Design Principles for Nickel/Hydrogen Cells and Batteries

NASA Technical Reports Server (NTRS)

Thaller, Lawrence H.; Manzo, Michelle A.; Gonzalez-Sanabria, Olga D.

1987-01-01

Individual-pressure-vessel (IPV) nickel/hydrogen cells and bipolar batteries developed for use as energy-storage subsystems for satelite applications. Design principles applied draw upon extensive background in separator technology, alkaline-fuel-cell technology and several alkaline-cell technology areas. Principals are rather straightforward applications of capillary-force formalisms, coupled with slowly developing data base resulting from careful post-test analyses. Based on preconceived assumptions relative to how devices work and how to be designed so they display longer cycle lives at deep discharge.

Sensors, Volume 1, Fundamentals and General Aspects

NASA Astrophysics Data System (ADS)

Grandke, Thomas; Ko, Wen H.

1996-12-01

'Sensors' is the first self-contained series to deal with the whole area of sensors. It describes general aspects, technical and physical fundamentals, construction, function, applications and developments of the various types of sensors. This volume deals with the fundamentals and common principles of sensors and covers the wide areas of principles, technologies, signal processing, and applications. Contents include: Sensor Fundamentals, e.g. Sensor Parameters, Modeling, Design and Packaging; Basic Sensor Technologies, e.g. Thin and Thick Films, Integrated Magnetic Sensors, Optical Fibres and Intergrated Optics, Ceramics and Oxides; Sensor Interfaces, e.g. Signal Processing, Multisensor Signal Processing, Smart Sensors, Interface Systems; Sensor Applications, e.g. Automotive: On-board Sensors, Traffic Surveillance and Control, Home Appliances, Environmental Monitoring, etc. This volume is an indispensable reference work and text book for both specialits and newcomers, researchers and developers.

Faraday's Principle and Air Travel in the Introductory Labs

ERIC Educational Resources Information Center

Abdul-Razzaq, Wathiq; Thakur, Saikat Chakraborty

2017-01-01

We all know that we must improve the quality of teaching in science at all levels. Not only physicists but also many students from other areas of study take the introductory physics courses in college. Physics introductory laboratories (labs) can be one of the best tools to help these students understand applications of scientific principles that…

Parenting: Does Research Support Biblical Principles: A Review of the Literature.

ERIC Educational Resources Information Center

Ganahl, Andrea Drew

This critical review examines 16 empirical studies applicable to 4 areas of parenting: (1) Nurturance; (2) Parenting Style; (3) Parents as role-models; and (4) Parenting in regard to individual differences in children. The studies were examined in the context of how each one supported Biblical principles. Each study was critiqued in terms of…

Design principles for nickel hydrogen cells and batteries

NASA Technical Reports Server (NTRS)

Thaller, L. H.

1985-01-01

Nickel hydrogen cells, and more recently, bipolar batteries have been built by a variety of organizations. The design principles that have been used by the technology group at the Lewis Research Center draw upon their extensive background in separator technology, alkaline fuel cell technology, and several alkaline cell technology areas. These design principles have been incorporated into both the more contemporary individual pressure vessel (IPV) designs that were pioneered by other groups, as well as the more recent bipolar battery designs using active cooling that are being developed at LeRC and their contractors. These principles are rather straightforward applications of capillary force formalisms, coupled with the slowly developing data base resulting from careful post test analyses. The objective of this overall effort is directed towards the low Earth orbit (LEO) application where the cycle life requirements are much more severe than the geosynchronous orbit (GEO) application. Nickel hydrogen cells have already been successfully flown in an increasing number of GEO missions.

From academic to applied: Operationalising resilience in river systems

NASA Astrophysics Data System (ADS)

Parsons, Melissa; Thoms, Martin C.

2018-03-01

The concept of resilience acknowledges the ability of societies to live and develop with dynamic environments. Given the recognition of the need to prepare for anticipated and unanticipated shocks, applications of resilience are increasing as the guiding principle of public policy and programs in areas such as disaster management, urban planning, natural resource management, and climate change adaptation. River science is an area in which the adoption of resilience is increasing, leading to the proposition that resilience may become a guiding principle of river policy and programs. Debate about the role of resilience in rivers is part of the scientific method, but disciplinary disunity about the ways to approach resilience application in policy and programs may leave river science out of the policy process. We propose six elements that need to be considered in the design and implementation of resilience-based river policy and programs: rivers as social-ecological systems; the science-policy interface; principles, capacities, and characteristics of resilience; cogeneration of knowledge; adaptive management; and the state of the science of resilience.

Energy Conversion and Storage Program

NASA Astrophysics Data System (ADS)

Cairns, E. J.

1993-06-01

This report is the 1992 annual progress report for the Energy Conversion and Storage Program, a part of the Energy and Environment Division of the Lawrence Berkeley Laboratory. Work described falls into three broad areas: electrochemistry; chemical applications; and materials applications. The Energy Conversion and Storage Program applies principles of chemistry and materials science to solve problems in several areas: (1) production of new synthetic fuels, (2) development of high-performance rechargeable batteries and fuel cells, (3) development of advanced thermochemical processes for energy conversion, (4) characterization of complex chemical processes and chemical species, and (5) study and application of novel materials for energy conversion and transmission. Projects focus on transport-process principles, chemical kinetics, thermodynamics, separation processes, organic and physical chemistry, novel materials, and advanced methods of analysis. Electrochemistry research aims to develop advanced power systems for electric vehicle and stationary energy storage applications. Chemical applications research includes topics such as separations, catalysis, fuels, and chemical analyses. Included in this program area are projects to develop improved, energy-efficient methods for processing product and waste streams from synfuel plants, coal gasifiers, and biomass conversion processes. Materials applications research includes evaluation of the properties of advanced materials, as well as development of novel preparation techniques. For example, techniques such as sputtering, laser ablation, and poised laser deposition are being used to produce high-temperature superconducting films.

The Demand for Water Transportation: Application of Discriminant Analysis to Commodities Shipped by Barge and Competing Modes in Ohio River and Arkansas River Areas.

DTIC Science & Technology

1980-08-01

extended to include influence of time in transit, perishability, and uncertainty in market 7Alfred Marshall, Principles of Economics , 9th Edition (McMillan...the Maritime Administration, U.S. Department of Commerce, Washington, D.C. (1974). Marshall, Alfred. Principles of Economics . 9th Edition. :.[cMillian

Iowa Commercial Pesticide Applicator Manual, Category 5: Aquatic Pest Control. CS-17.

ERIC Educational Resources Information Center

Jennings, Vivan M.; Ryan, Stephen O.

This manual provides information needed to meet specific standards for certification as a pesticide applicator. The text is concerned with the control of aquatic weeds in a variety of water use situations, i.e. static water, limited-flow impoundments and moving water. Also discussed are the principles of limited area application such as surface or…

CityGuideTour Toruń - tourist application using augmented reality

NASA Astrophysics Data System (ADS)

Węgrzyn, Magdalena; Mościcka, Albina

2017-12-01

The aim of the article is to show the possibilities of augmented reality in the fi eld of geodesy and cartography. It discusses the concept of augmented reality, its origins and development, as well as areas of the existing applications. The practical functioning of augmented reality in the area of geodesy and cartography is presented on the example of an application developed for the tourist city of Toruń, created with the use of CityGuideTour software. The principles of developing an application and the way it operates are also discussed. As a result, a fully operational bilingual application is available free of charge on the Web.

Multigrid techniques for unstructured meshes

NASA Technical Reports Server (NTRS)

Mavriplis, D. J.

1995-01-01

An overview of current multigrid techniques for unstructured meshes is given. The basic principles of the multigrid approach are first outlined. Application of these principles to unstructured mesh problems is then described, illustrating various different approaches, and giving examples of practical applications. Advanced multigrid topics, such as the use of algebraic multigrid methods, and the combination of multigrid techniques with adaptive meshing strategies are dealt with in subsequent sections. These represent current areas of research, and the unresolved issues are discussed. The presentation is organized in an educational manner, for readers familiar with computational fluid dynamics, wishing to learn more about current unstructured mesh techniques.

Functional magnetic resonance imaging.

PubMed

Buchbinder, Bradley R

2016-01-01

Functional magnetic resonance imaging (fMRI) maps the spatiotemporal distribution of neural activity in the brain under varying cognitive conditions. Since its inception in 1991, blood oxygen level-dependent (BOLD) fMRI has rapidly become a vital methodology in basic and applied neuroscience research. In the clinical realm, it has become an established tool for presurgical functional brain mapping. This chapter has three principal aims. First, we review key physiologic, biophysical, and methodologic principles that underlie BOLD fMRI, regardless of its particular area of application. These principles inform a nuanced interpretation of the BOLD fMRI signal, along with its neurophysiologic significance and pitfalls. Second, we illustrate the clinical application of task-based fMRI to presurgical motor, language, and memory mapping in patients with lesions near eloquent brain areas. Integration of BOLD fMRI and diffusion tensor white-matter tractography provides a road map for presurgical planning and intraoperative navigation that helps to maximize the extent of lesion resection while minimizing the risk of postoperative neurologic deficits. Finally, we highlight several basic principles of resting-state fMRI and its emerging translational clinical applications. Resting-state fMRI represents an important paradigm shift, focusing attention on functional connectivity within intrinsic cognitive networks. © 2016 Elsevier B.V. All rights reserved.

Research and application of self - propagating welding technology

NASA Astrophysics Data System (ADS)

Ma, Yunhe; Li, Zhizun; Wang, Jianjiang; Sun, Liming

2018-04-01

Self-propagating welding is an important application area of self-propagating high-temperature synthesis technology (SHS technology), suitable for special environment and special materials welding. This paper briefly introduces the principle of self - propagating welding and its technical characteristics, and briefly summarizes the current research and application of SHS welding around three aspects of thin film welding, welding of refractory welding and emergency welding of battlefield.

Electronic circuits for communications systems: A compilation

NASA Technical Reports Server (NTRS)

1972-01-01

The compilation of electronic circuits for communications systems is divided into thirteen basic categories, each representing an area of circuit design and application. The compilation items are moderately complex and, as such, would appeal to the applications engineer. However, the rationale for the selection criteria was tailored so that the circuits would reflect fundamental design principles and applications, with an additional requirement for simplicity whenever possible.

Agent-based modeling: Methods and techniques for simulating human systems

PubMed Central

Bonabeau, Eric

2002-01-01

Agent-based modeling is a powerful simulation modeling technique that has seen a number of applications in the last few years, including applications to real-world business problems. After the basic principles of agent-based simulation are briefly introduced, its four areas of application are discussed by using real-world applications: flow simulation, organizational simulation, market simulation, and diffusion simulation. For each category, one or several business applications are described and analyzed. PMID:12011407

Anti-Mechanized Defense: A Computerized Simulation for Squad Leader Training.

DTIC Science & Technology

1983-09-01

applicability of cybernetic principles is easily transformed to meet the needs of this research. Specifi- cally, the basic principle governing management...and as in other areas this is better meas- ured in actual field conditions. COMMAND AND CONTROL (S2A.2) Control of Organic Fi repower In general...AD-AI34 962 UNCLASSIFIED ANTI-MECHANIZED DEFENSE: A COMPUTERIZED SQUAD LEADER TRAINING(U) AIR FORCE INST WRIGHT-PATTERSON AFB OH SCHOOL OF SYST

Concept of information technology of monitoring and decision-making support

NASA Astrophysics Data System (ADS)

Kovalenko, Aleksandr S.; Tymchyk, Sergey V.; Kostyshyn, Sergey V.; Zlepko, Sergey M.; Wójcik, Waldemar; Kalizhanova, Aliya; Burlibay, Aron; Kozbekova, Ainur

2017-08-01

Presented concept of information technology monitoring and decision support to determine the health of students. The preconditions of a concept formulated its goal and purpose. Subject area concepts proposed to consider a set of problems, grouped into 8 categories, which in turn necessitates the application when creating technology basic principles from the principles of "first head" and "systems approach" to the principles of "interoperability" and "system integration ". The content of the information providing IT, its position in the segment of single information space, stages of creation. To evaluate the efficiency of the IT system developed proposed criteria.

Green extraction of natural products: concept and principles.

PubMed

Chemat, Farid; Vian, Maryline Abert; Cravotto, Giancarlo

2012-01-01

The design of green and sustainable extraction methods of natural products is currently a hot research topic in the multidisciplinary area of applied chemistry, biology and technology. Herein we aimed to introduce the six principles of green-extraction, describing a multifaceted strategy to apply this concept at research and industrial level. The mainstay of this working protocol are new and innovative technologies, process intensification, agro-solvents and energy saving. The concept, principles and examples of green extraction here discussed, offer an updated glimpse of the huge technological effort that is being made and the diverse applications that are being developed.

Globalizing rehabilitation psychology: Application of foundational principles to global health and rehabilitation challenges.

PubMed

Bentley, Jacob A; Bruyère, Susanne M; LeBlanc, Jeanne; MacLachlan, Malcolm

2016-02-01

This article reviewed foundational principles in rehabilitation psychology and explored their application to global health imperatives as outlined in the World Report on Disability (World Health Organization & World Bank, 2011). Historical theories and perspectives are used to assist with conceptual formulation as applied to emerging international rehabilitation psychology topics. According to the World Report on Disability (World Health Organization & World Bank, 2011), there are approximately 1 billion individuals living with some form of disability globally. An estimated 80% of persons with disabilities live in low- to middle-income countries (WHO, 2006). The primary messages and recommendations of the World Report on Disability have been previously summarized as it relates to potential opportunities for contribution within the field of rehabilitation psychology (MacLachlan & Mannan, 2014). Yet, undeniable barriers remain to realizing the full potential for contributions in low- to middle-income country settings. A vision for engaging in international capacity building and public health efforts is needed within the field of rehabilitation psychology. Foundational rehabilitation psychology principles have application to the service of individuals with disabilities in areas of the world facing complex socioeconomic and sociopolitical challenges. Foundational principles of person-environment interaction, importance of social context, and need for involvement of persons with disabilities can provide guidance to the field as it relates to global health and rehabilitation efforts. The authors illustrate the application of rehabilitation psychology foundational principles through case examples and description of ongoing work, and link foundational principles to discreet domains of intervention going forward. (c) 2016 APA, all rights reserved).

Improving animal research facility operations through the application of lean principles.

PubMed

Khan, Nabeel; Umrysh, Brian M

2008-06-01

Animal research is a vital component of US research and well-functioning animal research facilities are critical both to the research itself and to the housing and feeding of the animals. The Office of Animal Care (OAC) at Seattle Children's Hospital Research Institute realized it had to improve the efficiency and safety of its animal research facility (ARF) to prepare for expansion and to advance the Institute's mission. The main areas for improvement concerned excessive turnaround time to process animal housing and feeding equipment; the movement and flow of equipment and inventory; and personnel safety. To address these problems, management held two process improvement workshops to educate employees about lean principles. In this article we discuss the application of these principles and corresponding methods to advance Children's Research Institute's mission of preventing, treating, and eliminating childhood diseases.

Principles of continuous quality improvement applied to intravenous therapy.

PubMed

Dunavin, M K; Lane, C; Parker, P E

1994-01-01

Documentation of the application of the principles of continuous quality improvement (CQI) to the health care setting is crucial for understanding the transition from traditional management models to CQI models. A CQI project was designed and implemented by the IV Therapy Department at Lawrence Memorial Hospital to test the application of these principles to intravenous therapy and as a learning tool for the entire organization. Through a prototype inventory project, significant savings in cost and time were demonstrated using check sheets, flow diagrams, control charts, and other statistical tools, as well as using the Plan-Do-Check-Act cycle. As a result, a primary goal, increased time for direct patient care, was achieved. Eight hours per week in nursing time was saved, relationships between two work areas were improved, and $6,000 in personnel costs, storage space, and inventory were saved.

