Orion - Super Koropon(Registered Trademark) Torque/Tension Report

NASA Technical Reports Server (NTRS)

Hemminger, Edgar G.; McLeod, Christopher; Peil, John

2012-01-01

The primary objective of this testing was to obtain torque tension data for the use of Super Koropon Primer Base which was proposed for use on the Orion project. This compound is a corrosion inhibitor/sealer used on threaded fasteners and inserts as specified per NASA/JSC PRC-4004, Sealing of Joints and Faying Surfaces. Some secondary objectives of this testing, were to identify the effect on torque coefficient of several variables. This document contains the outcome of the testing.

Career Development in Primary School Children

ERIC Educational Resources Information Center

Nazli, Serap

2007-01-01

Purpose: This paper has three objectives. The first is to determine the level of primary school students' career development, the second is to test Super's childhood years career development model, and the third is to determine the level of Turkish children's career development. Design/methodology/approach: Employing qualitative research models,…

Perform MetalMapper Classification Treatability Investigations as Part of Remedial Investigation/Feasibility Studies: Live Site Demonstrations: Pueblo Chemical Depot

DTIC Science & Technology

2016-03-14

DoD Department of Defense EMI electromagnetic induction ESTCP Environmental Security Technology Certification Program ft. foot GPS global...three primary objectives:  Test and validate detection and discrimination capabilities of a currently available advanced electromagnetic induction ... induction (EMI) sensors in dynamic and static data acquisition modes and associated analysis software. To achieve these objectives, a controlled test was

EMISSION TEST REPORT, OMSS FIELD TEST ON CARBON INJECTION FOR MERCURY CONTROL

EPA Science Inventory

The report discusses results of a parametric evaluation of powdered activated carbon for control of mercury (Hg) emission from a municipal waste cornbustor (MWC) equipped with a lime spray dryer absorber/fabric filter (SD/FF). The primary test objectives were to evaluate the effe...

Evaluation of the Anaheim Advanced Traffic Control System Field Operational Test : introduction and Task A : evaluation of SCOOT performance

DOT National Transportation Integrated Search

1999-03-01

This report provides an overview of both the Anaheim Advanced Traffic Control System Field Operations Test (FOT) and of the technical issues associated with the evaluation of SCOOT performance during the test. The primary objective of the FOT was to ...

Verification and implementation of set-up empirical models in pile design : research project capsule.

DOT National Transportation Integrated Search

2016-08-01

The primary objectives of this research include: performing static and dynamic load tests on : newly instrumented test piles to better understand the set-up mechanism for individual soil : layers, verifying or recalibrating previously developed empir...

Evaluation of the Anaheim Advanced Traffic Control System Field Operational Test : executive summary

DOT National Transportation Integrated Search

1999-07-01

This Executive Summary provides an overview of the technical and institutional issues associated with the evaluation of the federally-sponsored Anaheim Advanced Traffic Control : System Field Operations Test. The primary FOT objective was the impleme...

Supporting the Integration of HIV Testing Into Primary Care Settings

PubMed Central

Bradley-Springer, Lucy; Kang Dufour, Mi-Suk; Koester, Kimberly A.; Beane, Stephanie; Warren, Nancy; Beal, Jeffrey; Frank, Linda Rose

2012-01-01

Objectives. We examined the efforts of the US network of AIDS Education and Training Centers (AETCs) to increase HIV testing capacity across a variety of clinical settings. Methods. We used quantitative process data from 8 regional AETCs for July 1, 2008, to June 30, 2009, and qualitative program descriptions to demonstrate how AETC education helped providers integrate HIV testing into routine clinical care with the goals of early diagnosis and treatment. Results. Compared with other AETC training, HIV testing training was longer and used a broader variety of strategies to educate more providers per training. During education, providers were able to understand their primary care responsibility to address public health concerns through HIV testing. Conclusions. AETC efforts illustrate how integration of the principles of primary care and public health can be promoted through professional training. PMID:22515867

Assessment of the potential of Allium sativum oil as a new medicament for non-vital pulpotomy of primary teeth

PubMed Central

Mohammad, Shukry Gamal; Baroudi, Kusai

2015-01-01

Objective: The objective of this study was to compare the clinical and radiographic effects of Allium sativum oil and formocresol in nonvital pulpotomy in primary teeth. Materials and Methods: Twenty children ranging in age from 4 to 8 years were included in the study. In every one of those children, pulpotomy was indicated for the primary molars. Pulpotomy procedure was performed and the radicular pulp tissue of one molar was capped with A. sativum oil in a cotton pellet while the other molar was capped with formocresol. The teeth were evaluated clinically and radiographically before and after 6 months using standard clinical and radiographic criteria. Statistically, these results revealed significant difference between the radiographic findings of nonvital pulpotomy in primary molars with the two medicaments. Statistical analysis was performed using independent t-test and paired t-test at the significance level of α = 0.05. Results: A. sativum oil has potent antibacterial properties that enable it to combat intracanal microbes in the infected pulp of primary molars. Better results were obtained when A. sativum oil was used. Conclusion: A. sativum oil had more powerful effects than formocresol on the infected pulp of primary nonvital molars. PMID:26312232

The Systems Analysis Approach to Satellite Education in Brazil.

ERIC Educational Resources Information Center

Cusack, Mary Ann

The SACI project in Brazil has as a main target the country's primary teachers. The SACI Project objectives are: (1) to test the efficiency of an educational program using audiovisual media (particularly television, radio, and slow scan) at the primary level; (2) to develop television production techniques; (3) to train teachers in the utilization…

APT-ALF testing at LTRC in Louisiana : summary report.

DOT National Transportation Integrated Search

2012-09-01

As an integral part of Study 0-6132, the primary objectives of this task included the following: : 1) To validate the new generation mix-design procedure (balanced) under APT testing using the ALF machine. : 2) To compare the HMA mix performance desi...

Development of models to estimate the subgrade and subbase layers' resilient modulus from in-situ devices test results for construction control.

DOT National Transportation Integrated Search

2009-05-01

The primary objective of this research was to develop models that predict the resilient modulus of cohesive and granular soils from the test results of various in-situ test devices for possible application in QA/QC during construction of pavement str...

Proof testing a bridge deck design with glass fiber reinforced polymer bars as top mat of reinforcement.

DOT National Transportation Integrated Search

2003-01-01

The primary objective of this project was to test a full-scale prototype of a bridge deck design containing glass fiber reinforced polymer (GFRP) bars as the top mat of reinforcement. The test deck mimics the design of the deck of one span of the new...

Evaluation of the Anaheim Advanced Traffic Control System Field Operational Test : Task B : assessment of institutional issues

DOT National Transportation Integrated Search

1999-07-01

This report provides an overview of the technical and institutional issues associated with the : evaluation of the federally-sponsored Anaheim Advanced Traffic Control System Field Operations Test. The primary FOT objective was the implementation and...

TP89 - SIRZ Decomposition Spectral Estimation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Seetho, Isacc M.; Azevedo, Steve; Smith, Jerel

2016-12-08

The primary objective of this test plan is to provide X-ray CT measurements of known materials for the purposes of generating and testing MicroCT and EDS spectral estimates. These estimates are to be used in subsequent Ze/RhoE decomposition analyses of acquired data.

Design development of graphite primary structures enables SSTO success

NASA Astrophysics Data System (ADS)

Biagiotti, V. A.; Yahiro, J. S.; Suh, Daniel E.; Hodges, Eric R.; Prior, Donald J.

1997-01-01

This paper describes the development of a graphite composite wing and a graphite composite intertank primary structure for application toward Single-Stage to Orbit space vehicles such as those under development in NASA's X-33/Reusable Launch Vehicle (RLV) Program. The trade study and designs are based on a Rockwell vertical take-off and horizontal landing (VTHL) wing-body RLV vehicle. Northrop Grumman's approach using a building block development technique is described. Composite Graphite/Bismaleimide (Gr/BMI) material characterization test results are presented. Unique intertank and wing composite subcomponent test article designs are described and test results to date are presented. Wing and intertank Full Scale Section Test Article (FSTA) objectives and designs are outlined. Trade studies, supporting building block testing, and FSTA demonstrations combine to develop graphite primary structure composite technology that enables developing X-33/RLV design programs to meet critical SSTO structural weight and operations performance criteria.

Computer simulation of thermal modeling of primary lithium cells

NASA Technical Reports Server (NTRS)

Young, I. Cho; Frank, Harvey; Halpert, Gersid

1987-01-01

The objective was to gain a better understanding of the safety problem of primary Li-SOCl2 and Li-SO2 cells by carrying out detailed thermal modeling work. In particular, the transient heat generation rates during moderate and extermely high discharge rate tests of Li-SOCl2 cells were predicted and compared with those from the electrochemical heating. The difference between the two may be attributed to the lithium corrosion and other chemical reactions. The present program was also tested for charging of Li-SO2. In addition, the present methodology should be applicable to other primary cylindrical cells as well as rechargeable battery analyses with minor modifications.

Phase I Final Scientific Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lu, Xijia; Fetvedt, Jeremy; Dimmig, Walker

This Final Scientific Report addresses the accomplishments achieved during Phase I of DE- FE0023985, Coal Syngas Combustor Development for Supercritical CO 2 Power Cycles. The primary objective of the project was to develop a coal syngas-fueled combustor design for use with high-pressure, high-temperature, oxy-fuel, supercritical CO 2 power cycles, with particular focus given to the conditions required by the Allam Cycle. The primary goals, from the Statement of Project Objectives, were to develop: (1) a conceptual design of a syngas-fueled combustor-turbine block for a 300MWe high-pressure, oxy-fuel, sCO2 power plant; (2) the preliminary design of a 5MWt test combustor; andmore » (3) the definition of a combustor test program. Accomplishments for each of these goals are discussed in this report.« less

SUPERFUND TREATABILITY CLEARINGHOUSE: INCINERATION TEST OF EXPLOSIVES CONTAMINATED SOILS AT SAVANNA ARMY DEPOT ACTIVITY, SAVANNA, ILLINOIS

EPA Science Inventory

The primary objective of these tests was to demonstrate the effectiveness of incineration as a decontamination method for explosives contaminated sails. A pilot-scale rotary kiln incinerator, manufactured by ThermAll, Inc., was used to treat both sandy and clayey...

FACTORS AFFECTING REPRODUCTION AND THE IMPORTANCE OF ADULT SIZE ON REPRODUCTIVE OUTPUT OF THE MIDGE, CHIRONOMUS TENTANS

EPA Science Inventory

Incorporating reproductive endpoints into sediment toxicity tests has become an important consideration in ecological risk assessments. The capacity to assess reproduction was one of the primary objectives underlying the recent development of a life-cycle test with the midge, Ch...

THE VERTICAL PLANAR MOTION MECHANISM; A DYNAMIC TEST APPARATUS FOR EVALUATING CURRENT METERS AND OTHER MARINE INSTRUMENTATION

EPA Science Inventory

The overall objective was to provide a dynamic test apparatus that can produce known, controlled high frequency dynamics for the evaluation of current meters and other marine instrumentation. Of primary interest is the establishment of flow sensor measurement capabilities, and he...

[Design of a supervision model for administration of the Child Development Evaluation Test at primary care facilities in Mexico].

PubMed

Villasís-Keever, Miguel Ángel; Rizzoli-Córdoba, Antonio; Delgado-Ginebra, Ismael; Mares-Serratos, Blanca Berenice; Martell-Valdez, Liliana; Sánchez-Velázquez, Olivia; Reyes-Morales, Hortensia; O'Shea-Cuevas, Gabriel; Aceves-Villagrán, Daniel; Carrasco-Mendoza, Joaquín; Antillón-Ocampo, Fátima Adriana; Villagrán-Muñoz, Víctor Manuel; Halley-Castillo, Elizabeth; Baqueiro-Hernández, César Iván; Pizarro-Castellanos, Mariel; Martain-Pérez, Itzamara Jacqueline; Palma-Tavera, Josuha Alexander; Vargas-López, Guillermo; Muñoz-Hernández, Onofre

The Child Development Evaluation (CDE) test designed and validated in Mexico has been used as a screening tool for developmental problems in primary care facilities across Mexico. Heterogeneous results were found among those states where these were applied, despite using the same standardized training model for application. The objective was to evaluate a supervision model for quality of application of the CDE test at primary care facilities. A study was carried out in primary care facilities from three Mexican states to evaluate concordance of the results between supervisor and primary care personnel who administered the test using two different methods: direct observation (shadow study) or reapplication of the CDE test (consistency study). There were 380 shadow studies applied to 51 psychologists. General concordance of the shadow study was 86.1% according to the supervisor: green 94.5%, yellow 73.2% and red 80.0%. There were 302 re-test evaluations with a concordance of 88.1% (n=266): green 96.8%, yellow 71.7% and red 81.8%. There were no differences between CDE test subgroups by age. Both shadow and re-test study were adequate for the evaluation of the quality of the administration of the CDE Test and may be useful as a model of supervision in primary care facilities. The decision of which test to use relies on the availability of supervisors. Copyright © 2015 Hospital Infantil de México Federico Gómez. Publicado por Masson Doyma México S.A. All rights reserved.

Pretest analysis document for Test S-FS-7

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hall, D.G.

This report documents the pretest calculations completed for Semiscale Test S-FS-7. This test will simulate a transient initiated by a 14.3% break in a steam generator bottom feedwater line downstream of the check valve. The initial conditions represent normal operating conditions for a C-E System 80 nuclear power plant. Predictions of transients resulting from feedwater line breaks in these plants have indicated that significant primary system overpressurization may occur. The results of a RELAP5/MOD2/CY21 code calculation indicate that the test objectives for Test S-FS-7 can be achieved. The primary system overpressurization will occur but pose no threat to personnel ormore » to plant integrity. 3 refs., 15 figs., 5 tabs.« less

Pretest analysis document for Test S-FS-11

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hall, D.G.; Shaw, R.A.

This report documents the pretest calculations completed for Semiscale Test S-FS-11. This test will simulate a transient initiated by a 50% break in a steam generator bottom feedwater line downstream of the check valve. The initial conditions represents normal operating conditions for a C-E System 80 nuclear plant. Prediction of transients resulting from feedwater line breaks in these plants have indicated that significant primary system overpressurization may occur. The results of a RELAP5/MOD2/CY21 code calculation indicate that the test objectives for Test S-FS-11 can be achieved. The primary system overpressurization will occur but pose no threat to personnel or plantmore » integrity. 3 refs., 15 figs., 5 tabs.« less

Current and future use of point-of-care tests in primary care: an international survey in Australia, Belgium, The Netherlands, the UK and the USA

PubMed Central

Howick, Jeremy; Cals, Jochen W L; Jones, Caroline; Price, Christopher P; Plüddemann, Annette; Heneghan, Carl; Berger, Marjolein Y; Buntinx, Frank; Hickner, John; Pace, Wilson; Badrick, Tony; Van den Bruel, Ann; Laurence, Caroline; van Weert, Henk C; van Severen, Evie; Parrella, Adriana; Thompson, Matthew

2014-01-01

Objective Despite the growing number of point-of-care (POC) tests available, little research has assessed primary care clinician need for such tests. We therefore aimed to determine which POC tests they actually use or would like to use (if not currently available in their practice). Design Cross-sectional survey. Setting Primary care in Australia, Belgium (Flanders region only), the Netherlands, the UK and the USA. Participants Primary care doctors (general practitioners, family physicians). Main measures We asked respondents to (1) identify conditions for which a POC test could help inform diagnosis, (2) from a list of tests provided: evaluate which POC tests they currently use (and how frequently) and (3) determine which tests (from that same list) they would like to use in the future (and how frequently). Results 2770 primary care clinicians across five countries responded. Respondents in all countries wanted POC tests to help them diagnose acute conditions (infections, acute cardiac disease, pulmonary embolism/deep vein thrombosis), and some chronic conditions (diabetes, anaemia). Based on the list of POC tests provided, the most common tests currently used were: urine pregnancy, urine leucocytes or nitrite and blood glucose. The most commonly reported tests respondents expressed a wish to use in the future were: D-dimer, troponin and chlamydia. The UK and the USA reported a higher actual and desired use for POC tests than Australia, Belgium and the Netherlands. Our limited data suggest (but do not confirm) representativeness. Conclusions Primary care clinicians in all five countries expressed a desire for POC tests to help them diagnose a range of acute and chronic conditions. Rates of current reported use and desired future use were generally high for a small selection of POC tests, but varied across countries. Future research is warranted to explore how specific POC tests might improve primary care. PMID:25107438

Tabla de Especificaciones e Instructivo sobre Elaboracion de Pruebas Objetivas en la Ensenanza Primaria, para las asignaturas de Estudios Sociales, Idioma Espanol, Matematicas y Ciencias Naturales (Specification Tables and Instructions for the Construction of Objective Tests in the Primary Grades in Social Studies, Spanish, Mathematics, and Natural Sciences).

ERIC Educational Resources Information Center

Ministerio de Educacion, Guatemala City (Guatemala). Direccion de Bienestar Estudiantil y Educacion Especial.

This booklet presents specification tables illustrating the relative importance given to topics on tests within a particular subject area. The general subject areas are social studies, Spanish, mathematics, and natural sciences. Tables are provided for final exams in each of these areas for several primary grades, illustrating the importance of…

Performance evaluation of Louisiana superpave mixtures : tech summary.

DOT National Transportation Integrated Search

2008-12-01

The primary objective of this research was to evaluate the fundamental engineering : properties and mixture performance of Superpave hot mix asphalt (HMA) mixtures : in Louisiana through laboratory mechanistic tests, aggregate gradation analysis, and...

Examination of Skill Acquisition and Grader Bias in a Distal Radius Fracture Fixation Model.

PubMed

Putnam, Matthew D; Adams, Julie E; Lender, Paul; Van Heest, Ann E; Shanedling, Janet R; Nuckley, David J; Bechtold, Joan E

2018-03-01

Primary: Assess the ability of faculty graders to predict the objectively measured strength of distal radius fracture fixation. Secondary: Compare resident skill variation and retention related to other knowable training data. Residents were allowed 60 minutes to stabilize a standardized distal radius fracture using an assigned fixed-angle volar plate. Faculty observed and subjectively graded the residents without providing real-time feedback. Objective biomechanical evaluation (construct strength and stiffness) was compared to subjective grades. Resident-specific characteristics (sex, PGY, and ACGME case log) were also used to compare the objective data. A simulated operating room in our laboratory. Post-graduate year 2, 3, 4, and 5 orthopedic residents. Primary: Faculty were not successful at predicting objectively measured fixation, and their subjective scoring suggests confirmation bias as PGY increased. Secondary: Resident year-in-training alone did not predict objective measures (p = 0.53), but was predictive of subjective scores (p < 0.001). Skills learned were not always retained, as 29% of residents objectively failed subsequent to passing. Notably, resident-reported case-specific experience alone was inversely correlated with objective fixation strength. This testing model enabled the collection of objective and subjective resident skill scores. Faculty graders did not routinely predict objective measures, and their subjective assessment appears biased related to PGY. Also, in vivo case volume alone does not predict objective results. Familiar faculty teaching consistency, and resident grading by external faculty unfamiliar with tested residents, might alter these results. Copyright © 2018 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

Evaluating Topic Model Interpretability from a Primary Care Physician Perspective

PubMed Central

Arnold, Corey W.; Oh, Andrea; Chen, Shawn; Speier, William

2015-01-01

Background and Objective Probabilistic topic models provide an unsupervised method for analyzing unstructured text. These models discover semantically coherent combinations of words (topics) that could be integrated in a clinical automatic summarization system for primary care physicians performing chart review. However, the human interpretability of topics discovered from clinical reports is unknown. Our objective is to assess the coherence of topics and their ability to represent the contents of clinical reports from a primary care physician’s point of view. Methods Three latent Dirichlet allocation models (50 topics, 100 topics, and 150 topics) were fit to a large collection of clinical reports. Topics were manually evaluated by primary care physicians and graduate students. Wilcoxon Signed-Rank Tests for Paired Samples were used to evaluate differences between different topic models, while differences in performance between students and primary care physicians (PCPs) were tested using Mann-Whitney U tests for each of the tasks. Results While the 150-topic model produced the best log likelihood, participants were most accurate at identifying words that did not belong in topics learned by the 100-topic model, suggesting that 100 topics provides better relative granularity of discovered semantic themes for the data set used in this study. Models were comparable in their ability to represent the contents of documents. Primary care physicians significantly outperformed students in both tasks. Conclusion This work establishes a baseline of interpretability for topic models trained with clinical reports, and provides insights on the appropriateness of using topic models for informatics applications. Our results indicate that PCPs find discovered topics more coherent and representative of clinical reports relative to students, warranting further research into their use for automatic summarization. PMID:26614020

Testing Activity Monitors’ Effect on Health: Study Protocol for a Randomized Controlled Trial Among Older Primary Care Patients

PubMed Central

Ottenbacher, Kenneth J; Fisher, Steve R; Jennings, Kristofer; Brown, Arleen F; Swartz, Maria C; Lyons, Elizabeth J

2016-01-01

Background Cardiovascular disease is the leading cause of mortality in the United States. Maintaining healthy levels of physical activity is critical to cardiovascular health, but many older adults are inactive. There is a growing body of evidence linking low motivation and inactivity. Standard behavioral counseling techniques used within the primary care setting strive to increase motivation, but often do not emphasize the key component of self-control. The addition of electronic activity monitors (EAMs) to counseling protocols may provide more effective behavior change and increase overall motivation for exercise through interactive self-monitoring, feedback, and social support from other users. Objective The objective of the study is to conduct a three month intervention trial that will test the feasibility of adding an EAM system to brief counseling within a primary care setting. Participants (n=40) will be randomized to receive evidence-based brief counseling plus either an EAM or a pedometer. Methods Throughout the intervention, we will test its feasibility and acceptability, the change in primary outcomes (cardiovascular risk and physical activity), and the change in secondary outcomes (adherence, weight and body composition, health status, motivation, physical function, psychological feelings, and self-regulation). Upon completion of the intervention, we will also conduct focus groups with the participants and with primary care stakeholders. Results The study started recruitment in October 2015 and is scheduled to be completed by October 2016. Conclusions This project will lay the groundwork and establish the infrastructure for intervention refinement and ultimately translation within the primary care setting in order to prevent cardiovascular disease on a population level. Trial Registration ClinicalTrails.gov NCT02554435; https://clinicaltrials.gov/ct2/show/NCT02554435 (Archived by WebCite at http://www.webcitation/6fUlW5tdT) PMID:27129602

Firebreak Maintenance With Soil Sterilants

Treesearch

James K. Brown

1966-01-01

In 1959 and 1962 the Minnesota Division of Forestry and the North Central Forest Experiment Station established a series of tests to determine the effectiveness of several herbicides in maintaining firebreaks free of vegetation. The primary objectives of these tests were to determine: (1) how long one application of soil sterilant can keep firebreaks satisfactorily...

Selective verbal recognition memory impairments are associated with atrophy of the language network in non-semantic variants of primary progressive aphasia.

PubMed

Nilakantan, Aneesha S; Voss, Joel L; Weintraub, Sandra; Mesulam, M-Marsel; Rogalski, Emily J

2017-06-01

Primary progressive aphasia (PPA) is clinically defined by an initial loss of language function and preservation of other cognitive abilities, including episodic memory. While PPA primarily affects the left-lateralized perisylvian language network, some clinical neuropsychological tests suggest concurrent initial memory loss. The goal of this study was to test recognition memory of objects and words in the visual and auditory modality to separate language-processing impairments from retentive memory in PPA. Individuals with non-semantic PPA had longer reaction times and higher false alarms for auditory word stimuli compared to visual object stimuli. Moreover, false alarms for auditory word recognition memory were related to cortical thickness within the left inferior frontal gyrus and left temporal pole, while false alarms for visual object recognition memory was related to cortical thickness within the right-temporal pole. This pattern of results suggests that specific vulnerability in processing verbal stimuli can hinder episodic memory in PPA, and provides evidence for differential contributions of the left and right temporal poles in word and object recognition memory. Copyright © 2017 Elsevier Ltd. All rights reserved.

Hanford spent nuclear fuel hot conditioning system test procedure

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cleveland, K.J.

1997-09-16

This document provides the test procedures for cold testing of the prototype Hot Conditioning System (HCS) at the 306E Facility. The primary objective of this testing is to confirm design choices and provide data for the detailed design package prior to procurement of the process equipment. The current scope of testing in this document includes a fabricability study of the HCS, equipment performance testing of the HCS components, heat-up and cool-down cycle simulation, and robotic arm testing.

Staff Perspectives on the Use of a Computer-Based Concept for Lifestyle Intervention Implemented in Primary Health Care

ERIC Educational Resources Information Center

Carlfjord, Siw; Johansson, Kjell; Bendtsen, Preben; Nilsen, Per; Andersson, Agneta

2010-01-01

Objective: The aim of this study was to evaluate staff experiences of the use of a computer-based concept for lifestyle testing and tailored advice implemented in routine primary health care (PHC). Design: The design of the study was a cross-sectional, retrospective survey. Setting: The study population consisted of staff at nine PHC units in the…

Continuous GPS : pilot applications - Phase II

DOT National Transportation Integrated Search

2003-08-01

The primary objective of this research was to evaluate the feasibility of applying Global Positioning System (GPS) technology in the study of geotechnical phenomenon by developing, integrating, and test deploying a GPS-based instrumentation package u...

Rating Your Cash Manager?

ERIC Educational Resources Information Center

Nielsen, George A.; Johannisson, Eric E.

1989-01-01

The primary objective of a public cash management policy should include safety, liquidity, yield, and legality. Contains a cash management policy/procedure checklist, a test for cash managers, and a formula for calculating the rate of return. (MLF)

Design development of graphite primary structures enables SSTO success

DOE Office of Scientific and Technical Information (OSTI.GOV)

Biagiotti, V.A.; Yahiro, J.S.; Suh, D.E.

1997-01-01

This paper describes the development of a graphite composite wing and a graphite composite intertank primary structure for application toward Single-Stage to Orbit space vehicles such as those under development in NASA{close_quote}s X-33/Reusable Launch Vehicle (RLV) Program. The trade study and designs are based on a Rockwell vertical take-off and horizontal landing (VTHL) wing-body RLV vehicle. Northrop Grumman{close_quote}s approach using a building block development technique is described. Composite Graphite/Bismaleimide (Gr/BMI) material characterization test results are presented. Unique intertank and wing composite subcomponent test article designs are described and test results to date are presented. Wing and intertank Full Scale Sectionmore » Test Article (FSTA) objectives and designs are outlined. Trade studies, supporting building block testing, and FSTA demonstrations combine to develop graphite primary structure composite technology that enables developing X-33/RLV design programs to meet critical SSTO structural weight and operations performance criteria. {copyright} {ital 1997 American Institute of Physics.}« less

Optimization-based scatter estimation using primary modulation for computed tomography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Yi; Ma, Jingchen; Zhao, Jun, E-mail: junzhao

Purpose: Scatter reduces the image quality in computed tomography (CT), but scatter correction remains a challenge. A previously proposed primary modulation method simultaneously obtains the primary and scatter in a single scan. However, separating the scatter and primary in primary modulation is challenging because it is an underdetermined problem. In this study, an optimization-based scatter estimation (OSE) algorithm is proposed to estimate and correct scatter. Methods: In the concept of primary modulation, the primary is modulated, but the scatter remains smooth by inserting a modulator between the x-ray source and the object. In the proposed algorithm, an objective function ismore » designed for separating the scatter and primary. Prior knowledge is incorporated in the optimization-based framework to improve the accuracy of the estimation: (1) the primary is always positive; (2) the primary is locally smooth and the scatter is smooth; (3) the location of penumbra can be determined; and (4) the scatter-contaminated data provide knowledge about which part is smooth. Results: The simulation study shows that the edge-preserving weighting in OSE improves the estimation accuracy near the object boundary. Simulation study also demonstrates that OSE outperforms the two existing primary modulation algorithms for most regions of interest in terms of the CT number accuracy and noise. The proposed method was tested on a clinical cone beam CT, demonstrating that OSE corrects the scatter even when the modulator is not accurately registered. Conclusions: The proposed OSE algorithm improves the robustness and accuracy in scatter estimation and correction. This method is promising for scatter correction of various kinds of x-ray imaging modalities, such as x-ray radiography, cone beam CT, and the fourth-generation CT.« less

A STUDY OF THE CONCURRENT VALIDITY OF THE MINNESOTA TESTS OF CREATIVE THINKING, ABBR. FORM VII, FOR EIGHTH GRADE INDUSTRIAL ARTS STUDENTS.

ERIC Educational Resources Information Center

DUENK, LESTER G.

THE PRIMARY OBJECTIVE OF THIS STUDY WAS TO ESTABLISH THE CONCURRENT VALIDITY OF THE MINNESOTA TESTS OF CREATIVE THINKING, ABBREVIATED FORM VII, (MTCT VII) BY DETERMINING THE RELATIONSHIP BETWEEN ITS SCORES AND CREATIVE ABILITY AS MEASURED BY ACCUMULATED TEACHER RATINGS OF INDUSTRIAL ARTS PROJECTS AND INVESTIGATOR-DEVELOPED TESTS OF CREATIVITY. THE…

Development and evaluation of an airplane electronic display format aligned with the inertial velocity vector

NASA Technical Reports Server (NTRS)

Steinmetz, G. G.

1986-01-01

The development of an electronic primary flight display format aligned with the aircraft velocity vector, a simulation evaluation comparing this format with an electronic attitude-aligned primary flight display format, and a flight evaluation of the velocity-vector-aligned display format are described. Earlier tests in turbulent conditions with the electronic attitude-aligned display format had exhibited unsteadiness. A primary objective of aligning the display format with the velocity vector was to take advantage of a velocity-vector control-wheel steering system to provide steadiness of display during turbulent conditions. Better situational awareness under crosswind conditions was also achieved. The evaluation task was a curved, descending approach with turbulent and crosswind conditions. Primary flight display formats contained computer-drawn perspective runway images and flight-path angle information. The flight tests were conducted aboard the NASA Transport Systems Research Vehicle (TSRV). Comparative results of the simulation and flight tests were principally obtained from subjective commentary. Overall, the pilots preferred the display format aligned with the velocity vector.

Effects of surface chemistry on hot corrosion life

NASA Technical Reports Server (NTRS)

Fryxell, R. E.; Leese, G. E.

1985-01-01

This program has its primary objective: the development of hot corrosion life prediction methodology based on a combination of laboratory test data and evaluation of field service turbine components which show evidence of hot corrosion. The laboratory program comprises burner rig testing by TRW. A summary of results is given for two series of burner rig tests. The life prediction methodology parameters to be appraised in a final campaign of burner rig tests are outlined.

RTG Safety Tests

NASA Technical Reports Server (NTRS)

1989-01-01

The primary objective of STS-34 was to launch Galileo on its trip to Jupiter. The Galileo spacecraft contains two Radioisotope Thermoelectric Generators (RTG), which contains plutonium. This videotape shows and the accompanying material explains the tests that the RTG containment vessel has been subjected to, and the results of the tests. The videotape shows the trajectory of the Galileo spacecraft, a cutaway view of an RTG, the Plutonium-238 fuel capsule, and seven of the tests on the RTG.

Health risk appraisal and safety belt use

DOT National Transportation Integrated Search

1987-05-01

The primary objective of this study was to determine the effectiveness of health risk appraisal (HRA) programs for increasing claimed and observed safety belt use. HRA programs were field tested with and without supplemental educational materials on ...

Effects of aggregate angularity on mix design characteristics and pavement performance.

DOT National Transportation Integrated Search

2009-12-01

This research targeted two primary purposes: to estimate current aggregate angularity test methods and to evaluate current : aggregate angularity requirements in the Nebraska asphalt mixture/pavement specification. To meet the first research : object...

Concrete crosstie fastener sub-system testing and modeling.

DOT National Transportation Integrated Search

2014-02-10

The primary objective of this project is to identify methods of improving concrete railroad crosstie fastening system design and performance by conducting a thorough investigation of the behavior of the fastening system using Finite Element Analysis ...

Evaluation of bond strength between pavement layers.

DOT National Transportation Integrated Search

2005-12-01

The primary objective of this project was to develop a test for measuring the bond strength : between pavement layers. The research was also to evaluate tack coat materials and application : rates for the Alabama Department of Transportation (ALDOT)....

Display and analysis of crash data

DOT National Transportation Integrated Search

2005-04-01

This report describes the development and testing of a new Geographic Information System (GIS) application for the display and analysis of crash data stored in the Critical Analysis Reporting Environment (CARE) system. The primary objective of this s...

Optimizing DER Participation in Inertial and Primary-Frequency Response

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dall-Anese, Emiliano; Zhao, Changhong; Guggilam, Swaroop

This paper develops an approach to enable the optimal participation of distributed energy resources (DERs) in inertial and primary-frequency response alongside conventional synchronous generators. Leveraging a reduced-order model description of frequency dynamics, DERs' synthetic inertias and droop coefficients are designed to meet time-domain performance objectives of frequency overshoot and steady-state regulation. Furthermore, an optimization-based method centered around classical economic dispatch is developed to ensure that DERs share the power injections for inertial- and primary-frequency response in proportion to their power ratings. Simulations for a modified New England test-case system composed of ten synchronous generators and six instances of the IEEEmore » 37-node test feeder with frequency-responsive DERs validate the design strategy.« less

Pretest analysis document for Test S-FS-6

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shaw, R.A.; Hall, D.G.

This report documents the pretest analyses completed for Semiscale Test S-FS-6. This test will simulate a transient initiated by a 100% break in a steam generator bottom feedwater line downstream of the check valve. The initial conditions represent normal operating conditions for a C-E System 80 nuclear power plant. Predictions of transients resulting from feedwater line breaks in these plants have indicated that significant primary system overpressurization may occur. The enclosed analyses include a RELAP5/MOD2/CY21 code calculation and preliminary results from a facility hot, integrated test which was conducted to near S-FS-6 specifications. The results of these analyses indicate thatmore » the test objectives for Test S-FS-6 can be achieved. The primary system overpressurization will pose no threat to personnel or plant integrity.« less

Relationships Between the 1960 Stanford-Binet Scale and Group Measures of Intelligence and Achievement

ERIC Educational Resources Information Center

Churchill, William D.; Smith, Stuart E.

1974-01-01

This study is concerned with the determination of relationships between the 1960 Revised Stanford-Binet Intelligence Scale, the Lorge-Thorndike Intelligence Test, and the Iowa Tests of Basic Skills. The primary objective of the investigation was to determine the predictive validity of the 1960 Stanford-Binet over a period of eight years. (Author)

The Treatment Advocacy Program: A Randomized Controlled Trial of a Peer-Led Safer Sex Intervention for HIV-Infected Men Who Have Sex with Men

ERIC Educational Resources Information Center

McKirnan, David J.; Tolou-Shams, Marina; Courtenay-Quirk, Cari

2010-01-01

Objective: Primary care may be an effective venue for delivering behavioral interventions for sexual safety among HIV-positive men who have sex with men (MSM); however, few studies show efficacy for such an approach. We tested the efficacy of the Treatment Advocacy Program (TAP), a 4-session, primary-care-based, individual counseling intervention…

Cognitive Assessment Interview (CAI): Validity as a co-primary measure of cognition across phases of schizophrenia.

PubMed

Ventura, Joseph; Subotnik, Kenneth L; Ered, Arielle; Hellemann, Gerhard S; Nuechterlein, Keith H

2016-04-01

Progress has been made in developing interview-based measures for the assessment of cognitive functioning, such as the Cognitive Assessment Interview (CAI), as co-primary measures that compliment objective neurocognitive assessments and daily functioning. However, a few questions remain, including whether the relationships with objective cognitive measures and daily functioning are high enough to justify the CAI as an co-primary measure and whether patient-only assessments are valid. Participants were first-episode schizophrenia patients (n=60) and demographically-similar healthy controls (n=35), chronic schizophrenia patients (n=38) and demographically similar healthy controls (n=19). Participants were assessed at baseline with an interview-based measure of cognitive functioning (CAI), a test of objective cognitive functioning, functional capacity, and role functioning at baseline, and in the first episode patients again 6 months later (n=28). CAI ratings were correlated with objective cognitive functioning, functional capacity, and functional outcomes in first-episode schizophrenia patients at similar magnitudes as in chronic patients. Comparisons of first-episode and chronic patients with healthy controls indicated that the CAI sensitively detected deficits in schizophrenia. The relationship of CAI Patient-Only ratings with objective cognitive functioning, functional capacity, and daily functioning were comparable to CAI Rater scores that included informant information. These results confirm in an independent sample the relationship of the CAI ratings with objectively measured cognition, functional capacity, and role functioning. Comparison of schizophrenia patients with healthy controls further validates the CAI as an co-primary measure of cognitive deficits. Also, CAI change scores were strongly related to objective cognitive change indicating sensitivity to change. Copyright © 2016 Elsevier B.V. All rights reserved.

PERSONAL CHARACTERISTICS OF OLDER PRIMARY CARE PATIENTS WHO PROVIDE A BUCCAL SWAB FOR APOE TESTING AND BANKING OF GENETIC MATERIAL: THE SPECTRUM STUDY

PubMed Central

Bogner, Hillary R.; Wittink, Marsha N.; Merz, Jon F.; Straton, Joseph B.; Cronholm, Peter F.; Rabins, Peter V.; Gallo, Joseph J.

2009-01-01

OBJECTIVE To determine the personal characteristics and reasons associated with providing a buccal swab for APOE genetic testing in a primary care study. METHODS The study sample consisted of 342 adults aged 65 years and older recruited from primary care settings. RESULTS In all, 88% of patients agreed to provide a DNA sample for APOE genotyping and 78% of persons providing a sample agreed to banking of the DNA. Persons aged 80 years and older and African-Americans were less likely to participate in APOE genotyping. Concern about confidentiality was the most common reason for not wanting to provide a DNA sample or to have DNA banked. CONCLUSION We found stronger relationships between sociodemographic variables of age and ethnicity with participation in genetic testing than we did between level of educational attainment, gender, function, cognition, and affect. PMID:15692195

Performance oriented guidance for Mississippi chip seals - volume II.

DOT National Transportation Integrated Search

2013-12-01

A laboratory and field study was conducted related to long term chip seal performance. This reports primary : objective was to initiate development of a long term performance (LTP) test protocol for chip seals focused on : aggregate retention. Key...

Desert Research and Technology Studies 2008 Report

NASA Technical Reports Server (NTRS)

Romig, Barbara; Kosmo, Joseph; Gernhardt, Michael; Abercromby, Andrew

2009-01-01

During the last two weeks of October 2008, the National Aeronautics and Space Administration (NASA) Johnson Space Center (JSC) Advanced Extravehicular Activity (AEVA) team led the field test portion of the 2008 Desert Research and Technology Studies (D-RATS) near Flagstaff, AZ. The Desert RATS field test activity is the year-long culmination of various individual science and advanced engineering discipline areas technology and operations development efforts into a coordinated field test demonstration under representative (analog) planetary surface terrain conditions. The 2008 Desert RATS was the eleventh RATS field test and was the most focused and successful test to date with participants from six NASA field centers, three research organizations, one university, and one other government agency. The main test objective was to collect Unpressurized Rover (UPR) and Lunar Electric Rover (LER) engineering performance and human factors metrics while under extended periods of representative mission-based scenario test operations involving long drive distances, night-time driving, Extravehicular Activity (EVA) operations, and overnight campover periods. The test was extremely successful with all teams meeting the primary test objective. This paper summarizes Desert RATS 2008 test hardware, detailed test objectives, test operations, and test results.

When apperceptive agnosia is explained by a deficit of primary visual processing.

PubMed

Serino, Andrea; Cecere, Roberto; Dundon, Neil; Bertini, Caterina; Sanchez-Castaneda, Cristina; Làdavas, Elisabetta

2014-03-01

Visual agnosia is a deficit in shape perception, affecting figure, object, face and letter recognition. Agnosia is usually attributed to lesions to high-order modules of the visual system, which combine visual cues to represent the shape of objects. However, most of previously reported agnosia cases presented visual field (VF) defects and poor primary visual processing. The present case-study aims to verify whether form agnosia could be explained by a deficit in basic visual functions, rather that by a deficit in high-order shape recognition. Patient SDV suffered a bilateral lesion of the occipital cortex due to anoxia. When tested, he could navigate, interact with others, and was autonomous in daily life activities. However, he could not recognize objects from drawings and figures, read or recognize familiar faces. He was able to recognize objects by touch and people from their voice. Assessments of visual functions showed blindness at the centre of the VF, up to almost 5°, bilaterally, with better stimulus detection in the periphery. Colour and motion perception was preserved. Psychophysical experiments showed that SDV's visual recognition deficits were not explained by poor spatial acuity or by the crowding effect. Rather a severe deficit in line orientation processing might be a key mechanism explaining SDV's agnosia. Line orientation processing is a basic function of primary visual cortex neurons, necessary for detecting "edges" of visual stimuli to build up a "primal sketch" for object recognition. We propose, therefore, that some forms of visual agnosia may be explained by deficits in basic visual functions due to widespread lesions of the primary visual areas, affecting primary levels of visual processing. Copyright © 2013 Elsevier Ltd. All rights reserved.

"Chance favors only the prepared mind": preparing minds to systematically reduce hazards in the testing process in primary care.

PubMed

Singh, Ranjit; Hickner, John; Mold, Jim; Singh, Gurdev

2014-03-01

Testing plays a vital role in primary care. Failures in the process are common and can be harmful. As the great 19th century microbiologist Louis Pasteur put it "chance favors only the prepared mind." Our objective is to prepare minds in primary care practices to improve safety in the testing process. Various principles from safety science can be applied. A prospective methodology that uses an anonymous practice survey based on concepts from failure modes and effects analysis is proposed. Responses are used to rank perceived hazards in the testing process, leading to prioritization of areas for intervention. Secondary data analysis (using data from a study of medication safety) was used to explore the value of this approach in the context of assessing the testing process. At 3 primary care practice sites, a total of 61 staff members completed 4 survey items examining the testing process. Comparison across practices shows that each has a distinct profile of hazards, which would lead each on a different path toward improvement. The proposed approach treats each practice as a unique complex adaptive system aiming to help it thrive by inculcating trust, mutual respect, and collaboration. Implications for patient safety research and practice are discussed.

Differences in the diagnosis and management of systemic lupus erythematosus by primary care and specialist providers in the American Indian/Alaska Native population.

PubMed

McDougall, J A; Helmick, C G; Lim, S S; Johnston, J M; Gaddy, J R; Gordon, C; Ferucci, E D

2018-06-01

Objectives The objective of this study is to investigate differences in the diagnosis and management of systemic lupus erythematosus (SLE) by primary care and specialist physicians in a population-based registry. Methods This study includes individuals from the 2009 Indian Health Service lupus registry population with a diagnosis of SLE documented by either a primary care provider or specialist. SLE classification criteria, laboratory testing, and medication use at any time during the course of disease were determined by medical record abstraction. Results Of the 320 individuals with a diagnosis of SLE, 249 had the diagnosis documented by a specialist, with 71 documented by primary care. Individuals with a specialist diagnosis of SLE were more likely to have medical record documentation of meeting criteria for SLE by all criteria sets (American College of Rheumatology, 79% vs 22%; Boston Weighted, 82% vs 32%; and Systemic Lupus International Collaborating Clinics, 83% vs 35%; p < 0.001 for all comparisons). In addition, specialist diagnosis was associated with documentation of ever having been tested for anti-double-stranded DNA antibody and complement 3 and complement 4 ( p < 0.001). Documentation of ever receiving hydroxychloroquine was also more common with specialist diagnosis (86% vs 64%, p < 0.001). Conclusions Within the population studied, specialist diagnosis of SLE was associated with a higher likelihood of having SLE classification criteria documented, being tested for biomarkers of disease, and ever receiving treatment with hydroxychloroquine. These data support efforts both to increase specialist access for patients with suspected SLE and to provide lupus education to primary care providers.

The Sensor Test for Orion RelNav Risk Mitigation Development Test Objective

NASA Technical Reports Server (NTRS)

Christian, John A.; Hinkel, Heather; Maguire, Sean

2011-01-01

The Sensor Test for Orion Relative-Navigation Risk Mitigation (STORRM) Development Test Objective (DTO) ew aboard the Space Shuttle Endeavour on STS-134, and was designed to characterize the performance of the ash LIDAR being developed for the Orion. This ash LIDAR, called the Vision Navigation Sensor (VNS), will be the primary navigation instrument used by the Orion vehicle during rendezvous, proximity operations, and docking. This paper provides an overview of the STORRM test objectives and the concept of operations. It continues with a description of the STORRM's major hardware compo nents, which include the VNS and the docking camera. Next, an overview of crew and analyst training activities will describe how the STORRM team prepared for flight. Then an overview of how insight data collection and analysis actually went is presented. Key ndings and results from this project are summarized, including a description of "truth" data. Finally, the paper concludes with lessons learned from the STORRM DTO.

Potential access to primary health care: what does the National Program for Access and Quality Improvement data show?

PubMed Central

Uchôa, Severina Alice da Costa; Arcêncio, Ricardo Alexandre; Fronteira, Inês Santos Estevinho; Coêlho, Ardigleusa Alves; Martiniano, Claudia Santos; Brandão, Isabel Cristina Araújo; Yamamura, Mellina; Maroto, Renata Melo

2016-01-01

Objective: to analyze the influence of contextual indicators on the performance of municipalities regarding potential access to primary health care in Brazil and to discuss the contribution from nurses working on this access. Method: a multicenter descriptive study based on secondary data from External Evaluation of the National Program for Access and Quality Improvement in Primary Care, with the participation of 17,202 primary care teams. The chi-square test of proportions was used to verify differences between the municipalities stratified based on size of the coverage area, supply, coordination, and integration; when necessary, the chi-square test with Yates correction or Fisher's exact test were employed. For the population variable, the Kruskal-Wallis test was used. Results: the majority of participants were nurses (n=15.876; 92,3%). Statistically significant differences were observed between the municipalities in terms of territory (p=0.0000), availability (p=0.0000), coordination of care (p=0.0000), integration (p=0.0000) and supply (p=0.0000), verifying that the municipalities that make up area 6 tend to have better performance in these dimensions. Conclusion: areas 4,5 and 6 performed better in every analyzed dimension, and the nurse had a leading role in the potential to access primary health care in Brazil. PMID:26959332

In Low-Income Schools, Parents Want Teachers Who Teach; In Affluent Schools, Other Things Matter

ERIC Educational Resources Information Center

Jacob, Brian; Lefgren, Lars

2007-01-01

Recent government education policies seem to assume that academic achievement as measured by test scores is the primary objective of public education. A prime example is the federal No Child Left Behind law, which requires schools to bring all of their students to "proficient" levels on math and reading tests by 2014. Many state…

Diagnostic Assessment of Preparedness of Level One Sports Science Students for Biomechanics Modules

ERIC Educational Resources Information Center

Dixon, Sharon J.

2005-01-01

The primary objective of this study was to investigate the use of a diagnostic test to assess the preparedness of level one students for a sports biomechanics module. During their first week at university, a cohort of 108 students completed a diagnostic test at the end of their first lecture in sports biomechanics, with no prior notice. Upon…

Improving the fatigue resistance of adhesive joints in laminated wood structures

NASA Technical Reports Server (NTRS)

Laufenberg, Theodore L.; River, Bryan H.; Murmanis, Lidija L.; Christiansen, Alfred W.

1988-01-01

The premature fatigue failure of a laminated wood/epoxy test beam containing a cross section finger joint was the subject of a multi-disciplinary investigation. The primary objectives were to identify the failure mechanisms which occurred during the finger joint test and to provide avenues for general improvements in the design and fabrication of adhesive joints in laminated wood structures.

Design values of resilient modulus of stabilized and non-stabilized base.

DOT National Transportation Integrated Search

2010-10-01

The primary objective of this research study is to determine design value ranges for typical base materials, as allowed by LADOTD specifications, through laboratory tests with respect to resilient modulus and other parameters used by pavement design ...

Recent Flight Test Results of the Joint CIAM-NASA Mach 6.5 Scramjet Flight Program

NASA Technical Reports Server (NTRS)

Roudakov, Alexander S.; Semenov, Vyacheslav L.; Hicks, John W.

1998-01-01

Under a contract with NASA, a joint Central Institute of Aviation Motors (CIAM) and NASA team recently conducted the fourth flight test of a dual-mode scramjet aboard the CIAM Hypersonic Flying Laboratory, 'Kholod'. With an aim test Mach 6.5 objective, the successful launch was conducted at the Sary Shagan test range in central Kazakstan on February 12, 1998. Ground-launch, rocket boosted by a modified Russian SA5 missile, the redesigned scramjet was accelerated to a new maximum velocity greater than Mach 6.4. This launch allowed for the measurement of the fully supersonic combustion mode under actual flight conditions. The primary program objective was the flight-to-ground correlation of measured data with preflight analysis and wind-tunnel tests in Russia and potentially in the United States. This paper describes the development and objectives of the program as well as the technical details of the scramjet and SA5 redesign to achieve the Mach 6.5 aim test condition. An overview of the launch operation is also given. Finally, preliminary flight test results are presented and discussed.

Cadmium Alternatives for High-Strength Steel JTP. Phase 2

DTIC Science & Technology

2007-01-24

Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 U.S. AIR FORCE Project Overview Objective Assess DoD- selected cadmium alternatives in...focused) – Phase III (fatigue testing focused) • Down- selection of candidates for further testing after each phase of testing is complete (Phases I...Laboratories – Mr. John Marshall U.S. AIR FORCE Phase I Overview and Selection Process – Traditional plating (primary coatings): • Sputtered Aluminum

Torque Tension Testing of Fasteners used for NASA Flight Hardware Applications

NASA Technical Reports Server (NTRS)

Hemminger, Edgar G.; Posey, Alan J.; Dube, Michael J.

2014-01-01

The effect of various lubricants and other compounds on fastener torque-tension relationships is evaluated. Testing was performed using a unique test apparatus developed by Posey at the NASA Goddard Space Flight Center. A description of the test methodology, including associated data collection and analysis will be presented. Test results for 300 series CRES and A286 heat resistant fasteners, torqued into various types of inserts will be presented. The primary objective of this testing was to obtain torque-tension data for use on NASA flight projects.

Effectiveness of a Risk Screener in Identifying Hepatitis C Virus in a Primary Care Setting

PubMed Central

Litwin, Alain H.; Smith, Bryce D.; Koppelman, Elisa A.; McKee, M. Diane; Christiansen, Cindy L.; Gifford, Allen L.; Weinbaum, Cindy M.; Southern, William N.

2012-01-01

Objectives. We evaluated an intervention designed to identify patients at risk for hepatitis C virus (HCV) through a risk screener used by primary care providers. Methods. A clinical reminder sticker prompted physicians at 3 urban clinics to screen patients for 12 risk factors and order HCV testing if any risks were present. Risk factor data were collected from the sticker; demographic and testing data were extracted from electronic medical records. We used the t test, χ2 test, and rank-sum test to compare patients who had and had not been screened and developed an analytic model to identify the incremental value of each element of the screener. Results. Among screened patients, 27.8% (n = 902) were identified as having at least 1 risk factor. Of screened patients with risk factors, 55.4% (n = 500) were tested for HCV. Our analysis showed that 7 elements (injection drug use, intranasal drug use, elevated alanine aminotransferase, transfusions before 1992, ≥ 20 lifetime sex partners, maternal HCV, existing liver disease) accounted for all HCV infections identified. Conclusions. A brief risk screener with a paper-based clinical reminder was effective in increasing HCV testing in a primary care setting. PMID:22994166

Design assurance test of the Thiokol Te-M-521-5 apogee kick motor tested in the spin mode at simulated altitude conditions

NASA Technical Reports Server (NTRS)

Cimino, A. A.

1973-01-01

One Thiokol Chemical Corporation TE-M-521-5 solid-propellant apogee rocket motor was successfully fired at an average simulated altitude of about 108,000 ft while spinning at 46 rpm. The general program objectives were to verify compliance of motor performance with the manufacturer's specifications. Specific primary objectives were to determine vacuum ballistic performance of the motor after prefire vibration conditioning and temperature conditioning at 40F, altitude ignition characteristics, motor structural integrity, and motor temperature-time history during and after motor operation. Additional objectives were to measure the lateral (nonaxial) thrust component during motor operation and to measure radiation heat flux in the vicinity of the nozzle exit plane.

Diagnostic and laboratory test ordering in Northern Portuguese Primary Health Care: a cross-sectional study

PubMed Central

Sá, Luísa; Teixeira, Andreia Sofia Costa; Tavares, Fernando; Costa-Santos, Cristina; Couto, Luciana; Costa-Pereira, Altamiro; Hespanhol, Alberto Pinto; Santos, Paulo

2017-01-01

Objectives To characterise the test ordering pattern in Northern Portugal and to investigate the influence of context-related factors, analysing the test ordered at the level of geographical groups of family physicians and at the level of different healthcare organisations. Design Cross-sectional study. Setting Northern Primary Health Care, Portugal. Participants Records about diagnostic and laboratory tests ordered from 2035 family physicians working at the Northern Regional Health Administration, who served approximately 3.5 million Portuguese patients, in 2014. Outcomes To determine the 20 most ordered diagnostic and laboratory tests in the Northern Regional Health Administration; to identify the presence and extent of variations in the 20 most ordered diagnostic and laboratory tests between the Groups of Primary Care Centres and between health units; and to study factors that may explain these variations. Results The 20 most ordered diagnostic and laboratory tests almost entirely comprise laboratory tests and account for 70.9% of the total tests requested. We can trace a major pattern of test ordering for haemogram, glucose, lipid profile, creatinine and urinalysis. There was a significant difference (P<0.001) in test orders for all tests between Groups of Primary Care Centres and for all tests, except glycated haemoglobin (P=0.06), between health units. Generally, the Personalised Healthcare Units ordered more than Family Health Units. Conclusions The results from this study show that the most commonly ordered tests in Portugal are laboratory tests, that there is a tendency for overtesting and that there is a large variability in diagnostic and laboratory test ordering in different geographical and organisational Portuguese primary care practices, suggesting that there may be considerable potential for the rationalisation of test ordering. The existence of Family Health Units seems to be a strong determinant in decreasing test ordering by Portuguese family physicians. Approaches to ensuring more rational testing are needed. PMID:29146654

Planned flight test of a mercury ion auxiliary propulsion system. 1: Objectives, systems descriptions, and mission operations

NASA Technical Reports Server (NTRS)

Power, J. C.

1978-01-01

A planned flight test of an 8 cm diameter, electron-bombardment mercury ion thruster system is described. The primary objective of the test is to flight qualify the 5 mN (1 mlb.) thruster system for auxiliary propulsion applications. A seven year north-south stationkeeping mission was selected as the basis for the flight test operating profile. The flight test, which will employ two thruster systems, will also generate thruster system space performance data, measure thruster-spacecraft interactions, and demonstrate thruster operation in a number of operating modes. The flight test is designated as SAMSO-601 and will be flown aboard the shuttle-launched Air Force space test program P80-1 satellite in 1981. The spacecraft will be 3- axis stabilized in its final 740 km circular orbit, which will have an inclination of approximately greater than 73 degrees. The spacecraft design lifetime is three years.

Input Range Testing for the General Mission Analysis Tool (GMAT)

NASA Technical Reports Server (NTRS)

Hughes, Steven P.

2007-01-01

This document contains a test plan for testing input values to the General Mission Analysis Tool (GMAT). The plan includes four primary types of information, which rigorously define all tests that should be performed to validate that GMAT will accept allowable inputs and deny disallowed inputs. The first is a complete list of all allowed object fields in GMAT. The second type of information, is test input to be attempted for each field. The third type of information is allowable input values for all objects fields in GMAT. The final piece of information is how GMAT should respond to both valid and invalid information. It is VERY important to note that the tests below must be performed for both the Graphical User Interface and the script!! The examples are illustrated using a scripting perspective, because it is simpler to write up. However, the test must be performed for both interfaces to GMAT.

Tranexamic Acid as Antifibrinolytic Agent in Non Traumatic Intracerebral Hemorrhages

PubMed Central

ARUMUGAM, Ananda; A RAHMAN, Noor Azman; THEOPHILUS, Sharon Casilda; SHARIFFUDIN, Ashraf; ABDULLAH, Jafri Malin

2015-01-01

Background: Mortality and morbidity associated with intracerebral hemorrhage is still high. Up to now, there are no evidence-based effective treatments for acute ICH. This study is to assess the effect of tranexamic acid (TXA) on hematoma growth of patients with spontaneous ICH compared to a placebo. Methods: We performed a single-blinded, randomised placebo-controlled trial of TXA (intravenous 1g bolus, followed by infusion TXA 1 g/hour for 8 hours) in acute (< 8 hours) primary ICH. Strict blood pressure control (target SBP 140-160 mmHg). A repeat Computed Tomography brain was done after 24 hours to reassess hematoma growth. The primary objective is to test the effect of TXA on hematoma growth. Other objective was to test the feasibility, tolerability, and adverse events of TXA in primary ICH. Results: Statistical analysis showed significant hematoma growth in control group after 24 hours compared to baseline (14.3300 vs 17.9940, P = 0.001) whereas the treatment group there is no significant hematoma size expansion between baseline and after 24 hours (P = 0.313). Conclusions: This study showed a significant hematoma volume expansion in the control group compared to the treatment group. PMID:27006639

Tranexamic Acid as Antifibrinolytic Agent in Non Traumatic Intracerebral Hemorrhages.

PubMed

Arumugam, Ananda; A Rahman, Noor Azman; Theophilus, Sharon Casilda; Shariffudin, Ashraf; Abdullah, Jafri Malin

2015-12-01

Mortality and morbidity associated with intracerebral hemorrhage is still high. Up to now, there are no evidence-based effective treatments for acute ICH. This study is to assess the effect of tranexamic acid (TXA) on hematoma growth of patients with spontaneous ICH compared to a placebo. We performed a single-blinded, randomised placebo-controlled trial of TXA (intravenous 1g bolus, followed by infusion TXA 1 g/hour for 8 hours) in acute (< 8 hours) primary ICH. Strict blood pressure control (target SBP 140-160 mmHg). A repeat Computed Tomography brain was done after 24 hours to reassess hematoma growth. The primary objective is to test the effect of TXA on hematoma growth. Other objective was to test the feasibility, tolerability, and adverse events of TXA in primary ICH. Statistical analysis showed significant hematoma growth in control group after 24 hours compared to baseline (14.3300 vs 17.9940, P = 0.001) whereas the treatment group there is no significant hematoma size expansion between baseline and after 24 hours (P = 0.313). This study showed a significant hematoma volume expansion in the control group compared to the treatment group.

Colorectal cancer screening practices of primary care providers: results of a national survey in Malaysia.

PubMed

Norwati, Daud; Harmy, Mohamed Yusoff; Norhayati, Mohd Noor; Amry, Abdul Rahim

2014-01-01

The incidence of colorectal cancer has been increasing in many Asian countries including Malaysia during the past few decades. A physician recommendation has been shown to be a major factor that motivates patients to undergo screening. The present study objectives were to describe the practice of colorectal cancer screening by primary care providers in Malaysia and to determine the barriers for not following recommendations. In this cross sectional study involving 132 primary care providers from 44 Primary Care clinics in West Malaysia, self-administered questionnaires which consisted of demographic data, qualification, background on the primary care clinic, practices on colorectal cancer screening and barriers to colorectal cancer screening were distributed. A total of 116 primary care providers responded making a response rate of 87.9%. About 21% recommended faecal occult blood test (FOBT) in more than 50% of their patients who were eligible. The most common barrier was "unavailability of the test". The two most common patient factors are "patient in a hurry" and "poor patient awareness". This study indicates that colorectal cancer preventive activities among primary care providers are still poor in Malaysia. This may be related to the low availability of the test in the primary care setting and poor awareness and understanding of the importance of colorectal cancer screening among patients. More awareness programmes are required for the public. In addition, primary care providers should be kept abreast with the latest recommendations and policy makers need to improve colorectal cancer screening services in health clinics.

Investigation of premature distress in conventional asphalt materials on Interstate 10 at Columbus, Texas.

DOT National Transportation Integrated Search

1982-08-01

The primary objectives of the study were to determine the probable causes of the distress and to make recommendations which could alleviate future problems. The investigation involved an analysis of construction records and laboratory test results pe...

Tests of HMA overlays using geosynthetics to reduce reflection cracking.

DOT National Transportation Integrated Search

2009-12-01

The primary objective of this field phase of the research project was to evaluate geosynthetic : products placed under or within hot mix asphalt overlays to reduce the severity or delay the appearance of : reflection cracks and to calibrate and valid...

Evaluation of waste concrete road materials for use in oyster aquaculture.

DOT National Transportation Integrated Search

2013-02-01

The primary objective of this study was to determine the suitability of recycled concrete : aggregate (RCA) from road projects as bottom conditioning material for on-bottom oyster : aquaculture in the Chesapeake Bay. The testing was designed to (1) e...

A comparison of the legibility and visibility of enamel and reflectorized 1971 Virginia license plates.

DOT National Transportation Integrated Search

1971-01-01

The Safety Section of the Virginia Highway Research. Council carried out observation tests of the legibility and visibility of reflectorized and enamel license plates. The primary objectives were to determine the comparative legibility and visibility...

Flight Tests of a Ministick Controller in an F/A-18 Airplane

NASA Technical Reports Server (NTRS)

Stoliker, Patrick C.; Carter, John

2003-01-01

In March of 1999, five pilots performed flight tests to evaluate the handling qualities of an F/A-18 research airplane equipped with a small-displacement center stick (ministick) controller that had been developed for the JAS 39 Gripen airplane (a fighter/attack/ reconnaissance airplane used by the Swedish air force). For these tests, the ministick was installed in the aft cockpit (see figure) and production support flight control computers (PSFCCs) were used as interfaces between the controller hardware and the standard F/A-18 flight-control laws. The primary objective of the flight tests was to assess any changes in handling qualities of the F/A-18 airplane attributable to the mechanical characteristics of the ministick. The secondary objective was to demonstrate the capability of the PSFCCs to support flight-test experiments.

NASA Ares I Launch Vehicle First Stage Roll Control System Cold Flow Development Test Program Overview

NASA Technical Reports Server (NTRS)

Butt, Adam; Popp, Christopher G.; Holt, Kimberly A.; Pitts, Hank M.

2010-01-01

The Ares I launch vehicle is the selected design, chosen to return humans to the moon, Mars, and beyond. It is configured in two inline stages: the First Stage is a Space Shuttle derived five-segment Solid Rocket Booster and the Upper Stage is powered by a Saturn V derived J-2X engine. During launch, roll control for the First Stage (FS) is handled by a dedicated Roll Control System (RoCS) located on the connecting Interstage. That system will provide the Ares I with the ability to counteract induced roll torque while any induced yaw or pitch moments are handled by vectoring of the booster nozzle. This paper provides an overview of NASA s Ares I FS RoCS cold flow development test program including detailed test objectives, types of tests run to meet those objectives, an overview of the results, and applicable lessons learned. The test article was built and tested at the NASA Marshall Space Flight Center in Huntsville, AL. The FS RoCS System Development Test Article (SDTA) is a full scale, flight representative water flow test article whose primary objective was to obtain fluid system performance data to evaluate integrated system level performance characteristics and verify analytical models. Development testing and model correlation was deemed necessary as there is little historical precedent for similar large flow, pulsing systems such as the FS RoCS. The cold flow development test program consisted of flight-similar tanks, pressure regulators, and thruster valves, as well as plumbing simulating flight geometries, combined with other facility grade components and structure. Orifices downstream of the thruster valves were used to simulate the pressure drop through the thrusters. Additional primary objectives of this test program were to: evaluate system surge pressure (waterhammer) characteristics due to thruster valve operation over a range of mission duty cycles at various feed system pressures, evaluate temperature transients and heat transfer in the pressurization system, including regulator blowdown and propellant ullage performance, measure system pressure drops for comparison to analysis of tubing and components, and validate system activation and re-activation procedures for the helium pressurant system. Secondary objectives included: validating system processes for loading, unloading, and purging, validating procedures and system response for multiple failure scenarios, including relief valve operation, and evaluating system performance for contingency scenarios. The test results of the cold flow development test program are essential in validating the performance and interaction of the Roll Control System and anchoring analysis tools and results to a Critical Design Review level of fidelity.

Tank 241-AZ-101 Mixer Pump Test Vapor Sampling and Analysis Plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

TEMPLETON, A.M.

2000-03-06

This sampling and analysis plan (SAP) identifies characterization objectives pertaining to sample collection, laboratory analytical evaluation, and reporting requirements for vapor samples obtained during the operation of mixer pumps in tank 241-AZ-101. The primary purpose of the mixer pump test (MPT) is to demonstrate that the two 300 horsepower mixer pumps installed in tank 241-AZ-101 can mobilize the settled sludge so that it can be retrieved for treatment and vitrification. Sampling will be performed in accordance with Tank 241-AZ-101 Mixer Pump Test Data Quality Objective (Banning 1999) and Data Quality Objectives for Regulatory Requirements for Hazardous and Radioactive Air Emissionsmore » Sampling and Analysis (Mulkey 1999). The sampling will verify if current air emission estimates used in the permit application are correct and provide information for future air permit applications.« less

Tank 241-AZ-101 Mixer Pump Test Vapor Sampling and Analysis Plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

TEMPLETON, A.M.

2000-01-31

This sampling and analysis plan (SAP) identifies characterization objectives pertaining to sample collection, laboratory analytical evaluation, and reporting requirements for vapor samples obtained during the operation of mixer pumps in tank 241-AZ-101. The primary purpose of the mixer pump test (MPT) is to demonstrate that the two 300 horsepower mixer pumps installed in tank 241-AZ-101 can mobilize the settled sludge so that it can be retrieved for treatment and vitrification Sampling will be performed in accordance with Tank 241-AZ-101 Mixer Pump Test Data Quality Objective (Banning 1999) and Data Quality Objectives for Regulatory Requirements for Hazardous and Radioactive Air Emissionsmore » Sampling and Analysis (Mulkey 1999). The sampling will verify if current air emission estimates used in the permit application are correct and provide information for future air permit applications.« less

Tank 241-AZ-101 Mixer Pump Test Vapor Sampling and Analysis Plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

TEMPLETON, A.M.

