Correlation of laboratory and production freeze drying cycles.

PubMed

Kuu, Wei Y; Hardwick, Lisa M; Akers, Michael J

2005-09-30

The purpose of this study was to develop the correlation of cycle parameters between a laboratory and a production freeze-dryer. With the established correlation, key cycle parameters obtained using a laboratory dryer may be converted to those for a production dryer with minimal experimental efforts. In order to develop the correlation, it was important to consider the contributions from the following freeze-drying components: (1) the dryer, (2) the vial, and (3) the formulation. The critical parameters for the dryer are the shelf heat transfer coefficient and shelf surface radiation emissivity. The critical parameters for the vial are the vial bottom heat transfer coefficients (the contact parameter Kcs and separation distance lv), and vial top heat transfer coefficient. The critical parameter of the formulation is the dry layer mass transfer coefficient. The above heat and mass transfer coefficients were determined by freeze-drying experiments in conjunction with mathematical modeling. With the obtained heat and mass transfer coefficients, the maximum product temperature, Tbmax, during primary drying was simulated using a primary drying subroutine as a function of the shelf temperature and chamber pressure. The required shelf temperature and chamber pressure, in order to perform a successful cycle run without product collapse, were then simulated based on the resulting values of Tbmax. The established correlation approach was demonstrated by the primary drying of the model formulation 5% mannitol solution. The cycle runs were performed using a LyoStar dryer as the laboratory dryer and a BOC Edwards dryer as the production dryer. The determined normalized dried layer mass transfer resistance for 5% mannitol is expressed as RpN=0.7313+17.19l, where l is the receding dry layer thickness. After demonstrating the correlation approach using the model formulation 5% mannitol, a practical comparison study was performed for the actual product, the lactate dehydrogenase (LDH) formulation. The determined normalized dried layer mass transfer resistance for the LDH formulation is expressed as RpN=4.344+10.85l. The operational templates Tbmax and primary drying time were also generated by simulation. The cycle run for the LDH formulation using the Edwards production dryer verified that the cycle developed in a laboratory freeze-dryer was transferable at the production scale.

Investigation of Primary Mirror Segment's Residual Errors for the Thirty Meter Telescope

NASA Technical Reports Server (NTRS)

Seo, Byoung-Joon; Nissly, Carl; Angeli, George; MacMynowski, Doug; Sigrist, Norbert; Troy, Mitchell; Williams, Eric

2009-01-01

The primary mirror segment aberrations after shape corrections with warping harness have been identified as the single largest error term in the Thirty Meter Telescope (TMT) image quality error budget. In order to better understand the likely errors and how they will impact the telescope performance we have performed detailed simulations. We first generated unwarped primary mirror segment surface shapes that met TMT specifications. Then we used the predicted warping harness influence functions and a Shack-Hartmann wavefront sensor model to determine estimates for the 492 corrected segment surfaces that make up the TMT primary mirror. Surface and control parameters, as well as the number of subapertures were varied to explore the parameter space. The corrected segment shapes were then passed to an optical TMT model built using the Jet Propulsion Laboratory (JPL) developed Modeling and Analysis for Controlled Optical Systems (MACOS) ray-trace simulator. The generated exit pupil wavefront error maps provided RMS wavefront error and image-plane characteristics like the Normalized Point Source Sensitivity (PSSN). The results have been used to optimize the segment shape correction and wavefront sensor designs as well as provide input to the TMT systems engineering error budgets.

Methylphenidate use and school performance among primary school children: a descriptive study.

PubMed

van der Schans, Jurjen; Çiçek, Rukiye; Vardar, Sefike; Bos, Jens Hj; de Vries, Tjalling W; Hoekstra, Pieter J; Hak, Eelko

2017-03-29

There is no conclusive evidence that stimulants have beneficial effects on major associated outcome parameters, particularly school performance. We assessed the differences in school performance among children using methylphenidate at the end of primary school in relation to various parameters of methylphenidate use. We linked children from a pharmacy prescription database with standardized achievement test results at the end of primary school. We explored differences in test scores between current methylphenidate users versus never users and methylphenidate users who stopped treatment at least 6 months before the test, early versus late starters, different dosage of methylphenidate, and concurrent antipsychotic or asthma treatment. Out of the 7736 children, 377 (4.9%) children were treated with methylphenidate at the time of the test. After adjusting for confounders the methylphenidate users (532.58 ± .48) performed significantly lower on the test than never users (534.72 ± .11). Compared with late starters of methylphenidate treatment (536.94 ± 1.51) we found significantly lower test scores for the early starters (532.33 ± .50). Our study indicates that children using methylphenidate still perform less at school compared to their peers. Our study also suggests that earlier start of methylphenidate treatment is associated with a lower school performance compared to children starting later with the treatment. This result could either indicate a limited effect of long term treatment or a more strongly affected group of early starters.

Inherent Safety Characteristics of Advanced Fast Reactors

NASA Astrophysics Data System (ADS)

Bochkarev, A. S.; Korsun, A. S.; Kharitonov, V. S.; Alekseev, P. N.

2017-01-01

The study presents SFR transient performance for ULOF events initiated by pump trip and pump seizure with simultaneous failure of all shutdown systems in both cases. The most severe cases leading to the pin cladding rupture and possible sodium boiling are demonstrated. The impact of various features on SFR inherent safety performance for ULOF events was analysed. The decrease in hydraulic resistance of primary loop and increase in primary pump coast down time were investigated. Performing analysis resulted in a set of recommendations to varying parameters for the purpose of enhancing the inherent safety performance of SFR. In order to prevent the safety barrier rupture for ULOF events the set of thermal hydraulic criteria defining the ULOF transient processes dynamics and requirements to these criteria were recommended based on achieved results: primary sodium flow dip under the natural circulation asymptotic level and natural circulation rise time.

Financial Indicators of Reduced Impact Logging Performance in Brazil: Case Study Comparisons

Treesearch

Thomas P. Holmes; Frederick Boltz; Douglas R. Carter

2001-01-01

Indicators of financial performance are compared for three case studies in the Brazilian Amazon. Each case study presents parameters obtained from monitoring initial harvest entries into primary forests for reduced impact logging (RIL) and conventional logging (CL) operations. Differences in cost definitions and data collection protocols complicate the analysis, and...

Performance Parameters Analysis of an XD3P Peugeot Engine Using Artificial Neural Networks (ANN) Concept in MATLAB

NASA Astrophysics Data System (ADS)

Rangaswamy, T.; Vidhyashankar, S.; Madhusudan, M.; Bharath Shekar, H. R.

2015-04-01

The current trends of engineering follow the basic rule of innovation in mechanical engineering aspects. For the engineers to be efficient, problem solving aspects need to be viewed in a multidimensional perspective. One such methodology implemented is the fusion of technologies from other disciplines in order to solve the problems. This paper mainly deals with the application of Neural Networks in order to analyze the performance parameters of an XD3P Peugeot engine (used in Ministry of Defence). The basic propaganda of the work is divided into two main working stages. In the former stage, experimentation of an IC engine is carried out in order to obtain the primary data. In the latter stage the primary database formed is used to design and implement a predictive neural network in order to analyze the output parameters variation with respect to each other. A mathematical governing equation for the neural network is obtained. The obtained polynomial equation describes the characteristic behavior of the built neural network system. Finally, a comparative study of the results is carried out.

Evaluation of fuel cell system efficiency and degradation at development and during commercialization

NASA Astrophysics Data System (ADS)

Gemmen, R. S.; Johnson, C. D.

Two primary parameters stand out for characterizing fuel cell system performance. The first and most important parameter is system efficiency. This parameter is relatively easy to define, and protocols for its assessment are already available. Another important parameter yet to be fully considered is system degradation. Degradation is important because customers desire to know how long their purchased fuel cell unit will last. The measure of degradation describes this performance factor by quantifying, for example, how the efficiency of the unit degrades over time. While both efficiency and degradation concepts are readily understood, the coupling between these two parameters must also be understood so that proper testing and evaluation of fuel cell systems is achieved. Tests not properly performed, and results not properly understood, may result in improper use of the evaluation data, producing improper R&D planning decisions and financial investments. This paper presents an analysis of system degradation, recommends an approach to its measurement, and shows how these two parameters are related and how one can be "traded-off" for the other.

EER, COP, and the Second Law Efficiency for Air Conditioners

ERIC Educational Resources Information Center

Leff, Harvey S.; Teeters, William D.

1978-01-01

Describes the relationship existing between coefficient of performance (COP) and energy efficiency ratio (EER) in air conditioning units and introduces new efficiency parameters measured relative to the energy extracted from the primary energy source. (SL)

Study of the electromagnetic characteristics of multiple HTSPPT modules based on the configuration of toroidal structure for inductive pulsed power supply

NASA Astrophysics Data System (ADS)

Zhang, Cunshan; Zheng, Xinxin; Li, Haitao; Li, Zhenmei; Zhang, Tao; Jiao, Can

2018-04-01

High temperature superconducting pulsed power transformer (HTSPPT) is an important device for pulsed power supplies. It consists of a superconducting primary and a normal conducting secondary, which is used for energy storage and current amplification. The critical current density, the energy storage, and the coupling coefficient are three main performance indexes. They are affected by the geometry parameters of HTSPPT modules, such as the height and the width of the superconducting coils. In addition, the hoop stress of the HTSPPT coils is limited by the maximum tensile strength of high temperature superconducting (HTS) tapes. In this paper, Bi-2223/Ag HTS tapes are selected as the wire of primary inductor and the toroidal structure model is selected for multiple HTSPPT modules. The relationships between the geometry parameters of HTSPPT modules and the electrical performance are studied.

An approximate generalized linear model with random effects for informative missing data.

PubMed

Follmann, D; Wu, M

1995-03-01

This paper develops a class of models to deal with missing data from longitudinal studies. We assume that separate models for the primary response and missingness (e.g., number of missed visits) are linked by a common random parameter. Such models have been developed in the econometrics (Heckman, 1979, Econometrica 47, 153-161) and biostatistics (Wu and Carroll, 1988, Biometrics 44, 175-188) literature for a Gaussian primary response. We allow the primary response, conditional on the random parameter, to follow a generalized linear model and approximate the generalized linear model by conditioning on the data that describes missingness. The resultant approximation is a mixed generalized linear model with possibly heterogeneous random effects. An example is given to illustrate the approximate approach, and simulations are performed to critique the adequacy of the approximation for repeated binary data.

Comparison of Non-Invasive Individual Monitoring of the Training and Health of Athletes with Commercially Available Wearable Technologies

PubMed Central

Düking, Peter; Hotho, Andreas; Holmberg, Hans-Christer; Fuss, Franz Konstantin; Sperlich, Billy

2016-01-01

Athletes adapt their training daily to optimize performance, as well as avoid fatigue, overtraining and other undesirable effects on their health. To optimize training load, each athlete must take his/her own personal objective and subjective characteristics into consideration and an increasing number of wearable technologies (wearables) provide convenient monitoring of various parameters. Accordingly, it is important to help athletes decide which parameters are of primary interest and which wearables can monitor these parameters most effectively. Here, we discuss the wearable technologies available for non-invasive monitoring of various parameters concerning an athlete's training and health. On the basis of these considerations, we suggest directions for future development. Furthermore, we propose that a combination of several wearables is most effective for accessing all relevant parameters, disturbing the athlete as little as possible, and optimizing performance and promoting health. PMID:27014077

Effect of feeding on the pharmacokinetics of oral minocycline in healthy research dogs.

PubMed

Hnot, Melanie L; Cole, Lynette K; Lorch, Gwendolen; Rajala-Schultz, Paivi J; Papich, Mark G

2015-12-01

The effect of food on minocycline oral absorption in dogs is unknown. The objective was to determine the pharmacokinetics of minocycline after administration of a single oral dose in fed and fasted dogs. Ten research hounds were administered oral minocycline (approximately 5 mg/kg) with and without food, in a crossover study, with a one-week wash-out between treatments. Blood samples were collected immediately prior to minocycline administration and over 24 h. Minocycline plasma drug concentrations were measured using high-performance liquid chromatography using ultraviolet detection and were analysed with compartmental modelling to determine primary pharmacokinetic parameters. Each dog was analysed independently, followed by calculation of means and variation of the dogs. The Wilcoxon signed-rank test [analysing secondary pharmacokinetic parameters - peak concentration (CMAX ), area under the concentration versus time curve (AUC)] was used to compare the two groups. A population pharmacokinetic modelling approach was performed using nonlinear mixed effects modelling of primary parameters for the population as fixed effects and the difference between subjects as a random effect. Covariate analysis was used to identify the source of variability in the population. No significant difference was found between treatments for AUC (P = 0.0645), although AUC was higher in fasted dogs. A significant difference was found for CMAX (P = 0.0059), with fasted dogs attaining a higher CMAX . The covariate of fed versus fasted accounted for a significant variation in the pharmacokinetics. Because feeding was a significant source of variation for the population's primary pharmacokinetic parameters and fasted dogs had higher minocycline concentrations, we recommend administering minocycline without food. © 2015 ESVD and ACVD.

Statistical simplex approach to primary and secondary color correction in thick lens assemblies

NASA Astrophysics Data System (ADS)

Ament, Shelby D. V.; Pfisterer, Richard

2017-11-01

A glass selection optimization algorithm is developed for primary and secondary color correction in thick lens systems. The approach is based on the downhill simplex method, and requires manipulation of the surface color equations to obtain a single glass-dependent parameter for each lens element. Linear correlation is used to relate this parameter to all other glass-dependent variables. The algorithm provides a statistical distribution of Abbe numbers for each element in the system. Examples of several lenses, from 2-element to 6-element systems, are performed to verify this approach. The optimization algorithm proposed is capable of finding glass solutions with high color correction without requiring an exhaustive search of the glass catalog.

Influence of combined dust reducing carpet and compact air filtration unit on the indoor air quality of a classroom.

PubMed

Scheepers, Paul T J; de Hartog, Jeroen J; Reijnaerts, Judith; Beckmann, Gwendolyn; Anzion, Rob; Poels, Katrien; Godderis, Lode

2015-02-01

Primary schools mostly rely on natural ventilation but also have an interest in affordable technology to improve indoor air quality (IAQ). Laboratory tests show promising results for dust reducing carpets and compact air filtration systems but there is no information available on the performance of these interventions in actual operating classrooms. An exploratory study was performed to evaluate a combination of the two systems in a primary school. Measurements of PM-10 and PM-2.5 were performed by filter sampling and aerosol spectrometry. Other IAQ parameters included black smoke (BS), volatile organic compounds (VOC), nitrogen dioxide (NO2) and formaldehyde. Both interventions were introduced in one classroom during one week, using another classroom as a reference. In a second week the interventions were moved to the other classroom, using the first as a reference (cross-over design). In three remaining weeks the classrooms were compared without interventions. Indoor IAQ parameters were compared to the corresponding outdoor parameters using the indoor/outdoor (I/O) ratio. When the classrooms were occupied (teaching hours) interventions resulted in 27-43% reductions of PM-10, PM-2.5 and BS values. During the weekends the systems reduced these levels by 51-87%. Evaluations using the change in I/O ratios gave comparable results. Levels of VOC, NO2 and formaldehyde were rather low and a contribution of the interventions to the improvement of these gas phase IAQ parameters was inconclusive.

Detection of Operator Performance Breakdown as an Automation Triggering Mechanism

NASA Technical Reports Server (NTRS)

Yoo, Hyo-Sang; Lee, Paul U.; Landry, Steven J.

2015-01-01

Performance breakdown (PB) has been anecdotally described as a state where the human operator "loses control of context" and "cannot maintain required task performance." Preventing such a decline in performance is critical to assure the safety and reliability of human-integrated systems, and therefore PB could be useful as a point at which automation can be applied to support human performance. However, PB has never been scientifically defined or empirically demonstrated. Moreover, there is no validated objective way of detecting such a state or the transition to that state. The purpose of this work is: 1) to empirically demonstrate a PB state, and 2) to develop an objective way of detecting such a state. This paper defines PB and proposes an objective method for its detection. A human-in-the-loop study was conducted: 1) to demonstrate PB by increasing workload until the subject reported being in a state of PB, and 2) to identify possible parameters of a detection method for objectively identifying the subjectively-reported PB point, and 3) to determine if the parameters are idiosyncratic to an individual/context or are more generally applicable. In the experiment, fifteen participants were asked to manage three concurrent tasks (one primary and two secondary) for 18 minutes. The difficulty of the primary task was manipulated over time to induce PB while the difficulty of the secondary tasks remained static. The participants' task performance data was collected. Three hypotheses were constructed: 1) increasing workload will induce subjectively-identified PB, 2) there exists criteria that identifies the threshold parameters that best matches the subjectively-identified PB point, and 3) the criteria for choosing the threshold parameters is consistent across individuals. The results show that increasing workload can induce subjectively-identified PB, although it might not be generalizable-only 12 out of 15 participants declared PB. The PB detection method based on signal detection analysis was applied to the performance data and the results showed that PB can be identified using the method, particularly when the values of the parameters for the detection method were calibrated individually.

Cost-Effectiveness Analysis of Chemoradiation Therapy Versus Transoral Robotic Surgery for Human Papillomavirus–Associated, Clinical N2 Oropharyngeal Cancer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sher, David J., E-mail: david.sher@utsouthwestern.edu; Fidler, Mary Jo; Tishler, Roy B.

Purpose: To perform a cost-effectiveness analysis of primary chemoradiation therapy (CRT) versus transoral robotic surgery (TORS) for clinical N2, human papillomavirus (HPV)-positive oropharyngeal carcinoma. Methods and Materials: We developed a Markov model to describe the health states after treatment with CRT or TORS, followed by adjuvant radiation therapy or CRT in the presence of high-risk pathology (positive margins or extracapsular extension). Outcomes, toxicities, and costs were extracted from the literature. One-way sensitivity analyses (SA) were performed over a wide range of parameters, as were 2-way SA between the key variables. Probabilistic SA and value of information studies were performed over keymore » parameters. Results: The expected quality-adjusted life years (QALYs)/total costs for CRT and TORS were 7.31/$50,100 and 7.29/$62,200, respectively, so that CRT dominated TORS. In SA, primary CRT was almost always cost-effective up to a societal willingness-to-pay of $200,000/QALY, unless the locoregional recurrence risk after TORS was 30% to 50% lower, at which point it became cost effective at a willingness-to-pay of $50-100,000/QALY. Probabilistic SA confirmed the importance of locoregional recurrence risk, and the value of information in precisely knowing this parameter was more than $7M per year. If the long-term utility after TORS was 0.03 lower than CRT, CRT was cost-effective over nearly any assumption. Conclusions: Under nearly all assumptions, primary CRT was the cost-effective therapy for HPV-associated, clinical N2 OPC. However, in the hypothetical event of a large relative improvement in LRR with surgery and equivalent long-term utilities, primary TORS would become the higher-value treatment, arguing for prospective, comparative study of the 2 paradigms.« less

Thermal Management in Friction-Stir Welding of Precipitation-Hardening Aluminum Alloys

DOE Office of Scientific and Technical Information (OSTI.GOV)

Upadhyay, Piyush; Reynolds, Anthony

2015-05-25

Process design and implementation in FSW is mostly dependent on empirical information gathered through experience. Basic science of friction stir welding and processing can only be complete when fundamental interrelationships between process control parameters and response variables and resulting weld microstructure and properties are established to a reasonable extent. It is known that primary process control parameters like tool rotation and translation rate and forge axis force have complicated and interactive relationships to the process response variables such as peak temperature, time at temperature etc. Of primary influence to the other process response parameters are temperature and its gradient atmore » the deformation and heat affected zones. Through review of pertinent works in the literature and some experimental results from boundary condition work performed in precipitation hardening aluminum alloys this paper will partially elucidate the nature and effects of temperature transients caused by variation of thermal boundaries in Friction Stir Welding.« less

Thermal Management in Friction-Stir Welding of Precipitation-Hardened Aluminum Alloys

NASA Astrophysics Data System (ADS)

Upadhyay, Piyush; Reynolds, Anthony P.

2015-05-01

Process design and implementation in friction-stir welding (FSW) is mostly dependent on empirical information. Basic science of FSW and processing can only be complete when fundamental interrelationships between the process control parameters and response variables and the resulting weld microstructure and properties are established to a reasonable extent. It is known that primary process control parameters such as tool rotation, translation rates, and forge axis force have complicated and interactive relationships to process-response variables such as peak temperature and time at temperature. Of primary influence on the other process-response parameters are temperature and its gradient in the deformation and heat-affected zones. Through a review of pertinent works in the literature and results from boundary condition experiments performed in precipitation-hardening aluminum alloys, this article partially elucidates the nature and effects of temperature transients caused by variation of thermal boundaries in FSW.

Modeling Enclosure Design in Above-Grade Walls

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lstiburek, J.; Ueno, K.; Musunuru, S.

2016-03-01

This report describes the modeling of typical wall assemblies that have performed well historically in various climate zones. The WUFI (Warme und Feuchte instationar) software (Version 5.3) model was used. A library of input data and results are provided. The provided information can be generalized for application to a broad population of houses, within the limits of existing experience. The WUFI software model was calibrated or tuned using wall assemblies with historically successful performance. The primary performance criteria or failure criteria establishing historic performance was moisture content of the exterior sheathing. The primary tuning parameters (simulation inputs) were airflow andmore » specifying appropriate material properties. Rational hygric loads were established based on experience - specifically rain wetting and interior moisture (RH levels). The tuning parameters were limited or bounded by published data or experience. The WUFI templates provided with this report supply useful information resources to new or less-experienced users. The files present various custom settings that will help avoid results that will require overly conservative enclosure assemblies. Overall, better material data, consistent initial assumptions, and consistent inputs among practitioners will improve the quality of WUFI modeling, and improve the level of sophistication in the field.« less

Pig Spermatozoa Defect in Acrosome Formation Caused Poor Motion Parameters and Fertilization Failure through Artificial Insemination and In vitro Fertilization.

PubMed

Lee, Won Young; Lee, Ran; Kim, Hee Chan; Lee, Kyung Hoon; Cui, Xiang Shun; Kim, Nam Hyung; Kim, Sang Hyun; Lee, Il Joo; Uhm, Sang Jun; Yoon, Min Jung; Song, Hyuk

2014-10-01

The selection of morphologically normal spermatozoa is critical to obtain high breeding performances in boar breeding farms and artificial insemination (AI) centers. Parameters for the selection of semen mainly include total sperm motility, concentration, and morphology. However, these primary parameters are often not reliable for discriminating between normal and abnormal, non-fertilizable spermatozoa. The present study was designed to compare the motion characteristics, fertilization ability using in vitro fertilization (IVF), and acrosome formation of the semen from boars having low (boar number 2012) and normal (boar number 2004 and 2023) breeding performances. The ultimate goal was to identify additional simple and easy criteria for the selection of normal sperm. There was no significant difference between boar 2004 and boar 2023 sperm total motility in computer assisted sperm analysis. However, boar number 2012 semen presented a significantly reduced population of rapid moving spermatozoa and an increased population of slow moving spermatozoa compared to boar numbers 2004 and 2023. Analysis of detailed motion characteristics revealed that sperm from boar number 2012 had significantly reduced motility in progressiveness, average path velocity, straight-line velocity (VSL), curvilinear velocity (VCL), straightness, and linearity. The assessment of the fertilizing ability by IVF also showed that sperm from boar number 2012 showed a fertility rate of 3.4%, whereas sperm from boar number 2023 had a fertility rate of 75.45%. Interestingly, most of the sperm nuclei were found on the peripheral area of the oocytes, suggesting that the sperm from boar number 2012 lacked penetration ability into the oocyte zonapellucida. The acrosome formation analysis using Pisum sativum agglutinin staining demonstrated that the sperm from boar number 2012 had a defect in acrosome formation. Consequently, primary parameters for selecting semen before AI such as motility are not sufficient to select normal and fertilizable spermatozoa. In conclusion, the present study suggests that the acrosome staining and detailed motion characteristics such as progressiveness, VCL, and VSL should be included in determining semen quality together with primary parameters for successful AI and high breeding performance in the swine industry.

Pig Spermatozoa Defect in Acrosome Formation Caused Poor Motion Parameters and Fertilization Failure through Artificial Insemination and In vitro Fertilization

PubMed Central

Lee, Won Young; Lee, Ran; Kim, Hee Chan; Lee, Kyung Hoon; Cui, Xiang Shun; Kim, Nam Hyung; Kim, Sang Hyun; Lee, Il Joo; Uhm, Sang Jun; Yoon, Min Jung; Song, Hyuk

2014-01-01

The selection of morphologically normal spermatozoa is critical to obtain high breeding performances in boar breeding farms and artificial insemination (AI) centers. Parameters for the selection of semen mainly include total sperm motility, concentration, and morphology. However, these primary parameters are often not reliable for discriminating between normal and abnormal, non-fertilizable spermatozoa. The present study was designed to compare the motion characteristics, fertilization ability using in vitro fertilization (IVF), and acrosome formation of the semen from boars having low (boar number 2012) and normal (boar number 2004 and 2023) breeding performances. The ultimate goal was to identify additional simple and easy criteria for the selection of normal sperm. There was no significant difference between boar 2004 and boar 2023 sperm total motility in computer assisted sperm analysis. However, boar number 2012 semen presented a significantly reduced population of rapid moving spermatozoa and an increased population of slow moving spermatozoa compared to boar numbers 2004 and 2023. Analysis of detailed motion characteristics revealed that sperm from boar number 2012 had significantly reduced motility in progressiveness, average path velocity, straight-line velocity (VSL), curvilinear velocity (VCL), straightness, and linearity. The assessment of the fertilizing ability by IVF also showed that sperm from boar number 2012 showed a fertility rate of 3.4%, whereas sperm from boar number 2023 had a fertility rate of 75.45%. Interestingly, most of the sperm nuclei were found on the peripheral area of the oocytes, suggesting that the sperm from boar number 2012 lacked penetration ability into the oocyte zonapellucida. The acrosome formation analysis using Pisum sativum agglutinin staining demonstrated that the sperm from boar number 2012 had a defect in acrosome formation. Consequently, primary parameters for selecting semen before AI such as motility are not sufficient to select normal and fertilizable spermatozoa. In conclusion, the present study suggests that the acrosome staining and detailed motion characteristics such as progressiveness, VCL, and VSL should be included in determining semen quality together with primary parameters for successful AI and high breeding performance in the swine industry. PMID:25178293

Functional parameters but not heart rate variability correlate with long-term outcomes in St-elevation myocardial infarction patients treated by primary angioplasty.

PubMed

Compostella, Leonida; Lakusic, Nenad; Russo, Nicola; Setzu, Tiziana; Compostella, Caterina; Vettore, Elia; Isabella, Giambattista; Tarantini, Giuseppe; Iliceto, Sabino; Bellotto, Fabio

2016-12-01

Depressed heart rate variability (HRV) is usually considered a negative long-term prognostic factor after acute myocardial infarction. Anyway, most of the supporting research was conducted before the era of immediate reperfusion by percutaneous coronary intervention (PCI). Main aim of this study was to evaluate if HRV still retains prognostic significance in our era of immediate PCI. Two weeks after STEMI treated by primary PCI, time-domain HRV was assessed from 24-h Holter recordings in 186 patients: markedly depressed HRV (SDNN <70ms or <50ms) was present in 16% and in 5% of cases, respectively; patients with left ventricle ejection fraction (LVEF) <40% presented more often SDNN values in the lowest quartile. Physical performance was also assessed, by 6-minute walk tests (6MWT) and by cardiopulmonary exercise test (CPET). After >2years from infarction, occurrence of major clinical events (MCE) was investigated. Cases with or without MCE did not differ by initial HRV parameters; Kaplan-Meier events-free survival curves were similar between patients with lowest quartile SDNN and the remaining ones (χ 2 0.981, p=0.322). By the contrary, events-free survival was worse if patients walked shorter distances at 6MWT (χ 2 6.435, p=0.011), developed poorer ventilatory efficiency at CPET (χ 2 10.060, p=0.002), or presented LVEF <40% (χ 2 7.085, p=0.008). In primary-PCI STEMI patients, markedly abnormal HRV was found in a small percentage of cases. HRV seems to have lost its prognostic significance, while parameters indicating LV function (LVEF and physical performance) could allow better prognostication in primary-PCI STEMI patients. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Sequential Gaussian co-simulation of rate decline parameters of longwall gob gas ventholes.

PubMed

Karacan, C Özgen; Olea, Ricardo A

2013-04-01

Gob gas ventholes (GGVs) are used to control methane inflows into a longwall mining operation by capturing the gas within the overlying fractured strata before it enters the work environment. Using geostatistical co-simulation techniques, this paper maps the parameters of their rate decline behaviors across the study area, a longwall mine in the Northern Appalachian basin. Geostatistical gas-in-place (GIP) simulations were performed, using data from 64 exploration boreholes, and GIP data were mapped within the fractured zone of the study area. In addition, methane flowrates monitored from 10 GGVs were analyzed using decline curve analyses (DCA) techniques to determine parameters of decline rates. Surface elevation showed the most influence on methane production from GGVs and thus was used to investigate its relation with DCA parameters using correlation techniques on normal-scored data. Geostatistical analysis was pursued using sequential Gaussian co-simulation with surface elevation as the secondary variable and with DCA parameters as the primary variables. The primary DCA variables were effective percentage decline rate, rate at production start, rate at the beginning of forecast period, and production end duration. Co-simulation results were presented to visualize decline parameters at an area-wide scale. Wells located at lower elevations, i.e., at the bottom of valleys, tend to perform better in terms of their rate declines compared to those at higher elevations. These results were used to calculate drainage radii of GGVs using GIP realizations. The calculated drainage radii are close to ones predicted by pressure transient tests.

Sequential Gaussian co-simulation of rate decline parameters of longwall gob gas ventholes

USGS Publications Warehouse

Karacan, C. Özgen; Olea, Ricardo A.

2013-01-01

Gob gas ventholes (GGVs) are used to control methane inflows into a longwall mining operation by capturing the gas within the overlying fractured strata before it enters the work environment. Using geostatistical co-simulation techniques, this paper maps the parameters of their rate decline behaviors across the study area, a longwall mine in the Northern Appalachian basin. Geostatistical gas-in-place (GIP) simulations were performed, using data from 64 exploration boreholes, and GIP data were mapped within the fractured zone of the study area. In addition, methane flowrates monitored from 10 GGVs were analyzed using decline curve analyses (DCA) techniques to determine parameters of decline rates. Surface elevation showed the most influence on methane production from GGVs and thus was used to investigate its relation with DCA parameters using correlation techniques on normal-scored data. Geostatistical analysis was pursued using sequential Gaussian co-simulation with surface elevation as the secondary variable and with DCA parameters as the primary variables. The primary DCA variables were effective percentage decline rate, rate at production start, rate at the beginning of forecast period, and production end duration. Co-simulation results were presented to visualize decline parameters at an area-wide scale. Wells located at lower elevations, i.e., at the bottom of valleys, tend to perform better in terms of their rate declines compared to those at higher elevations. These results were used to calculate drainage radii of GGVs using GIP realizations. The calculated drainage radii are close to ones predicted by pressure transient tests.

Sequential Gaussian co-simulation of rate decline parameters of longwall gob gas ventholes

PubMed Central

Karacan, C.Özgen; Olea, Ricardo A.

2015-01-01

Gob gas ventholes (GGVs) are used to control methane inflows into a longwall mining operation by capturing the gas within the overlying fractured strata before it enters the work environment. Using geostatistical co-simulation techniques, this paper maps the parameters of their rate decline behaviors across the study area, a longwall mine in the Northern Appalachian basin. Geostatistical gas-in-place (GIP) simulations were performed, using data from 64 exploration boreholes, and GIP data were mapped within the fractured zone of the study area. In addition, methane flowrates monitored from 10 GGVs were analyzed using decline curve analyses (DCA) techniques to determine parameters of decline rates. Surface elevation showed the most influence on methane production from GGVs and thus was used to investigate its relation with DCA parameters using correlation techniques on normal-scored data. Geostatistical analysis was pursued using sequential Gaussian co-simulation with surface elevation as the secondary variable and with DCA parameters as the primary variables. The primary DCA variables were effective percentage decline rate, rate at production start, rate at the beginning of forecast period, and production end duration. Co-simulation results were presented to visualize decline parameters at an area-wide scale. Wells located at lower elevations, i.e., at the bottom of valleys, tend to perform better in terms of their rate declines compared to those at higher elevations. These results were used to calculate drainage radii of GGVs using GIP realizations. The calculated drainage radii are close to ones predicted by pressure transient tests. PMID:26190930

Considerations for performance evaluation of solar heating and cooling systems

NASA Technical Reports Server (NTRS)

Littles, J. W.; Cody, J. C.

1975-01-01

One of the many factors which must be considered in performance evaluation of solar energy systems is the relative merit of a given solar energy system when compared to a standard conventional system. Although initial and operational costs will be dominant factors in the comparison of the two types of systems and will be given prime consideration in system selection, sufficient data are not yet available for a definitive treatment of these variables. It is possible, however, to formulate relationships between the nonsolar energy requirements of the solar energy systems and the energy requirements of a conventional system in terms of the primary performance parameters of the systems. Derivations of such relationships, some parametric data for selected ranges of the performance parameters, and data with respect to limiting conditions are presented.

Parameters affecting mechanical and thermal responses in bone drilling: A review.

PubMed

Lee, JuEun; Chavez, Craig L; Park, Joorok

2018-04-11

Surgical bone drilling is performed variously to correct bone fractures, install prosthetics, or for therapeutic treatment. The primary concern in bone drilling is to extract donor bone sections and create receiving holes without damaging the bone tissue either mechanically or thermally. We review current results from experimental and theoretical studies to investigate the parameters related to such effects. This leads to a comprehensive understanding of the mechanical and thermal aspects of bone drilling to reduce their unwanted complications. This review examines the important bone-drilling parameters of bone structure, drill-bit geometry, operating conditions, and material evacuation, and considers the current techniques used in bone drilling. We then analyze the associated mechanical and thermal effects and their contributions to bone-drilling performance. In this review, we identify a favorable range for each parameter to reduce unwanted complications due to mechanical or thermal effects. Copyright © 2018 Elsevier Ltd. All rights reserved.

Distinct iris gene expression profiles of primary angle closure glaucoma and primary open angle glaucoma and their interaction with ocular biometric parameters.

PubMed

Seet, Li-Fong; Narayanaswamy, Arun; Finger, Sharon N; Htoon, Hla M; Nongpiur, Monisha E; Toh, Li Zhen; Ho, Henrietta; Perera, Shamira A; Wong, Tina T

2016-11-01

This study aimed to evaluate differences in iris gene expression profiles between primary angle closure glaucoma (PACG) and primary open angle glaucoma (POAG) and their interaction with biometric characteristics. Prospective study. Thirty-five subjects with PACG and thirty-three subjects with POAG who required trabeculectomy were enrolled at the Singapore National Eye Centre, Singapore. Iris specimens, obtained by iridectomy, were analysed by real-time polymerase chain reaction for expression of type I collagen, vascular endothelial growth factor (VEGF)-A, -B and -C, as well as VEGF receptors (VEGFRs) 1 and 2. Anterior segment optical coherence tomography (ASOCT) imaging for biometric parameters, including anterior chamber depth (ACD), anterior chamber volume (ACV) and lens vault (LV), was also performed pre-operatively. Relative mRNA levels between PACG and POAG irises, biometric measurements, discriminant analyses using genes and biometric parameters. COL1A1, VEGFB, VEGFC and VEGFR2 mRNA expression was higher in PACG compared to POAG irises. LV, ACD and ACV were significantly different between the two subgroups. Discriminant analyses based on gene expression, biometric parameters or a combination of both gene expression and biometrics (LV and ACV), correctly classified 94.1%, 85.3% and 94.1% of the original PACG and POAG cases, respectively. The discriminant function combining genes and biometrics demonstrated the highest accuracy in cross-validated classification of the two glaucoma subtypes. Distinct iris gene expression supports the pathophysiological differences that exist between PACG and POAG. Biometric parameters can combine with iris gene expression to more accurately define PACG from POAG. © 2016 The Authors. Clinical & Experimental Ophthalmology published by John Wiley & Sons Australia, Ltd on behalf of Royal Australian and New Zealand College of Ophthalmologists.

Dynamic Contrast-enhanced Magnetic Resonance Imaging for Differentiating Between Primary Tumor, Metastatic Node and Normal Tissue in Head and Neck Cancer.

PubMed

Chen, Liangliang; Ye, Yufeng; Chen, Hanwei; Chen, Shihui; Jiang, Jinzhao; Dan, Guo; Huang, Bingsheng

2018-06-01

To study the difference of the Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) parameters among the primary tumor, metastatic node and peripheral normal tissue of head and neck cancer. Consecutive newly-diagnosed head and neck cancer patients with nodal metastasis between December 2010 and July 2013 were recruited, and 25 patients (8 females; 24~63,mean 43±11 years old) were enrolled. DCE-MRI was performed in the primary tumor region including the regional lymph nodes on a 3.0-T MRI system. Three quantitative parameters: Ktrans (volume transfer constant), ve (volume fraction of extravascular extracellular space) and kep (the rate constant of contrast transfer) were calculated for the largest node. A repeated-measure ANOVA with a Greenhouse-Geisser correction and post hoc tests using the Bonferroni correction were used to evaluate the differences in Ktrans, ve and kep among primary tumors, metastatic nodes and normal tissue. The values of both Ktrans and ve of normal tissue differed significantly from those of nodes (both P < 0.001) and primary tumors (both P < 0.001) respectively, while no significant differences of Ktrans and ve were observed between nodes and primary tumors (P = 0.075 and 0.365 respectively). The kep values of primary tumors were significantly different from those of nodes (P = 0.001) and normal tissue (P = 0.002), while no significant differences between nodes and normal tissue (P > 0.999). The DCE-MRI parameters were different in the tumors, metastatic nodes and normal tissue in head and neck cancer. These findings may be useful in the characterization of head and neck cancer.

Office spirometry in primary care pediatrics: a pilot study.

PubMed

Zanconato, Stefania; Meneghelli, Giorgio; Braga, Raffaele; Zacchello, Franco; Baraldi, Eugenio

2005-12-01

The aim of this study was to investigate the validity of office spirometry in primary care pediatric practices. Ten primary care pediatricians undertook a spirometry training program that was led by 2 pediatric pulmonologists from the Pediatric Department of the University of Padova. After the pediatricians' training, children with asthma or persistent cough underwent a spirometric test in the pediatrician's office and at a pulmonary function (PF) laboratory, in the same day in random order. Both spirometric tests were performed with a portable turbine flow sensor spirometer. We assessed the quality of the spirometric tests and compared a range of PF parameters obtained in the pediatricians' offices and in the PF laboratory according to the Bland and Altman method. A total of 109 children (mean age: 10.4 years; range: 6-15) were included in the study. Eighty-five (78%) of the spirometric tests that were performed in the pediatricians' offices met all of the acceptability and reproducibility criteria. The 24 unacceptable test results were attributable largely to a slow start and failure to satisfy end-of-test criteria. Only the 85 acceptable spirometric tests were considered for analysis. The agreement between the spirometric tests that were performed in the pediatrician's office and in the PF laboratory was good for the key parameters (forced vital capacity, forced expiratory volume in 1 second, and forced expiratory flow between 25% and 75%). The repeatability coefficient was 0.26 L for forced expiratory volume in 1 second (83 of 85 values fall within this range), 0.30 L for forced vital capacity (81 values fall within this range), and 0.58 L/s for forced expiratory flow between 25% and 75% (82 values fall within this range). In 79% of cases, the primary care pediatricians interpreted the spirometric tests correctly. It seems justifiable to perform spirometry in pediatric primary care, but an integrated approach involving both the primary care pediatrician and certified pediatric respiratory medicine centers is recommended because effective training and quality assurance are vital prerequisites for successful spirometry.

Multivariable Parametric Cost Model for Ground Optical Telescope Assembly

NASA Technical Reports Server (NTRS)

Stahl, H. Philip; Rowell, Ginger Holmes; Reese, Gayle; Byberg, Alicia

2005-01-01

A parametric cost model for ground-based telescopes is developed using multivariable statistical analysis of both engineering and performance parameters. While diameter continues to be the dominant cost driver, diffraction-limited wavelength is found to be a secondary driver. Other parameters such as radius of curvature are examined. The model includes an explicit factor for primary mirror segmentation and/or duplication (i.e., multi-telescope phased-array systems). Additionally, single variable models Based on aperture diameter are derived.

Projectile fragmentation of 40,48Ca and isotopic scaling in a transport approach

NASA Astrophysics Data System (ADS)

Mikhailova, T. I.; Erdemchimeg, B.; Artukh, A. G.; Di Toro, M.; Wolter, H. H.

2016-07-01

We investigate theoretically projectile fragmentation in reactions of 40,48Ca on 9Be and 181Ta targets using a Boltzmann-type transport approach, which is supplemented by a statistical decay code to describe the de-excitation of the hot primary fragments. We determine the thermodynamical properties of the primary fragments and calculate the isotope distributions of the cold final fragments. These describe the data reasonably well. For the pairs of projectiles with different isotopic content we analyze the isotopic scaling (or isoscaling) of the final fragment distributions, which has been used to extract the symmetry energy of the primary source. The calculation exhibits isoscaling behavior for the total yields as do the experiments. We also perform an impact-parameter-dependent isoscaling analysis in view of the fact that the primary systems at different impact parameters have very different properties. Then the isoscaling behavior is less stringent, which we can attribute to specific structure effects of the 40,48Ca pair. The symmetry energy determined in this way depends on these structure effects.

Projectile fragmentation of {sup 40,48}Ca and isotopic scaling in a transport approach

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mikhailova, T. I., E-mail: tmikh@jinr.ru; Erdemchimeg, B.; Artukh, A. G.

2016-07-15

We investigate theoretically projectile fragmentation in reactions of {sup 40,48}Ca on {sup 9}Be and {sup 181}Ta targets using a Boltzmann-type transport approach, which is supplemented by a statistical decay code to describe the de-excitation of the hot primary fragments. We determine the thermodynamical properties of the primary fragments and calculate the isotope distributions of the cold final fragments. These describe the data reasonably well. For the pairs of projectiles with different isotopic content we analyze the isotopic scaling (or isoscaling) of the final fragment distributions, which has been used to extract the symmetry energy of the primary source. The calculationmore » exhibits isoscaling behavior for the total yields as do the experiments. We also perform an impact-parameter-dependent isoscaling analysis in view of the fact that the primary systems at different impact parameters have very different properties. Then the isoscaling behavior is less stringent, which we can attribute to specific structure effects of the {sup 40,48}Ca pair. The symmetry energy determined in this way depends on these structure effects.« less

Monitoring of in-service geosynthetic reinforced soil (GRS) bridge abutments in Louisiana : research project capsule.

DOT National Transportation Integrated Search

2014-09-01

The primary objectives of this research are to monitor the : short-term and long-term behavior and performance of inservice : GRS-IBS abutments in the state of Louisiana, and to : verify important design factors and parameters for GRS-IBS : abutment,...

Landsat-5 bumper-mode geometric correction

USGS Publications Warehouse

Storey, James C.; Choate, Michael J.

2004-01-01

The Landsat-5 Thematic Mapper (TM) scan mirror was switched from its primary operating mode to a backup mode in early 2002 in order to overcome internal synchronization problems arising from long-term wear of the scan mirror mechanism. The backup bumper mode of operation removes the constraints on scan start and stop angles enforced in the primary scan angle monitor operating mode, requiring additional geometric calibration effort to monitor the active scan angles. It also eliminates scan timing telemetry used to correct the TM scan geometry. These differences require changes to the geometric correction algorithms used to process TM data. A mathematical model of the scan mirror's behavior when operating in bumper mode was developed. This model includes a set of key timing parameters that characterize the time-varying behavior of the scan mirror bumpers. To simplify the implementation of the bumper-mode model, the bumper timing parameters were recast in terms of the calibration and telemetry data items used to process normal TM imagery. The resulting geometric performance, evaluated over 18 months of bumper-mode operations, though slightly reduced from that achievable in the primary operating mode, is still within the Landsat specifications when the data are processed with the most up-to-date calibration parameters.

Effects of Retinal Eccentricity on Human Manual Control

NASA Technical Reports Server (NTRS)

Popovici, Alexandru; Zaal, Peter M. T.

2017-01-01

This study investigated the effects of viewing a primary flight display at different retinal eccentricities on human manual control behavior and performance. Ten participants performed a pitch tracking task while looking at a simplified primary flight display at different horizontal and vertical retinal eccentricities, and with two different controlled dynamics. Tracking performance declined at higher eccentricity angles and participants behaved more nonlinearly. The visual error rate gain increased with eccentricity for single-integrator-like controlled dynamics, but decreased for double-integrator-like dynamics. Participants' visual time delay was up to 100 ms higher at the highest horizontal eccentricity compared to foveal viewing. Overall, vertical eccentricity had a larger impact than horizontal eccentricity on most of the human manual control parameters and performance. Results might be useful in the design of displays and procedures for critical flight conditions such as in an aerodynamic stall.

Characterization and Design of Spiral Frequency Steerable Acoustic Transducers

NASA Astrophysics Data System (ADS)

Repale, Rohan

Structural Health Monitoring (SHM) is an emerging research area devoted to improving the safety and maintainability of civil structures. Guided wave structural testing method is an effective approach used for SHM of plate-like structures using piezoelectric transducers. These transducers are attached to the surface of the structure and are capable of sensing its health by using surface waves. Transducers with beam steering i.e. electronic scanning capabilities can perform surface interrogation with higher precision and ease. A frequency steerable acoustic transducer (FSAT) is capable of beam steering and directional surface wave sensing to detect and localize damage in structures. The objective of this research is to further explore the possibilities of FSAT technology by designing and testing new FSAT designs. The beam steering capability of FSAT can be controlled by manipulating its design parameters. These design parameters therefore play a significant role in FSAT's performance. Studying the design parameters and documenting the performance improvements based on parameter variation is the primary goal of this research. Design and characterization of spiral FSAT was performed and results were simulated. Array FSAT documented results were validated. Modified designs were modeled based on design parameter variations. Characterization of these designs was done and their performance was recorded. Plate simulation results confirm direct relationship between design parameters and beam steering. A set of guidelines for future designs was also proposed. Two designs developed based on the set guidelines were sent to our collaborator Genziko Inc. for fabrication.

Use of an approximate similarity principle for the thermal scaling of a full-scale thrust augmenting ejector

NASA Technical Reports Server (NTRS)

Barankiewicz, Wendy; Perusek, Gail P.; Ibrahim, Mounir

1992-01-01

Full temperature ejector model simulations are expensive, and difficult to implement experimentally. If an approximate similarity principle could be established, properly chosen performance parameters should be similar for both hot and cold flow tests if the initial Mach number and total pressures of the flow field are held constant. Existing ejector data is used to explore the utility of one particular similarity principle; the Munk and Prim similarity principle for isentropic flows. Static performance test data for a full-scale thrust augmenting ejector are analyzed for primary flow temperatures up to 1560 R. At different primary temperatures, exit pressure contours are compared for similarity. A nondimensional flow paramenter is then used to eliminate primary nozzle temperature dependence and verify similarity between the hot and cold flow experiments.

ωB97X-V: A 10-parameter, range-separated hybrid, generalized gradient approximation density functional with nonlocal correlation, designed by a survival-of-the-fittest strategy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mardirossian, Narbe; Head-Gordon, Martin

2013-12-18

A 10-parameter, range-separated hybrid (RSH), generalized gradient approximation (GGA) density functional with nonlocal correlation (VV10) is presented in this paper. Instead of truncating the B97-type power series inhomogeneity correction factors (ICF) for the exchange, same-spin correlation, and opposite-spin correlation functionals uniformly, all 16 383 combinations of the linear parameters up to fourth order (m = 4) are considered. These functionals are individually fit to a training set and the resulting parameters are validated on a primary test set in order to identify the 3 optimal ICF expansions. Through this procedure, it is discovered that the functional that performs best onmore » the training and primary test sets has 7 linear parameters, with 3 additional nonlinear parameters from range-separation and nonlocal correlation. The resulting density functional, ωB97X-V, is further assessed on a secondary test set, the parallel-displaced coronene dimer, as well as several geometry datasets. Finally and furthermore, the basis set dependence and integration grid sensitivity of ωB97X-V are analyzed and documented in order to facilitate the use of the functional.« less

Driving Performance Under Alcohol in Simulated Representative Driving Tasks

PubMed Central

Kenntner-Mabiala, Ramona; Kaussner, Yvonne; Jagiellowicz-Kaufmann, Monika; Hoffmann, Sonja; Krüger, Hans-Peter

2015-01-01

Abstract Comparing drug-induced driving impairments with the effects of benchmark blood alcohol concentrations (BACs) is an approved approach to determine the clinical relevance of findings for traffic safety. The present study aimed to collect alcohol calibration data to validate findings of clinical trials that were derived from a representative test course in a dynamic driving simulator. The driving performance of 24 healthy volunteers under placebo and with 0.05% and 0.08% BACs was measured in a double-blind, randomized, crossover design. Trained investigators assessed the subjects’ driving performance and registered their driving errors. Various driving parameters that were recorded during the simulation were also analyzed. Generally, the participants performed worse on the test course (P < 0.05 for the investigators’ assessment) under the influence of alcohol. Consistent with the relevant literature, lane-keeping performance parameters were sensitive to the investigated BACs. There were significant differences between the alcohol and placebo conditions in most of the parameters analyzed. However, the total number of errors was the only parameter discriminating significantly between all three BAC conditions. In conclusion, data show that the present experimental setup is suitable for future psychopharmacological research. Thereby, for each drug to be investigated, we recommend to assess a profile of various parameters that address different levels of driving. On the basis of this performance profile, the total number of driving errors is recommended as the primary endpoint. However, this overall endpoint should be completed by a specifically sensitive parameter that is chosen depending on the effect known to be induced by the tested drug. PMID:25689289

Comparative study of the retinal nerve fibre layer thickness performed with optical coherence tomography and GDx scanning laser polarimetry in patients with primary open-angle glaucoma.

PubMed

Wasyluk, Jaromir T; Jankowska-Lech, Irmina; Terelak-Borys, Barbara; Grabska-Liberek, Iwona

2012-03-01

We compared the parameters of retinal nerve fibre layer in patients with advanced glaucoma with the use of different OCT (Optical Coherence Tomograph) devices in relation to analogical measurements performed with GDx VCC (Nerve Fiber Analyzer with Variable Corneal Compensation) scanning laser polarimetry. Study subjects had advanced primary open-angle glaucoma, previously treated conservatively, diagnosed and confirmed by additional examinations (visual field, ophthalmoscopy of optic nerve, gonioscopy), A total of 10 patients were enrolled (9 women and 1 man), aged 18-70 years of age. Nineteen eyes with advanced glaucomatous neuropathy were examined. 1) Performing a threshold perimetry Octopus, G2 strategy and ophthalmoscopy of optic nerve to confirm the presence of advanced primary open-angle glaucoma; 2) performing a GDx VCC scanning laser polarimetry of retinal nerve fibre layer; 3) measuring the retinal nerve fibre layer thickness with 3 different optical coherence tomographs. The parameters of the retinal nerve fibre layer thickness are highly correlated between the GDx and OCT Stratus and 3D OCT-1000 devices in mean retinal nerve fibre layer thickness, retinal nerve fibre layer thickness in the upper sector, and correlation of NFI (GDx) with mean retinal nerve fibre layer thickness in OCT examinations. Absolute values of the retinal nerve fibre layer thickness (measured in µm) differ significantly between GDx and all OCT devices. Examination with OCT devices is a sensitive diagnostic method of glaucoma, with good correlation with the results of GDx scanning laser polarimetry of the patients.

Multivariable Parametric Cost Model for Ground Optical: Telescope Assembly

NASA Technical Reports Server (NTRS)

Stahl, H. Philip; Rowell, Ginger Holmes; Reese, Gayle; Byberg, Alicia

2004-01-01

A parametric cost model for ground-based telescopes is developed using multi-variable statistical analysis of both engineering and performance parameters. While diameter continues to be the dominant cost driver, diffraction limited wavelength is found to be a secondary driver. Other parameters such as radius of curvature were examined. The model includes an explicit factor for primary mirror segmentation and/or duplication (i.e. multi-telescope phased-array systems). Additionally, single variable models based on aperture diameter were derived.

Correlation between quantitative and semiquantitative parameters in DCE-MRI with a blood pool agent in rectal cancer: can semiquantitative parameters be used as a surrogate for quantitative parameters?

PubMed

Dijkhoff, Rebecca A P; Maas, Monique; Martens, Milou H; Papanikolaou, Nikolaos; Lambregts, Doenja M J; Beets, Geerard L; Beets-Tan, Regina G H

2017-05-01

The aim of this study was to assess correlation between quantitative and semiquantitative parameters in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in rectal cancer patients, both in a primary staging and restaging setting. Nineteen patients were included with DCE-MRI before and/or after neoadjuvant therapy. DCE-MRI was performed with gadofosveset trisodium (Ablavar ® , Lantheus Medical Imaging, North Billerica, Massachusetts, USA). Regions of interest were placed in the tumor and quantitative parameters were extracted with Olea Sphere 2.2 software permeability module using the extended Tofts model. Semiquantitative parameters were calculated on a pixel-by-pixel basis. Spearman rank correlation tests were used for assessment of correlation between parameters. A p value ≤0.05 was considered statistically significant. Strong positive correlations were found between mean peak enhancement and mean K trans : 0.79 (all patients, p<0.0001), 0.83 (primary staging, p = 0.003), and 0.81 (restaging, p = 0.054). Mean wash-in correlated significantly with mean V p and K ep (0.79 and 0.58, respectively, p<0.0001 and p = 0.009) in all patients. Mean wash-in showed a significant correlation with mean K ep (0.67, p = 0.033) in the primary staging group. On the restaging MRI, mean wash-in only strongly correlated with mean V p (0.81, p = 0.054). This study shows a strong correlation between quantitative and semiquantitative parameters in DCE-MRI for rectal cancer. Peak enhancement correlates strongly with K trans and wash-in showed strong correlation with V p and K ep . These parameters have been reported to predict tumor aggressiveness and response in rectal cancer. Therefore, semiquantitative analyses might be a surrogate for quantitative analyses.

High-energy laser weapons: technology overview

NASA Astrophysics Data System (ADS)

Perram, Glen P.; Marciniak, Michael A.; Goda, Matthew

2004-09-01

High energy laser (HEL) weapons are ready for some of today"s most challenging military applications. For example, the Airborne Laser (ABL) program is designed to defend against Theater Ballistic Missiles in a tactical war scenario. Similarly, the Tactical High Energy Laser (THEL) program is currently testing a laser to defend against rockets and other tactical weapons. The Space Based Laser (SBL), Advanced Tactical Laser (ATL) and Large Aircraft Infrared Countermeasures (LAIRCM) programs promise even greater applications for laser weapons. This technology overview addresses both strategic and tactical roles for HEL weapons on the modern battlefield and examines current technology limited performance of weapon systems components, including various laser device types, beam control systems, atmospheric propagation, and target lethality issues. The characteristics, history, basic hardware, and fundamental performance of chemical lasers, solid state lasers and free electron lasers are summarized and compared. The elements of beam control, including the primary aperture, fast steering mirror, deformable mirrors, wavefront sensors, beacons and illuminators will be discussed with an emphasis on typical and required performance parameters. The effects of diffraction, atmospheric absorption, scattering, turbulence and thermal blooming phenomenon on irradiance at the target are described. Finally, lethality criteria and measures of weapon effectiveness are addressed. The primary purpose of the presentation is to define terminology, establish key performance parameters, and summarize technology capabilities.

Relationships Between Solidification Parameters in A319 Aluminum Alloy

NASA Astrophysics Data System (ADS)

Vandersluis, E.; Ravindran, C.

2018-03-01

The design of high-performance materials depends on a comprehensive understanding of the alloy-specific relationships between solidification and properties. However, the inconsistent use of a particular solidification parameter for presenting materials characterization in the literature impedes inter-study comparability and the interpretation of findings. Therefore, there is a need for accurate expressions relating the solidification parameters for each alloy. In this study, A319 aluminum alloy castings were produced in a permanent mold with various preheating temperatures in order to control metal cooling. Analysis of the cooling curve for each casting enabled the identification of its liquidus, Al-Si eutectic, and solidus temperatures and times. These values led to the calculation of the primary solidification rate, total solidification rate, primary solidification time, and local solidification time for each casting, which were related to each other as well as to the average casting SDAS and material hardness. Expressions for each of their correlations have been presented with high coefficients of determination, which will aid in microstructural prediction and casting design.

Stability of omega-3 LC-PUFA-rich photoautotrophic microalgal oils compared to commercially available omega-3 LC-PUFA oils.

PubMed

Ryckebosch, Eline; Bruneel, Charlotte; Termote-Verhalle, Romina; Lemahieu, Charlotte; Muylaert, Koenraad; Van Durme, Jim; Goiris, Koen; Foubert, Imogen

2013-10-23

Microalgae are the primary producers of omega-3 LC-PUFA, which are known for their health benefits. Their oil may thus be a potential alternative for fish oil. However, oxidative and hydrolytic stability of omega-3 LC-PUFA oils are important parameters. The purpose of this work was therefore to evaluate these parameters in oils from photoautotrophic microalgae (Isochrysis, Phaeodactylum, Nannochloropsis gaditana, and Nannochloropsis sp.) obtained with hexane/isopropanol (HI) and hexane (H) and compare them with commercial omega-3 LC-PUFA oils. When the results of both the primary and secondary oxidation parameters were put together, it was clear that fish, tuna, and heterotrophic microalgae oil are the least oxidatively stable oils, whereas krill oil and the microalgae oils performed better. The microalgal HI oils were shown to be more oxidatively stable than the microalgal H oils. The hydrolytic stability was shown not to be a problem during the storage of any of the oils.

Tack Measurements of Prepreg Tape at Variable Temperature and Humidity

NASA Technical Reports Server (NTRS)

Wohl, Christopher; Palmieri, Frank L.; Forghani, Alireza; Hickmott, Curtis; Bedayat, Houman; Coxon, Brian; Poursartip, Anoush; Grimsley, Brian

2017-01-01

NASA’s Advanced Composites Project has established the goal of achieving a 30 percent reduction in the timeline for certification of primary composite structures for application on commercial aircraft. Prepreg tack is one of several critical parameters affecting composite manufacturing by automated fiber placement (AFP). Tack plays a central role in the prevention of wrinkles and puckers that can occur during AFP, thus knowledge of tack variation arising from a myriad of manufacturing and environmental conditions is imperative for the prediction of defects during AFP. A full design of experiments was performed to experimentally characterize tack on 0.25-inch slit-tape tow IM7/8552-1 prepreg using probe tack testing. Several process parameters (contact force, contact time, retraction speed, and probe diameter) as well as environmental parameters (temperature and humidity) were varied such that the entire parameter space could be efficiently evaluated. Mid-point experimental conditions (i.e., parameters not at either extrema) were included to enable prediction of curvature in relationships and repeat measurements were performed to characterize experimental error. Collectively, these experiments enable determination of primary dependencies as well as multi-parameter relationships. Slit-tape tow samples were mounted to the bottom plate of a rheometer parallel plate fixture using a jig to prevent modification of the active area to be interrogated with the top plate, a polished stainless steel probe, during tack testing. The probe surface was slowly brought into contact with the pre-preg surface until a pre-determined normal force was achieved (2-30 newtons). After a specified dwell time (0.02-10 seconds), during which the probe substrate interaction was maintained under displacement control, the probe was retracted from the surface (0.1-50 millimeters per second). Initial results indicated a clear dependence of tack strength on several parameters, with a particularly strong dependence on temperature and humidity. Although an increase in either of these parameters reduces tack strength, a maximum in tack was predicted to occur under conditions of low temperature and moderate humidity.

Effects of the eccentricity of the primaries in powered Swing-By maneuvers

NASA Astrophysics Data System (ADS)

Ferreira, Alessandra F. S.; Prado, Antônio F. B. A.; Winter, Othon C.; Santos, Denilson P. S.

2017-04-01

The present paper studies the powered Swing-By maneuver when performed in an elliptical system of primaries. It means that there is a spacecraft travelling in a system governed by the gravity fields of two bodies that are in elliptical orbits around their center of mass. The paper particularly analyzes the effects of the parameters relative to the Swing-By (Vinf-,rp, ψ), the orbit of the secondary body around the primary one (e, ν) and the elements that specify the impulse applied (δV, α) to the spacecraft. The impulse is applied when the spacecraft passes by the periapsis of its orbit around the body, where it performs the Swing-By, with different magnitudes and directions. The inclusion of the orbital eccentricity of the primaries in this problem makes it closer to reality, considering that there are many known systems with eccentricities different from zero. In particular, there are several moons in the Solar System which orbits are not circular, as well as some smaller bodies, like the dwarf planet Haumea and its moons, which have eccentricities of 0.25 or even larger. The behavior of the energy variation of the spacecraft is shown in details, as well as the cases where captures and collisions occur. The results show the conditions that optimize this maneuver, according to some given parameters, and how much can be obtained in terms of gains or losses of energy using the best conditions found by the algorithm developed here.

Optimization of the lithium/thionyl chloride battery

NASA Technical Reports Server (NTRS)

White, Ralph E.

1989-01-01

A 1-D math model for the lithium/thionyl chloride primary cell is used in conjunction with a parameter estimation technique in order to estimate the electro-kinetic parameters of this electrochemical system. The electro-kinetic parameters include the anodic transfer coefficient and exchange current density of the lithium oxidation, alpha sub a,1 and i sub o,i,ref, the cathodic transfer coefficient and the effective exchange current density of the thionyl chloride reduction, alpha sub c,2 and a sup o i sub o,2,ref, and a morphology parameter, Xi. The parameter estimation is performed on simulated data first in order to gain confidence in the method. Data, reported in the literature, for a high rate discharge of an experimental lithium/thionyl chloride cell is used for an analysis.

Photosynthesis-irradiance parameters of marine phytoplankton: synthesis of a global data set

NASA Astrophysics Data System (ADS)

Bouman, Heather A.; Platt, Trevor; Doblin, Martina; Figueiras, Francisco G.; Gudmundsson, Kristinn; Gudfinnsson, Hafsteinn G.; Huang, Bangqin; Hickman, Anna; Hiscock, Michael; Jackson, Thomas; Lutz, Vivian A.; Mélin, Frédéric; Rey, Francisco; Pepin, Pierre; Segura, Valeria; Tilstone, Gavin H.; van Dongen-Vogels, Virginie; Sathyendranath, Shubha

2018-02-01

The photosynthetic performance of marine phytoplankton varies in response to a variety of factors, environmental and taxonomic. One of the aims of the MArine primary Production: model Parameters from Space (MAPPS) project of the European Space Agency is to assemble a global database of photosynthesis-irradiance (P-E) parameters from a range of oceanographic regimes as an aid to examining the basin-scale variability in the photophysiological response of marine phytoplankton and to use this information to improve the assignment of P-E parameters in the estimation of global marine primary production using satellite data. The MAPPS P-E database, which consists of over 5000 P-E experiments, provides information on the spatio-temporal variability in the two P-E parameters (the assimilation number, PmB, and the initial slope, αB, where the superscripts B indicate normalisation to concentration of chlorophyll) that are fundamental inputs for models (satellite-based and otherwise) of marine primary production that use chlorophyll as the state variable. Quality-control measures consisted of removing samples with abnormally high parameter values and flags were added to denote whether the spectral quality of the incubator lamp was used to calculate a broad-band value of αB. The MAPPS database provides a photophysiological data set that is unprecedented in number of observations and in spatial coverage. The database will be useful to a variety of research communities, including marine ecologists, biogeochemical modellers, remote-sensing scientists and algal physiologists. The compiled data are available at https://doi.org/10.1594/PANGAEA.874087 (Bouman et al., 2017).

Conceptual design and structural analysis for an 8.4-m telescope

NASA Astrophysics Data System (ADS)

Mendoza, Manuel; Farah, Alejandro; Ruiz Schneider, Elfego

2004-09-01

This paper describes the conceptual design of the optics support structures of a telescope with a primary mirror of 8.4 m, the same size as a Large Binocular Telescope (LBT) primary mirror. The design goal is to achieve a structure for supporting the primary and secondary mirrors and keeping them joined as rigid as possible. With this purpose an optimization with several models was done. This iterative design process includes: specifications development, concepts generation and evaluation. Process included Finite Element Analysis (FEA) as well as other analytical calculations. Quality Function Deployment (QFD) matrix was used to obtain telescope tube and spider specifications. Eight spiders and eleven tubes geometric concepts were proposed. They were compared in decision matrixes using performance indicators and parameters. Tubes and spiders went under an iterative optimization process. The best tubes and spiders concepts were assembled together. All assemblies were compared and ranked according to their performance.

Does resident ranking during recruitment accurately predict subsequent performance as a surgical resident?

PubMed

Fryer, Jonathan P; Corcoran, Noreen; George, Brian; Wang, Ed; Darosa, Debra

2012-01-01

While the primary goal of ranking applicants for surgical residency training positions is to identify the candidates who will subsequently perform best as surgical residents, the effectiveness of the ranking process has not been adequately studied. We evaluated our general surgery resident recruitment process between 2001 and 2011 inclusive, to determine if our recruitment ranking parameters effectively predicted subsequent resident performance. We identified 3 candidate ranking parameters (United States Medical Licensing Examination [USMLE] Step 1 score, unadjusted ranking score [URS], and final adjusted ranking [FAR]), and 4 resident performance parameters (American Board of Surgery In-Training Examination [ABSITE] score, PGY1 resident evaluation grade [REG], overall REG, and independent faculty rating ranking [IFRR]), and assessed whether the former were predictive of the latter. Analyses utilized Spearman correlation coefficient. We found that the URS, which is based on objective and criterion based parameters, was a better predictor of subsequent performance than the FAR, which is a modification of the URS based on subsequent determinations of the resident selection committee. USMLE score was a reliable predictor of ABSITE scores only. However, when we compared our worst residence performances with the performances of the other residents in this evaluation, the data did not produce convincing evidence that poor resident performances could be reliably predicted by any of the recruitment ranking parameters. Finally, stratifying candidates based on their rank range did not effectively define a ranking cut-off beyond which resident performance would drop off. Based on these findings, we recommend surgery programs may be better served by utilizing a more structured resident ranking process and that subsequent adjustments to the rank list generated by this process should be undertaken with caution. Copyright © 2012 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

Pharmacodynamics of temazepam in primary insomnia: assessment of the value of quantitative electroencephalography and saccadic eye movements in predicting improvement of sleep.

PubMed

Tuk, B; Oberyé, J J; Pieters, M S; Schoemaker, R C; Kemp, B; van Gerven, J; Danhof, M; Kamphuisen, H A; Cohen, A F; Breimer, D D; Peck, C C

1997-10-01

Quantitative electroencephalographic parameters and saccadic eye movements are frequently used as pharmacodynamic measures of benzodiazepine effect. We investigated the relationship between these measures and the hypnotic effect. The correlation between the pharmacodynamic measures and sleep quality was determined in 21 patients with primary insomnia. The pharmacokinetic-pharmacodynamic relationships were characterized after administration of 20 mg oral temazepam. The hypnotic effect was determined on the basis of polysomnographic sleep recordings and a subjective sleep evaluation questionnaire. Correlations between pharmacodynamic measures and the improvement of sleep were investigated. The pharmacokinetic-pharmacodynamic relationships for the parameters derived from electroencephalography and saccadic eye movements showed considerable interindividual variability. Administration of temazepam led to a significant improvement in the objective parameters sleep period efficiency, wake time after sleep onset, and sleep efficiency and in the subjective assessment of sleep quality. No significant correlations were observed between the pharmacokinetic-pharmacodynamic-derived parameters and the improvement in objective or subjective sleep parameters. In subjects with primary insomnia the administration of 20 mg oral temazepam results in changes in both the pharmacodynamic measures and in quality of sleep. No individual correlations between the pharmacodynamic measures and quality of sleep were observed. We concluded that the investigated pharmacodynamic measures are of value in the first assessment of clinical efficacy and for the selection of the dose(s) to be investigated in subsequent trials that aim at showing clinical efficacy. However, the conclusive quantification of clinical efficacy should be performed only on the basis of the clinical end point itself.

Angiographic core laboratory reproducibility analyses: implications for planning clinical trials using coronary angiography and left ventriculography end-points.

PubMed

Steigen, Terje K; Claudio, Cheryl; Abbott, David; Schulzer, Michael; Burton, Jeff; Tymchak, Wayne; Buller, Christopher E; John Mancini, G B

2008-06-01

To assess reproducibility of core laboratory performance and impact on sample size calculations. Little information exists about overall reproducibility of core laboratories in contradistinction to performance of individual technicians. Also, qualitative parameters are being adjudicated increasingly as either primary or secondary end-points. The comparative impact of using diverse indexes on sample sizes has not been previously reported. We compared initial and repeat assessments of five quantitative parameters [e.g., minimum lumen diameter (MLD), ejection fraction (EF), etc.] and six qualitative parameters [e.g., TIMI myocardial perfusion grade (TMPG) or thrombus grade (TTG), etc.], as performed by differing technicians and separated by a year or more. Sample sizes were calculated from these results. TMPG and TTG were also adjudicated by a second core laboratory. MLD and EF were the most reproducible, yielding the smallest sample size calculations, whereas percent diameter stenosis and centerline wall motion require substantially larger trials. Of the qualitative parameters, all except TIMI flow grade gave reproducibility characteristics yielding sample sizes of many 100's of patients. Reproducibility of TMPG and TTG was only moderately good both within and between core laboratories, underscoring an intrinsic difficulty in assessing these. Core laboratories can be shown to provide reproducibility performance that is comparable to performance commonly ascribed to individual technicians. The differences in reproducibility yield huge differences in sample size when comparing quantitative and qualitative parameters. TMPG and TTG are intrinsically difficult to assess and conclusions based on these parameters should arise only from very large trials.

Student Acceptance of the TICCIT System: A Preliminary Study.

ERIC Educational Resources Information Center

Asay, Calvin S.; Schneider, Edward W.

Twenty male and female students from a high school psychology class participated in a formative evaluation of student acceptance and performance with the Primary Instruction Logic of the TICCIT delivery system. A secondary goal was a pilot effort to design a carrel that would optimize certain parameters of the physical/environmental conditions…

Effects of combining vertical and horizontal information into a primary flight display

NASA Technical Reports Server (NTRS)

Abbott, Terence S.; Nataupsky, Mark; Steinmetz, George G.

1987-01-01

A ground-based aircraft simulation study was conducted to determine the effects of combining vertical and horizontal flight information into a single display. Two display configurations were used in this study. The first configuration consisted of a Primary Flight Display (PFD) format and a Horizontal Situation Display (HSD) with the PFD displayed conventionally above the HSD. For the second display configuration, the HSD format was combined with the PFD format. Four subjects participated in this study. Data were collected on performance parameters, pilot-control inputs, auditory evoked response parameters (AEP), oculometer measurements (eye-scan), and heart rate. Subjective pilot opinion was gathered through questionnaire data and scorings for both the Subjective Workload Assessment Technique (SWAT) and the NASA Task Load Index (NASA-TLX). The results of this study showed that, from a performance and subjective standpoint, the combined configuration was better than the separate configuration. Additionally, both the eye-transition and eye-dwell times for the separate HSD were notably higher than expected, with a 46% increase in available visual time when going from double to single display configuration.

Ground-Based Telescope Parametric Cost Model

NASA Technical Reports Server (NTRS)

Stahl, H. Philip; Rowell, Ginger Holmes

2004-01-01

A parametric cost model for ground-based telescopes is developed using multi-variable statistical analysis, The model includes both engineering and performance parameters. While diameter continues to be the dominant cost driver, other significant factors include primary mirror radius of curvature and diffraction limited wavelength. The model includes an explicit factor for primary mirror segmentation and/or duplication (i.e.. multi-telescope phased-array systems). Additionally, single variable models based on aperture diameter are derived. This analysis indicates that recent mirror technology advances have indeed reduced the historical telescope cost curve.

Construction materials as a waste management solution for cellulose sludge

DOE Office of Scientific and Technical Information (OSTI.GOV)

Modolo, R., E-mail: regina.modolo@ua.pt; Ferreira, V.M.; Machado, L.M.

2011-02-15

Sustainable waste management system for effluents treatment sludge has been a pressing issue for pulp and paper sector. Recycling is always recommended in terms of environmental sustainability. Following an approach of waste valorisation, this work aims to demonstrate the technical viability of producing fiber-cement roof sheets incorporating cellulose primary sludge generated on paper and pulp mills. From the results obtained with preliminary studies it was possible to verify the possibility of producing fiber-cement sheets by replacing 25% of the conventional used virgin long fiber by primary effluent treatment cellulose sludge. This amount of incorporation was tested on an industrial scale.more » Environmental parameters related to water and waste, as well as tests for checking the quality of the final product was performed. These control parameters involved total solids in suspension, dissolved salts, chlorides, sulphates, COD, metals content. In the product, parameters like moisture, density and strength were controlled. The results showed that it is possible to replace the virgin long fibers pulp by primary sludge without impacts in final product characteristics and on the environment. This work ensures the elimination of significant waste amounts, which are nowadays sent to landfill, as well as reduces costs associated with the standard raw materials use in the fiber-cement industrial sector.« less

Engineering Inertial and Primary-Frequency Response for Distributed Energy Resources: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dall-Anese, Emiliano; Zhao, Changhong; Guggilam, Swaroop

We propose a framework to engineer synthetic-inertia and droop-control parameters for distributed energy resources (DERs) so that the system frequency in a network composed of DERs and synchronous generators conforms to prescribed transient and steady-state performance specifications. Our approach is grounded in a second-order lumped-parameter model that captures the dynamics of synchronous generators and frequency-responsive DERs endowed with inertial and droop control. A key feature of this reduced-order model is that its parameters can be related to those of the originating higher-order dynamical model. This allows one to systematically design the DER inertial and droop-control coefficients leveraging classical frequency-domain responsemore » characteristics of second-order systems. Time-domain simulations validate the accuracy of the model-reduction method and demonstrate how DER controllers can be designed to meet steady-state-regulation and transient-performance specifications.« less

Engineering Inertial and Primary-Frequency Response for Distributed Energy Resources

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dall-Anese, Emiliano; Zhao, Changhong; Guggilam, Swaroop

We propose a framework to engineer synthetic-inertia and droop-control parameters for distributed energy resources (DERs) so that the system frequency in a network composed of DERs and synchronous generators conforms to prescribed transient and steady-state performance specifications. Our approach is grounded in a second-order lumped-parameter model that captures the dynamics of synchronous generators and frequency-responsive DERs endowed with inertial and droop control. A key feature of this reduced-order model is that its parameters can be related to those of the originating higherorder dynamical model. This allows one to systematically design the DER inertial and droop-control coefficients leveraging classical frequency-domain responsemore » characteristics of second-order systems. Time-domain simulations validate the accuracy of the model-reduction method and demonstrate how DER controllers can be designed to meet steady-state-regulation and transient-performance specifications.« less

Comparative study of the retinal nerve fibre layer thickness performed with optical coherence tomography and GDx scanning laser polarimetry in patients with primary open-angle glaucoma

PubMed Central

Wasyluk, Jaromir T.; Jankowska-Lech, Irmina; Terelak-Borys, Barbara; Grabska-Liberek, Iwona

2012-01-01

Summary Background We compared the parameters of retinal nerve fibre layer in patients with advanced glaucoma with the use of different OCT (Optical Coherence Tomograph) devices in relation to analogical measurements performed with GDx VCC (Nerve Fiber Analyzer with Variable Corneal Compensation) scanning laser polarimetry. Material/Methods Study subjects had advanced primary open-angle glaucoma, previously treated conservatively, diagnosed and confirmed by additional examinations (visual field, ophthalmoscopy of optic nerve, gonioscopy), A total of 10 patients were enrolled (9 women and 1 man), aged 18–70 years of age. Nineteen eyes with advanced glaucomatous neuropathy were examined. 1) Performing a threshold perimetry Octopus, G2 strategy and ophthalmoscopy of optic nerve to confirm the presence of advanced primary open-angle glaucoma; 2) performing a GDx VCC scanning laser polarimetry of retinal nerve fibre layer; 3) measuring the retinal nerve fibre layer thickness with 3 different optical coherence tomographs. Results The parameters of the retinal nerve fibre layer thickness are highly correlated between the GDx and OCT Stratus and 3D OCT-1000 devices in mean retinal nerve fibre layer thickness, retinal nerve fibre layer thickness in the upper sector, and correlation of NFI (GDx) with mean retinal nerve fibre layer thickness in OCT examinations. Absolute values of the retinal nerve fibre layer thickness (measured in μm) differ significantly between GDx and all OCT devices. Conclusions Examination with OCT devices is a sensitive diagnostic method of glaucoma, with good correlation with the results of GDx scanning laser polarimetry of the patients. PMID:22367131

Histopathological Parameters predicting Occult Nodal Metastases in Tongue Carcinoma Cases: An Indian Perspective.

PubMed

Jacob, Tina Elizabeth; Malathi, N; Rajan, Sharada T; Augustine, Dominic; Manish, N; Patil, Shankargouda

2016-01-01

It is a well-established fact that in squamous cell carcinoma cases, the presence of lymph node metastases decreased the 5-year survival rate by 50% and also caused the recurrence of the primary tumor with development of distant metastases. Till date, the predictive factors for occult cervical lymph nodes metastases in cases of tongue squamous cell carcinoma remain inconclusive. Therefore, it is imperative to identify patients who are at the greatest risk for occult cervical metastases. This study was thus performed with the aim to identify various histopathologic parameters of the primary tumor that predict occult nodal metastases. The clinicopathologic features of 56 cases of lateral tongue squamous cell carcinoma with cT1NoMo/cT2NoMo as the stage and without prior radiotherapy or chemotherapy were considered. The surgical excision of primary tumor was followed by elective neck dissection. The glossectomy specimen along with the neck nodes were fixed in formalin and 5 urn thick sections were obtained. The hematoxylin & eosin stained sections were then subjected to microscopic examination. The primary tumor characteristics that were analyzed include tumor grade, invading front, depth of tumor, lymphovascular invasion, perineural invasion and inflammatory response. The nodes were examined for possible metastases using hematoxylin & eosin followed by cytokeratin immunohistochemistry. A total of 12 cases were found with positive occult nodal metastases. On performing univariate analysis, the histopathologic parameters that were found to be statistically significant were lymphovascular invasion (p = 0.004) and perineural invasion (p = 0.003) along with a cut-off depth of infiltration more than 5 mm (p = 0.01). Histopathologic assessment of the primary tumor specimen therefore continues to provide information that is central to guide clinical management, particularly in cases of occult nodal metastases. Clinical significance The study highlights the importance of extensive histopathological screening, which holds the key for establishing occult metastases. Pathological upgrading of tumors is possible following histopathological studies similar to the present one. Presence of occult metastases justify neck dissection in these clinically N0 cases. In an Indian setting, histopathological evaluation assumes a bigger role than other expensive and advanced techniques.

Effects of a Novel Cooling Shirt on Various Physical Performance Parameters in Elite Athletes

DTIC Science & Technology

2015-06-03

operations and sport matches. The primary purpose of this short-term field observation was to determine the effects of a technical cooling shirt and...limit these individuals’ ability to sustain and satisfactorily continue a high level of performance required during intense ground operations and sport ...specially cut-to-size cryotherapy material in place. The subjects were then counter-balanced, with half of the subjects “loaded” with the cooling material

Apollo experience report: Voice communications techniques and performance

NASA Technical Reports Server (NTRS)

Dabbs, J. H.; Schmidt, O. L.

