speed up, by up to 141% in term of throughput compared to the previous research.
Review of even element super-heavy nuclei and search for element 120
Hofmann, S.; Heinz, S.; Mann, R.; ...
2016-06-28
The reaction 54Cr$ + $248Cm was investigated at the velocity filter SHIP at GSI, Darmstadt, with the intention to study production and decay properties of isotopes of element 120. Three correlated signals were measured, which occurred within a period of 279ms. The heights of the signals correspond with the expectations for a decay sequence starting with an isotope of element 120. However, a complete decay chain cannot be established, since a signal from the implantation of the evaporation residue cannot be identified unambiguously. Measured properties of the event chain are discussed in detail. The result is compared with theoretical predictions.more » Previously measured decay properties of even element super-heavy nuclei were compiled in order to find arguments for an assignment from the systematics of experimental data. In the course of this review, a few tentatively assigned data could be corrected. New interpretations are given for results which could not be assigned definitely in previous studies. The discussion revealed that the cross-section for production of element 120 could be high enough so that a successful experiment seems possible with presently available techniques. However, a continuation of the experiment at SHIP for a necessary confirmation of the results obtained in a relatively short irradiation of five weeks is not possible at GSI presently. Furthermore, we decided to publish the results of the measurement and of the review as they exist now. In the summary and outlook section we also present concepts for the continuation of research in the field of super-heavy nuclei.« less
The relational luring effect: Retrieval of relational information during associative recognition.
Popov, Vencislav; Hristova, Penka; Anders, Royce
2017-05-01
Here we argue that semantic relations (e.g., works in: nurse-hospital) have abstract independent representations in long-term memory (LTM) and that the same representation is accessed by all exemplars of a specific relation. We present evidence from 2 associative recognition experiments that uncovered a novel relational luring effect (RLE) in recognition memory. Participants studied word pairs, and then discriminated between intact (old) pairs and recombined lures. In the first experiment participants responded more slowly to lures that were relationally similar (table-cloth) to studied pairs (floor-carpet), in contrast to relationally dissimilar lures (pipe-water). Experiment 2 extended the RLE by showing a continuous effect of relational lure strength on recognition times (RTs), false alarms, and hits. It used a continuous pair recognition task, where each recombined lure or target could be preceded by 0, 1, 2, 3 or 4 different exemplars of the same relation. RTs and false alarms increased linearly with the number of different previously seen relationally similar pairs. Moreover, more typical exemplars of a given relation lead to a stronger RLE. Finally, hits for intact pairs also rose with the number of previously studied different relational instances. These results suggest that semantic relations exist as independent representations in LTM and that during associative recognition these representations can be a spurious source of familiarity. We discuss the implications of the RLE for current models of semantic and episodic memory, unitization in associative recognition, analogical reasoning and retrieval, as well as constructive memory research. (PsycINFO Database Record (c) 2017 APA, all rights reserved).
A controlled investigation of continuing pain education for long-term care staff.
Ghandehari, Omeed O; Hadjistavropoulos, Thomas; Williams, Jaime; Thorpe, Lilian; Alfano, Dennis P; Dal Bello-Haas, Vanina; Malloy, David C; Martin, Ronald R; Rahaman, Omar; Zwakhalen, Sandra M G; Carleton, R N; Hunter, Paulette V; Lix, Lisa M
2013-01-01
The underassessment and undertreatment of pain in residents of long-term care (LTC) facilities has been well documented. Gaps in staff knowledge and inaccurate beliefs have been identified as contributors. To investigate the effectiveness of an expert-based continuing education program in pain assessment⁄management for LTC staff. Participants included 131 LTC staff members who were randomly assigned to either an interactive pain education (PE) program, which addressed gaps in knowledge such as medication management, or an interactive control program consisting of general dementia education without a specific clinical focus. Participants attended three sessions, each lasting 3 h, and completed measures of pain-related knowledge and attitudes⁄beliefs before, immediately after and two weeks following the program. Focus groups were conducted with a subset of participants to gauge perception of the training program and barriers to implementing pain-related strategies. Analysis using ANOVA revealed that PE participants demonstrated larger gains compared with control participants with regard to pain knowledge and pain beliefs. Barriers to implementing pain-related strategies certainly exist. Nonetheless, qualitative analyses demonstrated that PE participants reported that they overcame many of these barriers and used pain management strategies four times more frequently than control participants. Contrary to previous research, the present study found that the interactive PE program was effective in changing pain beliefs and improving knowledge. Continuing PE in LTC has the potential to address knowledge gaps among front-line LTC providers.
2012-04-01
Progress in the pharmaceutical sector accounted for only a tiny proportion of the hundred or so new products and indications analysed by Prescrire in 2011. About 1 in 6 new products had more harms than benefits, while more than half of all new products provided no advantages over existing options. One worrisome trend was the expansion of "umbrella" ranges for self-medication. As in previous years, drug regulatory agencies continued to grant marketing authorisation prematurely or on the basis of inadequate evaluation. This was especially true for paediatric medicines, despite some limited progress. In the wake of the Mediator disaster, the French health authorities in charge of patient protection, including the drug regulatory agency, finally reacted by withdrawing many old drugs with negative harm-benefit balances and made an effort to increase transparency and to provide better information on drug-related harms. European authorities showed no signs of similar improvements in early 2012. Drug companies continue to promote their products aggressively, which is not in patients' best interests. The medicalisation of life continues apace, with more and more direct-to-consumer advertising. The Mediator disaster was a wake-up call for French policy makers. In late 2011, several new regulations serving patients' interests were adopted, including greater transparency and better management of conflicts of interest, but as yet, with no major breakthrough in attitudes and procedures.
On-line training of recurrent neural networks with continuous topology adaptation.
Obradovic, D
1996-01-01
This paper presents an online procedure for training dynamic neural networks with input-output recurrences whose topology is continuously adjusted to the complexity of the target system dynamics. This is accomplished by changing the number of the elements of the network hidden layer whenever the existing topology cannot capture the dynamics presented by the new data. The training mechanism is based on the suitably altered extended Kalman filter (EKF) algorithm which is simultaneously used for the network parameter adjustment and for its state estimation. The network consists of a single hidden layer with Gaussian radial basis functions (GRBF), and a linear output layer. The choice of the GRBF is induced by the requirements of the online learning. The latter implies the network architecture which permits only local influence of the new data point in order not to forget the previously learned dynamics. The continuous topology adaptation is implemented in our algorithm to avoid memory and computational problems of using a regular grid of GRBF'S which covers the network input space. Furthermore, we show that the resulting parameter increase can be handled "smoothly" without interfering with the already acquired information. If the target system dynamics are changing over time, we show that a suitable forgetting factor can be used to "unlearn" the no longer-relevant dynamics. The quality of the recurrent network training algorithm is demonstrated on the identification of nonlinear dynamic systems.
A participatory sensing approach to characterize ride quality
NASA Astrophysics Data System (ADS)
Bridgelall, Raj
2014-03-01
Rough roads increase vehicle operation and road maintenance costs. Consequently, transportation agencies spend a significant portion of their budgets on ride-quality characterization to forecast maintenance needs. The ubiquity of smartphones and social media, and the emergence of a connected vehicle environment present lucrative opportunities for cost-reduction and continuous, network-wide, ride-quality characterization. However, there is a lack of models to transform inertial and position information from voluminous data flows into indices that transportation agencies currently use. This work expands on theories of the Road Impact Factor introduced in previous research. The index characterizes road roughness by aggregating connected vehicle data and reporting roughness in direct proportion to the International Roughness Index. Their theoretical relationships are developed, and a case study is presented to compare the relative data quality from an inertial profiler and a regular passenger vehicle. Results demonstrate that the approach is a viable alternative to existing models that require substantially more resources and provide less network coverage. One significant benefit of the participatory sensing approach is that transportation agencies can monitor all network facilities continuously to locate distress symptoms, such as frost heaves, that appear and disappear between ride assessment cycles. Another benefit of the approach is continuous monitoring of all high-risk intersections such as rail grade crossings to better understand the relationship between ride-quality and traffic safety.
River-induced flow dynamics in long-screen wells and impact on aqueous samples.
Vermeul, Vince R; McKinley, James P; Newcomer, Darrell R; Mackley, Robert D; Zachara, J M
2011-01-01
Previously published field investigations and modeling studies have demonstrated the potential for sample bias associated with vertical wellbore flow in conventional monitoring wells constructed with long-screened intervals. This article builds on the existing body of literature by (1) demonstrating the utility of continuous (i.e., hourly measurements for ∼1 month) ambient wellbore flow monitoring and (2) presenting results from a field experiment where relatively large wellbore flows (up to 4 L/min) were induced by aquifer hydrodynamics associated with a fluctuating river boundary located approximately 250 m from the test well. The observed vertical wellbore flows were strongly correlated with fluctuations in river stage, alternating between upward and downward flow throughout the monitoring period in response to changes in river stage. Continuous monitoring of ambient wellbore flows using an electromagnetic borehole flowmeter allowed these effects to be evaluated in concert with continuously monitored river-stage elevations (hourly) and aqueous uranium concentrations (daily) in a long-screen well and an adjacent multilevel well cluster. This study demonstrates that when contaminant concentrations within the aquifer vary significantly over the depth interval interrogated, river-induced vertical wellbore flow can result in variations in measured concentration that nearly encompass the full range of variation in aquifer contaminant concentration with depth. Copyright © 2010 Battelle Memorial Institute. Journal compilation © 2010 National Ground Water Association.
45 CFR 2301.150 - Program accessibility: Existing facilities.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 45 Public Welfare 4 2010-10-01 2010-10-01 false Program accessibility: Existing facilities. 2301.150 Section 2301.150 Public Welfare Regulations Relating to Public Welfare (Continued) ARCTIC RESEARCH... THE UNITED STATES ARCTIC RESEARCH COMMISSION § 2301.150 Program accessibility: Existing facilities. (a...
45 CFR 2301.150 - Program accessibility: Existing facilities.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 45 Public Welfare 4 2011-10-01 2011-10-01 false Program accessibility: Existing facilities. 2301.150 Section 2301.150 Public Welfare Regulations Relating to Public Welfare (Continued) ARCTIC RESEARCH... THE UNITED STATES ARCTIC RESEARCH COMMISSION § 2301.150 Program accessibility: Existing facilities. (a...
40 CFR 415.474 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 30 2012-07-01 2012-07-01 false Pretreatment standards for existing... (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS INORGANIC CHEMICALS MANUFACTURING POINT SOURCE CATEGORY Nickel Salts Production Subcategory § 415.474 Pretreatment standards for existing sources (PSES). (a) Except as...
40 CFR 415.364 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 30 2013-07-01 2012-07-01 true Pretreatment standards for existing... (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS INORGANIC CHEMICALS MANUFACTURING POINT SOURCE CATEGORY Copper Salts Production Subcategory § 415.364 Pretreatment standards for existing sources (PSES). (a) Except as...
40 CFR 415.474 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 28 2010-07-01 2010-07-01 true Pretreatment standards for existing... (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS INORGANIC CHEMICALS MANUFACTURING POINT SOURCE CATEGORY Nickel Salts Production Subcategory § 415.474 Pretreatment standards for existing sources (PSES). (a) Except as...
40 CFR 415.644 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 30 2013-07-01 2012-07-01 true Pretreatment standards for existing... (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS INORGANIC CHEMICALS MANUFACTURING POINT SOURCE CATEGORY Cadmium Pigments and Salts Production Subcategory § 415.644 Pretreatment standards for existing sources (PSES). (a...
40 CFR 415.474 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 29 2014-07-01 2012-07-01 true Pretreatment standards for existing... (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS INORGANIC CHEMICALS MANUFACTURING POINT SOURCE CATEGORY Nickel Salts Production Subcategory § 415.474 Pretreatment standards for existing sources (PSES). (a) Except as...
40 CFR 415.644 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 28 2010-07-01 2010-07-01 true Pretreatment standards for existing... (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS INORGANIC CHEMICALS MANUFACTURING POINT SOURCE CATEGORY Cadmium Pigments and Salts Production Subcategory § 415.644 Pretreatment standards for existing sources (PSES). (a...
40 CFR 430.46 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Pretreatment standards for existing...) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) THE PULP, PAPER, AND PAPERBOARD POINT SOURCE CATEGORY Dissolving Sulfite Subcategory § 430.46 Pretreatment standards for existing sources (PSES). Except as...
40 CFR 415.644 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 30 2012-07-01 2012-07-01 false Pretreatment standards for existing... (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS INORGANIC CHEMICALS MANUFACTURING POINT SOURCE CATEGORY Cadmium Pigments and Salts Production Subcategory § 415.644 Pretreatment standards for existing sources (PSES). (a...
40 CFR 430.46 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Pretreatment standards for existing...) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) THE PULP, PAPER, AND PAPERBOARD POINT SOURCE CATEGORY Dissolving Sulfite Subcategory § 430.46 Pretreatment standards for existing sources (PSES). Except as...
40 CFR 415.644 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 29 2014-07-01 2012-07-01 true Pretreatment standards for existing... (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS INORGANIC CHEMICALS MANUFACTURING POINT SOURCE CATEGORY Cadmium Pigments and Salts Production Subcategory § 415.644 Pretreatment standards for existing sources (PSES). (a...
40 CFR 429.95 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Pretreatment standards for existing...) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) TIMBER PRODUCTS PROCESSING POINT SOURCE CATEGORY Wood Preserving-Boulton Subcategory § 429.95 Pretreatment standards for existing sources (PSES). Except as...
40 CFR 415.654 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 30 2013-07-01 2012-07-01 true Pretreatment standards for existing... (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS INORGANIC CHEMICALS MANUFACTURING POINT SOURCE CATEGORY Cobalt Salts Production Subcategory § 415.654 Pretreatment standards for existing sources (PSES). Except as...
40 CFR 429.85 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Pretreatment standards for existing...) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) TIMBER PRODUCTS PROCESSING POINT SOURCE CATEGORY Wood Preserving Steam Subcategory § 429.85 Pretreatment standards for existing sources (PSES). Except as provided...
40 CFR 415.474 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 30 2013-07-01 2012-07-01 true Pretreatment standards for existing... (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS INORGANIC CHEMICALS MANUFACTURING POINT SOURCE CATEGORY Nickel Salts Production Subcategory § 415.474 Pretreatment standards for existing sources (PSES). (a) Except as...
Validation of the GOES-16 magnetometer using multipoint measurements and magnetic field models
NASA Astrophysics Data System (ADS)
Califf, S.; Loto'aniu, P. T. M.; Redmon, R. J.; Sarris, T. E.; Brito, T.
2017-12-01
The Geostationary Operational Environmental Satellites (GOES) have been providing continuous geomagnetic field measurements for over 40 years. While the primary purpose of GOES is operational, the magnetometer data are also widely used in the scientific community. In an effort to validate the recently launched GOES-16 magnetometer, we compare the measurements to existing magnetic field models and other GOES spacecraft currently on orbit. There are four concurrent measurements from GOES-13, 14, 15 and 16 spanning 75W to 135W longitude. Also, GOES-13 is being replaced by GOES-16 in the GOES-East location, and during the transition, GOES-13 and GOES-16 will be parked nearby in order to assist with calibration of the new operational satellite. This work explores techniques to quantify the performance of the GOES-16 magnetometer by comparison to data from nearby spacecraft. We also build on previous work to assimilate in situ measurements with existing magnetic field models to assist in comparing data from different spatial locations. Finally, we use this unique dataset from four simultaneous geosynchronous magnetometer measurements and the close separation between GOES-13 and GOES-16 to study the spatial characteristics of ULF waves and other magnetospheric processes.
Wheeling and stranded investment-is there a better way
DOE Office of Scientific and Technical Information (OSTI.GOV)
Ferrar, T.
Under current franchise law, retail wheeling must be addressed on a state-by-state basis, and (therefore) it will not sweep the electric power industry as deregulation has been visited upon the telecommunications, airline, natural gas and other industries. Nevertheless, many industry observers remain concerned that retail competition will create a significant stranded investment problem. That is, broadened competition among power generators for customers will result in the market value of some existing (previously market-protected) generation assets falling below book value. The significance of such asset revaluations, and the time required for adjustment, increases with the capital intensity of the industry; thismore » is the reason for the heightened concern regarding the introduction of retail wheeling into the electric power industry. One policy direction that may be worthy of further debate and losses during the power market's transition to a more competitive equilibrium - i.e., until regulation-induced differentials between market and book values are mitigated. A two-part policy proposal is offered for consideration. First, the use of intra-pool transfer payments; second, if stranded investment continues to exist, a temporary uniform pool-wide wheeling surcharge.« less
NASA Technical Reports Server (NTRS)
Buckey, J. C. Jr; Musiek, F. E.; Kline-Schoder, R.; Clark, J. C.; Hart, S.; Havelka, J.
2001-01-01
BACKGROUND: Temporary and, in some cases, permanent hearing loss has been documented after long-duration spaceflights. METHODS: We examined all existing published data on hearing loss after space missions to characterize the losses. RESULTS: Data from Russian missions suggest that the hearing loss, when it occurs, affects mainly mid to high frequencies and that using hearing protection often might prevent the loss. Several significant questions remain about hearing loss in space. While the hearing loss has been presumed to be noise-induced, no clear link has been established between noise exposure and hearing loss during spaceflight. In one documented case of temporary hearing loss from the Shuttle-Mir program, the pattern of loss was atypical for a noise-induced loss. Continuous noise levels that have been measured on the Mir and previous space stations, while above engineering standards, are not at levels usually associated with hearing loss in ground-based studies (which have usually been limited to 8-10 h exposure periods). Attempts to measure hearing in space using threshold-based audiograms have been unsuccessful in both the American and Russian programs due to noise interference with the measurements. CONCLUSIONS: The existing data highlight the need for reliable monitoring of both hearing and noise in long-duration spaceflight.
Tonmukayakul, Utsana; Sia, Kah-Ling; Gold, Lisa; Hegde, Shalika; de Silva, Andrea M; Moodie, Marj
2015-01-01
To identify economic evaluation models and parameters that could be replicated or adapted to construct a generic model to assess cost-effectiveness of and prioritise a wide range of community-based oral disease prevention programmes in an Australian context. The literature search was conducted using MEDLINE, ERIC, PsycINFO, CINHAL (EBSCOhost), EMBASE (Ovid), CRD, DARE, NHSEED, HTA, all databases in the Cochrane library, Scopus and ScienceDirect databases from their inception to November 2012. Thirty-three articles met the criteria for inclusion in this review (7 were Australian studies, 26 articles were international). Existing models focused primarily on dental caries. Periodontal disease, another common oral health problem, was lacking. Among caries prevention studies, there was an absence of clear evidence showing continuous benefits from primary through to permanent dentition and the long-term effects of oral health promotion. No generic model was identified from previous studies that could be immediately adopted or adapted for our purposes of simulating and prioritising a diverse range of oral health interventions for Australian children and adolescents. Nevertheless, data sources specified in the existing Australian-based models will be useful for developing a generic model for such purposes.