CE-TOF/MS: fundamental concepts, instrumental considerations and applications.

PubMed

Staub, Aline; Schappler, Julie; Rudaz, Serge; Veuthey, Jean-Luc

2009-05-01

This review discusses the fundamental principles of TOF analyzers and covers the great progress that has been made in this area in recent years (i.e. orthogonal acceleration, reflectron). This paper also gives an overview of applications performed by CE coupled to TOF/MS detection. The main domains of interest include the analysis of biomolecules and natural compounds.

Biosensor technology: recent advances in threat agent detection and medicine.

PubMed

Kirsch, Jeffrey; Siltanen, Christian; Zhou, Qing; Revzin, Alexander; Simonian, Aleksandr

2013-11-21

Biosensors are of great significance because of their capability to resolve a potentially large number of analytical problems and challenges in very diverse areas such as defense, homeland security, agriculture and food safety, environmental monitoring, medicine, pharmacology, industry, etc. The expanding role of biosensing in society and a real-world environment has led to an exponential growth of the R&D efforts around the world. The world market for biosensor devices, according to Global Industry Analysts, Inc., is expected to reach $12 billion by 2015. Such expedient growth is driven by several factors including medical and health problems, such as a growing population with a high risk of diabetes and obesity, and the rising incidence of chronic diseases such as heart disease, stroke, cancer, chronic respiratory diseases, tuberculosis, etc.; significant problems with environmental monitoring; and of course serious challenges in security and military applications and agriculture/food safety. A review paper in the biosensor technology area may be structured based on (i) the principles of detection, such as the type of transducer platform, bioanalytical principles (affinity or kinetic), and biorecognition elements origin/properties (i.e. antibodies, enzymes, cells, aptamers, etc.), and (ii) the application area. This review follows the latter strategy and focuses on the applications. This allows discussion on how different sensing strategies are brought to bear on the same problem and highlights advantages/disadvantages of these sensing strategies. Given the broad range of biosensor related applications, several particularly relevant areas of application were selected for review: biological threat agents, chemical threat agents, and medicine.

Budget Anthropology: A Unit Sampler.

ERIC Educational Resources Information Center

Fraker, G. Alan

Creative and inexpensive teaching suggestions for high school anthropology courses are presented. They are chosen specifically for programs which cannot afford expensive curriculum materials. All activities demonstrate the application of universal anthropological principles to the American society. Seven areas which reflect the general functions…

The Implementation of Organizational Design Principles Throughout the San Mateo County Emergency Services Joint Powers Agreement and its Ability to Increase Applicability, Relevance, and Effectiveness

DTIC Science & Technology

2011-12-01

District Colma Fire Protection District East Palo Alto Sanitary District (San Mateo) Granada Sanitary District (San Mateo) Los Trancos County Water ... agricultural , livestock, industrial, cultural, or other fairs or exhibitions shall be deemed to have common power with respect to any such fair or...concept of operation. These principles remain consistent in all areas of emergency management. The Public Entity Risk Institute’s Characteristics

Application of the WFD cost proportionality principle to diffuse pollution mitigation: a case study for Scottish Lochs.

PubMed

Vinten, A J A; Martin-Ortega, J; Glenk, K; Booth, P; Balana, B B; MacLeod, M; Lago, M; Moran, D; Jones, M

2012-04-30

The Water Framework Directive (WFD) aims to deliver good ecological status (GES) for Europe's waters. It prescribes the use of economic principles, such as derogation from GES on grounds of disproportionate costs of mitigation. This paper proposes an application of the proportionality principle to mitigation of phosphorus (P) pollution of 544 Scottish lochs at national and local water body scales. P loading estimates were derived from a national diffuse pollution screening tool. For 293 of these lochs (31% of the loch area), GES already occurred. Mitigation cost-effectiveness was assessed using combined mitigation cost curves for managed grassland, rough grazing, arable land, sewage and septic tank sources. These provided sufficient mitigation (92% of national P load) for GES to be achieved on another 31% of loch area at annualised cost of £2.09 m/y. Mitigation of the residual P loading preventing other lochs achieving GES was considered by using a "mop-up" cost of £200/kg P (assumed cost effectiveness of removal of P directly from lochs), leading to a total cost of £189 m/y. Lochs were ranked by mitigation costs per loch area to give a national scale marginal mitigation cost curve. A published choice experiment valuation of WFD targets for Scottish lochs was used to estimate marginal benefits at national scale and combined with the marginal cost curve. This gave proportionate costs of £5.7 m/y leading to GES in 72% of loch area. Using national mean marginal benefits with a scheme to estimate changes in individual loch value with P loading gave proportionate costs of £25.6 m/y leading to GES in 77% of loch area (491 lochs). Copyright © 2011 Elsevier Ltd. All rights reserved.

Concepts in Environmental Education.

ERIC Educational Resources Information Center

Hopkins, Sally

Presented is a discussion of the components and concepts of an ecology typical of the coastal southeastern United States. Principles presented are applicable to other areas. The discussion includes several major sections: the environment, wildlife management, freshwater ecosystems, and the estuarine environment. Numerous figures and illustrations…

Remote Sensing of Earth and Environment

ERIC Educational Resources Information Center

Schertler, Ronald J.

1974-01-01

Discusses basic principles of remote sensing applications and five areas of the earth resources survey program: agriculture and forestry production; geography, cartography, cultural resources; geology and mineral resources; hydrology and water resources; and oceanography and marine resources. Indicates that information acquisition is the first…

Prosthetic EMG control enhancement through the application of man-machine principles

NASA Technical Reports Server (NTRS)

Simcox, W. A.

1977-01-01

An area in medicine that appears suitable to man-machine principles is rehabilitation research, particularly when the motor aspects of the body are involved. If one considers the limb, whether functional or not, as the machine, the brain as the controller and the neuromuscular system as the man-machine interface, the human body is reduced to a man-machine system that can benefit from the principles behind such systems. The area of rehabilitation that this paper deals with is that of an arm amputee and his prosthetic device. Reducing this area to its man-machine basics, the problem becomes one of attaining natural multiaxis prosthetic control using Electromyographic activity (EMG) as the means of communication between man and prothesis. In order to use EMG as the communication channel it must be amplified and processed to yield a high information signal suitable for control. The most common processing scheme employed is termed Mean Value Processing. This technique for extracting the useful EMG signal consists of a differential to single ended conversion to the surface activity followed by a rectification and smoothing.

The Rosiwal Principle and the regolithic distributions of solar-wind elements

NASA Technical Reports Server (NTRS)

Criswell, D. R.

1975-01-01

In situ accumulation of solar elements is studied for the purpose of determining the extent of applicability of the Rosiwal Principle. The Rosiwal Principle states that the grain exposure area is proportional to the fraction of the unit volume occupied by the grains, and the test involves measurement of the relative concentrations of inert gases and reactive elements across sets of lunar fines samples for which mean grain size, sorting, and minimum radius of surface correlation are known. In some cases, the quantity of an element implanted into the lunar fines from the solar wind is found to be surface correlated, and the implications of this relationship are considered. According to the Rosiwal Principle, coarse soils should retain less inert gas than fine soil. The Principle can also be applied to species volatized or sputtered from the lunar surface and redeposited locally.

The simplicity principle in perception and cognition

PubMed Central

Feldman, Jacob

2016-01-01

The simplicity principle, traditionally referred to as Occam’s razor, is the idea that simpler explanations of observations should be preferred to more complex ones. In recent decades the principle has been clarified via the incorporation of modern notions of computation and probability, allowing a more precise understanding of how exactly complexity minimization facilitates inference. The simplicity principle has found many applications in modern cognitive science, in contexts as diverse as perception, categorization, reasoning, and neuroscience. In all these areas, the common idea is that the mind seeks the simplest available interpretation of observations— or, more precisely, that it balances a bias towards simplicity with a somewhat opposed constraint to choose models consistent with perceptual or cognitive observations. This brief tutorial surveys some of the uses of the simplicity principle across cognitive science, emphasizing how complexity minimization in a number of forms has been incorporated into probabilistic models of inference. PMID:27470193

Shedding Light on Fiber Optics.

ERIC Educational Resources Information Center

Bunch, Robert M.

1994-01-01

Explains the principles of fiber optics as a medium for light-wave communication. Current uses of fiber systems on college campuses include voice, video, and local area network applications. A group of seven school districts in Minnesota are linked via fiber-optic cables. Other uses are discussed. (MLF)

Theme: Agricultural Education and Distance Education.

ERIC Educational Resources Information Center

Murphy, Tim H.; And Others

1996-01-01

Includes "The Time Is Now" (Murphy); "Technological Solution in Search of an Instructional Problem" (Willis, Touchstone); "'Principles' of Distance Education" (Peasley); "A Star Is Born!" (Swan); "Enrichment in the Classroom" (Blume, Talbert); "Practical Applications for Distance Education Technologies in Remote and Rural Areas" (Davis, Frick);…

Discrimination in Employment.

ERIC Educational Resources Information Center

McCarthy, Martha M.

An overview is presented of litigation in which courts have interpreted educational employees' rights to nondiscriminatory treatment and employers' obligations to ensure equal employment opportunities. Because of the range, volume, and complexity of the litigation in this area, the intent is to identify applicable legal principles rather than to…

Principles for research on ethnicity and health: the Leeds Consensus Statement.

PubMed

Mir, Ghazala; Salway, Sarah; Kai, Joe; Karlsen, Saffron; Bhopal, Raj; Ellison, George Th; Sheikh, Aziz

2013-06-01

There is substantial evidence that health and health-care experiences vary along ethnic lines and the need to understand and tackle ethnic health inequalities has repeatedly been highlighted. Research into ethnicity and health raises ethical, theoretical and methodological issues and, as the volume of research in this area grows, so too do concerns regarding its scientific rigour and reporting, and its contribution to reducing inequalities. Guidance may be helpful in encouraging researchers to adopt standard practices in the design, conduct and reporting of research. However, past efforts at introducing such guidance have had limited impact on research practice, and the diversity of disciplinary perspectives on the key challenges and solutions may undermine attempts to derive and promote guiding principles. A consensus building Delphi exercise--the first of its kind in this area of research practice--was undertaken with leading academics, practitioners and policymakers from a broad range of disciplinary backgrounds to assess whether consensus on key principles could be achieved. Ten key principles for conducting research on ethnicity and health emerged, covering: the aims of research in this field; how such research should be framed and focused; key design-related considerations; and the direction of future research. Despite some areas of dispute, participants were united by a common concern that the generation and application of research evidence should contribute to better health-care experiences and health outcomes for minority ethnic people. The principles provide a strong foundation to guide future ethnicity-related research and build a broader international consensus.

The precautionary principle and pharmaceutical risk management.

PubMed

Callréus, Torbjörn

2005-01-01

Although it is often vigorously contested and has several different formulations, the precautionary principle has in recent decades guided environmental policy making in the face of scientific uncertainty. Originating from a criticism of traditional risk assessment, the key element of the precautionary principle is the justification for acting in the face of uncertain knowledge about risks. In the light of its growing invocation in various areas that are related to public health and recently in relation to drug safety issues, this article presents an introductory review of the main elements of the precautionary principle and some arguments conveyed by its advocates and opponents. A comparison of the characteristics of pharmaceutical risk management and environmental policy making (i.e. the setting within which the precautionary principle evolved), indicates that several important differences exist. If believed to be of relevance, in order to avoid arbitrary and unpredictable decision making, both the interpretation and possible application of the precautionary principle need to be adapted to the conditions of pharmaceutical risk management.

The principle of proportionality revisited: interpretations and applications.

PubMed

Hermerén, Göran

2012-11-01

The principle of proportionality is used in many different contexts. Some of these uses and contexts are first briefly indicated. This paper focusses on the use of this principle as a moral principle. I argue that under certain conditions the principle of proportionality is helpful as a guide in decision-making. But it needs to be clarified and to be used with some flexibility as a context-dependent principle. Several interpretations of the principle are distinguished, using three conditions as a starting point: importance of objective, relevance of means, and most favourable option. The principle is then tested against an example, which suggests that a fourth condition, focusing on non-excessiveness, needs to be added. I will distinguish between three main interpretations of the principle, some primarily with uses in research ethics, others with uses in other areas of bioethics, for instance in comparisons of therapeutic means and ends. The relations between the principle of proportionality and the precautionary principle are explored in the following section. It is concluded that the principles are different and may even clash. In the next section the principle of proportionality is applied to some medical examples drawn from research ethics and bioethics. In concluding, the status of the principle of proportionality as a moral principle is discussed. What has been achieved so far and what remains to be done is finally summarized.

Principles and Applications of Physical Fitness: Course Proposal.

ERIC Educational Resources Information Center

Yeo, David G.

A proposal is presented for a Community College of Philadelphia Life Sciences and Allied Health Services course in physical fitness. Following a standard cover form, a statement of purpose explains that the course is designed to provide instruction and experience in the basic areas of nutrition and physical conditioning, including dietary…

Applying Services Marketing Principles to Postgraduate Supervision

ERIC Educational Resources Information Center

Dann, Stephen

2008-01-01

Purpose: The paper aims to describe the application of two key service quality frameworks for improving the delivery of postgraduate research supervision. The services quality frameworks are used to identify key areas of overlap between services marketing practice and postgraduate supervision that can be used by the supervisor to improve research…

Application of Statistical Quality Control Techniques to Detonator Fabrication: Feasibility Study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jones, J. Frank

1971-05-20

A feasibility study was performed on the use of process control techniques which might reduce the need for a duplicate inspection by production inspection and quality control inspection. Two active detonator fabrication programs were selected for the study. Inspection areas accounting for the greatest percentage of total inspection costs were selected by applying "Pareto's Principle of Maldistribution." Data from these areas were then gathered and analyzed by a process capabiltiy study.

Energy conversion and storage program

NASA Astrophysics Data System (ADS)

Cairns, E. J.

1992-03-01

The Energy Conversion and Storage Program applies chemistry and materials science principles to solve problems in: (1) production of new synthetic fuels; (2) development of high-performance rechargeable batteries and fuel cells; (3) development of advanced thermochemical processes for energy conversion; (4) characterization of complex chemical processes; and (5) application of novel materials for energy conversion and transmission. Projects focus on transport-process principles, chemical kinetics, thermodynamics, separation processes, organic and physical chemistry, novel materials, and advanced methods of analysis. Electrochemistry research aims to develop advanced power systems for electric vehicle and stationary energy storage applications. Topics include identification of new electrochemical couples for advanced rechargeable batteries, improvements in battery and fuel-cell materials, and the establishment of engineering principles applicable to electrochemical energy storage and conversion. Chemical Applications research includes topics such as separations, catalysis, fuels, and chemical analyses. Included in this program area are projects to develop improved, energy-efficient methods for processing waste streams from synfuel plants and coal gasifiers. Other research projects seek to identify and characterize the constituents of liquid fuel-system streams and to devise energy-efficient means for their separation. Materials Applications research includes the evaluation of the properties of advanced materials, as well as the development of novel preparation techniques. For example, the use of advanced techniques, such as sputtering and laser ablation, are being used to produce high-temperature superconducting films.

A Novel Physical Sensing Principle for Liquid Characterization Using Paper-Based Hygro-Mechanical Systems (PB-HMS).

PubMed

Perez-Cruz, Angel; Stiharu, Ion; Dominguez-Gonzalez, Aurelio

2017-07-20

In recent years paper-based microfluidic systems have emerged as versatile tools for developing sensors in different areas. In this work; we report a novel physical sensing principle for the characterization of liquids using a paper-based hygro-mechanical system (PB-HMS). The PB-HMS is formed by the interaction of liquid droplets and paper-based mini-structures such as cantilever beams. The proposed principle takes advantage of the hygroscopic properties of paper to produce hygro-mechanical motion. The dynamic response of the PB-HMS reveals information about the tested liquid that can be applied to characterize certain properties of liquids. A suggested method to characterize liquids by means of the proposed principle is introduced. The experimental results show the feasibility of such a method. It is expected that the proposed principle may be applied to sense properties of liquids in different applications where both disposability and portability are of extreme importance.