2000-04-10

This sampling and analysis plan (SAP) identifies characterization objectives pertaining to sample collection, laboratory analytical evaluation, and reporting requirements for vapor samples obtained during the operation of mixer pumps in tank 241-AZ-101. The primary purpose of the mixer pump test (MPT) is to demonstrate that the two 300 horsepower mixer pumps installed in tank 241-AZ-101 can mobilize the settled sludge so that it can be retrieved for treatment and vitrification. Sampling will be performed in accordance with Tank 241-AZ-101 Mixer Pump Test Data Quality Objective (Banning 1999) and Data Quality Objectives for Regulatory Requirements for Hazardous and Radioactive Air Emissionsmore » Sampling and Analysis (Mulkey 1999). The sampling will verify if current air emission estimates used in the permit application are correct and provide information for future air permit applications.« less

[Cystatin C as a mortality predictor in a hypertensive population in Extremadura, Spain].

PubMed

Garcia Gallego, Francisco; Robles, Nicolás Roberto; Matias Orozco, Nicolás; Mena, Candido; Cidoncha, Antonio

2015-09-07

Cystatin C has proven to be a useful parameter to evaluate renal and cardiovascular risk. Nevertheless, there are scanty reports on the utility of this test in the Spanish population. We performed a survey in a group of patients followed up in Primary Care settings. Prospective follow up of Primary Care attended patients recruited in 2008 and the first half of 2009. The sample included 142 subjects (mean age 64.2±14.6 years, 59.2% men). In all cases, cystatin C was determined and glomerular filtration rate (GFR) was estimated through the Hoek formula. Serum creatinine was also quantified as it was GFR estimated using CKD-EPI equation. The primary objective was a combination of death and major cardiovascular events incidence. There were 29 events registered (4 of them were deaths) and 9 non cardiovascular deaths. The odds ratio for the primary objective was 5.74 for the last quartile of cystatin C distribution (>1mg/l) (P=.002), while it was 6.44 for cystatin C derived GFR (P=.008) and 5.59 for CKD-EPI estimated GFR (P=.002, Mantel-Haenszel test). Cystatin C showed a good association with general mortality and the incidence of cardiovascular events in the Spanish population. Nevertheless, it was not better than the observed relationship with GFR, estimated from creatinine. Copyright © 2015 Elsevier España, S.L.U. All rights reserved.

Operation REDWING. Technical Summary of Military Effects. Programs 1-9

DTIC Science & Technology

1981-05-15

study chorioretinal burns. The primary objective of the program on effects on aircraft structures was to ascer- tain the reliability of current weapons...other aircraft. In the program of tests on service equipment and studies of electromagnetic effects,I 4k. the emphasis was placed on studying long...range detection of nuclear explosions. An additional objective was the study of the effects of nuclear detonations on the ionosphere and microwave

Electrical Evolution of a Dust Plume from a Low Energy Lunar Impact: A Model Analog to LCROSS

NASA Technical Reports Server (NTRS)

Farrell, W. M.; Stubbs, T. J.; Jackson, T. L.; Colaprete, A.; Heldmann, J. L.; Schultz, P. H.; Killen, R. M.; Delory, G. T.; Halekas, J. S.; Marshall, J. R.;

The 5K70SK automatically tuned, high power, S-band klystron

NASA Technical Reports Server (NTRS)

Goldfinger, A.

1977-01-01

Primary objectives include delivery of 44 5K70SK klystron amplifier tubes and 26 remote tuner assemblies with spare parts kits. Results of a reliability demonstration on a klystron test cavity are discussed, along with reliability tests performed on a remote tuning unit. Production problems and one design modification are reported and discussed. Results of PAT and DVT are included.

Atomization and Mixing Study

NASA Technical Reports Server (NTRS)

Ferrenberg, A.; Hunt, K.; Duesberg, J.

1985-01-01

The primary objective was the obtainment of atomization and mixing performance data for a variety of typical liquid oxygen/hydrocarbon injector element designs. Such data are required to establish injector design criteria and to provide critical inputs to liquid rocket engine combustor performance and stability analysis, and computational codes and methods. Deficiencies and problems with the atomization test equipment were identified, and action initiated to resolve them. Test results of the gas/liquid mixing tests indicated that an assessment of test methods was required. A series of 71 liquid/liquid tests were performed.

Pilot, a balloon borne experiment underground tests

NASA Astrophysics Data System (ADS)

Engel, C.; Marty, C.; Mot, B.; Bernard, J.-Ph.; Ristorcelli, I.; Otrio, G.; Leriche, B.; Longval, Y.; Pajot, F.; Roudil, G.; Caillat, A.; Dubois, J. P.; Bouzit, M.; Buttice, V.; Camus, T.

2017-11-01

PILOT is a balloon borne experiment, which will measure the polarized emission of dust grains, in the interstellar medium, in the sub millimeter range (with two photometric channels centered at 240 and 550 μm). The primary and secondary mirror must be positioned with accuracies better than 0.6 mm and 0.06°. These tolerances include environmental conditions (mainly gravity and thermo-elastic effects), uncertainties on alignments, and uncertainties on the dilatation coefficient. In order to respect these tolerances, we need precise characterization of each optical component. The characterization of the primary mirror and the integrated instrument is performed using a dedicated submillimeter test bench. A brief description of the scientific objectives and instrumental concept is given in the first part. We present, in the second and in the third part, the status of these ground tests, first results and planned tests.

Primary Cytomegalovirus Infection in Pregnant Egyptian Women Confirmed by Cytomegalovirus IgG Avidity Testing

PubMed Central

Kamel, N.; Metwally, L.; Gomaa, N.; Sayed Ahmed, W.A.; Lotfi, M.; Younis, S.

2013-01-01

Objective To determine the frequency of primary cytomegalovirus (CMV) infection in pregnant Egyptian women using CMV IgG avidity testing. Subjects and Methods A cross-sectional study was conducted at Suez Canal University Hospital, Ismailia, Egypt. A total of 546 pregnant women, presenting for routine antenatal screening, were tested for CMV IgG and IgM using a commercially available enzyme-linked immunosorbent assay (ELISA). Sera from CMV IgM-positive women were tested by CMV IgG avidity assay. Results All the 546 pregnant women were seropositive for anti-CMV IgG. Of the 546 women, 40 (7.3%) were positive or equivocal for IgM antibodies. All sera from the 40 women (IgG+/IgM+) showed a high or intermediate CMV IgG avidity index. Of the 40 women, 23 (57.5%) were in the second or third trimesters of pregnancy and had their first-trimester blood retrieved, and the tested CMV IgG avidity assay showed a high avidity index. Conclusion Women who were IgM positive had no primary CMV infection in the index pregnancy as evidenced by the high CMV IgG avidity testing. PMID:24052007

Lactobacillus helveticus-fermented milk improves learning and memory in mice.

PubMed

Ohsawa, Kazuhito; Uchida, Naoto; Ohki, Kohji; Nakamura, Yasunori; Yokogoshi, Hidehiko

2015-07-01

To investigate the effects of Calpis sour milk whey, a Lactobacillus helveticus-fermented milk product, on learning and memory. We evaluated improvement in scopolamine-induced memory impairment using the spontaneous alternation behaviour test, a measure of short-term memory. We also evaluated learning and working memory in mice using the novel object recognition test, which does not involve primary reinforcement (food or electric shocks). A total of 195 male ddY mice were used in the spontaneous alternation behaviour test and 60 in the novel object recognition test. Forced orally administered Calpis sour milk whey powder (200 and 2000 mg/kg) significantly improved scopolamine-induced cognitive impairments (P < 0.05 and P < 0.01, respectively) and object recognition memory (2000 mg/kg; P < 0.05). These results suggest that Calpis sour milk whey may be useful for the prevention of neurodegenerative disorders, such as Alzheimer's disease, and enhancing learning and memory in healthy human subjects; however, human clinical studies are necessary.

First flush reactor for stormwater treatment for elevated linear transportation projects : technical summary.

DOT National Transportation Integrated Search

2009-06-01

The primary objective of this study was to design and test a first flush-based stormwater treatment device for elevated linear transportation projects/roadways that is capable of complying with MS4 regulations. The innovative idea behind the device i...

Joint Test Protocol for Validation of Alternatives to Aliphatic Isocyanate Polyurethanes

NASA Technical Reports Server (NTRS)

Lewis, Pattie

2005-01-01

The primary objective of this effort is to demonstrate and validate alternatives to aliphatic isocyanate polyurethanes. Successful completion of this project will result in one or more isocyanate-free coatings qualified for use at AFSPC and NASA installations participating in this project.

Cost benefit analysis of anti-strip additives in hot mix asphalt with various aggregates.

DOT National Transportation Integrated Search

2015-05-01

This report documents research on moisture sensitivity testing of hot-mix asphalt (HMA) mixes in Pennsylvania and the : associated use of antistrip. The primary objective of the research was to evaluate and compare benefit/cost ratios of mandatory us...

Regression Analysis: Instructional Resource for Cost/Managerial Accounting

ERIC Educational Resources Information Center

Stout, David E.

2015-01-01

This paper describes a classroom-tested instructional resource, grounded in principles of active learning and a constructivism, that embraces two primary objectives: "demystify" for accounting students technical material from statistics regarding ordinary least-squares (OLS) regression analysis--material that students may find obscure or…

Development and Testing of a Prototype Connected Vehicle Wrong-Way Driving Detection and Management System

DOT National Transportation Integrated Search

2018-02-01

The primary objective of Phase II was to develop a prototype connected vehicle wrong-way driving detection and management system at the Texas A&M University Respect, Excellence, Leadership, Loyalty, Integrity, Selfless Service (RELLIS) campus. The pu...

PERFORMANCE MONITORING OF ENHANCED IN-SITU BIOREMEDIATION OF MTBE IN GROUND WATER

EPA Science Inventory

The primary objective of the Biostimulation Technology Evaluation was to determine if enhanced biodegradation was occurring in a ground-water test plot to a sufficient degree to reduce intrinsic methyl tertiary butyl ether (MTBE) to the State of California's treatability criteria...

Pathogen-tested, or certified planting material

USDA-ARS?s Scientific Manuscript database

Certification programs have been developed to provide plant material that meets a predetermined level of plant health. The primary objective of these programs is to limit pathogen incidence in plant material in order to minimize losses by growers. For many fruit and nut crops plantings are expecte...

Design and Development of High Voltage Direct Current (DC) Sources for the Solar Array Module Plasma Interaction Experiment

NASA Technical Reports Server (NTRS)

Bibyk, Irene K.; Wald, Lawrence W.

1995-01-01

Two programmable, high voltage DC power supplies were developed as part of the flight electronics for the Solar Array Module Plasma Interaction Experiment (SAMPIE). SAMPIE's primary objectives were to study and characterize the high voltage arcing and parasitic current losses of various solar cells and metal samples within the space plasma of low earth orbit (LEO). High voltage arcing can cause large discontinuous changes in spacecraft potential which lead to damage of the power system materials and significant Electromagnetic Interference (EMI). Parasitic currents cause a change in floating potential which lead to reduced power efficiency. These primary SAMPIE objectives were accomplished by applying artificial biases across test samples over a voltage range from -600 VDC to +300 VDC. This paper chronicles the design, final development, and test of the two programmable high voltage sources for SAMPIE. The technical challenges to the design for these power supplies included vacuum, space plasma effects, thermal protection, Shuttle vibrations and accelerations.

Association between Electronic Health Records and Health Care Utilization

PubMed Central

Edwards, A.; Kern, L.M.

2015-01-01

Summary Background The federal government is investing approximately $20 billion in electronic health records (EHRs), in part to address escalating health care costs. However, empirical evidence that provider use of EHRs decreases health care costs is limited. Objective To determine any association between EHRs and health care utilization. Methods We conducted a cohort study (2008–2009) in the Hudson Valley, a multi-payer, multiprovider community in New York State. We included 328 primary care physicians in predominantly small practices (median practice size four primary care physicians), who were caring for 223,772 patients. Data from an independent practice association was used to determine adoption of EHRs. Claims data aggregated across five commercial health plans was used to characterize seven types of health care utilization: primary care visits, specialist visits, radiology tests, laboratory tests, emergency department visits, hospital admissions, and readmissions. We used negative binomial regression to determine associations between EHR adoption and each utilization outcome, adjusting for ten physician characteristics. Results Approximately half (48%) of the physicians were using paper records and half (52%) were using EHRs. For every 100 patients seen by physicians using EHRs, there were 14 fewer specialist visits (adjusted p < 0.01) and 9 fewer radiology tests (adjusted p = 0.01). There were no significant differences in rates of primary care visits, laboratory tests, emergency department visits, hospitalizations or readmissions. Conclusions Patients of primary care providers who used EHRs were less likely to have specialist visits and radiology tests than patients of primary care providers who did not use EHRs. PMID:25848412

Active and passive spatial learning in human navigation: acquisition of graph knowledge.

PubMed

Chrastil, Elizabeth R; Warren, William H

2015-07-01

It is known that active exploration of a new environment leads to better spatial learning than does passive visual exposure. We ask whether specific components of active learning differentially contribute to particular forms of spatial knowledge-the exploration-specific learning hypothesis. Previously, we found that idiothetic information during walking is the primary active contributor to metric survey knowledge (Chrastil & Warren, 2013). In this study, we test the contributions of 3 components to topological graph and route knowledge: visual information, idiothetic information, and cognitive decision making. Four groups of participants learned the locations of 8 objects in a virtual hedge maze by (a) walking or (b) watching a video, crossed with (1) either making decisions about their path or (2) being guided through the maze. Route and graph knowledge were assessed by walking in the maze corridors from a starting object to the remembered location of a test object, with frequent detours. Decision making during exploration significantly contributed to subsequent route finding in the walking condition, whereas idiothetic information did not. Participants took novel routes and the metrically shortest routes on the majority of both direct and barrier trials, indicating that labeled graph knowledge-not merely route knowledge-was acquired. We conclude that, consistent with the exploration-specific learning hypothesis, decision making is the primary component of active learning for the acquisition of topological graph knowledge, whereas idiothetic information is the primary component for metric survey knowledge. (c) 2015 APA, all rights reserved.

Solar hot water systems application to the solar building test facility and the Tech House

NASA Technical Reports Server (NTRS)

Goble, R. L.; Jensen, R. N.; Basford, R. C.

1976-01-01

Projects which relate to the current national thrust toward demonstrating applied solar energy are discussed. The first project has as its primary objective the application of a system comprised of a flat plate collector field, an absorption air conditioning system, and a hot water heating system to satisfy most of the annual cooling and heating requirements of a large commercial office building. The other project addresses the application of solar collector technology to the heating and hot water requirements of a domestic residence. In this case, however, the solar system represents only one of several important technology items, the primary objective for the project being the application of space technology to the American home.

School environments and physical activity: the development and testing of an audit tool

PubMed Central

Jones, Natalia R; Jones, Andy; van Sluijs, Esther MF; Panter, Jenna; Harrison, Flo; Griffin, Simon J

2013-01-01

The aim of this study was to develop, test, and employ an audit tool to objectively assess the opportunities for physical activity within school environments. A 44 item tool was developed and tested at 92 primary schools in the county of Norfolk, England, during summer term of 2007. Scores from the tool covering 6 domains of facility provision were examined against objectively measured hourly moderate to vigorous physical activity levels in 1868 9-10 year old pupils attending the schools. The tool was found to have acceptable reliability and good construct validity, differentiating the physical activity levels of children attending the highest and lowest scoring schools. The characteristics of school grounds may influence pupil’s physical activity levels. PMID:20435506

Multitarget transcranial direct current stimulation for freezing of gait in Parkinson's disease.

PubMed

Dagan, Moria; Herman, Talia; Harrison, Rachel; Zhou, Junhong; Giladi, Nir; Ruffini, Giulio; Manor, Brad; Hausdorff, Jeffrey M

2018-04-01

Recent findings suggest that transcranial direct current stimulation of the primary motor cortex may ameliorate freezing of gait. However, the effects of multitarget simultaneous stimulation of motor and cognitive networks are mostly unknown. The objective of this study was to evaluate the effects of multitarget transcranial direct current stimulation of the primary motor cortex and left dorsolateral prefrontal cortex on freezing of gait and related outcomes. Twenty patients with Parkinson's disease and freezing of gait received 20 minutes of transcranial direct current stimulation on 3 separate visits. Transcranial direct current stimulation targeted the primary motor cortex and left dorsolateral prefrontal cortex simultaneously, primary motor cortex only, or sham stimulation (order randomized and double-blinded assessments). Participants completed a freezing of gait-provoking test, the Timed Up and Go, and the Stroop test before and after each transcranial direct current stimulation session. Performance on the freezing of gait-provoking test (P = 0.010), Timed Up and Go (P = 0.006), and the Stroop test (P = 0.016) improved after simultaneous stimulation of the primary motor cortex and left dorsolateral prefrontal cortex, but not after primary motor cortex only or sham stimulation. Transcranial direct current stimulation designed to simultaneously target motor and cognitive regions apparently induces immediate aftereffects in the brain that translate into reduced freezing of gait and improvements in executive function and mobility. © 2018 International Parkinson and Movement Disorder Society. © 2018 International Parkinson and Movement Disorder Society.

Development of guidance on the timeliness in response to acute kidney injury warning stage test results for adults in primary care: an appropriateness ratings evaluation

PubMed Central

Blakeman, Tom; Griffith, Kathryn; Lasserson, Dan; Lopez, Berenice; Tsang, Jung Y; Campbell, Stephen; Tomson, Charles

2016-01-01

Objectives Tackling the harm associated with acute kidney injury (AKI) is a global priority. In England, a national computerised AKI algorithm is being introduced across the National Health Service (NHS) to drive this change. The study sought to maximise its clinical utility and minimise the potential for burden on clinicians and patients in primary care. Design An appropriateness ratings evaluation using the RAND/UCLA Appropriateness Method. Setting Clinical scenarios were developed to test the timeliness in (1) communication of AKI warning stage test results from clinical pathology services to primary care, and (2) primary care clinician response to an AKI warning stage test result. Participants A 10-person panel was purposively sampled with representation from clinical biochemistry, acute and emergency medicine and general practice. General practitioners (GPs) represented typical practice in relation to rural and urban practice, out of hours care, GP commissioning and those interested in reducing the impact of medicalisation and ‘overdiagnosis’. Results There was agreement that delivery of AKI warning stage test results through interruptive methods of communication (ie, telephone) from laboratories to primary care was the appropriate next step for patients with an AKI warning stage 3 test result. In the context of acute illness, waiting up to 72 hours to respond to an AKI warning stage test result was deemed an inappropriate action in 62 out of the 65 (94.5%) cases. There was agreement that a clinician response was required within 6 hours, or less, in 39 out of 40 (97.5%) clinical cases relating AKI warning stage test results in the presence of moderate hyperkalaemia. Conclusions The study has informed national guidance to support a timely and calibrated response to AKI warning stage test results for adults in primary care. Further research is needed to support effective implementation, with a view to examine the effect on health outcomes and costs. PMID:27729353

Blood drop size in passive dripping from weapons.

PubMed

Kabaliuk, N; Jermy, M C; Morison, K; Stotesbury, T; Taylor, M C; Williams, E

2013-05-10

Passive dripping, the slow dripping of blood under gravity, is responsible for some bloodstains found at crime scenes, particularly drip trails left by a person moving through the scene. Previous work by other authors has established relationships, under ideal conditions, between the size of the stain, the number of spines and satellite stains, the roughness of the surface, the size of the blood droplet and the height from which it falls. To apply these relationships to infer the height of fall requires independent knowledge of the size of the droplet. This work aims to measure the size of droplets falling from objects representative of hand-held weapons. Pig blood was used, with density, surface tension and viscosity controlled to fall within the normal range for human blood. Distilled water was also tested as a reference. Drips were formed from stainless steel objects with different roughnesses including cylinders of diameter between 10 and 100 mm, and flat plates. Small radius objects including a knife and a wrench were also tested. High speed images of the falling drops were captured. The primary blood drop size ranged from 4.15±0.11 mm up to 6.15±0.15 mm (depending on the object), with the smaller values from sharper objects. The primary drop size correlated only weakly with surface roughness, over the roughness range studied. The number of accompanying droplets increased with the object size, but no significant correlation with surface texture was observed. Dripping of blood produced slightly smaller drops, with more accompanying droplets, than dripping water. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

James Webb Space Telescope: The First Light Machine

NASA Technical Reports Server (NTRS)

Stahl, H. Philip

2014-01-01

NASA James Webb Space Telescope (JWST) will search for the first luminous objects of the Universe to help answer fundamental questions about how the Universe came to look like it does today. At 6.5 meters in diameter, JWST will be the world's largest space telescope. Its architecture, e.g. aperture, wavelength range and operating temperature, is driven by JWST's science objectives. Introduction: Scheduled to start its 5 year mission after 2018, JWST will study the origin and evolution of galaxies, stars and planetary systems. Its science mission is to: Identify the first bright objects that formed in the early Universe, and follow the ionization history. Determine how galaxies form. Determine how galaxies and dark matter, including gas, stars, metals, overall morphology and active nuclei evolved to the present day. Observe the birth and early development of stars and the formation of planets. And, study the physical and chemical properties of solar systems for the building blocks of Life. Principle: To accomplish the JWST science objectives requires a larger aperture infrared cryogenic space telescope. A large aperture is required because the objects are very faint. The infrared spectral range is required because the objects are so far away that their ultraviolet and visible wavelength spectral lines are red-shifted into the infrared. Because the telescope is infrared, it needs to be cryogenic. And, because of the telescope is infrared, it must operate above the Earth's atmosphere, i.e. in space. JWST is probably the single most complicated mission that humanity has attempted. It is certainly the most difficult optical fabrication and testing challenge of our generation. The JWST 6.5 m diameter primary mirror is nearly a parabola with a conic constant of -0.9967 and radius of curvature at 30K of 15.880 m. The primary mirror is divided into 18 segments with 3 different prescriptions; each with its own off-axis distance and aspheric departure. The radius of curvature for all 18 segments must match to +/- 0.150 mm at 30K. JWST is diffraction limited at 2 micrometers which translates into a transmitted wavefront specification of 156 nm rms. Of that amount, 50 nm rms is allocated to the primary mirror. Each segment is allocated 22 nm rms surface error. At the start of the JWST program, the capability to make such a mirror did not exist. In 1996, NASA began a systematic and comprehensive mirror technology development effort which resulted in JWST. This program resulted in a qualified mirror fabrication process being approved in 2006. Today, all JWST primary mirror segments meet their requirements and are on schedule for a 2018 launch. The next step is system level assembly, integration and test. Ambient tests will be conducted at Goddard Space Flight Center and cryogenic system level testing will be performed in Chamber A at the Johnson Space Center.

Quenching of Particle-Gas Combustible Mixtures Using Electric Particulate Suspension (EPS) and Dispersion Methods

NASA Technical Reports Server (NTRS)

Colver, Gerald M.; Goroshin, Samuel; Lee, John H. S.

2001-01-01

A cooperative study is being carried out between Iowa State University and McGill University. The new study concerns wall and particle quenching effects in particle-gas mixtures. The primary objective is to measure and interpret flame quenching distances, flammability limits, and burning velocities in particulate suspensions. A secondary objective is to measure particle slip velocities and particle velocity distribution as these influence flame propagation. Two suspension techniques will be utilized and compared: (1) electric particle suspension/EPS; and (2) flow dispersion. Microgravity tests will permit testing of larger particles and higher and more uniform dust concentrations than is possible in normal gravity.

DOE Office of Scientific and Technical Information (OSTI.GOV)

McDonald, J R; Murray, R

High winds tend to pick up and transport various objects and debris, which are referred to as wind-borne missiles or tornado missiles, depending on the type of storm. Missiles cause damage by perforating the building envelope or by collapsing structural elements such as walls, columns or frames. The primary objectives of this study are as follows: (1) to provide a basis for wind-borne or tornado missile criteria for the design and evaluation of DOE facilities, and (2) to provide guidelines for the design and evaluation of impact-resistant missile barriers for DOE facilities The first objective is accomplished through a synthesismore » of information from windstorm damage documentation experience and computer simulation of missile trajectories. The second objective is accomplished by reviewing the literature, which describes various missile impact tests, and by conducting a series of impact tests at a Texas Tech University facility to fill in missing information.« less

Use of a primary care database to determine trends in genital chlamydia testing, diagnostic episodes and management in UK general practice, 1990–2004

PubMed Central

Hughes, Gwenda; Williams, Tim; Simms, Ian; Mercer, Catherine; Fenton, Kevin; Cassell, Jackie

2007-01-01

Objective To determine the extent of testing, diagnostic episodes and management of genital Chlamydia trachomatis (CT) infection in UK primary care using a large primary care database. Methods The incidence of CT tests, diagnostic episodes, treatments and referrals was measured for all adult patients in the General Practice Research Database between 1990 and 2004. Results Rates of CT testing in those aged 12–64 years in 2004 increased to 1439/100 000 patient years (py) in women but only 74/100 000 py in men. Testing rates were highest among 20–24‐year‐old women (5.5% tested in 2004), followed by 25–34‐year‐old women (3.7% tested in 2004). 0.5% of registered 16–24‐year‐old women were diagnosed as having CT infection in 2004. Three‐quarters of patients with a recorded diagnosis of CT had had an appropriate prescription issued in 2004, a proportion that increased from 1990 along with a decrease in referrals to genitourinary medicine. In 2004, general practitioners treated 25.0% of all recorded diagnoses of CT in women and 5.1% of those in men. Conclusions Testing for and diagnostic episodes of CT in primary care have increased since 1990. Testing continues disproportionately to target women aged >24 years. Extremely low rates of testing in men, together with high positivity, demonstrate a missed opportunity for diagnosis of CT and contact tracing in general practice. PMID:17360731

Historical trend in the research and development of aircraft

NASA Technical Reports Server (NTRS)

Spearman, M. L.

1981-01-01

Results are presented from a study of aircraft design trends undertaken to determine the relationship between research, development, test and evaluation and aircraft mission capability, requirements and objectives. It is shown that while in some cases a performance objective was the primary research driver, research was the driver in the formulation of objectives in others. Among the topics discussed are: (1) speed considerations such as compressibility, propulsion and test techniques; (2) airframe considerations such as swept, delta, trapezoidal and variable-sweep planforms and mission commonality; (3) research aircraft; (4) the recent impact of computer-aided design; (5) Soviet aircraft development approaches and (6) a comparison of Soviet and U.S. military aircraft design trends. Attention is given to experimental and prototype aircraft programs which, although cancelled, anticipated significant subsequent developments.

NOVEL OXIDANT FOR ELEMENTAL MERCURY CONTROL FROM FLUE GAS

EPA Science Inventory

The primary objective of this study is to develop and test advanced noncarbonaceous solid sorbent materials suitable for removing the elemental form of mercury from power plant emissions. An efficient and cost-effective novel Hg(0) oxidant was evaluated in a lab-scale fixed-bed ...

Guidance of eruption for general practitioners.

PubMed

Ngan, Peter W; Kao, Elizabeth C; Wei, Stephen H

2003-04-01

The principle of early treatment through well-planned extraction of primary teeth followed by removal of permanent teeth has stood the test of time. The objective of this article is to develop some simple guidelines for general dental practitioners to perform 'guidance of eruption' in malocclusion with severe crowding.

SITE TECHNOLOGY CAPSULE: GEOTECH DEVELOPMENT CORPORATION COLD TOP EX-SITU VITRIFICATION TECHNOLOGY

EPA Science Inventory

A SITE technology demonstration was conducted in 1997 to evaluate the potential applicability and effectiveness of the Geotech Cold Top ex-situ vitrification technology on chromium-contaminated soils. The primary objective was to develop test data to evaluate whether the waste a...

Rich in vitamin C or just a convenient snack? Multiple-category reasoning with cross-classified foods.

PubMed

Hayes, Brett K; Kurniawan, Hendy; Newell, Ben R

2011-01-01

Two studies examined multiple category reasoning in property induction with cross-classified foods. Pilot tests identified foods that were more typical of a taxonomic category (e.g., "fruit"; termed 'taxonomic primary') or a script based category (e.g., "snack foods"; termed 'script primary'). They also confirmed that taxonomic categories were perceived as more coherent than script categories. In Experiment 1 participants completed an induction task in which information from multiple categories could be searched and combined to generate a property prediction about a target food. Multiple categories were more often consulted and used in prediction for script primary than for taxonomic primary foods. Experiment 2 replicated this finding across a range of property types but found that multiple category reasoning was reduced in the presence of a concurrent cognitive load. Property type affected which categories were consulted first and how information from multiple categories was weighted. The results show that multiple categories are more likely to be used for property predictions about cross-classified objects when an object is primarily associated with a category that has low coherence.

Developing a Decision Support System for Tobacco Use Counseling Using Primary Care Physicians

PubMed Central

Marcy, Theodore W.; Kaplan, Bonnie; Connolly, Scott W.; Michel, George; Shiffman, Richard N.; Flynn, Brian S.

2009-01-01

Background Clinical decision support systems (CDSS) have the potential to improve adherence to guidelines, but only if they are designed to work in the complex environment of ambulatory clinics as otherwise physicians may not use them. Objective To gain input from primary care physicians in designing a CDSS for smoking cessation to ensure that the design is appropriate to a clinical environment before attempts to test this CDSS in a clinical trial. This approach is of general interest to those designing similar systems. Design and Approach We employed an iterative ethnographic process that used multiple evaluation methods to understand physician preferences and workflow integration. Using results from our prior survey of physicians and clinic managers, we developed a prototype CDSS, validated content and design with an expert panel, and then subjected it to usability testing by physicians, followed by iterative design changes based on their feedback. We then performed clinical testing with individual patients, and conducted field tests of the CDSS in two primary care clinics during which four physicians used it for routine patient visits. Results The CDSS prototype was substantially modified through these cycles of usability and clinical testing, including removing a potentially fatal design flaw. During field tests in primary care clinics, physicians incorporated the final CDSS prototype into their workflow, and used it to assist in smoking cessation interventions up to eight times daily. Conclusions A multi-method evaluation process utilizing primary care physicians proved useful for developing a CDSS that was acceptable to physicians and patients, and feasible to use in their clinical environment. PMID:18713526

The Sensor Test for Orion RelNav Risk Mitigation (STORRM) Development Test Objective

NASA Technical Reports Server (NTRS)

Christian, John A.; Hinkel, Heather; D'Souza, Christopher N.; Maguire, Sean; Patangan, Mogi

2011-01-01

The Sensor Test for Orion Relative-Navigation Risk Mitigation (STORRM) Development Test Objective (DTO) flew aboard the Space Shuttle Endeavour on STS-134 in May- June 2011, and was designed to characterize the performance of the flash LIDAR and docking camera being developed for the Orion Multi-Purpose Crew Vehicle. The flash LIDAR, called the Vision Navigation Sensor (VNS), will be the primary navigation instrument used by the Orion vehicle during rendezvous, proximity operations, and docking. The DC will be used by the Orion crew for piloting cues during docking. This paper provides an overview of the STORRM test objectives and the concept of operations. It continues with a description of STORRM's major hardware components, which include the VNS, docking camera, and supporting avionics. Next, an overview of crew and analyst training activities will describe how the STORRM team prepared for flight. Then an overview of in-flight data collection and analysis is presented. Key findings and results from this project are summarized. Finally, the paper concludes with lessons learned from the STORRM DTO.

FINAL REPORT INTEGRATED DM1200 MELTER TESTING USING AZ 102 AND C 106/AY-102 HLW SIMULANTS: HLW SIMULANT VERIFICATION VSL-05R5800-1 REV 0 6/27/05

DOE Office of Scientific and Technical Information (OSTI.GOV)

KRUGER AA; MATLACK KS; GONG W

2011-12-29

The principal objectives of the DM1200 melter tests were to determine the effects of feed rheology, feed solid content, and bubbler configuration on glass production rate and off-gas system performance while processing the HLW AZ-101 and C-106/AY-102 feed compositions; characterize melter off-gas emissions; characterize the performance of the prototypical off-gas system components, as well as their integrated performance; characterize the feed, glass product, and off-gas effluents; and perform pre- and post test inspections of system components. The specific objectives (including test success criteria) of this testing, along with how each objective was met, are outlined in a table. The datamore » provided in this Final Report address the impacts of HLW melter feed rheology on melter throughput and validation of the simulated HLW melter feeds. The primary purpose of this testing is to further validate/verify the HLW melter simulants that have been used for previous melter testing and to support their continued use in developing melter and off-gas related processing information for the Project. The primary simulant property in question is rheology. Simulants and melter feeds used in all previous melter tests were produced by direct addition of chemicals; these feed tend to be less viscous than rheological the upper-bound feeds made from actual wastes. Data provided here compare melter processing for the melter feed used in all previous DM100 and DM1200 tests (nominal melter feed) with feed adjusted by the feed vendor (NOAH Technologies) to be more viscous, thereby simulating more closely the upperbounding feed produced from actual waste. This report provides results of tests that are described in the Test Plan for this work. The Test Plan is responsive to one of several test objectives covered in the WTP Test Specification for this work; consequently, only part of the scope described in the Test Specification was addressed in this particular Test Plan. For the purpose of comparison, the tests reported here were performed with AZ-102 and C-106/AY-102 HLW simulants and glass compositions that are essentially the same as those used for recent DM1200 tests. One exception was the use of an alternate, higher-waste-loading C-106/AY-102 glass composition that was used in previous DM100 tests to further evaluate the performance of the optimized bubbler configuration.« less

Factors influencing and modifying the decision to pursue genetic testing for skin cancer risk.

PubMed

Fogel, Alexander L; Jaju, Prajakta D; Li, Shufeng; Halpern-Felsher, Bonnie; Tang, Jean Y; Sarin, Kavita Y

2017-05-01

Across cancers, the decision to pursue genetic testing is influenced more by subjective than objective factors. However, skin cancer, which is more prevalent, visual, and multifactorial than many other malignancies, may offer different motivations for pursuing such testing. The primary objective was to determine factors influencing the decision to receive genetic testing for skin cancer risk. A secondary objective was to assess the impact of priming with health questions on the decision to receive testing. We distributed anonymous online surveys through ResearchMatch.org to assess participant health, demographics, motivations, and interest in pursuing genetic testing for skin cancer risk. Two surveys with identical questions but different question ordering were used to assess the secondary objective. We received 3783 responses (64% response rate), and 85.8% desired testing. Subjective factors, including curiosity, perceptions of skin cancer, and anxiety, were the most statistically significant determinants of the decision to pursue testing (P < .001), followed by history of sun exposure (odds ratio 1.85, P < .01) and history of skin cancer (odds ratio 0.5, P = .01). Age and family history of skin cancer did not influence this decision. Participants increasingly chose testing if first queried about health behaviors (P < .0001). The decision to pursue hypothetical testing may differ from in-clinic decision-making. Self-selected, online participants may differ from the general population. Surveys may be subject to response bias. The decision to pursue genetic testing for skin cancer is primarily determined by subjective factors, such as anxiety and curiosity. Health factors, including skin cancer history, also influenced decision-making. Priming with consideration of objective health factors can increase the desire to pursue testing. Copyright © 2016 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

24 CFR 570.901 - Review for compliance with the primary and national objectives and other program requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... primary and national objectives and other program requirements. 570.901 Section 570.901 Housing and Urban... primary and national objectives and other program requirements. HUD will review each entitlement, Insular...)(3) that, consistent with the primary objective of the Act, not less than 70 percent of the aggregate...

Aircraft and Ground Vehicle Winter Runway Friction Assessment

NASA Technical Reports Server (NTRS)

Yager, Thomas J.

1999-01-01

Some background information is given together with the scope and objectives of a 5-year, Joint Winter Runway Friction Measurement Program between the National Aeronautics & Space Administration (NASA), Transport Canada (TC), and the Federal Aviation Administration (FAA). The primary objective of this effort is to perform instrumented aircraft and ground vehicle tests aimed at identifying a common number that all the different ground vehicle devices would report. This number, denoted the International Runway Friction Index (IRFI), will be related to all types of aircraft stopping performance. The range of test equipment, the test sites, test results and accomplishments, the extent of the substantial friction database compiled, and future test plans will be described. Several related studies have also been implemented including the effects of contaminant type on aircraft impingement drag, and the effectiveness of various runway and aircraft de-icing chemical types, and application rates.

Central Atlantic regional ecological test site

NASA Technical Reports Server (NTRS)

Alexander, R. H.

1972-01-01

The work of the Central Atlantic Regional Ecological Test Site (CARETS) project is discussed. The primary aim of CARETS is to test the hypothesis that data from ERTS-A can be made an integral part of a regional land resources information system, encompassing both inventory of the resource base and monitoring of changes, along with their effects on the quality of the environment. Another objective of the project is to determine scaling factors for developing land use information and regional analysis for regions of any given size.

Configuration management issues and objectives for a real-time research flight test support facility

NASA Technical Reports Server (NTRS)

Yergensen, Stephen; Rhea, Donald C.

1988-01-01

An account is given of configuration management activities for the Western Aeronautical Test Range (WATR) at NASA-Ames, whose primary function is the conduct of aeronautical research flight testing through real-time processing and display, tracking, and communications systems. The processing of WATR configuration change requests for specific research flight test projects must be conducted in such a way as to refrain from compromising the reliability of WATR support to all project users. Configuration management's scope ranges from mission planning to operations monitoring and performance trend analysis.

Galileo attitude and articulation control subsystem closed loop testing

NASA Technical Reports Server (NTRS)

Lembeck, M. F.; Pignatano, N. D.

1983-01-01

In order to ensure the reliable operation of the Attitude and Articulation Control Subsystem (AACS) which will guide the Galileo spacecraft on its two and one-half year journey to Jupiter, the AACS is being rigorously tested. The primary objectives of the test program are the verification of the AACS's form, fit, and function, especially with regard to subsystem external interfaces and the functional operation of the flight software. Attention is presently given to the Galileo Closed Loop Test System, which simulates the dynamic and 'visual' flight environment for AACS components in the laboratory.

Opt-out provider-initiated HIV testing and counselling in primary care outpatient clinics in Zambia

PubMed Central

Chipukuma, Julien M; Chiko, Matimba M; Wamulume, Chibesa S; Bolton-Moore, Carolyn; Reid, Stewart E

2011-01-01

Abstract Objective To increase case-finding of infection with human immunodeficiency virus (HIV) in Zambia and their referral to HIV care and treatment by supplementing existing client-initiated voluntary counselling and testing (VCT), the dominant mode of HIV testing in the country. Methods Lay counsellors offered provider-initiated HIV testing and counselling (PITC) to all outpatients who attended primary clinics and did not know their HIV serostatus. Data on counselling and testing were collected in registers. Outcomes of interest included HIV testing coverage, the acceptability of testing, the proportion testing HIV-positive (HIV+), the proportion enrolling in HIV care and treatment and the time between testing and enrolment. Findings After the addition of PITC to VCT, the number tested for HIV infection in the nine clinics was twice the number undergoing VCT alone. Over 30 months, 44 420 patients were counselled under PITC and 31 197 patients, 44% of them men, accepted testing. Of those tested, 21% (6572) were HIV+; 38% of these HIV+ patients (2515) enrolled in HIV care and treatment. The median time between testing and enrolment was 6 days. The acceptability of testing rose over time. Conclusion The introduction of routine PITC using lay counsellors into health-care clinics in Lusaka, Zambia, dramatically increased the uptake and acceptability of HIV testing. Moreover, PITC was incorporated rapidly into primary care outpatient departments. Maximizing the number of patients who proceed to HIV care and treatment remains a challenge and warrants further research. PMID:21556300

Improving diabetes care among patients overdue for recommended testing: a randomized controlled trial of automated telephone outreach.

PubMed

Simon, Steven R; Trinacty, Connie Mah; Soumerai, Stephen B; Piette, John D; Meigs, James B; Shi, Ping; Ensroth, Arthur; Ross-Degnan, Dennis

2010-07-01

The study's objective was to assess the effects of automated telephone outreach with speech recognition (ATO-SR) on diabetes-related testing. We identified 1,200 health plan members who were overdue for diabetes-related testing and randomly allocated 600 to ATO-SR and 600 to usual care (no intervention). The intervention included three interactive calls encouraging recommended testing. The primary outcome was retinopathy testing, since this was the health plan's principal goal. Tests for glycemia, hyperlipidemia, and nephropathy were secondary outcomes. In total, 232 participants (39%) verbally responded to the calls. There was no difference between the intervention and the usual care groups in the primary outcome (adjusted hazard ratio 0.93 [95% CI 0.71-1.22]) and no effect of the intervention on any of the secondary outcomes. Fewer than 40% of the patients randomized to ATO-SR interacted verbally with the system. The intervention had no effect on the study's outcomes.

Assessment of the potential of Allium sativum oil as a new medicament for non-vital pulpotomy of primary teeth.

PubMed

Mohammad, Shukry Gamal; Baroudi, Kusai

2015-01-01

The objective of this study was to compare the clinical and radiographic effects of Allium sativum oil and formocresol in nonvital pulpotomy in primary teeth. Twenty children ranging in age from 4 to 8 years were included in the study. In every one of those children, pulpotomy was indicated for the primary molars. Pulpotomy procedure was performed and the radicular pulp tissue of one molar was capped with A. sativum oil in a cotton pellet while the other molar was capped with formocresol. The teeth were evaluated clinically and radiographically before and after 6 months using standard clinical and radiographic criteria. Statistically, these results revealed significant difference between the radiographic findings of nonvital pulpotomy in primary molars with the two medicaments. Statistical analysis was performed using independent t-test and paired t-test at the significance level of α = 0.05. A. sativum oil has potent antibacterial properties that enable it to combat intracanal microbes in the infected pulp of primary molars. Better results were obtained when A. sativum oil was used. A. sativum oil had more powerful effects than formocresol on the infected pulp of primary nonvital molars.

Creating a Test Validated Structural Dynamic Finite Element Model of the Multi-Utility Technology Test Bed Aircraft

NASA Technical Reports Server (NTRS)

Pak, Chan-Gi; Truong, Samson S.

2014-01-01

Small modeling errors in the finite element model will eventually induce errors in the structural flexibility and mass, thus propagating into unpredictable errors in the unsteady aerodynamics and the control law design. One of the primary objectives of Multi Utility Technology Test Bed, X-56A, aircraft is the flight demonstration of active flutter suppression, and therefore in this study, the identification of the primary and secondary modes for the structural model tuning based on the flutter analysis of X-56A. The ground vibration test validated structural dynamic finite element model of the X-56A is created in this study. The structural dynamic finite element model of the X-56A is improved using a model tuning tool. In this study, two different weight configurations of the X-56A have been improved in a single optimization run.

Effects of aggregate gradation, aggregate type, and SBS polymer-modified binder on Florida HMAC fracture energy properties : final report, March 2009.

DOT National Transportation Integrated Search

2009-03-01

"The primary objective of this research study was to evaluate the fracture mechanics properties of HMA concrete for Superpave mixtures. An experimental program was performed on asphalt mixtures with various types of materials. The laboratory testing ...

Trauma, Binge Eating, and the "Strong Black Woman"

ERIC Educational Resources Information Center

Harrington, Ellen F.; Crowther, Janis H.; Shipherd, Jillian C.

2010-01-01

Objective: The primary goal of this study was to test a culturally specific model of binge eating in African American female trauma survivors, investigating potential mechanisms through which trauma exposure and distress were related to binge eating symptomatology. Method: Participants were 179 African American female trauma survivors who…

A methodology for determining economic impacts of raised medians : data analysis on additional case studies

DOT National Transportation Integrated Search

1999-10-01

The objective of this four-year research effort is to develop and test a methodology to estimate the economic impacts of median design. This report summarizes the activities performed in the third year of this project. The primary task in the third y...

Teledynamic Evaluation of Oropharyngeal Swallowing

ERIC Educational Resources Information Center

Malandraki, Georgia A.; McCullough, Gary; He, Xuming; McWeeny, Elizabeth; Perlman, Adrienne L.

2011-01-01

Purpose: The objective of the present investigation was to test the feasibility and clinical utility of a real-time Internet-based protocol for remote, telefluoroscopic evaluation of oropharyngeal swallowing. Method: In this prospective cohort study, the authors evaluated 32 patients with a primary diagnosis of stroke or head/neck cancer. All…

[Coping and subjective burden in primary caregivers of dependent elderly relatives in Andalusia, Spain].

PubMed

Pérez-Cruz, Margarita; Muñoz-Martínez, M Ángeles; Parra-Anguita, Laura; Del-Pino-Casado, Rafael

To analyse the relationship between the type of coping and subjective burden in caregivers of dependent elderly relatives in Andalusia (Spain). Cross-sectional study. Primary Health Care (autonomous community of Andalusia, Spain). A convenience sample of 198 primary caregivers of dependent elderly relatives. Coping (Brief COPE), subjective burden (caregiver stress index), objective burden (functional capacity [Barthel Index], cognitive impairment [Pfeiffer Test], behavioural problems of the care recipient [Neuropsychiatric Inventory], and caregivers' dedication to caring), gender and kinship. Most caregivers were women (89.4%), daughters of the care recipient (57.1%), and shared home with him/her (69.7%). On controlling for objective burden, gender and kinship, it was found that subjective burden was positively associated with dysfunctional coping (β=0.28; P<.001) and negatively with emotion-focused coping (β=-0.25; P=.001), while no association was found with problem-focused coping. Dysfunctional coping may be a risk factor for subjective burden, and emotion-focused coping may be a protective factor for that subjective burden regardless of the objective burden, and gender and kinship of the caregivers. Copyright © 2016 Elsevier España, S.L.U. All rights reserved.

Wear of two pit and fissure sealants in contact with primary teeth

PubMed Central

Galo, Rodrigo; Contente, Marta Maria Martins Giamatei; Borsatto, Maria Cristina

2014-01-01

Objectives: Wear simulations may provide an indication of the clinical performance of pit-and-fissure sealants when associated with primary teeth as counterbody, restricting the involved variables. The aim of this study was to evaluate wear of dental materials used as pit-and-fissure sealants in contact with primary teeth. Materials and Methods: A resinous sealant (Fluroshield®) and a resin-modified glass ionomer cement (Vitremer®) were selected in a post-plate design, using as counterbody primary tooth pins (4 × 4 × 2 mm) at 3 and 10 N vertical load, 1 Hz frequency, 900 wear cycles in artificial saliva (n = 15). Attrition coefficient values were obtained and the material and primary tooth volumes were analyzed. Data were analyzed statistically by ANOVA and Duncan's test (P < 0.05). Results: Fluroshield® presented the highest attrition coefficient values for the 3 N but these values decreased significantly for the 10 N load. The means for volume loss (3 mm) of the different samples after the wear test were not statistically different for the materials. The volume loss values for the primary teeth were statistically different and there was an increase in volume loss with the increase of the load applied in the wear tests. Conclusions: Differences were also observed with regard to the surface deformation characteristics. The wear rates of primary tooth enamel vary according to the type of material and the load applied during mastication. PMID:24966777

Accuracy of a smartphone to test laryngoscope's light and an audit to our laryngoscopes using an ISO standard.

PubMed

Machado, Diogo Alcino de Abreu Ribeiro Carvalho; Esteves, Dina da Assunção Azevedo; Branca, Pedro Manuel Araújo de Sousa

Laryngoscope is a key tool in anesthetic practice. Direct laryngoscopy is a crucial moment and inadequate laryngoscope's light can lead to catastrophic consequences. From our experience laryngoscope's light is assessed in a subjective manner and we believe a more precise evaluation should be used. Our objective is to compare the accuracy of a smartphone compared to a lux meter. Secondly we audited our Operating Room laryngoscopes. We designed a pragmatic study, using as primary outcome the accuracy of a smartphone compared to the lux meter. Further we audited with both the lux meter and the smartphone all laryngoscopes and blades ready to use in our Operating Rooms, using the International Standard form the International Organization for Standardization. For primary outcome we found no significant difference between devices. Our audit showed that only 2 in 48 laryngoscopes complied with the ISO norm. When comparing the measurements between the lux meter and the smartphone we found no significant difference. Ideally every laryngoscope should perform as required. We believe all laryngoscopes should have a practical but reliable and objective test prior to its utilization. Our results suggest the smartphone was accurate enough to be used as a lux meter to test laryngoscope's light. Audit results showing only 4% comply with the ISO standard are consistent with other studies. The tested smartphone has enough accuracy to perform light measurement in laryngoscopes. We believe this is a step further to perform an objective routine check to laryngoscope's light. Copyright © 2016. Published by Elsevier Editora Ltda.

Validation of the Chinese Handwriting Analysis System (CHAS) for primary school students in Hong Kong.

PubMed

Li-Tsang, Cecilia W P; Wong, Agnes S K; Leung, Howard W H; Cheng, Joyce S; Chiu, Billy H W; Tse, Linda F L; Chung, Raymond C K

2013-09-01

There are more children diagnosed with specific learning difficulties in recent years as people are more aware of these conditions. Diagnostic tool has been validated to screen out this condition from the population (SpLD test for Hong Kong children). However, for specific assessment on handwriting problem, there seems a lack of standardized and objective evaluation tool to look into the problems. The objective of this study was to validate the Chinese Handwriting Analysis System (CHAS), which is designed to measure both the process and production of handwriting. The construct validity, convergent validity, internal consistency and test-retest reliability of CHAS was analyzed using the data from 734 grade 1-6 students from 6 primary schools in Hong Kong. Principal Component Analysis revealed that measurements of CHAS loaded into 4 components which accounted for 77.73% of the variance. The correlation between the handwriting accuracy obtained from HAS and eyeballing was r=.73. Cronbach's alpha of all measurement items was .65. Except SD of writing time per character, all the measurement items regarding handwriting speed, handwriting accuracy and pen pressure showed good to excellent test-retest reliability (r=.72-.96), while measurement on the numbers of characters which exceeded grid showed moderate reliability (r=.48). Although there are still ergonomic, biomechanical or unspecified aspects which may not be determined by the system, the CHAS can definitely assist therapists in identifying primary school students with handwriting problems and implement interventions accordingly. Copyright © 2013 Elsevier Ltd. All rights reserved.

The Value of Losartan Suppression Test in the Confirmatory Diagnosis of Primary Aldosteronism in Patients Over 50 Years Old

PubMed Central

Kuo, Chin-Chi; Balakrishnan, Poojitha; Hsein, Yenh-Chen; Wu, Vin-Cent; Chueh, Shih-Chieh Jeff; Chen, Yung-Ming; Wu, Kwan-Dun; Wang, Ming-Jiuh

2013-01-01

Objective The diagnosis of primary aldosteronism (PA) among the older-aged population has posed a crucial challenge. Among patients over 50 years old, this trial assessed comparability of the performance of two PA diagnostic tests: losartan and captoril suppression tests. Methods A post-hoc subgroup analysis from a prospective cohort was conducted by TAIPAI (Taiwan Primary Aldosteornism Investigation) group between July 2003 and July 2006. Of the 160 patients in the cohort, 60 patients over 50 years received captopril and losartan tests to confirm PA. Results Among the 60 patients over 50 years old, 31 patients had PA confirmed by standardized protocol. The area under the receiver-operating characteristic (ROC) curve of the post-captopril aldosterone was significantly less than that of the post-losartan plasma aldosterone concentration (0.87 vs. 0.94, p = 0.02). Using ARR>35 with PAC>10 ng/dL, the specificity was 82.76% vs. 93.1% and the sensitivity was 77.42% vs. 87.10% for the captopril and losartan tests, respectively. The equivalence between the two tests were confirmed by exact McNemar test (p= 1.0). Conclusion The losartan test showed comparable accuracy to confirm PA. Verification of this “elderly-friendly” confirmatory test will be the first step to prepare the specific diagnostic model of PA for older-aged population. PMID:25031295

A study of the effectiveness of the primary education improvement program (science) in selected schools of Northern Nigeria

NASA Astrophysics Data System (ADS)

Brown, Desmond P.; Reed, Jack A.

The Primary Education Improvement Program (Science) developed in Nigeria from 1970-1980 adopted a process approach to the teaching of science for children in Classes One and Two of primary school. In that insufficient formative data were available a study was organized to evaluate the attainment of the program's major objectives in terms of the children's ability to practice process skills. The study also attempted to measure children's interest, active participation and understanding of the lessons, as well as the availability of materials and ease of preparing and teaching the lessons for the teachers. Data were collected by means of teacher opinionnaires and a children's test to measure the attainment of process skills. The teachers who completed the opinionnaires rated the program as successful in terms of all the measured criteria. Children in the experimental and control groups were tested and their performances were compared. The results indicated that there were some significant differences in total test scores in favor of the experimental group after one year of primary school but none after two years. The program, though highly rated by teachers, did not produce the intended changes in children's behavior.

Calculation of natural convection test at Phenix using the NETFLOW++ code

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mochizuki, H.; Kikuchi, N.; Li, S.

2012-07-01

The present paper describes modeling and analyses of a natural convection of the pool-type fast breeder reactor Phenix. The natural convection test was carried out as one of the End of Life Tests of the Phenix. Objective of the present study is to assess the applicability of the NETFLOW++ code which has been verified thus far using various water facilities and validated using the plant data of the loop-type FBR 'Monju' and the loop-type experimental fast reactor 'Joyo'. The Phenix primary heat transport system is modeled based on the benchmark documents available from IAEA. The calculational model consists of onlymore » the primary heat transport system with boundary conditions on the secondary-side of IHX. The coolant temperature at the primary pump inlet, the primary coolant temperature at the IHX inlet and outlet, the secondary coolant temperatures and other parameters are calculated by the code where the heat transfer between the hot and cold pools is explicitly taken into account. A model including the secondary and tertiary systems was prepared, and the calculated results also agree well with the measured data in general. (authors)« less

Request for HIV serology in primary care: A survey of medical and nursing professionals.

PubMed

Pichiule-Castañeda, Myrian; Domínguez-Berjón, M Felicitas; Esteban-Vasallo, María D; García-Riolobos, Carmen; Álvarez-Castillo, M Carmen; Astray-Mochales, Jenaro

2018-01-15

In the Community of Madrid there is 42.7% late HIV diagnosis. Primary care is the gateway to the health system and the frequency of serological tests requested by these professionals is unknown. The objectives were to establish the frequency of requests for HIV serology by medical and nursing primary care professionals in the Community of Madrid and the factors associated with these requests. An 'on-line' survey was conducted, asking professionals who participated in the evaluation study of strategies to promote early diagnosis of HIV in primary care in the Community of Madrid (ESTVIH) about the number of HIV-serology tests requested in the last 12 months. The association between HIV-serology requesting and the sociodemographic and clinical practice characteristics of the professionals was quantified using adjusted odds ratios (aOR) according to logistic regression. 264 surveys (59.5% physicians). Eighty-two point two percent of medical and 18.7% of nursing professionals reported requesting at least one HIV-serology in the last 12 months (median: 15 and 2 HIV-serology request, respectively). The doctors associated the request with: being male (aOR: 2.95; 95% CI: 0.82-10.56), being trained in pre-post HIV test counselling (aOR: 2.42; 95% CI: 0.84-6.93) and the nurses with: age (<50 years; aOR: 2.75; 95% CI: 0.97-7.75), and number of years working in primary care (>13 years; aOR: 3.02; 95% CI: 1.07-8.52). It is necessary to promote HIV testing and training in pre-post HIV test counselling for medical and nursing professionals in primary care centres. Copyright © 2017 Elsevier España, S.L.U. All rights reserved.

An assessment of primary care attributes from the perspective of female healthcare users1

PubMed Central

Lima, Eliane de Fátima Almeida; Sousa, Ana Inês; Primo, Cândida Caniçali; Leite, Francielie Marabotti Costa; Lima, Rita de Cassia Duarte; Maciel, Ethel Leonor Nóia

2015-01-01

OBJECTIVE: this study sought to assess the quality of the Family Health Strategy (FHS) and investigated the association between primary care attributes (PCAs) and the sociodemographic characteristics of users. METHOD: a total of 215 female FHS users were interviewed for this descriptive and cross-sectional study. The Primary Care Assessment Tool (PCATool), Adult Edition was used, and the results were analyzed using Fisher's exact tests, Pearson's chi-square tests and logistic regressions. RESULTS: the lowest average score corresponded to the dimension "accessibility" (1.80), and the highest score corresponded to "access" (8.76). The results corresponding to the attributes "longitudinality", "coordination", "comprehensiveness", and "orientation" were not significant. No association was found between the participants' sociodemographic characteristics and the essential, derivative, and general attributes (p>0.05). CONCLUSION: several attributes must be improved across all the investigated services from the perspective of female FHS users. PMID:26155006

The interaction of feature and space based orienting within the attention set.

PubMed

Lim, Ahnate; Sinnett, Scott

2014-01-01

The processing of sensory information relies on interacting mechanisms of sustained attention and attentional capture, both of which operate in space and on object features. While evidence indicates that exogenous attentional capture, a mechanism previously understood to be automatic, can be eliminated while concurrently performing a demanding task, we reframe this phenomenon within the theoretical framework of the "attention set" (Most et al., 2005). Consequently, the specific prediction that cuing effects should reappear when feature dimensions of the cue overlap with those in the attention set (i.e., elements of the demanding task) was empirically tested and confirmed using a dual-task paradigm involving both sustained attention and attentional capture, adapted from Santangelo et al. (2007). Participants were required to either detect a centrally presented target presented in a stream of distractors (the primary task), or respond to a spatially cued target (the secondary task). Importantly, the spatial cue could either share features with the target in the centrally presented primary task, or not share any features. Overall, the findings supported the attention set hypothesis showing that a spatial cuing effect was only observed when the peripheral cue shared a feature with objects that were already in the attention set (i.e., the primary task). However, this finding was accompanied by differential attentional orienting dependent on the different types of objects within the attention set, with feature-based orienting occurring for target-related objects, and additional spatial-based orienting for distractor-related objects.

The interaction of feature and space based orienting within the attention set

PubMed Central

Lim, Ahnate; Sinnett, Scott

2014-01-01

The processing of sensory information relies on interacting mechanisms of sustained attention and attentional capture, both of which operate in space and on object features. While evidence indicates that exogenous attentional capture, a mechanism previously understood to be automatic, can be eliminated while concurrently performing a demanding task, we reframe this phenomenon within the theoretical framework of the “attention set” (Most et al., 2005). Consequently, the specific prediction that cuing effects should reappear when feature dimensions of the cue overlap with those in the attention set (i.e., elements of the demanding task) was empirically tested and confirmed using a dual-task paradigm involving both sustained attention and attentional capture, adapted from Santangelo et al. (2007). Participants were required to either detect a centrally presented target presented in a stream of distractors (the primary task), or respond to a spatially cued target (the secondary task). Importantly, the spatial cue could either share features with the target in the centrally presented primary task, or not share any features. Overall, the findings supported the attention set hypothesis showing that a spatial cuing effect was only observed when the peripheral cue shared a feature with objects that were already in the attention set (i.e., the primary task). However, this finding was accompanied by differential attentional orienting dependent on the different types of objects within the attention set, with feature-based orienting occurring for target-related objects, and additional spatial-based orienting for distractor-related objects. PMID:24523682

Comparison of measured and modeled radiation, heat and water vapor fluxes: FIFE pilot study

NASA Technical Reports Server (NTRS)

Blad, Blaine L.; Verma, Shashi B.; Hubbard, Kenneth G.; Starks, Patrick; Hays, Cynthia; Norman, John M.; Waltershea, Elizabeth

1988-01-01

The primary objectives of the 1985 study were to test the feasibility of using radio frequency receivers to collect data from automated weather stations and to evaluate the use of the data collected by the automated weather stations for modeling the fluxes of latent heat, sensible heat, and radiation over wheat. The model Cupid was used to calculate these fluxes which were compared with fluxes of these entities measured using micrometeorological techniques. The primary objectives of the 1986 study were to measure and model reflected and emitted radiation streams at a few locations within the First International Satellite Land-Surface Climatology Project Field Experiment (FIFE) site and to compare modeled and measured latent heat and sensible heat fluxes from the prairie vegetation.

STA-2A NDT testing

NASA Technical Reports Server (NTRS)

Lewis, T. J.

1987-01-01

The nondestructive testing (NDT) on the Space Shuttle Solid Rocket Booster (SRB) filament wound case (FWC) short stact structural test articles 2 (STA-2A) during test of phases 1B-9C is described. The primary objective of this testing was to verify the structural integrity of the SRB-FWC for critical design loads. Another objective was to quantify the effect of load distributions in the aft skirt. The NDT objectives were to determine the acoustic emission characteristics of the FWC-SRB and to identify possible design deficiencies or defect growth. The results from the posttest inspection of the samples shows the depth measurements taken were accurate until exceeding .260 inches thickness. The data then show that pulse echo measurements exceeded actual part thickness by 10 to 14 percent. The mapping of forward boundaries of delaminations proved to be within the tolerance of the equipment. Using the ZIP probe, the maximum difference between the pulse echo boundary and the visual boundary was expected to be no greater than one half the diameter of the probe. The NDT performance on STA-2A shows how NDT can be used to assist design engineering in evaluating the structural integrity of composite test articles.

Model for the evaluation of drug-dispensing services in primary health care

PubMed Central

Sartor, Vanessa de Bona; de Freitas, Sergio Fernando Torres

2014-01-01

OBJECTIVE To develop a model for evaluating the efficacy of drug-dispensing service in primary health care. METHODS An efficacy criterion was adopted to determine the level of achievement of the service objectives. The evaluation model was developed on the basis of a literature search and discussions with experts. The applicability test of the model was conducted in 15 primary health care units in the city of Florianópolis, state of Santa Catarina, in 2010, and data were recorded in structured and pretested questionnaires. RESULTS The model developed was evaluated using five dimensions of analysis for analysis. The model was suitable for evaluating service efficacy and helped to identify the critical points of each service dimension. CONCLUSIONS Adaptations to the data collection technique may be required to adjust for the reality and needs of each situation. The evaluation of the drug-dispensing service should promote adequate access to medications supplied through the public health system. PMID:25372174

Prevalence of Primary Sjögren's Syndrome in a US Population-Based Cohort.

PubMed

Maciel, Gabriel; Crowson, Cynthia S; Matteson, Eric L; Cornec, Divi

2017-10-01

To report the point prevalence of primary Sjögren's syndrome (SS) in the first US population-based study. Cases of all potential primary SS patients living in Olmsted County, Minnesota, on January 1, 2015, were retrieved using Rochester Epidemiology Project resources, and ascertained by manual medical records review. Primary SS cases were defined according to physician diagnosis. The use of diagnostic tests was assessed and the performance of classification criteria was evaluated. The number of prevalent cases in 2015 was also projected based on 1976-2005 incidence data from the same source population. A total of 106 patients with primary SS were included in the study: 86% were female, with a mean ± SD age of 64.6 ± 15.2 years, and a mean ± SD disease duration of 10.5 ± 8.4 years. A majority were anti-SSA positive (75%) and/or anti-SSB positive (58%), but only 22% met American-European Consensus Group or American College of Rheumatology criteria, because the other tests required for disease classification (ocular dryness objective assessment, salivary gland functional or morphologic tests, or salivary gland biopsy) were rarely performed in clinical practice. According to the physician diagnosis, the age- and sex-adjusted prevalence of primary SS was 10.3 per 10,000 inhabitants, but according to classification criteria, this prevalence was only 2.2 per 10,000. The analysis based on previous incidence data projected a similar 2015 prevalence rate of 11.0 per 10,000. The prevalence of primary SS in this geographically well-defined population was estimated to be between 2 and 10 per 10,000 inhabitants. Physicians rarely used tests included in the classification criteria to diagnose the disease in this community setting. © 2016, American College of Rheumatology.

[Component and System Level of the FASTRAC Engine

NASA Technical Reports Server (NTRS)

1999-01-01

The primary activities of Lee & Associates during the period 7/20/99 to 12/31/99 as specified in the referenced Purchase Order has been in direct support of the Advanced Space Technology Program OfFice's Core Propulsion Project. An independent review to assess the program readiness to conduct component and system level testing of the FASTRAC Engine and to proceed into Fabrication has been provided. This was accomplished through the identification of program weaknesses and potential failure areas and where applicable recommended solutions were suggested to the Program Office that would mitigate technical and program risk. The approach taken to satisfy the objectives has been for the contractor to provide a team of experts with relevant experience from past programs and a strong background of experience in the fields critical to the success of the program. The team participated in Test Planning, Test Readiness Reviews for system testing at Stennis Space Center, Anomaly Resolution Reviews, an Operations Audit, and data analysis. This approach worked well in satisfying the objectives and providing the Project Office with valuable information in real time and through monthly reports. During the month of December 1999 the primary effort involved the participation in anomaly resolution and the detailed review of the data from the final H3 and H4 test series performed on the FASTRAC engine in the b-2 Horizontal Test Facility at Stennis. The more significant findings and recommendations from this review are presented in this report.

Characterization of interdigitated electrode piezoelectric fiber composites under high electrical and mechanical loading

NASA Astrophysics Data System (ADS)

Rodgers, John P.; Bent, Aaron A.; Hagood, Nesbitt W.

1996-05-01

The primary objective of this work is to develop a standard methodology for characterizing structural actuation systems intended for operation in high electrical and mechanical loading environments. The designed set of tests evaluates the performance of the active materials system under realistic operating conditions. The tests are also used to characterize piezoelectric fiber composites which have been developed as an alternative to monolithic piezoceramic wafers for structural actuation applications. The performance of this actuator system has been improved using an interdigitated electrode pattern, which orients the primary component of the electric field into the plane of the structure, enabling the use of the primary piezoelectric effect along the active fibers. One possible application of this technology is in the integral twist actuation of helicopter rotor blades for higher harmonic control. This application requires actuators which can withstand the harsh rotor blade operating environment. This includes large numbers of electrical and mechanical cycles with considerable centripetal and bending loads. The characterization tests include standard active material tests as well as application-driven tests which evaluate the performance of the actuators during simulated operation. Test results for several actuator configurations are provided, including S2 glass- reinforced and E-glass laminated actuators. The study concludes that the interdigitated electrode piezoelectric fiber composite actuator has great potential for high loading applications.

A MULTIPLE TESTING OF THE ABC METHOD AND THE DEVELOPMENT OF A SECOND GENERATION MODEL. PART I, PRELIMINARY DISCUSSIONS OF METHODOLOGY. SUPPLEMENT, COMPUTER PROGRAMS OF THE HDL INFORMATION SYSTEMS.

ERIC Educational Resources Information Center

ALTMANN, BERTHOLD; BROWN, WILLIAM G.