Evidences on the Existence of Magnetic Flux Rope Before and During a Solar Eruption
NASA Astrophysics Data System (ADS)
Zhang, Jie; Cheng, Xin; Liu, Kai
2013-03-01
We report the observational evidences from the advanced SDO observations that magnetic flux ropes exist before and during solar eruptions. The solar eruption is defined as coronal mass ejection, whether or not associated with a solar flare. Magnetic flux ropes are directly observed as hot EUV channels as seen in the hot AIA 131 (10 MK) and/or AIA 94 (6.4 MK) passbands, but are absent in cool AIA passbands. The fact that flux ropes are only seen in hot temperatures explains their evasion of detection from previous EUV observations, such as SOHO/EIT, TRACE and STEREO/EUVI. The hot channel usually appears as a writhed sigmoidal shape and slowly rises prior to the onset of the impulsive acceleration as well as the onset of the flare. The hot channel transforms into a CME-like semi-circular shape in a continuous way, indicating its trapping or organization by a coherent magnetic structure. The dynamic and thermal properties of flux ropes will also be presented. We further discuss the critical role of flux ropes in CME initiation and subsequent acceleration, in light of contrasting the standard eruptive flare models.
Open-source software platform for medical image segmentation applications
NASA Astrophysics Data System (ADS)
Namías, R.; D'Amato, J. P.; del Fresno, M.
2017-11-01
Segmenting 2D and 3D images is a crucial and challenging problem in medical image analysis. Although several image segmentation algorithms have been proposed for different applications, no universal method currently exists. Moreover, their use is usually limited when detection of complex and multiple adjacent objects of interest is needed. In addition, the continually increasing volumes of medical imaging scans require more efficient segmentation software design and highly usable applications. In this context, we present an extension of our previous segmentation framework which allows the combination of existing explicit deformable models in an efficient and transparent way, handling simultaneously different segmentation strategies and interacting with a graphic user interface (GUI). We present the object-oriented design and the general architecture which consist of two layers: the GUI at the top layer, and the processing core filters at the bottom layer. We apply the framework for segmenting different real-case medical image scenarios on public available datasets including bladder and prostate segmentation from 2D MRI, and heart segmentation in 3D CT. Our experiments on these concrete problems show that this framework facilitates complex and multi-object segmentation goals while providing a fast prototyping open-source segmentation tool.
Killingback, Timothy; Doebeli, Michael
2002-10-01
Understanding the evolutionary origin and persistence of cooperative behavior is a fundamental biological problem. The standard "prisoner's dilemma," which is the most widely adopted framework for studying the evolution of cooperation through reciprocal altruism between unrelated individuals, does not allow for varying degrees of cooperation. Here we study the continuous iterated prisoner's dilemma, in which cooperative investments can vary continuously in each round. This game has been previously considered for a class of reactive strategies in which current investments are based on the partner's previous investment. In the standard iterated prisoner's dilemma, such strategies are inferior to strategies that take into account both players' previous moves, as is exemplified by the evolutionary dominance of "Pavlov" over "tit for tat." Consequently, we extend the analysis of the continuous prisoner's dilemma to a class of strategies in which current investments depend on previous payoffs and, hence, on both players' previous investments. We show, both analytically and by simulation, that payoff-based strategies, which embody the intuitively appealing idea that individuals invest more in cooperative interactions when they profit from these interactions, provide a natural explanation for the gradual evolution of cooperation from an initially noncooperative state and for the maintenance of cooperation thereafter.
NASA Astrophysics Data System (ADS)
Chan, Kennedy Kam Ho; Yung, Benny Hin Wai
2017-03-01
Teaching experience has been identified as an important factor in pedagogical content knowledge (PCK) development. However, little is known about how experienced teachers may draw on their previous experience to facilitate their PCK development. This study examined how two experienced high school biology teachers approached the teaching of a newly introduced topic in the curriculum, polymerase chain reaction and their PCK development from the pre-lesson planning phase through the interactive phase to the post-lesson reflection phase. Multiple data sources included classroom observations, field notes, semi-structured interviews and classroom artefacts. It was found that the teachers' previous experience informed their planning for teaching the new topic, but in qualitatively different ways. This, in turn, had a bearing on their new PCK development. Subject matter knowledge (SMK) can not only facilitate but may also hinder this development. Our findings identify two types of experienced teachers: those who can capitalise on their previous teaching experiences and SMK to develop new PCK and those who do not. The critical difference is whether in the lesson planning stage, the teacher shows the disposition to draw on a generalised mental framework that enables the teacher to capitalise on his existing SMK to develop new PCK. Helping teachers to acquire this disposition should be a focus for teacher training in light of continuous curriculum changes.
Association of volume of patient encounters with residents' in-training examination performance.
McCoy, Christopher P; Stenerson, Matthew B; Halvorsen, Andrew J; Homme, Jason H; McDonald, Furman S
2013-08-01
Patient care and medical knowledge are Accreditation Council for Graduate Medical Education (ACGME) core competencies. The correlation between amount of patient contact and knowledge acquisition is not known. To determine if a correlation exists between the number of patient encounters and in-training exam (ITE) scores in internal medicine (IM) and pediatric residents at a large academic medical center. Retrospective cohort study Resident physicians at Mayo Clinic from July 2006 to June 2010 in IM (318 resident-years) and pediatrics (66 resident-years). We tabulated patient encounters through review of clinical notes in an electronic medical record during post graduate year (PGY)-1 and PGY-2. Using linear regression models, we investigated associations between ITE score and number of notes during the previous PGY, adjusted for previous ITE score, gender, medical school origin, and conference attendance. For IM, PGY-2 admission and consult encounters in the hospital and specialty clinics had a positive linear association with ITE-3 % score (β = 0.02; p = 0.004). For IM, PGY-1 conference attendance is positively associated with PGY-2 ITE performance. We did not detect a correlation between PGY-1 patient encounters and subsequent ITE scores for IM or pediatric residents. No association was found between IM PGY-2 ITE score and inpatient, outpatient, or total encounters in the first year of training. Resident continuity clinic and total encounters were not associated with change in PGY-3 ITE score. We identified a positive association between hospital and subspecialty encounters during the second year of IM training and subsequent ITE score, such that each additional 50 encounters were associated with an increase of 1 % correct in PGY-3 ITE score after controlling for previous ITE performance and continuity clinic encounters. We did not find a correlation for volume of encounters and medical knowledge for IM PGY-1 residents or the pediatric cohort.
Infinite time interval backward stochastic differential equations with continuous coefficients.
Zong, Zhaojun; Hu, Feng
2016-01-01
In this paper, we study the existence theorem for [Formula: see text] [Formula: see text] solutions to a class of 1-dimensional infinite time interval backward stochastic differential equations (BSDEs) under the conditions that the coefficients are continuous and have linear growths. We also obtain the existence of a minimal solution. Furthermore, we study the existence and uniqueness theorem for [Formula: see text] [Formula: see text] solutions of infinite time interval BSDEs with non-uniformly Lipschitz coefficients. It should be pointed out that the assumptions of this result is weaker than that of Theorem 3.1 in Zong (Turkish J Math 37:704-718, 2013).
31 CFR 306.127 - Preservation of existing rights.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Preservation of existing rights. 306.127 Section 306.127 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued.... SECURITIES Miscellaneous Provisions § 306.127 Preservation of existing rights. Nothing contained in these...
40 CFR 467.45 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2010 CFR
2010-07-01
... sources. 467.45 Section 467.45 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS ALUMINUM FORMING POINT SOURCE CATEGORY Forging Subcategory § 467.45 Pretreatment standards for existing sources. Except as provided in 40 CFR 403.7 and 403.13, any existing source...
40 CFR 467.35 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2010 CFR
2010-07-01
... sources. 467.35 Section 467.35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS ALUMINUM FORMING POINT SOURCE CATEGORY Extrusion Subcategory § 467.35 Pretreatment standards for existing sources. (a) Except as provided in 40 CFR 403.7 and 403.13, any existing...
40 CFR 430.96 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Pretreatment standards for existing...) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) THE PULP, PAPER, AND PAPERBOARD POINT SOURCE CATEGORY Secondary Fiber Deink Subcategory § 430.96 Pretreatment standards for existing sources (PSES). (a) Except as...
40 CFR 430.36 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Pretreatment standards for existing...) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) THE PULP, PAPER, AND PAPERBOARD POINT SOURCE CATEGORY Unbleached Kraft Subcategory § 430.36 Pretreatment standards for existing sources (PSES). Except as provided...
40 CFR 430.36 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Pretreatment standards for existing...) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) THE PULP, PAPER, AND PAPERBOARD POINT SOURCE CATEGORY Unbleached Kraft Subcategory § 430.36 Pretreatment standards for existing sources (PSES). Except as provided...
40 CFR 430.76 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Pretreatment standards for existing...) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) THE PULP, PAPER, AND PAPERBOARD POINT SOURCE CATEGORY Mechanical Pulp Subcategory § 430.76 Pretreatment standards for existing sources (PSES). (a) The following...
40 CFR 455.26 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Pretreatment standards for existing...) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) PESTICIDE CHEMICALS Organic Pesticide Chemicals Manufacturing Subcategory § 455.26 Pretreatment standards for existing sources (PSES). Except as provided in 40 CFR 403.7...
40 CFR 430.16 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Pretreatment standards for existing...) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) THE PULP, PAPER, AND PAPERBOARD POINT SOURCE CATEGORY Dissolving Kraft Subcategory § 430.16 Pretreatment standards for existing sources (PSES). Except as provided...
40 CFR 430.96 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Pretreatment standards for existing...) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) THE PULP, PAPER, AND PAPERBOARD POINT SOURCE CATEGORY Secondary Fiber Deink Subcategory § 430.96 Pretreatment standards for existing sources (PSES). (a) Except as...
Analysis of continuous-time switching networks
NASA Astrophysics Data System (ADS)
Edwards, R.
2000-11-01
Models of a number of biological systems, including gene regulation and neural networks, can be formulated as switching networks, in which the interactions between the variables depend strongly on thresholds. An idealized class of such networks in which the switching takes the form of Heaviside step functions but variables still change continuously in time has been proposed as a useful simplification to gain analytic insight. These networks, called here Glass networks after their originator, are simple enough mathematically to allow significant analysis without restricting the range of dynamics found in analogous smooth systems. A number of results have been obtained before, particularly regarding existence and stability of periodic orbits in such networks, but important cases were not considered. Here we present a coherent method of analysis that summarizes previous work and fills in some of the gaps as well as including some new results. Furthermore, we apply this analysis to a number of examples, including surprising long and complex limit cycles involving sequences of hundreds of threshold transitions. Finally, we show how the above methods can be extended to investigate aperiodic behaviour in specific networks, though a complete analysis will have to await new results in matrix theory and symbolic dynamics.
Analytical Results from Routine DSSHT and SEHT Monthly Samples
DOE Office of Scientific and Technical Information (OSTI.GOV)
Peters, T. B.
2016-08-17
Strip Effluent Hold Tank (SEHT) and Decontaminated Salt Solution Hold Tank (DSSHT) samples from several of the “microbatches” of Integrated Salt Disposition Project (ISDP) Salt Batch (“Macrobatch”) 8B have been analyzed for 238Pu, 90Sr, 137Cs, cations (Inductively Coupled Plasma Emission Spectroscopy - ICPES), and anions (Ion Chromatography Anions - IC-A). The analytical results from the current microbatch samples are similar to those from previous macrobatch samples. The Actinide Removal Process (ARP) and the Modular Caustic-Side Solvent Extraction Unit (MCU) continue to show more than adequate Pu and Sr removal for times when monosodium titanate (MST) is used. Even with nomore » MST strike being performed there exists some small Pu and Sr removal, likely from filtration of fines containing these elements. The Cs removal continues to be excellent, with decontamination factors (DF) averaging 16,400. The bulk chemistry of the DSSHT and SEHT samples do not show any signs of unusual behavior. SRNL recommends that a sample of the strip feed be analyzed for cation and anion content if a further decline in boron concentration is noted in future SEHT samples.« less
Klueh, Ulrike; Czajkowski, Caroline; Ludzinska, Izabela; Qiao, Yi; Frailey, Jackman; Kreutzer, Donald L.
2016-01-01
The accumulation of macrophages (MΦ) at the sensor-tissue interface is thought to be a major player in controlling tissue reactions and sensor performance in vivo. Nevertheless until recently no direct demonstration of the causal relationship between MΦ aggregation and loss of sensor function existed. Using a Continuous Glucose Monitoring (CGM) murine model we previously demonstrated that genetic deficiencies of MΦ or depletion of MΦ decreased MΦ accumulation at sensor implantation sites, which led to significantly enhanced CGM performance, when compared to normal mice. Additional studies in our laboratories have also demonstrated that MΦ can act as “metabolic sinks” by depleting glucose levels at the implanted sensors in vitro and in vivo. In the present study we extended these observations by demonstrating that MΦ chemokine (CCL2) and receptor (CCR2) knockout mice displayed a decrease in inflammation and MΦ recruitment at sensor implantation sites, when compared to normal mice. This decreased MΦ recruitment significantly enhanced CGM performance when compared to control mice. These studies demonstrated the importance of the CCL2 family of chemokines and related receptors in MΦ recruitment and sensor performance and suggest chemokine targets for enhancing CGM in vivo. PMID:27376197
Overview of surgical scar prevention and management.
Son, Daegu; Harijan, Aram
2014-06-01
Management of incisional scar is intimately connected to stages of wound healing. The management of an elective surgery patient begins with a thorough informed consent process in which the patient is made aware of personal and clinical circumstances that cannot be modified, such as age, ethnicity, and previous history of hypertrophic scars. In scar prevention, the single most important modifiable factor is wound tension during the proliferative and remodeling phases, and this is determined by the choice of incision design. Traditional incisions most often follow relaxed skin tension lines, but no such lines exist in high surface tension areas. If such incisions are unavoidable, the patient must be informed of this ahead of time. The management of a surgical incision does not end when the sutures are removed. Surgical scar care should be continued for one year. Patient participation is paramount in obtaining the optimal outcome. Postoperative visits should screen for signs of scar hypertrophy and has a dual purpose of continued patient education and reinforcement of proper care. Early intervention is a key to control hyperplastic response. Hypertrophic scars that do not improve by 6 months are keloids and should be managed aggressively with intralesional steroid injections and alternate modalities.
An Account of Women's Progress in Engineering: a Social Cognitive Perspective
NASA Astrophysics Data System (ADS)
Vogt, Christina
Traditionally, women were not welcome in higher education, especially in male-dominated fields. Undoubtedly, women have dramatically increased their enrollments in many once male-only fields, such as law, medicine, and several of the sciences; nevertheless, engineering remains a field where women continue to be underrepresented. This has often been attributed to social barriers in engineering classrooms. However, a new turn of events has been reported: Young women entering engineering may receive higher grades and have a greater tendency to remain than men. To examine what has recently changed, the author applied Bandura's triadic model of reciprocity between environment, self, and behavior. The measured variables included academic integration or discrimination, self-measures of academic self-confidence, engineering self-efficacy, and behaviors taken to self-regulate learning: critical thinking, effort, peer learning, and help seeking. The data revealed that women apply slightly more effort and have slightly less self-efficacy than men. Their academic confidence is nearly equal in almost all areas. Most significantly, many previous gender biases appear diminished, and those that do exist are slight. However, it is recommended that continued efforts be undertaken to attract and retain women in engineering programs.
Autobiographical memory functions in young Japanese men and women.
Maki, Yoichi; Kawasaki, Yayoi; Demiray, Burcu; Janssen, Steve M J
2015-01-01
The present study examined whether the three major functions of autobiographical memory observed in Western societies (i.e., directing-behaviour, social-bonding and self-continuity) also exist in an East Asian society. Two self-report measures were used to assess the autobiographical memory functions of Japanese men and women. Japanese young adults (N = 451, ages 17-28 years) first completed the original Thinking About Life Experiences (TALE) Questionnaire. They subsequently received three TALE items that represented memory functions and attempted to recall a specific instance of memory recall for each item. Confirmatory factor analyses on the TALE showed that the three functions were replicated in the current sample. However, Japanese participants reported lower levels of all three functions than American participants in a previous study. We also explored whether there was an effect of gender in this Japanese sample. Women reported higher levels of the self-continuity and social-bonding functions than men. Finally, participants recalled more specific instances of memory recall for the TALE items that had received higher ratings on the TALE, suggesting that the findings on the first measure were supported by the second measure. Results are discussed in relation to the functional approach to autobiographical memory in a cross-cultural context.
The presence of field geologists in Mars-like terrain
NASA Technical Reports Server (NTRS)
Mcgreevy, Michael W.
1992-01-01
Methods of ethnographic observation and analysis have been coupled with object-oriented analysis and design concepts to begin the development of a clear path from observations in the field to the design of virtual presence systems. The existence of redundancies in field geology and presence allowed for the application of methods for understanding complex systems. As a result of this study, some of these redundancies have been characterized. Those described are all classes of continuity relations, including the continuities of continuous existence, context-constituent continuities, and state-process continuities. The discussion of each includes statements of general relationships, logical consequences of these, and hypothetical situations in which the relationships would apply. These are meant to aid in the development of a theory of presence. The discussion also includes design considerations, providing guidance for the design of virtual planetary exploration systems and other virtual presence systems. Converging evidence regarding continuity in presence is found in the nature of psychological dissociation. Specific methodological refinements should enhance ecological validity in subsequent field studies, which are in progress.
The Cauchy Problem in Local Spaces for the Complex Ginzburg-Landau EquationII. Contraction Methods
NASA Astrophysics Data System (ADS)
Ginibre, J.; Velo, G.
We continue the study of the initial value problem for the complex Ginzburg-Landau equation
Fear of childbirth: mothers' experiences of team-midwifery care - a follow-up study.