Pharmacological aspects of release from microcapsules - from polymeric multilayers to lipid membranes.

PubMed

Wuytens, Pieter; Parakhonskiy, Bogdan; Yashchenok, Alexey; Winterhalter, Mathias; Skirtach, Andre

2014-10-01

This review is devoted to pharmacological applications of principles of release from capsules to overcome the membrane barrier. Many of these principles were developed in the context of polymeric multilayer capsule membrane modulation, but they are also pertinent to liposomes, polymersomes, capsosomes, particles, emulsion-based carriers and other carriers. We look at these methods from the physical, chemical or biological driving mechanisms point of view. In addition to applicability for carriers in drug delivery, these release methods are significant for another area directly related to pharmacology - modulation of the permeability of the membranes and thus promoting the action of drugs. Emerging technologies, including ionic current monitoring through a lipid membrane on a nanopore, are also highlighted. Copyright © 2014 Elsevier Ltd. All rights reserved.

AN APPLICATION OF REINFORCEMENT PRINCIPLES TO CLASSROOM TEACHING.

ERIC Educational Resources Information Center

PORTER, DOUGLAS

THIS RESEARCH CONSIDERED THE TEACHING OF SPELLING AS A PHENOMENON MORE OR LESS ISOLATED FROM THE OTHER AREAS OF LANGUAGE ARTS INSTRUCTION THAT PROBABLY CONTRIBUTE TO SPELLING PERFORMANCE. THE MAJOR OBJECTIVES WERE--(1) TO DESIGN, CONSTRUCT, AND TEST MECHANICAL DEVICES FOR THE TEACHING OF SPELLING, AND (2) TO CARRY OUT AN EXPLORATORY INVESTIGATION…

Teaching Strategies and Methods in Modern Environments for Learning of Programming

ERIC Educational Resources Information Center

Djenic, Slobodanka; Mitic, Jelena

2017-01-01

This paper presents teaching strategies and methods, applicable in modern blended environments for learning of programming. Given the fact that the manner of applying teaching strategies always depends on the specific requirements of a certain area of learning, the paper outlines the basic principles of teaching in programming courses, as well as…

WE-G-12A-01: High Intensity Focused Ultrasound Surgery and Therapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Farahani, K; O'Neill, B

More and more emphasis is being made on alternatives to invasive surgery and the use of ionizing radiation to treat various diseases including cancer. Novel screening, diagnosis, treatment and monitoring of response to treatment are also hot areas of research and new clinical technologies. Ultrasound(US) has gained traction in all of the aforementioned areas of focus. Especially with recent advances in the use of ultrasound to noninvasively treat various diseases/organ systems. This session will focus on covering MR-guided focused ultrasound and the state of the art clinical applications, and the second speaker will survey the more cutting edge technologies e.g.more » Focused Ultrasound (FUS) mediated drug delivery, principles of cavitation and US guided FUS. Learning Objectives: Fundamental physics and physical limitations of US interaction with tissue and nanoparticles The alteration of tissue transport using focused ultrasound US control of nanoparticle drug carriers for targeted release The basic principles of MRI-guided focused ultrasound (MRgFUS) surgery and therapy the current state of the art clinical applications of MRgFUS requirements for quality assurance and treatment planning.« less

Emergency managers as change agents: recognizing the value of management, leadership, and strategic management in the disaster profession.

PubMed

Urby, Heriberto; McEntire, David A

2015-01-01

This article discusses the influence of management theory, some principles of leadership, four strategic management considerations, that are applied to emergency management, allow emergency managers to transform their followers, organizations, and communities at large. The authors argue that in the past there has been little recognition of the value, or application, of these three areas of emphasis in the disaster profession. Using more of these principles, emergency managers may transform into transformational change agents who make a difference in their followers' lives, who themselves transform other people and improve emergency management.

A calculation and uncertainty evaluation method for the effective area of a piston rod used in quasi-static pressure calibration

NASA Astrophysics Data System (ADS)

Gu, Tingwei; Kong, Deren; Shang, Fei; Chen, Jing

2018-04-01

This paper describes the merits and demerits of different sensors for measuring propellant gas pressure, the applicable range of the frequently used dynamic pressure calibration methods, and the working principle of absolute quasi-static pressure calibration based on the drop-weight device. The main factors affecting the accuracy of pressure calibration are analyzed from two aspects of the force sensor and the piston area. To calculate the effective area of the piston rod and evaluate the uncertainty between the force sensor and the corresponding peak pressure in the absolute quasi-static pressure calibration process, a method for solving these problems based on the least squares principle is proposed. According to the relevant quasi-static pressure calibration experimental data, the least squares fitting model between the peak force and the peak pressure, and the effective area of the piston rod and its measurement uncertainty, are obtained. The fitting model is tested by an additional group of experiments, and the peak pressure obtained by the existing high-precision comparison calibration method is taken as the reference value. The test results show that the peak pressure obtained by the least squares fitting model is closer to the reference value than the one directly calculated by the cross-sectional area of the piston rod. When the peak pressure is higher than 150 MPa, the percentage difference is less than 0.71%, which can meet the requirements of practical application.

GPU computing in medical physics: a review.

PubMed

Pratx, Guillem; Xing, Lei

2011-05-01

The graphics processing unit (GPU) has emerged as a competitive platform for computing massively parallel problems. Many computing applications in medical physics can be formulated as data-parallel tasks that exploit the capabilities of the GPU for reducing processing times. The authors review the basic principles of GPU computing as well as the main performance optimization techniques, and survey existing applications in three areas of medical physics, namely image reconstruction, dose calculation and treatment plan optimization, and image processing.

Principles, Techniques, and Applications of Tissue Microfluidics

NASA Technical Reports Server (NTRS)

Wade, Lawrence A.; Kartalov, Emil P.; Shibata, Darryl; Taylor, Clive

2011-01-01

The principle of tissue microfluidics and its resultant techniques has been applied to cell analysis. Building microfluidics to suit a particular tissue sample would allow the rapid, reliable, inexpensive, highly parallelized, selective extraction of chosen regions of tissue for purposes of further biochemical analysis. Furthermore, the applicability of the techniques ranges beyond the described pathology application. For example, they would also allow the posing and successful answering of new sets of questions in many areas of fundamental research. The proposed integration of microfluidic techniques and tissue slice samples is called tissue microfluidics because it molds the microfluidic architectures in accordance with each particular structure of each specific tissue sample. Thus, microfluidics can be built around the tissues, following the tissue structure, or alternatively, the microfluidics can be adapted to the specific geometry of particular tissues. By contrast, the traditional approach is that microfluidic devices are structured in accordance with engineering considerations, while the biological components in applied devices are forced to comply with these engineering presets. The proposed principles represent a paradigm shift in microfluidic technology in three important ways: Microfluidic devices are to be directly integrated with, onto, or around tissue samples, in contrast to the conventional method of off-chip sample extraction followed by sample insertion in microfluidic devices. Architectural and operational principles of microfluidic devices are to be subordinated to suit specific tissue structure and needs, in contrast to the conventional method of building devices according to fluidic function alone and without regard to tissue structure. Sample acquisition from tissue is to be performed on-chip and is to be integrated with the diagnostic measurement within the same device, in contrast to the conventional method of off-chip sample prep and subsequent insertion into a diagnostic device. A more advanced form of tissue integration with microfluidics is tissue encapsulation, wherein the sample is completely encapsulated within a microfluidic device, to allow for full surface access. The immediate applications of these approaches lie with diagnostics of tissue slices and biopsy samples e.g. for cancer but the approaches would also be very useful in comparative genomics and other areas of fundamental research involving heterogeneous tissue samples.

10 CFR 1023.3 - Principles of general applicability.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Principles of general applicability. 1023.3 Section 1023.3 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) CONTRACT APPEALS Overview: Organization, Functions and Authorities § 1023.3 Principles of general applicability. (a) Adjudicatory functions. The following principles...

Lightweight Composite Materials for Heavy Duty Vehicles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pruez, Jacky; Shoukry, Samir; Williams, Gergis

The main objective of this project is to develop, analyze and validate data, methodologies and tools that support widespread applications of automotive lightweighting technologies. Two underlying principles are guiding the research efforts towards this objective: • Seamless integration between the lightweight materials selected for certain vehicle systems, cost-effective methods for their design and manufacturing, and practical means to enhance their durability while reducing their Life-Cycle-Costs (LCC). • Smooth migration of the experience and findings accumulated so far at WVU in the areas of designing with lightweight materials, innovative joining concepts and durability predictions, from applications to the area of weightmore » savings for heavy vehicle systems and hydrogen storage tanks, to lightweighting applications of selected systems or assemblies in light–duty vehicles.« less

Inclusive and relevant language: the use of the concepts of autonomy, dignity and vulnerability in different contexts.

PubMed

Haugen, Hans Morten

2010-08-01

The article analyses the three terms autonomy, dignity and vulnerability. The relevance and practical application of the terms is tested in two spheres. First, as guiding principles in the area of ethics of medicines and science. Second, as human rights principles, serving to guide the conduct of public policies for an effective realization of human rights. The article argues that all human beings have the same dignity, but that the autonomy--and therefore vulnerability--differs considerably. Simply said, with reduced autonomy comes increased vulnerability, implying extra attention to the protective dimensions. The article finds that the three terms approach the protection of human beings in different ways and that all are relevant and applicable in both spheres, but that an isolated notion of autonomy and a 'group-based' notion of vulnerability are not adequate.

Impulse Response Shaping for Ultra Wide Band SAR in a Circular Flight Path

NASA Technical Reports Server (NTRS)

Jin, Michael Y.

1996-01-01

An ultra wide band SAR (synthetic aperture radar) has potential applications on imaging underground objects. Flying this SAR in a circular flight path is an efficient way to acquire high resolution images from a localized area. This paper characterizes the impulse response of sucha system. The results indicate that to achieve an image with a more uniformed resolution over the entire imaged area, proper weighting coeficients should be applied to both the principle aperture and the complimentary aperture.

Principles of Micellar Electrokinetic Capillary Chromatography Applied in Pharmaceutical Analysis

PubMed Central

Hancu, Gabriel; Simon, Brigitta; Rusu, Aura; Mircia, Eleonora; Gyéresi, Árpád

2013-01-01

Since its introduction capillary electrophoresis has shown great potential in areas where electrophoretic techniques have rarely been used before, including here the analysis of pharmaceutical substances. The large majority of pharmaceutical substances are neutral from electrophoretic point of view, consequently separations by the classic capillary zone electrophoresis; where separation is based on the differences between the own electrophoretic mobilities of the analytes; are hard to achieve. Micellar electrokinetic capillary chromatography, a hybrid method that combines chromatographic and electrophoretic separation principles, extends the applicability of capillary electrophoretic methods to neutral analytes. In micellar electrokinetic capillary chromatography, surfactants are added to the buffer solution in concentration above their critical micellar concentrations, consequently micelles are formed; micelles that undergo electrophoretic migration like any other charged particle. The separation is based on the differential partitioning of an analyte between the two-phase system: the mobile aqueous phase and micellar pseudostationary phase. The present paper aims to summarize the basic aspects regarding separation principles and practical applications of micellar electrokinetic capillary chromatography, with particular attention to those relevant in pharmaceutical analysis. PMID:24312804

Collected Papers Prepared Under Work Unit TEXTRUCT: Methods of Instruction in Technical Training.

ERIC Educational Resources Information Center

Human Resources Research Organization, Alexandria, VA.

Although the concept of automated instruction is not new, it has gained major support only in the past 3 years. These 12 papers describe research in the area of instructional methods for technical training. The scientific principles of learning and their applicability to automated instruction are discussed, with emphasis on the role of automated…

Application of Principles of Total Quality Management (TQM) in Teacher Education Institutions

ERIC Educational Resources Information Center

Manivannan, M.; Premila, K. S.

2009-01-01

The indomitable spirit of higher education paves the way for the growth of a nation in the political, economic, social, intellectual and spiritual dimensions. Teacher education is one of the areas in higher education which trains student-teachers in pedagogy, which in turn helps them to train the young minds of educational institutions. The…

Optical Inference Machines

DTIC Science & Technology

1988-06-27

de olf nessse end Id e ;-tl Sb ieeI smleo) ,Optical Artificial Intellegence ; Optical inference engines; Optical logic; Optical informationprocessing...common. They arise in areas such as expert systems and other artificial intelligence systems. In recent years, the computer science language PROLOG has...cal processors should in principle be well suited for : I artificial intelligence applications. In recent years, symbolic logic processing. , the

Knowledge Diffusion in the Context of Development in Rural Areas. Keynote Address.

ERIC Educational Resources Information Center

Martinez-Brawley, Emilia E.

This paper analyzes principles of knowledge diffusion and provides a framework for applying new ideas or innovations, particularly in relation to rural community development. As new knowledge is created or old knowledge is found to have new applications, the art of spreading knowledge and managing innovation has become more crucial in both urban…

Large-Area Plasma-Panel Radiation Detectors for Nuclear Medicine Imaging to Homeland Security and the Super Large Hadron Collider

DOE Office of Scientific and Technical Information (OSTI.GOV)

Friedman, Dr. Peter S.; Ball, Robert; Chapman, J. Wehrley

2010-01-01

A new radiation sensor derived from plasma panel display technology is introduced. It has the capability to detect ionizing and non-ionizing radiation over a wide energy range and the potential for use in many applications. The principle of operation is described and some early results presented.

Studying Current-Potential Curves Using a Bipotentiometric Lodometric Back-Titration for the Determination of Ascorbic Acid in Fruits and Vegetables

ERIC Educational Resources Information Center

Verdini, Roxana A.; Lagier, Claudia M.

2004-01-01

Voltammetry principles are introduced to students by means of a bipotentiometric method to determine vitamin C in fruits and vegetables. The aim is to draw attention to voltammetric methods, particular to the study of current-potential curves, stressing the potential applicability in areas of food quality control.

INSTRUCTIONAL TELEVISION FOR THE LOWER PRIMARY. A TEACHER GUIDE, SEMESTER II.

ERIC Educational Resources Information Center

PELIKAN, ALFRED; AND OTHERS

PROGRAMS FOR THE LOWER PRIMARY GROUP WERE IN ART, MUSIC AND PHYSICAL EDUCATION. A PREVIEW OF THE CONTENT OF EACH TELECAST WAS GIVEN WITH DETAILED INFORMATION FOR FOLLOWUP ACTIVITIES. THE STRUCTURE OF THE ART PROGRAM INCLUDED THE FUNDAMENTAL PRINCIPLES APPLICABLE TO SUCH BASIC AREAS AS LINE DRAWING, PICTURE MAKING, DESIGN AND CONSTRUCTION WITH THE…

Tethers in space handbook

NASA Technical Reports Server (NTRS)

Reese, T. G.; Baracat, W. A.; Butner, C. L.

1986-01-01

The handbook provides a list and description of ongoing tether programs. This includes the joint U.S.-Italy demonstration project, and individual U.S. and Italian studies and demonstration programs. An overview of the current activity level and areas of emphasis in this emerging field is provided. The fundamental physical principles behind the proposed tether applications are addressed. Four basic concepts of gravity gradient, rotation, momentum exchange, and electrodynamics are discussed. Information extracted from literature, which supplements and enhances the tether applications is also presented. A bibliography is appended.