THE FIRST-GENERATION APPROACH BY CONCEPT (ABC) STORAGE AND RETRIEVAL METHOD, A METHOD WHICH UTILIZES AS A SUBJECT APPROACH APPROPRIATE STANDARDIZED ENGLISH-LANGUAGE STATEMENTS PROCESSED AND PRINTED IN A PERMUTED INDEX FORMAT, UNDERWENT A PERFORMANCE TEST, THE PRIMARY OBJECTIVE OF WHICH WAS TO SPOT DEFICIENCIES AND TO DEVELOP A SECOND-GENERATION…

Improving Science Process Skills for Primary School Students Through 5E Instructional Model-Based Learning

NASA Astrophysics Data System (ADS)

Choirunnisa, N. L.; Prabowo, P.; Suryanti, S.

2018-01-01

The main objective of this study is to describe the effectiveness of 5E instructional model-based learning to improve primary school students’ science process skills. The science process skills is important for students as it is the foundation for enhancing the mastery of concepts and thinking skills needed in the 21st century. The design of this study was experimental involving one group pre-test and post-test design. The result of this study shows that (1) the implementation of learning in both of classes, IVA and IVB, show that the percentage of learning implementation increased which indicates a better quality of learning and (2) the percentage of students’ science process skills test results on the aspects of observing, formulating hypotheses, determining variable, interpreting data and communicating increased as well.

Results of chopper-controlled discharge life cycling studies on lead acid batteries

NASA Technical Reports Server (NTRS)

Ewashinka, J. G.; Sidik, S. M.

1982-01-01

A group of 108 state of the art nominally 6 volt lead acid batteries were tested in a program of one charge/discharge cycle per day for over two years or to ultimate battery failure. The primary objective was to determine battery cycle life as a function of depth of discharge (25 to 75 percent), chopper frequency (100 to 1000 Hz), duty cycle (25 to 87.5 percent), and average discharge current (20 to 260 A). The secondary objective was to determine the types of battery failure modes, if any, were due to the above parameters. The four parameters above were incorporated in a statistically designed test program.

Ares I-X First Stage Separation Loads and Dynamics Reconstruction

NASA Technical Reports Server (NTRS)

Demory, Lee; Rooker, BIll; Jarmulowicz, Marc; Glaese, John

2011-01-01

The Ares I-X flight test provided NASA with the opportunity to test hardware and gather critical data to ensure the success of future Ares I flights. One of the primary test flight objectives was to evaluate the environment during First Stage separation to better understand the conditions that the J-2X second stage engine will experience at ignition [1]. A secondary objective was to evaluate the effectiveness of the stage separation motors. The Ares I-X flight test vehicle was successfully launched on October 29, 2009, achieving most of its primary and secondary test objectives. Ground based video camera recordings of the separation event appeared to show recontact of the First Stage and the Upper Stage Simulator followed by an unconventional tumbling of the Upper Stage Simulator. Closer inspection of the videos and flight test data showed that recontact did not occur. Also, the motion during staging was as predicted through CFD analysis performed during the Ares I-X development. This paper describes the efforts to reconstruct the vehicle dynamics and loads through the staging event by means of a time integrated simulation developed in TREETOPS, a multi-body dynamics software tool developed at NASA [2]. The simulation was built around vehicle mass and geometry properties at the time of staging and thrust profiles for the first stage solid rocket motor as well as for the booster deceleration motors and booster tumble motors. Aerodynamic forces were determined by models created from a combination of wind tunnel testing and CFD. The initial conditions such as position, velocity, and attitude were obtained from the Best Estimated Trajectory (BET), which is compiled from multiple ground based and vehicle mounted instruments. Dynamic loads were calculated by subtracting the inertial forces from the applied forces. The simulation results were compared to the Best Estimated Trajectory, accelerometer flight data, and to ground based video.

Testing the utility of three social-cognitive models for predicting objective and self-report physical activity in adults with type 2 diabetes.

PubMed

Plotnikoff, Ronald C; Lubans, David R; Penfold, Chris M; Courneya, Kerry S

2014-05-01

Theory-based interventions to promote physical activity (PA) are more effective than atheoretical approaches; however, the comparative utility of theoretical models is rarely tested in longitudinal designs with multiple time points. Further, there is limited research that has simultaneously tested social-cognitive models with self-report and objective PA measures. The primary aim of this study was to test the predictive ability of three theoretical models (social cognitive theory, theory of planned behaviour, and protection motivation theory) in explaining PA behaviour. Participants were adults with type 2 diabetes (n = 287, 53.8% males, mean age = 61.6 ± 11.8 years). Theoretical constructs across the three theories were tested to prospectively predict PA behaviour (objective and self-report) across three 6-month time intervals (baseline-6, 6-12, 12-18 months) using structural equation modelling. PA outcomes were steps/3 days (objective) and minutes of MET-weighted PA/week (self-report). The mean proportion of variance in PA explained by these models was 6.5% for objective PA and 8.8% for self-report PA. Direct pathways to PA outcomes were stronger for self-report compared with objective PA. These theories explained a small proportion of the variance in longitudinal PA studies. Theory development to guide interventions for increasing and maintaining PA in adults with type 2 diabetes requires further research with objective measures. Theory integration across social-cognitive models and the inclusion of ecological levels are recommended to further explain PA behaviour change in this population. Statement of contribution What is already known on this subject? Social-cognitive theories are able to explain partial variance for physical activity (PA) behaviour. What does this study add? The testing of three theories in a longitudinal design over 3, 6-month time intervals. The parallel use and comparison of both objective and self-report PA measures in testing these theories. © 2013 The British Psychological Society.

HO(x) Measurements in PEM Tropics B with the Airborne Tropospheric Hydrogen Oxides Sensor (ATHOS)

NASA Technical Reports Server (NTRS)

Brune, William H.

2001-01-01

The primary objective of PEM Tropics B was to study the processes responsible for the production and loss of tropospheric ozone over the tropical Pacific. This region of the globe contains very clean air as well as aged, polluted air that was advected from both the Asian and American continents. Understanding ozone requires understanding of HO(x) (HO(x) = OH + HO2) chemistry, since the reaction between H02 and NO leads to ozone production and the production of OH often requires ozone loss. In addition, OH is the atmosphere's primary oxidant. Since most atmospheric oxidation is thought to occur in the tropical lower troposphere, measurements during PEM Tropics B should provide an important test of the OH abundances and distributions. Thus, understanding and thoroughly testing HO(x) processes was an important objective of PEM Tropics B. Several issues need to be tested, One is HO, production rates and sources, since HO,, production directly affects ozone production and loss. Another is HO(x) behavior in and around clouds, since HO(x) is lost to cloud particles, but convection may bring HO(x) precursors from near the surface to the upper troposphere. A third is the rise and fall of HO(x) at sunrise and sunset, since these variations give strong indications of the important sources and sinks of HO(x). Making and interpreting high-quality OH and H02 measurements from the NASA DC-8 during PEM Tropics B is the objective of this research effort.

Do primary health centres and hospitals contribute equally towards achievement of the transversal clinical competencies of medical students? Performance on the Objective Structured Clinical Examination (OSCE) in competency acquisition.

PubMed

Soler-González, Jorge; Buti, Miquel; Boada, Jordi; Ayala, Victoria; Peñascal, Eduard; Rodriguez, Toni

2016-01-01

The adaptation of the educational programmes of European faculties of medicine to the European Higher Education Area guidelines has focused curricula design on competence acquisition. Competencies are defined as the achievements of a predetermined level of efficacy in real-world scenarios. Our objective was to assess whether performance on a common competence evaluation test, the Objective Structured Clinical Examination (OSCE), resulted in different scores for second-year students after a practical medical training course took place in a primary health centre (PHC) or in a hospital. A descriptive study was conducted during the 2010-2014 academic year of the OSCE test scores obtained by all second-year students. Faculty of Medicine at the University of Lleida (Catalonia, Spain). We performed a correlation analysis between students who completed their practical medical training at the PHC and hospitals utilising Student's t-test for comparison of means. 423 students who completed internships at the PHC and at hospitals obtained OSCE mean scores of 7.32 (SD; IC) (0.82; 7.18-7.47) points and 7.17 (0.83; 6.07-7.26) points, respectively (p=0.07). Second-year medical students acquired similar competency levels in the two analysed training scenarios. The two areas both serve their teaching purpose. Copyright © 2014 Elsevier España, S.L.U. All rights reserved.

How does study quality affect the results of a diagnostic meta-analysis?

PubMed Central

Westwood, Marie E; Whiting, Penny F; Kleijnen, Jos

2005-01-01

Background The use of systematic literature review to inform evidence based practice in diagnostics is rapidly expanding. Although the primary diagnostic literature is extensive, studies are often of low methodological quality or poorly reported. There has been no rigorously evaluated, evidence based tool to assess the methodological quality of diagnostic studies. The primary objective of this study was to determine the extent to which variations in the quality of primary studies impact the results of a diagnostic meta-analysis and whether this differs with diagnostic test type. A secondary objective was to contribute to the evaluation of QUADAS, an evidence-based tool for the assessment of quality in diagnostic accuracy studies. Methods This study was conducted as part of large systematic review of tests used in the diagnosis and further investigation of urinary tract infection (UTI) in children. All studies included in this review were assessed using QUADAS, an evidence-based tool for the assessment of quality in systematic reviews of diagnostic accuracy studies. The impact of individual components of QUADAS on a summary measure of diagnostic accuracy was investigated using regression analysis. The review divided the diagnosis and further investigation of UTI into the following three clinical stages: diagnosis of UTI, localisation of infection, and further investigation of the UTI. Each stage used different types of diagnostic test, which were considered to involve different quality concerns. Results Many of the studies included in our review were poorly reported. The proportion of QUADAS items fulfilled was similar for studies in different sections of the review. However, as might be expected, the individual items fulfilled differed between the three clinical stages. Regression analysis found that different items showed a strong association with test performance for the different tests evaluated. These differences were observed both within and between the three clinical stages assessed by the review. The results of regression analyses were also affected by whether or not a weighting (by sample size) was applied. Our analysis was severely limited by the completeness of reporting and the differences between the index tests evaluated and the reference standards used to confirm diagnoses in the primary studies. Few tests were evaluated by sufficient studies to allow meaningful use of meta-analytic pooling and investigation of heterogeneity. This meant that further analysis to investigate heterogeneity could only be undertaken using a subset of studies, and that the findings are open to various interpretations. Conclusion Further work is needed to investigate the influence of methodological quality on the results of diagnostic meta-analyses. Large data sets of well-reported primary studies are needed to address this question. Without significant improvements in the completeness of reporting of primary studies, progress in this area will be limited. PMID:15943861

A Comparison of Quasi-Static Indentation and Drop-Weight Impact Testing on Carbon-Epoxy Laminates

NASA Technical Reports Server (NTRS)

Prabhakaran, R.

2001-01-01

The project had two objectives: 1) The primary objective was to characterize damage tolerance of composite materials. To accomplish this, polymer matrix composites were to be subjected to static indentation as well as low-velocity impacts and the results analyzed. 2) A second objective was to investigate the effects of laser shock peening on the damage tolerance of aerospace materials, such as aluminum alloys, in terms of crack nucleation and crack propagation. The impact testing was proposed to be performed using a Dynatup drop tower. The specimens were to be placed over a square opening in a steel platen and impacted with a hemispherical tup. The damage was to be characterized in the laminate specimens. The damage tolerance of aerospace alloys was to be studied by conducting fatigue tests on aluminum alloy specimens with prior shock peening treatment. The crack length was to be monitored by a microscope and the crack propagation rate, da/dN, determined.

Comparison of Orion Vision Navigation Sensor Performance from STS-134 and the Space Operations Simulation Center

NASA Technical Reports Server (NTRS)

Christian, John A.; Patangan, Mogi; Hinkel, Heather; Chevray, Keiko; Brazzel, Jack

2012-01-01

The Orion Multi-Purpose Crew Vehicle is a new spacecraft being designed by NASA and Lockheed Martin for future crewed exploration missions. The Vision Navigation Sensor is a Flash LIDAR that will be the primary relative navigation sensor for this vehicle. To obtain a better understanding of this sensor's performance, the Orion relative navigation team has performed both flight tests and ground tests. This paper summarizes and compares the performance results from the STS-134 flight test, called the Sensor Test for Orion RelNav Risk Mitigation (STORRM) Development Test Objective, and the ground tests at the Space Operations Simulation Center.

Everyday uses of standardized test information in a geriatric setting: a qualitative study exploring occupational therapist and physiotherapist test administrators' justifications.

PubMed

Krohne, Kariann; Torres, Sandra; Slettebø, Åshild; Bergland, Astrid

2014-02-17

Health professionals are required to collect data from standardized tests when assessing older patients' functional ability. Such data provide quantifiable documentation on health outcomes. Little is known, however, about how physiotherapists and occupational therapists who administer standardized tests use test information in their daily clinical work. This article aims to investigate how test administrators in a geriatric setting justify the everyday use of standardized test information. Qualitative study of physiotherapists and occupational therapists on two geriatric hospital wards in Norway that routinely tested their patients with standardized tests. Data draw on seven months of fieldwork, semi-structured interviews with eight physiotherapists and six occupational therapists (12 female, two male), as well as observations of 26 test situations. Data were analyzed using Systematic Text Condensation. We identified two test information components in everyday use among physiotherapist and occupational therapist test administrators. While the primary component drew on the test administrators' subjective observations during testing, the secondary component encompassed the communication of objective test results and test performance. The results of this study illustrate the overlap between objective and subjective data in everyday practice. In clinical practice, by way of the clinicians' gaze on how the patient functions, the subjective and objective components of test information are merged, allowing individual characteristics to be noticed and made relevant as test performance justifications and as rationales in the overall communication of patient needs.

The development of an augmentor wing jet STOL research aircraft (modified C-8A). Volume 2: Analysis of contractor's flight test

NASA Technical Reports Server (NTRS)

Skavdahl, H.; Patterson, D. H.

1972-01-01

The initial flight test phase of the modified C-8A airplane was conducted. The primary objective of the testing was to establish the basic airworthiness of the research vehicle. This included verification of the structural design and evaluation of the aircraft's systems. Only a minimum amount of performance testing was scheduled; this has been used to provide a preliminary indication of the airplane's performance and flight characteristics for future flight planning. The testing included flutter and loads investigations up to the maximum design speed. The operational characteristics of all systems were assessed including hydraulics, environmental control system, air ducts, the vectoring conical nozzles, and the stability augmentation system (SAS). Approaches to stall were made at three primary flap settings: up, 30 deg and 65 deg, but full stalls were not scheduled. Minimum control speeds and maneuver margins were checked. All takeoffs and landings were conventional, and STOL performance was not scheduled during this phase of the evaluation.

Sasquatch Footprint Tool

NASA Technical Reports Server (NTRS)

Bledsoe, Kristin

2013-01-01

The Crew Exploration Vehicle Parachute Assembly System (CPAS) is the parachute system for NASA s Orion spacecraft. The test program consists of numerous drop tests, wherein a test article rigged with parachutes is extracted or released from an aircraft. During such tests, range safety is paramount, as is the recoverability of the parachutes and test article. It is crucial to establish an aircraft release point that will ensure that the article and all items released from it will land in safe locations. A new footprint predictor tool, called Sasquatch, was created in MATLAB. This tool takes in a simulated trajectory for the test article, information about all released objects, and atmospheric wind data (simulated or actual) to calculate the trajectories of the released objects. Dispersions are applied to the landing locations of those objects, taking into account the variability of winds, aircraft release point, and object descent rate. Sasquatch establishes a payload release point (e.g., where the payload will be extracted from the carrier aircraft) that will ensure that the payload and all objects released from it will land in a specified cleared area. The landing locations (the final points in the trajectories) are plotted on a map of the test range. Sasquatch was originally designed for CPAS drop tests and includes extensive information about both the CPAS hardware and the primary test range used for CPAS testing. However, it can easily be adapted for more complex CPAS drop tests, other NASA projects, and commercial partners. CPAS has developed the Sasquatch footprint tool to ensure range safety during parachute drop tests. Sasquatch is well correlated to test data and continues to ensure the safety of test personnel as well as the safe recovery of all equipment. The tool will continue to be modified based on new test data, improving predictions and providing added capability to meet the requirements of more complex testing.

Superconducting gravity gradiometer mission. Volume 1: Study team executive summary

NASA Technical Reports Server (NTRS)

Morgan, Samuel H. (Editor); Paik, Ho Jung (Editor)

1989-01-01

An executive summary is presented based upon the scientific and engineering studies and developments performed or directed by a Study Team composed of various Federal and University activities involved with the development of a three-axis Superconducting Gravity Gradiometer integrated with a six-axis superconducting accelerometer. This instrument is being developed for a future orbital mission to make precise global gravity measurements. The scientific justification and requirements for such a mission are discussed. This includes geophysics, the primary mission objective, as well as secondary objectives, such as navigation and tests of fundamental laws of physics, i.e., a null test of the inverse square law of gravitation and tests of general relativity. The instrument design and status along with mission analysis, engineering assessments, and preliminary spacecraft concepts are discussed. In addition, critical spacecraft systems and required technology advancements are examined. The mission requirements and an engineering assessment of a precursor flight test of the instrument are discussed.

Effect of reaction control system jet-flow field interactions on a 0.015 scale model space shuttle orbiter aerodynamic characteristics

NASA Technical Reports Server (NTRS)

Monta, W. J.; Rausch, J. R.

1973-01-01

The effects of the reaction control system (RCS) jet-flow field interactions on the space shuttle orbiter system during entry are discussed. The primary objective of the test program was to obtain data for the shuttle orbiter configuration to determine control amplification factors resulting from jet interaction between the RCS plumes and the external flow over the vehicle. A secondary objective was to provide data for comparison and improvement of analytic jet interaction prediction techniques. The test program was divided into two phases; (1) force and moment measurements were made with and without RCS blowing, investigating environment parameters (R sub e, Alpha, Beta), RCS plume parameters (Jet pressure ratio, momentum ratio and thrust level), and geometry parameters (RCS pod locations) on the orbiter model, (2) oil flow visualization tests were conducted on a dummy balance at the end of the test.

Anodal transcranial direct current stimulation enhances the effects of motor imagery training in a finger tapping task.

PubMed

Saimpont, Arnaud; Mercier, Catherine; Malouin, Francine; Guillot, Aymeric; Collet, Christian; Doyon, Julien; Jackson, Philip L

2016-01-01

Motor imagery (MI) training and anodal transcranial direct current stimulation (tDCS) applied over the primary motor cortex can independently improve hand motor function. The main objective of this double-blind, sham-controlled study was to examine whether anodal tDCS over the primary motor cortex could enhance the effects of MI training on the learning of a finger tapping sequence. Thirty-six right-handed young human adults were assigned to one of three groups: (i) who performed MI training combined with anodal tDCS applied over the primary motor cortex; (ii) who performed MI training combined with sham tDCS; and (iii) who received tDCS while reading a book. The MI training consisted of mentally rehearsing an eight-item complex finger sequence for 13 min. Before (Pre-test), immediately after (Post-test 1), and at 90 min after (Post-test 2) MI training, the participants physically repeated the sequence as fast and as accurately as possible. An anova showed that the number of sequences correctly performed significantly increased between Pre-test and Post-test 1 and remained stable at Post-test 2 in the three groups (P < 0.001). Furthermore, the percentage increase in performance between Pre-test and Post-test 1 and Post-test 2 was significantly greater in the group that performed MI training combined with anodal tDCS compared with the other two groups (P < 0.05). As a potential physiological explanation, the synaptic strength within the primary motor cortex could have been reinforced by the association of MI training and tDCS compared with MI training alone and tDCS alone. © 2015 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

NASA-DoD Lead-Free Electronics Project

NASA Technical Reports Server (NTRS)

Kessel, Kurt

2007-01-01

The primary technical objective of the project is to undertake comprehensive testing to generate information on failure modes/criteria to better understand the reliability of: Packages (e.g., TSOP, BGA, PDIP) assembled and reworked with lead-free alloys Packages (e.g., TSOP, BGA, PDIP) assembled and reworked with mixed (lead/lead-free) alloys.

Experiences of Teacher Evaluation Systems on High School Physical Education Programs

ERIC Educational Resources Information Center

Phillips, Sharon R.; Mercier, Kevin; Doolittle, Sarah

2017-01-01

Primary objective: Teacher evaluation is being revamped by policy-makers. The marginalized status of physical education has protected this subject area from reform for many decades, but in our current era of system-wide, data-based decision-making, physical education is no longer immune. Standardized and local testing, together with structured…

A Randomized Effectiveness Trial of Brief Cognitive-Behavioral Therapy for Depressed Adolescents Receiving Antidepressant Medication

ERIC Educational Resources Information Center

Clarke, Gregory; DeBar, Lynn; Lynch, Frances; Powell, James; Gale, John; O'Connor, Elizabeth; Ludman, Evette; Bush, Terry; Lin, Elizabeth H. B.; Von Korff, Michael; Hertert, Stephanie

2005-01-01

Objective: To test a collaborative-care, cognitive-behavioral therapy (CBT) program adjunctive to selective serotonin reuptake inhibitor (SSRI) treatment in HMO pediatric primary care. Method: A randomized effectiveness trial comparing a treatment-as-usual (TAU) control condition consisting primarily of SSRI medication delivered outside the…

National Testing of Pupils in Europe: Objectives, Organisation and Use of Results. Greece 2009

ERIC Educational Resources Information Center

Eurydice, 2009

2009-01-01

Pupil assessment procedures and methods in Greece are set and "standardized" externally by the central authorities as defined in the legislative framework, the National Curriculum guidelines and teachers' manuals, while implementation is internal to the schools. The focus of primary schools is on formative assessment, while the lower…

Effects of Earthworm (Eisenia fetida) and Wheat (Triticum aestivum) Straw Additions on Selected Properties of Petroleum-Contaminated Soils

Treesearch

Mac A. Callaham; Arthur J. Stewart; Clara Alarcon; Sara J. McMillen

2002-01-01

Current bioremediation techniques for petroleum-contaminated soils are designed to remove contaminants as quickly and efficiently as possible, but not necessarily with postremediation soil biological quality as a primary objective. To test a simple postbioremediation technique, we added earthworms (Eisenia fetida) or wheat (Triticum aestivum...

Automated biowaste sampling system urine subsystem operating model, part 1

NASA Technical Reports Server (NTRS)

Fogal, G. L.; Mangialardi, J. K.; Rosen, F.

1973-01-01

The urine subsystem automatically provides for the collection, volume sensing, and sampling of urine from six subjects during space flight. Verification of the subsystem design was a primary objective of the current effort which was accomplished thru the detail design, fabrication, and verification testing of an operating model of the subsystem.

A Model for Predicting Learning Flow and Achievement in Corporate e-Learning

ERIC Educational Resources Information Center

Joo, Young Ju; Lim, Kyu Yon; Kim, Su Mi

2012-01-01

The primary objective of this study was to investigate the determinants of learning flow and achievement in corporate online training. Self-efficacy, intrinsic value, and test anxiety were selected as learners' motivational factors, while perceived usefulness and ease of use were also selected as learning environmental factors. Learning flow was…

ENVIROGEN PROPANE BIOSTIMULATION TECHNOLOGY FOR THE IN-SITU TREATMENT OF MTBE-CONTAMINATED GROUND WATER INNOVATIVE TECHNOLOGY EVALUATION REPORT

EPA Science Inventory

The primary objective of the Biostimulation Technology Evaluation was to determine if biodegradation was occurring in a ground-water Test Plot to a sufficient degree to reduce intrinsic MTBE to the State of California's treatability criteria of 5 mg/L or below. The evaluation wa...

A Theory-Grounded Measure of Adolescents' Response to a Media Literacy Intervention

ERIC Educational Resources Information Center

Greene, Kathryn; Yanovitzky, Itzhak; Carpenter, Amanda; Banerjee, Smita C.; Magsamen-Conrad, Kate; Hecht, Michael L.; Elek, Elvira

2015-01-01

Media literacy interventions offer promising avenues for the prevention of risky health behaviors among children and adolescents, but current literature remains largely equivocal about their efficacy. The primary objective of this study was to develop and test theoretically-grounded measures of audiences' degree of engagement with the content of…

Ohio Social Studies Curriculum Guide: Washington Middle School. 1984-1989.

ERIC Educational Resources Information Center

Taylor, John P.

Designed for use in a one-semester seventh-grade Ohio social studies class, this curriculum guide is divided into teaching, testing, and activity units. The primary purposes of this guide are to teach participatory citizenship and to emphasize self-learning. Twelve broad instructional objectives include the ability to: (1) interpret Article I of…

Unified Database Development Program. Final Report.

ERIC Educational Resources Information Center

Thomas, Everett L., Jr.; Deem, Robert N.

The objective of the unified database (UDB) program was to develop an automated information system that would be useful in the design, development, testing, and support of new Air Force aircraft weapon systems. Primary emphasis was on the development of: (1) a historical logistics data repository system to provide convenient and timely access to…

Development and evaluation of a dual purpose bridge health monitoring and weigh-in-motion system for a steel girder bridge : phase two.

DOT National Transportation Integrated Search

2016-06-30

The primary objective of this second phase is the further development, demonstration : and field evaluation of a permanent dual purpose bridge weigh-in-motion and health monitoring : system over an extended period of time. Calibrated test truck resul...

Comparison of the pattern, efficacy, and tolerability of self-medicated drugs in primary dysmenorrhea: A questionnaire based survey

PubMed Central

Sugumar, Ramya; Krishnaiah, Vasundara; Channaveera, Gokul Shetty; Mruthyunjaya, Shilpa

2013-01-01

Objective: To compare the pattern, efficacy, and tolerability of self-medicated drugs and to assess the adequacy of their dose in primary dysmenorrhea (PD). Materials and Methods: A survey using a self-developed, validated, objective, and structured questionnaire as a tool was conducted among subjects with PD. Statistical analysis was carried out using Chi-square test and ANOVA with post-hoc Tuckey's test. Results: Out of 641 respondents, 42% were self-medicated. The pattern of drugs used was: Dicyclomine, an unknown drug, mefenamic acid, mefenamic acid + dicyclomine, and metamizole by 35%, 29%, 26%, 9%, and 1% of respondents, respectively. Mefenamic acid + dicyclomine, the combination was the most efficacious in comparison to other drugs in moderate to severe dysmenorrhea. There was better tolerability with mefenamic acid + dicyclomine group compared to other drugs. Sub-therapeutic doses were used by 86% of self-medicating respondents. Conclusions: The prevailing self-medication practices were inappropriate in a substantial proportion of women with inadequate knowledge regarding appropriate drug choice, therapeutic doses, and their associated side effects. PMID:23716896

Investigating Image Formation with a Camera Obscura: a Study in Initial Primary Science Teacher Education

NASA Astrophysics Data System (ADS)

Muñoz-Franco, Granada; Criado, Ana María; García-Carmona, Antonio

2018-04-01

This article presents the results of a qualitative study aimed at determining the effectiveness of the camera obscura as a didactic tool to understand image formation (i.e., how it is possible to see objects and how their image is formed on the retina, and what the image formed on the retina is like compared to the object observed) in a context of scientific inquiry. The study involved 104 prospective primary teachers (PPTs) who were being trained in science teaching. To assess the effectiveness of this tool, an open questionnaire was applied before (pre-test) and after (post-test) the educational intervention. The data were analyzed by combining methods of inter- and intra-rater analysis. The results showed that more than half of the PPTs advanced in their ideas towards the desirable level of knowledge in relation to the phenomena studied. The conclusion reached is that the camera obscura, used in a context of scientific inquiry, is a useful tool for PPTs to improve their knowledge about image formation and experience in the first person an authentic scientific inquiry during their teacher training.

Testing and Comparative Evaluation of Space Shuttle Main Engine Flowmeter Bearings

NASA Technical Reports Server (NTRS)

Hissam, Andy; Leberman, Mike; McLeroy, Rick

2005-01-01

This paper provides a summary of testing of Space Shuttle Main Engine (SSME) flowmeter bearings and cage material. These tests were con&cM over a several month period in 2004 at the Marshall Space Flight Center. The test program's primary objective was to compare the performance of bearings using the existing cage material and bearings using a proposed replacement cage material. In order to meet the test objectives for this program, a flowmeter test rig was designed and fabricated to measure both breakaway and running torque for a flowmeter assembly. Other test parameters,,such as motor current and shaft speed, were also recorded and provide a means of comparing bearing performance. The flowmeter and bearings were tested in liquid hydrogen to simulate the flowmeter's operating environment as closely as possible. Based on the results from this testing, the bearings with the existing cage material are equivalent to the bearings with the proposed replacement cage material. No major differences exist between the old and new cage materials. Therefore, the new cage material is a suitable replacement for the existing cage material.

Aerodynamic results of wind tunnel tests on a 0.010-scale model (32-QTS) space shuttle integrated vehicle in the AEDC VKF-40-inch supersonic wind tunnel (IA61)

NASA Technical Reports Server (NTRS)

Daileda, J. J.

1976-01-01

Plotted and tabulated aerodynamic coefficient data from a wind tunnel test of the integrated space shuttle vehicle are presented. The primary test objective was to determine proximity force and moment data for the orbiter/external tank and solid rocket booster (SRB) with and without separation rockets firing for both single and dual booster runs. Data were obtained at three points (t = 0, 1.25, and 2.0 seconds) on the nominal SRB separation trajectory.

CFD Analysis of Flexible Thermal Protection System Shear Configuration Testing in the LCAT Facility

NASA Technical Reports Server (NTRS)

Ferlemann, Paul G.

2014-01-01

This paper documents results of computational analysis performed after flexible thermal protection system shear configuration testing in the LCAT facility. The primary objectives were to predict the shear force on the sample and the sensitivity of all surface properties to the shape of the sample. Bumps of 0.05, 0.10,and 0.15 inches were created to approximate the shape of some fabric samples during testing. A large amount of information was extracted from the CFD solutions for comparison between runs and also current or future flight simulations.

Student Loan Debt Does Not Predict Female Physicians’ Choice of Primary Care Specialty

PubMed Central

Frank, Erica; Feinglass, Shamiram

1999-01-01

OBJECTIVE There has never been a conclusive test of whether there is a relation between ultimately choosing to be a primary care physician and one’s amount of student loan debt at medical school graduation. DESIGN/SETTING/PARTICIPANTS To test this question, we examined data from the Women Physicians’ Health Study, a large, nationally representative, questionnaire-based study of 4,501 U.S. women physicians. MEASUREMENTS AND MAIN RESULTS We found that the youngest physicians were more than five times as likely as the oldest to have had some student loan debt and far more likely to have had high debt levels (p < .0001). However, younger women physicians were also more likely to choose a primary care specialty (p < .002). There was no relation between being a primary care physician and amount of indebtedness (p = .77); this was true even when the results were adjusted for the physicians’ decade of graduation and ethnicity (p = .79). CONCLUSIONS Although there may be other reasons for reducing student loan debt, at least among U.S. women physicians, encouraging primary care as a specialty choice may not be a reason for doing so. PMID:10354254

Apixaban for reduction in stroke and other ThromboemboLic events in atrial fibrillation (ARISTOTLE) trial: design and rationale.

PubMed

Lopes, Renato D; Alexander, John H; Al-Khatib, Sana M; Ansell, Jack; Diaz, Raphael; Easton, J Donald; Gersh, Bernard J; Granger, Christopher B; Hanna, Michael; Horowitz, John; Hylek, Elaine M; McMurray, John J V; Verheugt, Freek W A; Wallentin, Lars

2010-03-01

Atrial fibrillation (AF) is associated with increased risk of stroke that can be attenuated with vitamin K antagonists (VKAs). Vitamin K antagonist use is limited, in part, by the high incidence of complications when patients' international normalized ratios (INRs) deviate from the target range. The primary objective of ARISTOTLE is to determine if the factor Xa inhibitor, apixaban, is noninferior to warfarin at reducing the combined endpoint of stroke (ischemic or hemorrhagic) and systemic embolism in patients with AF and at least 1 additional risk factor for stroke. We have randomized 18,206 patients from over 1,000 centers in 40 countries. Patients were randomly assigned in a 1:1 ratio to receive apixaban or warfarin using a double-blind, double-dummy design. International normalized ratios are monitored and warfarin (or placebo) is adjusted aiming for a target INR range of 2 to 3 using a blinded, encrypted point-of-care device. Minimum treatment is 12 months, and maximum expected exposure is 4 years. Time to accrual of at least 448 primary efficacy events will determine treatment duration. The key secondary objectives are to determine if apixaban is superior to warfarin for the combined endpoint of stroke (ischemic or hemorrhagic) and systemic embolism, and for all-cause death. These will be tested after the primary objective using a closed test procedure. The noninferiority boundary is 1.38; apixaban will be declared noninferior if the 95% CI excludes the possibility that the primary outcome rate with apixaban is >1.38 times higher than with warfarin. ARISTOTLE will determine whether apixaban is noninferior or superior to warfarin in preventing stroke and systemic embolism; whether apixaban has particular benefits in the warfarin-naïve population; whether it reduces the combined rate of stroke, systemic embolism, and death; and whether it impacts bleeding.

Underground coal mine instrumentation and test

NASA Technical Reports Server (NTRS)

Burchill, R. F.; Waldron, W. D.

1976-01-01

The need to evaluate mechanical performance of mine tools and to obtain test performance data from candidate systems dictate that an engineering data recording system be built. Because of the wide range of test parameters which would be evaluated, a general purpose data gathering system was designed and assembled to permit maximum versatility. A primary objective of this program was to provide a specific operating evaluation of a longwall mining machine vibration response under normal operating conditions. A number of mines were visited and a candidate for test evaluation was selected, based upon management cooperation, machine suitability, and mine conditions. Actual mine testing took place in a West Virginia mine.

Space station systems analysis study. Part 2, Volume 3: Appendixes, Book 1. Program requirements documentation

NASA Technical Reports Server (NTRS)

1977-01-01

The objective elements representative of the kinds of space activities that will be supported by the space construction base (SCB) are discussed in (1) a brief mission overview including the primary purpose and general objectives; (2) descriptions of the processes involved (where applicable), the mission hardware, the principal activities to be undertaken, the test requirements, and the principal tests; and (3) the SCB requirements including such items as special devices (e.g., fabrication modules, assembly or construction fixtures, cranes, and airlocks), power, data management and communications, waste management, environmental control, safety, and logistics. Each program option is then described in terms of the objective elements it supports, its orbit, the general makeup of the SCB, the transportation approach, and the program schedule goals. The specific requirements that are imposed on the SCB in order to support program option L are given.

An Evaluative Study of Primary Education in the Light of Policies and Plans in Pakistan (1947-2006)

ERIC Educational Resources Information Center

Parveen, Shahida

2008-01-01

The paper is based on a research conducted to evaluate primary education in the light of education policies and plans in Pakistan. This article discusses the objectives of primary education, and analyzes different education policies and plans regarding the achievements of objectives. Results revealed that the objectives of primary education were…

Description of the Prometheus Program Alternator/Thruster Integration Laboratory (ATIL)

NASA Technical Reports Server (NTRS)

Baez, Anastacio N.; Birchenough, Arthur G.; Lebron-Velilla, Ramon C.; Gonzalez, Marcelo C.

2005-01-01

The Project Prometheus Alternator Electric Thruster Integration Laboratory's (ATIL) primary two objectives are to obtain test data to influence the power conversion and electric propulsion systems design, and to assist in developing the primary power quality specifications prior to system Preliminary Design Review (PDR). ATIL is being developed in stages or configurations of increasing fidelity and complexity in order to support the various phases of the Prometheus program. ATIL provides a timely insight of the electrical interactions between a representative Permanent Magnet Generator, its associated control schemes, realistic electric system loads, and an operating electric propulsion thruster. The ATIL main elements are an electrically driven 100 kWe Alternator Test Unit (ATU), an alternator controller using parasitic loads, and a thruster Power Processing Unit (PPU) breadboard. This paper describes the ATIL components, its development approach, preliminary integration test results, and current status.

Final test results for the ground operations demonstration unit for liquid hydrogen

NASA Astrophysics Data System (ADS)

Notardonato, W. U.; Swanger, A. M.; Fesmire, J. E.; Jumper, K. M.; Johnson, W. L.; Tomsik, T. M.

2017-12-01

Described herein is a comprehensive project-a large-scale test of an integrated refrigeration and storage system called the Ground Operations and Demonstration Unit for Liquid Hydrogen (GODU LH2), sponsored by the Advanced Exploration Systems Program and constructed at Kennedy Space Center. A commercial cryogenic refrigerator interfaced with a 125,000 l liquid hydrogen tank and auxiliary systems in a manner that enabled control of the propellant state by extracting heat via a closed loop Brayton cycle refrigerator coupled to a novel internal heat exchanger. Three primary objectives were demonstrating zero-loss storage and transfer, gaseous liquefaction, and propellant densification. Testing was performed at three different liquid hydrogen fill-levels. Data were collected on tank pressure, internal tank temperature profiles, mass flow in and out of the system, and refrigeration system performance. All test objectives were successfully achieved during approximately two years of testing. A summary of the final results is presented in this paper.

Hover and forward flight acoustics and performance of a small-scale helicopter rotor system

NASA Technical Reports Server (NTRS)

Kitaplioglu, C.; Shinoda, P.

1985-01-01

A 2.1-m diam., 1/6-scale model helicopter main rotor was tested in hover in the test section of the NASA Ames 40- by 80- Foot Wind Tunnel. Subsequently, it was tested in forward flight in the Ames 7- by 10-Foot Wind Tunnel. The primary objective of the tests was to obtain performance and noise data on a small-scale rotor at various thrust coefficients, tip Mach numbers, and, in the later case, various advance ratios, for comparisons with similar existing data on full-scale helicopter rotors. This comparison yielded a preliminary evaluation of the scaling of helicopter rotor performance and acoustic radiation in hover and in forward flight. Correlation between model-scale and full-scale performance and acoustics was quite good in hover. In forward flight, however, there were significant differences in both performance and acoustic characteristics. A secondary objective was to contribute to a data base that will permit the estimation of facility effects on acoustic testing.

Micro-jitter attenuation of spaceborne cooler by using a blade-type hyperelastic shape memory alloy passive isolator

NASA Astrophysics Data System (ADS)

Kwon, Seong-Cheol; Jeon, Young-Hyeon; Oh, Hyun-Ung

2017-10-01

In this study, the primary design objective is to develop a passive isolator that can guarantee structural safety of the cooler assembly in a launch vibration environment without a launch locking mechanism, while effectively isolating the cooler-induced micro-jitter during the on-orbit operation of the cooler. To achieve the design objective, we focused on the utilization of characteristics of the hyperelastic shape memory effects. The major advantage of the isolator is that the micro-jitter isolation performance is much less sensitive to the aligned position of the isolator in comparison with the conventional isolator. Moreover, implementation of an additional 0g compensation device during a satellite level on-ground test, such as a jitter measurement test, is not required. In this study, the basic characteristics of the isolator were measured using the torque test and free vibration test. The micro-jitter attenuation capability and position sensitivity of the proposed isolator design were validated by the micro-jitter measurement test.

GPS Moving Vehicle Experiment

NASA Technical Reports Server (NTRS)

Oaks, O. J.; Reid, Wilson; Wright, James; Duffey, Christopher; Williams, Charles; Warren, Hugh; Zeh, Tom; Buisson, James

1996-01-01

The Naval Research Laboratory (NRL) in the development of timing systems for remote locations, had a technical requirement for a Y code (SA/AS) Global Positioning System (GPS) precise time transfer receiver (TTR) which could be used both in a stationary mode or mobile mode. A contract was awarded to the Stanford Telecommunication Corporation (STEL) to build such a device. The Eastern Range (ER) als had a requirement for such a receiver and entered into the contract with NRL for the procurement of additional receivers. The Moving Vehicle Experiment (MVE) described in this paper is the first in situ test of the STEL Model 5401C Time Transfer System in both stationary and mobile operations. The primary objective of the MVE was to test the timing accuracy of the newly developed GPS TTR aboard a moving vessel. To accomplish this objective, a joint experiment was performed with personnel from NRL and the er at the Atlantic Undersea Test and Evaluation Center (AUTEC) test range at Andros Island. Results and discussion of the test are presented in this paper.

Neurocognitive Function in Children with Primary Hypertension

PubMed Central

Lande, Marc B.; Batisky, Donald L.; Kupferman, Juan C.; Samuels, Joshua; Hooper, Stephen R.; Falkner, Bonita; Waldstein, Shari R.; Szilagyi, Peter G.; Wang, Hongyue; Staskiewicz, Jennifer; Adams, Heather R.

2016-01-01

Objective To compare neurocognitive test performance of children with primary hypertension to that of normotensive controls. Study design Seventy-five children (10-18 years of age) with newly diagnosed, untreated hypertension and 75 frequency matched normotensive controls had baseline neurocognitive testing as part of a prospective multicenter study of cognition in primary hypertension. Subjects completed tests of general intelligence, attention, memory, executive function, and processing speed. Parents completed rating scales of executive function and the Sleep-Related Breathing Disorder scale of the Pediatric Sleep Questionnaire (PSQ-SRBD). Results Hypertension and control groups did not differ significantly in age, sex, maternal education, income, race, ethnicity, obesity, anxiety, depression, cholesterol, glucose, insulin, and C-reactive protein. Subjects with hypertension had higher PSQ-SRBD scores (p = 0.04) and triglycerides (p = 0.037). Multivariate analyses showed that hypertension was independently associated with worse performance on the Rey Auditory Verbal Learning Test (List A Trial 1, p = 0.034; List A Total, p = 0.009; Short delay recall, p = 0.013), CogState Groton Maze Learning Test delayed recall (p = 0.002), Grooved Pegboard dominant hand (p = 0.045), and Wechsler Abbreviated Scales of Intelligence Vocabulary (p = 0.016). Results indicated a significant interaction between disordered sleep (PSQ-SRBD score) and hypertension on ratings of executive function (p = 0.04), such that hypertension heightened the association between increased disordered sleep and worse executive function. Conclusions Youth with primary hypertension demonstrated significantly lower performance on neurocognitive testing compared with normotensive controls, in particular, on measures of memory, attention, and executive functions. PMID:27692987

How reliable are self-reports of HIV status disclosure? Evidence from couples in Malawi

PubMed Central

Conroy, Amy A.; Wong, Lauren H.

2015-01-01

Introduction The majority of research on human immunodeficiency virus (HIV) disclosure utilizes the perspective from a single individual, which cannot be substantiated in the absence of supporting data such as from a primary partner. Objectives The objectives of this study were to evaluate: (1) the extent to which self-reported HIV disclosure was confirmed by a primary partner; (2) individual and relationship-level predictors of self-reported versus confirmed disclosure; and (3) whether confirmed disclosure was a stronger predictor of correctly assessing a partner's HIV status compared to self-reported disclosure. Methods As part of an 8-wave longitudinal study from 2009-2011 in southern Malawi, 366 individuals (183 couples) were interviewed about their primary relationship (wave 3), individually tested for HIV (wave 4), and then asked whether they disclosed to their primary partner (wave 5). Results While 93% of respondents reported that they disclosed, only 64% of respondents had confirmed reports from their partner. Having communicated with partner about HIV was positively associated with self-reported disclosure; this association remained significant but became more precise in the models for confirmed disclosure. Confirmed disclosure, but not self-report, was a significant predictor of correctly assessing a partner's HIV status. Being male, having lower perceived partner infidelity, having higher relationship unity, and testing HIV-negative were positively and significantly associated with correct assessment. Dyadic data from two partners provide an improved measure of disclosure as compared to a single individual's self-report and could be used to identify behavioral and biomedical opportunities to prevent HIV transmission within couples. PMID:26379084

Louisiana (LA) Health: Design and Methods for a Childhood Obesity Prevention Program in Rural Schools

PubMed Central

Williamson, Donald A.; Champagne, Catherine M.; Harsha, David; Han, Hongmei; Martin, Corby K.; Newton, Robert; Stewart, Tiffany M.; Ryan, Donna H.

2008-01-01

There is a worldwide epidemic of obesity with far-reaching consequences for the health of our nation. Prevention of obesity, especially in children, has been deemed by public health policy makers to be one of the most important objectives for our country. This prevention project, called Louisiana (LA) Health, will test whether modification of environmental and behavioral factors can prevent inappropriate weight gain in children from rural parishes of Louisiana who are enrolled in the fourth to sixth grades during Year 1. The primary aim of the LA Health project is to test the efficacy of two school-based approaches for obesity prevention: primary prevention alone and a combination of primary and secondary prevention which will be compared to a no-intervention control group using a cluster randomization research design, with 17 school clusters randomly assigned to the three treatment arms. The study will span three years and will provide critical tests of strategies that: 1) modify the child’s environment as a primary prevention strategy and 2) provide health behavior modification via classroom instruction and internet counseling as a secondary prevention strategy. The study will also recruit a similar sample of students to measure changes in body weight relative to height, gender, and age over the same three-year period. PMID:18448393

Impact of a Pharmacist-Provided Spirometry Service on Access to Results in a Primary Care Setting.

PubMed

Mueller, Lisa A; Valentino, Alexa Sevin; Clark, Aaron D; Li, Junan

2018-01-01

The primary objective of this study was to determine the effect of a pharmacist-provided spirometry service within a federally qualified health center on the percentage of spirometry referrals completed with results reviewed by the ordering provider. Secondary objectives evaluated differences between internal and external referrals, medication recommendations made by the pharmacist, and revenue brought in by the service. Chart reviews were completed to determine the referral completion rates between patients who received a spirometry referral before (December 2014-September 2015) and after (January 2016-October 2016) the implementation of the pharmacy-provided spirometry service. Chart reviews were also used to determine the number and completion rate among referrals for internal and external services in the postimplementation time frame. Chart reviews also assessed medication recommendations made by the pharmacist. The results demonstrate an increase in referral completion rate from 38.1% to 47.0% ( P = .08) between the pre- and postimplementation time frames. In the postimplementation time frame, there was a statistically significant difference in the percentage of referrals completed between in-house referrals and external referrals (70.0% and 40.9%, respectively, P = .0004). Comparing clinics with and without the spirometry service, there was a statistically significant difference in the total number of spirometry referrals (1.13% and 0.59%, respectively, P < .0001) and the percent of referrals completed (0.55% and 0.27%, respectively, P = .0002). The results suggest that offering spirometry within the primary care setting helps to increase the rate of completed spirometry tests with results available to the primary care provider. Additionally, the results show that there is an increased completion rate in patients who receive an internal spirometry referral, which may be due to reduced barriers in obtaining this testing. Overall, these results demonstrate that providing spirometry in the primary care setting helps to increase spirometry results obtained and could be beneficial in other primary care settings.

[Comparison of screening performance between primary high-risk HPV screening and high-risk HPV screening plus liquid-based cytology cotesting in diagnosis of cervical precancerous or cancerous lesions].

PubMed

Zhao, X L; Remila, Rezhake; Hu, S Y; Zhang, L; Xu, X Q; Chen, F; Pan, Q J; Zhang, X; Zhao, F H

2018-05-06

Objective: To evaluate and compare the screening performance of primary high-risk HPV(HR-HPV) screening and HR-HPV screening plus liquid-based cytology (LBC) cotesting in diagnosis of cervical cancer and precancerous lesions (CIN2+). Methods: We pooled 17 population-based cross-sectional studies which were conducted across China from 1999 to 2008. After obtaining informed consent, all women received liquid-based cytology(LBC)testing, HR-HPV DNA testing. Totally 28 777 women with complete LBC, HPV and biopsy results were included in the final analysis. Screening performance of primary HR-HPV DNA screening and HPV screening plus LBC co-testing in diagnosis of CIN2+ were calculated and compared among different age groups. Results: Among the whole population, the detection rates of primary HR-HPV screening and HR-HPV screening plus LBC co-testing are 3.05% (879 CIN2+) and 3.13%(900 CIN2+), respectively. The sensitivity were 96.4% and 98.7% (χ(2)=19.00, P< 0.001), and the specificity were 86.2% and 78.8% (χ(2)=2 067.00, P< 0.001), respectively. Areas under the receiver operating characteristic (ROC) curve (AUC) showed that the primary HR-HPV screening performed better than co-testing (AUC were 0.913 and 0.888; Z= 6.16, P< 0.001). Compared with primary HR-HPV screening, co-testing showed significantly higher colposcopy referral rates (16.5% and 23.6%, respectively, χ(2)=132.00, P< 0.001) and the number of colposcopy examination for detecting per CIN2+ (5.4 and 7.6, respectively).In the group aged 25-29, the colposcopy referral rates was 8.7 (10.9%(199 cases) vs 1.3%(23 cases)) times as much as the detection rate of primary HR-HPV screening in diagnosis of CIN2+, and was 12.5 (15.7%(288 cases) vs 1.3%(23 cases)) times as much as the detection rate of HR-HPV screening plus cytology contesting. Conclusion: Compared with primary HR-HPV screening, HR-HPV screening plus cytology co-testing does not show better results in the screening performance for CIN2+ detection, and the cost-effectiveness is not good enough, especially in younger age group.

Interhemispheric Inhibition Measurement Reliability in Stroke: A Pilot Study

PubMed Central

Cassidy, Jessica M.; Chu, Haitao; Chen, Mo; Kimberley, Teresa J.; Carey, James R.

2016-01-01

Objective Reliable transcranial magnetic stimulation (TMS) measures for probing corticomotor excitability are important when assessing the physiological effects of non-invasive brain stimulation. The primary objective of this study was to examine test-retest reliability of an interhemispheric inhibition (IHI) index measurement in stroke. Materials and Methods Ten subjects with chronic stroke (≥ 6 months) completed two IHI testing sessions per week for three weeks (six testing sessions total). A single investigator measured IHI in the contra- to-ipsilesional primary motor cortex direction and in the opposite direction using bilateral paired-pulse TMS. Weekly sessions were separated by 24 hours with a 1-week washout period separating testing weeks. To determine if motor-evoked potential (MEP) quantification method affected measurement reliability, IHI indices computed from both MEP amplitude and area responses were found. Reliability was assessed with two-way, mixed intraclass correlation coefficients (ICC(3,k)). Standard error of measurement and minimal detectable difference statistics were also determined. Results With the exception of the initial testing week, IHI indices measured in the contra-to-ipsilesional hemisphere direction demonstrated moderate to excellent reliability (ICC = 0.725 – 0.913). Ipsi-to-contralesional IHI indices depicted poor or invalid reliability estimates throughout the three-week testing duration (ICC= −1.153 – 0.105). The overlap of ICC 95% confidence intervals suggested that IHI indices using MEP amplitude vs. area measures did not differ with respect to reliability. Conclusions IHI indices demonstrated varying magnitudes of reliability irrespective of MEP quantification method. Several strategies for improving IHI index measurement reliability are discussed. PMID:27333364

The effects of a team-based continuous quality improvement intervention on the management of primary care: a randomised controlled trial

PubMed Central

Engels, Yvonne; van den Hombergh, Pieter; Mokkink, Henk; van den Hoogen, Henk; van den Bosch, Wil; Grol, Richard

2006-01-01

Aim To study the effects of a team-based model for continuous quality improvement (CQI) on primary care practice management. Design of study Randomised controlled trial. Setting Twenty-six intervention and 23 control primary care practices in the Netherlands. Method Practices interested in taking part in the CQI project were, after assessment of their practice organisation, randomly assigned to the intervention or control groups. During a total of five meetings, a facilitator helped the teams in the intervention group select suitable topics for quality improvement and follow a structured approach to achieve improvement objectives. Checklists completed by an outreach visitor, questionnaires for the GPs, staff and patients were used to assemble data on the number and quality of improvement activities undertaken and on practice management prior to the start of the intervention and 1 year later. Results Pre-test and post-test data were compared for the 26 intervention and 23 control practices. A significant intervention effect was found for the number of improvement objectives actually defined (93 versus 54, P<0.001) and successfully completed (80 versus 69% of the projects, P<0.001). The intervention group also improved on more aspects of practice management, as measured by our practice visit method, than the control group but none of these differences proved statistically significant. Conclusion The intervention exerted a significant effect on the number and quality of improvement projects undertaken and self-defined objectives met. Failure of the effects of the intervention on the other dimensions of practice management to achieve significance may be due to the topics selected for some of the improvement projects being only partly covered by the assessment instrument. PMID:17007709

The Effect of Gender on the Construction of Backward Inferences

ERIC Educational Resources Information Center

Cakir, Ozler

2008-01-01

The main objective in the present study is to examine the effect of gender on primary school students' construction of elaborative backward inferences during text processing. A total of 333 children, aged 10-11 years (n = 158 girls and 175 boys) participated in the study. Each participant completed a backward inference test. The results indicate…

An Introduction to Project PRIME and CAMPUS MINNESOTA. Project PRIME Report, Number 2.

ERIC Educational Resources Information Center

Cordes, David C.

PRIME is an acronym for Planning Resources in Minnesota Education. The project's primary objective is to test the implementation of CAMPUS (Comprehensive Analytical Methods for Planning University Systems) in one State College, one Junior College, and in one school at the University of Minnesota. The CAMPUS model was developed by the Institute for…

A Parent-Only Group Intervention for Children with Anxiety Disorders: Pilot Study

ERIC Educational Resources Information Center

Thienemann, Margo; Moore, Phoebe; Tompkins, Kim

2006-01-01

Objective: Working to optimize treatment outcome and use resources efficiently, investigators conducted the first test of an existing parent-only group cognitive-behavioral therapy protocol to treat 24 children 7 to 16 years old with primary anxiety disorder diagnoses. Method: Over the course of 7 months, the authors evaluated a manual-based…

Design and fabrication of a four-man capacity urine wick evaporator system

NASA Technical Reports Server (NTRS)

1979-01-01

The integrated system was tested to determine the performance characteristics and limitations of the dual catalyst concept. The primary objective of the dual catalyst concept is to remove ammonia and other noxious substances in the gas phase and thereby eliminate the need for and current practice of chemically or electrochemically pretreating urine prior to distillation.

Loss of Word-Meaning with Spared Object Semantics in a Case of Mixed Primary Progressive Aphasia

ERIC Educational Resources Information Center

Knels, Christina; Danek, Adrian

2010-01-01

This article provides a detailed assessment of patient HT with a history of progressive language deterioration of approximately 6 years presenting now as a fluent jargon aphasic with severe impairment of both speech production and comprehension. Neuropsychological testing of non-verbal cognitive functions showed no impairment, leading to the…

Saturn Apollo Program

NASA Image and Video Library

1966-07-01

AS-203, the third Saturn IB launch vehicle developed by the Marshall Space Flight Center, lifts off from Cape Canaveral, Florida , July 5, 1966. Primary mission objectives included evaluation of the S-IVB stage's hydrogen venting and engine restart capabilities in an orbital environment. In all, nine Saturn IB flights were made, ending with the Apollo-Soyuz Test Project (ASTP) in July 1975.

Enhancing the Effectiveness of Juvenile Drug Courts by Integrating Evidence-Based Practices

ERIC Educational Resources Information Center

Henggeler, Scott W.; McCart, Michael R.; Cunningham, Phillippe B.; Chapman, Jason E.

2012-01-01

Objective: The primary purpose of this study was to test a relatively efficient strategy for enhancing the capacity of juvenile drug courts (JDC) to reduce youth substance use and criminal behavior by incorporating components of evidence-based treatments into their existing services. Method: Six JDCs were randomized to a condition in which…

A cyclic ground test of an ion auxiliary propulsion system: Description and operational considerations

NASA Technical Reports Server (NTRS)

Ling, Jerri S.; Kramer, Edward H.

1988-01-01

The Ion Auxiliary Propulsion System (IAPS) experiment is designed for launch on an Air Force Space Test Program satellite (NASA-TM-78859; AIAA Paper No. 78-647). The primary objective of the experiment is to flight qualify the 8 cm mercury ion thruster system for stationkeeping applications. Secondary objectives are measuring the interactions between operating ion thruster systems and host spacecraft, and confirming the design performance of the thruster systems. Two complete 8 cm mercury ion thruster subsystems will be flown. One of these will be operated for 2557 on and off cycles and 7057 hours at full thrust. Tests are currently under way in support of the IAPS flight experiment. In this test an IAPS thruster is being operated through a series of startup/run/shut-down cycles which simulate thruster operation during the planned flight experiment. A test facility description and operational considerations of this testing using an engineering model 8 cm thruster (S/N 905) is the subject of this paper. Final results will be published at a later date when the ground test has been concluded.

Integrated system design report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1989-07-01

The primary objective of the integrated system test phase is to demonstrate the commercial potential of a coal fueled diesel engine in its actual operating environment. The integrated system in this project is defined as a coal fueled diesel locomotive. This locomotive, shown on drawing 41D715542, is described in the separate Concept Design Report. The test locomotive will be converted from an existing oil fueled diesel locomotive in three stages, until it nearly emulates the concept locomotive. Design drawings of locomotive components (diesel engine, locomotive, flatcar, etc.) are included.

RF Modal Quantity Gaging

NASA Technical Reports Server (NTRS)

Vanleuven, K.

1989-01-01

The primary objective is to provide a concept of a radio frequency (RF) modal resonance technique which is being investigated as a method for gaging the quantities of subcritical cryogenic propellants in metallic tanks. Of special interest are the potential applications of the technique to microgravity propellant gaging situations. The results of concept testing using cryogenic oxygen, hydrogen, and nitrogen, as well as paraffin simulations of microgravity fluid orientations, are reported. These test results were positive and showed that the gaging concept was viable.

Astronomical telescope with holographic primary objective

NASA Astrophysics Data System (ADS)

Ditto, Thomas D.; Friedman, Jeffrey F.; Content, David A.

2011-09-01

A dual dispersion telescope with a plane grating primary objective was previously disclosed that can overcome intrinsic chromatic aberration of dispersive optics while allowing for unprecedented features such as million object spectroscopy, extraordinary étendue, flat primary objective with a relaxed figure tolerance, gossamer membrane substrate stowable as an unsegmented roll inside a delivery vehicle, and extensibility past 100 meter aperture at optical wavelengths. The novel design meets many criteria for space deployment. Other embodiments are suitable for airborne platforms as well as terrestrial and lunar sites. One problem with this novel telescope is that the grazing exodus configuration necessary to achieve a large aperture is traded for throughput efficiency. Now we show how the hologram of a point source used in place of the primary objective plane grating can improve efficiency by lowering the diffraction angle below grazing exodus. An intermediate refractive element is used to compensate for wavelength dependent focal lengths of the holographic primary objective.

Effect of Simvastatin on Cognitive Functioning in Children With Neurofibromatosis Type 1

PubMed Central

Krab, Lianne C.; de Goede-Bolder, Arja; Aarsen, Femke K.; Pluijm, Saskia M. F.; Bouman, Marlies J.; van der Geest, Jos N.; Lequin, Maarten; Catsman, Coriene E.; Arts, Willem Frans M.; Kushner, Steven A.; Silva, Alcino J.; de Zeeuw, Chris I.; Moll, Henriëtte A.; Elgersma, Ype

2009-01-01

Context Neurofibromatosis type 1 (NF1) is among the most common genetic disorders that cause learning disabilities. Recently, it was shown that statin-mediated inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase restores the cognitive deficits in an NF1 mouse model. Objective To determine the effect of simvastatin on neuropsychological, neurophysiological, and neuroradiological outcome measures in children with NF1. Design, Setting, and Participants Sixty-two of 114 eligible children (54%) with NF1 participated in a randomized, double-blind, placebo-controlled trial conducted between January 20, 2006, and February 8, 2007, at an NF1 referral center at a Dutch university hospital. Intervention Simvastatin or placebo treatment once daily for 12 weeks. Main Outcome Measures Primary outcomes were scores on a Rey complex figure test (delayed recall), cancellation test (speed), prism adaptation, and the mean brain apparent diffusion coefficient based on magnetic resonance imaging. Secondary outcome measures were scores on the cancellation test (standard deviation), Stroop color word test, block design, object assembly, Rey complex figure test (copy), Beery developmental test of visual-motor integration, and judgment of line orientation. Scores were corrected for baseline performance, age, and sex. Results No significant differences were observed between the simvastatin and placebo groups on any primary outcome measure: Rey complex figure test (β=0.10; 95% confidence interval [CI], −0.36 to 0.56); cancellation test (β=−0.19; 95% CI, −0.67 to 0.29); prism adaptation (odds ratio=2.0; 95% CI, 0.55 to 7.37); and mean brain apparent diffusion coefficient (β=0.06; 95% CI, −0.07 to 0.20). In the secondary outcome measures, we found a significant improvement in the simvastatin group in object assembly scores (β=0.54; 95% CI, 0.08 to 1.01), which was specifically observed in children with poor baseline performance (β =0.80; 95% CI, 0.29 to 1.30). Other secondary outcome measures revealed no significant effect of simvastatin treatment. Conclusion In this 12-week trial, simvastatin did not improve cognitive function in children with NF1. PMID:18632543

The Orexin Antagonist SB-649868 Promotes and Maintains Sleep in Men with Primary Insomnia

PubMed Central

Bettica, Paolo; Squassante, Lisa; Zamuner, Stefano; Nucci, Gianluca; Danker-Hopfe, Heidi; Ratti, Emiliangelo

2012-01-01

Study Objectives: To assess the acute effects of SB-649868 in male subjects with Primary Insomnia with regard to (1) objective and subjective sleep parameters, (2) safety and tolerability, (3) next-day residual effects. Design: Multicenter, randomized, double-blind, placebo-controlled crossover study using a complete set of Williams orthogonal Latin Squares Setting: 9 sleep centers in Germany Patients: 52 male subjects with a diagnosis of primary insomnia (difficulty in sleep initiation and maintenance) confirmed by polysomnography Interventions: SB-649868 (10, 30, 60 mg) and placebo administered after dinner 90 minutes before bedtime Measurements and Results: Sleep effects assessed by polysomnography during 2 consecutive nights and by sleep questionnaires completed by subjects after each night at the sleep laboratory. Safety and tolerability were assessed by adverse events collection, electrocardiogram (ECG), vital signs, laboratory tests. Next-day residual effects were assessed by Digit Symbol Substitution Test, and modified Verbal Learning Memory Test administered at “lights on” after night 2. SB-649868 significantly reduced latency to persistent sleep, wake after sleep onset (WASO), and increased total sleep time (TST) compared to placebo. A dose-dependent effect was observed. A dose-dependent increase in absolute and percent REM sleep and reduction in REM sleep latency was observed mainly at the 60-mg dose. SB-649868 was well tolerated with inconsistent next day residual effects. SB-649868 sleep effects were correlated with SB-649868 circulating levels. Conclusion: The data demonstrate the sleep-promoting properties of the orexin antagonist SB-649868 in male patients with insomnia. Clinical Trials Information: This study was registered on ClinicalTrials.gov with the following identifier: NCT00426816. URL: http://www.clinicaltrial.gov/ct2/show/NCT00426816?term=649868&rank=5. Citation: Bettica P; Squassante L; Zamuner S; Nucci G; Danker-Hopfe H; Ratti E. The orexin antagonist SB-649868 promotes and maintains sleep in men with primary insomnia. SLEEP 2012;35(8):1097-1104. PMID:22851805

Evaluation and Comparison of Changes in Microhardness of Primary and Permanent Enamel on Exposure to Acidic Center-filled Chewing Gum: An in vitro Study

PubMed Central

Muppa, Radhika; Srinivas, NCH; Kumar, Duddu Mahesh

2014-01-01

ABSTRACT Objectives: The study is to evaluate changes in microhardness of enamel after exposure to acidic center filled chewing gum on primary and permanent teeth. Methods: Thirty primary and 30 permanent molar extracted teeth were painted with acid resistant varnish except a small window over buccal surface. Teeth were divided into four groups according to type of teeth and type of chewing gum (Center fresh and Bubbaloo) (D1, P1, D2 and P2); each tooth was exposed to whole chewing gum mashed with 5 ml of artificial saliva for five minutes at room temperature twice a day for 5 days. After the exposure, teeth were stored in deionized water and submitted for microhardness tests. Results: Paired t-test and independent sample t-test were used for statistical analysis. A significant reduction in microhardness was found between exposed and unexposed areas in all groups. There was no statistically significant difference in reduction of microhardness to chewing gums, and between primary and permanent enamel. Conclusion: There is a definite reduction in microhardness in all groups exposed to chewing gums. Both the chewing gums are equally erosive; both permanent and primary teeth were affected. How to cite this article: Mudumba VL, Muppa R, Srinivas NCH, Kumar DM. Evaluation and Comparison of Changes in Microhardness of Primary and Permanent Enamel on Exposure to Acidic Center-filled Chewing Gum: An in vitro Study. Int J Clin Pediatr Dent 2014;7(1):24-29. PMID:25206233

Humidity effects on soluble core mechanical and thermal properties (polyvinyl alcohol/microballoon composite) type CG extendospheres, volume 2

NASA Technical Reports Server (NTRS)

1993-01-01

This document constitutes the final report for the study of humidity effects and loading rate on soluble core (PVA/MB composite material) mechanical and thermal properties under Contract No. 100345. This report describes test results procedures employed, and any unusual occurrences or specific observations associated with this test program. The primary objective of this work was to determine if cured soluble core filler material regains its tensile and compressive strength after exposure to high humidity conditions and following a drying cycle. Secondary objectives include measurements of tensile and compressive modulus, and Poisson's ratio, and coefficient of thermal expansion (CTE) for various moisture exposure states. A third objective was to compare the mechanical and thermal properties of the composite using 'SG' and 'CG' type extendospheres. The proposed facility for the manufacture of soluble cores at the Yellow Creek site incorporates no capability for the control of humidity. Recent physical property tests performed with the soluble core filler material showed that prolonged exposure to high humidity significantly degradates in strength. The purpose of these tests is to determine if the product, process or facility designs require modification to avoid imparting a high risk condition to the ASRM.

Long Duration Sorbent Testbed

NASA Technical Reports Server (NTRS)

Howard, David F.; Knox, James C.; Long, David A.; Miller, Lee; Cmaric, Gregory; Thomas, John

2016-01-01

The Long Duration Sorbent Testbed (LDST) is a flight experiment demonstration designed to expose current and future candidate carbon dioxide removal system sorbents to an actual crewed space cabin environment to assess and compare sorption working capacity degradation resulting from long term operation. An analysis of sorbent materials returned to Earth after approximately one year of operation in the International Space Station's (ISS) Carbon Dioxide Removal Assembly (CDRA) indicated as much as a 70% loss of working capacity of the silica gel desiccant material at the extreme system inlet location, with a gradient of capacity loss down the bed. The primary science objective is to assess the degradation of potential sorbents for exploration class missions and ISS upgrades when operated in a true crewed space cabin environment. A secondary objective is to compare degradation of flight test to a ground test unit with contaminant dosing to determine applicability of ground testing.