Lyberg, Anne; Severinsson, Elisabeth
2010-05-01
The aim of this study was to illuminate mothers' fear of childbirth and their experiences of the team-midwifery care model during pregnancy, childbirth and the postnatal period. Maternal anxiety and fear of childbirth lead to emotional suffering and affected women's well-being. A previous negative experience of childbirth may result in postnatal depression or avoidance of future pregnancies. This hermeneutic study comprised interviews with 13 women, which were audio-taped and transcribed verbatim, after which interpretative content analysis was performed. Ethical approval was granted. The findings revealed one main theme: The woman's right to ownership of the pregnancy, childbirth and postnatal care as a means of maintaining dignity and three themes; Being aware of barriers and reasons for fear; Being prepared for childbirth and Being confirmed and treated with dignity by the midwife. Each theme contained several sub-themes. The findings contribute insights into how midwives can be educated to reduce fear of childbirth and promote positive birth experiences, despite the existence of negative memories of previous births. In order to achieve continuity and a trusting relationship it is necessary to organise leadership and to adopt models that are flexible and support women's health.
ERIC Educational Resources Information Center
Lamoureux, Marvin E.
The objective of the study conducted at the Centre for Continuing Education (CCE) at the University of British Columbia was to determine that threshold pricing not only existed for continuing education courses, but also was applicable to an administrative decision-making structure. The first part of the three-part investigation analyzed consumer…
Well-posedness and continuity properties of the Fornberg-Whitham equation in Besov spaces
NASA Astrophysics Data System (ADS)
Holmes, John; Thompson, Ryan C.
2017-10-01
In this paper, we prove well-posedness of the Fornberg-Whitham equation in Besov spaces B2,rs in both the periodic and non-periodic cases. This will imply the existence and uniqueness of solutions in the aforementioned spaces along with the continuity of the data-to-solution map provided that the initial data belongs to B2,rs. We also establish sharpness of continuity on the data-to-solution map by showing that it is not uniformly continuous from any bounded subset of B2,rs to C ([ - T , T ] ;B2,rs). Furthermore, we prove a Cauchy-Kowalevski type theorem for this equation that establishes the existence and uniqueness of real analytic solutions and also provide blow-up criterion for solutions.
14 CFR 216.6 - Existing unauthorized operations.
Code of Federal Regulations, 2010 CFR
2010-01-01
... PROCEEDINGS) ECONOMIC REGULATIONS COMMINGLING OF BLIND SECTOR TRAFFIC BY FOREIGN AIR CARRIERS § 216.6 Existing... existing blind sector operations which have been regularly performed by such carrier commencing on a date prior to August 9, 1967, such carrier may continue to engage in such blind sector operations until final...
40 CFR 467.25 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2010 CFR
2010-07-01
... § 467.25 Pretreatment standards for existing sources. Except as provided in 40 CFR 403.7 and 403.13, any... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Pretreatment standards for existing sources. 467.25 Section 467.25 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED...
40 CFR 467.55 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2010 CFR
2010-07-01
... § 467.55 Pretreatment standards for existing sources. Except as provided in 40 CFR 403.7 and 403.13, any... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Pretreatment standards for existing sources. 467.55 Section 467.55 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED...
40 CFR 467.65 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2010 CFR
2010-07-01
... sources. 467.65 Section 467.65 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Subcategory § 467.65 Pretreatment standards for existing sources. Except as provided in 40 CFR 403.7 and 403.13, any existing source subject to this subpart which introduces pollutants into a publicly owned...
40 CFR 467.15 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2010 CFR
2010-07-01
... § 467.15 Pretreatment standards for existing sources. Except as provided in 40 CFR 403.7 and 403.13, any... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Pretreatment standards for existing sources. 467.15 Section 467.15 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED...
40 CFR 465.24 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Pretreatment standards for existing...) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) COIL COATING POINT SOURCE CATEGORY Galvanized Basis Material Subcategory § 465.24 Pretreatment standards for existing sources. Except as provided in 40 CFR 403.7 and 403...
40 CFR 465.34 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Pretreatment standards for existing...) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) COIL COATING POINT SOURCE CATEGORY Aluminum Basis Material Subcategory § 465.34 Pretreatment standards for existing sources. Except as provided in 40 CFR 403.7 and 403...
40 CFR 465.14 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Pretreatment standards for existing...) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) COIL COATING POINT SOURCE CATEGORY Steel Basis Material Subcategory § 465.14 Pretreatment standards for existing sources. Except as provided in 40 CFR 403.7 and 403...
40 CFR 430.66 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Pretreatment standards for existing...) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) THE PULP, PAPER, AND PAPERBOARD POINT SOURCE CATEGORY Semi-Chemical Subcategory § 430.66 Pretreatment standards for existing sources (PSES). Except as provided in 40...
40 CFR 432.74 - Pretreatment standards for existing sources (PSES). [Reserved
Code of Federal Regulations, 2010 CFR
2010-07-01
... (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS MEAT AND POULTRY PRODUCTS POINT SOURCE CATEGORY Sausage and Luncheon Meats Processors § 432.74 Pretreatment standards for existing sources (PSES). [Reserved] ...
40 CFR 432.74 - Pretreatment standards for existing sources (PSES). [Reserved
Code of Federal Regulations, 2011 CFR
2011-07-01
... (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS MEAT AND POULTRY PRODUCTS POINT SOURCE CATEGORY Sausage and Luncheon Meats Processors § 432.74 Pretreatment standards for existing sources (PSES). [Reserved] ...
Avionics Integrity Program (AVIP). Volume 4. Force Management - Economic Life Considerations.
1984-03-01
often used to refer to the period of time during which financial considerations justify the continued use of an existing system. The study addresses...rejporLs incl-ude contractor ei forts between September 1983 and Marih 1984. Each report represents a completed study in a specific area and stands alone...during which financial considerations justify the selection or continued use of a system. A variety of definitions currently exist for economic life. One
40 CFR 455.11 - Compliance date for pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2012 CFR
2012-07-01
... PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) PESTICIDE CHEMICALS Organic Pesticide Chemicals Manufacturing Subcategory § 455.11 Compliance date for pretreatment standards for...
40 CFR 455.11 - Compliance date for pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2014 CFR
2014-07-01
... PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) PESTICIDE CHEMICALS Organic Pesticide Chemicals Manufacturing Subcategory § 455.11 Compliance date for pretreatment standards for...
40 CFR 455.11 - Compliance date for pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2013 CFR
2013-07-01
... PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) PESTICIDE CHEMICALS Organic Pesticide Chemicals Manufacturing Subcategory § 455.11 Compliance date for pretreatment standards for...
NASA Astrophysics Data System (ADS)
Zhang, X.; Bianchi, T. S.; Cui, X.; Rosenheim, B. E.; Ping, C. L.; Kanevskiy, M. Z.; Hanna, A. M.; Allison, M. A.
2016-12-01
As temperatures in the Arctic rise abnormally fast, permafrost in the region is vulnerable to extensive thawing. This could release previously frozen organic carbon (OC) into the contemporary carbon cycle, giving a positive feedback on global warming. Recent research has found the presence of particulate permafrost in rivers, deltas, and continental shelves in the Arctic, but little direct evidence exists on the mechanism of transportation of previously frozen soils from watershed to the coast. The Colville River in northern Alaska is the largest North American Arctic River with a continuous permafrost within its watershed. Previous work has found evidence for the deposition of previously frozen soils in the Colville River delta (Schreiner et al., 2014). Here, we compared the bulk organic carbon thermal properties, ages of soils and river and delta sediments from the Colville River drainage system using 14C Ramped Pyrolysis and chemical biomarkers. Our data show that deep permafrost soils as well as river and delta sediments had similar pyrograms and biomarker signatures, reflecting transport of soils from watershed to the delta. Surface soil had pyrograms indicative of less stable (more biodegradable) OC than deeper soil horizons. Similarity in pyrograms of deep soils and river sediment indicated the limited contribution of surface soils to riverine particulate OC inputs. Sediments in the delta showed inputs of yedoma (ice-rich syngenetic permafrost with large ice wedges) from the watershed sources (e.g., river bank erosion) in addition to peat inputs, that were largely from coastal erosion.
Usability, Quality, Value and E-Learning Continuance Decisions
ERIC Educational Resources Information Center
Chiu, Chao-Min; Hsu, Meng-Hsiang; Sun, Szu-Yuan; Lin, Tung-Ching; Sun, Pei-Chen
2005-01-01
Previous research suggests that an eventual information technology (IT) success depend on both its initial adoption (acceptance) and subsequent continued usage (continuance). Expectancy disconfirmation theory (EDT) has been successfully used to predict users' intention to continue using information technologies. This study proposed a decomposed…
40 CFR 63.11454 - What are the monitoring requirements for new and existing sources?
Code of Federal Regulations, 2010 CFR
2010-07-01
... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for.... (1) You must install each sensor of your monitoring system in a location that provides representative...
76 FR 52013 - Notice of Continuation of Visitor Services-Yosemite National Park
Federal Register 2010, 2011, 2012, 2013, 2014
2011-08-19
... DEPARTMENT OF THE INTERIOR National Park Service Notice of Continuation of Visitor Services--Yosemite National Park AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: Under the terms of the existing concession contract, the National Park Service intends to request a continuation of...
33 CFR 143.201 - Existing MODUs exempted from new design requirements.
Code of Federal Regulations, 2010 CFR
2010-07-01
... HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT Mobile Offshore Drilling Units § 143.201 Existing MODUs exempted from new design requirements. Any mobile offshore drilling...
NASA Astrophysics Data System (ADS)
Blume, F.; Prescott, W.; Anderson, G.; Eriksson, S.; Feldl, N.
2006-12-01
Tectonic and earthquake research in the US has experienced a quiet revolution over the last decade precipitated by the recognition that slow-motion faulting events can both trigger and be triggered by regular earthquakes. Transient motion has now been found in essentially all tectonic environments, and the detection and analysis of such events is the first-order science target of the EarthScope Project. Because of this and a host of other fundamental tectonics questions that can be answered only with long-duration geodetic time series, the incipient 1400-station EarthScope Plate Boundary Observatory (PBO) network has been designed to leverage 432 existing continuous GPS stations whose measurements extend back over a decade. The irreplaceable recording history of these stations is accelerating EarthScope scientific return by providing the highest possible resolution. This resolution will be used to detect and understand transients, to determine the three-dimensional velocity field (particularly vertical motion), and to improve measurement precision by understanding the complex noise sources inherent in GPS. The PBO Nucleus project supports the operation, maintenance and hardware upgrades of a subset of the six western U.S. geodetic networks until they are subsumed by PBO. Uninterrupted data flow from these stations will effectively double the time-series length of PBO over the expected life of EarthScope, and has created, for the first time, a single GPS-based geodetic network in the US. The other existing sites remain in operation under support from non-NSF sources (e.g. the USGS), and EarthScope continues to benefit from their continued operation. On the grounds of relevance to EarthScope science goals, geographic distribution and data quality, 209 of the 432 existing stations were selected as the nucleus upon which to build PBO. Conversion of these stations to a PBO-compatible mode of operation was begun under previous funding, and as a result data now flow directly to PBO archives and processing centers while maintenance, operations, and meta-data requirements are continuing to be upgraded to PBO standards. At the end of this project all 209 stations will be fully incorporated into PBO, meeting all standards for new PBO construction including data communications and land use permits. Funds for operation of these stations have been included in planned budgets for PBO after the construction phase ends and PBO begins an operational phase in 2008. To date approximately 150 of the 209 stations have been completely upgraded, and data flow from all stations is incorporated into the PBO data analysis flow. The community has only begun to understand the pervasive effects of transient creep, and its societal consequences remained largely unexplored. For example, one open question is whether slow faulting pervasively moderates earthquake nucleation. The existence of slow earthquakes will impact seismic hazards estimation, since these transients are now known to `absorb' a significant component of total slip in some regions and trigger earthquakes in others. The data from these stations serve a much larger audience than just the few people who work to keep them operating. This project is now collecting the data that will be used by the next generation of solid-earth researchers for at least two decades. Educational modules are being developed by a team of researchers, educators, and curriculum development professionals, and are being disseminated through regional and national workshops. An interactive website provides the newest developments in tectonics research to K-16 classrooms.
14 CFR 216.5 - Existing permits.
Code of Federal Regulations, 2010 CFR
2010-01-01
... REGULATIONS COMMINGLING OF BLIND SECTOR TRAFFIC BY FOREIGN AIR CARRIERS § 216.5 Existing permits. “Foreign..., authorizing the combined carriage of blind sector traffic as defined in this part, shall continue in effect in...
Existence of the Stark-Wannier quantum resonances
DOE Office of Scientific and Technical Information (OSTI.GOV)
Sacchetti, Andrea, E-mail: andrea.sacchetti@unimore.it
2014-12-15
In this paper, we prove the existence of the Stark-Wannier quantum resonances for one-dimensional Schrödinger operators with smooth periodic potential and small external homogeneous electric field. Such a result extends the existence result previously obtained in the case of periodic potentials with a finite number of open gaps.
22 CFR 126.12 - Continuation in force.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Continuation in force. 126.12 Section 126.12... PROVISIONS § 126.12 Continuation in force. All determinations, authorizations, licenses, approvals of... previous provisions of this subchapter, continue in full force and effect until or unless modified, revoked...
Nonlinear Light Dynamics in Multi-Core Structures
2017-02-27
be generated in continuous- discrete optical media such as multi-core optical fiber or waveguide arrays; localisation dynamics in a continuous... discrete nonlinear system. Detailed theoretical analysis is presented of the existence and stability of the discrete -continuous light bullets using a very...and pulse compression using wave collapse (self-focusing) energy localisation dynamics in a continuous- discrete nonlinear system, as implemented in a
40 CFR 63.11440 - What are the monitoring requirements for new and existing sources?
Code of Federal Regulations, 2012 CFR
2012-07-01
... exceeds 1540 °C (2800 °F), you must take corrective action according to your standard operating procedures... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for...
40 CFR 63.11440 - What are the monitoring requirements for new and existing sources?
Code of Federal Regulations, 2011 CFR
2011-07-01
... exceeds 1540 °C (2800 °F), you must take corrective action according to your standard operating procedures... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for...
The verification test was conducted oer a period of 30 days (October 1 to October 31, 2008) and involved the continuous operation of duplicate semi-continuous monitoring technologies at the Burdens Creek Air Monitoring Site, an existing ambient-air monitoring station located near...
Code of Federal Regulations, 2014 CFR
2014-07-01
... Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Mineral Wool Production Compliance with Standards § 63.1181 How do I comply...
Code of Federal Regulations, 2012 CFR
2012-07-01
... Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Mineral Wool Production Compliance with Standards § 63.1181 How do I comply...
Code of Federal Regulations, 2013 CFR
2013-07-01
... Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Mineral Wool Production Compliance with Standards § 63.1181 How do I comply...
78 FR 56693 - Agency Information Collection Activities OMB Responses
Federal Register 2010, 2011, 2012, 2013, 2014
2013-09-13
... filed comment on 08/ 13/2013. Withdrawn and Continue EPA ICR Number 1696.07; Fuels and Fuel Additives: Health-Effects Research Requirements for Manufacturers; Withdrawn from OMB and Continue existing...
Analysis of Electric Power Board of Chattanooga Smart Grid Investment
DOE Office of Scientific and Technical Information (OSTI.GOV)
Starke, Michael; Ollis, Ben; Glass, Jim
The deployment of a Smart Grid within the EPB electrical system has brought significant value to EPB customers and to EPB operations. The Smart Grid implementation has permitted the capability to automate many of the existing systems, increasing the overall efficiency and decreasing round trip time for many required operation functions. This has both reduced the cost of operations and increased the reliability of customer service. This boost in performance can be primarily linked to two main components: the communication network and the availability of data. The existence of a fiber communication backbone has opened numerous opportunities for EPB. Largemore » data sets from remote devices can be continuously polled and used to compute numerous metrics. The speed of communication has provided a pathway to sophisticated distribution automation that would not otherwise be possible. The data have been shown to provide a much broader view of the actual electrical system that was not previously available, opening many new opportunities in data analytics. This report documents many of the existing systems and operational features of the EPB system. Many of these systems have seen significant improvement with the deployment of Smart Grid technologies. The research behind this report found that in some cases, the value was directly computable or estimable for these enhancements. Currently, several ongoing research topics are under investigation within EPB. Through a grant from TVA, EPB is currently installing a 1.3MW solar photovoltaic system, which will be the first-generation asset owned by EPB.« less
Analyzing Responses of Chemical Sensor Arrays
NASA Technical Reports Server (NTRS)
Zhou, Hanying
2007-01-01
NASA is developing a third-generation electronic nose (ENose) capable of continuous monitoring of the International Space Station s cabin atmosphere for specific, harmful airborne contaminants. Previous generations of the ENose have been described in prior NASA Tech Briefs issues. Sensor selection is critical in both (prefabrication) sensor material selection and (post-fabrication) data analysis of the ENose, which detects several analytes that are difficult to detect, or that are at very low concentration ranges. Existing sensor selection approaches usually include limited statistical measures, where selectivity is more important but reliability and sensitivity are not of concern. When reliability and sensitivity can be major limiting factors in detecting target compounds reliably, the existing approach is not able to provide meaningful selection that will actually improve data analysis results. The approach and software reported here consider more statistical measures (factors) than existing approaches for a similar purpose. The result is a more balanced and robust sensor selection from a less than ideal sensor array. The software offers quick, flexible, optimal sensor selection and weighting for a variety of purposes without a time-consuming, iterative search by performing sensor calibrations to a known linear or nonlinear model, evaluating the individual sensor s statistics, scoring the individual sensor s overall performance, finding the best sensor array size to maximize class separation, finding optimal weights for the remaining sensor array, estimating limits of detection for the target compounds, evaluating fingerprint distance between group pairs, and finding the best event-detecting sensors.
Subsonic leaky Rayleigh waves at liquid-solid interfaces.
Mozhaev, V G; Weihnacht, M
2002-05-01
The paper is devoted to the study of leaky Rayleigh waves at liquid-solid interfaces close to the border of the existence domain of these modes. The real and complex roots of the secular equation are computed for interface waves at the boundary between water and a binary isotropic alloy of gold and silver with continuously variable composition. The change of composition of the alloy allows one to cross a critical velocity for the existence of leaky waves. It is shown that, contrary to popular opinion, the critical velocity does not coincide with the phase velocity of bulk waves in liquid. The true threshold velocity is found to be smaller, the correction being of about 1.45%. Attention is also drawn to the fact that using the real part of the complex phase velocity as a velocity of leaky waves gives only approximate value. The most interesting feature of the waves under consideration is the presence of energy leakage in the subsonic range of the phase velocities where, at first glance, any radiation by harmonic waves is not permitted. A simple physical explanation of this radiation with due regard for inhomogeneity of radiated and radiating waves is given. The controversial question of the existence of leaky Rayleigh waves at a water/ice interface is reexamined. It is shown that the solution considered previously as a leaky wave is in fact the solution of the bulk-wave-reflection problem for inhomogeneous waves.