Controlled release of molecular components of dendrimer/bioactive complexes

DOEpatents

Segalman, Daniel J.; Wallace, J. Shield

1998-01-01

A method for releasing molecules (guest molecules) from the matrix formed by the structure of another molecule (host molecule) in a controllable manner has been invented. This method has many applications in science and industry. In addition, applications based on such molecular systems may revolutionize significant areas of medicine, in particular the treatment of cancer and of viral infection. Similar effects can also be obtained by controlled fragmentation of a source molecule, where the molecular fragments form the active principle.

Controlled release of molecular components of dendrimer/bioactive complexes

DOEpatents

Segalman, D.J.; Wallace, J.S.

1998-08-18

A method for releasing molecules (guest molecules) from the matrix formed by the structure of another molecule (host molecule) in a controllable manner has been invented. This method has many applications in science and industry. In addition, applications based on such molecular systems may revolutionize significant areas of medicine, in particular the treatment of cancer and of viral infection. Similar effects can also be obtained by controlled fragmentation of a source molecule, where the molecular fragments form the active principle. 13 figs.

Applications of geohydrologic concepts in geology

USGS Publications Warehouse

Maxey, G.B.; Hackett, J.E.

1963-01-01

Subsurface water, an active agent in many geologic proceses, must be considered in interpreting geologic phenomena. Principles of the occurrence, distribution, and movement of subsurface waters are well established and readily applicable. In many interpretations in geologic literature, geohydrologic principles have been employed realistically, but in many others these principles have been either ignored or violated. Explanations of genesis of underclays and associated deposits afford some examples wherein principles of movement and activity of vadose and ground water have been ignored and others in which they have been used advantageously. Postulates stating that waters percolate downward from swamp areas do not allow for the usual movement of subsurface water in such environments. The idea that sediments were leached by vadose water after uplift satisfies the geohydrologic requirements. Weathering and solution form porous and permeable zones subjacent to unconformities in dense rocks such as carbonates and granites; this illustrates the geohydrologic and economic significance of unconformities. Examples are Mohawkian carbonate aquifers of northern Illinois and oil-bearing limestones of Mississippian age of eastern Montana. The flushing effects of meteoric water and other hydrodynamic factors active during erosion periods are important elements in the genesis and concentration of brines. Explanation of the origin and occurrence of brines must include consideration of the geohydrologic environments throughout their geologic history. ?? 1963.

Principles for fostering the transdisciplinary development of assistive technologies.

PubMed

Boger, Jennifer; Jackson, Piper; Mulvenna, Maurice; Sixsmith, Judith; Sixsmith, Andrew; Mihailidis, Alex; Kontos, Pia; Miller Polgar, Janice; Grigorovich, Alisa; Martin, Suzanne

2017-07-01

Developing useful and usable assistive technologies often presents complex (or "wicked") challenges that require input from multiple disciplines and sectors. Transdisciplinary collaboration can enable holistic understanding of challenges that may lead to innovative, impactful and transformative solutions. This paper presents generalised principles that are intended to foster transdisciplinary assistive technology development. The paper introduces the area of assistive technology design before discussing general aspects of transdisciplinary collaboration followed by an overview of relevant concepts, including approaches, methodologies and frameworks for conducting and evaluating transdisciplinary working and assistive technology design. The principles for transdisciplinary development of assistive technologies are presented and applied post hoc to the COACH project, an ambient-assisted living technology for guiding completion of activities of daily living by older adults with dementia as an illustrative example. Future work includes the refinement and validation of these principles through their application to real-world transdisciplinary assistive technology projects. Implications for rehabilitation Transdisciplinarity encourages a focus on real world 'wicked' problems. A transdisciplinary approach involves transcending disciplinary boundaries and collaborating with interprofessional and community partners (including the technology's intended users) on a shared problem. Transdisciplinarity fosters new ways of thinking about and doing research, development, and implementation, expanding the scope, applicability, and commercial viability of assistive technologies.

Hair transplantation to the eyebrow, eyelashes, and other parts of the body.

PubMed

Gandelman, Marcelo; Epstein, Jeffrey S

2004-05-01

Since its earliest applications, hair transplantation has been used for treating not only the scalp in pattern baldness but also other parts of the body, commencing with eyebrow reconstruction. The earliest micrografts were applied to the eyebrow more than 30 years before their application to the scalp became the standard of care. Today hair transplantation is applied to a number of other areas. The principle behind transplanting these areas is the same-once transplanted, the hairs continue to grow because of the phenomenon of donor dominance. This article reviews the role and technique of hair transplantation to the eyebrows and eyelids, chest, beard and moustache, and pubic escutcheon.

Principles, Techniques, and Applications of Tissue Microfluidics

NASA Technical Reports Server (NTRS)

Wade, Lawrence A.; Kartalov, Emil P.; Shibata, Darryl; Taylor, Clive

2011-01-01

The principle of tissue microfluidics and its resultant techniques has been applied to cell analysis. Building microfluidics to suit a particular tissue sample would allow the rapid, reliable, inexpensive, highly parallelized, selective extraction of chosen regions of tissue for purposes of further biochemical analysis. Furthermore, the applicability of the techniques ranges beyond the described pathology application. For example, they would also allow the posing and successful answering of new sets of questions in many areas of fundamental research. The proposed integration of microfluidic techniques and tissue slice samples is called "tissue microfluidics" because it molds the microfluidic architectures in accordance with each particular structure of each specific tissue sample. Thus, microfluidics can be built around the tissues, following the tissue structure, or alternatively, the microfluidics can be adapted to the specific geometry of particular tissues. By contrast, the traditional approach is that microfluidic devices are structured in accordance with engineering considerations, while the biological components in applied devices are forced to comply with these engineering presets.

How much drinking water can be saved by using rainwater harvesting on a large urban area? application to Paris agglomeration.

PubMed

Belmeziti, Ali; Coutard, Olivier; de Gouvello, Bernard

2014-01-01

This paper is based on a prospective scenario of development of rainwater harvesting (RWH) on a given large urban area (such as metropolitan area or region). In such a perspective, a new method is proposed to quantify the related potential of potable water savings (PPWS) indicator on this type of area by adapting the reference model usually used on the building level. The method is based on four setting-up principles: gathering (definition of buildings-types and municipalities-types), progressing (use of an intermediate level), increasing (choice of an upper estimation) and prioritizing (ranking the stakes of RWH). Its application to the Paris agglomeration shows that is possible to save up to 11% of the total current potable water through the use of RWH. It also shows that the residential sector offers the most important part because it holds two-thirds of the agglomeration PPWS.

10 CFR 603.625 - Cost principles or standards applicable to for-profit participants.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Accounting Principles (see Statement of Financial Accounting Standards Number 2, “Accounting for Research and... Financial Matters § 603.625 Cost principles or standards applicable to for-profit participants. (a) So as... 10 Energy 4 2010-01-01 2010-01-01 false Cost principles or standards applicable to for-profit...

Applying the cognitive theory of multimedia learning: an analysis of medical animations.

PubMed

Yue, Carole; Kim, Jessie; Ogawa, Rikke; Stark, Elena; Kim, Sara

2013-04-01

Instructional animations play a prominent role in medical education, but the degree to which these teaching tools follow empirically established learning principles, such as those outlined in the cognitive theory of multimedia learning (CTML), is unknown. These principles provide guidelines for designing animations in a way that promotes optimal cognitive processing and facilitates learning, but the application of these learning principles in current animations has not yet been investigated. A large-scale review of existing educational tools in the context of this theoretical framework is necessary to examine if and how instructional medical animations adhere to these principles and where improvements can be made. We conducted a comprehensive review of instructional animations in the health sciences domain and examined whether these animations met the three main goals of CTML: managing essential processing; minimising extraneous processing, and facilitating generative processing. We also identified areas for pedagogical improvement. Through Google keyword searches, we identified 4455 medical animations for review. After the application of exclusion criteria, 860 animations from 20 developers were retained. We randomly sampled and reviewed 50% of the identified animations. Many animations did not follow the recommended multimedia learning principles, particularly those that support the management of essential processing. We also noted an excess of extraneous visual and auditory elements and few opportunities for learner interactivity. Many unrealised opportunities exist for improving the efficacy of animations as learning tools in medical education; instructors can look to effective examples to select or design animations that incorporate the established principles of CTML. © Blackwell Publishing Ltd 2013.

Interrogating discourse: the application of Foucault's methodological discussion to specific inquiry.

PubMed

Fadyl, Joanna K; Nicholls, David A; McPherson, Kathryn M

2013-09-01

Discourse analysis following the work of Michel Foucault has become a valuable methodology in the critical analysis of a broad range of topics relating to health. However, it can be a daunting task, in that there seems to be both a huge number of possible approaches to carrying out this type of project, and an abundance of different, often conflicting, opinions about what counts as 'Foucauldian'. This article takes the position that methodological design should be informed by ongoing discussion and applied as appropriate to a particular area of inquiry. The discussion given offers an interpretation and application of Foucault's methodological principles, integrating a reading of Foucault with applications of his work by other authors, showing how this is then applied to interrogate the practice of vocational rehabilitation. It is intended as a contribution to methodological discussion in this area, offering an interpretation of various methodological elements described by Foucault, alongside specific application of these aspects.

The simplicity principle in perception and cognition.

PubMed

Feldman, Jacob

2016-09-01

The simplicity principle, traditionally referred to as Occam's razor, is the idea that simpler explanations of observations should be preferred to more complex ones. In recent decades the principle has been clarified via the incorporation of modern notions of computation and probability, allowing a more precise understanding of how exactly complexity minimization facilitates inference. The simplicity principle has found many applications in modern cognitive science, in contexts as diverse as perception, categorization, reasoning, and neuroscience. In all these areas, the common idea is that the mind seeks the simplest available interpretation of observations- or, more precisely, that it balances a bias toward simplicity with a somewhat opposed constraint to choose models consistent with perceptual or cognitive observations. This brief tutorial surveys some of the uses of the simplicity principle across cognitive science, emphasizing how complexity minimization in a number of forms has been incorporated into probabilistic models of inference. WIREs Cogn Sci 2016, 7:330-340. doi: 10.1002/wcs.1406 For further resources related to this article, please visit the WIREs website. © 2016 Wiley Periodicals, Inc.

Optical monitoring of scoliosis by 3D medical laser scanner

NASA Astrophysics Data System (ADS)

Rodríguez-Quiñonez, Julio C.; Sergiyenko, Oleg Yu.; Preciado, Luis C. Basaca; Tyrsa, Vera V.; Gurko, Alexander G.; Podrygalo, Mikhail A.; Lopez, Moises Rivas; Balbuena, Daniel Hernandez

2014-03-01

Three dimensional recording of the human body surface or anatomical areas have gained importance in many medical applications. In this paper, our 3D Medical Laser Scanner is presented. It is based on the novel principle of dynamic triangulation. We analyze the method of operation, medical applications, orthopedically diseases as Scoliosis and the most common types of skin to employ the system the most proper way. It is analyzed a group of medical problems related to the application of optical scanning in optimal way. Finally, experiments are conducted to verify the performance of the proposed system and its method uncertainty.

Technological inductive power transfer systems

NASA Astrophysics Data System (ADS)

Madzharov, Nikolay D.; Nemkov, Valentin S.

2017-05-01

Inductive power transfer is a very fast expanding technology with multiple design principles and practical implementations ranging from charging phones and computers to bionic systems, car chargers and continuous power transfer in technological lines. Only a group of devices working in near magnetic field is considered. This article is devoted to overview of different inductive power transfer (IPT) devices. The review of literature in this area showed that industrial IPT are not much discussed and examined. The authors have experience in design and implementation of several types of IPTs belonging to wireless automotive chargers and to industrial application group. Main attention in the article is paid to principles and design of technological IPTs

26 CFR 1.671-2 - Applicable principles.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Applicable principles. 1.671-2 Section 1.671-2...) INCOME TAXES Grantors and Others Treated As Substantial Owners § 1.671-2 Applicable principles. (a) Under... included in a portion of the trust are set forth in § 1.671-3. (b) Since the principle underlying subpart E...

Applying the ecosystem approach to select priority areas for forest landscape restoration in the Yungas, Northwestern Argentina.

PubMed

Ianni, Elena; Geneletti, Davide

2010-11-01

This paper proposes a method to select forest restoration priority areas consistently with the key principles of the Ecosystem Approach (EA) and the Forest Landscape Restoration (FLR) framework. The methodology is based on the principles shared by the two approaches: acting at ecosystem scale, involving stakeholders, and evaluating alternatives. It proposes the involvement of social actors which have a stake in forest management through multicriteria analysis sessions aimed at identifying the most suitable forest restoration intervention. The method was applied to a study area in the native forests of Northern Argentina (the Yungas). Stakeholders were asked to identify alternative restoration actions, i.e. potential areas implementing FLR. Ten alternative fincas-estates derived from the Spanish land tenure system-differing in relation to ownership, management, land use, land tenure, and size were evaluated. Twenty criteria were selected and classified into four groups: biophysical, social, economic and political. Finca Ledesma was the closest to the economic, social, environmental and political goals, according to the values and views of the actors involved in the decision. This study represented the first attempt to apply EA principles to forest restoration at landscape scale in the Yungas region. The benefits obtained by the application of the method were twofold: on one hand, researchers and local actors were forced to conceive the Yungas as a complex net of rights rather than as a sum of personal interests. On the other hand, the participatory multicriteria approach provided a structured process for collective decision-making in an area where it has never been implemented.

Applying the Ecosystem Approach to Select Priority Areas for Forest Landscape Restoration in the Yungas, Northwestern Argentina

NASA Astrophysics Data System (ADS)

Ianni, Elena; Geneletti, Davide

2010-11-01

This paper proposes a method to select forest restoration priority areas consistently with the key principles of the Ecosystem Approach (EA) and the Forest Landscape Restoration (FLR) framework. The methodology is based on the principles shared by the two approaches: acting at ecosystem scale, involving stakeholders, and evaluating alternatives. It proposes the involvement of social actors which have a stake in forest management through multicriteria analysis sessions aimed at identifying the most suitable forest restoration intervention. The method was applied to a study area in the native forests of Northern Argentina (the Yungas). Stakeholders were asked to identify alternative restoration actions, i.e. potential areas implementing FLR. Ten alternative fincas—estates derived from the Spanish land tenure system—differing in relation to ownership, management, land use, land tenure, and size were evaluated. Twenty criteria were selected and classified into four groups: biophysical, social, economic and political. Finca Ledesma was the closest to the economic, social, environmental and political goals, according to the values and views of the actors involved in the decision. This study represented the first attempt to apply EA principles to forest restoration at landscape scale in the Yungas region. The benefits obtained by the application of the method were twofold: on one hand, researchers and local actors were forced to conceive the Yungas as a complex net of rights rather than as a sum of personal interests. On the other hand, the participatory multicriteria approach provided a structured process for collective decision-making in an area where it has never been implemented.

Al embedded MgO barrier MTJ: A first principle study for application in fast and compact STT-MRAMs

NASA Astrophysics Data System (ADS)

Yadav, Manoj Kumar; Gupta, Santosh Kumar; Rai, Sanjeev; Pandey, Avinash C.

2017-03-01

The first principle comparative study of a novel single Al sheet embedded MgO and pure MgO barrier having Fe electrodes magnetic tunnel junction has been presented. Al embedded MgO is reported to provide enhanced spin polarised tunnelling current due to increase of spin-polarized density of states at Fermi energy in the barrier region. This novel MTJ provides a current density and resistance area (RA) product of 94.497 ×107 A / cm2 and 0.105  Ω - μm2 respectively. With such a low RA product; it allows higher deriving current due to which switching time of magnetization reversal reduces without inducing barrier related breakdowns in non-volatile magnetic random access memories. The low RA product and high current density of the proposed MTJ may have possible applications in integration with existing MOS circuits.

On representation of mechanical behavior and stereological measures of microstructure

NASA Technical Reports Server (NTRS)

Onat, E. T.; Wright, S. I.