Superconducting gravity gradiometer mission. Volume 2: Study team technical report

NASA Technical Reports Server (NTRS)

Morgan, Samuel H. (Editor); Paik, Ho Jung (Editor)

1988-01-01

Scientific and engineering studies and developments performed or directed by a Study Team composed of various Federal and University activities involved with the development of a three-axis superconducting gravity gradiometer integrated with a six-axis superconducting accelerometer are examined. This instrument is being developed for a future orbital mission to make precise global gravity measurements. The scientific justification and requirements for such a mission are discussed. This includes geophysics, the primary mission objective, as well as secondary objective, such as navigation and feats of fundamental laws of physics, i.e., a null test of the inverse square law of gravitation and tests of general relativity. The instrument design and status along with mission analysis, engineering assessments, and preliminary spacecraft concepts are discussed. In addition, critical spacecraft systems and required technology advancements are examined. The mission requirements and an engineering assessment of a precursor flight test of the instrument are discussed.

Autogenic-Feedback Training for the Control of Space Motion Sickness

NASA Technical Reports Server (NTRS)

Cowings, Patricia S.; Toscano, W. B.

1994-01-01

This paper presents case-studies of 9 shuttle crewmembers (prime and alternates) and one U.S. Navy F-18 pilot, as they participated in all preflight training and testing activities in support of a life sciences flight experiment aboard Spacelab-J, and Spacelab-3. The primary objective of the flight experiment was to determine if Autogenic-feedback training (AFT), a physiological self-regulation training technique would be an effective treatment for motion sickness and space motion sickness in these crewmembers. Additional objectives of this study involved the examining human physiological responses to motion sickness on Earth and in space, as well as developing predictive criteria for susceptibility to space motion sickness based on ground-based data. Comparisons of these crewmembers are made to a larger set of subjects from previous experiments (treatment and "test-only" controls subjects). This paper describes all preflight methods, results and proposed changes for future tests.

Effects of Autonomic Conditioning on Motion Sickness Tolerance

NASA Technical Reports Server (NTRS)

Cowings, P. S.; Toscano, W. B.

1994-01-01

This paper presents case-studies of 9 shuttle crewmembers (prime and alternates) and one U.S. Navy F-18 pilot, as they participated in all preflight training and testing activities in support of a life sciences flight experiment aboard Spacelab-J, and Spacelab-3. The primary objective of the flight experiment was to determine if Autogenic-feedback training (AFT), a physiological self-regulation training technique would be an effective treatment for motion sickness and space motion sickness in these crewmembers. Additional objectives of this study involved the examining human Physiological- responses to motion sickness on Earth and in space, as well as developing predictive criteria for susceptibility to space motion sickness based on ground-based data. Comparisons of these crewmembers are made to a larger set of subjects from previous experiments (treatment and test-only controls subjects). This paper describes all preflight methods, results and proposed changes for future tests.

Robust decentralized control laws for the ACES structure

NASA Technical Reports Server (NTRS)

Collins, Emmanuel G., Jr.; Phillips, Douglas J.; Hyland, David C.

1991-01-01

Control system design for the Active Control Technique Evaluation for Spacecraft (ACES) structure at NASA Marshall Space Flight Center is discussed. The primary objective of this experiment is to design controllers that provide substantial reduction of the line-of-sight pointing errors. Satisfaction of this objective requires the controllers to attenuate beam vibration significantly. The primary method chosen for control design is the optimal projection approach for uncertain systems (OPUS). The OPUS design process allows the simultaneous tradeoff of five fundamental issues in control design: actuator sizing, sensor accuracy, controller order, robustness, and system performance. A brief description of the basic ACES configuration is given. The development of the models used for control design and control design for eight system loops that were selected by analysis of test data collected from the structure are discussed. Experimental results showing that very significant performance improvement is achieved when all eight feedback loops are closed are presented.

Perceptual expertise and top-down expectation of musical notation engages the primary visual cortex.

PubMed

Wong, Yetta Kwailing; Peng, Cynthia; Fratus, Kristyn N; Woodman, Geoffrey F; Gauthier, Isabel

2014-08-01

Most theories of visual processing propose that object recognition is achieved in higher visual cortex. However, we show that category selectivity for musical notation can be observed in the first ERP component called the C1 (measured 40-60 msec after stimulus onset) with music-reading expertise. Moreover, the C1 note selectivity was observed only when the stimulus category was blocked but not when the stimulus category was randomized. Under blocking, the C1 activity for notes predicted individual music-reading ability, and behavioral judgments of musical stimuli reflected music-reading skill. Our results challenge current theories of object recognition, indicating that the primary visual cortex can be selective for musical notation within the initial feedforward sweep of activity with perceptual expertise and with a testing context that is consistent with the expertise training, such as blocking the stimulus category for music reading.

Space station ECLSS simplified integrated test

NASA Technical Reports Server (NTRS)

Schunk, Richard G.; Bagdigian, Robert M.; Carrasquillo, Robyn L.; Ogle, Kathyrn Y.; Wieland, Paul O.

1989-01-01

A discussion of the Space Station Simplified Integrated Test (SIT) was conducted. The first in a series of three integrated Environmental Control and Life Support (ECLS) system tests, the primary objectives of the SIT were to verify proper operation of ECLS subsystems functioning in an integrated fashion as well as to gather preliminary performance data for the partial ECLS system used in the test. A description of the SIT configuration, a summary of events, a discussion of anomalies that occurred during the test, and detailed results and analysis from individual measurements and water and gas samples taken during the test are included. The preprototype ECLS hardware used in the test is reported providing an overall process description and theory of operation for each hardware item.

Solder Joint Health Monitoring Testbed

NASA Technical Reports Server (NTRS)

Delaney, Michael M.; Flynn, James; Browder, Mark

2009-01-01

A method of monitoring the health of selected solder joints, called SJ-BIST, has been developed by Ridgetop Group Inc. under a Small Business Innovative Research (SBIR) contract. The primary goal of this research program is to test and validate this method in a flight environment using realistically seeded faults in selected solder joints. An additional objective is to gather environmental data for future development of physics-based and data-driven prognostics algorithms. A test board is being designed using a Xilinx FPGA. These boards will be tested both in flight and on the ground using a shaker table and an altitude chamber.

Hubble Space Telescope NiH2 six battery test

NASA Technical Reports Server (NTRS)

Whitt, Thomas H.; Lanier, J. Roy

1991-01-01

The primary objectives of the test are: (1) to get a better understanding of the operating characteristics of the NiH2 batteries in the Hubble Space Telescope (HST) Electric Power Subsystem (EPS) by simulating every aspect of the expected operating environment; (2) to determine the optimum charge level and charge scheme for the NiH2 batteries in the HST EPS; (3) to predict the performance of the actual HST EPS; (4) to observe the aging characteristics of the batteries; and (5) to test different EPS anomalies before experiencing the anomalies on the actual HST.

LDEF mechanical systems

NASA Technical Reports Server (NTRS)

Spear, Steve; Dursch, Harry

1991-01-01

Following the Long Duration Exposure Facility (LDEF), the Systems Special Investigation Group (SIG) was involved in a considerable amount of testing of mechanical hardware flown on the LDEF. The primary objectives were to determine the effects of the long term exposure on: (1) mechanisms employed both on the LDEF or as part of individual experiments; (2) structural components; and (3) fasteners. Results of testing the following LDEF hardware are presented: LDEF structure, fasteners, trunnions, end support beam, environment exposure control cannisters, motors, and lubricants. A limited discussion of PI test results is included. The lessons learned are discussed along with the future activities of the System SIG.

Preliminary Analysis of the 30-m UltraBoom Flight Test

NASA Technical Reports Server (NTRS)

Agnes, Gregory S.; Abelson, Robert D.; Miyake, Robert; Lin, John K. H.; Welsh, Joe; Watson, Judith J.

2005-01-01

Future NASA missions require long, ultra-lightweight booms to enable solar sails, large sunshields, and other gossamer-type spacecraft structures. The space experiment discussed in this paper will flight validate the non-traditional ultra lightweight rigidizable, inflatable, isogrid structure utilizing graphite shape memory polymer (GR/SMP) called UltraBoom(TradeMark). The focus of this paper is the analysis of the 3-m ground test article. The primary objective of the mission is to show that a combination of ground testing and analysis can predict the on-orbit performance of an ultra lightweight boom that is scalable, predictable, and thermomechanically stable.

[Primary care screening of problems in the elderly and a proposal for a screening protocol with a multidimensional approach].

PubMed

Lino, Valéria Teresa Saraiva; Portela, Margareth Crisóstomo; Camacho, Luiz Antonio Bastos; Rodrigues, Nadia Cristina Pinheiro; Andrade, Monica Kramer de Noronha; O'Dwyer, Gisele

2016-07-21

The objectives were to examine psychometric properties of a screening test for the elderly and to propose a protocol for use in primary care. The method consisted of four stages: (1) inter-evaluator reliability for performance tests and self-assessment questions for eight functions; (2) sensitivity and specificity of questions on depression and social support; (3) meeting of experts to select instrumental activities of daily living (IADL); and (4) elaboration of the protocol. Screening lasted 16 minutes. Inter-evaluator reliability was excellent for performance tests but poor for questions. Depression and social support showed satisfactory sensitivity and specificity (0.74/0.77 and 0.77/0.96). Four IADL were selected by more than 55% of the experts. Following the results, a screening protocol was elaborated that prioritized the use of performance tests, maintaining questions on mood, social support, and IADL. The study suggests better reproducibility of performance tests when compared to questions. For mood and social support, the questions may provide a first screening stage. The proposed protocol allows rapid screening of problems.

Aerodynamic results of a support system interference effects test conducted at NASA/LaRC UPWT using an 0.015-scale model of the configuration 140A/B SSV orbiter (0A20B)

NASA Technical Reports Server (NTRS)

Campbell, J. H., II; Embury, W. R.

1974-01-01

An experimental aerodynamic investigation was conducted to determine the interference effects of a wind tunnel support system. The test article was a 0.015 scale model of the space shuttle orbiter. The primary objective of the test was to determine the extent that aerodynamic simulation of the space shuttle orbiter is affected by base mounting the model, without nozzles, on a straight sting. Two support systems were tested. The characteristics of the support systems are described. Data from the tests are presented in the form of graphs and tables.

Control and Non-Payload Communications (CNPC) Prototype Radio - Generation 2 Flight Test Report

NASA Technical Reports Server (NTRS)

Ishac, Joseph A.; Iannicca, Dennis C.; Shalkhauser, Kurt A.; Kachmar, Brian A.

2014-01-01

NASA Glenn Research Center conducted a series of flight tests for the purpose of evaluating air-to-ground communications links for future unmanned aircraft systems (UAS). The primary objective of the test effort was to evaluate the transition of the aircraft communications from one ground station to the next, and to monitor data flow during the "hand-off" event. To facilitate the testing, ground stations were installed at locations in Cleveland, Ohio and Albany, Ohio that each provides line-of-sight radio communications with an overflying aircraft. This report describes results from the flight tests including flight parameters, received signal strength measurements, data latency times, and performance observations for the air-to-ground channel.

Composite propulsion feedlines for cryogenic space vehicles, volume 1

NASA Technical Reports Server (NTRS)

Hall, C. A.; Laintz, D. J.; Phillips, J. M.

1973-01-01

Thin metallic liners that provide leak-free service in cryogenic propulsion systems are overwrapped with a glass-fiber composite that provides strength and protection from handling damage. The resultant tube is lightweight, strong and has a very low thermal flux. Several styles of tubing ranging from 5 to 38 cm in diameter and up to 305 cm long were fabricated and tested at operating temperatures from 294 to 21 K and operating pressures up to 259 N/sq cm. The primary objective for the smaller sizes was thermal performance optimization of the propulsion system while the primary objective of the larger sizes was weight optimization and to prove fabricability. All major program objectives were met resulting in a design concept that is adaptable to a wide range of aerospace vehicle requirements. Major items of development included: bonding large diameter aluminum end fittings to the thin Inconel liner; fabrication of a 38 cm diameter tube from 0.008 cm thick Inconel; and evaluation of tubing which provides essentially zero quality propellant in a very short period of time resulting in a lower mass of propellant expended in chilldown.

Patterns of cancer screening in primary care from 2005 to 2010.

PubMed

Martires, Kathryn J; Kurlander, David E; Minwell, Gregory J; Dahms, Eric B; Bordeaux, Jeremy S

2014-01-15

Cancer screening recommendations vary widely, especially for breast, prostate, and skin cancer screening. Guidelines are provided by the American Cancer Society, the US Preventive Services Task Force, and various professional organizations. The recommendations often differ with regard to age and frequency of screening. The objective of this study was to determine actual rates of screening in the primary care setting. Data from the National Ambulatory Medical Care Survey were used. Only adult visits to non-federally employed, office-based physicians for preventive care from 2005 through 2010 were examined. Prevalence rates for breast, pelvic, and rectal examinations were calculated, along with the rates for mammograms, Papanicolaou smears, and prostate-specific antigen tests. Factors associated with screening, including age, race, smoking status, and insurance type, were examined using t tests and chi-square tests. In total, 8521 visits were examined. The rates of most screening examinations and tests were stable over time. Clinical breast examinations took place significantly more than mammography was ordered (54.8% vs 34.6%; P<.001). White patients received more mammography (P=.031), skin examinations (P<.010), digital rectal examinations (P<.010), and prostate-specific antigen tests (P=.003) than patients of other races. Patients who paid with Medicare or private insurance received more screening than patients who had Medicaid or no insurance (P<.010). Current cancer screening practices in primary care vary significantly. Cancer screening may not follow evidence-based practices and may not be targeting patients considered most at risk. Racial and socioeconomic disparities are present in cancer screening in primary care. © 2013 American Cancer Society.

Performance characterization of active fiber-composite actuators for helicopter rotor blade applications

NASA Astrophysics Data System (ADS)

Wickramasinghe, Viresh K.; Hagood, Nesbitt W.

2002-07-01

The primary objective of this work was to characterize the performance of the Active Fiber Composite (AFC) actuator material system for the Boeing Active Material Rotor (AMR) blade application. The AFCs were a new structural actuator system consisting of piezoceramic fibers embedded in an epoxy matrix and sandwiched between interdigitated electrodes to orient the driving electric field in the fiber direction to use the primary piezoelectric effect. These actuators were integrated directly into the blade spar laminate as active plies within the composite structure to perform structural actuation for vibration control in helicopters. Therefore, it was necessary to conduct extensive electromechanical material characterization to evaluate AFCs both as actuators and as structural components of the rotor blade. The characterization tests designed to extract important electromechanical properties under simulated blade operating conditions included stress-strain tests, free strain tests and actuation under tensile load tests. This paper presents the test results as well as the comprehensive testing process developed to evaluate the relevant AFC material properties. The results from this comprehensive performance characterization of the AFC material system supported the design and operation of the Boeing AMR blade scheduled for hover and forward flight wind tunnel tests.

Skin test reactivity to female sex hormones in women with primary unexplained recurrent pregnancy loss.

PubMed

Ellaithy, Mohamed I; Fathi, Hesham M; Farres, Mohamed N; Taha, Marwa S

2013-09-01

The objective was to examine the hypothesis that primary unexplained recurrent pregnancy loss might be associated with an inappropriate immunologically mediated response to progesterone and/or estrogen. This prospective study included 47 women with two or more documented consecutive early pregnancy losses of unknown etiology, and no previous history of deliveries. Intradermal skin testing was performed in the luteal phase of the cycle (days 16-20) using estradiol benzoate, progesterone, and a placebo of refined sesame oil. Immediate (20 min) and late (24h and 1 week) skin test readings for all cases were compared with those of 12 parous women of comparable age with no history of spontaneous miscarriages, premenstrual disorders, pregnancy, or sex hormone-related allergic or autoimmune diseases. Main outcome measure was skin test reactivity to estradiol and/or progesterone. Immediate skin test reactivity to both hormones was observed among half of the cases at 20 min. A papule after 24h, which persisted for up to 1 week, was observed among 32 (68.1%) and 34 (72.3%) cases at the sites of estrogen and progesterone injection, respectively. 55.3% of cases had combined skin test reactivity to both estradiol and progesterone at 1 week. All women in the control group showed absence of skin test reactivity for both estradiol and progesterone at 20 min, 24h, and 1 week. None of the subjects in either group showed skin test reactivity to placebo. There is an association between primary unexplained recurrent pregnancy loss and skin test reactivity to female sex hormones. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Characterization, performance, and prediction of a lead-acid battery under simulated electric vehicle driving requirements

NASA Technical Reports Server (NTRS)

Ewashinka, J. G.; Bozek, J. M.

1981-01-01

A state-of-the-art 6-V battery module in current use by the electric vehicle industry was tested at the NASA Lewis Research Center to determine its performance characteristics under the SAE J227a driving schedules B, C, and D. The primary objective of the tests was to determine the effects of periods of recuperation and long and short periods of electrical regeneration in improving the performance of the battery module and hence extendng the vehicle range. A secondary objective was to formulate a computer program that would predict the performance of this battery module for the above driving schedules. The results show excellent correlation between the laboratory tests and predicted results. The predicted performance compared with laboratory tests was within +2.4 to -3.7 percent for the D schedule, +0.5 to -7.1 percent for the C schedule, and better than -11.4 percent for the B schedule.

Characterization, performance, and prediction of a lead-acid battery under simulated electric vehicle driving requirements

NASA Astrophysics Data System (ADS)

Ewashinka, J. G.; Bozek, J. M.

1981-05-01

A state-of-the-art 6-V battery module in current use by the electric vehicle industry was tested at the NASA Lewis Research Center to determine its performance characteristics under the SAE J227a driving schedules B, C, and D. The primary objective of the tests was to determine the effects of periods of recuperation and long and short periods of electrical regeneration in improving the performance of the battery module and hence extendng the vehicle range. A secondary objective was to formulate a computer program that would predict the performance of this battery module for the above driving schedules. The results show excellent correlation between the laboratory tests and predicted results. The predicted performance compared with laboratory tests was within +2.4 to -3.7 percent for the D schedule, +0.5 to -7.1 percent for the C schedule, and better than -11.4 percent for the B schedule.

Evaluation of Erosion Potential of Estuarine Sediments in NY/NJ Harbor (Impact of In-Situ Stabilization on the Remediation of Soft Sediments - A preamble to Erosion Testing and Evaluation)

DOT National Transportation Integrated Search

2011-09-01

The primary objective of the project are to perform a review of existing in-situ techniques of sediment erosion potential evaluation in contaminated "superfund" sites in the United States and those from Europe and Japan and the applicability of soft ...

National Testing of Pupils in Europe: Objectives, Organisation and Use of Results. Sweden 2009

ERIC Educational Resources Information Center

Ericsson, Ann Carlson

2008-01-01

The Swedish school system comprises: (1) Pre-primary school (Forskola), typical age 1-5; (2) Preschool class in the compulsory school (Grundskola) typical age 6 (participation voluntary); (3) Compulsory school, typical age 7-16, grades 1-9, and (4) Upper secondary school, 17 programmes (4 mainly academic, 13 vocational), typical age 16-19, grades…

NASA DOD Lead Free Electronics Project

NASA Technical Reports Server (NTRS)

Kessel, Kurt R.

2008-01-01

The primary'technical objective of this project is to undertake comprehensive testing to generate information on failure modes/criteria to better understand the reliability of: Packages (e.g., Thin Small Outline Package [TSOP], Ball Grid Array [BGA], Plastic Dual In-line Package [PDIPD assembled and reworked with lead-free alloys Packages (e.g., TSOP, BGA, PDIP) assembled and reworked with mixed (lead/lead-free) alloys.

National Testing of Pupils in Europe: Objectives, Organisation and Use of Results. Lithuania 2009

ERIC Educational Resources Information Center

Bigeliene, Daiva; Gudynas, Pranas; Ranonyte, Asta; Uginciene, Egle

2009-01-01

The guiding principles of assessment policy and practice in Lithuania are described in the Law on Education (2003), General Curriculum and Educational Standards for Pre-school, Primary and Basic education (2003) and General Education Plans (2008-2009) as well as the special policy document on assessment called The Concept of Assessment of Pupils'…

Saturn Apollo Program

NASA Image and Video Library

1966-08-01

AS-202, the second Saturn IB launch vehicle developed by the Marshall Space Flight Center, lifts off from Cape Canaveral, Florida, August 25, 1966. Primary mission objectives included the confirmation of projected launch loads, demonstration of spacecraft component separation, and verification of heat shield adequacy at high reentry rates. In all, nine Saturn IB flights were made, ending with the Apollo-Soyuz Test Project (ASTP) in July 1975.

Primary care models for treating opioid use disorders: What actually works? A systematic review

PubMed Central

Klasa, Katarzyna; Bush, Christopher; Heisler, Michele; Chopra, Vineet; Bohnert, Amy

2017-01-01

Background Primary care-based models for Medication-Assisted Treatment (MAT) have been shown to reduce mortality for Opioid Use Disorder (OUD) and have equivalent efficacy to MAT in specialty substance treatment facilities. Objective The objective of this study is to systematically analyze current evidence-based, primary care OUD MAT interventions and identify program structures and processes associated with improved patient outcomes in order to guide future policy and implementation in primary care settings. Data sources PubMed, EMBASE, CINAHL, and PsychInfo. Methods We included randomized controlled or quasi experimental trials and observational studies evaluating OUD treatment in primary care settings treating adult patient populations and assessed structural domains using an established systems engineering framework. Results We included 35 interventions (10 RCTs and 25 quasi-experimental interventions) that all tested MAT, buprenorphine or methadone, in primary care settings across 8 countries. Most included interventions used joint multi-disciplinary (specialty addiction services combined with primary care) and coordinated care by physician and non-physician provider delivery models to provide MAT. Despite large variability in reported patient outcomes, processes, and tasks/tools used, similar key design factors arose among successful programs including integrated clinical teams with support staff who were often advanced practice clinicians (nurses and pharmacists) as clinical care managers, incorporating patient “agreements,” and using home inductions to make treatment more convenient for patients and providers. Conclusions The findings suggest that multidisciplinary and coordinated care delivery models are an effective strategy to implement OUD treatment and increase MAT access in primary care, but research directly comparing specific structures and processes of care models is still needed. PMID:29040331

Are we under-utilizing the talents of primary care personnel? A job analytic examination

PubMed Central

Hysong, Sylvia J; Best, Richard G; Moore, Frank I

2007-01-01

Background Primary care staffing decisions are often made unsystematically, potentially leading to increased costs, dissatisfaction, turnover, and reduced quality of care. This article aims to (1) catalogue the domain of primary care tasks, (2) explore the complexity associated with these tasks, and (3) examine how tasks performed by different job titles differ in function and complexity, using Functional Job Analysis to develop a new tool for making evidence-based staffing decisions. Methods Seventy-seven primary care personnel from six US Department of Veterans Affairs (VA) Medical Centers, representing six job titles, participated in two-day focus groups to generate 243 unique task statements describing the content of VA primary care. Certified job analysts rated tasks on ten dimensions representing task complexity, skills, autonomy, and error consequence. Two hundred and twenty-four primary care personnel from the same clinics then completed a survey indicating whether they performed each task. Tasks were catalogued using an adaptation of an existing classification scheme; complexity differences were tested via analysis of variance. Results Objective one: Task statements were categorized into four functions: service delivery (65%), administrative duties (15%), logistic support (9%), and workforce management (11%). Objective two: Consistent with expectations, 80% of tasks received ratings at or below the mid-scale value on all ten scales. Objective three: Service delivery and workforce management tasks received higher ratings on eight of ten scales (multiple functional complexity dimensions, autonomy, human error consequence) than administrative and logistic support tasks. Similarly, tasks performed by more highly trained job titles received higher ratings on six of ten scales than tasks performed by lower trained job titles. Contrary to expectations, the distribution of tasks across functions did not significantly vary by job title. Conclusion Primary care personnel are not being utilized to the extent of their training; most personnel perform many tasks that could reasonably be performed by personnel with less training. Primary care clinics should use evidence-based information to optimize job-person fit, adjusting clinic staff mix and allocation of work across staff to enhance efficiency and effectiveness. PMID:17397534

Evaluation of anxiety and depression prevalence in patients with primary severe hyperhidrosis*

PubMed Central

Bragança, Gleide Maria Gatto; Lima, Sonia Oliveira; Pinto, Aloisio Ferreira; Marques, Lucas Menezes; de Melo, Enaldo Vieira; Reis, Francisco Prado

2014-01-01

BACKGROUND Primary hyperhidrosis (PH) can lead to mood changes due to the inconveniences it causes. OBJECTIVE This study aimed to examine the existence of anxiety and depression in patients with severe primary hyperhidrosis who sought treatment at a medical office. METHODS The questionnaire "Hospital Anxiety and Depression Scale" was used for 197 individuals, in addition to the chi square test and Fisher exact test, p <0.05. RESULTS There was an increased prevalence of anxiety (49.6%) but not of depression (11.2%) among patients with PH, with no link to gender, age or amount of affected areas. Palmar and plantar primary hyperhidrosis were the most frequent but when associated with the presence of anxiety, the most frequent were the axillary (p = 0.02) and craniofacial (p = 0.02) forms. There was an association between patients with depression and anxiety (p = 0.001). CONCLUSIONS the involvement of Primary hyperhidrosis was responsible for a higher prevalence of anxiety than that described among the general population and patients with other chronic diseases. Depression had a low prevalence rate, while mild and moderate forms were the most common and frequently associated with anxiety. The degree of anxiety was higher in mild and moderate types than in the severe form. PMID:24770497

Fixation preference test: reliability for the detection of amblyopia in patients with strabismus and interexaminer agreement.

PubMed

Erkan Turan, Kadriye; Taylan Sekeroglu, Hande; Karahan, Sevilay; Sanac, Ali Sefik

2017-12-01

The purpose of this study was to analyze the reliability of the fixation preference test (FPT) in the detection of amblyopia, and to determine interexaminer agreement. Eighty patients whose visual acuity could be tested objectively and had a horizontal misalignment of more than 10 prism diopters were enrolled. The best corrected visual acuity (BCVA) and orthoptic findings were all recorded. Non-preferred eye in primary position and fixation preference grade were assessed independently by two masked experienced examiners. The primary outcome measures were reliability of FPT in terms of its correlation with BCVA and interexaminer agreement. There was no significant correlation between fixation preference grades and interocular visual acuity difference as well as the type and amount of deviation, the presence of fusion, stereopsis, anisometropia, and previous strabismus surgery for none of the examiners (p > 0.05 for all). Sensitivity was 52.0% for examiner 1 and 54.0% for examiner 2 while specificity was 50.0 and 46.7%, respectively. Interexaminer agreement was 76.7% (p < 0.001) for all patients. FPT is widely used in children particularly when the visual acuity cannot be determined in an objective manner. The test may not be accurate and reliable in the detection of amblyopia and also in predicting the visual acuity difference between both eyes, even though it was found to show a high degree of agreement between examiners. In conclusion, it should be kept in mind that the reliability of FPT may be limited and the results should be interpreted with caution and be supported by other tests.

Neural correlates of working memory performance in primary insomnia.

PubMed

Drummond, Sean P A; Walker, Matthew; Almklov, Erin; Campos, Manuel; Anderson, Dane E; Straus, Laura D

2013-09-01

To examine neural correlates of working memory performance in patients with primary insomnia (PIs) compared with well-matched good sleepers (GSs). Twenty-five PIs and 25 GSs underwent functional MRI while performing an N-back working memory task. VA hospital sleep laboratory and University-based functional imaging center. 25 PIs, 25 GSs. N/A. Although PIs did not differ from GSs in cognitive performance, PIs showed the expected differences from GSs in both self-reported and objective sleep measures. PIs, relative to GSs, showed reduced activation of task-related working memory regions. This manifested both as an overall reduction in activation of task-related regions and specifically as reduced modulation of right dorsolateral prefrontal cortex with increasing task difficulty. Similarly, PIs showed reduced modulation (i.e., reduced deactivation) of default mode regions with increasing task difficulty, relative to GSs. However, PIs showed intact performance. These data establish a profile of abnormal neural function in primary insomnia, reflected both in reduced engagement of task-appropriate brain regions and an inability to modulate task-irrelevant (i.e., default mode) brain areas during working memory performance. These data have implications for better understanding the neuropathophysiology of the well established, yet little understood, discrepancy between ubiquitous subjective cognitive complaints in primary insomnia and the rarely found objective deficits during testing.

Free-free and fixed base modal survey tests of the Space Station Common Module Prototype

NASA Technical Reports Server (NTRS)

Driskill, T. C.; Anderson, J. B.; Coleman, A. D.

1992-01-01

This paper describes the testing aspects and the problems encountered during the free-free and fixed base modal surveys completed on the original Space Station Common Module Prototype (CMP). The CMP is a 40-ft long by 14.5-ft diameter 'waffle-grid' cylinder built by the Boeing Company and housed at the Marshall Space Flight Center (MSFC) near Huntsville, AL. The CMP modal survey tests were conducted at MSFC by the Dynamics Test Branch. The free-free modal survey tests (June '90 to Sept. '90) included interface verification tests (IFVT), often referred to as impedance measurements, mass-additive testing and linearity studies. The fixed base modal survey tests (Feb. '91 to April '91), including linearity studies, were conducted in a fixture designed to constrain the CMP in 7 total degrees-of-freedom at five trunnion interfaces (two primary, two secondary, and the keel). The fixture also incorporated an airbag off-load system designed to alleviate the non-linear effects of friction in the primary and secondary trunnion interfaces. Numerous test configurations were performed with the objective of providing a modal data base for evaluating the various testing methodologies to verify dynamic finite element models used for input to coupled load analysis.

High Working Memory Load Increases Intracortical Inhibition in Primary Motor Cortex and Diminishes the Motor Affordance Effect.

PubMed

Freeman, Scott M; Itthipuripat, Sirawaj; Aron, Adam R

2016-05-18

Motor affordances occur when the visual properties of an object elicit behaviorally relevant motor representations. Typically, motor affordances only produce subtle effects on response time or on motor activity indexed by neuroimaging/neuroelectrophysiology, but sometimes they can trigger action itself. This is apparent in "utilization behavior," where individuals with frontal cortex damage inappropriately grasp affording objects. This raises the possibility that, in healthy-functioning individuals, frontal cortex helps ensure that irrelevant affordance provocations remain below the threshold for actual movement. In Experiment 1, we tested this "frontal control" hypothesis by "loading" the frontal cortex with an effortful working memory (WM) task (which ostensibly consumes frontal resources) and examined whether this increased EEG measures of motor affordances to irrelevant affording objects. Under low WM load, there were typical motor affordance signatures: an event-related desynchronization in the mu frequency and an increased P300 amplitude for affording (vs nonaffording) objects over centroparietal electrodes. Contrary to our prediction, however, these affordance measures were diminished under high WM load. In Experiment 2, we tested competing mechanisms responsible for the diminished affordance in Experiment 1. We used paired-pulse transcranial magnetic stimulation over primary motor cortex to measure long-interval cortical inhibition. We found greater long-interval cortical inhibition for high versus low load both before and after the affording object, suggesting that a tonic inhibition state in primary motor cortex could prevent the affordance from provoking the motor system. Overall, our results suggest that a high WM load "sets" the motor system into a suppressed state that mitigates motor affordances. Is an irrelevant motor affordance more likely to be triggered when you are under low or high cognitive load? We examined this using physiological measures of the motor affordance while working memory load was varied. We observed a typical motor affordance signature when working memory load was low; however, it was abolished when load was high. Further, there was increased intracortical inhibition in primary motor cortex under high working memory load. This suggests that being in a state of high cognitive load "sets" the motor system to be imperturbable to distracting motor influences. This makes a novel link between working memory load and the balance of excitatory/inhibitory activity in the motor cortex and potentially has implications for disorders of impulsivity. Copyright © 2016 the authors 0270-6474/16/365544-12$15.00/0.

General Practitioners' Clinical Impression in the Screening for Frailty: Data From the FAP Study Pilot.

PubMed

Fougère, Bertrand; Sirois, Marie-Josée; Carmichael, Pierre-Hugues; Batomen-Kuimi, Brice-Lionel; Chicoulaa, Bruno; Escourrou, Emile; Nourhashémi, Fati; Oustric, Stéphane; Vellas, Bruno

2017-02-01

The progression of frailty is marked by an increased risk of adverse health outcomes in the elderly including falls, physical and/or cognitive disability, hospitalizations, and mortality. In primary care, the general practitioner's (GP's) clinical impression about their elderly patients' frailty state seems to be a key point in identifying frail individuals in their clinical practice. The aim of this article is to examine if GPs' clinical impressions regarding frailty concurs with objective measures of the gold standard frailty phenotype as described by Fried in community-dwelling older persons. Cross-sectional study in 14 primary care GP offices in the Toulouse area from May 1st to October 31st, 2015. Fourteen GPs screened their patients ≥70 years old. GPs' "frailty impression" was based on the Gérontopôle Frailty Screening Tool. "Objective measures of the five Fried frailty criteria" were obtained by a geriatric nurse through standardized testing. The capacity of the GPs' clinical impression to detect participants objectively measured as frail was examined with diagnostic values of observed sensitivity (Se), specificity (Sp), positive predictive value (PPV), and negative predictive value (NPV). A total of 268 participants were screened by GPs and assessed by a nurse. Mean age was 81 years and 62.3% were female. According to the objective measures of Fried's criteria, frailty (three to five criteria) and pre-frailty (one to two criteria) states were identified in 31% and 45.2% of participants, respectively. The Se of the GPs' impression was good (80.39%; 95% confidence interval [CI], 74.27%-85.61%), and the Sp was moderate (64.06%; 95% CI, 5.10%-75.68%). The overall PPV of the GPs' impression was 87.70% (95% CI, 82.12%-92.04%), and the NPV was 50.51% (95% CI, 39.27%-61.91%). Although the PPV increased with age reaching 93.33% (95% CI, 85.12%-97.80%) among patients ≥ 85 years old, the NPV decreased accordingly to a minimal 21.43% (95% CI, 4.66%-50.80%) in that subgroup. The present study highlights the importance of the GPs' clinical impression on frailty as a fair means to identify this syndrome in community-dwelling older patients in primary care. This clinical impression may not be sufficient, however, and some objective tests could be added to improve the accuracy of frailty detection in older patients in primary care. Copyright © 2016 AMDA – The Society for Post-Acute and Long-Term Care Medicine. Published by Elsevier Inc. All rights reserved.

LUTE primary mirror materials and design study report

NASA Astrophysics Data System (ADS)

Ruthven, Greg

1993-02-01

The major objective of the Lunar Ultraviolet Telescope Experiment (LUTE) Primary Mirror Materials and Design Study is to investigate the feasibility of the LUTE telescope primary mirror. A systematic approach to accomplish this key goal was taken by first understanding the optical, thermal, and structural requirements and then deriving the critical primary mirror-level requirements for ground testing, launch, and lunar operations. After summarizing the results in those requirements which drove the selection of material and the design for the primary mirror are discussed. Most important of these are the optical design which was assumed to be the MSFC baseline (i.e. 3 mirror optical system), telescope wavefront error (WFE) allocations, the telescope weight budget, and the LUTE operational temperature ranges. Mechanical load levels, reflectance and microroughness issues, and options for the LUTE metering structure were discussed and an outline for the LUTE telescope sub-system design specification was initiated. The primary mirror analysis and results are presented. The six material substrate candidates are discussed and four distinct mirror geometries which are considered are shown. With these materials and configurations together with varying the location of the mirror support points, a total of 42 possible primary mirror designs resulted. The polishability of each substrate candidate was investigated and a usage history of 0.5 meter and larger precision cryogenic mirrors (the operational low end LUTE temperature of 60 K is the reason we feel a survey of cryogenic mirrors is appropriate) that were flown or tested are presented.

LUTE primary mirror materials and design study report

NASA Technical Reports Server (NTRS)

Ruthven, Greg

1993-01-01

The major objective of the Lunar Ultraviolet Telescope Experiment (LUTE) Primary Mirror Materials and Design Study is to investigate the feasibility of the LUTE telescope primary mirror. A systematic approach to accomplish this key goal was taken by first understanding the optical, thermal, and structural requirements and then deriving the critical primary mirror-level requirements for ground testing, launch, and lunar operations. After summarizing the results in those requirements which drove the selection of material and the design for the primary mirror are discussed. Most important of these are the optical design which was assumed to be the MSFC baseline (i.e. 3 mirror optical system), telescope wavefront error (WFE) allocations, the telescope weight budget, and the LUTE operational temperature ranges. Mechanical load levels, reflectance and microroughness issues, and options for the LUTE metering structure were discussed and an outline for the LUTE telescope sub-system design specification was initiated. The primary mirror analysis and results are presented. The six material substrate candidates are discussed and four distinct mirror geometries which are considered are shown. With these materials and configurations together with varying the location of the mirror support points, a total of 42 possible primary mirror designs resulted. The polishability of each substrate candidate was investigated and a usage history of 0.5 meter and larger precision cryogenic mirrors (the operational low end LUTE temperature of 60 K is the reason we feel a survey of cryogenic mirrors is appropriate) that were flown or tested are presented.

Hanford’s Supplemental Treatment Project: Full-Scale Integrated Testing of In-Container-Vitrification and a 10,000-Liter Dryer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Witwer, Keith S.; Dysland, Eric J.; Garfield, J. S.

2008-02-22

The GeoMelt® In-Container Vitrification™ (ICV™) process was selected by the U.S. Department of Energy (DOE) in 2004 for further evaluation as the supplemental treatment technology for Hanford’s low-activity waste (LAW). Also referred to as “bulk vitrification,” this process combines glass forming minerals, LAW, and chemical amendments; dries the mixture; and then vitrifies the material in a refractory-lined steel container. AMEC Nuclear Ltd. (AMEC) is adapting its GeoMelt ICV™ technology for this application with technical and analytical support from Pacific Northwest National Laboratory (PNNL). The DVBS project is funded by the DOE Office of River Protection and administered by CH2M HILLmore » Hanford Group, Inc. The Demonstration Bulk Vitrification Project (DBVS) was initiated to engineer, construct, and operate a full-scale bulk vitrification pilot-plant to treat up to 750,000 liters of LAW from Waste Tank 241-S-109 at the DOE Hanford Site. Since the beginning of the DBVS project in 2004, testing has used laboratory, crucible-scale, and engineering-scale equipment to help establish process limitations of selected glass formulations and identify operational issues. Full-scale testing has provided critical design verification of the ICV™ process before operating the Hanford pilot-plant. In 2007, the project’s fifth full-scale test, called FS-38D, (also known as the Integrated Dryer Melter Test, or IDMT,) was performed. This test had three primary objectives: 1) Demonstrate the simultaneous and integrated operation of the ICV™ melter with a 10,000-liter dryer, 2) Demonstrate the effectiveness of a new feed reformulation and change in process methodology towards reducing the production and migration of molten ionic salts (MIS), and, 3) Demonstrate that an acceptable glass product is produced under these conditions. Testing was performed from August 8 to 17, 2007. Process and analytical results demonstrated that the primary test objectives, along with a dozen supporting objectives, were successfully met. Glass performance exceeded all disposal performance criteria. A previous issue with MIS containment was successfully resolved in FS-38D, and the ICV™ melter was integrated with a full-scale, 10,000-liter dryer. This paper describes the rationale for performing the test, the purpose and outcome of scale-up tests preceding it, and the performance and outcome of FS-38D.« less

Genetic education for primary care providers

PubMed Central

Carroll, June C.; Rideout, Andrea L.; Wilson, Brenda J.; Allanson, Judith MD; Blaine, Sean M.; Esplen, Mary Jane; Farrell, Sandra A.; Graham, Gail E.; MacKenzie, Jennifer; Meschino, Wendy; Miller, Fiona; Prakash, Preeti; Shuman, Cheryl; Summers, Anne; Taylor, Sherry

2009-01-01

ABSTRACT OBJECTIVE To increase primary care providers’ awareness and use of genetic services; increase their knowledge of genetic issues; increase their confidence in core genetic competencies; change their attitudes toward genetic testing for hereditary diseases; and increase their confidence as primary care genetic resources. DESIGN Participants completed a workshop and 3 questionnaires: a baseline questionnaire, a survey that provided immediate feedback on the workshop itself, and a follow-up questionnaire 6 months later. SETTING Ontario. PARTICIPANTS Primary care providers suggested by deans of nursing, midwifery, family medicine, and obstetric programs, as well as coordinators of nurse practitioner programs, in Ontario and by the Ontario College of Family Physicians. INTERVENTION A complex educational intervention was developed, including an interactive workshop and PowerPoint educational modules on genetic topics for participants’ use (available at www.mtsinai.on.ca/FamMedGen/). MAIN OUTCOME MEASURES Awareness and use of genetic services, knowledge of genetics, confidence in core clinical genetic skills, attitudes toward genetic testing, and teaching activities related to genetics. RESULTS The workshop was attended by 29 participants; of those, 21 completed the baseline questionnaire and the 6-month follow-up questionnaire. There was no significant change found in awareness or reported use of genetic services. There was significant improvement in self-assessed knowledge of (P = .001) and confidence in (P = .005) skills related to adult-onset genetic disorders. There were significant increases in confidence in many core genetic competencies, including assessing risk of hereditary disorders (P = .033), deciding who should be offered referral for genetic counseling (P = .003), discussing prenatal testing options (P = .034), discussing benefits, risks, and limitations of genetic testing (P = .033), and describing what to expect at a genetic counseling session (P = .022). There was a significant increase in the number of primary care providers agreeing that genetic testing was beneficial in the management of adult-onset diseases (P = .031) and in their confidence in being primary care genetic resources for adult-onset genetic disorders (P = .006). CONCLUSION Educational interventions that include interactive peer resource workshops and educational modules can increase knowledge of and confidence in the core competencies needed for the delivery of genetic services in primary care. PMID:20008584

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weiland, Mark A.; Ploskey, Gene R.; Hughes, James S.

The overall purpose of the acoustic telemetry study at JDA during 2009 was to determine the best configuration and operation for JDA prior to conducting BiOp performance standard tests. The primary objective was to determine the best operation between 30% and 40% spill treatments. Route-specific and JDA to TDA forebay survival estimates, passage distribution, and timing/behavior metrics were used for comparison of 30% to a 40% spill treatments. A secondary objective was to evaluate the performance of TSWs installed in spill bays 15 and 16 and to estimate fish survival rates and passage efficiencies under 30% and 40% spill-discharge treatmentsmore » each season.« less

Impact of Oral Health Education on Oral Health Knowledge of Private School Children in Riyadh City, Saudi Arabia

PubMed Central

Al Saffan, Abdulrahman Dahham; Baseer, Mohammad Abdul; Alshammary, Abdul Aziz; Assery, Mansour; Kamel, Ashraf; Rahman, Ghousia

2017-01-01

Aims and Objectives: To assess the early effect of oral health education on oral health knowledge of primary and intermediate school students of private schools by utilizing pre/post questionnaires data from oral health educational projects in Riyadh city, Saudi Arabia. Second, to examine topic-specific knowledge differences between genders, nationalities, and educational levels of the students. Materials and Methods: Cross-sectional oral health educational data of private school students (n = 1279) in primary and intermediate levels were extracted from the King Salman Centre for Children's Health (KSCCH) projects undertaken by Riyadh Colleges of Dentistry and Pharmacy. Student's pre- and post-test data were analyzed for changes in oral health knowledge. Overall knowledge score and topic-specific knowledge scores were calculated and the differences between gender, nationality, and educational level were examined using Mann–Whitney U-test. Pre/post change in the oral health knowledge was evaluated by Wilcoxon's sign rank test. Results: Immediately, after oral health educational session high knowledge score category showed an increase of 25.6%, medium and low knowledge score categories showed −3.2% and −22.3% decrease, and this change was statistically significant (P < 0.001). Comparison of correct responses between pre- and post-test showed statistically significant (P < 0.05) increase in all the questions except for the timing of tooth brushing. Females, non-Saudi nationals and students in primary level of education showed significantly high mean knowledge (P < 0.001) at posttest assessment. Conclusion: Primary and intermediate private school student's overall, and topic-specific oral health knowledge improved immediately after educational intervention provided by KSCCH. High knowledge gain was observed among female non-Saudi primary school students. PMID:29285475

A Predictive Algorithm to Detect Opioid Use Disorder: What Is the Utility in a Primary Care Setting?

PubMed

Lee, Chee; Sharma, Maneesh; Kantorovich, Svetlana; Brenton, Ashley

2018-01-01

The purpose of this study was to determine the clinical utility of an algorithm-based decision tool designed to assess risk associated with opioid use in the primary care setting. A prospective, longitudinal study was conducted to assess the utility of precision medicine testing in 1822 patients across 18 family medicine/primary care clinics in the United States. Using the profile, patients were categorized into low, moderate, and high risk for opioid use. Physicians who ordered testing were asked to complete patient evaluations and document their actions, decisions, and perceptions regarding the utility of the precision medicine tests. Approximately 47% of primary care physicians surveyed used the profile to guide clinical decision-making. These physicians rated the benefit of the profile on patient care an average of 3.6 on a 5-point scale (1 indicating no benefit and 5 indicating significant benefit). Eighty-eight percent of all clinicians surveyed felt the test exhibited some benefit to their patient care. The most frequent utilization for the profile was to guide a change in opioid prescribed. Physicians reported greater benefit of profile utilization for minority patients. Patients whose treatment was guided by the profile had pain levels that were reduced, on average, 2.7 levels on the numeric rating scale. The profile provided primary care physicians with a useful tool to stratify the risk of opioid use disorder and was rated as beneficial for decision-making and patient improvement by the majority of physicians surveyed. Physicians reported the profile resulted in greater clinical improvement for minorities, highlighting the objective use of this profile to guide judicial use of opioids in high-risk patients. Significantly, when physicians used the profile to guide treatment decisions, patient-reported pain was greatly reduced.

Two color holographic interferometry for microgravity application

NASA Technical Reports Server (NTRS)

Trolinger, James D.

1993-01-01

Holographic interferometry is a primary candidate for the measurement of temperature and concentration in various crystal growth experiments destined for space. The method measures refractive index changes in the experiment test cell. A refractive index change can be caused by concentration changes, temperature changes, or a combination of temperature and concentration changes. If the refractive index changes are caused by temperature and concentration changes occurring simultaneously in the experiment test cell, the contributions by the two effects cannot be separated by conventional measurement methods. By using two wavelengths, two independent interferograms can be produced from the reconstruction of the hologram. The two interferograms will be different due to dispersion properties of fluid materials. These differences provide the additional information that allows the separation of simultaneously occurring temperature and concentration gradients. There is no other technique available that can provide this type of information. The primary objectives of this effort are to experimentally verify the mathematical theory of two color holographic interferometry and to determine the practical value of this technique for space application. To achieve these objectives, the accuracy and sensitivity of the technique must be determined for geometry's and materials that are relevant to the Materials Processing in the Space program of NASA. This will be achieved through the use of a specially designed two-color holographic interferometry breadboard optical system. In addition to experiments to achieve the primary goals, the breadboard will also provide inputs to the design of an optimum space flight system.

Health care utilization of refugee children after resettlement.

PubMed

Watts, Delma-Jean; Friedman, Jennifer F; Vivier, Patrick M; Tompkins, Christine E A; Alario, Anthony J

2012-08-01

Refugee children can have significant health problems. Our objective was to describe health status and health care utilization of refugee children after resettlement. A retrospective chart review of refugee children was performed. Initial laboratory data was extracted. Primary care visits, emergency room visits, and subspecialty referrals in the first 15 months from arrival were recorded. The sample included 198 refugees, many with positive initial screening tests. After arrival, 21% had an emergency department visit, 40% had a primary care sick visit, and 71% had a primary care follow-up. Mean number of visits ranged from 0.3 for emergency department to 1.9 for follow-up. Fifty-seven percent were referred to at least one subspecialist. Refugee children had substantial disease burden at arrival. Most had primary care follow-up visits and subspecialty referral after resettlement. These visits were largely for problems identified on initial screening and for general pediatric illnesses.

Screening for colorectal cancer with FOBT, virtual colonoscopy and optical colonoscopy: study protocol for a randomized controlled trial in the Florence district (SAVE study)

PubMed Central

2013-01-01

Background Colorectal cancer (CRC) is the most frequent cancer in Europe. Randomized clinical trials demonstrated that screening with fecal occult blood test (FOBT) reduces mortality from CRC. Accordingly, the European Community currently recommends population-based screening with FOBT. Other screening tests, such as computed tomography colonography (CTC) and optical colonoscopy (OC), are highly accurate for examining the entire colon for adenomas and CRC. Acceptability represents a critical determinant of the impact of a screening program. We designed a randomized controlled trial to compare participation rate and diagnostic yield of FOBT, CTC with computer-aided diagnosis, and OC as primary tests for population-based screening. Methods/Design A total of 14,000 subjects aged 55 to 64 years, living in the Florence district and never screened for CRC, will be randomized in three arms: group 1 (5,000 persons) invited to undergo CTC (divided into: subgroup 1A with reduced cathartic preparation and subgroup 1B with standard bowel preparation); group 2 (8,000 persons) invited to undergo a biannual FOBT for three rounds; and group 3 (1,000 persons) invited to undergo OC. Subjects of each group will be invited by mail to undergo the selected test. All subjects with a positive FOBT or CTC test (that is, mass or at least one polyp ≥6 mm) will be invited to undergo a second-level OC. Primary objectives of the study are to compare the participation rate to FOBT, CTC and OC; to compare the detection rate for cancer or advanced adenomas of CTC versus three rounds of biannual FOBT; to evaluate referral rate for OC induced by primary CTC versus three rounds of FOBT; and to estimate costs of the three screening strategies. A secondary objective of the study is to create a biological bank of blood and stool specimens from subjects undergoing CTC and OC. Discussion This study will provide information about participation/acceptability, diagnostic yield and costs of screening with CTC in comparison with the recommended test (FOBT) and OC. Trial registration ClinicalTrials.gov Identifier: NCT01651624. PMID:23497601

Characterization of Orbital Debris Photometric Properties Derived from Laboratory-Based Measurements

NASA Technical Reports Server (NTRS)

Cowardin, Heather; Seitzer, Pat; Abercromby, Kira; Barker, Ed; Schildknecht, Thomas

2010-01-01

Capitalizing on optical data products and applying them to generate a more complete understanding of orbital space objects, is a key objective of NASA's Optical Measurement Program, and a primary objective for the creation of the Optical Measurements Center(OMC). The OMC attempts to emulate space-based illumination conditions using equipment and techniques that parallel telescopic observations and source-target-sensor orientations. The data acquired in the OMC are a function of known shape, size, and material. These three physical parameters are key to understanding the orbital debris environment in more depth. For optical observations, one must rely on spectroscopic or photometric measurements to ascertain an object's material type. Determination of an object s shape using remote observations is more complicated due to the various light scattering properties each object present and is a subject that requires more study. It is much easier to look at the periodicity of the light curve and analyze its structure for rotation. In order to best simulate the orbital debris population, three main sources were used as test fragments for optical measurements: flight-ready materials, destructive hypervelocity testing (simulating on-orbit collisions) and destructive pressure testing (simulating on-orbit explosions). Laboratory optical characteristics of fragments were measured, including light curve shape, phase angle dependence, and photometric and spectroscopic color indices. These characteristics were then compared with similar optical measurements acquired from telescopic observations in order to correlate remote and laboratory properties with the intent of ascertaining the intrinsic properties of the observed orbital debris

Cutting Efficiency of Instruments with Different Movements: a Comparative Study

PubMed Central

Plotino, Gianluca; Al-Sudani, Dina; Rubini, Alessio Giansiracusa; Sannino, Gianpaolo; Piasecki, Lucila; Putortì, Ermanno; Testarelli, Luca; Gambarini, Gianluca

2015-01-01

ABSTRACT Objectives The aim of the present study was to evaluate the cutting efficiency of two new reciprocating instruments, Twisted File Adaptive and WaveOne Primary. Material and Methods 10 new Twisted File Adaptive (TF Adaptive) (SybronEndo, Glendora, CA, USA) and 10 new WaveOne Primary files (Dentsply Maillefer, Ballaigues, Switzerland) were activated using a torque-controlled motor, respectively TFA motor (SybronEndo, Glendora, CA, USA) and Silver motor (VDW, Munich, Germany). The device used for the cutting test consisted on a mainframe to which a mobile plastic support for the hand-piece is connected and a stainless-steel block containing a Plexiglas block against which the cutting efficiency of the instruments was tested. The length of the block cut in 1 minute was measured in a computerized program with a precision of 0.1 mm. Mean and standard deviations of each group were calculated and data were statistically analyzed with one-way ANOVA and Bonferroni t test (P < 0.05). Results TF Adaptive displayed significantly greater maximum penetration depth than WaveOne Primary (P < 0.05). In fact, TF Adaptive instruments (Group 1) cut the Plexiglas block to a mean depth of 8.7 (SD 0.5) mm, while WaveOne Primary instruments cut the Plexiglas block to a mean depth of 6.4 (SD 0.3) mm. Conclusions Twisted File Adaptive instruments demonstrated statistically higher cutting efficiency than WaveOne instruments. PMID:25937877

Sub-Scale Testing and Development of the J-2X Fuel Turbopump Inducer

NASA Technical Reports Server (NTRS)

Sargent, Scott R.; Becht, David G.

2011-01-01

In the early stages of the J-2X upper stage engine program, various inducer configurations proposed for use in the fuel turbopump (FTP) were tested in water. The primary objectives of this test effort were twofold. First, to obtain a more comprehensive data set than that which existed in the Pratt & Whitney Rocketdyne (PWR) historical archives from the original J-2S program, and second, to supplement that data set with information regarding the cavitation induced vibrations for both the historical J-2S configuration as well as those tested for the J-2X program. The J-2X FTP inducer, which actually consists of an inducer stage mechanically attached to a kicker stage, underwent 4 primary iterations utilizing sub-scaled test articles manufactured and tested in PWR's Engineering Development Laboratory (EDL). The kicker remained unchanged throughout the test series. The four inducer configurations tested retained many of the basic design features of the J-2S inducer, but also included variations on leading edge blade thickness and blade angle distribution, primarily aimed at improving suction performance at higher flow coefficients. From these data sets, the effects of the tested design variables on hydrodynamic performance and cavitation instabilities were discerned. A limited comparison of impact to the inducer efficiency was determined as well.

Duration of antibody response following vaccination against feline immunodeficiency virus.

PubMed

Westman, Mark E; Malik, Richard; Hall, Evelyn; Harris, Matthew; Hosie, Margaret J; Norris, Jacqueline M

2017-10-01

Objectives Recently, two point-of-care (PoC) feline immunodeficiency virus (FIV) antibody test kits (Witness and Anigen Rapid) were reported as being able to differentiate FIV-vaccinated from FIV-infected cats at a single time point, irrespective of the gap between testing and last vaccination (0-7 years). The aim of the current study was to investigate systematically anti-FIV antibody production over time in response to the recommended primary FIV vaccination series. Methods First, residual plasma from the original study was tested using a laboratory-based ELISA to determine whether negative results with PoC testing were due to reduced as opposed to absent antibodies to gp40. Second, a prospective study was performed using immunologically naive client-owned kittens and cats given a primary FIV vaccination series using a commercially available inactivated whole cell/inactivated whole virus vaccine (Fel-O-Vax FIV, three subcutaneous injections at 4 week intervals) and tested systematically (up to 11 times) over 6 months, using four commercially available PoC FIV antibody kits (SNAP FIV/FeLV Combo [detects antibodies to p15/p24], Witness FeLV/FIV [gp40], Anigen Rapid FIV/FeLV [p24/gp40] and VetScan FeLV/FIV Rapid [p24]). Results The laboratory-based ELISA showed cats from the original study vaccinated within the previous 0-15 months had detectable levels of antibodies to gp40, despite testing negative with two kits that use gp40 as a capture antigen (Witness and Anigen Rapid kits). The prospective study showed that antibody testing with SNAP Combo and VetScan Rapid was positive in all cats 2 weeks after the second primary FIV vaccination, and remained positive for the duration of the study (12/12 and 10/12 cats positive, respectively). Antibody testing with Witness and Anigen Rapid was also positive in a high proportion of cats 2 weeks after the second primary FIV vaccination (8/12 and 7/12, respectively), but antibody levels declined below the level of detection in most cats (10/12) by 1 month after the third (final) primary FIV vaccination. All cats tested negative using Witness and Anigen Rapid 6 months after the third primary FIV vaccination. Conclusions and relevance This study has shown that a primary course of FIV vaccination does not interfere with FIV antibody testing in cats using Witness and Anigen Rapid, provided primary vaccination has not occurred within the previous 6 months. Consequently, Witness and Anigen Rapid antibody test kits can be used reliably to determine FIV infection status at the time of annual booster FIV vaccination to help detect 'vaccine breakthroughs' and in cats that have not received a primary course of FIV vaccination within the preceding 6 months. The duration of antibody response following annual booster FIV vaccination and the resulting effect on antibody testing using PoC kits needs to be determined by further research. The mechanism(s) for the variation in FIV antibody test kit performance remains unclear.

Full-scale hingeless rotor performance and loads

NASA Technical Reports Server (NTRS)

Peterson, Randall L.

1995-01-01

A full-scale BO-105 hingeless rotor system was tested in the NASA Ames 40- by 80-Foot Wind Tunnel on the rotor test apparatus. Rotor performance, rotor loads, and aeroelastic stability as functions of both collective and cyclic pitch, tunnel velocity, and shaft angle were investigated. This test was performed in support of the Rotor Data Correlation Task under the U.S. Army/German Memorandum of Understanding on Cooperative Research in the Field of Helicopter Aeromechanics. The primary objective of this test program was to create a data base for full-scale hingeless rotor performance and structural blade loads. A secondary objective was to investigate the ability to match flight test conditions in the wind tunnel. This data base can be used for the experimental and analytical studies of hingeless rotor systems over large variations in rotor thrust and tunnel velocity. Rotor performance and structural loads for tunnel velocities from hover to 170 knots and thrust coefficients (C(sub T)/sigma) from 0.0 to 0.12 are presented in this report. Thrust sweeps at tunnel velocities of 10, 20, and 30 knots are also included in this data set.

Validation of a moral distress instrument in nurses of primary health care 1

PubMed Central

Barth, Priscila Orlandi; Ramos, Flávia Regina Souza; Barlem, Edison Luiz Devos; Dalmolin, Graziele de Lima; Schneider, Dulcinéia Ghizoni

2018-01-01

ABSTRACT Objective: to validate an instrument to identify situations that trigger moral distress in relation to intensity and frequency in primary health care nurses. Method: this is a methodological study carried out with 391 nurses of primary health care, applied to the Brazilian Scale of Moral Distress in Nurses with 57 questions. Validation for primary health care was performed through expert committee evaluation, pre-test, factorial analysis, and Cronbach’s alpha. Results: there were 46 questions validated divided into six constructs: Health Policies, Working Conditions, Nurse Autonomy, Professional ethics, Disrespect to patient autonomy and Work Overload. The instrument had satisfactory internal consistency, with Cronbach’s alpha 0.98 for the instrument, and between 0.96 and 0.88 for the constructs. Conclusion: the instrument is valid and reliable to be used in the identification of the factors that trigger moral distress in primary care nurses, providing subsidies for new research in this field of professional practice. PMID:29791671

Pathogenic variants in TUBB4A are not found in primary dystonia

PubMed Central

Vemula, Satya R.; Xiao, Jianfeng; Bastian, Robert W.; Momčilović, Dragana; Blitzer, Andrew

2014-01-01

Objective: To determine the contribution of TUBB4A, recently associated with DYT4 dystonia in a pedigree with “whispering dysphonia” from Norfolk, United Kingdom, to the etiopathogenesis of primary dystonia. Methods: High-resolution melting and Sanger sequencing were used to inspect the entire coding region of TUBB4A in 575 subjects with primary laryngeal, segmental, or generalized dystonia. Results: No pathogenic variants, including the exon 1 variant (c.4C>G) identified in the DYT4 whispering dysphonia kindred, were found in this study. Conclusion: The c.4C>G DYT4 mutation appears to be private, and clinical testing for TUBB4A mutations is not justified in spasmodic dysphonia or other forms of primary dystonia. Moreover, given its allelic association with leukoencephalopathy hypomyelination with atrophy of basal ganglia and cerebellum and protean clinical manifestations (chorea, ataxia, dysarthria, intellectual disability, dysmorphic facial features, and psychiatric disorders), DYT4 should not be categorized as a primary dystonia. PMID:24598712

Radiotherapy-induced xerostomia, pre-clinical promise of LMS-611.

PubMed

Paterson, Claire; Caldwell, B; Porteous, S; McLean, A; Messow, C M; Thomson, M

2016-02-01

Radiotherapy-induced xerostomia (RIX) is the most common permanent side effect of radiotherapy (RT) to the head and neck (H&N). There is no effective topical treatment. LMS-611 is a mimetic of a natural lamellar body which prevents thick secretions like saliva from congesting organs. The primary objective of this study was to assess saliva properties before and during RT to the H&N. The secondary objectives were to re-assess saliva properties with the addition of LMS-611, measure inter-patient variability, correlate patient-reported symptoms with laboratory measurements and design subsequent first-in-human clinical trial of LMS-611. Patients with H&N cancer receiving RT as primary treatment were recruited. Patients completed the Groningen RIX (GRIX) questionnaire and provided saliva samples at baseline and weeks 2, 4 and 6 of RT. Saliva adhesiveness and viscosity were tested by measuring time taken to travel 5 cm down an inclined plane. Thirty patients were enrolled. The inclined plane test (IPT) results (s) were as follows: baseline 31.3, week 2 49.7, week 4 51.1 and week 6 55.7. Wide inter-patient variability was seen at baseline. GRIX scores increased as RT progressed. Spearman rank correlation coefficient of inclined plane tests with GRIX scores was -0.06 at baseline, 0.25 at week 2, 0.12 at week 4 and 0.08 at week 6. LMS-611 concentrations of 10 and 20 mg/ml significantly reduced IPT times on saliva samples. Saliva becomes more visco-adhesive and RIX worsens as RT progresses. There is little correlation between objective and subjective measures of RIX. The addition of LMS-611 to thick, sticky saliva restores its fluidity ex vivo. This warrants in vivo analysis of the effect of LMS-611 upon RIX.

Comparison of the microhardness of primary and permanent teeth after immersion in two types of carbonated beverages

PubMed Central

Haghgou, Hamid R.; Haghgoo, Roza; Asdollah, Fatemah Molla

2016-01-01

Objectives: The consumption of carbonated beverages is one of the etiological factors that cause dental erosion. The purpose of this research was to compare changes in the microhardness of permanent and primary teeth after immersion in two types of carbonated beverages. Materials and Methods: This investigation was done on 30 healthy permanent molars and 30 healthy primary canines. Each group of primary and permanent teeth was subdivided into three groups of 10 teeth. The teeth was immersed in 40 ml of each of the three beverages for 5 min. One subgroup was immersed in water (as a control). The next was immersed in Lemon Delster and the last subgroup was immersed in Coca-Cola. The microhardness of enamel was measured using the Vickers method before and after immersion. Finally, the data was analyzed by paired t-test, one-way analysis of variance, and t-test. Results: Microhardness reduction in the primary teeth was significant in both the Lemon Delster and Coca-Cola groups (P < 0.05). This reduction was also statistically significant in the permanent teeth (P < 0.05). A comparison of the enamel changes in the primary teeth with permanent teeth after immersion in both beverages showed a greater microhardness reduction in the primary teeth in both the experimental groups. Conclusions: Coca-Cola and Lemon Delster caused a significant reduction of microhardness in tooth enamel. This reduction was greater in primary teeth than in permanent teeth, and was also greater after immersion in Coca-Cola than after immersion in Lemon Delster. PMID:27583223

Results of an aerodynamic force and moment investigation of an 0.015-scale configuration 3 space shuttle orbiter in the NASA/ARC 3.5-foot hypersonic wind tunnel (OA58)

NASA Technical Reports Server (NTRS)

Dziubala, T. J.; Cleary, J. W.

1974-01-01

The primary objective of the test was to obtain stability and control data for the basic configuration and an alternate configuration for the Space Shuttle Orbiter. Pitch runs were made with 0 deg of sideslip at Mach numbers of 5.3, 7.3 and 10.3. Six-component force data and fuselage base pressures were recorded for each run. Shadowgraph pictures were taken at selected points. Model 420 was used for the tests.

TAMOAS: In Situ Gasometry in the Atmosphere with Solid Electrolyte Sensors on BEXUS-19

NASA Astrophysics Data System (ADS)

Bronowski, A.; Clemens, R.; Jaster, T.; Kosel, F.; Matyash, I.; Westphal, A.

2015-09-01

A student experiment developed for testing gas sensors in the stratosphere is described. The setup consists of a measurement electronic running miniaturized in situ amperiometric gas sensors based on different solid state electrolytes dedicated for oxygen, ozone and atomic oxygen. The experiment took place at Esrange Space Center in October 2014. The setup was attached to the high-altitude balloon BEXUS-19 and reached an altitude of 27 km at night. The primary objective was to test the prototype sensors and to gain data during flight.

Testing of Sapphire Optical Fiber and Sensors in Intense Radiation Fields When Subjected to Very High Temperatures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blue, Thomas; Windl, Wolfgang

The primary objective of this project was to determine the optical attenuation and signal degradation of sapphire optical fibers & sensors (temperature & strain), in-situ, operating at temperatures up to 1500°C during reactor irradiation through experiments and modeling. The results will determine the feasibility of extending sapphire optical fiber-based instrumentation to extremely high temperature radiation environments. This research will pave the way for future testing of sapphire optical fibers and fiber-based sensors under conditions expected in advanced high temperature reactors.

Test model designs for advanced refractory ceramic materials

NASA Technical Reports Server (NTRS)

Tran, Huy Kim

1993-01-01

The next generation of space vehicles will be subjected to severe aerothermal loads and will require an improved thermal protection system (TPS) and other advanced vehicle components. In order to ensure the satisfactory performance system (TPS) and other advanced vehicle materials and components, testing is to be performed in environments similar to space flight. The design and fabrication of the test models should be fairly simple but still accomplish test objectives. In the Advanced Refractory Ceramic Materials test series, the models and model holders will need to withstand the required heat fluxes of 340 to 817 W/sq cm or surface temperatures in the range of 2700 K to 3000 K. The model holders should provide one dimensional (1-D) heat transfer to the samples and the appropriate flow field without compromising the primary test objectives. The optical properties such as the effective emissivity, catalytic efficiency coefficients, thermal properties, and mass loss measurements are also taken into consideration in the design process. Therefore, it is the intent of this paper to demonstrate the design schemes for different models and model holders that would accommodate these test requirements and ensure the safe operation in a typical arc jet facility.