1972-01-01

The primary performance requirement of the spaceborne Apollo voice communications system is percent word intelligibility, which is related to other link/channel parameters. The effect of percent word intelligibility on voice channel design and a description of the verification procedures are included. Development and testing performance problems and the techniques used to solve the problems are also discussed. Voice communications performance requirements should be comprehensive and verified easily; the total system must be considered in component design, and the necessity of voice processing and the associated effect on noise, distortion, and cross talk should be examined carefully.

Intraobserver reproducibility of parameters of standard and 2D speckle tracking echocardiography, dynamics of global longitudinal strain I in patients with acute primary anterior STEMI

NASA Astrophysics Data System (ADS)

Kercheva, M.; Ryabova, T.; Ryabov, V.; Karpov, R.

2015-11-01

The aim of this study was to assess the intraobserver reproducibility of parameters of standard and 2 dimensional speckle tracking echocardiography, dynamics of global longitudinal strain in patients with acute primary anterior STEMI. The study included 24 patients, mean age 58.46±10.2. Echocardiography with 2D speckle tracking imaging was performed on the 1st (T1), 7th (T2), 14th days (T3) after STEMI («Vivid E9»). Analysis of echocardiographic images was performed offline at the different periods by the two independent observers (EchoPac) - experienced and inexperienced. In order to assess the agreement between standard and 2D speckle tracking echocardiography, a correlation analysis (Pearson correlation, Spearman's rank correlation coefficient) and Bland-Altman analysis were undertaken. The 23 patients had urgent reperfusion therapy, 6 patients underwent primary PCI, 16 patients - PCI after successful fibrinolysis (68%). GLS and WMSI had the best intraobsever reproducibility. Dynamics of EDV LV, ESV LV, EF LV was without significant differences. Nevertheless, it was found positive dynamic of GLS: - 12.65±3.53 (T1), -13.61±3.81 (T2), -14.27±4.1 (T3), p<0.05. GLS reduced 11.35% (p=0.0048) from T1 to T3. The best intraobserver reproducibility of parameters of 2 D speckle-tracking and standard echocardiography was revealed in GLS and WMSI. The modern management of STEMI patients limits adverse postinfarction remodeling and preserves of global left ventricular contractility detected by the EF LV. However, GLS had the positive dynamics and improved to the 14th day.

Decision Trees Predicting Tumor Shrinkage for Head and Neck Cancer: Implications for Adaptive Radiotherapy.

PubMed

Surucu, Murat; Shah, Karan K; Mescioglu, Ibrahim; Roeske, John C; Small, William; Choi, Mehee; Emami, Bahman

2016-02-01

To develop decision trees predicting for tumor volume reduction in patients with head and neck (H&N) cancer using pretreatment clinical and pathological parameters. Forty-eight patients treated with definitive concurrent chemoradiotherapy for squamous cell carcinoma of the nasopharynx, oropharynx, oral cavity, or hypopharynx were retrospectively analyzed. These patients were rescanned at a median dose of 37.8 Gy and replanned to account for anatomical changes. The percentages of gross tumor volume (GTV) change from initial to rescan computed tomography (CT; %GTVΔ) were calculated. Two decision trees were generated to correlate %GTVΔ in primary and nodal volumes with 14 characteristics including age, gender, Karnofsky performance status (KPS), site, human papilloma virus (HPV) status, tumor grade, primary tumor growth pattern (endophytic/exophytic), tumor/nodal/group stages, chemotherapy regimen, and primary, nodal, and total GTV volumes in the initial CT scan. The C4.5 Decision Tree induction algorithm was implemented. The median %GTVΔ for primary, nodal, and total GTVs was 26.8%, 43.0%, and 31.2%, respectively. Type of chemotherapy, age, primary tumor growth pattern, site, KPS, and HPV status were the most predictive parameters for primary %GTVΔ decision tree, whereas for nodal %GTVΔ, KPS, site, age, primary tumor growth pattern, initial primary GTV, and total GTV volumes were predictive. Both decision trees had an accuracy of 88%. There can be significant changes in primary and nodal tumor volumes during the course of H&N chemoradiotherapy. Considering the proposed decision trees, radiation oncologists can select patients predicted to have high %GTVΔ, who would theoretically gain the most benefit from adaptive radiotherapy, in order to better use limited clinical resources. © The Author(s) 2015.

Highly light-weighted ZERODUR mirrors

NASA Astrophysics Data System (ADS)

Behar-Lafenetre, Stéphanie; Lasic, Thierry; Viale, Roger; Mathieu, Jean-Claude; Ruch, Eric; Tarreau, Michel; Etcheto, Pierre

2017-11-01

Due to more and more stringent requirements for observation missions, diameter of primary mirrors for space telescopes is increasing. Difficulty is then to have a design stiff enough to be able to withstand launch loads and keep a reasonable mass while providing high opto-mechanical performance. Among the possible solutions, Thales Alenia Space France has investigated optimization of ZERODUR mirrors. Indeed this material, although fragile, is very well mastered and its characteristics well known. Moreover, its thermo-elastic properties (almost null CTE) is unequalled yet, in particular at ambient temperature. Finally, this material can be polished down to very low roughness without any coating. Light-weighting can be achieved by two different means : either optimizing manufacturing parameters or optimizing design (or both). Manufacturing parameters such as walls and optical face thickness have been improved and tested on representative breadboards defined on the basis of SAGEM-REOSC and Thales Alenia Space France expertise and realized by SAGEM-REOSC. In the frame of CNES Research and Technology activities, specific mass has been decreased down to 36 kg/m2. Moreover SNAP study dealt with a 2 m diameter primary mirror. Design has been optimized by Thales Alenia Space France while using classical manufacturing parameters - thus ensuring feasibility and costs. Mass was decreased down to 60 kg/m2 for a gravity effect of 52 nm. It is thus demonstrated that high opto-mechanical performance can be guaranteed with large highly lightweighted ZERODUR mirrors.

Analytically optimal parameters of dynamic vibration absorber with negative stiffness

NASA Astrophysics Data System (ADS)

Shen, Yongjun; Peng, Haibo; Li, Xianghong; Yang, Shaopu

2017-02-01

In this paper the optimal parameters of a dynamic vibration absorber (DVA) with negative stiffness is analytically studied. The analytical solution is obtained by Laplace transform method when the primary system is subjected to harmonic excitation. The research shows there are still two fixed points independent of the absorber damping in the amplitude-frequency curve of the primary system when the system contains negative stiffness. Then the optimum frequency ratio and optimum damping ratio are respectively obtained based on the fixed-point theory. A new strategy is proposed to obtain the optimum negative stiffness ratio and make the system remain stable at the same time. At last the control performance of the presented DVA is compared with those of three existing typical DVAs, which were presented by Den Hartog, Ren and Sims respectively. The comparison results in harmonic and random excitation show that the presented DVA in this paper could not only reduce the peak value of the amplitude-frequency curve of the primary system significantly, but also broaden the efficient frequency range of vibration mitigation.

Implementation of the Global Parameters Determination in Gaia's Astrometric Solution (AGIS)

NASA Astrophysics Data System (ADS)

Raison, F.; Olias, A.; Hobbs, D.; Lindegren, L.

2010-12-01

Gaia is ESA’s space astrometry mission with a foreseen launch date in early 2012. Its main objective is to perform a stellar census of the 1000 Million brightest objects in our galaxy (completeness to V=20 mag) from which an astrometric catalog of micro-arcsec level accuracy will be constructed. A key element in this endeavor is the Astrometric Global Iterative Solution (AGIS). A core part of AGIS is to determine the accurate spacecraft attitude, geometric instrument calibration and astrometric model parameters for a well-behaved subset of all the objects (the ‘primary stars’). In addition, a small number of global parameters will be estimated, one of these being PPN γ. We present here the implementation of the algorithms dedicated to the determination of the global parameters.

Pediatric patients transferred for operative management of appendicitis: are they at a disadvantage?

PubMed

Farach, Sandra M; Danielson, Paul D; Walford, N Elizabeth; Harmel, Richard P; Chandler, Nicole M

2015-09-01

Many pediatric patients are initially diagnosed with appendicitis at referring hospitals and are subsequently transferred to pediatric facilities. We aimed to compare outcomes of patients transferred to a pediatric referral center to those who present primarily for operative management of appendicitis. A retrospective review of 326 patients with operative appendicitis from July 2012 to July 2013 was performed. Demographic data, clinical parameters, and outcomes were analyzed. Transferred (n=222, 68%) and primary patients (n=104, 32%) were similar except for mean age (primary 12.4 vs. transferred 11.2 years, p<0.01). Computed tomography scans were performed in 80% of transferred compared to 40% of primary patients. Primary patients were more likely to present between the hours of 09:00 and 17:59 (52%), while transferred arrived equally across all hours. Both groups were more likely to present with acute appendicitis (primary 56% vs. transfer 61%, p=NS). There was no difference in time of diagnosis to time of appendectomy, length of hospital stay, or 30 day complications (primary 8.6% vs. transfer 5.8%, p=NS). Patients transferred for definitive care of appendicitis are not found to have more advanced disease or have increased complications; however, they are exposed to significantly more ionizing radiation during evaluation for appendicitis. Copyright © 2015 Elsevier Inc. All rights reserved.

The effect of the inductive electric field on ion poloidal rotation in all collisionality regimes for the primary ions in tokamaks

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pan Chengkang; Wang Shaojie; Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, 230031

2007-11-15

The expression for the poloidal rotation velocity of the primary ions that is caused by the parallel inductive electric field in tokamaks and valid in all collisionality regimes is derived via the Hirshman-Sigmar moment approach. Also the expression of the collisional impurity ions poloidal rotation velocity that is caused by the parallel inductive electric field in tokamaks is derived. The poloidal rotation velocities of the primary ions and the impurity ions are sensitive to the primary ion collisionality parameter and the impurity strength parameter. The poloidal rotation velocities of the primary ions and the impurity ions decrease with the primarymore » ion collisionality parameter and decrease with the impurity strength parameter.« less

Reliability of widefield nailfold capillaroscopy and video capillaroscopy in the assessment of patients with Raynaud’s phenomenon.

PubMed

Sekiyama, Juliana Y; Camargo, Cintia Z; Eduardo, Luís; Andrade, C; Kayser, Cristiane

2013-11-01

To analyze the diagnostic performance and reliability of different parameters evaluated by widefield nailfold capillaroscopy (NFC) with those obtained by video capillaroscopy in patients with Raynaud’s phenomenon (RP). Two hundred fifty-two individuals were assessed, including 101 systemic sclerosis (SSc; scleroderma) patients,61 patients with undifferentiated connective tissue disease, 37 patients with primary RP, and 53 controls. Widefield NFC was performed using a stereomicroscope under 10–25 x magnification and direct measurement of all parameters. Video capillaroscopy was performed under 200 x magnification, with the acquirement of 32 images per individual (4 fields per finger in 8 fingers). The following parameters were analyzed in 8 fingers of the hands (excluding thumbs) by both methods: number of capillaries/mm, number of enlarged and giant capillaries, microhemorrhages, and avascular score.Intra- and interobserver reliability was evaluated by performing both examinations in 20 individuals on 2 different days and by 2 long-term experienced observers. There was a significant correlation (P < 0.000) between widefield NFC and video capillaroscopy in the comparison of all parameters. Kappa values and intraclass correlation coefficient analysis showed excellent intra- and interobserver reproducibility for all parameters evaluated by widefield NFC and video capillaroscopy. Bland-Altman analysis showed high agreement of all parameters evaluated in both methods. According to receiver operating characteristic curve analysis, both methods showed a similar performance in discriminating SSc patients from controls. Widefield NFC and video capillaroscopy are reliable and accurate methods and can be used equally for assessing peripheral microangiopathy in RP and SSc patients. Nonetheless, the high reliability obtained may not be similar for less experienced examiners.

Hydro turbine governor’s power control of hydroelectric unit with sloping ceiling tailrace tunnel

NASA Astrophysics Data System (ADS)

Fu, Liang; Wu, Changli; Tang, Weiping

2018-02-01

The primary frequency regulation and load regulation transient process when the hydro turbine governor is under the power mode of hydropower unit with sloping ceiling tailrace are analysed by field test and numerical simulation in this paper. A simulation method based on “three-zone model” to simulate small fluctuation transient process of the sloping ceiling tailrace is proposed. The simulation model of hydraulic turbine governor power mode is established by governor’s PLC program identification and parameter measurement, and the simulation model is verified by the test. The slow-fast-slow “three-stage regulation” method which can improve the dynamic quality of hydro turbine governor power mode is proposed. The power regulation strategy and parameters are optimized by numerical simulation, the performance of primary frequency regulation and load regulation transient process when the hydro turbine governor is under power mode are improved significantly.

Methodology for the systems engineering process. Volume 2: Technical parameters

NASA Technical Reports Server (NTRS)

Nelson, J. H.

1972-01-01

A scheme based on starting the logic networks from the development and mission factors that are of primary concern in an aerospace system is described. This approach required identifying the primary states (design, design verification, premission, mission, postmission), identifying the attributes within each state (performance capability, survival, evaluation, operation, etc), and then developing the generic relationships of variables for each branch. To illustrate this concept, a system was used that involved a launch vehicle and payload for an earth orbit mission. Examination showed that this example was sufficient to illustrate the concept. A more complicated mission would follow the same basic approach, but would have more extensive sets of generic trees and more correlation points between branches. It has been shown that in each system state (production, test, and use), a logic could be developed to order and classify the parameters involved in the translation from general requirements to specific requirements for system elements.

Integration of altitude and airspeed information into a primary flight display via moving-tape formats: Evaluation during random tracking task

NASA Technical Reports Server (NTRS)

Abbott, Terence S.; Nataupsky, Mark; Steinmetz, George G.

1987-01-01

A ground-based aircraft simulation study was conducted to determine the effects on pilot preference and performance of integrating airspeed and altitude information into an advanced electronic primary flight display via moving-tape (linear moving scale) formats. Several key issues relating to the implementation of moving-tape formats were examined in this study: tape centering, tape orientation, and trend information. The factor of centering refers to whether the tape was centered about the actual airspeed or altitude or about some other defined reference value. Tape orientation refers to whether the represented values are arranged in descending or ascending order. Two pilots participated in this study, with each performing 32 runs along seemingly random, previously unknown flight profiles. The data taken, analyzed, and presented consisted of path performance parameters, pilot-control inputs, and electrical brain response measurements.

Comparative Impacts of Scala Vestibuli Versus Scala Tympani Cochlear Implantation on Auditory Performances and Programming Parameters in Partially Ossified Cochleae.

PubMed

Trudel, Mathieu; Côté, Mathieu; Philippon, Daniel; Simonyan, David; Villemure-Poliquin, Noémie; Bussières, Richard

2018-07-01

To compare scala vestibuli versus scala tympani cochlear implantation in terms of postoperative auditory performances and programming parameters in patients with severe scala tympani ossification. Retrospective case-control study. Tertiary referral center. One hundred three pediatric and adult patients who underwent cochlear implant surgery between 2000 and 2016. Three groups were formed: a scala vestibuli group, a scala tympani with ossification group, and a scala tympani without ossification group. Patients were matched based on their age, sex, duration of deafness, and side of implantation (ratio of 1:2:2). Postoperative evaluation of auditory performances and programming parameters following intensive functional rehabilitation program completion. Multimedia adaptive test (MAT), hearing in noise test (HINT SNR +10 dB, HINT SNR +5 dB, and HINT SNR +0 dB), impedances, neural response telemetry thresholds (NRT), neural response imaging thresholds (NRI), comfortable levels (C-levels), and threshold levels (T-levels) were compared between groups. Twenty-one patients underwent scala vestibuli cochlear implantation: 19 adults and two children. Auditory performances were similar between groups, although sentence recognition in a noisy environment was slightly higher in the scala vestibuli group. Impedance values were also higher in the scala vestibuli group, but all other programming parameters were similar between groups. We present the largest series of patients with scala vestibuli cochlear implantation. This approach provides at least comparable auditory performances without having any deleterious effects on programming parameters. This viable and useful insertion route might be the primary surgical alternative when facing partial cochlear ossification.

Characteristics of ring-cusp discharge chambers

NASA Technical Reports Server (NTRS)

Matossian, J. N.; Beattie, J. R.

1991-01-01

Measurements have been obtained for the operating characteristics of a 30 cm diameter ring-cusp ion thruster (RCIT), quantitatively comparing its performance parameters to those of a divergent-field J-series cluster of the same size. The high level of performance established for the RCIT is due to its maintenance of both a higher primary-electron population and Maxwellian-electron temperature, as the beam-ion production cost is reduced to its baseline value. Ion losses to the discharge-chamber walls can be reduced by an applied electrostatic field.

Resident-performed laser peripheral iridotomy in primary angle closure, primary angle closure suspects, and primary angle closure glaucoma.

PubMed

Kam, Jason P; Zepeda, Emily M; Ding, Leona; Wen, Joanne C

2017-01-01

To investigate the power use and complication frequency of resident-performed laser peripheral iridotomy (LPI). A retrospective analysis of 196 eyes from 103 patients who underwent neodymium: yttrium-aluminum-garnet laser iridotomy performed by resident physicians from January 1, 2010 through April 30, 2015 at a university-based county hospital was done. All patients were treated for primary angle closure, primary angle closure suspects, and primary angle closure glaucoma. Data were collected on pre- and post-laser intraocular pressure (IOP), ethnicity, laser parameters and complications. Mean power use and frequency of complications were evaluated. Complications included elevated post-laser IOP at 30-45 minutes (≥8 mmHg), hyphema, aborted procedures, and lasering non-iris structures. The number of repeated LPI procedures, was also recorded. Mean total power used for all residents was 78.2±68.7 mJ per eye. Power use by first-year trainees was significantly higher than second- and third-year trainees (103.5±75.5 mJ versus 73.7±73.8 mJ and 67.2±56.4 mJ, respectively, p =0.011). Complications included hyphema or microhyphema in 17.9% (35/196), IOP spikes in 5.1% (10/196), aborted procedures in 1.1% (3/196) and lasering non-iris structures in 0.5% (1/196). LPI was repeated in 22.4% of cases (44/196) with higher incidence of repeat LPI among non-Caucasian compared to the Caucasian subjects ( p =0.02). Complication rates did not differ with increased training ( p =0.16). Total power used for LPI decreased with increased resident training, while the complication rate did not differ significantly among resident classes. Complication rates were comparable to rates reported in the literature for attending-performed LPIs.

Orbital Motions and the Conservation-Law/Preferred-Frame α_3 Parameter

NASA Astrophysics Data System (ADS)

Iorio, Lorenzo

2014-09-01

We analytically calculate some orbital effects induced by the Lorentz-invariance/ momentum-conservation parameterized post-Newtonian (PPN) parameter α_3 in a gravitationally bound binary system made of a primary orbited by a test particle. We neither restrict ourselves to any particular orbital configuration nor to specific orientations of the primary's spin axis ψ. We use our results to put preliminary upper bounds on α_3 in the weak-field regime by using the latest data from Solar System's planetary dynamics. By linearly combining the supplementary perihelion precessions Δw of the Earth, Mars and Saturn, determined by astronomers with the Ephemerides of Planets and the Moon (EPM) 2011 ephemerides for the general relativistic values of the PPN parameters β = γ = 1, we infer |α_3| ;5 6 × 10^-10. Our result is about three orders of magnitude better than the previous weak-field constraints existing in the literature and of the same order of magnitude of the constraint expected from the future BepiColombo mission to Mercury. It is, by construction, independent of the other preferred-frame PPN parameters α1, α2, both preliminarily constrained down to a ≈ 10^-6 level. Future analyses should be performed by explicitly including α3 and a selection of other PPN parameters in the models fitted by the astronomers to the observations and estimating them in dedicated covariance analyses.

Macular Thickness Variability in Primary Open Angle Glaucoma Patients using Optical Coherence Tomography

PubMed Central

Agarwal, Prakashchand; Sathyan, P; Saini, VK

2014-01-01

ABSTRACT Aim: To compare the difference of retinal macular thickness and macular volume using optical coherence tomography (OCT) in primary open angle glaucoma (POAG) patients with the normal subjects. Materials and methods: This observational case control study included primary open angle glaucoma (POAG) patients (n = 124 eyes) and healthy subjects in the control group (n = 124 eyes). All subjects underwent detailed history, general and systemic exami -nation. Complete ocular examination included best corrected visual acuity (BCVA), slit lamp examination, intraocular pressure (IOP), central corneal thickness, gonioscopy, dilated fundus biomicroscopy. Field analysis was done by white on white Humphrey Field Analyzer (Carl Zeiss). Optical coherence tomography imaging of macular area was performed using Stratus OCT (OCT 3, Version 4, Carl Zeiss Inc, Dublin, California, USA). In both these groups, parameters analyzed were macular thickness, inner macular thicknesses (IMT), outer macular thicknesses (OMT), central macular thick ness (CMT) and total macular volume (TMV). Results: The POAG group had significantly decreased values of TMV, OMT and IMT, compared to control group, while there was no difference in CMT, presumably due to absence of ganglion cells in the central part. Thus, macular thickness and volume parameters may be used for making the diagnosis of glaucoma especially in patients with abnormalities of disc. Conclusion: Macular thickness parameters correlated well with the diagnosis of glaucoma. How to cite this article: Sharma A, Agarwal P, Sathyan P, Saini VK. Macular Thickness Variability in Primary Open Angle Glaucoma Patients using Optical Coherence Tomography. J Current Glau Prac 2014;8(1):10-14. PMID:26997801

Estimating non-isothermal bacterial growth in foods from isothermal experimental data.

PubMed

Corradini, M G; Peleg, M

2005-01-01

To develop a mathematical method to estimate non-isothermal microbial growth curves in foods from experiments performed under isothermal conditions and demonstrate the method's applicability with published growth data. Published isothermal growth curves of Pseudomonas spp. in refrigerated fish at 0-8 degrees C and Escherichia coli 1952 in a nutritional broth at 27.6-36 degrees C were fitted with two different three-parameter 'primary models' and the temperature dependence of their parameters was fitted by ad hoc empirical 'secondary models'. These were used to generate non-isothermal growth curves by solving, numerically, a differential equation derived on the premise that the momentary non-isothermal growth rate is the isothermal rate at the momentary temperature, at a time that corresponds to the momentary growth level of the population. The predicted non-isothermal growth curves were in agreement with the reported experimental ones and, as expected, the quality of the predictions did not depend on the 'primary model' chosen for the calculation. A common type of sigmoid growth curve can be adequately described by three-parameter 'primary models'. At least in the two systems examined, these could be used to predict growth patterns under a variety of continuous and discontinuous non-isothermal temperature profiles. The described mathematical method whenever validated experimentally will enable the simulation of the microbial quality of stored and transported foods under a large variety of existing or contemplated commercial temperature histories.

Eclipsing binary stars with a δ Scuti component

NASA Astrophysics Data System (ADS)

Kahraman Aliçavuş, F.; Soydugan, E.; Smalley, B.; Kubát, J.

2017-09-01

Eclipsing binaries with a δ Sct component are powerful tools to derive the fundamental parameters and probe the internal structure of stars. In this study, spectral analysis of six primary δ Sct components in eclipsing binaries has been performed. Values of Teff, v sin I, and metallicity for the stars have been derived from medium-resolution spectroscopy. Additionally, a revised list of δ Sct stars in eclipsing binaries is presented. In this list, we have only given the δ Sct stars in eclipsing binaries to show the effects of the secondary components and tidal-locking on the pulsations of primary δ Sct components. The stellar pulsation, atmospheric and fundamental parameters (e.g. mass, radius) of 92 δ Sct stars in eclipsing binaries have been gathered. Comparison of the properties of single and eclipsing binary member δ Sct stars has been made. We find that single δ Sct stars pulsate in longer periods and with higher amplitudes than the primary δ Sct components in eclipsing binaries. The v sin I of δ Sct components is found to be significantly lower than that of single δ Sct stars. Relationships between the pulsation periods, amplitudes and stellar parameters in our list have been examined. Significant correlations between the pulsation periods and the orbital periods, Teff, log g, radius, mass ratio, v sin I and the filling factor have been found.

Neutron activation analysis: A primary method of measurement

NASA Astrophysics Data System (ADS)

Greenberg, Robert R.; Bode, Peter; De Nadai Fernandes, Elisabete A.

2011-03-01

Neutron activation analysis (NAA), based on the comparator method, has the potential to fulfill the requirements of a primary ratio method as defined in 1998 by the Comité Consultatif pour la Quantité de Matière — Métrologie en Chimie (CCQM, Consultative Committee on Amount of Substance — Metrology in Chemistry). This thesis is evidenced in this paper in three chapters by: demonstration that the method is fully physically and chemically understood; that a measurement equation can be written down in which the values of all parameters have dimensions in SI units and thus having the potential for metrological traceability to these units; that all contributions to uncertainty of measurement can be quantitatively evaluated, underpinning the metrological traceability; and that the performance of NAA in CCQM key-comparisons of trace elements in complex matrices between 2000 and 2007 is similar to the performance of Isotope Dilution Mass Spectrometry (IDMS), which had been formerly designated by the CCQM as a primary ratio method.

Effect of menopause, anthropometry, nutrition and lifestyle on bone status of women in the northern Mediterranean.

PubMed

Pavicic Zezelj, S; Cvijanovic, O; Micovic, V; Bobinac, D; Crncevic-Orlic, Z; Malatestinic, G

2010-10-01

The purpose of this study was to explore the influence of age, menopause, anthropometry, nutrition and lifestyle on bone status of women of the Northern Mediterranean Region ofCroatia, which is considered the Adriatic Coast of Southeast Europe. Quantitative ultrasound measurement was performed on the women's right heel and the values of the primary parameters (the Broad Ultrasonic Attenuation and the Speed of Sound [BUA and SOS]) were obtained. Dietary data were assessed with specially designed semi-quantitative food frequency questionnaire. Multiple regression analysis was employed to examine the influence of age and anthropometry, as well as hormonal and nutritional factors on BUA and SOS. In all female subjects, both primary parameters were predicted by menopause. Among nutrition and lifestyle factors, carbohydrates were significant predictors for BUA (beta = -0.151, p < 0.05), and smoking is significant predictor for SOS (beta = -0.113, p < 0.05). In premenopausal women, BUA is significantly predicted by body height (beta = 0.71, p < 0.05) and body mass index (beta = 1.44, p < 0.05). In postmenopausal women, both primary parameters are strongly predicted by age and anthropometric parameters. Besides, SOS is significantly predicted by smoking (beta = -0.18, p < 0.01) and alcohol (beta = -0.13, p < 0.05). Besides, SOS is significantly predicted by smoking (beta = -0.18, p < 0.01) and alcohol (beta = -0.13, p < 0.05). Bone quality in women from the Croatian Mediterranean Region mostly depends on their hormonal status. When the effect of menopause is controlled, bone status becomes dependent on age and anthropometry.

Plated wire memory subsystem

NASA Technical Reports Server (NTRS)

Reynolds, L.; Tweed, H.

1972-01-01

The work performed entailed the design, development, construction and testing of a 4000 word by 18 bit random access, NDRO plated wire memory for use in conjunction with a spacecraft imput/output unit and central processing unit. The primary design parameters, in order of importance, were high reliability, low power, volume and weight. A single memory unit, referred to as a qualification model, was delivered.

Root canal anatomy preservation of WaveOne reciprocating files with or without glide path.

PubMed

Berutti, Elio; Paolino, Davide Salvatore; Chiandussi, Giorgio; Alovisi, Mario; Cantatore, Giuseppe; Castellucci, Arnaldo; Pasqualini, Damiano

2012-01-01

This study evaluated the influence of glide path on canal curvature and axis modification after instrumentation with WaveOne Primary reciprocating files. Thirty ISO 15, 0.02 taper Endo Training Blocks were used. In group 1, glide path was created with PathFile 1, 2, and 3 at working length, whereas in group 2, glide path was not performed. In both groups, canals were shaped with WaveOne Primary reciprocating files at working length. Preinstrumentation and postinstrumentation digital images were superimposed and processed with Matlab r2010b software to analyze the curvature radius ratio (CRr) and the relative axis error (rAe), representing canal curvature modification. Data were analyzed with 1-way balanced analyses of variance at 2 levels (P < .05). Glide path was found to be extremely significant for both CRr parameter (F = 9.59; df = 1; P = .004) and rAe parameter (F = 13.55; df = 1; P = .001). Canal modifications seem to be significantly reduced when previous glide path is performed by using the new WaveOne nickel-titanium single-file system. Copyright © 2012 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

Cortical Correlates of Fitts’ Law

PubMed Central

Ifft, Peter J.; Lebedev, Mikhail A.; Nicolelis, Miguel A. L.

2011-01-01

Fitts’ law describes the fundamental trade-off between movement accuracy and speed: it states that the duration of reaching movements is a function of target size (TS) and distance. While Fitts’ law has been extensively studied in ergonomics and has guided the design of human–computer interfaces, there have been few studies on its neuronal correlates. To elucidate sensorimotor cortical activity underlying Fitts’ law, we implanted two monkeys with multielectrode arrays in the primary motor (M1) and primary somatosensory (S1) cortices. The monkeys performed reaches with a joystick-controlled cursor toward targets of different size. The reaction time (RT), movement time, and movement velocity changed with TS, and M1 and S1 activity reflected these changes. Moreover, modifications of cortical activity could not be explained by changes of movement parameters alone, but required TS as an additional parameter. Neuronal representation of TS was especially prominent during the early RT period where it influenced the slope of the firing rate rise preceding movement initiation. During the movement period, cortical activity was correlated with movement velocity. Neural decoders were applied to simultaneously decode TS and motor parameters from cortical modulations. We suggest that sensorimotor cortex activity reflects the characteristics of both the movement and the target. Classifiers that extract these parameters from cortical ensembles could improve neuroprosthetic control. PMID:22275888

Wing optimization for space shuttle orbiter vehicles

NASA Technical Reports Server (NTRS)

Surber, T. E.; Bornemann, W. E.; Miller, W. D.

1972-01-01

The results were presented of a parametric study performed to determine the optimum wing geometry for a proposed space shuttle orbiter. The results of the study establish the minimum weight wing for a series of wing-fuselage combinations subject to constraints on aerodynamic heating, wing trailing edge sweep, and wing over-hang. The study consists of a generalized design evaluation which has the flexibility of arbitrarily varying those wing parameters which influence the vehicle system design and its performance. The study is structured to allow inputs of aerodynamic, weight, aerothermal, structural and material data in a general form so that the influence of these parameters on the design optimization process can be isolated and identified. This procedure displays the sensitivity of the system design of variations in wing geometry. The parameters of interest are varied in a prescribed fashion on a selected fuselage and the effect on the total vehicle weight is determined. The primary variables investigated are: wing loading, aspect ratio, leading edge sweep, thickness ratio, and taper ratio.

Effect of technical parameters on transjugular intrahepatic portosystemic shunts utilizing stent grafts.

PubMed

Andring, Brice; Kalva, Sanjeeva P; Sutphin, Patrick; Srinivasa, Rajiv; Anene, Alvin; Burrell, Marc; Xi, Yin; Pillai, Anil K

2015-07-14

To assess the effect of technical parameters on outcomes of transjugular intrahepatic portosystemic shunt (TIPS) created using a stent graft. The medical records of 68 patients who underwent TIPS placement with a stent graft from 2008 to 2014 were reviewed by two radiologists blinded to the patient outcomes. Digital Subtraction Angiographic images with a measuring catheter in two orthogonal planes was used to determine the TIPS stent-to-inferior vena cava distance (SIVCD), hepatic vein to parenchymal tract angle (HVTA), portal vein to parenchymal tract angle (PVTA), and the accessed portal vein. The length and diameter of the TIPS stent and the use of concurrent variceal embolization were recorded by review of the patient's procedure note. Data on re-intervention within 30 d of TIPS placement, recurrence of symptoms, and survival were collected through the patient's chart. Cox proportional regression analysis was performed to assess the effect of these technical parameters on primary patency of TIPS, time to recurrence of symptoms, and all-cause mortality. There was no significant association between the SIVCD and primary patency (P = 0.23), time to recurrence of symptoms (P = 0.83), or all-cause mortality (P = 0.18). The 3, 6, and 12-mo primary patency rates for a SIVCD ≥ 1.5 cm were 82.4%, 64.7%, and 50.3% compared to 89.3%, 83.8%, and 60.6% for a SIVCD of < 1.5 cm (P = 0.29). The median time to stenosis for a SIVCD of ≥ 1.5 cm was 19.1 mo vs 15.1 mo for a SIVCD of < 1.5 cm (P = 0.48). There was no significant association between the following factors and primary patency: HVTA (P = 0.99), PVTA (P = 0.65), accessed portal vein (P = 0.35), TIPS stent diameter (P = 0.93), TIPS stent length (P = 0.48), concurrent variceal embolization (P = 0.13) and reinterventions within 30 d (P = 0.24). Furthermore, there was no correlation between these technical parameters and time to recurrence of symptoms or all-cause mortality. Recurrence of symptoms was associated with stent graft stenosis (P = 0.03). TIPS stent-to-caval distance and other parameters have no significant effect on primary patency, time to recurrence of symptoms, or all-cause mortality following TIPS with a stent-graft.

Thermal Analysis of the Advanced Technology Large Aperture Space Telescope (ATLAST) 8 Meter Primary Mirror

NASA Technical Reports Server (NTRS)

Hornsby, Linda; Stahl, H. Philip; Hopkins, Randall C.

2010-01-01

The Advanced Technology Large Aperture Space Telescope (ATLAST) preliminary design concept consists of an 8 meter diameter monolithic primary mirror enclosed in an insulated, optical tube with stray light baffles and a sunshade. ATLAST will be placed in orbit about the Sun-Earth L2 and will experience constant exposure to the sun. The insulation on the optical tube and sunshade serve to cold bias the telescope which helps to minimize thermal gradients. The primary mirror will be maintained at 280K with an active thermal control system. The geometric model of the primary mirror, optical tube, sun baffles, and sunshade was developed using Thermal Desktop(R) SINDA/FLUINT(R) was used for the thermal analysis and the radiation environment was analyzed using RADCAD(R). A XX node model was executed in order to characterize the static performance and thermal stability of the mirror during maneuvers. This is important because long exposure observations, such as extra-solar terrestrial planet finding and characterization, require a very stable observatory wave front. Steady state thermal analyses served to predict mirror temperatures for several different sun angles. Transient analyses were performed in order to predict thermal time constant of the primary mirror for a 20 degree slew or 30 degree roll maneuver. This paper describes the thermal model and provides details of the geometry, thermo-optical properties, and the environment which influences the thermal performance. All assumptions that were used in the analysis are also documented. Parametric analyses are summarized for design parameters including primary mirror coatings and sunshade configuration. Estimates of mirror heater power requirements are reported. The thermal model demonstrates results for the primary mirror heated from the back side and edges using a heater system with multiple independently controlled zones.

A Retrospective Comparative Study of Primary Versus Revisional Roux-en-Y Gastric Bypass: Long-Term Results.

PubMed

Dardamanis, Dimitrios; Navez, Julie; Coubeau, Laurent; Navez, Benoit

2018-03-09

To compare the perioperative parameters and excess weight loss between patients operated by laporoscopic Roux-en-Y gastric bypass (LRYGB), as a primary operation or a revisional, for insufficient weight loss after vertical banded gastroplasty (VBG) or adjustable gastric banding (AGB). A retrospective analysis of all patients who underwent a LRYGB was performed for the period 2004-2011. Demographics, preoperative body mass index (BMI), co-morbidities, operation time, conversion rate, perioperative complications, hospitalization period, and % of excess BMI loss (%EBMIL) were investigated and compared between groups. Three hundred forty-two laparoscopic gastric bypass operations were performed, 245 were primary, and 97 revisional. Median follow-up was 30 months (range 0-108 months). Mean BMI (kg/m 2 ) before bypass was 45.2 for primary laparoscopic Roux-en-Y gastric bypass (pLRYGB) and 41.1 for revisional laparoscopic Roux-en-Y gastric bypass (rLRYGB). Median operative time and length of stay were longer for rLRYGB 157.5 versus 235 min (p < 0.001) and 6 versus 6.5 days (p = 0.05). Conversion to laparotomy was performed in eight patients, 0.4% of primary and 7.2% of revisional. Morbidity rate was 6.5% in pLRYGB versus 10% in rLRYGB (NS). There was one death in the primary group. Percentage of EBMIL was significantly lower in the revisional group at 12, 18, and 24 months of follow-up. Revisional and primary gastric bypass have no statistical differences in terms of morbidity. The % of excess BMI loss is lower after revisional gastric bypass during the first 2 years of follow-up. The trend of weight loss or weight regain was similar in both groups.

Behavioural and neuroanatomical correlates of auditory speech analysis in primary progressive aphasias.

PubMed

Hardy, Chris J D; Agustus, Jennifer L; Marshall, Charles R; Clark, Camilla N; Russell, Lucy L; Bond, Rebecca L; Brotherhood, Emilie V; Thomas, David L; Crutch, Sebastian J; Rohrer, Jonathan D; Warren, Jason D

2017-07-27

Non-verbal auditory impairment is increasingly recognised in the primary progressive aphasias (PPAs) but its relationship to speech processing and brain substrates has not been defined. Here we addressed these issues in patients representing the non-fluent variant (nfvPPA) and semantic variant (svPPA) syndromes of PPA. We studied 19 patients with PPA in relation to 19 healthy older individuals. We manipulated three key auditory parameters-temporal regularity, phonemic spectral structure and prosodic predictability (an index of fundamental information content, or entropy)-in sequences of spoken syllables. The ability of participants to process these parameters was assessed using two-alternative, forced-choice tasks and neuroanatomical associations of task performance were assessed using voxel-based morphometry of patients' brain magnetic resonance images. Relative to healthy controls, both the nfvPPA and svPPA groups had impaired processing of phonemic spectral structure and signal predictability while the nfvPPA group additionally had impaired processing of temporal regularity in speech signals. Task performance correlated with standard disease severity and neurolinguistic measures. Across the patient cohort, performance on the temporal regularity task was associated with grey matter in the left supplementary motor area and right caudate, performance on the phoneme processing task was associated with grey matter in the left supramarginal gyrus, and performance on the prosodic predictability task was associated with grey matter in the right putamen. Our findings suggest that PPA syndromes may be underpinned by more generic deficits of auditory signal analysis, with a distributed cortico-subcortical neuraoanatomical substrate extending beyond the canonical language network. This has implications for syndrome classification and biomarker development.

Improved photosynthetic efficacy of maize (Zea mays) plants with arbuscular mycorrhizal fungi (AMF) under high temperature stress.

PubMed

Mathur, Sonal; Sharma, Mahaveer P; Jajoo, Anjana

2018-03-01

In this study, pot experiments were performed to investigate the effects of high temperature stress (44 °C) in maize plants colonized with and without arbuscular mycorrhizal fungi (AMF). Various parameters characterizing photosynthetic activity were measured in order to estimate the photosynthetic efficiency in maize plants. It was observed that density of active reaction centers of PSII, quantum efficiency of photosystem II (PSII), linear electron transport, excitation energy trapping, performance index, net photosynthesis rate increased in AMF (+) plants at 44 °C ± 0.2 °C. Efficiency of primary photochemical reaction (represented as F v /F o ) increased in AMF (+) plants as compared to AMF (-) plants. AMF seems to have protected water splitting complex followed by enhanced primary photochemistry of PSII under high temperature. Basic morphological parameters like leaf width, plant height and cob number increased in AMF (+) plants as compared to AMF (-) plants. AMF (+) plants grew faster than AMF (-) plants due to larger root systems. Chl content increased in AMF (+) plants as compared to AMF (-) maize plants. AMF hyphae likely increased Mg uptake which in turn increased the total chlorophyll content in AMF (+) maize plants. This subsequently led to a higher production in photosynthate and biomass. Thus AMF (+) plants have shown better photosynthesis performance as compared to AMF (-) maize plants under high temperature stress. Copyright © 2018 Elsevier B.V. All rights reserved.

A primary method for the complex calibration of a hydrophone from 1 Hz to 2 kHz

NASA Astrophysics Data System (ADS)

Slater, W. H.; E Crocker, S.; Baker, S. R.

2018-02-01

A primary calibration method is demonstrated to obtain the magnitude and phase of the complex sensitivity for a hydrophone at frequencies between 1 Hz and 2 kHz. The measurement is performed in a coupler reciprocity chamber (‘coupler’) a closed test chamber where time harmonic oscillations in pressure can be achieved and the reciprocity conditions required for a primary calibration can be realized. Relevant theory is reviewed and the reciprocity parameter updated for the complex measurement. Systematic errors and corrections for magnitude are reviewed and more added for phase. The combined expanded uncertainties of the magnitude and phase of the complex sensitivity at 1 Hz were 0.1 dB re 1 V μ Pa-1 and  ± 1\\circ , respectively. Complex sensitivity, sensitivity magnitude, and phase measurements are presented on an example primary reference hydrophone.

A new bio-optical model to estimate phytoplankton primary production: An application in the eastern Mediterranean Sea

NASA Astrophysics Data System (ADS)

Stefanì, Chiara; Bonamano, Simone; Melchiorri, Cristiano; Piermattei, Viviana; Fani, Fabiola; Lazzara, Luigi; Marcelli, Marco

2015-04-01

The estimation of phytoplankton primary production provides basic input for the quantification of carbon flux in the ocean because of the strong relationship between available photosynthetic energy at the ocean surface and energy storage by algal photosynthesis. We used a new version of PhytoVFP (Variable Fluorescence Phytoplankton Production) bio-optical model to calculate phytoplankton primary production (PP) in the euphotic zone. PhytoVFP is classified as a Wavelength- and Depth-resolved (WRDR) model and is based on the implementation of photosynthetic efficiency (Fv / Fmax), measured in-situ by the PrimProd probe. An innovation of the model is the reproduction of the daily photoacclimation process by varying photosynthetic parameters (Ek, alfa and Pbmax ) along the water column as a function of stratification. The PhytoVFP model is structured into three main modules: (1) "PAR estimation ";- (2) "Photo-acclimation of marine phytoplankton"; - (3) "Phytoplankton primary production estimation". The performance of the PhytoVFP model was evaluated using PAR and 14C primary production measures collected during the SAMCA3 and SAMCA4 oceanographic cruises. The comparison between the measured and calculated radiation showed a good correlation, both in the surface and along the water column (R2 = 0.8992 in the presence, and R2 = 0.8747 in the absence, of clouds) Sensitivity tests, carried out on phie (photosynthetic quantum yield) and beta (photoinhibition parameter), allowed us to identify the best model parametrization which minimized the MAE (Mean Absolute Error). The values assigned to these parameters allowed to have a good correlation between the measured and estimated primary production values (R² = 0.808923). The results of PhytoVFP model have been also compared with its older version and the Morel (1991) model showing that the MAE of the new version is lower than the other models. The PhytoVFP model was applied on Primprod data collected during MedGOOS12 cruise in order to analyse the vertical distribution of phytoplankton primary production in the eastern Mediterranean sea.

What Preoperative Radiographic Parameters Are Associated With Increased Medial Release in Total Knee Arthroplasty?

PubMed

Martin, J Ryan; Jennings, Jason M; Levy, Daniel L; Watters, Tyler Steven; Miner, Todd M; Dennis, Douglas A

2017-03-01

Preoperative varus deformity of the knee is a common malalignment in patients undergoing primary total knee arthroplasty (TKA). We are unaware of any studies that have correlated how various preoperative radiographic parameters can predict the amount of medial releases performed to achieve optimal coronal alignment and ligamentous balance. A retrospective review was performed on 67 patients who required at least a medial tibial reduction osteotomy (MTRO) during primary TKA to achieve coronal balance. This patient population was matched 1:1 to another cohort of TKA patients by age, gender, and body mass index who did not require an MTRO. A radiographic evaluation was used to compare the 2 cohorts. Preoperatively, the MTRO cohort was noted to have significantly increased varus tibiofemoral (86.12° vs 93.43°), tibial articular surface (85.79° vs 87.54°), and medial tibial articular surface angles (75.22° vs 85.34°) compared to the control cohort. The MTRO cohort had 3.13 mm of medial tibial offset and 9.06 mm of lateral joint space opening and the control cohort had 0.09 mm and 4.07 mm, respectively. The medial tibial articular surface angle and lateral joint space widening were statistically associated with the MTRO cohort. The final tibiofemoral angle in the MTRO cohort was 92.43° and was 93.40° in the control cohort. The MTRO cohort was noted to have several preoperative radiographic parameters that were significantly different than the control cohort. However, the medial tibial articular surface angle and lateral joint space widening were the only radiographic parameters that were statistically associated with requiring an MTRO. Copyright © 2016 Elsevier Inc. All rights reserved.

Differentiating between Glioblastoma and Primary CNS Lymphoma Using Combined Whole-tumor Histogram Analysis of the Normalized Cerebral Blood Volume and the Apparent Diffusion Coefficient.

PubMed

Bao, Shixing; Watanabe, Yoshiyuki; Takahashi, Hiroto; Tanaka, Hisashi; Arisawa, Atsuko; Matsuo, Chisato; Wu, Rongli; Fujimoto, Yasunori; Tomiyama, Noriyuki

2018-05-31

This study aimed to determine whether whole-tumor histogram analysis of normalized cerebral blood volume (nCBV) and apparent diffusion coefficient (ADC) for contrast-enhancing lesions can be used to differentiate between glioblastoma (GBM) and primary central nervous system lymphoma (PCNSL). From 20 patients, 9 with PCNSL and 11 with GBM without any hemorrhagic lesions, underwent MRI, including diffusion-weighted imaging and dynamic susceptibility contrast perfusion-weighted imaging before surgery. Histogram analysis of nCBV and ADC from whole-tumor voxels in contrast-enhancing lesions was performed. An unpaired t-test was used to compare the mean values for each type of tumor. A multivariate logistic regression model (LRM) was performed to classify GBM and PCNSL using the best parameters of ADC and nCBV. All nCBV histogram parameters of GBMs were larger than those of PCNSLs, but only average nCBV was statistically significant after Bonferroni correction. Meanwhile, ADC histogram parameters were also larger in GBM compared to those in PCNSL, but these differences were not statistically significant. According to receiver operating characteristic curve analysis, the nCBV average and ADC 25th percentile demonstrated the largest area under the curve with values of 0.869 and 0.838, respectively. The LRM combining these two parameters differentiated between GBM and PCNSL with a higher area under the curve value (Logit (P) = -21.12 + 10.00 × ADC 25th percentile (10 -3 mm 2 /s) + 5.420 × nCBV mean, P < 0.001). Our results suggest that whole-tumor histogram analysis of nCBV and ADC combined can be a valuable objective diagnostic method for differentiating between GBM and PCNSL.

Analytical and computational studies on the vacuum performance of a chevron ejector

NASA Astrophysics Data System (ADS)

Kong, F. S.; Jin, Y. Z.; Kim, H. D.

2016-11-01

The effects of chevrons on the performance of a supersonic vacuum ejector-diffuser system are investigated numerically and evaluated theoretically in this work. A three-dimensional geometrical domain is numerically solved using a fully implicit finite volume scheme based on the unsteady Reynolds stress model. A one-dimensional mathematical model provides a useful tool to reveal the steady flow physics inside the vacuum ejector-diffuser system. The effects of the chevron nozzle on the generation of recirculation regions and Reynolds stress behaviors are studied and compared with those of a conventional convergent nozzle. The present performance parameters obtained from the simulated results and the mathematical results are validated with existing experimental data and show good agreement. Primary results show that the duration of the transient period and the secondary chamber pressure at a dynamic equilibrium state depend strongly on the primary jet conditions, such as inlet pressure and primary nozzle shape. Complicated oscillatory flow, generated by the unsteady movement of recirculation, finally settles into a dynamic equilibrium state. As a vortex generator, the chevron demonstrated its strong entrainment capacity to accelerate the starting transient flows to a certain extent and reduce the dynamic equilibrium pressure of the secondary chamber significantly.

Calibrating the metallicity of M dwarfs in wide physical binaries with F-, G-, and K- primaries - I: High-resolution spectroscopy with HERMES: stellar parameters, abundances, and kinematics

NASA Astrophysics Data System (ADS)

Montes, D.; González-Peinado, R.; Tabernero, H. M.; Caballero, J. A.; Marfil, E.; Alonso-Floriano, F. J.; Cortés-Contreras, M.; González Hernández, J. I.; Klutsch, A.; Moreno-Jódar, C.

2018-05-01

We investigated almost 500 stars distributed among 193 binary or multiple systems made of late-F, G-, or early-K primaries and late-K or M dwarf companion candidates. For all of them, we compiled or measured coordinates, J-band magnitudes, spectral types, distances, and proper motions. With these data, we established a sample of 192 physically bound systems. In parallel, we carried out observations with HERMES/Mercator and obtained high-resolution spectra for the 192 primaries and five secondaries. We used these spectra and the automatic STEPAR code for deriving precise stellar atmospheric parameters: Teff, log g, ξ, and chemical abundances for 13 atomic species, including [Fe/H]. After computing Galactocentric space velocities for all the primary stars, we performed a kinematic analysis and classified them in different Galactic populations and stellar kinematic groups of very different ages, which match our own metallicity determinations and isochronal age estimations. In particular, we identified three systems in the halo and 33 systems in the young Local Association, Ursa Major and Castor moving groups, and IC 2391 and Hyades Superclusters. We finally studied the exoplanet-metallicity relation in our 193 primaries and made a list 13 M-dwarf companions with very high metallicity that can be the targets of new dedicated exoplanet surveys. All in all, our dataset will be of great help for future works on the accurate determination of metallicity of M dwarfs.

Effects of platelet rich plasma on fascial healing in rats with fecal peritonitis

PubMed

Girgin, Mustafa; Binnetoglu, Kenan; Duman, Kazim; Kanat, Burhan Hakan; Cetinkaya, Ziya; Ayten, Refik; Ilhan, Yavuz Selim; Ilhan, Necip; Seker, Ibrahim; Timurkaan, Necati

2016-05-01

To evaluate the effects of platelet rich plasma (PRP) on the healing of fascia wherein peritonitis has been created. Twenty eight Wistar Albino rats were divided into four groups. Only a primary fascial repair following laparotomy was performed on Group 1, a primary fascial repair performed and PRP treatment applied following laparotomy on Group 2, and a fecal peritonitis created following laparotomy and a primary fascial repair carried out on Group 3. A fecal peritonitis was created following laparotomy and primary fascial repair and PRP treatment on the fascia was carried out on Group 4. TNF-α was found to be significantly lower in the control group (Group 1). It was detected at the highest level in the group in which fecal peritonitis was created and PRP applied (Group 4). TGF-β was determined as being significantly higher only in Group 4. Histopathologically, the differences between the groups in terms of cell infiltration and collagen deposition were not found to be significant. When platelet rich plasma was given histologically and biochemicaly as wound healing parameters cellular infiltration, collagen accumulation, and tissue hydroxyiproline levels were not increased but neovascularization, fibroblast activation and TNF Alfa levels were increased and PRP accelerated wound healing.

On-sky performance of the Zernike phase contrast sensor for the phasing of segmented telescopes.

PubMed

Surdej, Isabelle; Yaitskova, Natalia; Gonte, Frederic

2010-07-20

The Zernike phase contrast method is a novel technique to phase the primary mirrors of segmented telescopes. It has been tested on-sky on a unit telescope of the Very Large Telescope with a segmented mirror conjugated to the primary mirror to emulate a segmented telescope. The theoretical background of this sensor and the algorithm used to retrieve the piston, tip, and tilt information are described. The performance of the sensor as a function of parameters such as star magnitude, seeing, and integration time is discussed. The phasing accuracy has always been below 15 nm root mean square wavefront error under normal conditions of operation and the limiting star magnitude achieved on-sky with this sensor is 15.7 in the red, which would be sufficient to phase segmented telescopes in closed-loop during observations.

The Estimation of the IRT Reliability Coefficient and Its Lower and Upper Bounds, with Comparisons to CTT Reliability Statistics

ERIC Educational Resources Information Center

Kim, Seonghoon; Feldt, Leonard S.

2010-01-01

The primary purpose of this study is to investigate the mathematical characteristics of the test reliability coefficient rho[subscript XX'] as a function of item response theory (IRT) parameters and present the lower and upper bounds of the coefficient. Another purpose is to examine relative performances of the IRT reliability statistics and two…

Laboratory Experiments on Bentonite Samples: FY16 Progress

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ruth M. Tinnacher; Tournassat, Christophe; James A. Davis

2016-08-22

The primary goal of this study is to improve the understanding of U(VI) sorption and diffusion behavior in sodium-montmorillonite in order to support the development of realistic conceptual models describing these processes in performance assessment models while (1) accounting for potential changes in system conditions over time and space, (2) avoiding overly conservative transport predictions, and (3) using a minimum number of fitting parameters.

Area 18 of the cat: the first step in processing visual movement information.

PubMed

Orban, G A

1977-01-01

In cats, responses of area 18 neurons to different moving patterns were measured. The influence of three movement parameters--direction, angular velocity, and amplitude of movement--were tested. The results indicate that in area 18 no ideal movement detector exists, but that simple and complex cells each perform complementary operations of primary visual areas, i.e. analysis and detection of movement.

Correlation of human papilloma virus status with quantitative perfusion/diffusion/metabolic imaging parameters in the oral cavity and oropharyngeal squamous cell carcinoma: comparison of primary tumour sites and metastatic lymph nodes.

PubMed

Han, M; Lee, S J; Lee, D; Kim, S Y; Choi, J W

2018-05-17

To investigate the differences in perfusion/diffusion/metabolic imaging parameters according to human papilloma virus (HPV) status in the oral cavity and oropharyngeal squamous cell carcinoma (OC-OPSCC), separately in primary tumour sites and metastatic lymph nodes. This retrospective study comprised 41 patients with primary OC-OPSCCs and 29 patients with metastatic lymph nodes. The perfusion/diffusion/metabolic imaging parameters were measured at the primary tumour and the largest ipsilateral metastatic lymph node. The quantitative parameters were compared between the HPV-positive and -negative groups. The HPV-positivity was 39% (16 patients) for the primary tumours and 51.7% (15 patients) for the metastatic lymph nodes. Patients with HPV-positive tumours had a lower T stage (p=0.034). The metastatic lymph nodes for the HPV-positive patients were bulkier (p=0.016) and more frequently had cystic morphology (p=0.005). The perfusion parameters were not different, regardless of HPV status. The diffusion parameter (ADC min , p=0.011) of the metastatic lymph nodes in the HPV-positive groups was lower and metabolic parameter (metabolic tumour volume p=0.035 and total lesion glycolysis p=0.037) were higher than those in HPV-negative groups. The diffusion and metabolic parameters of metastatic lymph nodes from OC-OPSCC were different according to HPV status. The perfusion parameters did not clearly represent HPV status. Copyright © 2018 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

Optimization of the water chemistry of the primary coolant at nuclear power plants with VVER

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barmin, L. F.; Kruglova, T. K.; Sinitsyn, V. P.

2005-01-15

Results of the use of automatic hydrogen-content meter for controlling the parameter of 'hydrogen' in the primary coolant circuit of the Kola nuclear power plant are presented. It is shown that the correlation between the 'hydrogen' parameter in the coolant and the 'hydrazine' parameter in the makeup water can be used for controlling the water chemistry of the primary coolant system, which should make it possible to optimize the water chemistry at different power levels.

High accuracy fuel flowmeter

NASA Technical Reports Server (NTRS)

1986-01-01

All three flowmeter concepts (vortex, dual turbine, and angular momentum) were subjected to experimental and analytical investigation to determine the potential portotype performance. The three concepts were subjected to a comprehensive rating. Eight parameters of performance were evaluated on a zero-to-ten scale, weighted, and summed. The relative ratings of the vortex, dual turbine, and angular momentum flowmeters are 0.71, 1.00, and 0.95, respectively. The dual turbine flowmeter concept was selected as the primary candidate and the angular momentum flowmeter as the secondary candidate for prototype development and evaluation.

Design and Construction for Community Health Service Precision Fund Appropriation System Based on Performance Management.

PubMed

Gao, Xing; He, Yao; Hu, Hongpu

2017-01-01

Allowing for the differences in economy development, informatization degree and characteristic of population served and so on among different community health service organizations, community health service precision fund appropriation system based on performance management is designed, which can provide support for the government to appropriate financial funds scientifically and rationally for primary care. The system has the characteristic of flexibility and practicability, in which there are five subsystems including data acquisition, parameter setting, fund appropriation, statistical analysis system and user management.

Effects of matrix shrinkage and swelling on the economics of enhanced-coalbed-methane production and CO{sub 2} sequestration in coal

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gorucu, F.B.; Jikich, S.A.; Bromhal, G.S.

2007-08-15

In this work, the Palmer-Mansoori model for coal shrinkage and permeability increases during primary methane production was rewritten to also account for coal swelling caused by CO{sub 2} sorption. The generalized model was added to a compositional, dual porosity coalbed-methane reservoir simulator for primary (CBM) and ECBM production. A standard five-spot of vertical wells and representative coal properties for Appalachian coals was used. Simulations and sensitivity analyses were performed with the modified simulator for nine different parameters, including coal seam and operational parameters and economic criteria. The coal properties and operating parameters that were varied included Young's modulus, Poisson's ratio,more » cleat porosity, and injection pressure. The economic variables included CH{sub 4}, price, Col Cost, CO{sub 2} credit, water disposal cost, and interest rate. Net-present value (NPV) analyses of the simulation results included profits resulting from CH{sub 4}, production and potential incentives for sequestered CO{sub 2}, This work shows that for some coal seams, the combination of compressibility, cleat porosity, and shrinkage/swelling of the coal may have a significant impact on project economics.« less

Macrostructural and Microstructural Brain Lesions Relate to Gait Pathology in Children With Cerebral Palsy.

PubMed

Meyns, Pieter; Van Gestel, Leen; Leunissen, Inge; De Cock, Paul; Sunaert, Stefan; Feys, Hilde; Duysens, Jacques; Desloovere, Kaat; Ortibus, Els

2016-10-01

Background Even though lower-limb motor disorders are core features of spastic cerebral palsy (sCP), the relationship with brain lesions remains unclear. Unraveling the relation between gait pathology, lower-limb function, and brain lesions in sCP is complex for several reasons; wide heterogeneity in brain lesions, ongoing brain maturation, and gait depends on a number of primary motor functions/deficits (eg, muscle strength, spasticity). Objective To use a comprehensive approach combining conventional MRI and diffusion tensor imaging (DTI) in children with sCP above 3 years old to relate quantitative parameters of brain lesions in multiple brain areas to gait performance. Methods A total of 50 children with sCP (25 bilateral, 25 unilateral involvement) were enrolled. The investigated neuroradiological parameters included the following: (1) volumetric measures of the corpus callosum (CC) and lateral ventricles (LVs), and (2) DTI parameters of the corticospinal tract (CST). Gait pathology and primary motor deficits, including muscle strength and spasticity, were evaluated by 3D gait analysis and clinical examination. Results In bilateral sCP (n = 25), volume of the LV and the subparts of the CC connecting frontal, (pre)motor, and sensory areas were most related to lower-limb functioning and gait pathology. DTI measures of the CST revealed additional relations with the primary motor deficits (n = 13). In contrast, in unilateral sCP, volumetric (n = 25) and diffusion measures (n = 14) were only correlated to lower-limb strength. Conclusions These results indicate that the combined influence of multiple brain lesions and their impact on the primary motor deficits might explain a large part of the gait pathology in sCP. © The Author(s) 2016.

Changes in the retrobulbar arterial circulation after decrease of the elevated intraocular pressure in men and women with primary open angle glaucoma.

PubMed

Marjanović, Ivan; Martinez, Antonio; Marjanović, Marija; Kontić, Djordje; Hentova-Senćanić, Paraskeva; Marković, Vujica; Bozić, Marija

2013-01-01

An altered perfusion of the optic nerve head has been proposed as a pathogenic factor of glaucoma. The aim of this study was to evaluate the changes of the hemodynamic parameters in the retrobulbar arterial circulation after decrease of the elevated intraocular pressure (IOP) in women and men with primary open angle glaucoma. The study included 60 patients (33 males and 27 females) older than 50 years, with diagnosed and treated primary open angle glaucoma (77 eyes of 39 patients had increased IOP, > 25 mm Hg).They were examined at the Clinic of Eye Diseases (complete ophthalmologic exam) and Clinic of Neurology, Clinical Center of Serbia, Belgrade, from December 2009 to December 2010. Imaging of hemodynamic parameters of three retrobulbar arterial vessels: ophthalmic, central retinal and posterior ciliary arteries with color Doppler was performed. Among women, hemodynamic arterial parameter of the peak-systolic velocity was increased in the central retinal artery and decreased in the ophthalmic artery and posterior ciliary arteries; end-diastolic velocity was increased in all three retrobulbar vascular levels; Pourcelot resistivity index was increased, but pulsatility index was decreased in all three vessels. Among men, peak-systolic velocity, end-diastolic velocity and pulsatility index were decreased in all three vessels; resistivity index was increased in the ophthalmic artery, but decreased in the central retinal artery and posterior ciliary arteries. There was a significant change of the ophthalmic artery pulsatility index in women, and the end-diastolic velocity of the ophthalmic artery in men. There was a difference of the retrobulbar arterial circulation between women and men with primary open angle glaucoma after decrease of the elevated intraocular pressure.The role of vascular factors in the supply of the optic disc neuroretinal rim is important.

Left ventricular performance in various heart diseases with or without heart failure:--an appraisal by quantitative one-plane cineangiocardiography.

PubMed

Lien, W P; Lee, Y S; Chang, F Z; Chen, J J; Shieh, W B

1978-01-01

Quantitative one-plane cineangiocardiography in right anterior oblique position for evaluation of LV performance was carried out in 62 patients with various heart diseases and in 13 subjects with normal LV. Parameters for evaluating both pump and muscle performances were derived from volume and pressure measurements. Of 31 patients with either systolic hypertension or LV myocardial diseases (coronary artery disease or idiopathic cardiomyopathy), 14 had clinical evidence of LV failure before the study. It was found that mean VCF and EF were most sensitive indicators of impaired LV performance among the various parameters. There was a close correlation between mean VCF and EF, yet discordant changes of both parameters were noted in some patients. Furthermore, wall motion abnormalities were not infrequently observed in patients with coronary artery disease or primary cardiomyopathy. Therefore, assessment of at least three ejection properties (EF, mean VCF and wall motion abnormalities) are considered to be essential for full understanding of derangement of LV function in heart disease. This is especially true of patients with coronary artery disease. LV behavior in relation to different pathological stresses or lesions, such as chronic pressure or volume load, myocardial disease and mitral stenosis, was also studied and possible cause of impaired LV myocardial function in mitral stenosis was discussed.

Analysis of DC and analog/RF performance on Cyl-GAA-TFET using distinct device geometry

NASA Astrophysics Data System (ADS)

Vishvakarma, S. K.; Beohar, Ankur; Vijayvargiya, Vikas; Trivedi, Priyal

2017-07-01

In this paper, analysis of DC and analog/RF performance on cylindrical gate-all-around tunnel field-effect transistor (TFET) has been made using distinct device geometry. Firstly, performance parameters of GAA-TFET are analyzed in terms of drain current, gate capacitances, transconductance, source-drain conductance at different radii and channel length. Furthermore, we also produce the geometrical analysis towards the optimized investigation of radio frequency parameters like cut-off frequency, maximum oscillation frequency and gain bandwidth product using a 3D technology computer-aided design ATLAS. Due to band-to-band tunneling based current mechanism unlike MOSFET, gate-bias dependence values as primary parameters of TFET differ. We also analyze that the maximum current occurs when radii of Si is around 8 nm due to high gate controllability over channel with reduced fringing effects and also there is no change in the current of TFET on varying its length from 100 to 40 nm. However current starts to increase when channel length is further reduced for 40 to 30 nm. Both of these trades-offs affect the RF performance of the device. Project supported by the Council of Scientific and Industrial Research (CSIR) Funded Research Project, Grant No. 22/0651/14/EMR-II, Government of India.

Extending solid state laser performance

NASA Astrophysics Data System (ADS)

Miesak, Ed

2017-02-01

Coherent Diode-Pumped Solid-State Orlando (CDO), formerly known as Lee Laser, headquartered in Orlando Florida produces CW and pulsed solid state lasers. Primary wavelengths include 1064 nm, 532 nm, and 355 nm. Other wavelengths produced include 1320 nm, 15xx nm, and 16xx nm. Pulse widths are in the range of singles to hundreds of nanoseconds. Average powers are in the range of a few watts to 1000 watts. Pulse repetition rates are typically in the range of 100 Hz to 100 KHz. Laser performance parameters are often modified according to customer requests. Laser parameters that can be adjusted include average power, pulse repetition rate, pulse length, beam quality, and wavelength. Laser parameters are typically cross-coupled such that adjusting one may change some or all of the others. Customers often request one or more parameters be changed without changing any of the remaining parameters. CDO has learned how to accomplish this successfully with rapid turn-around times and minimal cost impact. The experience gained by accommodating customer requests has produced a textbook of cause and effect combinations of laser components to accomplish almost any parameter change request. Understanding the relationships between component combinations provides valuable insight into lasing effects allowing designers to extend laser performance beyond what is currently available. This has led to several break through products, i.e. >150W average power 355 nm, >60W average power 6 ps 1064 nm, pulse lengths longer than 400 ns at 532 nm with average power >100W, >400W 532 nm with pulse lengths in the 100 ns range.

A simple mathematical model of society collapse applied to Easter Island

NASA Astrophysics Data System (ADS)

Bologna, M.; Flores, J. C.

2008-02-01

In this paper we consider a mathematical model for the evolution and collapse of the Easter Island society. Based on historical reports, the available primary resources consisted almost exclusively in the trees, then we describe the inhabitants and the resources as an isolated dynamical system. A mathematical, and numerical, analysis about the Easter Island community collapse is performed. In particular, we analyze the critical values of the fundamental parameters and a demographic curve is presented. The technological parameter, quantifying the exploitation of the resources, is calculated and applied to the case of another extinguished civilization (Copán Maya) confirming the consistency of the adopted model.

Design and Performance of the Terrestrial Planet Finder Coronagraph

NASA Technical Reports Server (NTRS)

White, Mary L.; Shaklan, Stuart; Lisman, P. Doulas; Ho, Timothy; Mouroulis, Pantazis; Basinger, Scott; Ledeboer, Bill; Kwack, Eug; Kissil, Andy; Mosier, Gary;

Improving stability and curving passing performance for railway vehicles with a variable stiffness MRF rubber joint

NASA Astrophysics Data System (ADS)

Harris, B. J.; Sun, S. S.; Li, W. H.

2017-03-01

With the growing need for effective intercity transport, the need for more advanced rail vehicle technology has never been greater. The conflicting primary longitudinal suspension requirements of high speed stability and curving performance limit the development of rail vehicle technology. This paper presents a novel magnetorheological fluid based joint with variable stiffness characteristics for the purpose of overcoming this parameter conflict. Firstly, the joint design and working principle is developed. Following this, a prototype is tested by MTS to characterize its variable stiffness properties under a range of conditions. Lastly, the performance of the proposed MRF rubber joint with regard to improving train stability and curving performance is numerically evaluated.

Performance and cost benefits associated with nonimaging secondary concentrators used in point-focus dish solar thermal applications

NASA Astrophysics Data System (ADS)

Ogallagher, J.; Winston, R.

1987-09-01

Using nonimaging secondary concentrators in point-focus applications may permit the development of more cost-effective concentrator systems by either improving performance or reducing costs. Secondaries may also increase design flexibility. The major objective of this study was to develop as complete an understanding as possible of the quantitative performance and cost effects associated with deploying nonimaging secondary concentrators at the focal zone of point-focus solar thermal concentrators. A performance model was developed that uses a Monte Carlo ray-trace procedure to determine the focal plane distribution of a paraboloidal primary as a function of optical parameters. It then calculates the corresponding optimized concentration and thermal efficiency as a function of temperature with and without the secondary. To examine the potential cost benefits associated with secondaries, a preliminary model for the rational optimization of performance versus cost trade-offs was developed. This model suggests a possible 10 to 20 percent reduction in the cost of delivered energy when secondaries are used. This is a lower limit, and the benefits may even be greater if using a secondary permits the development of inexpensive primary technologies for which the performance would not otherwise be viable.

CCD charge collection efficiency and the photon transfer technique

NASA Technical Reports Server (NTRS)

Janesick, J.; Klaasen, K.; Elliott, T.

1985-01-01

The charge-coupled device (CCD) has shown unprecendented performance as a photon detector in the areas of spectral response, charge transfer, and readout noise. Recent experience indicates, however, that the full potential for the CCD's charge collection efficiency (CCE) lies well beyond that which is realized in currently available devices. A definition of CCE performance is presented and a standard test tool (the photon transfer technique) for measuring and optimizing this important CCD parameter is introduced. CCE characteristics for different types of CCDs are compared; the primary limitations in achieving high CCE performance are discussed, and the prospects for future improvement are outlined.

Language Parameters of 4- to 7-Year-Old Persian-Speaking Children with Cleft Lip and Palate.

PubMed

Ghayoumi Anaraki, Zahra; Faham, Maryam; Derakhshandeh, Fatemeh; Hashemi Hosseinabad, Hedieh; Haresabadi, Fatemeh

2016-01-01

There are several risk factors including hearing difficulties, lack of language stimulation, and parents' low level of expectation leading to language disorders in children with cleft palate. Therefore, formal language assessments of children with cleft palate are of great importance in order to prevent further disabilities. The purpose of the present study is to evaluate language parameters in 4- to 7-year old Persian-speaking children with cleft palate. 16 children with unilateral and bilateral cleft lip and palate aged between 4 and 7 years participated in the experiment. The Test of Language Development-Primary, third edition (TOLD-P3) was performed to evaluate the language parameters. The results were scored according to the test manual and compared to normative data published with the TOLD-P3. t test analysis showed a significant difference between language parameters in children with cleft lip and palate and the normative data (p < 0.0001). Furthermore, there was a positive correlation between different aspects of language performance. The findings emphasize that speech-language pathologists should also concentrate on early language assessment and treatment for children with cleft lip and palate. © 2016 S. Karger AG, Basel.

[Primary, single-stage arterial switch operations at a newly-established, comprehensive congenital cardiac center performed in the neonatal age and beyond].

PubMed

Király, László; Tamás, Csaba

2015-06-21

Outcome of arterial switch operation for transposition of the great arteries with/without ventricular septal defect is a service key-performance-indicator. The aim of the authors was to assess patient characteristics and parameters in the perioperative course. In the setting of a newly-established, comprehensive tertiary-care center, primary complete repair was performed including associated anomalies, e.g. transverse arch repairs. Patients with d-transposition were grouped according to coexistence of ventricular septal defect. 118 arterial switch operations were performed between 2007 and 2014 with 96.62% survival (114/118). Ventricular septal defect and repair of associated anomalies did not yield worse outcome. Left ventricular re-training with late presentation necessitated mechanical circulatory support for 4.5±1.5 days. D-transposition is suitable for standardization of clinical algorithm and surgical technique. Quality standards contribute to excellent outcomes, minimize complications, and serve as blueprint for other neonatal open-heart procedures. Availability of mechanical circulatory support is key for single-stage left ventricular re-training beyond the neonatal period.

Analysis of radiological parameters associated with decreased fractional anisotropy values on diffusion tensor imaging in patients with lumbar spinal stenosis.

PubMed

Wang, Xiandi; Wang, Hongli; Sun, Chi; Zhou, Shuyi; Meng, Tao; Lv, Feizhou; Ma, Xiaosheng; Xia, Xinlei; Jiang, Jianyuan

2018-04-26

Previous studies have indicated that decreased fractional anisotropy (FA) values on diffusion tensor imaging (DTI) are well correlated with the symptoms of nerve root compression. The aim of our study is to determine primary radiological parameters associated with decreased FA values in patients with lumbar spinal stenosis involving single L5 nerve root. Patients confirmed with single L5 nerve root compression by transforaminal nerve root blocks were included in this study. FA values of L5 nerve roots on both symptomatic and asymptomatic side were obtained. Conventional radiological parameters, such as disc height, degenerative scoliosis, dural sac cross-sectional area (DSCSA), foraminal height (FH), hypertrophic facet joint degeneration (HFJD), sagittal rotation (SR), sedimentation sign, sagittal translation and traction spur were measured. Correlation and regression analyses were performed between the radiological parameters and FA values of the symptomatic L5 nerve roots. A predictive regression equation was established. Twenty-one patients were included in this study. FA values were significantly lower at the symptomatic side comparing to the asymptomatic side (0.263 ± 0.069 vs. 0.334 ± 0.080, P = 0.038). DSCSA, FH, HFJD, and SR were significantly correlated with the decreased FA values, with r = 0.518, 0.443, 0.472 and - 0.910, respectively (P < 0.05). DSCSA and SR were found to be the primary radiological parameters related to the decreased FA values, and the regression equation is FA = - 0.012 × SR + 0.002 × DSCSA. DSCSA and SR were primary contributors to decreased FA values in LSS patients involving single L5 nerve root, indicating that central canal decompression and segmental stability should be the first considerations in preoperative planning of these patients. These slides can be retrieved under Electronic Supplementary Material.

A Data Mining Approach for Acoustic Diagnosis of Cardiopulmonary Disease

DTIC Science & Technology

2008-06-01

chocolate chip cookies are amazing! This thesis was prepared at The Charles Stark Draper Laboratory, Inc., under Internal Company Research Project 21796...very expensive to perform. New medical technology has been the primary cause for the rising health care costs and insurance premiums. There are two...empirical risk minimization ( ERM ) principle. Generalization error can be minimized by using cross validation to select the best parameters for the

Equilibria of the symmetric collinear restricted four-body problem with radiation pressure

NASA Astrophysics Data System (ADS)

Arribas, M.; Abad, A.; Elipe, A.; Palacios, M.

2016-02-01

In this paper, a restricted four-body problem with radiation pressure is considered. The three primaries are supposed in a collinear central configuration where both masses and both radiation forces of peripheral bodies are equal. After an adequate formulation, the problem is reduced to a tri-parametric one. A complete analysis of the position of equilibria and their stability in the space of parameters is performed.

A physiologically based model for temporal envelope encoding in human primary auditory cortex.

PubMed

Dugué, Pierre; Le Bouquin-Jeannès, Régine; Edeline, Jean-Marc; Faucon, Gérard

2010-09-01

Communication sounds exhibit temporal envelope fluctuations in the low frequency range (<70 Hz) and human speech has prominent 2-16 Hz modulations with a maximum at 3-4 Hz. Here, we propose a new phenomenological model of the human auditory pathway (from cochlea to primary auditory cortex) to simulate responses to amplitude-modulated white noise. To validate the model, performance was estimated by quantifying temporal modulation transfer functions (TMTFs). Previous models considered either the lower stages of the auditory system (up to the inferior colliculus) or only the thalamocortical loop. The present model, divided in two stages, is based on anatomical and physiological findings and includes the entire auditory pathway. The first stage, from the outer ear to the colliculus, incorporates inhibitory interneurons in the cochlear nucleus to increase performance at high stimuli levels. The second stage takes into account the anatomical connections of the thalamocortical system and includes the fast and slow excitatory and inhibitory currents. After optimizing the parameters of the model to reproduce the diversity of TMTFs obtained from human subjects, a patient-specific model was derived and the parameters were optimized to effectively reproduce both spontaneous activity and the oscillatory part of the evoked response. Copyright (c) 2010 Elsevier B.V. All rights reserved.

Poster — Thur Eve — 47: Monte Carlo Simulation of Scp, Sc and Sp

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhan, Lixin; Jiang, Runqing; Osei, Ernest K.

The in-water output ratio (Scp), in-air output ratio (Sc), and phantom scattering factor (Sp) are important parameters for radiotherapy dose calculation. Experimentally, Scp is obtained by measuring the dose rate ratio in water phantom, and Sc the water Kerma rate ratio in air. There is no method that allows direct measurement of Sp. Monte Carlo (MC) method has been used to simulate Scp and Sc in literatures, similar to experimental setup, but no MC direct simulation of Sp available yet to the best of our knowledge. We propose in this report a method of performing direct MC simulation of Sp.more » Starting from the definition, we derived that Sp of a clinical photon beam can be approximated by the ratio of the dose rates contributed from the primary beam for a given field size to the reference field size. Since only the primary beam is used, any Linac head scattering should be excluded from the simulation, which can be realized by using the incident electron as a scoring parameter for MU. We performed MC simulations for Scp, Sc and Sp. Scp matches well with golden beam data. Sp obtained by the proposed method agrees well with what is obtained using the traditional method, Sp=Scp/Sc. Since the smaller the field size, the more the primary beam dominates, our Sp simulation method is accurate for small field. By analyzing the calculated data, we found that this method can be used with no problem for large fields. The difference it introduced is clinically insignificant.« less

WE-EF-207-09: Single-Scan Dual-Energy CT Using Primary Modulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Petrongolo, M; Zhu, L

Purpose: Compared with conventional CT, dual energy CT (DECT) provides better material differentiation but requires projection data with two different effective x-ray spectra. Current DECT scanners use either a two-scan setting or costly imaging components, which are not feasible or available on open-gantry cone-beam CT systems. We propose a hardware-based method which utilizes primary modulation to enable single-scan DECT on a conventional CT scanner. The CT imaging geometry of primary modulation is identical to that used in our previous method for scatter removal, making it possible for future combination with effective scatter correction on the same CT scanner. Methods: Wemore » insert an attenuation sheet with a spatially-varying pattern - primary modulator-between the x-ray source and the imaged object. During the CT scan, the modulator selectively hardens the x-ray beam at specific detector locations. Thus, the proposed method simultaneously acquires high and low energy data. High and low energy CT images are then reconstructed from projections with missing data via an iterative CT reconstruction algorithm with gradient weighting. Proof-of-concept studies are performed using a copper modulator on a cone-beam CT system. Results: Our preliminary results on the Catphan(c) 600 phantom indicate that the proposed method for single-scan DECT is able to successfully generate high-quality high and low energy CT images and distinguish different materials through basis material decomposition. By applying correction algorithms and using all of the acquired projection data, we can reconstruct a single CT image of comparable image quality to conventional CT images, i.e., without primary modulation. Conclusion: This work shows great promise in using a primary modulator to perform high-quality single-scan DECT imaging. Future studies will test method performance on anthropomorphic phantoms and perform quantitative analyses on image qualities and DECT decomposition accuracy. We will use simulations to optimize the modulator material and geometry parameters.« less

The National Football League Scouting Combine from 1999 to 2014: normative reference values and an examination of body mass normalization techniques.