NASA Astrophysics Data System (ADS)
DiCarlo, Cheryl D.; Hacker, Henry D.; Brown, Araceli; Cheramie, Rachael; Martinsen, Gary L.; Rockwell, Benjamin; Stuck, Bruce E.
2005-04-01
The past several years has seen a severe shortage of pathogen-free Indian origin rhesus macaques due to the increased requirement for this model in retroviral research. With greater than 30 years of research data accumulated using the Rhesus macaque as the model for laser eye injury there exists a need to bridge to a more readily available nonhuman primate model. Much of the data previously collected from the Rhesus monkey (Macaca mulatta) provided the basis for the American National Standards Institute (ANSI) standards for laser safety. Currently a Tri-service effort is underway to utilize the Cynomolgus monkey (Macaca fasicularis) as a replacement for the Rhesus macaque. Preliminary functional and morphological baseline data collected from multifocal electroretinography (mfERG), optical coherence tomography (OCT) and retinal cell counts were compared from a small group of monkeys and tissues to determine if significant differences existed between the species. Initial functional findings rom mfERG yielded only one difference for the n2 amplitude value which was greater in the Cynomolgus monkey. No significant differences were seen in retinal and foveal thickness, as determined by OCT scans and no significant differences were seen in ganglion cell and inner nuclear cell nuclei counts. A highly significant difference was seen in the numbers of photoreceptor nuclei with greater numbers in the Rhesus macaque. This indicates more studies should be performed to determine the impact that a model change would have on the laser bioeffects community and their ability to continue to provide minimal visible lesion data for laser safety standards. The continued goal of this project will be to provide that necessary baseline information for a seamless transition to a more readily available animal model.
Influences of Nationalism and Historical Traumatic Events on the Will-to-Live of Elderly Israelis.
Carmel, Sara; Granek, Leeat; Zamir, Alon
2016-08-01
Existing research suggests that will-to-live (WTL) is an indicator of subjective well-being (SWB), and that similar personal variables including physical and mental health, quality-of-life, and sociodemographic characteristics influence elderly people's WTL. The purpose of this qualitative study was to explore additional factors which influence older persons' WTL. Twenty-five elderly Israelis across the country were interviewed about what weakens and strengthens their WTL. The grounded theory method guided the data collection and analysis. In addition to the previously reported aspects influencing WTL, analysis resulted in two new categories: nationalism and historical traumatic events. Negative influences of nationalism-related emotions on participants' WTL included themes of disappointment with the state, with children leaving the state, and with existential insecurity. Among the positive influences on WTL, participants mentioned pride in the state and in its development, personal security, and hope for a peaceful future. Under the category of historical traumatic events, participants reported posttraumatic stress and war anxieties, as well as satisfaction and revenge in continued existence, and appreciation for life in Israel compared with life before immigrating to Israel. Our findings indicate that nationalism and feelings of personal involvement in national developments play an important role in the lives of elderly Israelis to the degree that they contribute to their SWB and motivation to continue living. Practitioners and family members can intentionally arouse and strengthen positive nationalistic feelings in the elderly as a way to maintain and promote SWB and WTL. © The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
The Relationship among Localization Skill, Existence Constancy and Object Permanence.
ERIC Educational Resources Information Center
Townes-Rosenwein, Linda
Two component skills of object permanence were studied: existence constancy -- the infants' ability to expect that an object continues to exist after it is hidden, and localization skill -- infants' ability to search in the correct place for a hidden object. Contradictions within the literature may occur because of task lability caused by failure…
ERIC Educational Resources Information Center
Enderle, Patrick J.; Smith, Mike U.; Southerland, Sherry
2009-01-01
The existence, preponderance, and stability of misconceptions related to evolution continue as foci of research in science education. In their 2006 study, Geraedts and Boersma question the existence of stable Lamarckian misconceptions in students, challenging the utility of Conceptual Change theory in addressing any such misconceptions. To support…
26 CFR 1.355-1 - Distribution of stock and securities of a controlled corporation.
Code of Federal Regulations, 2010 CFR
2010-04-01
... in income of) the shareholders and security holders, of one or more existing businesses formerly... to the separation of existing businesses that have been in active operation for at least five years.... Section 355 contemplates the continued operation of the business or businesses existing prior to the...
Jones, Hannah; Santamaria, Nick
2018-06-01
Focus on skin-to-skin contact (SSC) as a family-centered care intervention in Neonatal Intensive Special Care (NISC) Units continues to increase. Previously, SSC has been shown to improve neonatal physiological stability, support brain development, and promote bonding and attachment. Limited research exists investigating SSC duration and neonatal physiological responses. This study examined the relationship between SSC duration and the neonate's oxygen saturation, heart rate (HR), respiratory rate (RR), and temperature. An observational cohort study was conducted at The Royal Women's Hospital NISC Unit in Melbourne, Australia. For each neonate participant, 1 SSC with their parent was studied (parent convenience) and neonatal physiological parameters recorded, with a bivariate correlation used to explore the relationship between the duration of SSC and the percentage of time during SSC that the neonate's physiological variables remained within a target range. No correlation existed between the duration of SSC and the neonatal physiological variables of oxygen saturation, HR, RR, and temperature. However, neonatal oxygen requirement was more often reduced across the duration of SSC. Due to previously documented benefits to neonates physiologically from SSC, and our supportive finding that SSC reduces neonatal oxygen requirement, we believe that this study adds to the evidence to support promotion of SSC in NISC Units. The duration of SSC does not appear to negatively impact the physiological effects to the neonate. Thus, SSC should be encouraged in all NISC Units to be conducted for the length of time the parent is able. This study should be repeated with a larger sample size.
A spatial error model with continuous random effects and an application to growth convergence
NASA Astrophysics Data System (ADS)
Laurini, Márcio Poletti
2017-10-01
We propose a spatial error model with continuous random effects based on Matérn covariance functions and apply this model for the analysis of income convergence processes (β -convergence). The use of a model with continuous random effects permits a clearer visualization and interpretation of the spatial dependency patterns, avoids the problems of defining neighborhoods in spatial econometrics models, and allows projecting the spatial effects for every possible location in the continuous space, circumventing the existing aggregations in discrete lattice representations. We apply this model approach to analyze the economic growth of Brazilian municipalities between 1991 and 2010 using unconditional and conditional formulations and a spatiotemporal model of convergence. The results indicate that the estimated spatial random effects are consistent with the existence of income convergence clubs for Brazilian municipalities in this period.
40 CFR 60.1740 - What is my schedule for evaluating continuous emission monitoring systems?
Code of Federal Regulations, 2011 CFR
2011-07-01
... continuous emission monitoring systems? 60.1740 Section 60.1740 Protection of Environment ENVIRONMENTAL... evaluating continuous emission monitoring systems? (a) Conduct annual evaluations of your continuous emission monitoring systems no more than 13 months after the previous evaluation was conducted. (b) Evaluate your...
40 CFR 62.15195 - What is my schedule for evaluating continuous emission monitoring systems?
Code of Federal Regulations, 2010 CFR
2010-07-01
... continuous emission monitoring systems? 62.15195 Section 62.15195 Protection of Environment ENVIRONMENTAL... evaluating continuous emission monitoring systems? (a) Conduct annual evaluations of your continuous emission monitoring systems no more than 13 months after the previous evaluation was conducted. (b) Evaluate your...
40 CFR 62.15195 - What is my schedule for evaluating continuous emission monitoring systems?
Code of Federal Regulations, 2011 CFR
2011-07-01
... continuous emission monitoring systems? 62.15195 Section 62.15195 Protection of Environment ENVIRONMENTAL... evaluating continuous emission monitoring systems? (a) Conduct annual evaluations of your continuous emission monitoring systems no more than 13 months after the previous evaluation was conducted. (b) Evaluate your...
40 CFR 403.10 - Development and submission of NPDES State pretreatment programs.
Code of Federal Regulations, 2010 CFR
2010-07-01
... AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS GENERAL PRE-TREAT-MENT REGULATIONS FOR EXIST-ING AND... Industrial User is in compliance with Pretreatment Standards; (iv) Seek civil and criminal penalties, and...
Deployment strategies of managed lanes on arterials : [summary].
DOT National Transportation Integrated Search
2015-02-01
Floridas continuing growth has often been attracted to areas where good highway : infrastructure already exists. Traffic loads have developed to the point where widening existing : highways is not sufficient, or perhaps impossible, to accommodate ...
Mapping Tree Density at the Global Scale
NASA Astrophysics Data System (ADS)
Covey, K. R.; Crowther, T. W.; Glick, H.; Bettigole, C.; Bradford, M.
2015-12-01
The global extent and distribution of forest trees is central to our understanding of the terrestrial biosphere. We provide the first spatially continuous map of forest tree density at a global-scale. This map reveals that the global number of trees is approximately 3.04 trillion, an order of magnitude higher than the previous estimate. Of these trees, approximately 1.39 trillion exist in tropical and subtropical regions, with 0.74, and 0.61 trillion in boreal and temperate regions, respectively. Biome-level trends in tree density demonstrate the importance of climate and topography in controlling local tree densities at finer scales, as well as the overwhelming impact of humans across most of the world. Based on our projected tree densities, we estimate that deforestation is currently responsible for removing over 15 billion trees each year, and the global number of trees has fallen by approximately 46% since the start of human civilization.
Mapping tree density at a global scale
NASA Astrophysics Data System (ADS)
Crowther, T. W.; Glick, H. B.; Covey, K. R.; Bettigole, C.; Maynard, D. S.; Thomas, S. M.; Smith, J. R.; Hintler, G.; Duguid, M. C.; Amatulli, G.; Tuanmu, M.-N.; Jetz, W.; Salas, C.; Stam, C.; Piotto, D.; Tavani, R.; Green, S.; Bruce, G.; Williams, S. J.; Wiser, S. K.; Huber, M. O.; Hengeveld, G. M.; Nabuurs, G.-J.; Tikhonova, E.; Borchardt, P.; Li, C.-F.; Powrie, L. W.; Fischer, M.; Hemp, A.; Homeier, J.; Cho, P.; Vibrans, A. C.; Umunay, P. M.; Piao, S. L.; Rowe, C. W.; Ashton, M. S.; Crane, P. R.; Bradford, M. A.
2015-09-01
The global extent and distribution of forest trees is central to our understanding of the terrestrial biosphere. We provide the first spatially continuous map of forest tree density at a global scale. This map reveals that the global number of trees is approximately 3.04 trillion, an order of magnitude higher than the previous estimate. Of these trees, approximately 1.39 trillion exist in tropical and subtropical forests, with 0.74 trillion in boreal regions and 0.61 trillion in temperate regions. Biome-level trends in tree density demonstrate the importance of climate and topography in controlling local tree densities at finer scales, as well as the overwhelming effect of humans across most of the world. Based on our projected tree densities, we estimate that over 15 billion trees are cut down each year, and the global number of trees has fallen by approximately 46% since the start of human civilization.
Using leap motion to investigate the emergence of structure in speech and language.
Eryilmaz, Kerem; Little, Hannah
2017-10-01
In evolutionary linguistics, experiments using artificial signal spaces are being used to investigate the emergenceof speech structure. These signal spaces need to be continuous, non-discretized spaces from which discrete unitsand patterns can emerge. They need to be dissimilar from-but comparable with-the vocal tract, in order tominimize interference from pre-existing linguistic knowledge, while informing us about language. This is a hardbalance to strike. This article outlines a new approach that uses the Leap Motion, an infrared controller that canconvert manual movement in 3d space into sound. The signal space using this approach is more flexible than signalspaces in previous attempts. Further, output data using this approach is simpler to arrange and analyze. Theexperimental interface was built using free, and mostly open- source libraries in Python. We provide our sourcecode for other researchers as open source.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Kurnik, Charles W.; Keeling, Josh; Bruchs, Doug
Refrigerator recycling programs are designed to save energy by removing operable, albeit less efficient, refrigerators from service. By offering free pickup, providing incentives, and disseminating information about the operating cost of less efficient refrigerators, these programs are designed to encourage consumers to: - Limit the use of secondary refrigerators -Relinquish refrigerators previously used as primary units when they are replaced (rather than keeping the existing refrigerator as a secondary unit) -Prevent the continued use of less efficient refrigerators in another household through a direct transfer (giving it away or selling it) or indirect transfer (resale on the used appliance market).more » Commonly implemented by third-party contractors (who collect and decommission participating appliances), these programs generate energy savings through the retirement of inefficient appliances. The decommissioning process captures environmentally harmful refrigerants and foam, and enables recycling of the plastic, metal, and wiring components.« less
Dish Stirling solar receiver program
NASA Technical Reports Server (NTRS)
Haglund, R. A.
1980-01-01
A technology demonstration of a Dish Stirling solar thermal electric system can be accomplished earlier and at a much lower cost than previous planning had indicated by employing technical solutions that allow already existing hardware, with minimum modifications, to be integrated into a total system with a minimum of development. The DSSR operates with a modified United Stirling p-40 engine/alternator and the JPL Test Bed Concentrator as a completely integrated solar thermal electric system having a design output of 25 kWe. The system is augmented by fossil fuel combustion which ensures a continuous electrical output under all environmental conditions. Technical and economic studies by government and industry in the United States and abroad identify the Dish Stirling solar electric system as the most appropriate, efficient and economical method for conversion of solar energy to electricity in applications when the electrical demand is 10 MWe and less.
Long-Duration Low-to Medium-Altitude Solar Electric Airship Concept
NASA Technical Reports Server (NTRS)
Bents, David J.
2011-01-01
This report presents the conceptual design for a solar electric lighter-than-air, unmanned aerial vehicle, based on existing technology already reduced to practice, that could carry a 600-kg (1322-lbm) payload to altitudes up to 30 kft (9000 m), continuously maintain an airspeed up to 40 kt (21 m/sec), and remain in flight for up to 100 days. The design is based on modern nonrigid airship technology, high-strength polymer fabrics and barrier films, and previously demonstrated aerospace electrical power technology, including lightweight photovoltaics and hydrogen-air polymer electrolyte membrane (PEM) fuel cells. The vehicle concept exploits the inherent synergy between the use of hydrogen as a lifting gas and the use of hydrogen-air PEM fuel-cell technology for onboard solar energy storage. In this report, the air vehicle concept is physically characterized and its estimated performance envelope is defined
Clonal evolution in hematologic malignancies and therapeutic implications
Landau, Dan A.; Carter, Scott L.; Getz, Gad; Wu, Catherine J.
2014-01-01
The ability of cancer to evolve and adapt is a principal challenge to therapy in general, and to the paradigm of targeted therapy in particular. This ability is fueled by the co-existence of multiple, genetically heterogeneous subpopulations within the cancer cell population. Increasing evidence has supported the idea that these subpopulations are selected in a Darwinian fashion, by which the genetic landscape of the tumor is continuously reshaped. Massively parallel sequencing has enabled a recent surge in our ability to study this process, adding to previous efforts using cytogenetic methods and targeted sequencing. Altogether, these studies reveal the complex evolutionary trajectories occurring across individual hematological malignancies. They also suggest that while clonal evolution may contribute to resistance to therapy, treatment may also hasten the evolutionary process. New insights into this process challenge us to understand the impact of treatment on clonal evolution, and inspire the development of novel prognostic and therapeutic strategies. PMID:23979521
Effect of tubing on loss of clonazepam administered by continuous subcutaneous infusion.
Schneider, Jennifer J; Good, Phillip; Ravenscroft, Peter J
2006-06-01
Previous studies have reported loss of clonazepam from solutions administered intravenously from plastic infusion bags and administration sets. In palliative care, clonazepam is sometimes administered through syringe drivers using polyvinyl chloride (PVC) infusion tubing. No data currently exist to show whether use of PVC tubing affects the amount of clonazepam actually received by the patient. This study compared the use of two different types of PVC tubing with a non-PVC tubing. Solutions containing clonazepam or clonazepam and morphine were prepared with either normal saline or water for injection as diluent. Concentrations of morphine and clonazepam were determined using high-performance liquid chromatography. Significant loss of clonazepam (up to 50%) was observed in all solutions infused through PVC tubing. Solutions infused through non-PVC tubing retained greater than 90% of the initial concentration of clonazepam. It is recommended that when administering clonazepam using a syringe driver, non-PVC tubing be used.
Semi-blind Bayesian inference of CMB map and power spectrum
NASA Astrophysics Data System (ADS)
Vansyngel, Flavien; Wandelt, Benjamin D.; Cardoso, Jean-François; Benabed, Karim
2016-04-01
We present a new blind formulation of the cosmic microwave background (CMB) inference problem. The approach relies on a phenomenological model of the multifrequency microwave sky without the need for physical models of the individual components. For all-sky and high resolution data, it unifies parts of the analysis that had previously been treated separately such as component separation and power spectrum inference. We describe an efficient sampling scheme that fully explores the component separation uncertainties on the inferred CMB products such as maps and/or power spectra. External information about individual components can be incorporated as a prior giving a flexible way to progressively and continuously introduce physical component separation from a maximally blind approach. We connect our Bayesian formalism to existing approaches such as Commander, spectral mismatch independent component analysis (SMICA), and internal linear combination (ILC), and discuss possible future extensions.
Model Checking JAVA Programs Using Java Pathfinder
NASA Technical Reports Server (NTRS)
Havelund, Klaus; Pressburger, Thomas
2000-01-01
This paper describes a translator called JAVA PATHFINDER from JAVA to PROMELA, the "programming language" of the SPIN model checker. The purpose is to establish a framework for verification and debugging of JAVA programs based on model checking. This work should be seen in a broader attempt to make formal methods applicable "in the loop" of programming within NASA's areas such as space, aviation, and robotics. Our main goal is to create automated formal methods such that programmers themselves can apply these in their daily work (in the loop) without the need for specialists to manually reformulate a program into a different notation in order to analyze the program. This work is a continuation of an effort to formally verify, using SPIN, a multi-threaded operating system programmed in Lisp for the Deep-Space 1 spacecraft, and of previous work in applying existing model checkers and theorem provers to real applications.