Outcomes Definitions and Statistical Tests in Oncology Studies: A Systematic Review of the Reporting Consistency.

PubMed

Rivoirard, Romain; Duplay, Vianney; Oriol, Mathieu; Tinquaut, Fabien; Chauvin, Franck; Magne, Nicolas; Bourmaud, Aurelie

2016-01-01

Quality of reporting for Randomized Clinical Trials (RCTs) in oncology was analyzed in several systematic reviews, but, in this setting, there is paucity of data for the outcomes definitions and consistency of reporting for statistical tests in RCTs and Observational Studies (OBS). The objective of this review was to describe those two reporting aspects, for OBS and RCTs in oncology. From a list of 19 medical journals, three were retained for analysis, after a random selection: British Medical Journal (BMJ), Annals of Oncology (AoO) and British Journal of Cancer (BJC). All original articles published between March 2009 and March 2014 were screened. Only studies whose main outcome was accompanied by a corresponding statistical test were included in the analysis. Studies based on censored data were excluded. Primary outcome was to assess quality of reporting for description of primary outcome measure in RCTs and of variables of interest in OBS. A logistic regression was performed to identify covariates of studies potentially associated with concordance of tests between Methods and Results parts. 826 studies were included in the review, and 698 were OBS. Variables were described in Methods section for all OBS studies and primary endpoint was clearly detailed in Methods section for 109 RCTs (85.2%). 295 OBS (42.2%) and 43 RCTs (33.6%) had perfect agreement for reported statistical test between Methods and Results parts. In multivariable analysis, variable "number of included patients in study" was associated with test consistency: aOR (adjusted Odds Ratio) for third group compared to first group was equal to: aOR Grp3 = 0.52 [0.31-0.89] (P value = 0.009). Variables in OBS and primary endpoint in RCTs are reported and described with a high frequency. However, statistical tests consistency between methods and Results sections of OBS is not always noted. Therefore, we encourage authors and peer reviewers to verify consistency of statistical tests in oncology studies.

Outcomes Definitions and Statistical Tests in Oncology Studies: A Systematic Review of the Reporting Consistency

PubMed Central

Rivoirard, Romain; Duplay, Vianney; Oriol, Mathieu; Tinquaut, Fabien; Chauvin, Franck; Magne, Nicolas; Bourmaud, Aurelie

2016-01-01

Background Quality of reporting for Randomized Clinical Trials (RCTs) in oncology was analyzed in several systematic reviews, but, in this setting, there is paucity of data for the outcomes definitions and consistency of reporting for statistical tests in RCTs and Observational Studies (OBS). The objective of this review was to describe those two reporting aspects, for OBS and RCTs in oncology. Methods From a list of 19 medical journals, three were retained for analysis, after a random selection: British Medical Journal (BMJ), Annals of Oncology (AoO) and British Journal of Cancer (BJC). All original articles published between March 2009 and March 2014 were screened. Only studies whose main outcome was accompanied by a corresponding statistical test were included in the analysis. Studies based on censored data were excluded. Primary outcome was to assess quality of reporting for description of primary outcome measure in RCTs and of variables of interest in OBS. A logistic regression was performed to identify covariates of studies potentially associated with concordance of tests between Methods and Results parts. Results 826 studies were included in the review, and 698 were OBS. Variables were described in Methods section for all OBS studies and primary endpoint was clearly detailed in Methods section for 109 RCTs (85.2%). 295 OBS (42.2%) and 43 RCTs (33.6%) had perfect agreement for reported statistical test between Methods and Results parts. In multivariable analysis, variable "number of included patients in study" was associated with test consistency: aOR (adjusted Odds Ratio) for third group compared to first group was equal to: aOR Grp3 = 0.52 [0.31–0.89] (P value = 0.009). Conclusion Variables in OBS and primary endpoint in RCTs are reported and described with a high frequency. However, statistical tests consistency between methods and Results sections of OBS is not always noted. Therefore, we encourage authors and peer reviewers to verify consistency of statistical tests in oncology studies. PMID:27716793

Evaluating topic model interpretability from a primary care physician perspective.

PubMed

Arnold, Corey W; Oh, Andrea; Chen, Shawn; Speier, William

2016-02-01

Probabilistic topic models provide an unsupervised method for analyzing unstructured text. These models discover semantically coherent combinations of words (topics) that could be integrated in a clinical automatic summarization system for primary care physicians performing chart review. However, the human interpretability of topics discovered from clinical reports is unknown. Our objective is to assess the coherence of topics and their ability to represent the contents of clinical reports from a primary care physician's point of view. Three latent Dirichlet allocation models (50 topics, 100 topics, and 150 topics) were fit to a large collection of clinical reports. Topics were manually evaluated by primary care physicians and graduate students. Wilcoxon Signed-Rank Tests for Paired Samples were used to evaluate differences between different topic models, while differences in performance between students and primary care physicians (PCPs) were tested using Mann-Whitney U tests for each of the tasks. While the 150-topic model produced the best log likelihood, participants were most accurate at identifying words that did not belong in topics learned by the 100-topic model, suggesting that 100 topics provides better relative granularity of discovered semantic themes for the data set used in this study. Models were comparable in their ability to represent the contents of documents. Primary care physicians significantly outperformed students in both tasks. This work establishes a baseline of interpretability for topic models trained with clinical reports, and provides insights on the appropriateness of using topic models for informatics applications. Our results indicate that PCPs find discovered topics more coherent and representative of clinical reports relative to students, warranting further research into their use for automatic summarization. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Assessing a Self-Report Health Measure for Non-English-Speaking Elders: Issues in Using the SF-36 Health Survey

ERIC Educational Resources Information Center

Jordan-Marsh, Maryalice; Cody, Michael; Silverstein, Merril; Chin, Soo-Young; Garcia, Ruth

2008-01-01

Objective: Approved versions of the SF-36 Version 1.0 are used for limited-English-speaking individuals whose primary languages are Korean, Chinese, and Spanish to test the respective translations for use among immigrants to the United States. Method: Surveys are completed by an older adult and a nominated adult family caregiver (N = 132).…

NASA-DoD Lead-Free Electronics Project

NASA Technical Reports Server (NTRS)

Kessel, Kurt R.

2009-01-01

The primary technical objective of this project is to undertake comprehensive testing to generate information on failure modes/criteria to better understand the reliability of: (1) Packages (e.g., Thin Small Outline Package [TSOP], Ball Grid Array [BGA], Plastic Dual In-line Package [PDIP]) assembled and reworked with lead-free alloys, (2) Packages (e.g., TSOP, BGA, PDIP) assembled and reworked with mixed (lead/lead-free) alloys.

Flight Test Assessments of Pilot Workload, System Usability, and Situation Awareness of TASAR

NASA Technical Reports Server (NTRS)

Burke, Kelly A.; Haynes, Mark A.

2016-01-01

Traffic Aware Strategic Aircrew Requests (TASAR) is an onboard automation concept intended to identify trajectory optimizations, in terms of fuel and time saving objectives, clear of known traffic, weather, and airspace restrictions prior to the aircrew initiating a route-change request to Air Traffic Control (ATC). The software implementation of the TASAR concept is the Traffic Aware Planner (TAP). TASAR analysis and development is being executed by the NASA Langley Research Center's Crew Systems and Aviation Operations Branch (CSAOB) under the sponsorship of the Airspace Technology Demonstration (ATD) Project of the NASA Airspace Operations and Safety Program (AOSP). The TASAR Flight Trial-2 (FT-2) was conducted in June, 2015 out of the Newport News/Williamsburg International Airport. This flight trial was conducted using a Piaggio Avanti flight test aircraft and consisted of 12 Evaluation Flights with airline commercial pilots participating as the Evaluation Pilots, three destination airports in Atlanta and Jacksonville Air Route Traffic Control Centers, and one pair of flight plans associated with each destination airport. The primary goal of FT-2 was to reduce risk for upcoming operational trials with NASA partner airlines, Alaska Airlines and Virgin America. To accomplish this primary goal, six independent objectives were conducted during FT-2, however, this paper will report only the findings of Objective 5; the assessment of system usability, pilot perceived workload, and the degree of pilot acceptability of the TAP Human Machine Interface (HMI) during flight operations, via the administration of several subjective measures.

High Current ESD Test of Advanced Triple Junction Solar Array Coupon

NASA Technical Reports Server (NTRS)

Wright, Kenneth H., Jr.; Schneider, Todd A.; Vaughn, Jason A.; Hoang, Bao; Wong, Frankie

2014-01-01

Testing was conducted on an Advanced Triple Junction (ATJ) coupon that was part of a risk reduction effort in the development of a high-powered solar array design by Space Systems Loral, LLC (SSL). The ATJ coupon was a small, 4-cell, two-string configuration of flight-type design that has served as the basic test coupon design used in previous SSL environmental aging campaigns. The objective of the present test was to evaluate the performance of the coupon after being subjected to induced electrostatic discharge (ESD) testing at two string voltages (100 V, 150 V) and four string currents (1.65 A, 2.0 A, 2.475 A, and 3.3 A). An ESD test circuit, unique to SSL solar array design, was built that simulates the effect of missing cells and strings in a full solar panel with special primary arc flashover circuitry. A total of 73 primary arcs were obtained that included 7 temporary sustained arcs (TSA) events. The durations of the TSAs ranged from 50 micro-seconds to 2.75 milli-seconds. All TSAs occurred at a string voltage of 150 V. Post-ESD functional testing showed that no degradation occurred due to the TSA events. These test results point to a robust design for application to a high-current, high-power mission.

Primary Screening for Cervical Cancer Based on High-Risk Human Papillomavirus (HPV) Detection and HPV 16 and HPV 18 Genotyping, in Comparison to Cytology

PubMed Central

Constantinidis, Theocharis; Constantinidis, Theodoros C.

2015-01-01

Objectives The objective of the present study is to assess the performance of a high-risk human papillomavirus (HR-HPV) DNA test with individual HPV-16/HPV-18 genotyping as a method for primary cervical cancer screening compared with liquid-based cytology (LBC) in a population of Greek women taking part in routine cervical cancer screening. Methods The study, conducted by the “HEllenic Real life Multicentric cErvical Screening” (HERMES) study group, involved the recruitment of 4,009 women, aged 25–55, who took part in routine cervical screening at nine Gynecology Departments in Greece. At first visit cervical specimens were collected for LBC and HPV testing using the Roche Cobas 4800 system. Women found positive for either cytology or HPV were referred for colposcopy, whereas women negative for both tests will be retested after three years. The study is ongoing and the results of the first screening round are reported herein. Results Valid results for cytology and HPV testing were obtained for 3,993 women. The overall prevalence of HR-HPV was 12.7%, of HPV-16 2.7% and of HPV-18 1.4%. Of those referred for colposcopy, cervical intraepithelial neoplasia grade 2 or worse (CIN2+) was detected in 41 women (1.07%). At the threshold of CIN2+, cytology [atypical squamous cells of undetermined significance (ASC-US) or worse] and HPV testing showed a sensitivity of 53.7% and 100% respectively, without change between age groups. Cytology and HPV testing showed specificity of 96.8% and 90.3% respectively, which was increased in older women (≥30) in comparison to younger ones (25–29). Genotyping for HPV16/18 had similar accuracy to cytology for the detection of CIN2+ (sensitivity: 58.5%; specificity 97.5%) as well as for triage to colposcopy (sensitivity: 58.5% vs 53.7% for cytology). Conclusion HPV testing has much better sensitivity than cytology to identify high-grade cervical lesions with slightly lower specificity. HPV testing with individual HPV-16/HPV-18 genotyping could represent a more accurate methodology for primary cervical cancer screening in comparison to liquid-based cytology, especially in older women. PMID:25793281

Standardization Tests of NACA No. 1 Wind Tunnel

NASA Technical Reports Server (NTRS)

Reid, Elliott G

1925-01-01

The tests described in this report were made in the 5-foot atmospheric wind tunnel of the National Advisory Committee for Aeronautics, at Langley Field. The primary objective of collecting data on the characteristics of this tunnel for comparison with those of others throughout the world, in order that, in the future, the results of tests made in all the principle laboratories may be interpreted, compared, and coordinated on a basis of scientifically established relationships, a process hitherto impossible due to the lack of comparable data. The work includes tests of a disk, spheres, cylinders, and airfoils, explorations of the test section for static pressure and velocity distribution, and determination of the variations of air flow direction throughout the operating range of the tunnel. (author)

Wing Torsional Stiffness Tests of the Active Aeroelastic Wing F/A-18 Airplane

NASA Technical Reports Server (NTRS)

Lokos, William A.; Olney, Candida D.; Crawford, Natalie D.; Stauf, Rick; Reichenbach, Eric Y.

2002-01-01

The left wing of the Active Aeroelastic Wing (AAW) F/A-18 airplane has been ground-load-tested to quantify its torsional stiffness. The test has been performed at the NASA Dryden Flight Research Center in November 1996, and again in April 2001 after a wing skin modification was performed. The primary objectives of these tests were to characterize the wing behavior before the first flight, and provide a before-and-after measurement of the torsional stiffness. Two streamwise load couples have been applied. The wing skin modification is shown to have more torsional flexibility than the original configuration has. Additionally, structural hysteresis is shown to be reduced by the skin modification. Data comparisons show good repeatability between the tests.

Standard Specimen Reference Set: Breast Cancer and Imaging — EDRN Public Portal

Cancer.gov

The primary objective of this study is to assemble a well-characterized set of blood specimens and images to test biomarkers that, in conjunction with mammography, can detect and discriminate breast cancer. These samples will be divided to provide “sets” of specimens that can be tested in a number of different laboratories. Since tests will be performed on the same sets of samples, the data will be directly comparable and decisions regarding which biomarker or set of biomarkers have value in breast cancer detection can be made. These sets will reside at a National Cancer Institute facility at Frederick, MD.

Telemedicine spirometry training and quality assurance program in primary care centers of a public health system.

PubMed

Marina Malanda, Nuria; López de Santa María, Elena; Gutiérrez, Asunción; Bayón, Juan Carlos; Garcia, Larraitz; Gáldiz, Juan B

2014-04-01

Forced spirometry is essential for diagnosing respiratory diseases and is widely used across levels of care. However, several studies have shown that spirometry quality in primary care is not ideal, with risks of misdiagnosis. Our objective was to assess the feasibility and performance of a telemedicine-based training and quality assurance program for forced spirometry in primary care. The two phases included (1) a 9-month pilot study involving 15 centers, in which spirometry tests were assessed by the Basque Office for Health Technology Assessment, and (2) the introduction of the program to all centers in the Public Basque Health Service. Technicians first received 4 h of training, and, subsequently, they sent all tests to the reference laboratory using the program. Quality assessment was performed in accordance with clinical guidelines (A and B, good; C-F, poor). In the first phase, 1,894 spirometry tests were assessed, showing an improvement in quality: acceptable quality tests increased from 57% at the beginning to 78% after 6 months and 83% after 9 months (p<0.001). In the second phase, 7,200 spirometry tests were assessed after the inclusion of 36 additional centers, maintaining the positive trend (61%, 87%, and 84% at the same time points; p<0.001). (1) The quality of spirometry tests improved in all centers. (2) The program provides a tool for transferring data that allows monitoring of its quality and training of technicians who perform the tests. (3) This approach is useful for improving spirometry quality in the routine practice of a public health system.

Primary care physicians' perceived barriers and facilitators to conservative care for older adults with chronic kidney disease: design of a mixed methods study.

PubMed

Tam-Tham, Helen; Hemmelgarn, Brenda; Campbell, David; Thomas, Chandra; Quinn, Robert; Fruetel, Karen; King-Shier, Kathryn

2016-01-01

Guideline committees have identified the need for research to inform the provision of conservative care for older adults with stage 5 chronic kidney disease (CKD) who have a high burden of comorbidity or functional impairment. We will use both qualitative and quantitative methodologies to provide a comprehensive understanding of barriers and facilitators to care for these patients in primary care. Our objectives are to (1) interview primary care physicians to determine their perspectives of conservative care for older adults with stage 5 CKD and (2) survey primary care physicians to determine the prevalence of key barriers and facilitators to provision of conservative care for older adults with stage 5 CKD. A sequential exploratory mixed methods design was adopted for this study. The first phase of the study will involve fundamental qualitative description and the second phase will be a cross-sectional population-based survey. The research is conducted in Alberta, Canada. The participants are primary care physicians with experience in providing care for older adults with stage 5 CKD not planning on initiating dialysis. The first objective will be achieved by undertaking interviews with primary care physicians from southern Alberta. Participants will be selected purposively to include physicians with a range of characteristics (e.g., age, gender, and location of clinical practice). Interviews will be recorded, transcribed verbatim, and analyzed using conventional content analysis to generate themes. The second objective will be achieved by undertaking a population-based survey of primary care physicians in Alberta. The questionnaire will be developed based on the findings from the qualitative interviews and pilot tested for face and content validity. Physicians will be provided multiple options to complete the questionnaire including mail, fax, and online methods. Descriptive statistics and associations between demographic factors and barriers and facilitators to care will be analyzed using regression models. A potential limitation of this mixed methods study is its cross-sectional nature. This work will inform development of clinical resources and tools for care of older adults with stage 5 CKD, to address barriers and enable facilitators to community-based conservative care.

Efficacy of the alcohol use disorders identification test as a screening tool for hazardous alcohol intake and related disorders in primary care: a validity study.

PubMed Central

Piccinelli, M.; Tessari, E.; Bortolomasi, M.; Piasere, O.; Semenzin, M.; Garzotto, N.; Tansella, M.

1997-01-01

OBJECTIVE: To determine the properties of the alcohol use disorders identification test in screening primary care attenders for alcohol problems. DESIGN: A validity study among consecutive primary care attenders aged 18-65 years. Every third subject completed the alcohol use disorders identification test (a 10 item self report questionnaire on alcohol intake and related problems) and was interviewed by an investigator with the composite international diagnostic interview alcohol use module (a standardised interview for the independent assessment of alcohol intake and related disorders). SETTING: 10 primary care clinics in Verona, north eastern Italy. PATIENTS: 500 subjects were approached and 482 (96.4%) completed evaluation. RESULTS: When the alcohol use disorders identification test was used to detect subjects with alcohol problems the area under the receiver operating characteristic curve was 0.95. The cut off score of 5 was associated with a sensitivity of 0.84, a specificity of 0.90, and a positive predictive value of 0.60. The screening ability of the total score derived from summing the responses to the five items minimising the probability of misclassification between subjects with and without alcohol problems provided an area under the receiver operating characteristic curve of 0.93. A score of 5 or more on the five items was associated with a sensitivity of 0.79, a specificity of 0.95, and a positive predictive value of 0.73. CONCLUSIONS: The alcohol use disorders identification test performs well in detecting subjects with formal alcohol disorders and those with hazardous alcohol intake. Using five of the 10 items on the questionnaire gives reasonable accuracy, and these are recommended as questions of choice to screen patients for alcohol problems. PMID:9040389

Cardiovascular Genetic Risk Testing for Targeting Statin Therapy in the Primary Prevention of Atherosclerotic Cardiovascular Disease: A Cost-Effectiveness Analysis.

PubMed

Jarmul, Jamie; Pletcher, Mark J; Hassmiller Lich, Kristen; Wheeler, Stephanie B; Weinberger, Morris; Avery, Christy L; Jonas, Daniel E; Earnshaw, Stephanie; Pignone, Michael

2018-04-01

It is unclear whether testing for novel risk factors, such as a cardiovascular genetic risk score (cGRS), improves clinical decision making or health outcomes when used for targeting statin initiation in the primary prevention of atherosclerotic cardiovascular disease (ASCVD). Our objective was to estimate the cost-effectiveness of cGRS testing to inform clinical decision making about statin initiation in individuals with low-to-intermediate (2.5%-7.5%) 10-year predicted risk of ASCVD. We evaluated the cost-effectiveness of testing for a 27-single-nucleotide polymorphism cGRS comparing 4 test/treat strategies: treat all, treat none, test/treat if cGRS is high, and test/treat if cGRS is intermediate or high. We tested a set of clinical scenarios of men and women, aged 45 to 65 years, with 10-year ASCVD risks between 2.5% and 7.5%. Our primary outcome measure was cost per quality-adjusted life-year gained. Under base case assumptions for statin disutility and cost, the preferred strategy is to treat all patients with ASCVD risk >2.5% without cGRS testing. For certain clinical scenarios, such as a 57-year-old man with a 10-year ASCVD risk of 7.5%, cGRS testing can be cost-effective under a limited set of assumptions; for example, when statins cost $15 per month and statin disutility is 0.013 (ie, willing to trade 3 months of life in perfect health to avoid 20 years of statin therapy), the preferred strategy (using a willingness-to-pay threshold of $50 000 per quality-adjusted life-year gained) is to test and treat if cGRS is intermediate or high. Overall, the results were not sensitive to assumptions about statin efficacy and harms. Testing for a 27-single-nucleotide polymorphism cGRS is generally not a cost-effective approach for targeting statin therapy in the primary prevention of ASCVD for low- to intermediate-risk patients. © 2018 American Heart Association, Inc.

Qualitative interviews with healthcare staff in four European countries to inform adaptation of an intervention to increase chlamydia testing

PubMed Central

McNulty, Cliodna; Ricketts, Ellie J; Fredlund, Hans; Uusküla, Anneli; Town, Katy; Rugman, Claire; Tisler-Sala, Anna; Mani, Alix; Dunais, Brigitte; Folkard, Kate; Allison, Rosalie; Touboul, Pia

2017-01-01

Objective To determine the needs of primary healthcare general practice (GP) staff, stakeholders and trainers to inform the adaptation of a locally successful complex intervention (Chlamydia Intervention Randomised Trial (CIRT)) aimed at increasing chlamydia testing within primary healthcare within South West England to three EU countries (Estonia, France and Sweden) and throughout England. Design Qualitative interviews. Setting European primary healthcare in England, France, Sweden and Estonia with a range of chlamydia screening provision in 2013. Participants 45 GP staff, 13 trainers and 18 stakeholders. Interviews The iterative interview schedule explored participants’ personal attitudes, subjective norms and perceived behavioural controls around provision of chlamydia testing, sexual health services and training in general practice. Researchers used a common thematic analysis. Results Findings were similar across all countries. Most participants agreed that chlamydia testing and sexual health services should be offered in general practice. There was no culture of GP staff routinely offering opportunistic chlamydia testing or sexual health advice, and due to other priorities, participants reported this would be challenging. All participants indicated that the CIRT workshop covering chlamydia testing and sexual health would be useful if practice based, included all practice staff and action planning, and was adequately resourced. Participants suggested minor adaptations to CIRT to suit their country’s health services. Conclusions A common complex intervention can be adapted for use across Europe, despite varied sexual health provision. The intervention (ChlamydiA Testing Training in Europe (CATTE)) should comprise: a staff workshop covering sexual health and chlamydia testing rates and procedures, action planning and patient materials and staff reminders via computer prompts, emails or newsletters, with testing feedback through practice champions. CATTE materials are available at: www.STItraining.eu. PMID:28951413

Improving the fitness and physical activity levels of primary school children: results of the Fit-4-Fun group randomized controlled trial.

PubMed

Eather, Narelle; Morgan, Philip J; Lubans, David R

2013-01-01

To evaluate the impact of a multi-component school-based physical activity intervention (Fit-4-Fun) on health-related fitness and objectively measured physical activity in primary school children. Four Hunter primary schools were recruited in April, 2011 and randomized by school into treatment or control conditions. Participants included 213 children (mean age = 10.72 years ± 0.6; 52.2% female) with the treatment group (n = 118) completing the 8-week Fit-4-Fun Program. Participants were assessed at baseline and 6-month follow-up, with a 91% retention rate. Cardio-respiratory fitness (CRF) (20 m shuttle run) was the primary outcome, and secondary outcomes included body composition (BMI, BMI(Z)), muscular fitness (7-stage sit-up test, push-up test, basketball throw test, Standing Jump), flexibility (sit and reach) and physical activity (7 days pedometry). After 6-months, significant treatment effects were found for CRF (adjusted mean difference, 1.14 levels, p < 0.001), body composition (BMI mean, -0.96 kg/m(2), p < 0.001 and BMI z-score mean -0.47 z-scores, p < 0.001), flexibility (sit and reach mean, 1.52 cm, p = 0.0013), muscular fitness (sit-ups) (mean 0.62 stages, p = 0.003) and physical activity (mean, 3253 steps/day, p < 0.001). There were no group by time effects for the other muscular fitness measures. A primary school-based intervention focusing on fitness education significantly improved health-related fitness and physical activity levels in children. Copyright © 2012 Elsevier Inc. All rights reserved.

Comparison of application of 2013 ACC/AHA guideline and 2011 European Society of Cardiology guideline for the management of dyslipidemias for primary prevention in a Turkish cohort

PubMed Central

Yılmaz, Mustafa; Atar, İlyas; Hasırcı, Senem; Akyol, Kadirhan; Tekin, Abdullah; Karaçağlar, Emir; Çiftçi, Orçun; Müderrisoğlu, Haldun

2017-01-01

Objective: Atherosclerotic cardiovascular disease is a major global cause of death. The common approach in primary prevention of cardiovascular disease is to identify patients at high risk for cardiovascular disease. This article analyzes and compares the application of 2013 American College of Cardiology/American Heart Association (ACC/AHA) guideline and the 2011 European Society of Cardiology (ESC) guideline for the management of dyslipidemias for primary prevention in Turkish population. Methods: The study included 833 patients (482 women and 351 men). Risk scores were calculated according to both guidelines and indications for statin treatment were determined according to sex and age group. Variables are presented as mean±SD or median with interquartile range for continuous data and as proportions for categorical data. Variables were analyzed by unpaired t-test, Mann-Whitney U test, chi-square or Fischer’s exact test as appropriate. Results: The ACC/AHA would suggest statin treatment in 415 patients out of 833 (49.5%), while ESC would recommend statin for 193 patients out of 833 (23.1%) (p<0.001). Statins would be recommended for 40.4% of women and 62.6% of men for primary prevention by the ACC/AHA, while this figure was 12% for women and 38.4% for men according to the ESC guideline (p<0.001 for both). Conclusion: When compared to the ESC guideline, the ACC/AHA guideline suggests augmented statin treatment for primary prevention in Turkish population. PMID:27684519

TMS of supplementary motor area (SMA) facilitates mental rotation performance: Evidence for sequence processing in SMA.

PubMed

Cona, G; Marino, G; Semenza, C

2017-02-01

In the present study we applied online transcranial magnetic stimulation (TMS) bursts at 10Hz to the supplementary motor area (SMA) and primary motor cortex to test whether these regions are causally involved in mental rotation. Furthermore, in order to investigate what is the specific role played by SMA and primary motor cortex, two mental rotation tasks were used, which included pictures of hands and abstract objects, respectively. While primary motor cortex stimulation did not affect mental rotation performance, SMA stimulation improved the performance in the task with object stimuli, and only for the pairs of stimuli that had higher angular disparity between each other (i.e., 100° and 150°). The finding that the effect of SMA stimulation was modulated by the amount of spatial orientation information indicates that SMA is causally involved in the very act of mental rotation. More specifically, we propose that SMA mediates domain-general sequence processes, likely required to accumulate and integrate information that are, in this context, spatial. The possible physiological mechanisms underlying the facilitation of performance due to SMA stimulation are discussed. Copyright © 2016 Elsevier Inc. All rights reserved.

Archetype and object: primary deintegration and primary love in analytical play therapy with young children.

PubMed

Peery, J Craig

2002-07-01

Jungian and post-Jungian theory of the development of the child's psyche is reviewed. A discrimination between primary and secondary deintegration is suggested. Post-Freudian theory regarding primary object relations is integrated with the Jungian model. The two approaches can contribute synergistically to inform and advance play therapy with young children. Patients from widely diverse cultural backgrounds use their relationship with the therapist as a helpful person (object), and engage in archetypal material from the collective unconscious, to help them work on and through their unresolved emotional issues.

U.S. Department of Energy's Regional Carbon Sequestration Partnership Program: Overview

USGS Publications Warehouse

Litynski, J.; Plasynski, S.; Spangler, L.; Finley, R.; Steadman, E.; Ball, D.; Nemeth, K.J.; McPherson, B.; Myer, L.

2009-01-01

The U.S. Department of Energy (DOE) has formed a nationwide network of seven regional partnerships to help determine the best approaches for capturing and permanently storing gases that can contribute to global climate change. The Regional Carbon Sequestration Partnerships (RCSPs) are tasked with determining the most suitable technologies, regulations, and infrastructure for carbon capture, transport, and storage in their areas of the country and parts of Canada. The seven partnerships include more than 350 state agencies, universities, national laboratories, private companies, and environmental organizations, spanning 42 states, two Indian nations, and four Canadian provinces. The Regional Partnerships initiative is being implemented in three phases: ???Characterization Phase (2003-2005): The objective was to collect data on CO2 sources and sinks and develop the human capital to support and enable future carbon sequestration field tests and deployments. The completion of this Phase was marked by release of the Carbon Sequestration Atlas of the United States and Canada-Version 1 which included a common methodology for capacity assessment and reported over 3,000GT of storage capacity in saline formations, depleted oil and gas fields, and coal seams.???Validation Phase (2005-2009): The objective is to plan and implement small-scale (<1??million tons CO2) field testing of storage technologies in areas determined to be favorable for carbon storage. The partnerships are currently conducting over 20 small-scale geologic field tests and 11 terrestrial field tests.???Development Phase (2008-2018): The primary objective is the development of large-scale (>1??million tons of CO2) Carbon Capture and Storage (CCS) projects, which will demonstrate that large volumes of CO2 can be injected safely, permanently, and economically into geologic formations representative of large storage capacity. Even though the RCSP Program is being implemented in three phases, it should be viewed as an integrated whole, with many of the goals and objectives transitioning from one phase to the next. Accomplishments and results from the Characterization Phase have helped to refine goals and activities in the Validation and Deployment Phases. The RCSP Program encourages and requires open information sharing among its members by sponsoring both general workshops and meetings to facilitate information exchange. Although each RCSP has its own objectives and field tests, mutual cooperation has been an important part of the Program thus far. The primary goal of the RCSP initiative is to promote the development of a regional framework and the infrastructure necessary to validate and deploy carbon sequestration technologies within each Partnership's region. ?? 2009 Elsevier Ltd. All rights reserved.

Screening for cognitive impairment in the elderly.

PubMed Central

Bush, C.; Kozak, J.; Elmslie, T.

1997-01-01

OBJECTIVE: To evaluate the extent and type of screening for cognitive impairment primary care physicians use for their elderly patients, to identify perceived barriers to screening, and to explore whether physicians would be willing to use the clock drawing test as a cognitive screening tool. DESIGN: Mailed questionnaire. SETTING: Primary care practices in the Ottawa-Carleton region. PARTICIPANTS: Family physicians and general practitioners culled from the Yellow Pages and Canadian Medical Directory; 368 of 568 questionnaires were returned for a response rate of 70%. Six respondents had fewer than 30 patients weekly and two responded too late to be included in the analysis; 360 cases were included in the analysis. MAIN OUTCOME MEASURES: Responses to 10 questions on cognitive screening and five on demographics and the nature of respondents' practices. RESULTS: About 80% of respondents reported doing at least one mental status examination during the past year. Only 24% routinely screened patients, although 82% believed screening was needed. Major barriers to cognitive screening were lack of time, risk of offending patients, and possible negative consequences of follow up. Clock drawing was perceived as an acceptable method of screening, if it were proven effective. CONCLUSIONS: Most primary care physicians believe cognitive screening is needed, but few routinely screen their elderly patients. Lack of time is the most important perceived barrier to screening. Primary care physicians are receptive to using the clock drawing test, and, because it is not time-consuming, are less likely to consider lack of time a barrier to testing. The clock test might help bridge the gap between perceived need for screening and actual screening. PMID:9356757

Influence of implant diameter in the displacement of dental implants in trabecular bovine bone under a static lateral load: experimental results and computational modeling.

PubMed

Engelke, Wilfried; Decco, Oscar A; Cura, Andrea C; Maldonado, Isai; Crippa, Federico G

2014-12-01

Primary stability and micromovement of dental implants depend on structural properties of the surrounding bone and on implant dimension and design. The purpose of this study was to provide objective data for the influence of implant diameter on the displacement of titanium screw implants. Ninety Semados implants (length 15 mm, diameter 3.25, 3.75, and 4.5 mm; Bego, Bremen, Germany) were inserted in trabecular bone specimens. All implants were inserted with a torque up to 30 N·cm and loaded horizontally with 10, 20, and 30 N for 2 seconds. All implants showed primary stability. With increasing force, a gradual increase of micromovement was observed (Kruskal-Wallis test, P = 0.000). No significant differences were found (Kruskal-Wallis test, P = 0.148) comparing different diameters for every force. Variation of the diameter of standard implants between 3.25 and 4.5 mm does not seem to influence the primary stability in trabecular bone specimen. Differences between experimental and computational results may be due to the simplification used when modeling.

Measuring test productivity - The elusive dream

NASA Astrophysics Data System (ADS)

Ward, D. T.; Cross, E. J., Jr.

1983-11-01

The paper summarizes definitions and terminology relating to measurement of Test and Evaluation productivity before settling on the appropriate criteria for such a measurement model. A productivity measurement scheme suited for use by Test and Evaluation organizations is suggested. This mathematical model is a simplified version of one proposed by the American Productivity Center and applied to an aircraft maintenance facility by Fletcher. It includes only four primary variables: safety, schedule, cost, and deficiencies reported with varying degrees of objectivity and subjectivity involved in quantifying them. A hypothetical example of a fighter aircraft flight test program is used to illustrate the application of the productivity measurement model. The proposed model is intended to serve as a first iteration procedure and should be tested against real test programs to verify and refine it.

Effectiveness of the Epley’s maneuver performed in primary care to treat posterior canal benign paroxysmal positional vertigo: study protocol for a randomized controlled trial

PubMed Central

2014-01-01

Background Vertigo is a common medical condition with a broad spectrum of diagnoses which requires an integrated approach to patients through a structured clinical interview and physical examination. The main cause of vertigo in primary care is benign paroxysmal positional vertigo (BPPV), which should be confirmed by a positive D-H positional test and treated with repositioning maneuvers. The objective of this study is to evaluate the effectiveness of Epley’s maneuver performed by general practitioners (GPs) in the treatment of BPPV. Methods/Design This study is a randomized clinical trial conducted in the primary care setting. The study’s scope will include two urban primary care centers which provide care for approximately 49,400 patients. All patients attending these two primary care centers, who are newly diagnosed with benign paroxysmal positional vertigo, will be invited to participate in the study and will be randomly assigned either to the treatment group (Epley’s maneuver) or to the control group (a sham maneuver). Both groups will receive betahistine. Outcome variables will be: response to the D-H test, patients’ report on presence or absence of vertigo during the previous week (dichotomous variable: yes/no), intensity of vertigo symptoms on a Likert-type scale in the previous week, total score on the Dizziness Handicap Inventory (DHI) and quantity of betahistine taken. We will use descriptive statistics of all variables collected. Groups will be compared using the intent-to-treat approach and either parametric or nonparametric tests, depending on the nature and distribution of the variables. Chi-square test or Fisher’s exact test will be conducted to compare categorical measures and Student’s t-test or Mann–Whitney U-test will be used for intergroup comparison variables. Discussion Positive results from our study will highlight that treatment of benign paroxysmal positional vertigo can be performed by trained general practitioners (GPs) and, therefore, its widespread practice may contribute to improve the quality of life of BPPV patients. Trial registration ClinicalTrials.gov Identifier: NCT01969513. PMID:24886338

49 CFR Appendix B to Part 21 - Activities to Which This Part Applies When a Primary Objective of the Federal Financial...

Code of Federal Regulations, 2013 CFR

2013-10-01

... Primary Objective of the Federal Financial Assistance Is To Provide Employment B Appendix B to Part 21... DEPARTMENT OF TRANSPORTATION-EFFECTUATION OF TITLE VI OF THE CIVIL RIGHTS ACT OF 1964 Pt. 21, App. B Appendix B to Part 21—Activities to Which This Part Applies When a Primary Objective of the Federal Financial...

In Vitro Comparative Analysis of Fracture Resistance in Inlay Restoration Prepared with CAD-CAM and Different Systems in the Primary Teeth

PubMed Central

Derelioglu, Sera

2016-01-01

Objective. The aim of this study was to compare to fracture resistance test of inlay restorations prepared using direct inlay technique (Gradia® Direct Composite) and Indirect Restoration System® (Gradia Indirect Composite) and CAD/CAD system (Vita Enamic® Block). Study Design. 48 noncarious extracted maxillary second primary molars were randomly divided into 4 groups with 12 in each group. All the teeth were prepared based on inlay class II preparations except for the control group. Other groups were restored with Gradia Direct Composite, Gradia Indirect Composite, and Vita Enamic Block, respectively. All restorations were cemented self-adhesive dual cure resin (3M Espe, RelyX™ Unicem Aplicap). A fracture test was performed using a compressive load. Results were analyzed using one-way analysis of variance and Duncan's post hoc multiple comparison tests (α = 0.05). Results. Vita Enamic Block and Gradia Indirect Composite showed significantly higher fracture resistance than Gradia Direct Composite (p < 0.05). There was no significant difference fracture resistance between Vita Enamic Block and Gradia Indirect Composite (p > 0.05). All restorations tested led to a significant reduction in fracture resistance (p < 0.05). Conclusion. In inlay restorations, Indirect Restoration Systems and CAD/CAM systems were applied successfully together with the self-adhesive dual cure resin cements in primary molars. PMID:27830145

OBJECT KINETIC MONTE CARLO SIMULATIONS OF CASCADE ANNEALING IN TUNGSTEN

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nandipati, Giridhar; Setyawan, Wahyu; Heinisch, Howard L.

2014-03-31

The objective of this work is to study the annealing of primary cascade damage created by primary knock-on atoms (PKAs) of various energies, at various temperatures in bulk tungsten using the object kinetic Monte Carlo (OKMC) method.

HIFiRE Direct-Connect Rig (HDCR) Phase I Scramjet Test Results from the NASA Langley Arc-Heated Scramjet Test Facility

NASA Technical Reports Server (NTRS)

Cabell, Karen; Hass, Neal; Storch, Andrea; Gruber, Mark

2011-01-01

A series of hydrocarbon-fueled direct-connect scramjet ground tests has been completed in the NASA Langley Arc-Heated Scramjet Test Facility (AHSTF) at simulated Mach 8 flight conditions. These experiments were part of an initial test phase to support Flight 2 of the Hypersonic International Flight Research Experimentation (HIFiRE) Program. In this flight experiment, a hydrocarbon-fueled scramjet is intended to demonstrate transition from dual-mode to scramjet-mode operation and verify the scramjet performance prediction and design tools A performance goal is the achievement of a combusted fuel equivalence ratio greater than 0.7 while in scramjet mode. The ground test rig, designated the HIFiRE Direct Connect Rig (HDCR), is a full-scale, heat sink test article that duplicates both the flowpath lines and a majority of the instrumentation layout of the isolator and combustor portion of the flight test hardware. The primary objectives of the HDCR Phase I tests were to verify the operability of the HIFiRE isolator/combustor across the simulated Mach 6-8 flight regime and to establish a fuel distribution schedule to ensure a successful mode transition. Both of these objectives were achieved prior to the HiFIRE Flight 2 payload Critical Design Review. Mach 8 ground test results are presented in this report, including flowpath surface pressure distributions that demonstrate the operation of the flowpath in scramjet-mode over a small range of test conditions around the nominal Mach 8 simulation, as well as over a range of fuel equivalence ratios. Flowpath analysis using ground test data is presented elsewhere; however, limited comparisons with analytical predictions suggest that both scramjet-mode operation and the combustion performance objective are achieved at Mach 8 conditions.

Task 4 supporting technology. Densification requirements definition and test objectives. Propellant densification requirements definition

NASA Technical Reports Server (NTRS)

Lak, Tibor; Weeks, D. P.

1995-01-01

The primary challenge of the X-33 CAN is to build and test a prototype LO2 and LH2 densification ground support equipment (GSE) unit, and perform tank thermodynamic testing within the 15 month phase 1 period. The LO2 and LH2 propellant densification system will be scaled for the IPTD LO2 and LH2 tank configurations. The IPTD tanks were selected for the propellant technology demonstration because of the potential benefits to the phase 1 plan: tanks will be built in time to support thermodynamic testing; minimum cost; minimum schedule risk; future testing at MSFC will build on phase 1 data base; and densification system will be available to support X-33 and RLV engine test at IPTD. The objective of the task 1 effort is to define the preliminary requirements of the propellant densification GSE and tank recirculation system. The key densification system design parameters to be established in Task 1 are: recirculation flow rate; heat exchanger inlet temperature; heat exchanger outlet temperature; maximum heat rejection rate; vent flow rate (GN2 and GH2); densification time; and tank pressure level.

Flight Test Results on the Stability and Control of the F-15 Quiet Spike(TradeMark) Aircraft

NASA Technical Reports Server (NTRS)

Moua, Cheng M.; McWherter, Shaun C.; Cox, Timothy H.; Gera, Joe

2012-01-01

The Quiet Spike F-15B flight research program investigated supersonic shock reduction using a 24-ft sub-scale telescoping nose boom on an F-15B airplane. The program primary flight test objective was to collect flight data for aerodynamic and structural models validation up to 1.8 Mach. Other objectives were to validate the mechanical feasibility of a morphing fuselage at the operational conditions and determine the near-field shock wave characterization. The stability and controls objectives were to assess the effect of the spike on the stability, controllability, and handling qualities of the aircraft and to ensure adequate stability margins across the entire research flight envelop. The two main stability and controls issues were the effects of the telescoping nose boom influenced aerodynamics on the F-15B aircraft flight dynamics and air data and angle of attack sensors. This paper reports on the stability and controls flight envelope clearance methods and flight test analysis of the F-15B Quiet Spike. Brief pilot commentary on typical piloting tasks, approach and landing, refueling task, and air data sensitivity to the flight control system are also discussed in this report.

Mini-mast CSI testbed user's guide

NASA Technical Reports Server (NTRS)

Tanner, Sharon E.; Pappa, Richard S.; Sulla, Jeffrey L.; Elliott, Kenny B.; Miserentino, Robert; Bailey, James P.; Cooper, Paul A.; Williams, Boyd L., Jr.; Bruner, Anne M.

1992-01-01

The Mini-Mast testbed is a 20 m generic truss highly representative of future deployable trusses for space applications. It is fully instrumented for system identification and active vibrations control experiments and is used as a ground testbed at NASA-Langley. The facility has actuators and feedback sensors linked via fiber optic cables to the Advanced Real Time Simulation (ARTS) system, where user defined control laws are incorporated into generic controls software. The object of the facility is to conduct comprehensive active vibration control experiments on a dynamically realistic large space structure. A primary goal is to understand the practical effects of simplifying theoretical assumptions. This User's Guide describes the hardware and its primary components, the dynamic characteristics of the test article, the control law implementation process, and the necessary safeguards employed to protect the test article. Suggestions for a strawman controls experiment are also included.

[Chronic diarrhoea: Definition, classification and diagnosis].

PubMed

Fernández-Bañares, Fernando; Accarino, Anna; Balboa, Agustín; Domènech, Eugeni; Esteve, Maria; Garcia-Planella, Esther; Guardiola, Jordi; Molero, Xavier; Rodríguez-Luna, Alba; Ruiz-Cerulla, Alexandra; Santos, Javier; Vaquero, Eva

2016-10-01

Chronic diarrhoea is a common presenting symptom in both primary care medicine and in specialized gastroenterology clinics. It is estimated that >5% of the population has chronic diarrhoea and nearly 40% of these patients are older than 60 years. Clinicians often need to select the best diagnostic approach to these patients and choose between the multiple diagnostic tests available. In 2014 the Catalan Society of Gastroenterology formed a working group with the main objective of creating diagnostic algorithms based on clinical practice and to evaluate diagnostic tests and the scientific evidence available for their use. The GRADE system was used to classify scientific evidence and strength of recommendations. The consensus document contains 28 recommendations and 6 diagnostic algorithms. The document also describes criteria for referral from primary to specialized care. Copyright © 2015 Elsevier España, S.L.U. y AEEH y AEG. All rights reserved.

Primary aldosteronism among newly diagnosed and untreated hypertensive patients in a Swedish primary care area

PubMed Central

Westerdahl, Christina; Bergenfelz, Anders; Isaksson, Anders; Nerbrand, Christina; Valdemarsson, Stig

2011-01-01

Objective To evaluate the prevalence of primary aldosteronism (PA) in newly diagnosed and untreated hypertensive patients in primary care using the aldosterone/renin ratio (ARR), and to assess clinical and biochemical characteristics in patients with high and normal ARR. Design Patient survey study. Setting and subjects A total of 200 consecutive patients with newly diagnosed and untreated hypertension from six primary health care centres in Sweden were included. Main outcome measures ARR was calculated from serum aldosterone and plasma renin concentrations. The cut-off level for ARR was 65. Patients with an increased ARR were considered for confirmatory testing with the fludrocortisone suppression test (FST), followed by adrenal computed tomographic radiology (CT) and adrenal venous sampling (AVS). Results Of 200 patients, 36 patients had an ARR > 65. Of these 36 patients, 11 patients had an incomplete aldosterone inhibition during FST. Three patients were diagnosed with an aldosterone producing adenoma (APA) and eight with bilateral adrenal hyperplasia (BHA). Except for moderately lower level of P-K in patients with an ARR > 65 and in patients with PA, there were no biochemical or clinical differences found among hypertensive patients with PA compared with patients without PA. Conclusion Eleven of 200 evaluated patients (5.5%) were considered to have PA. The diagnosis of PA should therefore be considered in newly diagnosed hypertensive subjects and screening for the diagnosis is warranted. PMID:21323498

Content knowledge of prospective elementary school teacher for fractional concepts

NASA Astrophysics Data System (ADS)

Pattimukay, N.; Juniati, D.; Budiarto, M. T.

2018-03-01

The aim of this study was to describe the content knowledge especially the concept of fraction of prospective elementary school teacher. The purpose of this study is to describe the content knowledge, especially the concept of fraction of prospective elementary school teacher. The subject of the study was one of prospective elementary school teacher of Pattimura University. This research is qualitative research. Data were collected through the provision of tests to explore the knowledge content of primary school teacher candidates about fractional concepts. Then continued with qualitative data analysis. The results of this study are as follows: that the prospective primary school teacher defines fractions as part of the whole if an object is divided into equal parts, so that the part that has been divided is part of the whole. Furthermore, the prospective elementary school teacher understood the fractions as division shown in two ways, namely the prospective elementary school teacher understood the fraction as a division operation, the primary school teacher candidate interpreted the fraction as a division when an object is divided be part of the same. Meanwhile, the fraction as a ratio is interpreted as the relationship between a pair of numbers. Then, the denominations are interpreted as a ratio between the numerator and the denominator of the same value. The prospective elementary school teacher also understands fractions of value when simplifying fractions. Primary school teacher candidates understand the concept of fractional operations.

Determination of end point of primary drying in freeze-drying process control.

PubMed

Patel, Sajal M; Doen, Takayuki; Pikal, Michael J

2010-03-01

Freeze-drying is a relatively expensive process requiring long processing time, and hence one of the key objectives during freeze-drying process development is to minimize the primary drying time, which is the longest of the three steps in freeze-drying. However, increasing the shelf temperature into secondary drying before all of the ice is removed from the product will likely cause collapse or eutectic melt. Thus, from product quality as well as process economics standpoint, it is very critical to detect the end of primary drying. Experiments were conducted with 5% mannitol and 5% sucrose as model systems. The apparent end point of primary drying was determined by comparative pressure measurement (i.e., Pirani vs. MKS Baratron), dew point, Lyotrack (gas plasma spectroscopy), water concentration from tunable diode laser absorption spectroscopy, condenser pressure, pressure rise test (manometric temperature measurement or variations of this method), and product thermocouples. Vials were pulled out from the drying chamber using a sample thief during late primary and early secondary drying to determine percent residual moisture either gravimetrically or by Karl Fischer, and the cake structure was determined visually for melt-back, collapse, and retention of cake structure at the apparent end point of primary drying (i.e., onset, midpoint, and offset). By far, the Pirani is the best choice of the methods tested for evaluation of the end point of primary drying. Also, it is a batch technique, which is cheap, steam sterilizable, and easy to install without requiring any modification to the existing dryer.

Breast Retraction Assessment: an objective evaluation of cosmetic results of patients treated conservatively for breast cancer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pezner, R.D.; Patterson, M.P.; Hill, L.R.

Breast Retraction Assessment (BRA) is an objective evaluation of the amount of cosmetic retraction of the treated breast in comparison to the untreated breast in patients who receive conservative treatment for breast cancer. A clear acrylic sheet supported vertically and marked as a grid at 1 cm intervals is employed to perform the measurements. Average BRA value in 29 control patients without breast cancer was 1.2 cm. Average BRA value in 27 patients treated conservatively for clinical Stage I or II unilateral breast cancer was 3.7 cm. BRA values in breast cancer patients ranged from 0.0 to 8.5 cm. Patientsmore » who received a local radiation boost to the primary tumor bed site had statistically significantly less retraction than those who did not receive a boost. Patients who had an extensive primary tumor resection had statistically significantly more retraction than those who underwent a more limited resection. In comparison to qualitative forms of cosmetic analysis, BRA is an objective test that can quantitatively evaluate factors which may be related to cosmetic retraction in patients treated conservatively for breast cancer.« less

Comparison of cytology, HPV DNA testing and HPV 16/18 genotyping alone or combined targeting to the more balanced methodology for cervical cancer screening.

PubMed

Chatzistamatiou, Kimon; Moysiadis, Theodoros; Moschaki, Viktoria; Panteleris, Nikolaos; Agorastos, Theodoros

2016-07-01

The objective of the present study was to identify the most effective cervical cancer screening algorithm incorporating different combinations of cytology, HPV testing and genotyping. Women 25-55years old recruited for the "HERMES" (HEllenic Real life Multicentric cErvical Screening) study were screened in terms of cytology and high-risk (hr) HPV testing with HPV 16/18 genotyping. Women positive for cytology or/and hrHPV were referred for colposcopy, biopsy and treatment. Ten screening algorithms based on different combinations of cytology, HPV testing and HPV 16/18 genotyping were investigated in terms of diagnostic accuracy. Three clusters of algorithms were formed according to the balance between effectiveness and harm caused by screening. The cluster showing the best balance included two algorithms based on co-testing and two based on HPV primary screening with HPV 16/18 genotyping. Among these, hrHPV testing with HPV 16/18 genotyping and reflex cytology (atypical squamous cells of undetermined significance - ASCUS threshold) presented the optimal combination of sensitivity (82.9%) and specificity relative to cytology alone (0.99) with 1.26 false positive rate relative to cytology alone. HPV testing with HPV 16/18 genotyping, referring HPV 16/18 positive women directly to colposcopy, and hrHPV (non 16/18) positive women to reflex cytology (ASCUS threshold), as a triage method to colposcopy, reflects the best equilibrium between screening effectiveness and harm. Algorithms, based on cytology as initial screening method, on co-testing or HPV primary without genotyping, and on HPV primary with genotyping but without cytology triage, are not supported according to the present analysis. Copyright © 2016 Elsevier Inc. All rights reserved.

Effects of Direct-to-Consumer Advertising and Clinical Guidelines on Appropriate Use of Human Papillomavirus DNA Tests

PubMed Central

2011-01-01

Background Both clinical guidelines and direct-to-consumer (DTC) advertising influence use of new health care technologies, but little is known about their relative effects. The introduction of a cervical cancer screening test in 2000 offered a unique opportunity to assess the two strategies. Objective To evaluate the effects of clinical guidelines and a targeted DTC advertising campaign on overall and appropriate use of human papillomavirus (HPV) DNA tests. Research Design Quasi-experimental study using difference-in-differences analysis. Data were MarketScan private insurance claims for 500,000 women ages 21 to 64 enrolled at least 12 consecutive months from January 2001 through December 2005. Results Both clinical guidelines and DTC advertising were associated with increases in overall HPV DNA test use. DTC advertising was associated with a statistically significant increase in HPV DNA test use in two groups of DTC cities (+5.57 percent, p<0.0001; +2.54 percent, p<0.0001). DTC advertising was associated with comparable increases in the probability of appropriate and inappropriate use of the HPV DNA test in primary screening. Clinical guideline releases from the American College of Obstetricians and Gynecologists, and by a co-sponsored panel, were associated with greater increases in HPV DNA tests for appropriate primary screening than for inappropriate primary screening (β=0.3347, p<0.05 and β=0.4175, p<0.01). Conclusions DTC advertising was associated with increased overall use of a cervical cancer screening test, while clinical guidelines were differentially associated with increased appropriate use. These findings suggest distinct influences of consumer marketing and professional guidelines on the use of health care products and services. PMID:21150798

Results of an investigation of jet plume effects on a 0.010-scale model (75-OTS) of the space shuttle integrated vehicle in the 8 x 7-foot leg of the NASA/Ames unitary wind tunnel (IA82C), volume 1. [(an exhaust flow simulation)

NASA Technical Reports Server (NTRS)

Hawthorne, P. J.

1976-01-01

The primary test objective was to define the base pressure environment of the first and second stage mated vehicle in a supersonic flow field from Mach 2.60 through 3.50 with simulated rocket engine exhaust plumes. The secondary objective was to obtain the pressure environment of the Orbiter at various vent port locations at these same freestream conditions. Data were obtained at angles of attack from -4 deg through +4 deg at zero yaw, and at yaw angles from -4 deg through +4 deg at zero angle of attack, with rocket plume sizes varying from smaller than nominal to much greater than nominal. Failed Orbiter engine data were also obtained. Elevon hinge moments and wing panel load data were obtained during all runs. Photographs of test equipment and tested configurations are shown.

Low Speed Wind Tunnel Tests on a One-Seventh Scale Model of the H.126 Jet Flap Aircraft

NASA Technical Reports Server (NTRS)

Laub, G. H.

1975-01-01

Low speed wind tunnel tests were performed on a one-seventh scale model of the British H.126 jet flap research aircraft over a range of jet momentum coefficients. The primary objective was to compare model aerodynamic characteristics with those of the aircraft, with the intent to provide preliminary data needed towards establishing small-to-full scale correlating techniques on jet flap V/STOL aircraft configurations. Lift and drag coefficients from the model and aircraft tests were found to be in reasonable agreement. The pitching moment coefficient and trim condition correlation was poor. A secondary objective was to evaluate a modified thrust nozzle having thrust reversal capability. The results showed there was a considerable loss of lift in the reverse thrust operational mode because of increased nozzle-wing flow interference. A comparison between the model simulated H.126 wing jet efflux and the model uniform pressure distribution wing jet efflux indicated no more than 5% loss in weight flow rate.

Design and development of FZU-32/B bomb fuze initiator. Final report 23 Jun 72--15 Nov 73

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miazza, J.

1974-05-01

The primary objective of this program was to develop a cost effective, production engineered FZU-24/B Bomb Fuze Initiator. The initiator is an electric generating device which, when installed in the fuze charging well of general purpose bombs, is capable of deriving energy from the airstream passing the bomb in free fall and converting the energy into electric energy suitable for powering a bomb fuze. The objective was to be accomplished by means of a production engineering effort carried through the evolution of design, fabrication, assembly, test, and evaluation. The baseline for the design was Harry Diamond Laboratories' Drawing No. 11716160.more » A quantity of 60 units was fabricated and tested, in accordance with the production engineered design. After some additional redesign to correct identified deficiencies, 220 units were fabricated. These units were subjected to environmental, wind tunnel, and flight testing and performance requirements were met. The final unit design was designated the FZU-32/B Bomb Fuze Initiator.« less

Results of a landing gear loads test using a 0.0405-scale model (16-0) of the space shuttle orbiter in the Rockwell International NAAL wind tunnel (OA163), volume 1

NASA Technical Reports Server (NTRS)

Mennell, R. C.

1976-01-01

Experimental aerodynamic investigations were conducted on a sting mounted scale representation of the 140C outer mold line space shuttle orbiter configuration in the low speed wind tunnel. The primary test objectives were to define the orbiter landing gear system pressure loading and to record landing gear door and strut hingemoment levels. Secondary objectives included recording the aerodynamic influence of various landing gear configurations on orbiter force data as well as investigating 40 x 80 ft. Ames Wind Tunnel strut simulation effects on both orbiter landing gear loads and aerodynamic characteristics. Testing was conducted at a Mach number of 0.17, free stream dynamic pressure of 42.5 PSF, and Reynolds number per unit length of 1.2 million per foot. Angle of attack variation was 0 to 20 while yaw angles ranged from -10 to 10 deg.

Cancer patients' perceptions regarding the value of the physical examination: a survey study.

PubMed

Kadakia, Kunal C; Hui, David; Chisholm, Gary B; Frisbee-Hume, Susan E; Williams, Janet L; Bruera, Eduardo

2014-07-15

Despite its clinical utility, progressive reliance on technology can lead to devaluing the physical examination in patients with advanced cancer. The primary objective of this study was to determine whether these patients have a positive or negative perception of the physical examination. A secondary objective was to determine whether these perceptions are related to interpersonal/relational values (symbolic) or diagnostic/objective values (pragmatic). One hundred fifty patients with cancer who were receiving concurrent oncology and palliative care were administered a 26-item survey regarding their overall perception of the physical examination. The primary outcome-patient responses to "In the last 3 months, I believe my experience while being examined has been overall: very negative (a score of -5) to very positive (a score of +5),"-was analyzed using the Sign test. Other items were predefined as either symbolic or pragmatic statements, and patient responses from strongly disagree (a score of 1) to strongly agree (a score of 5) were further analyzed. Multivariable logistic regression was used to test for associations between baseline characteristics and the primary outcome. Most patients (83%) indicated that the overall experience of being examined was highly positive (median score, 4; interquartile range [IQR], 2-5; P ≤ .0001). Patients valued both the pragmatic aspects (median score, 5; IQR, 4-5) and symbolic aspects (median score, 4; IQR, 4-5) of the physical examination. Increasing age was independently associated with a more positive perception of the physical examination (odds ratio, 1.07 per year; 95% confidence interval, 1.02-1.12 per year; P = .01). Patients with advanced cancer indicate that the physical examination is a highly positive aspect of their care. These benefits are perceived as having both symbolic and pragmatic value. The physical examination should remain a cornerstone of clinical encounters. © 2014 American Cancer Society.

The Development and Testing of a Model for a Nationally Based Vehicle Dedicated to the Continuing Professional Growth of School Administrators. Final Report.

ERIC Educational Resources Information Center

Knezevich, Stephen J.

The primary objectives of the study were to develop a model for a National Academy for School Executives (NASE), to determine the receptivity of school administrators to such a program, and to determine the feasibility of implementing the model within the near future. Four academic task forces studied the structural elements, fiscal requirements,…

Applications and Methods for Continuous Monitoring of Physiological Chemistry

DTIC Science & Technology

2016-02-04

product and test platform to verify the performance characteristics of the enzymes when used in diagnostic device fabrication. 1.3 Results This...project had three primary objectives: 1. Engineer a cortisol oxidase enzyme suitable for use in diagnostic devices 2. Large scale production and...for both animal and human use , and for direct sale to other entities to manufacture biosensors and other products for human monitoring. The enzymes

Saturn Apollo Program

NASA Image and Video Library

1968-10-01

AS-205, the fifth Saturn IB launch vehicle developed by the Marshall Space Flight Center (MSFC), lifts off from Cape Canaveral, Florida on the first marned Apollo-Saturn mission, Apollo 7. Primary mission objectives included demonstration of the Apollo crew (Walter Schirra, Don Eisele, and Walter Cunningham) capabilities and the Command/Service Module rendezvous capability. In all, nine Saturn IB flights were made, ending with the Apollo-Soyuz Test Project in July 1975.

Quick Assessment of Literacy in Primary Care: The Newest Vital Sign

PubMed Central

Weiss, Barry D.; Mays, Mary Z.; Martz, William; Castro, Kelley Merriam; DeWalt, Darren A.; Pignone, Michael P.; Mockbee, Joy; Hale, Frank A.

2005-01-01

PURPOSE Current health literacy screening instruments for health care settings are either too long for routine use or available only in English. Our objective was to develop a quick and accurate screening test for limited literacy available in English and Spanish. METHODS We administered candidate items for the new instrument and also the Test of Functional Health Literacy in Adults (TOFHLA) to English-speaking and Spanish-speaking primary care patients. We measured internal consistency with Cronbach’s α and assessed criterion validity by measuring correlations with TOFHLA scores. Using TOFLHA scores <75 to define limited literacy, we plotted receiver-operating characteristics (ROC) curves and calculated likelihood ratios for cutoff scores on the new instrument. RESULTS The final instrument, the Newest Vital Sign (NVS), is a nutrition label that is accompanied by 6 questions and requires 3 minutes for administration. It is reliable (Cronbach α >0.76 in English and 0.69 in Spanish) and correlates with the TOFHLA. Area under the ROC curve is 0.88 for English and 0.72 for Spanish versions. Patients with more than 4 correct responses are unlikely to have low literacy, whereas fewer than 4 correct answers indicate the possibility of limited literacy. CONCLUSION NVS is suitable for use as a quick screening test for limited literacy in primary health care settings. PMID:16338915

Advances in the quantification of mitochondrial function in primary human immune cells through extracellular flux analysis.

PubMed

Nicholas, Dequina; Proctor, Elizabeth A; Raval, Forum M; Ip, Blanche C; Habib, Chloe; Ritou, Eleni; Grammatopoulos, Tom N; Steenkamp, Devin; Dooms, Hans; Apovian, Caroline M; Lauffenburger, Douglas A; Nikolajczyk, Barbara S

2017-01-01

Numerous studies show that mitochondrial energy generation determines the effectiveness of immune responses. Furthermore, changes in mitochondrial function may regulate lymphocyte function in inflammatory diseases like type 2 diabetes. Analysis of lymphocyte mitochondrial function has been facilitated by introduction of 96-well format extracellular flux (XF96) analyzers, but the technology remains imperfect for analysis of human lymphocytes. Limitations in XF technology include the lack of practical protocols for analysis of archived human cells, and inadequate data analysis tools that require manual quality checks. Current analysis tools for XF outcomes are also unable to automatically assess data quality and delete untenable data from the relatively high number of biological replicates needed to power complex human cell studies. The objectives of work presented herein are to test the impact of common cellular manipulations on XF outcomes, and to develop and validate a new automated tool that objectively analyzes a virtually unlimited number of samples to quantitate mitochondrial function in immune cells. We present significant improvements on previous XF analyses of primary human cells that will be absolutely essential to test the prediction that changes in immune cell mitochondrial function and fuel sources support immune dysfunction in chronic inflammatory diseases like type 2 diabetes.

NSTAR Ion Thruster and Breadboard Power Processor Functional Integration Test Results

NASA Technical Reports Server (NTRS)

Hamley, John A.; Pinero, Luis R.; Rawlin, Vincent K.; Miller, John R.; Myers, Roger M.; Bowers, Glen E.

1996-01-01

A 2.3 kW Breadboard Power Processing Unit (BBPPU) was developed as part of the NASA Solar Electric Propulsion Technology Application Readiness (NSTAR) Program. The NSTAR program will deliver an electric propulsion system based on a 30 cm xenon ion thruster to the New Millennium (NM) program for use as the primary propulsion system for the initial NM flight. The final development test for the BBPPU, the Functional Integration Test, was carried out to demonstrate all aspects of BBPPU operation with an Engineering Model Thruster. Test objectives included: (1) demonstration and validation of automated thruster start procedures, (2) demonstration of stable closed loop control of the thruster beam current, (3) successful response and recovery to thruster faults, and (4) successful safing of the system during simulated spacecraft faults. These objectives were met over the specified 80-120 VDC input voltage range and 0.5-2.3 output power capability of the BBPPU. Two minor anomalies were noted in discharge and neutralizer keeper current. These anomalies did not affect the stability of the system and were successfully corrected.

Subjective and Objective Measures of Dryness Symptoms in Primary Sjögren's Syndrome: Capturing the Discrepancy.

PubMed

Bezzina, Oriana M; Gallagher, Peter; Mitchell, Sheryl; Bowman, Simon J; Griffiths, Bridget; Hindmarsh, Victoria; Hargreaves, Ben; Price, Elizabeth J; Pease, Colin T; Emery, Paul; Lanyon, Peter; Bombardieri, Michele; Sutcliffe, Nurhan; Pitzalis, Costantino; Hunter, John; Gupta, Monica; McLaren, John; Cooper, Anne M; Regan, Marian; Giles, Ian P; Isenberg, David A; Saravanan, Vadivelu; Coady, David; Dasgupta, Bhaskar; McHugh, Neil J; Young-Min, Steven A; Moots, Robert J; Gendi, Nagui; Akil, Mohammed; MacKay, Kirsten; Ng, W Fai; Robinson, Lucy J

2017-11-01

To develop a novel method for capturing the discrepancy between objective tests and subjective dryness symptoms (a sensitivity scale) and to explore predictors of dryness sensitivity. Archive data from the UK Primary Sjögren's Syndrome Registry (n = 688) were used. Patients were classified on a scale from -5 (stoical) to +5 (sensitive) depending on the degree of discrepancy between their objective and subjective symptoms classes. Sensitivity scores were correlated with demographic variables, disease-related factors, and symptoms of pain, fatigue, anxiety, and depression. Patients were on average relatively stoical for both types of dryness symptoms (mean ± SD ocular dryness -0.42 ± 2.2 and -1.24 ± 1.6 oral dryness). Twenty-seven percent of patients were classified as sensitive to ocular dryness and 9% to oral dryness. Hierarchical regression analyses identified the strongest predictor of ocular dryness sensitivity to be self-reported pain and that of oral dryness sensitivity to be self-reported fatigue. Ocular and oral dryness sensitivity can be classified on a continuous scale. The 2 symptom types are predicted by different variables. A large number of factors remain to be explored that may impact symptom sensitivity in primary Sjögren's syndrome, and the proposed method could be used to identify relatively sensitive and stoical patients for future studies. © 2016, The Authors. Arthritis Care & Research published by Wiley Periodicals, Inc. on behalf of American College of Rheumatology.