PubMed

Nuzzo, James L

2015-02-01

The primary purpose of this study was to identify the most appropriate method for normalizing physical performance measures to body mass in American football players. Data were obtained from the population of players (n = 4,603) that completed the vertical jump, broad jump, 40-yd sprint, 20-yd shuttle, 3-cone drill, and bench press at the National Football League Scouting Combine from 1999 to 2014. Correlation coefficients were used to assess relationships between body mass and physical performance measures. For the entire group and each playing position, absolute (i.e., non-normalized) performance measures were significantly (p ≤ 0.05) correlated with body mass, indicating that normalization is warranted. Ratio scaling, however, was not appropriate for normalizing most performance measures because it merely reversed (and increased in magnitude) the significant correlations between body mass and performance. Allometric scaling with derived allometric parameters was appropriate for normalizing all performance measures because correlations between body mass and performance were near to zero and no longer statistically significant. However, the derived allometric parameters differed by playing position. Thus, when normalizing physical performance measures to body mass, strength and conditioning professionals should use allometric scaling with test- and position-specific allometric parameters. Additionally, in the current study, percentile rankings were generated to provide test- and position-specific normative reference values for the absolute measures. Until body mass normalization techniques are adopted more broadly, strength and conditioning professionals can use these normative references values to compare current players with those who have already participated in the Scouting Combine.

Prognosis estimation under the light of metabolic tumor parameters on initial FDG-PET/CT in patients with primary extranodal lymphoma

PubMed Central

Okuyucu, Kursat; Ozaydın, Sukru; Alagoz, Engin; Ozgur, Gokhan; Oysul, Fahrettin Guven; Ozmen, Ozlem; Tuncel, Murat; Ozturk, Mustafa; Arslan, Nuri

2016-01-01

Abstract Background Non-Hodgkin’s lymphomas arising from the tissues other than primary lymphatic organs are named primary extranodal lymphoma. Most of the studies evaluated metabolic tumor parameters in different organs and histopathologic variants of this disease generally for treatment response. We aimed to evaluate the prognostic value of metabolic tumor parameters derived from initial FDG-PET/CT in patients with a medley of primary extranodal lymphoma in this study. Patients and methods There were 67 patients with primary extranodal lymphoma for whom FDG-PET/CT was requested for primary staging. Quantitative PET/CT parameters: maximum standardized uptake value (SUVmax), average standardized uptake value (SUVmean), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were used to estimate disease-free survival and overall survival. Results SUVmean, MTV and TLG were found statistically significant after multivariate analysis. SUVmean remained significant after ROC curve analysis. Sensitivity and specificity were calculated as 88% and 64%, respectively, when the cut-off value of SUVmean was chosen as 5.15. After the investigation of primary presentation sites and histo-pathological variants according to recurrence, there is no difference amongst the variants. Primary site of extranodal lymphomas however, is statistically important (p = 0.014). Testis and central nervous system lymphomas have higher recurrence rate (62.5%, 73%, respectively). Conclusions High SUVmean, MTV and TLG values obtained from primary staging FDG-PET/CT are potential risk factors for both disease-free survival and overall survival in primary extranodal lymphoma. SUVmean is the most significant one amongst them for estimating recurrence/metastasis. PMID:27904443

Event-related potentials and secondary task performance during simulated driving.

PubMed

Wester, A E; Böcker, K B E; Volkerts, E R; Verster, J C; Kenemans, J L

2008-01-01

Inattention and distraction account for a substantial number of traffic accidents. Therefore, we examined the impact of secondary task performance (an auditory oddball task) on a primary driving task (lane keeping). Twenty healthy participants performed two 20-min tests in the Divided Attention Steering Simulator (DASS). The visual secondary task of the DASS was replaced by an auditory oddball task to allow recording of brain activity. The driving task and the secondary (distracting) oddball task were presented in isolation and simultaneously, to assess their mutual interference. In addition to performance measures (lane keeping in the primary driving task and reaction speed in the secondary oddball task), brain activity, i.e. event-related potentials (ERPs), was recorded. Performance parameters on the driving test and the secondary oddball task did not differ between performance in isolation and simultaneous performance. However, when both tasks were performed simultaneously, reaction time variability increased in the secondary oddball task. Analysis of brain activity indicated that ERP amplitude (P3a amplitude) related to the secondary task, was significantly reduced when the task was performed simultaneously with the driving test. This study shows that when performing a simple secondary task during driving, performance of the driving task and this secondary task are both unaffected. However, analysis of brain activity shows reduced cortical processing of irrelevant, potentially distracting stimuli from the secondary task during driving.

ACR-SPR-STR Practice Parameter for the Performance of Cardiac Positron Emission Tomography - Computed Tomography (PET/CT) Imaging.

PubMed

Subramaniam, Rathan M; Janowitz, Warren R; Johnson, Geoffrey B; Lodge, Martin A; Parisi, Marguerite T; Ferguson, Mark R; Hellinger, Jeffrey C; Gladish, Gregory W; Gupta, Narainder K

2017-12-01

This clinical practice parameter has been developed collaboratively by the American College of Radiology (ACR), the Society for Pediatric Radiology (SPR), and the Society of Thoracic Radiology (STR). This document is intended to act as a guide for physicians performing and interpreting positron emission tomography-computed tomography (PET/CT) of cardiac diseases in adults and children. The primary value of cardiac PET/CT imaging include evaluation of perfusion, function, viability, inflammation, anatomy, and risk stratification for cardiac-related events such as myocardial infarction and death. Optimum utility of cardiac PET/CT is achieved when images are interpreted in conjunction with clinical information and laboratory data. Measurement of myocardial blood flow, coronary flow reserve and detection of balanced ischemia are significant advantages of cardiac PET perfusion studies. Increasingly cardiac PET/CT is used in diagnosis and treatment response assessment for cardiac sarcoidosis.

Heat treatment study 2

NASA Technical Reports Server (NTRS)

Workman, Gary L.

1990-01-01

The microstructural variations in nickel based superalloys that result from modifications in processing were examined. These superalloys include MAR-M246(HF) and PWA1480. Alternate heat treatments for equiaxed as-cast specimens were studied and a sample matrix of 42 variations in the heat treatments were processed, as well as different directional solidification parameters. Variation in temperature and times for both solution and aging were performed. Photomicrographs were made of the microstructure and volume fraction analysis of primary gamma-prime and aged gamma-prime precipitates were performed. The results of the heat treatment, cooling rate, and directional solidification experiments are discussed.

Rachis morphology cannot accurately predict the mechanical performance of primary feathers in extant (and therefore fossil) feathered flyers

NASA Astrophysics Data System (ADS)

Lees, John; Garner, Terence; Cooper, Glen; Nudds, Robert

2017-02-01

It was previously suggested that the flight ability of feathered fossils could be hypothesized from the diameter of their feather rachises. Central to the idea is the unvalidated assumption that the strength of a primary flight feather (i.e. its material and structural properties) may be consistently calculated from the external diameter of the feather rachis, which is the only dimension that is likely to relate to structural properties available from fossils. Here, using three-point bending tests, the relationship between feather structural properties (maximum bending moment, Mmax and Young's modulus, Ebend) and external morphological parameters (primary feather rachis length, diameter and second moment of area at the calamus) in 180 primary feathers from four species of bird of differing flight style was investigated. Intraspecifically, both Ebend and Mmax were strongly correlated with morphology, decreasing and increasing, respectively, with all three morphological measures. Without accounting for species, however, external morphology was a poor predictor of rachis structural properties, meaning that precise determination of aerial performance in extinct, feathered species from external rachis dimensions alone is not possible. Even if it were possible to calculate the second moment of area of the rachis, our data suggest that feather strength could still not be reliably estimated.

A computer model for liquid jet atomization in rocket thrust chambers

NASA Astrophysics Data System (ADS)

Giridharan, M. G.; Lee, J. G.; Krishnan, A.; Yang, H. Q.; Ibrahim, E.; Chuech, S.; Przekwas, A. J.

1991-12-01

The process of atomization has been used as an efficient means of burning liquid fuels in rocket engines, gas turbine engines, internal combustion engines, and industrial furnaces. Despite its widespread application, this complex hydrodynamic phenomenon has not been well understood, and predictive models for this process are still in their infancy. The difficulty in simulating the atomization process arises from the relatively large number of parameters that influence it, including the details of the injector geometry, liquid and gas turbulence, and the operating conditions. In this study, numerical models are developed from first principles, to quantify factors influencing atomization. For example, the surface wave dynamics theory is used for modeling the primary atomization and the droplet energy conservation principle is applied for modeling the secondary atomization. The use of empirical correlations has been minimized by shifting the analyses to fundamental levels. During applications of these models, parametric studies are performed to understand and correlate the influence of relevant parameters on the atomization process. The predictions of these models are compared with existing experimental data. The main tasks of this study were the following: development of a primary atomization model; development of a secondary atomization model; development of a model for impinging jets; development of a model for swirling jets; and coupling of the primary atomization model with a CFD code.

On the Study of Cognitive Bidirectional Relaying with Asymmetric Traffic Demands

NASA Astrophysics Data System (ADS)

Ji, Xiaodong

2015-05-01

In this paper, we consider a cognitive radio network scenario, where two primary users want to exchange information with each other and meanwhile, one secondary node wishes to send messages to a cognitive base station. To meet the target quality of service (QoS) of the primary users and raise the communication opportunity of the secondary nodes, a cognitive bidirectional relaying (BDR) scheme is examined. First, system outage probabilities of conventional direct transmission and BDR schemes are presented. Next, a new system parameter called operating region is defined and calculated, which indicates in which position a secondary node can be a cognitive relay to assist the primary users. Then, a cognitive BDR scheme is proposed, giving a transmission protocol along with a time-slot splitting algorithm between the primary and secondary transmissions. Information-theoretic metric of ergodic capacity is studied for the cognitive BDR scheme to evaluate its performance. Simulation results show that with the proposed scheme, the target QoS of the primary users can be guaranteed, while increasing the communication opportunity for the secondary nodes.

Characterization of cognitive and motor performance during dual-tasking in healthy older adults and patients with Parkinson's disease.

PubMed

Wild, Lucia Bartmann; de Lima, Daiane Borba; Balardin, Joana Bisol; Rizzi, Luana; Giacobbo, Bruno Lima; Oliveira, Henrique Bianchi; de Lima Argimon, Irani Iracema; Peyré-Tartaruga, Leonardo Alexandre; Rieder, Carlos R M; Bromberg, Elke

2013-02-01

The primary purpose of this study was to investigate the effect of dual-tasking on cognitive performance and gait parameters in patients with idiopathic Parkinson's disease (PD) without dementia. The impact of cognitive task complexity on cognition and walking was also examined. Eighteen patients with PD (ages 53-88, 10 women; Hoehn and Yahr stage I-II) and 18 older adults (ages 61-84; 10 women) completed two neuropsychological measures of executive function/attention (the Stroop Test and Wisconsin Card Sorting Test). Cognitive performance and gait parameters related to functional mobility of stride were measured under single (cognitive task only) and dual-task (cognitive task during walking) conditions with different levels of difficulty and different types of stimuli. In addition, dual-task cognitive costs were calculated. Although cognitive performance showed no significant difference between controls and PD patients during single or dual-tasking conditions, only the patients had a decrease in cognitive performance during walking. Gait parameters of patients differed significantly from controls at single and dual-task conditions, indicating that patients gave priority to gait while cognitive performance suffered. Dual-task cognitive costs of patients increased with task complexity, reaching significantly higher values then controls in the arithmetic task, which was correlated with scores on executive function/attention (Stroop Color-Word Page). Baseline motor functioning and task executive/attentional load affect the performance of cognitive tasks of PD patients while walking. These findings provide insight into the functional strategies used by PD patients in the initial phases of the disease to manage dual-task interference.

Uncertainty analysis as essential step in the establishment of the dynamic Design Space of primary drying during freeze-drying.

PubMed

Mortier, Séverine Thérèse F C; Van Bockstal, Pieter-Jan; Corver, Jos; Nopens, Ingmar; Gernaey, Krist V; De Beer, Thomas

2016-06-01

Large molecules, such as biopharmaceuticals, are considered the key driver of growth for the pharmaceutical industry. Freeze-drying is the preferred way to stabilise these products when needed. However, it is an expensive, inefficient, time- and energy-consuming process. During freeze-drying, there are only two main process variables to be set, i.e. the shelf temperature and the chamber pressure, however preferably in a dynamic way. This manuscript focuses on the essential use of uncertainty analysis for the determination and experimental verification of the dynamic primary drying Design Space for pharmaceutical freeze-drying. Traditionally, the chamber pressure and shelf temperature are kept constant during primary drying, leading to less optimal process conditions. In this paper it is demonstrated how a mechanistic model of the primary drying step gives the opportunity to determine the optimal dynamic values for both process variables during processing, resulting in a dynamic Design Space with a well-known risk of failure. This allows running the primary drying process step as time efficient as possible, hereby guaranteeing that the temperature at the sublimation front does not exceed the collapse temperature. The Design Space is the multidimensional combination and interaction of input variables and process parameters leading to the expected product specifications with a controlled (i.e., high) probability. Therefore, inclusion of parameter uncertainty is an essential part in the definition of the Design Space, although it is often neglected. To quantitatively assess the inherent uncertainty on the parameters of the mechanistic model, an uncertainty analysis was performed to establish the borders of the dynamic Design Space, i.e. a time-varying shelf temperature and chamber pressure, associated with a specific risk of failure. A risk of failure acceptance level of 0.01%, i.e. a 'zero-failure' situation, results in an increased primary drying process time compared to the deterministic dynamic Design Space; however, the risk of failure is under control. Experimental verification revealed that only a risk of failure acceptance level of 0.01% yielded a guaranteed zero-defect quality end-product. The computed process settings with a risk of failure acceptance level of 0.01% resulted in a decrease of more than half of the primary drying time in comparison with a regular, conservative cycle with fixed settings. Copyright © 2016. Published by Elsevier B.V.

COHERENT NETWORK ANALYSIS FOR CONTINUOUS GRAVITATIONAL WAVE SIGNALS IN A PULSAR TIMING ARRAY: PULSAR PHASES AS EXTRINSIC PARAMETERS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Yan; Mohanty, Soumya D.; Jenet, Fredrick A., E-mail: ywang12@hust.edu.cn

2015-12-20

Supermassive black hole binaries are one of the primary targets of gravitational wave (GW) searches using pulsar timing arrays (PTAs). GW signals from such systems are well represented by parameterized models, allowing the standard Generalized Likelihood Ratio Test (GLRT) to be used for their detection and estimation. However, there is a dichotomy in how the GLRT can be implemented for PTAs: there are two possible ways in which one can split the set of signal parameters for semi-analytical and numerical extremization. The straightforward extension of the method used for continuous signals in ground-based GW searches, where the so-called pulsar phasemore » parameters are maximized numerically, was addressed in an earlier paper. In this paper, we report the first study of the performance of the second approach where the pulsar phases are maximized semi-analytically. This approach is scalable since the number of parameters left over for numerical optimization does not depend on the size of the PTA. Our results show that for the same array size (9 pulsars), the new method performs somewhat worse in parameter estimation, but not in detection, than the previous method where the pulsar phases were maximized numerically. The origin of the performance discrepancy is likely to be in the ill-posedness that is intrinsic to any network analysis method. However, the scalability of the new method allows the ill-posedness to be mitigated by simply adding more pulsars to the array. This is shown explicitly by taking a larger array of pulsars.« less

Evaluation of a pneumatic boot deicing system on a general aviation wing model

NASA Technical Reports Server (NTRS)

Albright, A. E.; Kohlman, D. L.; Schweikhard, W. G.; Evanich, P.

1981-01-01

The aerodynamic characteristics of a typical modern general aviation airfoil were investigated with and without a pneumatic boot ice protection system. The ice protection effectiveness of the boot was studied. This includes the change in drag on the airfoil with the boot inflated and deflated, the change in drag due to primary and residual ice formation, drag change due to cumulative residual ice formation, and parameters affecting boot effectiveness. Boot performance was not affected by tunnel total temperature or velocity. Marginal effect in performance was associated with angle of attack. Significant effects on performance were caused by variations in droplet size, LWC, ice cap thickness inflation pressure, and surface treatment.

Identifying key sources of uncertainty in the modelling of greenhouse gas emissions from wastewater treatment.

PubMed

Sweetapple, Christine; Fu, Guangtao; Butler, David

2013-09-01

This study investigates sources of uncertainty in the modelling of greenhouse gas emissions from wastewater treatment, through the use of local and global sensitivity analysis tools, and contributes to an in-depth understanding of wastewater treatment modelling by revealing critical parameters and parameter interactions. One-factor-at-a-time sensitivity analysis is used to screen model parameters and identify those with significant individual effects on three performance indicators: total greenhouse gas emissions, effluent quality and operational cost. Sobol's method enables identification of parameters with significant higher order effects and of particular parameter pairs to which model outputs are sensitive. Use of a variance-based global sensitivity analysis tool to investigate parameter interactions enables identification of important parameters not revealed in one-factor-at-a-time sensitivity analysis. These interaction effects have not been considered in previous studies and thus provide a better understanding wastewater treatment plant model characterisation. It was found that uncertainty in modelled nitrous oxide emissions is the primary contributor to uncertainty in total greenhouse gas emissions, due largely to the interaction effects of three nitrogen conversion modelling parameters. The higher order effects of these parameters are also shown to be a key source of uncertainty in effluent quality. Copyright © 2013 Elsevier Ltd. All rights reserved.

Adaptively Tuned Iterative Low Dose CT Image Denoising

PubMed Central

Hashemi, SayedMasoud; Paul, Narinder S.; Beheshti, Soosan; Cobbold, Richard S. C.

2015-01-01

Improving image quality is a critical objective in low dose computed tomography (CT) imaging and is the primary focus of CT image denoising. State-of-the-art CT denoising algorithms are mainly based on iterative minimization of an objective function, in which the performance is controlled by regularization parameters. To achieve the best results, these should be chosen carefully. However, the parameter selection is typically performed in an ad hoc manner, which can cause the algorithms to converge slowly or become trapped in a local minimum. To overcome these issues a noise confidence region evaluation (NCRE) method is used, which evaluates the denoising residuals iteratively and compares their statistics with those produced by additive noise. It then updates the parameters at the end of each iteration to achieve a better match to the noise statistics. By combining NCRE with the fundamentals of block matching and 3D filtering (BM3D) approach, a new iterative CT image denoising method is proposed. It is shown that this new denoising method improves the BM3D performance in terms of both the mean square error and a structural similarity index. Moreover, simulations and patient results show that this method preserves the clinically important details of low dose CT images together with a substantial noise reduction. PMID:26089972

Impact of a Pharmacy-Cardiology Collaborative Practice on Dofetilide Safety Monitoring.

PubMed

Quffa, Lieth H; Panna, Mark; Kaufmann, Michael R; McKillop, Matthew; Dietrich, Nicole Maltese; Franck, Andrew J

2017-01-01

Limited studies have been published examining dofetilide's postmarketing use and its recommended monitoring. To evaluate the impact of a collaborative pharmacy-cardiology antiarrhythmic drug (AAD) monitoring program on dofetilide monitoring. This retrospective cohort study was performed to assess if a novel monitoring program improved compliance with dofetilide-specific monitoring parameters based on the Food and Drug Administration's Risk Evaluation and Mitigation Strategy. A total of 30 patients were included in the analysis. The monitoring parameters evaluated included electrocardiogram, serum potassium, serum magnesium, and kidney function. The primary outcome evaluated was the composite of these dofetilide monitoring parameters obtained in each cohort. In the standard cohort, 245 of 352 (69.6%) monitoring parameters were completed versus 134 of 136 (98.5%) in the intervention group ( P < 0.05). A collaborative pharmacy-cardiology AAD monitoring program was associated with a significant improvement in dofetilide monitoring. This improvement could potentially translate into enhanced patient safety outcomes, such as prevention of adverse drug reactions and decreased hospitalizations.

Parameter-based estimation of CT dose index and image quality using an in-house android™-based software

NASA Astrophysics Data System (ADS)

Mubarok, S.; Lubis, L. E.; Pawiro, S. A.

2016-03-01

Compromise between radiation dose and image quality is essential in the use of CT imaging. CT dose index (CTDI) is currently the primary dosimetric formalisms in CT scan, while the low and high contrast resolutions are aspects indicating the image quality. This study was aimed to estimate CTDIvol and image quality measures through a range of exposure parameters variation. CTDI measurements were performed using PMMA (polymethyl methacrylate) phantom of 16 cm diameter, while the image quality test was conducted by using catphan ® 600. CTDI measurements were carried out according to IAEA TRS 457 protocol using axial scan mode, under varied parameters of tube voltage, collimation or slice thickness, and tube current. Image quality test was conducted accordingly under the same exposure parameters with CTDI measurements. An Android™ based software was also result of this study. The software was designed to estimate the value of CTDIvol with maximum difference compared to actual CTDIvol measurement of 8.97%. Image quality can also be estimated through CNR parameter with maximum difference to actual CNR measurement of 21.65%.

The Effects of Phacoemulsification and Intraocular Lens Implantation on Anatomical and Functional Parameters in Patients with Primary Angle Closure: A Prospective Study. (An American Ophthalmological Society Thesis).

PubMed

Traverso, Carlo Enrico; Cutolo, Carlo Alberto

2017-08-01

To investigate the clinical, anatomical, and patient-reported outcomes of phacoemulsification (PE) with intraocular lens implantation performed to treat primary angle closure (PAC) and primary angle-closure glaucoma (PACG). Patients were evaluated at baseline and at 6 months after PE. The examination included visual acuity, intraocular pressure (IOP), visual field, optic nerve head, endothelial cell count (ECC), aqueous depth, and ocular biometric parameters. Patient-reported visual function and health status were assessed. Coprimary outcome measures were IOP changes, angle widening, and patient-reported visual function; secondary outcome measures were visual acuity changes, use of IOP-lowering medications, and complications. Univariate and multivariate analyses were performed to determine the predictors of IOP change. Thirty-nine cases were identified, and postoperative data were analyzed for 59 eyes, 39 with PACG and 20 with PAC. Globally, PE resulted in a mean reduction in IOP of -6.33 mm Hg (95% CI, -8.64 to -4.01, P <.001). Aqueous depth and angle measurements improved ( P <.01), whereas ECC significantly decreased ( P <.001). Both corrected and uncorrected visual acuity improved ( P <.01). The EQ visual analog scale did not change ( P =.16), but VFQ-25 improved ( P <.01). The IOP-lowering effect of PE was greater in the PACG compared to the PAC group ( P =.04). In both groups, preoperative IOP was the most significant predictor of IOP change ( P <.01). No sight-threatening complications were recorded. Our data support the usefulness of PE in lowering the IOP in patients with PAC and PACG. Although PE resulted in several anatomical and patient-reported visual improvements, we observe that a marked decrease in ECC should be carefully weighed before surgery.

Neural Networks for Nodal Staging of Non–Small Cell Lung Cancer with FDG PET and CT: Importance of Combining Uptake Values and Sizes of Nodes and Primary Tumor

PubMed Central

Vesselle, Hubert J.

2014-01-01

Purpose To evaluate the effect of adding lymph node size to three previously explored artificial neural network (ANN) input parameters (primary tumor maximum standardized uptake value or tumor uptake, tumor size, and nodal uptake at N1, N2, and N3 stations) in the structure of the ANN. The goal was to allow the resulting ANN structure to relate lymph node uptake for size to primary tumor uptake for size in the determination of the status of nodes as human readers do. Materials and Methods This prospective study was approved by the institutional review board, and informed consent was obtained from all participants. The authors developed a back-propagation ANN with one hidden layer and eight processing units. The data set used to train the network included node and tumor size and uptake from 133 patients with non–small cell lung cancer with surgically proved N status. Statistical analysis was performed with the paired t test. Results The ANN correctly predicted the N stage in 99.2% of cases, compared with 72.4% for the expert reader (P < .001). In categorization of N0 and N1 versus N2 and N3 disease, the ANN performed with 99.2% accuracy versus 92.2% for the expert reader (P < .001). Conclusion The ANN is 99.2% accurate in predicting surgical-pathologic nodal status with use of four fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT)–derived parameters. Malignant and benign inflammatory lymph nodes have overlapping appearances at FDG PET/CT but can be differentiated by ANNs when the crucial input of node size is used. © RSNA, 2013 Online supplemental material is available for this article. PMID:24056403

Long-term passive restoration following fluvial deposition of sulphidic copper tailings: nature filters out the solutions.

PubMed

Nikolic, Nina; Böcker, Reinhard; Nikolic, Miroslav

2016-07-01

Despite the growing popularity of ecological restoration approach, data on primary succession on toxic post-mining substrates, under site environmental conditions which considerably differ from the surrounding environment, are still scarce. Here, we studied the spontaneous vegetation development on an unusual locality created by long-term and large-scale fluvial deposition of sulphidic tailings from a copper mine in a pronouncedly xerothermic, calcareous surrounding. We performed multivariate analyses of soil samples (20 physical and chemical parameters) and vegetation samples (floristic and structural parameters in three types of occurring forests), collected along the pollution gradients throughout the affected floodplain. The nature can cope with two types of imposed constraints: (a) excessive Cu concentrations and (b) very low pH, combined with nutrient deficiency. The former will still allow convergence to the original vegetation, while the latter will result in novel, depauperate assemblages of species typical for cooler and moister climate. Our results for the first time demonstrate that with the increasing severity of environmental filtering, the relative importance of the surrounding vegetation for primary succession strongly decreases.

Modeling Test and Treatment Strategies for Presymptomatic Alzheimer Disease

PubMed Central

Burke, James F.; Langa, Kenneth M.; Hayward, Rodney A.; Albin, Roger L.

2014-01-01

Objectives In this study, we developed a model of presymptomatic treatment of Alzheimer disease (AD) after a screening diagnostic evaluation and explored the circumstances required for an AD prevention treatment to produce aggregate net population benefit. Methods Monte Carlo simulation methods were used to estimate outcomes in a simulated population derived from data on AD incidence and mortality. A wide variety of treatment parameters were explored. Net population benefit was estimated in aggregated QALYs. Sensitivity analyses were performed by individually varying the primary parameters. Findings In the base-case scenario, treatment effects were uniformly positive, and net benefits increased with increasing age at screening. A highly efficacious treatment (i.e. relative risk 0.6) modeled in the base-case is estimated to save 20 QALYs per 1000 patients screened and 221 QALYs per 1000 patients treated. Conclusions Highly efficacious presymptomatic screen and treat strategies for AD are likely to produce substantial aggregate population benefits that are likely greater than the benefits of aspirin in primary prevention of moderate risk cardiovascular disease (28 QALYS per 1000 patients treated), even in the context of an imperfect treatment delivery environment. PMID:25474698

Prognostic impact of intestinal wall thickening in hospitalized patients with heart failure.

PubMed

Ikeda, Yuki; Ishii, Shunsuke; Fujita, Teppei; Iida, Yuichiro; Kaida, Toyoji; Nabeta, Takeru; Maekawa, Emi; Yanagisawa, Tomoyoshi; Koitabashi, Toshimi; Takeuchi, Ichiro; Inomata, Takayuki; Ako, Junya

2017-03-01

Intestine-cardiovascular relationship has been increasingly recognized as a key factor in patients with heart disease. We aimed to identify the relationships among intestinal wall edema, cardiac function, and adverse clinical events in hospitalized heart failure (HF) patients. Abdominal computed tomographic images of 168 hospitalized HF patients were retrospectively investigated for identification of average colon wall thickness (CWT) from the ascending to sigmoid colon. Relationships between average CWT and echocardiographic parameters, blood sampling data, and primary outcomes including readmission for deteriorated HF and all-cause mortality were evaluated. Among the echocardiographic parameters, lower left ventricular diastolic function was correlated with higher average CWT. In multivariate analysis, higher logarithmic C-reactive protein level, lower estimated glomerular filtration rate, lower peripheral blood lymphocyte count, higher E/E' ratio, and extremely higher/lower defecation frequency were independently correlated with higher average CWT. Multivariate Cox-hazard analysis demonstrated that higher average CWT was independently related to higher incidence of primary outcomes. In hospitalized HF patients, increased CWT was associated with lower cardiac performance, and predicted poorer long-term clinical outcomes. Copyright © 2016. Published by Elsevier B.V.

Performance Evaluation of the ISS Water Processor Multifiltration Beds

NASA Technical Reports Server (NTRS)

Bowman, Elizabeth M.; Carter, Layne; Wilson, Mark; Cole, Harold; Orozco, Nicole; Snowdon, Doug

2012-01-01

The ISS Water Processor Assembly (WPA) produces potable water from a waste stream containing humidity condensate and urine distillate. The primary treatment process is achieved in the Multifiltration Bed, which includes adsorbent media and ion exchange resin for the removal of dissolved organic and inorganic contaminants. The first Multifiltration Bed was replaced on ISS in July 2010 after initial indication of inorganic breakthrough. This bed was returned to ground in July 2011 for an engineering investigation. The water resident in the bed was analyzed for various parameters to evaluate adsorbent loading, performance of the ion exchange resin, microbial activity, and generation of leachates from the ion exchange resin. Portions of the adsorbent media and ion exchange resin were sampled and subsequently desorbed to identify the primary contaminants removed at various points in the bed. In addition, an unused Multifiltration Bed was evaluated after two years in storage to assess the generation of leachates during storage. This assessment was performed to evaluate the possibility that these leachates are impacting performance of the Catalytic Reactor located downstream of the Multifiltration Bed. The results of these investigations and implications to the operation of the WPA on ISS are documented in this paper.

Active feedforward noise control and signal tracking of headsets: Electroacoustic analysis and system implementation.

PubMed

Bai, Mingsian R; Pan, Weichi; Chen, Hungyu

2018-03-01

Active noise control (ANC) of headsets is revisited in this paper. An in-depth electroacoustic analysis of the combined loudspeaker-cavity headset system is conducted on the basis of electro-mechano-acoustical analogous circuits. Model matching of the primary path and the secondary path leads to a feedforward control architecture. The ideal controller sheds some light on the key parameters that affect the noise reduction performance. Filtered-X least-mean-squares algorithm is employed to implement the feedforward controller on a digital signal processor. Since the relative delay of the primary path and the secondary path is crucial to the noise reduction performance, multirate signal processing with polyphase implementation is utilized to minimize the effective analog-digital conversion delay in the secondary path. Ad hoc decimation and interpolation filters are designed in order not to introduce excessive phase delays at the cutoff. Real-time experiments are undertaken to validate the implemented ANC system. Listening tests are also conducted to compare the fixed controller and the adaptive controller in terms of noise reduction and signal tracking performance for three noise types. The results have demonstrated that the fixed feedforward controller achieved satisfactory noise reduction performance and signal tracking quality.

Study for analysis of benefit versus cost of low thrust propulsion system

NASA Technical Reports Server (NTRS)

Hamlyn, K. M.; Robertson, R. I.; Rose, L. J.

1983-01-01

The benefits and costs associated with placing large space systems (LSS) in operational orbits were investigated, and a flexible computer model for analyzing these benefits and costs was developed. A mission model for LSS was identified that included both NASA/Commercial and DOD missions. This model included a total of 68 STS launches for the NASA/Commercial missions and 202 launches for the DOD missions. The mission catalog was of sufficient depth to define the structure type, mass and acceleration limits of each LSS. Conceptual primary propulsion stages (PPS) designs for orbital transfer were developed for three low thrust LO2/LH2 engines baselined for the study. The performance characteristics for each of these PPS was compared to the LSS mission catalog to create a mission capture. The costs involved in placing the LSS in their operational orbits were identified. The two primary costs were that of the PPS and of the STS launch. The cost of the LSS was not included as it is not a function of the PPS performance. The basic relationships and algorithms that could be used to describe the costs were established. The benefit criteria for the mission model were also defined. These included mission capture, reliability, technical risk, development time, and growth potential. Rating guidelines were established for each parameter. For flexibility, each parameter is assigned a weighting factor.

PubMed Central

SARTINI, M.; PANATTO, D.; PERDELLI, F.; CRISTINA, M.L.

2013-01-01

Summary An experimental study was conducted in a hospital in Liguria (northern Italy) on two groups of patients with the same disease severity who were undergoing the same type of surgery (primary hemiarthroplasty). Our aim was to assessing the results of a quality- improvement scheme implemented in the operating room. The quality-improvement protocol involved analyzing a set of parameters concerning the operating team's behavior and environmental conditions that could be attributed to the operating team itself. A program of training and sanitary education was carried to rectify any improper behavior of the operating staff. Two hundred and six hip-joint replacement operations (primary hip hemiarthroplasty - ICD9-CM 81.51) all conducted in the same operating room were studied: 103 patients, i.e. operations performed before the quality-improvement scheme and 103 patients, i.e. operations performed after the quality improvement scheme; all were comparable in terms of type of surgery and severity. The scheme resulted in an improvement in both behavioral and environmental parameters and an 80% reduction in the level of microbial air contamination (p < 0.001). Patient outcomes improved in terms of average postoperative hospitalization time, the occurrence and duration of fever (>37.5°C) and microbiological contamination of surgical wounds. From an economic point of view, facility efficiency increased by 28.57%, average hospitalization time decreased (p<0.001) and a theoretical increase of € 1,441,373.58 a year in revenues was achieved. PMID:24396985

Modeling the optical radiation of the precataclysmic variable SDSS J212531-010745

NASA Astrophysics Data System (ADS)

Shimansky, V. V.; Borisov, N. V.; Nurtdinova, D. N.; Solovyeva, Yu. N.; Sakhibullin, N. A.; Spiridonova, O. I.

2015-03-01

Optical observations are analyzed to derive a set of basic parameters for the precataclysmic variable star SDSS J212531-010745, whose primary is a PG1159-type star. Spectroscopic and multiband photometric observations of the star were performed in 2008-2011 with the 6-m telescope and the Zeiss-1000 telescope of the Special Astrophysical Observatory. The shape of the binary's orbital light curves is nearly sinusoidal, with the amplitude increasing with wavelength from Δ m = 0.40 m in the B band to Δ m = 0.73 m in the R band. The spectra contain absorption lines of HeII and neutral atoms, along with HI, HeI, CII, MgII, FeII emission lines, whose intensity increases synchronously with the brightness of the system. The optical radiation from SDSS J212531-010745 has a composite nature, corresponding to a model for a pre-cataclysmic variable with strong reflection effects. Cross-correlation techniques are used to measure the radial velocities and derive the component masses. Numerical modeling of the binary's light curves, radial velocities, and spectra is performed, and a complete set of parameters determined. Considerable abundance anomalies (to 1 dex) were detected for the secondary. The primary's characteristics correspond to the evolutionary predictions for DAO dwarfs with masses M ≈ 0.5 M ⊙, and the secondary's characteristics to low-mass, main-sequence stars with the solar metallicity.

Multifocal electroretinogram (MFERG) evaluation of laser-induced secondary damage in the non-human primate (NHP)

NASA Astrophysics Data System (ADS)

Zwick, Harry; Stuck, Bruce E.; Akers, A.; Edsall, Peter; DiCarlo, Cheryl D.; Lund, David J.

2005-04-01

Laser induced retinal damage may involve primary injury to the central retina and secondary damage, including intraretinal scar formation (IRSF) retinal traction (RT) and retinal nerve fiber layer injury (RNFL). We have evaluated these laser induced retinal pathologies with MFERG in non-human primates (NHPs) with a Veris (4.9) MFERG system 103 Hexagons, centered on the macula with non-scaled arrays and in one NHP with a 2-frame/M-step sequence to assess long term exposure effects within the RNFL. Chemical restraint was achieved using Ketamine stability HCL (10 mg/kg IM) and Propofol (0.5 mg-1.2/Kg/min via syringe pump). Peribulbar eye blocks were performed using 2% lidocain or a mixture of 2% Lidocain/Marcain (monitored ocular motility was less than 40 microns in retinal space). Primary and secondary damage effects were induced with either q-switched single pulse Neodymium (1064 nm, 1.0 mJ) or Argon CW (10 to 1000 msec, 10-150 mW). MFERG demonstrated capability to detect primary and secondary induced retinal damage in both 1st and 2nd order kernels. Primary and secondary damage in the central retina was often suppressed in amplitude and with longer latencies relative to the MFERG norm. Preliminary investigations in one NHP with Primary and secondary RNFL damage at 9 to 14 months showed recovery with non-scaled array one frame / M-step sequence but demonstrated significant abnormalities for a two frame/ M-step sequence. Utilization of advanced Veris recording parameters involving spatial and temporal manipulation of the stimulus parameters can improve detection of functional deficits induced by focal laser retinal injury.

The effects of deposition parameters on surface morphology and crystallographic orientation of electroless Ni-B coatings

NASA Astrophysics Data System (ADS)

Bulbul, Ferhat

2011-02-01

Electroless Ni-B coatings were deposited on AISI 304 stainless steels by electroless deposition method, which was performed for nine different test conditions at various levels of temperature, concentration of NaBH4, concentration of NiCl2, and time, using the Taguchi L9(34) experimental method. The effects of deposition parameters on the crystallographic orientation of electroless Ni-B coatings were investigated using SEM and XRD equipment. SEM analysis revealed that the Ni-B coatings developed six types (pea-like, maize-like, primary nodular, blackberry-like or grapes-like, broccoli-like, and cauliflower-like) of morphological structures depending on the deposition parameters. XRD results also showed that these structures exhibited different levels of amorphous character. The concentration of NaBH4 had the most dominant effect on the morphological and crystallographic development of electroless Ni-B coatings.

The Large Deployable Reflector (LDR) - Plans and progress

NASA Technical Reports Server (NTRS)

Swanson, Paul N.

1987-01-01

The program history, scientific aims, design, and projected performance of the LDR, a 20-m-primary two-stage four-mirror orbiting sub-mm/FIR astronomical observatory under NASA development, are reviewed. It is shown that the LDR would provide capabilities complementary to those of IRAS, the Kuiper Airborne Observatory, the IRTF, the Hubble Space Telescope, and the planned Space IR Telescope Facility for observations of small-scale background anisotropies, high-redshift galaxies, and objects at temperatures of a few times 10 K or lower. The current design concept is illustrated with extensive drawings, diagrams, and tables of instrument parameters. Particular attention is given to the graphite-epoxy facing and Al-honeycomb core of the primary structure, the focal-plane instruments, and outstanding technological problems.

MOLECULAR DYNAMICS OF CASCADES OVERLAP IN TUNGSTEN WITH 20-KEV PRIMARY KNOCK-ON ATOMS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Setyawan, Wahyu; Nandipati, Giridhar; Roche, Kenneth J.

2015-04-16

Molecular dynamics simulations are performed to investigate the mutual influence of two subsequent cascades in tungsten. The influence is studied using 20-keV primary knock-on atoms, to induce one cascade after another separated by 15 ps, in a lattice temperature of 1025 K (i.e. 0.25 of the melting temperature of the interatomic potential). The center of mass of the vacancies at the peak damage during the cascade is taken as the location of the cascade. The distance between this location to that of the next cascade is taken as the overlap parameter. Empirical fits describing the number of surviving vacancies andmore » interstitial atoms as a function of overlap are presented.« less

Evaluation of the removal of Strontium-90 from groundwater using a zeolite rich-rock permeable treatment wall

NASA Astrophysics Data System (ADS)

Seneca, S. M.; Rabideau, A. J.; Bandilla, K.

2010-12-01

Experimental and modeling studies are in progress to evaluate the long-term performance of a permeable treatment wall comprised of zeolite-rich rock for the removal of strontium-90 from groundwater. Multiple column tests were performed at the University at Buffalo and on-site West Valley Environmental Services; columns were supplied with synthetic groundwater referenced to anticipate field conditions and radioactive groundwater on-site WVES. The primary focus in this work is on quantifying the competitive ion exchange among five cations (Na+, K+, Ca2+, Mg2+, and Sr2+); the data obtained from the column studies is used to support the robust estimation of zeolite cation exchange parameters. This research will produce a five-solute cation exchange model describing the removal efficiency of the zeolite, using the various column tests to calibrate and validate the geochemical transport model. The field-scale transport model provides flexibility to explore design parameters and potential variations in groundwater geochemistry to investigate the long-term performance of a full scale treatment wall at the Western New York nuclear facility.

Advanced ovarian cancer: multiparametric MR imaging demonstrates response- and metastasis-specific effects.

PubMed

Sala, Evis; Kataoka, Masako Y; Priest, Andrew N; Gill, Andrew B; McLean, Mary A; Joubert, Ilse; Graves, Martin J; Crawford, Robin A F; Jimenez-Linan, Mercedes; Earl, Helena M; Hodgkin, Charlotte; Griffiths, John R; Lomas, David J; Brenton, James D

2012-04-01

To investigate the role of multiparametric magnetic resonance (MR) imaging in the evaluation of response to platinum-based neoadjuvant chemotherapy in advanced ovarian cancer and to compare imaging parameters between primary ovarian mass and metastatic disease. Evaluable patients suspected of having advanced ovarian carcinoma were enrolled in a prospective protocol-driven study. Research ethics committee approval and written informed consent were obtained. Multiparametric MR imaging (diffusion-weighted MR imaging, dynamic contrast material-enhanced [DCE] MR imaging, and hydrogen 1 MR spectroscopy) was performed with a 3.0-T wholebody MR imaging system. Three marker lesions-primary ovarian mass, omental cake, and peritoneal deposit-were outlined by a radiologist on apparent diffusion coefficient (ADC) and vascular signal fraction (VSF) maps and on DCE MR images. Comparisons of mean ADC, mean VSF, DCE MR imaging parameters, and choline concentration between responders and nonresponders were based on Response Evaluation Criteria in Solid Tumors and CA-125 criteria. Twenty-two patients were evaluable. The mean ADC for peritoneal metastases was lower than that for ovarian (P = .015) and omental (P = .006) sites. There were no differences in pretreatment DCE MR imaging parameters between tumor sites. After treatment, responders showed a significantly larger increase in ADC (P = .021) and fractional volume of the extravascular extracellular space (v(e)) (P = .025) of ovarian lesions compared with nonresponders, but there was no change in ADC at other sites. Pre- and posttreatment values of choline concentration of ovarian lesions were lower in responders (P = .025) than in nonresponders (P = .010). The significant differences in baseline ADCs among primary ovarian cancer, omental cake, and peritoneal deposits indicate that diffusivity profiles may be tumor-site dependent, suggesting biologic heterogeneity of disease. ADC and v(e) parameters correlated with the cytotoxic effects of platinum-based therapy and may be useful response markers, while choline concentration predicted but did not reflect response. © RSNA, 2012.

Preliminary simulation of an advanced, hingless rotor XV-15 tilt-rotor aircraft

NASA Technical Reports Server (NTRS)

Mcveigh, M. A.

1976-01-01

The feasibility of the tilt-rotor concept was verified through investigation of the performance, stability and handling qualities of the XV-15 tilt rotor. The rotors were replaced by advanced-technology fiberglass/composite hingless rotors of larger diameter, combined with an advanced integrated fly-by-wire control system. A parametric simulation model of the HRXV-15 was developed, model was used to define acceptable preliminary ranges of primary and secondary control schedules as functions of the flight parameters, to evaluate performance, flying qualities and structural loads, and to have a Boeing-Vertol pilot conduct a simulated flight test evaluation of the aircraft.

Hermetic compressor and block expansion valve in refrigeration performance

NASA Astrophysics Data System (ADS)

Santoso, Budi; Susilo, Didik Djoko; Tjahjana, D. D. D. P.

2016-03-01

Vehicle cabin in tropical countries requires the cooling during the day for comfort of passengers. Air conditioning machine is commonly driven by an internal combustion engine having a great power, which the conventional compressor is connected to crank shaft. The stage of research done is driving the hermetic compressor with an electric motor, and using block expansion valve. The HFC-134a was used as refrigerant working. The primary parameters observed during the experiment are pressure, temperature, and power consumption for different cooling capacities. The results show that the highest coefficient of performance (COP) and the electric power of system are 6.3 and 638 Watt, respectively.

Underground coal mine instrumentation and test

NASA Technical Reports Server (NTRS)

Burchill, R. F.; Waldron, W. D.

1976-01-01

The need to evaluate mechanical performance of mine tools and to obtain test performance data from candidate systems dictate that an engineering data recording system be built. Because of the wide range of test parameters which would be evaluated, a general purpose data gathering system was designed and assembled to permit maximum versatility. A primary objective of this program was to provide a specific operating evaluation of a longwall mining machine vibration response under normal operating conditions. A number of mines were visited and a candidate for test evaluation was selected, based upon management cooperation, machine suitability, and mine conditions. Actual mine testing took place in a West Virginia mine.

The Linear Programming to evaluate the performance of Oral Health in Primary Care.

PubMed

Colussi, Claudia Flemming; Calvo, Maria Cristina Marino; Freitas, Sergio Fernando Torres de

2013-01-01

To show the use of Linear Programming to evaluate the performance of Oral Health in Primary Care. This study used data from 19 municipalities of Santa Catarina city that participated of the state evaluation in 2009 and have more than 50,000 habitants. A total of 40 indicators were evaluated, calculated using the Microsoft Excel 2007, and converted to the interval [0, 1] in ascending order (one indicating the best situation and zero indicating the worst situation). Applying the Linear Programming technique municipalities were assessed and compared among them according to performance curve named "quality estimated frontier". Municipalities included in the frontier were classified as excellent. Indicators were gathered, and became synthetic indicators. The majority of municipalities not included in the quality frontier (values different of 1.0) had lower values than 0.5, indicating poor performance. The model applied to the municipalities of Santa Catarina city assessed municipal management and local priorities rather than the goals imposed by pre-defined parameters. In the final analysis three municipalities were included in the "perceived quality frontier". The Linear Programming technique allowed to identify gaps that must be addressed by city managers to enhance actions taken. It also enabled to observe each municipal performance and compare results among similar municipalities.

A disease-specific enteral nutrition formula improves nutritional status and functional performance in patients with head and neck and esophageal cancer undergoing chemoradiotherapy: results of a randomized, controlled, multicenter trial.

PubMed

Fietkau, Rainer; Lewitzki, Victor; Kuhnt, Thomas; Hölscher, Tobias; Hess, Clemens-F; Berger, Bernhard; Wiegel, Thomas; Rödel, Claus; Niewald, Marcus; Hermann, Robert M; Lubgan, Dorota

2013-09-15

In patients with head and neck and esophageal tumors, nutritional status may deteriorate during concurrent chemoradiotherapy (CRT). The aim of this study was to investigate the influence of enteral nutrition enriched with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on body composition and nutritional and functional status. In a controlled, randomized, prospective, double-blind, multicenter study, 111 patients with head and neck and esophageal cancer undergoing concurrent CRT received either an enteral standard nutrition (control group) or disease-specific enteral nutrition Supportan®-containing EPA+DHA (experimental group) via percutaneous endoscopic gastrostomy. The primary endpoint was the change of body cell mass (BCM) following CRT at weeks 7 and 14 compared with the baseline value. Secondary endpoints were additional parameters of body composition, anthropometric parameters, and nutritional and functional status. The primary endpoint of the study, improvement in BCM, reached borderline statistical significance. Following CRT, patients with experimental nutrition lost only 0.82 ± 0.64 kg of BCM compared with 2.82 ± 0.77 kg in the control group (P = .055). The objectively measured nutritional parameters, such as body weight and fat-free mass, showed a tendency toward improvement, but the differences were not significant. The subjective parameters, in particular the Kondrup score (P = .0165) and the subjective global assessment score (P = .0065) after follow-up improved significantly in the experimental group, compared with the control group. Both enteral regimens were safe and well tolerated. Enteral nutrition with EPA and DHA may be advantageous in patients with head and neck or esophageal cancer by improving parameters of nutritional and functional status during CRT. © 2013 American Cancer Society.

Novel Estimation of Pilot Performance Characteristics

NASA Technical Reports Server (NTRS)

Bachelder, Edward N.; Aponso, Bimal

2017-01-01

Two mechanisms internal to the pilot that affect performance during a tracking task are: 1) Pilot equalization (i.e. lead/lag); and 2) Pilot gain (i.e. sensitivity to the error signal). For some applications McRuer's Crossover Model can be used to anticipate what equalization will be employed to control a vehicle's dynamics. McRuer also established approximate time delays associated with different types of equalization - the more cognitive processing that is required due to equalization difficulty, the larger the time delay. However, the Crossover Model does not predict what the pilot gain will be. A nonlinear pilot control technique, observed and coined by the authors as 'amplitude clipping', is shown to improve stability, performance, and reduce workload when employed with vehicle dynamics that require high lead compensation by the pilot. Combining linear and nonlinear methods a novel approach is used to measure the pilot control parameters when amplitude clipping is present, allowing precise measurement in real time of key pilot control parameters. Based on the results of an experiment which was designed to probe workload primary drivers, a method is developed that estimates pilot spare capacity from readily observable measures and is tested for generality using multi-axis flight data. This paper documents the initial steps to developing a novel, simple objective metric for assessing pilot workload and its variation over time across a wide variety of tasks. Additionally, it offers a tangible, easily implementable methodology for anticipating a pilot's operating parameters and workload, and an effective design tool. The model shows promise in being able to precisely predict the actual pilot settings and workload, and observed tolerance of pilot parameter variation over the course of operation. Finally, an approach is proposed for generating Cooper-Harper ratings based on the workload and parameter estimation methodology.

Significance of Portal Venous Velocity in Short-term Graft Function in Living Donor Liver Transplantation.

PubMed

Wakiyama, S; Takano, Y; Shiba, H; Gocho, T; Sakamoto, T; Ishida, Y; Yanaga, K

2017-06-01

Graft regeneration and functional recovery after reperfusion of transplanted graft are very important for successful living donor liver transplantation (LDLT). The aim of this study was to evaluate the significance of postoperative portal venous velocity (PVV) in short-term recovery of graft function in LDLT. From February 2007 through December 2015, we performed 17 primary LDLTs, which were included in the present study. The patients ranged in age from 12 to 65 years (mean: 50 years), and 11 were female patients. Postoperatively, Doppler ultrasonography was performed daily to measure PVV (cm/s), and liver function parameters were measured daily. The change in PVV (ΔPVV) was defined as follows: ΔPVV = PVV on postoperative day (POD) 1 - PVV on POD 7. Maximal value of serum aspartate aminotransferase (ASTmax) and maximal value of serum alanine transaminase (ALTmax) at 24 hours after graft reperfusion were used as parameters of reperfusion injury. Correlation analyses were performed as follows: (1) correlation of ΔPVV and PVV on POD 1 (PVV-POD 1) with the values such as ASTmax, ALTmax, other liver function parameters on POD 7 and graft regeneration rate; (2) correlation of ASTmax and ALTmax with other liver function parameters on POD 7. ΔPVV significantly correlated with the values of serum total bilirubin (P < .01), prothrombin time (P < .01), and platelet count (P < .05), and PVV-POD 1 significantly correlated with the values of serum total bilirubin (P < .05) and prothrombin time (P < .05). ΔPVV and PVV-POD 1 may be useful parameters of short-term functional recovery of the transplant liver in LDLT. Copyright © 2017 Elsevier Inc. All rights reserved.

Assessing Disparities of Dengue Virus Transmission Risk across the US-Mexican Border Using a Climate Driven Vector-Epidemiological Model

NASA Technical Reports Server (NTRS)

Morin, Cory; Monaghan, Andrew; Quattrochi, Dale; Crosson, William; Hayden, Mary; Ernst, Kacey

2015-01-01

Dengue fever is a mosquito-borne viral disease reemerging throughout much of the tropical Americas. Dengue virus transmission is explicitly influenced by climate and the environment through its primary vector, Aedes aegypti. Temperature regulates Ae. aegypti development, survival, and replication rates as well as the incubation period of the virus within the mosquito. Precipitation provides water for many of the preferred breeding habitats of the mosquito, including buckets, old tires, and other places water can collect. Although transmission regularly occurs along the border region in Mexico, dengue virus transmission in bordering Arizona has not occurred. Using NASA's TRMM (Tropical Rainfall Measuring Mission) satellite for precipitation input and Daymet for temperature and supplemental precipitation input, we modeled dengue transmission along a US-Mexico transect using a dynamic dengue transmission model that includes interacting vector ecology and epidemiological components. Model runs were performed for 5 cities in Sonora, Mexico and southern Arizona. Employing a Monte Carlo approach, we performed ensembles of several thousands of model simulations in order to resolve the model uncertainty arising from using different combinations of parameter values that are not well known. For cities with reported dengue case data, the top model simulations that best reproduced dengue case numbers were retained and their parameter values were extracted for comparison. These parameter values were used to run simulations in areas where dengue virus transmission does not occur or where dengue fever case data was unavailable. Additional model runs were performed to reveal how changes in climate or parameter values could alter transmission risk along the transect. The relative influence of climate variability and model parameters on dengue virus transmission is assessed to help public health workers prepare location specific infection prevention strategies.

Analysis of spastic gait in cervical myelopathy: Linking compression ratio to spatiotemporal and pedobarographic parameters.

PubMed

Nagai, Taro; Takahashi, Yasuhito; Endo, Kenji; Ikegami, Ryo; Ueno, Ryuichi; Yamamoto, Kengo

2018-01-01

Gait dysfunction associated with spasticity and hyperreflexia is a primary symptom in patients with compression of cervical spinal cord. The objective of this study was to link maximum compression ratio (CR) to spatiotemporal/pedobarographic parameters. Quantitative gait analysis was performed by using a pedobarograph in 75 elderly males with a wide range of cervical compression severity. CR values were characterized on T1-weighted magnetic resonance imaging (MRI). Statistical significances in gait analysis parameters (speed, cadence, stride length, step with, and toe-out angle) were evaluated among different CR groups by the non-parametric Kruskal-Wallis test followed by the Mann-Whitney U test using Bonferroni correction. The Spearman test was performed to verify correlations between CR and gait parameters. The Kruskal-Wallis test revealed significant decline in gait speed and stride length and significant increase in toe-out angle with progression of cervical compression myelopathy. The post-hoc Mann-Whitney U test showed significant differences in these parameters between the control group (0.45

Improving SWAT for simulating water and carbon fluxes of forest ecosystems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Qichun; Zhang, Xuesong

2016-11-01

As a widely used watershed model for assessing impacts of anthropogenic and natural disturbances on water quantity and quality, the Soil and Water Assessment Tool (SWAT) has not been extensively tested in simulating water and carbon fluxes of forest ecosystems. Here, we examine SWAT simulations of evapotranspiration (ET), net primary productivity (NPP), net ecosystem exchange (NEE), and plant biomass at ten AmeriFlux forest sites across the U.S. We identify unrealistic radiation use efficiency (Bio_E), large leaf to biomass fraction (Bio_LEAF), and missing phosphorus supply from parent material weathering as the primary causes for the inadequate performance of the default SWATmore » model in simulating forest dynamics. By further revising the relevant parameters and processes, SWAT’s performance is substantially improved. Based on the comparison between the improved SWAT simulations and flux tower observations, we discuss future research directions for further enhancing model parameterization and representation of water and carbon cycling for forests.« less

Galvanostatic Intermittent Titration and Performance Based Analysis of LiNi 0.5 Co 0.2 Mn 0.3 O 2 Cathode

DOE Office of Scientific and Technical Information (OSTI.GOV)

Verma, Ankit; Smith, Kandler; Santhanagopalan, Shriram

Galvanostatic intermittent titration technique (GITT) - a popular method for characterizing kinetic and transport properties of battery electrodes - is predicated on the proper evaluation of electrode active area. LiNi 0.5044Co 0.1986Mn 0.2970O 2 (NCM523) material exhibits a complex morphology in which sub-micron primary particles aggregate to form secondary particle agglomerates. Our work proposes a new active area formulation for primary/secondary particle agglomerate materials to better mimic the morphology of NCM532 electrodes. Furthermore, this formulation is then coupled with macro-homogeneous models to simulate GITT and half-cell performance of NCM523 electrodes. Subsequently, the model results are compared against the experimental resultsmore » to refine the area formulation. A single parameter, the surface roughness factor, is proposed to mimic the change in interfacial area, diffusivity and exchange current density simultaneously and detailed modeling results are presented to provide valuable insights into the efficacy of the formulation.« less

Galvanostatic Intermittent Titration and Performance Based Analysis of LiNi 0.5Co 0.2 Mn 0.3O 2Cathode

DOE Office of Scientific and Technical Information (OSTI.GOV)

Verma, Ankit; Smith, Kandler; Santhanagopalan, Shriram

Galvanostatic intermittent titration technique (GITT) – a popular method for characterizing kinetic and transport properties of battery electrodes – is predicated on the proper evaluation of electrode active area. LiNi0.5044Co0.1986Mn0.2970O2 (NCM523) material exhibits a complex morphology in which sub-micron primary particles aggregate to form secondary particle agglomerates. This work proposes a new active area formulation for primary/secondary particle agglomerate materials to better mimic the morphology of NCM532 electrodes. This formulation is then coupled with macro-homogeneous models to simulate GITT and half-cell performance of NCM523 electrodes. Subsequently, the model results are compared against the experimental results to refine the area formulation.more » A single parameter, the surface roughness factor, is proposed to mimic the change in interfacial area, diffusivity and exchange current density simultaneously and detailed modeling results are presented to provide valuable insights into the efficacy of the formulation.« less

Galvanostatic Intermittent Titration and Performance Based Analysis of LiNi 0.5 Co 0.2 Mn 0.3 O 2 Cathode

DOE PAGES

Verma, Ankit; Smith, Kandler; Santhanagopalan, Shriram; ...

2017-11-03

Galvanostatic intermittent titration technique (GITT) - a popular method for characterizing kinetic and transport properties of battery electrodes - is predicated on the proper evaluation of electrode active area. LiNi 0.5044Co 0.1986Mn 0.2970O 2 (NCM523) material exhibits a complex morphology in which sub-micron primary particles aggregate to form secondary particle agglomerates. Our work proposes a new active area formulation for primary/secondary particle agglomerate materials to better mimic the morphology of NCM532 electrodes. Furthermore, this formulation is then coupled with macro-homogeneous models to simulate GITT and half-cell performance of NCM523 electrodes. Subsequently, the model results are compared against the experimental resultsmore » to refine the area formulation. A single parameter, the surface roughness factor, is proposed to mimic the change in interfacial area, diffusivity and exchange current density simultaneously and detailed modeling results are presented to provide valuable insights into the efficacy of the formulation.« less

Analytical performance, agreement and user-friendliness of six point-of-care testing urine analysers for urinary tract infection in general practice

PubMed Central

Schot, Marjolein J C; van Delft, Sanne; Kooijman-Buiting, Antoinette M J; de Wit, Niek J; Hopstaken, Rogier M

2015-01-01

Objective Various point-of-care testing (POCT) urine analysers are commercially available for routine urine analysis in general practice. The present study compares analytical performance, agreement and user-friendliness of six different POCT urine analysers for diagnosing urinary tract infection in general practice. Setting All testing procedures were performed at a diagnostic centre for primary care in the Netherlands. Urine samples were collected at four general practices. Primary and secondary outcome measures Analytical performance and agreement of the POCT analysers regarding nitrite, leucocytes and erythrocytes, with the laboratory reference standard, was the primary outcome measure, and analysed by calculating sensitivity, specificity, positive and negative predictive value, and Cohen's κ coefficient for agreement. Secondary outcome measures were the user-friendliness of the POCT analysers, in addition to other characteristics of the analysers. Results The following six POCT analysers were evaluated: Uryxxon Relax (Macherey Nagel), Urisys 1100 (Roche), Clinitek Status (Siemens), Aution 11 (Menarini), Aution Micro (Menarini) and Urilyzer (Analyticon). Analytical performance was good for all analysers. Compared with laboratory reference standards, overall agreement was good, but differed per parameter and per analyser. Concerning the nitrite test, the most important test for clinical practice, all but one showed perfect agreement with the laboratory standard. For leucocytes and erythrocytes specificity was high, but sensitivity was considerably lower. Agreement for leucocytes varied between good to very good, and for the erythrocyte test between fair and good. First-time users indicated that the analysers were easy to use. They expected higher productivity and accuracy when using these analysers in daily practice. Conclusions The overall performance and user-friendliness of all six commercially available POCT urine analysers was sufficient to justify routine use in suspected urinary tract infections in general practice. PMID:25986635

Design of a nonlinear torsional vibration absorber

NASA Astrophysics Data System (ADS)

Tahir, Ammaar Bin

Tuned mass dampers (TMD) utilizing linear spring mechanisms to mitigate destructive vibrations are commonly used in practice. A TMD is usually tuned for a specific resonant frequency or an operating frequency of a system. Recently, nonlinear vibration absorbers attracted attention of researchers due to some potential advantages they possess over the TMDs. The nonlinear vibration absorber, or the nonlinear energy sink (NES), has an advantage of being effective over a broad range of excitation frequencies, which makes it more suitable for systems with several resonant frequencies, or for a system with varying excitation frequency. Vibration dissipation mechanism in an NES is passive and ensures that there is no energy backflow to the primary system. In this study, an experimental setup of a rotational system has been designed for validation of the concept of nonlinear torsional vibration absorber with geometrically induced cubic stiffness nonlinearity. Dimensions of the primary system have been optimized so as to get the first natural frequency of the system to be fairly low. This was done in order to excite the dynamic system for torsional vibration response by the available motor. Experiments have been performed to obtain the modal parameters of the system. Based on the obtained modal parameters, the design optimization of the nonlinear torsional vibration absorber was carried out using an equivalent 2-DOF modal model. The optimality criterion was chosen to be maximization of energy dissipation in the nonlinear absorber attached to the equivalent 2-DOF system. The optimized design parameters of the nonlinear absorber were tested on the original 5-DOF system numerically. A comparison was made between the performance of linear and nonlinear absorbers using the numerical models. The comparison showed the superiority of the nonlinear absorber over its linear counterpart for the given set of primary system parameters as the vibration energy dissipation in the former is larger than that in the latter. A nonlinear absorber design has been proposed comprising of thin beams as elastic elements. The geometric configuration of the proposed design has been shown to provide cubic stiffness nonlinearity in torsion. The values of design variables, namely the strength of nonlinearity alpha and torsional stiffness kalpha, were obtained by optimizing dimensions and material properties of the beams for a maximum vibration energy dissipation in the nonlinear absorber. A parametric study has also been conducted to analyze the effect of the magnitude of excitation provided to the system on the performance of a nonlinear absorber. It has been shown that the nonlinear absorber turns out to be more effective in terms of energy dissipation as compared to a linear absorber with an increase in the excitation level applied to the system.

Bupropion for the treatment of apathy in Huntington’s disease: A multicenter, randomised, double-blind, placebo-controlled, prospective crossover trial

PubMed Central

Gelderblom, Harald; Wüstenberg, Torsten; McLean, Tim; Mütze, Lisanne; Fischer, Wilhelm; Saft, Carsten; Hoffmann, Rainer; Süssmuth, Sigurd; Schlattmann, Peter; van Duijn, Erik; Landwehrmeyer, Bernhard; Priller, Josef

2017-01-01

Objective To evaluate the efficacy and safety of bupropion in the treatment of apathy in Huntington’s disease (HD). Methods In this phase 2b multicentre, double-blind, placebo-controlled crossover trial, individuals with HD and clinical signs of apathy according to the Structured Clinical Interview for Apathy—Dementia (SCIA-D), but not depression (n = 40) were randomized to receive either bupropion 150/300mg or placebo daily for 10 weeks. The primary outcome parameter was a significant change of the Apathy Evaluation Scale (AES) score after ten weeks of treatment as judged by an informant (AES-I) living in close proximity with the study participant. The secondary outcome parameters included changes of 1. AES scores determined by the patient (AES-S) or the clinical investigator (AES-C), 2. psychiatric symptoms (NPI, HADS-SIS, UHDRS-Behavior), 3. cognitive performance (SDMT, Stroop, VFT, MMSE), 4. motor symptoms (UHDRS-Motor), 5. activities of daily function (TFC, UHDRS-Function), and 6. caregiver distress (NPI-D). In addition, we investigated the effect of bupropion on brain structure as well as brain responses and functional connectivity during reward processing in a gambling task using magnetic resonance imaging (MRI). Results At baseline, there were no significant treatment group differences in the clinical primary and secondary outcome parameters. At endpoint, there was no statistically significant difference between treatment groups for all clinical primary and secondary outcome variables. Study participation, irrespective of the intervention, lessened symptoms of apathy according to the informant and the clinical investigator. Conclusion Bupropion does not alleviate apathy in HD. However, study participation/placebo effects were observed, which document the need for carefully controlled trials when investigating therapeutic interventions for the neuropsychiatric symptoms of HD. Trial registration ClinicalTrials.gov 01914965 PMID:28323838

The effects of strawberry tree water leaf extract, arbutin and hydroquinone on haematological parameters and levels of primary DNA damage in white blood cells of rats.

PubMed

Jurica, Karlo; Brčić Karačonji, Irena; Kopjar, Nevenka; Shek-Vugrovečki, Ana; Cikač, Tihana; Benković, Vesna

2018-04-06

Strawberry tree (Arbutus unedo L., Ericaceae) leaves represent a potent source of biologically active compounds and have been used for a long to relieve symptoms of various health impairments and diseases. Two major compounds related to their beneficial activities in animals and humans are arbutin and hydroquinone. To establish potential benefit/risk ratio associated with daily oral administration of strawberry tree water leaf extract, arbutin and hydroquinone in doses expected to be non-toxic. We performed a 14-day and a 28-day study on male and female Lewis rats and evaluated main haematological parameters and the effects of treatments on the levels of primary DNA damage in white blood cells (WBC) using the alkaline comet assay. Our findings suggest no significant changes in the haematological parameters following prolonged exposure to strawberry tree water leaf extract, arbutin, and hydroquinone. However, hydroquinone causes increased, and extract as well as arbutin decreased WBC count in male rats compared to control after 14 days of treatment. DNA damage measured in WBC of rats treated with all compounds was below 10% of the DNA in the comet tail, which indicates low genotoxicity. The genotoxic potential of strawberry water leaf extract was within acceptable limits and reflected effects of a complex chemical composition upon DNA. We also observed slight gender- and exposure time- related differences in primary DNA damage in the leucocytes of control and treated rats. Future studies should investigate which doses of strawberry tree water leaf extract would be most promising for the potential use as a substitute for bearberry leaves for treatment of urinary infection. Copyright © 2017 Elsevier B.V. All rights reserved.

Computational material design for Q&P steels with plastic instability theory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cheng, G.; Choi, K. S.; Hu, X. H.

In this paper, the deformation limits of Quenching and Partitioning (Q&P) steels are examined with the plastic instability theory. For this purpose, the constituent phase properties of various Q&P steels were first experimentally obtained, and used to estimate the overall tensile stress-strain curves based on the simple rule of mixture (ROM) with the iso-strain and iso-stress assumptions. Plastic instability theory was then applied to the obtained overall stress-strain curves in order to estimate the deformation limits of the Q&P steels. A parametric study was also performed to examine the effects of various material parameters on the deformation limits of Q&Pmore » steels. Computational material design was subsequently carried out based on the information obtained from the parametric study. The results show that the plastic instability theory with iso-stress-based stress-strain curve may be used to provide the lower bound estimate of the uniform elongation (UE) for the various Q&P steels considered. The results also indicate that higher austenite stability/volume fractions, less strength difference between the primary phases, higher hardening exponents of the constituent phases are generally beneficial for the performance improvement of Q&P steels, and that various material parameters may be concurrently adjusted in a cohesive way in order to improve the performance of Q&P steel. The information from this study may be used to devise new heat treatment parameters and alloying elements to produce Q&P steels with the improved performance.« less

Event reweighting with the NuWro neutrino interaction generator

NASA Astrophysics Data System (ADS)

Pickering, Luke; Stowell, Patrick; Sobczyk, Jan

2017-09-01

Event reweighting has been implemented in the NuWro neutrino event generator for a number of free theory parameters in the interaction model. Event reweighting is a key analysis technique, used to efficiently study the effect of neutrino interaction model uncertainties. This opens up the possibility for NuWro to be used as a primary event generator by experimental analysis groups. A preliminary model tuning to ANL and BNL data of quasi-elastic and single pion production events was performed to validate the reweighting engine.

The 1992 activities of the International GPS Geodynamics Service (IGS).

NASA Astrophysics Data System (ADS)

Beutler, G.

The primary goal of the International GPS Geodynamics Service (IGS) is to give the scientific community high quality GPS orbits (and related information like earth orientation parameters) to perform regional or local GPS analyses without further orbit improvement. The declared goal of the three month 1992 IGS Test Campaign was the routine production of accurate GPS orbits using the observations of about 30 globally distributed IGS Core Sites. IGS Epoch Campaigns will be organized about every second year.

Method and system for assigning a confidence metric for automated determination of optic disc location

DOEpatents

Karnowski, Thomas P [Knoxville, TN; Tobin, Jr., Kenneth W.; Muthusamy Govindasamy, Vijaya Priya [Knoxville, TN; Chaum, Edward [Memphis, TN

2012-07-10

A method for assigning a confidence metric for automated determination of optic disc location that includes analyzing a retinal image and determining at least two sets of coordinates locating an optic disc in the retinal image. The sets of coordinates can be determined using first and second image analysis techniques that are different from one another. An accuracy parameter can be calculated and compared to a primary risk cut-off value. A high confidence level can be assigned to the retinal image if the accuracy parameter is less than the primary risk cut-off value and a low confidence level can be assigned to the retinal image if the accuracy parameter is greater than the primary risk cut-off value. The primary risk cut-off value being selected to represent an acceptable risk of misdiagnosis of a disease having retinal manifestations by the automated technique.

Metastable ripple phase of fully hydrated dipalmitoylphosphatidylcholine as studied by small angle x-ray scattering

PubMed Central

Yao, Haruhiko; Matuoka, Sinzi; Tenchov, Boris; Hatta, Ichiro

1991-01-01

Fully hydrated dipalmitoylphosphatidylcholine (DPPC) undergoes liquid crystalline to metastable Pβ, phase transition in cooling. A small angle x-ray scattering study has been performed for obtaining further evidence about the structure of this phase. From a high-resolution observation of x-ray diffraction profiles, a distinct multipeak pattern has become obvious. Among them the (01) reflection in the secondary ripple structure is identified clearly. There are peaks assigned straightforwardly to (10) and (20) reflections in the primary ripple structure and peaks assigned to (10) and (20) reflections in the secondary ripple structure. Therefore the multipeak pattern is due to superposition of the reflections cause by the primary and secondary ripple structures. The lattice parameters are estimated as follows: for the primary ripple structure a = 7.09 nm, b = 13.64 nm, and γ = 95°, and for the secondary ripple structure a = 8.2 nm, b = 26.6 nm, and γ = 90°. The lattice parameters thus obtained for the secondary ripple structure are not conclusive, however. The hydrocarbon chains in the primary ripple structure have been reported as being tilted against the bilayer plane and, on the other hand, the hydrocarbon chains in the secondary ripple structure are likely to be perpendicular to the bilayer plane. This fact seems to be related to a sequential mechanism of phase transitions. On heating from the Lβ, phase where the hydrocarbon chains are tilted the primary ripple structure having tilted hydrocarbon chains takes place and on cooling from the Lα phase where the hydrocarbon chains are not tilted the secondary ripple structure with untilted chains tends to be stabilized. It appears that the truly metastable ripple phase is expressed by the second ripple structure although in the course of the actual cooling transition both the secondary and primary ripple structures form and coexist. PMID:19431787

Cytoprotective Effect of Peptide Sedatin, an Agonist of μ/δ-Opioid Receptors, on Primary Culture of Pulmonary Fibroblasts of Albino Rats under Conditions of Oxidative Stress.

PubMed

Sazonova, E N; Samarina, E Yu; Lebed'ko, O A; Maltseva, I M; Timoshin, S S

2016-05-01

We studied the effects of a synthetic analogue of dermorphin peptide sedatin on DNA synthesis, nucleolar apparatus, and parameters of free radical oxidation in the primary culture of pulmonary fibroblasts under conditions of oxidative stress. Oxidative stress significantly enhanced production of superoxide anion radical in the culture, sufficiently inhibited DNA synthesis in fibroblasts, and reduced the size of cell nuclei and parameters of the nucleolar apparatus. Sedatin prevented accumulation of free radical oxidation products and changes in karyometry parameters induced by oxidative stress. The peptide completely eliminated changes in the parameters of fibroblast nucleolar apparatus and abolished the inhibitory effect of oxidative stress on the number of DNA-synthesizing cells. Pretreatment with non-selective opioid receptor antagonist naloxone hydrochloride partially abolished the effects of sedatin in the primary culture of pulmonary fibroblasts.

Childhood obesity: knowledge, attitudes, and practices of European pediatric care providers.

PubMed

Mazur, Artur; Matusik, Pawel; Revert, Krista; Nyankovskyy, Sergey; Socha, Piotr; Binkowska-Bury, Monika; Grzegorczyk, Joanna; Caroli, Margherita; Hassink, Sandra; Telega, Grzegorz; Malecka-Tendera, Ewa

2013-07-01

To determine and compare attitudes, skills, and practices in childhood obesity management in 4 European countries with different obesity prevalence, health care systems, and economic situations. A cross-sectional survey was distributed to primary health care providers from France, Italy, Poland, and Ukraine. The questionnaire was returned by 1119 participants with a response rate of 32.4%. The study revealed that most of the primary health care providers were convinced of their critical role in obesity management but did not feel sufficiently competent to perform effectively. The adherence to recommended practices such as routine weight and height measurements, BMI calculation, and plotting growth parameters on recommended growth charts was poor. Most primary health care providers recognized the need for continuing professional education in obesity management, stressing the importance of appropriate dietary counseling. The study underlines insufficient implementation of national guidelines for management of obesity regardless of the country and its health system. It also makes clear that the critical problem is not elaboration of guidelines but rather creating support systems for implementation of the medical standards among the primary care practitioners.

Galactic cosmic-ray model in the light of AMS-02 nuclei data

NASA Astrophysics Data System (ADS)

Niu, Jia-Shu; Li, Tianjun

2018-01-01

Cosmic ray (CR) physics has entered a precision-driven era. With the latest AMS-02 nuclei data (boron-to-carbon ratio, proton flux, helium flux, and antiproton-to-proton ratio), we perform a global fitting and constrain the primary source and propagation parameters of cosmic rays in the Milky Way by considering 3 schemes with different data sets (with and without p ¯ /p data) and different propagation models (diffusion-reacceleration and diffusion-reacceleration-convection models). We find that the data set with p ¯/p data can remove the degeneracy between the propagation parameters effectively and it favors the model with a very small value of convection (or disfavors the model with convection). The separated injection spectrum parameters are used for proton and other nucleus species, which reveal the different breaks and slopes among them. Moreover, the helium abundance, antiproton production cross sections, and solar modulation are parametrized in our global fitting. Benefited from the self-consistence of the new data set, the fitting results show a little bias, and thus the disadvantages and limitations of the existed propagation models appear. Comparing to the best fit results for the local interstellar spectra (ϕ =0 ) with the VOYAGER-1 data, we find that the primary sources or propagation mechanisms should be different between proton and helium (or other heavier nucleus species). Thus, how to explain these results properly is an interesting and challenging question.

Adaptive statistical iterative reconstruction improves image quality without affecting perfusion CT quantitation in primary colorectal cancer.

PubMed

Prezzi, D; Goh, V; Virdi, S; Mallett, S; Grierson, C; Breen, D J

2017-01-01

To determine the effect of Adaptive Statistical Iterative Reconstruction (ASIR) on perfusion CT (pCT) parameter quantitation and image quality in primary colorectal cancer. Prospective observational study. Following institutional review board approval and informed consent, 32 patients with colorectal adenocarcinoma underwent pCT (100 kV, 150 mA, 120 s acquisition, axial mode). Tumour regional blood flow (BF), blood volume (BV), mean transit time (MTT) and permeability surface area product (PS) were determined using identical regions-of-interests for ASIR percentages of 0%, 20%, 40%, 60%, 80% and 100%. Image noise, contrast-to-noise ratio (CNR) and pCT parameters were assessed across ASIR percentages. Coefficients of variation (CV), repeated measures analysis of variance (rANOVA) and Spearman' rank order correlation were performed with statistical significance at 5%. With increasing ASIR percentages, image noise decreased by 33% while CNR increased by 61%; peak tumour CNR was greater than 1.5 with 60% ASIR and above. Mean BF, BV, MTT and PS differed by less than 1.8%, 2.9%, 2.5% and 2.6% across ASIR percentages. CV were 4.9%, 4.2%, 3.3% and 7.9%; rANOVA P values: 0.85, 0.62, 0.02 and 0.81 respectively. ASIR improves image noise and CNR without altering pCT parameters substantially.

Mars Pathfinder Atmospheric Entry Navigation Operations

NASA Technical Reports Server (NTRS)

Braun, R. D.; Spencer, D. A.; Kallemeyn, P. H.; Vaughan, R. M.

1997-01-01

On July 4, 1997, after traveling close to 500 million km, the Pathfinder spacecraft successfully completed entry, descent, and landing, coming to rest on the surface of Mars just 27 km from its target point. In the present paper, the atmospheric entry and approach navigation activities required in support of this mission are discussed. In particular, the flight software parameter update and landing site prediction analyses performed by the Pathfinder operations navigation team are described. A suite of simulation tools developed during Pathfinder's design cycle, but extendible to Pathfinder operations, are also presented. Data regarding the accuracy of the primary parachute deployment algorithm is extracted from the Pathfinder flight data, demonstrating that this algorithm performed as predicted. The increased probability of mission success through the software parameter update process is discussed. This paper also demonstrates the importance of modeling atmospheric flight uncertainties in the estimation of an accurate landing site. With these atmospheric effects included, the final landed ellipse prediction differs from the post-flight determined landing site by less then 0.5 km in downtrack.

NASA Graduate Student Researchers Program (GSRP)

NASA Technical Reports Server (NTRS)

Freeman, Frederick G.

1998-01-01

The primary area of research that Dr. Prinzel conducted was concerned with the effects of automation on the ability to perform various tasks which simulated those performed in an airplane cockpit. While automation is generally considered to be a positive addition to the cockpit, it also has some negative effects. The primary negative effect is related to the decrease in the number of tasks the pilot needs to perform. Having less to do can actually result in a decreased ability to be aware of and react to ongoing events, some of which may be critical to flight operations. The research was concerned with the ability of adaptive automation using psychophysiological measures, specifically brain waves (i.e. EEG), to control the degree to which tasks are automated as a function of the subject's level of alertness. Dr. Prinzel conducted and participated in the running of a number of experiments that examined adaptive automation in conjunction with the MultiAttribute Task Battery. Since there has been very little research conducted in this area, experiments needed to be conducted which established basic parameters for future research. The experiments that Dr. Prinzel was involved with examined the optimum number and location of electrode sites for recording EEG, the types of tasks which could readily be automated, the number of tasks which could be controlled by the adaptive automation system, and various EEG recording parameters which affect system functioning. A secondary area in which Dr. Prinzel conducted research concerned performance on vigiliance tasks. This research, while not initially directly related to adaptive automation, does have implication for such systems. Vigilance requires long term monitoring which often leads to the kind of negative effects seen when automation is introduced into a work environment. A third area of research in which Dr. Prinzel conducted research was concerned with gender differences in cognitive functioning and how that related to strategies for performing various tasks.

Time-resolved characterization of primary particle emissions and secondary particle formation from a modern gasoline passenger car

NASA Astrophysics Data System (ADS)

Karjalainen, Panu; Timonen, Hilkka; Saukko, Erkka; Kuuluvainen, Heino; Saarikoski, Sanna; Aakko-Saksa, Päivi; Murtonen, Timo; Bloss, Matthew; Dal Maso, Miikka; Simonen, Pauli; Ahlberg, Erik; Svenningsson, Birgitta; Brune, William Henry; Hillamo, Risto; Keskinen, Jorma; Rönkkö, Topi

2016-07-01

Changes in vehicle emission reduction technologies significantly affect traffic-related emissions in urban areas. In many densely populated areas the amount of traffic is increasing, keeping the emission level high or even increasing. To understand the health effects of traffic-related emissions, both primary (direct) particulate emission and secondary particle formation (from gaseous precursors in the exhaust emissions) need to be characterized. In this study, we used a comprehensive set of measurements to characterize both primary and secondary particulate emissions of a Euro 5 level gasoline passenger car. Our aerosol particle study covers the whole process chain in emission formation, from the tailpipe to the atmosphere, and also takes into account differences in driving patterns. We observed that, in mass terms, the amount of secondary particles was 13 times higher than the amount of primary particles. The formation, composition, number and mass of secondary particles was significantly affected by driving patterns and engine conditions. The highest gaseous and particulate emissions were observed at the beginning of the test cycle when the performance of the engine and the catalyst was below optimal. The key parameter for secondary particle formation was the amount of gaseous hydrocarbons in primary emissions; however, also the primary particle population had an influence.