1991-01-01

Macroscopic homogeneity of a heterogeneous body is defined from various points of view. The applicability of the principle of Delesse to a single macroscopically homogeneous body is discussed. It is then seen that a function derived from a consideration of the area fraction of a phase can serve as a measure of clustering of particles of that phase.

Application of Risk Management and Uncertainty Concepts and Methods for Ecosystem Restoration: Principles and Best Practice

DTIC Science & Technology

2012-08-01

habitats for specific species of trout . The report noted that these uncertainties — and the SMEs, who had past experience in such topic areas — were...reduce uncertainty in HREP projects is reflected in the completion of the Pool 11 Islands (UMRS RM 583-593) HREP in 2003. In 1989 the Browns Lake

Universal Design for Learning in the Classroom: Practical Applications. What Works for Special-Needs Learners Series

ERIC Educational Resources Information Center

Hall, Tracey E., Ed.; Meyer, Anne, Ed.; Rose, David H., Ed.

2012-01-01

Clearly written and well organized, this book shows how to apply the principles of universal design for learning (UDL) across all subject areas and grade levels. The editors and contributors describe practical ways to develop classroom goals, assessments, materials, and methods that use UDL to meet the needs of all learners. Specific teaching…

32 CFR 11.4 - Applicable principles of law.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false Applicable principles of law. 11.4 Section 11.4... ELEMENTS FOR TRIALS BY MILITARY COMMISSION § 11.4 Applicable principles of law. (a) General intent. All... wrongful if it is done without justification or excuse cognizable under applicable law. The element of...

Qualitative biomechanical principles for application in coaching.

PubMed

Knudson, Duane

2007-01-01

Many aspects of human movements in sport can be readily understood by Newtonian rigid-body mechanics. Many of these laws and biomechanical principles, however, are counterintuitive to a lot of people. There are also several problems in the application of biomechanics to sports, so the application of biomechanics in the qualitative analysis of sport skills by many coaches has been limited. Biomechanics scholars have long been interested in developing principles that facilitate the qualitative application of biomechanics to improve movement performance and reduce the risk of injury. This paper summarizes the major North American efforts to establish a set of general biomechanical principles of movement, and illustrates how principles can be used to improve the application of biomechanics in the qualitative analysis of sport technique. A coach helping a player with a tennis serve is presented as an example. The standardization of terminology for biomechanical principles is proposed as an important first step in improving the application ofbiomechanics in sport. There is also a need for international cooperation and research on the effectiveness of applying biomechanical principles in the coaching of sport techniques.

45 CFR 602.22 - Allowable costs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CFR part 31. Contract Cost Principles and Procedures, or uniform cost accounting standards that comply.... (b) Applicable cost principles. For each kind of organization, there is a set of Federal principles... principles applicable to the organization incurring the costs. The following chart lists the kinds of...

Evaluation of an employment program for people with mental illness using the Supported Employment Fidelity Scale.

PubMed

Cocks, Errol; Boaden, Ross

2009-10-01

The Individual Placement and Support (IPS) model aims to achieve open employment for people with mental illness. The Supported Employment Fidelity Scale (SEFS) is a 15-item instrument that evaluates the extent to which a service follows the IPS principles of best practice. This paper describes the IPS model and an evaluation of a specialist employment program for people with mental illness using the SEFS. The SEFS enabled a quantitative assessment of service provision against the criteria of evidence-based practice principles. Data were collected from multiple sources. In addition, a literature review was conducted, and personnel engaged in implementation of the IPS model at other Australian employment programs were consulted. The program achieved a score of 59 of a possible 75 on the SEFS, which is described as fair supported employment. Analysis of the 15-scale items resulted in the identification of strengths, areas for further development, and a set of recommendations. The program was operating substantially in line with evidence-based practice principles and had considerable scope for further development. Issues arising from the evaluation, areas of applicability of the SEFS and the underlying literature, and implications for occupational therapy are highlighted.

Molecular Assembly of Polysaccharide-Based Microcapsules and Their Biomedical Applications.

PubMed

Feng, Xiyun; Du, Cuiling; Li, Junbai

2016-08-01

Advanced multifunctional microcapsules have revealed great potential in biomedical applications owing to their tunable size, shape, surface properties, and stimuli responsiveness. Polysaccharides are one of the most acceptable biomaterials for biomedical applications because of their outstanding virtues such as biocompatibility, biodegradability, and low toxicity. Many efforts have been devoted to investigating novel molecular design and efficient building blocks for polysaccharide-based microcapsules. In this Personal Account, we first summarize the common features of polysaccharides and the main principles of the design and fabrication of polysaccharide-based microcapsules, and further discuss their applications in biomedical areas and perspectives for future research. © 2016 The Chemical Society of Japan & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Photoacoustic tomography and sensing in biomedicine

PubMed Central

Li, Changhui; Wang, Lihong V.

2010-01-01

Photoacoustics has been broadly studied in biomedicine, for both human and small animal tissues. Photoacoustics uniquely combines the absorption contrast of light or radio frequency waves with ultrasound resolution. Moreover, it is non-ionizing and non-invasive, and is the fastest growing new biomedical method, with clinical applications on the way. This article provides a brief review of recent developments in photoacoustics in biomedicine, from basic principles to applications. The emphasized areas include the new imaging modalities, hybrid detection methods, photoacoustic contrast agents, and the photoacoustic Doppler effect, as well as translational research topics. PMID:19724102

[Improving a hospital's supply chain through lean management].

PubMed

Aguilar-Escobar, V G; Garrido-Vega, P; Godino-Gallego, N

2013-01-01

Supply management is an area where hospitals have significant opportunities for improvement. The main objective of this paper has been to analyze how the application of Lean principles can improve logistics costs and user satisfaction. In connection with satisfaction, it also aimed to examine which aspects of the service define it and check for differences between different groups of users. The results of an experience to reorganize the hospital logistic system based on some Lean principles have been studied. This is therefore a case study, which combine different methods of data collection. The logistics cost calculation was carried out using the full costing method. To measure satisfaction of healthcare personnel, the internal logistics service users, an anonymous survey was conducted. Processing of the data obtained from the survey have included exploratory analysis, factor analysis and ANOVAs. The data have showed an improvement in logistics management after the implementation of Lean principles. Logistics costs were reduced and the satisfaction level of the internal users with the new logistics system was increased. Some differences in the degree of satisfaction by different groups of users were also detected, although they did not seem to distinguish between different aspects of logistic service. The analyzed experience shows the applicability and suitability of Lean principles to improve logistics operational costs and increase user satisfaction. Copyright © 2012 SECA. Published by Elsevier Espana. All rights reserved.

Policy on synthetic biology: deliberation, probability, and the precautionary paradox.

PubMed

Wareham, Christopher; Nardini, Cecilia

2015-02-01

Synthetic biology is a cutting-edge area of research that holds the promise of unprecedented health benefits. However, in tandem with these large prospective benefits, synthetic biology projects entail a risk of catastrophic consequences whose severity may exceed that of most ordinary human undertakings. This is due to the peculiar nature of synthetic biology as a 'threshold technology' which opens doors to opportunities and applications that are essentially unpredictable. Fears about these potentially unstoppable consequences have led to declarations from civil society groups calling for the use of a precautionary principle to regulate the field. Moreover, the principle is prevalent in law and international agreements. Despite widespread political recognition of a need for caution, the precautionary principle has been extensively criticized as a guide for regulatory policy. We examine a central objection to the principle: that its application entails crippling inaction and incoherence, since whatever action one takes there is always a chance that some highly improbable cataclysm will occur. In response to this difficulty, which we call the 'precautionary paradox,' we outline a deliberative means for arriving at threshold of probability below which potential dangers can be disregarded. In addition, we describe a Bayesian mechanism with which to assign probabilities to harmful outcomes. We argue that these steps resolve the paradox. The rehabilitated PP can thus provide a viable policy option to confront the uncharted waters of synthetic biology research. © 2013 John Wiley & Sons Ltd.

Dynamic sealing principles

NASA Technical Reports Server (NTRS)

Zuk, J.

1976-01-01

The fundamental principles governing dynamic sealing operation are discussed. Different seals are described in terms of these principles. Despite the large variety of detailed construction, there appear to be some basic principles, or combinations of basic principles, by which all seals function, these are presented and discussed. Theoretical and practical considerations in the application of these principles are discussed. Advantages, disadvantages, limitations, and application examples of various conventional and special seals are presented. Fundamental equations governing liquid and gas flows in thin film seals, which enable leakage calculations to be made, are also presented. Concept of flow functions, application of Reynolds lubrication equation, and nonlubrication equation flow, friction and wear; and seal lubrication regimes are explained.

Essential chemistry for biochemists

PubMed Central

Jonsson, Amanda L.; Roberts, Mark A.J.; Kiappes, J.L.; Scott, Kathryn A.

2017-01-01

Within every living organism, countless reactions occur every second. These reactions typically occur more rapidly and with greater efficiency than would be possible under the same conditions in the chemical laboratory, and while using only the subset of elements that are readily available in nature. Despite these apparent differences between life and the laboratory, biological reactions are governed by the same rules as any other chemical reaction. Thus, a firm understanding of the fundamentals of chemistry is invaluable in biochemistry. There are entire textbooks devoted to the application of chemical principles in biological systems and so it is not possible to cover all of the relevant topics in depth in this short article. The aim is instead to provide a brief overview of those areas in chemistry that are most relevant to biochemistry. We summarize the basic principles, give examples of how these principles are applied in biological systems and suggest further reading on individual topics. PMID:28951470

Elegant Shadow Making Tiny Force Visible for Water-Walking Arthropods and Updated Archimedes' Principle.

PubMed

Zheng, Yelong; Lu, Hongyu; Yin, Wei; Tao, Dashuai; Shi, Lichun; Tian, Yu

2016-10-07

Forces acted on legs of water-walking arthropods with weights in dynes are of great interest for entomologist, physicists, and engineers. While their floating mechanism has been recognized, the in vivo leg forces stationary have not yet been simultaneously achieved. In this study, their elegant bright-edged leg shadows are used to make the tiny forces visible and measurable based on the updated Archimedes' principle. The force was approximately proportional to the shadow area with a resolution from nanonewton to piconewton/pixel. The sum of leg forces agreed well with the body weight measured with an accurate electronic balance, which verified updated Archimedes' principle at the arthropod level. The slight changes of vertical body weight focus position and the body pitch angle have also been revealed for the first time. The visualization of tiny force by shadow is cost-effective and very sensitive and could be used in many other applications.

Robert Waelder and the application of psychoanalytic principles to social and political phenomena.

PubMed

Guttman, S A

1986-01-01

This presentation reveals a little-known area of Robert Waelder's work. As his literary executor, I have been privileged with access to his unpublished material, notes, and correspondence. And, of course, I am familiar with his mode of thinking. I wish to pass on some of this knowledge. What cannot be passed on, however, in some abstract intellectual way, are psychoanalytic principles themselves. Therefore, while this paper sheds light on a very particular aspect of Robert Waelder's work, it is also in some ways a cautionary tale, a plea that the reader understand what is behind the psychoanalytic point of view and its basic concepts--namely, clinical experience.

Strategic planning in Brazilian protected areas: Uses and adjustments.

PubMed

Barreto, Cristiane Gomes; Drummond, José Augusto L

2017-09-15

Management plans for protected areas commonly use strategic planning tools in their drafting. It is proposed that the adequate use of the instruments of planning and management of protected areas can improve their strategic competitiveness, providing greater financial and administrative independence, enabling them to be economically sustainable organizations. This study evaluated the application of concepts and strategy formulation, strategy principles and competitiveness, organizational diagnosis, strategic maps, scenarios, and other strategic planning instruments used for conservation management in Brazil. 25 management plans of 25 different protected areas were selected and studied, with special attention to the indicators used in each plan. Results indicate that there is a high suitability for the application of SP tools to the universe of protected areas, although management plans did not take full advantage of these tools. We also found that the broader use of these tools did not guarantee greater managerial effectiveness. We suggest that other governance variables beyond planning strategies must be improved, to ensure a better performance of protected areas. Copyright © 2017 Elsevier Ltd. All rights reserved.

Final Environmental Assessment for Aerial Spraying for Invasive Species Control MacDill AFB, Florida

DTIC Science & Technology

2007-09-01

bark tree (Melaleuca quinquinervia), Australian pine (Casuarina equisetifolia), Japanese mimosa (Albizia julibrissin) and, cogan grass (Imperata...inaccessible areas of the base. 2.1 DETAILED DESCRIPTION OF THE PROPOSED ACTION Invasive plant species such as Brazilian pepper, melaleuca, and mimosa are...principle invasive plant species proposed for treatment through the aerial application of herbicides include Brazilian pepper, melaleuca, and mimosa

29 CFR 780.138 - Application of the general principles.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 3 2010-07-01 2010-07-01 false Application of the general principles. 780.138 Section 780.138 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR... principles. Some examples will serve to illustrate the above principles. Employees of a fruit grower who dry...

Human error identification for laparoscopic surgery: Development of a motion economy perspective.

PubMed

Al-Hakim, Latif; Sevdalis, Nick; Maiping, Tanaphon; Watanachote, Damrongpan; Sengupta, Shomik; Dissaranan, Charuspong

2015-09-01

This study postulates that traditional human error identification techniques fail to consider motion economy principles and, accordingly, their applicability in operating theatres may be limited. This study addresses this gap in the literature with a dual aim. First, it identifies the principles of motion economy that suit the operative environment and second, it develops a new error mode taxonomy for human error identification techniques which recognises motion economy deficiencies affecting the performance of surgeons and predisposing them to errors. A total of 30 principles of motion economy were developed and categorised into five areas. A hierarchical task analysis was used to break down main tasks of a urological laparoscopic surgery (hand-assisted laparoscopic nephrectomy) to their elements and the new taxonomy was used to identify errors and their root causes resulting from violation of motion economy principles. The approach was prospectively tested in 12 observed laparoscopic surgeries performed by 5 experienced surgeons. A total of 86 errors were identified and linked to the motion economy deficiencies. Results indicate the developed methodology is promising. Our methodology allows error prevention in surgery and the developed set of motion economy principles could be useful for training surgeons on motion economy principles. Copyright © 2015 Elsevier Ltd and The Ergonomics Society. All rights reserved.

EDITORIAL: Imaging systems and techniques Imaging systems and techniques

NASA Astrophysics Data System (ADS)

Yang, Wuqiang; Giakos, George; Nikita, Konstantina; Pastorino, Matteo; Karras, Dimitrios

2009-10-01

The papers in this special issue focus on providing the state-of-the-art approaches and solutions to some of the most challenging imaging areas, such as the design, development, evaluation and applications of imaging systems, measuring techniques, image processing algorithms and instrumentation, with an ultimate aim of enhancing the measurement accuracy and image quality. This special issue explores the principles, engineering developments and applications of new imaging systems and techniques, and encourages broad discussion of imaging methodologies, shaping the future and identifying emerging trends. The multi-faceted field of imaging requires drastic adaptation to the rapid changes in our society, economy, environment and technological evolution. There is an urgent need to address new problems, which tend to be either static but complex, or dynamic, e.g. rapidly evolving with time, with many unknowns, and to propose innovative solutions. For instance, the battles against cancer and terror, monitoring of space resources and enhanced awareness, management of natural resources and environmental monitoring are some of the areas that need to be addressed. The complexity of the involved imaging scenarios and demanding design parameters, e.g. speed, signal-to-noise ratio (SNR), specificity, contrast, spatial resolution, scatter rejection, complex background and harsh environments, necessitate the development of a multi-functional, scalable and efficient imaging suite of sensors, solutions driven by innovation, and operation on diverse detection and imaging principles. Efficient medical imaging techniques capable of providing physiological information at the molecular level present another important research area. Advanced metabolic and functional imaging techniques, operating on multiple physical principles, and using high-resolution, high-selectivity nano-imaging methods, quantum dots, nanoparticles, biomarkers, nanostructures, nanosensors, micro-array imaging chips and nano-clinics for optical diagnostics and targeted therapy, can play an important role in the diagnosis and treatment of cancer. These techniques can also be used to provide efficient drug delivery for treatment of other diseases, with increased sensitivity and specificity. Similarly, enhanced stand-off detection, classification, identification and surveillance techniques, for comprehensive civilian and military target protection and enhanced space situational awareness can open new frontiers of research and applications in the defence arena and homeland security. For instance, the development of potential imaging sensor architectures, enhanced remote sensing systems, ladars, lidars and radars can provide data capable of ensuring continuous monitoring of various imaging/physical/chemical parameters under different operating conditions, using both active and passive detection principles, reconfigurable and scalable focal plane array architectures, reliable systems for stand-off detection of explosives, and enhanced airport security. The above areas pose challenging problems to the technical community and indicate an ever-growing need for innovative and auspicious solutions. We would like to thank all authors for their valuable contributions, without which this special issue would not have become reality.