Pilot of integrated, colocated neurology in a primary care medical home.

PubMed

Young, Nathan P; Elrashidi, Muhamad Y; Crane, Sarah J; Ebbert, Jon O

2017-06-01

Novel health care delivery models are needed to reduce health care use while delivering effective and safe care. We developed a model of a neurologist integrated and colocated in primary care leveraging "curbside," electronic, and traditional consultations. Our objective was to examine the impact on health care resource use of diagnostic testing and referrals for face-to-face neurological consultation and adverse outcomes associated with electronic and curbside consultations. Consecutive patients from December 1, 2014, to March 13, 2015, were included in the analysis about whom contact was made between a primary care clinician and a colocated neurologist. Over 3.5 months of the pilot, 359 unique patients generated 429 consultations (179 curbsides, 68 electronic consultations, and 182 face-to-face visits). The integrated model resulted in avoidance of 78 face-to-face tertiary neurology consultations, 39 brain magnetic resonance imaging, 50 electromyograms, and 53 other advanced imaging studies. Earlier curbside consultation may have prevented unnecessary testing or face-to-face tertiary neurology consultations in 40 (22%) patients. Earlier face-to-face consultation may have avoided expensive testing in 31 (17%) patients. No cases met criteria for an adverse outcome. The number of referrals to tertiary neurology declined by 64%, and the total number of face-to-face visits per month declined by 25%. Colocated neurology in a primary care medical home offers a promising intervention to deliver high-value care. © 2016 John Wiley & Sons, Ltd.

Discrete memory impairments in largely pure chronic users of MDMA.

PubMed

Wunderli, Michael D; Vonmoos, Matthias; Fürst, Marina; Schädelin, Katrin; Kraemer, Thomas; Baumgartner, Markus R; Seifritz, Erich; Quednow, Boris B

2017-10-01

Chronic use of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") has repeatedly been associated with deficits in working memory, declarative memory, and executive functions. However, previous findings regarding working memory and executive function are inconclusive yet, as in most studies concomitant stimulant use, which is known to affect these functions, was not adequately controlled for. Therefore, we compared the cognitive performance of 26 stimulant-free and largely pure (primary) MDMA users, 25 stimulant-using polydrug MDMA users, and 56 MDMA/stimulant-naïve controls by applying a comprehensive neuropsychological test battery. Neuropsychological tests were grouped into four cognitive domains. Recent drug use was objectively quantified by 6-month hair analyses on 17 substances and metabolites. Considerably lower mean hair concentrations of stimulants (amphetamine, methamphetamine, methylphenidate, cocaine), opioids (morphine, methadone, codeine), and hallucinogens (ketamine, 2C-B) were detected in primary compared to polydrug users, while both user groups did not differ in their MDMA hair concentration. Cohen's d effect sizes for both comparisons, i.e., primary MDMA users vs. controls and polydrug MDMA users vs. controls, were highest for declarative memory (d primary =.90, d polydrug =1.21), followed by working memory (d primary =.52, d polydrug =.96), executive functions (d primary =.46, d polydrug =.86), and attention (d primary =.23, d polydrug =.70). Thus, primary MDMA users showed strong and relatively discrete declarative memory impairments, whereas MDMA polydrug users displayed broad and unspecific cognitive impairments. Consequently, even largely pure chronic MDMA use is associated with decreased performance in declarative memory, while additional deficits in working memory and executive functions displayed by polydrug MDMA users are likely driven by stimulant co-use. Copyright © 2017 Elsevier B.V. and ECNP. All rights reserved.

The reliability and validity of a Japanese version of symptom checklist 90 revised

PubMed Central

Tomioka, Mitsunao; Shimura, Midori; Hidaka, Mikio; Kubo, Chiharu

2008-01-01

Objective To examine the validity and reliability of a Japanese version of the Symptom Checklist 90 Revised (SCL-90-R (J)). Methods The English SCL-90-R was translated to Japanese and the Japanese version confirmed by back-translation. To determine the factor validity and internal consistency of the nine primary subscales, 460 people from the community completed SCL-90-R(J). Test-retest reliability was examined for 104 outpatients and 124 healthy undergraduate students. The convergent-discriminant validity was determined for 80 inpatients who replied to both SCL-90-R(J) and the Minnesota Multiphasic Personality Inventory (MMPI). Results The correlation coefficients between the nine primary subscales and items were .26 to .78. Cronbach's alpha coefficients were from .76 (Phobic Anxiety) to .86 (Interpersonal Sensitivity). Pearson's correlation coefficients between test-retest scores were from .81 (Psychoticism) to .90 (Somatization) for the outpatients and were from .64 (Phobic Anxiety) to .78 (Paranoid Ideation) for the students. Each of the nine primary subscales correlated well with their corresponding constructs in the MMPI. Conclusion We confirmed the validity and reliability of SCL-90-R(J) for the measurement of individual distress. The nine primary subscales were consistent with the items of the original English version. PMID:18957078

Real-time tracking of objects for a KC-135 microgravity experiment

NASA Technical Reports Server (NTRS)

Littlefield, Mark L.

1994-01-01

The design of a visual tracking system for use on the Extra-Vehicular Activity Helper/Retriever (EVAHR) is discussed. EVAHR is an autonomous robot designed to perform numerous tasks in an orbital microgravity environment. Since the ability to grasp a freely translating and rotating object is vital to the robot's mission, the EVAHR must analyze range image generated by the primary sensor. This allows EVAHR to locate and focus its sensors so that an accurate set of object poses can be determined and a grasp strategy planned. To test the visual tracking system being developed, a mathematical simulation was used to model the space station environment and maintain dynamics on the EVAHR and any other free floating objects. A second phase of the investigation consists of a series of experiments carried out aboard a KC-135 aircraft flying a parabolic trajectory to simulate microgravity.

Next-generation avionics packaging and cooling 'test results from a prototype system'

NASA Astrophysics Data System (ADS)

Seals, J. D.

The author reports on the design, material characteristics, and test results obtained under the US Air Force's advanced aircraft avionics packaging technologies (AAAPT) program, whose charter is to investigate new designs and technologies for reliable packaging, interconnection, and thermal management. Under this program, AT&T Bell Laboratories has completed the preliminary testing of and is evaluating a number of promising materials and technologies, including conformal encapsulation, liquid flow-through cooling, and a cyanate ester backplane. A fifty-two module system incorporating these and and other technologies has undergone preliminary cooling efficiency, shock, sine and random vibration, and maintenance testing. One of the primary objectives was to evaluate the interaction compatibility of new materials and designs with other components in the system.

Resource Prospector Propulsion Cold Flow Test

NASA Technical Reports Server (NTRS)

Williams, Hunter; Pederson, Kevin; Dervan, Melanie; Holt, Kimberly; Jernigan, Frankie; Trinh, Huu; Flores, Sam

2014-01-01

For the past year, NASA Marshall Space Flight Center and Johnson Space Center have been working on a government version of a lunar lander design for the Resource Prospector Mission. A propulsion cold flow test system, representing an early flight design of the propulsion system, has been fabricated. The primary objective of the cold flow test is to simulate the Resource Prospector propulsion system operation through water flow testing and obtain data for anchoring analytical models. This effort will also provide an opportunity to develop a propulsion system mockup to examine hardware integration to a flight structure. This paper will report the work progress of the propulsion cold flow test system development and test preparation. At the time this paper is written, the initial waterhammer testing is underway. The initial assessment of the test data suggests that the results are as expected and have a similar trend with the pretest prediction. The test results will be reported in a future conference.

Infrared Imagery of Solid Rocket Exhaust Plumes

NASA Technical Reports Server (NTRS)

Moran, Robert P.; Houston, Janice D.

2011-01-01

The Ares I Scale Model Acoustic Test program consisted of a series of 18 solid rocket motor static firings, simulating the liftoff conditions of the Ares I five-segment Reusable Solid Rocket Motor Vehicle. Primary test objectives included acquiring acoustic and pressure data which will be used to validate analytical models for the prediction of Ares 1 liftoff acoustics and ignition overpressure environments. The test article consisted of a 5% scale Ares I vehicle and launch tower mounted on the Mobile Launch Pad. The testing also incorporated several Water Sound Suppression Systems. Infrared imagery was employed during the solid rocket testing to support the validation or improvement of analytical models, and identify corollaries between rocket plume size or shape and the accompanying measured level of noise suppression obtained by water sound suppression systems.

COVER Project and Earth resources research transition

NASA Technical Reports Server (NTRS)

Botkin, D. B.; Estes, J. E. (Principal Investigator)

1986-01-01

Results of research in the remote sensing of natural boreal forest vegetation (the COVER project) are summarized. The study objectives were to establish a baseline forest test site; develop transforms of LANDSAT MSS and TM data for forest composition, biomass, leaf area index, and net primary productivity; and perform tasks required for testing hypotheses regarding observed spectral responses to changes in leaf area index in aspen. In addition, the transfer and documentation of data collected in the COVER project (removed from the Johnson Space Center following the discontinuation of Earth resources research at that facility) is described.

Final Report: System Reliability Model for Solid-State Lighting (SSL) Luminaires

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davis, J. Lynn

2017-05-31

The primary objectives of this project was to develop and validate reliability models and accelerated stress testing (AST) methodologies for predicting the lifetime of integrated SSL luminaires. This study examined the likely failure modes for SSL luminaires including abrupt failure, excessive lumen depreciation, unacceptable color shifts, and increased power consumption. Data on the relative distribution of these failure modes were acquired through extensive accelerated stress tests and combined with industry data and other source of information on LED lighting. This data was compiled and utilized to build models of the aging behavior of key luminaire optical and electrical components.

JWST and Exoplanets

NASA Technical Reports Server (NTRS)

Mather, John C.

2009-01-01

The James Webb Space Telescope is on track for a launch in 2013. The author reviews the status and progress on the key hardware. The first primary mirror segments are already at MSFC for cryogenic tests, the mid IR instrument (MIRI) has already had successful tests of the engineering model, and the detectors are showing excellent performance. The author also describes the scientific objectives of the mission, with emphasis on the predicted capabilities for observing planets by the transit technique and through direct imaging. Recent direct observations of planets by HST and by adaptive optics from the ground have shown that, under favorable circumstances, much can be learned.

The Impact of Sleep-Related Attentional Bias on Polysomnographically Measured Sleep in Primary Insomnia

PubMed Central

Spiegelhalder, Kai; Kyle, Simon D.; Feige, Bernd; Prem, Martin; Nissen, Christoph; Espie, Colin A.; Riemann, Dieter

2010-01-01

Study Objectives: Although sleep-related attentional bias has been shown to be evident in primary insomnia, the association with objectively measured sleep has not been investigated. In the present study, we used polysomnography (PSG) to fill this void. Design: Patients with primary insomnia and healthy controls were studied using a visual dot probe task (VDP) and an emotional Stroop task (EST). Additionally, polysomnography was carried out in a sub-sample (n = 22) of patients in the subsequent night. Setting: Department of Psychiatry and Psychotherapy of the University of Freiburg Medical Center. Participants: Thirty patients with primary insomnia and 30 matched healthy controls. Interventions: N/A Measurements and Results: Patients with primary insomnia demonstrated a significant sleep-related attentional bias compared to controls in the EST but no significant group effects were found for the VDP. VDP attentional bias scores were positively correlated with measures of sleep pressure, including total sleep time, sleep efficiency, and the amount of slow wave sleep. EST attentional bias scores were not correlated with subsequent PSG parameters, and we did not observe a correlation between attentional bias scores on the two tasks. Conclusions: The unexpected relationship between increased attentional bias, in the VDP task, and improved markers of sleep duration and continuity, may be indicative of a homeostatic craving for sleep in those with high attentional bias. This awaits further testing in multiple night studies, to shed light on the mechanisms and implications of sleep-related attentional bias. Citation: Spiegelhalder K; Kyle SD; Feige B; Prem M; Nissen C; Espie CA; Riemann D. The impact of sleep-related attentional bias on polysomnographically measured sleep in primary insomnia. SLEEP 2010;33(1):107-112. PMID:20120627

Evolution of cervical cancer screening and prevention in United States and Canada: Implications for public health practitioners and clinicians☆,☆☆

PubMed Central

Saraiya, M.; Steben, M.; Watson, M.; Markowitz, L.

2015-01-01

Objective Declines in cervical cancer incidence and mortality in Canada and in the United States have been widely attributed to the introduction of the Papanicolaou (Pap) test. This article reviews changes in screening and introduction of HPV vaccination. Method Sentinel events in cervical cancer screening and primary prevention through HPV vaccination in the US and Canada are described. Results Despite commonalities, cervical cancer screening and prevention differ between the two countries. Canada has a combination of opportunistic and organized programs at the provincial and territorial level, while the US has opportunistic screening and vaccination systems. In the US, the HPV test along with the Pap test (co-testing) is part of national recommendations for routine cervical cancer screening for women age 30 and older. Co-testing is not being considered anywhere in Canada, but primary HPV testing is currently recommended (but not implemented) in one province in Canada. Conclusion Many prevention strategies are available for cervical cancer. Continued public health efforts should focus on increasing vaccine coverage in the target age groups and cervical cancer screening for women at appropriate intervals. Ongoing evaluation will be needed to ensure appropriate use of health resources, as vaccinated women become eligible for screening. PMID:23402963

Fatigue life prediction of bonded primary joints

NASA Technical Reports Server (NTRS)

Knauss, J. F.

1979-01-01

The validation of a proposed fatigue life prediction methodology was sought through the use of aluminum butt and scarf joint and graphite/epoxy butt joint specimens in a constant amplitude fatigue environment. The structural properties of the HYSOL 9313 adhesive system were obtained by mechanical test of molded heat adhesive specimens. Aluminum contoured double cantilever beam specimens were used to generate crack velocity versus stress intensity factor data. The specific objectives were: (1) to ascertain the feasibility of predicting fatigue failure of an adhesive in a primary bonded composite structure by incorporating linear elastic crack growth behavior; and (2) to ascertain if acoustic emission and/or compliance measurement techniques can be used to detect flaws.

Increase in antibiotic prescriptions in out-of-hours primary care in contrast to in-hours primary care prescriptions: service evaluation in a population of 600 000 patients

PubMed Central

Hayward, G. N.; Fisher, R. F. R.; Spence, G. T.; Lasserson, D. S.

2016-01-01

Objectives The objective of this study was to describe the frequency and nature of antibiotic prescriptions issued by a primary care out-of-hours (OOH) service and compare time trends in prescriptions between OOH and in-hours primary care. Methods We performed a retrospective audit of 496 931 patient contacts with the Oxfordshire OOH primary care service. Comparison of time trends in antibiotic prescriptions from OOH primary care and in-hours primary care for the same population was made using multiple linear regression models fitted to the monthly data for OOH prescriptions, OOH contacts and in-hours prescriptions between September 2010 and August 2014. Results Compared with the overall population contacting the OOH service, younger age, female sex and patients who were less deprived were independently correlated with an increased chance of a contact resulting in prescription of antibiotics. The majority of antibiotics were prescribed to patients contacting the service at weekends. Despite a reduction in patient contacts with the OOH service [an estimated decrease of 486.5 monthly contacts each year (95% CI −676.3 to −296.8), 5.0% of the average monthly contacts], antibiotic prescriptions from this service rose during the study period [increase of 37.1 monthly prescriptions each year (95% CI 10.6–63.7), 2.5% of the average monthly prescriptions]. A matching increase was not seen for in-hours antibiotic prescriptions; the difference between the year trends was significant (Z test, P = 0.002). Conclusions We have demonstrated trends in prescribing that could represent a partial displacement of antibiotic prescribing from in-hours to OOH primary care. The possibility that the trends we describe are evident nationally should be explored. PMID:27287234

Hanford's Supplemental Treatment Project: Full-Scale Integrated Testing of In-Container-Vitrification and a 10,000-Liter Dryer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Witwer, K.S.; Dysland, E.J.; Garfield, J.S.

2008-07-01

The GeoMelt{sup R} In-Container Vitrification{sup TM} (ICV{sup TM}) process was selected by the U.S. Department of Energy (DOE) in 2004 for further evaluation as the supplemental treatment technology for Hanford's low-activity waste (LAW). Also referred to as 'bulk vitrification', this process combines glass forming minerals, LAW, and chemical amendments; dries the mixture; and then vitrifies the material in a refractory-lined steel container. AMEC Nuclear Ltd. (AMEC) is adapting its GeoMelt ICV{sup TM} technology for this application with technical and analytical support from Pacific Northwest National Laboratory (PNNL). The DVBS project is funded by the DOE Office of River Protection andmore » administered by CH2M HILL Hanford Group, Inc. The Demonstration Bulk Vitrification Project (DBVS) was initiated to engineer, construct, and operate a full-scale bulk vitrification pilot-plant to treat up to 750,000 liters of LAW from Waste Tank 241-S-109 at the DOE Hanford Site. Since the beginning of the DBVS project in 2004, testing has used laboratory, crucible-scale, and engineering-scale equipment to help establish process limitations of selected glass formulations and identify operational issues. Full-scale testing has provided critical design verification of the ICV{sup TM} process before operating the Hanford pilot-plant. In 2007, the project's fifth full-scale test, called FS-38D, (also known as the Integrated Dryer Melter Test, or IDMT,) was performed. This test had three primary objectives: 1) Demonstrate the simultaneous and integrated operation of the ICV{sup TM} melter with a 10,000- liter dryer, 2) Demonstrate the effectiveness of a new feed reformulation and change in process methodology towards reducing the production and migration of molten ionic salts (MIS), and, 3) Demonstrate that an acceptable glass product is produced under these conditions. Testing was performed from August 8 to 17, 2007. Process and analytical results demonstrated that the primary test objectives, along with a dozen supporting objectives, were successfully met. Glass performance exceeded all disposal performance criteria. A previous issue with MIS containment was successfully resolved in FS-38D, and the ICV{sup TM} melter was integrated with a full-scale, 10,000-liter dryer. This paper describes the rationale for performing the test, the purpose and outcome of scale-up tests preceding it, and the performance and outcome of FS-38D. (authors)« less

Missed opportunities to offer HIV tests to high-risk groups during general practitioners’ STI-related consultations: an observational study

PubMed Central

Joore, I K; Reukers, D F M; Donker, G A; van Sighem, A I; Op de Coul, E L M; Prins, J M; Geerlings, S E; Barth, R E; van Bergen, J E A M; van den Broek, I V

2016-01-01

Objectives Prior research has shown that Dutch general practitioners (GPs) do not always offer HIV testing and the number of undiagnosed HIV patients remains high. We aimed to further investigate the frequency and reasons for (not) testing for HIV and the contribution of GPs to the diagnosis of HIV infections in the Netherlands. Design Observational study. Setting (1) Dutch primary care network of 42–45 sentinel practices where report forms during sexually transmitted infection (STI)-related consultations were routinely collected, 2008–2013. (2) Dutch observational cohort with medical data of HIV-positive patients in HIV care, 2008–2013. Outcome measures The proportion of STI-related consultations in patients from high-risk groups tested for HIV, with additional information requested from GPs on HIV testing preconsultation or postconsultation for whom HIV testing was indicated, but not performed. Next, information was collected on the profile of HIV-positive patients entering specialised HIV care following diagnosis by GPs. Results Initially, an HIV test was reported (360/907) in 40% of STI-related consultations in high-risk groups. Additionally, in 26% of consultations an HIV test had been performed in previous or follow-up consultations or at different STI-care facilities. The main reasons for not testing were perceived insignificant risk; ‘too’ recent risk according to GPs or the reluctance of patients. The initiative of the patient was a strong determinant for HIV testing. GPs diagnosed about one third of all newly found cases of HIV. Compared with STI clinics, HIV-positive patients diagnosed in general practice were more likely to be older, female, heterosexual male or sub-Saharan African. Conclusions In one-third of the STI-related consultations of persons from high-risk groups, no HIV test was performed in primary care, which is lower than previously reported. Risk-based testing has intrinsic limitations and implementation of new additional strategies in primary care is warranted. PMID:26801464

Development of Enhanced Avionics Flight Hardware Selection Process

NASA Technical Reports Server (NTRS)

Smith, K.; Watson, G. L.

2003-01-01

The primary objective of this research was to determine the processes and feasibility of using commercial off-the-shelf PC104 hardware for flight applications. This would lead to a faster, better, and cheaper approach to low-budget programs as opposed to the design, procurement. and fabrication of space flight hardware. This effort will provide experimental evaluation with results of flight environmental testing. Also, a method and/or suggestion used to bring test hardware up to flight standards will be given. Several microgravity programs, such as the Equiaxed Dendritic Solidification Experiment, Self-Diffusion in Liquid Elements, and various other programs, are interested in PC104 environmental testing to establish the limits of this technology.

An explorative study of school performance and antipsychotic medication.

PubMed

van der Schans, J; Vardar, S; Çiçek, R; Bos, H J; Hoekstra, P J; de Vries, T W; Hak, E

2016-09-21

Antipsychotic therapy can reduce severe symptoms of psychiatric disorders, however, data on school performance among children on such treatment are lacking. The objective was to explore school performance among children using antipsychotic drugs at the end of primary education. A cross-sectional study was conducted using the University Groningen pharmacy database linked to academic achievement scores at the end of primary school (Dutch Cito-test) obtained from Statistics Netherlands. Mean Cito-test scores and standard deviations were obtained for children on antipsychotic therapy and reference children, and statistically compared using analyses of covariance. In addition, differences in subgroups as boys versus girls, ethnicity, household income, and late starters (start date within 12 months of the Cito-test) versus early starters (start date > 12 months before the Cito-test) were tested. In all, data from 7994 children could be linked to Cito-test scores. At the time of the Cito-test, 45 (0.6 %) were on treatment with antipsychotics. Children using antipsychotics scored on average 3.6 points lower than the reference peer group (534.5 ± 9.5). Scores were different across gender and levels of household income (p < 0.05). Scores of early starters were significantly higher than starters within 12 months (533.7 ± 1.7 vs. 524.1 ± 2.6). This first exploration showed that children on antipsychotic treatment have lower school performance compared to the reference peer group at the end of primary school. This was most noticeable for girls, but early starters were less affected than later starters. Due to the observational cross-sectional nature of this study, no causality can be inferred, but the results indicate that school performance should be closely monitored and causes of underperformance despite treatment warrants more research.

ORNL rod-bundle heat-transfer test data. Volume 2. Thermal-Hydraulic Test Facility experimental data report for test 3. 03. 6AR - transient film boiling in upflow

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mullins, C. B.; Felde, D. K.; Sutton, A. G.

1982-04-01

Reduced instrument responses are presented for Thermal-Hydraulic Test Facility (THTF) Test 3.03.6AR. This test was conducted by members of the ORNL Pressurized-Water-Reactor (PWR) Blowdown Heat Transfer (BDHT) Separate-Effects Program on May 21, 1980. Objective was to investigate heat transfer phenomena believed to occur in PWRs during accidents, including small and large break loss-of-coolant accidents. Test 3.03.6AR was conducted to obtain transient film boiling data in rod bundle geometry under reactor accident-type conditions. The primary purpose of this report is to make the reduced instrument responses for THTF Test 3.03.6AR available. Included in the report are uncertainties in the instrument responses,more » calculated mass flows, and calculated rod powers.« less

Step 1: C3 Flight Demo Data Analysis Plan

NASA Technical Reports Server (NTRS)

2005-01-01

The Data Analysis Plan (DAP) describes the data analysis that the C3 Work Package (WP) will perform in support of the Access 5 Step 1 C3 flight demonstration objectives as well as the processes that will be used by the Flight IPT to gather and distribute the data collected to satisfy those objectives. In addition to C3 requirements, this document will encompass some Human Systems Interface (HSI) requirements in performing the C3 flight demonstrations. The C3 DAP will be used as the primary interface requirements document between the C3 Work Package and Flight Test organizations (Flight IPT and Non-Access 5 Flight Programs). In addition to providing data requirements for Access 5 flight test (piggyback technology demonstration flights, dedicated C3 technology demonstration flights, and Airspace Operations Demonstration flights), the C3 DAP will be used to request flight data from Non- Access 5 flight programs for C3 related data products

Wind Tunnel Test Results of Fairings on A.004 Scale Model Rockwell Space Shuttle Integrated Vehicle Aerodynamic Characteristics at Mach Numbers from 0.6 to 4.96 (IA62F)

NASA Technical Reports Server (NTRS)

Allen, E. C.; Hamilton, T.

1974-01-01

Experimental aerodynamic investigations were conducted on a .004 scale model (34-OTS) orbiter, external tank, and solid rocket booster combined as an integrated vehicle in the NASA/MSFC 14 x 14 inch trisonic wind tunnel. The primary test objective was to determine the effect of a full length orbiter/external tank fairing on axial force. Secondary objectives were to define the static stability characteristics of the mated vehicle configuration with fairings over a Mach number range of 0.6 thru 4.96. Six component aerodynamic force and moment data were recorded over an angle of attack range from -10 deg to 10 deg at 0 deg sideslip angle and from -10 deg to 10 deg sideslip range at 0 deg and 5 deg angle of attack. Plotted and tabular results are presented herein.

Primary teachers' subject matter knowledge: decimals

NASA Astrophysics Data System (ADS)

Ubuz, Behiye; Yayan, Betül

2010-09-01

The main objective of this study was to investigate primary teachers' subject matter knowledge in the domain of decimals and more elaborately to investigate their performance and difficulties in reading scale, ordering numbers, finding the nearest decimal and doing operations, such as addition and subtraction. The difficulties in these particular areas are analysed and suggestions are made regarding their causes. Further, factors that influence this knowledge were explored. The sample of the study was 63 primary teachers. A decimal concepts test including 18 tasks was administered and the total scores for the 63 primary teachers ranged from 3 to 18 with a mean and median of 12. Fifty per cent of the teachers were above the mean score. The detailed investigation of the responses revealed that the primary teachers faced similar difficulties that students and pre-service teachers faced. Discrepancy on teachers' knowledge revealed important differences based on educational level attained, but not the number of years of teaching experience and experience in teaching decimals. Some suggestions have been made regarding the implications for pre- and in-service teacher training.

Hover test of a full-scale hingeless helicopter rotor: Aeroelastic stability, performance and loads data. [wind tunnel tests

NASA Technical Reports Server (NTRS)

Peterson, R. L.; Warmbrodt, W.

1984-01-01

A hover test of a full-scale, hingeless rotor system was conducted in the NASA Ames 40- by 80-foot wind tunnel. The rotor was tested on the Ames rotor test apparatus. Rotor aeroelastic stability, performance, and loads at various rotational speeds and thrust coefficients were investigated. The primary objective was to determine the inplane stability characteristics of the rotor system. Rotor inplane damping data were obtained for operation between 350 and 425 rpm (design speed), and for thurst coefficients between 0.0 and 0.12. The rotor was stable for all conditions tested. At constant rotor rotational speed, a minimum inplane dampling level was obtained at a thrust coefficient approximately = 0.02. At constant rotor lift, a minimum in rotor inplane damping was measured at 400 rpm.

Is an opportunistic primary care-based intervention for non-responders to bowel screening feasible and acceptable? A mixed-methods feasibility study in Scotland

PubMed Central

Calanzani, Natalia; Cavers, Debbie; Vojt, Gabriele; Orbell, Sheina; Steele, Robert J C; Brownlee, Linda; Smith, Steve; Patnick, Julietta; Weller, David; Campbell, Christine

2017-01-01

Objectives We aimed to test whether a brief, opportunistic intervention in general practice was a feasible and acceptable way to engage with bowel screening non-responders. Design This was a feasibility study testing an intervention which comprised a brief conversation during routine consultation, provision of a patient leaflet and instructions to request a replacement faecal occult blood test kit. A mixed-methods approach to evaluation was adopted. Data were collected from proformas completed after each intervention, from the Bowel Screening Centre database and from questionnaires. Semi-structured interviews were carried out. We used descriptive statistics, content and framework analysis to determine intervention feasibility and acceptability. Participants Bowel screening non-responders (as defined by the Scottish Bowel Screening Centre) and primary care professionals working in five general practices in Lothian, Scotland. Primary and secondary outcome measures Several predefined feasibility parameters were assessed, including numbers of patients engaging in conversation, requesting a replacement kit and returning it, and willingness of primary care professionals to deliver the intervention. Results The intervention was offered to 258 patients in five general practices: 220 (87.0%) engaged with the intervention, 60 (23.3%) requested a new kit, 22 (8.5%) kits were completed and returned. Interviews and questionnaires suggest that the intervention was feasible, acceptable and consistent with an existing health prevention agenda. Reported challenges referred to work-related pressures, time constraints and practice priorities. Conclusions This intervention was acceptable and resulted in a modest increase in non-responders participating in bowel screening, although outlined challenges may affect sustained implementation. The strategy is also aligned with the increasing role of primary care in promoting bowel screening. PMID:29025829

Primary goals, information-giving and men’s understanding: a qualitative study of Australian and UK doctors’ varied communication about PSA screening

PubMed Central

Pickles, Kristen; Rychetnik, Lucie; McCaffery, Kirsten; Entwistle, Vikki A

2018-01-01

Objectives (1) To characterise variation in general practitioners’ (GPs’) accounts of communicating with men about prostate cancer screening using the prostate-specific antigen (PSA) test, (2) to characterise GPs’ reasons for communicating as they do and (3) to explain why and under what conditions GP communication approaches vary. Study design and setting A grounded theory study. We interviewed 69 GPs consulting in primary care practices in Australia (n=40) and the UK (n=29). Results GPs explained their communication practices in relation to their primary goals. In Australia, three different communication goals were reported: to encourage asymptomatic men to either have a PSA test, or not test, or alternatively, to support men to make their own decision. As well as having different primary goals, GPs aimed to provide different information (from comprehensive to strongly filtered) and to support men to develop different kinds of understanding, from population-level to ‘gist’ understanding. Taking into account these three dimensions (goals, information, understanding) and building on Entwistle et al’s Consider an Offer framework, we derived four overarching approaches to communication: Be screened, Do not be screened, Analyse and choose, and As you wish. We also describe ways in which situational and relational factors influenced GPs’ preferred communication approach. Conclusion GPs’ reported approach to communicating about prostate cancer screening varies according to three dimensions—their primary goal, information provision preference and understanding sought—and in response to specific practice situations. If GP communication about PSA screening is to become more standardised in Australia, it is likely that each of these dimensions will require attention in policy and practice support interventions. PMID:29362252

Characteristics of an Outpatient Treatment Sample by Primary Substance of Abuse

PubMed Central

Campbell, Aimee N. C.; Nunes, Edward V.; McClure, Erin A.; Hu, Mei-Chen; Turrigiano, Eva; Goldman, Bruce; Stabile, Patricia Quinn

2013-01-01

Objective The current study examines sociodemographic and clinical characteristics, as a function of primary substance of abuse, among clients approached, screened, and assessed for eligibility in a 10-site effectiveness trial of a web-based psychosocial intervention for substance use disorders. Consistent with the design of effectiveness trials, eligibility criteria were broad and exclusion criteria minimal; thus, the recruited sample may be viewed as relatively representative of patients seeking treatment throughout the United States. Methods Chi-square tests for categorical variables and F-tests for continuous variables were used to analyze demographic, substance use, physical and mental health, and sexual risk data collected at screening and baseline; pairwise comparisons between primary substance subgroups for baseline data were conducted if the test statistic p-value was ≤ .01. Results Few participants expressed disinterest in the study at screening due to the computer-assisted intervention. A diverse sample of substance users completed baseline and were enrolled: 22.9% marijuana; 21.7% opiates; 20.9% alcohol; 20.5% cocaine; and 13.9% stimulants. Marijuana users demonstrated the greatest differences across primary substances: they were younger, less likely to be married or attend 12-step meetings, and more likely to be in treatment as a result of criminal justice involvement. All patients, even marijuana users, reported comparable rates of co-occurring mental health disorders and sexual risk, as well as substantial rates of polysubstance use disorders. Conclusion Primary substance of abuse may be a less important indicator of overall severity compared to co-occurring disorders and other factors common across treatment seekers, further demonstrating the need for integrated treatment services and care, as well as comprehensive pre-treatment assessment. PMID:24089040

A Predictive Algorithm to Detect Opioid Use Disorder

PubMed Central

Lee, Chee; Sharma, Maneesh; Kantorovich, Svetlana

2018-01-01

Purpose: The purpose of this study was to determine the clinical utility of an algorithm-based decision tool designed to assess risk associated with opioid use in the primary care setting. Methods: A prospective, longitudinal study was conducted to assess the utility of precision medicine testing in 1822 patients across 18 family medicine/primary care clinics in the United States. Using the profile, patients were categorized into low, moderate, and high risk for opioid use. Physicians who ordered testing were asked to complete patient evaluations and document their actions, decisions, and perceptions regarding the utility of the precision medicine tests. Results: Approximately 47% of primary care physicians surveyed used the profile to guide clinical decision-making. These physicians rated the benefit of the profile on patient care an average of 3.6 on a 5-point scale (1 indicating no benefit and 5 indicating significant benefit). Eighty-eight percent of all clinicians surveyed felt the test exhibited some benefit to their patient care. The most frequent utilization for the profile was to guide a change in opioid prescribed. Physicians reported greater benefit of profile utilization for minority patients. Patients whose treatment was guided by the profile had pain levels that were reduced, on average, 2.7 levels on the numeric rating scale. Conclusions: The profile provided primary care physicians with a useful tool to stratify the risk of opioid use disorder and was rated as beneficial for decision-making and patient improvement by the majority of physicians surveyed. Physicians reported the profile resulted in greater clinical improvement for minorities, highlighting the objective use of this profile to guide judicial use of opioids in high-risk patients. Significantly, when physicians used the profile to guide treatment decisions, patient-reported pain was greatly reduced. PMID:29383324

Computational Design Tool for the Synthesis and Optimization of Gel Formulations (SOGeF)

DTIC Science & Technology

2009-01-01

ACCOMPLISHMENTS 2.1 Phase I Technical Objectives TIle primary technical objective of the Phase I program was the development of a model(s) to describe the...Figure 37: Storage Modulus G’, Loss Modulus G", and Stress vs. Strain. Yield Stress ~460Pa. (Tri-ethylamine 11% Cabosil) The primary detenninant of...GUI The primary objective of this task was to design and implement a graphical user interface (GUI) for the NN algorithms and gel database files. The

Saturn Apollo Program

NASA Image and Video Library

1968-01-01

AS-204, the fourth Saturn IB launch vehicle, developed by the Marshall Space Flight Center (MSFC), awaits its January 22, 1968 liftoff from Cape Canaveral, Florida for the unmarned Apollo 5 mission. Primary mission objectives included the verification of the Apollo Lunar Module's (LM) ascent and descent propulsion systems and an evaluation of the S-IVB stage instrument unit performance. In all, nine Saturn IB flights were made, ending with the Apollo-Soyuz Test Project in July 1975.

A chamber investigation of the IR and visible wavelength obscuration properties of pyrotechnically generated smokes

NASA Astrophysics Data System (ADS)

Hanley, J. T.; Mack, E. J.

1985-05-01

The overall objective of the program is the development of an effective screening agent to both visible and IR wavelengths utilizing pyrotechnically-generated hygroscopic aerosol. In pursuit of an effective IR wavelength screen and an increased understanding of the particle formation mechanisms and resultant size distribution, the primary objective of this year's effort was to evaluate the influence of an energetic binder (GAP) on the performance of two pyrotechnics, one which produced a KCL aerosol, the other a mixed aerosol, the other a mixed aerosol of MgCl2 and carbon. Comparison tests were run, in Calspan's 600 cu m test chamber, in which the performance of the energetic vs. non-energetic pyrotechnics was compared in terms of mass yield, payload mass extinction coefficient, aerosol decay rate and size distribution. A secondary objective of limited scope was to investigate the potential of using IR absorbing surface active agents to coat the smoke aerosol so as to enhance the smoke's IR wavelength absorption as well as inhibit subsequent aerosol evaporation upon exposure to decreasing humidity.

Uncued Low SNR Detection with Likelihood from Image Multi Bernoulli Filter

NASA Astrophysics Data System (ADS)

Murphy, T.; Holzinger, M.

2016-09-01

Both SSA and SDA necessitate uncued, partially informed detection and orbit determination efforts for small space objects which often produce only low strength electro-optical signatures. General frame to frame detection and tracking of objects includes methods such as moving target indicator, multiple hypothesis testing, direct track-before-detect methods, and random finite set based multiobject tracking. This paper will apply the multi-Bernoilli filter to low signal-to-noise ratio (SNR), uncued detection of space objects for space domain awareness applications. The primary novel innovation in this paper is a detailed analysis of the existing state-of-the-art likelihood functions and a likelihood function, based on a binary hypothesis, previously proposed by the authors. The algorithm is tested on electro-optical imagery obtained from a variety of sensors at Georgia Tech, including the GT-SORT 0.5m Raven-class telescope, and a twenty degree field of view high frame rate CMOS sensor. In particular, a data set of an extended pass of the Hitomi Astro-H satellite approximately 3 days after loss of communication and potential break up is examined.

Follow on Research for Multi-Utility Technology Test Bed Aircraft at NASA Dryden Flight Research Center (FY13 Progress Report)

NASA Technical Reports Server (NTRS)

Pak, Chan-Gi

2013-01-01

Modern aircraft employ a significant fraction of their weight in composite materials to reduce weight and improve performance. Aircraft aeroservoelastic models are typically characterized by significant levels of model parameter uncertainty due to the composite manufacturing process. Small modeling errors in the finite element model will eventually induce errors in the structural flexibility and mass, thus propagating into unpredictable errors in the unsteady aerodynamics and the control law design. One of the primary objectives of Multi Utility Technology Test-bed (MUTT) aircraft is the flight demonstration of active flutter suppression, and therefore in this study, the identification of the primary and secondary modes for the structural model tuning based on the flutter analysis of MUTT aircraft. The ground vibration test-validated structural dynamic finite element model of the MUTT aircraft is created in this study. The structural dynamic finite element model of MUTT aircraft is improved using the in-house Multi-disciplinary Design, Analysis, and Optimization tool. In this study, two different weight configurations of MUTT aircraft have been improved simultaneously in a single model tuning procedure.

Adherence of Low-income Women to Cancer Screening Recommendations

PubMed Central

O'Malley, Ann S; Forrest, Christopher B; Mandelblatt, Jeanne

2002-01-01

BACKGROUND African-American and low-income women have lower rates of cancer screening and higher rates of late-stage disease than do their counterparts. OBJECTIVE To examine the effects of primary care, health insurance, and HMO participation on adherence to regular breast, cervical, and colorectal cancer screening. DESIGN Random-digit-dial and targeted household telephone survey of a population-based sample. SETTING Washington, D.C. census tracts with ≥30% of households below 200% of federal poverty threshold. PARTICIPANTS Included in the survey were 1,205 women over age 40, 82% of whom were African American. MAIN OUTCOME MEASURES Adherence was defined as reported receipt of the last 2 screening tests within recommended intervals for age. RESULTS The survey completion rate was 85%. Overall, 75% of respondents were adherent to regular Pap smears, 66% to clinical breast exams, 65% to mammography, and 29% to fecal occult blood test recommendations. Continuity with a single primary care practitioner, comprehensive service delivery, and higher patient satisfaction with the relationships with primary care practitioners were associated with higher adherence across the 4 screening tests, after considering other factors. Coordination of care also was associated with screening adherence for women age 65 and over, but not for the younger women. Compared with counterparts in non-HMO plans, women enrolled in health maintenance organizations were also more likely to be adherent to regular screening (e.g., Pap, odds ratio [OR] 1.89, 95% confidence interval [CI] 1.11 to 3.17; clinical breast exam, OR 2.04, 95% CI 1.21 to 3.44; mammogram, OR 1.95, 95% CI 1.15 to 3.31; fecal occult blood test, OR 1.70, 95% CI 1.01 to 2.83.) CONCLUSIONS Organizing healthcare services to promote continuity with a specific primary care clinician, a comprehensive array of services available at the primary care delivery site, coordination among providers, and better patient-practitioner relationships are likely to improve inner-city, low-income women's adherence to cancer screening recommendations. PMID:11841530

Testing of an advanced thermochemical conversion reactor system

NASA Astrophysics Data System (ADS)

1990-01-01

This report presents the results of work conducted by MTCI to verify and confirm experimentally the ability of the MTCI gasification process to effectively generate a high-quality, medium-Btu gas from a wider variety of feedstock and waste than that attainable in air-blown, direct gasification systems. The system's overall simplicity, due to the compact nature of the pulse combustor, and the high heat transfer rates attainable within the pulsating flow resonance tubes, provide a decided and near-term potential economic advantage for the MTCI indirect gasification system. The primary objective was the design, construction, and testing of a Process Design Verification System for an indirectly heated, thermochemical fluid-bed reactor and a pulse combustor an an integrated system that can process alternative renewable sources of energy such as biomass, black liquor, municipal solid waste and waste hydrocarbons, including heavy oils into a useful product gas. The test objectives for the biomass portion of this program were to establish definitive performance data on biomass feedstocks covering a wide range of feedstock qualities and characteristics. The test objectives for the black liquor portion of this program were to verify the operation of the indirect gasifier on commercial black liquor containing 65 percent solids at several temperature levels and to characterize the bed carbon content, bed solids particle size and sulfur distribution as a function of gasification conditions.

Determining the Primary Endpoint for a Stimulant Abuse Trial: Lessons Learned from STRIDE (CTN 0037)

PubMed Central

Trivedi, Madhukar H.; Greer, Tracy L.; Potter, Jennifer Sharpe; Grannemann, Bruce D.; Nunes, Edward V.; Rethorst, Chad; Warden, Diane; Ring, Kolette M.; Somoza, Eugene

2012-01-01

Background No consensus is available for identifying the best primary outcome for substance abuse trials. While abstinence is the most desirable outcome for substance use interventions, a wide variety of other endpoints have been used to evaluate efficacy trials. Objectives This report provides a framework for determining an optimal primary endpoint and the relevant measurement approach for substance use disorder treatment trials. The framework was developed based on a trial for stimulant abuse using exercise as an augmentation treatment, delivered within the NIDA Clinical Trials Network. The use of a common primary endpoint across trials will facilitate comparisons of treatment efficacy. Methods Primary endpoint options in existing substance abuse studies were evaluated. This evaluation included surveys of the literature for endpoints and measurement approaches, followed by assessment of endpoint choices against study design issues, population characteristics, tests of sensitivity and tests of clinical meaningfulness. Conclusion We concluded that the best current choice for a primary endpoint is percent days abstinent, as measured by the Time Line Follow Back (TLFB) interview conducted three times a week with recall aided by a take-home Substance Use Diary. To further improve the accuracy of the self-reported drug use, an algorithm will be applied to reconcile the results from the TLFB with the results of qualitative urine drug screens. Scientific Significance There is a need for a standardized endpoint in this field to allow for comparison across treatment studies, and we suggest that the recommended endpoint be considered for use in this field. PMID:21854276

Objective Structured Assessment of Technical Skills (OSATS) evaluation of theoretical versus hands-on training of vaginal breech delivery management: a randomized trial.

PubMed

Buerkle, Bernd; Rueter, Katharina; Hefler, Lukas A; Tempfer-Bentz, Eva-Katrin; Tempfer, Clemens B

2013-12-01

To compare the skills of performing a vaginal breech (VB) delivery after hands-on training versus demonstration. We randomized medical students to a 30-min demonstration (group 1) or a 30-min hands-on (group 2) training session using a standardized VB management algorithm on a pelvic training model. Subjects were tested with a 25 item Objective Structured Assessment of Technical Skills (OSATS) scoring system immediately after training and 72 h thereafter. OSATS scores were the primary outcome. Performance time (PT), self assessment (SA), confidence (CON), and global rating scale (GRS) were the secondary outcomes. Statistics were performed using the Mann-Whitney U-test, chi-square test, and multiple linear regression analysis. 172 subjects were randomized. OSATS scores (primary outcome) were significantly higher in group 2 (n=88) compared to group 1 (n=84) (21.18±2.29 vs. 20.19±2.37, respectively; p=0.006). The secondary outcomes GRS (10.31±2.28 vs. 9.17±2.21; p=0.001), PT (214.60±57.97 s vs. 246.98±59.34 s; p<0.0001), and CON (3.14±0.89 vs. 2.85±0.90; p=0.04) were also significantly different between groups, favoring group 2. After 72 h, primary and secondary outcomes were not significantly different between groups. In a multiple linear regression analysis, group assignment (odds ratio [OR] 1.60; 95% confidence interval [CI] 1.14-2.05; p<0.0001) and gender (OR 2.91; 95% CI 2.45-3.38; p<0.0001) independently influenced OSATS scores. Hands-on training leads to a significant improvement of VB management in a pelvic training model, but this effect was only seen in the short term. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Lunar-Mars Life Support Test Project. Phase 2; Human Factors and Crew Interactions

NASA Technical Reports Server (NTRS)

Ming, D. W.; Hurlbert, K. M.; Kirby, G.; Lewis, J. F.; ORear, P.

1997-01-01

Phase 2 of the Lunar-Mars Life Support Test Project was conducted in June and July of 1996 at the NASA Johnson Space Center. The primary objective of Phase 2 was to demonstrate and evaluate an integrated physicochemical air revitalization and regenerative water recovery system capable of sustaining a human crew of four for 30 days inside a closed chamber. The crew (3 males and 1 female) was continuously present inside a chamber throughout the 30-day test. The objective of this paper was to describe crew interactions and human factors for the test. Crew preparations for the test included training and familiarization of chamber systems and accommodations, and medical and psychological evaluations. During the test, crew members provided metabolic loads for the life support systems, performed maintenance on chamber systems, and evaluated human factors inside the chamber. Overall, the four crew members found the chamber to be comfortable for the 30-day test. The crew performed well together and this was attributed in part to team dynamics, skill mix (one commander, two system experts, and one logistics lead), and a complementary mix of personalities. Communication with and support by family, friends, and colleagues were identified as important contributors to the high morale of the crew during the test. Lessons learned and recommendations for future testing are presented by the crew in this paper.

Curriculum Guide for Teachers of Educable Mentally Retarded -- Primary.

ERIC Educational Resources Information Center

Palm Beach County Board of Public Instruction, West Palm Beach, FL.

Designed for use with primary level educable mentally handicapped children, the guide lists general objectives, gives a unit and a daily lesson plan on wise buying from the grocery or stationery store, and explains how to make experience charts. Over three-fourths of the guide consists of behavioral objectives with general objectives and terminal…

Association between Sick Leave Prescribing Practices and Physician Burnout and Empathy

PubMed Central

2015-01-01

Objectives To investigate the association between sick leave prescription and physician burnout and empathy in a primary care health district in Lleida, Spain. Methods This descriptive study included 108 primary care doctors from 22 primary care centers in Lleida in 2014 (183,600 patients). Burnout was measured with the Maslach Burnout Inventory and empathy with the Jefferson Scale of Physician Empathy. The reliability of the instruments was measured by calculating Cronbach’s alpha and normal distribution was analyzed using the Kolmogorov-Smirnov-Lilliefors and χ2 tests. Burnout and empathy scores were analyzed by age, sex, and place of work (urban vs rural). Sick leave data were obtained from the Catalan Health Institute. Results High empathy was significantly associated with low burnout. Neither empathy nor burnout were significantly associated with sick leave prescription. Conclusion Sick leave prescription by physicians is not associated with physicians' empathy or burnout and may mostly depend on prescribing guidelines. PMID:26196687

Cosmogenic-nuclide production by primary cosmic-ray protons

NASA Technical Reports Server (NTRS)

Reedy, R. C.

1985-01-01

The production rates of cosmogenic nuclides were calculated for the primary protons in the galactic and solar cosmic rays. At 1 AU, the long-term average fluxes of solar protons usually produce many more atoms of cosmogenic nuclide than the primary protons in the galactic cosmic rays (GCR). Because the particle fluxes inside meteorites and other large objects in space include many secondary neutrons, the production rates and ratios inside large objects are often very different from those by just the primary GCR protons. It is possible to determine if a small object, was small in space or broken from a meteorite. Because heliospherical modulation and other interactions change the GCR particle spectrum, the production of cosmogenic nuclides by the GCR particles outside the heliosphere will be different from that by modulated GCR primaries.

Evaluating the reliability of an injury prevention screening tool: Test-retest study.

PubMed

Gittelman, Michael A; Kincaid, Madeline; Denny, Sarah; Wervey Arnold, Melissa; FitzGerald, Michael; Carle, Adam C; Mara, Constance A

2016-10-01

A standardized injury prevention (IP) screening tool can identify family risks and allow pediatricians to address behaviors. To assess behavior changes on later screens, the tool must be reliable for an individual and ideally between household members. Little research has examined the reliability of safety screening tool questions. This study utilized test-retest reliability of parent responses on an existing IP questionnaire and also compared responses between household parents. Investigators recruited parents of children 0 to 1 year of age during admission to a tertiary care children's hospital. When both parents were present, one was chosen as the "primary" respondent. Primary respondents completed the 30-question IP screening tool after consent, and they were re-screened approximately 4 hours later to test individual reliability. The "second" parent, when present, only completed the tool once. All participants received a 10-dollar gift card. Cohen's Kappa was used to estimate test-retest reliability and inter-rater agreement. Standard test-retest criteria consider Kappa values: 0.0 to 0.40 poor to fair, 0.41 to 0.60 moderate, 0.61 to 0.80 substantial, and 0.81 to 1.00 as almost perfect reliability. One hundred five families participated, with five lost to follow-up. Thirty-two (30.5%) parent dyads completed the tool. Primary respondents were generally mothers (88%) and Caucasian (72%). Test-retest of the primary respondents showed their responses to be almost perfect; average 0.82 (SD = 0.13, range 0.49-1.00). Seventeen questions had almost perfect test-retest reliability and 11 had substantial reliability. However, inter-rater agreement between household members for 12 objective questions showed little agreement between responses; inter-rater agreement averaged 0.35 (SD = 0.34, range -0.19-1.00). One question had almost perfect inter-rater agreement and two had substantial inter-rater agreement. The IP screening tool used by a single individual had excellent test-retest reliability for nearly all questions. However, when a reporter changes from pre- to postintervention, differences may reflect poor reliability or different subjective experiences rather than true change.

Population screening for coeliac disease in primary care by district nurses using a rapid antibody test: diagnostic accuracy and feasibility study

PubMed Central

2007-01-01

Objective To evaluate the feasibility and diagnostic accuracy of screening for coeliac disease by rapid detection of IgA antibodies to tissue transglutaminase performed in primary care. Design District nurses screened 6 year old children using rapid antibody testing of finger prick blood. They also collected capillary blood samples for laboratory determination of IgA and IgG antibodies to endomysium and IgA antibodies to tissue transglutaminase. Children with positive rapid test results were directly sent for biopsy of the small intestine. Setting Primary care in Jász-Nagykun-Szolnok county, Hungary. Participants 2690 children (77% of 6 year olds living in the county) and 120 nurses. Main outcome measures Positivity for antibodies to endomysium or transglutaminase in the laboratory and coeliac disease confirmed at biopsy. Results 37 children (1.4%, 95% confidence interval 0.9% to 1.8%) had biopsy confirmed coeliac disease. Only five of these children had been diagnosed clinically before screening. Rapid testing had a 78.1% sensitivity (70.0% to 89.3%) and 100% specificity (88.4% to 100%) for a final diagnosis of coeliac disease by biopsy. Sensitivity was 65.1% (50.2% to 77.6%) and specificity was 100% (99.8% to 100%) compared with combined results of IgA and IgG laboratory tests. Trained laboratory workers detected 30 of the 31 newly diagnosed IgA competent patients with the rapid test kit used blindly. Median time to biopsy after a positive rapid test result was significantly shorter (20 days, range 4-148) than after a positive laboratory result (142 days, 70-256; P<0.001). Children with coeliac disease detected at screening were smaller and had worse health status than their peers but they improved on a gluten-free diet. Conclusions A simple rapid antibody test enabled primary care nurses to detect patients with coeliac disease in the community who were not picked up in clinical care. Extra training is needed to improve sensitivity. PMID:18063612

Improving Care for Patients With or at Risk for Chronic Kidney Disease Using Electronic Medical Record Interventions: A Pragmatic Cluster-Randomized Trial Protocol

PubMed Central

Nash, Danielle M.; Ivers, Noah M.; Young, Jacqueline; Jaakkimainen, R. Liisa; Garg, Amit X.; Tu, Karen

2017-01-01

Background: Many patients with or at risk for chronic kidney disease (CKD) in the primary care setting are not receiving recommended care. Objective: The objective of this study is to determine whether a multifaceted, low-cost intervention compared with usual care improves the care of patients with or at risk for CKD in the primary care setting. Design: A pragmatic cluster-randomized trial, with an embedded qualitative process evaluation, will be conducted. Setting: The study population comes from the Electronic Medical Record Administrative data Linked Database®, which includes clinical data for more than 140 000 rostered adults cared for by 194 family physicians in 34 clinics across Ontario, Canada. The 34 primary care clinics will be randomized to the intervention or control group. Intervention: The intervention group will receive resources from the “CKD toolkit” to help improve care including practice audit and feedback, printed educational materials for physicians and patients, electronic decision support and reminders, and implementation support. Measurements: Patients with or at risk for CKD within participating clinics will be identified using laboratory data in the electronic medical records. Outcomes will be assessed after dissemination of the CKD tools and after 2 rounds of feedback on performance on quality indicators have been sent to the physicians using information from the electronic medical records. The primary outcome is the proportion of patients aged 50 to 80 years with nondialysis-dependent CKD who are on a statin. Secondary outcomes include process of care measures such as screening tests, CKD recognition, monitoring tests, angiotensin-converting enzyme inhibitor or angiotensin receptor blocker prescriptions, blood pressure targets met, and nephrologist referral. Hierarchical analytic modeling will be performed to account for clustering. Semistructured interviews will be conducted with a random purposeful sample of physicians in the intervention group to understand why the intervention achieved the observed effects. Conclusions: If our intervention improves care, then the CKD toolkit can be adapted and scaled for use in other primary care clinics which use electronic medical records. Trial Registration: ClinicalTrials.gov Identifier: NCT02274298 PMID:28607686

Hierarchical Robot Control System and Method for Controlling Select Degrees of Freedom of an Object Using Multiple Manipulators

NASA Technical Reports Server (NTRS)

Platt, Robert (Inventor); Wampler, II, Charles W. (Inventor); Abdallah, Muhammad E. (Inventor)

2013-01-01

A robotic system includes a robot having manipulators for grasping an object using one of a plurality of grasp types during a primary task, and a controller. The controller controls the manipulators during the primary task using a multiple-task control hierarchy, and automatically parameterizes the internal forces of the system for each grasp type in response to an input signal. The primary task is defined at an object-level of control, e.g., using a closed-chain transformation, such that only select degrees of freedom are commanded for the object. A control system for the robotic system has a host machine and algorithm for controlling the manipulators using the above hierarchy. A method for controlling the system includes receiving and processing the input signal using the host machine, including defining the primary task at the object-level of control, e.g., using a closed-chain definition, and parameterizing the internal forces for each of grasp type.

Wind tunnel test IA300 analysis and results, volume 1

NASA Technical Reports Server (NTRS)

Kelley, P. B.; Beaufait, W. B.; Kitchens, L. L.; Pace, J. P.

1987-01-01

The analysis and interpretation of wind tunnel pressure data from the Space Shuttle wind tunnel test IA300 are presented. The primary objective of the test was to determine the effects of the Space Shuttle Main Engine (SSME) and the Solid Rocket Booster (SRB) plumes on the integrated vehicle forebody pressure distributions, the elevon hinge moments, and wing loads. The results of this test will be combined with flight test results to form a new data base to be employed in the IVBC-3 airloads analysis. A secondary objective was to obtain solid plume data for correlation with the results of gaseous plume tests. Data from the power level portion was used in conjunction with flight base pressures to evaluate nominal power levels to be used during the investigation of changes in model attitude, eleveon deflection, and nozzle gimbal angle. The plume induced aerodynamic loads were developed for the Space Shuttle bases and forebody areas. A computer code was developed to integrate the pressure data. Using simplified geometrical models of the Space Shuttle elements and components, the pressure data were integrated to develop plume induced force and moments coefficients that can be combined with a power-off data base to develop a power-on data base.

In-Flight Boundary-Layer Transition of a Large Flat Plate at Supersonic Speeds

NASA Technical Reports Server (NTRS)

Banks, D. W.; Frederick, M. A.; Tracy, R. R.; Matisheck, J. R.; Vanecek, N. D.

2012-01-01

A flight experiment was conducted to investigate the pressure distribution, local-flow conditions, and boundary-layer transition characteristics on a large flat plate in flight at supersonic speeds up to Mach 2.00. The tests used a NASA testbed aircraft with a bottom centerline mounted test fixture. The primary objective of the test was to characterize the local flow field in preparation for future tests of a high Reynolds number natural laminar flow test article. A second objective was to determine the boundary-layer transition characteristics on the flat plate and the effectiveness of using a simplified surface coating. Boundary-layer transition was captured in both analog and digital formats using an onboard infrared imaging system. Surface pressures were measured on the surface of the flat plate. Flow field measurements near the leading edge of the test fixture revealed the local flow characteristics including downwash, sidewash, and local Mach number. Results also indicated that the simplified surface coating did not provide sufficient insulation from the metallic structure, which likely had a substantial effect on boundary-layer transition compared with that of an adiabatic surface. Cold wall conditions were predominant during the acceleration to maximum Mach number, and warm wall conditions were evident during the subsequent deceleration.

An interstellar precursor mission

NASA Technical Reports Server (NTRS)

Jaffe, L. D.; Ivie, C.; Lewis, J. C.; Lipes, R. G.; Norton, H. N.; Stearns, J. W.; Stimpson, L.; Weissman, P.

1977-01-01

A mission out of the planetary system, with launch about the year 2000, could provide valuable scientific data as well as test some of the technology for a later mission to another star. Primary scientific objectives for the precursor mission concern characteristics of the heliopause, the interstellar medium, stellar distances (by parallax measurements), low energy cosmic rays, interplanetary gas distribution, and mass of the solar system. Secondary objectives include investigation of Pluto. Candidate science instruments are suggested. Individual spacecraft systems for the mission were considered, technology requirements and problem areas noted, and a number of recommendations made for technology study and advanced development. The most critical technology needs include attainment of 50-yr spacecraft lifetime and development of a long-life NEP system.

Urine drug testing results and paired oral fluid comparison from patients enrolled in long-term medication-assisted treatment in Tennessee.

PubMed

Miller, Katie L; Puet, Brandi L; Roberts, Ali; Hild, Cheryl; Carter, Jason; Black, David L

2017-05-01

Urine drug testing is recommended for individuals receiving medication-assisted treatment. It provides objective information for practitioners to consider and may serve as a protective factor against drug-related mortality. The primary objective of our study was to describe urine drug testing results for patients undergoing long-term medication-assisted treatment (≥6months). The secondary objective was to provide further evidence to establish oral fluid as a reliable alternative to urine. All subjects (n=639) included in the study were enrolled in one of five treatment centers in the state of Tennessee, and all urine specimens were positive for either methadone or buprenorphine. Nicotine (87%), caffeine (70%), marijuana (15%), alcohol (14%) and gabapentin (10%) were the most prevalent substances identified through urine drug testing. The presence of non-maintenance opioids (prescription and/or heroin) may represent relapse; these drugs were present in 10% of specimens tested. Evidence of illicit drug use (cocaine, heroin, marijuana and/or methamphetamine) was detected in 19% specimens. For 126 of the 639 subjects included in the study, paired oral fluid and urine test results were compared for agreement. Of the total paired urine and oral fluid tests, approximately 7% were positive for a drug in both specimen types and 91% were negative in both, resulting in an overall agreement of 98%. The study demonstrates continued use of illicit and commercially available medications in a medication-assisted treatment population undergoing long-term treatment. The results affirm the reliability of oral fluid as an alternative specimen type for compliance testing in this population. Copyright © 2017 Elsevier Inc. All rights reserved.

Effects of Continuous Positive Airway Pressure on Neurocognitive Function in Obstructive Sleep Apnea Patients: The Apnea Positive Pressure Long-term Efficacy Study (APPLES)

PubMed Central

Kushida, Clete A.; Nichols, Deborah A.; Holmes, Tyson H.; Quan, Stuart F.; Walsh, James K.; Gottlieb, Daniel J.; Simon, Richard D.; Guilleminault, Christian; White, David P.; Goodwin, James L.; Schweitzer, Paula K.; Leary, Eileen B.; Hyde, Pamela R.; Hirshkowitz, Max; Green, Sylvan; McEvoy, Linda K.; Chan, Cynthia; Gevins, Alan; Kay, Gary G.; Bloch, Daniel A.; Crabtree, Tami; Dement, William C.

2012-01-01

Study Objective: To determine the neurocognitive effects of continuous positive airway pressure (CPAP) therapy on patients with obstructive sleep apnea (OSA). Design, Setting, and Participants: The Apnea Positive Pressure Long-term Efficacy Study (APPLES) was a 6-month, randomized, double-blind, 2-arm, sham-controlled, multicenter trial conducted at 5 U.S. university, hospital, or private practices. Of 1,516 participants enrolled, 1,105 were randomized, and 1,098 participants diagnosed with OSA contributed to the analysis of the primary outcome measures. Intervention: Active or sham CPAP Measurements: Three neurocognitive variables, each representing a neurocognitive domain: Pathfinder Number Test-Total Time (attention and psychomotor function [A/P]), Buschke Selective Reminding Test-Sum Recall (learning and memory [L/M]), and Sustained Working Memory Test-Overall Mid-Day Score (executive and frontal-lobe function [E/F]) Results: The primary neurocognitive analyses showed a difference between groups for only the E/F variable at the 2 month CPAP visit, but no difference at the 6 month CPAP visit or for the A/P or L/M variables at either the 2 or 6 month visits. When stratified by measures of OSA severity (AHI or oxygen saturation parameters), the primary E/F variable and one secondary E/F neurocognitive variable revealed transient differences between study arms for those with the most severe OSA. Participants in the active CPAP group had a significantly greater ability to remain awake whether measured subjectively by the Epworth Sleepiness Scale or objectively by the maintenance of wakefulness test. Conclusions: CPAP treatment improved both subjectively and objectively measured sleepiness, especially in individuals with severe OSA (AHI > 30). CPAP use resulted in mild, transient improvement in the most sensitive measures of executive and frontal-lobe function for those with severe disease, which suggests the existence of a complex OSA-neurocognitive relationship. Clinical Trial Information: Registered at clinicaltrials.gov. Identifier: NCT00051363. Citation: Kushida CA; Nichols DA; Holmes TH; Quan SF; Walsh JK; Gottlieb DJ; Simon RD; Guilleminault C; White DP; Goodwin JL; Schweitzer PK; Leary EB; Hyde PR; Hirshkowitz M; Green S; McEvoy LK; Chan C; Gevins A; Kay GG; Bloch DA; Crabtree T; Demen WC. Effects of continuous positive airway pressure on neurocognitive function in obstructive sleep apnea patients: the Apnea Positive Pressure Long-term Efficacy Study (APPLES). SLEEP 2012;35(12):1593-1602. PMID:23204602

Development of stitching reinforcement for transport wing panels

NASA Technical Reports Server (NTRS)

Palmer, Raymond J.; Dow, Marvin B.; Smith, Donald L.

1991-01-01

The NASA Advanced Composites Technology (ACT) program has the objective of providing the technology required to obtain the full benefit of weight savings and performance improvements offered by composite primary aircraft structures. Achieving the objective is dependent upon developing composite materials and structures which are damage tolerant and economical to manufacture. Researchers are investigating stitching reinforcement combined with resin transfer molding to produce materials meeting the ACT program objective. Research is aimed at materials, processes, and structural concepts for application in both transport wings and fuselages, but the emphasis to date has been on wing panels. Empirical guidelines are being established for stitching reinforcement in structures designed for heavy loads. Results are presented from evaluation tests investigating stitching types, threads, and density (penetrations per square inch). Tension strength, compression strength, and compression after impact data are reported.

Presentation Annotated

NASA Technical Reports Server (NTRS)

Ditto, Thomas

2017-01-01

This Report is not the latest word on an old idea but the first word on a new one. The new idea reverses the old one, the axiom that the best primary objective for an astronomical telescope exhibits the least chromatic aberration. That axiomatic distinction goes back to a young Isaac Newton who knew from experiments with prisms and mirrors in the 1660's that magnification with a reflection primary was completely free of the dispersion he saw with refraction. The superiority of reflection primary objectives for eyeball or photographic viewing is now considered obvious. It was this piece of wisdom on achromatic primary objectives that led to the dominance of the parabolic mirror as the means to collect star light. Newton was aware of the problem when he introduced his telescope to the scientific world in 1670.This Report is not the latest word on an old idea but the first word on a new one. The new idea reverses the old one, the axiom that the best primary objective for an astronomical telescope exhibits the least chromatic aberration. That axiomatic distinction goes back to a young Isaac Newton who knew from experiments with prisms and mirrors in the 1660's that magnification with a reflection primary was completely free of the dispersion he saw with refraction. The superiority of reflection primary objectives for eyeball or photographic viewing is now considered obvious. Actually, Newton's design innovation was in a secondary mirror, a plane mirror far more easily fabricated than Gregory's embodiment of 1663 which required two curved mirrors.

Analytical performance, agreement and user-friendliness of six point-of-care testing urine analysers for urinary tract infection in general practice

PubMed Central

Schot, Marjolein J C; van Delft, Sanne; Kooijman-Buiting, Antoinette M J; de Wit, Niek J; Hopstaken, Rogier M

2015-01-01

Objective Various point-of-care testing (POCT) urine analysers are commercially available for routine urine analysis in general practice. The present study compares analytical performance, agreement and user-friendliness of six different POCT urine analysers for diagnosing urinary tract infection in general practice. Setting All testing procedures were performed at a diagnostic centre for primary care in the Netherlands. Urine samples were collected at four general practices. Primary and secondary outcome measures Analytical performance and agreement of the POCT analysers regarding nitrite, leucocytes and erythrocytes, with the laboratory reference standard, was the primary outcome measure, and analysed by calculating sensitivity, specificity, positive and negative predictive value, and Cohen's κ coefficient for agreement. Secondary outcome measures were the user-friendliness of the POCT analysers, in addition to other characteristics of the analysers. Results The following six POCT analysers were evaluated: Uryxxon Relax (Macherey Nagel), Urisys 1100 (Roche), Clinitek Status (Siemens), Aution 11 (Menarini), Aution Micro (Menarini) and Urilyzer (Analyticon). Analytical performance was good for all analysers. Compared with laboratory reference standards, overall agreement was good, but differed per parameter and per analyser. Concerning the nitrite test, the most important test for clinical practice, all but one showed perfect agreement with the laboratory standard. For leucocytes and erythrocytes specificity was high, but sensitivity was considerably lower. Agreement for leucocytes varied between good to very good, and for the erythrocyte test between fair and good. First-time users indicated that the analysers were easy to use. They expected higher productivity and accuracy when using these analysers in daily practice. Conclusions The overall performance and user-friendliness of all six commercially available POCT urine analysers was sufficient to justify routine use in suspected urinary tract infections in general practice. PMID:25986635

Comparison of Clinical Results, Second-Look Arthroscopic Findings, and MRI Findings Between the Transportal and Outside-In Techniques for Double-Bundle Anatomic Anterior Cruciate Ligament Reconstruction: A Prospective, Randomized Controlled Trial With a Minimum 2-Year Follow-up.