Production of Isolated Giant Unilamellar Vesicles under High Salt Concentrations
Stein, Hannah; Spindler, Susann; Bonakdar, Navid; Wang, Chun; Sandoghdar, Vahid
2017-01-01
The cell membrane forms a dynamic and complex barrier between the living cell and its environment. However, its in vivo studies are difficult because it consists of a high variety of lipids and proteins and is continuously reorganized by the cell. Therefore, membrane model systems with precisely controlled composition are used to investigate fundamental interactions of membrane components under well-defined conditions. Giant unilamellar vesicles (GUVs) offer a powerful model system for the cell membrane, but many previous studies have been performed in unphysiologically low ionic strength solutions which might lead to altered membrane properties, protein stability and lipid-protein interaction. In the present work, we give an overview of the existing methods for GUV production and present our efforts on forming single, free floating vesicles up to several tens of μm in diameter and at high yield in various buffer solutions with physiological ionic strength and pH. PMID:28243205
[An application of the strategy results cycle to HIV/AIDS strategic planning in Latin America].
Rodríguez-García, Rosalía; Rosenberg, Hernán
2013-07-01
To describe the Strategy Results Cycle (SRC), a model that approaches planning as an ongoing cycle of seven phases that continually responds and adapts to existing evidence. Reliable sources were used for the preparation of databases and expenditure-costing data for resources needs analysis. The planning process 6-9 months to complete a national strategic plan that was informed by evidence, focused on results and costed. Knowledge transfer facilitated national leadership and stakeholders' participation. Between 2007 and 2011, 13 of 16 countries adopted the Strategy Results Cycle model. The evidence supported the identification of results and the expenditure-costing analysis improved budget allocation efficiency. The SRC facilitated purposeful participation and added value to previous planning approaches by connecting "thinking" and "doing" which resulted in national strategic plans that are designed by stakeholders, relevant to local conditions, and can guide implementation and resource mobilization.
Ferromagnetic quantum critical point in the heavy-fermion metal YbNi4(P(1-x)As(x))2.
Steppke, Alexander; Küchler, Robert; Lausberg, Stefan; Lengyel, Edit; Steinke, Lucia; Borth, Robert; Lühmann, Thomas; Krellner, Cornelius; Nicklas, Michael; Geibel, Christoph; Steglich, Frank; Brando, Manuel
2013-02-22
Unconventional superconductivity and other previously unknown phases of matter exist in the vicinity of a quantum critical point (QCP): a continuous phase change of matter at absolute zero. Intensive theoretical and experimental investigations on itinerant systems have shown that metallic ferromagnets tend to develop via either a first-order phase transition or through the formation of intermediate superconducting or inhomogeneous magnetic phases. Here, through precision low-temperature measurements, we show that the Grüneisen ratio of the heavy fermion metallic ferromagnet YbNi(4)(P(0.92)As(0.08))(2) diverges upon cooling to T = 0, indicating a ferromagnetic QCP. Our observation that this kind of instability, which is forbidden in d-electron metals, occurs in a heavy fermion system will have a large impact on the studies of quantum critical materials.
Spontaneous charged lipid transfer between lipid vesicles.
Richens, Joanna L; Tyler, Arwen I I; Barriga, Hanna M G; Bramble, Jonathan P; Law, Robert V; Brooks, Nicholas J; Seddon, John M; Ces, Oscar; O'Shea, Paul
2017-10-03
An assay to study the spontaneous charged lipid transfer between lipid vesicles is described. A donor/acceptor vesicle system is employed, where neutrally charged acceptor vesicles are fluorescently labelled with the electrostatic membrane probe Fluoresceinphosphatidylethanolamine (FPE). Upon addition of charged donor vesicles, transfer of negatively charged lipid occurs, resulting in a fluorescently detectable change in the membrane potential of the acceptor vesicles. Using this approach we have studied the transfer properties of a range of lipids, varying both the headgroup and the chain length. At the low vesicle concentrations chosen, the transfer follows a first-order process where lipid monomers are transferred presumably through the aqueous solution phase from donor to acceptor vesicle. The rate of transfer decreases with increasing chain length which is consistent with energy models previously reported for lipid monomer vesicle interactions. Our assay improves on existing methods allowing the study of a range of unmodified lipids, continuous monitoring of transfer and simplified experimental procedures.
Oscillatory Dynamics of One-Dimensional Homogeneous Granular Chains
NASA Astrophysics Data System (ADS)
Starosvetsky, Yuli; Jayaprakash, K. R.; Hasan, Md. Arif; Vakakis, Alexander F.
The acoustics of the homogeneous granular chains has been studied extensively both numerically and experimentally in the references cited in the previous chapters. This chapter focuses on the oscillatory behavior of finite dimensional homogeneous granular chains. It is well known that normal vibration modes are the building blocks of the vibrations of linear systems due to the applicability of the principle of superposition. One the other hand, nonlinear theory is deprived of such a general superposition principle (although special cases of nonlinear superpositions do exist), but nonlinear normal modes ‒ NNMs still play an important role in the forced and resonance dynamics of these systems. In their basic definition [1], NNMs were defined as time-periodic nonlinear oscillations of discrete or continuous dynamical systems where all coordinates (degrees-of-freedom) oscillate in-unison with the same frequency; further extensions of this definition have been considered to account for NNMs of systems with internal resonances [2]...
Yan, Yi; Adam, Brian; Galinski, Mary; C Kissinger, Jessica; Moreno, Alberto; Gutierrez, Juan B
2015-12-01
We developed a coupled age-structured partial differential equation model to capture the disease dynamics during blood-stage malaria. The addition of age structure for the parasite population, with respect to previous models, allows us to better characterize the interaction between the malaria parasite and red blood cells during infection. Here we prove that the system we propose is well-posed and there exist at least two global states. We further demonstrate that the numerical simulation of the system coincides with clinically observed outcomes of primary and secondary malaria infection. The well-posedness of this system guarantees that the behavior of the model remains smooth, bounded, and continuously dependent on initial conditions; calibration with clinical data will constrain domains of parameters and variables to physiological ranges. Copyright © 2015 Elsevier Inc. All rights reserved.
Particles Co-orbital to Janus and to Epimetheus: A Firefly Planetary Ring
NASA Astrophysics Data System (ADS)
Winter, Othon C.; Souza, Alexandre P. S.; Sfair, Rafael; Giuliatti Winter, Silvia M.; Mourão, Daniela C.; Foryta, Dietmar W.
2018-01-01
The Cassini spacecraft found a new and unique ring that shares the trajectory of Janus and Epimetheus, co-orbital satellites of Saturn. Performing image analysis, we found this to be a continuous ring. Its width is between 30% and 50% larger than previously announced. We also verified that the ring behaves like a firefly. It can only be seen from time to time, when Cassini, the ring, and the Sun are arranged in a particular geometric configuration, in very high phase angles. Otherwise, it remains “in the dark,” invisible to Cassini’s cameras. Through numerical simulations, we found a very short lifetime for the ring particles, less than a couple of decades. Consequently, the ring needs to be constantly replenished. Using a model of particle production due to micrometeorites impacts on the surfaces of Janus and Epimetheus, we reproduce the ring, explaining its existence and the “firefly” behavior.
Enhanced power generation and energy conversion of sewage sludge by CEA-microbial fuel cells.
Abourached, Carole; Lesnik, Keaton Larson; Liu, Hong
2014-08-01
The production of methane from sewage sludge through the use of anaerobic digestion has been able to effectively offset energy costs for wastewater treatment. However, significant energy reserves are left unrecovered and effluent standards are not met necessitating secondary processes such as aeration. In the current study a novel cloth-electrode assembly microbial fuel cell (CEA-MFC) was used to generate electricity from sewage sludge. Fermentation pretreatment of the sludge effectively increased the COD of the supernatant and improved reactor performance. Using the CEA-MFC design, a maximum power density of 1200 mW m(-2) was reached after a fermentation pre-treatment time of 96 h. This power density represents a 275% increase over those previously observed in MFC systems. Results indicate continued improvements are possible and MFCs may be a viable modification to existing wastewater treatment infrastructure. Copyright © 2014 Elsevier Ltd. All rights reserved.
"Very much evolving": a qualitative study of the views of psychiatrists about peer support workers.
Collins, Rachael; Firth, Lucy; Shakespeare, Tom
2016-06-01
Mental health services continue to develop service user involvement, including a growth in employment of peer support workers (PSWs). Despite the importance of the views and attitudes expressed by psychiatrists, this topic has not previously been studied. To gain insight into the views and attitudes psychiatrists have about PSWs. A qualitative study based on semi-structured interviews with 11 psychiatrists in the East of England. Psychiatrists were broadly positive and supportive of PSWs. Interviewees not only could anticipate a range of possible benefits of employing PSWs, but also had concerns regarding their implementation and management. There was a lack of clarity and consistency between interviewees about what the exact role of a PSW might involve. This study provides insights into how PSWs are perceived by psychiatrists. While broadly positive attitudes exist, the research highlights certain challenges, particularly role ambiguity.
Ethnic variations in pathways into early intervention services for psychosis.
Ghali, Sharif; Fisher, Helen L; Joyce, John; Major, Barnaby; Hobbs, Lorna; Soni, Sujata; Chisholm, Brock; Rahaman, Nikola; Papada, Peggy; Lawrence, Jo; Bloy, Sally; Marlowe, Karl; Aitchison, Katherine J; Power, Paddy; Johnson, Sonia
2013-04-01
Ethnic variations have previously been identified in the duration of untreated psychosis (DUP) and pathways into psychiatric services. These have not been examined in the context of early intervention services, which may alter these trajectories. To explore ethnic differences in the nature and duration of pathways into early intervention services. In a naturalistic cohort study, data were collected for 1024 individuals with psychotic disorders accepted for case management by eight London early intervention services. Duration of untreated psychosis was prolonged in the White British group compared with most other ethnic groups. White British individuals were more likely to make contact with their general practitioner and less likely to be seen within emergency medical services. All Black patient groups were more likely than their White British counterparts to experience involvement of criminal justice agencies. Variations continue to exist in how and when individuals from different ethnic groups access early intervention services. These may account for disparities in DUP.
Simplified curve fits for the thermodynamic properties of equilibrium air
NASA Technical Reports Server (NTRS)
Srinivasan, S.; Tannehill, J. C.; Weilmuenster, K. J.
1987-01-01
New, improved curve fits for the thermodynamic properties of equilibrium air have been developed. The curve fits are for pressure, speed of sound, temperature, entropy, enthalpy, density, and internal energy. These curve fits can be readily incorporated into new or existing computational fluid dynamics codes if real gas effects are desired. The curve fits are constructed from Grabau-type transition functions to model the thermodynamic surfaces in a piecewise manner. The accuracies and continuity of these curve fits are substantially improved over those of previous curve fits. These improvements are due to the incorporation of a small number of additional terms in the approximating polynomials and careful choices of the transition functions. The ranges of validity of the new curve fits are temperatures up to 25 000 K and densities from 10 to the -7 to 10 to the 3d power amagats.
The geometric Mean Value Theorem
NASA Astrophysics Data System (ADS)
de Camargo, André Pierro
2018-05-01
In a previous article published in the American Mathematical Monthly, Tucker (Amer Math Monthly. 1997; 104(3): 231-240) made severe criticism on the Mean Value Theorem and, unfortunately, the majority of calculus textbooks also do not help to improve its reputation. The standard argument for proving it seems to be applying Rolle's theorem to a function like
A 200-second quasi-periodicity after the tidal disruption of a star by a dormant black hole.
Reis, R C; Miller, J M; Reynolds, M T; Gültekin, K; Maitra, D; King, A L; Strohmayer, T E
2012-08-24
Supermassive black holes (SMBHs; mass is greater than or approximately 10(5) times that of the Sun) are known to exist at the center of most galaxies with sufficient stellar mass. In the local universe, it is possible to infer their properties from the surrounding stars or gas. However, at high redshifts we require active, continuous accretion to infer the presence of the SMBHs, which often comes in the form of long-term accretion in active galactic nuclei. SMBHs can also capture and tidally disrupt stars orbiting nearby, resulting in bright flares from otherwise quiescent black holes. Here, we report on a ~200-second x-ray quasi-periodicity around a previously dormant SMBH located in the center of a galaxy at redshift z = 0.3534. This result may open the possibility of probing general relativity beyond our local universe.
Saboo, Sugandha; Tumban, Ebenezer; Peabody, Julianne; Wafula, Denis; Peabody, David S.; Chackerian, Bryce; Muttil, Pavan
2016-01-01
Existing vaccines against human papillomavirus (HPV) require continuous cold-chain storage. Previously, we developed a bacteriophage virus-like particle (VLP) based vaccine for Human Papillomavirus (HPV) infection, which elicits broadly neutralizing antibodies against diverse HPV types. Here, we formulated these VLPs into a thermostable dry powder using a multi-component excipient system and by optimizing the spray drying parameters using a half-factorial design approach. Dry powder VLPs were stable after spray drying and after long-term storage at elevated temperatures. Immunization of mice with a single dose of reconstituted dry powder VLPs that were stored at 37°C for more than a year elicited high anti-L2 IgG antibody titers. Spray dried thermostable, broadly protective L2 bacteriophage VLPs vaccine could be accessible to remote regions of the world (where ~84% of cervical cancer patients reside) by eliminating the cold-chain requirement during transportation and storage. PMID:27019231
Mapping tree density at a global scale.
Crowther, T W; Glick, H B; Covey, K R; Bettigole, C; Maynard, D S; Thomas, S M; Smith, J R; Hintler, G; Duguid, M C; Amatulli, G; Tuanmu, M-N; Jetz, W; Salas, C; Stam, C; Piotto, D; Tavani, R; Green, S; Bruce, G; Williams, S J; Wiser, S K; Huber, M O; Hengeveld, G M; Nabuurs, G-J; Tikhonova, E; Borchardt, P; Li, C-F; Powrie, L W; Fischer, M; Hemp, A; Homeier, J; Cho, P; Vibrans, A C; Umunay, P M; Piao, S L; Rowe, C W; Ashton, M S; Crane, P R; Bradford, M A
2015-09-10
The global extent and distribution of forest trees is central to our understanding of the terrestrial biosphere. We provide the first spatially continuous map of forest tree density at a global scale. This map reveals that the global number of trees is approximately 3.04 trillion, an order of magnitude higher than the previous estimate. Of these trees, approximately 1.39 trillion exist in tropical and subtropical forests, with 0.74 trillion in boreal regions and 0.61 trillion in temperate regions. Biome-level trends in tree density demonstrate the importance of climate and topography in controlling local tree densities at finer scales, as well as the overwhelming effect of humans across most of the world. Based on our projected tree densities, we estimate that over 15 billion trees are cut down each year, and the global number of trees has fallen by approximately 46% since the start of human civilization.
Adolescents' knowledge and beliefs about pregnancy: the impact of "ENABL".
Arnold, E M; Smith, T E; Harrison, D F; Springer, D W
2000-01-01
Finding effective ways to prevent adolescent pregnancy is a concern of public health officials, educators, social workers, parents, and legislators. Numerous programs exist, but there is debate as to whether it is the specific program itself or other factors that are responsible for participants' successful outcomes. Using a quasi-experimental design, this study sought to determine which factors predicted changes in knowledge and beliefs among middle school students (N = 1,450) after exposure to Postponing Sexual Involvement (PSI), the curricular component of Education Now and Babies Later (ENABL), a pregnancy prevention program. It was found that the single most important predictor of improvement in knowledge and beliefs about pregnancy prevention was PSI itself, not background variables. The findings contradict some of the previous studies on factors impacting teenage pregnancy and lend support for the continued examination of ENABL as a promising component of pregnancy prevention efforts.
Characteristics of shock-associated fast-drift kilometric radio bursts
NASA Technical Reports Server (NTRS)
Macdowall, R. J.; Kundu, M. R.; Stone, R. G.
1987-01-01
The existence of a class of fast-drift, shock-associated (SA), kilometric radio bursts which occur at the time of metric type II emission and which are not entirely the kilometric continuation of metric type III bursts has been reported previously (Cane et al., 1981). In this paper unambiguous SA event criteria are established for the purpose of statistically comparing SA events with conventional kilometric type III bursts. Applying these criteria to all long-duration, fast-drift bursts observed by the ISEE-3 spacecraft during a 28-month interval, it is found that more than 70 percent of the events satisfying the criteria are associated with the radio signatures of coronal shocks. If a given event is associated with a metric type II or type IV burst, it is 13 times more likely to satisfy the SA criteria than an event associated only with metric type III activity.
Identifying Contingency Requirements using Obstacle Analysis on an Unpiloted Aerial Vehicle
NASA Technical Reports Server (NTRS)
Lutz, Robyn R.; Nelson, Stacy; Patterson-Hine, Ann; Frost, Chad R.; Tal, Doron
2005-01-01
This paper describes experience using Obstacle Analysis to identify contingency requirements on an unpiloted aerial vehicle. A contingency is an operational anomaly, and may or may not involve component failure. The challenges to this effort were: ( I ) rapid evolution of the system while operational, (2) incremental autonomy as capabilities were transferred from ground control to software control and (3) the eventual safety-criticality of such systems as they begin to fly over populated areas. The results reported here are preliminary but show that Obstacle Analysis helped (1) identify new contingencies that appeared as autonomy increased; (2) identify new alternatives for handling both previously known and new contingencies; and (3) investigate the continued validity of existing software requirements for contingency handling. Since many mobile, intelligent systems are built using a development process that poses the same challenges, the results appear to have applicability to other similar systems.
SCAR Radiologic Technologist Survey: analysis of technologist workforce and staffing.
Reiner, Bruce; Siegel, Eliot; Carrino, John A; McElveny, Ceela
2002-09-01
One of the greatest dilemmas facing medical imaging departments today is the worsening personnel crisis in the radiologic technologist (RT) workforce. As the volume and complexity of medical imaging studies continues to increase, an unprecedented imbalance exists between RT supply and demand. A number of etiologic factors have been postulated to contribute to this RT shortage including decreasing morale, perceived inadequacies in compensation, decreasing number of training programs, and limitations in the career ladder. Previous studies have cited improved technologist productivity as imaging departments successfully transition from film-based to filmless operation. This study was undertaken to address the impact of digital technologies (information systems, PACS, digital radiography) on technologist productivity, in an attempt to determine whether these technologies can be used to positively affect the existing RT workforce imbalance. A total of 112 facilities participated in this nationwide study, with representation of imaging providers that paralleled the demographic profile of the marketplace as a whole. Survey results indicate the existing RT staffing shortage is greatest within academic and rural-based hospitals and is most severe in the area of general radiography, which accounts for 65-70% of imaging department volumes. For general radiography alone, respondents report an average shortage of 2 RT full-time equivalents (FTE's) per institution, when comparing the number of budgeted RT FTE's versus the actual number of RT FTE's. Preliminary results indicate that at this time, RT staffing shortages are not affected by the presence or absence of digital information technologies. Additional research is planned through a five-year longitudinal data collection, to better delineate the complex relationship that exists between implementation of digital technologies and RT staffing.