Enhancing Food Processing by Pulsed and High Voltage Electric Fields: Principles and Applications.

PubMed

Wang, Qijun; Li, Yifei; Sun, Da-Wen; Zhu, Zhiwei

2018-02-02

Improvements in living standards result in a growing demand for food with high quality attributes including freshness, nutrition and safety. However, current industrial processing methods rely on traditional thermal and chemical methods, such as sterilization and solvent extraction, which could induce negative effects on food quality and safety. The electric fields (EFs) involving pulsed electric fields (PEFs) and high voltage electric fields (HVEFs) have been studied and developed for assisting and enhancing various food processes. In this review, the principles and applications of pulsed and high voltage electric fields are described in details for a range of food processes, including microbial inactivation, component extraction, and winemaking, thawing and drying, freezing and enzymatic inactivation. Moreover, the advantages and limitations of electric field related technologies are discussed to foresee future developments in the food industry. This review demonstrates that electric field technology has a great potential to enhance food processing by supplementing or replacing the conventional methods employed in different food manufacturing processes. Successful industrial applications of electric field treatments have been achieved in some areas such as microbial inactivation and extraction. However, investigations of HVEFs are still in an early stage and translating the technology into industrial applications need further research efforts.

An Ecological Approach to the Design of UAV Ground Control Station (GCS) Status Displays

NASA Technical Reports Server (NTRS)

Dowell, Susan; Morphew, Ephimia; Shively, Jay

2003-01-01

Use of UAVs in military and commercial applications will continue to increase. However, there has been limited research devoted to UAV GCS design. The current study employed an ecological approach to interfac e design. Ecological Interface Design (EID) can be characterized as r epresenting the properties of a system, such that an operator is enco uraged to use skill-based behavior when problem solving. When more ef fortful cognitive processes become necessary due to unfamiliar situations, the application of EID philosophy supports the application of kn owledge-based behavior. With advances toward multiple UAV command and control, operators need GCS interfaces designed to support understan ding of complex systems. We hypothesized that use of EID principles f or the display of UAV status information would result in better opera tor performance and situational awareness, while decreasing workload. Pilots flew a series of missions with three UAV GCS displays of statu s information (Alphanumeric, Ecological, and Hybrid display format). Measures of task performance, Situational Awareness, and workload dem onstrated the benefits of using an ecological approach to designing U AV GCS displays. The application of ecological principles to the design of UAV GCSs is a promising area for improving UAV operations.

Cost effective spectral sensor solutions for hand held and field applications

NASA Astrophysics Data System (ADS)

Reetz, Edgar; Correns, Martin; Notni, Gunther

2015-05-01

Optical spectroscopy is without doubt one of the most important non-contact measurement principles. It is used in a wide range of applications from bio-medical to industrial fields. One recent trend is to miniaturize spectral sensors to address new areas of application. The most common spectral sensor type is based on diffraction gratings, while other types are based on micro mechanical systems (MEMS) or filter technologies. The authors represent the opinion that there is a potentially wide spread field of applications for spectrometers, but the market limits the range of applications since they cannot keep up with targeted cost requirements for consumer products. The present article explains an alternative approach for miniature multichannel spectrometer to enhance robustness for hand held field applications at a cost efficient price point.

Precaution or Integrated Responsibility Approach to Nanovaccines in Fish Farming? A Critical Appraisal of the UNESCO Precautionary Principle.

PubMed

Myhr, Anne Ingeborg; Myskja, Bjørn K

2011-04-01

Nanoparticles have multifaceted advantages in drug administration as vaccine delivery and hence hold promises for improving protection of farmed fish against diseases caused by pathogens. However, there are concerns that the benefits associated with distribution of nanoparticles may also be accompanied with risks to the environment and health. The complexity of the natural and social systems involved implies that the information acquired in quantified risk assessments may be inadequate for evidence-based decisions. One controversial strategy for dealing with this kind of uncertainty is the precautionary principle. A few years ago, an UNESCO expert group suggested a new approach for implementation of the principle. Here we compare the UNESCO principle with earlier versions and explore the advantages and disadvantages by employing the UNESCO version to the use of PLGA nanoparticles for delivery of vaccines in aquaculture. Finally, we discuss whether a combined scientific and ethical analysis that involves the concept of responsibility will enable approaches that can provide a supplement to the precautionary principle as basis for decision-making in areas of scientific uncertainty, such as the application of nanoparticles in the vaccination of farmed fish.

Pharmaceutical product development: A quality by design approach

PubMed Central

Pramod, Kannissery; Tahir, M. Abu; Charoo, Naseem A.; Ansari, Shahid H.; Ali, Javed

2016-01-01

The application of quality by design (QbD) in pharmaceutical product development is now a thrust area for the regulatory authorities and the pharmaceutical industry. International Conference on Harmonization and United States Food and Drug Administration (USFDA) emphasized the principles and applications of QbD in pharmaceutical development in their guidance for the industry. QbD attributes are addressed in question-based review, developed by USFDA for chemistry, manufacturing, and controls section of abbreviated new drug applications. QbD principles, when implemented, lead to a successful product development, subsequent prompt regulatory approval, reduce exhaustive validation burden, and significantly reduce post-approval changes. The key elements of QbD viz., target product quality profile, critical quality attributes, risk assessments, design space, control strategy, product lifecycle management, and continual improvement are discussed to understand the performance of dosage forms within design space. Design of experiments, risk assessment tools, and process analytical technology are also discussed for their role in QbD. This review underlines the importance of QbD in inculcating science-based approach in pharmaceutical product development. PMID:27606256

Pharmaceutical product development: A quality by design approach.

PubMed

Pramod, Kannissery; Tahir, M Abu; Charoo, Naseem A; Ansari, Shahid H; Ali, Javed

2016-01-01

The application of quality by design (QbD) in pharmaceutical product development is now a thrust area for the regulatory authorities and the pharmaceutical industry. International Conference on Harmonization and United States Food and Drug Administration (USFDA) emphasized the principles and applications of QbD in pharmaceutical development in their guidance for the industry. QbD attributes are addressed in question-based review, developed by USFDA for chemistry, manufacturing, and controls section of abbreviated new drug applications. QbD principles, when implemented, lead to a successful product development, subsequent prompt regulatory approval, reduce exhaustive validation burden, and significantly reduce post-approval changes. The key elements of QbD viz., target product quality profile, critical quality attributes, risk assessments, design space, control strategy, product lifecycle management, and continual improvement are discussed to understand the performance of dosage forms within design space. Design of experiments, risk assessment tools, and process analytical technology are also discussed for their role in QbD. This review underlines the importance of QbD in inculcating science-based approach in pharmaceutical product development.

29 CFR 1620.19 - Equality of wages-application of the principle.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 4 2010-07-01 2010-07-01 false Equality of wages-application of the principle. 1620.19 Section 1620.19 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION THE EQUAL PAY ACT § 1620.19 Equality of wages—application of the principle. Equal wages must be paid...

12 CFR 745.2 - General principles applicable in determining insurance of accounts.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 6 2010-01-01 2010-01-01 false General principles applicable in determining... Insurance Coverage § 745.2 General principles applicable in determining insurance of accounts. (a) General... law enters into a share insurance determination, the local law of the jurisdiction in which the...

A descriptive and historical review of bibliometrics with applications to medical sciences.

PubMed

Thompson, Dennis F; Walker, Cheri K

2015-06-01

The discipline of bibliometrics involves the application of mathematical and statistical methods to scholarly publications. The first attempts at systematic data collection were provided by Alfred Lotka and Samuel Bradford, who subsequently established the foundational laws of bibliometrics. Eugene Garfield ushered in the modern era of bibliometrics with the routine use of citation analysis and systematized processing. Key elements of bibliometric analysis include database coverage, consistency and accuracy of the data, data fields, search options, and analysis and use of metrics. A number of bibliometric applications are currently being used in medical science and health care. Bibliometric parameters and indexes may be increasingly used by grant funding sources as measures of research success. Universities may build benchmarking standards from bibliometric data to determine academic achievement through promotion and tenure guidelines in the future. This article reviews the history, definition, laws, and elements of bibliometric principles and provides examples of bibliometric applications to the broader health care community. To accomplish this, the Medline (1966-2014) and Web of Science (1945-2014) databases were searched to identify relevant articles; select articles were also cross-referenced. Articles selected were those that provided background, history, descriptive analysis, and application of bibliometric principles and metrics to medical science and health care. No attempt was made to cover all areas exhaustively; rather, key articles were chosen that illustrate bibliometric concepts and enhance the reader's knowledge. It is important that faculty and researchers understand the limitations and appropriate uses of bibliometric data. Bibliometrics has considerable potential as a research area for health care scientists and practitioners that can be used to discover new information about academic trends, pharmacotherapy, disease, and broader health sciences trends. © 2015 Pharmacotherapy Publications, Inc.

Ecosystem Based Management in Transition: From Ocean Policy to Application

NASA Astrophysics Data System (ADS)

Saumweber, W. J.; Goldman, E.

2016-02-01

Ecosystem-based management (EBM) has been proposed as a means to improve resource management and stewardship for more than two decades. Over this history, its exact goals and approaches have evolved in concert with advances in science and policy, including a greater understanding of ecosystem function, valuation, and thresholds for change, along with direct reference to EBM principles in statute, regulation, and other Executive Actions. Most recently, and explicitly, the Administration's National Ocean Policy (NOP) called for the development of a Federal EBM framework that would outline principles and guidelines for implementing EBM under existing authorities. This cross-agency framework has yet to be developed, but, the NOP, and related Administration initiatives, have resulted in the practical application of EBM principles in several issue-specific policy initiatives ranging from fisheries and marine protected area management to coastal adaptation and water resource infrastructure investment. In each case, the application of EBM principles uses apparently unique policy mechanisms (e.g. marine planning, ecosystem services assessment, adaptive management, dynamic ocean management, etc.). Despite differences in terminology and policy context, each of these policy initiatives is linked at its core to concepts of integrated and adaptive management that consider broad ecosystem function and services. This practical history of EBM implementation speaks to both the challenges and opportunities in broad incorporation of EBM across diverse policy initiatives and frameworks. We suggest that the continued growth of EBM as a practical policy concept will require a move away from broad frameworks, and towards the identification of specific resource management issues and accompanying policy levers with which to address those issues. In order to promote this progression, Federal policy should recognize and articulate the diverse set of policy mechanisms encompassed under the rubric of EBM and seek to require similar approaches across the spectra of resource management issues.

Ecosystem Based Management in Transition: From Ocean Policy to Application

NASA Astrophysics Data System (ADS)

Saumweber, W. J.; Goldman, E.

2016-12-01

Ecosystem-based management (EBM) has been proposed as a means to improve resource management and stewardship for more than two decades. Over this history, its exact goals and approaches have evolved in concert with advances in science and policy, including a greater understanding of ecosystem function, valuation, and thresholds for change, along with direct reference to EBM principles in statute, regulation, and other Executive Actions. Most recently, and explicitly, the Administration's National Ocean Policy (NOP) called for the development of a Federal EBM framework that would outline principles and guidelines for implementing EBM under existing authorities. This cross-agency framework has yet to be developed, but, the NOP, and related Administration initiatives, have resulted in the practical application of EBM principles in several issue-specific policy initiatives ranging from fisheries and marine protected area management to coastal adaptation and water resource infrastructure investment. In each case, the application of EBM principles uses apparently unique policy mechanisms (e.g. marine planning, ecosystem services assessment, adaptive management, dynamic ocean management, etc.). Despite differences in terminology and policy context, each of these policy initiatives is linked at its core to concepts of integrated and adaptive management that consider broad ecosystem function and services. This practical history of EBM implementation speaks to both the challenges and opportunities in broad incorporation of EBM across diverse policy initiatives and frameworks. We suggest that the continued growth of EBM as a practical policy concept will require a move away from broad frameworks, and towards the identification of specific resource management issues and accompanying policy levers with which to address those issues. In order to promote this progression, Federal policy should recognize and articulate the diverse set of policy mechanisms encompassed under the rubric of EBM and seek to require similar approaches across the spectra of resource management issues.

28 CFR 552.22 - Principles governing the use of force and application of restraints.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Principles governing the use of force and... JUSTICE INSTITUTIONAL MANAGEMENT CUSTODY Use of Force and Application of Restraints on Inmates § 552.22 Principles governing the use of force and application of restraints. (a) Staff ordinarily shall first attempt...

Why Is It Taking So Long for Behavior Modification To Be Used in the Schools, or, Am I Being Too Impatient?

ERIC Educational Resources Information Center

Pumroy, Donald K.

In education, as in the area of mental illness, the first application of behavior modification began with the treatment of the severely retarded and the autistic. By 1970 behavioral principles were being applied to normal children in the home and regular classes in schools. While behavior modification has been accepted to some degree in special…

A pharmacy business management simulation exercise as a practical application of business management material and principles.

PubMed

Rollins, Brent L; Gunturi, Rahul; Sullivan, Donald

2014-04-17

To implement a pharmacy business management simulation exercise as a practical application of business management material and principles and assess students' perceived value. As part of a pharmacy management and administration course, students made various calculations and management decisions in the global categories of hours of operation, inventory, pricing, and personnel. The students entered the data into simulation software and a realistic community pharmacy marketplace was modeled. Course topics included accounting, economics, finance, human resources, management, marketing, and leadership. An 18-item posttest survey was administered. Students' slightly to moderately agreed the pharmacy simulation program enhanced their knowledge and understanding, particularly of inventory management, cash flow statements, balance sheets, and income statements. Overall attitudes toward the pharmacy simulation program were also slightly positive and students also slightly agreed the pharmacy simulation program enhanced their learning of pharmacy business management. Inventory management was the only area in which students felt they had at least "some" exposure to the assessed business management topics during IPPEs/internship, while all other areas of experience ranged from "not at all" to "a little." The pharmacy simulation program is an effective active-learning exercise and enhanced students' knowledge and understanding of the business management topics covered.