PubMed

Kim, Jae Gyoon; Kang, Seung Hoon; Kim, Jun Ho; Lim, Chae Ouk; Wang, Joon Ho

2018-03-01

Although image analysis has shown that the outside-in (OI) technique is associated with different femoral tunnel geometry than the transportal (TP) technique in anatomic anterior cruciate ligament (ACL) reconstruction, it is not known whether clinical results differ between the 2 techniques. To compare clinical results, second-look arthroscopic findings, and magnetic resonance imaging (MRI) findings between the TP and OI techniques in anatomic double-bundle (DB) ACL reconstruction. Randomized controlled trial; Level of evidence, 2. From November 2010 to March 2013, 128 patients were enrolled in this study and were randomly assigned to either the TP group (64 patients) or the OI group (64 patients), and DB ACL reconstructions were performed. At the minimum 2-year follow-up (34.9 ± 10.9 months), 111 patients (86.7%) were evaluated with multiple clinical scores and stability tests (KT-2000 arthrometer, Lachman test, and pivot-shift test). Ninety-three knees were evaluated for graft continuity, graft tension, and synovialization by use of second-look arthroscopy. Seventy-eight knees were evaluated on MRI for graft continuity, femoral graft tunnel healing, and graft signal/noise quotient (SNQ). The primary outcome was KT-2000 arthrometer results. Results were compared between the TP and OI groups. No significant differences were found between the 2 groups in terms of KT-2000 arthrometer results, which was the primary outcome, and other clinical results, with the exception of the postoperative functional test of International Knee Documentation Committee (IKDC) objective score. The ratio of grade A and B on the postoperative functional test of IKDC objective score was significantly larger for the OI group (51/58) than the TP group (36/53) ( P = .005). The second-look arthroscopic findings were not significantly different between the 2 groups in either bundle ( P > .05). In addition, MRI findings did not differ significantly between the 2 groups ( P > .05). With the exception of the functional test of IKDC objective score, we found that clinical results, second-look arthroscopic findings, and MRI findings did not differ significantly between the OI and TP techniques for anatomic ACL reconstruction, although femoral tunnel geometries differed significantly between the 2 techniques.

Alternatives to ozone depleting refrigerants in test equipment

NASA Technical Reports Server (NTRS)

Hall, Richard L.; Johnson, Madeleine R.

1995-01-01

This paper describes the initial results of a refrigerant retrofit project at the Aerospace Guidance and Metrology Center (AGMC) at Newark Air Force Base, Ohio. The objective is to convert selected types of test equipment to properly operate on hydrofluorocarbon (HFC) alternative refrigerants, having no ozone depleting potential, without compromising system reliability or durability. This paper discusses the primary technical issues and summarizes the test results for 17 different types of test equipment: ten environmental chambers, two ultralow temperature freezers, two coolant recirculators, one temperature control unit, one vapor degreaser, and one refrigerant recovery system. The postconversion performance test results have been very encouraging: system capacity and input power remained virtually unchanged. In some cases, the minimum operating temperature increased by a few degrees as a result of the conversion, but never beyond AGMC's functional requirements.

The aerodynamics of running socks: Reality or rhetoric?

PubMed

Ashford, Robert L; White, Peter; Indramohan, Vivek

2011-12-01

The primary objective of this study was to test the aerodynamic properties of a selection of running and general sports socks. Eleven pairs of socks were tested in a specially constructed rig which was inserted into a fully calibrated wind tunnel. Wind test speeds included 3, 4, 5, 6, 12 and 45m/s. There was no significant difference between any of the socks tested for their aerodynamic properties. The drag coefficients calculated for each sock varied proportionally with the Reynolds number. No particular sock was more aerodynamic than any of the socks tested. There is no evidence that a sock that is "aerodynamically designed" will help an athlete go faster. This may be more product rhetoric than reality, and further work is justified if such claims are being made. Copyright © 2011 Elsevier Ltd. All rights reserved.

Magellan attitude and articulation control subsystem closed loop testing

NASA Technical Reports Server (NTRS)

Olschansky, David G.

1987-01-01

In the spring of 1989, the Magellan spacecraft will embark on a two-year mission to map the surface of the planet Venus. Guiding it there will be the Attitude and Articulation Control Subsystem (AACS). To ensure reliable operations the AACS is being put through a rigorous test program at Martin Marietta Denver Aerospace. Before Magellan ever leaves the Space Shuttle bay from which it is to be launched, its components will have flown a simulated spaceflight in a ground-based lab. The primary objectives of the test program are to verify form, fit, and function of the AACS, particularly subsystem external interfaces and functional operation of the flight software. This paper discusses the Magellan Closed Loop Test Systems which makes realistic tests possible by simulating the dynamic and 'visual' flight environment for AACS components in the lab.

SERT II thrusters - Still ticking after eleven years

NASA Technical Reports Server (NTRS)

Kerslake, W. R.

1981-01-01

The Space Electric Rocket Test II (SERT II) spacecraft was launched in 1970 with a primary objective of demonstrating long-term operation of a space electric thruster system. An overview is presented of all the SERT II testing conducted during the time from 1970 to 1981. Thruster testing and interaction results are considered, taking into account ion beam thrusting, distant neutralization, and the plasma beam thrust. In a discussion of durability testing, attention is given to the main cathodes, the neutralizer cathodes, the main keeper insulator, the H.V. grid insulators, the neutralizer propellant tanks, and the main propellant tanks. The most important result of the study is related to the confidence gained that mercury bombardment ion thruster systems can be built and operated in space on a routine basis with the same lifetime and performance as measured in ground testing.

Spirometry in primary care: An analysis of spirometry test quality in a regional primary care asthma program

PubMed Central

Licskai, Christopher J; Sands, Todd W; Paolatto, Lisa; Nicoletti, Ivan; Ferrone, Madonna

2012-01-01

BACKGROUND: Primary care office spirometry can improve access to testing and concordance between clinical practice and asthma guidelines. Compliance with test quality standards is essential to implementation. OBJECTIVE: To evaluate the quality of spirometry performed onsite in a regional primary care asthma program (RAP) by health care professionals with limited training. METHODS: Asthma educators were trained to perform spirometry during two 2 h workshops and supervised during up to six patient encounters. Quality was analyzed using American Thoracic Society (ATS) 1994 and ATS/European Respiratory Society (ERS) 2003 (ATS/ERS) standards. These results were compared with two regional reference sites: a primary care group practice (Family Medical Centre [FMC], Windsor, Ontario) and a teaching hospital pulmonary function laboratory (London Health Sciences Centre [LHSC], London, Ontario). RESULTS: A total of 12,815 flow-volume loops (FVL) were evaluated: RAP – 1606 FVL in 472 patient sessions; reference sites – FMC 4013 FVL in 573 sessions; and LHSC – 7196 in 1151 sessions. RAP: There were three acceptable FVL in 392 of 472 (83%) sessions, two reproducible FVL according to ATS criteria in 428 of 469 (91%) sessions, and 395 of 469 (84%) according to ATS/ERS criteria. All quality criteria – minimum of three acceptable and two reproducible FVL according to ATS criteria in 361 of 472 (77%) sessions and according to ATS/ERS criteria in 337 of 472 (71%) sessions. RAP met ATS criteria more often than the FMC (388 of 573 [68%]); however, less often than LHSC (1050 of 1151 [91%]; P<0.001). CONCLUSIONS: Health care providers with limited training and experience operating within a simple quality program achieved ATS/ERS quality spirometry in the majority of sessions in a primary care setting. The quality performance approached pulmonary function laboratory standards. PMID:22891184

Casein Phosphopeptide-Amorphous Calcium Phosphate and Shear Bond Strength of Adhesives to Primary Teeth Enamel

PubMed Central

Farokh Gisovar, Elham; Hedayati, Nassim; Shadman, Niloofar; Shafiee, Leila

2015-01-01

Background: CPP-ACP (Phosphopeptide-Amorphous Calcium Phosphate) has an important role in caries prevention in pediatric patients. This study was done, because of the great use of CPP-ACP and the need for restoration for teeth treated with CPP-ACP as well as the importance of shear bond strength of adhesives in the success of restorations. Objectives: This study aimed to evaluate the effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) on shear bond strength of dental adhesives to enamel of primary teeth molars. Materials and Methods: This in vitro study was conducted on 180 extracted primary molars. They were randomly divided into 6 groups and each group was divided into 2 subgroups (treated with CPP-ACP and untreated). In subgroups with CPP-ACP, enamel was treated with CPP-ACP paste 1 h/d for 5 days. Types of adhesives that were evaluated in this study were Tetric N-Bond, AdheSE, AdheSE One F, single Bond 2, SE Bond, and Adper Prompt L-Pop. Shear bond strength was tested with a universal testing machine and mode of failure was evaluated under stereomicroscope. Data were analyzed by T test, 2-way analysis of variance (ANOVA), Tukey and Fisher exact test using SPSS18. P < 0.05 was considered as significance level. Results: Shear bond strengths of different adhesive systems to enamel of primary teeth treated and untreated with CPP-ACP showed no significant difference (P > 0.05). Mode of failure in all groups regardless of CPP-ACP administration was mainly adhesive type. Our results indicated that CPP-ACP did not affect shear bond strength of studied adhesives to primary teeth enamel. Conclusions: To have a successful and durable composite restoration, having a high strength bonding is essential. Considering the wide use of CPP-ACP in preventing tooth decay and the role of adhesive shear bond strength (SBS) in success of composite restoration, we conducted the present study to evaluate the effect of CPP-ACP on the SBS of adhesives to primary teeth enamel. PMID:25793113

Experimental Concepts for Testing Seismic Hazard Models

NASA Astrophysics Data System (ADS)

Marzocchi, W.; Jordan, T. H.

2015-12-01

Seismic hazard analysis is the primary interface through which useful information about earthquake rupture and wave propagation is delivered to society. To account for the randomness (aleatory variability) and limited knowledge (epistemic uncertainty) of these natural processes, seismologists must formulate and test hazard models using the concepts of probability. In this presentation, we will address the scientific objections that have been raised over the years against probabilistic seismic hazard analysis (PSHA). Owing to the paucity of observations, we must rely on expert opinion to quantify the epistemic uncertainties of PSHA models (e.g., in the weighting of individual models from logic-tree ensembles of plausible models). The main theoretical issue is a frequentist critique: subjectivity is immeasurable; ergo, PSHA models cannot be objectively tested against data; ergo, they are fundamentally unscientific. We have argued (PNAS, 111, 11973-11978) that the Bayesian subjectivity required for casting epistemic uncertainties can be bridged with the frequentist objectivity needed for pure significance testing through "experimental concepts." An experimental concept specifies collections of data, observed and not yet observed, that are judged to be exchangeable (i.e., with a joint distribution independent of the data ordering) when conditioned on a set of explanatory variables. We illustrate, through concrete examples, experimental concepts useful in the testing of PSHA models for ontological errors in the presence of aleatory variability and epistemic uncertainty. In particular, we describe experimental concepts that lead to exchangeable binary sequences that are statistically independent but not identically distributed, showing how the Bayesian concept of exchangeability generalizes the frequentist concept of experimental repeatability. We also address the issue of testing PSHA models using spatially correlated data.

Influence of Primary Care Use on Population Delivery of Colorectal Cancer Screening

PubMed Central

Fenton, Joshua J.; Reid, Robert J.; Baldwin, Laura-Mae; Elmore, Joann G.; Buist, Diana S.M.; Franks, Peter

2009-01-01

Objective Colorectal cancer (CRC) screening is commonly initiated during primary care visits. Thus, at the population level, limited primary care attendance may constitute a substantial barrier to CRC screening uptake. Within a defined population, we quantified the percent of CRC screening underuse that is potentially explained by low use of primary care visits. Methods Among 48,712 adults aged 50-78 years eligible for CRC screening within a Washington state health plan, we estimated the degree to which a lack of CRC screening in 2002-2003 (fecal occult blood testing, sigmoidoscopy, or colonoscopy) was attributable to low primary care use, expressed as the population attributable risk percent (PAR%) associated with 0 to 3 primary care visits during the two-year period. Results In analyses adjusted for age, comorbidity, non-primary care visit use, and prior preventive service use, low primary care use in 2002-2003 was strongly associated with a lack of CRC screening among both women and men. However, a majority of unscreened women and men had >=4 primary care visits. Thus, whether low primary care use was defined as 0, 0 to 1, 0 to 2, or 0 to 3 primary care visits, the PAR% associated with low primary care use was large in neither women (range: 3.0-6.8%) nor men (range: 5.6-11.5%). Conclusions Health plan outreach efforts to encourage primary care attendance would be unlikely to substantially increase population uptake of CRC screening. In similar settings, resources might be more fruitfully devoted to the optimization of screening delivery during primary care visits that patients already attend. PMID:19190140

Development of a Ground Test and Analysis Protocol for NASA's NextSTEP Phase 2 Habitation Concepts

NASA Technical Reports Server (NTRS)

Gernhardt, Michael L.; Beaton, Kara H.; Chappell, Steven P.; Bekdash, Omar S.; Abercromby, Andrew F. J.

2018-01-01

The NASA Next Space Technologies for Exploration Partnerships (NextSTEP) program is a public-private partnership model that seeks commercial development of deep space exploration capabilities to support human spaceflight missions around and beyond cislunar space. NASA first issued the Phase 1 NextSTEP Broad Agency Announcement to U.S. industries in 2014, which called for innovative cislunar habitation concepts that leveraged commercialization plans for low-Earth orbit. These habitats will be part of the Deep Space Gateway (DSG), the cislunar space station planned by NASA for construction in the 2020s. In 2016, Phase 2 of the NextSTEP program selected five commercial partners to develop ground prototypes. A team of NASA research engineers and subject matter experts (SMEs) have been tasked with developing the ground-test protocol that will serve as the primary means by which these Phase 2 prototypes will be evaluated. Since 2008, this core test team has successfully conducted multiple spaceflight analog mission evaluations utilizing a consistent set of operational tools, methods, and metrics to enable the iterative development, testing, analysis, and validation of evolving exploration architectures, operations concepts, and vehicle designs. The purpose of implementing a similar evaluation process for the Phase 2 Habitation Concepts is to consistently evaluate different commercial partner ground prototypes to provide data-driven, actionable recommendations for Phase 3. This paper describes the process by which the ground test protocol was developed and the objectives, methods, and metrics by which the NextSTEP Phase 2 Habitation Concepts will be rigorously and systematically evaluated. The protocol has been developed using both a top-down and bottom-up approach. Top-down development began with the Human Exploration and Operations Mission Directorate (HEOMD) exploration objectives and ISS Exploration Capability Study Team (IECST) candidate flight objectives. Strategic questions and associated rationales, derived from these candidate architectural objectives, provide the framework by which the ground-test protocol will address the DSG stack elements and configurations, systems and subsystems, and habitation, science, and EVA functions. From these strategic questions, high-level functional requirements for the DSG were drafted and associated ground-test objectives and analysis protocols were established. Bottom-up development incorporated objectives from NASA SMEs in autonomy, avionics and software, communication, environmental control and life support systems, exercise, extravehicular activity, exploration medical operations, guidance navigation and control, human factors and behavioral performance, human factors and habitability, logistics, Mission Control Center operations, power, radiation, robotics, safety and mission assurance, science, simulation, structures, thermal, trash management, and vehicle health. Top-down and bottom-up objectives were integrated to form overall functional requirements - ground-test objectives and analysis mapping. From this mapping, ground-test objectives were organized into those that will be evaluated through inspection, demonstration, analysis, subsystem standalone testing, and human-in-the-loop (HITL) testing. For the HITL tests, mission-like timelines, procedures, and flight rules have been developed to directly meet ground test objectives and evaluate specific functional requirements. Data collected from these assessments will be analyzed to determine the acceptability of habitation element configurations and the combinations of capabilities that will result in the best habitation platform to be recommended by the test team for Phase 3.

The Importance of Minor Salivary Gland Biopsy in Sjögren Syndrome Diagnosis and the Clinicopathological Correlation.

PubMed

Serin, Gürdeniz; Karabulut, Gonca; Kabasakal, Yasemin; Kandiloğlu, Gülşen; Akalin, Taner

2016-01-01

Minor salivary gland biopsy is one of the objective tests used in the diagnosis of Sjögren syndrome. The aim of our study was to compare the clinical and laboratory data of primary and secondary Sjögren syndrome cases with a lymphocyte score 3 and 4 in the minor salivary gland biopsy. Data from a total of 2346 consecutive minor salivary gland biopsies were retrospectively evaluated in this study. Clinical and autoantibody characteristics of 367 cases with lymphocyte score 3 or 4 and diagnosed with primary or secondary Sjögren syndrome were compared. There was no difference between lymphocyte score 3 and 4 primary Sjögren syndrome patients in terms of dry mouth, dry eye symptoms and Schirmer test results but Anti-Ro and Antinuclear Antibody positivity was statistically significantly higher in cases with lymphocyte score 4 (p= 0.025, p= 0.001). Anti-Ro test results were also found to be statistically significantly higher in secondary Sjögren syndrome patients with lymphocyte score 4 (p= 0.048). In this study, the high proportion of cases with negative autoantibody but positive lymphocyte score is significant in terms of showing the contribution of minor salivary gland biopsy to Sjögren syndrome diagnosis. Lymphocyte score 3 and 4 cases were found to have similar clinical findings but a difference regarding antibody positivity in primary Sjögren syndrome. We believe that cases with lymphocyte score 4 may be Sjögren syndrome cases whose clinical manifestations are relatively established and higher autoantibody levels are therefore found.

Effects of resin luting agents and 1% NaOCl on the marginal fit of indirect composite restorations in primary teeth

PubMed Central

BORGES, Ana Flávia Sanches; SIMONATO, Luciana Estevam; PASCON, Fernanda Miori; KANTOWITZ, Kamila Rosamiglia; RONTANI, Regina Maria Puppin

2011-01-01

Objective The purpose of this study was to provide information regarding the marginal adaptation of composite resin onlays in primary teeth previously treated with 1% sodium hypochlorite (NaOCl) (pulp irrigant) using two different resin luting agents. Material and Methods Forty extracted sound primary molars had their crowns prepared in a standardized machine and were randomly divided into 4 groups (n=10): G1 (1% NaOCl irrigation+EnForce); G2 (EnForce); G3 (1% NaOCl irrigation+Rely X); G4 (Rely X). The onlays were made with Z250 composite resin on plaster models. After luting, the tooth/restoration set was stored in 100% relative humidity at 37ºC for 24 h and finished with Soflex discs. Caries Detector solution was applied at the tooth/restoration interface for 5 s. The specimens were washed and four digital photos of each tooth were then taken. The extents of the gaps were measured with Image Tool 3.0 software. The percentage data were submitted to a Kruskal-Wallis test (α=0.05). The Relative Risk test analyzed the chance of a gap presence correlated to each group. Results There were no statistically significant differences (p>0.05) among the groups. The relative risk test revealed that some groups were more apt to have a presence of gaps than others. Conclusion Neither the 1% NaOCl treatment nor the resin luting agents caused any alterations in the dental substrate that could have influenced the marginal adaptation of composite onlays in primary teeth. PMID:21986649

Revision Ligament Reconstruction Tendon Interposition for Trapeziometacarpal Arthritis: A Case-Control Investigation

PubMed Central

Sadhu, Anita; Calfee, Ryan P.; Guthrie, Andre; Wall, Lindley B.

2016-01-01

Purpose To test the null hypothesis that there is no difference in patient-reported and objective outcomes of revision ligament reconstruction and tendon interposition (LRTI) compared to primary LRTI. Methods This case-control investigation enrolled 10 patients who had undergone revision LRTI at a tertiary care center. All patients had previously undergone primary trapeziectomy with LRTI. Patients with a minimum of two years of follow-up were eligible. All patients completed an in-office study evaluation. Controls (treated only with primary LRTI) were matched from our practice to reach a 1:2 case to control ratio. Outcome measures included Michigan Hand Questionnaire (primary outcome), Quick Disability of the Arm, Hand, and Shoulder (QuickDASH) Questionnaire, VAS for pain and improvement, and physical examination. Statistical analyses were conducted to compare the patient groups. Results Revision LRTI patients reported significantly worse outcomes on all measured standardized questionnaires compared with primary patients. The Michigan Hand Questionnaire indicated worse overall outcomes (54 versus 79) as well as worse pain, appearance, and ability to complete activities of daily living. Revision LRTI patients also reported more impairment (QuickDASH 47 versus 23), greater pain (VAS pain 6.3 versus 1), and less improvement after surgery (VAS improvement 2.7 versus 7.9). There was also a significantly higher rate of patient-reported depression in the revision LRTI group (50% versus 10% of primary LRTI patients). We did not find a significant difference in objective outcomes of pinch strength, grip strength, and thumb palmar abduction between the two groups. Conclusion Following revision LRTI patient-reported outcomes indicate worse perceived function and greater pain than expected following primary LRTI despite similar motion and strength. Revision surgery can be offered in the setting of persistent or recurrent symptoms, but patients should be counseled that improvement of symptoms is unpredictable. PMID:27751779

Confirmatory testing in primary aldosteronism: extensive medication switching is not needed in all patients

PubMed Central

Solar, Miroslav; Malirova, Eva; Ballon, Marek; Pelouch, Radek; Ceral, Jiri

2012-01-01

Objective Confirmatory testing of suspected primary aldosteronism (PA) requires an extensive medication switch that can be difficult for patients with severe complicated hypertension and/or refractory hypokalemia. For this reason, we investigated the effect of chronic antihypertensive medication on confirmatory testing results. To allow the results to be interpreted, the reproducibility of confirmatory testing was also evaluated. Design and methods The study enrolled 114 individuals with suspected PA who underwent two confirmatory tests. The patients were divided into two groups. In Group A, both tests were performed on the guidelines-recommended therapy, i.e. not interfering with the renin–angiotensin–aldosterone system. In Group B, the first test was performed on chronic therapy with the exclusion of thiazides, loop diuretics, and aldosterone antagonists; and the second test was performed on guidelines-recommended therapy. Saline infusion, preceded by oral sodium loading, was used to suppress aldosterone secretion. Results Agreement in the interpretation of the two confirmatory tests was observed in 84 and 66% of patients in Groups A and B respectively. For all 20 individuals in Group A who ever had end-test serum aldosterone levels ≥240 pmol/l, aldosterone was concordantly nonsuppressible during the other test. Similarly, for all 16 individuals in Group B who had end-test serum aldosterone levels ≥240 pmol/l on modified chronic therapy, aldosterone remained nonsuppressible with guidelines-recommended therapy. Conclusion Confirmatory testing performed while the patient is on chronic therapy without diuretics and aldosterone antagonists can confirm the diagnosis of PA, provided serum aldosterone remains markedly elevated at the end of saline infusion. PMID:22253400

Uptake of cystic fibrosis testing in primary care: supply push or demand pull?

PubMed Central

Bekker, H; Modell, M; Denniss, G; Silver, A; Mathew, C; Bobrow, M; Marteau, T

1993-01-01

OBJECTIVE--To determine the acceptability and feasibility of screening for carriers of cystic fibrosis in a primary care setting. DESIGN--Follow up study over 15 months of patients offered carrier testing by mouthwash. SETTING--A general practice in inner London. SUBJECTS--5529 patients aged 18-45 invited by various methods and combinations of methods (letter, booklet, personal approach) for testing. MAIN OUTCOME MEASURES--Uptake of screening, anxiety, and knowledge of test. RESULTS--957 (17%) invitees were screened over the 15 months. 28 carriers and no carrier couples were detected. Uptake rates were 12% (59/502 patients) among patients invited by letter and tested by appointment; 9% (47/496) among patients invited by letter, with leaflet, and tested by appointment; 4% (128/2953) among patients invited by letter six weeks before the end of the study and tested by appointment; 17% (81/471) among patients offered passive opportunistic testing; 70% (453/649) among patients offered active opportunistic testing; and 25% (22/88) among patients offered active opportunistic testing by appointment. A short term rise in anxiety among those given a positive test result had dissipated by three months. At three months about one fifth and one third of those given positive and negative results respectively did not understand their results correctly. CONCLUSION--These results suggest that the strongest variable in determining uptake of screening is the active approach by a health professional offering immediate testing. It remains to be resolved whether the high uptake rates achieved by active recruitment indicate a supply push for this new test rather than a demand from the population. PMID:8329922

Use of Laser Speckle Contrast Imaging to Assess Digital Microvascular Function in Primary Raynaud Phenomenon and Systemic Sclerosis: A Comparison Using the Raynaud Condition Score Diary.

PubMed

Pauling, John D; Shipley, Jacqueline A; Hart, Darren J; McGrogan, Anita; McHugh, Neil J

2015-07-01

Evaluate objective assessment of digital microvascular function using laser speckle contrast imaging (LSCI) in a cross-sectional study of patients with primary Raynaud phenomenon (RP) and systemic sclerosis (SSc), comparing LSCI with both infrared thermography (IRT) and subjective assessment using the Raynaud Condition Score (RCS) diary. Patients with SSc (n = 25) and primary RP (n = 18) underwent simultaneous assessment of digital perfusion using LSCI and IRT with a cold challenge on 2 occasions, 2 weeks apart. The RCS diary was completed between assessments. The relationship between objective and subjective assessments of RP was evaluated. Reproducibility of LSCI/IRT was assessed, along with differences between primary RP and SSc, and the effect of sex. There was moderate-to-good correlation between LSCI and IRT (Spearman rho 0.58-0.84, p < 0.01), but poor correlation between objective assessments and the RCS diary (p > 0.05 for all analyses). Reproducibility of IRT and LSCI was moderate at baseline (ICC 0.51-0.63) and immediately following cold challenge (ICC 0.56-0.86), but lower during reperfusion (ICC 0.3-0.7). Neither subjective nor objective assessments differentiated between primary RP and SSc. Men reported lower median daily frequency of RP attacks (0.82 vs 1.93, p = 0.03). Perfusion using LSCI/IRT was higher in men for the majority of assessments. Objective and subjective methods provide differing information on microvascular function in RP. There is good convergent validity of LSCI with IRT and acceptable reproducibility of both modalities. Neither subjective nor objective assessments could differentiate between primary RP and SSc. Influence of sex on subjective and objective assessment of RP warrants further evaluation.

The influence of chronotype and intelligence on academic achievement in primary school is mediated by conscientiousness, midpoint of sleep and motivation.

PubMed

Arbabi, Talat; Vollmer, Christian; Dörfler, Tobias; Randler, Christoph

2015-04-01

Individuals differ in their timing of sleep (bed times, rise times) and in their preference for morning or evening hours. Previous work focused on the relationship between academic achievement and these variables in secondary school students. The main aim of the study is to investigate the relationship between chronotype and academic achievement in 10-year-old children (n = 1125) attending 4th grade of primary school. They filled a cognitive test (Culture Fair Intelligence Test, CFT 20-R) and questions about rise times and bed times, academic achievement, conscientiousness and motivation. We used the "scales for the assessment of learning and performance motivation" (SELLMO; Skalen zur Erfassung der Lern- und Leistungsmotivation for motivation), the short version of the Five-Factor Personality Inventory Children (FFPI-C) to measure conscientiousness, and the Composite Scale of Morningness (CSM) to assess morningness-eveningness. Mean CSM score was 37.84 ± 6.66, midpoint of sleep was 1:36 ± 00:25 and average sleep duration (time in bed) was 10:15 ± 0:48. Morningness orientation was positively related to intelligence, conscientiousness and learning objectives. Eveningness orientation was related to avoidance performance objectives and work avoidance. Early midpoint of sleep, conscientiousness and intelligence were associated with better grades. The multivariate model showed that intelligence was the strongest predictor of good grades. Conscientiousness, motivation, younger age and an earlier midpoint of sleep were positively related to good grades. This is the first study in primary school pupils, and it shows that the relationship between evening orientation and academic achievement is already prevalent at this age even when controlling for important predictors of achievement.

Cancer Patients Perceptions Regarding the Value of the Physical Examination: A Survey Study

PubMed Central

Kadakia, Kunal C.; Hui, David; Chisholm, Gary B.; Frisbee-Hume, Susan E.; Williams, Janet L.; Bruera, Eduardo

2017-01-01

Background Despite its clinical utility, progressive reliance on technology can lead to devaluing the physical examination in patients with advanced cancer. The primary objective was to determine whether these patients have a positive or negative perception of the physical examination. Secondarily, to determine if these perceptions are related to interpersonal/relational values (symbolic) or diagnostic/objective values (pragmatic). Methods One-hundred and fifty patients with cancer receiving concurrent oncology and palliative care were administered a 26-item survey regarding their overall perception of the physical examination. The primary outcome, patient responses to “I believe my experience while undergoing physical examinations has been overall: very negative (−5) to very positive (+5)”, was analyzed using the Sign test. Other items were predefined as symbolic or pragmatic statements and responses from strongly disagree (1) to strongly agree (5) were further analyzed. Multivariable logistic regression was utilized to test for associations between baseline characteristics and the primary outcome. Results Most patients (83%) found the overall experience of being examined to be highly positive (median=4, interquartile range [IQR]=2–5, p=<0.0001). Patients valued both the pragmatic (median=5, IQR=4–5) and symbolic (median=4, IQR=4–5) aspects of the physical examination. Increasing age was independently associated with a more positive perception of the physical examination (odds ratio=1.07 per year, 95% confidence interval 1.02–1.12, p=0.01). Conclusions Patients with advanced cancer find the physical examination to be a highly positive aspect of their care. These benefits are perceived as having both symbolic and pragmatic value. The physical examination should remain a cornerstone of clinical encounters. PMID:24899511

A clinical study of the LiVac laparoscopic liver retractor system.

PubMed

Gan, Philip; Bingham, Judy

2016-02-01

All retractors for laparoscopic operations on the gallbladder or stomach apply an upward force to the under-surface of the liver or gallbladder, most requiring an additional skin incision. The LiVac laparoscopic liver retractor system (LiVac retractor) comprises a soft silicone ring attached to suction tubing and connected to a regulated source of suction. The suction tubing extends alongside existing ports. When placed between the liver and diaphragm, and suction applied, a vacuum is created within the ring, keeping these in apposition. Following successful proof-of-concept animal testing, a clinical study was conducted to evaluate the performance and safety of the retractor in patients. The study was a dual-centre, single-surgeon, open-label study and recruited ten patients scheduled to undergo routine upper abdominal laparoscopic surgery including cholecystectomy, primary gastric banding surgery or fundoplication. The study was conducted at two sites and was approved by the institutions' ethics committees. The primary objective of the study was to evaluate the performance of the LiVac retractor in patients undergoing upper abdominal single- or multi-port laparoscopic surgery. Performance was measured by the attainment of milestones for the retractor and accessory bevel, where used, and safety outcomes through the recording of adverse events, physical parameters, pain scales, blood tests and a post-operative liver ultrasound. The LiVac retractor achieved both primary and secondary performance and safety objectives in all patients. No serious adverse events and no device-related adverse events or device deficiencies were reported. The LiVac retractor achieved effective liver retraction without clinically significant trauma and has potential application in multi- or single-port laparoscopic upper abdominal surgery. As a separate incision is not required, the use of the LiVac retractor in multi-port surgery therefore reduces the number of incisions.

Creating a Test Validated Structural Dynamic Finite Element Model of the X-56A Aircraft

NASA Technical Reports Server (NTRS)

Pak, Chan-Gi; Truong, Samson

2014-01-01

Small modeling errors in the finite element model will eventually induce errors in the structural flexibility and mass, thus propagating into unpredictable errors in the unsteady aerodynamics and the control law design. One of the primary objectives of the Multi Utility Technology Test-bed, X-56A aircraft, is the flight demonstration of active flutter suppression, and therefore in this study, the identification of the primary and secondary modes for the structural model tuning based on the flutter analysis of the X-56A aircraft. The ground vibration test-validated structural dynamic finite element model of the X-56A aircraft is created in this study. The structural dynamic finite element model of the X-56A aircraft is improved using a model tuning tool. In this study, two different weight configurations of the X-56A aircraft have been improved in a single optimization run. Frequency and the cross-orthogonality (mode shape) matrix were the primary focus for improvement, while other properties such as center of gravity location, total weight, and offdiagonal terms of the mass orthogonality matrix were used as constraints. The end result was a more improved and desirable structural dynamic finite element model configuration for the X-56A aircraft. Improved frequencies and mode shapes in this study increased average flutter speeds of the X-56A aircraft by 7.6% compared to the baseline model.

The Analysis of the Relationship between Primary Learning Styles and Learning Objects in an Online Environment

ERIC Educational Resources Information Center

Özdemir, Muzaffer

2016-01-01

This study investigates the relationships between the primary learning styles of students and different learning objects presented simultaneously in an online learning environment in the context of the usage levels of these objects. A total of 103 sophomores from a Turkish State University participated in the study. Felder-Solomon Index of…

The PLUNGE randomized controlled trial: evaluation of a games-based physical activity professional learning program in primary school physical education.

PubMed

Miller, Andrew; Christensen, Erin M; Eather, Narelle; Sproule, John; Annis-Brown, Laura; Lubans, David Revalds

2015-05-01

To evaluate the efficacy of the Professional Learning for Understanding Games Education (PLUNGE) program on fundamental movement skills (FMS), in-class physical activity and perceived sporting competence. A cluster-randomized controlled trial involving one year six class each from seven primary schools (n=168; mean age=11.2 years, SD=1.0) in the Hunter Region, NSW, Australia. In September (2013) participants were randomized by school into the PLUNGE intervention (n=97 students) or the 7-week wait-list control (n=71) condition. PLUNGE involved the use of Game Centered curriculum delivered via an in-class teacher mentoring program. Students were assessed at baseline and 8-week follow-up for three object control FMS (Test of Gross Motor Development 2), in-class physical activity (pedometer steps/min) and perceived sporting competence (Self-perception Profile for Children). Linear mixed models revealed significant group-by-time intervention effects (all p<0.05) for object control competency (effect size: d=0.9), and in-class pedometer steps/min (d=1.0). No significant intervention effects (p>0.05) were observed for perceived sporting competence. The PLUNGE intervention simultaneously improved object control FMS proficiency and in-class PA in stage three students. Copyright © 2015 Elsevier Inc. All rights reserved.

Further Validation of Simulated Dynamic Interface Testing Techniques as a Tool in the Forecasting of Air Vehicle Deck Limits

DTIC Science & Technology

2010-01-01

UAV Autonomy program which includes intelligent reasoning for autonomy, technologies to enhance see and avoid capabilities, object identification ...along the ship’s base recovery course (BRC). The pilot then flies toward the stern of the ship, aligning his approach path with the ship’s lineup line...quiescent point identification . CONCLUSIONS The primary goal for conducting dynamic interface analysis is to expand existing operating envelopes and

Proceedings of the Annual Conference of the Military Testing Association (22nd) held in Toronto, Ontario, Canada, 27-31 October 1980. Volume 2.

DTIC Science & Technology

1980-12-01

instructional skills and tasks viewed in greater accord with student learning and retention performance objectives, their instruction has gained added...research reports to evaluate higher levels of cognitive learning and communications abilities . However, the primary interest of this paper is the use of...would gain freedom of expression in answering items. c. Students could better demonstrate higher levels of cognitive learning . d. Students could

One-dimensional representation of Earth to show SRTM coverage

NASA Image and Video Library

2000-02-04

JSC2000E01555 (January 2000) --- A one-dimensional representation of Earth indicates only a portion of the total anticipated coverage area for the Shuttle Radar Topography Mission (SRTM). The primary objective of SRTM is to acquire a high-resolution topographic map of the Earth's land mass (between 60 degrees north and 56 degrees south latitude) and to test new technologies for deployment of large rigid structures and measurement of their distortions to extremely high precision.

Space Station CMIF extended duration metabolic control test

NASA Technical Reports Server (NTRS)

Schunk, Richard G.; Bagdigian, Robert M.; Carrasquillo, Robyn L.; Ogle, Kathryn Y.; Wieland, Paul O.

1989-01-01

The Space Station Extended Duration Metabolic Control Test (EMCT) was conducted at the MSFC Core Module Integration Facility. The primary objective of the EMCT was to gather performance data from a partially-closed regenerative Environmental Control and Life Support (ECLS) system functioning under steady-state conditions. Included is a description of the EMCT configuration, a summary of events, a discussion of anomalies that occurred during the test, and detailed results and analysis from individual measurements of water and gas samples taken during the test. A comparison of the physical, chemical, and microbiological methods used in the post test laboratory analyses of the water samples is included. The preprototype ECLS hardware used in the test, providing an overall process description and theory of operation for each hardware item. Analytical results pertaining to a system level mass balance and selected system power estimates are also included.

Pretest analysis document for Test S-NH-1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Owca, W.A.

This report documents the pretest analysis calculation completed with the RELAP5/MOD2/CY3601 code for Semiscale MOD-2C Test S-NH-1. The test will simulate the shear of a small diameter penetration of a cold leg, equivalent to 0.5% of the cold leg flow area. The high pressure injection system is assumed to be inoperative throughout the transient. The recovery procedure consists of latching open both steam generator ADV's while feeding with auxiliary feedwater, and accumulator operation. Recovery will be initiated upon a peak cladding temperature of 811 K (1000/sup 0/F). The test will be terminated when primary pressure has been reduced to themore » low pressure injection system setpoint of 1.38 MPa (200 psia). The calculated results indicate that the test objectives can be achieved and the proposed test scenario poses no threat to personnel or to plant integrity. 12 figs.« less

An Examination of the Role of Nursery Education on Primary School Pupils in Nigeria

ERIC Educational Resources Information Center

Oniwon, H. O. Evelyn

2015-01-01

This study examines the role of Nursery education among primary school pupils. The sole objective of the study was to find out the differences in academic achievement between primary school pupils who received nursery education and those who did not. Descriptive survey research design was adopted to achieve the study objective. Consequently, 20…

Neural-Thyroid Interaction on Skeletal Isomyosin in Zero Gravity

NASA Technical Reports Server (NTRS)

Baldwin, Kenneth M.

2000-01-01

The primary goal of the project was to develop a ground based model to first study the role of the nerve and of thyroid hormone (T3) in the regulation of body growth and skeletal muscle growth and differentiation in rodents. A primary objective was to test the hypothesis that normal weight bearing activity is essential for the development of antigravity, slow twitch skeletal muscle and the corresponding slow myosin heavy chain (MHC) gene; whereas, T3 was obligatory for general body and muscle growth and the establishment of fast MHC phenotype in typically fast locomoter muscles. These ground based experiments would provide both the efficacy and background for a spaceflight experiment (referred to as the Neurolab Mission) jointly sponsored by the NIH and NASA.

Results of experimental tests in the MSFC 14 x 14 inch trisonic wind tunnel on a .004 scale model space shuttle integrated vehicle 5 (model 77-O, 74-TS) to relieve wing loads during ascent (IA71)

NASA Technical Reports Server (NTRS)

Allen, E. C.

1975-01-01

Results are presented for the 0.004-scale orbiter, external tank, and solid rocket boosters combined as an integrated vehicle in a trisonic wind tunnel at mach numbers from 0.6 to 2.0. The primary test objective was to determine the effectiveness of several methods in relieving the Orbiter wing bending and torsion loads and moments during launch. Effects of several midwing spoilers, termed flipper doors, and Orbiter/external tank incidence were investigated. Photographs are included.

Advanced Hypervelocity Aerophysics Facility Workshop

NASA Technical Reports Server (NTRS)

Witcofski, Robert D. (Compiler); Scallion, William I. (Compiler)

1989-01-01

The primary objective of the workshop was to obtain a critical assessment of a concept for a large, advanced hypervelocity ballistic range test facility powered by an electromagnetic launcher, which was proposed by the Langley Research Center. It was concluded that the subject large-scale facility was feasible and would provide the required ground-based capability for performing tests at entry flight conditions (velocity and density) on large, complex, instrumented models. It was also concluded that advances in remote measurement techniques and particularly onboard model instrumentation, light-weight model construction techniques, and model electromagnetic launcher (EML) systems must be made before any commitment for the construction of such a facility can be made.

A gravitational test of wave reinforcement versus fluid density models

NASA Technical Reports Server (NTRS)

Johnson, Jacqueline Umstead

1990-01-01

Spermatozoa, protozoa, and algae form macroscopic patterns somewhat analogous to thermally driven convection cells. These bioconvective patterns have attracted interest in the fluid dynamics community, but whether in all cases these waves were gravity driven was unknown. There are two conflicting theories, one gravity dependent (fluid density model), the other gravity independent (wave reinforcement theory). The primary objectives of the summer faculty fellows were to: (1) assist in sample collection (spermatozoa) and preparation for the KC-135 research airplane experiment; and (2) to collaborate on ground testing of bioconvective variables such as motility, concentration, morphology, etc., in relation to their macroscopic patterns. Results are very briefly given.

Design review of fluid film bearing testers

NASA Technical Reports Server (NTRS)

Scharrer, Joseph K.

1993-01-01

The designs of three existing testers (Hybrid Bearing Tester, OTV Bearing Tester, and Long Life Bearing Tester) owned by NASA were reviewed for their capability to serve as a multi-purpose cryogenic fluid film bearing tester. The primary tester function is the validation of analytical predictions for fluid film bearing steady state and dynamic performance. Evaluation criteria were established for test bearing configurations, test fluids, instrumentation, and test objectives. Each tester was evaluated with respect to these criteria. A determination was made of design improvements which would allow the testers to meet the stated criteria. The cost and time required to make the design changes were estimated. A recommendation based on the results of this study was made to proceed with the Hybrid Bearing Tester.

Investigation of outside visual cues required for low speed and hover

NASA Technical Reports Server (NTRS)

Hoh, R. H.

1985-01-01

Knowledge of the visual cues required in the performance of stabilized hover in VTOL aircraft is a prerequisite for the development of both cockpit displays and ground-based simulation systems. Attention is presently given to the viability of experimental test flight techniques as the bases for the identification of essential external cues in aggressive and precise low speed and hovering tasks. The analysis and flight test program conducted employed a helicopter and a pilot wearing lenses that could be electronically fogged, where the primary variables were field-of-view, large object 'macrotexture', and fine detail 'microtexture', in six different fields-of-view. Fundamental metrics are proposed for the quantification of the visual field, to allow comparisons between tests, simulations, and aircraft displays.

Something Old, Something New: Using Family History and Genetic Testing to Diagnose and Manage Athletes with Inherited Cardiovascular Disease.

PubMed

Thomas, Matthew J; Battle, Robert W

2015-07-01

A primary objective of the preparticipation physical examination is to identify athletes at increased risk for sudden cardiac arrest (SCA). Review of an athlete's family history may identify those at risk for SCA. Genetic testing for inherited cardiovascular disease has emerged as a valuable addition to the repertoire of cardiologists facing the decision of clearing athletes with concerning clinical signs and/or family histories. Genetic testing may lead to various outcomes for an athlete including: reassurance, diagnosis in those with borderline clinical features, finding disease predisposition prior to the onset of clinical signs (ie, genotype-positive/phenotype-negative), or continued uncertainty. Copyright © 2015 Elsevier Inc. All rights reserved.

Evaluation of a 40 to 1 scale model of a low pressure engine

NASA Technical Reports Server (NTRS)

Cooper, C. E., Jr.; Thoenes, J.

1972-01-01

An evaluation of a scale model of a low pressure rocket engine which is used for secondary injection studies was conducted. Specific objectives of the evaluation were to: (1) assess the test conditions required for full scale simulations; (2) recommend fluids to be used for both primary and secondary flows; and (3) recommend possible modifications to be made to the scale model and its test facility to achieve the highest possible degree of simulation. A discussion of the theoretical and empirical scaling laws which must be observed to apply scale model test data to full scale systems is included. A technique by which the side forces due to secondary injection can be analytically estimated is presented.

Results of transonic tests in the NASA/MSFC 14-inch trisonic wind tunnel on a 0.004-scale model (74-OTS) space shuttle launch vehicle (FA25)

NASA Technical Reports Server (NTRS)

Lundy, T. E.

1979-01-01

The primary objective of the test was to determine the aerodynamic increments due to the attach structure. Secondary objectives were to determine the effects of: (1) orbiter nose mold line changes; (2) wire bundle fairings on data measurements; and (3) flow angularity. The scale model was tested over the Mach range from 0.60 to 1.25 at angles of attack and sideslip from -8 to +8 deg. The total pressure was 22 psia for all runs. Six-component orbiter data were obtained from a balance in the orbiter which was sting supported. The external tank was attached to the solid rocket booster, each of which was sting supported. An alternate two sting/two balance arrangement was also tested with a single sting and balance in the external tank measuring combined ET/SRB aero data replacing the two stings in the SRB's. Two runs were also made at Mach number 4.96 with the two SRB's removed. The aerodynamic coefficients obtained are tabulated as a function of angle of attack or sideslip for each Mach number value.

Acoustic Treatment Design Scaling Methods. Volume 1; Overview, Results, and Recommendations

NASA Technical Reports Server (NTRS)

Kraft, R. E.; Yu, J.

1999-01-01

Scale model fan rigs that simulate new generation ultra-high-bypass engines at about 1/5-scale are achieving increased importance as development vehicles for the design of low-noise aircraft engines. Testing at small scale allows the tests to be performed in existing anechoic wind tunnels, which provides an accurate simulation of the important effects of aircraft forward motion on the noise generation. The ability to design, build, and test miniaturized acoustic treatment panels on scale model fan rigs representative of the fullscale engine provides not only a cost-savings, but an opportunity to optimize the treatment by allowing tests of different designs. The primary objective of this study was to develop methods that will allow scale model fan rigs to be successfully used as acoustic treatment design tools. The study focuses on finding methods to extend the upper limit of the frequency range of impedance prediction models and acoustic impedance measurement methods for subscale treatment liner designs, and confirm the predictions by correlation with measured data. This phase of the program had as a goal doubling the upper limit of impedance measurement from 6 kHz to 12 kHz. The program utilizes combined analytical and experimental methods to achieve the objectives.

Comparison of the pattern, efficacy, and tolerability of self-medicated drugs in primary dysmenorrhea: a questionnaire based survey.

PubMed

Sugumar, Ramya; Krishnaiah, Vasundara; Channaveera, Gokul Shetty; Mruthyunjaya, Shilpa

2013-01-01

To compare the pattern, efficacy, and tolerability of self-medicated drugs and to assess the adequacy of their dose in primary dysmenorrhea (PD). A survey using a self-developed, validated, objective, and structured questionnaire as a tool was conducted among subjects with PD. Statistical analysis was carried out using Chi-square test and ANOVA with post-hoc Tuckey's test. Out of 641 respondents, 42% were self-medicated. The pattern of drugs used was: Dicyclomine, an unknown drug, mefenamic acid, mefenamic acid + dicyclomine, and metamizole by 35%, 29%, 26%, 9%, and 1% of respondents, respectively. Mefenamic acid + dicyclomine, the combination was the most efficacious in comparison to other drugs in moderate to severe dysmenorrhea. There was better tolerability with mefenamic acid + dicyclomine group compared to other drugs. Sub-therapeutic doses were used by 86% of self-medicating respondents. The prevailing self-medication practices were inappropriate in a substantial proportion of women with inadequate knowledge regarding appropriate drug choice, therapeutic doses, and their associated side effects.

Confrontation Naming and Reading Abilities at Primary School: A Longitudinal Study

PubMed Central

Savelli, Enrico; Termine, Cristiano

2015-01-01

Background. Confrontation naming tasks are useful in the assessment of children with learning and language disorders. Objectives. The aims of this study were (1) providing longitudinal data on confrontation naming; (2) investigating the role of socioeconomic status (SES), intelligence, age, and gender in confrontation naming; (3) identifying relationship between confrontation naming and reading abilities (fluency, accuracy, and comprehension). Method. A five-year longitudinal investigation of confrontation naming (i.e., the Boston Naming Test (BNT)) in a nonclinical sample of Italian primary school children was conducted (n = 126), testing them at the end of each school year, to assess nonverbal intelligence, confrontation naming, and reading abilities. Results. Performance on the BNT emerged as a function of IQ and SES. Significant correlations between confrontation naming and reading abilities, especially comprehension, were found; BNT scores correlated better with reading fluency than with reading accuracy. Conclusions. The longitudinal data obtained in this study are discussed with regard to reading abilities, intelligence, age, gender, and socioeconomic status. PMID:26124541

Iridotomy to slow progression of angle-closure glaucoma

PubMed Central

Le, Jimmy T; Rouse, Benjamin; Gazzard, Gus

2016-01-01

This is the protocol for a review and there is no abstract. The objectives are as follows: The primary objective is to assess the role of iridotomy-compared with observation-in the prevention of visual field loss for individuals who have primary angle closure or primary angle-closure glaucoma in at least one eye. We will also examine the role of iridotomy in the prevention of elevated intraocular pressure (IOP) in individuals with narrow angles (primary angle-closure suspect) in at least one eye. PMID:27551238

Care Coordination Associated with Improved Timing of Newborn Primary Care Visits.

PubMed

Goyal, Neera K; Hall, Eric S; Kahn, Robert S; Wexelblatt, Scott L; Greenberg, James M; Samaan, Zeina M; Brown, Courtney M

2016-09-01

Objective Despite practice recommendations that all newborns be examined within 3-5 days after discharge, many are not seen within this timeframe. Our objective was to determine the association between care coordination and timing of newborn follow-up. Methods This retrospective study evaluated 6251 newborns from eight maternity hospitals who scheduled a primary care appointment at one of two academic pediatric practices over 3.5 years. Two programs were sequentially implemented: (1) newborn discharge coordination, and (2) primary care intake coordination. Primary outcome was days between discharge and follow-up, dichotomized as ≤ or >5 days. Number of rescheduled appointments and loss to follow-up were also assessed. Adjusted relative risks (RR) and odds ratios (OR) were determined by piecewise generalized linear and logistic regression. Results Among 5943 newborns with a completed visit, 52.9 % were seen within 5 days of discharge (mean 6.7 days). After multivariable adjustment, the pre-exposure period (8 months) demonstrated a downward monthly trend in completing early follow-up (RR 0.93, p < 0.001). After initial program implementation, we observed a 3 % monthly increase (RR 1.03, p < 0.001 for test of slope change from pre-exposure to post-exposure), such that likelihood of recommended follow-up increased by roughly 72 % after discharge coordinator implementation and roughly 33 % after primary care coordinator implementation. The latter was also associated with a 13 % monthly decrease in odds of loss to follow-up (OR 0.87, p < 0.001). Conclusions for Practice Care coordination increases adherence among low income families to recommended newborn follow-up after birth hospitalization.

TVT and TVT-O for surgical treatment of primary stress urinary incontinence: prospective randomized trial.

PubMed

Krofta, Ladislav; Feyereisl, Jaroslav; Otcenásek, Michal; Velebil, Petr; Kasíková, Eva; Krcmár, Michal

2010-02-01

A study was conducted to compare the efficacy and complications of TVT and TVT-O. This study is a prospective randomized trial involving 300 women with primary SUI; 149 received TVT, and 151 patients were treated with TVT-O. At the 1 year follow-up, 141 TVT patients and 147 TVT-O patients (dropout, 5.3% and 2.6%) were evaluated using urodynamic studies, validated questionnaires, and a 1-h pad test. The mean operating time was shorter in the TVT-O group (p < 0.001). Urinary retention was not significantly different (p > 0.05). Inner thigh discomfort was reported by 5.4% of TVT-O patients. In the TVT and the TVT-O groups, respectively, 90.1% and 88.4% women were objectively cured. The satisfaction with the surgical outcome reflects the significant decrease in the questionnaire mean symptom scores in both groups. Postoperative de novo urgency was significantly more common in the TVT-O patients (p = 0.015). The groups showed comparable objective and subjective cure rates.

Fluid Acquisition and Resupply Experiments on Space Shuttle Flights STS-53 and STS-57

NASA Technical Reports Server (NTRS)

Dominick, S. M.; Tegart, J. R.; Driscoll, S. L.; Sledd, J. D.; Hastings, L. J.

2011-01-01

The Fluid Acquisition and Resupply Experiment (FARE) program, managed by the Marshall Space Flight Center Space Propulsion Branch with Martin Marietta Civil Space and Communications as the contractor, consisted of two flights designated FARE I and FARE II. FARE I flew in December 1992 on STS-53 with a screen channel liquid acquisition device (LAD) and FARE II flew in June 1993 on STS-57 with a vane-type LAD. Thus, the FARE I and II flights represent the two basic LAD categories usually considered for in-space fluid management. Although both LAD types have been used extensively, the usefulness of the on-orbit data has been constrained by the lack of experimentation beyond predicted performance limits, including both propellant fill and expulsion. Therefore, the FARE tests were designed to obtain data that would satisfy two primary objectives: (1) Demonstrate the performance of the two types of LADs, screen channel and vane, and (2) support the anchoring of analytical models. Both flights were considered highly successful in meeting these two primary objectives.

The ionospheric impact on GPS performance in southern polar region

USGS Publications Warehouse

Hong, C.-K.; Grejner-Brzezinska, D. A.; Arslan, N.; Willis, M.; Hothem, L.

2006-01-01

The primary objective of this paper is to present the results of the study of the effects of varying ionospheric conditions on the GPS signal tracking in the southern polar region. In the first stage of this study, the data collected by the OSU/USGS team in October-November 2003 within the TAMDEF (Transantarctic Mountains Deformation) network were used together with some IGS Antarctic stations to study the effect of severe ionospheric storms on GPS hardware. Note that TAMDEF is a joint USGS/OSU project with the primary objective of measuring crustal motion in the Transantarctic Mountains of Southern Victoria Land using GPS techniques. This study included ten Antarctic stations equipped with different dual-frequency GPS hardware, and the data were evaluated for two 24-hour periods of severe ionospheric storm (2003/10/29) and moderate ionospheric conditions (minor storm of 2003/11/11). The results of this study were presented at the LAG Assembly in Cairns, Australia (Grejner-Brzezinska et al., 2005). Additional tests, in a more controlled environment, were carried out at the US Antarctic station, McMurdo, between January 10 and February 6, 2006, under varying ionospheric conditions, where several different types of receivers were connected to the same antenna located on the rooftop of the Crary Laboratory (the primary test site). In this scenario, each antenna was subject to identical ionospheric effects during each day of the test, and no spatial decorrelation effects were present, as seen in the previous study, due to the spatial separation of the receivers tested. It should be noted, however, that no moderate or severe ionospheric storms occurred during the experiment, so, unfortunately, this type of conditions was not tested here. The test was repeated with different receivers connected to different antenna types; a total of four 5-day sessions were carried out. The following receiver types were used at the primary site: Trimble 5700, Ashtech Z-Surveyor, JNS Euro-80 and Novatel DL-4, with the following antennas: Trimble Zephyr Geodetic, Ashtech D/M and Ashtech E/M chokering. In addition, data collected by the MCM4 IGS station, MCMD UNAVCO station, and CRAR USGS station, all located within 300 m from the primary test site, were used in the analyses. These stations were equipped with the following receiver/antenna combinations: ADA SNR-12/AOAD/MJT chokering (MCM4), Trimble NETRS/AOAD/MJT chokering (MCMD), and TPS ODYSEY_E/JPSREGANT_DD_E (CRAR). The UNAVCO TEQC software was used to carry out the analyses. Depending on the data sampling rate and the mask angle, the expected numbers of observations per receiver/satellite were compared to the actual number of measurements collected during the ionospheric events, with a special emphasis on L2 data. A total number of cycle slips and losses of lock were computed and compared among the hardware types. The results presented here indicate that there is no significant effects on the GPS receivers during minor ionospheric storms (Kp<5). However, the results reported in ibid, indicate significant differences in the hardware performance under severe ionospheric storms. Thus, careful hardware selection is needed to assure data quality/continuity when observations may be affected by severe ionospheric disturbances, while under calm to minor ionospheric activity level there is no significant difference in performance among the hardware tested here.

Primary Teachers' Conceptions about the Concept of Volume: The Case of Volume-Measurable Objects

ERIC Educational Resources Information Center

Saiz, Mariana

2003-01-01

In this paper part of the results obtained by a research project called "Primary Teachers' Thinking about the Concept of Volume and its Teaching", performed from 1997 to 2001, are reported. This paper focuses in one of the two main objectives of the aforementioned research: To describe the mental object volume of the participant…

Effect assessment of "film coating and packaging" on the photo-stability of highly photo-labile antihypertensive products.

PubMed

Mukharya, Amit; Patel, Paresh U; Chaudhary, Shivang

2013-04-01

Lacidipine (LCDP) is chemically a "1, 4-dihydropyridine derivative" Ca+(2) channel blocker used as an antihypertensive. Type and extent of packaging have a strong influence on the photo-stability of the 1,4-dihydropyridine derivatives. In standard, light protection of drug substance/drug product can be obtained either by use of an opaque additive in the formulation that competitively absorbs or reflects light reaching the sample and/or by blocking the access of light to the drug through external protection by packaging. External protection by covering tablets with an opaque film coating involving a light-reflecting inorganic pigment such as titanium dioxide and/or by using an opaque impermeable packaging material was an appropriate suitable option for establishing photo-stability. Thus, the main objective of the present study was to optimize the % level of film coating in LCDP core tablets, and selection of a final packaging material and its respective extent, that is, primary, secondary and/or tertiary packaging, for LCDP tablets. The main objective (% level of film coating) was optimized by directly exposing core tablets, 1% w/w, 2% w/w and 3% w/w film-coated tablets, to a light source as per Option-2 of ICH Q1B and its comparative analysis at the end of light exposure testing. The other objective (extent of drug product packaging) was established successfully by assessing whether or not an acceptable change has occurred at the end of the light exposure testing of the LCDP film-coated tablets in a direct exposure study or a primary immediate pack and/or secondary marketing pack.

Arthroscopic Surgical Procedures Versus Sham Surgery for Patients With Femoroacetabular Impingement and/or Labral Tears: Study Protocol for a Randomized Controlled Trial (HIPARTI) and a Prospective Cohort Study (HARP).

PubMed

Risberg, May Arna; Ageberg, Eva; Nilstad, Agnethe; Lund, Bent; Nordsletten, Lars; Løken, Sverre; Ludvigsen, Tom; Kierkegaard, Signe; Carsen, Sasha; Kostogiannis, Ioannis; Crossley, Kay M; Glyn-Jones, Sion; Kemp, Joanne L

2018-04-01

Study Design Study protocol for a randomized controlled trial and a prospective cohort. Background The number of arthroscopic surgical procedures for patients with femoroacetabular impingement syndrome (FAIS) has significantly increased worldwide, but high-quality evidence of the effect of such interventions is lacking. Objectives The primary objective will be to determine the efficacy of hip arthroscopic procedures compared to sham surgery on patient-reported outcomes for patients with FAIS (HIP ARThroscopy International [HIPARTI] Study). The secondary objective will be to evaluate prognostic factors for long-term outcome after arthroscopic surgical interventions in patients with FAIS (Hip ARthroscopy Prospective [HARP] Study). Methods The HIPARTI Study will include 140 patients and the HARP Study will include 100 patients. The international Hip Outcome Tool-33 will be the primary outcome measure at 1 year. Secondary outcome measures will be the Hip disability and Osteoarthritis Outcome Score, Arthritis Self-Efficacy Scale, fear of movement (Tampa Scale of Kinesiophobia), Patient-Specific Functional Scale, global rating of change score, and expectations. Other outcomes will include active hip range of motion, hip muscle strength tests, functional performance tests, as well as radiological assessments using radiographs and magnetic resonance imaging. Conclusion To determine the true effect of surgery, beyond that of placebo, double-blinded placebo-controlled trials including sham surgery are needed. The HIPARTI Study will direct future evidence-based treatment of FAIS. Predictors for long-term development and progression of degenerative changes in the hip are also needed for this young patient group with FAIS; hence, responders and nonresponders to treatment could be determined. J Orthop Sports Phys Ther 2018;48(4):325-335. doi:10.2519/jospt.2018.7931.

Effect assessment of “film coating and packaging” on the photo-stability of highly photo-labile antihypertensive products

PubMed Central

Mukharya, Amit; Patel, Paresh U; Chaudhary, Shivang

2013-01-01

Introduction: Lacidipine (LCDP) is chemically a “1, 4-dihydropyridine derivative” Ca+2 channel blocker used as an antihypertensive. Type and extent of packaging have a strong influence on the photo-stability of the 1,4-dihydropyridine derivatives. In standard, light protection of drug substance/drug product can be obtained either by use of an opaque additive in the formulation that competitively absorbs or reflects light reaching the sample and/or by blocking the access of light to the drug through external protection by packaging. Materials and Methods: External protection by covering tablets with an opaque film coating involving a light-reflecting inorganic pigment such as titanium dioxide and/or by using an opaque impermeable packaging material was an appropriate suitable option for establishing photo-stability. Thus, the main objective of the present study was to optimize the % level of film coating in LCDP core tablets, and selection of a final packaging material and its respective extent, that is, primary, secondary and/or tertiary packaging, for LCDP tablets. Results and Conclusion: The main objective (% level of film coating) was optimized by directly exposing core tablets, 1% w/w, 2% w/w and 3% w/w film-coated tablets, to a light source as per Option-2 of ICH Q1B and its comparative analysis at the end of light exposure testing. The other objective (extent of drug product packaging) was established successfully by assessing whether or not an acceptable change has occurred at the end of the light exposure testing of the LCDP film-coated tablets in a direct exposure study or a primary immediate pack and/or secondary marketing pack. PMID:24015379

Performance of alternative strategies for primary cervical cancer screening in sub-Saharan Africa: systematic review and meta-analysis of diagnostic test accuracy studies

PubMed Central

Combescure, Christophe; Fokom-Defo, Victoire; Tebeu, Pierre Marie; Vassilakos, Pierre; Kengne, André Pascal; Petignat, Patrick

2015-01-01

Objective To assess and compare the accuracy of visual inspection with acetic acid (VIA), visual inspection with Lugol’s iodine (VILI), and human papillomavirus (HPV) testing as alternative standalone methods for primary cervical cancer screening in sub-Saharan Africa. Design Systematic review and meta-analysis of diagnostic test accuracy studies. Data sources Systematic searches of multiple databases including Medline, Embase, and Scopus for studies published between January 1994 and June 2014. Review methods Inclusion criteria for studies were: alternative methods to cytology used as a standalone test for primary screening; study population not at particular risk of cervical cancer (excluding studies focusing on HIV positive women or women with gynaecological symptoms); women screened by nurses; reference test (colposcopy and directed biopsies) performed at least in women with positive screening results. Two reviewers independently screened studies for eligibility and extracted data for inclusion, and evaluated study quality using the quality assessment of diagnostic accuracy studies 2 (QUADAS-2) checklist. Primary outcomes were absolute accuracy measures (sensitivity and specificity) of screening tests to detect cervical intraepithelial neoplasia grade 2 or worse (CIN2+). Results 15 studies of moderate quality were included (n=61 381 for VIA, n=46 435 for VILI, n=11 322 for HPV testing). Prevalence of CIN2+ did not vary by screening test and ranged from 2.3% (95% confidence interval 1.5% to 3.3%) in VILI studies to 4.9% (2.7% to 7.8%) in HPV testing studies. Positivity rates of VILI, VIA, and HPV testing were 16.5% (9.8% to 24.7%), 16.8% (11.0% to 23.6%), and 25.8% (17.4% to 35.3%), respectively. Pooled sensitivity was higher for VILI (95.1%; 90.1% to 97.7%) than VIA (82.4%; 76.3% to 87.3%) in studies where the reference test was performed in all women (P<0.001). Pooled specificity of VILI and VIA were similar (87.2% (78.1% to 92.8%) v 87.4% (77.1% to 93.4%); P=0.85). Pooled sensitivity and specificity were similar for HPV testing versus VIA (both P≥0.23) and versus VILI (both P≥0.16). Accuracy of VIA and VILI increased with sample size and time period. Conclusions For primary screening of cervical cancer in sub-Saharan Africa, VILI is a simple and affordable alternative to cytology that demonstrates higher sensitivity than VIA. Implementation studies are needed to assess the effect of these screening strategies on the incidence and outcomes of cervical cancer in the region. PMID:26142020

Electronystagmography and audio potentials in space flight

NASA Technical Reports Server (NTRS)

Thornton, William E.; Biggers, W. P.; Pool, Sam L.; Thomas, W. G.; Thagard, Norman E.

1985-01-01

Beginning with the fourth flight of the Space Transport System (STS-4), objective measurements of inner ear function were conducted in near-zero G conditions in earth orbit. The problem of space motion sickness (SMS) was approached much like any disequilibrium problem encountered clinically. However, objective testing techniques had built-in limitations superimposed by the strict parameters inherent in each mission. An attempt was made to objectively characterize SMS, and to first ascertain whether the objective measurements indicated that this disorder was of peripheral or central origin. Electronystagmography and auditory brain stem response recordings were the primary investigative tools. One of the authors (W.E.T.) was a mission specialist on board the orbiter Challenger on the eighth shuttle mission (STS-8) and had the opportunity to make direct and personal observations regarding SMS, an opportunity which has added immeasurably to our understanding of this disorder. Except for two abnormal ENG records, which remain to be explained, the remaining ENG records and all the ABR records made in the weightless environment of space were normal.

Redesign and Evaluation of a Patient Assessment Course

PubMed Central

Sobieraj, Diana M.; McCaffrey, Desmond; Lee, Jennifer J.