Fuzzy Mixed Assembly Line Sequencing and Scheduling Optimization Model Using Multiobjective Dynamic Fuzzy GA

PubMed Central

Tahriri, Farzad; Dawal, Siti Zawiah Md; Taha, Zahari

2014-01-01

A new multiobjective dynamic fuzzy genetic algorithm is applied to solve a fuzzy mixed-model assembly line sequencing problem in which the primary goals are to minimize the total make-span and minimize the setup number simultaneously. Trapezoidal fuzzy numbers are implemented for variables such as operation and travelling time in order to generate results with higher accuracy and representative of real-case data. An improved genetic algorithm called fuzzy adaptive genetic algorithm (FAGA) is proposed in order to solve this optimization model. In establishing the FAGA, five dynamic fuzzy parameter controllers are devised in which fuzzy expert experience controller (FEEC) is integrated with automatic learning dynamic fuzzy controller (ALDFC) technique. The enhanced algorithm dynamically adjusts the population size, number of generations, tournament candidate, crossover rate, and mutation rate compared with using fixed control parameters. The main idea is to improve the performance and effectiveness of existing GAs by dynamic adjustment and control of the five parameters. Verification and validation of the dynamic fuzzy GA are carried out by developing test-beds and testing using a multiobjective fuzzy mixed production assembly line sequencing optimization problem. The simulation results highlight that the performance and efficacy of the proposed novel optimization algorithm are more efficient than the performance of the standard genetic algorithm in mixed assembly line sequencing model. PMID:24982962

The surface roughness effect on the performance of supersonic ejectors

NASA Astrophysics Data System (ADS)

Brezgin, D. V.; Aronson, K. E.; Mazzelli, F.; Milazzo, A.

2017-07-01

The paper presents the numerical simulation results of the surface roughness influence on gas-dynamic processes inside flow parts of a supersonic ejector. These simulations are performed using two commercial CFD solvers (Star- CCM+ and Fluent). The results are compared to each other and verified by a full-scale experiment in terms of global flow parameters (the entrainment ratio: the ratio between secondary to primary mass flow rate - ER hereafter) and local flow parameters distribution (the static pressure distribution along the mixing chamber and diffuser walls). A detailed comparative study of the employed methods and approaches in both CFD packages is carried out in order to estimate the roughness effect on the logarithmic law velocity distribution inside the boundary layer. Influence of the surface roughness is compared with the influence of the backpressure (static pressure at the ejector outlet). It has been found out that increasing either the ejector backpressure or the surface roughness height, the shock position displaces upstream. Moreover, the numerical simulation results of an ejector with rough walls in the both CFD solvers are well quantitatively agreed with each other in terms of the mean ER and well qualitatively agree in terms of the local flow parameters distribution. It is found out that in the case of exceeding the "critical roughness height" for the given boundary conditions and ejector's geometry, the ejector switches to the "off-design" mode and its performance decreases considerably.

Effect of chronic nonmalignant pain on highway driving performance.

PubMed

Veldhuijzen, D S; van Wijck, A J M; Wille, F; Verster, J C; Kenemans, J L; Kalkman, C J; Olivier, B; Volkerts, E R

2006-05-01

Most pain patients are treated in an outpatient setting and are engaged in daily activities including driving. Since several studies showed that cognitive functioning may be impaired in chronic nonmalignant pain, the question arises whether or not chronic nonmalignant pain affects driving performance. Therefore, the objective of the present study was to determine the effects of chronic nonmalignant pain on actual highway driving performance during normal traffic. Fourteen patients with chronic nonmalignant pain and 14 healthy controls, matched on age, educational level, and driving experience, participated in the study. Participants performed a standardized on-the-road driving test during normal traffic, on a primary highway. The primary parameter of the driving test is the Standard Deviation of Lateral Position (SDLP). In addition, driving-related skills (tracking, divided attention, and memory) were examined in the laboratory. Subjective assessments, such as pain intensity, and subjective driving quality, were rated on visual analogue scales. The results demonstrated that a subset of chronic nonmalignant pain patients had SDLPs that were higher than the matched healthy controls, indicating worse highway driving performance. Overall, there was a statistically significant difference in highway driving performance between the groups. Further, chronic nonmalignant pain patients rated their subjective driving quality to be normal, although their ratings were significantly lower than those of the healthy controls. No significant effects were found on the laboratory tests.

Using evolutionary algorithms for fitting high-dimensional models to neuronal data.

PubMed

Svensson, Carl-Magnus; Coombes, Stephen; Peirce, Jonathan Westley

2012-04-01

In the study of neurosciences, and of complex biological systems in general, there is frequently a need to fit mathematical models with large numbers of parameters to highly complex datasets. Here we consider algorithms of two different classes, gradient following (GF) methods and evolutionary algorithms (EA) and examine their performance in fitting a 9-parameter model of a filter-based visual neuron to real data recorded from a sample of 107 neurons in macaque primary visual cortex (V1). Although the GF method converged very rapidly on a solution, it was highly susceptible to the effects of local minima in the error surface and produced relatively poor fits unless the initial estimates of the parameters were already very good. Conversely, although the EA required many more iterations of evaluating the model neuron's response to a series of stimuli, it ultimately found better solutions in nearly all cases and its performance was independent of the starting parameters of the model. Thus, although the fitting process was lengthy in terms of processing time, the relative lack of human intervention in the evolutionary algorithm, and its ability ultimately to generate model fits that could be trusted as being close to optimal, made it far superior in this particular application than the gradient following methods. This is likely to be the case in many further complex systems, as are often found in neuroscience.

Hypoxia and flight performance of military instructor pilots in a flight simulator.

PubMed

Temme, Leonard A; Still, David L; Acromite, Michael T

2010-07-01

Military aircrew and other operational personnel frequently perform their duties at altitudes posing a significant hypoxia risk, often with limited access to supplemental oxygen. Despite the significant risk hypoxia poses, there are few studies relating it to primary flight performance, which is the purpose of the present study. Objective, quantitative measures of aircraft control were collected from 14 experienced, active duty instructor pilot volunteers as they breathed an air/nitrogen mix that provided an oxygen partial pressure equivalent to the atmosphere at 18,000 ft (5486.4 m) above mean sea level. The flight task required holding a constant airspeed, altitude, and heading at an airspeed significantly slower than the aircraft's minimum drag speed. The simulated aircraft's inherent instability at the target speed challenged the pilot to maintain constant control of the aircraft in order to minimize deviations from the assigned flight parameters. Each pilot's flight performance was evaluated by measuring all deviations from assigned target values. Hypoxia degraded the pilot's precision of altitude and airspeed control by 53%, a statistically significant decrease in flight performance. The effect on heading control effects was not statistically significant. There was no evidence of performance differences when breathing room air pre- and post-hypoxia. Moderate levels of hypoxia degraded the ability of military instructor pilots to perform a precision slow flight task. This is one of a small number of studies to quantify an effect of hypoxia on primary flight performance.

Off-resonance frequency operation for power transfer in a loosely coupled air core transformer

DOEpatents

Scudiere, Matthew B

2012-11-13

A power transmission system includes a loosely coupled air core transformer having a resonance frequency determined by a product of inductance and capacitance of a primary circuit including a primary coil. A secondary circuit is configured to have a substantially same product of inductance and capacitance. A back EMF generating device (e.g., a battery), which generates a back EMF with power transfer, is attached to the secondary circuit. Once the load power of the back EMF generating device exceeds a certain threshold level, which depends on the system parameters, the power transfer can be achieved at higher transfer efficiency if performed at an operating frequency less than the resonance frequency, which can be from 50% to 95% of the resonance frequency.

Land-surface parameter optimisation using data assimilation techniques: the adJULES system V1.0

NASA Astrophysics Data System (ADS)

Raoult, Nina M.; Jupp, Tim E.; Cox, Peter M.; Luke, Catherine M.

2016-08-01

Land-surface models (LSMs) are crucial components of the Earth system models (ESMs) that are used to make coupled climate-carbon cycle projections for the 21st century. The Joint UK Land Environment Simulator (JULES) is the land-surface model used in the climate and weather forecast models of the UK Met Office. JULES is also extensively used offline as a land-surface impacts tool, forced with climatologies into the future. In this study, JULES is automatically differentiated with respect to JULES parameters using commercial software from FastOpt, resulting in an analytical gradient, or adjoint, of the model. Using this adjoint, the adJULES parameter estimation system has been developed to search for locally optimum parameters by calibrating against observations. This paper describes adJULES in a data assimilation framework and demonstrates its ability to improve the model-data fit using eddy-covariance measurements of gross primary production (GPP) and latent heat (LE) fluxes. adJULES also has the ability to calibrate over multiple sites simultaneously. This feature is used to define new optimised parameter values for the five plant functional types (PFTs) in JULES. The optimised PFT-specific parameters improve the performance of JULES at over 85 % of the sites used in the study, at both the calibration and evaluation stages. The new improved parameters for JULES are presented along with the associated uncertainties for each parameter.

Effect of 6-month community-based exercise interventions on gait and functional fitness of an older population: a quasi-experimental study.

PubMed

Ramalho, Fátima; Santos-Rocha, Rita; Branco, Marco; Moniz-Pereira, Vera; André, Helô-Isa; Veloso, António P; Carnide, Filomena

2018-01-01

Gait ability in older adults has been associated with independent living, increased survival rates, fall prevention, and quality of life. There are inconsistent findings regarding the effects of exercise interventions in the maintenance of gait parameters. The aim of the study was to analyze the effects of a community-based periodized exercise intervention on the improvement of gait parameters and functional fitness in an older adult group compared with a non-periodized program. A quasi-experimental study with follow-up was performed in a periodized exercise group (N=15) and in a non-periodized exercise group (N=13). The primary outcomes were plantar pressure gait parameters, and the secondary outcomes were physical activity, aerobic endurance, lower limb strength, agility, and balance. These variables were recorded at baseline and after 6 months of intervention. Both programs were tailored to older adults' functional fitness level and proved to be effective in reducing the age-related decline regarding functional fitness and gait parameters. Gait parameters were sensitive to both the exercise interventions. These exercise protocols can be used by exercise professionals in prescribing community exercise programs, as well as by health professionals in promoting active aging.

Topology-optimization-based design method of flexures for mounting the primary mirror of a large-aperture space telescope.

PubMed

Hu, Rui; Liu, Shutian; Li, Quhao

2017-05-20

For the development of a large-aperture space telescope, one of the key techniques is the method for designing the flexures for mounting the primary mirror, as the flexures are the key components. In this paper, a topology-optimization-based method for designing flexures is presented. The structural performances of the mirror system under multiple load conditions, including static gravity and thermal loads, as well as the dynamic vibration, are considered. The mirror surface shape error caused by gravity and the thermal effect is treated as the objective function, and the first-order natural frequency of the mirror structural system is taken as the constraint. The pattern repetition constraint is added, which can ensure symmetrical material distribution. The topology optimization model for flexure design is established. The substructuring method is also used to condense the degrees of freedom (DOF) of all the nodes of the mirror system, except for the nodes that are linked to the mounting flexures, to reduce the computation effort during the optimization iteration process. A potential optimized configuration is achieved by solving the optimization model and post-processing. A detailed shape optimization is subsequently conducted to optimize its dimension parameters. Our optimization method deduces new mounting structures that significantly enhance the optical performance of the mirror system compared to the traditional methods, which only focus on the parameters of existing structures. Design results demonstrate the effectiveness of the proposed optimization method.

Effect of hydrogen addition on soot formation in an ethylene/air premixed flame

NASA Astrophysics Data System (ADS)

De Iuliis, S.; Maffi, S.; Migliorini, F.; Cignoli, F.; Zizak, G.

2012-03-01

The effect of hydrogen addition to fuel in soot formation and growth mechanisms is investigated in a rich ethylene/air premixed flame. To this purpose, three-angle scattering and extinction measurements are carried out in flames with different hydrogen contents. By applying the Rayleigh-Debye-Gans theory and the fractal-like description, soot concentration and morphology, with the evaluation of radius of gyration, volume-mean diameter and primary particle diameter are retrieved. To derive fractal parameters such as fractal dimension and fractal prefactor to be used for optical measurements, sampling technique and TEM analysis are performed. In addition, data concerning soot morphology obtained from TEM analysis are compared with the optical results. A good agreement in the value of the primary particle diameter between optical and ex-situ measurements is found. Significant effects of hydrogen addition are detected and presented in this work. In particular, hydrogen addition to fuel is responsible for a reduction in soot concentration, radius of gyration and primary particle diameter.

Outgassing of Out-of-Autoclave Composite Primary Structures for Small Satellites

NASA Astrophysics Data System (ADS)

Komus, Alastair

Out-of-autoclave vacuum-bagged-only (VBO) processing is capable of producing lower cost composite primary structures for small satellites than autoclave processing. However, the outgassing performance of VBO structures in a vacuum environment has not been examined. Panels were manufactured from CYCOM 5320-1 and TC275-1 carbon fiber/epoxy prepreg using VBO processing. The humidity level, pre-cure dwell time, and cure cycle parameters were varied during manufacturing. The degree of cure and glass transition temperature were shown to increase with increasing oven temperature. Processing humidity levels and the length of pre-cure dwell times had no discernable effect on the total mass loss (TML) and collected volatile condensable material (CVCM) that were outgassed under vacuum. Instead the TML was controlled by moisture saturation after manufacturing. Fourier transform infrared spectroscopy showed that epoxy oligomers were the primary CVCM. The study showed the VBO laminates had outgassing values that were comparable to the autoclave-cured laminates.

Monte Carlo-based assessment of the trade-off between spatial resolution, field-of-view and scattered radiation in the variable resolution X-ray CT scanner.

PubMed

Arabi, Hossein; Kamali Asl, Ali Reza; Ay, Mohammad Reza; Zaidi, Habib

2015-07-01

The purpose of this work is to evaluate the impact of optimization of magnification on performance parameters of the variable resolution X-ray (VRX) CT scanner. A realistic model based on an actual VRX CT scanner was implemented in the GATE Monte Carlo simulation platform. To evaluate the influence of system magnification, spatial resolution, field-of-view (FOV) and scatter-to-primary ratio of the scanner were estimated for both fixed and optimum object magnification at each detector rotation angle. Comparison and inference between these performance parameters were performed angle by angle to determine appropriate object position at each opening half angle. Optimization of magnification resulted in a trade-off between spatial resolution and FOV of the scanner at opening half angles of 90°-12°, where the spatial resolution increased up to 50% and the scatter-to-primary ratio decreased from 4.8% to 3.8% at a detector angle of about 90° for the same FOV and X-ray energy spectrum. The disadvantage of magnification optimization at these angles is the significant reduction of the FOV (up to 50%). Moreover, magnification optimization was definitely beneficial for opening half angles below 12° improving the spatial resolution from 7.5 cy/mm to 20 cy/mm. Meanwhile, the FOV increased by more than 50% at these angles. It can be concluded that optimization of magnification is essential for opening half angles below 12°. For opening half angles between 90° and 12°, the VRX CT scanner magnification should be set according to the desired spatial resolution and FOV. Copyright © 2015 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

The Grass Isn’t Always Greener: Perceptions of and Performance on Open-Note Exams

PubMed Central

Sato, Brian K.; He, Wenliang; Warschauer, Mark; Kadandale, Pavan

2015-01-01

Undergraduate biology education is often viewed as being focused on memorization rather than development of students’ critical-thinking abilities. We speculated that open-note testing would be an easily implemented change that would emphasize higher-order thinking. As open-note testing is not commonly used in the biological sciences and the literature on its effects in biology education is sparse, we performed a comprehensive analysis of this intervention on a primary literature–based exam across three large-enrollment laboratory courses. Although students believed open-note testing would impact exam scores, we found no effect on performance, either overall or on questions of nearly all Bloom’s levels. Open-note testing also produced no advantage when examined under a variety of parameters, including research experience, grade point average, course grade, prior exposure to primary literature–focused laboratory courses, or gender. Interestingly, we did observe small differences in open- and closed-note exam performance and perception for students who experienced open-note exams for an entire quarter. This implies that student preparation or in-test behavior can be altered by exposure to open-note testing conditions in a single course and that ­increased experience may be necessary to truly understand the impact of this intervention. PMID:25828402

An Ultra-low-power Medium Access Control Protocol for Body Sensor Network.

PubMed

Li, Huaming; Tan, Jindong

2005-01-01

In this paper, a medium access control (MAC) protocol designed for Body Sensor Network (BSN-MAC) is proposed. BSN-MAC is an adaptive, feedback-based and IEEE 802.15.4-compatible MAC protocol. Due to the traffic coupling and sensor diversity characteristics of BSNs, common MAC protocols can not satisfy the unique requirements of the biomedical sensors in BSN. BSN-MAC exploits the feedback information from the deployed sensors to form a closed-loop control of the MAC parameters. A control algorithm is proposed to enable the BSN coordinator to adjust parameters of the IEEE 802.15.4 superframe to achieve both energy efficiency and low latency on energy critical nodes. We evaluate the performance of BSN-MAC using energy efficiency as the primary metric.

Numerical Analysis of a Rotating Detonation Engine in the Relative Reference Frame

NASA Technical Reports Server (NTRS)

Paxson, Daniel E.

2014-01-01

A two-dimensional, computational fluid dynamic (CFD) simulation of a semi-idealized rotating detonation engine (RDE) is described. The simulation operates in the detonation frame of reference and utilizes a relatively coarse grid such that only the essential primary flow field structure is captured. This construction yields rapidly converging, steady solutions. Results from the simulation are compared to those from a more complex and refined code, and found to be in reasonable agreement. The performance impacts of several RDE design parameters are then examined. Finally, for a particular RDE configuration, it is found that direct performance comparison can be made with a straight-tube pulse detonation engine (PDE). Results show that they are essentially equivalent.

The influence of retraction agents on cytoskeleton reorganization and oxidative stress in primary human gingival fibroblasts (HGFs).

PubMed

Nowakowska, Danuta; Saczko, Jolanta; Bieżuńska-Kusiak, Katarzyna; Choromańska, Anna; Dubińska-Magiera, Magda; Ziętek, Marek; Kulbacka, Julita

2014-03-01

Contemporary gingival retraction chemicals are not without disagreeable side-effects; there appears to be no best gingival retraction agent. The aim of this research was to select the most biocompatible retraction agents based on examination of the parameters of oxidative stress in fibroblasts derived from human primary cell culture. In this in vitro study we evaluated parameters of oxidative stress after treatment with retraction agents. Visine, Afrin, Neosynephrin, Strazolin and Adrenaline were the commercial products studied as gingival retraction agents. Additionally we examined three experimental agents. We determined lipid peroxidation and protein damage and monitored changes in cellular cytoskeleton proteins. Proliferative and survival efficiency were also evaluated. Oxidative changes included by evaluated retraction agents were at the lowest level in the case of the experimental gels. Also cytoskeleton observations suggest that the experimental agents did not degrade the cellular structure of human gingival fibroblasts (HGFs). The current study was performed because of a need to project new nontoxic and save retraction agents for peridontological therapeutic usage. We suggest that the new investigational gels are most biocompatible with periodontal tissues and can be applied as new vasoconstrictor chemical retraction agents. Copyright © 2014 Elsevier Ltd. All rights reserved.

Phenomenological model of nuclear primary air showers

NASA Technical Reports Server (NTRS)

Tompkins, D. R., Jr.; Saterlie, S. F.

1976-01-01

The development of proton primary air showers is described in terms of a model based on a hadron core plus an electromagnetic cascade. The muon component is neglected. The model uses three parameters: a rate at which hadron core energy is converted into electromagnetic cascade energy and a two-parameter sea-level shower-age function. By assuming an interaction length for the primary nucleus, the model is extended to nuclear primaries. Both models are applied over the energy range from 10 to the 13th power to 10 to the 21st power eV. Both models describe the size and age structure (neglecting muons) from a depth of 342 to 2052 g/sq cm.

Effect of naringenin in Qianggu capsule on population pharmacokinetics in Chinese women with primary osteoporosis.

PubMed

Jiannong, Wang; Junjie, Jiang; Yanming, Xie; Xu, Wei; Jianpeng, Li; Jingli, Duan; Xin, Xiong

2015-04-01

To characterize naringenin (NAR) pop- ulation pharmacokinetics (PPK) in Chinese women with primary osteoporosis. Ninety-eight female patients with primary osteoporosis from the Jingshan, Beixinqiao, Jiaodaokou, Chaoyangmen, and Donghuamen communities in Beijing, China, aged 40 to 80 years, re- ceived oral Qianggu capsules (250 mg). Blood samples were collected before and at 0.5, 1, 2, 3, 4, 6, 8, 10, 12, and 24 h after administration. The concentration of NAR in the blood samples was measured using high performance liquid chromatography-tandem mass spectrometry. PPK analyses were performed with nonlinear mixed-effect modeling software (version 7.1.2, PsN3.2.12). The clearance (C1), central distribution volume (V), absorption rate constant (Ka1), peripheral distribution volume (VII), and inter-compartmental clearance (CLII) were set as parameters and estimated by the base model, covariate model, and final model. Kidney-Yang deficiency [Shenyangxu (SYAX)] and liver-kidney-Yin deficiency (Ganshenyinxu) are patterns of symptoms in Traditional Chinese Medicine that were set as covariates, along with age, height, blood urea nitrogen, serum creatinine, alanine transaminase, aspartate transaminase, and hyperlipidemia. Both stepwise forward and backward procedures were accomplished to build models. The final model was evaluated by internal and external validation, visual predictive check, bootstrap, and leverage analysis. A one compartment open model with first order degradation was the best fitted to the concentration-time profiles following oral administration of NAR. The mean of population parameters of the final model, C1, SYAX on C1, V, Ka1, CLII, and VII, were measured to be 37.6 L/h, 0.427 L, 123 L/h, 0.12/h, 0.3056, and 1.446, respectively. Inter-individual variability was estimated and SYAX was identified as a significant covariate. The population pharmacokinetic model described in this study could effectively characterize the pharmacokinetic profile of NAR following administration of a single dose of oral Qianggu capsules in Chinese women with primary osteoporosis. Among the tested covariates, only SYAX was a significant factor.

A proposed Primary Health Early Warning Score (PHEWS) with emphasis on early detection of sepsis in the elderly.

PubMed

Anderson, Ian

2016-03-01

There are several secondary care early warning scores which alert for severe illness including sepsis. None are specifically adjusted for primary care. A Primary Health Early Warning Score (PHEWS) is proposed which incorporates practical parameters from both secondary and primary care.

Short-term to seasonal variability in factors driving primary productivity in a shallow estuary: Implications for modeling production

NASA Astrophysics Data System (ADS)

Canion, Andy; MacIntyre, Hugh L.; Phipps, Scott

2013-10-01

The inputs of primary productivity models may be highly variable on short timescales (hourly to daily) in turbid estuaries, but modeling of productivity in these environments is often implemented with data collected over longer timescales. Daily, seasonal, and spatial variability in primary productivity model parameters: chlorophyll a concentration (Chla), the downwelling light attenuation coefficient (kd), and photosynthesis-irradiance response parameters (Pmchl, αChl) were characterized in Weeks Bay, a nitrogen-impacted shallow estuary in the northern Gulf of Mexico. Variability in primary productivity model parameters in response to environmental forcing, nutrients, and microalgal taxonomic marker pigments were analysed in monthly and short-term datasets. Microalgal biomass (as Chla) was strongly related to total phosphorus concentration on seasonal scales. Hourly data support wind-driven resuspension as a major source of short-term variability in Chla and light attenuation (kd). The empirical relationship between areal primary productivity and a combined variable of biomass and light attenuation showed that variability in the photosynthesis-irradiance response contributed little to the overall variability in primary productivity, and Chla alone could account for 53-86% of the variability in primary productivity. Efforts to model productivity in similar shallow systems with highly variable microalgal biomass may benefit the most by investing resources in improving spatial and temporal resolution of chlorophyll a measurements before increasing the complexity of models used in productivity modeling.

A statistical model for characterizing common air pollutants in air-conditioned offices

NASA Astrophysics Data System (ADS)

Wong, L. T.; Mui, K. W.; Hui, P. S.

Maintaining acceptable indoor air quality (IAQ) for a healthy environment is of primary concern, policymakers have developed different strategies to address the performance of it based on proper assessment methodologies and monitoring plans. It could be cost prohibitive to sample all toxic pollutants in a building. In search of a more manageable number of parameters for cost-effective IAQ assessment, this study investigated the probable correlations among the 12 indoor environmental parameters listed in the IAQ certification scheme of the Hong Kong Environment Protection Department (HKEPD) in 422 Hong Kong offices. These 12 parameters consists of nine indoor air pollutants: carbon dioxide (CO 2), carbon monoxide (CO), respirable suspended particulates (RSP), nitrogen dioxide (NO 2), ozone (O 3), formaldehyde (HCHO), total volatile organic compounds (TVOC), radon (Rn), airborne bacteria count (ABC); and three thermal comfort parameters: temperature ( T), relative humidity (RH) and air velocity ( V). The relative importance of the correlations derived, from largest to smallest loadings, was ABC, Rn, CO, RH, RSP, CO 2, TVOC, O 3, T, V, NO 2 and HCHO. Together with the mathematical expressions derived, an alternative sampling protocol for IAQ assessment with the three 'most representative and independent' parameters namely RSP, CO 2 and TVOC measured in an office environment was proposed. The model validity was verified with on site measurements from 43 other offices in Hong Kong. The measured CO 2, RSP and TVOC concentrations were used to predict the probable levels of the other nine parameters and good agreement was found between the predictions and measurements. This simplified protocol provides an easy tool for performing IAQ monitoring in workplaces and will be useful for determining appropriate mitigation measures to finally honor the certification scheme in a cost-effective way.

Nomogram for 30-day morbidity after primary cytoreductive surgery for advanced stage ovarian cancer.

PubMed

Nieuwenhuyzen-de Boer, G M; Gerestein, C G; Eijkemans, M J C; Burger, C W; Kooi, G S

2016-01-01

Extensive surgical procedures to achieve maximal cytoreduction in patients with advanced stage epithelial ovarian cancer (EOC) are inevitably associated with postoperative morbidity and mortality. This study aimed to identify preoperative predictors of 30-day morbidity after primary cytoreductive surgery for advanced stage EOC and to develop a nomogram for individual risk assessment. Patients in The Netherlands who underwent primary cytoreductive surgery for advanced stage EOC between January 2004 and December 2007. All peri- and postoperative complications within 30 days after surgery were registered and classified. To investigate predictors of 30-day morbidity, a Cox proportional hazard model with backward stepwise elimination was utilized. The identified predictors were entered into a nomogram. The main outcome was to identify parameters that predict operative risk. 293 patients entered the study protocol. Optimal cytoreduction was achieved in 136 (46%) patients. Thirty-day morbidity was seen in 99 (34%) patients. Morbidity could be predicted by age (p = 0.033; OR 1.024), preoperative hemoglobin (p = 0.194; OR 0.843), and WHO performance status (p = 0.015; OR 1.821) with a optimism-corrected c-statistic of 0.62. Determinants co-morbidity status, serum CA125 level, platelet count, and presence of ascites were comparable in both groups. Thirty-day morbidity after primary cytoreductive surgery for advanced stage EOC could be predicted by age, hemoglobin, and WHO performance status. The generated nomogram could be valuable for predicting operative risk in the individual patient.

The development of an adaptive upper-limb stroke rehabilitation robotic system

PubMed Central

2011-01-01

Background Stroke is the primary cause of adult disability. To support this large population in recovery, robotic technologies are being developed to assist in the delivery of rehabilitation. This paper presents an automated system for a rehabilitation robotic device that guides stroke patients through an upper-limb reaching task. The system uses a decision theoretic model (a partially observable Markov decision process, or POMDP) as its primary engine for decision making. The POMDP allows the system to automatically modify exercise parameters to account for the specific needs and abilities of different individuals, and to use these parameters to take appropriate decisions about stroke rehabilitation exercises. Methods The performance of the system was evaluated by comparing the decisions made by the system with those of a human therapist. A single patient participant was paired up with a therapist participant for the duration of the study, for a total of six sessions. Each session was an hour long and occurred three times a week for two weeks. During each session, three steps were followed: (A) after the system made a decision, the therapist either agreed or disagreed with the decision made; (B) the researcher had the device execute the decision made by the therapist; (C) the patient then performed the reaching exercise. These parts were repeated in the order of A-B-C until the end of the session. Qualitative and quantitative question were asked at the end of each session and at the completion of the study for both participants. Results Overall, the therapist agreed with the system decisions approximately 65% of the time. In general, the therapist thought the system decisions were believable and could envision this system being used in both a clinical and home setting. The patient was satisfied with the system and would use this system as his/her primary method of rehabilitation. Conclusions The data collected in this study can only be used to provide insight into the performance of the system since the sample size was limited. The next stage for this project is to test the system with a larger sample size to obtain significant results. PMID:21679457

The Rangeland Hydrology and Erosion Model: A Dynamic Approach for Predicting Soil Loss on Rangelands

NASA Astrophysics Data System (ADS)

Hernandez, Mariano; Nearing, Mark A.; Al-Hamdan, Osama Z.; Pierson, Frederick B.; Armendariz, Gerardo; Weltz, Mark A.; Spaeth, Kenneth E.; Williams, C. Jason; Nouwakpo, Sayjro K.; Goodrich, David C.; Unkrich, Carl L.; Nichols, Mary H.; Holifield Collins, Chandra D.

2017-11-01

In this study, we present the improved Rangeland Hydrology and Erosion Model (RHEM V2.3), a process-based erosion prediction tool specific for rangeland application. The article provides the mathematical formulation of the model and parameter estimation equations. Model performance is assessed against data collected from 23 runoff and sediment events in a shrub-dominated semiarid watershed in Arizona, USA. To evaluate the model, two sets of primary model parameters were determined using the RHEM V2.3 and RHEM V1.0 parameter estimation equations. Testing of the parameters indicated that RHEM V2.3 parameter estimation equations provided a 76% improvement over RHEM V1.0 parameter estimation equations. Second, the RHEM V2.3 model was calibrated to measurements from the watershed. The parameters estimated by the new equations were within the lowest and highest values of the calibrated parameter set. These results suggest that the new parameter estimation equations can be applied for this environment to predict sediment yield at the hillslope scale. Furthermore, we also applied the RHEM V2.3 to demonstrate the response of the model as a function of foliar cover and ground cover for 124 data points across Arizona and New Mexico. The dependence of average sediment yield on surface ground cover was moderately stronger than that on foliar cover. These results demonstrate that RHEM V2.3 predicts runoff volume, peak runoff, and sediment yield with sufficient accuracy for broad application to assess and manage rangeland systems.

Radiation characteristics and implosion dynamics of Z-pinch dynamic hohlraums performed on PTS facility

NASA Astrophysics Data System (ADS)

Huang, Xian Bin; Ren, Xiao Dong; Dan, Jia Kun; Wang, Kun Lun; Xu, Qiang; Zhou, Shao Tong; Zhang, Si Qun; Cai, Hong Chun; Li, Jing; Wei, Bing; Ji, Ce; Feng, Shu Ping; Wang, Meng; Xie, Wei Ping; Deng, Jian Jun

2017-09-01

The preliminary experimental results of Z-pinch dynamic hohlraums conducted on the Primary Test Stand (PTS) facility are presented herein. Six different types of dynamic hohlraums were used in order to study the influence of load parameters on radiation characteristics and implosion dynamics, including dynamic hohlraums driven by single and nested arrays with different array parameters and different foams. The PTS facility can deliver a current of 6-8 MA in the peak current and 60-70 ns in the 10%-90% rising time to dynamic hohlraum loads. A set of diagnostics monitor the implosion dynamics of plasmas, the evolution of shock waves in the foam and the axial/radial X-ray radiation, giving the key parameters characterizing the features of dynamic hohlraums, such as the trajectory and related velocity of shock waves, radiation temperature, and so on. The experimental results presented here put our future study on Z-pinch dynamic hohlraums on the PTS facility on a firm basis.

How do geometry-related parameters influence the clinical performance of orthodontic mini-implants? A systematic review and meta-analysis.

PubMed

Cunha, A C; da Veiga, A M A; Masterson, D; Mattos, C T; Nojima, L I; Nojima, M C G; Maia, L C

2017-12-01

The aim of this systematic review and meta-analysis was to investigate how parameters related to geometry influence the clinical performance of orthodontic mini-implants (MIs). Systematic searches were performed in electronic databases including MEDLINE, Scopus, Web of Science, Virtual Health Library, and Cochrane Library and reference lists up to March 2016. Eligibility criteria comprised clinical studies involving patients who received MIs for orthodontic anchorage, with data for categories of MI dimension, shape, and thread design and insertion site, and evaluated by assessment of primary and secondary stability. Study selection, data extraction, quality assessment, and a meta-analysis were carried out. Twenty-seven studies were included in the qualitative synthesis: five randomized, eight prospective, and 14 retrospective clinical studies. One study with a serious risk of bias was later excluded. Medium and short MIs (1.4-1.9mm diameter and 5-8mm length) presented the highest success rates (0.87, 95% CI 0.80-0.92). A maximum insertion torque of 13.28Ncm (standard error 0.34) was observed for tapered self-drilling MIs in the mandible, whereas cylindrical MIs in the maxilla presented a maximum removal torque of 10.01Ncm (standard error 0.17). Moderate evidence indicates that the clinical performance of MIs is influenced by implant geometry parameters and is also related to properties of the insertion site. However, further research is necessary to support these associations. Copyright © 2017 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Raoult, Nina M.; Jupp, Tim E.; Cox, Peter M.

Land-surface models (LSMs) are crucial components of the Earth system models (ESMs) that are used to make coupled climate–carbon cycle projections for the 21st century. The Joint UK Land Environment Simulator (JULES) is the land-surface model used in the climate and weather forecast models of the UK Met Office. JULES is also extensively used offline as a land-surface impacts tool, forced with climatologies into the future. In this study, JULES is automatically differentiated with respect to JULES parameters using commercial software from FastOpt, resulting in an analytical gradient, or adjoint, of the model. Using this adjoint, the adJULES parameter estimationmore » system has been developed to search for locally optimum parameters by calibrating against observations. This paper describes adJULES in a data assimilation framework and demonstrates its ability to improve the model–data fit using eddy-covariance measurements of gross primary production (GPP) and latent heat (LE) fluxes. adJULES also has the ability to calibrate over multiple sites simultaneously. This feature is used to define new optimised parameter values for the five plant functional types (PFTs) in JULES. The optimised PFT-specific parameters improve the performance of JULES at over 85 % of the sites used in the study, at both the calibration and evaluation stages. Furthermore, the new improved parameters for JULES are presented along with the associated uncertainties for each parameter.« less

Estimating the Effective Sample Size of Tree Topologies from Bayesian Phylogenetic Analyses

PubMed Central

Lanfear, Robert; Hua, Xia; Warren, Dan L.

2016-01-01

Bayesian phylogenetic analyses estimate posterior distributions of phylogenetic tree topologies and other parameters using Markov chain Monte Carlo (MCMC) methods. Before making inferences from these distributions, it is important to assess their adequacy. To this end, the effective sample size (ESS) estimates how many truly independent samples of a given parameter the output of the MCMC represents. The ESS of a parameter is frequently much lower than the number of samples taken from the MCMC because sequential samples from the chain can be non-independent due to autocorrelation. Typically, phylogeneticists use a rule of thumb that the ESS of all parameters should be greater than 200. However, we have no method to calculate an ESS of tree topology samples, despite the fact that the tree topology is often the parameter of primary interest and is almost always central to the estimation of other parameters. That is, we lack a method to determine whether we have adequately sampled one of the most important parameters in our analyses. In this study, we address this problem by developing methods to estimate the ESS for tree topologies. We combine these methods with two new diagnostic plots for assessing posterior samples of tree topologies, and compare their performance on simulated and empirical data sets. Combined, the methods we present provide new ways to assess the mixing and convergence of phylogenetic tree topologies in Bayesian MCMC analyses. PMID:27435794

Development and evaluation of a monitoring-aid system for a nuclear power plant in control room system manipulation.

PubMed

Lin, Jhih-Tsong; Chen, Yan-Cheng; Wu, Shih-Chieh; Hwang, Sheue-Ling

2017-01-01

In an advanced nuclear power plant (NPP), the operators are responsible for monitoring a massive number of alarm parameters. To assist the operators, a monitoring-aid system (MAS), that applies four quality control chart methods, was proposed and evaluated. Two types of MAS, namely, text and graph marks, were proposed and compared with the original display. To validate the proposed MAS, 17 professional engineers and operators were invited to join an experiment. Two different system states, normal and abnormal, were simulated. The operators were asked to manipulate the system, monitor the critical parameters, search for operational procedures, and deal with other secondary tasks. The primary and secondary task performance and heart rate were measured. After each task was conducted, three subjective rating questionnaires, namely, mental workload, situation awareness, and preference ratings, were implemented for the proposed MAS and the original system. With the assistance of the MAS, the alarm detection rate, secondary task performance, and subjective mental workload demonstrate significant improvements. The proposed MAS helps the operators monitor critical parameters. Therefore, the MAS should be considered for implementation with the control panel to increase the safety of NPPs. Furthermore, the MAS could reduce the mental workload might decrease the health hazard of the operators.

Utilization-Based Modeling and Optimization for Cognitive Radio Networks

NASA Astrophysics Data System (ADS)

Liu, Yanbing; Huang, Jun; Liu, Zhangxiong

The cognitive radio technique promises to manage and allocate the scarce radio spectrum in the highly varying and disparate modern environments. This paper considers a cognitive radio scenario composed of two queues for the primary (licensed) users and cognitive (unlicensed) users. According to the Markov process, the system state equations are derived and an optimization model for the system is proposed. Next, the system performance is evaluated by calculations which show the rationality of our system model. Furthermore, discussions among different parameters for the system are presented based on the experimental results.

Pretest analysis document for Semiscale Test S-LH-1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shaw, R.A.

Results from various pretest calculations which were performed for Test S-LH-1 are included in this report. Test S-LH-1 has been designed to produce primary liquid holdup in the steam generator U-tubes similar to Tests S-UT-8. The analyses included in this report indicate liquid will be held in the tubes, the core liquid level will be appropriately depressed, and a core heater rod temperature excursion should occur. Several sensitivity studies are also included which identify parameters which could affect the response.

New Worlds Observer Telescope and Instrument Optical Design Concepts

NASA Technical Reports Server (NTRS)

Howard, Joseph; Kilston, Steve; Kendrick, Steve

2008-01-01

Optical design concepts for the telescope and instrumentation for NASA's New Worlds Observer program are presented. First order parameters are derived from the science requirements, and estimated performance metrics are shown using optical models. A four meter multiple channel telescope is discussed, as well as a suite of science instrument concepts. Wide field instrumentation (imager and spectrograph) would be accommodated by a three-mirror anastigmat telescope design. Planet finding and characterization would use a separate channel which is picked off after the first two mirrors (primary and secondary). Guiding concepts are also discussed.

Modeling Parasitic Energy Losses and the Impact of Advanced Tribological Concepts on Fuel Efficiency - Final CRADA Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fenske, George

2016-11-28

Our primary task for this project was to perform FMEP calculations for a broad range of parameters including engine type [spark ignition (SI) or compression ignition (CI)], engine size, engine mode (speed and load), lubricant viscosity, asperity friction, surface finish, oil type (mineral or synthetic), and additive (friction modifier), as discussed previously [1–3]. The actual analysis was limited to a large diesel engine and it included both load and speed dependencies as well as lubricant viscosity and speed.

Optimization of discharge circuit of the TEA CO II laser with two discharge channels

NASA Astrophysics Data System (ADS)

Hu, Xiao Yong; Zhang, LiLi; Ren, DeMing; Qu, YanChen; Zhao, WeiJiang; Song, BaoAn

2007-01-01

In order to achieve the highest peak power of radiation pulse and highest output energy, the primary circuit parameters are investigated to optimize the discharge circuit performance of the laser. The structure and the discharge circuit of the laser are discussed at first. To realize synchronous discharge in two discharge channels, the conjunct electrode device for two pairs of discharge electrodes is designed. Finally, the results of the experiments on the primary circuit parameters are given. The discharge is most stable at a pressure of 5.33×10 4Pa when the pressure of gaseous mixture CO II:N II:He=1:1:3 is changed from 2.67×10 4 Pa to 6.67×10 4 Pa. The ratio of storage capacitance to peak capacitance is chosen to be about 1.5-7/3, because residual voltage is lower on this condition and residual voltage is adverse to discharge. When the inductance 330μH is used, the homogeneous glow discharge in a widest voltage range is obtained. The duration of when the stimuli voltage is increased in homogeneous glow discharge condition. The discharge circuit allows charge and discharge and the magnitude of residual voltage decrease the homogeneous glow discharge in a wide range of pressure of gaseous mixture when these circuit parameters are used. Thus it offers reference to the improvement of output characteristic of TEA CO II laser with two discharge channels.

Assessment of liver function in primary biliary cirrhosis using Gd-EOB-DTPA-enhanced liver MRI.

PubMed

Nilsson, Henrik; Blomqvist, Lennart; Douglas, Lena; Nordell, Anders; Jonas, Eduard

2010-10-01

Gd-EOB-DTPA (gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid) is a gadolinium-based hepatocyte-specific contrast agent for magnetic resonance imaging (MRI). The aim of this study was to determine whether the hepatic uptake and excretion of Gd-EOB-DTPA differ between patients with primary biliary cirrhosis (PBC) and healthy controls, and whether differences could be quantified. Gd-EOB-DTPA-enhanced liver MRI was performed in 20 healthy volunteers and 12 patients with PBC. The uptake of Gd-EOB-DTPA was assessed using traditional semi-quantitative parameters (C(max) , T(max) and T(1/2) ), as well as model-free parameters derived after deconvolutional analysis (hepatic extraction fraction [HEF], input-relative blood flow [irBF] and mean transit time [MTT]). In each individual, all parameters were calculated for each liver segment and the median of the segmental values was used to define a global liver median (GLM). Although the PBC patients had relatively mild disease according to their Model for End-stage Liver Disease (MELD), Child-Pugh and Mayo risk scores, they had significantly lower HEF and shorter MTT values compared with the healthy controls. These differences significantly increased with increasing MELD and Child-Pugh scores. Dynamic hepatocyte-specific contrast-enhanced MRI (DHCE-MRI) has a potential role as an imaging-based liver function test. The high spatial resolution of MRI enables hepatic function to be assessed on segmental and sub-segmental levels. © 2010 International Hepato-Pancreato-Biliary Association.

Doppler echocardiographic myocardial stunning index predicts recovery of left ventricular systolic function after primary percutaneous coronary intervention.

PubMed

Sharif, Dawod; Matanis, Wisam; Sharif-Rasslan, Amal; Rosenschein, Uri

2016-10-01

Myocardial stunning is responsible for partially reversible left ventricular (LV) systolic dysfunction after successful primary percutaneous coronary intervention (PPCI) in patients with acute ST-elevation myocardial infarction (STEMI). To test the hypothesis that early coronary blood flow (CBF) to LV systolic function ratios, as an equivalent to LV stunning index (SI), predict recovery of LV systolic function after PPCI in patients with acute STEMI. Twenty-four patients with acute anterior STEMI who had successful PPCI were evaluated and compared to 96 control subjects. Transthoracic echocardiography with measurement of LV ejection fraction (EF), LV, and left anterior descending (LAD) coronary artery area wall-motion score index (WMSI) as well as Doppler sampling of LAD blood velocities, early after PPCI and 5 days later, were performed. SI was evaluated as the early ratio of CBF parameters in the LAD to LV systolic function parameters. Early SI-LVEF well predicted late LVEF (r=.51, P<.01) and the change in LVEF (r=.48, P<.017). Early SI-LVMSI predicted well late LVEF (r=.56, P<.006) and the change in LVEF (r=.46, P<.028). Early SI-LADWMSI predicted late LVEF (r=.44, P<.028). Other SI indices measured as other LAD-CBF to LV systolic function parameters were not predictive of late LV systolic function. LV stunning indices measured as early LAD flow to LVEF, LVWMSI, and LADWMSI ratios well predicted late LVEF and the change in LVEF. Thus, greater early coronary artery flow to LV systolic function parameter ratios predict a better improvement in late LV systolic function after PPCI. © 2016, Wiley Periodicals, Inc.

Dynamical photoionization observables of the CS molecule: The role of electron correlation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ponzi, Aurora; Coriani, Sonia; Decleva, Piero

2014-05-28

Highly correlated calculations are performed on the primary ionic states and the prominent satellite present in the outer valence photoelectron spectrum of carbon monosulfide (CS). Dyson orbitals are coupled to accurate one particle continuum orbitals to provide a correlated description of energy dependent cross sections, asymmetry parameters, branching ratios, and molecular frame photoelectron angular distributions. The comparison with results obtained at the Hartree-Fock and Density Functional Theory level shows the strong sensitivity of these observables to details of the correlation in the bound states. The behaviour of the well characterized satellite state is analyzed in detail, and shows differences frommore » the relevant primary states, revealing the limitations of a simple intensity borrowing mechanism. The results resolve the intensity disagreement with experiment obtained at the level of the sudden approximation.« less

High temperature superconductors applications in telecommunications

NASA Technical Reports Server (NTRS)

Kumar, A. Anil; Li, Jiang; Zhang, Ming Fang

1995-01-01

The purpose of this paper is twofold: (1) to discuss high temperature superconductors with specific reference to their employment in telecommunications applications; and (2) to discuss a few of the limitations of the normally employed two-fluid model. While the debate on the actual usage of high temperature superconductors in the design of electronic and telecommunications devices - obvious advantages versus practical difficulties - needs to be settled in the near future, it is of great interest to investigate the parameters and the assumptions that will be employed in such designs. This paper deals with the issue of providing the microwave design engineer with performance data for such superconducting waveguides. The values of conductivity and surface resistance, which are the primary determining factors of a waveguide performance, are computed based on the two-fluid model. A comparison between two models - a theoretical one in terms of microscopic parameters (termed Model A) and an experimental fit in terms of macroscopic parameters (termed Model B) - shows the limitations and the resulting ambiguities of the two-fluid model at high frequencies and at temperatures close to the transition temperature. The validity of the two-fluid model is then discussed. Our preliminary results show that the electrical transport description in the normal and superconducting phases as they are formulated in the two-fluid model needs to be modified to incorporate the new and special features of high temperature superconductors. Parameters describing the waveguide performance - conductivity, surface resistance and attenuation constant - will be computed. Potential applications in communications networks and large scale integrated circuits will be discussed. Some of the ongoing work will be reported. In particular, a brief proposal is made to investigate of the effects of electromagnetic interference and the concomitant notion of electromagnetic compatibility (EMI/EMC) of high T(sub c) superconductors.

High temperature superconductors applications in telecommunications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kumar, A.A.; Li, J.; Zhang, M.F.

1994-12-31

The purpose of this paper is twofold: to discuss high temperature superconductors with specific reference to their employment in telecommunications applications; and to discuss a few of the limitations of the normally employed two-fluid model. While the debate on the actual usage of high temperature superconductors in the design of electronic and telecommunications devices-obvious advantages versus practical difficulties-needs to be settled in the near future, it is of great interest to investigate the parameters and the assumptions that will be employed in such designs. This paper deals with the issue of providing the microwave design engineer with performance data formore » such superconducting waveguides. The values of conductivity and surface resistance, which are the primary determining factors of a waveguide performance, are computed based on the two-fluid model. A comparison between two models-a theoretical one in terms of microscopic parameters (termed Model A) and an experimental fit in terms of macroscopic parameters (termed Model B)-shows the limitations and the resulting ambiguities of the two-fluid model at high frequencies and at temperatures close to the transition temperature. The validity of the two-fluid model is then discussed. Our preliminary results show that the electrical transport description in the normal and superconducting phases as they are formulated in the two-fluid model needs to be modified to incorporate the new and special features of high temperature superconductors. Parameters describing the waveguide performance-conductivity, surface resistance and attenuation constant-will be computed. Potential applications in communications networks and large scale integrated circuits will be discussed. Some of the ongoing work will be reported. In particular, a brief proposal is made to investigate of the effects of electromagnetic interference and the concomitant notion of electromagnetic compatibility (EMI/EMC) of high T{sub c} superconductors.« less

Global-scale combustion sources of organic aerosols: sensitivity to formation and removal mechanisms

NASA Astrophysics Data System (ADS)

Tsimpidi, Alexandra P.; Karydis, Vlassis A.; Pandis, Spyros N.; Lelieveld, Jos

2017-06-01

Organic compounds from combustion sources such as biomass burning and fossil fuel use are major contributors to the global atmospheric load of aerosols. We analyzed the sensitivity of model-predicted global-scale organic aerosols (OA) to parameters that control primary emissions, photochemical aging, and the scavenging efficiency of organic vapors. We used a computationally efficient module for the description of OA composition and evolution in the atmosphere (ORACLE) of the global chemistry-climate model EMAC (ECHAM/MESSy Atmospheric Chemistry). A global dataset of aerosol mass spectrometer (AMS) measurements was used to evaluate simulated primary (POA) and secondary (SOA) OA concentrations. Model results are sensitive to the emission rates of intermediate-volatility organic compounds (IVOCs) and POA. Assuming enhanced reactivity of semi-volatile organic compounds (SVOCs) and IVOCs with OH substantially improved the model performance for SOA. The use of a hybrid approach for the parameterization of the aging of IVOCs had a small effect on predicted SOA levels. The model performance improved by assuming that freshly emitted organic compounds are relatively hydrophobic and become increasingly hygroscopic due to oxidation.

Monitoring of magnetic nano-particles in EOR by using the CSEM modeling and inversion.

NASA Astrophysics Data System (ADS)

Heo, J. Y.; KIM, S.; Jeong, G.; Hwang, J.; Min, D. J.

2016-12-01

EOR, which injects water, CO2, or other chemical components into reservoirs to increase the production rate of oil and gas, has widely been used. To promote efficiency of EOR, it is important to monitor distribution of injected materials in reservoirs. Using nano-particles in EOR has advantages that the size of particles is smaller than the pore and particles can be characterized by various physical properties. Specifically, if we use magnetic nano-particles, we can effectively monitor nano-particles by using the electromagnetic survey. CSEM, which can control the frequency range of source, is good to monitor magnetic nano-particles under various reservoir circumstances. In this study, we first perform numerical simulation of 3D CSEM for reservoir under production. In general, two wells are used for EOR: one is for injection, and the other is for extraction. We assume that sources are applied inside the injection well, and receivers are deployed inside the extraction well. To simulate the CSEM survey, we decompose the total fields into primary and secondary fields in Maxwell's equations. For the primary fields, we calculate the analytic solutions of the layered earth. With the calculated primary fields, we compute the secondary fields due to anomalies using the edge-based finite-element method. Finally, we perform electromagnetic inversion for both conductivity and permeability to trace the distribution of magnetic nano-particles. Since these two parameters react differently according to the frequency range of sources, we can effectively describe the distribution of magnetic nano-particles by considering two parameters at the same time. Acknowledgements This work was supported by the Korea Institute of Energy Technology Evaluation and Planning(KETEP) and the Ministry of Trade, Industry & Energy(MOTIE) of the Republic of Korea (No. 20168510030830), and by the International Cooperation (No. 2012-8510030010) of KETEP, and by the Dual Use Technology Program, granted financial resource from the MOTIE.

Support optimization of the ring primary mirror of a 2m solar telescope

NASA Astrophysics Data System (ADS)

Yang, Dehua; Jin, Zhenyu; Liu, Zhong

2016-08-01

A special 2-m Ring Solar Telescope (2-m RST) is to be built by YNAO-Yunnan Astronomical Observatory, Kunming, China. Its distinct primary mirror is distinctively shaped in a ring with an outer diameter of 2.02 m and a ring width of 0.35 m. Careful calculation and optimization of the mirror support pattern have been carried out first of all to define optimum blank parameters in view of performance balance of support design, fabrication and cost. This paper is to review the special consideration and optimization of the support design for the unique ring mirror. Schott zerodur is the prevailing candidate for the primary mirror blank. Diverse support patterns with various blank thicknesses have been discussed by extensive calculation of axial support pattern of the mirror. We reached an optimum design of 36 axial supports for a blank thickness of 0.15 m with surface error of 5 nm RMS. Afterwards, lateral support scheme was figured out for the mirror with settled parameters. A classical push-and-pull scheme was used. Seeing the relative flexibility of the ring mirror, special consideration was taken to unusually set the acting direction of the support forces not in the mirror gravity plane, but along the gravity of the local virtual slices of the mirror blank. Nine couples of the lateral push-pull force are considered. When pointing to horizon, the mirror surface exhibits RMS error of 5 nm with three additional small force couples used to compensate for the predominant astigmatism introduced by lateral supports. Finally, error estimation has been performed to evaluate the surface degradation with introduced errors in support force and support position, respectively, for both axial and lateral supports. Monte Carlo approach was applied using unit seeds for amplitude and position of support forces. The comprehensive optimization and calculation suggests the support systems design meet the technic requirements of the ring mirror of the 2-m RST.

Integration of Host Strain Bioengineering and Bioprocess Development Using Ultra-Scale Down Studies to Select the Optimum Combination: An Antibody Fragment Primary Recovery Case Study

PubMed Central

Aucamp, Jean P; Davies, Richard; Hallet, Damien; Weiss, Amanda; Titchener-Hooker, Nigel J

2014-01-01

An ultra scale-down primary recovery sequence was established for a platform E. coli Fab production process. It was used to evaluate the process robustness of various bioengineered strains. Centrifugal discharge in the initial dewatering stage was determined to be the major cause of cell breakage. The ability of cells to resist breakage was dependant on a combination of factors including host strain, vector, and fermentation strategy. Periplasmic extraction studies were conducted in shake flasks and it was demonstrated that key performance parameters such as Fab titre and nucleic acid concentrations were mimicked. The shake flask system also captured particle aggregation effects seen in a large scale stirred vessel, reproducing the fine particle size distribution that impacts the final centrifugal clarification stage. The use of scale-down primary recovery process sequences can be used to screen a larger number of engineered strains. This can lead to closer integration with and better feedback between strain development, fermentation development, and primary recovery studies. Biotechnol. Bioeng. 2014;111: 1971–1981. © 2014 Wiley Periodicals, Inc. PMID:24838387

Hypersonic research engine project. Phase 2: Preliminary report on the performance of the HRE/AIM at Mach 6

NASA Technical Reports Server (NTRS)

Sun, Y. H.; Sainio, W. C.

1975-01-01

Test results of the Aerothermodynamic Integration Model are presented. A program was initiated to develop a hydrogen-fueled research-oriented scramjet for operation between Mach 3 and 8. The primary objectives were to investigate the internal aerothermodynamic characteristics of the engine, to provide realistic design parameters for future hypersonic engine development as well as to evaluate the ground test facility and testing techniques. The engine was tested at the NASA hypersonic tunnel facility with synthetic air at Mach 5, 6, and 7. The hydrogen fuel was heated up to 1500 R prior to injection to simulate a regeneratively cooled system. The engine and component performance at Mach 6 is reported. Inlet performance compared very well both with theory and with subscale model tests. Combustor efficiencies up to 95 percent were attained at an equivalence ratio of unity. Nozzle performance was lower than expected. The overall engine performance was computed using two different methods. The performance was also compared with test data from other sources.

[Primary care follow-up of newborns with sickle cell disease detected in neonatal screening in the Community of Madrid].

PubMed

Rodríguez-Moldes, B; Carbajo, A J; Sánchez, B; Fernández, M; Garí, M; Fernández, M C; Álvarez, J; García, A; Cela, E

2015-04-01

The main aim of the study was to assess the effects of the recommended preventive program in the population affected with Sickle Cell Disease in Primary Care. The program included, antibiotic prophylaxis, immunizations and health education, following the introduction of universal neonatal screening program for Sickle Cell Disease in the Community of Madrid. A cross-sectional observational study was performed with retrospective data collected from a cohort of newborns with Sickle Cell Disease diagnosed by neonatal screening test in the Community of Madrid. From the data obtained from a sample of 20 patients, it was found that 95% had been diagnosed by the newborn screening test performed between 5 and 13 days of life. The mean age was 39 months when the study was conducted. During follow-up, from Primary Care Paediatric clinic, it was observed that the compliance for antibiotic prophylaxis was 90%, and the coverage for the official vaccination schedule was 85%. Specific vaccine coverage as a risk population was highly variable (85% for pneumococcal 23V, 50% for influenza, and 15% for hepatitis A). Health education only reached one in every four families. Acceptable compliance with antibiotic prophylaxis was observed during the follow-up of patients with sickle cell disease in Primary Care, but a low coverage of routine immunization, as well as specific immunizations. Coverage of health education was very low. Improving these parameters would require greater coordination and involvement of Primary Care Professionals so that these patients were followed up appropriately, and could be translated into a reduction of disease complications and an improvement in the quality of life of these patients. Copyright © 2013 Asociación Española de Pediatría. Published by Elsevier España, S.L.U. All rights reserved.

The Treatment of Restless Legs Syndrome and Periodic Limb Movement Disorder in Adults—An Update for 2012: Practice Parameters with an Evidence-Based Systematic Review and Meta-Analyses

PubMed Central

Aurora, R. Nisha; Kristo, David A.; Bista, Sabin R.; Rowley, James A.; Zak, Rochelle S.; Casey, Kenneth R.; Lamm, Carin I.; Tracy, Sharon L.; Rosenberg, Richard S.

2012-01-01

A systematic literature review and meta-analyses (where appropriate) were performed to update the previous AASM practice parameters on the treatments, both dopaminergic and other, of RLS and PLMD. A considerable amount of literature has been published since these previous reviews were performed, necessitating an update of the corresponding practice parameters. Therapies with a STANDARD level of recommendation include pramipexole and ropinirole. Therapies with a GUIDELINE level of recommendation include levodopa with dopa decarboxylase inhibitor, opioids, gabapentin enacarbil, and cabergoline (which has additional caveats for use). Therapies with an OPTION level of recommendation include carbamazepine, gabapentin, pregabalin, clonidine, and for patients with low ferritin levels, iron supplementation. The committee recommends a STANDARD AGAINST the use of pergolide because of the risks of heart valve damage. Therapies for RLS secondary to ESRD, neuropathy, and superficial venous insufficiency are discussed. Lastly, therapies for PLMD are reviewed. However, it should be mentioned that because PLMD therapy typically mimics RLS therapy, the primary focus of this review is therapy for idiopathic RLS. Citation: Aurora RN; Kristo DA; Bista SR; Rowley JA: Zak RS; Casey KR; Lamm CI; Tracy SL; Rosenberg RS. The treatment of restless legs syndrome and periodic limb movement disorder in adults—an update for 2012: practice parameters with an evidence-based systematic review and meta-analyses. SLEEP 2012;35(8):1039-1062. PMID:22851801

Land-surface parameter optimisation using data assimilation techniques: the adJULES system V1.0

DOE PAGES

Raoult, Nina M.; Jupp, Tim E.; Cox, Peter M.; ...

2016-08-25

Land-surface models (LSMs) are crucial components of the Earth system models (ESMs) that are used to make coupled climate–carbon cycle projections for the 21st century. The Joint UK Land Environment Simulator (JULES) is the land-surface model used in the climate and weather forecast models of the UK Met Office. JULES is also extensively used offline as a land-surface impacts tool, forced with climatologies into the future. In this study, JULES is automatically differentiated with respect to JULES parameters using commercial software from FastOpt, resulting in an analytical gradient, or adjoint, of the model. Using this adjoint, the adJULES parameter estimationmore » system has been developed to search for locally optimum parameters by calibrating against observations. This paper describes adJULES in a data assimilation framework and demonstrates its ability to improve the model–data fit using eddy-covariance measurements of gross primary production (GPP) and latent heat (LE) fluxes. adJULES also has the ability to calibrate over multiple sites simultaneously. This feature is used to define new optimised parameter values for the five plant functional types (PFTs) in JULES. The optimised PFT-specific parameters improve the performance of JULES at over 85 % of the sites used in the study, at both the calibration and evaluation stages. Furthermore, the new improved parameters for JULES are presented along with the associated uncertainties for each parameter.« less

Accurate study on the properties of spectral lines for Br-like W39+

NASA Astrophysics Data System (ADS)

Guo, X. L.; Li, M. C.; Si, R.; He, X. D.; Wang, K.; Dai, Z. T.; Liu, Y. M.; Zhang, H. J.; Chen, C. Y.

2018-01-01

As a primary candidate in tokamak plasmas, the spectroscopic parameters of tungsten ions have been studied extensively over the past decade. In this paper, we perform calculations of excitation energies, lifetimes, wavelengths and transition rates for all levels of the 4{s}24{p}5, 4{s}24{p}44d, and 4s4{p}6 configurations of {{{W}}}39+ by using the multiconfiguration Dirac-Hartree-Fock (MCDHF) method, and also the relativistic many-body perturbation theory (RMBPT) method. Detailed convergence studies on excitation energy from electron-correlation effects and relativistic effects are presented. It is necessary to include the core-valence correlation from deep lying subshells, e.g. 3d and 3p, to produce reliable atomic parameters. Results are compared with available theoretical and experimental work, and the accuracy of the results is confirmed.

High Thrust-to-Power Annular Engine Technology

NASA Technical Reports Server (NTRS)

Patterson, Michael J.; Thomas, Robert E.; Crofton, Mark W.; Young, Jason A.; Foster, John E.

2015-01-01

Gridded ion engines have the highest efficiency and total impulse of any mature electric propulsion technology, and have been successfully implemented for primary propulsion in both geocentric and heliocentric environments with excellent ground/in-space correlation of performance. However, they have not been optimized to maximize thrust-to-power, an important parameter for Earth orbit transfer applications. This publication discusses technology development work intended to maximize this parameter. These activities include investigating the capabilities of a non-conventional design approach, the annular engine, which has the potential of exceeding the thrust-to-power of other EP technologies. This publication discusses the status of this work, including the fabrication and initial tests of a large-area annular engine. This work is being conducted in collaboration among NASA Glenn Research Center, The Aerospace Corporation, and the University of Michigan.

High Thrust-to-Power Annular Engine Technology

NASA Technical Reports Server (NTRS)

Patterson, Michael; Thomas, Robert; Crofton, Mark; Young, Jason A.; Foster, John E.

2015-01-01

Gridded ion engines have the highest efficiency and total impulse of any mature electric propulsion technology, and have been successfully implemented for primary propulsion in both geocentric and heliocentric environments with excellent ground-in-space correlation of performance. However, they have not been optimized to maximize thrust-to-power, an important parameter for Earth orbit transfer applications. This publication discusses technology development work intended to maximize this parameter. These activities include investigating the capabilities of a non-conventional design approach, the annular engine, which has the potential of exceeding the thrust-to-power of other EP technologies. This publication discusses the status of this work, including the fabrication and initial tests of a large-area annular engine. This work is being conducted in collaboration among NASA Glenn Research Center, The Aerospace Corporation, and the University of Michigan.

General study of asymmetrical crossed Czerny-Turner spectrometer.

PubMed

Tang, Ming; Fan, Xianguang; Wang, Xin; Xu, Yingjie; Que, Jing; He, Jian

2015-11-20

A study of the spectrum resolution, wavelength range, and primary aberration of the asymmetrical crossed Czerny-Turner spectrometer is presented by deducing the relationship between them and structural parameters of the spectrometer in a new way of thinking based on simple but effective geometric models. The analysis was verified in an experiment and simulation performed on the optical design program ZEMAX, and the obtained results agree with the analysis. Owing to the analysis, initial designed parameters of the spectrometer were given and then optimized by ZEMAX; with the instruction of the study, a small adjustment was made in the actual alignment to obtain the desired final spectrometer. The spectrometer successfully measured the last four characteristic peaks of the Raman spectrum of CCL4, which demonstrates that the research provides important guidance to the design and alignment of an asymmetrical crossed Czerny-Turner spectrometer.

Influence of structural parameters on the tendency of VVER-1000 reactor pressure vessel steel to temper embrittlement

NASA Astrophysics Data System (ADS)

Gurovich, B.; Kuleshova, E.; Zabusov, O.; Fedotova, S.; Frolov, A.; Saltykov, M.; Maltsev, D.

2013-04-01

In this paper the influence of structural parameters on the tendency of steels to reversible temper embrittlement was studied for assessment of performance properties of reactor pressure vessel steels with extended service life. It is shown that the growth of prior austenite grain size leads to an increase of the critical embrittlement temperature in the initial state. An embrittlement heat treatment at the temperature of maximum manifestation of temper embrittlement (480 °C) shifts critical embrittlement temperature to higher values due to the increase of the phosphorus concentration on grain boundaries. There is a correlation between phosphorus concentration on boundaries of primary austenite grains and the share of brittle intergranular fracture (that, in turn, depends on impact test temperature) in the fracture surfaces of the tested Charpy specimens.

Space flight risk data collection and analysis project: Risk and reliability database

NASA Technical Reports Server (NTRS)

1994-01-01

The focus of the NASA 'Space Flight Risk Data Collection and Analysis' project was to acquire and evaluate space flight data with the express purpose of establishing a database containing measurements of specific risk assessment - reliability - availability - maintainability - supportability (RRAMS) parameters. The developed comprehensive RRAMS database will support the performance of future NASA and aerospace industry risk and reliability studies. One of the primary goals has been to acquire unprocessed information relating to the reliability and availability of launch vehicles and the subsystems and components thereof from the 45th Space Wing (formerly Eastern Space and Missile Command -ESMC) at Patrick Air Force Base. After evaluating and analyzing this information, it was encoded in terms of parameters pertinent to ascertaining reliability and availability statistics, and then assembled into an appropriate database structure.

One way Doppler extractor. Volume 1: Vernier technique

NASA Technical Reports Server (NTRS)

Blasco, R. W.; Klein, S.; Nossen, E. J.; Starner, E. R.; Yanosov, J. A.

1974-01-01

A feasibility analysis, trade-offs, and implementation for a One Way Doppler Extraction system are discussed. A Doppler error analysis shows that quantization error is a primary source of Doppler measurement error. Several competing extraction techniques are compared and a Vernier technique is developed which obtains high Doppler resolution with low speed logic. Parameter trade-offs and sensitivities for the Vernier technique are analyzed, leading to a hardware design configuration. A detailed design, operation, and performance evaluation of the resulting breadboard model is presented which verifies the theoretical performance predictions. Performance tests have verified that the breadboard is capable of extracting Doppler, on an S-band signal, to an accuracy of less than 0.02 Hertz for a one second averaging period. This corresponds to a range rate error of no more than 3 millimeters per second.

[The significance of pedigree genetic screening and rapid immunological parameters in the diagnosis of primary hemophagocytic lymphohistiocytosis].

PubMed

Zhang, J; Wang, Y N; Wang, J S; Wu, L; Wei, N; Fu, L; Gao, Z; Chen, J H; Pei, R J; Wang, Z

2016-07-01

To investigate the significance of pedigree genetic screening and rapid immunological parameters in the diagnosis of primary hemophagocytic lymphohistiocytosis (HLH). Four cases of primary HLH patients with PRF1, UNC13D and SH2D1A gene mutations were conducted pedigree investigation, including family genetic screening and detections of immunological parameters (NK cell activity, CD107a degranulation and expression of HLH related defective protein), to evaluate the significance of these different indicators in the diagnosis of primary HLH and explore their correlations. The DNA mutations of the four families included missense mutation c.T172C (p.S58P) and non- frameshift deletions c.1083_1094del (p.361_365del), missense mutation c.C1349T (p.T450M) and frameshift mutation c.1090_1091delCT (p.T364fsX93) in PRF1 gene, missense mutation c.G2588A (p.G863D) in UNC13D gene and hemizygous mutation c.32T>G (p.I11S) in SH2D1A gene. The patients and their family members presented decreased NK cell activities. Individuals who carried mutations of PRF1 gene and SH2D1A gene showed low expression of perforin (PRF1) and signaling lymphocytic activation molecule associated protein (SAP). And the patient with UNC13D gene mutation and his family member with identical mutation showed significant reducing cytotoxic degranulation function (expression of CD107a). Pedigree genetic screening and rapid detection of immunological parameters might play an important role in the diagnosis of primary HLH, and both of them had good consistency. As an efficient detection means, the rapid immunological detection indicators would provide reliable basis for the early diagnosis of the primary HLH.

A clinical study of the LiVac laparoscopic liver retractor system.

PubMed

Gan, Philip; Bingham, Judy

2016-02-01

All retractors for laparoscopic operations on the gallbladder or stomach apply an upward force to the under-surface of the liver or gallbladder, most requiring an additional skin incision. The LiVac laparoscopic liver retractor system (LiVac retractor) comprises a soft silicone ring attached to suction tubing and connected to a regulated source of suction. The suction tubing extends alongside existing ports. When placed between the liver and diaphragm, and suction applied, a vacuum is created within the ring, keeping these in apposition. Following successful proof-of-concept animal testing, a clinical study was conducted to evaluate the performance and safety of the retractor in patients. The study was a dual-centre, single-surgeon, open-label study and recruited ten patients scheduled to undergo routine upper abdominal laparoscopic surgery including cholecystectomy, primary gastric banding surgery or fundoplication. The study was conducted at two sites and was approved by the institutions' ethics committees. The primary objective of the study was to evaluate the performance of the LiVac retractor in patients undergoing upper abdominal single- or multi-port laparoscopic surgery. Performance was measured by the attainment of milestones for the retractor and accessory bevel, where used, and safety outcomes through the recording of adverse events, physical parameters, pain scales, blood tests and a post-operative liver ultrasound. The LiVac retractor achieved both primary and secondary performance and safety objectives in all patients. No serious adverse events and no device-related adverse events or device deficiencies were reported. The LiVac retractor achieved effective liver retraction without clinically significant trauma and has potential application in multi- or single-port laparoscopic upper abdominal surgery. As a separate incision is not required, the use of the LiVac retractor in multi-port surgery therefore reduces the number of incisions.

Parametric uncertainties in global model simulations of black carbon column mass concentration

NASA Astrophysics Data System (ADS)

Pearce, Hana; Lee, Lindsay; Reddington, Carly; Carslaw, Ken; Mann, Graham

2016-04-01

Previous studies have deduced that the annual mean direct radiative forcing from black carbon (BC) aerosol may regionally be up to 5 W m-2 larger than expected due to underestimation of global atmospheric BC absorption in models. We have identified the magnitude and important sources of parametric uncertainty in simulations of BC column mass concentration from a global aerosol microphysics model (GLOMAP-Mode). A variance-based uncertainty analysis of 28 parameters has been performed, based on statistical emulators trained on model output from GLOMAP-Mode. This is the largest number of uncertain model parameters to be considered in a BC uncertainty analysis to date and covers primary aerosol emissions, microphysical processes and structural parameters related to the aerosol size distribution. We will present several recommendations for further research to improve the fidelity of simulated BC. In brief, we find that the standard deviation around the simulated mean annual BC column mass concentration varies globally between 2.5 x 10-9 g cm-2 in remote marine regions and 1.25 x 10-6 g cm-2 near emission sources due to parameter uncertainty Between 60 and 90% of the variance over source regions is due to uncertainty associated with primary BC emission fluxes, including biomass burning, fossil fuel and biofuel emissions. While the contributions to BC column uncertainty from microphysical processes, for example those related to dry and wet deposition, are increased over remote regions, we find that emissions still make an important contribution in these areas. It is likely, however, that the importance of structural model error, i.e. differences between models, is greater than parametric uncertainty. We have extended our analysis to emulate vertical BC profiles at several locations in the mid-Pacific Ocean and identify the parameters contributing to uncertainty in the vertical distribution of black carbon at these locations. We will present preliminary comparisons of emulated BC vertical profiles from the AeroCom multi-model ensemble and Hiaper Pole-to-Pole (HIPPO) observations.

On the dynamics of a small body under the influence of a Maxwell ring-type N-body system with a spheroidal central body: Focal curves

NASA Astrophysics Data System (ADS)

Kalvouridis, T.; Fakis, D.

2013-09-01

One of the most interesting aspects which characterize the dynamics of a small body under the influence of a regular polygon formation of N bodies with a spheroidal central primary, is related to the zero-velocity surfaces which, for a given set of the problem's parameters, separate the regions where particle planar motion is permitted from those where this motion is impossible. The non-sphericity of the central primary is here described by adding an inverse cube corrective term to Newton's law of gravitation, when applied both between the central primary and a peripheral one and between this primary and the small body. A similar expression of the potential including a corrective term was proposed by Manev in 1924 in his effort to describe some special physical properties of a body like radiation emission, or to explain some relativistic effects without using the theory of relativity. The version of the problem we deal with, is characterized by three parameters, namely, the number ?=N-1 of the peripheral primaries, the mass parameter (ratio of the central mass m0 to the mass m of a peripheral body) and the oblateness parameter e, which appears in the non-Newtonian term of the force function related to the central primary. Parameter ? takes only positive values, while parameter e can take small real values either positive (oblate body) or negative (prolate body). By using the existing Jacobian-type integral which characterizes the planar motion of the particle in the synodic coordinate system Oxyz located at the mass center O of the system, and by superposing the zerovelocity surfaces C=C(x,y, z=0; ?, e) (where C is the Jacobian constant) drawn for a given configuration ?, we observe that: (i) when e is kept constant and ? varies, then the central parts of all these surfaces ,which evolve around the central primary, intersect along one continuous curve while, (ii) when ? is kept constant and e varies, then, depending on either positive or negative values of e, the central parts of all these surfaces intersect along either one or two common continuous curves respectively. We call these curves focal curves due to their aforementioned property. As it is expected, they display all the symmetry elements of the primaries arrangement in rotations around an axis perpendicular to the xy-plane through an angle 2?/?. We shall prove that in case (i) the focal curve is independent of parameter e, while in case (ii) the focal curves (or curve) are independent of parameter ?. It should be noted that, a similar property concerning the zero-velocity surfaces has been discovered by one of the present authors (Kalvouridis, 2004) during the investigation of the particle dynamics in the Newtonian field of a regular polygon formation of N spherical massive bodies. Another aspect dealt with in the present paper, is the mechanism of the parametric evolution of the focal curves and the effects of this property on the equilibrium locations and the periodic motions of the particle.

Statistical Analysis of Deflation in Covariance and Resultant Pc Values for AQUA, AURA and TERRA

NASA Technical Reports Server (NTRS)

Hasan, Syed O.

2016-01-01

This presentation will display statistical analysis performed for raw conjunction CDMs received for the EOS Aqua, Aura and Terra satellites within the period of February 2015 through July 2016. The analysis performed indicates a discernable deflation in covariance calculated at the JSpOC after the utilization of the dynamic drag consider parameter was implemented operationally in May 2015. As a result, the overall diminution in the conjunction plane intersection of the primary and secondary objects appears to be leading to reduced probability of collision (Pc) values for these conjunction events. This presentation also displays evidence for this theory with analysis of Pc trending plots using data calculated by the SpaceNav CRMS system.

Trajectory optimization for the National Aerospace Plane

NASA Technical Reports Server (NTRS)

Lu, Ping

1992-01-01

The primary objective of this research is to develop an efficient and robust trajectory optimization tool for the optimal ascent problem of the National Aerospace Plane (NASP). This report is organized in the following order to summarize the complete work: Section two states the formulation and models of the trajectory optimization problem. An inverse dynamics approach to the problem is introduced in Section three. Optimal trajectories corresponding to various conditions and performance parameters are presented in Section four. A midcourse nonlinear feedback controller is developed in Section five. Section six demonstrates the performance of the inverse dynamics approach and midcourse controller during disturbances. Section seven discusses rocket assisted ascent which may be beneficial when orbital altitude is high. Finally, Section eight recommends areas of future research.

Genome-wide association study of swine farrowing traits. Part I: Genetic and genomic parameter estimates

USDA-ARS?s Scientific Manuscript database

The primary objective of this study was to determine genetic and genomic parameters among swine farrowing traits. Genetic parameters were obtained by using MTDFREML and genomic parameters were obtained using GenSel. Genetic and residual variances obtained from MTDFREML were used as priors for the ...

Analysis of neutron spectrum effects on primary damage in tritium breeding blankets

NASA Astrophysics Data System (ADS)

Choi, Yong Hee; Joo, Han Gyu

2012-07-01

The effect of neutron spectrum on primary damages in a structural material of a tritium breeding blanket is investigated with a newly established recoil spectrum estimation system. First, a recoil spectrum generation code is developed to obtain the energy spectrum of primary knock-on atoms (PKAs) for a given neutron spectrum utilizing the latest ENDF/B data. Secondly, a method for approximating the high energy tail of the recoil spectrum is introduced to avoid expensive molecular dynamics calculations for high energy PKAs using the concept of recoil energy of the secondary knock-on atoms originated by the INtegration of CAScades (INCAS) model. Thirdly, the modified spectrum is combined with a set of molecular dynamics calculation results to estimate the primary damage parameters such as the number of surviving point defects. Finally, the neutron spectrum is varied by changing the material of the spectral shifter and the result in primary damage parameters is examined.

Simplified, rapid, and inexpensive estimation of water primary productivity based on chlorophyll fluorescence parameter Fo.

PubMed

Chen, Hui; Zhou, Wei; Chen, Weixian; Xie, Wei; Jiang, Liping; Liang, Qinlang; Huang, Mingjun; Wu, Zongwen; Wang, Qiang

2017-04-01

Primary productivity in water environment relies on the photosynthetic production of microalgae. Chlorophyll fluorescence is widely used to detect the growth status and photosynthetic efficiency of microalgae. In this study, a method was established to determine the Chl a content, cell density of microalgae, and water primary productivity by measuring chlorophyll fluorescence parameter Fo. A significant linear relationship between chlorophyll fluorescence parameter Fo and Chl a content of microalgae, as well as between Fo and cell density, was observed under pure-culture conditions. Furthermore, water samples collected from natural aquaculture ponds were used to validate the correlation between Fo and water primary productivity, which is closely related to Chl a content in water. Thus, for a given pure culture of microalgae or phytoplankton (mainly microalgae) in aquaculture ponds or other natural ponds for which the relationship between the Fo value and Chl a content or cell density could be established, Chl a content or cell density could be determined by measuring the Fo value, thereby making it possible to calculate the water primary productivity. It is believed that this method can provide a convenient way of efficiently estimating the primary productivity in natural aquaculture ponds and bringing economic value in limnetic ecology assessment, as well as in algal bloom monitoring. Copyright © 2017 Elsevier GmbH. All rights reserved.