A Pharmacy Business Management Simulation Exercise as a Practical Application of Business Management Material and Principles

PubMed Central

Rollins, Brent L.; Gunturi, Rahul; Sullivan, Donald

2014-01-01

Objective. To implement a pharmacy business management simulation exercise as a practical application of business management material and principles and assess students’ perceived value. Design. As part of a pharmacy management and administration course, students made various calculations and management decisions in the global categories of hours of operation, inventory, pricing, and personnel. The students entered the data into simulation software and a realistic community pharmacy marketplace was modeled. Course topics included accounting, economics, finance, human resources, management, marketing, and leadership. Assessment. An 18-item posttest survey was administered. Students’ slightly to moderately agreed the pharmacy simulation program enhanced their knowledge and understanding, particularly of inventory management, cash flow statements, balance sheets, and income statements. Overall attitudes toward the pharmacy simulation program were also slightly positive and students also slightly agreed the pharmacy simulation program enhanced their learning of pharmacy business management. Inventory management was the only area in which students felt they had at least “some” exposure to the assessed business management topics during IPPEs/internship, while all other areas of experience ranged from “not at all” to “a little.” Conclusion. The pharmacy simulation program is an effective active-learning exercise and enhanced students’ knowledge and understanding of the business management topics covered. PMID:24761023

Automatic detection of measurement points for non-contact vibrometer-based diagnosis of cardiac arrhythmias

NASA Astrophysics Data System (ADS)

Metzler, Jürgen; Kroschel, Kristian; Willersinn, Dieter

2017-03-01

Monitoring of the heart rhythm is the cornerstone of the diagnosis of cardiac arrhythmias. It is done by means of electrocardiography which relies on electrodes attached to the skin of the patient. We present a new system approach based on the so-called vibrocardiogram that allows an automatic non-contact registration of the heart rhythm. Because of the contactless principle, the technique offers potential application advantages in medical fields like emergency medicine (burn patient) or premature baby care where adhesive electrodes are not easily applicable. A laser-based, mobile, contactless vibrometer for on-site diagnostics that works with the principle of laser Doppler vibrometry allows the acquisition of vital functions in form of a vibrocardiogram. Preliminary clinical studies at the Klinikum Karlsruhe have shown that the region around the carotid artery and the chest region are appropriate therefore. However, the challenge is to find a suitable measurement point in these parts of the body that differs from person to person due to e. g. physiological properties of the skin. Therefore, we propose a new Microsoft Kinect-based approach. When a suitable measurement area on the appropriate parts of the body are detected by processing the Kinect data, the vibrometer is automatically aligned on an initial location within this area. Then, vibrocardiograms on different locations within this area are successively acquired until a sufficient measuring quality is achieved. This optimal location is found by exploiting the autocorrelation function.

Investigation of air transportation technology at Princeton University, 1984

NASA Technical Reports Server (NTRS)

Stengel, Robert F.

1987-01-01

The Air Transportation Technology Program at Princeton University, a program emphasizing graduate and undergraduate student research, proceeded along four avenues during 1984: (1) guidance and control strategies for penetration of microbursts and wind shear; (2) application of artificial intelligence in flight control systems; (3) effects of control saturation on closed loop stability; and (4) response of open loop unstable aircraft. Areas of investigation relate to guidance and control of commercial transports as well as to general aviation aircraft. Interaction between the flight crew and automatic systems is a subject of principle concern. These areas of investigation are briefly discussed.

Quality circles and their potential application to rural health care in Papua New Guinea.

PubMed

Cibulskis, R E; Edwards, K N

1993-06-01

A quality circle is a group of service providers who meet regularly to solve problems relating to the quality of their work. This is an example of bottom-up rather than top-down management which has found considerable success in the industries of the developed world. This article describes the principles which govern the operation of quality circles, the expected benefits and how best to introduce them. The problems relating to the provision of quality health care in rural areas and the potential application of the quality circle methodology are discussed.

19 CFR 10.550 - Verification and justification of claim for preferential treatment.

Code of Federal Regulations, 2010 CFR

2010-04-01

... may agree. (b) Applicable accounting principles. When conducting a verification of origin to which Generally Accepted Accounting Principles may be relevant, CBP will apply and accept the Generally Accepted Accounting Principles applicable in the country of production. ...

Application of First Principles Ni-Cd and Ni-H2 Battery Models to Spacecraft Operations

NASA Technical Reports Server (NTRS)

Timmerman, Paul; Bugga, Ratnakumar; DiStefano, Salvador

1997-01-01

The conclusions of the application of first principles model to spacecraft operations are: the first principles of Bi-phasic electrode presented model provides an explanation for many behaviors on voltage fading on LEO cycling.

Computer validation in toxicology: historical review for FDA and EPA good laboratory practice.

PubMed

Brodish, D L

1998-01-01

The application of computer validation principles to Good Laboratory Practice is a fairly recent phenomenon. As automated data collection systems have become more common in toxicology facilities, the U.S. Food and Drug Administration and the U.S. Environmental Protection Agency have begun to focus inspections in this area. This historical review documents the development of regulatory guidance on computer validation in toxicology over the past several decades. An overview of the components of a computer life cycle is presented, including the development of systems descriptions, validation plans, validation testing, system maintenance, SOPs, change control, security considerations, and system retirement. Examples are provided for implementation of computer validation principles on laboratory computer systems in a toxicology facility.

Rotation Flaps-Principles and Locations.

PubMed

LoPiccolo, Matteo C

2015-10-01

The rotation flap is a classic method of tissue rearrangement. It is a simple yet effective tool for recruiting tissue from areas of laxity and redirecting vectors of tension to reconstruct wounds not amenable to primary closure. This article presents the basic design principles and specific applications of the rotation flap in dermatologic surgery. A Medline search of articles describing rotation flaps published prior to April 1, 2015 was performed, and several prominent texts in dermatologic surgery were reviewed. Information gathered from the above sources is combined with the clinical experience of the author and editors to present surgeons with a guide for planning and executing various rotation flaps. Mastering the technique of the rotation flap will allow a surgeon to repair a wide variety of cutaneous defects.

How medical ethical principles are applied in treatment with artificial insemination by donors (AID) in Hunan, China: effective practice at the Reproductive and Genetic Hospital of CITIC-Xiangya

PubMed Central

Li, L; Lu, G

2005-01-01

This paper investigates the efficiency of application of medical ethics principles in the practice of artificial insemination by donors (AID) in China, in a culture characterised by traditional ethical values and disapproval of AID. The paper presents the ethical approach to AID treatment as established by the Reproduction and Genetics Hospital of CITIC-Xiangya (CITIC Hunan-Yale Approach) in the central southern area of China against the social ethical background of China and describes its general features. The CITIC-Xiangya Approach facilitates the implementation of ethical relations between clinicians and patients participating in AID treatment procedures in Hunan-Yale. PMID:15923480

The Development of a Degree 360 Expansion of the Dynamic Ocean Topography of the POCM_4B Global Circulation Model

NASA Technical Reports Server (NTRS)

Rapp, Richard H.

1998-01-01

This paper documents the development of a degree 360 expansion of the dynamic ocean topography (DOT) of the POCM_4B ocean circulation model. The principles and software used that led to the final model are described. A key principle was the development of interpolated DOT values into land areas to avoid discontinuities at or near the land/ocean interface. The power spectrum of the POCM_4B is also presented with comparisons made between orthonormal (ON) and spherical harmonic magnitudes to degree 24. A merged file of ON and SH computed degree variances is proposed for applications where the DOT power spectrum from low to high (360) degrees is needed.

Mathematical Modeling of Extinction of Inhomogeneous Populations

PubMed Central

Karev, G.P.; Kareva, I.

2016-01-01

Mathematical models of population extinction have a variety of applications in such areas as ecology, paleontology and conservation biology. Here we propose and investigate two types of sub-exponential models of population extinction. Unlike the more traditional exponential models, the life duration of sub-exponential models is finite. In the first model, the population is assumed to be composed clones that are independent from each other. In the second model, we assume that the size of the population as a whole decreases according to the sub-exponential equation. We then investigate the “unobserved heterogeneity”, i.e. the underlying inhomogeneous population model, and calculate the distribution of frequencies of clones for both models. We show that the dynamics of frequencies in the first model is governed by the principle of minimum of Tsallis information loss. In the second model, the notion of “internal population time” is proposed; with respect to the internal time, the dynamics of frequencies is governed by the principle of minimum of Shannon information loss. The results of this analysis show that the principle of minimum of information loss is the underlying law for the evolution of a broad class of models of population extinction. Finally, we propose a possible application of this modeling framework to mechanisms underlying time perception. PMID:27090117

On the Pontryagin maximum principle for systems with delays. Economic applications

NASA Astrophysics Data System (ADS)

Kim, A. V.; Kormyshev, V. M.; Kwon, O. B.; Mukhametshin, E. R.

2017-11-01

The Pontryagin maximum principle [6] is the key stone of finite-dimensional optimal control theory [1, 2, 5]. So beginning with opening the maximum principle it was important to extend the maximum principle on various classes of dynamical systems. In t he paper we consider some aspects of application of i-smooth analysis [3, 4] in the theory of the Pontryagin maximum principle [6] for systems with delays, obtained results can be applied by elaborating optimal program controls in economic models with delays.

Precision optical device of freeform defects inspection

NASA Astrophysics Data System (ADS)

Meguellati, S.

2015-09-01

This method of optical scanning presented in this paper is used for precision measurement deformation in shape or absolute forms in comparison with a reference component form, of optical or mechanical components, on reduced surfaces area that are of the order of some mm2 and more. The principle of the method is to project the image of the source grating to palpate optically surface to be inspected, after reflection; the image of the source grating is printed by the object topography and is then projected onto the plane of reference grating for generate moiré fringe for defects detection. The optical device used allows a significant dimensional surface magnification of up to 1000 times the area inspected for micro-surfaces, which allows easy processing and reaches an exceptional nanometric imprecision of measurements. According to the measurement principle, the sensitivity for displacement measurement using moiré technique depends on the frequency grating, for increase the detection resolution. This measurement technique can be used advantageously to measure the deformations generated by the production process or constraints on functional parts and the influence of these variations on the function. The optical device and optical principle, on which it is based, can be used for automated inspection of industrially produced goods. It can also be used for dimensional control when, for example, to quantify the error as to whether a piece is good or rubbish. It then suffices to compare a figure of moiré fringes with another previously recorded from a piece considered standard; which saves time, money and accuracy. The technique has found various applications in diverse fields, from biomedical to industrial and scientific applications.

Technical principles of direct bipolar electrostimulation for cortical and subcortical mapping in awake craniotomy.

PubMed

Pallud, J; Mandonnet, E; Corns, R; Dezamis, E; Parraga, E; Zanello, M; Spena, G

2017-06-01

Intraoperative application of electrical current to the brain is a standard technique during brain surgery for inferring the function of the underlying brain. The purpose of intraoperative functional mapping is to reliably identify cortical areas and subcortical pathways involved in eloquent functions, especially motor, sensory, language and cognitive functions. The aim of this article is to review the rationale and the electrophysiological principles of the use of direct bipolar electrostimulation for cortical and subcortical mapping under awake conditions. Direct electrical stimulation is a window into the whole functional network that sustains a particular function. It is an accurate (spatial resolution of about 5mm) and a reproducible technique particularly adapted to clinical practice for brain resection in eloquent areas. If the procedure is rigorously applied, the sensitivity of direct electrical stimulation for the detection of cortical and subcortical eloquent areas is nearly 100%. The main disadvantage of this technique is its suboptimal specificity. Another limitation is the identification of eloquent areas during surgery, which, however, could have been functionally compensated postoperatively if removed surgically. Direct electrical stimulation is an easy, accurate, reliable and safe invasive technique for the intraoperative detection of both cortical and subcortical functional brain connectivity for clinical purpose. In our opinion, it is the optimal technique for minimizing the risk of neurological sequelae when resecting in eloquent brain areas. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Commercial Vessel Safety. Economic Costs. Preliminary.

DTIC Science & Technology

1979-12-01

or "rippled" through the economy when a regulation is implemented. The survey associated with determination of costs focused upon two basic areas...in their application of standard financial principles and in their utilization of basic ship cost components (e.g., investment and operating costs...on the estimation of costs per ton of capacity provided. The basic unit for analyzing ships’ costs used is a single voyage (round trip) on a particular

Judo principles and practices: applications to conflict-solving strategies in psychotherapy.

PubMed

Gleser, J; Brown, P

1988-07-01

Jigoro Kano created judo from ju-jitsu techniques. He realized that the Ju principle of both judo and ju-jitsu as the art of yielding, was that of living and changing. The principle of yielding has been applied in dynamic and directive psychotherapies for many years and was recently linked to the Ju principle in martial arts. After several years of using a modified judo practice as a therapeutic tool, and applying the principle of yielding as a dynamic conflict-solving strategy, the authors discovered judo principles applicable to conflict solving, particularly for regressed and violent psychotic patients.

Use of computers in dysmorphology.

PubMed Central

Diliberti, J H

1988-01-01

As a consequence of the increasing power and decreasing cost of digital computers, dysmorphologists have begun to explore a wide variety of computerised applications in clinical genetics. Of considerable interest are developments in the areas of syndrome databases, expert systems, literature searches, image processing, and pattern recognition. Each of these areas is reviewed from the perspective of the underlying computer principles, existing applications, and the potential for future developments. Particular emphasis is placed on the analysis of the tasks performed by the dysmorphologist and the design of appropriate tools to facilitate these tasks. In this context the computer and associated software are considered paradigmatically as tools for the dysmorphologist and should be designed accordingly. Continuing improvements in the ability of computers to manipulate vast amounts of data rapidly makes the development of increasingly powerful tools for the dysmorphologist highly probable. PMID:3050092

17 CFR 49.19 - Core principles applicable to registered swap data repositories.

Code of Federal Regulations, 2014 CFR

2014-04-01

... registered swap data repositories. 49.19 Section 49.19 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION (CONTINUED) SWAP DATA REPOSITORIES § 49.19 Core principles applicable to registered swap data repositories. (a) Compliance with core principles. To be registered, and maintain...

One common way - The strategic and methodological influence on environmental planning across Europe

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jiricka, Alexandra, E-mail: alexandra.jiricka@boku.ac.a; Proebstl, Ulrike, E-mail: ulrike.proebstl@boku.ac.a

In the last decades the European Union exerted influence on precautionary environmental planning by the establishment of several Directives. The most relevant were the Habitat-Directive, the EIA-Directive, the SEA-Directive and the Water Framework Directive. Comparing these EU policies in the area of environmental precaution it becomes obvious that there is a lot of common ground. Thus, the conclusion seems likely that the European Union, in doing so, has intended to establish general planning concepts through introducing several methodological steps indicated by the regulations. The goal of this article is firstly to point out, which are the common planning principles, convertedmore » by methodological elements and secondly examine the consideration of these planning concepts by the implementation and application in the member states. In this context it is analysed whether the connections and divergences between the directives lead to significant differences in the implementation process. To this aim the directives are shortly introduced and significant steps of the processes regulated by them are outlined. In the second steps the national legal implementation in the Alpine states and its consequences for the practical application are discussed. The results show a heterogeneous application of the EU principles. Within the comparative view on the four directives influence and causalities between the national implementation and the practical application were identified, which can be simplified as four types. Since a coherent strategic and methodological concept for improving environmental precaution planning from part of the EU is noticeable, more unity and comparability within the implementation is desirable, particularly in areas with comparable habitats such as the alpine space. Beyond this the trade-off between the directives poses an important task for the future.« less

Twelve Principles for Green Energy Storage in Grid Applications.

PubMed

Arbabzadeh, Maryam; Johnson, Jeremiah X; Keoleian, Gregory A; Rasmussen, Paul G; Thompson, Levi T

2016-01-19

The introduction of energy storage technologies to the grid could enable greater integration of renewables, improve system resilience and reliability, and offer cost effective alternatives to transmission and distribution upgrades. The integration of energy storage systems into the electrical grid can lead to different environmental outcomes based on the grid application, the existing generation mix, and the demand. Given this complexity, a framework is needed to systematically inform design and technology selection about the environmental impacts that emerge when considering energy storage options to improve sustainability performance of the grid. To achieve this, 12 fundamental principles specific to the design and grid application of energy storage systems are developed to inform policy makers, designers, and operators. The principles are grouped into three categories: (1) system integration for grid applications, (2) the maintenance and operation of energy storage, and (3) the design of energy storage systems. We illustrate the application of each principle through examples published in the academic literature, illustrative calculations, and a case study with an off-grid application of vanadium redox flow batteries (VRFBs). In addition, trade-offs that can emerge between principles are highlighted.