2009-01-01

Objectives To redesign a patient assessment course using a structured instructional design process and evaluate student learning. Design Course coordinators collaborated with an instructional design and development expert to incorporate new pedagogical approaches (eg, Web-based self-tests), create new learning activities (eg, peer collaboration on worksheets, SOAP note writing), and develop grading rubrics. Assessment Formative and summative surveys were administered for student self-assessment and course evaluation. Seventy-six students (78%) completed the summative survey. The mean course grade was 91.8% ± 3.6%, with more than 75% of students reporting achievement of primary course learning objectives. All of the additional learning activities helped students meet the learning objectives with the exception of the written drug information response. Conclusion The use of a structured instructional design process to redesign a patient assessment course was successful in creating a curriculum that succeeded in teaching students the specified learning objectives. Other colleges and schools are encouraged to collaborate with an instructional design and development expert to improve the pharmacy curriculum. PMID:19960090

Quantifiers more or less quantify online: ERP evidence for partial incremental interpretation

PubMed Central

Urbach, Thomas P.; Kutas, Marta

2010-01-01

Event-related brain potentials were recorded during RSVP reading to test the hypothesis that quantifier expressions are incrementally interpreted fully and immediately. In sentences tapping general knowledge (Farmers grow crops/worms as their primary source of income), Experiment 1 found larger N400s for atypical (worms) than typical objects (crops). Experiment 2 crossed object typicality with non-logical subject-noun phrase quantifiers (most, few). Off-line plausibility ratings exhibited the crossover interaction predicted by full quantifier interpretation: Most farmers grow crops and Few farmers grow worms were rated more plausible than Most farmers grow worms and Few farmers grow crops. Object N400s, although modulated in the expected direction, did not reverse. Experiment 3 replicated these findings with adverbial quantifiers (Farmers often/rarely grow crops/worms). Interpretation of quantifier expressions thus is neither fully immediate nor fully delayed. Furthermore, object atypicality was associated with a frontal slow positivity in few-type/rarely quantifier contexts, suggesting systematic processing differences among quantifier types. PMID:20640044

Lightning protection technology for small general aviation composite material aircraft

NASA Technical Reports Server (NTRS)

Plumer, J. A.; Setzer, T. E.; Siddiqi, S.

1993-01-01

An on going NASA (Small Business Innovative Research) SBIR Phase II design and development program will produce the first lightning protected, fiberglass, General Aviation aircraft that is available as a kit. The results obtained so far in development testing of typical components of the aircraft kit, such as the wing and fuselage panels indicate that the lightning protection design methodology and materials chosen are capable of protecting such small composite airframes from lightning puncture and structural damage associated with severe threat lightning strikes. The primary objective of the program has been to develop a lightening protection design for full scale test airframe and verify its adequacy with full scale laboratory testing, thus enabling production and sale of owner-built, lightning-protected, Stoddard-Hamilton Aircraft, Inc. Glasair II airplanes. A second objective has been to provide lightning protection design guidelines for the General Aviation industry, and to enable these airplanes to meet lightening protection requirements for certification of small airplanes. This paper describes the protection design approaches and development testing results obtained thus far in the program, together with design methodology which can achieve the design goals listed above. The presentation of this paper will also include results of some of the full scale verification tests, which will have been completed by the time of this conference.

Results of aeroheating DFI and ET design-data test on a 0.0175-scale model 60-OTS conducted in the Von Karman Gas Dynamics Facility (VKF) 40" supersonic and the 50" hypersonic wind tunnels A and C

NASA Technical Reports Server (NTRS)

Marroquin, J.; Leef, C. R.

1985-01-01

The 0.0175-scale thin-skin thermocouple Model 60-OTS was tested in the von Karman Gas Facility 40-inch continuous flow supersonic tunnel A and the VKF Tunnel C. Testing was conducted at Mach numbers 2.25 to 4.0, and Reynolds numbers from 0.4 x 10 to the 6th power/ft to 6.6 x 10 to the 6th power/ft. Angle of attack range was from -5.0 to +5.0 degrees, and angle of sideslip range was from -6 to +6 degrees. The primary objective of this test was to provide a valid base for the external tank (ET) and solid rocket booster (SRB) heating prediction methodology for ascent flight by taking heating data at Development Flight Instrumentation (DFI) locations for flight conditions simulating STS-1 through -4. A second objective was to obtain additional aeroheating data to support potential reduction of the thermal protection system (TPS) on the ET. The third phase of the test was funded and conducted by NASA/MSFC for the purpose of establishing confidence in the data base from the lower temperature tunnel A.

National Positioning, Navigation, and Timing Architecture Study [Executive Summary

DOT National Transportation Integrated Search

2008-09-01

This primary objective of this study is to develop a comprehensive workflow to guide Oklahoma DOT to apply the LIDAR technology to landslide monitoring and risk assessment on Oklahoma highways. In addition to the primary objective, this study also ai...

Prospective validation of a lymphocyte infiltration prognostic test in stage III colon cancer patients treated with adjuvant FOLFOX.

PubMed

Emile, Jean-François; Julié, Catherine; Le Malicot, Karine; Lepage, Come; Tabernero, Josep; Mini, Enrico; Folprecht, Gunnar; Van Laethem, Jean-Luc; Dimet, Stéphanie; Boulagnon-Rombi, Camille; Allard, Marc-Antoine; Penault-Llorca, Frédérique; Bennouna, Jaafar; Laurent-Puig, Pierre; Taieb, Julien

2017-09-01

The prognostic value of lymphocyte infiltration (LI) of colorectal carcinoma (CC) has been demonstrated by several groups. However, no validated test is currently available for clinical practice. We previously described an automated and reproducible method for testing LI and aimed to validate it for clinical use. According to National Institutes of Health criteria, we designed a prospective validation of this biomarker in patients included in the PETACC8 phase III study. Primary objective was to compare percentage of patients alive and without recurrence at 2 years in patients with high versus low LI (#NCT02364024). Associations of LI with patient recurrence and survival were analysed, and multivariable models were adjusted for treatment and relevant factors. Automated testing of LI was performed on virtual slides without access to clinical data. Among the 1220 CC patients enrolled, LI was high, low and not evaluable in 241 (19.8%), 790 (64.8%) and 189 (15.5%), respectively. Primary objective was met with a 2-year recurrence rate of 14.4% versus 21.1% in patients with high and low LI, respectively (p = 0.02). Patients with high LI also had better disease free survival (DFS) and overall survival (OS). Tumour stage, grade, RAS status and BRAF status were with LI the only prognostic markers in multivariable analysis for OS. Subgroup analyses revealed that high LI had better DFS and OS in mismatch repair (MMR) proficient patients, and in patients without RAS mutation, but not in MMR deficient and RAS mutated patients. Although this is the first validation with high level of evidence (IIB) of the prognostic value of a LI test in colon cancers, it still needs to be confirmed in independent series of colon cancer patients. Copyright © 2017 Elsevier Ltd. All rights reserved.

Improving home-based providers' communication to primary care providers to enhance care coordination.

PubMed

Gum, Amber M; Dautovich, Natalie D; Greene, Jennifer; Hirsch, Anne; Schonfeld, Lawrence

2015-01-01

Health care system fragmentation is a pervasive problem. Research has not delineated concrete behavioral strategies to guide providers to communicate with personnel in other organizations to coordinate care. We addressed this gap within a particular context: home-based providers delivering depression care management (DCM) to older adults requiring coordination with primary care personnel. Our objective was to pilot test a communication protocol ('BRIDGE - BRinging Inter-Disciplinary Guidelines to Elders') in conjunction with DCM. In an open pilot trial (N = 7), home-based providers delivered DCM to participants. Following the BRIDGE protocol, home-based providers made scripted telephone calls and sent structured progress reports to personnel in participants' primary care practices with concise information and requests for assistance. Home-based providers documented visits with participants, contacts to and responses from primary care personnel. A research interviewer assessed participant outcomes [Symptom Checklist-20 (depressive symptoms), World Health Organization Disability Assessment Schedule-12, satisfaction] at baseline, three months, and six months. Over 12 months, home-based providers made 2.4 telephone calls and sent 6.3 faxes to other personnel, on average per participant. Primary care personnel responded to 18 of 22 requests (81.8%; 2 requests dropped, 2 ongoing), with at least one response per participant. Participants' depressive symptoms and disability improved significantly at both post-tests with large effect sizes (d ranged 0.73-2.3). Participants were satisfied. Using BRIDGE, home-based providers expended a small amount of effort to communicate with primary care personnel, who responded to almost all requests. Larger scale research is needed to confirm findings and potentially extend BRIDGE to other client problems, professions, and service sectors.

Using developmental research to design innovative knowledge translation technology for spinal cord injury in primary care: Actionable Nuggets™ on SkillScribe™

PubMed Central

Smith, Karen M.; Naumann, Danielle N.; McDiarmid Antony, Laura; McColl, Mary Ann; Aiken, Alice

2014-01-01

Context/Objective Actionable Nuggets™ for spinal cord injury (SCI) are a knowledge translation tool facilitating evidence-based primary care practice, originally developed in 2010 and refined in 2013. Evaluation results from these two phases of development have informed the design of SkillScribe™, an innovative electronic platform intended to offer reflective continuing medical education (CME) programming through mobile devices in order to support the key features of the Actionable Nuggets™ approach. This brief article describes the ongoing development of Actionable Nuggets™ for SCI on SkillScribe™ by: (1) summarizing the work to date on Actionable Nuggets™; (2) describing evaluation results of Actionable Nuggets™; (3) placing SkillScribe™ in the context of adult education. Design Developmental Research Design. Setting Canadian primary care. Participants Primary care physicians; specialist physicians. Interventions Twenty educational modules on SCI. Outcome measures Pre- and post-test knowledge survey, feedback and use statistics, impact assessment survey, qualitative analysis of evaluation data. Results In both hard copy and electronic form, physicians report that Actionable Nuggets™ are an acceptable and useful approach to providing CME for low-prevalence, high-impact conditions like SCI. The key elements of this tool are that they: offer evidence-based information in small, focused “nuggets”; position information where physicians most frequently seek it; offer information in a format that permits direct translation into action in primary care; allow time for reflection; attach practice tools; and offer CME credit. Conclusion Actionable Nuggets™ for SCI, delivered using a convenient and portable electronic medium, with time-released content and interactive testing has the potential to improve the primary care of patients with SCI. PMID:25229739

Development of the Primary Care Quality-Homeless (PCQ-H) Instrument: A Practical Survey of Patients' Experiences in Primary Care

PubMed Central

Kertesz, Stefan. G.; Pollio, David E.; Jones, Richard N.; Steward, Jocelyn; Stringfellow, Erin J.; Gordon, Adam J.; Johnson, Nancy K.; Kim, Theresa A.; Granstaff, Unita; Austin, Erika L.; Young, Alexander S.; Golden, Joya; Davis, Lori L.; Roth, David L.; Holt, Cheryl L.

2015-01-01

Background Homeless patients face unique challenges in obtaining primary care responsive to their needs and context. Patient experience questionnaires could permit assessment of patient-centered medical homes for this population, but standard instruments may not reflect homeless patients' priorities and concerns. Objectives This report describes (a) the content and psychometric properties of a new primary care questionnaire for homeless patients and (b) the methods utilized in its development. Methods Starting with quality-related constructs from the Institute of Medicine, we identified relevant themes by interviewing homeless patients and experts in their care. A multidisciplinary team drafted a preliminary set of 78 items. This was administered to homeless-experienced clients (n=563) across 3 VA facilities and 1 non-VA Health Care for the Homeless Program. Using Item Response Theory, we examined Test Information Function curves to eliminate less informative items and devise plausibly distinct subscales. Results The resulting 33-item instrument (Primary Care Quality-Homeless, PCQ-H) has four subscales: Patient-Clinician Relationship (15 items), Cooperation among Clinicians (3 items), Access/Coordination (11 items) and Homeless-Specific Needs (4 items). Evidence for divergent and convergent validity is provided. Test Information Function (TIF) graphs showed adequate informational value to permit inferences about groups for 3 subscales (Relationship, Cooperation and Access/Coordination). The 3-item Cooperation subscale had lower informational value (TIF<5) but had good internal consistency (alpha=0.75) and patients frequently reported problems in this aspect of care. Conclusions Systematic application of qualitative and quantitative methods supported the development of a brief patient-reported questionnaire focused on the primary care of homeless patients and offers guidance for future population-specific instrument development. PMID:25023918

Primary care providers’ experiences with and perceptions of personalized genomic medicine

PubMed Central

Carroll, June C.; Makuwaza, Tutsirai; Manca, Donna P.; Sopcak, Nicolette; Permaul, Joanne A.; O’Brien, Mary Ann; Heisey, Ruth; Eisenhauer, Elizabeth A.; Easley, Julie; Krzyzanowska, Monika K.; Miedema, Baukje; Pruthi, Sandhya; Sawka, Carol; Schneider, Nancy; Sussman, Jonathan; Urquhart, Robin; Versaevel, Catarina; Grunfeld, Eva

2016-01-01

Abstract Objective To assess primary care providers’ (PCPs’) experiences with, perceptions of, and desired role in personalized medicine, with a focus on cancer. Design Qualitative study involving focus groups. Setting Urban and rural interprofessional primary care team practices in Alberta and Ontario. Participants Fifty-one PCPs. Methods Semistructured focus groups were conducted and audiorecorded. Recordings were transcribed and analyzed using techniques informed by grounded theory including coding, interpretations of patterns in the data, and constant comparison. Main findings Five focus groups with the 51 participants were conducted; 2 took place in Alberta and 3 in Ontario. Primary care providers described limited experience with personalized medicine, citing breast cancer and prenatal care as main areas of involvement. They expressed concern over their lack of knowledge, in some circumstances relying on personal experiences to inform their attitudes and practice. Participants anticipated an inevitable role in personalized medicine primarily because patients seek and trust their advice; however, there was underlying concern about the magnitude of information and pace of discovery in this area, particularly in direct-to-consumer personal genomic testing. Increased knowledge, closer ties to genetics specialists, and relevant, reliable personalized medicine resources accessible at the point of care were reported as important for successful implementation of personalized medicine. Conclusion Primary care providers are prepared to discuss personalized medicine, but they require better resources. Models of care that support a more meaningful relationship between PCPs and genetics specialists should be pursued. Continuing education strategies need to address knowledge gaps including direct-to-consumer genetic testing, a relatively new area provoking PCP concern. Primary care providers should be mindful of using personal experiences to guide care. PMID:27737998

Analysis of the serum reproductive system related autoantibodies of infertility patients in Tianjin region of China

PubMed Central

Huo, Yan; Xu, Yanying; Wang, Jianmei; Wang, Fang; Liu, Yu; Zhang, Yujuan; Zhang, Bumei

2015-01-01

Object: Reproductive system related autoantibodies have been proposed to be associated with natural infertility. However, large scale systematic analysis of these of antibodies has not been conducted. The aim of this study is to analyze the positive rate of antisperm antibody (ASAb), anti-endometrium antibody (EMAb), anti-ovary antibody (AOAb), anti-zona pellucida antibody (AZP) and anticardiolipin antibody (ACA) in infertility patients in Tianjin region of China. Methods: 1305 male and 1711 female primary infertility patients and 1100 female secondary infertility patients were included in this study, as well as 627 healthy female controls. The above autoantibodies were tested and the positive rates in each group were calculated. Results: the positive rate of ASAb were significantly higher in primary infertility female than that in male, further analysis revealed that primary infertility population all exhibit significant higher positive rate of EMAb, AOAb, AZP and ACA compared with control group. Furthermore, the positive rates of all the antibodies in primary infertility female were significantly higher than those in secondary infertility female. Conclusions: Our study thus indicates that these autoantibodies might be associated with immunological related primary infertility and may have clinical significance in its diagnosis and treatment. PMID:26550366

Mixing geometric and radiometric features for change classification

NASA Astrophysics Data System (ADS)

Fournier, Alexandre; Descombes, Xavier; Zerubia, Josiane

2008-02-01

Most basic change detection algorithms use a pixel-based approach. Whereas such approach is quite well defined for monitoring important area changes (such as urban growth monitoring) in low resolution images, an object based approach seems more relevant when the change detection is specifically aimed toward targets (such as small buildings and vehicles). In this paper, we present an approach that mixes radiometric and geometric features to qualify the changed zones. The goal is to establish bounds (appearance, disappearance, substitution ...) between the detected changes and the underlying objects. We proceed by first clustering the change map (containing each pixel bitemporal radiosity) in different classes using the entropy-kmeans algorithm. Assuming that most man-made objects have a polygonal shape, a polygonal approximation algorithm is then used in order to characterize the resulting zone shapes. Hence allowing us to refine the primary rough classification, by integrating the polygon orientations in the state space. Tests are currently conducted on Quickbird data.

Adaptive strategies of remote systems operators exposed to perturbed camera-viewing conditions

NASA Technical Reports Server (NTRS)

Stuart, Mark A.; Manahan, Meera K.; Bierschwale, John M.; Sampaio, Carlos E.; Legendre, A. J.

1991-01-01

This report describes a preliminary investigation of the use of perturbed visual feedback during the performance of simulated space-based remote manipulation tasks. The primary objective of this NASA evaluation was to determine to what extent operators exhibit adaptive strategies which allow them to perform these specific types of remote manipulation tasks more efficiently while exposed to perturbed visual feedback. A secondary objective of this evaluation was to establish a set of preliminary guidelines for enhancing remote manipulation performance and reducing the adverse effects. These objectives were accomplished by studying the remote manipulator performance of test subjects exposed to various perturbed camera-viewing conditions while performing a simulated space-based remote manipulation task. Statistical analysis of performance and subjective data revealed that remote manipulation performance was adversely affected by the use of perturbed visual feedback and performance tended to improve with successive trials in most perturbed viewing conditions.

Bacterial profile in primary teeth with necrotic pulp and periapical lesions.

PubMed

da Silva, Léa Assed Bezerra; Nelson-Filho, Paulo; Faria, Gisele; de Souza-Gugelmin, Maria Cristina Monteiro; Ito, Izabel Yoko

2006-01-01

The objective of this study was to evaluate the bacterial profile in root canals of human primary teeth with necrotic pulp and periapical lesions using bacterial culture. A total of 20 primary teeth with necrotic pulp and radiographically visible radiolucent areas in the region of the bone furcation and/or the periapical region were selected. After crown access, 4 sterile absorbent paper points were introduced sequentially into the root canal for collection of material. After 30 s, the paper points were removed and placed in a test tube containing reduced transport fluid (RTF) and were sent for microbiological evaluation. Anaerobic microorganisms were found in 100% of the samples, black-pigmented bacilli in 30%, aerobic microorganisms in 60%, streptococci in 85%, gram-negative aerobic rods in 15% and staphylococci were not quantified. Mutans streptococci were found in 6 root canals (30%), 5 canals with Streptococcus mutans and 1 canal with Streptococcus mutans and Streptococcus sobrinus. It was concluded that in root canals of human primary teeth with necrotic pulp and periapical lesions, the infection is polymicrobial with predominance of anaerobic microorganisms.

Management commitments and primary care: another lesson from Costa Rica for the world?

PubMed

Soors, Werner; De Paepe, Pierre; Unger, Jean-Pierre

2014-01-01

Maintained dedication to primary care has fostered a public health delivery system with exceptional outcomes in Costa Rica. For more than a decade, management commitments have been part of Costa Rican health reform. We assessed the effect of the Costa Rican management commitments on access and quality of care and on compliance with their intended objectives. We constructed seven hypotheses on opinions of primary care providers. Through a mixed qualitative and quantitative approach, we tested these hypotheses and interpreted the research findings. Management commitments consume an excessive proportion of consultation time, inflate recordkeeping, reduce comprehensiveness in primary care consultations, and induce a disproportionate consumption of hospital emergency services. Their formulation relies on norms in need of optimization, their control on unreliable sources. They also affect professionalism. In Costa Rica, management commitments negatively affect access and quality of care and pose a threat to the public service delivery system. The failures of this pay-for-performance-like initiative in an otherwise well-performing health system cast doubts on the appropriateness of pay-for-performance for health systems strengthening in less advanced environments.

Component testing of a ground based gas turbine steam cooled rich-burn primary zone combustor for emissions control of nitrogeneous fuels

NASA Technical Reports Server (NTRS)

Schultz, D. F.

1986-01-01

This effort summarizes the work performed on a steam cooled, rich-burn primary zone, variable geometry combustor designed for combustion of nitrogeneous fuels such as heavy oils or synthetic crude oils. The steam cooling was employed to determine its feasibility and assess its usefulness as part of a ground based gas turbine bottoming cycle. Variable combustor geometry was employed to demonstrate its ability to control primary and secondary zone equivalence ratios and overall pressure drop. Both concepts proved to be highly successful in achieving their desired objectives. The steam cooling reduced peak liner temperatures to less than 800 K. This low temperature offers the potential of both long life and reduced use of strategic materials for liner fabrication. These degrees of variable geometry were successfully employed to control air flow distribution within the combustor. A variable blade angle axial flow air swirler was used to control primary zone air flow, while the secondary and tertiary zone air flows were controlled by rotating bands which regulated air flow to the secondary zone quench holes and the dilutions holes respectively.

The STEP mission - Satellite test of the equivalence principle

NASA Technical Reports Server (NTRS)

Atzei, A.; Swanson, P.; Anselmi, A.

1992-01-01

The STEP experiment is a joint ESA/NASA mission candidate for selection as the next medium science project in the ESA scientific program. ESA and NASA have undertaken a joint feasibility study of STEP. The principles of STEP and details of the mission are presented and the mission and spacecraft are described. The primary objective of STEP is to measure differences in the rate of fall of test masses of different compositions to one part in 10 exp 17 of the total gravitational acceleration, a factor of 10 exp 8 improvement in sensitivity over previous experiments. STEP constitutes a comparison of gravitational and inertial mass or a test of the weak equivalence principle (WEP). A test of WEP that is six orders of magnitude more accurate than previous tests will reveal whether the underlying structure of the universe is filled with undiscovered small forces, necessitating a fundamental change in our theories of matter on all scales.

High Current ESD Test of Advanced Triple Junction Solar Array Coupon

NASA Technical Reports Server (NTRS)

Wright, Kenneth H., Jr.; Schneider, Todd A.; Vaughn, Jason A.; Hoang, Bao; Wong, Frankie

2015-01-01

A test was conducted on an Advanced Triple Junction (ATJ) coupon that was part of a risk reduction effort in the development of a high-powered solar array design by SSL. The ATJ coupon was a small, 4-cell, two-string configuration that has served as the basic test coupon design used in previous SSL environmental aging campaigns. The coupon has many attributes of the flight design; e.g., substrate structure with graphite face sheets, integrated by-pass diodes, cell interconnects, RTV grout, wire routing, etc. The objective of the present test was to evaluate the performance of the coupon after being subjected to induced electrostatic discharge testing at two string voltages (100 V, 150 V) and four array current (1.65 A, 2.0 A, 2.475 A, and 3.3 A). An ESD test circuit, unique to SSL solar array design, was built that simulates the effect of missing cells and strings in a full solar panel with special primary arc flashover circuitry. A total of 73 primary arcs were obtained that included 7 temporary sustained arcs (TSA) events. The durations of the TSAs ranged from 50 micros to 2.9 ms. All TSAs occurred at a string voltage of 150 V. Post-test Large Area Pulsed Solar Simulator (LAPSS), Dark I-V, and By-Pass Diode tests showed that no degradation occurred due to the TSA events. In addition, the post-test insulation resistance measured was > 50 G-ohms between cells and substrate. These test results indicate a robust design for application to a high-current, high-power mission application.

High Current ESD Test of Advanced Triple Junction Solar Array Coupon

NASA Technical Reports Server (NTRS)

Wright, K. H.; Schneider, T. A.; Vaughn, J. A.; Hoang, B.; Wong, F.

2014-01-01

A test was conducted on an Advanced Triple Junction (ATJ) coupon that was part of a risk reduction effort in the development of a high-powered solar array design by SSL. The ATJ coupon was a small, 4-cell, two-string configuration that has served as the basic test coupon design used in previous SSL environmental aging campaigns. The coupon has many attributes of the flight design; e.g., substrate structure with graphite face sheets, integrated by-pass diodes, cell interconnects, RTV grout, wire routing, etc. The objective of the present test was to evaluate the performance of the coupon after being subjected to induced electrostatic discharge testing at two string voltages (100 V, 150 V) and four array current (1.65 A, 2.0 A, 2.475 A, and 3.3 A). An ESD test circuit, unique to SSL solar array design, was built that simulates the effect of missing cells and strings in a full solar panel with special primary arc flashover circuitry. A total of 73 primary arcs were obtained that included 7 temporary sustained arcs (TSA) events. The durations of the TSAs ranged from 50 µs to 2.9 ms. All TSAs occurred at a string voltage of 150 V. Post-test Large Area Pulsed Solar Simulator (LAPSS), Dark I-V, and By-Pass Diode tests showed that no degradation occurred due to the TSA events. In addition, the post-test insulation resistance measured was > 50 G-ohms between cells and substrate. These test results indicate a robust design for application to a high-current, high-power mission application.

High Current ESD Test of Advanced Triple Junction Solar Array Coupon

NASA Technical Reports Server (NTRS)

Wright, Kenneth H., Jr.; Schneider, Todd A.; Vaughn, Jason A.; Hoang, Bao; Wong, Frankie

2014-01-01

Testing was conducted on an Advanced Triple Junction (ATJ) coupon that was part of a risk reduction effort in the development of a high-powered solar array design by Space Systems/Loral, LLC (SSL). The ATJ coupon was a small, 4-cell, two-string configuration that has served as the basic test coupon design used in previous SSL environmental aging campaigns. The coupon has many attributes of the flight design; e.g., substrate structure with graphite face sheets, integrated by-pass diodes, cell interconnects, RTV grout, wire routing, etc. The objective of the present test was to evaluate the performance of the coupon after being subjected to induced electrostatic discharge (ESD) testing at two string voltages (100 V, 150 V) and four array currents (1.65 A, 2.0 A, 2.475 A, and 3.3 A). An ESD test circuit, unique to SSL solar array design, was built that simulates the effect of missing cells and strings in a full solar panel with special primary arc flashover circuitry. A total of 73 primary arcs were obtained that included 7 temporary sustained arcs (TSA) events. The durations of the TSAs ranged from 50 micro-seconds to 2.75 milli-seconds. All TSAs occurred at a string voltage of 150 V. Post-test Large Area Pulsed Solar Simulator (LAPSS), Dark I-V, and By-Pass Diode tests showed that no degradation occurred due to the TSA events. In addition, the post-test insulation resistance measured was > 50 G-ohms between cells and substrate. These test results indicate a robust design for application to a high-current, high-power mission.

A knowledge-based system design/information tool for aircraft flight control systems

NASA Technical Reports Server (NTRS)

Mackall, Dale A.; Allen, James G.

1991-01-01

Research aircraft have become increasingly dependent on advanced electronic control systems to accomplish program goals. These aircraft are integrating multiple disciplines to improve performance and satisfy research objective. This integration is being accomplished through electronic control systems. Systems design methods and information management have become essential to program success. The primary objective of the system design/information tool for aircraft flight control is to help transfer flight control system design knowledge to the flight test community. By providing all of the design information and covering multiple disciplines in a structured, graphical manner, flight control systems can more easily be understood by the test engineers. This will provide the engineers with the information needed to thoroughly ground test the system and thereby reduce the likelihood of serious design errors surfacing in flight. The secondary object is to apply structured design techniques to all of the design domains. By using the techniques in the top level system design down through the detailed hardware and software designs, it is hoped that fewer design anomalies will result. The flight test experiences are reviewed of three highly complex, integrated aircraft programs: the X-29 forward swept wing; the advanced fighter technology integration (AFTI) F-16; and the highly maneuverable aircraft technology (HiMAT) program. Significant operating technologies, and the design errors which cause them, is examined to help identify what functions a system design/informatin tool should provide to assist designers in avoiding errors.

The Effects of Terrain and Navigation on Human Extravehicular Activity Walkback Performance on the Moon

NASA Technical Reports Server (NTRS)

Norcross, Jason; Stroud, Leah C.; Schaffner, Grant; Glass, Brian J.; Lee, Pascal C.; Jones, Jeff A.; Gernhardt, Michael L.

2008-01-01

Results of the EVA Walkback Test showed that 6 male astronauts were able to ambulate 10 km on a level treadmill while wearing a prototype EVA suit in simulated lunar gravity. However, the effects of lunar terrain, topography, and real-time navigation on ambulation performance are unknown. Primary objective: To characterize the effect of lunar-like terrain and navigation on VO2 and distance traveled during an unsuited 10 km (straight-line distance) ambulatory return in earth gravity.

UAVSAR: Airborne L-band Radar for Repeat Pass Interferometry

NASA Technical Reports Server (NTRS)

Moes, Timothy R.

2009-01-01

The primary objectives of the UAVSAR Project were to: a) develop a miniaturized polarimetric L-band synthetic aperture radar (SAR) for use on an unmanned aerial vehicle (UAV) or piloted vehicle. b) develop the associated processing algorithms for repeat-pass differential interferometric measurements using a single antenna. c) conduct measurements of geophysical interest, particularly changes of rapidly deforming surfaces such as volcanoes or earthquakes. Two complete systems were developed. Operational Science Missions began on February 18, 2009 ... concurrent development and testing of the radar system continues.

Learning-Theoretic Foundations of Linguistic Universals

DTIC Science & Technology

1974-11-01

constructed experimental situations in which such predictions are tested. Rathär we are concerned with the more primary task of constructing firm and...for a unicorn . (22) may be true or false even if there is no such thing as a unicorn . There is a second reading, of course, in which a unicont must...the direct object of the verb is looking for may be either the intension of a unicorn , which we may represent here informally as a unicorn1, or the

A full-scale wind tunnel investigation of a helicopter bearingless main rotor. [Ames 40 by 80 Wind Tunnel

NASA Technical Reports Server (NTRS)

Warmbrodt, W.; Mccloud, J. L., II

1981-01-01

A helicopter bearingless main rotor was tested. Areas of investigation included aeroelastic stability, aerodynamic performance, and rotor loads as a function of collective pitch setting, RPM, airspeed and shaft angle. The rotor/support system was tested with the wind tunnel balance dampers installed and, subsequently, removed. Modifications to the rotor hub were tested. These included a reduction in the rotor control system stiffness and increased flexbeam structural damping. The primary objective of the test was to determine aeroelastic stability of the fundamental flexbeam/blade chordwise bending mode. The rotor was stable for all conditions. Damping of the rotor chordwise bending mode increases with increased collective pitch angle at constant operating conditions. No significant decrease in rotor damping occured due to frequency coalescence between the blade chordwise fundamental bending mode and the support system.

Alloy 690 qualification: Corrosion under prototypic heat flux and temperature conditions. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baum, A.J.

1995-05-01

The objective of this program was to perform qualification tests of industrial heats of thermally treated alloy 690 steam generator tubing under heat transfer conditions. Primary emphasis was focused on testing of alternate tube to tubesheet expansion processes. In addition, a background report was written to document the evolution of the alloy 690 process specification and the supporting qualification testing. While the testing was able to produce some localized corrosion of alloy 690 in the tube to tubesheet joint transition regions under highly alkaline conditions, the corrosion rates were between two and three orders of magnitude lower than the comparablemore » rates in mill annealed alloy 600 tubing. The corrosion morphology was a combination of intergranular and general corrosion, rather than the stress corrosion cracking typically found in mill annealed alloy 600 tubing.« less

Solar Sail Models and Test Measurements Correspondence for Validation Requirements Definition

NASA Technical Reports Server (NTRS)

Ewing, Anthony; Adams, Charles

2004-01-01

Solar sails are being developed as a mission-enabling technology in support of future NASA science missions. Current efforts have advanced solar sail technology sufficient to justify a flight validation program. A primary objective of this activity is to test and validate solar sail models that are currently under development so that they may be used with confidence in future science mission development (e.g., scalable to larger sails). Both system and model validation requirements must be defined early in the program to guide design cycles and to ensure that relevant and sufficient test data will be obtained to conduct model validation to the level required. A process of model identification, model input/output documentation, model sensitivity analyses, and test measurement correspondence is required so that decisions can be made to satisfy validation requirements within program constraints.

Dynamic response of NASA Rotor Test Apparatus and Sikorsky S-76 hub mounted in the 80- by 120-Foot Wind Tunnel

NASA Technical Reports Server (NTRS)

Peterson, Randall L.; Hoque, Muhammed S.

1994-01-01

A shake test was conducted in the 80- by 120-Foot Wind Tunnel at NASA Ames Research Center, using the NASA Ames Rotor Test Apparatus (RTA) and the Sikorsky S-76 rotor hub. The primary objective of this shake test was to determine the modal properties of the RTA, the S-76 rotor hub, and the model support system installed in the wind tunnel. Random excitation was applied at the rotor hub, and vibration responses were measured using accelerometers mounted at various critical locations on the model and the model support system. Transfer functions were computed using the load cell data and the accelerometer responses. The transfer function data were used to compute the system modal parameters with the aid of modal analysis software.

The point prevalence of otitis media with effusion among primary school children in Western Sicily.

PubMed

Martines, Francesco; Bentivegna, Daniela; Di Piazza, Fabiola; Martinciglio, Gioacchino; Sciacca, Vincenzo; Martines, Enrico

2010-05-01

The objective of this study is to identify the prevalence of otitis media with effusion (OME) in primary school children and to value the possible predisposing factors focusing on relationship between allergy and OME in Western Sicily. 2,097 children attending primary school were screened from September 2006 to June 2007 in Sciacca. Children underwent pneumatic otoscopy, skin tests, tympanogram and acoustic reflex tests. Audiogram was performed if the child had a type B or a type C tympanogram. The criteria for diagnosis of OME were: documented persistent middle ear effusion by otoscopic examination for a minimum of 3 months, presence of B or C tympanogram, absence of ipsilateral acoustic reflex and a conductive hearing loss greater than 25 dB at any one of the frequencies from 250 Hz to 4 kHz. OME was identified in 143 children, in 61 of whom OME was unilateral and in 82 of whom it was bilateral. The overall prevalence of OME was 6.8%, with a maximum prevalence of 12.9% between 5 and 6 years of age. By increasing age, the prevalence of OME decreased. Also, we found a higher prevalence rate of OME in children with positive skin tests (62.9%) than those with negative skin tests (37.1%). The present study evidences the high social impact of OME, whose prevalence is directly correlated to age and atopy. Moreover, our finding supports the literature data that climatic and environmental factors may also have a role in the occurrence of OME.

PubMed Central

2013-01-01

Summary Introduction and objectives. For children, maintenance of personal hygiene helps to improve the quality of life and longevity. This is of particular importance in a slum community with compromised living situation. This study was undertaken to find out the knowledge and practice of personal hygiene among the primary school children living in a slum area, to identify any misconception among them regarding the maintenance of personal hygiene, to find out their morbidity pattern, and also to elicit the relationship between practice of personal hygiene among the children and the literacy status of their mother. Methods. A cross-sectional observational study was conducted among 104 primary school children of a primary school situated in the slum area of Chetla, Kolkata, India with the help of a predesigned, pre-tested and structured questionnaire. Data were analyzed statistically by simple proportions and tests of significance. Results. It was found that the female students were more knowledgeable than the male students regarding the maintenance of personal hygiene. There was a wide gap between practice and knowledge of personal hygiene among the primary school children living in the slum area. Even, misconceptions do exist on certain indicators of personal hygiene among the students. Statistically significant association was observed between practices of personal hygiene among the primary school children and the literacy status of their mother. Discussion and conclusions. Future of a society depends considerably on the health of its children. The parents and the school teachers, as constructive shapers of children's health behaviors, should play a responsible role in early education of children on personal hygiene. PMID:24783893

Recovery Act: Pilot Integrated Cellulosic Biorefinery Operations to Fuel Ethanol

DOE Office of Scientific and Technical Information (OSTI.GOV)

Javers, Jeremy

DOE EE002875 Technical Report Public Release. The objective was to leverage ICM’s pre-existing corn to ethanol pilot plant to build and to commission a fully functional pilot integrated cellulosic biorefinery. ICM’s Integrated Biorefinery (IBR) project was designed to achieve four major objectives. These primary goals were achieved during the performance period from December 2009 – August 2015. The design and construction phase took place from December 2009 until August 2011, with an increase in budget of nearly 4 million dollars. This increased cost was offset by operational changes, so the amount spent for the overall project increased by less thanmore » $500,000. There were three 1,000-hour performance test conducted, which produced cellulosic feedstock.« less

A Unified Satellite-Observation Polar Stratospheric Cloud (PSC) Database for Long-Term Climate-Change Studies

NASA Technical Reports Server (NTRS)

Fromm, Michael; Pitts, Michael; Alfred, Jerome

2000-01-01

This report summarizes the project team's activity and accomplishments during the period 12 February, 1999 - 12 February, 2000. The primary objective of this project was to create and test a generic algorithm for detecting polar stratospheric clouds (PSC), an algorithm that would permit creation of a unified, long term PSC database from a variety of solar occultation instruments that measure aerosol extinction near 1000 nm The second objective was to make a database of PSC observations and certain relevant related datasets. In this report we describe the algorithm, the data we are making available, and user access options. The remainder of this document provides the details of the algorithm and the database offering.

Feasibility and Preliminary Efficacy of the Fit4Fun Intervention for Improving Physical Fitness in a Sample of Primary School Children: A Pilot Study

ERIC Educational Resources Information Center

Eather, Narelle; Morgan, Philip J.; Lubans, David R.

2013-01-01

Objective: The primary objective of this study was to evaluate the feasibility and preliminary efficacy of a school-based physical fitness intervention (Fit4Fun) on the physical fitness and physical activity (PA) levels of primary school children. Methods: A group-randomized controlled trial with a 3-month wait-list control group was conducted in…

[Characteristics of allergic conjunctivitis with positive skin prick test].

PubMed

Yang, S; Jiang, Y; Jin, Y M; Zhang, J Y; Li, Y

2017-09-11

Objective: To observe the clinical characteristics of allergic conjunctivitis, and the correlations with skin prick test results. Methods: A retrospective study. Forty patients with positive skin prick test result were included. Patients underwent an ophthalmologic examination to identify their primary presenting signs and symptoms. The allergy types were divided into 5 groups. All dates were analyzed for the dependence, normality and homogeneity of variance. Chi-square test, Mann-Whitney U test, Kruskal-Wallis H test and Spearman correlation analysis were performed accordingly. Results: Among 40 patients, 18(45.0%) had a clinical diagnosis of seasonal allergic conjunctivitis, 14(35.0%) had perennial allergic conjunctivitis, 5(12.5%) had vernal keratoconjunctivitis, and 2(5.0%) had atopic keratoconjunctivits, and 1(2.5%) had giant papillary conjunctivitis. There was no significant difference in the number of symptoms and signs score among different types of allergic conjunctivitis, the score of itching and hyperemia had a positive relationship with the number of positive allergens ( r =0.74, P< 0.05. r =0.96, P< 0.05). The primary symptoms and signs are itching and hyperemia; dust and pollens are the most common allergens. The more positive result of the test of the allergen, the more symptoms and signs encountered in terms of severity. Conclusion: Seasonal allergic conjunctivitis was the most prevalent disorder, the most important clinical characteristics of allergic conjunctivitis are itching and conjunctival congestion, the main allergens are dust and pollens, patients may be sensitive to multiple allergens. (Chin J Ophthalmol, 2017, 53: 689-693) .

Randomized, Blinded Pilot Testing of Nonconventional Stimulation Patterns and Shapes in Parkinson's Disease and Essential Tremor: Evidence for Further Evaluating Narrow and Biphasic Pulses

PubMed Central

Akbar, Umer; Raike, Robert S.; Hack, Nawaz; Hess, Christopher W.; Skinner, Jared; Martinez‐Ramirez, Daniel; DeJesus, Sol

2016-01-01

Objectives Evidence suggests that nonconventional programming may improve deep brain stimulation (DBS) therapy for movement disorders. The primary objective was to assess feasibility of testing the tolerability of several nonconventional settings in Parkinson's disease (PD) and essential tremor (ET) subjects in a single office visit. Secondary objectives were to explore for potential efficacy signals and to assess the energy demand on the implantable pulse‐generators (IPGs). Materials and Methods A custom firmware (FW) application was developed and acutely uploaded to the IPGs of eight PD and three ET subjects, allowing delivery of several nonconventional DBS settings, including narrow pulse widths, square biphasic pulses, and irregular pulse patterns. Standard clinical rating scales and several objective measures were used to compare motor outcomes with sham, clinically‐optimal and nonconventional settings. Blinded and randomized testing was conducted in a traditional office setting. Results Overall, the nonconventional settings were well tolerated. Under these conditions it was also possible to detect clinically‐relevant differences in DBS responses using clinical rating scales but not objective measures. Compared to the clinically‐optimal settings, some nonconventional settings appeared to offer similar benefit (e.g., narrow pulse widths) and others lesser benefit. Moreover, the results suggest that square biphasic pulses may deliver greater benefit. No unexpected IPG efficiency disadvantages were associated with delivering nonconventional settings. Conclusions It is feasible to acutely screen nonconventional DBS settings using controlled study designs in traditional office settings. Simple IPG FW upgrades may provide more DBS programming options for optimizing therapy. Potential advantages of narrow and biphasic pulses deserve follow up. PMID:27000764

History of Hubble Space Telescope (HST)

NASA Image and Video Library

1986-01-01

This image illustrates the Hubble Space Telescope's (HST's) Optical Telescope Assembly (OTA). One of the three major elements of the HST, the OTA consists of two mirrors (a primary mirror and a secondary mirror), support trusses, and the focal plane structure. The mirrors collect and focus light from selected celestial objects and are housed near the center of the telescope. The primary mirror captures light from objects in space and focuses it toward the secondary mirror. The secondary mirror redirects the light to a focal plane where the Scientific Instruments are located. The primary mirror is 94.5 inches (2.4 meters) in diameter and the secondary mirror is 12.2 inches (0.3 meters) in diameter. The purpose of the HST, the most complex and sensitive optical telescope ever made, is to study the cosmos from a low-Earth Orbit. By placing the telescope in space, astronomers are able to collect data that is free of the Earth's atmosphere. The HST detects objects 25 times fainter than the dimmest objects seen from the Earth and provides astronomers with an observable universe 250 times larger than visible from ground-based telescopes, perhaps as far away as 14 billion light-years. The HST views galaxies, stars, planets, comets, possibly other solar systems, and even unusual phenomena such as quasars, with 10 times the clarity of ground-based telescopes. The spacecraft is 42.5 feet (13 meters) long and weighs 25,000 pounds (11,600 kilograms). The HST was deployed from the Space Shuttle Discovery (STS-31 mission) into Earth orbit in April 1990. The Marshall Space Flight Center had responsibility for design, development, and construction of the HST. The Perkin-Elmer Corporation, in Danbury, Cornecticut, developed the optical system and guidance sensors. The Lockheed Missile and Space Company of Sunnyvale, California produced the protective outer shroud and spacecraft systems, and assembled and tested the finished telescope.

The eyes reveal uncertainty about object distinctions in semantic variant primary progressive aphasia.

PubMed

Faria, Andreia V; Race, David; Kim, Kevin; Hillis, Argye E

2018-06-01

At least three distinct variants of primary progressive aphasia (PPA) have been described, but they are difficult to distinguish early in the course, when individuals experience primarily anomia. People with svPPA are often the hardest to care for, because they have impaired comprehension of words and objects and often have negative changes in comportment. We sought to identify an early marker of semantic variant primary progressive aphasia (svPPA) and to enhance the understanding of the semantic deficit in svPPA. We hypothesized that the pattern of eye tracking in a word picture matching task can differentiate svPPA from other variants and can predict which participants with unclassifiable PPA will progress to svPPA. We tested 19 individuals with PPA on a word picture matching task with eye tracking. We found that individuals with svPPA were less accurate than other variants when the foils were semantic coordinates (horse-cow) or schematically related (horse-saddle), but not when they were thematically related (saw-horse) or unrelated. Moreover, even in the condition in which they were highly accurate (unrelated foils) they looked much more often to the foils and for longer, than other variants or controls. Unclassifiable PPA participants who eventually developed svPPA showed the same pattern. This abnormal pattern was associated with atrophy in bilateral temporal poles. Copyright © 2018. Published by Elsevier Ltd.

A scheme for the uniform mapping and monitoring of earth resources and environmental complexes using ERTS-1 imagery

NASA Technical Reports Server (NTRS)

Poulton, C. E. (Principal Investigator); Welch, R. I.

1973-01-01

There are no author-identified significant results in this report. Progress on plans for the development and testing of a practical procedure and system for the uniform mapping and monitoring of natural ecosystems and environmental complexes from space-acquired imagery is discussed. With primary emphasis on ERTS-1 imagery, but supported by appropriate aircraft photography as necessary, the objectives are to accomplish the following: (1) Develop and test in a few selected sites and areas of the western United States a standard format for an ecological and land use legend for making natural resource inventories on a simulated global basis. (2) Based on these same limited geographic areas, identify the potentialities and limitations of the legend concept for the recognition and annotation of ecological analogs and environmental complexes. An additional objective is to determine the optimum combination of space photography, aerial photography, ground data, human data analysis, and automatic data analysis for estimating crop yield in the rice growing areas of California and Louisiana.

Stability and lifetime testing of photomultiplier detectors for the Earth observing system SOLSTICE program

NASA Astrophysics Data System (ADS)

Hadler, Joshua A.; van de Kop, Toni; Drake, Virginia A.; McClintock, William E.; Murphy, John; Rodgers, Paul

1998-10-01

The primary objective of the Earth Observing System (EOS) Solar Stellar Irradiance Comparison Experiment (SOLSTICE) is to accurately measure the absolute value of the solar UV irradiance at the top of the earth's atmosphere for a minimum mission lifetime of 5 years. To meet this objective, SOLSTICE employs a unique design to determine changes in instrument performance by routinely observing a series of early-type stars and comparing the irradiances directly with the solar value. Although the comparison techniques allows us to track instrument performance, the success of the SOLSTICE experiment depends upon photomultiplier detectors which have graceful degradation properties. Therefore, we have established a laboratory program to evaluate the characteristics of photomultiplier tubes which are exposed to long term fluxes similar to those we expected to encounter in flight. Three types of Hamamatsu photomultiplier tubes were tested as candidates for use in the EOS-SOLSTICE project. The results of these studies: pulse height distribution; quantum efficiency; surface maps,; and lifetime analysis are presented in this paper.

Dynamic test results for the CASES ground experiment

NASA Technical Reports Server (NTRS)

Bukley, Angelia P.; Patterson, Alan F.; Jones, Victoria L.

1993-01-01

The Controls, Astrophysics, and Structures Experiment in Space (CASES) Ground Test Facility (GTF) has been developed at Marshall Space Flight Center (MSFC) to provide a facility for the investigation of Controls/Structures Interaction (CSI) phenomena, to support ground testing of a potential shuttle-based CASES flight experiment, and to perform limited boom deployment and retraction dynamics studies. The primary objectives of the ground experiment are to investigate CSI on a test article representative of a Large Space Structure (LSS); provide a platform for Guest Investigators (GI's) to conduct CSI studies; to test and evaluate LSS control methodologies, system identification (ID) techniques, failure mode analysis; and to compare ground test predictions and flight results. The proposed CASES flight experiment consists of a 32 meter deployable/retractable boom at the end of which is an occulting plate. The control objective of the experiment is to maintain alignment of the tip plate (occulter) with a detector located at the base of the boom in the orbiter bay. The tip plate is pointed towards a star, the sun, or the galactic center to collect high-energy X-rays emitted by these sources. The tip plate, boom, and detector comprise a Fourier telescope. The occulting holes in the tip plate are approximately one millimeter in diameter making the alignment requirements quite stringent. Control authority is provided by bidirectional linear thrusters located at the boom tip and Angular Momentum Exchange Devices (AMED's) located at mid-boom and at the tip. The experiment embodies a number of CSI control problems including vibration suppression, pointing a long flexible structure, and disturbance rejection. The CASES GTF is representative of the proposed flight experiment with identical control objectives.

10 CFR 4.13 - Employment practices.

Code of Federal Regulations, 2013 CFR

2013-01-01

... practices. (a) Where a primary objective of the Federal financial assistance to a program to which this... compensation, and use of facilities), including programs where a primary objective of the Federal financial... commencement or continuation of their education or training, or (2) to provide work experience which...

Fast Appearance Modeling for Automatic Primary Video Object Segmentation.

PubMed

Yang, Jiong; Price, Brian; Shen, Xiaohui; Lin, Zhe; Yuan, Junsong

2016-02-01

Automatic segmentation of the primary object in a video clip is a challenging problem as there is no prior knowledge of the primary object. Most existing techniques thus adapt an iterative approach for foreground and background appearance modeling, i.e., fix the appearance model while optimizing the segmentation and fix the segmentation while optimizing the appearance model. However, these approaches may rely on good initialization and can be easily trapped in local optimal. In addition, they are usually time consuming for analyzing videos. To address these limitations, we propose a novel and efficient appearance modeling technique for automatic primary video object segmentation in the Markov random field (MRF) framework. It embeds the appearance constraint as auxiliary nodes and edges in the MRF structure, and can optimize both the segmentation and appearance model parameters simultaneously in one graph cut. The extensive experimental evaluations validate the superiority of the proposed approach over the state-of-the-art methods, in both efficiency and effectiveness.

Effects of substrate salinity on early seedling survival and growth of Scirpus robustus Pursh and Spartina alterniflora Loisel.

PubMed

Lewis, Michael A; Weber, David E

2002-02-01

Rooted aquatic plants are being used increasingly to test the toxicity of sediments. However, effects of naturally occurring substrate constituents on most potential test species are not well understood even though their effects could affect the test results. The objective of this study was to determine the effect of substrate salinity (NaCl) on early seedling survival and growth of the emergent macrophytes, Scirpus robustus Pursh and Spartina alterniflora Loisel. Results of four 21- and 28-day toxicity tests, conducted in an artificial sediment, indicated interspecific differences in NaCl sensitivity when based on changes in shoot, root and whole plant dry-weight biomass. Concentrations of 7.8 g NaCl/l and 19.2 g NaCl/l first reduced early seedling biomass of S. robustus and S. alterniflora (P<0.05), respectively, when compared to plants grown in sediment containing no measurable salinity. Seedling survival was not affected at average concentrations of 17.5 g NaCl/l or less for S. robustus and 22.3 g NaCl/l or less for S. alterniflora. The results indicate that substrate salinity is an important consideration in the selection of test species for laboratory phytotoxicity tests conducted with estuarine sediments, particularly if determination of chronic toxicity attributable to anthropogenic contamination is the primary objective.

Propfan Test Assessment (PTA)

NASA Technical Reports Server (NTRS)

Little, B. H.; Poland, D. T.; Bartel, H. W.; Withers, C. C.; Brown, P. C.

1989-01-01

The objectives of the Propfan Test Assessment (PTA) Program were to validate in flight the structural integrity of large-scale propfan blades and to measure noise characteristics of the propfan in both near and far fields. All program objectives were met or exceeded, on schedule and under budget. A Gulfstream Aerospace Corporation GII aircraft was modified to provide a testbed for the 2.74m (9 ft) diameter Hamilton Standard SR-7 propfan which was driven by a 4475 kw (600 shp) turboshaft engine mounted on the left-hand wing of the aircraft. Flight research tests were performed for 20 combinations of speed and altitude within a flight envelope that extended to Mach numbers of 0.85 and altitudes of 12,192m (40,000 ft). Propfan blade stress, near-field noise on aircraft surfaces, and cabin noise were recorded. Primary variables were propfan power and tip speed, and the nacelle tilt angle. Extensive low altitude far-field noise tests were made to measure flyover and sideline noise and the lateral attenuation of noise. In coopertion with the FAA, tests were also made of flyover noise for the aircraft at 6100m (20,000 ft) and 10,668m (35,000 ft). A final series of tests were flown to evaluate an advanced cabin wall noise treatment that was produced under a separate program by NASA-Langley Research Center.

Cluster Development Test 2: An Assessment of a Failed Test

NASA Technical Reports Server (NTRS)

Machin, Ricardo A.; Evans, Carol T.

2009-01-01

On 31 July 2008 the National Aeronautics and Space Administration Crew Exploration Vehicle Parachute Assembly System team conducted the final planned cluster test of the first generation parachute recovery system design. The two primary test objectives were to demonstrate the operation of the complete parachute system deployed from a full scale capsule simulator and to demonstrate the test technique of separating the capsule simulator from the Low Velocity Air Drop pallet used to extract the test article from a United States Air Force C-17 aircraft. The capsule simulator was the Parachute Test Vehicle with an accurate heat shield outer mold line and forward bay compartment of the Crew Exploration Vehicle Command Module. The Parachute Test Vehicle separated cleanly from the pallet following extraction, but failed to reach test conditions resulting in the failure of the test and the loss of the test assets. No personnel were injured. This paper will discuss the design of the test and the findings of the team that investigated the test, including a discussion of what were determined to be the root causes of the failure.

A phase II trial with anti-Lewis-Y monoclonal antibody (hu3S193) for the treatment of platinum resistant/refractory ovarian, fallopian tube and primary peritoneal carcinoma.

PubMed

Smaletz, Oren; Diz, Maria D P E; do Carmo, Claudio C; Sabbaga, Jorge; Cunha-Junior, Geraldo F; Azevedo, Sergio J; Maluf, Fernando C; Barrios, Carlos H; Costa, Ronaldo L; Fontana, Ana G; Madrigal, Vivian; Wainstein, Alberto J; Yeda, Fernanda P; Alves, Venâncio A; Moro, Ana M; Blasbalg, Roberto; Scott, Andrew M; Hoffman, Eric W

2015-08-01

The primary objective was to evaluate the clinical efficacy of hu3S193, a humanized monoclonal antibody against the Lewis-Y antigen, in patients with platinum resistant/refractory ovarian, fallopian tube and primary peritoneal carcinoma. Secondary objectives were safety and pharmacokinetics. In addition, we sought to determine the potential interaction of clinical benefit and patient characteristics. This two-stage, multicenter, single arm, phase II trial enrolled eligible patients to receive hu3S193 weekly at a dose of 20mg/m(2) intravenously for 8 weeks (1 cycle) to a maximum of 3 cycles. Efficacy was measured as clinical benefit rate (objective response or stable disease for at least 24 weeks). 26 of 31 patients were eligible for efficacy analysis. No complete/partial responses were observed. Six patients had stable disease for 24+weeks [clinical benefit rate 23% (95% CI=9.77%-46.71%)]. Median PFS was 8.4 weeks (95% CI=6.0 to 16.1). Median PFS differed between patients with no ascites and no visceral disease and patients with ascites and/or visceral disease [16.1 vs. 8.1 weeks (p=0.0058)]. The most commonly reported treatment-related adverse events were fatigue (19.3%) and nausea (16.2%). Allergic reactions occurred in 6 patients (5 with Grade 1/2; 1 with Grade 3). Hu3S193 lacked sufficient activity in the first stage of the study to open enrollment to the second stage. However, based on the longer PFS in patients with no ascites and no visceral disease, consolidation strategies in platinum sensitive disease are currently being tested. Copyright © 2015 Elsevier Inc. All rights reserved.

Precision measurement and modeling of superconducting magnetic bearings for the satellite test of the equivalence principle

NASA Astrophysics Data System (ADS)

Sapilewski, Glen Alan

The Satellite Test of the Equivalence Principle (STEP) is a modern version of Galileo's experiment of dropping two objects from the leaning tower of Pisa. The Equivalence Principle states that all objects fall with the same acceleration, independent of their composition. The primary scientific objective of STEP is to measure a possible violation of the Equivalence Principle one million times better than the best ground based tests. This extraordinary sensitivity is made possible by using cryogenic differential accelerometers in the space environment. Critical to the STEP experiment is a sound fundamental understanding of the behavior of the superconducting magnetic linear bearings used in the accelerometers. We have developed a theoretical bearing model and a precision measuring system with which to validate the model. The accelerometers contain two concentric hollow cylindrical test masses, of different materials, each levitated and constrained to axial motion by a superconducting magnetic bearing. Ensuring that the bearings satisfy the stringent mission specifications requires developing new testing apparatus and methods. The bearing is tested using an actively-controlled table which tips it relative to gravity. This balances the magnetic forces from the bearing against a component of gravity. The magnetic force profile of the bearing can be mapped by measuring the tilt necessary to position the test mass at various locations. An operational bearing has been built and is being used to verify the theoretical levitation models. The experimental results obtained from the bearing test apparatus were inconsistent with the previous models used for STEP bearings. This led to the development of a new bearing model that includes the influence of surface current variations in the bearing wires and the effect of the superconducting transformer. The new model, which has been experimentally verified, significantly improves the prediction of levitation current, accurately estimates the relationship between tilting and translational modes, and predicts the dependence of radial mode frequencies on the bearing current. In addition, we developed a new model for the forces produced by trapped magnetic fluxons, a potential source of imperfections in the bearing. This model estimates the forces between magnetic fluxons trapped in separate superconducting objects.

Understanding type 2 diabetes mellitus screening practices among primary care physicians: a qualitative chart-stimulated recall study.

PubMed

Hafez, Dina; Nelson, Daniel B; Martin, Evan G; Cohen, Alicia J; Northway, Rebecca; Kullgren, Jeffrey T

2017-04-04

Early diagnosis and treatment of prediabetes and type 2 diabetes mellitus (T2DM) can prevent future health problems, yet many individuals with these conditions are undiagnosed. This could be due, in part, to primary care physicians' (PCP) screening practices, about which little is known. The objectives of this study were to identify factors that influence PCPs' decisions to screen patients for T2DM and to characterize their interpretation and communication of screening test results to patients. We conducted semi-structured chart-stimulated recall interviews with 20 University of Michigan Health System (UMHS) primary care physicians. PCPs were asked about their recent decisions to screen or not screen 134 purposively sampled non-diabetic patients who met American Diabetes Association criteria for screening for T2DM. Interviews were audio-recorded, transcribed, and analyzed using qualitative directed content analysis. Data on patient demographic characteristics and comorbidities were abstracted from the electronic health record. The most common reasons PCPs gave for not screening 63 patients for T2DM were knowledge of a previously normal screening test (49%) and a visit for reasons other than a health maintenance examination (48%). The most common reasons PCPs gave for screening 71 patients for T2DM were knowledge of a previously abnormal screening test (49%), and patients' weight (42%) and age (38%). PCPs correctly interpreted 89% of screening test results and communicated 95% of test results to patients. Among 24 patients found to have prediabetes, PCPs usually (58%) recommended weight loss and increased physical activity but never recommended participation in a Diabetes Prevention Program or use of metformin. Previous screening test results, visit types, and patients' weight and age influenced PCPs' decisions to screen for T2DM. When patients were screened, test results were generally correctly interpreted and consistently communicated. Recommendations to patients with prediabetes could better reflect evidence-based strategies to prevent T2DM.

Design of the primary pre-TRMM and TRMM ground truth site

NASA Technical Reports Server (NTRS)

Garstang, Michael

1988-01-01

The primary objective of the Tropical Rain Measuring Mission (TRMM) were to: integrate the rain gage measurements with radar measurements of rainfall using the KSFC/Patrick digitized radar and associated rainfall network; delineate the major rain bearing systems over Florida using the Weather Service reported radar/rainfall distributions; combine the integrated measurements with the delineated rain bearing systems; use the results of the combined measurements and delineated rain bearing systems to represent patterns of rainfall which actually exist and contribute significantly to the rainfall to test sampling strategies and based on the results of these analyses decide upon the ground truth network; and complete the design begun in Phase 1 of a multi-scale (space and time) surface observing precipitation network centered upon KSFC. Work accomplished and in progress is discussed.

Initial stability of press-fit acetabular components under rotational forces.

PubMed

Fehring, Keith A; Owen, John R; Kurdin, Anton A; Wayne, Jennifer S; Jiranek, William A

2014-05-01

The primary goal of this study was to determine the initial press-fit stability in acetabular components without screw fixation. Mechanical testing was performed with the implantation of press-fit acetabular components in cadaveric specimens. No significant difference was found in load to failure testing between 1 and 2 mm of under-reaming. However, there was significant variability in bending forces required to create 150 μm of micromotion ranging from 49.3 N to 214.4 N. This study shows that cups implanted in a press-fit fashion, which are felt to be clinically stable, have high degrees of variability in resisting load and may be at risk for loosening. There is a need for more objective intra-operative techniques to test cup stability. © 2014.

Material-specific difficulties in episodic memory tasks in mild traumatic brain injury.

PubMed

Tsirka, Vassiliki; Simos, Panagiotis; Vakis, Antonios; Vourkas, Michael; Arzoglou, Vasileios; Syrmos, Nikolaos; Stavropoulos, Stavros; Micheloyannis, Sifis

2010-03-01

The study examines acute, material-specific secondary memory performance in 26 patients with mild traumatic brain injury (MTBI) and 26 healthy controls, matched on demographic variables and indexes of crystallized intelligence. Neuropsychological tests were used to evaluate primary and secondary memory, executive functions, and verbal fluency. Participants were also tested on episodic memory tasks involving words, pseudowords, pictures of common objects, and abstract kaleidoscopic images. Patients showed reduced performance on episodic memory measures, and on tasks associated with visuospatial processing and executive function (Trail Making Test part B, semantic fluency). Significant differences between groups were also noted for correct rejections and response bias on the kaleidoscope task. MTBI patients' reduced performance on memory tasks for complex, abstract stimuli can be attributed to a dysfunction in the strategic component of memory process.

A Theory-Grounded Measure of Adolescents’ Response to a Media Literacy Intervention

PubMed Central

Greene, Kathryn; Yanovitzky, Itzhak; Carpenter, Amanda; Banerjee, Smita C.; Magsamen-Conrad, Kate; Hecht, Michael L.; Elek, Elvira

2016-01-01

Media literacy interventions offer promising avenues for the prevention of risky health behaviors among children and adolescents, but current literature remains largely equivocal about their efficacy. The primary objective of this study was to develop and test theoretically-grounded measures of audiences’ degree of engagement with the content of media literacy programs based on the recognition that engagement (and not participation per se) can better explain and predict individual variations in the effects of these programs. We tested the validity and reliability of a measure of engagement with two different samples of 10th grade high school students who participated in a pilot and actual test of a brief media literacy curriculum. Four message evaluation factors (involvement, perceived novelty, critical thinking, personal reflection) emerged and demonstrate acceptable reliability. PMID:28042522

Phase 2 program on ground test of refanned JT8D turbofan engines and nacelles for the 727 airplane. Volume 3: Ground tests

NASA Technical Reports Server (NTRS)

1975-01-01

The NASA Refan Program included full-scale performance and noise ground tests of both a current production (JT8D-15) and a refanned (JT8D-115) engine. A description of the two ground tests including detailed propulsion, noise, and structural test results is presented. The primary objectives of the total test program were comparison of JT8D-15 and JT8D-115 overall propulsion system performance and noise characteristics and determination of incremental component noise levels. Other objectives of the test program included: (1) determination of acoustic treatment effectiveness; (2) measurement of internal sound pressure levels; (3) measurement of inlet and exhaust hardware performance; (4) determination of center-engine surge margin; and (5) evaluation of certain structural characteristics associated with the 727 refan center-engine inlet duct and JT8D refan engine exhaust system. The JT8D-15 and -115 tests were conducted during September 1974 and January to March 1975, respectively. Analyses of the test data indicated that the JT8D-115, as compared to the JT8D-15, demonstrates a 12.5 percent to 13.2 percent reduction in static specific fuel consumption, and a reduction of 6 to 7 PNdB in a weighted average value of static tone corrected perceived noise level. Separated into noise components, a significant reduction was shown for the inlet fan, aft fan, exhaust duct flow, turbine, and jet noises. However, core noise was increased. Photographs of test stands and test equipment are shown.

Testing for Statistical Discrimination by Race/Ethnicity in Panel Data for Depression Treatment in Primary Care

PubMed Central

McGuire, Thomas G; Ayanian, John Z; Ford, Daniel E; Henke, Rachel E M; Rost, Kathryn M; Zaslavsky, Alan M

2008-01-01

Objective To test for discrimination by race/ethnicity arising from clinical uncertainty in treatment for depression, also known as “statistical discrimination.” Data Sources We used survey data from 1,321 African-American, Hispanic, and white adults identified with depression in primary care. Surveys were administered every six months for two years in the Quality Improvement for Depression (QID) studies. Study Design To examine whether and how change in depression severity affects change in treatment intensity by race/ethnicity, we used multivariate cross-sectional and change models that difference out unobserved time-invariant patient characteristics potentially correlated with race/ethnicity. Data Collection/Extraction Methods Treatment intensity was operationalized as expenditures on drugs, primary care, and specialty services, weighted by national prices from the Medical Expenditure Panel Survey. Patient race/ethnicity was collected at baseline by self-report. Principal Findings Change in depression severity is less associated with change in treatment intensity in minority patients than in whites, consistent with the hypothesis of statistical discrimination. The differential effect by racial/ethnic group was accounted for by use of mental health specialists. Conclusions Enhanced physician–patient communication and use of standardized depression instruments may reduce statistical discrimination arising from clinical uncertainty and be useful in reducing racial/ethnic inequities in depression treatment. PMID:18370966

Screening for childhood strabismus by primary care physicians.

PubMed Central

Weinstock, V. M.; Weinstock, D. J.; Kraft, S. P.

1998-01-01

OBJECTIVE: To review the clinical classification of strabismus, to describe the timing and method of strabismus screening examinations, and to discuss the principles of treatment. QUALITY OF EVIDENCE: Current literature (1983 to 1995) was searched via MEDLINE using the MeSH headings strabismus, ocular motility disorders, and amblyopia. Articles were selected based on their date of publication, clinical relevance, and availability. Preference was given to more recent articles, articles with large numbers of subjects, and well-designed cohort studies. Official recommendations from academic groups were analyzed. Descriptions of clinical tests and their illustrations are based on classic texts. MAIN FINDINGS: Primary care physicians should screen all low-risk children. High-risk children (low birth weight, family history of strabismus, congenital ocular abnormality, or systemic conditions with vision-threatening ocular manifestations) should be referred to an ophthalmologist for screening. Screening should be performed in the neonatal period, at 6 months, and at 3 years (Grade A recommendation), as well as at 5 to 6 years (Grade B recommendation). Screening examination includes inspection, examining visual acuity, determining pupillary reactions, checking ocular alignment, testing eye movements, and ophthalmoscopy. CONCLUSIONS: Primary care physicians are essential to early detection of strabismus and amblyopia. Early detection can help minimize visual dysfunction, allow for normal development of binocular vision and depth perception, and prevent psychosocial dysfunction. PMID:9512837