Brake System Design Optimization : Volume 2. Supplemental Data.
DOT National Transportation Integrated Search
1981-04-01
Existing freight car braking systems, components, and subsystems are characterized both physically and functionally, and life-cycle costs are examined. Potential improvements to existing systems previously proposed or available are identified and des...
Brake System Design Optimization. Volume II : Supplemental Data.
DOT National Transportation Integrated Search
1981-06-01
Existing freight car braking systems, components, and subsystems are characterized both physically and functionally, and life-cycle costs are examined. Potential improvements to existing systems previously proposed or available are identified and des...
DOT National Transportation Integrated Search
2017-08-01
In continuation of a previously completed project entitled Evaluate Presawn Transverse Thermal Cracks for Asphalt Concrete Pavement, this project was a further effort to understand important variables in the thermal cracking process through continued...
Chaotic trajectories in the standard map. The concept of anti-integrability
NASA Astrophysics Data System (ADS)
Aubry, Serge; Abramovici, Gilles
1990-07-01
A rigorous proof is given in the standard map (associated with a Frenkel-Kontorowa model) for the existence of chaotic trajectories with unbounded momenta for large enough coupling constant k > k0. These chaotic trajectories (with finite entropy per site) are coded by integer sequences { mi} such that the sequence bi = |m i+1 + m i-1-2m i| be bounded by some integer b. The bound k0 in k depends on b and can be lowered for coding sequences { mi} fulfilling more restrictive conditions. The obtained chaotic trajectories correspond to stationary configurations of the Frenkel-Kontorowa model with a finite (non-zero) photon gap (called gap parameter in dimensionless units). This property implies that the trajectory (or the configuration { ui}) can be uniquely continued as a uniformly continuous function of the model parameter k in some neighborhood of the initial configuration. A non-zero gap parameter implies that the Lyapunov coefficient is strictly positive (when it is defined). In addition, the existence of dilating and contracting manifolds is proven for these chaotic trajectories. “Exotic” trajectories such as ballistic trajectories are also proven to exist as a consequence of these theorems. The concept of anti-integrability emerges from these theorems. In the anti-integrable limit which can be only defined for a discrete time dynamical system, the coordinates of the trajectory at time i do not depend on the coordinates at time i - 1. Thus, at this singular limit, the existence of chaotic trajectories is trivial and the dynamical system reduces to a Bernoulli shift. It is well known that the KAM tori of symplectic dynamical originates by continuity from the invariant tori which exists in the integrible limit (under certain conditions). In a similar way, it appears that the chaotic trajectories of dynamical systems originate by continuity from those which exists at the anti-integrable limits (also under certain conditions).
Detecting gravity waves from binary black holes
NASA Technical Reports Server (NTRS)
Wahlquist, Hugo D.
1989-01-01
One of the most attractive possible sources of strong gravitational waves would be a binary system comprising massive black holes (BH). The gravitational radiation from a binary is an elliptically polarized, periodic wave which could be observed continuously - or at intervals whenever a detector was available. This continuity of the signal is certainly appealing compared to waiting for individual pulses from infrequent random events. It also has the advantage over pulses that continued observation can increase the signal-to-noise ratio almost indefinitely. Furthermore, this system is dynamically simple; the theory of the generation of the radiation is unambiguous; all characteristics of the signal can be precisely related to the dynamical parameters of the source. The current situation is that while there is no observational evidence as yet for the existence of massive binary BH, their formation is theoretically plausible, and within certain coupled constraints of mass and location, their existence cannot be observationally excluded. Detecting gravitational waves from these objects might be the first observational proof of their existence.
Code of Federal Regulations, 2010 CFR
2010-07-01
... Continuous Lamination and Continuous Casting Lines Complying With a Percent Reduction Limit or a Lbs/Ton...: Reinforced Plastic Composites Production Pt. 63, Subpt. WWWW, Table 11 Table 11 to Subpart WWWW of Part 63... With a Percent Reduction Limit or a Lbs/Ton Limit on an Averaging Basis As required in § 63.5865, in...
40 CFR 60.5115 - How do I comply with the increment of progress for achieving final compliance?
Code of Federal Regulations, 2011 CFR
2011-07-01
... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Emission Guidelines and Compliance Times for Existing Sewage Sludge Incineration Units Model Rule...
40 CFR 60.5100 - When must I submit the notifications of achievement of increments of progress?
Code of Federal Regulations, 2011 CFR
2011-07-01
... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Emission Guidelines and Compliance Times for Existing Sewage Sludge Incineration Units Model Rule...
Mechanistic-empirical design concepts for continuously reinforced concrete pavements in Illinois.
DOT National Transportation Integrated Search
2009-04-01
The Illinois Department of Transportation (IDOT) currently has an existing jointed plain concrete pavement : (JPCP) design based on mechanistic-empirical (M-E) principles. However, their continuously reinforced concrete : pavement (CRCP) design proce...
National reregistration and the continuing competence of EMT-paramedics
DOT National Transportation Integrated Search
2006-04-01
Objective: To determine if a difference exists in the continued cognitive competence of Nationally Registered Emergency Medical Technician Paramedics (NREMT-P) who voluntarily reregistered with the NREMT (a national non-profit corporation that provid...
NASA Astrophysics Data System (ADS)
DeCelles, P. G.; Carrapa, B.; Gehrels, G. E.; Chakraborty, T.; Ghosh, P.
2016-12-01
The Himalaya consists of thrust sheets tectonically shingled together since 58 Ma as India collided with and slid beneath Asia. Major Himalayan structures, including the South Tibetan Detachment (STD), Main Central Thrust (MCT), Lesser Himalayan Duplex (LHD), Main Boundary Thrust (MBT), and Main Frontal Thrust (MFT), persist along strike from northwestern India to Arunachal Pradesh near the eastern end of the orogenic belt. Previous work suggests significant basement involvement and a kinematic history unique to the Arunachal Himalaya. We present new geologic and geochronologic data to support a regional structural cross section and kinematic restoration of the Arunachal Himalaya. Large Paleoproterozoic orthogneiss bodies (Bomdila Gneiss) previously interpreted as Indian basement have ages of 1774-1810 Ma, approximately 50 Ma younger than Lesser Himalayan strata into which their granitic protoliths intruded. Bomdila Gneiss is therefore part of the Lesser Himalayan cover sequence, and no evidence exists for basement involvement in the Arunachal Himalaya. Minimum shortening in rocks structurally beneath the STD is 421 km. The MCT was active during the early Miocene; STD extension overlapped MCT shortening and continued until approximately 15-12 Ma; and growth of the LHD began 11 Ma, followed by slip along the MBT (post-7.5 Ma) and MFT (post-1 Ma) systems. Earlier thrusting events involved long-distance transport of strong, low-taper thrust sheets, whereas events after 12-10 Ma stacked smaller, weaker thrust sheets into a steeply tapered orogenic wedge dominated by duplexing. A coeval kinematic transition is observed in other Himalayan regions, suggesting that orogenic wedge behavior was controlled by rock strength and erodibility.
Intravenous Chemotherapy Compounding Errors in a Follow-Up Pan-Canadian Observational Study.
Gilbert, Rachel E; Kozak, Melissa C; Dobish, Roxanne B; Bourrier, Venetia C; Koke, Paul M; Kukreti, Vishal; Logan, Heather A; Easty, Anthony C; Trbovich, Patricia L
2018-05-01
Intravenous (IV) compounding safety has garnered recent attention as a result of high-profile incidents, awareness efforts from the safety community, and increasingly stringent practice standards. New research with more-sensitive error detection techniques continues to reinforce that error rates with manual IV compounding are unacceptably high. In 2014, our team published an observational study that described three types of previously unrecognized and potentially catastrophic latent chemotherapy preparation errors in Canadian oncology pharmacies that would otherwise be undetectable. We expand on this research and explore whether additional potential human failures are yet to be addressed by practice standards. Field observations were conducted in four cancer center pharmacies in four Canadian provinces from January 2013 to February 2015. Human factors specialists observed and interviewed pharmacy managers, oncology pharmacists, pharmacy technicians, and pharmacy assistants as they carried out their work. Emphasis was on latent errors (potential human failures) that could lead to outcomes such as wrong drug, dose, or diluent. Given the relatively short observational period, no active failures or actual errors were observed. However, 11 latent errors in chemotherapy compounding were identified. In terms of severity, all 11 errors create the potential for a patient to receive the wrong drug or dose, which in the context of cancer care, could lead to death or permanent loss of function. Three of the 11 practices were observed in our previous study, but eight were new. Applicable Canadian and international standards and guidelines do not explicitly address many of the potentially error-prone practices observed. We observed a significant degree of risk for error in manual mixing practice. These latent errors may exist in other regions where manual compounding of IV chemotherapy takes place. Continued efforts to advance standards, guidelines, technological innovation, and chemical quality testing are needed.
78 FR 46929 - Privacy Act of 1974; System of Records
Federal Register 2010, 2011, 2012, 2013, 2014
2013-08-02
..., Continuity of Operations Plans, in its existing inventory of record systems subject to the Privacy Act of... incorporate the Continuity of Operations Office plans from agency field offices. DATES: This proposed action... of Defense. KD3D.01 System name: Continuity of Operations Plans (August 22, 2000, 65 FR 50974...
Parameter Invariance and Skill Attribute Continuity in the DINA Model
ERIC Educational Resources Information Center
Bolt, Daniel M.; Kim, Jee-Seon
2018-01-01
Cognitive diagnosis models (CDMs) typically assume skill attributes with discrete (often binary) levels of skill mastery, making the existence of skill continuity an anticipated form of model misspecification. In this article, misspecification due to skill continuity is argued to be of particular concern for several CDM applications due to the…
Darwinism and the Sexual Politics of Primates
ERIC Educational Resources Information Center
Crook, John Hurrell
1973-01-01
Discusses the continuing debate over the existing social relations between the sexes; that is, whether subordination of females to males is derived from biological differences or is brought about as a result of the existing social structure. (SB)
Periodic solution of neutral Lotka-Volterra system with periodic delays
NASA Astrophysics Data System (ADS)
Liu, Zhijun; Chen, Lansun
2006-12-01
A nonautonomous n-species Lotka-Volterra system with neutral delays is investigated. A set of verifiable sufficient conditions is derived for the existence of at least one strictly positive periodic solution of this Lotka-Volterra system by applying an existence theorem and some analysis techniques, where the assumptions of the existence theorem are different from that of Gaines and Mawhin's continuation theorem [R.E. Gaines, J.L. Mawhin, Coincidence Degree and Nonlinear Differential Equations, Springer-Verlag, Berlin, 1977] and that of abstract continuation theory for k-set contraction [W. Petryshyn, Z. Yu, Existence theorem for periodic solutions of higher order nonlinear periodic boundary value problems, Nonlinear Anal. 6 (1982) 943-969]. Moreover, a problem proposed by Freedman and Wu [H.I. Freedman, J. Wu, Periodic solution of single species models with periodic delay, SIAM J. Math. Anal. 23 (1992) 689-701] is answered.
The incidence of Crohn's disease in Cardiff over the last 75 years: an update for 1996-2005.
Gunesh, S; Thomas, G A O; Williams, G T; Roberts, A; Hawthorne, A B
2008-02-01
The incidence of Crohn's disease rose rapidly in industralized countries over the past 50 years, but it is unclear whether the incidence is still rising or has reached a plateau. To update the long-term incidence study of Crohn's disease in Cardiff for 1996-2005, to investigate whether incidence is still rising and to study changes in disease characteristics over time. Crohn's cases identified by retrospective analysis of hospital records as in previous studies in Cardiff. Two hundred and twelve cases were identified. Corrected incidence for this decade was 66 x 10(6) per year (95% confidence interval: 58-76), showing a continuing rise compared to previous decades. The proportion with colonic disease at presentation continues to rise (43%) with a corresponding fall in those with terminal ileal disease. There remains a strong female preponderance (F:M 1.6:1) as in previous studies. The incidence in children under age 16 continues to rise, and the median age at diagnosis has fallen slightly. Crohn's disease incidence continues to rise slowly in Cardiff with a continuing increase in those presenting with colonic disease, which is now the commonest disease pattern.
Brake System Design Optimization : Volume 1. A Survey and Assessment.
DOT National Transportation Integrated Search
1978-06-01
Existing freight car braking systems, components, and subsystems are characterized both physically and functionally, and life-cycle costs are examined. Potential improvements to existing systems previously proposed or available are identified and des...
2016-01-01
development requires wind tunnels and ranges that do not currently exist. Furthermore, continued technology matura- tion is needed for thermal management...designed with conceptual design engine model (at existing technology level), or existing propul- sion system, or modified propulsion system (e.g...internal cameras reading gauges and dials and switch positions , directly tapping into current or future avion- ics service buses and integrating
NASA Astrophysics Data System (ADS)
Blume, F.; Meertens, C.; Anderson, G.; Eriksson, S.; Boyce, E.
2007-12-01
Tectonic and earthquake research in the US has experienced a quiet revolution over the last decade precipitated by the recognition that slow-motion faulting events can both trigger and be triggered by regular earthquakes. Transient motion has now been found in essentially all tectonic environments, and the detection and analysis of such events is the first-order science target of the EarthScope Project. Because of this and a host of other fundamental tectonics questions that can be answered only with long-duration geodetic time series, the incipient 1100-station EarthScope Plate Boundary Observatory (PBO) network has been designed to leverage 445 existing continuous GPS stations whose measurements extend back over a decade. The irreplaceable recording history of these stations will accelerate EarthScope scientific return by providing the highest possible resolution. This resolution will be used to detect and understand transients, to determine the three-dimensional velocity field (particularly vertical motion), and to improve measurement precision by understanding the complex noise sources inherent in GPS. The PBO Nucleus project supports the operation, maintenance and hardware upgrades of a subset of the six western U.S. geodetic networks until they are subsumed by PBO. Uninterrupted data flow from these stations will effectively double the time-series length of PBO over the expected life of EarthScope, and has created, for the first time, a single GPS-based geodetic network in the US. The other existing sites remain in operation under support from non-NSF sources (e.g. the USGS), and EarthScope continues to benefit from their continued operation On the grounds of relevance to EarthScope science goals, geographic distribution and data quality, 209 of the 432 existing stations were selected as the nucleus upon which to build PBO. Conversion of these stations to a PBO-compatible mode of operation was begun under previous funding, and as a result data now flow directly to PBO archives and processing centers while maintenance, operations, and meta-data requirements are continue to be upgraded to PBO standards. At the end of this project all 209 stations will be fully incorporated into PBO, meeting all standards for new PBO construction including data communications and land use permits. Funds for operation of these stations have been included in planned budgets for PBO after the construction phase ends and PBO begins an operational phase in 2008. At this time work on the project is apporixmately 80% complete, with over 90% of the stations having been upgraded. The data from these stations serve a much larger audience than just the few people who work to keep them operating. This project is now collecting the data that will be used by the next generation of solid-earth researchers for at least two decades. Educational modules are being developed by a team of researchers, educators, and curriculum development professionals, and are being disseminated through regional and national workshops. An interactive website provides the newest developments in tectonics research to K-16 classrooms.
DOE Office of Scientific and Technical Information (OSTI.GOV)
LaFreniere, L. M.; Environmental Science Division
In April 2008, the Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA) conducted groundwater sampling for the analysis of volatile organic compounds (VOCs) in the existing network of monitoring points at Everest, Kansas (Argonne 2008). The objective of the 2008 investigation was to monitor the distribution of carbon tetrachloride contamination in groundwater previously identified in CCC/USDA site characterization and groundwater sampling studies at Everest in 2000-2006 (Argonne 2001, 2003, 2006a,b). The work at Everest is being undertaken on behalf of the CCC/USDA by Argonne National Laboratory, under the oversight of the Kansas Department of Health and Environment (KDHE).more » The findings of the 2008 investigation were as follows: (1) Measurements of groundwater levels obtained manually and through the use of automatic recorders demonstrated a consistent pattern of groundwater flow - and inferred contaminant migration - to the north-northwest from the former CCC/USDA facility toward the Nigh property, and then west-southwest from the Nigh property toward the intermittent creek that lies west of the former CCC/USDA facility and the Nigh property. (2) The range of concentrations and the areal distribution of carbon tetrachloride identified in the groundwater at Everest in April 2008 were generally consistent with previous results. The results of the 2008 sampling (reflecting the period from 2006 to 2008) and the earlier investigations at Everest (representing the period from 2000 to 2006) show that no significant downgradient extension of the carbon tetrachloride plume occurred from 2000 to 2008. (3) The slow contaminant migration indicated by the monitoring data is qualitatively consistent with the low groundwater flow rates in the Everest aquifer unit estimated previously on the basis of site-specific hydraulic testing (Argonne 2006a,b). (4) The April 2008 and earlier sampling results demonstrate that the limits of the plume have been effectively, identified by the existing network of monitoring points and have not changed significantly during the CCC/USDA investigation program. The carbon tetrachloride distribution within the plume has continued to evolve, however, with relatively constant or apparently decreasing contaminant levels at most sampling locations. In response to these findings, the KDHE requested that the CCC/USDA develop a plan for annual monitoring of the groundwater and surface water at Everest, to facilitate continued tracking of the carbon tetrachloride plume at this site (KDHE 2009a). A recommendation for annual sampling (for analyses of VOCs) of 16 existing groundwater monitoring points within and near the identified contaminant migration pathway and surface water sampling at 5 locations along the intermittent creek west (downgradient) of the identified plume was presented by the CCC/USDA (Appendix A) and approved by the KDHE (2009b) for implementation. The monitoring wells will be sampled according to the low-flow procedure, and sample preservation, shipping, and analysis activities will be consistent with previous work at Everest. The annual sampling will continue until identified conditions at the site indicate a technical justification for a change. This report summarizes the results of sampling and monitoring activities conducted at the Everest site since completion of the April 2008 groundwater sampling event (Argonne 2008). The investigations performed during the current review period (May 2008 to October 2009) were as follows: (1) With one exception, the KDHE-approved groundwater and surface water monitoring points were sampled on April 24-27, 2009. In this event, well PT1 was inadvertently sampled instead of the adjacent well MW04. This investigation represents the first groundwater and surface water sampling event performed under the current plan for annual monitoring approved by the KDHE. (2) Ongoing monitoring of the groundwater levels at Everest is performed with KDHE approval. The levels in selected monitoring wells are recorded continuously, by using downhole pressure sensors equipped with automatic data loggers, and periodically are also measured manually. Groundwater level data were recovered during the current review period on September 19, 2008, and on March 25, April 25-27, and October 20, 2009. (3) Argonne experience has demonstrated that the sampling and analysis (for VOCs) of native vegetation, and particularly tree tissues, often provides a sensitive indicator of possible carbon tetrachloride contamination in the surface water or shallow groundwater within the plant rooting zone. With the approval of the CCC/USDA, on August 28, 2009, samples of tree branch tissues were therefore collected for analyses at 18 locations along the intermittent creek west (downgradient) of the former CCC/USDA facility and the Nigh property.« less
A controlled investigation of continuing pain education for long-term care staff
Ghandehari, Omeed O; Hadjistavropoulos, Thomas; Williams, Jaime; Thorpe, Lilian; Alfano, Dennis P; Bello-Haas, Vanina Dal; Malloy, David C; Martin, Ronald R; Rahaman, Omar; Zwakhalen, Sandra MG; Carleton, R Nicholas; Hunter, Paulette V; Lix, Lisa M
2013-01-01
BACKGROUND: The underassessment and undertreatment of pain in residents of long-term care (LTC) facilities has been well documented. Gaps in staff knowledge and inaccurate beliefs have been identified as contributors. OBJECTIVES: To investigate the effectiveness of an expert-based continuing education program in pain assessment/management for LTC staff. METHODS: Participants included 131 LTC staff members who were randomly assigned to either an interactive pain education (PE) program, which addressed gaps in knowledge such as medication management, or an interactive control program consisting of general dementia education without a specific clinical focus. Participants attended three sessions, each lasting 3 h, and completed measures of pain-related knowledge and attitudes/beliefs before, immediately after and two weeks following the program. Focus groups were conducted with a subset of participants to gauge perception of the training program and barriers to implementing pain-related strategies. RESULTS: Analysis using ANOVA revealed that PE participants demonstrated larger gains compared with control participants with regard to pain knowledge and pain beliefs. Barriers to implementing pain-related strategies certainly exist. Nonetheless, qualitative analyses demonstrated that PE participants reported that they overcame many of these barriers and used pain management strategies four times more frequently than control participants. CONCLUSIONS: Contrary to previous research, the present study found that the interactive PE program was effective in changing pain beliefs and improving knowledge. Continuing PE in LTC has the potential to address knowledge gaps among front-line LTC providers. PMID:23457681
Continued Rapid Uplift at Laguna del Maule Volcanic Field (Chile) from 2007 through 2014
NASA Astrophysics Data System (ADS)
Le Mével, H.; Feigl, K. L.; Cordova, L.; DeMets, C.; Lundgren, P.