Processes influencing model-data mismatch in drought-stressed, fire-disturbed eddy flux sites

NASA Astrophysics Data System (ADS)

Mitchell, Stephen; Beven, Keith; Freer, Jim; Law, Beverly

2011-06-01

Semiarid forests are very sensitive to climatic change and among the most difficult ecosystems to accurately model. We tested the performance of the Biome-BGC model against eddy flux data taken from young (years 2004-2008), mature (years 2002-2008), and old-growth (year 2000) ponderosa pine stands at Metolius, Oregon, and subsequently examined several potential causes for model-data mismatch. We used the Generalized Likelihood Uncertainty Estimation methodology, which involved 500,000 model runs for each stand (1,500,000 total). Each simulation was run with randomly generated parameter values from a uniform distribution based on published parameter ranges, resulting in modeled estimates of net ecosystem CO2 exchange (NEE) that were compared to measured eddy flux data. Simulations for the young stand exhibited the highest level of performance, though they overestimated ecosystem C accumulation (-NEE) 99% of the time. Among the simulations for the mature and old-growth stands, 100% and 99% of the simulations underestimated ecosystem C accumulation. One obvious area of model-data mismatch is soil moisture, which was overestimated by the model in the young and old-growth stands yet underestimated in the mature stand. However, modeled estimates of soil water content and associated water deficits did not appear to be the primary cause of model-data mismatch; our analysis indicated that gross primary production can be accurately modeled even if soil moisture content is not. Instead, difficulties in adequately modeling ecosystem respiration, mainly autotrophic respiration, appeared to be the fundamental cause of model-data mismatch.

Processes influencing model-data mismatch in drought-stressed, fire-disturbed eddy flux sites

NASA Astrophysics Data System (ADS)

Mitchell, S. R.; Beven, K.; Freer, J. E.; Law, B. E.

2010-12-01

Semi-arid forests are very sensitive to climatic change and among the most difficult ecosystems to accurately model. We tested the performance of the Biome-BGC model against eddy flux data taken from young (years 2004-2008), mature (years 2002-2008), and old-growth (year 2000) Ponderosa pine stands at Metolius, Oregon, and subsequently examined several potential causes for model-data mismatch. We used the generalized likelihood uncertainty estimation (GLUE) methodology, which involved 500,000 model runs for each stand (1,500,000 total). Each simulation was run with randomly generated parameter values from a uniform distribution based on published parameter ranges, resulting in modeled estimates of net ecosystem CO2 exchange (NEE) that were compared to measured eddy flux data. Simulations for the young stand exhibited the highest level of performance, though they over-estimated ecosystem C accumulation (-NEE) 99% of the time. Among the simulations for the mature and old-growth stands, 100% and 99% of the simulations under-estimated ecosystem C accumulation. One obvious area of model-data mismatch is soil moisture, which was overestimated by the model in the young and old-growth stands yet underestimated in the mature stand. However, modeled estimates of soil water content and associated water deficits did not appear to be the primary cause of model-data mismatch; our analysis indicated that gross primary production can be accurately modeled even if soil moisture content is not. Instead, difficulties in adequately modeling ecosystem respiration, both autotrophic and heterotrophic, appeared to be fundamental causes of model-data mismatch.

Robot-assisted gait training in multiple sclerosis patients: a randomized trial.

PubMed

Schwartz, Isabella; Sajin, Anna; Moreh, Elior; Fisher, Iris; Neeb, Martin; Forest, Adina; Vaknin-Dembinsky, Adi; Karusis, Dimitrios; Meiner, Zeev

2012-06-01

Preservation of locomotor activity in multiple sclerosis (MS) patients is of utmost importance. Robotic-assisted body weight-supported treadmill training is a promising method to improve gait functions in neurologically impaired patients, although its effectiveness in MS patients is still unknown. To compare the effectiveness of robot-assisted gait training (RAGT) with that of conventional walking treatment (CWT) on gait and generalized functions in a group of stable MS patients. A prospective randomized controlled trial of 12 sessions of RAGT or CWT in MS patients of EDSS score 5-7. Primary outcome measures were gait parameters and the secondary outcomes were functional and quality of life parameters. All tests were performed at baseline, 3 and 6 months post-treatment by a blinded rater. Fifteen and 17 patients were randomly allocated to RAGT and CWT, respectively. Both groups were comparable at baseline in all parameters. As compared with baseline, although some gait parameters improved significantly following the treatment at each time point there was no difference between the groups. Both FIM and EDSS scores improved significantly post-treatment with no difference between the groups. At 6 months, most gait and functional parameters had returned to baseline. Robot-assisted gait training is feasible and safe and may be an effective additional therapeutic option in MS patients with severe walking disabilities.

Cellular signaling identifiability analysis: a case study.

PubMed

Roper, Ryan T; Pia Saccomani, Maria; Vicini, Paolo

2010-05-21

Two primary purposes for mathematical modeling in cell biology are (1) simulation for making predictions of experimental outcomes and (2) parameter estimation for drawing inferences from experimental data about unobserved aspects of biological systems. While the former purpose has become common in the biological sciences, the latter is less common, particularly when studying cellular and subcellular phenomena such as signaling-the focus of the current study. Data are difficult to obtain at this level. Therefore, even models of only modest complexity can contain parameters for which the available data are insufficient for estimation. In the present study, we use a set of published cellular signaling models to address issues related to global parameter identifiability. That is, we address the following question: assuming known time courses for some model variables, which parameters is it theoretically impossible to estimate, even with continuous, noise-free data? Following an introduction to this problem and its relevance, we perform a full identifiability analysis on a set of cellular signaling models using DAISY (Differential Algebra for the Identifiability of SYstems). We use our analysis to bring to light important issues related to parameter identifiability in ordinary differential equation (ODE) models. We contend that this is, as of yet, an under-appreciated issue in biological modeling and, more particularly, cell biology. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

Evaluation of a novel algorithm for primary mass casualty triage by paramedics in a physician manned EMS system: a dummy based trial

PubMed Central

2014-01-01

Background The Amberg-Schwandorf Algorithm for Primary Triage (ASAV) is a novel primary triage concept specifically for physician manned emergency medical services (EMS) systems. In this study, we determined the diagnostic reliability and the time requirements of ASAV triage. Methods Seven hundred eighty triage runs performed by 76 trained EMS providers of varying professional qualification were included into the study. Patients were simulated using human dummies with written vital signs sheets. Triage results were compared to a standard solution, which was developed in a modified Delphi procedure. Test performance parameters (e.g. sensitivity, specificity, likelihood ratios (LR), under-triage, and over-triage) were calculated. Time measurements comprised the complete triage and tagging process and included the time span for walking to the subsequent patient. Results were compared to those published for mSTaRT. Additionally, a subgroup analysis was performed for employment status (career/volunteer), team qualification, and previous triage training. Results For red patients, ASAV sensitivity was 87%, specificity 91%, positive LR 9.7, negative LR 0.139, over-triage 6%, and under-triage 10%. There were no significant differences related to mSTaRT. Per patient, ASAV triage required a mean of 35.4 sec (75th percentile 46 sec, 90th percentile 58 sec). Volunteers needed slightly more time to perform triage than EMS professionals. Previous mSTaRT training of the provider reduced under-triage significantly. There were significant differences in time requirements for triage depending on the expected triage category. Conclusions The ASAV is a specific concept for primary triage in physician governed EMS systems. It may detect red patients reliably. The test performance criteria are comparable to that of mSTaRT, whereas ASAV triage might be accomplished slightly faster. From the data, there was no evidence for a clinically significant reliability difference between typical staffing of mobile intensive care units, patient transport ambulances, or disaster response volunteers. Up to now, there is no clinical validation of either triage concept. Therefore, reality based evaluation studies are needed. PMID:25214310

Comparison of flying qualities derived from in-flight and ground-based simulators for a jet-transport airplane for the approach and landing pilot tasks

NASA Technical Reports Server (NTRS)

Grantham, William D.

1989-01-01

The primary objective was to provide information to the flight controls/flying qualities engineer that will assist him in determining the incremental flying qualities and/or pilot-performance differences that may be expected between results obtained via ground-based simulation (and, in particular, the six-degree-of-freedom Langley Visual/Motion Simulator (VMS)) and flight tests. Pilot opinion and performance parameters derived from a ground-based simulator and an in-flight simulator are compared for a jet-transport airplane having 32 different longitudinal dynamic response characteristics. The primary pilot tasks were the approach and landing tasks with emphasis on the landing-flare task. The results indicate that, in general, flying qualities results obtained from the ground-based simulator may be considered conservative-especially when the pilot task requires tight pilot control as during the landing flare. The one exception to this, according to the present study, was that the pilots were more tolerant of large time delays in the airplane response on the ground-based simulator. The results also indicated that the ground-based simulator (particularly the Langley VMS) is not adequate for assessing pilot/vehicle performance capabilities (i.e., the sink rate performance for the landing-flare task when the pilot has little depth/height perception from the outside scene presentation).

SU-E-T-439: An Improved Formula of Scatter-To-Primary Ratio for Photon Dose Calculation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhu, T

2014-06-01

Purpose: Scatter-to-primary ratio (SPR) is an important dosimetric quantity that describes the contribution from the scatter photons in an external photon beam. The purpose of this study is to develop an improved analytical formula to describe SPR as a function of circular field size (r) and depth (d) using Monte Carlo (MC) simulation. Methods: MC simulation was performed for Mohan photon spectra (Co-60, 4, 6, 10, 15, 23 MV) using EGSNRC code. Point-spread scatter dose kernels in water are generated. The scatter-to-primary ratio (SPR) is also calculated using MC simulation as a function of field size for circular field sizemore » with radius r and depth d. The doses from forward scatter and backscatter photons are calculated using a convolution of the point-spread scatter dose kernel and by accounting for scatter photons contributing to dose before (z'd) reaching the depth of interest, d, where z' is the location of scatter photons, respectively. The depth dependence of the ratio of the forward scatter and backscatter doses is determined as a function of depth and field size. Results: We are able to improve the existing 3-parameter (a, w, d0) empirical formula for SPR by introducing depth dependence for one of the parameter d0, which becomes 0 for deeper depths. The depth dependence of d0 can be directly calculated as a ratio of backscatter-to-forward scatter doses for otherwise the same field and depth. With the improved empirical formula, we can fit SPR for all megavoltage photon beams to within 2%. Existing 3-parameter formula cannot fit SPR data for Co-60 to better than 3.1%. Conclusion: An improved empirical formula is developed to fit SPR for all megavoltage photon energies to within 2%.« less

Improving the Fit of a Land-Surface Model to Data Using its Adjoint

NASA Astrophysics Data System (ADS)

Raoult, Nina; Jupp, Tim; Cox, Peter; Luke, Catherine

2016-04-01

Land-surface models (LSMs) are crucial components of the Earth System Models (ESMs) which are used to make coupled climate-carbon cycle projections for the 21st century. The Joint UK Land Environment Simulator (JULES) is the land-surface model used in the climate and weather forecast models of the UK Met Office. In this study, JULES is automatically differentiated using commercial software from FastOpt, resulting in an analytical gradient, or adjoint, of the model. Using this adjoint, the adJULES parameter estimation system has been developed, to search for locally optimum parameter sets by calibrating against observations. We present an introduction to the adJULES system and demonstrate its ability to improve the model-data fit using eddy covariance measurements of gross primary production (GPP) and latent heat (LE) fluxes. adJULES also has the ability to calibrate over multiple sites simultaneously. This feature is used to define new optimised parameter values for the 5 Plant Functional Types (PFTS) in JULES. The optimised PFT-specific parameters improve the performance of JULES over 90% of the FLUXNET sites used in the study. These reductions in error are shown and compared to reductions found due to site-specific optimisations. Finally, we show that calculation of the 2nd derivative of JULES allows us to produce posterior probability density functions of the parameters and how knowledge of parameter values is constrained by observations.

An efficient recursive least square-based condition monitoring approach for a rail vehicle suspension system

NASA Astrophysics Data System (ADS)

Liu, X. Y.; Alfi, S.; Bruni, S.

2016-06-01

A model-based condition monitoring strategy for the railway vehicle suspension is proposed in this paper. This approach is based on recursive least square (RLS) algorithm focusing on the deterministic 'input-output' model. RLS has Kalman filtering feature and is able to identify the unknown parameters from a noisy dynamic system by memorising the correlation properties of variables. The identification of suspension parameter is achieved by machine learning of the relationship between excitation and response in a vehicle dynamic system. A fault detection method for the vertical primary suspension is illustrated as an instance of this condition monitoring scheme. Simulation results from the rail vehicle dynamics software 'ADTreS' are utilised as 'virtual measurements' considering a trailer car of Italian ETR500 high-speed train. The field test data from an E464 locomotive are also employed to validate the feasibility of this strategy for the real application. Results of the parameter identification performed indicate that estimated suspension parameters are consistent or approximate with the reference values. These results provide the supporting evidence that this fault diagnosis technique is capable of paving the way for the future vehicle condition monitoring system.

A Particle and Energy Balance Model of the Orificed Hollow Cathode

NASA Technical Reports Server (NTRS)

Domonkos, Matthew T.

2002-01-01

A particle and energy balance model of orificed hollow cathodes was developed to assist in cathode design. The model presented here is an ensemble of original work by the author and previous work by others. The processes in the orifice region are considered to be one of the primary drivers in determining cathode performance, since the current density was greatest in this volume (up to 1.6 x 10(exp 8) A/m2). The orifice model contains comparatively few free parameters, and its results are used to bound the free parameters for the insert model. Next, the insert region model is presented. The sensitivity of the results to the free parameters is assessed, and variation of the free parameters in the orifice dominates the calculated power consumption and plasma properties. The model predictions are compared to data from a low-current orificed hollow cathode. The predicted power consumption exceeds the experimental results. Estimates of the plasma properties in the insert region overlap Langmuir probe data, and the predicted orifice plasma suggests the presence of one or more double layers. Finally, the model is used to examine the operation of higher current cathodes.

Estimating parameters of hidden Markov models based on marked individuals: use of robust design data

USGS Publications Warehouse

Kendall, William L.; White, Gary C.; Hines, James E.; Langtimm, Catherine A.; Yoshizaki, Jun

2012-01-01

Development and use of multistate mark-recapture models, which provide estimates of parameters of Markov processes in the face of imperfect detection, have become common over the last twenty years. Recently, estimating parameters of hidden Markov models, where the state of an individual can be uncertain even when it is detected, has received attention. Previous work has shown that ignoring state uncertainty biases estimates of survival and state transition probabilities, thereby reducing the power to detect effects. Efforts to adjust for state uncertainty have included special cases and a general framework for a single sample per period of interest. We provide a flexible framework for adjusting for state uncertainty in multistate models, while utilizing multiple sampling occasions per period of interest to increase precision and remove parameter redundancy. These models also produce direct estimates of state structure for each primary period, even for the case where there is just one sampling occasion. We apply our model to expected value data, and to data from a study of Florida manatees, to provide examples of the improvement in precision due to secondary capture occasions. We also provide user-friendly software to implement these models. This general framework could also be used by practitioners to consider constrained models of particular interest, or model the relationship between within-primary period parameters (e.g., state structure) and between-primary period parameters (e.g., state transition probabilities).

Optimized estimation and its uncertainties of gross primary production over oasis-desert ecosystems in an arid region of China

NASA Astrophysics Data System (ADS)

Wang, H.; Li, X.; Xiao, J.; Ma, M.

2017-12-01

Arid and semi-arid ecosystems cover more than one-third of the Earth's land surface, it is of great important to the global carbon cycle. However, the magnitude of carbon sequestration and its contribution to global atmospheric carbon cycle is poorly understood due to the worldwide paucity of measurements of carbon exchange in the arid ecosystems. Accurate and continuous monitoring the production of arid ecosystem is of great importance for regional carbon cycle estimation. The MOD17A2 product provides high frequency observations of terrestrial Gross Primary Productivity (GPP) over the world. Although there have been plenty of studies to validate the MODIS GPP products with ground based measurements over a range of biome types, few have comprehensively validated the performance of MODIS estimates in arid and semi-arid ecosystems. Thus, this study examined the performance of the MODIS-derived GPP comparing with the EC observed GPP at different timescales for the main arid ecosystems in the arid and semi-arid ecosystems in China, and optimized the performance of the MODIS GPP calculations by using the in-situ metrological forcing data, and optimization of biome-specific parameters with the Bayesian approach. Our result revealed that the MOD17 algorithm could capture the broad trends of GPP at 8-day time scales for all investigated sites on the whole. However, the GPP product was underestimated in most ecosystems in the arid region, especially the irrigated cropland and forest ecosystems, while the desert ecosystem was overestimated in the arid region. On the annual time scale, the best performance was observed in grassland and cropland, followed by forest and desert ecosystems. On the 8-day timescale, the RMSE between MOD17 products and in-situ flux observations of all sites was 2.22 gC/m2/d, and R2 was 0.69. By using the in-situ metrological data driven, optimizing the biome-based parameters of the algorithm, we improved the performances of the MODIS GPP calculation over the main ecosystems in arid region of China.

Abnormal externally guided movement preparation in recent-onset schizophrenia is associated with impaired selective attention to external input.

PubMed

Smid, Henderikus G O M; Westenbroek, Joanna M; Bruggeman, Richard; Knegtering, Henderikus; Van den Bosch, Robert J

2009-11-30

Several theories propose that the primary cognitive impairment in schizophrenia concerns a deficit in the processing of external input information. There is also evidence, however, for impaired motor preparation in schizophrenia. This provokes the question whether the impaired motor preparation in schizophrenia is a secondary consequence of disturbed (selective) processing of the input needed for that preparation, or an independent primary deficit. The aim of the present study was to discriminate between these hypotheses, by investigating externally guided movement preparation in relation to selective stimulus processing. The sample comprised 16 recent-onset schizophrenia patients and 16 controls who performed a movement-precuing task. In this task, a precue delivered information about one, two or no parameters of a movement summoned by a subsequent stimulus. Performance measures and measures derived from the electroencephalogram showed that patients yielded smaller benefits from the precues and showed less cue-based preparatory activity in advance of the imperative stimulus than the controls, suggesting a response preparation deficit. However, patients also showed less activity reflecting selective attention to the precue. We therefore conclude that the existing evidence for an impairment of externally guided motor preparation in schizophrenia is most likely due to a deficit in selective attention to the external input, which lends support to theories proposing that the primary cognitive deficit in schizophrenia concerns the processing of input information.

Environmental analysis of a construction and demolition waste recycling plant in Portugal--Part II: Environmental sensitivity analysis.

PubMed

Coelho, André; de Brito, Jorge

2013-01-01

Part I of this study deals with the primary energy consumption and CO(2)eq emissions of a 350 tonnes/h construction and demolition waste (CDW) recycling facility, taking into account incorporated, operation and transportation impacts. It concludes that the generated impacts are mostly concentrated in operation and transportation, and that the impacts prevented through material recycling can be up to one order of magnitude greater than those generated. However, the conditions considered for the plant's operation and related transportation system may, and very likely will, vary in the near future, which will affect its environmental performance. This performance is particularly affected by the plant's installed capacity, transportation fuel and input CDW mass. In spite of the variations in overall primary energy and CO(2)eq balances, the prevented impacts are always higher than the generated impacts, at least by a factor of three and maybe even as high as 16 times in particular conditions. The analysis indicates environmental performance for variations in single parameters, except for the plant's capacity, which was considered to vary simultaneously with all the others. Extreme best and worst scenarios were also generated to fit the results into extreme limits. Copyright © 2012 Elsevier Ltd. All rights reserved.

Pretreatment of a primary and secondary sludge blend at different thermal hydrolysis temperatures: Impacts on anaerobic digestion, dewatering and filtrate characteristics.

PubMed

Higgins, Matthew J; Beightol, Steven; Mandahar, Ushma; Suzuki, Ryu; Xiao, Steven; Lu, Hung-Wei; Le, Trung; Mah, Joshua; Pathak, Bipin; DeClippeleir, Haydee; Novak, John T; Al-Omari, Ahmed; Murthy, Sudhir N

2017-10-01

A study was performed to evaluate the effect of thermal hydrolysis pretreatment (THP) temperature on subsequent digestion performance and operation, as well as downstream parameters such as dewatering and cake quality. A blend of primary and secondary solids from the Blue Plains treatment plant in Washington, DC was dewatered to about 16% total solids (TS), and thermally hydrolyzed at five different temperatures 130, 140, 150, 160, 170 °C. The thermally hydrolyzed solids were then fed to five separate, 10 L laboratory digesters using the same feed concentration, 10.5% TS and a solids retention time (SRT) of 15 days. The digesters were operated over a six month period to achieve steady state conditions. The higher thermal hydrolysis temperatures generally improved the solids reduction and methane yields by about 5-6% over the temperature range. The increased temperature reduced viscosity of the solids and increased the cake solids after dewatering. The dissolved organic nitrogen and UV absorbance generally increased at the higher THP temperatures. Overall, operating at a higher temperature improved performance with a tradeoff of higher dissolved organic nitrogen and UV adsorbing materials in the return liquor. Copyright © 2017 Elsevier Ltd. All rights reserved.

Updating national standards for drinking-water: a Philippine experience.

PubMed

Lomboy, M; Riego de Dios, J; Magtibay, B; Quizon, R; Molina, V; Fadrilan-Camacho, V; See, J; Enoveso, A; Barbosa, L; Agravante, A

2017-04-01

The latest version of the Philippine National Standards for Drinking-Water (PNSDW) was issued in 2007 by the Department of Health (DOH). Due to several issues and concerns, the DOH decided to make an update which is relevant and necessary to meet the needs of the stakeholders. As an output, the water quality parameters are now categorized into mandatory, primary, and secondary. The ten mandatory parameters are core parameters which all water service providers nationwide are obligated to test. These include thermotolerant coliforms or Escherichia coli, arsenic, cadmium, lead, nitrate, color, turbidity, pH, total dissolved solids, and disinfectant residual. The 55 primary parameters are site-specific and can be adopted as enforceable parameters when developing new water sources or when the existing source is at high risk of contamination. The 11 secondary parameters include operational parameters and those that affect the esthetic quality of drinking-water. In addition, the updated PNSDW include new sections: (1) reporting and interpretation of results and corrective actions; (2) emergency drinking-water parameters; (3) proposed Sustainable Development Goal parameters; and (4) standards for other drinking-water sources. The lessons learned and insights gained from the updating of standards are likewise incorporated in this paper.

The impact of prism adaptation test on surgical outcomes in patients with primary exotropia.

PubMed

Kiyak Yilmaz, Ayse; Kose, Suheyla; Guven Yilmaz, Suzan; Uretmen, Onder

2015-05-01

We aimed to determine the impact of the preoperative prism adaptation test (PAT) on surgical outcomes in patients with primary exotropia. Thirty-eight consecutive patients with primary exotropia were enrolled. Pre-operative PAT was performed in 18 randomly selected patients (Group 1). Surgery was based on the angle of deviation at distance measured after PAT. The remaining 20 patients in whom PAT was not performed comprised Group 2. Surgery was based on the angle of deviation at distance in these patients. Surgical success was defined as ocular alignment within eight prism dioptres (PD) of orthophoria. Satisfactory motor alignment (± 8 PD) was achieved in 16 Group 1 patients (88.9 per cent) and 16 Group 2 patients (80 per cent) one year after surgery (p = 0.6; chi-square test). There were no statistically significant differences in demographic parameters, pre-operative and post-operative angle of deviation between the two groups (p > 0.05; Mann-Whitney U and chi-square tests). Nine patients in Group 1 (50 per cent) and two patients in Group 2 (10 per cent) had increased binocular vision one year post-operatively. A statistically significant difference was determined in terms of change in binocular single vision between the two groups (p = 0.01; chi-square test). Although the prism adaptation test did not lead to a significant increment in motor success, it may be helpful in achieving a more favourable functional surgical outcome in patients with primary exotropia. © 2014 The Authors. Clinical and Experimental Optometry © 2014 Optometrists Association Australia.

Symptom clusters in advanced cancer.

PubMed

Jiménez, Ana; Madero, Rosario; Alonso, Alberto; Martínez-Marín, Virginia; Vilches, Yolanda; Martínez, Beatriz; Feliu, Marta; Díaz, Leyre; Espinosa, Enrique; Feliu, Jaime

2011-07-01

Patients with advanced cancer often experience multiple concurrent symptoms. Few studies have explored symptom clusters (SCs) in this population. The aim of the present study was to explore SCs in advanced cancer, evaluate the characteristics associated with various clusters, and determine their relationship to survival. This study included patients in the palliative care program of the Hospital Universitario La Paz from 2003 to 2005. The Edmonton Symptom Assessment System and a supplement including 13 other symptoms were used to detect symptoms. Principal component analysis was performed to determine symptom relationships and compare SCs with associated parameters. In total, 406 patients were included, 61% men and 39% women. The median age was 66.4 (range 18-95). The most common primaries were gastrointestinal (35%), lung (25%), genitourinary (8%), breast (5%), and head and neck (5%) carcinomas. The following clusters were identified: confusion (cognitive impairment, agitation, urinary incontinence), neuropsychological (anxiety, depression, and insomnia), anorexia-cachexia (anorexia, weight loss, and tiredness), and gastrointestinal (nausea and vomiting). The presence of these SCs was influenced by primary cancer site, gender, age, and performance status. Survival was related to the number of SCs present in a given patient: zero SC, 52 days; one SC, 38 days; two SCs, 23 days; and three to four SCs, 19 days; P < 0.001. Different SCs can be identified in patients with advanced cancer. These SCs are influenced by primary cancer site, gender, age, and Eastern Cooperative Oncology Group performance status, and they can have prognostic value. Copyright © 2011 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved.

The productivity and cost-efficiency of models for involving nurse practitioners in primary care: a perspective from queueing analysis.

PubMed

Liu, Nan; D'Aunno, Thomas

2012-04-01

To develop simple stylized models for evaluating the productivity and cost-efficiencies of different practice models to involve nurse practitioners (NPs) in primary care, and in particular to generate insights on what affects the performance of these models and how. The productivity of a practice model is defined as the maximum number of patients that can be accounted for by the model under a given timeliness-to-care requirement; cost-efficiency is measured by the corresponding annual cost per patient in that model. Appropriate queueing analysis is conducted to generate formulas and values for these two performance measures. Model parameters for the analysis are extracted from the previous literature and survey reports. Sensitivity analysis is conducted to investigate the model performance under different scenarios and to verify the robustness of findings. Employing an NP, whose salary is usually lower than a primary care physician, may not be cost-efficient, in particular when the NP's capacity is underutilized. Besides provider service rates, workload allocation among providers is one of the most important determinants for the cost-efficiency of a practice model involving NPs. Capacity pooling among providers could be a helpful strategy to improve efficiency in care delivery. The productivity and cost-efficiency of a practice model depend heavily on how providers organize their work and a variety of other factors related to the practice environment. Queueing theory provides useful tools to take into account these factors in making strategic decisions on staffing and panel size selection for a practice model. © Health Research and Educational Trust.

Performance of Solar Electric Powered Deep Space Missions Using Hall Thruster Propulsion

NASA Technical Reports Server (NTRS)

Witzberger, Kevin E.; Manzella, David

2006-01-01

Power limited, low-thrust trajectories were assessed for missions to Jupiter, Saturn, and Neptune utilizing a single Venus Gravity Assist (VGA) and a primary propulsion system based on either a 3-kW high voltage Hall thruster, of the type being developed by the NASA In-Space Propulsion Technology Program, or an 8-kW variant of this thruster. These Hall thrusters operate with specific impulses below 3,000 seconds. A trade study was conducted to examine mission parameters that include: net delivered mass (NDM), beginning-of-life (BOL) solar array power, heliocentric transfer time, required launch vehicle, number of operating thrusters, and throttle profile. The top performing spacecraft configuration was defined to be the one that delivered the highest mass for a range of transfer times. In order to evaluate the potential future benefit of using next generation Hall thrusters as the primary propulsion system, comparisons were made with the advanced state-of-the-art (ASOA), 7-kW, 4,100 second NASA's Evolutionary Xenon Thruster (NEXT) for the same mission scenarios. For the BOL array powers considered in this study (less than 30 kW), the results show that the performance of the Hall thrusters, relative to NEXT, is largely dependant on the performance capability of the launch vehicle, and that at least a 10 percent performance gain, equating to at least an additional 200 kg dry mass at each target planet, is achieved over the higher specific impulse NEXT when launched on an Atlas 551.

Positive effects of Red Bull® Energy Drink on driving performance during prolonged driving.

PubMed

Mets, Monique A J; Ketzer, Sander; Blom, Camilla; van Gerven, Maartje H; van Willigenburg, Gitta M; Olivier, Berend; Verster, Joris C

2011-04-01

The purpose of this study was to examine if Red Bull® Energy Drink can counteract sleepiness and driving impairment during prolonged driving. Twenty-four healthy volunteers participated in this double-blind placebo-controlled crossover study. After 2 h of highway driving in the STISIM driving simulator, subjects had a 15-min break and consumed Red Bull® Energy Drink (250 ml) or placebo (Red Bull® Energy Drink without the functional ingredients: caffeine, taurine, glucuronolactone, B vitamins (niacin, pantothenic acid, B6, B12), and inositol) before driving for two additional hours. A third condition comprised 4 h of uninterrupted driving. Primary parameter was the standard deviation of lateral position (SDLP), i.e., the weaving of the car. Secondary parameters included SD speed, subjective driving quality, sleepiness, and mental effort to perform the test. No significant differences were observed during the first 2 h of driving. Red Bull® Energy Drink significantly improved driving relative to placebo: SDLP was significantly reduced during the 3rd (p < 0.046) and 4th hour of driving (p < 0.011). Red Bull® Energy Drink significantly reduced the standard deviation of speed (p < 0.004), improved subjective driving quality (p < 0.0001), and reduced mental effort to perform the test (p < 0.024) during the 3rd hour of driving. Subjective sleepiness was significantly decreased during both the 3rd and 4th hour of driving after Red Bull® Energy Drink (p < 0.001 and p < 0.009, respectively). Relative to uninterrupted driving, Red Bull® Energy Drink significantly improved each parameter. Red Bull® Energy Drink significantly improves driving performance and reduces driver sleepiness during prolonged highway driving.

Effects of shape and stroke parameters on the propulsion performance of an axisymmetric swimmer.

PubMed

Peng, Jifeng; Alben, Silas

2012-03-01

In nature, there exists a special group of aquatic animals which have an axisymmetric body and whose primary swimming mechanism is to use periodic body contractions to generate vortex rings in the surrounding fluid. Using jellyfish medusae as an example, this study develops a mathematical model of body kinematics of an axisymmetric swimmer and uses a computational approach to investigate the induced vortex wakes. Wake characteristics are identified for swimmers using jet propulsion and rowing, two mechanisms identified in previous studies of medusan propulsion. The parameter space of body kinematics is explored through four quantities: a measure of body shape, stroke amplitude, the ratio between body contraction duration and extension duration, and the pulsing frequency. The effects of these parameters on thrust, input power requirement and circulation production are quantified. Two metrics, cruising speed and energy cost of locomotion, are used to evaluate the propulsion performance. The study finds that a more prolate-shaped swimmer with larger stroke amplitudes is able to swim faster, but its cost of locomotion is also higher. In contrast, a more oblate-shaped swimmer with smaller stroke amplitudes uses less energy for its locomotion, but swims more slowly. Compared with symmetric strokes with equal durations of contraction and extension, faster bell contractions increase the swimming speed whereas faster bell extensions decrease it, but both require a larger energy input. This study shows that besides the well-studied correlations between medusan body shape and locomotion, stroke variables also affect the propulsion performance. It provides a framework for comparing the propulsion performance of axisymmetric swimmers based on their body kinematics when it is difficult to measure and analyze their wakes empirically. The knowledge from this study is also useful for the design of robotic swimmers that use axisymmetric body contractions for propulsion.

The Development of a Microbial Challenge Test with Acholeplasma laidlawii To Rate Mycoplasma-Retentive Filters by Filter Manufacturers.

PubMed

Folmsbee, Martha; Lentine, Kerry Roche; Wright, Christine; Haake, Gerhard; Mcburnie, Leesa; Ashtekar, Dilip; Beck, Brian; Hutchison, Nick; Okhio-Seaman, Laura; Potts, Barbara; Pawar, Vinayak; Windsor, Helena

2014-01-01

Mycoplasma are bacteria that can penetrate 0.2 and 0.22 μm rated sterilizing-grade filters and even some 0.1 μm rated filters. Primary applications for mycoplasma filtration include large scale mammalian and bacterial cell culture media and serum filtration. The Parenteral Drug Association recognized the absence of standard industry test parameters for testing and classifying 0.1 μm rated filters for mycoplasma clearance and formed a task force to formulate consensus test parameters. The task force established some test parameters by common agreement, based upon general industry practices, without the need for additional testing. However, the culture medium and incubation conditions, for generating test mycoplasma cells, varied from filter company to filter company and was recognized as a serious gap by the task force. Standardization of the culture medium and incubation conditions required collaborative testing in both commercial filter company laboratories and in an Independent laboratory (Table I). The use of consensus test parameters will facilitate the ultimate cross-industry goal of standardization of 0.1 μm filter claims for mycoplasma clearance. However, it is still important to recognize filter performance will depend on the actual conditions of use. Therefore end users should consider, using a risk-based approach, whether process-specific evaluation of filter performance may be warranted for their application. Mycoplasma are small bacteria that have the ability to penetrate sterilizing-grade filters. Filtration of large-scale mammalian and bacterial cell culture media is an example of an industry process where effective filtration of mycoplasma is required. The Parenteral Drug Association recognized the absence of industry standard test parameters for evaluating mycoplasma clearance filters by filter manufacturers and formed a task force to formulate such a consensus among manufacturers. The use of standardized test parameters by filter manufacturers, including the preparation of the culture broth, will facilitate the end user's evaluation of the mycoplasma clearance claims provided by filter vendors. However, it is still important to recognize filter performance will depend on the actual conditions of use; therefore end users should consider, using a risk-based approach, whether process-specific evaluation of filter performance may be warranted for their application. © PDA, Inc. 2014.

Autoignition response of n-butanol and its blend with primary reference fuel constituents of gasoline.

DOE PAGES

Kumar, Kamal; Zhang, Yu; Sung, Chi -Jen; ...

2015-04-13

We study the influence of blending n-butanol on the ignition delay times of n-heptane and iso-octane, the primary reference fuels for gasoline. The ignition delay times are measured using a rapid compression machine, with an emphasis on the low-to-intermediate temperature conditions. The experiments are conducted at equivalence ratios of 0.4 and 1.0, for a compressed pressure of 20 bar, with the temperatures at the end of compression ranging from 613 K to 979 K. The effect of n-butanol addition on the development of the two-stage ignition characteristics for the two primary reference fuels is also examined. The experimental results aremore » compared to predictions obtained using a detailed chemical kinetic mechanism, which has been obtained by a systematic merger of previously reported base models for the combustion of the individual fuel constituents. In conclusion, a sensitivity analysis on the base, and the merged models, is also performed to understand the dependence of autoignition delay times on the model parameters.« less

Trust and Reflection in Primary Care Practice Redesign.

PubMed

Lanham, Holly Jordan; Palmer, Raymond F; Leykum, Luci K; McDaniel, Reuben R; Nutting, Paul A; Stange, Kurt C; Crabtree, Benjamin F; Miller, William L; Jaén, Carlos Roberto

2016-08-01

To test a conceptual model of relationships, reflection, sensemaking, and learning in primary care practices transitioning to patient-centered medical homes (PCMH). Primary data were collected as part of the American Academy of Family Physicians' National Demonstration Project of the PCMH. We conducted a cross-sectional survey of clinicians and staff from 36 family medicine practices across the United States. Surveys measured seven characteristics of practice relationships (trust, diversity, mindfulness, heedful interrelation, respectful interaction, social/task relatedness, and rich and lean communication) and three organizational attributes (reflection, sensemaking, and learning) of practices. We surveyed 396 clinicians and practice staff. We performed a multigroup path analysis of the data. Parameter estimates were calculated using a Bayesian estimation method. Trust and reflection were important in explaining the characteristics of practice relationships and their associations with sensemaking and learning. The strongest associations between relationships, sensemaking, and learning were found under conditions of high trust and reflection. The weakest associations were found under conditions of low trust and reflection. Trust and reflection appear to play a key role in moderating relationships, sensemaking, and learning in practices undergoing practice redesign. © Health Research and Educational Trust.

Influence of movement parameters on area 18 neurones in the cat.

PubMed

Orban, G A; Callens, M

1977-10-24

In cats, 107 area 18 neurones with identified FR type, 10-50 degrees from the visual axis, were tested for the influence of direction, velocity and amplitude of movement. These three parameters are believed to be the primary parameters of a movement analysing system. 94% of the neurones were influenced by the direction of movement, all of them by the angular velocity and 16% by the amplitude of movement. For each of the primary parameters, tuning curves were established. Angular velocity influenced not only the response magnitude but also the response latency and the direction bias. By preparing response amplitude functions at different velocities the influence of movement duration was ruled out. The association of functional properties and RF organization suggests a model of information processing in area 18 of the cat.

Effects of stimulation parameters and electrode location on thresholds for epidural stimulation of cat motor cortex

NASA Astrophysics Data System (ADS)

Wongsarnpigoon, Amorn; Grill, Warren M.

2011-12-01

Epidural electrical stimulation (ECS) of the motor cortex is a developing therapy for neurological disorders. Both placement and programming of ECS systems may affect the therapeutic outcome, but the treatment parameters that will maximize therapeutic outcomes and minimize side effects are not known. We delivered ECS to the motor cortex of anesthetized cats and investigated the effects of electrode placement and stimulation parameters on thresholds for evoking motor responses in the contralateral forelimb. Thresholds were inversely related to stimulation frequency and the number of pulses per stimulus train. Thresholds were lower over the forelimb representation in motor cortex (primary site) than surrounding sites (secondary sites), and thresholds at sites <4 mm away from the primary site were significantly lower than at sites >4 mm away. Electrode location and montage influenced the effects of polarity on thresholds: monopolar anodic and cathodic thresholds were not significantly different over the primary site, cathodic thresholds were significantly lower than anodic thresholds over secondary sites and bipolar thresholds were significantly lower with the anode over the primary site than with the cathode over the primary site. A majority of bipolar thresholds were either between or equal to the respective monopolar thresholds, but several bipolar thresholds were greater than or less than the monopolar thresholds of both the anode and cathode. During bipolar stimulation, thresholds were influenced by both electric field superposition and indirect, synaptically mediated interactions. These results demonstrate the influence of stimulation parameters and electrode location during cortical stimulation, and these effects should be considered during the programming of systems for therapeutic cortical stimulation.

Pirfenidone for the treatment of Hermansky-Pudlak Syndrome pulmonary fibrosis

PubMed Central

O’Brien, Kevin; Troendle, James; Gochuico, Bernadette R.; Markello, Thomas C.; Salas, Jose; Cardona, Hilda; Yao, Jianhua; Bernardini, Isa; Hess, Richard; Gahl, William A.

2013-01-01

Hermansky-Pudlak syndrome (HPS) type is a rare disorder of oculocutaneous albinism, platelet dysfunction, and in some subtypes, fatal pulmonary fibrosis. There is no effective treatment for the pulmonary fibrosis except lung transplantation, but an initial trial using pirfenidone, an anti-fibrotic agent, showed promising results. The current, randomized, placebo-controlled, prospective, double-blind trial investigated the safety and efficacy of pirfenidone for mild to moderate HPS-1 and 4 pulmonary fibrosis. Subjects were evaluated every 4 months at the National Institutes of Health Clinical Center, and the primary outcome parameter was change in forced vital capacity using repeated measures analysis with random coefficients. Thirty-five subjects with HPS-1 pulmonary fibrosis were enrolled during a 4-year interval; 23 subjects received pirfenidone and 12 received placebo. Four subjects withdrew from the trial, 3 subjects died, and 10 serious adverse events were reported. Both groups experienced similar side effects, especially gastroesophageal reflux. Interim analysis of the primary outcome parameter, performed 12 months after 30 patients were enrolled, showed no statistical difference between the placebo and pirfenidone groups, and the study was stopped due to futility. There were no significant safety concerns. Other clinical trials are indicated to identify single or multiple drug regimens that may be effective in treatment for progressive HPS-1 pulmonary fibrosis. PMID:21420888

Relationship between blood pressure and retrobulbar blood flow in dipper and nondipper primary open-angle glaucoma patients.

PubMed

Marjanović, Ivan; Marjanović, Marija; Martinez, Antonio; Marković, Vujica; Božić, Marija; Stojanov, Vesna

2016-11-04

To evaluate the relationship between retrobulbar hemodynamic parameters in the ophthalmic artery (OA), central retinal artery, and short posterior ciliary artery and 24-hour blood pressure (BP) measurements in dipper and nondipper patients with primary open-angle glaucoma (POAG). A prospective, cross-sectional, and observational study was conducted on consecutive patients, referred or recruited, attending the outpatient service of our ophthalmology department. Ambulatory BP monitoring, Doppler imaging, and ocular pulse amplitude measurements were performed on the same day. Patients with nocturnal BP decrease up to 10% of the diurnal BP were defined as dippers and those with BP decrease less than 10% were defined as nondippers. A total of 114 patients (36 nondippers and 78 dippers) were included in the study. The end-diastolic velocity was significantly lower and the resistivity index (RI) was significantly higher in the dippers than in the nondippers (p<0.0001 and p<0.0001, respectively). The RI in the OA was significantly correlated with daytime and nighttime systolic BP and with the daytime mean arterial pressure in the dippers. The RI in the OA significantly correlates with BP in patients with POAG with nocturnal BP dips. Additionally, retrobulbar blood flow parameters are reduced in dippers as compared with nondippers with POAG.

Impact of Inflow Conditions on Coherent Structures in an Aneurysm

NASA Astrophysics Data System (ADS)

Yu, Paulo; Durgesh, Vibhav; Johari, Hamid

2017-11-01

An aneurysm is an enlargement of a weakened arterial wall that can be debilitating or fatal on rupture. Studies have shown that hemodynamics is integral to developing an understanding of aneurysm formation, growth, and rupture. This investigation focuses on a comprehensive study of the impact of varying inflow conditions and aneurysm shapes on spatial and temporal behavior of flow parameters and structures in an aneurysm. Two different shapes of an idealized rigid aneurysm model were studied and the non-dimensional frequency and Reynolds number were varied between 2-5 and 50-250, respectively. A ViVitro Labs SuperPump system was used to precisely control inflow conditions. Particle Image Velocimetry (PIV) measurements were performed at three different locations inside the aneurysm sac to obtain detailed velocity flow field information. The results of this study showed that aneurysm morphology significantly impacts spatial and temporal behavior of large-scale flow structures as well as wall shear stress distribution. The flow behavior and structures showed a significant difference with change in inflow conditions. A primary fluctuating flow structure was observed for Reynolds number of 50, while for higher Reynolds numbers, primary and secondary flow structures were observed. Furthermore, the paths of these coherent structures were dependent on aneurysm shape and inflow parameters.

Theoretical performance analysis of doped optical fibers based on pseudo parameters

NASA Astrophysics Data System (ADS)

Karimi, Maryam; Seraji, Faramarz E.

2010-09-01

Characterization of doped optical fibers (DOFs) is an essential primary stage for design of DOF-based devices. This paper presents design of novel measurement techniques to determine DOFs parameters using mono-beam propagation in a low-loss medium by generating pseudo parameters for the DOFs. The designed techniques are able to characterize simultaneously the absorption, emission cross-sections (ACS and ECS), and dopant concentration of DOFs. In both the proposed techniques, we assume pseudo parameters for the DOFs instead of their actual values and show that the choice of these pseudo parameters values for design of DOF-based devices, such as erbium-doped fiber amplifier (EDFA), are appropriate and the resulting error is quite negligible when compared with the actual parameters values.Utilization of pseudo ACS and ECS values in design procedure of EDFAs does not require the measurement of background loss coefficient (BLC) and makes the rate equation of the DOFs simple. It is shown that by using the pseudo parameters values obtained by the proposed techniques, the error in the gain of a designed EDFA with a BLC of about 1 dB/km, are about 0.08 dB. It is further indicated that the same scenario holds good for BLC lower than 5 dB/m and higher than 12 dB/m. The proposed characterization techniques have simple procedures and are low cost that can have an advantageous use in manufacturing of the DOFs.

Robustness analysis of bogie suspension components Pareto optimised values

NASA Astrophysics Data System (ADS)

Mousavi Bideleh, Seyed Milad

2017-08-01

Bogie suspension system of high speed trains can significantly affect vehicle performance. Multiobjective optimisation problems are often formulated and solved to find the Pareto optimised values of the suspension components and improve cost efficiency in railway operations from different perspectives. Uncertainties in the design parameters of suspension system can negatively influence the dynamics behaviour of railway vehicles. In this regard, robustness analysis of a bogie dynamics response with respect to uncertainties in the suspension design parameters is considered. A one-car railway vehicle model with 50 degrees of freedom and wear/comfort Pareto optimised values of bogie suspension components is chosen for the analysis. Longitudinal and lateral primary stiffnesses, longitudinal and vertical secondary stiffnesses, as well as yaw damping are considered as five design parameters. The effects of parameter uncertainties on wear, ride comfort, track shift force, stability, and risk of derailment are studied by varying the design parameters around their respective Pareto optimised values according to a lognormal distribution with different coefficient of variations (COVs). The robustness analysis is carried out based on the maximum entropy concept. The multiplicative dimensional reduction method is utilised to simplify the calculation of fractional moments and improve the computational efficiency. The results showed that the dynamics response of the vehicle with wear/comfort Pareto optimised values of bogie suspension is robust against uncertainties in the design parameters and the probability of failure is small for parameter uncertainties with COV up to 0.1.

Metallographic assessment of Al-12Si high-pressure die casting escalator steps.

PubMed

Vander Voort, George Frederic; Suárez-Peña, Beatriz; Asensio-Lozano, Juan

2014-10-01

A microstructural characterization study was performed on high-pressure die cast specimens extracted from escalator steps manufactured from an Al-12 wt.% Si alloy designed for structural applications. Black and white, color light optical imaging and scanning electron microscopy techniques were used to conduct the microstructural analysis. Most regions in the samples studied contained globular-rosette primary α-Al grains surrounded by an Al-Si eutectic aggregate, while primary dendritic α-Al grains were present in the surface layer. This dendritic microstructure was observed in the regions where the melt did not impinge directly on the die surface during cavity filling. Consequently, microstructures in the surface layer were nonuniform. Utilizing physical metallurgy principles, these results were analyzed in terms of the applied pressure and filling velocity during high-pressure die casting. The effects of these parameters on solidification at different locations of the casting are discussed.

Study of reactor Brayton power systems for nuclear electric spacecraft

NASA Technical Reports Server (NTRS)

1979-01-01

The feasibility of using Brayton power systems for nuclear electric spacecraft was investigated. The primary performance parameters of systems mass and radiator area were determined for systems from 100 to 1000 kW sub e. Mathematical models of all system components were used to determine masses and volumes. Two completely independent systems provide propulsion power so that no single-point failure can jeopardize a mission. The waste heat radiators utilize armored heat pipes to limit meteorite puncture. The armor thickness was statistically determined to achieve the required probability of survival. A 400 kW sub e reference system received primary attention as required by the contract. The components of this system were defined and a conceptual layout was developed with encouraging results. An arrangement with redundant Brayton power systems having a 1500 K (2240 F) turbine inlet temperature was shown to be compatible with the dimensions of the space shuttle orbiter payload bay.

BOREAS RSS-8 BIOME-BGC SSA Simulation of Annual Water and Carbon Fluxes

NASA Technical Reports Server (NTRS)

Hall, Forrest G. (Editor); Nickeson, Jaime (Editor); Kimball, John

2000-01-01

The BOREAS RSS-8 team performed research to evaluate the effect of seasonal weather and landcover heterogeneity on boreal forest regional water and carbon fluxes using a process-level ecosystem model, BIOME-BGC, coupled with remote sensing-derived parameter maps of key state variables. This data set contains derived maps of landcover type and crown and stem biomass as model inputs to determine annual evapotranspiration, gross primary production, autotrophic respiration, and net primary productivity within the BOREAS SSA-MSA, at a 30-m spatial resolution. Model runs were conducted over a 3-year period from 1994-1996; images are provided for each of those years. The data are stored in binary image format. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

Diagnostic performance of semi-quantitative and quantitative stress CMR perfusion analysis: a meta-analysis.

PubMed

van Dijk, R; van Assen, M; Vliegenthart, R; de Bock, G H; van der Harst, P; Oudkerk, M

2017-11-27

Stress cardiovascular magnetic resonance (CMR) perfusion imaging is a promising modality for the evaluation of coronary artery disease (CAD) due to high spatial resolution and absence of radiation. Semi-quantitative and quantitative analysis of CMR perfusion are based on signal-intensity curves produced during the first-pass of gadolinium contrast. Multiple semi-quantitative and quantitative parameters have been introduced. Diagnostic performance of these parameters varies extensively among studies and standardized protocols are lacking. This study aims to determine the diagnostic accuracy of semi- quantitative and quantitative CMR perfusion parameters, compared to multiple reference standards. Pubmed, WebOfScience, and Embase were systematically searched using predefined criteria (3272 articles). A check for duplicates was performed (1967 articles). Eligibility and relevance of the articles was determined by two reviewers using pre-defined criteria. The primary data extraction was performed independently by two researchers with the use of a predefined template. Differences in extracted data were resolved by discussion between the two researchers. The quality of the included studies was assessed using the 'Quality Assessment of Diagnostic Accuracy Studies Tool' (QUADAS-2). True positives, false positives, true negatives, and false negatives were subtracted/calculated from the articles. The principal summary measures used to assess diagnostic accuracy were sensitivity, specificity, andarea under the receiver operating curve (AUC). Data was pooled according to analysis territory, reference standard and perfusion parameter. Twenty-two articles were eligible based on the predefined study eligibility criteria. The pooled diagnostic accuracy for segment-, territory- and patient-based analyses showed good diagnostic performance with sensitivity of 0.88, 0.82, and 0.83, specificity of 0.72, 0.83, and 0.76 and AUC of 0.90, 0.84, and 0.87, respectively. In per territory analysis our results show similar diagnostic accuracy comparing anatomical (AUC 0.86(0.83-0.89)) and functional reference standards (AUC 0.88(0.84-0.90)). Only the per territory analysis sensitivity did not show significant heterogeneity. None of the groups showed signs of publication bias. The clinical value of semi-quantitative and quantitative CMR perfusion analysis remains uncertain due to extensive inter-study heterogeneity and large differences in CMR perfusion acquisition protocols, reference standards, and methods of assessment of myocardial perfusion parameters. For wide spread implementation, standardization of CMR perfusion techniques is essential. CRD42016040176 .

Diagnosis of dynamic process over rainband of landfall typhoon

NASA Astrophysics Data System (ADS)

Ran, Ling-Kun; Yang, Wen-Xia; Chu, Yan-Li

2010-07-01

This paper introduces a new physical parameter — thermodynamic shear advection parameter combining the perturbation vertical component of convective vorticity vector with the coupling of horizontal divergence perturbation and vertical gradient of general potential temperature perturbation. For a heavy-rainfall event resulting from the landfall typhoon 'Wipha', the parameter is calculated by using National Centres for Enviromental Prediction/National Centre for Atmospheric Research global final analysis data. The results showed that the parameter corresponds to the observed 6 h accumulative rainband since it is capable of catching hold of the dynamic and thermodynamic disturbance in the lower troposphere over the observed rainband. Before the typhoon landed, the advection of the parameter by basic-state flow and the coupling of general potential temperature perturbation with curl of Coriolis force perturbation are the primary dynamic processes which are responsible for the local change of the parameter. After the typhoon landed, the disturbance is mainly driven by the combination of five primary dynamic processes. The advection of the parameter by basic-state flow was weakened after the typhoon landed.

Estimation of Mangrove Net Primary Production and Carbon Sequestration service using Light Use Efficiency model in the Sunderban Biosphere region, India

NASA Astrophysics Data System (ADS)

Sannigrahi, Srikanta; Sen, Somnath; Paul, Saikat

2016-04-01

Net Primary Production (NPP) of mangrove ecosystem and its capacity to sequester carbon from the atmosphere may be used to quantify the regulatory ecosystem services. Three major group of parameters has been set up as BioClimatic Parameters (BCP): (Photosynthetically Active Radiation (PAR), Absorbed PAR (APAR), Fraction of PAR (FPAR), Photochemical Reflectance Index (PRI), Light Use Efficiency (LUE)), BioPhysical Parameters (BPP) :(Normalize Difference Vegetation Index (NDVI), scaled NDVI, Enhanced Vegetation Index (EVI), scaled EVI, Optimised and Modified Soil Adjusted Vegetation Index (OSAVI, MSAVI), Leaf Area Index (LAI)), and Environmental Limiting Parameters (ELP) (Temperature Stress (TS), Land Surface Water Index (LSWI), Normalize Soil Water Index (NSWI), Water Stress Scalar (WS), Inversed WS (iWS) Land Surface Temperature (LST), scaled LST, Vapor Pressure Deficit (VPD), scaled VPD, and Soil Water Deficit Index (SWDI)). Several LUE models namely Carnegie Ames Stanford Approach (CASA), Eddy Covariance - LUE (EC-LUE), Global Production Efficiency Model (GloPEM), Vegetation Photosynthesis Model (VPM), MOD NPP model, Temperature and Greenness Model (TG), Greenness and Radiation model (GR) and MOD17 was adopted in this study to assess the spatiotemporal nature of carbon fluxes. Above and Below Ground Biomass (AGB & BGB) was calculated using field based estimation of OSAVI and NDVI. Microclimatic zonation has been set up to assess the impact of coastal climate on environmental limiting factors. MODerate Resolution Imaging Spectroradiometer (MODIS) based yearly Gross Primary Production (GPP) and NPP product MOD17 was also tested with LUE based results with standard model validation statistics: Root Mean Square of Error (RMSE), Mean Absolute Error (MEA), Bias, Coefficient of Variation (CV) and Coefficient of Determination (R2). The performance of CASA NPP was tested with the ground based NPP with R2 = 0.89 RMSE = 3.28 P = 0.01. Among the all adopted models, EC-LUE and VPM models has explained the maximum variances (>80%) in comparison to the other model. Study result has also showed that the BPP has explained the maximum model variances (>93%) followed by BCP (>65%) and ELP (>50%). Scaled WS, iWS, LST, VPD, NDVI was performed better in a minimum ELP condition whereas surface moisture and wetness was highly correlated with the AGB and NPP (R2 = 0.86 RMSE = 1.83). During this study period (2000-2013), it was found that there was a significantly declining trend (R2 = 0.32 P = 0.05) of annual NPP and the maximum decrease was found in the eastern part where built-up area was mainly accounted for reduction of NPP. BCP are explained higher variances (>80%) in the optimum climatic condition exist along the coastal stretches in comparison to the landward extent (>45%).

Optimal experimental design for improving the estimation of growth parameters of Lactobacillus viridescens from data under non-isothermal conditions.

PubMed

Longhi, Daniel Angelo; Martins, Wiaslan Figueiredo; da Silva, Nathália Buss; Carciofi, Bruno Augusto Mattar; de Aragão, Gláucia Maria Falcão; Laurindo, João Borges

2017-01-02

In predictive microbiology, the model parameters have been estimated using the sequential two-step modeling (TSM) approach, in which primary models are fitted to the microbial growth data, and then secondary models are fitted to the primary model parameters to represent their dependence with the environmental variables (e.g., temperature). The Optimal Experimental Design (OED) approach allows reducing the experimental workload and costs, and the improvement of model identifiability because primary and secondary models are fitted simultaneously from non-isothermal data. Lactobacillus viridescens was selected to this study because it is a lactic acid bacterium of great interest to meat products preservation. The objectives of this study were to estimate the growth parameters of L. viridescens in culture medium from TSM and OED approaches and to evaluate both the number of experimental data and the time needed in each approach and the confidence intervals of the model parameters. Experimental data for estimating the model parameters with TSM approach were obtained at six temperatures (total experimental time of 3540h and 196 experimental data of microbial growth). Data for OED approach were obtained from four optimal non-isothermal profiles (total experimental time of 588h and 60 experimental data of microbial growth), two profiles with increasing temperatures (IT) and two with decreasing temperatures (DT). The Baranyi and Roberts primary model and the square root secondary model were used to describe the microbial growth, in which the parameters b and T min (±95% confidence interval) were estimated from the experimental data. The parameters obtained from TSM approach were b=0.0290 (±0.0020) [1/(h 0.5 °C)] and T min =-1.33 (±1.26) [°C], with R 2 =0.986 and RMSE=0.581, and the parameters obtained with the OED approach were b=0.0316 (±0.0013) [1/(h 0.5 °C)] and T min =-0.24 (±0.55) [°C], with R 2 =0.990 and RMSE=0.436. The parameters obtained from OED approach presented smaller confidence intervals and best statistical indexes than those from TSM approach. Besides, less experimental data and time were needed to estimate the model parameters with OED than TSM. Furthermore, the OED model parameters were validated with non-isothermal experimental data with great accuracy. In this way, OED approach is feasible and is a very useful tool to improve the prediction of microbial growth under non-isothermal condition. Copyright © 2016 Elsevier B.V. All rights reserved.

Anatomical manifestations of primary blast ocular trauma observed in a postmortem porcine model.

PubMed

Sherwood, Daniel; Sponsel, William E; Lund, Brian J; Gray, Walt; Watson, Richard; Groth, Sylvia L; Thoe, Kimberly; Glickman, Randolph D; Reilly, Matthew A

2014-02-24

We qualitatively describe the anatomic features of primary blast ocular injury observed using a postmortem porcine eye model. Porcine eyes were exposed to various levels of blast energy to determine the optimal conditions for future testing. We studied 53 enucleated porcine eyes: 13 controls and 40 exposed to a range of primary blast energy levels. Eyes were preassessed with B-scan and ultrasound biomicroscopy (UBM) ultrasonography, photographed, mounted in gelatin within acrylic orbits, and monitored with high-speed videography during blast-tube impulse exposure. Postimpact photography, ultrasonography, and histopathology were performed, and ocular damage was assessed. Evidence for primary blast injury was obtained. While some of the same damage was observed in the control eyes, the incidence and severity of this damage in exposed eyes increased with impulse and peak pressure, suggesting that primary blast exacerbated these injuries. Common findings included angle recession, internal scleral delamination, cyclodialysis, peripheral chorioretinal detachments, and radial peripapillary retinal detachments. No full-thickness openings of the eyewall were observed in any of the eyes tested. Scleral damage demonstrated the strongest associative tendency for increasing likelihood of injury with increased overpressure. These data provide evidence that primary blast alone (in the absence of particle impact) can produce clinically relevant ocular damage in a postmortem model. The blast parameters derived from this study are being used currently in an in vivo model. We also propose a new Cumulative Injury Score indicating the clinical relevance of observed injuries.

Time-resolved characterization of primary and secondary particle emissions of a modern gasoline passenger car

NASA Astrophysics Data System (ADS)

Karjalainen, P.; Timonen, H.; Saukko, E.; Kuuluvainen, H.; Saarikoski, S.; Aakko-Saksa, P.; Murtonen, T.; Dal Maso, M.; Ahlberg, E.; Svenningsson, B.; Brune, W. H.; Hillamo, R.; Keskinen, J.; Rönkkö, T.

2015-11-01

Changes in traffic systems and vehicle emission reduction technologies significantly affect traffic-related emissions in urban areas. In many densely populated areas the amount of traffic is increasing, keeping the emission level high or even increasing. To understand the health effects of traffic related emissions, both primary and secondary particles that are formed in the atmosphere from gaseous exhaust emissions need to be characterized. In this study we used a comprehensive set of measurements to characterize both primary and secondary particulate emissions of a modern gasoline passenger car. Our aerosol particle study covers the whole process chain in emission formation, from the engine to the atmosphere, and takes into account also differences in driving patterns. We observed that in mass terms, the amount of secondary particles was 13 times higher than the amount of primary particles. The formation, composition, number, and mass of secondary particles was significantly affected by driving patterns and engine conditions. The highest gaseous and particulate emissions were observed at the beginning of the test cycle when the performance of the engine and the catalyst was below optimal. The key parameter for secondary particle formation was the amount of gaseous hydrocarbons in primary emissions; however, also the primary particle population had an influence. Thus, in order to enhance human health and wellbeing in urban areas, our study strongly indicates that in future legislation, special attention should be directed into the reduction of gaseous hydrocarbons.

Improving Lifetime of Quasi-CW Laser Diode Arrays for Pumping 2-Micron Solid State Lasers

NASA Technical Reports Server (NTRS)

Amzajerdian, Farzin; Meadows, Byron L.; Baker, Nathaniel R.; Barnes, Bruce W.; Singh, Upendra N.; Kavaya, Michael J.

2007-01-01

Operating high power laser diode arrays in long pulse regime of about 1 msec, which is required for pumping 2-micron thulium and holmium-based lasers, greatly limits their useful lifetime. This paper describes performance of laser diode arrays operating in long pulse mode and presents experimental data on the active region temperature and pulse-to-pulse thermal cycling that are the primary cause of their premature failure and rapid degradation. This paper will then offer a viable approach for determining the optimum design and operational parameters leading to the maximum attainable lifetime.

Improving Reliability of High Power Quasi-CW Laser Diode Arrays Operating in Long Pulse Mode

NASA Technical Reports Server (NTRS)

Amzajerdian, Farzin; Meadows, Byron L.; Barnes, Bruce W.; Lockard, George E.; Singh, Upendra N.; Kavaya, Michael J.; Baker, Nathaniel R.

2006-01-01

Operating high power laser diode arrays in long pulse regime of about 1 msec, which is required for pumping 2-micron thulium and holmium-based lasers, greatly limits their useful lifetime. This paper describes performance of laser diode arrays operating in long pulse mode and presents experimental data of the active region temperature and pulse-to-pulse thermal cycling that are the primary cause of their premature failure and rapid degradation. This paper will then offer a viable approach for determining the optimum design and operational parameters leading to the maximum attainable lifetime.

Percutaneous Trigger Finger Release: A Cost-effectiveness Analysis.

PubMed

Gancarczyk, Stephanie M; Jang, Eugene S; Swart, Eric P; Makhni, Eric C; Kadiyala, Rajendra Kumar

2016-07-01

Percutaneous trigger finger releases (TFRs) performed in the office setting are becoming more prevalent. This study compares the costs of in-hospital open TFRs, open TFRs performed in ambulatory surgical centers (ASCs), and in-office percutaneous releases. An expected-value decision-analysis model was constructed from the payer perspective to estimate total costs of the three competing treatment strategies for TFR. Model parameters were estimated based on the best available literature and were tested using multiway sensitivity analysis. Percutaneous TFR performed in the office and then, if needed, revised open TFR performed in the ASC, was the most cost-effective strategy, with an attributed cost of $603. The cost associated with an initial open TFR performed in the ASC was approximately 7% higher. Initial open TFR performed in the hospital was the least cost-effective, with an attributed cost nearly twice that of primary percutaneous TFR. An initial attempt at percutaneous TFR is more cost-effective than an open TFR. Currently, only about 5% of TFRs are performed in the office; therefore, a substantial opportunity exists for cost savings in the future. Decision model level II.

Demographic variation across successional stages and their effects on the population dynamics of the neotropical palm Euterpe precatoria.

PubMed

Otárola, Mauricio Fernández; Avalos, Gerardo

2014-06-01

• Premise of the study: Environmental heterogeneity is a strong selective force shaping adaptation and population dynamics across temporal and spatial scales. Natural and anthropogenic gradients influence the variation of environmental and biotic factors, which determine population demography and dynamics. Successional gradients are expected to influence demographic parameters, but the relationship between these gradients and the species life history, habitat requirements, and degree of variation in demographic traits remains elusive.• Methods: We used the palm Euterpe precatoria to test the effect of successional stage on plant demography within a continuous population. We calculated demographic parameters for size stages and performed matrix analyses to investigate the demographic variation within primary and secondary forests of La Selva, Costa Rica.• Key results: We observed differences in mortality and recruitment of small juveniles between primary and secondary forests. Matrix models described satisfactorily the chronosequence of population changes, which were characterized by high population growth rate in disturbed areas, and decreased growth rate in old successional forests until reaching stability.• Conclusions: Different demographic parameters can be expressed in contiguous subpopulations along a gradient of successional stages with important consequences for population dynamics. Demographic variation superimposed on these gradients contributes to generate subpopulations with different demographic composition, density, and ecological properties. Therefore, the effects of spatial variation must be reconsidered in the design of demographic analyses of tropical palms, which are prime examples of subtle local adaptation. These considerations are crucial in the implementation of management plans for palm species within spatially complex and heterogeneous tropical landscapes. © 2014 Botanical Society of America, Inc.

Changes in the retrobulbar arterial circulation after decrease of elevated intraocular pressue in patients with primary open angle glaucoma.

PubMed

Marjanović, Ivan; Sundić, Ana; Mijajlović, Milija; Covicković-Sternić, Nadezda; Kontić, Djordje; Hentova-Senćanić, Paraskeva; Marković, Vujica; Bozić, Marija; Knezević, Miroslav

2011-01-01

An altered perfusion of the optic nerve head has been proposed as a pathogenic factor in glaucoma. To evaluate changes of haemodynamic parameters in the retrobulbar arterial circulation after a decrease of elevated intraocular pressure (IOP) in patients with primary open angle glaucoma (POAG). Twenty-six patients were examined, 14 men and 12 women, 21 up to 50 years old and 5 below, all with previously diagnosed and treated POAG, and all examined at the Eye Clinic, Clinical Centre of Serbia. IOP was measured both with a Goldmann aplanation tonometer and dynamic contour tonometer. Central corneal thickness was measured with ultrasound pachymeter. Imaging of the retrobulbar arterial circulation by colour Doppler was performed at the Neurology Clinic, Clinical Centre of Serbia. It involved measuring of haemodynamic parameters of the ophthalmic artery, central retinal artery, and posterior ciliary arteries. Peak systolic velocity (PSV) and end-diastolic velocity (EDV) were measured, and resistive index (RI) and pulsatility index (PI) were calculated. Haemodynamic arterial parameters PSV and EDV in the ophthalmic and central retinal artery after decrease of IOP were lower, while RI and PI were higher. In the posterior ciliary arteries PSV, EDV and PI were lower, and RI was higher. Changes of the retrobulbar arterial circulation after elevated LOP in POAG patients are important for approach and treatment, while the role of vascular factors in the supplement of the optic disc neuroretinal rim could be a key for progression backlash of glaucoma and the radix of neuroprotection.

Repeated assessment of suspected normal pressure hydrocephalus in non-shunted cases. A prospective study based on the constant rate lumbar infusion test.

PubMed

Czepko, Ryszard; Cieslicki, Krzysztof

2016-05-01

Only a few reports have been published on the natural history of non-shunted patients suspected of having NPH. The aim of this study is to follow up a group of such cases. It was possible to follow up 27 patients who had not been qualified for shunting after the primary diagnosis. An assessment of Hakim's triad was performed, together with an analysis of radiological parameters and the results of lumbar infusion tests (LITs), both on admission and at the later date (on average, after 5.6 months). All parameters were analyzed with respect to periventricular lucency (PVL), atrophy, type of NPH, and the age of the patients. There were no deteriorations and six patients improved. Those who were over 50 and who had no PVL or secondary NPH tended to improve more frequently. Significant improvement of dementia was noted (p = 0.042) in all cases, and in the group of patients without PVL (p = 0.04). The size of the ventricles did not change significantly. The values of the resistance to outflow (R), elastance (E), and ICP remained stable. Analysis of our series revealed that the patients suspected of having NPH who had not been qualified for shunting did not deteriorate, while some of them even improved significantly as far as the level of dementia was concerned. As the CT and LIT parameters remained stable, there were no indications for repeating these examinations, at least within the period of nearly 6 months, which followed the primary diagnosis.

An articulatorily constrained, maximum entropy approach to speech recognition and speech coding

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hogden, J.

Hidden Markov models (HMM`s) are among the most popular tools for performing computer speech recognition. One of the primary reasons that HMM`s typically outperform other speech recognition techniques is that the parameters used for recognition are determined by the data, not by preconceived notions of what the parameters should be. This makes HMM`s better able to deal with intra- and inter-speaker variability despite the limited knowledge of how speech signals vary and despite the often limited ability to correctly formulate rules describing variability and invariance in speech. In fact, it is often the case that when HMM parameter values aremore » constrained using the limited knowledge of speech, recognition performance decreases. However, the structure of an HMM has little in common with the mechanisms underlying speech production. Here, the author argues that by using probabilistic models that more accurately embody the process of speech production, he can create models that have all the advantages of HMM`s, but that should more accurately capture the statistical properties of real speech samples--presumably leading to more accurate speech recognition. The model he will discuss uses the fact that speech articulators move smoothly and continuously. Before discussing how to use articulatory constraints, he will give a brief description of HMM`s. This will allow him to highlight the similarities and differences between HMM`s and the proposed technique.« less

Biaxial Creep Specimen Fabrication

DOE Office of Scientific and Technical Information (OSTI.GOV)

JL Bump; RF Luther

This report documents the results of the weld development and abbreviated weld qualification efforts performed by Pacific Northwest National Laboratory (PNNL) for refractory metal and superalloy biaxial creep specimens. Biaxial creep specimens were to be assembled, electron beam welded, laser-seal welded, and pressurized at PNNL for both in-pile (JOYO reactor, O-arai, Japan) and out-of-pile creep testing. The objective of this test campaign was to evaluate the creep behavior of primary cladding and structural alloys under consideration for the Prometheus space reactor. PNNL successfully developed electron beam weld parameters for six of these materials prior to the termination of the Navalmore » Reactors program effort to deliver a space reactor for Project Prometheus. These materials were FS-85, ASTAR-811C, T-111, Alloy 617, Haynes 230, and Nirnonic PE16. Early termination of the NR space program precluded the development of laser welding parameters for post-pressurization seal weldments.« less

An experimental study of the effect of tail configuration on the spinning characteristics of general aviation aircraft. M.S. Thesis; [static wind tunnel force measurements

NASA Technical Reports Server (NTRS)

Ballin, M. G.

1982-01-01

The feasibility of using static wind tunnel tests to obtain information about spin damping characteristics of an isolated general aviation aircraft tail was investigated. A representative tail section was oriented to the tunnel free streamline at angles simulating an equilibrium spin. A full range of normally encountered spin conditions was employed. Results of parametric studies performed to determine the effect of spin damping on several tail design parameters show satisfactory agreement with NASA rotary balance tests. Wing and body interference effects are present in the NASA studies at steep spin attitudes, but agreement improves with increasing pitch angle and spin rate, suggesting that rotational flow effects are minimal. Vertical position of the horizontal stabilizer is found to be a primary parameter affecting yaw damping, and horizontal tail chordwise position induces a substantial effect on pitching moment.

Supersonic plasma outflow in a plasmochemical method of amorphous silicon thin films formation

NASA Astrophysics Data System (ADS)

Baranova, L. V.; Strunin, V. I.; Khudaibergenov, G. Zh

2018-01-01

As a result of the numerical modeling of gasdynamic functions of a nozzle of Laval there obtained its parameters which form supersonic plasma jet outflow in a process of amorphous silicon thin films deposition. According to the nozzle design parameters, there obtained amorphous silicon thin films and studied uniformity of the thickness of the synthesized coatings. It was also performed that due to a low translational temperature at the nozzle exit the relaxation losses reduce significantly, “freezing” the vibrational degrees of freedom and the degrees of freedom of the transverse motion of the particles, and increasing the energy efficiency of the film formation process. All this is caused by the fact that on the surface of a growing film only the products of primary interaction of electrons with molecules of a silicon-containing gas in the plasmatron do interact.

Orbit Selection for Earth Observation Missions

NASA Technical Reports Server (NTRS)

King, J. C.

1978-01-01

The orbit selection process is simplified for most earth-oriented satellite missions by a restriction to circular orbits, which reduces the primary orbit characteristics to be determined to only two: altitude and inclination. A number of important mission performance characteristics depend on these choices, however, so a major part of the orbit selection task is concerned with developing the correlating relationships in clear and convenient forms to provide a basis for rational orbit selection procedures. The present approach to that task is organized around two major areas of mission performance, orbit plane precession and coverage pattern development, whose dependence on altitude and inclination is delineated graphically in design chart form. These charts provide a visual grasp of the relationships between the quantities cited above, as well as other important mission performance parameters including viewing time of day (solar), sensor swath width (and fields of view), swath sequencing, and pattern repeat condition and repeat periods.

Motion in a modified Chermnykh's restricted three-body problem with oblateness

NASA Astrophysics Data System (ADS)

Singh, Jagadish; Leke, Oni

2014-03-01

In this paper, the restricted problem of three bodies is generalized to include a case when the passively gravitating test particle is an oblate spheroid under effect of small perturbations in the Coriolis and centrifugal forces when the first primary is a source of radiation and the second one an oblate spheroid, coupled with the influence of the gravitational potential from the belt. The equilibrium points are found and it is seen that, in addition to the usual three collinear equilibrium points, there appear two new ones due to the potential from the belt and the mass ratio. Two triangular equilibrium points exist. These equilibria are affected by radiation of the first primary, small perturbation in the centrifugal force, oblateness of both the test particle and second primary and the effect arising from the mass of the belt. The linear stability of the equilibrium points is explored and the stability outcome of the collinear equilibrium points remains unstable. In the case of the triangular points, motion is stable with respect to some conditions which depend on the critical mass parameter; influenced by the small perturbations, radiating effect of the first primary, oblateness of the test body and second primary and the gravitational potential from the belt. The effects of each of the imposed free parameters are analyzed. The potential from the belt and small perturbation in the Coriolis force are stabilizing parameters while radiation, small perturbation in the centrifugal force and oblateness reduce the stable regions. The overall effect is that the region of stable motion increases under the combine action of these parameters. We have also found the frequencies of the long and short periodic motion around stable triangular points. Illustrative numerical exploration is rendered in the Sun-Jupiter and Sun-Earth systems where we show that in reality, for some values of the system parameters, the additional equilibrium points do not in general exist even when there is a belt to interact with.

In-Flight Calibration Processes for the MMS Fluxgate Magnetometers

NASA Technical Reports Server (NTRS)

Bromund, K. R.; Leinweber, H. K.; Plaschke, F.; Strangeway, R. J.; Magnes, W.; Fischer, D.; Nakamura, R.; Anderson, B. J.; Russell, C. T.; Baumjohann, W.;

Computational intelligence-based optimization of maximally stable extremal region segmentation for object detection

NASA Astrophysics Data System (ADS)

Davis, Jeremy E.; Bednar, Amy E.; Goodin, Christopher T.; Durst, Phillip J.; Anderson, Derek T.; Bethel, Cindy L.

2017-05-01

Particle swarm optimization (PSO) and genetic algorithms (GAs) are two optimization techniques from the field of computational intelligence (CI) for search problems where a direct solution can not easily be obtained. One such problem is finding an optimal set of parameters for the maximally stable extremal region (MSER) algorithm to detect areas of interest in imagery. Specifically, this paper describes the design of a GA and PSO for optimizing MSER parameters to detect stop signs in imagery produced via simulation for use in an autonomous vehicle navigation system. Several additions to the GA and PSO are required to successfully detect stop signs in simulated images. These additions are a primary focus of this paper and include: the identification of an appropriate fitness function, the creation of a variable mutation operator for the GA, an anytime algorithm modification to allow the GA to compute a solution quickly, the addition of an exponential velocity decay function to the PSO, the addition of an "execution best" omnipresent particle to the PSO, and the addition of an attractive force component to the PSO velocity update equation. Experimentation was performed with the GA using various combinations of selection, crossover, and mutation operators and experimentation was also performed with the PSO using various combinations of neighborhood topologies, swarm sizes, cognitive influence scalars, and social influence scalars. The results of both the GA and PSO optimized parameter sets are presented. This paper details the benefits and drawbacks of each algorithm in terms of detection accuracy, execution speed, and additions required to generate successful problem specific parameter sets.

Development of an Object-Oriented Turbomachinery Analysis Code within the NPSS Framework

NASA Technical Reports Server (NTRS)

Jones, Scott M.

2014-01-01

During the preliminary or conceptual design phase of an aircraft engine, the turbomachinery designer has a need to estimate the effects of a large number of design parameters such as flow size, stage count, blade count, radial position, etc. on the weight and efficiency of a turbomachine. Computer codes are invariably used to perform this task however, such codes are often very old, written in outdated languages with arcane input files, and rarely adaptable to new architectures or unconventional layouts. Given the need to perform these kinds of preliminary design trades, a modern 2-D turbomachinery design and analysis code has been written using the Numerical Propulsion System Simulation (NPSS) framework. This paper discusses the development of the governing equations and the structure of the primary objects used in OTAC.

The study of microstrip antenna arrays and related problems

NASA Technical Reports Server (NTRS)

Lo, Y. T.

1986-01-01

In February, an initial computer program to be used in analyzing the four-element array module was completed. This program performs the analysis of modules composed of four rectangular patches which are corporately fed by a microstrip line network terminated in four identical load impedances. Currently, a rigorous full-wave analysis of various types of microstrip line feed structures and patches is being performed. These tests include the microstrip line feed between layers of different electrical parameters. A method of moments was implemented for the case of a single dielectric layer and microstrip line fed rectangular patches in which the primary source is assumed to be a magnetic current ribbon across the line some distance from the patch. Measured values are compared with those computed by the program.

Can the fluctuations of motion be used to estimate the performance of kayak paddlers?

NASA Astrophysics Data System (ADS)

Vadai, Gergely; Gingl, Zoltán

2016-05-01

Today many compact and efficient on-water data acquisition units help modern coaching by measuring and analyzing various inertial signals during kayaking. One of the most challenging problems is how these signals can be used to estimate performance and to develop the technique. Recently we have introduced indicators based on the fluctuations of the inertial signals as promising additions to the existing parameters. In this work we report on our more detailed analysis, compare new indicators, and discuss the possible advantages of the applied methods. Our primary aim is to draw attention to several exciting and inspiring open problems and to initiate further research even in several related multidisciplinary fields. More detailed information can be found on the dedicated webpage, www.noise.inf.u-szeged.hu/kayak.

Performance of convolutionally encoded noncoherent MFSK modem in fading channels

NASA Technical Reports Server (NTRS)

Modestino, J. W.; Mui, S. Y.

1976-01-01

The performance of a convolutionally encoded noncoherent multiple-frequency shift-keyed (MFSK) modem utilizing Viterbi maximum-likelihood decoding and operating on a fading channel is described. Both the lognormal and classical Rician fading channels are considered for both slow and time-varying channel conditions. Primary interest is in the resulting bit error rate as a function of the ratio between the energy per transmitted information bit and noise spectral density, parameterized by both the fading channel and code parameters. Fairly general upper bounds on bit error probability are provided and compared with simulation results in the two extremes of zero and infinite channel memory. The efficacy of simple block interleaving in combatting channel memory effects are thoroughly explored. Both quantized and unquantized receiver outputs are considered.

The All-Particle Spectrum of Primary Cosmic Rays in the Wide Energy Range from 10{sup 14} to 10{sup 17} eV Observed with the Tibet-III Air-Shower Array

DOE Office of Scientific and Technical Information (OSTI.GOV)

Amenomori, M.; Bi, X. J.; Ding, L. K.