2014-12-01
The current rate of uplift at Laguna del Maule (LdM) volcanic field in Chile is among the highest ever observed geodetically for a volcano that is not actively erupting. Using data from interferometric synthetic aperture radar (InSAR) and the Global Positioning System (GPS) recorded at five continuously operating stations, we measure the deformation field with dense sampling in time (1/day) and space (1/hectare). These data track the temporal evolution of the current unrest episode from its inception (sometime between 2004 and 2007) to vertical velocities faster than 200 mm/yr that continue through (at least) July 2014. Building on our previous work, we evaluate the temporal evolution by analyzing data from InSAR (ALOS, TerraSAR-X, TanDEM-X) and GPS [http://dx.doi.org/ 10.1093/gji/ggt438]. In addition, we consider InSAR data from (ERS, ENVISAT, COSMO-Skymed, and UAVSAR), as well as constraints from magneto-telluric (MT), seismic, and gravity surveys. The goal is to test the hypothesis that a recent magma intrusion is feeding a large, existing magma reservoir. What will happen next? To address this question, we analyze the temporal evolution of deformation at other large silicic systems such as Yellowstone, Long Valley, and Three Sisters, during well-studied episodes of unrest. We consider several parameterizations, including piecewise linear, parabolic, and Gaussian functions of time. By choosing the best-fitting model, we expect to constrain the time scales of such episodes and elucidate the processes driving them.
Nichols, J.M.; Moniz, L.; Nichols, J.D.; Pecora, L.M.; Cooch, E.
2005-01-01
A number of important questions in ecology involve the possibility of interactions or ?coupling? among potential components of ecological systems. The basic question of whether two components are coupled (exhibit dynamical interdependence) is relevant to investigations of movement of animals over space, population regulation, food webs and trophic interactions, and is also useful in the design of monitoring programs. For example, in spatially extended systems, coupling among populations in different locations implies the existence of redundant information in the system and the possibility of exploiting this redundancy in the development of spatial sampling designs. One approach to the identification of coupling involves study of the purported mechanisms linking system components. Another approach is based on time series of two potential components of the same system and, in previous ecological work, has relied on linear cross-correlation analysis. Here we present two different attractor-based approaches, continuity and mutual prediction, for determining the degree to which two population time series (e.g., at different spatial locations) are coupled. Both approaches are demonstrated on a one-dimensional predator?prey model system exhibiting complex dynamics. Of particular interest is the spatial asymmetry introduced into the model as linearly declining resource for the prey over the domain of the spatial coordinate. Results from these approaches are then compared to the more standard cross-correlation analysis. In contrast to cross-correlation, both continuity and mutual prediction are clearly able to discern the asymmetry in the flow of information through this system.
Evolutionary stability in continuous nonlinear public goods games.
Molina, Chai; Earn, David J D
2017-01-01
We investigate a type of public goods games played in groups of individuals who choose how much to contribute towards the production of a common good, at a cost to themselves. In these games, the common good is produced based on the sum of contributions from all group members, then equally distributed among them. In applications, the dependence of the common good on the total contribution is often nonlinear (e.g., exhibiting synergy or diminishing returns). To date, most theoretical and experimental studies have addressed scenarios in which the set of possible contributions is discrete. However, in many real-world situations, contributions are continuous (e.g., individuals volunteering their time). The "n-player snowdrift games" that we analyze involve continuously varying contributions. We establish under what conditions populations of contributing (or "cooperating") individuals can evolve and persist. Previous work on snowdrift games, using adaptive dynamics, has found that what we term an "equally cooperative" strategy is locally convergently and evolutionarily stable. Using static evolutionary game theory, we find conditions under which this strategy is actually globally evolutionarily stable. All these results refer to stability to invasion by a single mutant. We broaden the scope of existing stability results by showing that the equally cooperative strategy is locally stable to potentially large population perturbations, i.e., allowing for the possibility that mutants make up a non-negligible proportion of the population (due, for example, to genetic drift, environmental variability or dispersal).
Joseph, Adrian; Goldrick, Stephen; Mollet, Michael; Turner, Richard; Bender, Jean; Gruber, David; Farid, Suzanne S; Titchener-Hooker, Nigel
2017-05-01
Continuous disk-stack centrifugation is typically used for the removal of cells and cellular debris from mammalian cell culture broths at manufacturing-scale. The use of scale-down methods to characterise disk-stack centrifugation performance enables substantial reductions in material requirements and allows a much wider design space to be tested than is currently possible at pilot-scale. The process of scaling down centrifugation has historically been challenging due to the difficulties in mimicking the Energy Dissipation Rates (EDRs) in typical machines. This paper describes an alternative and easy-to-assemble automated capillary-based methodology to generate levels of EDRs consistent with those found in a continuous disk-stack centrifuge. Variations in EDR were achieved through changes in capillary internal diameter and the flow rate of operation through the capillary. The EDRs found to match the levels of shear in the feed zone of a pilot-scale centrifuge using the experimental method developed in this paper (2.4×10 5 W/Kg) are consistent with those obtained through previously published computational fluid dynamic (CFD) studies (2.0×10 5 W/Kg). Furthermore, this methodology can be incorporated into existing scale-down methods to model the process performance of continuous disk-stack centrifuges. This was demonstrated through the characterisation of culture hold time, culture temperature and EDRs on centrate quality. © 2017 The Authors. Biotechnology Journal published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Assessment of undiscovered oil and gas resources in the Ventura Basin Province, California, 2016
Tennyson, Marilyn E.; Schenk, Christopher J.; Pitman, Janet K.; Lillis, Paul G.; Klett, Timothy R.; Brownfield, Michael E.; Finn, Thomas M.; Gaswirth, Stephanie B.; Hawkins, Sarah J.; Marra, Kristen R.; Mercier, Tracey J.; Le, Phuong A.; Leathers-Miller, Heidi M.
2017-10-02
The U.S. Geological Survey (USGS) completed a geology-based assessment of undiscovered, technically recoverable conventional and continuous oil and gas resources in the part of the Ventura Basin Province that lies onshore or within State waters (within 3 miles of the shoreline) of California (fig. 1). Conventional oil and gas resources are those that have migrated upward into structural or stratigraphic traps from deep zones where the oil and gas is generated; water is present below the oil or gas. Continuous accumulations, in contrast, are those in which oil or gas is pervasively present in essentially all wells that penetrate them, that may not be structurally or stratigraphically trapped, and that typically lack oil-water or gas-water contacts. They are commonly produced with well-stimulation technology, such as hydraulic fracturing, referred to as “unconventional.” The same stimulation technology, however, is also used in many conventionally trapped accumulations. We estimated both the likely range of oil and gas volumes remaining to be discovered in accumulations similar to existing conventional oil and gas fields in the Ventura Basin Province (previously assessed by Keller [1995] as 1,060 million barrels of oil [MMBO], 1,900 billion cubic feet of gas [BCFG], and 60 million barrels of natural gas liquids [MMBNGL]), and the potential for oil and gas that might be present in a continuous accumulation at extreme depth in the floor of the basin.
INFORMS Section on Location Analysis Dissertation Award Submission
DOE Office of Scientific and Technical Information (OSTI.GOV)
Waddell, Lucas
This research effort can be summarized by two main thrusts, each of which has a chapter of the dissertation dedicated to it. First, I pose a novel polyhedral approach for identifying polynomially solvable in- stances of the QAP based on an application of the reformulation-linearization technique (RLT), a general procedure for constructing mixed 0-1 linear reformulations of 0-1 pro- grams. The feasible region to the continuous relaxation of the level-1 RLT form is a polytope having a highly specialized structure. Every binary solution to the QAP is associated with an extreme point of this polytope, and the objective function valuemore » is preserved at each such point. However, there exist extreme points that do not correspond to binary solutions. The key insight is a previously unnoticed and unexpected relationship between the polyhedral structure of the continuous relaxation of the level-1 RLT representation and various classes of readily solvable instances. Specifically, we show that a variety of apparently unrelated solvable cases of the QAP can all be categorized in the following sense: each such case has an objective function which ensures that an optimal solution to the continuous relaxation of the level-1 RLT form occurs at a binary extreme point. Interestingly, there exist instances that are solvable by the level-1 RLT form which do not satisfy the conditions of these cases, so that the level-1 form theoretically identifies a richer family of solvable instances. Second, I focus on instances of the QAP known in the literature as linearizable. An instance of the QAP is defined to be linearizable if and only if the problem can be equivalently written as a linear assignment problem that preserves the objective function value at all feasible solutions. I provide an entirely new polyheral-based perspective on the concept of linearizable by showing that an instance of the QAP is linearizable if and only if a relaxed version of the continuous relaxation of the level-1 RLT form is bounded. We also shows that the level-1 RLT form can identify a richer family of solvable instances than those deemed linearizable by demonstrating that the continuous relaxation of the level-1 RLT form can have an optimal binary solution for instances that are not linearizable. As a byproduct, I use this theoretical framework to explicity, in closed form, characterize the dimensions of the level-1 RLT form and various other problem relaxations.« less
Code of Federal Regulations, 2011 CFR
2011-07-01
... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Emission Guidelines and Compliance Times for Existing Sewage Sludge Incineration Units Model Rule...
40 CFR 60.5095 - What must I include in the notifications of achievement of increments of progress?
Code of Federal Regulations, 2011 CFR
2011-07-01
... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Emission Guidelines and Compliance Times for Existing Sewage Sludge Incineration Units Model Rule...
40 CFR 147.3006 - Injection pressure for existing Class II wells authorized by rule.
Code of Federal Regulations, 2010 CFR
2010-07-01
... PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Lands of the Navajo, Ute Mountain Ute, and All Other New Mexico Tribes § 147.3006...
7 CFR 1783.1 - What is the purpose of the Revolving Fund Program?
Code of Federal Regulations, 2013 CFR
2013-01-01
... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) REVOLVING FUNDS FOR FINANCING WATER AND WASTEWATER...-development costs associated with proposed water and wastewater projects or with existing water and wastewater... existing water and wastewater systems. ...
7 CFR 1783.1 - What is the purpose of the Revolving Fund Program?
Code of Federal Regulations, 2011 CFR
2011-01-01
... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) REVOLVING FUNDS FOR FINANCING WATER AND WASTEWATER...-development costs associated with proposed water and wastewater projects or with existing water and wastewater... existing water and wastewater systems. ...
7 CFR 1783.1 - What is the purpose of the Revolving Fund Program?
Code of Federal Regulations, 2012 CFR
2012-01-01
... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) REVOLVING FUNDS FOR FINANCING WATER AND WASTEWATER...-development costs associated with proposed water and wastewater projects or with existing water and wastewater... existing water and wastewater systems. ...
7 CFR 1783.1 - What is the purpose of the Revolving Fund Program?
Code of Federal Regulations, 2014 CFR
2014-01-01
... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) REVOLVING FUNDS FOR FINANCING WATER AND WASTEWATER...-development costs associated with proposed water and wastewater projects or with existing water and wastewater... existing water and wastewater systems. ...
Proposals to Subsidize Health Insurance for the Unemployed
1998-01-01
firms with 20 or more employees to continue offering health coverage to workers who separate from the firm. However, firms may charge former employees ...employment-based health plans must make continuation coverage available to former employees and covered family members. Sepated workers may continue COBRA... workers in firms of 20 or more employees who participate in an existing employer-sponsored health plan are eligible to continue coverage under COBRA
PONS - Mobility Assistance on Footpaths for Public Transportation.
Koutny, Reinhard; Miesenberger, Klaus
2015-01-01
This paper presents an ongoing project targeting mobility support for users of public transportation including people with limited mobility. Existing approaches in this field mostly offer non-continuous guidance during the whole journey including multiple rides with different vehicles and footpaths in between at transfer points. Especially people with limited mobility, like people with disabilities and elderly people, or travelers who are not familiar with the specific route or transfer point, like tourists, often struggle with public transportation. They crave for a seamless approach covering all links of the mobility chain - the sequence of sections of the whole route - and providing comprehensive assistance throughout the whole journey. Previous projects and widespread experiences of project partners revealed that especially footpath sections are lacking proper support. In particular, the consortium identified three problem areas in existing approaches when dealing with footpath sections: (1) A lack of information, (2) a lack of orientation and (3) a lack of provision of services. In order to bridge (lat. PONS) these gaps in the mobility chain, new paradigms and technology concepts are developed to tackle the shortcomings on footpaths and combined in a toolkit to help developers of applications with focus on pedestrian navigation and public transport to improve their solutions with sustainable and state-of-the-art approaches.
Small covers of graph-associahedra and realization of cycles
NASA Astrophysics Data System (ADS)
Gaifullin, A. A.
2016-11-01
An oriented connected closed manifold M^n is called a URC-manifold if for any oriented connected closed manifold N^n of the same dimension there exists a nonzero-degree mapping of a finite-fold covering \\widehat{M}^n of M^n onto N^n. This condition is equivalent to the following: for any n-dimensional integral homology class of any topological space X, a multiple of it can be realized as the image of the fundamental class of a finite-fold covering \\widehat{M}^n of M^n under a continuous mapping f\\colon \\widehat{M}^n\\to X. In 2007 the author gave a constructive proof of Thom's classical result that a multiple of any integral homology class can be realized as an image of the fundamental class of an oriented smooth manifold. This construction yields the existence of URC-manifolds of all dimensions. For an important class of manifolds, the so-called small covers of graph-associahedra corresponding to connected graphs, we prove that either they or their two-fold orientation coverings are URC-manifolds. In particular, we obtain that the two-fold covering of the small cover of the usual Stasheff associahedron is a URC-manifold. In dimensions 4 and higher, this manifold is simpler than all the previously known URC-manifolds. Bibliography: 39 titles.
Oliveira, Eduardo Filipe; Santos-Martins, Diogo; Ribeiro, António Meireles; Brás, Natércia Fernandes; Cerqueira, Nuno Sousa; Sousa, Sérgio Filipe; Ramos, Maria João; Fernandes, Pedro Alexandrino
2016-11-01
Statins are remarkably safe and efficient medications that are the mainstay of hypercholesterolemia treatment and have proven to be an invaluable tool to lower the risk of acute cardiovascular events. These compounds are inhibitors of 3-hydroxy-methylglutaryl CoA reductase (HMG-R), the rate-limiting enzyme in cholesterol biosynthesis. In spite of their success, they present undesirable side effects and are now loosing patent protection, which provides a great opportunity for the development of new and improved statins. Areas covered: This review summarizes the new patents for HMG-R inhibitors for the 2011-2015 period. Combinations of existing statins with other drugs are also addressed, as well as novel applications of existing statins. Expert opinion: Recent efforts for the discovery of HMG-CoA-R inhibitors has resulted in several new molecules. Most of these are based on commercially available statins, including sterol and terpenoid derivatives. A few peptides have also been patented. However, the origin of the side effects caused by previous statins continues to be, to a large extent, unknown. Although the patents published in the past 5 years are promising, and might result in new drugs, there is still no way to know if they will present reduced toxicity. Only future clinical trials will answer this question.
Herrmann-Abell, Cari F.; Koppal, Mary; Roseman, Jo Ellen
2016-01-01
Modern biology has become increasingly molecular in nature, requiring students to understand basic chemical concepts. Studies show, however, that many students fail to grasp ideas about atom rearrangement and conservation during chemical reactions or the application of these ideas to biological systems. To help provide students with a better foundation, we used research-based design principles and collaborated in the development of a curricular intervention that applies chemistry ideas to living and nonliving contexts. Six eighth grade teachers and their students participated in a test of the unit during the Spring of 2013. Two of the teachers had used an earlier version of the unit the previous spring. The other four teachers were randomly assigned either to implement the unit or to continue teaching the same content using existing materials. Pre- and posttests were administered, and the data were analyzed using Rasch modeling and hierarchical linear modeling. The results showed that, when controlling for pretest score, gender, language, and ethnicity, students who used the curricular intervention performed better on the posttest than the students using existing materials. Additionally, students who participated in the intervention held fewer misconceptions. These results demonstrate the unit’s promise in improving students’ understanding of the targeted ideas. PMID:27909024
Crude production still jumping in Libya
DOE Office of Scientific and Technical Information (OSTI.GOV)
Wells, M.J.