2008-05-10

We present an updated all-particle energy spectrum of primary cosmic rays in a wide range from 10{sup 14} to 10{sup 17} eV using 5.5 x 10{sup 7} events collected from 2000 November through 2004 October by the Tibet-III air-shower array located 4300 m above sea level (an atmospheric depth of 606 g cm{sup -2}). The size spectrum exhibits a sharp knee at a corresponding primary energy around 4 PeV. This work uses increased statistics and new simulation calculations for the analysis. We discuss our extensive Monte Carlo calculations and the model dependencies involved in the final result, assuming interaction modelsmore » QGSJET01c and SIBYLL2.1, and heavy dominant (HD) and proton dominant (PD) primary composition models. Pure proton and pure iron primary models are also examined as extreme cases. A detector simulation was also performed to improve our accuracy in determining the size of the air showers and the energy of the primary particle. We confirmed that the all-particle energy spectra obtained under various plausible model parameters are not significantly different from each other, which was the expected result given the characteristics of the experiment at high altitude, where the air showers of the primary energy around the knee reach near-maximum development, with their features dominated by electromagnetic components, leading to a weak dependence on the interaction model or the primary mass. This is the highest statistical and the best systematics-controlled measurement covering the widest energy range around the knee energy region.« less

Prognostic Value of Pretherapeutic Tumor-to-Blood Standardized Uptake Ratio in Patients with Esophageal Carcinoma.

PubMed

Bütof, Rebecca; Hofheinz, Frank; Zöphel, Klaus; Stadelmann, Tobias; Schmollack, Julia; Jentsch, Christina; Löck, Steffen; Kotzerke, Jörg; Baumann, Michael; van den Hoff, Jörg

2015-08-01

Despite ongoing efforts to develop new treatment options, the prognosis for patients with inoperable esophageal carcinoma is still poor and the reliability of individual therapy outcome prediction based on clinical parameters is not convincing. The aim of this work was to investigate whether PET can provide independent prognostic information in such a patient group and whether the tumor-to-blood standardized uptake ratio (SUR) can improve the prognostic value of tracer uptake values. (18)F-FDG PET/CT was performed in 130 consecutive patients (mean age ± SD, 63 ± 11 y; 113 men, 17 women) with newly diagnosed esophageal cancer before definitive radiochemotherapy. In the PET images, the metabolically active tumor volume (MTV) of the primary tumor was delineated with an adaptive threshold method. The blood standardized uptake value (SUV) was determined by manually delineating the aorta in the low-dose CT. SUR values were computed as the ratio of tumor SUV and blood SUV. Uptake values were scan-time-corrected to 60 min after injection. Univariate Cox regression and Kaplan-Meier analysis with respect to overall survival (OS), distant metastases-free survival (DM), and locoregional tumor control (LRC) was performed. Additionally, a multivariate Cox regression including clinically relevant parameters was performed. In multivariate Cox regression with respect to OS, including T stage, N stage, and smoking state, MTV- and SUR-based parameters were significant prognostic factors for OS with similar effect size. Multivariate analysis with respect to DM revealed smoking state, MTV, and all SUR-based parameters as significant prognostic factors. The highest hazard ratios (HRs) were found for scan-time-corrected maximum SUR (HR = 3.9) and mean SUR (HR = 4.4). None of the PET parameters was associated with LRC. Univariate Cox regression with respect to LRC revealed a significant effect only for N stage greater than 0 (P = 0.048). PET provides independent prognostic information for OS and DM but not for LRC in patients with locally advanced esophageal carcinoma treated with definitive radiochemotherapy in addition to clinical parameters. Among the investigated uptake-based parameters, only SUR was an independent prognostic factor for OS and DM. These results suggest that the prognostic value of tracer uptake can be improved when characterized by SUR instead of SUV. Further investigations are required to confirm these preliminary results. © 2015 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

On designing for quality

NASA Technical Reports Server (NTRS)

Vajingortin, L. D.; Roisman, W. P.

1991-01-01

The problem of ensuring the required quality of products and/or technological processes often becomes more difficult due to the fact that there is not general theory of determining the optimal sets of value of the primary factors, i.e., of the output parameters of the parts and units comprising an object and ensuring the correspondence of the object's parameters to the quality requirements. This is the main reason for the amount of time taken to finish complex vital article. To create this theory, one has to overcome a number of difficulties and to solve the following tasks: the creation of reliable and stable mathematical models showing the influence of the primary factors on the output parameters; finding a new technique of assigning tolerances for primary factors with regard to economical, technological, and other criteria, the technique being based on the solution of the main problem; well reasoned assignment of nominal values for primary factors which serve as the basis for creating tolerances. Each of the above listed tasks is of independent importance. An attempt is made to give solutions for this problem. The above problem dealing with quality ensuring an mathematically formalized aspect is called the multiple inverse problem.

Influence of Stepped Osteotomy on Primary Stability of Implants Inserted in Low-Density Bone Sites: An In Vitro Study.

PubMed

Degidi, Marco; Daprile, Giuseppe; Piattelli, Adriano

The aims of this study were to evaluate the ability of a stepped osteotomy to improve dental implant primary stability in low-density bone sites and to investigate possible correlations between primary stability parameters. The study was performed on fresh humid bovine bone classified as type III. The test group consisted of 30 Astra Tech EV implants inserted following the protocol provided by the manufacturer. The first control group consisted of 30 Astra Tech EV implants inserted in sites without the underpreparation of the apical portion. The second control group consisted of 30 Astra Tech TX implants inserted following the protocol provided by the manufacturer. Implant insertion was performed at the predetermined 30 rpm. The insertion torque data were recorded and exported as a curve; using a trapezoidal integration technique, the area underlying the curve was calculated: this area represents the variable torque work (VTW). Peak insertion torque (pIT) and resonance frequency analysis (RFA) were also recorded. A Mann-Whitney test showed that the mean VTW was significantly higher in the test group compared with the first control and second control groups; furthermore, statistical analysis showed that pIT also was significantly higher in the test group compared with the first and second control groups. Analyzing RFA values, only the difference between the test group and second control group showed statistical significance. Pearson correlation analysis showed a very strong positive correlation between pIT and VTW values in all groups; furthermore, it showed a positive correlation between pIT and RFA values and between VTW and RFA values only in the test group. Within the limitations of an in vitro study, the results show that stepped osteotomy can be a viable method to improve implant primary stability in low-density bone sites, and that, when a traditional osteotomy method is performed, RFA presents no correlation with pIT and VTW.

Pumping tests in non-uniform aquifers - the linear strip case

USGS Publications Warehouse

Butler, J.J.; Liu, W.Z.

1991-01-01

Many pumping tests are performed in geologic settings that can be conceptualized as a linear infinite strip of one material embedded in a matrix of differing flow properties. A semi-analytical solution is presented to aid the analysis of drawdown data obtained from pumping tests performed in settings that can be represented by such a conceptual model. Integral transform techniques are employed to obtain a solution in transform space that can be numerically inverted to real space. Examination of the numerically transformed solution reveals several interesting features of flow in this configuration. If the transmissivity of the strip is much higher than that of the matrix, linear and bilinear flow are the primary flow regimes during a pumping test. If the contrast between matrix and strip properties is not as extreme, then radial flow should be the primary flow mechanism. Sensitivity analysis is employed to develop insight into the controls on drawdown in this conceptual model and to demonstrate the importance of temporal and spatial placement of observations. Changes in drawdown are sensitive to the transmissivity of the strip for a limited time duration. After that time, only the total drawdown remains a function of strip transmissivity. In the case of storativity, both the total drawdown and changes in drawdown are sensitive to the storativity of the strip for a time of quite limited duration. After that time, essentially no information can be gained about the storage properties of the strip from drawdown data. An example analysis is performed using data previously presented in the literature to demonstrate the viability of the semi-analytical solution and to illustrate a general procedure for analysis of drawdown data in complex geologic settings. This example reinforces the importance of observation well placement and the time of data collection in constraining parameter correlation, a major source of the uncertainty that arises in the parameter estimation procedure. ?? 1991.

Post waterflood CO{sub 2} miscible flood in light oil, fluvial-dominated deltaic reservoir. Annual report, fiscal year 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-08-15

The Port Neches CO{sub 2} flood has been operating for nearly 4 years. The project performance during the past year has been adversely affected by several factors including: water blockage, low residual oil saturation and wellbore mechanical problems. The company attempted to test a new procedure in a new fault block using CO{sub 2} to accelerate primary production in order to improve the primary reserves net present value. The test was abandoned when the discovery well Polk B-39 for the Marg Area 3 was a dry hole. Also, during this period the company terminated all new CO{sub 2} purchases frommore » Cardox for economical reasons, while continuing to recycle produced CO{sub 2}. A data base for FDD reservoirs for the Louisiana and Texas Gulf Coast Region was developed by LSU and SAIC. This data base includes reservoir parameters and performance data for reservoirs with significant production and OOIP volumes that are amenable to CO{sub 2} injection. A paper discussing the Port Neches CO{sub 2} project was presented at the 1996 SPE/DOE Symposium on Improved Oil Recovery.« less

a Simulation Tool Assisting the Design of a Close Range Photogrammetry System for the Sardinia Radio Telescope

NASA Astrophysics Data System (ADS)

Buffa, F.; Pinna, A.; Sanna, G.

2016-06-01

The Sardinia Radio Telescope (SRT) is a 64 m diameter antenna, whose primary mirror is equipped with an active surface capable to correct its deformations by means of a thick network of actuators. Close range photogrammetry (CRP) was used to measure the self-load deformations of the SRT primary reflector from its optimal shape, which are requested to be minimized for the radio telescope to operate at full efficiency. In the attempt to achieve such performance, we conceived a near real-time CRP system which requires the cameras to be installed in fixed positions and at the same time to avoid any interference with the antenna operativeness. The design of such system is not a trivial task, and to assist our decision we therefore developed a simulation pipeline to realistically reproduce and evaluate photogrammetric surveys of large structures. The described simulation environment consists of (i) a detailed description of the SRT model, included the measurement points and the camera parameters, (ii) a tool capable of generating realistic images accordingly to the above model, and (iii) a self-calibrating bundle adjustment to evaluate the performance in terms of RMSE of the camera configurations.

Performance of coded MFSK in a Rician fading channel. [Multiple Frequency Shift Keyed modulation

NASA Technical Reports Server (NTRS)

Modestino, J. W.; Mui, S. Y.

1975-01-01

The performance of convolutional codes in conjunction with noncoherent multiple frequency shift-keyed (MFSK) modulation and Viterbi maximum likelihood decoding on a Rician fading channel is examined in detail. While the primary motivation underlying this work has been concerned with system performance on the planetary entry channel, it is expected that the results are of considerably wider interest. Particular attention is given to modeling the channel in terms of a few meaningful parameters which can be correlated closely with the results of theoretical propagation studies. Fairly general upper bounds on bit error probability performance in the presence of fading are derived and compared with simulation results using both unquantized and quantized receiver outputs. The effects of receiver quantization and channel memory are investigated and it is concluded that the coded noncoherent MFSK system offers an attractive alternative to coherent BPSK in providing reliable low data rate communications in fading channels typical of planetary entry missions.

Reactor/Brayton power systems for nuclear electric spacecraft

NASA Technical Reports Server (NTRS)

Layton, J. P.

1980-01-01

Studies are currently underway to assess the technological feasibility of a nuclear-reactor-powered spacecraft propelled by electric thrusters. This vehicle would be capable of performing detailed exploration of the outer planets of the solar system during the remainder of this century. The purpose of this study was to provide comparative information on a closed cycle gas turbine power conversion system. The results have shown that the performance is very competitive and that a 400 kWe space power system is dimensionally compatible with a single Space Shuttle launch. Performance parameters of system mass and radiator area were determined for systems from 100 to 1000 kWe. A 400 kWe reference system received primary attention. The components of this system were defined and a conceptual layout was developed with encouraging results. The preliminary mass determination for the complete power system was very close to the desired goal of 20 kg/kWe. Use of more advanced technology (higher turbine inlet temperature) will substantially improve system performance characteristics.

Factors Contributing to the Current Academic Performance of Both Private Primary Schools and Public Primary Schools: A Case of Kitale Municipality, Kenya

ERIC Educational Resources Information Center

Catherine, Ochenje

2015-01-01

There have been current controversial discussions concerning the performance of private primary schools versus public primary schools in the Kenya Certificate of Primary Examination (K.C.P.E.). Lately, the private primary schools appear to be performing better than public primary schools. For example; in the 2003 K.C.P.E. results, more than 31% of…

Optic disc size and other parameters from optical coherence tomography in Vietnamese-Americans.

PubMed

Peng, Pai-Huei; Fu, Sheena; Nguyen, Ngoc; Porco, Travis; Lin, Shan C

2011-08-01

To investigate the optic disc parameters by optical coherence tomography (OCT) in Vietnamese with various types of glaucoma. Medical charts of Vietnamese and White patients within a single practice were reviewed. Disc and rim areas by OCT were compared among nonglaucoma controls, different types of glaucoma, and glaucoma suspect. The association of these parameters with demographic and ocular features was evaluated. Data from 1416 Vietnamese and 57 White patients were included. A larger mean disc area was observed in eyes with primary angle-closure glaucoma than in eyes with primary angle-closure and primary angle-closure suspect (both P<0.001). There was no association between disc size with central corneal thickness (P=0.051) and sex (P=0.155). Vietnamese patients with glaucoma and glaucoma suspicion had larger discs than diagnosis-matched Whites (P=0.043 and 0.021, respectively). Vietnamese patients with glaucoma seem to have larger optic discs than White patients. Central corneal thickness had no association with disc area in this study population.

Changes in ocular biometry and anterior chamber parameters after pharmacologic mydriasis and peripheral iridotomy in primary angle closure suspects.

PubMed

Razeghinejad, Mohammad Reza; Lashkarizadeh, Hamid; Nowroozzadeh, Mohammad Hossein; Yazdanmehr, Mohammad

2016-01-01

The aim of this study was to evaluate the effects of pharmacologic mydriasis and Peripheral Iridotomy (PI) on ocular biometry and anterior chamber parameters in primary angle closure suspects. In this prospective interventional case series, 21 primary angle closure suspects were enrolled. Intraocular pressure, refraction, ocular biometry (Lenstar, LS900), and anterior chamber parameters (Pentacam HR) were measured at four occasions: before PI (before and after mydriasis with phenylephrine) and two weeks after PI (before and after mydriasis). The study was conducted on both eyes and only one eye per patient, in random, was included in the analysis. The mean age of the participants was 60±7 years and 17 (81%) were female. There were no significant differences in intraocular pressure, refraction, keratometry, biometric and anterior chamber parameters between groups, except for anterior chamber volume, which showed increments with PI and mydriasis. The corresponding values for anterior chamber volume were as follows: 88.2±13.7mm(3) before PI, undilated; 106.3±18.8 before PI, dilated; 99.0±14.6 after PI, undilated, and 107.4±16.5 after PI, dilated (P<0.001). This study showed no change in the ocular biometric and anterior chamber parameters including iridocorneal angle after PI and/or pharmacologic mydriasis except for increments in anterior chamber volume. This factor has the potential to be used as a numerical proxy for iris position in evaluating and monitoring patients with primary angle closure suspects after PI. Copyright © 2016 Spanish General Council of Optometry. Published by Elsevier Espana. All rights reserved.

Tumor heterogeneity measured on F-18 fluorodeoxyglucose positron emission tomography/computed tomography combined with plasma Epstein-Barr Virus load predicts prognosis in patients with primary nasopharyngeal carcinoma.

PubMed

Chan, Sheng-Chieh; Chang, Kai-Ping; Fang, Yu-Hua Dean; Tsang, Ngan-Ming; Ng, Shu-Hang; Hsu, Cheng-Lung; Liao, Chun-Ta; Yen, Tzu-Chen

2017-01-01

Plasma Epstein-Barr virus (EBV) DNA concentrations predict prognosis in patients with nasopharyngeal carcinoma (NPC). Recent evidence also indicates that intratumor heterogeneity on F-18 fluorodeoxyglucose positron emission tomography ( 18 F-FDG PET) scans is predictive of treatment outcomes in different solid malignancies. Here, we sought to investigate the prognostic value of heterogeneity parameters in patients with primary NPC. Retrospective cohort study. We examined 101 patients with primary NPC who underwent pretreatment 18 F-FDG PET/computed tomography. Circulating levels of EBV DNA were measured in all participants. The following PET heterogeneity parameters were collected: histogram-based heterogeneity parameters, second-order texture features (uniformity, contrast, entropy, homogeneity, dissimilarity, inverse difference moment), and higher-order (coarseness, contrast, busyness, complexity, strength) texture features. The median follow-up time was 5.14 years. Total lesion glycolysis (TLG), tumor heterogeneity measured by histogram-based parameter skewness, and the majority of second-order or higher-order texture features were significantly associated with overall survival (OS) and/or recurrence-free survival (RFS). In multivariate analysis, age (P =.005), EBV DNA load (P = .0002), and uniformity (P = .001) independently predicted OS. Only skewness retained the independent prognostic significance for RFS. Tumor stage, standardized uptake value, or TLG did not show an independent association with survival endpoints. The combination of uniformity, EBV DNA load, and age resulted in a more reliable prognostic stratification (P < .001). Tumor heterogeneity is superior to traditional PET parameters for predicting outcomes in primary NPC. The combination of uniformity with EBV DNA load can improve prognostic stratification in this clinical entity. 4 Laryngoscope, 127:E22-E28, 2017. © 2016 The American Laryngological, Rhinological and Otological Society, Inc.

Satellite Galaxies in the Illustris-1 Simulation: Poor Tracers of the Underlying Mass Distribution

NASA Astrophysics Data System (ADS)

Brainerd, Tereasa G.

2018-06-01

The 3-d spatial distribution of luminous satellite galaxies in the z=0 snapshot of the Illustris-1 simulation is compared to the 3-d spatial distribution of the mass surrounding the primary galaxies about which the satellites orbit. The primary-satellite sample is selected in such a way that it matches the selection criteria used in a previous study of luminous satellite galaxies in the Millennium Run simulation. A key difference between the two simulations is that luminous galaxies in the Millennium Run are the result of a semi-analytic galaxy formation model, while in Illustris-1 the luminous galaxies are the result of numerical hydrodynamics, star formation and feedback models. The sample consists of 1,025 primary galaxies with absolute magnitudes Mr < -20.5, and there are a total of 4,546 satellites with absolute magnitudes Mr < -14.5 within the virial radii of the primary galaxies. The mass distribution surrounding the primary galaxies is well fitted by an NFW profile with a concentration parameter c = 11.9. Contrary to a previous study using satellite galaxies in the Millennium Run, the number density profile of the full satellite sample from Illustris-1 is not at all well-fitted by an NFW profile. In the case of the faintest satellites (Mr > -17), the satellite number density profile is well-fitted by an NFW profile, but the concentration parameter is exceptionally low (c = 1.8) compared to the concentration parameter of the mass surrounding the primary galaxies. The conclusion from this work is that luminous satellite galaxies in Illustris-1 are poor tracers of the mass distribution surrounding their primary galaxies.

The impact of transmural multiprofessional simulation-based obstetric team training on perinatal outcome and quality of care in the Netherlands

PubMed Central

2014-01-01

Background Perinatal mortality and morbidity in the Netherlands is relatively high compared to other European countries. Our country has a unique system with an independent primary care providing care to low-risk pregnancies and a secondary/tertiary care responsible for high-risk pregnancies. About 65% of pregnant women in the Netherlands will be referred from primary to secondary care implicating multiple medical handovers. Dutch audits concluded that in the entire obstetric collaborative network process parameters could be improved. Studies have shown that obstetric team training improves perinatal outcome and that simulation-based obstetric team training implementing crew resource management (CRM) improves team performance. In addition, deliberate practice (DP) improves medical skills. The aim of this study is to analyse whether transmural multiprofessional simulation-based obstetric team training improves perinatal outcome. Methods/Design The study will be implemented in the south-eastern part of the Netherlands with an annual delivery rate of over 9,000. In this area secondary care is provided by four hospitals. Each hospital with referring primary care practices will form a cluster (study group). Within each cluster, teams will be formed of different care providers representing the obstetric collaborative network. CRM and elements of DP will be implemented in the training. To analyse the quality of care as perceived by patients, the Pregnancy and Childbirth Questionnaire (PCQ) will be used. Furthermore, self-reported collaboration between care providers will be assessed. Team performance will be measured by the Clinical Teamwork Scale (CTS). We employ a stepped-wedge trial design with a sequential roll-out of the trainings for the different study groups. Primary outcome will be perinatal mortality and/or admission to a NICU. Secondary outcome will be team performance, quality of care as perceived by patients, and collaboration among care providers. Conclusion The effect of transmural multiprofessional simulation-based obstetric team training on perinatal outcome has never been studied. We hypothesise that this training will improve perinatal outcome, team performance, and quality of care as perceived by patients and care providers. Trial registration The Netherlands National Trial Register, http://www.trialregister.nl/NTR4576, registered June 1, 2014 PMID:25145317

Measuring the apparent diffusion coefficient in primary rectal tumors: is there a benefit in performing histogram analyses?

PubMed

van Heeswijk, Miriam M; Lambregts, Doenja M J; Maas, Monique; Lahaye, Max J; Ayas, Z; Slenter, Jos M G M; Beets, Geerard L; Bakers, Frans C H; Beets-Tan, Regina G H

2017-06-01

The apparent diffusion coefficient (ADC) is a potential prognostic imaging marker in rectal cancer. Typically, mean ADC values are used, derived from precise manual whole-volume tumor delineations by experts. The aim was first to explore whether non-precise circular delineation combined with histogram analysis can be a less cumbersome alternative to acquire similar ADC measurements and second to explore whether histogram analyses provide additional prognostic information. Thirty-seven patients who underwent a primary staging MRI including diffusion-weighted imaging (DWI; b0, 25, 50, 100, 500, 1000; 1.5 T) were included. Volumes-of-interest (VOIs) were drawn on b1000-DWI: (a) precise delineation, manually tracing tumor boundaries (2 expert readers), and (b) non-precise delineation, drawing circular VOIs with a wide margin around the tumor (2 non-experts). Mean ADC and histogram metrics (mean, min, max, median, SD, skewness, kurtosis, 5th-95th percentiles) were derived from the VOIs and delineation time was recorded. Measurements were compared between the two methods and correlated with prognostic outcome parameters. Median delineation time reduced from 47-165 s (precise) to 21-43 s (non-precise). The 45th percentile of the non-precise delineation showed the best correlation with the mean ADC from the precise delineation as the reference standard (ICC 0.71-0.75). None of the mean ADC or histogram parameters showed significant prognostic value; only the total tumor volume (VOI) was significantly larger in patients with positive clinical N stage and mesorectal fascia involvement. When performing non-precise tumor delineation, histogram analysis (in specific 45th ADC percentile) may be used as an alternative to obtain similar ADC values as with precise whole tumor delineation. Histogram analyses are not beneficial to obtain additional prognostic information.

Advanced film-forming gel formula vs spring thermal water and white petrolatum as primary dressings after full-face ablative fractional CO2 laser resurfacing: a comparative split-face pilot study.

PubMed

Marini, L

2018-01-01

Aesthetically pleasing results and fast, uneventful recovery are highly desirable after rejuvenating ablative laser procedures. Wound dressings following ablative laser procedures should ideally improve and optimize the wound healing environment. The purpose of this comparative split-face, single-blinded, prospective observational study was to assess the efficacy and acceptability of two primary wound dressings immediately after a full-face fractional CO 2 laser resurfacing procedure. The assessments of an innovative film-forming dressing called Stratacel (SC) vs spring thermal water + Vaseline (V+) were conducted after a standardized, single-pass, full-face ablative fractional CO 2 laser skin resurfacing procedure. Clinical parameters, such as haemoglobin - HB; surface temperature - ST; micro-textural modifications - MT; superficial melanin - M; intrafollicular porphyrins - P, were assessed at different phases of the healing process using standardized, non-invasive technologies. Five female volunteers were enrolled in this inpatient, controlled pilot study. Most of the clinical parameters considered, including 3D surface texture analysis, revealed a better performance of SC vs. V+ during the early, more delicate phases of the healing process. This preliminary study, even if performed on a small number of volunteers, confirmed a definite advantage of the tested semipermeable film-forming formula (SC) over a more conventional postoperative skin care regime (V+). Clinical results could be explained by a better uniformity of distribution of SC over the micro-irregularities induced by ablative fractional CO 2 laser resurfacing. Its thin, semipermeable film might, in fact, act as an efficient, perfectly biocompatible, full contact, temporary skin barrier, able to protect extremely delicate healing surfaces from potential environmental irritations. © 2017 European Academy of Dermatology and Venereology.

Assessment of Wind Parameter Sensitivity on Ultimate and Fatigue Wind Turbine Loads: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Robertson, Amy N; Sethuraman, Latha; Jonkman, Jason

Wind turbines are designed using a set of simulations to ascertain the structural loads that the turbine could encounter. While mean hub-height wind speed is considered to vary, other wind parameters such as turbulence spectra, sheer, veer, spatial coherence, and component correlation are fixed or conditional values that, in reality, could have different characteristics at different sites and have a significant effect on the resulting loads. This paper therefore seeks to assess the sensitivity of different wind parameters on the resulting ultimate and fatigue loads on the turbine during normal operational conditions. Eighteen different wind parameters are screened using anmore » Elementary Effects approach with radial points. As expected, the results show a high sensitivity of the loads to the turbulence standard deviation in the primary wind direction, but the sensitivity to wind shear is often much greater. To a lesser extent, other wind parameters that drive loads include the coherence in the primary wind direction and veer.« less

Assessment of Wind Parameter Sensitivity on Extreme and Fatigue Wind Turbine Loads

DOE Office of Scientific and Technical Information (OSTI.GOV)

Robertson, Amy N; Sethuraman, Latha; Jonkman, Jason

Wind turbines are designed using a set of simulations to ascertain the structural loads that the turbine could encounter. While mean hub-height wind speed is considered to vary, other wind parameters such as turbulence spectra, sheer, veer, spatial coherence, and component correlation are fixed or conditional values that, in reality, could have different characteristics at different sites and have a significant effect on the resulting loads. This paper therefore seeks to assess the sensitivity of different wind parameters on the resulting ultimate and fatigue loads on the turbine during normal operational conditions. Eighteen different wind parameters are screened using anmore » Elementary Effects approach with radial points. As expected, the results show a high sensitivity of the loads to the turbulence standard deviation in the primary wind direction, but the sensitivity to wind shear is often much greater. To a lesser extent, other wind parameters that drive loads include the coherence in the primary wind direction and veer.« less

Influence of primary fragment excitation energy and spin distributions on fission observables

NASA Astrophysics Data System (ADS)

Litaize, Olivier; Thulliez, Loïc; Serot, Olivier; Chebboubi, Abdelaziz; Tamagno, Pierre

2018-03-01

Fission observables in the case of 252Cf(sf) are investigated by exploring several models involved in the excitation energy sharing and spin-parity assignment between primary fission fragments. In a first step the parameters used in the FIFRELIN Monte Carlo code "reference route" are presented: two parameters for the mass dependent temperature ratio law and two constant spin cut-off parameters for light and heavy fragment groups respectively. These parameters determine the initial fragment entry zone in excitation energy and spin-parity (E*, Jπ). They are chosen to reproduce the light and heavy average prompt neutron multiplicities. When these target observables are achieved all other fission observables can be predicted. We show here the influence of input parameters on the saw-tooth curve and we discuss the influence of a mass and energy-dependent spin cut-off model on gamma-rays related fission observables. The part of the model involving level densities, neutron transmission coefficients or photon strength functions remains unchanged.

IPMP Global Fit - A one-step direct data analysis tool for predictive microbiology.

PubMed

Huang, Lihan

2017-12-04

The objective of this work is to develop and validate a unified optimization algorithm for performing one-step global regression analysis of isothermal growth and survival curves for determination of kinetic parameters in predictive microbiology. The algorithm is incorporated with user-friendly graphical interfaces (GUIs) to develop a data analysis tool, the USDA IPMP-Global Fit. The GUIs are designed to guide the users to easily navigate through the data analysis process and properly select the initial parameters for different combinations of mathematical models. The software is developed for one-step kinetic analysis to directly construct tertiary models by minimizing the global error between the experimental observations and mathematical models. The current version of the software is specifically designed for constructing tertiary models with time and temperature as the independent model parameters in the package. The software is tested with a total of 9 different combinations of primary and secondary models for growth and survival of various microorganisms. The results of data analysis show that this software provides accurate estimates of kinetic parameters. In addition, it can be used to improve the experimental design and data collection for more accurate estimation of kinetic parameters. IPMP-Global Fit can be used in combination with the regular USDA-IPMP for solving the inverse problems and developing tertiary models in predictive microbiology. Published by Elsevier B.V.

Effects of Process Parameters on Solidification Structure of A390 Aluminum Alloy Hollow Billet

NASA Astrophysics Data System (ADS)

Zuo, Kesheng; Zhang, Haitao; Qin, Ke; Cui, Jianzhong; Chen, Qingzhang

2017-08-01

The effects of process parameters on the solidification structure of A390 aluminum alloy hollow billets prepared by direct-chill casting were investigated. The decrease of casting temperature deteriorated the homogeneity and increased the size of primary Si particles in the hollow billet. Although the average size of primary Si particles was not obviously affected by the increase of casting speed, the thickness of Si-depleted layer at the inner wall increased with the higher casting speed. The tensile strength of A390 alloy is a function of the percentage of coarse Si particles (larger than 35 μm) and the average size of primary Si particles. Higher and more stable tensile strength can be received in the hollow billet with the casting temperature of 1050 K (777 °C), because the fine and uniformly distributed primary Si particles were obtained in the hollow billet.

Inference of Surface Parameters from Near-Infrared Spectra of Crystalline H2O Ice with Neural Learning

NASA Astrophysics Data System (ADS)

Zhang, Lili; Merényi, Erzsébet; Grundy, William M.; Young, Eliot F.

2010-07-01

The near-infrared spectra of icy volatiles collected from planetary surfaces can be used to infer surface parameters, which in turn may depend on the recent geologic history. The high dimensionality and complexity of the spectral data, the subtle differences between the spectra, and the highly nonlinear interplay between surface parameters make it often difficult to accurately derive these surface parameters. We use a neural machine, with a Self-Organizing Map (SOM) as its hidden layer, to infer the latent physical parameters, temperature and grain size from near-infrared spectra of crystalline H2O ice. The output layer of the SOM-hybrid machine is customarily trained with only the output from the SOM winner. We show that this scheme prevents simultaneous achievement of high prediction accuracies for both parameters. We propose an innovative neural architecture we call Conjoined Twins that allows multiple (k) SOM winners to participate in the training of the output layer and in which the customization of k can be limited automatically to a small range. With this novel machine we achieve scientifically useful accuracies, 83.0 ± 2.7% and 100.0 ± 0.0%, for temperature and grain size, respectively, from simulated noiseless spectra. We also show that the performance of the neural model is robust under various noisy conditions. A primary application of this prediction capability is planned for spectra returned from the Pluto-Charon system by New Horizons.

Relationship between primary lesion metabolic parameters and clinical stage in lung cancer.

PubMed

Sahiner, I; Atasever, T; Akdemir, U O; Ozturk, C; Memis, L

2013-01-01

The relation of PET-derived parameters as maximum standardized uptake value (SUVmax), total lesion glycolysis (TLG), metabolic tumor volume (MTV) with clinical stage in lung cancer and correlation of SUVmax of primary tumor and that of metastatic lesion was studied in lung cancer patients. Patients with lung cancer who were referred for FDG PET/CT were included in the study. PET/CT scans and pathology reports of 168 patients were assessed. A total of 146 (86.9%) of these patients had a diagnosis of non-small cell lung cancer (NSCLC) and 22 (13.1%) had small cell lung cancer (SCLC). Metabolic parameters such as SUVmax, TLG and MTV showed significant differences in all the stages in NSCLC patients (p<0.001). However, after tumors sizes <25 mm were excluded, no significant differences in SUVmax between stages were observed. No significant differences were found between these metabolic parameters and limited or extended disease SCLC. Tumor diameter correlated with primary tumor SUVmax and significant correlations between primary lesion SUVmax and metastatic lesion SUVmax were found. Although differences were found regarding indices between stages of NSCLC cases, SUVmax differences between stages seem to be caused by underestimation of SUVmax in small lesions. Other glucose metabolism indexes such as MTV and TLG show promising results in terms of prognostic stratification. Future studies are needed for better understanding of their contribution to clinical cases. Copyright © 2013 Elsevier España, S.L. and SEMNIM. All rights reserved.

Incidence and clinical vital parameters in primary ketosis of Murrah buffaloes

PubMed Central

Kumar, Ankit; Sindhu, Neelesh; Kumar, Parmod; Kumar, Tarun; Charaya, Gaurav; Surbhi; Jain, V. K.; Sridhar

2015-01-01

Aim: The present study was undertaken to ascertain the incidence and clinical vital parameters in cases of primary ketosis in Murrah buffaloes brought to teaching veterinary clinical complex, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar and from adjoining villages of the district Hisar, Haryana, India. Materials and Methods: The investigation was conducted on 24 clinical cases (out of total 145 screened) of primary ketosis. The diagnosis was confirmed on the basis of clinical signs and significantly positive two tests for ketone bodies in urine (Rothera’s and Keto-Diastix strip test). Data collected were statistically analyzed using independent Student’s t-test. Results: Overall incidence of disease in these areas was found to be 16.55% and all the animals were recently parturited (mean: 1.42±0.14 month), on an average in their third lactation (mean: 2.38±0.30) and exhibited clinical signs such as selective anorexia (refusal to feed on concentrate diet), drastic reduction in milk yield (mean: 64.4±5.35%), ketotic odor from urine, breath, and milk and rapid loss of body condition. All the clinical vital parameters in ketotic buffaloes (body temperature, heart rate, respiration rate, and rumen movements) were within normal range. Conclusion: Primary ketosis in Murrah buffaloes was the most common seen in the third lactation, within the first 2 months after parturition with characteristics clinical signs and no variability in vital parameters. The disease has severe effect on the production status of affected animal. PMID:27047203

Finite Element Method (FEM) Modeling of Freeze-drying: Monitoring Pharmaceutical Product Robustness During Lyophilization.

PubMed

Chen, Xiaodong; Sadineni, Vikram; Maity, Mita; Quan, Yong; Enterline, Matthew; Mantri, Rao V

2015-12-01

Lyophilization is an approach commonly undertaken to formulate drugs that are unstable to be commercialized as ready to use (RTU) solutions. One of the important aspects of commercializing a lyophilized product is to transfer the process parameters that are developed in lab scale lyophilizer to commercial scale without a loss in product quality. This process is often accomplished by costly engineering runs or through an iterative process at the commercial scale. Here, we are highlighting a combination of computational and experimental approach to predict commercial process parameters for the primary drying phase of lyophilization. Heat and mass transfer coefficients are determined experimentally either by manometric temperature measurement (MTM) or sublimation tests and used as inputs for the finite element model (FEM)-based software called PASSAGE, which computes various primary drying parameters such as primary drying time and product temperature. The heat and mass transfer coefficients will vary at different lyophilization scales; hence, we present an approach to use appropriate factors while scaling-up from lab scale to commercial scale. As a result, one can predict commercial scale primary drying time based on these parameters. Additionally, the model-based approach presented in this study provides a process to monitor pharmaceutical product robustness and accidental process deviations during Lyophilization to support commercial supply chain continuity. The approach presented here provides a robust lyophilization scale-up strategy; and because of the simple and minimalistic approach, it will also be less capital intensive path with minimal use of expensive drug substance/active material.

Digital terrain modeling

NASA Astrophysics Data System (ADS)

Wilson, John P.

2012-01-01

This article examines how the methods and data sources used to generate DEMs and calculate land surface parameters have changed over the past 25 years. The primary goal is to describe the state-of-the-art for a typical digital terrain modeling workflow that starts with data capture, continues with data preprocessing and DEM generation, and concludes with the calculation of one or more primary and secondary land surface parameters. The article first describes some of ways in which LiDAR and RADAR remote sensing technologies have transformed the sources and methods for capturing elevation data. It next discusses the need for and various methods that are currently used to preprocess DEMs along with some of the challenges that confront those who tackle these tasks. The bulk of the article describes some of the subtleties involved in calculating the primary land surface parameters that are derived directly from DEMs without additional inputs and the two sets of secondary land surface parameters that are commonly used to model solar radiation and the accompanying interactions between the land surface and the atmosphere on the one hand and water flow and related surface processes on the other. It concludes with a discussion of the various kinds of errors that are embedded in DEMs, how these may be propagated and carried forward in calculating various land surface parameters, and the consequences of this state-of-affairs for the modern terrain analyst.

Concept Design of Trailor Ferry Service to Carry 150 Trailers Between Jacksonville, FL and Bridgeport, CT of USA

NASA Astrophysics Data System (ADS)

Sindagi, S. C.; Sandhu, B. S.

2015-04-01

With the increased load on highways, today there is a need to develop alternate ways to transport goods within the sovereignty. The use of ships to transport goods has always been the primary method of transporting goods across the seas but it can also be used to transport goods within the country. This way we can reduce the load on highways which at this point of time serve as the primary method of transportation. Worldwide very few ferries are in operation which transports 100-150 Trailers between two ports. Catching on this opportunity for design, construction and operation of vessels, a survey for possible routes in United States of America which will transport 150 Trailers has been conducted by various authorities and organizations. The challenge here is to determine the parameters of the vessel and design a fleet of vessels that could carry trailers along with their tractors within the least possible time and in with least possible freight between Jacksonville, FL and Bridgeport, CT of United States of America. The primary aim of the work presented here is to propose a design with fleet in such a way that each day 150 trailers could be loaded and unloaded at each of the two mentioned ports. An analysis of the route between the ports brought out various primary parameters like the distance, weather, different load lines to be encountered and also several size constraints that the vessel needs to adhere to, in order to ply smoothly on this route. The vessel is designed as per the Guidelines for ships operating in international waters. The economic analysis of the project was performed spanning over 20 years and the best freight was found out which would be most profitable for the company as well as be a good value for money for the customers.

Ross operation: 16-year experience.

PubMed

Elkins, Ronald C; Thompson, David M; Lane, Mary M; Elkins, C Craig; Peyton, Marvin D

2008-09-01

We performed a review of a consecutive series of 487 patients undergoing the Ross operation to identify surgical techniques and clinical parameters that affect outcome. We performed a prospective review of consecutive patients from August 1986 through June 2002 and follow-up through August 2004. Patient age was 2 days to 62 years (median, 24 years), and 197 patients were less than 18 years of age. The Ross operation was performed as a scalloped subcoronary implant in 26 patients, an inclusion cylinder in 54 patients, root replacement in 392 patients, and root-Konno procedure in 15 patients. Clinical follow-up in 96% and echocardiographic evaluation in 77% were performed within 2 years of closure. Actuarial survival was 82% +/- 6% at 16 years, and hospital mortality was 3.9%. Freedom from autograft failure (autograft reoperation and valve-related death) was 74% +/- 5%. Male sex and primary diagnosis of aortic insufficiency (no prior aortic stenosis) were significantly associated with autograft failure by means of multivariate analysis. Freedom from autograft valve replacement was 80% +/- 5%. Freedom from endocarditis was 95% +/- 2%. One late thromboembolic episode occurred. Freedom from allograft reoperation or reintervention was 82% +/- 4%. Freedom from all valve-related events was 63% +/- 6%. In children survival was 84% +/- 8%, and freedom from autograft valve failure was 83% +/- 6%. The Ross operation provides excellent survival in adults and children willing to accept a risk of reoperation. Male sex and a primary diagnosis of aortic insufficiency had a negative effect on late results.

Human Hepatocyte Isolation: Does Portal Vein Embolization Affect the Outcome?

PubMed

Kluge, Martin; Reutzel-Selke, Anja; Napierala, Hendrik; Hillebrandt, Karl Herbert; Major, Rebeka Dalma; Struecker, Benjamin; Leder, Annekatrin; Siefert, Jeffrey; Tang, Peter; Lippert, Steffen; Sallmon, Hannes; Seehofer, Daniel; Pratschke, Johann; Sauer, Igor M; Raschzok, Nathanael

2016-01-01

Primary human hepatocytes are widely used for basic research, pharmaceutical testing, and therapeutic concepts in regenerative medicine. Human hepatocytes can be isolated from resected liver tissue. Preoperative portal vein embolization (PVE) is increasingly used to decrease the risk of delayed postoperative liver regeneration by induction of selective hypertrophy of the future remnant liver tissue. The aim of this study was to investigate the effect of PVE on the outcome of hepatocyte isolation. Primary human hepatocytes were isolated from liver tissue obtained from partial hepatectomies (n = 190) using the two-step collagenase perfusion technique followed by Percoll purification. Of these hepatectomies, 27 isolations (14.2%) were performed using liver tissue obtained from patients undergoing PVE before surgery. All isolations were characterized using parameters that had been described in the literature as relevant for the outcome of hepatocyte isolation. The isolation outcomes of the PVE and the non-PVE groups were then compared before and after Percoll purification. Metabolic parameters (transaminases, urea, albumin, and vascular endothelial growth factor secretion) were measured in the supernatant of cultured hepatocytes for more than 6 days (PVE: n = 4 and non-PVE: n = 3). The PVE and non-PVE groups were similar in regard to donor parameters (sex, age, and indication for surgery), isolation parameters (liver weight and cold ischemia time), and the quality of the liver tissue. The mean initial viable cell yield did not differ between the PVE and non-PVE groups (10.16 ± 2.03 × 10(6) cells/g vs. 9.70 ± 0.73 × 10(6) cells/g, p = 0.499). The initial viability was slightly better in the PVE group (77.8% ± 2.03% vs. 74.4% ± 1.06%). The mean viable cell yield (p = 0.819) and the mean viability (p = 0.141) after Percoll purification did not differ between the groups. PVE had no effect on enzyme leakage and metabolic activity of cultured hepatocytes. Although PVE leads to drastic metabolic alterations and changes in hepatic blood flow, embolized liver tissue is a suitable source for the isolation of primary human hepatocytes and is equivalent to untreated liver tissue in regard to cell yield and viability.

Fifteen years of continuous improvement of quality care of type 2 diabetes mellitus in primary care in Catalonia, Spain.

PubMed

Mata-Cases, M; Roura-Olmeda, P; Berengué-Iglesias, M; Birulés-Pons, M; Mundet-Tuduri, X; Franch-Nadal, J; Benito-Badorrey, B; Cano-Pérez, J F

2012-03-01

To assess the evolution of type 2 diabetes mellitus (T2DM) quality indicators in primary care centers (PCC) as part of the Group for the Study of Diabetes in Primary Care (GEDAPS) Continuous Quality Improvement (GCQI) programme in Catalonia. Sequential cross-sectional studies were performed during 1993-2007. Process and outcome indicators in random samples of patients from each centre were collected. The results of each evaluation were returned to each centre to encourage the implementation of correcting interventions. Sixty-four different educational activities were performed during the study period with the participation of 2041 professionals. Clinical records of 23,501 patients were evaluated. A significant improvement was observed in the determination of some annual process indicators: HbA(1c) (51.7% vs. 88.9%); total cholesterol (75.9% vs. 90.9%); albuminuria screening (33.9% vs. 59.4%) and foot examination (48.9% vs. 64.2%). The intermediate outcome indicators also showed significant improvements: glycemic control [HbA(1c) ≤ 7% (< 57 mmol/mol); (41.5% vs. 64.2%)]; total cholesterol [≤ 200 mg/dl (5.17 mmol/l); (25.5% vs. 65.6%)]; blood pressure [≤ 140/90 mmHg; (45.4% vs. 66.1%)]. In addition, a significant improvement in some final outcome indicators such as prevalence of foot ulcers (7.6% vs. 2.6%); amputations (1.9% vs. 0.6%) and retinopathy (18.8% vs. 8.6%) was observed. Although those changes should not be strictly attributed to the GCQI programme, significant improvements in some process indicators, parameters of control and complications were observed in a network of primary care centres in Catalonia. © 2012 Blackwell Publishing Ltd.

Fifteen years of continuous improvement of quality care of type 2 diabetes mellitus in primary care in Catalonia, Spain

PubMed Central

Mata-Cases, M; Roura-Olmeda, P; Berengué-Iglesias, M; Birulés-Pons, M; Mundet-Tuduri, X; Franch-Nadal, J; Benito-Badorrey, B; Cano-Pérez, J F

2012-01-01

Aims To assess the evolution of type 2 diabetes mellitus (T2DM) quality indicators in primary care centers (PCC) as part of the Group for the Study of Diabetes in Primary Care (GEDAPS) Continuous Quality Improvement (GCQI) programme in Catalonia. Methods Sequential cross-sectional studies were performed during 1993–2007. Process and outcome indicators in random samples of patients from each centre were collected. The results of each evaluation were returned to each centre to encourage the implementation of correcting interventions. Sixty-four different educational activities were performed during the study period with the participation of 2041 professionals. Results Clinical records of 23,501 patients were evaluated. A significant improvement was observed in the determination of some annual process indicators: HbA1c (51.7% vs. 88.9%); total cholesterol (75.9% vs. 90.9%); albuminuria screening (33.9% vs. 59.4%) and foot examination (48.9% vs. 64.2%). The intermediate outcome indicators also showed significant improvements: glycemic control [HbA1c ≤ 7% (< 57 mmol/mol); (41.5% vs. 64.2%)]; total cholesterol [≤ 200 mg/dl (5.17 mmol/l); (25.5% vs. 65.6%)]; blood pressure [≤ 140/90 mmHg; (45.4% vs. 66.1%)]. In addition, a significant improvement in some final outcome indicators such as prevalence of foot ulcers (7.6% vs. 2.6%); amputations (1.9% vs. 0.6%) and retinopathy (18.8% vs. 8.6%) was observed. Conclusions Although those changes should not be strictly attributed to the GCQI programme, significant improvements in some process indicators, parameters of control and complications were observed in a network of primary care centres in Catalonia. PMID:22340449

Adsorptive removal of pharmaceuticals from water by commercial and waste-based carbons.

PubMed

Calisto, Vânia; Ferreira, Catarina I A; Oliveira, João A B P; Otero, Marta; Esteves, Valdemar I

2015-04-01

This work describes the single adsorption of seven pharmaceuticals (carbamazepine, oxazepam, sulfamethoxazole, piroxicam, cetirizine, venlafaxine and paroxetine) from water onto a commercially available activated carbon and a non-activated carbon produced by pyrolysis of primary paper mill sludge. Kinetics and equilibrium adsorption studies were performed using a batch experimental approach. For all pharmaceuticals, both carbons presented fast kinetics (equilibrium times varying from less than 5 min to 120 min), mainly described by a pseudo-second order model. Equilibrium data were appropriately described by the Langmuir and Freundlich isotherm models, the last one giving slightly higher correlation coefficients. The fitted parameters obtained for both models were quite different for the seven pharmaceuticals under study. In order to evaluate the influence of water solubility, log Kow, pKa, polar surface area and number of hydrogen bond acceptors of pharmaceuticals on the adsorption parameters, multiple linear regression analysis was performed. The variability is mainly due to log Kow followed by water solubility, in the case of the waste-based carbon, and due to water solubility in the case of the commercial activated carbon. Copyright © 2015 Elsevier Ltd. All rights reserved.

Systematic review on strength training in Parkinson’s disease: an unsolved question

PubMed Central

Ramazzina, Ileana; Bernazzoli, Benedetta; Costantino, Cosimo

2017-01-01

The purpose of this study was to investigate the effectiveness of strength training, performed against a different resistance from body weight, in improving motor and nonmotor symptoms in patients with Parkinson’s disease (PD). The following electronic databases were searched: PubMed, Physiotherapy Evidence Database, Cochrane Central Register of Controlled Trials, Scopus, and Web of Science. The review was conducted and reported in accordance with the PRISMA statement. Thirteen high-quality randomized controlled trials were included. Strength training performed against external resistance is well tolerated and appears to be a suitable physical activity to improve both physical parameters and quality of life parameters of PD subjects. However, although the study intervention included strength training, only a few selected studies assessed the improvement of muscle strength. Despite the encouraging results, it is difficult to establish a correlation between strength training and the improvements made. Our review highlights the lack of common intent in terms of study design and the presence of different primary and secondary outcomes. Accordingly, further studies are needed to support the beneficial effects of different types of strength training in PD subjects and to underline the superiority of strength training in PD patients with respect to other training. PMID:28408811

Physiologically based pharmacokinetic modeling of dibromoacetic acid in F344 rats

PubMed Central

Matthews, Jessica L.; Schultz, Irvin R.; Easterling, Michael R.; Melnick, Ronald L.

2010-01-01

A novel physiologically based pharmacokinetic (PBPK) model structure, which includes submodels for the common metabolites (glyoxylate (GXA) and oxalate (OXA)) that may be involved in the toxicity or carcinogenicity of dibromoacetic acid (DBA), has been developed. Particular attention is paid to the representation of hepatic metabolism, which is the primary elimination mechanism. DBA-induced suicide inhibition is modeled by irreversible covalent binding of the intermediate metabolite α-halocarboxymethylglutathione (αH1) to the glutathione-S-transferase zeta (GSTzeta) enzyme. We also present data illustrating the presence of a secondary non-GSTzeta metabolic pathway for DBA, but not dichloroacetic acid (DCA), that produces GXA. The model is calibrated with plasma and urine concentration data from DBA exposures in female F344 rats through intravenous (IV), oral gavage, and drinking water routes. Sensitivity analysis is performed to confirm identifiability of estimated parameters. Finally, model validation is performed with data sets not used during calibration. Given the structural similarity of dihaloacetates (DHAs), we hypothesize that the PBPK model presented here has the capacity to describe the kinetics of any member or mixture of members of this class in any species with the alteration of chemical- and species-specific parameters. PMID:20045428

Evaluation of advanced displays for engine monitoring and control

NASA Technical Reports Server (NTRS)

Summers, L. G.

1993-01-01

The relative effectiveness of two advanced display concepts for monitoring engine performance for commercial transport aircraft was studied. The concepts were the Engine Monitoring and Control System (EMACS) display developed by NASA Langley and a display by exception design. Both of these concepts were based on the philosophy of providing information that is directly related to the pilot's task. Both concepts used a normalized thrust display. In addition, EMACS used column deviation indicators; i.e., the difference between the actual parameter value and the value predicted by an engine model, for engine health monitoring; while the Display by Exception displayed the engine parameters if the automated system detected a difference between the actual and the predicted values. The results showed that the advanced display concepts had shorter detection and response times. There were no differences in any of the results between manual and auto throttles. There were no effects upon perceived workload or performance on the primary flight task. The majority of pilots preferred the advanced displays and thought they were operationally acceptable. Certification of these concepts depends on the validation of the engine model. Recommendations are made to improve both the EMACS and the display by exception display formats.

TVA-based assessment of visual attentional functions in developmental dyslexia

PubMed Central

Bogon, Johanna; Finke, Kathrin; Stenneken, Prisca

2014-01-01

There is an ongoing debate whether an impairment of visual attentional functions constitutes an additional or even an isolated deficit of developmental dyslexia (DD). Especially performance in tasks that require the processing of multiple visual elements in parallel has been reported to be impaired in DD. We review studies that used parameter-based assessment for identifying and quantifying impaired aspect(s) of visual attention that underlie this multi-element processing deficit in DD. These studies used the mathematical framework provided by the “theory of visual attention” (Bundesen, 1990) to derive quantitative measures of general attentional resources and attentional weighting aspects on the basis of behavioral performance in whole- and partial-report tasks. Based on parameter estimates in children and adults with DD, the reviewed studies support a slowed perceptual processing speed as an underlying primary deficit in DD. Moreover, a reduction in visual short term memory storage capacity seems to present a modulating component, contributing to difficulties in written language processing. Furthermore, comparing the spatial distributions of attentional weights in children and adults suggests that having limited reading and writing skills might impair the development of a slight leftward bias, that is typical for unimpaired adult readers. PMID:25360129

Application of Taguchi Method for Analyzing Factors Affecting the Performance of Coated Carbide Tool When Turning FCD700 in Dry Cutting Condition

NASA Astrophysics Data System (ADS)

Ghani, Jaharah A.; Mohd Rodzi, Mohd Nor Azmi; Zaki Nuawi, Mohd; Othman, Kamal; Rahman, Mohd. Nizam Ab.; Haron, Che Hassan Che; Deros, Baba Md

2011-01-01

Machining is one of the most important manufacturing processes in these modern industries especially for finishing an automotive component after the primary manufacturing processes such as casting and forging. In this study the turning parameters of dry cutting environment (without air, normal air and chilled air), various cutting speed, and feed rate are evaluated using a Taguchi optimization methodology. An orthogonal array L27 (313), signal-to-noise (S/N) ratio and analysis of variance (ANOVA) are employed to analyze the effect of these turning parameters on the performance of a coated carbide tool. The results show that the tool life is affected by the cutting speed, feed rate and cutting environment with contribution of 38%, 32% and 27% respectively. Whereas for the surface roughness, the feed rate is significantly controlled the machined surface produced by 77%, followed by the cutting environment of 19%. The cutting speed is found insignificant in controlling the machined surface produced. The study shows that the dry cutting environment factor should be considered in order to produce longer tool life as well as for obtaining a good machined surface.

Assessment of impact of acoustic and nonacoustic parameters on performance and well-being

NASA Astrophysics Data System (ADS)

Mellert, Volker; Weber, Reinhard; Nocke, Christian

2004-05-01

It is of interest to estimate the influence of the environment in a specific work place area on the performance and well-being of people. Investigations have been carried out for the cabin environment of an airplane and for class rooms. Acoustics is only one issue of a variety of environmental factors, therefore the combined impact of temperature, humidity, air quality, lighting, vibration, etc. on human perception is the subject of psychophysical research. Methods for the objective assessment of subjective impressions have been developed for applications in acoustics for a long time, e.g., for concert hall acoustics, noise evaluation, and sound design. The methodology relies on questionnaires, measurement of acoustic parameters, ear-related signal processing and analysis, and on correlation of the physical input with subjective output. Methodology and results are presented from measurements of noise and vibration, temperature and humidity in aircraft simulators, and of reverberation, coloring, and lighting in a primary school, and of the environmental perception. [The work includes research with M. Klatte, A. Schick from the Psychology Department of Oldenburg University, and M. Meis from Hoerzentrum Oldenburg GmbH and with the European Project HEACE (for partners see www.heace.org).

Physiologically based pharmacokinetic modeling of dibromoacetic acid in F344 rats

DOE Office of Scientific and Technical Information (OSTI.GOV)

Matthews, Jessica L., E-mail: Jessica_Matthews@sra.co; Schultz, Irvin R., E-mail: irv.schultz@pnl.go; Easterling, Michael R., E-mail: Michael_Easterling@sra.co

A novel physiologically based pharmacokinetic (PBPK) model structure, which includes submodels for the common metabolites (glyoxylate (GXA) and oxalate (OXA)) that may be involved in the toxicity or carcinogenicity of dibromoacetic acid (DBA), has been developed. Particular attention is paid to the representation of hepatic metabolism, which is the primary elimination mechanism. DBA-induced suicide inhibition is modeled by irreversible covalent binding of the intermediate metabolite alpha-halocarboxymethylglutathione (alphaH1) to the glutathione-S-transferase zeta (GSTzeta) enzyme. We also present data illustrating the presence of a secondary non-GSTzeta metabolic pathway for DBA, but not dichloroacetic acid (DCA), that produces GXA. The model is calibratedmore » with plasma and urine concentration data from DBA exposures in female F344 rats through intravenous (IV), oral gavage, and drinking water routes. Sensitivity analysis is performed to confirm identifiability of estimated parameters. Finally, model validation is performed with data sets not used during calibration. Given the structural similarity of dihaloacetates (DHAs), we hypothesize that the PBPK model presented here has the capacity to describe the kinetics of any member or mixture of members of this class in any species with the alteration of chemical-and species-specific parameters.« less

The Productivity and Cost-Efficiency of Models for Involving Nurse Practitioners in Primary Care: A Perspective from Queueing Analysis

PubMed Central

Liu, Nan; D'Aunno, Thomas

2012-01-01

Objective To develop simple stylized models for evaluating the productivity and cost-efficiencies of different practice models to involve nurse practitioners (NPs) in primary care, and in particular to generate insights on what affects the performance of these models and how. Data Sources and Study Design The productivity of a practice model is defined as the maximum number of patients that can be accounted for by the model under a given timeliness-to-care requirement; cost-efficiency is measured by the corresponding annual cost per patient in that model. Appropriate queueing analysis is conducted to generate formulas and values for these two performance measures. Model parameters for the analysis are extracted from the previous literature and survey reports. Sensitivity analysis is conducted to investigate the model performance under different scenarios and to verify the robustness of findings. Principal Findings Employing an NP, whose salary is usually lower than a primary care physician, may not be cost-efficient, in particular when the NP's capacity is underutilized. Besides provider service rates, workload allocation among providers is one of the most important determinants for the cost-efficiency of a practice model involving NPs. Capacity pooling among providers could be a helpful strategy to improve efficiency in care delivery. Conclusions The productivity and cost-efficiency of a practice model depend heavily on how providers organize their work and a variety of other factors related to the practice environment. Queueing theory provides useful tools to take into account these factors in making strategic decisions on staffing and panel size selection for a practice model. PMID:22092009

Primary Care Performance Measurement and Reporting at a Regional Level: Could a Matrix Approach Provide Actionable Information for Policy Makers and Clinicians?

PubMed

Langton, Julia M; Wong, Sabrina T; Johnston, Sharon; Abelson, Julia; Ammi, Mehdi; Burge, Fred; Campbell, John; Haggerty, Jeannie; Hogg, William; Wodchis, Walter P; McGrail, Kimberlyn

2016-11-01

Primary care services form the foundation of modern healthcare systems, yet the breadth and complexity of services and diversity of patient populations may present challenges for creating comprehensive primary care information systems. Our objective is to develop regional-level information on the performance of primary care in Canada. A scoping review was conducted to identify existing initiatives in primary care performance measurement and reporting across 11 countries. The results of this review were used by our international team of primary care researchers and clinicians to propose an approach for regional-level primary care reporting. We found a gap between conceptual primary care performance measurement frameworks in the peer-reviewed literature and real-world primary care performance measurement and reporting activities. We did not find a conceptual framework or analytic approach that could readily form the foundation of a regional-level primary care information system. Therefore, we propose an approach to reporting comprehensive and actionable performance information according to widely accepted core domains of primary care as well as different patient population groups. An approach that bridges the gap between conceptual frameworks and real-world performance measurement and reporting initiatives could address some of the potential pitfalls of existing ways of presenting performance information (i.e., by single diseases or by age). This approach could produce meaningful and actionable information on the quality of primary care services. Copyright © 2016 Longwoods Publishing.

Primary Care Performance Measurement and Reporting at a Regional Level: Could a Matrix Approach Provide Actionable Information for Policy Makers and Clinicians?

PubMed Central

Langton, Julia M.; Wong, Sabrina T.; Johnston, Sharon; Abelson, Julia; Ammi, Mehdi; Burge, Fred; Campbell, John; Haggerty, Jeannie; Hogg, William; Wodchis, Walter P.

2016-01-01

Objective: Primary care services form the foundation of modern healthcare systems, yet the breadth and complexity of services and diversity of patient populations may present challenges for creating comprehensive primary care information systems. Our objective is to develop regional-level information on the performance of primary care in Canada. Methods: A scoping review was conducted to identify existing initiatives in primary care performance measurement and reporting across 11 countries. The results of this review were used by our international team of primary care researchers and clinicians to propose an approach for regional-level primary care reporting. Results: We found a gap between conceptual primary care performance measurement frameworks in the peer-reviewed literature and real-world primary care performance measurement and reporting activities. We did not find a conceptual framework or analytic approach that could readily form the foundation of a regional-level primary care information system. Therefore, we propose an approach to reporting comprehensive and actionable performance information according to widely accepted core domains of primary care as well as different patient population groups. Conclusions: An approach that bridges the gap between conceptual frameworks and real-world performance measurement and reporting initiatives could address some of the potential pitfalls of existing ways of presenting performance information (i.e., by single diseases or by age). This approach could produce meaningful and actionable information on the quality of primary care services. PMID:28032823

Arrhenius parameters for primary thermal injury in human tonsillar tissue

NASA Astrophysics Data System (ADS)

McMillan, Kathleen; Radabaugh, Rebecca; Coad, James E.

2011-03-01

Clinical implementation of a thermal therapy requires the ability to predict tissue injury following exposures to specific thermal histories. As part of an effort to develop a nonexcisional alternative to tonsillectomy, the degree of primary hyperthermic tissue injury in human tonsil was characterized. Fifteen fresh pediatric hypertrophic tonsillectomy specimens were sectioned and treated in a NIST-calibrated saline bath at temperatures of 40 to 70°C with hold times of one to seven minutes. The treated tissues were subsequently nitroblue tetrazolium (NBT) stained to assess for thermal respiratory enzyme inactivation as a marker of cellular injury/death. The NBT stains were quantitatively image analyzed and used to calculate Arrhenius parameters for primary thermal injury in human tonsils.

Fundamental limits of image registration performance: Effects of image noise and resolution in CT-guided interventions.

PubMed

Ketcha, M D; de Silva, T; Han, R; Uneri, A; Goerres, J; Jacobson, M; Vogt, S; Kleinszig, G; Siewerdsen, J H

2017-02-11

In image-guided procedures, image acquisition is often performed primarily for the task of geometrically registering information from another image dataset, rather than detection / visualization of a particular feature. While the ability to detect a particular feature in an image has been studied extensively with respect to image quality characteristics (noise, resolution) and is an ongoing, active area of research, comparatively little has been accomplished to relate such image quality characteristics to registration performance. To establish such a framework, we derived Cramer-Rao lower bounds (CRLB) for registration accuracy, revealing the underlying dependencies on image variance and gradient strength. The CRLB was analyzed as a function of image quality factors (in particular, dose) for various similarity metrics and compared to registration accuracy using CT images of an anthropomorphic head phantom at various simulated dose levels. Performance was evaluated in terms of root mean square error (RMSE) of the registration parameters. Analysis of the CRLB shows two primary dependencies: 1) noise variance (related to dose); and 2) sum of squared image gradients (related to spatial resolution and image content). Comparison of the measured RMSE to the CRLB showed that the best registration method, RMSE achieved the CRLB to within an efficiency factor of 0.21, and optimal estimators followed the predicted inverse proportionality between registration performance and radiation dose. Analysis of the CRLB for image registration is an important step toward understanding and evaluating an intraoperative imaging system with respect to a registration task. While the CRLB is optimistic in absolute performance, it reveals a basis for relating the performance of registration estimators as a function of noise content and may be used to guide acquisition parameter selection (e.g., dose) for purposes of intraoperative registration.

A study of root canal morphology of human primary incisors and molars using cone beam computerized tomography: an in vitro study.

PubMed

Gaurav, Vivek; Srivastava, Nikhil; Rana, Vivek; Adlakha, Vivek Kumar

2013-01-01

Variations in morphology of root canals in primary teeth usually leads to complications during and after endodontic therapy. To improve the success in endodontics, a thorough knowledge of the root canal morphology is essential. The aim of this study was to assess the variation in number and morphology of the root canals of primary incisors and molars and to study the applicability of cone beam computerized tomography (CBCT) in assessing the same. A total of 60 primary molars and incisors with full root length were collected and various parameters such as the number of roots, number of canals, diameter of root canal at cementoenamel junction and middle-third, length and angulations of roots of primary molars and incisors were studied using CBCT. The observations were put to descriptive statistics to find out the frequency, mean, standard deviation and range for all four subgroups. Further, unpaired t-test was used to compare these parameters between subgroups and analysis of variance test was implemented to evaluate the parameters within the subgroups. The CBCT showed the presence of bifurcation of root canal at middle third in 13% of mandibular incisors while 20% of mandibular molars had two canals in distal root. The diameter of distobuccal root canal of maxillary molars and mesiolingual canal of mandibular molars was found to be minimum. CBCT is a relatively new and effective technology, which provides an auxiliary imaging modality to supplement conventional radiography for assessing the variation in root canal morphology of primary teeth.

Numerical study of magnetohydrodynamic viscous plasma flow in rotating porous media with Hall currents and inclined magnetic field influence

NASA Astrophysics Data System (ADS)

Bég, O. Anwar; Sim, Lik; Zueco, J.; Bhargava, R.

2010-02-01

A numerical solution is developed for the viscous, incompressible, magnetohydrodynamic flow in a rotating channel comprising two infinite parallel plates and containing a Darcian porous medium, the plates lying in the x-z plane, under constant pressure gradient. The system is subjected to a strong, inclined magnetic field orientated to the positive direction of the y-axis (rotational axis, normal to the x-z plane). The Navier-Stokes flow equations for a general rotating hydromagnetic flow are reduced to a pair of linear, viscous partial differential equations neglecting convective acceleration terms, for primary velocity (u‧) and secondary velocity (v‧) where these velocities are directed along the x and y axes. Only viscous terms are retained in the momenta equations. The model is non-dimensionalized and shown to be controlled by a number of dimensionless parameters. The resulting dimensionless ordinary differential equations are solved using a robust numerical method, Network Simulation Methodology. Full details of the numerics are provided. The present solutions are also benchmarked against the analytical solutions presented recently by Ghosh and Pop [Ghosh SK, Pop I. An analytical approach to MHD plasma behaviour of a rotating environment in the presence of an inclined magnetic field as compared to excitation frequency. Int J Appl Mech Eng 2006;11(4):845-856] for the case of a purely fluid medium (infinite permeability). We study graphically the influence of Hartmann number (Ha, magnetic field parameter), Ekman number (Ek, rotation parameter), Hall current parameter (Nh), Darcy number (Da, permeability parameter), pressure gradient (Np) and also magnetic field inclination (θ) on primary and secondary velocity fields. Additionally we investigate the effects of these multiphysical parameters on the dimensionless shear stresses at the plates. Both primary and secondary velocity are seen to be increased with a rise in Darcy number, owing to a simultaneous reduction in Darcian drag force. Primary velocity is seen to decrease with an increase in Hall current parameter (Nh) but there is a decrease in secondary velocity. The study finds important applications in magnetic materials processing, hydromagnetic plasma energy generators, magneto-geophysics and planetary astrophysics.

Validation of a Visual-Spatial Secondary Task to Assess Automaticity in Laparoscopic Skills.

PubMed

Castillo, Richard; Alvarado, Juan; Moreno, Pablo; Billeke, Pablo; Martínez, Carlos; Varas, Julián; Jarufe, Nicolás

2017-12-26

Our objective was to assess reliability and validity of a visual-spatial secondary task (VSST) as a method to measure automaticity on a basic simulated laparoscopic skill model. In motor skill acquisition, expertise is defined by automaticity. The highest level of performance with less cognitive and attentional resources characterizes this stage, allowing experts to perform multiple tasks. Conventional validated parameters as operative time, objective assessment skills scales (OSATS), and movement economy, are insufficient to distinguish if an individual has reached the more advanced learning phases, such as automaticity. There is literature about using a VSST as an attention indicator that correlates with the automaticity level. Novices with completed and approved Fundamentals of Laparoscopic Surgery course, and laparoscopy experts were enrolled for an experimental study and measured under dual tasks conditions. Each participant performed the test giving priority to the primary task while at the same time they responded to a VSST. The primary task consisted of 4 interrupted laparoscopic stitches (ILS) on a bench-model. The VSST was a screen that showed different patterns that the surgeon had to recognize and press a pedal while doing the stitches (PsychoPsy software, Python, MacOS). Novices were overtrained on ILS until they reach at least 100 repetitions and then were retested. Participants were video recorded and then assessed by 2 blinded evaluators who measured operative time and OSATS. These scores were considered indicators of quality for the primary task. The VSST performance was measured by the detectability index (DI), which is a ratio between correct and wrong detections. A reliable evaluation was defined as two measures of DI with less than 10% of difference, maintaining the cutoff scores for performance on the primary task (operative time <110 seg and OSATS >17 points). Novices (n = 11) achieved reliable measure of the test after 2 (2-5) repetitions on the preassessment and 3.75 (2-5) on the postassessment (p = 0.04); whereas laparoscopy experts (n = 4) did it after 3.5 (3-4) repetitions. Proficiency cutoff scores for the primary task were achieved on every measure for novices (prepost overtraining) and experts. Expert performance on VSST was DI 0.78 (0.69-0.87). Novice performance was significantly better on postassessment (DI-pre 0.48 [0.06-0.71] vs DI-post 0.78 [0.48-0.95], p = 0.003). Overtraining consisted in 140 (100-210) repetitions of ILS for all novices, made in 8 hours (3-15). By categorizing DI based on expert performance, novices with DI-post >0.65 achieved better OSATS score and less operative time than novices with DI-post<0.65 (p = 0.007 y, p = 0.089, respectively). Measuring automaticity is feasible using a VSST. This instrument is reliable and has a face, content and construct validity. A DI over 0.65 may be a cutoff point correlated with high standard performance on the primary task. This instrument measures performance on laparoscopic skills, and along with conventional indicators, would better define advance levels of expertise. More studies are required applying this VSST to achieve external validity by reproducing our results. Copyright © 2017 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

Description and performance of track and primary-vertex reconstruction with the CMS tracker

DOE PAGES

Chatrchyan, Serguei

2014-10-16

A description is provided of the software algorithms developed for the CMS tracker both for reconstructing charged-particle trajectories in proton-proton interactions and for using the resulting tracks to estimate the positions of the LHC luminous region and individual primary-interaction vertices. Despite the very hostile environment at the LHC, the performance obtained with these algorithms is found to be excellent. For tbar t events under typical 2011 pileup conditions, the average track-reconstruction efficiency for promptly-produced charged particles with transverse momenta of p T > 0.9GeV is 94% for pseudorapidities of |η| < 0.9 and 85% for 0.9 < |η| < 2.5.more » The inefficiency is caused mainly by hadrons that undergo nuclear interactions in the tracker material. For isolated muons, the corresponding efficiencies are essentially 100%. For isolated muons of p T = 100GeV emitted at |η| < 1.4, the resolutions are approximately 2.8% in p T, and respectively, 10μm and 30μm in the transverse and longitudinal impact parameters. The position resolution achieved for reconstructed primary vertices that correspond to interesting pp collisions is 10–12μm in each of the three spatial dimensions. The tracking and vertexing software is fast and flexible, and easily adaptable to other functions, such as fast tracking for the trigger, or dedicated tracking for electrons that takes into account bremsstrahlung.« less

[Comparative study on the effect of antiatherosclerotic diet enriched with polyunsaturated omega-3 fatty acids of plant and animal origin on the level of natural antibodies against catecholamines in patients with cardiovascular diseases].

PubMed

Pogozheva, A V; Rozanova, I A; Miagkova, M A; Sorokovoĭ, K V; Panchenko, O N; Trubacheva, Zh N

1998-01-01

The levels of natural antibodies against catecholamines in 138 patients with cardiovascular diseases was studied and the comparative analysis of influence of antiatherosclerotic diets with different origin of PUFA omega-3 on dynamic of these parameters was made. For the first time discovered universal action of diets with PUFA omega-3 vegetable and animal origin on parameters of humoral immunity: in case of primary excess of norm of the contents of natural antibodies to adrenaline, noradrenaline and dopamine as a result of treatment these parameters were reduced or did not change; and at is primary a low their level--parameters increased in most cases. The greatest immunocorrection effect was rendered by diet, enriched PUFA omega-3 of freshwater fishes fat.

Age determination of female redhead ducks

USGS Publications Warehouse

Dane, C.W.; Johnson, D.H.

1975-01-01

Eighty-seven fall-collected wings from female redhead ducks (Aythya americana) were assigned to the adult or juvenile group based on 'tertial' and 'tertial covert' shape and wear. To obtain spring age-related characters from these fall-collected groupings, we considered parameters of flight feathers retained until after the first breeding season. Parameters measured included: markings on and width of greater secondary coverts, and length, weight, and diameter of primary feathers. The best age categorization was obtained with discriminant analysis based on a combination of the most accurately measured parameters. This analysis, applied to 81 wings with complete measurements, resulted in only 1 being incorrectly aged and 3 placed in a questionable category. Discriminant functions used with covert markings and the three 5th primary parameters were applied to 30 known-age juvenile, hand-reared redhead females, 28 were correctly aged, none was incorrectly aged, and only 2 were placed in the questionable category.

Crop physiology calibration in the CLM

DOE PAGES

Bilionis, I.; Drewniak, B. A.; Constantinescu, E. M.

2015-04-15

Farming is using more of the land surface, as population increases and agriculture is increasingly applied for non-nutritional purposes such as biofuel production. This agricultural expansion exerts an increasing impact on the terrestrial carbon cycle. In order to understand the impact of such processes, the Community Land Model (CLM) has been augmented with a CLM-Crop extension that simulates the development of three crop types: maize, soybean, and spring wheat. The CLM-Crop model is a complex system that relies on a suite of parametric inputs that govern plant growth under a given atmospheric forcing and available resources. CLM-Crop development used measurementsmore » of gross primary productivity (GPP) and net ecosystem exchange (NEE) from AmeriFlux sites to choose parameter values that optimize crop productivity in the model. In this paper, we calibrate these parameters for one crop type, soybean, in order to provide a faithful projection in terms of both plant development and net carbon exchange. Calibration is performed in a Bayesian framework by developing a scalable and adaptive scheme based on sequential Monte Carlo (SMC). The model showed significant improvement of crop productivity with the new calibrated parameters. We demonstrate that the calibrated parameters are applicable across alternative years and different sites.« less

Crop physiology calibration in the CLM

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bilionis, I.; Drewniak, B. A.; Constantinescu, E. M.

Farming is using more of the land surface, as population increases and agriculture is increasingly applied for non-nutritional purposes such as biofuel production. This agricultural expansion exerts an increasing impact on the terrestrial carbon cycle. In order to understand the impact of such processes, the Community Land Model (CLM) has been augmented with a CLM-Crop extension that simulates the development of three crop types: maize, soybean, and spring wheat. The CLM-Crop model is a complex system that relies on a suite of parametric inputs that govern plant growth under a given atmospheric forcing and available resources. CLM-Crop development used measurementsmore » of gross primary productivity (GPP) and net ecosystem exchange (NEE) from AmeriFlux sites to choose parameter values that optimize crop productivity in the model. In this paper, we calibrate these parameters for one crop type, soybean, in order to provide a faithful projection in terms of both plant development and net carbon exchange. Calibration is performed in a Bayesian framework by developing a scalable and adaptive scheme based on sequential Monte Carlo (SMC). The model showed significant improvement of crop productivity with the new calibrated parameters. We demonstrate that the calibrated parameters are applicable across alternative years and different sites.« less

Design of ceramic components with the NASA/CARES computer program

NASA Technical Reports Server (NTRS)

Nemeth, Noel N.; Manderscheid, Jane M.; Gyekenyesi, John P.

1990-01-01

The ceramics analysis and reliability evaluation of structures (CARES) computer program is described. The primary function of the code is to calculate the fast-fracture reliability or failure probability of macro-scopically isotropic ceramic components. These components may be subjected to complex thermomechanical loadings, such as those found in heat engine applications. CARES uses results from MSC/NASTRAN or ANSYS finite-element analysis programs to evaluate how inherent surface and/or volume type flaws component reliability. CARES utilizes the Batdorf model and the two-parameter Weibull cumulative distribution function to describe the effects of multiaxial stress states on material strength. The principle of independent action (PIA) and the Weibull normal stress averaging models are also included. Weibull material strength parameters, the Batdorf crack density coefficient, and other related statistical quantities are estimated from four-point bend bar or uniform uniaxial tensile specimen fracture strength data. Parameter estimation can be performed for a single or multiple failure modes by using a least-squares analysis or a maximum likelihood method. Kolmogorov-Smirnov and Anderson-Darling goodness-to-fit-tests, 90 percent confidence intervals on the Weibull parameters, and Kanofsky-Srinivasan 90 percent confidence band values are also provided. Examples are provided to illustrate the various features of CARES.

Objective consensus from decision trees.

PubMed

Putora, Paul Martin; Panje, Cedric M; Papachristofilou, Alexandros; Dal Pra, Alan; Hundsberger, Thomas; Plasswilm, Ludwig

2014-12-05

Consensus-based approaches provide an alternative to evidence-based decision making, especially in situations where high-level evidence is limited. Our aim was to demonstrate a novel source of information, objective consensus based on recommendations in decision tree format from multiple sources. Based on nine sample recommendations in decision tree format a representative analysis was performed. The most common (mode) recommendations for each eventuality (each permutation of parameters) were determined. The same procedure was applied to real clinical recommendations for primary radiotherapy for prostate cancer. Data was collected from 16 radiation oncology centres, converted into decision tree format and analyzed in order to determine the objective consensus. Based on information from multiple sources in decision tree format, treatment recommendations can be assessed for every parameter combination. An objective consensus can be determined by means of mode recommendations without compromise or confrontation among the parties. In the clinical example involving prostate cancer therapy, three parameters were used with two cut-off values each (Gleason score, PSA, T-stage) resulting in a total of 27 possible combinations per decision tree. Despite significant variations among the recommendations, a mode recommendation could be found for specific combinations of parameters. Recommendations represented as decision trees can serve as a basis for objective consensus among multiple parties.

HANFORD DST THERMAL & SEISMIC PROJECT ANSYS BENCHMARK ANALYSIS OF SEISMIC INDUCED FLUID STRUCTURE INTERACTION IN A HANFORD DOUBLE SHELL PRIMARY TANK

DOE Office of Scientific and Technical Information (OSTI.GOV)

MACKEY, T.C.

M&D Professional Services, Inc. (M&D) is under subcontract to Pacific Northwest National Laboratories (PNNL) to perform seismic analysis of the Hanford Site Double-Shell Tanks (DSTs) in support of a project entitled ''Double-Shell Tank (DSV Integrity Project-DST Thermal and Seismic Analyses)''. The overall scope of the project is to complete an up-to-date comprehensive analysis of record of the DST System at Hanford in support of Tri-Party Agreement Milestone M-48-14. The work described herein was performed in support of the seismic analysis of the DSTs. The thermal and operating loads analysis of the DSTs is documented in Rinker et al. (2004). Themore » overall seismic analysis of the DSTs is being performed with the general-purpose finite element code ANSYS. The overall model used for the seismic analysis of the DSTs includes the DST structure, the contained waste, and the surrounding soil. The seismic analysis of the DSTs must address the fluid-structure interaction behavior and sloshing response of the primary tank and contained liquid. ANSYS has demonstrated capabilities for structural analysis, but the capabilities and limitations of ANSYS to perform fluid-structure interaction are less well understood. The purpose of this study is to demonstrate the capabilities and investigate the limitations of ANSYS for performing a fluid-structure interaction analysis of the primary tank and contained waste. To this end, the ANSYS solutions are benchmarked against theoretical solutions appearing in BNL 1995, when such theoretical solutions exist. When theoretical solutions were not available, comparisons were made to theoretical solutions of similar problems and to the results from Dytran simulations. The capabilities and limitations of the finite element code Dytran for performing a fluid-structure interaction analysis of the primary tank and contained waste were explored in a parallel investigation (Abatt 2006). In conjunction with the results of the global ANSYS analysis reported in Carpenter et al. (2006), the results of the two investigations will be compared to help determine if a more refined sub-model of the primary tank is necessary to capture the important fluid-structure interaction effects in the tank and if so, how to best utilize a refined sub-model of the primary tank. Both rigid tank and flexible tank configurations were analyzed with ANSYS. The response parameters of interest are total hydrodynamic reaction forces, impulsive and convective mode frequencies, waste pressures, and slosh heights. To a limited extent: tank stresses are also reported. The results of this study demonstrate that the ANSYS model has the capability to adequately predict global responses such as frequencies and overall reaction forces. Thus, the model is suitable for predicting the global response of the tank and contained waste. On the other hand, while the ANSYS model is capable of adequately predicting waste pressures and primary tank stresses in a large portion of the waste tank, the model does not accurately capture the convective behavior of the waste near the free surface, nor did the model give accurate predictions of slosh heights. Based on the ability of the ANSYS benchmark model to accurately predict frequencies and global reaction forces and on the results presented in Abatt, et al. (2006), the global ANSYS model described in Carpenter et al. (2006) is sufficient for the seismic evaluation of all tank components except for local areas of the primary tank. Due to the limitations of the ANSYS model in predicting the convective response of the waste, the evaluation of primary tank stresses near the waste free surface should be supplemented by results from an ANSYS sub-model of the primary tank that incorporates pressures from theoretical solutions or from Dytran solutions. However, the primary tank is expected to have low demand to capacity ratios in the upper wall. Moreover, due to the less than desired mesh resolution in the primary tank knuckle of the global ANSYS model, the evaluation of the primary tank stresses in the lower knuckle should be supplemented by results from a more refined ANSYS sub-model of the primary tank that incorporates pressures from theoretical solutions or from Dytran solutions.« less

Characteristics of liver fibrosis with different etiologies using a fully quantitative fibrosis assessment tool.

PubMed

Wu, Q; Zhao, X; You, H

2017-05-18

This study aimed to test the diagnostic performance of a fully quantitative fibrosis assessment tool for liver fibrosis in patients with chronic hepatitis B (CHB), primary biliary cirrhosis (PBC) and non-alcoholic steatohepatitis (NASH). A total of 117 patients with liver fibrosis were included in this study, including 50 patients with CHB, 49 patients with PBC and 18 patients with NASH. All patients underwent liver biopsy (LB). Fibrosis stages were assessed by two experienced pathologists. Histopathological images of LB slices were processed by second harmonic generation (SHG)/two-photon excited fluorescence (TPEF) microscopy without staining, a system called qFibrosis (quantitative fibrosis) system. Altogether 101 quantitative features of the SHG/TPEF images were acquired. The parameters of aggregated collagen in portal, septal and fibrillar areas increased significantly with stages of liver fibrosis in PBC and CHB (P<0.05), but the same was not found for parameters of distributed collagen (P>0.05). There was a significant correlation between parameters of aggregated collagen in portal, septal and fibrillar areas and stages of liver fibrosis from CHB and PBC (P<0.05), but no correlation was found between the distributed collagen parameters and the stages of liver fibrosis from those patients (P>0.05). There was no significant correlation between NASH parameters and stages of fibrosis (P>0.05). For CHB and PBC patients, the highest correlation was between septal parameters and fibrosis stages, the second highest was between portal parameters and fibrosis stages and the lowest correlation was between fibrillar parameters and fibrosis stages. The correlation between the septal parameters of the PBC and stages is significantly higher than the parameters of the other two areas (P<0.05). The qFibrosis candidate parameters based on CHB were also applicable for quantitative analysis of liver fibrosis in PBC patients. Different parameters should be selected for liver fibrosis assessment in different stages of PBC compared with CHB.

Characteristics of liver fibrosis with different etiologies using a fully quantitative fibrosis assessment tool

PubMed Central

Wu, Q.; Zhao, X.; You, H.

2017-01-01

This study aimed to test the diagnostic performance of a fully quantitative fibrosis assessment tool for liver fibrosis in patients with chronic hepatitis B (CHB), primary biliary cirrhosis (PBC) and non-alcoholic steatohepatitis (NASH). A total of 117 patients with liver fibrosis were included in this study, including 50 patients with CHB, 49 patients with PBC and 18 patients with NASH. All patients underwent liver biopsy (LB). Fibrosis stages were assessed by two experienced pathologists. Histopathological images of LB slices were processed by second harmonic generation (SHG)/two-photon excited fluorescence (TPEF) microscopy without staining, a system called qFibrosis (quantitative fibrosis) system. Altogether 101 quantitative features of the SHG/TPEF images were acquired. The parameters of aggregated collagen in portal, septal and fibrillar areas increased significantly with stages of liver fibrosis in PBC and CHB (P<0.05), but the same was not found for parameters of distributed collagen (P>0.05). There was a significant correlation between parameters of aggregated collagen in portal, septal and fibrillar areas and stages of liver fibrosis from CHB and PBC (P<0.05), but no correlation was found between the distributed collagen parameters and the stages of liver fibrosis from those patients (P>0.05). There was no significant correlation between NASH parameters and stages of fibrosis (P>0.05). For CHB and PBC patients, the highest correlation was between septal parameters and fibrosis stages, the second highest was between portal parameters and fibrosis stages and the lowest correlation was between fibrillar parameters and fibrosis stages. The correlation between the septal parameters of the PBC and stages is significantly higher than the parameters of the other two areas (P<0.05). The qFibrosis candidate parameters based on CHB were also applicable for quantitative analysis of liver fibrosis in PBC patients. Different parameters should be selected for liver fibrosis assessment in different stages of PBC compared with CHB. PMID:28538834

Photosynthetic parameters in the Beaufort Sea in relation to the phytoplankton community structure

NASA Astrophysics Data System (ADS)

Huot, Y.; Babin, M.; Bruyant, F.

2013-05-01

To model phytoplankton primary production from remotely sensed data, a method to estimate photosynthetic parameters describing the photosynthetic rates per unit biomass is required. Variability in these parameters must be related to environmental variables that are measurable remotely. In the Arctic, a limited number of measurements of photosynthetic parameters have been carried out with the concurrent environmental variables needed. Such measurements and their relationship to environmental variables will be required to improve the accuracy of remotely sensed estimates of phytoplankton primary production and our ability to predict future changes. During the MALINA cruise, a large dataset of these parameters was obtained. Together with previously published datasets, we use environmental and trophic variables to provide functional relationships for these parameters. In particular, we describe several specific aspects: the maximum rate of photosynthesis (Pmaxchl) normalized to chlorophyll decreases with depth and is higher for communities composed of large cells; the saturation parameter (Ek) decreases with depth but is independent of the community structure; and the initial slope of the photosynthesis versus irradiance curve (αchl) normalized to chlorophyll is independent of depth but is higher for communities composed of larger cells. The photosynthetic parameters were not influenced by temperature over the range encountered during the cruise (-2 to 8 °C).

Photosynthetic parameters in the Beaufort Sea in relation to the phytoplankton community structure

NASA Astrophysics Data System (ADS)

Huot, Y.; Babin, M.; Bruyant, F.

2013-01-01

To model phytoplankton primary production from remotely sensed data a method to estimate photosynthetic parameters describing the photosynthetic rates per unit biomass is required. Variability in these parameters must be related to environmental variables that are measurable remotely. In the Arctic, a limited number of measurements of photosynthetic parameter have been carried out with the concurrent environmental variables needed. Therefore, to improve the accuracy of remote estimates of phytoplankton primary production as well as our ability to predict changes in the future such measurements and relationship to environmental variables are required. During the MALINA cruise, a large dataset of these parameters were obtained. Together with previously published datasets, we use environmental and trophic variables to provide functional relationships for these parameters. In particular, we describe several specific aspects: the maximum rate of photosynthesis (Pmaxchl) normalized to chlorophyll decreases with depth and is higher for communities composed of large cells; the saturation parameter (Ek) decreases with depth but is independent of the community structure; and the initial slope of the photosynthesis versus irradiance curve (αchl) normalized to chlorophyll is independent of depth but is higher for communities composed of larger cells. The photosynthetic parameters were not influenced by temperature over the range encountered during the cruise (-2 to 8 °C).

Fitness levels of Greek primary schoolchildren in relationship to overweight and obesity.

PubMed

Tokmakidis, Savvas P; Kasambalis, Athanasios; Christodoulos, Antonios D

2006-12-01

The aim of the present cross-sectional study was to provide estimates for overweight and obesity in a sample of Greek schoolchildren and to determine their possible relation with selected motor and health-related fitness parameters. The study sample consisted of 709 healthy children (328 girls, 381 boys, mean age = 8.9+/-1.6 years), living in the towns of Agios Stefanos (approximately 12,000 citizens) and Alexandroupolis (approximately 60,000 citizens), Greece. All pupils underwent anthropometric, motor and cardiovascular fitness assessments (Eurofit test battery). The body mass index (BMI) cut-off points adopted by the International Obesity Task Force were utilized for the assessment of overweight and obesity. 59.4% of the participants had a normal BMI, 25.8% were overweight and 14.8% were obese, without significant differences between genders. In general, the higher BMI categories were strongly associated with inferior performances in all fitness tests, except flexibility. This graded relationship was consistent for both boys and girls, although the statistical relationship between BMI categories and fitness performance varied by gender. In conclusion, the findings of the current study offer some support to the reported high prevalence of childhood obesity in Greece and suggest that overweight and obesity are limiting factors for fitness performance in primary schoolchildren. The present data suggest that interventions promoting children's health should, ideally, begin early in life and involve measures that simultaneously improve fitness and lower fatness.

Utility of Endoanal Ultrasonography in Assessment of Primary and Recurrent Anal Fistulas and for Detection of Associated Anal Sphincter Defects.

PubMed

Emile, Sameh Hany; Magdy, Alaa; Youssef, Mohamed; Thabet, Waleed; Abdelnaby, Mahmoud; Omar, Waleed; Khafagy, Wael

2017-11-01

Tridimensional endoanal ultrasonography (3D-EAUS) has been used for the assessment of various anorectal lesions. Previous studies have reported good accuracy of 3D-EAUS in preoperative assessment of fistula-in-ano (FIA). This study aimed to assess the diagnostic utility of 3D-EAUS in preoperative evaluation of primary and recurrent FIA and its role in detection of associated anal sphincter (AS) defects. Prospectively collected data of patients with FIA who were investigated with 3D-EAUS were reviewed. The findings of EAUS were compared with the intraoperative findings, the reference standard, to find the degree of agreement regarding the position of the internal opening (IO) and primary tract (PT), and presence of secondary tracts using kappa (k) coefficient test. A subgroup analysis was performed to compare the accuracy and sensitivity of EAUS for primary and recurrent FIA. Of the patients, 131 were included to the study. EAUS had an overall accuracy of 87, 88.5, and 89.5% in detection of IO, PT, and AS defects, respectively. There was very good concordance between the findings of EAUS and intraoperative findings for the investigated parameters (kappa = 0.748, 0.83, 0.935), respectively. Accuracy and sensitivity of EAUS in recurrent FIA were insignificantly lower than primary cases. EAUS detected occult AS defects in 5.3% of the patients studied. The diagnostic utility of 3D-EAUS was comparable in primary and recurrent FIA. 3D-EAUS was able to detect symptomatic and occult AS defects with higher accuracy than clinical examination.

Performance of a continuously rotating half-wave plate on the POLARBEAR telescope

DOE Office of Scientific and Technical Information (OSTI.GOV)

Takakura, Satoru; Aguilar, Mario; Akiba, Yoshiki

A continuously rotating half-wave plate (CRHWP) is a promising tool to improve the sensitivity to large angular scales in cosmic microwave background (CMB) polarization measurements. With a CRHWP, single detectors can measure three of the Stokes parameters, I, Q and U, thereby avoiding the set of systematic errors that can be introduced by mismatches in the properties of orthogonal detector pairs. We focus on the implementation of CRHWPs in large aperture telescopes (i.e. the primary mirror is larger than the current maximum half-wave plate diameter of ~0.5 m), where the CRHWP can be placed between the primary mirror and focalmore » plane. In this configuration, one needs to address the intensity to polarization (I→P) leakage of the optics, which becomes a source of 1/f noise and also causes differential gain systematics that arise from CMB temperature fluctuations. In this paper, we present the performance of a CRHWP installed in the {\\scshape Polarbear} experiment, which employs a Gregorian telescope with a 2.5 m primary illumination pattern. The CRHWP is placed near the prime focus between the primary and secondary mirrors. We find that the I→P leakage is larger than the expectation from the physical properties of our primary mirror, resulting in a 1/f knee of 100 mHz. The excess leakage could be due to imperfections in the detector system, i.e. detector non-linearity in the responsivity and time-constant. We demonstrate, however, that by subtracting the leakage correlated with the intensity signal, the 1/f noise knee frequency is reduced to 32 mHz (ℓ ~ 39 for our scan strategy), which is very promising to probe the primordial B-mode signal. We also discuss methods for further noise subtraction in future projects where the precise temperature control of instrumental components and the leakage reduction will play a key role.« less

Performance of a continuously rotating half-wave plate on the POLARBEAR telescope

DOE PAGES

Takakura, Satoru; Aguilar, Mario; Akiba, Yoshiki; ...

2017-05-03

A continuously rotating half-wave plate (CRHWP) is a promising tool to improve the sensitivity to large angular scales in cosmic microwave background (CMB) polarization measurements. With a CRHWP, single detectors can measure three of the Stokes parameters, I, Q and U, thereby avoiding the set of systematic errors that can be introduced by mismatches in the properties of orthogonal detector pairs. We focus on the implementation of CRHWPs in large aperture telescopes (i.e. the primary mirror is larger than the current maximum half-wave plate diameter of ~0.5 m), where the CRHWP can be placed between the primary mirror and focalmore » plane. In this configuration, one needs to address the intensity to polarization (I→P) leakage of the optics, which becomes a source of 1/f noise and also causes differential gain systematics that arise from CMB temperature fluctuations. In this paper, we present the performance of a CRHWP installed in the {\\scshape Polarbear} experiment, which employs a Gregorian telescope with a 2.5 m primary illumination pattern. The CRHWP is placed near the prime focus between the primary and secondary mirrors. We find that the I→P leakage is larger than the expectation from the physical properties of our primary mirror, resulting in a 1/f knee of 100 mHz. The excess leakage could be due to imperfections in the detector system, i.e. detector non-linearity in the responsivity and time-constant. We demonstrate, however, that by subtracting the leakage correlated with the intensity signal, the 1/f noise knee frequency is reduced to 32 mHz (ℓ ~ 39 for our scan strategy), which is very promising to probe the primordial B-mode signal. We also discuss methods for further noise subtraction in future projects where the precise temperature control of instrumental components and the leakage reduction will play a key role.« less

Performance of a continuously rotating half-wave plate on the POLARBEAR telescope

DOE Office of Scientific and Technical Information (OSTI.GOV)

Takakura, Satoru; Aguilar, Mario; Akiba, Yoshiki

A continuously rotating half-wave plate (CRHWP) is a promising tool to improve the sensitivity to large angular scales in cosmic microwave background (CMB) polarization measurements. With a CRHWP, single detectors can measure three of the Stokes parameters, I , Q and U , thereby avoiding the set of systematic errors that can be introduced by mismatches in the properties of orthogonal detector pairs. We focus on the implementation of CRHWPs in large aperture telescopes (i.e. the primary mirror is larger than the current maximum half-wave plate diameter of ∼0.5 m), where the CRHWP can be placed between the primary mirrormore » and focal plane. In this configuration, one needs to address the intensity to polarization ( I → P ) leakage of the optics, which becomes a source of 1/f noise and also causes differential gain systematics that arise from CMB temperature fluctuations. In this paper, we present the performance of a CRHWP installed in the (\\scshape Polarbear) experiment, which employs a Gregorian telescope with a 2.5 m primary illumination pattern. The CRHWP is placed near the prime focus between the primary and secondary mirrors. We find that the I → P leakage is larger than the expectation from the physical properties of our primary mirror, resulting in a 1/f knee of 100 mHz. The excess leakage could be due to imperfections in the detector system, i.e. detector non-linearity in the responsivity and time-constant. We demonstrate, however, that by subtracting the leakage correlated with the intensity signal, the 1/f noise knee frequency is reduced to 32 mHz (ℓ ∼ 39 for our scan strategy), which is very promising to probe the primordial B-mode signal. We also discuss methods for further noise subtraction in future projects where the precise temperature control of instrumental components and the leakage reduction will play a key role.« less

Ion beam sputtering of Ag - Angular and energetic distributions of sputtered and scattered particles

NASA Astrophysics Data System (ADS)

Feder, René; Bundesmann, Carsten; Neumann, Horst; Rauschenbach, Bernd

2013-12-01

Ion beam sputter deposition (IBD) provides intrinsic features which influence the properties of the growing film, because ion properties and geometrical process conditions generate different energy and spatial distribution of the sputtered and scattered particles. A vacuum deposition chamber is set up to measure the energy and spatial distribution of secondary particles produced by ion beam sputtering of different target materials under variation of geometrical parameters (incidence angle of primary ions and emission angle of secondary particles) and of primary ion beam parameters (ion species and energies).

A novel compact model for on-chip stacked transformers in RF-CMOS technology

NASA Astrophysics Data System (ADS)

Jun, Liu; Jincai, Wen; Qian, Zhao; Lingling, Sun

2013-08-01

A novel compact model for on-chip stacked transformers is presented. The proposed model topology gives a clear distinction to the eddy current, resistive and capacitive losses of the primary and secondary coils in the substrate. A method to analytically determine the non-ideal parasitics between the primary coil and substrate is provided. The model is further verified by the excellent match between the measured and simulated S -parameters on the extracted parameters for a 1 : 1 stacked transformer manufactured in a commercial RF-CMOS technology.

The prediction of progression-free and overall survival in women with an advanced stage of epithelial ovarian carcinoma.

PubMed

Gerestein, C G; Eijkemans, M J C; de Jong, D; van der Burg, M E L; Dykgraaf, R H M; Kooi, G S; Baalbergen, A; Burger, C W; Ansink, A C

2009-02-01

Prognosis in women with ovarian cancer mainly depends on International Federation of Gynecology and Obstetrics stage and the ability to perform optimal cytoreductive surgery. Since ovarian cancer has a heterogeneous presentation and clinical course, predicting progression-free survival (PFS) and overall survival (OS) in the individual patient is difficult. The objective of this study was to determine predictors of PFS and OS in women with advanced stage epithelial ovarian cancer (EOC) after primary cytoreductive surgery and first-line platinum-based chemotherapy. Retrospective observational study. Two teaching hospitals and one university hospital in the south-western part of the Netherlands. Women with advanced stage EOC. All women who underwent primary cytoreductive surgery for advanced stage EOC followed by first-line platinum-based chemotherapy between January 1998 and October 2004 were identified. To investigate independent predictors of PFS and OS, a Cox' proportional hazard model was used. Nomograms were generated with the identified predictive parameters. The primary outcome measure was OS and the secondary outcome measures were response and PFS. A total of 118 women entered the study protocol. Median PFS and OS were 15 and 44 months, respectively. Preoperative platelet count (P = 0.007), and residual disease <1 cm (P = 0.004) predicted PFS with a optimism corrected c-statistic of 0.63. Predictive parameters for OS were preoperative haemoglobin serum concentration (P = 0.012), preoperative platelet counts (P = 0.031) and residual disease <1 cm (P = 0.028) with a optimism corrected c-statistic of 0.67. PFS could be predicted by postoperative residual disease and preoperative platelet counts, whereas residual disease, preoperative platelet counts and preoperative haemoglobin serum concentration were predictive for OS. The proposed nomograms need to be externally validated.

Nonpharmacologic treatment of chronic insomnia. An American Academy of Sleep Medicine review.

PubMed

Morin, C M; Hauri, P J; Espie, C A; Spielman, A J; Buysse, D J; Bootzin, R R

1999-12-15

This paper reviews the evidence regarding the efficacy of nonpharmacological treatments for primary chronic insomnia. It is based on a review of 48 clinical trials and two meta-analyses conducted by a task force appointed by the American Academy of Sleep Medicine to develop practice parameters on non-drug therapies for the clinical management of insomnia. The findings indicate that nonpharmacological therapies produce reliable and durable changes in several sleep parameters of chronic insomnia sufferers. The data indicate that between 70% and 80% of patients treated with nonpharmacological interventions benefit from treatment. For the typical patient with persistent primary insomnia, treatment is likely to reduce the main target symptoms of sleep onset latency and/or wake time after sleep onset below or near the 30-min criterion initially used to define insomnia severity. Sleep duration is also increased by a modest 30 minutes and sleep quality and patient's satisfaction with sleep patterns are significantly enhanced. Sleep improvements achieved with these behavioral interventions are sustained for at least 6 months after treatment completion. However, there is no clear evidence that improved sleep leads to meaningful changes in daytime well-being or performance. Three treatments meet the American Psychological Association (APA) criteria for empirically-supported psychological treatments for insomnia: Stimulus control, progressive muscle relaxation, and paradoxical intention; and three additional treatments meet APA criteria for probably efficacious treatments: Sleep restriction, biofeedback, and multifaceted cognitive-behavior therapy. Additional outcome research is needed to examine the effectiveness of treatment when it is implemented in clinical settings (primary care, family practice), by non-sleep specialists, and with insomnia patients presenting medical or psychiatric comorbidity.

Reducing the uncertainty of parameters controlling seasonal carbon and water fluxes in Chinese forests and its implication for simulated climate sensitivities

NASA Astrophysics Data System (ADS)

Li, Yue; Yang, Hui; Wang, Tao; MacBean, Natasha; Bacour, Cédric; Ciais, Philippe; Zhang, Yiping; Zhou, Guangsheng; Piao, Shilong

2017-08-01

Reducing parameter uncertainty of process-based terrestrial ecosystem models (TEMs) is one of the primary targets for accurately estimating carbon budgets and predicting ecosystem responses to climate change. However, parameters in TEMs are rarely constrained by observations from Chinese forest ecosystems, which are important carbon sink over the northern hemispheric land. In this study, eddy covariance data from six forest sites in China are used to optimize parameters of the ORganizing Carbon and Hydrology In Dynamics EcosystEms TEM. The model-data assimilation through parameter optimization largely reduces the prior model errors and improves the simulated seasonal cycle and summer diurnal cycle of net ecosystem exchange, latent heat fluxes, and gross primary production and ecosystem respiration. Climate change experiments based on the optimized model are deployed to indicate that forest net primary production (NPP) is suppressed in response to warming in the southern China but stimulated in the northeastern China. Altered precipitation has an asymmetric impact on forest NPP at sites in water-limited regions, with the optimization-induced reduction in response of NPP to precipitation decline being as large as 61% at a deciduous broadleaf forest site. We find that seasonal optimization alters forest carbon cycle responses to environmental change, with the parameter optimization consistently reducing the simulated positive response of heterotrophic respiration to warming. Evaluations from independent observations suggest that improving model structure still matters most for long-term carbon stock and its changes, in particular, nutrient- and age-related changes of photosynthetic rates, carbon allocation, and tree mortality.

Correlation between thermal parameters, structures, dendritic spacing and corrosion behavior of Zn Al alloys with columnar to equiaxed transition

NASA Astrophysics Data System (ADS)

Ares, A. E.; Gassa, L. M.; Gueijman, S. F.; Schvezov, C. E.

2008-04-01

The columnar to equiaxed transition (CET) has been examined for many years and the significance of CET has been treated in several articles. Experimental observations in different alloy systems have shown that the position of the transition is dependent on parameters like cooling rate, velocity of the liquidus and solidus fronts, local solidification time, temperature gradients and recalescence. The dendritic structure in alloys results in microsegregation of solute species which affects significantly the mechanical properties of the material. The main parameters characterizing the microstructure and the length range of microsegregation is the spacing which is classified as primary, secondary and tertiary. Properties like mechanical resistance and ductility are influenced by the dimensions and continuity of the primary branches, while the secondary and tertiary branches permit the isolation of interdendritic phases which can deteriorate the mechanical behavior of the material. Since the morphology and dimensions of the dendritic structure is related to the solidification parameters mentioned above, for each type of alloy it is essential to correlate dimensions and solidification conditions in order to control the structure. The objective of the present research consists on studying the influence of solidification thermal parameters with the type of structure (columnar, equiaxial or with the CET); and with grain size and dendritic spacing (primary and secondary) in Zn-Al (ZA) alloys (Zn—4 wt%Al, Zn—16 wt%Al and Zn—27 wt%Al, weight percent). Also, correlate the thermal parameters, type of structure, grain size and dendritic spacing with the corrosion resistance of these alloys.

Computational modeling of colorimetric primary transducer for metrological assurance in additive manufacturing

NASA Astrophysics Data System (ADS)

Skliarov, Volodymyr

2018-03-01

Many additive manufacturing (AM) systems are based on laser technology. The advantage of laser technology is that it provides a high-intensity and high-collimation energy beam that can be controlled. Since AM requires that the material on each layer has to be solid or connected to the previous one, the energy of laser radiation is exactly the needed technical tool for the processing of the material. AM uses two types of laser processing: cutting and heating. One of the most popular (common) types of measurements in the field of laser metrology is the control of the energy parameters of the sources of laser radiation. At present, calorimeters provide the highest accuracy of absolute measurements of laser radiation in the power range from several watts to tens of kilowatts. The main elements that determine the accuracy of reproduction, maintenance and transfer of the unit of laser power are the primary measuring converters (PMCs), which are the part of the equipment of the national primary measurement standards of Ukraine. A significant contribution to the uncertainty budget of the primary measuring calorimetric converter is the unbalanced replacement of laser radiation by the heat flux that calibrates this converter. The heterogeneous internal structure of the calorimetric primary converter, the nonlinearity of processes occurring in it, and the multifactorial process of its calibration substantially complicate the development of primary measuring converters. The purpose of this paper is to simulate the thermal field of the primary converter for maximum reduction of the uncertainty of calibration. The presented research is a part of the scientific work that NSC "Institute of Metrology" carries out under COOMET and EMPIRE projects. The modeling was performed in the academic version of ANSYS.

How reproducible is cutaneous electrogastrography? An in-depth evidence-based study.

PubMed

Jonderko, K; Kasicka-Jonderko, A; Krusiec-Swidergoł, B; Dzielicki, M; Strój, L; Doliński, M; Doliński, K; Błońska-Fajfrowska, B

2005-12-01

To check on reproducibility of parameters of the cutaneous electrogastrogram registered at a close or a distant time span. Twenty-two volunteers recruited by an advertisement (11 females and 11 males, median age 25 years, range: 18-35) underwent three surface electrogastrography examinations of which two were taken on consecutive days and the third one was accomplished at least 2 weeks before or after the two other sessions. The examination involved a 30-min fasted recording, followed by a 90-min postprandial registration after intake of a 394-kcal mixed solid-liquid test meal. Parameters of the electrogastrogram pertaining to the frequency of the gastric slow waves exhibited good to moderate reproducibility, whereas fair reproducibility characterized parameters expected to describe the power of gastric slow waves. With the exception of the difference fed minus fasted power (DeltaDP), in no instance was the medium term reproducibility any worse than the short term one. Categorical data analysis revealed that the relative time share of normogastria postprandially exhibited a better reproducibility than in the fasted period. The Cohen's kappa-value of 0.459 for the DeltaDP for the medium term reproducibility placed this parameter within the range of moderate agreement between repeat examinations. Of the two two-parameter combinations considered, the alliance of the fasted and fed normogastria performed worse than any of those parameters considered alone, whereas a combination of the DeltaDP with the fed-state normogastria revealed a kappa-value amounting to 0.510 for the medium term reproducibility. The feasibility of some electrogastrographic parameters to convey clinically useful information may be hampered by their fair reproducibility. Recoding of parameters of the cutaneous electrogastrogram from primary continuous to secondary categorical may help achieve a better agreement between repeat examinations.

Rec.2100 color gamut revelation using spectrally ultranarrow emitters

NASA Astrophysics Data System (ADS)

Genc, Sinan; Uguz, Mustafa; Yilmaz, Osman; Mutlugun, Evren

2017-11-01

We theoretically simulate the performance of ultranarrow emitters for the first time to achieve record high coverage for the International Telecommunication Union Radiocommunication Sector BT.2100 (Rec.2100) and National Television System Committee (NTSC) color gamut. Our results, employing more than 130-m parameter sets, include the investigation into peak emission wavelength and full width at half maximum (FWHM) values for three primaries that show ultranarrow emitters, i.e., nanoplatelets are potentially promising materials to fully cover the Rec.2100 color gamut. Using ultranarrow emitters having FWHM as low as 6 nm can provide the ability to attain 99.7% coverage area of the Rec.2100 color gamut as well as increasing the NTSC triangle to 133.7% with full coverage. The parameter set that provides possibility to fully reach Rec.2100 also has been shown to match with D65 white light by making use of the correct combination of those three primaries. Furthermore, we investigate the effect of the fourth color component on the CIE 1931 color space without sacrificing the achieved coverage percentages. The investigation into the fourth color component, cyan, is shown for the first time to enhance the Rec.2100 gamut area to 127.7% with 99.9% coverage. The fourth color component also provides an NTSC coverage ratio of 171.5%. The investigation into the potential of emitters with ultranarrow emission bandwidth holds great promise for future display applications.

On the Role of Imitation on Adolescence Methamphetamine Abuse Dynamics.

PubMed

Mushanyu, J; Nyabadza, F; Muchatibaya, G; Stewart, A G R

2017-03-01

Adolescence methamphetamine use is an issue of considerable concern due to its correlation with later delinquency, divorce, unemployment and health problems. Understanding how adolescents initiate methamphetamine abuse is important in developing effective prevention programs. We formulate a mathematical model for the spread of methamphetamine abuse using nonlinear ordinary differential equations. It is assumed that susceptibles are recruited into methamphetamine use through imitation. An epidemic threshold value, [Formula: see text], termed the abuse reproduction number, is proposed and defined herein in the drug-using context. The model is shown to exhibit the phenomenon of backward bifurcation. This means that methamphetamine problems may persist in the population even if [Formula: see text] is less than one. Sensitivity analysis of [Formula: see text] was performed to determine the relative importance of different parameters in methamphetamine abuse initiation. The model is then fitted to data on methamphetamine users less than 20 years old reporting methamphetamine as their primary substance of abuse in the treatment centres of Cape Town and parameter values that give the best fit are chosen. Results show that the proportion of methamphetamine users less than 20 years old reporting methamphetamine as their primary substance of abuse will continue to decrease in Cape Town of South Africa. The results suggest that intervention programs targeted at reducing adolescence methamphetamine abuse, are positively impacting methamphetamine abuse.

Effectiveness of a School-Based Physical Activity Intervention on Cognitive Performance in Danish Adolescents: LCoMotion—Learning, Cognition and Motion – A Cluster Randomized Controlled Trial

PubMed Central

Domazet, Sidsel Louise; Froberg, Karsten; Hillman, Charles H.; Andersen, Lars Bo; Bugge, Anna

2016-01-01

Background Physical activity is associated not only with health-related parameters, but also with cognitive and academic performance. However, no large scale school-based physical activity interventions have investigated effects on cognitive performance in adolescents. The aim of this study was to describe the effectiveness of a school-based physical activity intervention in enhancing cognitive performance in 12–14 years old adolescents. Methods A 20 week cluster randomized controlled trial was conducted including seven intervention and seven control schools. A total of 632 students (mean (SD) age: 12.9 (0.6) years) completed the trial with baseline and follow-up data on primary or secondary outcomes (74% of randomized subjects). The intervention targeted physical activity during academic subjects, recess, school transportation and leisure-time. Cognitive performance was assessed using an executive functions test of inhibition (flanker task) with the primary outcomes being accuracy and reaction time on congruent and incongruent trials. Secondary outcomes included mathematics performance, physical activity levels, body-mass index, waist-circumference and cardiorespiratory fitness. Results No significant difference in change, comparing the intervention group to the control group, was observed on the primary outcomes (p’s>0.05) or mathematics skills (p>0.05). An intervention effect was found for cardiorespiratory fitness in girls (21 meters (95% CI: 4.4–38.6) and body-mass index in boys (-0.22 kg/m2 (95% CI: -0.39–0.05). Contrary to our predictions, a significantly larger change in interference control for reaction time was found in favor of the control group (5.0 milliseconds (95% CI: 0–9). Baseline to mid-intervention changes in physical activity levels did not differ significantly between groups (all p’s>0.05). Conclusions No evidence was found for effectiveness of a 20-week multi-faceted school-based physical activity intervention for enhancing executive functioning or mathematics skills compared to a control group, but low implementation fidelity precludes interpretation of the causal relationship. Trial Registration www.ClinicalTrials.gov NCT02012881 PMID:27341346

Effectiveness of a School-Based Physical Activity Intervention on Cognitive Performance in Danish Adolescents: LCoMotion-Learning, Cognition and Motion - A Cluster Randomized Controlled Trial.

PubMed

Tarp, Jakob; Domazet, Sidsel Louise; Froberg, Karsten; Hillman, Charles H; Andersen, Lars Bo; Bugge, Anna

2016-01-01

Physical activity is associated not only with health-related parameters, but also with cognitive and academic performance. However, no large scale school-based physical activity interventions have investigated effects on cognitive performance in adolescents. The aim of this study was to describe the effectiveness of a school-based physical activity intervention in enhancing cognitive performance in 12-14 years old adolescents. A 20 week cluster randomized controlled trial was conducted including seven intervention and seven control schools. A total of 632 students (mean (SD) age: 12.9 (0.6) years) completed the trial with baseline and follow-up data on primary or secondary outcomes (74% of randomized subjects). The intervention targeted physical activity during academic subjects, recess, school transportation and leisure-time. Cognitive performance was assessed using an executive functions test of inhibition (flanker task) with the primary outcomes being accuracy and reaction time on congruent and incongruent trials. Secondary outcomes included mathematics performance, physical activity levels, body-mass index, waist-circumference and cardiorespiratory fitness. No significant difference in change, comparing the intervention group to the control group, was observed on the primary outcomes (p's>0.05) or mathematics skills (p>0.05). An intervention effect was found for cardiorespiratory fitness in girls (21 meters (95% CI: 4.4-38.6) and body-mass index in boys (-0.22 kg/m2 (95% CI: -0.39-0.05). Contrary to our predictions, a significantly larger change in interference control for reaction time was found in favor of the control group (5.0 milliseconds (95% CI: 0-9). Baseline to mid-intervention changes in physical activity levels did not differ significantly between groups (all p's>0.05). No evidence was found for effectiveness of a 20-week multi-faceted school-based physical activity intervention for enhancing executive functioning or mathematics skills compared to a control group, but low implementation fidelity precludes interpretation of the causal relationship. www.ClinicalTrials.gov NCT02012881.

[Parameter sensitivity of simulating net primary productivity of Larix olgensis forest based on BIOME-BGC model].

PubMed

He, Li-hong; Wang, Hai-yan; Lei, Xiang-dong

2016-02-01

Model based on vegetation ecophysiological process contains many parameters, and reasonable parameter values will greatly improve simulation ability. Sensitivity analysis, as an important method to screen out the sensitive parameters, can comprehensively analyze how model parameters affect the simulation results. In this paper, we conducted parameter sensitivity analysis of BIOME-BGC model with a case study of simulating net primary productivity (NPP) of Larix olgensis forest in Wangqing, Jilin Province. First, with the contrastive analysis between field measurement data and the simulation results, we tested the BIOME-BGC model' s capability of simulating the NPP of L. olgensis forest. Then, Morris and EFAST sensitivity methods were used to screen the sensitive parameters that had strong influence on NPP. On this basis, we also quantitatively estimated the sensitivity of the screened parameters, and calculated the global, the first-order and the second-order sensitivity indices. The results showed that the BIOME-BGC model could well simulate the NPP of L. olgensis forest in the sample plot. The Morris sensitivity method provided a reliable parameter sensitivity analysis result under the condition of a relatively small sample size. The EFAST sensitivity method could quantitatively measure the impact of simulation result of a single parameter as well as the interaction between the parameters in BIOME-BGC model. The influential sensitive parameters for L. olgensis forest NPP were new stem carbon to new leaf carbon allocation and leaf carbon to nitrogen ratio, the effect of their interaction was significantly greater than the other parameter' teraction effect.

Monitoring the metering performance of an electronic voltage transformer on-line based on cyber-physics correlation analysis

NASA Astrophysics Data System (ADS)

Zhang, Zhu; Li, Hongbin; Tang, Dengping; Hu, Chen; Jiao, Yang

2017-10-01

Metering performance is the key parameter of an electronic voltage transformer (EVT), and it requires high accuracy. The conventional off-line calibration method using a standard voltage transformer is not suitable for the key equipment in a smart substation, which needs on-line monitoring. In this article, we propose a method for monitoring the metering performance of an EVT on-line based on cyber-physics correlation analysis. By the electrical and physical properties of a substation running in three-phase symmetry, the principal component analysis method is used to separate the metering deviation caused by the primary fluctuation and the EVT anomaly. The characteristic statistics of the measured data during operation are extracted, and the metering performance of the EVT is evaluated by analyzing the change in statistics. The experimental results show that the method successfully monitors the metering deviation of a Class 0.2 EVT accurately. The method demonstrates the accurate evaluation of on-line monitoring of the metering performance on an EVT without a standard voltage transformer.

Recent studies of float and stall curves in controlled-clearance deadweight testers with a simple piston.

PubMed

Newhall, D H; Ogawa, I; Zilberstein, V

1979-08-01

The effect of piston rotation speed and fluid viscosity on the performance of free-piston gauges with a controlled clearance was studied as part of an experimental program aiming at the better evaluation of pressure by these primary pressure standards. Calculated effective area is shown to be greatly influenced by both speed of rotation and choice of a fluid. An optimum rpm resulting in the smallest possible uncertainty in effective area should be determined experimentally for each fluid and pressure range involved. When all the pertinent parameters are properly selected an appreciable improvement in accuracy can be achieved.

Design data package and operating procedures for MSFC solar simulator test facility

NASA Technical Reports Server (NTRS)

1981-01-01

Design and operational data for the solar simulator test facility are reviewed. The primary goal of the facility is to evaluate the performance capacibility and worst case failure modes of collectors, which utilize either air or liquid transport media. The facility simulates environmental parameters such as solar radiation intensity, solar spectrum, collimation, uniformity, and solar attitude. The facility also simulates wind conditions of velocity and direction, solar system conditions imposed on the collector, collector fluid inlet temperature, and geometric factors of collector tilt and azimuth angles. Testing the simulator provides collector efficiency data, collector time constant, incident angle modifier data, and stagnation temperature values.

Primary prophylaxis for children with severe congenital factor VII deficiency - Clinical and laboratory assessment.

PubMed

Kuperman, A A; Barg, A A; Fruchtman, Y; Shaoul, E; Rosenberg, N; Kenet, G; Livnat, T

2017-09-01

Severe congenital factor VII (FVII) deficiency is a rare bleeding disorder. Prophylaxis with replacement therapy has been suggested to patients, yet the most beneficial dosing regimens and therapy intervals are still to be defined. Due to the lack of evidence-based data, we hereby present our experience with long-term administration and monitoring primary prophylaxis in children with severe FVII deficiency and an extremely high bleeding risk. Four children with familial FVII deficiency, treated by prophylactic recombinant activated factor VII (rFVIIa), 15-30μg/kg/dose, given 2-3 times weekly since infancy, are discussed. Clinical follow up and monitoring laboratory assays, including thrombin generation, measured at various time points after prophylactic rFVIIa administration are presented. Among our treated patients neither FVII activity nor thrombin generation parameters (both already declined 24h post rFVIIa administration) were able to predict the impact of prophylaxis, and could not be used as surrogate markers in order to assess the most beneficial treatment frequency. However, the long clinical follow-up and comprehensive laboratory assessment performed, have shown that early primary prophylaxis as administered in our cohort was safe and effective. Copyright © 2016 Elsevier Inc. All rights reserved.

Efficient hit-finding approaches for histone methyltransferases: the key parameters.

PubMed

Ahrens, Thomas; Bergner, Andreas; Sheppard, David; Hafenbradl, Doris

2012-01-01

For many novel epigenetics targets the chemical ligand space and structural information were limited until recently and are still largely unknown for some targets. Hit-finding campaigns are therefore dependent on large and chemically diverse libraries. In the specific case of the histone methyltransferase G9a, the authors have been able to apply an efficient process of intelligent selection of compounds for primary screening, rather than screening the full diverse deck of 900 000 compounds to identify hit compounds. A number of different virtual screening methods have been applied for the compound selection, and the results have been analyzed in the context of their individual success rates. For the primary screening of 2112 compounds, a FlashPlate assay format and full-length histone H3.1 substrate were employed. Validation of hit compounds was performed using the orthogonal fluorescence lifetime technology. Rated by purity and IC(50) value, 18 compounds (0.9% of compound screening deck) were finally considered validated primary G9a hits. The hit-finding approach has led to novel chemotypes being identified, which can facilitate hit-to-lead projects. This study demonstrates the power of virtual screening technologies for novel, therapeutically relevant epigenetics protein targets.

Comparison of Primary Models to Predict Microbial Growth by the Plate Count and Absorbance Methods.

PubMed

Pla, María-Leonor; Oltra, Sandra; Esteban, María-Dolores; Andreu, Santiago; Palop, Alfredo

2015-01-01

The selection of a primary model to describe microbial growth in predictive food microbiology often appears to be subjective. The objective of this research was to check the performance of different mathematical models in predicting growth parameters, both by absorbance and plate count methods. For this purpose, growth curves of three different microorganisms (Bacillus cereus, Listeria monocytogenes, and Escherichia coli) grown under the same conditions, but with different initial concentrations each, were analysed. When measuring the microbial growth of each microorganism by optical density, almost all models provided quite high goodness of fit (r(2) > 0.93) for all growth curves. The growth rate remained approximately constant for all growth curves of each microorganism, when considering one growth model, but differences were found among models. Three-phase linear model provided the lowest variation for growth rate values for all three microorganisms. Baranyi model gave a variation marginally higher, despite a much better overall fitting. When measuring the microbial growth by plate count, similar results were obtained. These results provide insight into predictive microbiology and will help food microbiologists and researchers to choose the proper primary growth predictive model.

Beam halo collimation in heavy ion synchrotrons

NASA Astrophysics Data System (ADS)

Strašík, I.; Prokhorov, I.; Boine-Frankenheim, O.

2015-08-01

This paper presents a systematic study of the halo collimation of ion beams from proton up to uranium in synchrotrons. The projected Facility for Antiproton and Ion Research synchrotron SIS100 is used as a reference case. The concepts are separated into fully stripped (e.g., 238U92+ ) and partially stripped (e.g., 238U28+ ) ion collimation. An application of the two-stage betatron collimation system, well established for proton accelerators, is intended also for fully stripped ions. The two-stage system consists of a primary collimator (a scattering foil) and secondary collimators (bulky absorbers). Interaction of the particles with the primary collimator (scattering, momentum losses, and nuclear interactions) was simulated by using fluka. Particle-tracking simulations were performed by using mad-x. Finally, the dependence of the collimation efficiency on the primary ion species was determined. The influence of the collimation system adjustment, lattice imperfections, and beam parameters was estimated. The concept for the collimation of partially stripped ions employs a thin stripping foil in order to change their charge state. These ions are subsequently deflected towards a dump location using a beam optical element. The charge state distribution after the stripping foil was obtained from global. The ions were tracked by using mad-x.

Changes of gait pattern in children with Charcot-Marie-Tooth disease type 1A: a 18 months follow-up study

PubMed Central

2013-01-01

Background In a previous study we identified 3 different gait patterns in a group of children with CMT1A disease: Normal-like (NL), Foot-drop (FD), Foot-drop and Push-off Deficit (FD&POD). Goal of the present study was to perform a follow-up evaluation of the same group of patients to analyze possible changes of gait features in relation to disease progression or specific therapy. Methods Nineteen children with CMT1A were evaluated clinically (CMT-Examination Score and Overall Neuropathy Limitation Scale) and through gait analysis 18.2±1.5 months after a baseline evaluation. Meanwhile, 3 of them had foot surgery. Results Fifteen out of the 16 non-operated patients significantly changed at least one of the two parameters associated to primary signs (FD and/or POD). Eleven participants worsened at least one parameter and 9 improved one parameter. CMTES significantly worsened for the group of non-operated patients. However, there was no change in CMTES score in 4 patients and in ONLS score in 11. At subgroup level, participants originally belonging to NL group showed a trend towards a foot-drop deficit (−15%, ns); FD and FD&POD subgroups did not change their primary signs, although significant changes were identified individually. All 3 patients operated have improved push-off and proximal joint patterns during walking. Clinical scores did not change within any sub-group. Conclusions Subtle changes occurring in 1.5 year in gait features of CMT1A children can be instrumentally identified. Such changes show a large inter-subject variability, with some patients even improving their walking pattern. There is anecdotal evidence that foot surgery may improve the push-off phase of gait. PMID:23819439

Changes of gait pattern in children with Charcot-Marie-Tooth disease type 1A: a 18 months follow-up study.

PubMed

Ferrarin, Maurizio; Lencioni, Tiziana; Rabuffetti, Marco; Moroni, Isabella; Pagliano, Emanuela; Pareyson, Davide

2013-07-02

In a previous study we identified 3 different gait patterns in a group of children with CMT1A disease: Normal-like (NL), Foot-drop (FD), Foot-drop and Push-off Deficit (FD&POD). Goal of the present study was to perform a follow-up evaluation of the same group of patients to analyze possible changes of gait features in relation to disease progression or specific therapy. Nineteen children with CMT1A were evaluated clinically (CMT-Examination Score and Overall Neuropathy Limitation Scale) and through gait analysis 18.2±1.5 months after a baseline evaluation. Meanwhile, 3 of them had foot surgery. Fifteen out of the 16 non-operated patients significantly changed at least one of the two parameters associated to primary signs (FD and/or POD). Eleven participants worsened at least one parameter and 9 improved one parameter. CMTES significantly worsened for the group of non-operated patients. However, there was no change in CMTES score in 4 patients and in ONLS score in 11. At subgroup level, participants originally belonging to NL group showed a trend towards a foot-drop deficit (-15%, ns); FD and FD&POD subgroups did not change their primary signs, although significant changes were identified individually. All 3 patients operated have improved push-off and proximal joint patterns during walking. Clinical scores did not change within any sub-group. Subtle changes occurring in 1.5 year in gait features of CMT1A children can be instrumentally identified. Such changes show a large inter-subject variability, with some patients even improving their walking pattern. There is anecdotal evidence that foot surgery may improve the push-off phase of gait.

Displacement cascades and defect annealing in tungsten, Part III: The sensitivity of cascade annealing in tungsten to the values of kinetic parameters

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nandipati, Giridhar; Setyawan, Wahyu; Heinisch, Howard L.

2015-07-01

Object kinetic Monte Carlo (OKMC) simulations have been performed to investigate various aspects of cascade aging in bulk tungsten and to determine the sensitivity of the results to the kinetic parameters. The primary focus is on how the kinetic parameters affect the initial recombination of defects in the first few ns of a simulation. The simulations were carried out using the object kinetic Monte Carlo (OKMC) code KSOME (kinetic simulations of microstructure evolution), using a database of cascades obtained from results of molecular dynamics (MD) simulations at various primary knock-on atom (PKA) energies and directions at temperatures of 300, 1025more » and 2050 K. The OKMC model was parameterized using defect migration barriers and binding energies from ab initio calculations. Results indicate that, due to the disparate mobilities of SIA and vacancy clusters in tungsten, annealing is dominated by SIA migration even at temperatures as high as 2050 K. For 100 keV cascades initiated at 300 K recombination is dominated by annihilation of large defect clusters. But for all other PKA energies and temperatures most of the recombination is due to the migration and rotation of small SIA clusters, while all the large SIA clusters escape the cubic simulation cell. The inverse U-shape behavior exhibited by the annealing efficiency as a function of temperature curve, especially for cascades of large PKA energies, is due to asymmetry in SIA and vacancy clustering assisted by the large difference in mobilities of SIAs and vacancies. This annealing behavior is unaffected by the dimensionality of SIA migration persists over a broad range of relative mobilities of SIAs and vacancies.« less

Relationship between water quality and macro-scale parameters (land use, erosion, geology, and population density) in the Siminehrood River Basin.

PubMed

Bostanmaneshrad, Farshid; Partani, Sadegh; Noori, Roohollah; Nachtnebel, Hans-Peter; Berndtsson, Ronny; Adamowski, Jan Franklin

2018-10-15

To date, few studies have investigated the simultaneous effects of macro-scale parameters (MSPs) such as land use, population density, geology, and erosion layers on micro-scale water quality variables (MSWQVs). This research focused on an evaluation of the relationship between MSPs and MSWQVs in the Siminehrood River Basin, Iran. In addition, we investigated the importance of water particle travel time (hydrological distance) on this relationship. The MSWQVs included 13 physicochemical and biochemical parameters observed at 15 stations during three seasons. Primary screening was performed by utilizing three multivariate statistical analyses (Pearson's correlation, cluster and discriminant analyses) in seven series of observed data. These series included three separate seasonal data, three two-season data, and aggregated three-season data for investigation of relationships between MSPs and MSWQVs. Coupled data (pairs of MSWQVs and MSPs) repeated in at least two out of three statistical analyses were selected for final screening. The primary screening results demonstrated significant relationships between land use and phosphorus, total solids and turbidity, erosion levels and electrical conductivity, and erosion and total solids. Furthermore, water particle travel time effects were considered through three geographical pattern definitions of distance for each MSP by using two weighting methods. To find effective MSP factors on MSWQVs, a multivariate linear regression analysis was employed. Then, preliminary equations that estimated MSWQVs were developed. The preliminary equations were modified to adaptive equations to obtain the final models. The final models indicated that a new metric, referred to as hydrological distance, provided better MSWQV estimation and water quality prediction compared to the National Sanitation Foundation Water Quality Index. Crown Copyright © 2018. Published by Elsevier B.V. All rights reserved.

A simplified gross primary production and evapotranspiration model for boreal coniferous forests - is a generic calibration sufficient?

NASA Astrophysics Data System (ADS)

Minunno, F.; Peltoniemi, M.; Launiainen, S.; Aurela, M.; Lindroth, A.; Lohila, A.; Mammarella, I.; Minkkinen, K.; Mäkelä, A.

2015-07-01

The problem of model complexity has been lively debated in environmental sciences as well as in the forest modelling community. Simple models are less input demanding and their calibration involves a lower number of parameters, but they might be suitable only at local scale. In this work we calibrated a simplified ecosystem process model (PRELES) to data from multiple sites and we tested if PRELES can be used at regional scale to estimate the carbon and water fluxes of Boreal conifer forests. We compared a multi-site (M-S) with site-specific (S-S) calibrations. Model calibrations and evaluations were carried out by the means of the Bayesian method; Bayesian calibration (BC) and Bayesian model comparison (BMC) were used to quantify the uncertainty in model parameters and model structure. To evaluate model performances BMC results were combined with more classical analysis of model-data mismatch (M-DM). Evapotranspiration (ET) and gross primary production (GPP) measurements collected in 10 sites of Finland and Sweden were used in the study. Calibration results showed that similar estimates were obtained for the parameters at which model outputs are most sensitive. No significant differences were encountered in the predictions of the multi-site and site-specific versions of PRELES with exception of a site with agricultural history (Alkkia). Although PRELES predicted GPP better than evapotranspiration, we concluded that the model can be reliably used at regional scale to simulate carbon and water fluxes of Boreal forests. Our analyses underlined also the importance of using long and carefully collected flux datasets in model calibration. In fact, even a single site can provide model calibrations that can be applied at a wider spatial scale, since it covers a wide range of variability in climatic conditions.

Fundamental parameters of BE UMa revised

NASA Astrophysics Data System (ADS)

Shimanskii, V. V.; Borisov, N. V.; Pozdnyakova, S. A.; Bikmaev, I. F.; Vlasyuk, V. V.; Sakhibullin, N. A.; Spiridonova, O. I.

2008-07-01

We have determined a complete set of parameters for the young pre-cataclysmic variable BE UMa from a comprehensive photometric and spectroscopic analysis using model atmospheres. Our precise photometry and spectroscopy were acquired with the 6-m telescope and Zeiss-1000 telescope of the Special Astrophysical Observatory and the 1.5-m Russian-Turkish telescope at a wide range of orbital phases, including times of primary eclipses.We performed a detailed identification of emission lines of ten elements. At phases of minimum brightness, the spectra reveal absorption lines and molecular bands formed in the secondary’s atmosphere, whose effective temperature was determined to be T {/eff (2)} = 4750 ± 150 K. We have studied the radial-velocity curves of the cool star using lines of various elements. All the curves exhibit the previously predicted distortions due to reflection effects in the close binary. The derived component-mass ratio is q = 0.43 ± 0.09, and the component masses are M 1 = 0.59 ± 0.07 M ⊙ and M 2 = 0.25 ± 0.08 M ⊙. We analyzed the light curves using model atmospheres for irradiated stars; all the parameters of BE UMa were refined. We demonstrate the validity of our modeling of the binary’s spectra at phases of brightness maximum, which provides a good description of the observed intensities of most lines of heavy elements. The abundances of helium and several light elements (C, N, O, Ne, Mg) in the atmosphere of the cool star are probably higher than the solar values. We conclude that the physical characteristics of the primary are in good agreement with evolutionary tracks for planetary-nebula nuclei, and that the secondary is overluminous by a factor of 30 compared to main-sequence stars of the same mass.

Current practice patterns and knowledge among gynecologic surgeons of InterStim® programming after implantation.

PubMed

Hobson, Deslyn T G; Gaskins, Jeremy T; Frazier, LaTisha; Francis, Sean L; Kinman, Casey L; Meriwether, Kate V

2017-10-03

The objective of this study was to describe surgeons' current practices in InterStim® programming after initial implantation and their knowledge of programming parameters. We hypothesized that surgeons performing their own reprogramming would have increased knowledge. We administered a written survey to attendees at the Society of Gynecologic Surgeons Scientific Meeting and analyzed those on which surgeons indicated they offer InterStim® care. The survey queried surgeon characteristics, experience with InterStim® implantation and programming, and clinical opinions regarding reprogramming and tested six knowledge-based questions about programming parameters. Correct response to all six questions was the primary outcome. One hundred and thirty-five of 407 (33%) attendees returned the survey, of which 99 met inclusion criteria. Most respondents (88 of 99; 89%) were between 36 and 60 years, 27 (73%) were women, 76 (77%) practiced in a university setting, and 76 (77%) were trained in Female Pelvic Medicine and Reconstructive Surgery (FPMRS). Surgeons who had InterStim® programming training were more likely to perform their own programming [15/46 (32%) vs 6/47 (13%), p = 0.03]. Most answered all knowledge-based questions correctly (62/90, 69%); no surgeon characteristics were significantly associated with this outcome. Most surgeons cited patient comfort (71/80, 89%) and symptom relief (64/80, 80%) as important factors when reprogramming, but no prevalent themes emerged on how and why surgeons change certain programming parameters. Surgeons who had formal InterStim® programming training are more likely to perform programming themselves. No surgeon characteristic was associated with improved programming knowledge. We found that surgeons prioritize patient comfort and symptoms when deciding to reprogram.

Real-time data acquisition and alerts may reduce reaction time and improve perfusionist performance during cardiopulmonary bypass.

PubMed

Beck, J R; Fung, K; Lopez, H; Mongero, L B; Argenziano, M

2015-01-01

Delayed perfusionist identification and reaction to abnormal clinical situations has been reported to contribute to increased mortality and morbidity. The use of automated data acquisition and compliance safety alerts has been widely accepted in many industries and its use may improve operator performance. A study was conducted to evaluate the reaction time of perfusionists with and without the use of compliance alert. A compliance alert is a computer-generated pop-up banner on a pump-mounted computer screen to notify the user of clinical parameters outside of a predetermined range. A proctor monitored and recorded the time from an alert until the perfusionist recognized the parameter was outside the desired range. Group one included 10 cases utilizing compliance alerts. Group 2 included 10 cases with the primary perfusionist blinded to the compliance alerts. In Group 1, 97 compliance alerts were identified and, in group two, 86 alerts were identified. The average reaction time in the group using compliance alerts was 3.6 seconds. The average reaction time in the group not using the alerts was nearly ten times longer than the group using computer-assisted, real-time data feedback. Some believe that real-time computer data acquisition and feedback improves perfusionist performance and may allow clinicians to identify and rectify potentially dangerous situations. © The Author(s) 2014.

Federal interagency nature‐like fishway passage design guidelines for Atlantic coast diadromous fishes

USGS Publications Warehouse

Turek, James; Haro, Alexander J.; Towler, Brett

2016-01-01

The National Marine Fisheries Service (NMFS), the U.S. Geological Survey (USGS) and the U.S. Fish and Wildlife Service (USFWS) have collaborated to develop passage design guidance for use by engineers and other restoration practitioners considering and designing nature‐like fishways (NLFs). The primary purpose of these guidelines is to provide a summary of existing fish swimming and leaping performance data and the best available scientific information on safe, timely and effective passage for 14 diadromous fish species using Atlantic Coast rivers and streams. These guidelines apply to passage sites where complete barrier removal is not possible. This technical memorandum presents seven key physical design parameters based on the biometrics and swimming mode and performance of each target fishes for application in the design of NLFs addressing passage of a species or an assemblage of these species. The passage parameters include six dimensional guidelines recommended for minimum weir opening width and depth, minimum pool length, width and depth, and maximum channel slope, along with a maximum flow velocity guideline for each species. While these guidelines are targeted for the design of step‐pool NLFs, the information may also have application in the design of other NLF types being considered at passage restoration sites and grade control necessary for infrastructure protection upstream of some dam removals, and in considering passage performance at sites such as natural bedrock features.

A miniature TDCR system dedicated to in-situ activity assay.

PubMed

Johansson, Lena; Bakhshandeiar, Eleanor; Pearce, Andy; Collins, Sean; Orlandini, Pascal; Sephton, John

2014-05-01

In the framework of the European Metrology Research Programme (EMRP), the Joint Research Project MetroFission has a dedicated work package for the development of a portable Triple-to-Double-Coincidence-Ratio (TDCR) system dedicated to in-situ activity measurements of low-energy beta emitters arising from the operation of the next generation of nuclear power plants. In the design phase of the NPL version of the mini-TDCR, a wide range of metrological aspects and detector types was considered. This paper summarizes these aspects of design, in the light of previous experience with the primary TDCR system at NPL. For example, in this miniature version of the TDCR, the optical chamber was simplified and cylindrical geometry was deemed sufficient. The reflectivity of the surface was increased by painted layers of Spectraflect(®), a specially formulated barium sulphate coating with high reflectivity across a wide range of wave lengths including UV. This option was chosen rather than the high performing and more expensive Spectralon(®) material used for the primary NPL TDCR. The miniature TDCR system is intended for on-site monitoring and will not require as high a performance as the primary system. Other factors that were considered included sample changing, light tightness, type of photo detector, method for varying the detection efficiency, shielding and the possible addition of an internal gamma-ray source for determination of the quench parameter of the source. In this version, the sample changing is performed using a piston and an automatic shutter. Significant design effort has been applied to ensure minimal ingress of light from the piston. Efficiency variation is accomplished by increasing the vertical displacement of the vial. Provision has been made to automate this at a later stage. Maximum light transmission to the photo-multiplier tubes is obtained at the "zero" reference height. Validation measurements were successfully performed using four different radionuclides: (3)H, (241)Pu, (63)Ni, and (99)Tc. © 2013 The Authors. Published by Elsevier Ltd All rights reserved.

Evaluation of vocal acoustic and efficiency analysis parameters in medical students and academic teachers with use of iris and diagnoscope specialist software.

PubMed

Zielińska-Bliźniewska, Hanna; Sułkowski, Wiesław J; Pietkiewicz, Piotr; Miłoński, Jarosław; Mazurek, Agnieszka; Olszewski, Jurek

2012-06-01

The aim of this study was to compare the parameters of vocal acoustic and vocal efficiency analyses in medical students and academic teachers with use of the IRIS and DiagnoScope Specialist software and to evaluate their usefulness in prevention and certification of occupational disease. The study group comprised 40 women, including students and employees of the Military Medical Faculty, Medical University of Łodź. After informed consent had been obtained from the participant women, the primary medical history was taken, videolaryngoscopic and stroboscopic examinations were performed and diagnostic vocal acoustic analysis was carried out with the use of the IRIS and Diagno-Scope Specialist software. Based on the results of the performed measurements, the statistical analysis evidenced the compatibility between two software programs, IRIS and DiagnoScope Specialist, with the only exception of the F4 formant. The mean values of vocal acoustic parameters in medical students and academic teachers, obtained by means of the IRIS software, can be used as standards for the female population not yet developed by the producer. When using the DiagnoScope Specialist software, some mean values were higher and some lower than the standards specified by the producer. The study evidenced the compatibility between two measurement software programs, IRIS and DiagnoScope Specialist, except for the F4 formant. It should be noted that the later has advantage over the former since the standard values of vocal acoustic parameters have been worked out by the producer. Moreover, they only slightly departed from the values obtained in our study and may be useful in diagnostics of occupational voice disorders.

The impact of LRP5 polymorphism (rs556442) on calcium homeostasis, bone mineral density, and body composition in Iranian children.

PubMed

Ashouri, Elham; Meimandi, Elham Mahmoodi; Saki, Forough; Dabbaghmanesh, Mohammad Hossein; Omrani, Gholamhossein Ranjbar; Bakhshayeshkaram, Marzieh

2015-11-01

Failure to achieve optimal bone mass in childhood is the primary cause of decreased adult bone mineral density (BMD) and increased bone fragility in later life. Activating and inactivating LRP5 gene mutations has been associated with extreme bone-related phenotypes. Our aim was to investigate the role of LRP5 polymorphism on BMD, mineral biochemical parameters, and body composition in Iranian children. This cross-sectional study was performed on 9-18 years old children (125 boys, 137 girls). The serum level of calcium, phosphorous, alkaline phosphatase, and vitamin D parameters were checked. The body composition and BMD variables were measured by the Hologic system DXA. The rs566442 (V1119V) coding polymorphism in exon 15 of LRP5 was performed using PCR-RFLP method. Linear regression analysis, with adjustment for age, gender, body size parameters, and pubertal status was used to determine the association between LRP5 polymorphism (rs556442) and bone and body composition parameters. The allele frequency of the rs566442 gene was 35.5 % A and 63.9 % G. Our study revealed that LRP5 (rs556442) has not any significant influence on serum calcium, phosphorus, 25OHvitD, and serum alkaline phosphatase (P > 0.05). Total lean mass was greater in GG genotype (P = 0.028). Total body less head area (P = 0.044), spine BMD (P = 0.04), and total femoral BMC (P = 0.049) were lower in AG heterozygote genotype. This study show LRP5 polymorphism may associate with body composition and BMD in Iranian children. However, further investigations should be done to evaluate the role of other polymorphism.

Acoustical characterization and parameter optimization of polymeric noise control materials

NASA Astrophysics Data System (ADS)

Homsi, Emile N.

2003-10-01

The sound transmission loss (STL) characteristics of polymer-based materials are considered. Analytical models that predict, characterize and optimize the STL of polymeric materials, with respect to physical parameters that affect performance, are developed for single layer panel configuration and adapted for layered panel construction with homogenous core. An optimum set of material parameters is selected and translated into practical applications for validation. Sound attenuating thermoplastic materials designed to be used as barrier systems in the automotive and consumer industries have certain acoustical characteristics that vary in function of the stiffness and density of the selected material. The validity and applicability of existing theory is explored, and since STL is influenced by factors such as the surface mass density of the panel's material, a method is modified to improve STL performance and optimize load-bearing attributes. An experimentally derived function is applied to the model for better correlation. In-phase and out-of-phase motion of top and bottom layers are considered. It was found that the layered construction of the co-injection type would exhibit fused planes at the interface and move in-phase. The model for the single layer case is adapted to the layered case where it would behave as a single panel. Primary physical parameters that affect STL are identified and manipulated. Theoretical analysis is linked to the resin's matrix attribute. High STL material with representative characteristics is evaluated versus standard resins. It was found that high STL could be achieved by altering materials' matrix and by integrating design solution in the low frequency range. A suggested numerical approach is described for STL evaluation of simple and complex geometries. In practice, validation on actual vehicle systems proved the adequacy of the acoustical characterization process.

Automatic user customization for improving the performance of a self-paced brain interface system.

PubMed

Fatourechi, Mehrdad; Bashashati, Ali; Birch, Gary E; Ward, Rabab K

2006-12-01

Customizing the parameter values of brain interface (BI) systems by a human expert has the advantage of being fast and computationally efficient. However, as the number of users and EEG channels grows, this process becomes increasingly time consuming and exhausting. Manual customization also introduces inaccuracies in the estimation of the parameter values. In this paper, the performance of a self-paced BI system whose design parameter values were automatically user customized using a genetic algorithm (GA) is studied. The GA automatically estimates the shapes of movement-related potentials (MRPs), whose features are then extracted to drive the BI. Offline analysis of the data of eight subjects revealed that automatic user customization improved the true positive (TP) rate of the system by an average of 6.68% over that whose customization was carried out by a human expert, i.e., by visually inspecting the MRP templates. On average, the best improvement in the TP rate (an average of 9.82%) was achieved for four individuals with spinal cord injury. In this case, the visual estimation of the parameter values of the MRP templates was very difficult because of the highly noisy nature of the EEG signals. For four able-bodied subjects, for which the MRP templates were less noisy, the automatic user customization led to an average improvement of 3.58% in the TP rate. The results also show that the inter-subject variability of the TP rate is also reduced compared to the case when user customization is carried out by a human expert. These findings provide some primary evidence that automatic user customization leads to beneficial results in the design of a self-paced BI for individuals with spinal cord injury.

Comparison of chiller models for use in model-based fault detection

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sreedharan, Priya; Haves, Philip

Selecting the model is an important and essential step in model based fault detection and diagnosis (FDD). Factors that are considered in evaluating a model include accuracy, training data requirements, calibration effort, generality, and computational requirements. The objective of this study was to evaluate different modeling approaches for their applicability to model based FDD of vapor compression chillers. Three different models were studied: the Gordon and Ng Universal Chiller model (2nd generation) and a modified version of the ASHRAE Primary Toolkit model, which are both based on first principles, and the DOE-2 chiller model, as implemented in CoolTools{trademark}, which ismore » empirical. The models were compared in terms of their ability to reproduce the observed performance of an older, centrifugal chiller operating in a commercial office building and a newer centrifugal chiller in a laboratory. All three models displayed similar levels of accuracy. Of the first principles models, the Gordon-Ng model has the advantage of being linear in the parameters, which allows more robust parameter estimation methods to be used and facilitates estimation of the uncertainty in the parameter values. The ASHRAE Toolkit Model may have advantages when refrigerant temperature measurements are also available. The DOE-2 model can be expected to have advantages when very limited data are available to calibrate the model, as long as one of the previously identified models in the CoolTools library matches the performance of the chiller in question.« less

Soybean Physiology Calibration in the Community Land Model

NASA Astrophysics Data System (ADS)

Drewniak, B. A.; Bilionis, I.; Constantinescu, E. M.

2014-12-01

With the large influence of agricultural land use on biophysical and biogeochemical cycles, integrating cultivation into Earth System Models (ESMs) is increasingly important. The Community Land Model (CLM) was augmented with a CLM-Crop extension that simulates the development of three crop types: maize, soybean, and spring wheat. The CLM-Crop model is a complex system that relies on a suite of parametric inputs that govern plant growth under a given atmospheric forcing and available resources. However, the strong nonlinearity of ESMs makes parameter fitting a difficult task. In this study, our goal is to calibrate ten of the CLM-Crop parameters for one crop type, soybean, in order to improve model projection of plant development and carbon fluxes. We used measurements of gross primary productivity, net ecosystem exchange, and plant biomass from AmeriFlux sites to choose parameter values that optimize crop productivity in the model. Calibration is performed in a Bayesian framework by developing a scalable and adaptive scheme based on sequential Monte Carlo (SMC). Our scheme can perform model calibration using very few evaluations and, by exploiting parallelism, at a fraction of the time required by plain vanilla Markov Chain Monte Carlo (MCMC). We present the results from a twin experiment (self-validation) and calibration results and validation using real observations from an AmeriFlux tower site in the Midwestern United States, for the soybean crop type. The improved model will help researchers understand how climate affects crop production and resulting carbon fluxes, and additionally, how cultivation impacts climate.

[Collaborative application of BEPS at different time steps.

PubMed

Lu, Wei; Fan, Wen Yi; Tian, Tian

2016-09-01

BEPSHourly is committed to simulate the ecological and physiological process of vegetation at hourly time steps, and is often applied to analyze the diurnal change of gross primary productivity (GPP), net primary productivity (NPP) at site scale because of its more complex model structure and time-consuming solving process. However, daily photosynthetic rate calculation in BEPSDaily model is simpler and less time-consuming, not involving many iterative processes. It is suitable for simulating the regional primary productivity and analyzing the spatial distribution of regional carbon sources and sinks. According to the characteristics and applicability of BEPSDaily and BEPSHourly models, this paper proposed a method of collaborative application of BEPS at daily and hourly time steps. Firstly, BEPSHourly was used to optimize the main photosynthetic parameters: the maximum rate of carboxylation (V c max ) and the maximum rate of photosynthetic electron transport (J max ) at site scale, and then the two optimized parameters were introduced into BEPSDaily model to estimate regional NPP at regional scale. The results showed that optimization of the main photosynthesis parameters based on the flux data could improve the simulate ability of the model. The primary productivity of different forest types in descending order was deciduous broad-leaved forest, mixed forest, coniferous forest in 2011. The collaborative application of carbon cycle models at different steps proposed in this study could effectively optimize the main photosynthesis parameters V c max and J max , simulate the monthly averaged diurnal GPP, NPP, calculate the regional NPP, and analyze the spatial distribution of regional carbon sources and sinks.

Economic evaluation of a pharmaceutical care program for elderly diabetic and hypertensive patients in primary health care: a 36-month randomized controlled clinical trial.

PubMed

Obreli-Neto, Paulo Roque; Marusic, Srecko; Guidoni, Camilo Molino; Baldoni, André de Oliveira; Renovato, Rogério Dias; Pilger, Diogo; Cuman, Roberto Kenji Nakamura; Pereira, Leonardo Régis Leira

2015-01-01

Most diabetic and hypertensive patients, principally the elderly, do not achieve adequate disease control and consume 5%-15% of annual health care budgets. Previous studies verified that pharmaceutical care is useful for achieving adequate disease control in diabetes and hypertension. To evaluate the economic cost and the incremental cost-effectiveness ratio (ICER) per quality-adjusted life-year (QALY) of pharmaceutical care in the management of diabetes and hypertension in elderly patients in a primary public health care system in a developing country. A 36-month randomized controlled clinical trial was performed with 200 patients who were divided into a control group (n = 100) and an intervention group (n = 100). The control group received the usual care offered by the Primary Health Care Unit (medical and nurse consultations). The intervention group received the usual care plus a pharmaceutical care intervention. The intervention and control groups were compared with regard to the direct costs of health services (i.e., general practitioner, specialist, nurse, and pharmacist appointments; emergency room visits; and drug therapy costs) and the ICER per QALY. These evaluations used the health system perspective. No statistically significant difference was found between the intervention and control groups in total direct health care costs ($281.97 ± $49.73 per patient vs. $212.28 ± $43.49 per patient, respectively; P = 0.089); pharmaceutical care added incremental costs of $69.60 (± $7.90) per patient. The ICER per QALY was $53.50 (95% CI = $51.60-$54.00; monetary amounts are given in U.S. dollars). Every clinical parameter evaluated improved for the pharmaceutical care group, whereas these clinical parameters remained unchanged in the usual care group. The difference in differences (DID) tests indicated that for each clinical parameter, the patients in the intervention group improved more from pre to post than the control group (P < 0.001). While pharmaceutical care did not significantly increase total direct health care costs, significantly improved health outcomes were seen. The mean ICER per QALY gained suggests a favorable cost-effectiveness.

A modified QuEChERS method for the determination of some herbicides in yogurt and milk by high performance liquid chromatography.

PubMed

Li, Na; Lei, Lei; Nian, Li; Zhang, Rui; Wu, Shuting; Ren, Ruibing; Wang, Yeqiang; Zhang, Hanqi; Yu, Aimin

2013-02-15

A modified quick, easy, cheap, effective, rugged, and safe (QuEChERS) method was applied to the extraction of triazines and phenylureas from milk and yogurt. The herbicides was extracted by the mixture of ethyl acetate and n-hexane and cleaned by primary secondary amine (10mg/mL). The frozen-out centrifugation was applied to further remove fatty. The proposed method can achieve efficient extraction and cleanup. Some experimental parameters, such as extraction method, extraction solvent and adsorbent, pH of sample solution, extraction time and amount of primary secondary amine and sodium chloride were investigated and optimized. The precision and absolute recoveries of eight herbicides vary from 0.07 to 5.86% and from 78.9 to 99.9%, respectively. The detection limits for simeton, monuron, chlorotoluron, simetryne, atrazine, karmex, ametryne and propazine range from 0.15 to 0.35 ng/mL. Copyright © 2012 Elsevier B.V. All rights reserved.

Cytoreductive nephrectomy vs medical therapy as initial treatment: a rational approach to the sequence question in metastatic renal cell carcinoma.

PubMed

Spiess, Philippe E; Fishman, Mayer N

2010-10-01

Renal cell carcinoma (RCC) can be considered as two distinct entities: localized and metastatic disease. We conducted a review of the scientific literature published within the past decade pertaining to cytoreductive nephrectomy for metastatic RCC. Retrospective data and historical prospective series have demonstrated the survival benefit of debulking nephrectomy in well-selected RCC patients. New medical therapies, including vascular endothelial growth factor and mTOR pathway blocking drugs, are active biological agents, with survival improvement and potential regression of metastatic and primary tumors. Our current therapeutic challenge is the optimal integration of multimodal therapy consisting of systemic therapy and surgery including cytoreductive nephrectomy, debulking, and metastasectomy. Empiric data to guide this decision are limited. The decision concerning whether medical or surgical therapy should be the primary treatment approach selected must be made on an individual basis, taking into account patient performance status, clinical parameters, and physician expertise and recommendations, thus making each case a unique therapeutic challenge.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kumar, Kamal; Zhang, Yu; Sung, Chi -Jen

We study the influence of blending n-butanol on the ignition delay times of n-heptane and iso-octane, the primary reference fuels for gasoline. The ignition delay times are measured using a rapid compression machine, with an emphasis on the low-to-intermediate temperature conditions. The experiments are conducted at equivalence ratios of 0.4 and 1.0, for a compressed pressure of 20 bar, with the temperatures at the end of compression ranging from 613 K to 979 K. The effect of n-butanol addition on the development of the two-stage ignition characteristics for the two primary reference fuels is also examined. The experimental results aremore » compared to predictions obtained using a detailed chemical kinetic mechanism, which has been obtained by a systematic merger of previously reported base models for the combustion of the individual fuel constituents. In conclusion, a sensitivity analysis on the base, and the merged models, is also performed to understand the dependence of autoignition delay times on the model parameters.« less

Stability analysis of an equilibrium position in the photogravitational Sitnikov problem

NASA Astrophysics Data System (ADS)

Bardin, B. S.; Avdushkin, A. N.

2018-05-01

We deal with the so-called photogravitational Sitnikov problem, that is we consider rectilinear motion of a body of infinitesimal mass in a field of two graviting and radiating primaries, which have equal masses and act on the body with equal repulsive forces of radiation pressure. The body has equilibrium position in the barycenter of the system. In this paper the stability of the equilibrium position is investigated in detail. In particular, by the study of the linearized system we have found in the plane of parameter values the regions of instability. It appears that the instability regions alternate with stability regions and become very narrower when the eccentricity of the primaries orbits approaches to 1. Outside the instability regions we have performed non-linear stability analysis and shown that the stability of the equilibrium position in the sense of Lyapunov takes place both in resonant and non-resonant cases. The results of the study are represented in a form of stability diagram.

A Predictive Model of Anesthesia Depth Based on SVM in the Primary Visual Cortex

PubMed Central

Shi, Li; Li, Xiaoyuan; Wan, Hong

2013-01-01

In this paper, a novel model for predicting anesthesia depth is put forward based on local field potentials (LFPs) in the primary visual cortex (V1 area) of rats. The model is constructed using a Support Vector Machine (SVM) to realize anesthesia depth online prediction and classification. The raw LFP signal was first decomposed into some special scaling components. Among these components, those containing higher frequency information were well suited for more precise analysis of the performance of the anesthetic depth by wavelet transform. Secondly, the characteristics of anesthetized states were extracted by complexity analysis. In addition, two frequency domain parameters were selected. The above extracted features were used as the input vector of the predicting model. Finally, we collected the anesthesia samples from the LFP recordings under the visual stimulus experiments of Long Evans rats. Our results indicate that the predictive model is accurate and computationally fast, and that it is also well suited for online predicting. PMID:24044024

Characterization of drug-eluting stent (DES) materials with cluster secondary ion mass spectrometry (SIMS)

NASA Astrophysics Data System (ADS)

Mahoney, Christine M.; Patwardhan, Dinesh V.; Ken McDermott, M.

2006-07-01

Secondary ion mass spectrometry (SIMS) employing an SF 5+ polyatomic primary ion source was utilized to analyze several materials commonly used in drug-eluting stents (DES). Poly(ethylene- co-vinyl acetate) (PEVA), poly(lactic- co-glycolic acid) (PLGA) and various poly(urethanes) were successfully depth profiled using SF 5+ bombardment. The resultant molecular depth profiles obtained from these polymeric films showed very little degradation in molecular signal as a function of increasing SF 5+ primary ion dose when experiments were performed at low temperatures (signal was maintained for doses up to ˜5 × 10 15 ions/cm 2). Temperature was determined to be an important parameter in both the success of the depth profiles and the mass spectral analysis of the polymers. In addition to the pristine polymer films, paclitaxel (drug released in Taxus™ stent) containing PLGA films were also characterized, where it was confirmed that both drug and polymer signals could be monitored as a function of depth at lower paclitaxel concentrations (10 wt%).

Post-Newtonian Circular Restricted 3-Body Problem: Schwarzschild primaries

NASA Astrophysics Data System (ADS)

Dubeibe, F. L.; Lora-Clavijo, F. D.; González, G. A.

2017-07-01

The restricted three-body problem (RTBP) has been extensively studied to investigate the stability of the solar system, extra-solar subsystems, asteroid capture, and the dynamics of two massive black holes orbited by a sun. In the present work, we study the stability of the planar circular restricted three-body problem in the context of post-Newtonian approximations. First of all, we review the results obtained from the post-Newtonian equations of motion calculated in the framework of the Einstein-Infeld-Hoffmann formalism (EIH). Therefore, using the Fodor-Hoenselers-Perjes formalism (FHP), we have performed an expansion of the gravitational potential for two primaries, deriving a new system of equations of motion, which unlike the EIH-approach, preserves the Jacobian integral of motion. Additionally, we have obtained approximate expressions for the Lagrange points in terms of a mass parameter μ, where it is found that the deviations from the classical regime are larger for the FHP than for the EIH equations.

Non-Aqueous Primary Li-Air Flow Battery and Optimization of its Cathode through Experiment and Modeling.

PubMed

Kim, Byoungsu; Takechi, Kensuke; Ma, Sichao; Verma, Sumit; Fu, Shiqi; Desai, Amit; Pawate, Ashtamurthy S; Mizuno, Fuminori; Kenis, Paul J A

2017-09-22

A primary Li-air battery has been developed with a flowing Li-ion free ionic liquid as the recyclable electrolyte, boosting power capability by promoting superoxide diffusion and enhancing discharge capacity through separately stored discharge products. Experimental and computational tools are used to analyze the cathode properties, leading to a set of parameters that improve the discharge current density of the non-aqueous Li-air flow battery. The structure and configuration of the cathode gas diffusion layers (GDLs) are systematically modified by using different levels of hot pressing and the presence or absence of a microporous layer (MPL). These experiments reveal that the use of thinner but denser MPLs is key for performance optimization; indeed, this leads to an improvement in discharge current density. Also, computational results indicate that the extent of electrolyte immersion and porosity of the cathode can be optimized to achieve higher current density. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Evaluation of olfactory function in adults with primary hypothyroidism.