1969-03-01
With the continued shutdown of the Suez Canal, Libya may become the world's fourth largest crude producer within the next few months, and become the leading Arab oil producing nation. Big field and terminal expansions now on hand for nearly all producing companies will raise crude capacity to over 3.8 million bpd by the end of 1969. The current year also is likely to be marked by some important changes in Libyan petroleum legislation and the basis of crude postings. All this is being reflected in Libya's growing voice in Arab oil councils. The steepness in the upward oil productionmore » curve is such that the 1968 average output of 2,599,800 bpd was a jump of 49.4% over the previous years. This gain raised Libya to sixth among the world's oil producers. A breakdown of production figures shows the amount of oil in barrels produced by the various companies in Libya for 1968. In addition to large capacity expansions now on hand for existing fields, virtually all of the producing companies, there are now several concessionaires which have made field discoveries in the past few months and who are negotiating with neighboring producers in the hopes of tying in with an existing pipeline system.« less
Schwienteck, Kathryn L.; Banks, Matthew L.
2015-01-01
Background Methamphetamine addiction is a significant public health problem for which no Food and Drug Administration-approved pharmacotherapies exist. Preclinical drug vs. food choice procedures have been predictive of clinical medication efficacy in the treatment of opioid and cocaine addiction. Whether preclinical choice procedures are predictive of candidate medication effects for other abused drugs, such as methamphetamine, remains unclear. The present study aim was to determine continuous 7-day treatment effects with the monoamine releaser d-amphetamine and the monoamine uptake inhibitor methylphenidate on methamphetamine vs. food choice.In addition, 7-day cocaine treatment effects were also examined. Methods Behavior was maintained under a concurrent schedule of food delivery (1-g pellets, fixed-ratio 100 schedule) and methamphetamine injections (0-0.32 mg/kg/injection, fixed-ratio 10 schedule) in male rhesus monkeys (n=4). Methamphetamine choice dose-effect functions were determined daily before and during 7-day periods of continuous intravenous treatment with d-amphetamine (0.01-0.1 mg/kg/h), methylphenidate (0.032-0.32 mg/kg/h), or cocaine (0.1-0.32 mg/kg/h). Results During saline treatment, increasing methamphetamine doses resulted in a corresponding increase in methamphetamine vs. food choice. Continuous 7-day treatments with d-amphetamine, methylphenidate or cocaine did not significantly attenuate methamphetamine vs. food choice up to doses that decreased rates of operant responding. However, 0.1 mg/kg/h d-amphetamine did eliminate methamphetamine choice in two monkeys. Conclusions The present subchronic treatment resultssupport the utility of preclinical methamphetamine choice to evaluate candidate medications for methamphetamine addiction. Furthermore, these results confirm and extend previous results demonstrating differential pharmacological mechanisms between cocaine choice and methamphetamine choice. PMID:26361713
Schwienteck, Kathryn L; Banks, Matthew L
2015-10-01
Methamphetamine addiction is a significant public health problem for which no Food and Drug Administration-approved pharmacotherapies exist. Preclinical drug vs. food choice procedures have been predictive of clinical medication efficacy in the treatment of opioid and cocaine addiction. Whether preclinical choice procedures are predictive of candidate medication effects for other abused drugs, such as methamphetamine, remains unclear. The present study aim was to determine continuous 7-day treatment effects with the monoamine releaser d-amphetamine and the monoamine uptake inhibitor methylphenidate on methamphetamine vs. food choice. In addition, 7-day cocaine treatment effects were also examined. Behavior was maintained under a concurrent schedule of food delivery (1-g pellets, fixed-ratio 100 schedule) and methamphetamine injections (0-0.32mg/kg/injection, fixed-ratio 10 schedule) in male rhesus monkeys (n=4). Methamphetamine choice dose-effect functions were determined daily before and during 7-day periods of continuous intravenous treatment with d-amphetamine (0.01-0.1mg/kg/h), methylphenidate (0.032-0.32mg/kg/h), or cocaine (0.1-0.32mg/kg/h). During saline treatment, increasing methamphetamine doses resulted in a corresponding increase in methamphetamine vs. food choice. Continuous 7-day treatments with d-amphetamine, methylphenidate or cocaine did not significantly attenuate methamphetamine vs. food choice up to doses that decreased rates of operant responding. However, 0.1mg/kg/h d-amphetamine did eliminate methamphetamine choice in two monkeys. The present subchronic treatment results support the utility of preclinical methamphetamine choice to evaluate candidate medications for methamphetamine addiction. Furthermore, these results confirm and extend previous results demonstrating differential pharmacological mechanisms between cocaine choice and methamphetamine choice. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
NASA Astrophysics Data System (ADS)
Martindale, D.; Evans, J. P.
2002-12-01
Past historical analyses of the 1857 Forth Tejon earthquake include Townley and Allen (1939); Wood (1955) re-examined the earthquake and added some additional new material, and Agnew and Sieh (1978) published an extensive review of the previous publications and included primary sources not formerly known. Since 1978, most authors have reiterated the findings of Agnew and Sieh, with the exception of Meltzner and Wald's 1998 work that built on Sieh's foreshock research and included an extensive study of aftershocks. Approximately twenty-five years has past since the last full investigation of the event. In the last several decades, libraries and archives have continued to gather additional documents. Staff members continually inventory new and existing collections, making them accessible to researchers today. As a result, we are conducting an updated examination, with the hope of new insight regarding the 1857 Fort Tejon earthquake. We use a new approached to the topic: the research skills of a historian in collaboration with a geologist to generate quantitative data on the nature and location of ground shaking associated with the earthquake. We analyze documents from the Huntington Library, California State Historical Society, California State Library-California Room, Utah Historical Association Information Center, the Church of Jesus Christ of Latter-day Saints (LDS) Archives and Historical Department, Cal Tech Archives, the National Archives, and the Fort Tejon State Park. New facilities reviewed also include Utah State University, University of Utah, and the LDS Family History Center. Each facility not only provided formerly quoted sources, but many offered new materials. For example, previous scholars examined popular, well-known newspapers; yet, publications in smaller towns and in languages other than English, also existed. Thirty newspapers published in January 1857 were located. We find records of the event at least one year after the earthquake. One outcome of such a search includes letters, approximately eight pictures useful in structure-damage analysis. Over 170 newspapers were published during 1857 throughout California, Nevada, and New Mexico Territory, encompassing the area of Arizona and New Mexico today. Historical information regarding the settlement of areas also proved useful. Although earlier scholars knew of LDS settlement missions in San Bernardino, California and Las Vegas, Nevada, only brief information was located. Preliminary results include increasing the felt area to include Las Vegas, Nevada; support for a Mercalli Index of IX or even X for San Bernardino; VIII or greater for sites NE of Sacramento, a northwest to southeast rupture pattern, and reports of electromagnetic disturbances. Based on these results, we suggest that the 1857 Ft. Tejon earthquake be felt over a wider area, and in places created greater ground shaking, than previously documented.
NASA Astrophysics Data System (ADS)
Alvarez, Román; López-Loera, Héctor; Arzate, Jorge
2010-06-01
An existing aeromagnetic survey flown on the central, western portion of Mexico did not include an important tectonic structure: Bahía de Banderas. The bay has an extension of approximately 1400 km 2 and is located within the Puerto Vallarta batholith, a granitic structure of Cretaceous origin. We report here the additional gathering of 5523 magnetic values on the bay, in order to complement the existing land aeromagnetic information; this allowed modeling the structure of the bay from the magnetic viewpoint. A late Miocene age has been proposed for the bay making it roughly contemporaneous with the first stages of separation of Baja California from mainland Mexico. Initially proposed as a graben, it was subsequently shown that its structure actually corresponds to a half-graben of the fault growth type, with reverse drag geometry; it appears to have been developed in response to an extensional process in the ˜ N-S direction. Valle de Banderas neighbors the bay constituting its eastern land continuation; it has also been proposed as a graben and it is also likely the result of an extensional process. However, it seems to be a structure more recently formed, probably around 5 Ma. The different time origin of the bay and of the valley is strengthened by the different alignment of the valley axis, where Ameca River flows and discharges into the bay, of around 30° from the trace of Banderas fault. The magnetic responses of the valley, aeromagnetic and terrestrial, support the existence of an extensional process. Upward and downward continuations of the magnetic fields show that Sierra de Vallejo and Sierra de Zapotán, to the NW of the valley, are deeply rooted structures and their magnetic responses are similar to those obtained in the Puerto Vallarta batholith; these characteristics support a common origin for them. Three magnetic profiles trending NNW are modeled across Bahía de Banderas. The models identify the structure as a half-graben with a listric main fault and reverse drag geometry, just as it was previously obtained elsewhere by an independent modeling process.
NASA Astrophysics Data System (ADS)
Dausz, K.; Dittmann, S. T.; Feaux, K.; von Hillebrandt-Andrade, C.; Mattioli, G. S.; Normandeau, J.
2014-12-01
The Continually Operating Caribbean GPS Observational Network (COCONet) is a National Science Foundation (NSF) funded multi-hazard geodetic and meteorological network distributed throughout the Caribbean, which provides infrastructure and capacity building for a broad range of earth science questions. The network is a multi-national collaboration consisting of 46 newly constructed continuous Global Positioning Systems (cGPS) and 21 refurbished existing GPS stations, all co-located with meteorological sensors. One recommendation of the COCONet working group was to improve the vertical reference frame for long-term sea level monitoring. A COCONet supplement was awarded by the NSF to further address this particular objective through the co-location of GPS and tide gauges. This COCOnet infrastructure, along with the new tide gauges, will have broad scientific implications for hazards mitigation, solid earth, and atmospheric science research. UNAVCO engineers have meet with members of the Caribbean tide gauge community to establish target locations and design station layout. Allocated NSF funds allow for the construction of two complete new tide gauge systems each with two complimentary cGPS. Following the recommendations of NOAA and the sea level monitoring community, the two "new" locales will be Port Royal, Jamaica and Puerto Morelos, Mexico. Both locations had previously existing, but currently non-operational tide gauges. UNAVCO engineers will install a Sutron Radar Level Recorder and a backup pressure sensor tide gauge with GOES satellite telemetry. Tide data will be freely available by the Intergovernmental Oceanographic Commission (www.ioc-sealevelmonitoring.org). The NSF supplement also provided funds for adding cGPS to two additional locations where currently functioning tide gauge systems exist. Proposed locations for this additional infrastructure are Barahona, Dominican Republic and Bocas del Toro, Panama. All four locations will feature two standard COCONet cGPS systems consisting of a Trimble Choke Ring GNSS antenna, Trimble NetR9 GPS receiver, and a Vaisala meteorological sensor. All GPS data will be collected, processed and distributed via standard COCONet archiving and processing along with raw meteorological data at coconet.unavco.org.
Federal metering data analysis needs and existing tools
DOE Office of Scientific and Technical Information (OSTI.GOV)
Henderson, Jordan W.; Fowler, Kimberly M.
2015-07-01
Agencies have been working to improve their metering data collection, management, and analysis efforts over the last decade (since EPAct 2005) and will continue to address these challenges as new requirements and data needs come into place. Unfortunately there is no “one-size-fits-all” solution. As agencies continue to expand their capabilities to use metered consumption data to reducing resource use and improve operations, the hope is that shared knowledge will empower others to follow suit. This paper discusses the Federal metering data analysis needs and some existing tools.
A game-theoretic model is proposed for the generalization of a discrete-fire silent duel to a silent duel with continuous firing. This zero-sum two...person game is solved in the symmetric case. It is shown that pure optimal strategies exist and hence also solve a noisy duel with continuous firing. A solution for the general non-symmetric duel is conjectured. (Author)
What Do Trade Unions Think about Continuing Education for Teachers in Galicia?
ERIC Educational Resources Information Center
Ampudia, Baena; Tilve, Ana Ma. Fernandez; Dolores, Ma.
2016-01-01
The common ups and downs of school agendas coupled with the existence of new educational challenges have created a complicated scenario that places the issue of continuing education for teaching staff directly under the spotlight. As a consequence, the role of teachers' trade unions as with other requirements of continuing education is now put…
Strategies for conserving forest genetic resources in the face of climate change
John Bradley St. Clair; Glenn Thomas Howe
2011-01-01
Conservation of genetic diversity is important for continued evolution of populations to new environments, as well as continued availability of traits of interest in genetic improvement programs. Rapidly changing climates present new threats to the conservation of forest genetic resources. We can no longer assume that in situ reserves will continue to preserve existing...
ERIC Educational Resources Information Center
Halfond, Jay A.; Moore, Thomas E.
2009-01-01
A significant component of continuing education involves teaching management, especially through the array of academic degree programs offered to part-time older students. In fact, the ability to offer management education is critical for the viability of continuing education. Co-existing amicably with its institution's business schools is the…
NASA Astrophysics Data System (ADS)
Sanskrityayn, Abhishek; Suk, Heejun; Kumar, Naveen
2017-04-01
In this study, analytical solutions of one-dimensional pollutant transport originating from instantaneous and continuous point sources were developed in groundwater and riverine flow using both Green's Function Method (GFM) and pertinent coordinate transformation method. Dispersion coefficient and flow velocity are considered spatially and temporally dependent. The spatial dependence of the velocity is linear, non-homogeneous and that of dispersion coefficient is square of that of velocity, while the temporal dependence is considered linear, exponentially and asymptotically decelerating and accelerating. Our proposed analytical solutions are derived for three different situations depending on variations of dispersion coefficient and velocity, respectively which can represent real physical processes occurring in groundwater and riverine systems. First case refers to steady solute transport situation in steady flow in which dispersion coefficient and velocity are only spatially dependent. The second case represents transient solute transport in steady flow in which dispersion coefficient is spatially and temporally dependent while the velocity is spatially dependent. Finally, the third case indicates transient solute transport in unsteady flow in which both dispersion coefficient and velocity are spatially and temporally dependent. The present paper demonstrates the concentration distribution behavior from a point source in realistically occurring flow domains of hydrological systems including groundwater and riverine water in which the dispersivity of pollutant's mass is affected by heterogeneity of the medium as well as by other factors like velocity fluctuations, while velocity is influenced by water table slope and recharge rate. Such capabilities give the proposed method's superiority about application of various hydrological problems to be solved over other previously existing analytical solutions. Especially, to author's knowledge, any other solution doesn't exist for both spatially and temporally variations of dispersion coefficient and velocity. In this study, the existing analytical solutions from previous widely known studies are used for comparison as validation tools to verify the proposed analytical solution as well as the numerical code of the Two-Dimensional Subsurface Flow, Fate and Transport of Microbes and Chemicals (2DFATMIC) code and the developed 1D finite difference code (FDM). All such solutions show perfect match with the respective proposed solutions.
NASA Astrophysics Data System (ADS)
Paul, Andre N.; Spikings, Richard A.; Ulianov, Alexey; Ovtcharova, Maria
2018-05-01
Quantitative reconstruction of thermal histories can be a powerful tool to study numerous natural processes such as tectonic plate interaction, cratonic stability and extra-terrestrial phenomena such as asteroid ejection. A majority of thermochronological studies have focused on temperatures lower than 300 °C. Few previous studies have demonstrated that U-Pb data from apatite and other accessory phases can be used to recover thermal history information at T > 350 °C. We present U-Pb data from apatite, to constrain the thermal histories of Triassic peralluminous anatectites from the Northern Andes between the temperatures of ∼350-550 °C. The accuracy of the thermal history models is assessed by comparisons with previous geological models, and comparisons with pre-existing and newly acquired U/Pb (titanite and rutile), 40Ar/39Ar (muscovite) and low temperature thermochronological data. This study also examines the feasibility of using a large, regionally dispersed apatite U-Pb data set to obtain continuous thermal history paths along a long-lived (>500 Ma) active margin. A second aim of this study is to further test the hypothesis that the dominant mechanism for Pb displacement through apatite is volume diffusion, as opposed to aqueous fluid interaction. The thermal history models derived from the Triassic anatectites exposed in the Andes of Colombia and Ecuador are entirely consistent with lower temperature thermochronological constraints, and previously established geochronological and geochemical constraints. They reveal and quantify trench parallel changes in the amount of Jurassic - Early Cretaceous extension, significantly bolstering and adding to previous tectonic interpretations. Confirmation of the utility of U-Pb thermochronology provides geologists with a powerful tool for investigating the high-temperature thermal evolution of accessory minerals.
Existence of periodic solutions in a model of respiratory syncytial virus RSV
NASA Astrophysics Data System (ADS)
Arenas, Abraham J.; González, Gilberto; Jódar, Lucas
2008-08-01
In this paper we study the existence of a positive periodic solutions for nested models of respiratory syncytial virus RSV, by using a continuation theorem based on coincidence degree theory. Conditions for the existence of periodic solutions in the model are given. Numerical simulations related to the transmission of respiratory syncytial virus in Madrid and Rio Janeiro are included.
40 CFR 147.3004 - Duration of rule authorization for existing Class I and III wells.
Code of Federal Regulations, 2010 CFR
2010-07-01
... PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Lands of the Navajo, Ute Mountain Ute, and All Other New Mexico Tribes § 147.3004...
Code of Federal Regulations, 2010 CFR
2010-07-01
...) Establish new DeCA facilities or use existing facilities of the Military Departments, as deemed necessary, for improved effectiveness and economy. (f) Exercise the operational and administrative authorities... Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) ORGANIZATIONAL...
40 CFR 427.54 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 30 2011-07-01 2011-07-01 false Pretreatment standards for existing sources. 427.54 Section 427.54 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos Millboard...
40 CFR 427.54 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Pretreatment standards for existing sources. 427.54 Section 427.54 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos Millboard...
47 CFR 22.165 - Additional transmitters for existing systems.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 47 Telecommunication 2 2010-10-01 2010-10-01 false Additional transmitters for existing systems. 22.165 Section 22.165 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PUBLIC MOBILE SERVICES Licensing Requirements and Procedures Applications and Notifications § 22...
40 CFR 461.44 - Pretreatment standards for existing sources (PSES).
Code of Federal Regulations, 2012 CFR
2012-07-01
...) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) BATTERY MANUFACTURING POINT SOURCE CATEGORY Leclanche... for existing sources listed below: (1) Subpart D—Foliar Battery Miscellaneous Wash—PSES. Pollutant or... battery manufacturing operation other than those battery manufacturing operations listed above. [49 FR...