PubMed

Günbey, Emre; Karlı, Rıfat; Gökosmanoğlu, Feyzi; Düzgün, Berkan; Ayhan, Emre; Atmaca, Hulusi; Ünal, Recep

2015-10-01

Sufficient clinical data are not available on the effect of hypothyroidism on olfactory function in adults. In this study, we aimed to evaluate the olfactory function of adult patients diagnosed with primary hypothyroidism. Forty-five patients aged between 18 and 60 years who were diagnosed with clinical primary hypothyroidism and 45 healthy controls who had normal thyroid function tests were included in the study. Sniffin' Sticks olfactory test results of the 2 groups were compared. The relationships between thyroid function tests and olfactory parameters were evaluated. Odor threshold, identification, and discrimination scores of the hypothyroid group were significantly lower than those of the control group (p < 0.001). A significant positive correlation was detected between free triiodothyronine (FT3) levels and odor threshold, identification, and discrimination scores (p < 0.001). There was no significant relationship between thyroid-stimulating hormone (TSH) or free thyroxine (FT4) levels and olfactory parameters. Our study revealed diminished olfactory function in adults with hypothyroidism. FT3 levels were found to have a more significant relationship with olfactory parameters than TSH or FT4 levels. © 2015 ARS-AAOA, LLC.

SU-F-R-13: Decoding 18F-FDG Uptake Heterogeneity for Primary and Lymphoma Tumors by Using Texture Analysis in PET Images

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ma, C; Yin, Y

Purpose: To explore 18F-FDG uptake heterogeneity of primary tumor and lymphoma tumor by texture features of PET image and quantify the heterogeneity difference between primary tumor and lymphoma tumor. Methods: 18 patients with primary tumor and lymphoma tumor in lung cancer were enrolled. All patients underwent whole-body 18F-FDG PET/CT scans before treatment. Texture features, based on Gray-level Co-occurrence Matrix, second and high order matrices are extracted from code using MATLAB software to quantify 18F-FDG uptake heterogeneity. The relationships of volume between energy, entropy, correlation, homogeneity and contrast were analyzed. Results: For different cases, tumor heterogeneity was not the same. Texturemore » parameters (contrast, entropy, and correlation) of lymphoma were lower than primary tumor. On the contrast, the texture parameters (energy, homogeneity and inverse different moment) of lymphoma were higher than primary tumor. Significantly, correlations were observed between volume and energy (primary, r=−0.194, p=0.441; lymphoma, r=−0.339, p=0.582), homogeneity (primary, r=−0.146, p=0.382; lymphoma, r=−0.193, p=0.44), inverse difference moment (primary, r=−0.14, p=0.374; lymphoma, r=−0.172, p=0.414) and a positive correlation between volume and entropy (primary, r=0.233, p=0.483; lymphoma, r=0.462, p=0.680), contrast (primary, r=0.159, p=0.399; lymphoma, r=0.341, p=0.584), correlation (primary, r=0.027, p=0.165; lymphoma, r=0.046, p=0.215). For the same patient, energy for primary and lymphoma tumor is equal. The volume of lymphoma is smaller than primary tumor, but the homogeneity were higher than primary tumor. Conclusion: This study showed that there were effective heterogeneity differences between primary and lymphoma tumor by FDG-PET image texture analysis.« less

Analysis of heat transfer for unsteady MHD free convection flow of rotating Jeffrey nanofluid saturated in a porous medium

NASA Astrophysics Data System (ADS)

Mohd Zin, Nor Athirah; Khan, Ilyas; Shafie, Sharidan; Alshomrani, Ali Saleh

In this article, the influence of thermal radiation on unsteady magnetohydrodynamics (MHD) free convection flow of rotating Jeffrey nanofluid passing through a porous medium is studied. The silver nanoparticles (AgNPs) are dispersed in the Kerosene Oil (KO) which is chosen as conventional base fluid. Appropriate dimensionless variables are used and the system of equations is transformed into dimensionless form. The resulting problem is solved using the Laplace transform technique. The impact of pertinent parameters including volume fraction φ , material parameters of Jeffrey fluid λ1 , λ , rotation parameter r , Hartmann number Ha , permeability parameter K , Grashof number Gr , Prandtl number Pr , radiation parameter Rd and dimensionless time t on velocity and temperature profiles are presented graphically with comprehensive discussions. It is observed that, the rotation parameter, due to the Coriolis force, tends to decrease the primary velocity but reverse effect is observed in the secondary velocity. It is also observed that, the Lorentz force retards the fluid flow for both primary and secondary velocities. The expressions for skin friction and Nusselt number are also evaluated for different values of emerging parameters. A comparative study with the existing published work is provided in order to verify the present results. An excellent agreement is found.

TCP performance in ATM networks: ABR parameter tuning and ABR/UBR comparisons

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chien Fang; Lin, A.

1996-02-27

This paper explores two issues on TOP performance over ATM networks: ABR parameter tuning and performance comparison of binary mode ABR with enhanced UBR services. Of the fifteen parameters defined for ABR, two parameters dominate binary mode ABR performance: Rate Increase Factor (RIF) and Rate Decrease Factor (RDF). Using simulations, we study the effects of these two parameters on TOP over ABR performance. We compare TOP performance with different ABR parameter settings in terms of through-puts and fairness. The effects of different buffer sizes and LAN/WAN distances are also examined. We then compare TOP performance with the best ABR parametermore » setting with corresponding UBR service enhanced with Early Packet Discard and also with a fair buffer allocation scheme. The results show that TOP performance over binary mode ABR is very sensitive to parameter value settings, and that a poor choice of parameters can result in ABR performance worse than that of the much less expensive UBR-EPD scheme.« less

[Cystatin C as a mortality predictor in a hypertensive population in Extremadura, Spain].

PubMed

Garcia Gallego, Francisco; Robles, Nicolás Roberto; Matias Orozco, Nicolás; Mena, Candido; Cidoncha, Antonio

2015-09-07

Cystatin C has proven to be a useful parameter to evaluate renal and cardiovascular risk. Nevertheless, there are scanty reports on the utility of this test in the Spanish population. We performed a survey in a group of patients followed up in Primary Care settings. Prospective follow up of Primary Care attended patients recruited in 2008 and the first half of 2009. The sample included 142 subjects (mean age 64.2±14.6 years, 59.2% men). In all cases, cystatin C was determined and glomerular filtration rate (GFR) was estimated through the Hoek formula. Serum creatinine was also quantified as it was GFR estimated using CKD-EPI equation. The primary objective was a combination of death and major cardiovascular events incidence. There were 29 events registered (4 of them were deaths) and 9 non cardiovascular deaths. The odds ratio for the primary objective was 5.74 for the last quartile of cystatin C distribution (>1mg/l) (P=.002), while it was 6.44 for cystatin C derived GFR (P=.008) and 5.59 for CKD-EPI estimated GFR (P=.002, Mantel-Haenszel test). Cystatin C showed a good association with general mortality and the incidence of cardiovascular events in the Spanish population. Nevertheless, it was not better than the observed relationship with GFR, estimated from creatinine. Copyright © 2015 Elsevier España, S.L.U. All rights reserved.

Biaxial order parameter in the homologous series of orthogonal bent-core smectic liquid crystals

NASA Astrophysics Data System (ADS)

Sreenilayam, S.; Panarin, Y. P.; Vij, J. K.; Osipov, M.; Lehmann, A.; Tschierske, C.

2013-07-01

The fundamental parameter of the uniaxial liquid crystalline state that governs nearly all of its physical properties is the primary orientational order parameter (S) for the long axes of molecules with respect to the director. The biaxial liquid crystals (LCs) possess biaxial order parameters depending on the phase symmetry of the system. In this paper we show that in the first approximation a biaxial orthogonal smectic phase can be described by two primary order parameters: S for the long axes and C for the ordering of the short axes of molecules. The temperature dependencies of S and C are obtained by the Haller's extrapolation technique through measurements of the optical birefringence and biaxiality on a nontilted polar antiferroelectric (Sm-APA) phase of a homologous series of LCs built from the bent-core achiral molecules. For such a biaxial smectic phase both S and C, particularly the temperature dependency of the latter, are being experimentally determined. Results show that S in the orthogonal smectic phase composed of bent cores is higher than in Sm-A calamatic LCs and C is also significantly large.

In-Flight Calibration Processes for the MMS Fluxgate Magnetometers

NASA Astrophysics Data System (ADS)

Bromund, K. R.; Leinweber, H. K.; Plaschke, F.; Strangeway, R. J.; Magnes, W.; Fischer, D.; Nakamura, R.; Anderson, B. J.; Russell, C. T.; Baumjohann, W.; Chutter, M.; Torbert, R. B.; Le, G.; Slavin, J. A.; Kepko, L.

2015-12-01

The calibration effort for the Magnetospheric Multiscale Mission (MMS) Analog Fluxgate (AFG) and Digital Fluxgate (DFG) magnetometers is a coordinated effort between three primary institutions: University of California, Los Angeles (UCLA); Space Research Institute, Graz, Austria (IWF); and Goddard Space Flight Center (GSFC). Since the successful deployment of all 8 magnetometers on 17 March 2015, the effort to confirm and update the ground calibrations has been underway during the MMS commissioning phase. The in-flight calibration processes evaluate twelve parameters that determine the alignment, orthogonalization, offsets, and gains for all 8 magnetometers using algorithms originally developed by UCLA and the Technical University of Braunschweig and tailored to MMS by IWF, UCLA, and GSFC. We focus on the processes run at GSFC to determine the eight parameters associated with spin tones and harmonics. We will also discuss the processing flow and interchange of parameters between GSFC, IWF, and UCLA. IWF determines the low range spin axis offsets using the Electron Drift Instrument (EDI). UCLA determines the absolute gains and sensor azimuth orientation using Earth field comparisons. We evaluate the performance achieved for MMS and give examples of the quality of the resulting calibrations.

Development of a simulation environment to support intercalibration studies over the Algodones Dunes system

NASA Astrophysics Data System (ADS)

Eon, Rehman S.; Gerace, Aaron D.; Montanaro, Matthew; Ambeau, Brittany L.; McCorkel, Joel T.

2018-01-01

The ability of sensors to detect changes in the Earth's environment is dependent on retrieving radiometrically consistent and calibrated measurements from its surface. Intercalibration provides consistency among satellite instruments and ensures fidelity of scientific information. Intercalibration is especially important for spaceborne satellites without any on-board calibration, as accuracy of instruments is significantly affected by changes that occur postlaunch. To better understand the key parameters that impact the intercalibration process, this paper describes a simulation environment that was developed to support the primary mission of the Algodones Dunes campaign. Specifically, measurements obtained from the campaign were utilized to create a synthetic landscape to assess the feasibility of using the Algodones Dunes system as an intercalibration site for spaceborne instruments. The impact of two key parameters (differing view-angles and temporal offsets between instruments) on the intercalibration process was assessed. Results of these studies indicate that although the accuracy of intercalibration is sensitive to these parameters, proper knowledge of their impact leads to situations that minimize their effect. This paper concludes with a case study that addresses the feasibility of performing intercalibration on the International Space Station's platform to support NASA's CLARREO, the climate absolute radiance and refractivity observatory, mission.

Application of gas sensor arrays in assessment of wastewater purification effects.

PubMed

Guz, Łukasz; Łagód, Grzegorz; Jaromin-Gleń, Katarzyna; Suchorab, Zbigniew; Sobczuk, Henryk; Bieganowski, Andrzej

2014-12-23

A gas sensor array consisting of eight metal oxide semiconductor (MOS) type gas sensors was evaluated for its ability for assessment of the selected wastewater parameters. Municipal wastewater was collected in a wastewater treatment plant (WWTP) in a primary sedimentation tank and was treated in a laboratory-scale sequential batch reactor (SBR). A comparison of the gas sensor array (electronic nose) response to the standard physical-chemical parameters of treated wastewater was performed. To analyze the measurement results, artificial neural networks were used. E-nose-gas sensors array and artificial neural networks proved to be a suitable method for the monitoring of treated wastewater quality. Neural networks used for data validation showed high correlation between the electronic nose readouts and: (I) chemical oxygen demand (COD) (r = 0.988); (II) total suspended solids (TSS) (r = 0.938); (III) turbidity (r = 0.940); (IV) pH (r = 0.554); (V) nitrogen compounds: N-NO3 (r = 0.958), N-NO2 (r = 0.869) and N-NH3 (r = 0.978); (VI) and volatile organic compounds (VOC) (r = 0.987). Good correlation of the abovementioned parameters are observed under stable treatment conditions in a laboratory batch reactor.

Clinical impact of 18 F-FDG positron emission tomography/CT on adenoid cystic carcinoma of the head and neck.

PubMed

Jung, Ji-Hoon; Lee, Sang-Woo; Son, Seung Hyun; Kim, Choon-Young; Lee, Chang-Hee; Jeong, Ju Hye; Jeong, Shin Young; Ahn, Byeong-Cheol; Lee, Jaetae

2017-03-01

The purpose of this retrospective study was to assess the diagnostic value of 18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT and the prognostic value of metabolic PET parameters in patients with adenoid cystic carcinoma of the head and neck (ACCHN). Forty patients with newly diagnosed ACCHN were enrolled in this study. We investigated the diagnostic value of 18 F-FDG PET/CT for detecting and staging compared to conventional CT. Kaplan-Meier survival analysis for progression-free survival (PFS) was performed with clinicopathological factors and metabolic PET parameters. The 18 F-FDG PET/CT showed comparable sensitivity (92.3%) to conventional CT for lesion detection, and changed staging and management plan in 6 patients (15.0%). Lower PFS rates were associated with advanced T classification, advanced TNM classification, high maximum standardized uptake value (SUVmax; >5.1), and high total lesion glycolysis (>40.1) of the primary tumor. The 18 F-FDG PET/CT can provide additional information for initial staging, and metabolic PET parameters may serve as prognostic factors of ACCHN. © 2016 Wiley Periodicals, Inc. Head Neck 39: 447-455, 2017. © 2016 Wiley Periodicals, Inc.

Model-data integration to improve the LPJmL dynamic global vegetation model

NASA Astrophysics Data System (ADS)

Forkel, Matthias; Thonicke, Kirsten; Schaphoff, Sibyll; Thurner, Martin; von Bloh, Werner; Dorigo, Wouter; Carvalhais, Nuno

2017-04-01

Dynamic global vegetation models show large uncertainties regarding the development of the land carbon balance under future climate change conditions. This uncertainty is partly caused by differences in how vegetation carbon turnover is represented in global vegetation models. Model-data integration approaches might help to systematically assess and improve model performances and thus to potentially reduce the uncertainty in terrestrial vegetation responses under future climate change. Here we present several applications of model-data integration with the LPJmL (Lund-Potsdam-Jena managed Lands) dynamic global vegetation model to systematically improve the representation of processes or to estimate model parameters. In a first application, we used global satellite-derived datasets of FAPAR (fraction of absorbed photosynthetic activity), albedo and gross primary production to estimate phenology- and productivity-related model parameters using a genetic optimization algorithm. Thereby we identified major limitations of the phenology module and implemented an alternative empirical phenology model. The new phenology module and optimized model parameters resulted in a better performance of LPJmL in representing global spatial patterns of biomass, tree cover, and the temporal dynamic of atmospheric CO2. Therefore, we used in a second application additionally global datasets of biomass and land cover to estimate model parameters that control vegetation establishment and mortality. The results demonstrate the ability to improve simulations of vegetation dynamics but also highlight the need to improve the representation of mortality processes in dynamic global vegetation models. In a third application, we used multiple site-level observations of ecosystem carbon and water exchange, biomass and soil organic carbon to jointly estimate various model parameters that control ecosystem dynamics. This exercise demonstrates the strong role of individual data streams on the simulated ecosystem dynamics which consequently changed the development of ecosystem carbon stocks and fluxes under future climate and CO2 change. In summary, our results demonstrate challenges and the potential of using model-data integration approaches to improve a dynamic global vegetation model.

The Ma_Miss instrument performance, I: Analysis of rocks powders by Martian VNIR spectrometer

NASA Astrophysics Data System (ADS)

De Angelis, Simone; De Sanctis, Maria Cristina; Ammannito, Eleonora; Carli, Cristian; Di Iorio, Tatiana; Altieri, Francesca

2014-10-01

The ExoMars/Ma_Miss instrument is a miniaturized spectrometer that will observe the Martian subsoil in the visible and near infrared range (VNIR, 0.4-2.2 μm) with high spatial resolution, 120 μm. It will be integrated in the Drilling system of the Pasteur Rover of the ExoMars 2018 mission, and will acquire reflectance spectra of the borehole wall performed by the Drill, at various depths down to 2 m. The laboratory breadboard instrument consists of the main subsystems: illumination system, optical fibres for illumination and signal collection, and optical elements for light focusing. It has been interfaced with a commercial spectrometer, the FieldSpec Pro©. The primary aim of this work is to compare the VNIR measurements and spectral parameters derived from the spectra acquired with the Ma_Miss breadboard and with a second laboratory setup. Reflectance spectra have been acquired on a set of six rock powder samples representative of Martian soil. Nine different grain size ranges of each sample have been measured with the breadboard and five spectral parameters were used to explore the Ma_Miss spectra. Those data were compared with spectra acquired by the FieldSpec Pro® coupled with a goniometer. The analyses of these spectral parameters evidence the correlation between the VNIR continuum slope and the grain size, and the correlation between the reflectance and the grain size; both the parameters tend to decrease as the grain size increases. The trends observed with Ma_Miss breadboard for NIR and VNIR slopes and for the reflectance are clearly consistent with the trends observed with the spectro-goniometer setup, although small differences are seen that can be explained with the different viewing geometries of the two instruments. Ma_Miss proves to have great capabilities for extracting spectroscopic information to constrain the mineralogy and some physical parameters of the analysed material.

24-hour esophageal pH monitoring in children with pathological acid gastroesophageal reflux: primary and secondary to food allergy. Part II. Intraesophageal pH values in proximal channel; preliminary study and control studies--after 1, 2, 4 and 9 years of clinical observation as well as dietary and pharmacological treatment.

PubMed

Semeniuk, J; Kaczmarski, M

2007-01-01

Among 264 children suspected of GERD, acid GER was confirmed in 138 children on the basis of 24-hour pH monitoring. Comparative analysis of parameters of 24-hour intraesophageal pH monitoring with dual-channel probe (in proximal channel) in children with acid GER: primary and secondary to cow milk allergy and/or other food allergy (CMA/FA) diagnosed; comparison of examined values of pH monitoring parameters with regard to duration of the disease (preliminary study and prospective studies--after 1, 2, 4 and 9 years of clinical observation and/or conservative treatment). 264 children suspected of GERD, aged: 1.5-102 months; x = 20.78 +/- 17.23 months, were enrolled in a study. In order to differentiate acid primary GER from GER secondary to CMA/FA in 138 (52.3%) children with GERD immunoallergological tests were performed. Positive result of oral food challenge test confirmed the allergy being the cause of GER. 138 children with pathological acid GER were qualified into two groups: 1 and 2. Group 1--76 patients (55.1%), aged: 4-102 months; x = 25.2 +/- 27.28 months, with pathological primary GER. Group 2--62 patients (44.9%), aged: 4-74 months; x = 21.53 +/- 17.79 months, with pathological GER secondary to CMA/FA. Significant differentiation of the mean values of these parameters between preliminary study and control studies within groups was shown in the case of: number of episodes of acid GER and duration of the longest episode of acid GER, acid GER index: total and supine (proximal channel). Statistical significance (p < 0.05) was higher in group 1, especially during prospective clinical observation and/or conservative treatment. At the same time significant differentiation of the mean values of: number of episodes of acid GER and episodes of acid GER lasting more than 5 minutes and mean values of acid GER index: total and supine was shown between the groups. Statistical significance (p < 0.05) was higher in group 2. The preliminary study of examined children confirmed that values of pH monitoring in proximal channel were comparable to those in distal channel and did not contribute to differentiation of GER into primary and secondary. During prospective clinical observation and/or clinical treatment, on the basis of consecutive measurements, especially the number of episodes of acid GER and episodes of acid GER lasting more than 5 minutes, and also supine acid GER index it was stated that GER secondary to CMA/FA was of wider extent (higher) in comparison with primary GER in these patients.

Regionally and seasonally differentiated primary production in the North Atlantic

NASA Astrophysics Data System (ADS)

Sathyendranath, Shubha; Longhurst, Alan; Caverhill, Carla M.; Platt, Trevor

1995-10-01

A bio-geochemical classification of the N. Atlantic Basin is presented according to which the basin is first divided into four primary algal domains: Polar, West-Wind, Trades and Coastal. These are in turn sub-divided into smaller provinces. The classification is based on differences in the physical environment which are likely to influence regional algal dynamics. The seasonally-differentiated parameters of the photosynthesis-light curve ( P-I curve) and parameters that define the vertical structure in chlorophyll profile are then established for each province, based on an analysis of an archive of over 6000 chlorophyll profiles, and over 1800 P-I curves. These are then combined with satellite-derived chlorophyll data for the N. Atlantic, and information on cloud cover, to compute primary production at the annual scale. using a model that computes spectral transmission of light underwater, and spectral, photosynthetic response of phytoplankton to available light. The results are compared with earlier, satellite-derived, estimates of basin-scale primary production.

Severe Weather Environments in Atmospheric Reanalyses

NASA Astrophysics Data System (ADS)

King, A. T.; Kennedy, A. D.

2017-12-01

Atmospheric reanalyses combine historical observation data using a fixed assimilation scheme to achieve a dynamically coherent representation of the atmosphere. How well these reanalyses represent severe weather environments via proxies is poorly defined. To quantify the performance of reanalyses, a database of proximity soundings near severe storms from the Rapid Update Cycle 2 (RUC-2) model will be compared to a suite of reanalyses including: North American Reanalysis (NARR), European Interim Reanalysis (ERA-Interim), 2nd Modern-Era Retrospective Reanalysis for Research and Applications (MERRA-2), Japanese 55-year Reanalysis (JRA-55), 20th Century Reanalysis (20CR), and Climate Forecast System Reanalysis (CFSR). A variety of severe weather parameters will be calculated from these soundings including: convective available potential energy (CAPE), storm relative helicity (SRH), supercell composite parameter (SCP), and significant tornado parameter (STP). These soundings will be generated using the SHARPpy python module, which is an open source tool used to calculate severe weather parameters. Preliminary results indicate that the NARR and JRA55 are significantly more skilled at producing accurate severe weather environments than the other reanalyses. The primary difference between these two reanalyses and the remaining reanalyses is a significant negative bias for thermodynamic parameters. To facilitate climatological studies, the scope of work will be expanded to compute these parameters for the entire domain and duration of select renalyses. Preliminary results from this effort will be presented and compared to observations at select locations. This dataset will be made pubically available to the larger scientific community, and details of this product will be provided.

Dynamic interactions between hypersonic vehicle aerodynamics and propulsion system performance

NASA Technical Reports Server (NTRS)

Flandro, G. A.; Roach, R. L.; Buschek, H.

1992-01-01

Described here is the development of a flexible simulation model for scramjet hypersonic propulsion systems. The primary goal is determination of sensitivity of the thrust vector and other system parameters to angle of attack changes of the vehicle. Such information is crucial in design and analysis of control system performance for hypersonic vehicles. The code is also intended to be a key element in carrying out dynamic interaction studies involving the influence of vehicle vibrations on propulsion system/control system coupling and flight stability. Simple models are employed to represent the various processes comprising the propulsion system. A method of characteristics (MOC) approach is used to solve the forebody and external nozzle flow fields. This results in a very fast computational algorithm capable of carrying out the vast number of simulation computations needed in guidance, stability, and control studies. The three-dimensional fore- and aft body (nozzle) geometry is characterized by the centerline profiles as represented by a series of coordinate points and body cross-section curvature. The engine module geometry is represented by an adjustable vertical grid to accommodate variations of the field parameters throughout the inlet and combustor. The scramjet inlet is modeled as a two-dimensional supersonic flow containing adjustable sidewall wedges and multiple fuel injection struts. The inlet geometry including the sidewall wedge angles, the number of injection struts, their sweepback relative to the vehicle reference line, and strut cross-section are user selectable. Combustion is currently represented by a Rayleigh line calculation including corrections for variable gas properties; improved models are being developed for this important element of the propulsion flow field. The program generates (1) variation of thrust magnitude and direction with angle of attack, (2) pitching moment and line of action of the thrust vector, (3) pressure and temperature distributions throughout the system, and (4) performance parameters such as thrust coefficient, specific impulse, mass flow rates, and equivalence ratio. Preliminary results are in good agreement with available performance data for systems resembling the NASP vehicle configuration.

Primary α and secondary β relaxation dynamics of meta-toluidine in the liquid state investigated by broadband dielectric spectroscopy

NASA Astrophysics Data System (ADS)

Švajdlenková, H.; Ruff, A.; Lunkenheimer, P.; Loidl, A.; Bartoš, J.

2017-08-01

We report a broadband dielectric spectroscopic (BDS) study on the clustering fragile glass-former meta-toluidine (m-TOL) from 187 K up to 289 K over a wide frequency range of 10-3-109 Hz with focus on the primary α relaxation and the secondary β relaxation above the glass temperature Tg. The broadband dielectric spectra were fitted by using the Havriliak-Negami (HN) and Cole-Cole (CC) models. The β process disappearing at Tβ,disap = 1.12Tg exhibits non-Arrhenius dependence fitted by the Vogel-Fulcher-Tamman-Hesse equation with T0βVFTH in accord with the characteristic differential scanning calorimetry (DSC) limiting temperature of the glassy state. The essential feature of the α process consists in the distinct changes of its spectral shape parameter βHN marked by the characteristic BDS temperatures TB1βHN and TB2βHN. The primary α relaxation times were fitted over the entire temperature and frequency range by several current three-parameter up to six-parameter dynamic models. This analysis reveals that the crossover temperatures of the idealized mode coupling theory model (TcMCT), the extended free volume model (T0EFV), and the two-order parameter (TOP) model (Tmc) are close to TB1βHN, which provides a consistent physical rationalization for the first change of the shape parameter. In addition, the other two characteristic TOP temperatures T0TOP and TA are coinciding with the thermodynamic Kauzmann temperature TK and the second change of the shape parameter at around TB2βHN, respectively. These can be related to the onset of the liquid-like domains in the glassy state or the disappearance of the solid-like domains in the normal liquid state.

Rapid determination of vial heat transfer parameters using tunable diode laser absorption spectroscopy (TDLAS) in response to step-changes in pressure set-point during freeze-drying.

PubMed

Kuu, Wei Y; Nail, Steven L; Sacha, Gregory

2009-03-01

The purpose of this study was to perform a rapid determination of vial heat transfer parameters, that is, the contact parameter K(cs) and the separation distance l(v), using the sublimation rate profiles measured by tunable diode laser absorption spectroscopy (TDLAS). In this study, each size of vial was filled with pure water followed by a freeze-drying cycle using a LyoStar II dryer (FTS Systems) with step-changes of the chamber pressure set-point at to 25, 50, 100, 200, 300, and 400 mTorr. K(cs) was independently determined by nonlinear parameter estimation using the sublimation rates measured at the pressure set-point of 25 mTorr. After obtaining K(cs), the l(v) value for each vial size was determined by nonlinear parameter estimation using the pooled sublimation rate profiles obtained at 25 to 400 mTorr. The vial heat transfer coefficient K(v), as a function of the chamber pressure, was readily calculated, using the obtained K(cs) and l(v) values. It is interesting to note the significant difference in K(v) of two similar types of 10 mL Schott tubing vials, primary due to the geometry of the vial-bottom, as demonstrated by the images of the contact areas of the vial-bottom. (c) 2008 Wiley-Liss, Inc. and the American Pharmacists Association

Whole lesion histogram analysis of meningiomas derived from ADC values. Correlation with several cellularity parameters, proliferation index KI 67, nucleic content, and membrane permeability.

PubMed

Surov, Alexey; Hamerla, Gordian; Meyer, Hans Jonas; Winter, Karsten; Schob, Stefan; Fiedler, Eckhard

2018-09-01

To analyze several histopathological features and their possible correlations with whole lesion histogram analysis derived from ADC maps in meningioma. The retrospective study involved 36 patients with primary meningiomas. For every tumor, the following histogram analysis parameters of apparent diffusion coefficient (ADC) were calculated: ADC mean , ADC max , ADC min , ADC median , ADC mode , ADC percentiles: P10, P25, P75, P90, as well kurtosis, skewness, and entropy. All measures were performed by two radiologists. Proliferation index KI 67, minimal, maximal and mean cell count, total nucleic area, and expression of water channel aquaporin 4 (AQP4) were estimated. Spearman's correlation coefficient was used to analyze associations between investigated parameters. A perfect interobserver agreement for all ADC values (0.84-0.97) was identified. All ADC values correlated inversely with tumor cellularity with the strongest correlation between P10, P25 and mean cell count (-0.558). KI 67 correlated inversely with all ADC values except ADC min . ADC parameters did not correlate with total nucleic area. All ADC values correlated statistically significant with expression of AQP4. ADC histogram analysis is a valid method with an excellent interobserver agreement. Cellularity parameters and proliferation potential are associated with different ADC values. Membrane permeability may play a greater role for water diffusion than cell count and proliferation activity. Copyright © 2018 Elsevier Inc. All rights reserved.

Terminal altitude maximization for Mars entry considering uncertainties

NASA Astrophysics Data System (ADS)

Cui, Pingyuan; Zhao, Zeduan; Yu, Zhengshi; Dai, Juan

2018-04-01

Uncertainties present in the Mars atmospheric entry process may cause state deviations from the nominal designed values, which will lead to unexpected performance degradation if the trajectory is designed merely based on the deterministic dynamic model. In this paper, a linear covariance based entry trajectory optimization method is proposed considering the uncertainties presenting in the initial states and parameters. By extending the elements of the state covariance matrix as augmented states, the statistical behavior of the trajectory is captured to reformulate the performance metrics and path constraints. The optimization problem is solved by the GPOPS-II toolbox in MATLAB environment. Monte Carlo simulations are also conducted to demonstrate the capability of the proposed method. Primary trading performances between the nominal deployment altitude and its dispersion can be observed by modulating the weights on the dispersion penalty, and a compromised result referring to maximizing the 3σ lower bound of the terminal altitude is achieved. The resulting path constraints also show better satisfaction in a disturbed environment compared with the nominal situation.

Characterizing the flow field around ballutes of various geometries

NASA Astrophysics Data System (ADS)

Panko, Jeffrey; Carnasciali, Maria-Isabel

2016-11-01

A ballute combines the performance of large parachutes with the rigidity and design flexibility of aeroshells. Such designs, when optimized, could drastically increase the allowable payload for interplanetary missions associated with high reentry velocities, for which, the current capabilities of thermal protection systems are being reached. Using commercially available software, a CFD investigation into the flow phenomena and performance characteristics of various such designs was conducted in order to determine features which may prove conducive for use in aerocapture missions, a primary application of such technology. Concerns around current ballute designs stem from the aerodynamic heating loads and flow instabilities at reentry velocities and as such, the study revolved around geometries which would provide favorable performance under such environments. Design parameters included: blunt versus sharp bodies, boundary layer control, and turbulence model. Results were monitored for changes in lift to drag ratios (L/D), separation point, vortex shedding, and control authority. Funding for this work, in part, provided by the CT Space Grant Consortium.

Optimization of Dish Solar Collectors with and without Secondary Concentrators

NASA Technical Reports Server (NTRS)

Jaffe, L. D.

1982-01-01

Methods for optimizing parabolic dish solar collectors and the consequent effects of various optical, thermal, mechanical, and cost variables are examined. The most important performance optimization is adjusting the receiver aperture to maximize collector efficiency. Other parameters that can be adjusted to optimize efficiency include focal length, and, if a heat engine is used, the receiver temperature. The efficiency maxima associated with focal length and receiver temperature are relatively broad; it may, accordingly, be desirable to design somewhat away from the maxima. Performance optimization is sensitive to the slope and specularity errors of the concentrator. Other optical and thermal variables affecting optimization are the reflectance and blocking factor of the concentrator, the absorptance and losses of the receiver, and, if a heat engine is used, the shape of the engine efficiency versus temperature curve. Performance may sometimes be improved by use of an additional optical element (a secondary concentrator) or a receiver window if the errors of the primary concentrator are large or the receiver temperature is high.

Metachronous Multiple Primary Malignant Neoplasms of the Stomach and the Breast: Report of Two Cases With Review of Literature

PubMed Central

Karthikeyan, Vilvapathy Senguttuvan; Sistla, Sarath Chandra; Srinivasan, Ramachandran; Basu, Debdatta; Panicker, Lakshmi C.; Ali, Sheik Manwar; Rajkumar, Nagarajan

2014-01-01

Multiple primary malignant neoplasm is the occurrence of a second primary malignancy in the same patient within 6 months of the detection of first primary (synchronous), or 6 months or more after primary detection (metachronous). Multiple primary malignant neoplasms are not very frequently encountered in clinical practice. The relative risk for a second primary malignancy increases by 1.111-fold every month from the detection of the first primary malignancy in any individual. We present 2 patients treated for carcinoma of the breast who developed a metachronous primary malignancy in the stomach to highlight the rare occurrence of multiple primary malignant neoplasms. These tumors were histologically dissimilar, with distinct immunohistochemical parameters. The importance lies in carefully identifying the second primary malignancies, not dismissing them as metastases, and treating them accordingly. PMID:24444270

Factorial experimental design for the culture of human embryonic stem cells as aggregates in stirred suspension bioreactors reveals the potential for interaction effects between bioprocess parameters.

PubMed

Hunt, Megan M; Meng, Guoliang; Rancourt, Derrick E; Gates, Ian D; Kallos, Michael S

2014-01-01

Traditional optimization of culture parameters for the large-scale culture of human embryonic stem cells (ESCs) as aggregates is carried out in a stepwise manner whereby the effect of varying each culture parameter is investigated individually. However, as evidenced by the wide range of published protocols and culture performance indicators (growth rates, pluripotency marker expression, etc.), there is a lack of systematic investigation into the true effect of varying culture parameters especially with respect to potential interactions between culture variables. Here we describe the design and execution of a two-parameter, three-level (3(2)) factorial experiment resulting in nine conditions that were run in duplicate 125-mL stirred suspension bioreactors. The two parameters investigated here were inoculation density and agitation rate, which are easily controlled, but currently, poorly characterized. Cell readouts analyzed included fold expansion, maximum density, and exponential growth rate. Our results reveal that the choice of best case culture parameters was dependent on which cell property was chosen as the primary output variable. Subsequent statistical analyses via two-way analysis of variance indicated significant interaction effects between inoculation density and agitation rate specifically in the case of exponential growth rates. Results indicate that stepwise optimization has the potential to miss out on the true optimal case. In addition, choosing an optimum condition for a culture output of interest from the factorial design yielded similar results when repeated with the same cell line indicating reproducibility. We finally validated that human ESCs remain pluripotent in suspension culture as aggregates under our optimal conditions and maintain their differentiation capabilities as well as a stable karyotype and strong expression levels of specific human ESC markers over several passages in suspension bioreactors.

Evaluation of changes in perfusion defect and left ventricular systolic function using Tc-99m Tetrofosmin single photon emission computed tomography over 3 month period in patients of Acute Myocardial Infarction undergoing primary angioplasty.

PubMed

Kumar, Avs Anil; Kumar, P G; Swami, Ajay; Dinker, Yateendra

2018-01-01

After a primary transluminal coronary angioplasty (PTCA) following AMI (acute myocardial infarction), the perfusion defect and LV (left ventricular) function recover/change over a period of time. The analysis immediately after the procedure may not be true depiction of the exact success of the procedure. There is varying and scanty information available on the natural course of changes in these parameters after a successful PTCA. We hypothesized that majority of change occurs at 3-4 month period. Hence, we undertook this study on the natural course of recovery/changes occurring in perfusion defect size and LV function in first 3 months after primary angioplasty MATERIAL AND METHODS: 30 consecutive cases of first AMI who were taken up for Primary angioplasty were enrolled into the study. Resting MPI(Myocardial perfusion imaging) was done within 24-72 hrs of admission using Tc-99m-Tetrofosmin and after 10-14 weeks. Analysis of LVEF (left ventricular ejection fraction), summed segmental score and extent of perfusion defect was done. Images were processed using autocardiac software of emory tool box and quantification was done using QPS (quantitative perfusion SPECT) and QGS (qualitative perfusion SPECT) softwares. 20 segment scoring method was used for quantification on bull's eye images. Student t test (two tailed, dependent) was used to find the significance of study parameters on continuous scale within each group. Effect size was computed to find the effect. Pearson correlation between perfusion defect and LVEF was performed at acute stage and after 10-14 weeks. The average acute perfusion defect extent was 19.76 ± 12.89% which after 3months became 16.79 ± 12.61%. The summed segmental score changed from 14.31 ± 10.58 to 11.38 ± 10.03 and LVEF improved from 48.40 ± 13.15% to 53.37 ± 12.8%. There was significant improvement in LVEF from acute setting to 10-14 weeks (p = 0.001). There was significant lowering of summed score (p = 0.007). Perfusion defect size showed significant reduction (p = 0.030). Three patients showed deterioration in perfusion defect size and in summed score with reduction in LVEF. Four patients had no change in any of the parameters. Correlation between perfusion defect and LVEF was strong both at baseline (r = -0.705, p < 0.001) and after 10-18 weeks (r = -0.766, p < 0.001). The changes we found in 3 months are similar to earlier studies and also to studies using follow up at 6 months to 1 year. We feel that 3 months is a good enough time to accurately assess the success of primary angioplasty.

Effects of carrying a backpack in a symmetrical manner on the shape of the feet.

PubMed

Drzał-Grabiec, Justyna; Snela, Sławomir; Rachwał, Maciej; Rykała, Justyna; Podgórska, Justyna

2013-01-01

The aim of this study was to assess changes in the shape of the feet while carrying a backpack constituting 10% of a child's weight. It was an observational, cross-sectional study involving 118 primary school children aged 11-13 years. Selected parameters of foot shape were assessed in both a normal position and with a backpack using podoscopy and a CQ-ST examination device. The study revealed significant differences in the length and width of the right and left feet between assessments. Moreover, the longitudinal arch of the foot was significantly lowered and deformity of the great toe was reported. Carrying a backpack constituting 10% of a child's weight results in lowering of the longitudinal and traverse arches of the feet and advanced toe deformities. We performed an observational, cross-sectional study examining the effect of carrying a backpack constituting 10% of a child's weight on parameters of foot shape and observed significant lowering of the longitudinal and traverse arches of the feet and advanced toe deformities.

Analysis of Heat Transfers inside Counterflow Plate Heat Exchanger Augmented by an Auxiliary Fluid Flow

PubMed Central

Khaled, A.-R. A.

2014-01-01

Enhancement of heat transfers in counterflow plate heat exchanger due to presence of an intermediate auxiliary fluid flow is investigated. The intermediate auxiliary channel is supported by transverse conducting pins. The momentum and energy equations for the primary fluids are solved numerically and validated against a derived approximate analytical solution. A parametric study including the effect of the various plate heat exchanger, and auxiliary channel dimensionless parameters is conducted. Different enhancement performance indicators are computed. The various trends of parameters that can better enhance heat transfer rates above those for the conventional plate heat exchanger are identified. Large enhancement factors are obtained under fully developed flow conditions. The maximum enhancement factors can be increased by above 8.0- and 5.0-fold for the step and exponential distributions of the pins, respectively. Finally, counterflow plate heat exchangers with auxiliary fluid flows are recommended over the typical ones if these flows can be provided with the least cost. PMID:24719572

Analysis of heat transfers inside counterflow plate heat exchanger augmented by an auxiliary fluid flow.

PubMed

Khaled, A-R A

2014-01-01

Enhancement of heat transfers in counterflow plate heat exchanger due to presence of an intermediate auxiliary fluid flow is investigated. The intermediate auxiliary channel is supported by transverse conducting pins. The momentum and energy equations for the primary fluids are solved numerically and validated against a derived approximate analytical solution. A parametric study including the effect of the various plate heat exchanger, and auxiliary channel dimensionless parameters is conducted. Different enhancement performance indicators are computed. The various trends of parameters that can better enhance heat transfer rates above those for the conventional plate heat exchanger are identified. Large enhancement factors are obtained under fully developed flow conditions. The maximum enhancement factors can be increased by above 8.0- and 5.0-fold for the step and exponential distributions of the pins, respectively. Finally, counterflow plate heat exchangers with auxiliary fluid flows are recommended over the typical ones if these flows can be provided with the least cost.

Sample size calculation in economic evaluations.

PubMed

Al, M J; van Hout, B A; Michel, B C; Rutten, F F

1998-06-01

A simulation method is presented for sample size calculation in economic evaluations. As input the method requires: the expected difference and variance of costs and effects, their correlation, the significance level (alpha) and the power of the testing method and the maximum acceptable ratio of incremental effectiveness to incremental costs. The method is illustrated with data from two trials. The first compares primary coronary angioplasty with streptokinase in the treatment of acute myocardial infarction, in the second trial, lansoprazole is compared with omeprazole in the treatment of reflux oesophagitis. These case studies show how the various parameters influence the sample size. Given the large number of parameters that have to be specified in advance, the lack of knowledge about costs and their standard deviation, and the difficulty of specifying the maximum acceptable ratio of incremental effectiveness to incremental costs, the conclusion of the study is that from a technical point of view it is possible to perform a sample size calculation for an economic evaluation, but one should wonder how useful it is.

Nanodosimetric track structure in homogeneous extended beams.

PubMed

Conte, V; Moro, D; Colautti, P; Grosswendt, B

2015-09-01

Physical aspects of particle track structure are important in determining the induction of clustered damage in relevant subcellular structures like the DNA and higher-order genomic structures. The direct measurement of track-structure properties of ionising radiation is feasible today by counting the number of ionisations produced inside a small gas volume. In particular, the so-called track-nanodosimeter, installed at the TANDEM-ALPI accelerator complex of LNL, measures ionisation cluster-size distributions in a simulated subcellular structure of dimensions 20 nm, corresponding approximately to the diameter of the chromatin fibre. The target volume is irradiated by pencil beams of primary particles passing at specified impact parameter. To directly relate these measured track-structure data to radiobiological measurements performed in broad homogeneous particle beams, these data can be integrated over the impact parameter. This procedure was successfully applied to 240 MeV carbon ions and compared with Monte Carlo simulations for extended fields. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

RTM: Cost-effective processing of composite structures

NASA Technical Reports Server (NTRS)

Hasko, Greg; Dexter, H. Benson

1991-01-01

Resin transfer molding (RTM) is a promising method for cost effective fabrication of high strength, low weight composite structures from textile preforms. In this process, dry fibers are placed in a mold, resin is introduced either by vacuum infusion or pressure, and the part is cured. RTM has been used in many industries, including automotive, recreation, and aerospace. Each of the industries has different requirements of material strength, weight, reliability, environmental resistance, cost, and production rate. These requirements drive the selection of fibers and resins, fiber volume fractions, fiber orientations, mold design, and processing equipment. Research is made into applying RTM to primary aircraft structures which require high strength and stiffness at low density. The material requirements are discussed of various industries, along with methods of orienting and distributing fibers, mold configurations, and processing parameters. Processing and material parameters such as resin viscosity, perform compaction and permeability, and tool design concepts are discussed. Experimental methods to measure preform compaction and permeability are presented.

Guidelines for Developing Spacecraft Structural Requirements: A Thermal and Environmental Perspective

NASA Technical Reports Server (NTRS)

Holladay, Jon; Day, Greg; Gill, Larry

2004-01-01

Spacecraft are typically designed with a primary focus on weight in order to meet launch vehicle performance parameters. However, for pressurized and/or man-rated spacecraft, it is also necessary to have an understanding of the vehicle operating environments to properly size the pressure vessel. Proper sizing of the pressure vessel requires an understanding of the space vehicle's life cycle and compares the physical design optimization (weight and launch "cost") to downstream operational complexity and total life cycle cost. This paper will provide an overview of some major environmental design drivers and provide examples for calculating the optimal design pressure versus a selected set of design parameters related to thermal and environmental perspectives. In addition, this paper will provide a generic set of cracking pressures for both positive and negative pressure relief valves that encompasses worst case environmental effects for a variety of launch / landing sites. Finally, several examples are included to highlight pressure relief set points and vehicle weight impacts for a selected set of orbital missions.

Diagnostic Capability of Peripapillary Retinal Volume Measurements in Glaucoma.

PubMed

Simavli, Huseyin; Poon, Linda Yi-Chieh; Que, Christian J; Liu, Yingna; Akduman, Mustafa; Tsikata, Edem; de Boer, Johannes F; Chen, Teresa C

2017-06-01

To determine the diagnostic capability of spectral domain optical coherence tomography peripapillary retinal volume (RV) measurements. A total of 156 patients, 89 primary open-angle glaucoma and 67 normal subjects, were recruited. Spectral domain optical coherence tomography peripapillary RV was calculated for 4 quadrants using 3 annuli of varying scan circle diameters: outer circumpapillary annuli of circular grids 1, 2, and 3 (OCA1, OCA2, OCA3). Area under the receiver operating characteristic curves and pairwise comparisons of receiver operating characteristic (ROC) curves were performed to determine which quadrants were best for diagnosing primary open-angle glaucoma. The pairwise comparisons of the best ROC curves for RV and retinal nerve fiber layer (RNFL) were performed. The artifact rates were analyzed. Pairwise comparisons showed that the smaller annuli OCA1 and OCA2 had better diagnostic performance than the largest annulus OCA3 (P<0.05 for all quadrants). OCA1 and OCA2 had similar diagnostic performance, except for the inferior quadrant which was better for OCA1 (P=0.0033). The pairwise comparisons of the best ROC curves for RV and RNFL were not statistically significant. RV measurements had lower rates of artifacts at 7.4% while RNFL measurements had higher rates at 42.9%. Peripapillary RV measurements have excellent ability for diagnosing not only glaucoma patients but also a subset of early glaucoma patients. The inferior quadrant of peripapillary annulus OCA1 demonstrated the best diagnostic capability for both glaucoma and early glaucoma. The diagnostic ability of RV is comparable with that of RNFL parameters in glaucoma but with lower artifact rates.

An assessment of phytoplankton primary productivity in the Arctic Ocean from satellite ocean color/in situ chlorophyll‐a based models

PubMed Central

Matrai, Patricia A.; Friedrichs, Marjorie A. M.; Saba, Vincent S.; Antoine, David; Ardyna, Mathieu; Asanuma, Ichio; Babin, Marcel; Bélanger, Simon; Benoît‐Gagné, Maxime; Devred, Emmanuel; Fernández‐Méndez, Mar; Gentili, Bernard; Hirawake, Toru; Kang, Sung‐Ho; Kameda, Takahiko; Katlein, Christian; Lee, Sang H.; Lee, Zhongping; Mélin, Frédéric; Scardi, Michele; Smyth, Tim J.; Tang, Shilin; Turpie, Kevin R.; Waters, Kirk J.; Westberry, Toby K.

2015-01-01

Abstract We investigated 32 net primary productivity (NPP) models by assessing skills to reproduce integrated NPP in the Arctic Ocean. The models were provided with two sources each of surface chlorophyll‐a concentration (chlorophyll), photosynthetically available radiation (PAR), sea surface temperature (SST), and mixed‐layer depth (MLD). The models were most sensitive to uncertainties in surface chlorophyll, generally performing better with in situ chlorophyll than with satellite‐derived values. They were much less sensitive to uncertainties in PAR, SST, and MLD, possibly due to relatively narrow ranges of input data and/or relatively little difference between input data sources. Regardless of type or complexity, most of the models were not able to fully reproduce the variability of in situ NPP, whereas some of them exhibited almost no bias (i.e., reproduced the mean of in situ NPP). The models performed relatively well in low‐productivity seasons as well as in sea ice‐covered/deep‐water regions. Depth‐resolved models correlated more with in situ NPP than other model types, but had a greater tendency to overestimate mean NPP whereas absorption‐based models exhibited the lowest bias associated with weaker correlation. The models performed better when a subsurface chlorophyll‐a maximum (SCM) was absent. As a group, the models overestimated mean NPP, however this was partly offset by some models underestimating NPP when a SCM was present. Our study suggests that NPP models need to be carefully tuned for the Arctic Ocean because most of the models performing relatively well were those that used Arctic‐relevant parameters. PMID:27668139

Development of high-performance printed organic field-effect transistors and integrated circuits.

PubMed

Xu, Yong; Liu, Chuan; Khim, Dongyoon; Noh, Yong-Young

2015-10-28

Organic electronics is regarded as an important branch of future microelectronics especially suited for large-area, flexible, transparent, and green devices, with their low cost being a key benefit. Organic field-effect transistors (OFETs), the primary building blocks of numerous expected applications, have been intensively studied, and considerable progress has recently been made. However, there are still a number of challenges to the realization of high-performance OFETs and integrated circuits (ICs) using printing technologies. Therefore, in this perspective article, we investigate the main issues concerning developing high-performance printed OFETs and ICs and seek strategies for further improvement. Unlike many other studies in the literature that deal with organic semiconductors (OSCs), printing technology, and device physics, our study commences with a detailed examination of OFET performance parameters (e.g., carrier mobility, threshold voltage, and contact resistance) by which the related challenges and potential solutions to performance development are inspected. While keeping this complete understanding of device performance in mind, we check the printed OFETs' components one by one and explore the possibility of performance improvement regarding device physics, material engineering, processing procedure, and printing technology. Finally, we analyze the performance of various organic ICs and discuss ways to optimize OFET characteristics and thus develop high-performance printed ICs for broad practical applications.

Impact of Instructional Resources on Mathematics Performance of Learners with Dyscalculia in Integrated Primary Schools, Arusha City, Tanzania

ERIC Educational Resources Information Center

Yusta, Nyudule; Karugu, Geoffrey; Muthee, Jessica; Tekle, Tesfu

2016-01-01

Learners with dyscalculia in the integrated primary schools in Arusha have been performing poorly in the Primary School Leaving Examination (PSLE). Thus, the journal sought to investigate the impact of instructional resources on mathematics performance of learners with dyscalculia in integrated primary schools found in Arusha city, Tanzania. The…

Modelling size-fractionated primary production in the Atlantic Ocean from remote sensing

NASA Astrophysics Data System (ADS)

Brewin, Robert J. W.; Tilstone, Gavin H.; Jackson, Thomas; Cain, Terry; Miller, Peter I.; Lange, Priscila K.; Misra, Ankita; Airs, Ruth L.

2017-11-01

Marine primary production influences the transfer of carbon dioxide between the ocean and atmosphere, and the availability of energy for the pelagic food web. Both the rate and the fate of organic carbon from primary production are dependent on phytoplankton size. A key aim of the Atlantic Meridional Transect (AMT) programme has been to quantify biological carbon cycling in the Atlantic Ocean and measurements of total primary production have been routinely made on AMT cruises, as well as additional measurements of size-fractionated primary production on some cruises. Measurements of total primary production collected on the AMT have been used to evaluate remote-sensing techniques capable of producing basin-scale estimates of primary production. Though models exist to estimate size-fractionated primary production from satellite data, these have not been well validated in the Atlantic Ocean, and have been parameterised using measurements of phytoplankton pigments rather than direct measurements of phytoplankton size structure. Here, we re-tune a remote-sensing primary production model to estimate production in three size fractions of phytoplankton (<2 μm, 2-10 μm and >10 μm) in the Atlantic Ocean, using measurements of size-fractionated chlorophyll and size-fractionated photosynthesis-irradiance experiments conducted on AMT 22 and 23 using sequential filtration-based methods. The performance of the remote-sensing technique was evaluated using: (i) independent estimates of size-fractionated primary production collected on a number of AMT cruises using 14C on-deck incubation experiments and (ii) Monte Carlo simulations. Considering uncertainty in the satellite inputs and model parameters, we estimate an average model error of between 0.27 and 0.63 for log10-transformed size-fractionated production, with lower errors for the small size class (<2 μm), higher errors for the larger size classes (2-10 μm and >10 μm), and errors generally higher in oligotrophic waters. Application to satellite data in 2007 suggests the contribution of cells <2 μm and >2 μm to total primary production is approximately equal in the Atlantic Ocean.

The correlation between NK cell and liver function in patients with primary hepatocellular carcinoma.

PubMed

Sha, Wei Hong; Zeng, Xiao Hui; Min, Lu

2014-05-01

This study aimed to detect the expression of natural killer (NK) cell receptor natural killer group 2D (NKG2D) in the peripheral blood of patients with primary hepatocellular carcinoma and to discuss the correlation between NK cell cytotoxicity and liver function. The number of NK cells and the expression of NK cell receptor NKG2D in peripheral blood were determined by flow cytometry in patients with primary hepatocellular carcinoma, hepatitis B cirrhosis, chronic hepatitis B, and healthy controls. When compared with patients in the healthy and the chronic hepatitis B groups, the primary hepatocellular carcinoma group showed significant decreases in all parameters, including the cytotoxicity of NK cells on K562 cells, expression rate of NKG2D in NK cells, number of NKG2D(+) NK cells, expression level of NKG2D, and number of NK cells (p<0.05). The activity of NK cells showed a positive correlation, whereas the Child-Pugh scores in the primary hepatocellular carcinoma and the hepatitis B cirrhosis groups showed a negative correlation with all parameters detected above. The decrease of NK cell activity in patients with primary hepatocellular carcinoma is closely related to their lower expression of NKG2D. Liver function affects the expression of NKG2D and the activity of NK cells.

Suppression of Metastasis by Primary Tumor and Acceleration of Metastasis Following Primary Tumor Resection: A Natural Law?

PubMed

Hanin, Leonid; Rose, Jason

2018-03-01

We study metastatic cancer progression through an extremely general individual-patient mathematical model that is rooted in the contemporary understanding of the underlying biomedical processes yet is essentially free of specific biological assumptions of mechanistic nature. The model accounts for primary tumor growth and resection, shedding of metastases off the primary tumor and their selection, dormancy and growth in a given secondary site. However, functional parameters descriptive of these processes are assumed to be essentially arbitrary. In spite of such generality, the model allows for computing the distribution of site-specific sizes of detectable metastases in closed form. Under the assumption of exponential growth of metastases before and after primary tumor resection, we showed that, regardless of other model parameters and for every set of site-specific volumes of detected metastases, the model-based likelihood-maximizing scenario is always the same: complete suppression of metastatic growth before primary tumor resection followed by an abrupt growth acceleration after surgery. This scenario is commonly observed in clinical practice and is supported by a wealth of experimental and clinical studies conducted over the last 110 years. Furthermore, several biological mechanisms have been identified that could bring about suppression of metastasis by the primary tumor and accelerated vascularization and growth of metastases after primary tumor resection. To the best of our knowledge, the methodology for uncovering general biomedical principles developed in this work is new.

[Immunologic parameters in pericholangitis and primary sclerosing cholangitis with and without ulcerative colitis].

PubMed

Hopf, U; Riecken, E O; Zeitz, M; Eckhardt, R; Lobeck, H; Malchus, R; Möller, B

1983-10-07

Immunological parameters and histocompatibility antigens (HLA) were determined in seven patients with non-bacterial cholangitis. Four patients had pericholangitis and ulcerative colitis, three had primary sclerosing cholangitis, one of these with ulcerative colitis. All 7 patients had antinuclear antibodies; however, there were no antibodies against DNA, against mitochondria or liver membrane antigens. One patient had low-titre rheuma factors. Immunoglobulins G, A and M and complement components C3 and C4 were mostly in the normal range. HLA constellation was positive for B8 in 6 patients. These were male patients with disease manifestations between the 12th and 45th year of life. The results support the concept that pericholangitis and primary sclerosing cholangitis with or without ulcerative colitis are related hepatological disease entities with an immunological pathogenesis and an underlying genetical determination.

Fractal basins of attraction in the restricted four-body problem when the primaries are triaxial rigid bodies

NASA Astrophysics Data System (ADS)

Suraj, Md Sanam; Asique, Md Chand; Prasad, Umakant; Hassan, M. R.; Shalini, Kumari

2017-11-01

The planar equilateral restricted four-body problem, formulated on the basis of Lagrange's triangular solutions is used to determine the existence and locations of libration points and the Newton-Raphson basins of convergence associated with these libration points. We have supposed that all the three primaries situated on the vertices of an equilateral triangle are triaxial rigid bodies. This paper also deals with the effect of these triaxiality parameters on the regions of motion where the test particle is free to move. Further, the regions on the configuration plane filled by the basins of attraction are determined by using the multivariate version of the Newton-Raphson iterative system. The numerical study reveals that the triaxiality of the primaries is one of the most influential parameters in the four-body problem.

Surgical Treatment of Metastatic Ovarian Tumors From Extragenital Primary Sites.

PubMed

Sal, Veysel; Demirkiran, Fuat; Topuz, Samet; Kahramanoglu, Ilker; Yalcin, Ibrahim; Bese, Tugan; Sozen, Hamdullah; Tokgozoglu, Nedim; Salihoglu, Yavuz; Turan, Hasan; Iyibozkurt, Cem; Kolomuc, Tugba; Sofiyeva, Nigar; Berkman, Sinan; Arvas, Macit

2016-05-01

The purpose of this study was to investigate the outcomes and prognostic factors of metastasectomy in patients with metastatic ovarian tumors from extragenital primary sites. All patients with pathologically confirmed metastatic ovarian tumors between January 1997 and June 2015 were included in this study. A total of 131 patients were identified. The data were obtained from the patients' medical records. Clinicopathological features were evaluated by both univariate and multivariate analyses. The primary sites were colorectal region (53.4%), stomach (26%), and breast (13%). Preoperative serum CA 125 and CA 19-9 levels were elevated in 29.4% and 39.8% of the patients, respectively. Cytoreductive surgery was performed in 41.2% of the patients. Seventy-three (55.7%) patients had no residual disease after surgery. Sixty-six (49.6%) patients had combined metastases at the time of the surgery to sites including the liver, pancreas, lung, bone, lymph nodes, bladder, or the intestine. With a median follow-up of 33 months, the median survival time was 22 months. The estimated 5-year survival probability is 0.26. On univariate analysis, primary cancer site, combined metastasis outside the ovaries, residual disease, preoperative serum CA 125 and CA 19-9 levels, and histologic type were significant parameters for overall survival. Furthermore, residual disease, preoperative serum CA 19-9 level, and primary cancer site were found to be independent prognostic factors on multivariate analysis. The most common primary sites for ovarian metastasis are gastrointestinal tract. Metastasectomy may have beneficial effects on survival, especially if the residual disease is less than 5 mm. Prospective studies warranted to evaluate the value of metastasectomy in patients with ovarian metastasis.

Correlation of standardized uptake value and apparent diffusion coefficient in integrated whole-body PET/MRI of primary and recurrent cervical cancer.

PubMed

Grueneisen, Johannes; Beiderwellen, Karsten; Heusch, Philipp; Buderath, Paul; Aktas, Bahriye; Gratz, Marcel; Forsting, Michael; Lauenstein, Thomas; Ruhlmann, Verena; Umutlu, Lale

2014-01-01

To evaluate a potential correlation of the maximum standard uptake value (SUVmax) and the minimum apparent diffusion coefficient (ADCmin) in primary and recurrent cervical cancer based on integrated PET/MRI examinations. 19 consecutive patients (mean age 51.6 years; range 30-72 years) with histopathologically confirmed primary cervical cancer (n = 9) or suspected tumor recurrence (n = 10) were prospectively enrolled for an integrated PET/MRI examination. Two radiologists performed a consensus reading in random order, using a dedicated post-processing software. Polygonal regions of interest (ROI) covering the entire tumor lesions were drawn into PET/MR images to assess SUVmax and into ADC parameter maps to determine ADCmin values. Pearson's correlation coefficients were calculated to assess a potential correlation between the mean values of ADCmin and SUVmax. In 15 out of 19 patients cervical cancer lesions (n = 12) or lymph node metastases (n = 42) were detected. Mean SUVmax (12.5 ± 6.5) and ADCmin (644.5 ± 179.7 × 10(-5) mm2/s) values for all assessed tumor lesions showed a significant but weak inverse correlation (R = -0.342, p < 0.05). When subdivided in primary and recurrent tumors, primary tumors and associated primary lymph node metastases revealed a significant and strong inverse correlation between SUVmax and ADCmin (R = -0.692, p < 0.001), whereas recurrent cancer lesions did not show a significant correlation. These initial results of this emerging hybrid imaging technique demonstrate the high diagnostic potential of simultaneous PET/MR imaging for the assessment of functional biomarkers, revealing a significant and strong correlation of tumor metabolism and higher cellularity in cervical cancer lesions.

Aerodynamic characteristics of a large-scale semispan model with a swept wing and an augmented jet flap with hypermixing nozzles. [Ames 40- by 80-Foot Wind Tunnel and Static Test Facility

NASA Technical Reports Server (NTRS)

Aiken, T. N.; Falarski, M. D.; Koenin, D. G.

1979-01-01

The aerodynamic characteristics of the augmentor wing concept with hypermixing primary nozzles were investigated. A large-scale semispan model in the Ames 40- by 80-Foot Wind Tunnel and Static Test Facility was used. The trailing edge, augmentor flap system occupied 65% of the span and consisted of two fixed pivot flaps. The nozzle system consisted of hypermixing, lobe primary nozzles, and BLC slot nozzles at the forward inlet, both sides and ends of the throat, and at the aft flap. The entire wing leading edge was fitted with a 10% chord slat and a blowing slot. Outboard of the flap was a blown aileron. The model was tested statically and at forward speed. Primary parameters and their ranges included angle of attack from -12 to 32 degrees, flap angles of 20, 30, 45, 60 and 70 degrees, and deflection and diffuser area ratios from 1.16 to 2.22. Thrust coefficients ranged from 0 to 2.73, while nozzle pressure ratios varied from 1.0 to 2.34. Reynolds number per foot varied from 0 to 1.4 million. Analysis of the data indicated a maximum static, gross augmentation of 1.53 at a flap angle of 45 degrees. Analysis also indicated that the configuration was an efficient powered lift device and that the net thrust was comparable with augmentor wings of similar static performance. Performance at forward speed was best at a diffuser area ratio of 1.37.

Heat and mass transfer scale-up issues during freeze-drying, III: control and characterization of dryer differences via operational qualification tests.

PubMed

Rambhatla, S; Tchessalov, S; Pikal, Michael J

2006-04-21

The objective of this research was to estimate differences in heat and mass transfer between freeze dryers due to inherent design characteristics using data obtained from sublimation tests. This study also aimed to provide guidelines for convenient scale-up of the freeze-drying process. Data obtained from sublimation tests performed on laboratory-scale, pilot, and production freeze dryers were used to evaluate various heat and mass transfer parameters: nonuniformity in shelf surface temperatures, resistance of pipe, refrigeration system, and condenser. Emissivity measurements of relevant surfaces such as the chamber wall and the freeze dryer door were taken to evaluate the impact of atypical radiation heat transfer during scale-up. "Hot" and "cold" spots were identified on the shelf surface of different freeze dryers, and the impact of variation in shelf surface temperatures on the primary drying time and the product temperature during primary drying was studied. Calculations performed using emissivity measurements on different freeze dryers suggest that a front vial in the laboratory lyophilizer received 1.8 times more heat than a front vial in a manufacturing freeze dryer operating at a shelf temperature of -25 degrees C and a chamber pressure of 150 mTorr during primary drying. Therefore, front vials in the laboratory are much more atypical than front vials in manufacturing. Steady-state heat and mass transfer equations were used to study a combination of different scale-up issues pertinent during lyophilization cycles commonly used for the freeze-drying of pharmaceuticals.

The Analysis of the General Performance and Mechanical Behavior of Unirradiated FeCrAl Alloys Before and After Welding

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gussev, Maxim N.; Field, Kevin G.; Yamamoto, Yukinori

2016-06-03

The present report summarizes and discusses the preliminary results for the in-depth characterization of the modern, nuclear-grade FeCrAl alloys currently under development. The alloys were designed for enhanced radiation tolerance and weldability, and the research is currently being pursued by the Department of Energy (DOE) Nuclear Energy Enabling Technologies (NEET) program. Last year, seven candidate FeCrAl alloys with well-controlled chemistry and microstructures were designed and produced; welding was performed under well-controlled conditions. The structure and general performance of unirradiated alloys were assessed using standardized and advanced microstructural characterization techniques and mechanical testing. The primary objective is to identify the bestmore » candidate alloy, or at a minimum to identify the contributing factors that increase the weldability and radiation tolerance of FeCrAl alloys, therefore enabling future generations of FeCrAl alloys to deliver better performance parameters. This report is structured so as to describe these critical assessments of the weldability; radiation tolerance will be reported on in later reports from this program.« less

Determining the Parameters of Fractional Exponential Hereditary Kernels for Nonlinear Viscoelastic Materials

NASA Astrophysics Data System (ADS)

Golub, V. P.; Pavlyuk, Ya. V.; Fernati, P. V.

2013-03-01

The parameters of fractional-exponential hereditary kernels for nonlinear viscoelastic materials are determined. Methods for determining the parameters used in the third-order theory of viscoelasticity and in nonlinear theories based on the similarity of primary creep curves and the similarity of isochronous creep curves are analyzed. The parameters of fractional-exponential hereditary kernels are determined and tested against experimental data for microplastic, TC-8/3-250 glass-reinforced plastics, SVAM glass-reinforced plastics. The results (tables and plots) are analyzed

Detection of questionable occlusal carious lesions using an electrical bioimpedance method with fractional electrical model

NASA Astrophysics Data System (ADS)

Morais, A. P.; Pino, A. V.; Souza, M. N.

2016-08-01

This in vitro study evaluated the diagnostic performance of an alternative electric bioimpedance spectroscopy technique (BIS-STEP) detect questionable occlusal carious lesions. Six specialists carried out the visual (V), radiography (R), and combined (VR) exams of 57 sound or non-cavitated occlusal carious lesion teeth classifying the occlusal surfaces in sound surface (H), enamel caries (EC), and dentinal caries (DC). Measurements were based on the current response to a step voltage excitation (BIS-STEP). A fractional electrical model was used to predict the current response in the time domain and to estimate the model parameters: Rs and Rp (resistive parameters), and C and α (fractional parameters). Histological analysis showed caries prevalence of 33.3% being 15.8% hidden caries. Combined examination obtained the best traditional diagnostic results with specificity = 59.0%, sensitivity = 70.9%, and accuracy = 60.8%. There were statistically significant differences in bioimpedance parameters between the H and EC groups (p = 0.016) and between the H and DC groups (Rs, p = 0.006; Rp, p = 0.022, and α, p = 0.041). Using a suitable threshold for the Rs, we obtained specificity = 60.7%, sensitivity = 77.9%, accuracy = 73.2%, and 100% of detection for deep lesions. It can be concluded that BIS-STEP method could be an important tool to improve the detection and management of occlusal non-cavitated primary caries and pigmented sites.

Experimental validation of the tuneable diaphragm effect in modern acoustic stethoscopes.

PubMed

Nowak, Karolina M; Nowak, Lukasz J

2017-09-01

The force with which the diaphragm chestpiece of a stethoscope is pressed against the body of a patient during an auscultation examination introduces the initial stress and deformation to the diaphragm and the underlying tissues, thus altering the acoustic parameters of the sound transmission path. If the examination is performed by an experienced physician, he will intuitively adjust the amount of the force in order to achieve the optimal sound quality. However, in case of becoming increasingly popular auto-diagnosis and telemedicine auscultation devices with no such feedback mechanisms, the question arises regarding the influence of the possible force mismatch on the parameters of the recorded signal. The present study describes the results of the experimental investigations on the relation between pressure applied to the chestpiece of a stethoscope and parameters of the transmitted bioacoustic signals. The experiments were carried out using various stethoscopes connected to a force measurement system, which allowed to maintain fixed pressure during auscultation examinations. The signals were recorded during examinations of different volunteers, at various auscultation sites. The obtained results reveal strong individual and auscultation-site variability. It is concluded that the underlying tissue deformation is the primary factor that alters the parameters of the recorded signals. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Investigation of the electrical discharge parameters in electrodeless inductive lamps with a re-entrant coupler and magnetic core

NASA Astrophysics Data System (ADS)

Statnic, Eugen; Tanach, Valentin

2006-08-01

The inductively coupled fluorescent lamp with a cored induction coil placed in a re-entrant cavity is in fact a coaxial transformer operated in the radiofrequency range between 100 kHz and a few MHz. The magnetic coupling coefficient k between the primary coil and the plasma ring is relatively low because of the open magnetic circuit. The acting mutual inductance M enables us to quantify the interaction between the magnetic field produced by the primary coil current I1 and the opposing magnetic field produced by the powerful plasma current I2. A contra-electromotive force jωMI2 is induced in the induction coil L1, defining the primary voltage V1 = I1(R1 + jω L1) - jωMI2. The current I1 induces in the secondary conductive plasma the driving electromotive force jωMI1 supplying the secondary load consisting of the average plasma resistance R2 and the secondary inductance L2, according to the equation jωMI2 = I2(R2 + jωL2). It is the aim of this paper to find a model to determine k on the basis of the measured primary parameters V1, I1, P1, L1, R1 and finally all electrical inaccessible parameters, such as M, V2, I2, phiv2, L2, R2, in order to optimize the discharge and lamp efficacy. The complex characteristic of plasma inductance for this type of lamp is analysed and clarified. Some reflexive basic relations verifying the correctness of the inferred plasma parameters are also developed. The described experiments are related to a lamp working at about 2.6 MHz.

A Prospective Study in Comparison of Ambulatory Phlebectomy and Duplex Guided Foam Sclerotherapy in the Management of Varicosities with Isolated Perforator Incompetence.

PubMed

Kishore, R; Sankar, T Bavani; Anandi, A; Nedunchezhian, S; Murugan, Valarmathy

2016-10-01

Perforators are those which connect the superficial and deep venous system either directly to main veins or indirectly through the muscular and soleal venous plexus. The emergence of minimally invasive techniques like ambulatory phlebectomy (AP) and foam sclerotherapy (FS) has led to increasing interest about the appropriate therapy for the treatment of isolated perforator incompetence. There have been no studies which have compared the effectiveness of these in-office procedures in isolated perforator incompetence due to the low prevalence of cases. The primary goal of this study is to compare the clinical parameters (return to normal activity, primary symptom relief), functional parameters (procedure time, change in disease severity, course of venous ulcer), and duplex parameters (recurrence in treated veins, complete occlusion of treated veins) in the management of leg varicosities having isolated primary perforator incompetence by ambulatory phlebectomy and duplex guided foam sclerotherapy. Though the procedure time was shorter with FS than AP, the other parameters of primary symptom relief such as change in disease severity, faster healing of venous ulcer, complete occlusion of treated veins in follow-up duplex examination, and lower recurrence of treated veins are better with AP than FS. In conclusion, the interruption of perforators is effective in decreasing the symptoms of chronic venous insufficiency and for the rapid healing of ulcers. The interruption of the incompetent perforating veins appears to be essential to decrease ambulatory venous hypertension. It is apparent from this study that ambulatory phlebectomy stands distinct with enormous benefits and serves as a superior alternative to foam sclerotherapy in treating patients with isolated perforator incompetence.

Effect of primary and secondary parameters on analytical estimation of effective thermal conductivity of two phase materials using unit cell approach

NASA Astrophysics Data System (ADS)

S, Chidambara Raja; P, Karthikeyan; Kumaraswamidhas, L. A.; M, Ramu

2018-05-01

Most of the thermal design systems involve two phase materials and analysis of such systems requires detailed understanding of the thermal characteristics of the two phase material. This article aimed to develop geometry dependent unit cell approach model by considering the effects of all primary parameters (conductivity ratio and concentration) and secondary parameters (geometry, contact resistance, natural convection, Knudsen and radiation) for the estimation of effective thermal conductivity of two-phase materials. The analytical equations have been formulated based on isotherm approach for 2-D and 3-D spatially periodic medium. The developed models are validated with standard models and suited for all kind of operating conditions. The results have shown substantial improvement compared to the existing models and are in good agreement with the experimental data.

Potable water quality monitoring of primary schools in Magura district, Bangladesh: children's health risk assessment.

PubMed

Rahman, Aminur; Hashem, Abul; Nur-A-Tomal, Shahruk

2016-12-01

Safe potable water is essential for good health. Worldwide, school-aged children especially in the developing countries are suffering from various water-borne diseases. In the study, drinking water supplies for primary school children were monitored at Magura district, Bangladesh, to ensure safe potable water. APHA standard analytical methods were applied for determining the physicochemical parameters of the water samples. For determination of the essential physicochemical parameters, the samples were collected from 20 randomly selected tube wells of primary schools at Magura. The metal contents, especially arsenic (As), iron (Fe), and manganese (Mn), in the water samples were analyzed by atomic absorption spectroscopy. The range of physicochemical parameters found in water samples were as follows: pH 7.05-9.03, electrical conductivity 400-2340 μS/cm, chloride 10-640 mg/L, hardness 200-535 mg/L as CaCO 3 , and total dissolved solids 208-1216 mg/L. The level of metals in the tube well water samples were as follows: As 1 to 55 μg/L, Fe 40 to 9890 μg/L, and Mn 10 to 370 μg/L. Drinking water parameters of Magura district did not meet the requirement of the World Health Organization drinking water quality guideline, or the Drinking Water Quality Standards of Bangladesh.

ETF system code: composition and applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reid, R.L.; Wu, K.F.

1980-01-01

A computer code has been developed for application to ETF tokamak system and conceptual design studies. The code determines cost, performance, configuration, and technology requirements as a function of tokamak parameters. The ETF code is structured in a modular fashion in order to allow independent modeling of each major tokamak component. The primary benefit of modularization is that it allows updating of a component module, such as the TF coil module, without disturbing the remainder of the system code as long as the input/output to the modules remains unchanged. The modules may be run independently to perform specific design studies,more » such as determining the effect of allowable strain on TF coil structural requirements, or the modules may be executed together as a system to determine global effects, such as defining the impact of aspect ratio on the entire tokamak system.« less

Hydroxypropyl cellulose supplementation in vitrification solutions: a prospective study with donor oocytes.

PubMed

Gallardo, Miguel; Hebles, María; Migueles, Beatriz; Dorado, Mónica; Aguilera, Laura; González, Mercedes; Piqueras, Paloma; Lucas, Alejandro; Montero, Lorena; Sánchez-Martín, Pascual; Sánchez-Martín, Fernando; Risco, Ramón

2017-03-01

Hydroxypropyl cellulose (HPC), a polysaccharide that forms a viscous gel under low temperatures, is a promising substitute of the blood-derived macromolecules traditionally used in cryopreservation solutions. The performance of a protein-free, fully synthetic set of vitrification and warming solutions was assessed in a matched pair analysis with donor oocytes. A prospective study including 219 donor MII oocytes was carried out, comparing the laboratory outcomes of oocytes vitrified with HPC-based solutions and their fresh counterparts. The primary performance endpoint was the fertilization rate. Secondary parameters assessed were embryo quality on days 2 and 3. 70/73 (95.9%) vitrified MII oocytes exhibited morphologic survival 2 h post-warming, with 49 (70.0%) presented normal fertilization, compared to 105 of 146 (71.9%) MII fresh oocytes. Similar embryo quality was observed in both groups. A total of 18 embryos implanted, out of 38 embryos transferred (47.3%), resulting in 13 newborns.

Stiffness after total knee arthroplasty: does component alignment differ in knees requiring manipulation? A retrospective cohort study of 281 patients.

PubMed

Harvie, Paul; Larkin, James; Scaddan, Matt; Longstaff, Lee M; Sloan, Karen; Beaver, Richard J

2013-01-01

This study aims to evaluate component alignment in a large cohort of total knee arthroplasties (TKAs) and ascertain whether alignment in TKAs undergoing postoperative manipulation under anesthetic is significantly different from those achieving good function. A retrospective review of 281 consecutive primary TKAs was performed. All TKAs underwent computed tomographic scanning (Perth computed tomography knee protocol). Of 281 TKAs, 21 (7.4%) underwent manipulation, performed at a mean of 8.1 weeks (range, 3-14 weeks) after surgery. No statistically significant difference was seen between groups for any of 12 parameters of alignment. Postoperative stiffness with the need for manipulation under anesthetic is multifactorial in origin. This study found insufficient evidence to support the theory that component alignment contributes significantly to the etiology of this difficult problem. Crown Copyright © 2013. Published by Elsevier Inc. All rights reserved.

Friction Stir Welding of ODS and RAFM Steels

DOE PAGES

Yu, Zhenzhen; Feng, Zhili; Hoelzer, David; ...

2015-09-14

Advanced structural materials such as oxide dispersion strengthened steels and reduced-activation ferritic/martensitic steels are desired in fusion reactors as primary candidate materials for first wall and blanket structures, due to their excellent radiation and high-temperature creep resistance. However, their poor fusion weldability has been the major technical challenge limiting practical applications. For this reason, solid-state friction stir welding (FSW) has been considered for such applications. In this paper, the effect of FSW parameters on joining similar and dissimilar advanced structural steels was investigated. Scanning electron microscopy and electron backscatter diffraction methods were used to reveal the effects of FSW onmore » grain size, micro-texture distribution, and phase stability. Hardness mapping was performed to evaluate mechanical properties. Finally, post weld heat treatment was also performed to tailor the microstructure in the welds in order to match the weld zone mechanical properties to the base material.« less

High Performance Perovskite Solar Cells

PubMed Central

Tong, Xin; Lin, Feng; Wu, Jiang

2015-01-01

Perovskite solar cells fabricated from organometal halide light harvesters have captured significant attention due to their tremendously low device costs as well as unprecedented rapid progress on power conversion efficiency (PCE). A certified PCE of 20.1% was achieved in late 2014 following the first study of long‐term stable all‐solid‐state perovskite solar cell with a PCE of 9.7% in 2012, showing their promising potential towards future cost‐effective and high performance solar cells. Here, notable achievements of primary device configuration involving perovskite layer, hole‐transporting materials (HTMs) and electron‐transporting materials (ETMs) are reviewed. Numerous strategies for enhancing photovoltaic parameters of perovskite solar cells, including morphology and crystallization control of perovskite layer, HTMs design and ETMs modifications are discussed in detail. In addition, perovskite solar cells outside of HTMs and ETMs are mentioned as well, providing guidelines for further simplification of device processing and hence cost reduction. PMID:27774402

End region and current consolidation effects upon the performance of an MHD channel for the ETF conceptual design. [Engineering Test Facility

NASA Technical Reports Server (NTRS)

Wang, S. Y.; Smith, J. M.

1982-01-01

It is noted that operating conditions which yielded a peak thermodynamic efficiency (41%) for an EFT-size MHD/steam power plant were previously (Wang et al., 1981; Staiger, 1981) identified by considering only the active region (the primary portion for power production) of an MHD channel. These previous efforts are extended here to include an investigation of the effects of the channel end regions on overall power generation. Considering these effects, the peak plant thermodynamic efficiency is found to be slightly lowered (40.7%); the channel operating point for peak efficiency is shifted to the supersonic mode (Mach number of approximately 1.1) rather than the previous subsonic operation (Mach number of approximately 0.9). Also discussed is the sensitivity of the channel performance to the B-field, diffuser recovery coefficient, channel load parameter, Mach number, and combustor pressure.