The great opportunity: Evolutionary applications to medicine and public health.

PubMed

Nesse, Randolph M; Stearns, Stephen C

2008-02-01

Evolutionary biology is an essential basic science for medicine, but few doctors and medical researchers are familiar with its most relevant principles. Most medical schools have geneticists who understand evolution, but few have even one evolutionary biologist to suggest other possible applications. The canyon between evolutionary biology and medicine is wide. The question is whether they offer each other enough to make bridge building worthwhile. What benefits could be expected if evolution were brought fully to bear on the problems of medicine? How would studying medical problems advance evolutionary research? Do doctors need to learn evolution, or is it valuable mainly for researchers? What practical steps will promote the application of evolutionary biology in the areas of medicine where it offers the most? To address these questions, we review current and potential applications of evolutionary biology to medicine and public health. Some evolutionary technologies, such as population genetics, serial transfer production of live vaccines, and phylogenetic analysis, have been widely applied. Other areas, such as infectious disease and aging research, illustrate the dramatic recent progress made possible by evolutionary insights. In still other areas, such as epidemiology, psychiatry, and understanding the regulation of bodily defenses, applying evolutionary principles remains an open opportunity. In addition to the utility of specific applications, an evolutionary perspective fundamentally challenges the prevalent but fundamentally incorrect metaphor of the body as a machine designed by an engineer. Bodies are vulnerable to disease - and remarkably resilient - precisely because they are not machines built from a plan. They are, instead, bundles of compromises shaped by natural selection in small increments to maximize reproduction, not health. Understanding the body as a product of natural selection, not design, offers new research questions and a framework for making medical education more coherent. We conclude with recommendations for actions that would better connect evolutionary biology and medicine in ways that will benefit public health. It is our hope that faculty and students will send this article to their undergraduate and medical school Deans, and that this will initiate discussions about the gap, the great opportunity, and action plans to bring the full power of evolutionary biology to bear on human health problems.

Introduction to polymer-based solid-contact ion-selective electrodes-basic concepts, practical considerations, and current research topics.

PubMed

Bieg, Christoph; Fuchsberger, Kai; Stelzle, Martin

2017-01-01

This review aims at providing an introductory overview for researchers new to the field of ion-selective electrodes. Both state of the art technology and novel developments towards solid-contact reference (sc-RE) and solid-contact ion selective electrodes (sc-ISE) are discussed. This technology has potentially widespread and important applications provided certain performance criteria can be met. We present basic concepts, operation principles, and theoretical considerations with regard to their function. Analytical performance and suitability of sc-RE and sc-ISE for a given application depend on critical parameters, which are discussed in this review. Comprehensive evaluation of sensor performance along this set of parameters is considered indispensable to allow for a well-founded comparison of different technologies. Methods and materials employed in the construction of sc-RE and sc-ISE, in particular the solid contact and the polymer membrane composite, are presented and discussed in detail. Operation principles beyond potentiometry are mentioned, which would further extend the field of ISE application. Finally, we conclude by directing the reader to important areas for further scientific research and development work considered particularly critical and promising for advancing this field in sensor R&D. Graphical Abstract ᅟ.

Chronology of Fabry-Perot Interferometer Fiber-Optic Sensors and Their Applications: A Review

PubMed Central

Islam, Md. Rajibul; Ali, Muhammad Mahmood; Lai, Man-Hong; Lim, Kok-Sing; Ahmad, Harith

2014-01-01

Optical fibers have been involved in the area of sensing applications for more than four decades. Moreover, interferometric optical fiber sensors have attracted broad interest for their prospective applications in sensing temperature, refractive index, strain measurement, pressure, acoustic wave, vibration, magnetic field, and voltage. During this time, numerous types of interferometers have been developed such as Fabry-Perot, Michelson, Mach-Zehnder, Sagnac Fiber, and Common-path interferometers. Fabry-Perot interferometer (FPI) fiber-optic sensors have been extensively investigated for their exceedingly effective, simple fabrication as well as low cost aspects. In this study, a wide variety of FPI sensors are reviewed in terms of fabrication methods, principle of operation and their sensing applications. The chronology of the development of FPI sensors and their implementation in various applications are discussed. PMID:24763250

State-of-the-art review of the applications of nanotechnology in pavement materials

NASA Astrophysics Data System (ADS)

Castillo, Luis, Jr.

The use of nanotechnology in pavement materials is one main area that shows great promise and has the potential to change commonly used materials. This will develop more effective solutions to achieve the desired performance. The overall objective of this work is to present a state-of-the-art literature review of nano-science-based principles to improve the performance and, ultimately, the life cycle of transportation construction materials. This work will be organized into two different parts. The first part will consist of six sections: applications of nanotechnology in concrete pavements, applications of nanotechnology in asphalt pavement, application of nanotechnology in general soils, cost-benefit analysis, challenges, and trends to the future. In addition, a current practice review was performed from a literature review that included a questionnaire of the knowledge and opinion about nanotechnology, which included students, general contractors, teachers, engineers, and architects. The second part will deal with the advancement of the application of nanotechnology in pavement materials for different developed countries. Because nanotechnology is relatively a young field in pavement materials, limited research has been conducted in North America, Europe, and Asia. A comparison of the advancement of nano-science-based principles, as applied to the performance and life cycle of transportation materials, for the three continents will be carried out in a summarized manner.

Lighting in Schools.

ERIC Educational Resources Information Center

Department of Education and Science, London (England).

The application of good lighting principles to school design is discussed. Part 1 of the study is concerned with the general principles of light and vision as they affect lighting in schools. Parts 2 and 3 deal with the application of these principles to daylighting and artificial lighting. Part 4 discusses the circumstances in which the…

17 CFR 49.19 - Core principles applicable to registered swap data repositories.

Code of Federal Regulations, 2013 CFR

2013-04-01

... registered swap data repositories. 49.19 Section 49.19 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION SWAP DATA REPOSITORIES § 49.19 Core principles applicable to registered swap data repositories. (a) Compliance with core principles. To be registered, and maintain registration, a swap data...

17 CFR 49.19 - Core principles applicable to registered swap data repositories.

Code of Federal Regulations, 2012 CFR

2012-04-01

... registered swap data repositories. 49.19 Section 49.19 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION SWAP DATA REPOSITORIES § 49.19 Core principles applicable to registered swap data repositories. (a) Compliance with Core Principles. To be registered, and maintain registration, a swap data...

Note: application of a pixel-array area detector to simultaneous single crystal X-ray diffraction and X-ray absorption spectroscopy measurements.

PubMed

Sun, Cheng-Jun; Zhang, Bangmin; Brewe, Dale L; Chen, Jing-Sheng; Chow, G M; Venkatesan, T; Heald, Steve M

2014-04-01

X-ray diffraction (XRD) and X-ray absorption spectroscopy (XAS) are two main x-ray techniques in synchrotron radiation facilities. In this Note, we present an experimental setup capable of performing simultaneous XRD and XAS measurements by the application of a pixel-array area detector. For XRD, the momentum transfer in specular diffraction was measured by scanning the X-ray energy with fixed incoming and outgoing x-ray angles. By selecting a small fixed region of the detector to collect the XRD signal, the rest of the area was available for collecting the x-ray fluorescence for XAS measurements. The simultaneous measurement of XRD and X-ray absorption near edge structure for Pr0.67Sr0.33MnO3 film was demonstrated as a proof of principle for future time-resolved pump-probe measurements. A static sample makes it easy to maintain an accurate overlap of the X-ray spot and laser pump beam.

MAP Fault Localization Based on Wide Area Synchronous Phasor Measurement Information

NASA Astrophysics Data System (ADS)

Zhang, Yagang; Wang, Zengping

2015-02-01

In the research of complicated electrical engineering, the emergence of phasor measurement units (PMU) is a landmark event. The establishment and application of wide area measurement system (WAMS) in power system has made widespread and profound influence on the safe and stable operation of complicated power system. In this paper, taking full advantage of wide area synchronous phasor measurement information provided by PMUs, we have carried out precise fault localization based on the principles of maximum posteriori probability (MAP). Large numbers of simulation experiments have confirmed that the results of MAP fault localization are accurate and reliable. Even if there are interferences from white Gaussian stochastic noise, the results from MAP classification are also identical to the actual real situation.

Accelerated Simulation of Kinetic Transport Using Variational Principles and Sparsity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Caflisch, Russel

This project is centered on the development and application of techniques of sparsity and compressed sensing for variational principles, PDEs and physics problems, in particular for kinetic transport. This included derivation of sparse modes for elliptic and parabolic problems coming from variational principles. The research results of this project are on methods for sparsity in differential equations and their applications and on application of sparsity ideas to kinetic transport of plasmas.

Simulation debriefing based on principles of transfer of learning: A pilot study.

PubMed

Johnston, Sandra; Coyer, Fiona; Nash, Robyn

2017-09-01

Upon completion of undergraduate nursing courses, new graduates are expected to transition seamlessly into practice. Education providers face challenges in the preparation of undergraduate nurses due to increasing student numbers and decreasing availability of clinical placement sites. High fidelity patient simulation is an integral component of nursing curricula as an adjunct to preparation for clinical placement. Debriefing after simulation is an area where the underlying structure of problems can consciously be explored. When central principles of problems are identified, they can then be used in situations that differ from the simulation experience. Third year undergraduate nursing students participated in a pilot study conducted to test a debriefing intervention where the intervention group (n=7) participated in a simulation, followed by a debriefing based on transfer of learning principles. The control group (n=5) participated in a simulation of the same scenario, followed by a standard debriefing. Students then attended focus group interviews. The results of this pilot test provided preliminary information that the debriefing approach based on transfer of learning principles may be a useful way for student nurses to learn from a simulated experience and consider the application of learning to future clinical encounters. Copyright © 2017 Elsevier Ltd. All rights reserved.

Assessing knowledge and application of emergency risk communication principles among public health workers in China.

PubMed

Cope, James R; Frost, Melinda; Richun, Li; Xie, Ruiqian

2014-06-01

Since 2003, the Chinese National Health and Family Planning Commission (formerly the Ministry of Health) has implemented changes to more effectively communicate risk during public health emergencies. In spite of ongoing improvements, provincial and sub-provincial leaders face barriers, such as established modes of operation, lack of training, shortage of trained risk communicators, and limited understanding and willingness of recipients to mitigate risks. We assessed the current status of and barriers to risk communication knowledge and practice among public health practitioners in China. We designed the survey questionnaire to capture information related to the risk communication core capacities required by international health regulations and common risk communication principles. Our findings showed that risk communication training has successfully developed an awareness of risk communication principles and the ability to implement those principles in practice in China. Future efforts should focus on areas such as a dedicated risk communication workforce, requirements that public health agencies develop a risk communication plan, and additional training for public health practitioners and their partners. It is critical that the infectious diseases prevention and control law be amended to grant provincial and local public health agencies more autonomy to release information.

The concentration principle applied to spaceborne solar arrays. Application to the coorbiting platform mission: Studies synthesis

NASA Astrophysics Data System (ADS)

Laget, R.

1986-01-01

Studies that led to selection of the distributed concentration biplane concept for the solar cell generator to be flown on the coorbiting platform mission, and the major characteristics of such a spaceborne solar array are summarized. It is concluded that there is not a considerable interest in concentration either for array area reduction or cost reduction, although improvements of 15% for both domains are feasible. Only predevelopment activities to verify concentrator performances and system studies to assess respective importance of cost and area saving may increase the level of interest of concentrator solar arrays for this kind of mission.

The Ethics of Information: Absolute Risk Reduction and Patient Understanding of Screening

PubMed Central

Meslin, Eric M.

2008-01-01

Some experts have argued that patients should routinely be told the specific magnitude and absolute probability of potential risks and benefits of screening tests. This position is motivated by the idea that framing risk information in ways that are less precise violates the ethical principle of respect for autonomy and its application in informed consent or shared decision-making. In this Perspective, we consider a number of problems with this view that have not been adequately addressed. The most important challenges stem from the danger that patients will misunderstand the information or have irrational responses to it. Any initiative in this area should take such factors into account and should consider carefully how to apply the ethical principles of respect for autonomy and beneficence. PMID:18421509

State-of-the-art MS technology applications in lung disease.

PubMed

Végvári, Ákos; Döme, Balázs

2011-12-01

Two frontline MS technologies, which have recently gained much attention, are discussed within the scope of this review. Besides a brief summary on the contemporary state of lung cancer and chronic obstructive pulmonary disease, the principles of multiple reaction monitoring and matrix assisted laser desorption ionization (MALDI) MS imaging are presented. A comprehensive overview of quantitative mass spectrometry applications is provided, covering multiple reaction monitoring assay developments for analysis of proteins (biomarkers) and low-molecular-weight compounds (drugs) with a special focus on the disease areas of lung cancer and chronic obstructive pulmonary disease. The MALDI-MS imaging applications are discussed similarly, providing references to studies conducted on lung tissues in order to localize drug compounds and protein biomarkers.

Sensors, Volume 4, Thermal Sensors

NASA Astrophysics Data System (ADS)

Scholz, Jorg; Ricolfi, Teresio

1996-12-01

'Sensors' is the first self-contained series to deal with the whole area of sensors. It describes general aspects, technical and physical fundamentals, construction, function, applications and developments of the various types of sensors. This volume describes the construction and applicational aspects of thermal sensors while presenting a rigorous treatment of the underlying physical principles. It provides a unique overview of the various categories of sensors as well as of specific groups, e.g. temperature sensors (resistance thermometers, thermocouples, and radiation thermometers), noise and acoustic thermometers, heat-flow and mass-flow sensors. Specific facettes of applications are presented by specialists from different fields including process control, automotive technology and cryogenics. This volume is an indispensable reference work and text book for both specialists and newcomers, researchers and developers.

Laser Doppler velocimetry primer

NASA Technical Reports Server (NTRS)

Bachalo, William D.

1985-01-01

Advanced research in experimental fluid dynamics required a familiarity with sophisticated measurement techniques. In some cases, the development and application of new techniques is required for difficult measurements. Optical methods and in particular, the laser Doppler velocimeter (LDV) are now recognized as the most reliable means for performing measurements in complex turbulent flows. And such, the experimental fluid dynamicist should be familiar with the principles of operation of the method and the details associated with its application. Thus, the goals of this primer are to efficiently transmit the basic concepts of the LDV method to potential users and to provide references that describe the specific areas in greater detail.

External trial deep brain stimulation device for the application of desynchronizing stimulation techniques.

PubMed

Hauptmann, C; Roulet, J-C; Niederhauser, J J; Döll, W; Kirlangic, M E; Lysyansky, B; Krachkovskyi, V; Bhatti, M A; Barnikol, U B; Sasse, L; Bührle, C P; Speckmann, E-J; Götz, M; Sturm, V; Freund, H-J; Schnell, U; Tass, P A

2009-12-01

In the past decade deep brain stimulation (DBS)-the application of electrical stimulation to specific target structures via implanted depth electrodes-has become the standard treatment for medically refractory Parkinson's disease and essential tremor. These diseases are characterized by pathological synchronized neuronal activity in particular brain areas. We present an external trial DBS device capable of administering effectively desynchronizing stimulation techniques developed with methods from nonlinear dynamics and statistical physics according to a model-based approach. These techniques exploit either stochastic phase resetting principles or complex delayed-feedback mechanisms. We explain how these methods are implemented into a safe and user-friendly device.

The role of empirical Bayes methodology as a leading principle in modern medical statistics.

PubMed

van Houwelingen, Hans C

2014-11-01

This paper reviews and discusses the role of Empirical Bayes methodology in medical statistics in the last 50 years. It gives some background on the origin of the empirical Bayes approach and its link with the famous Stein estimator. The paper describes the application in four important areas in medical statistics: disease mapping, health care monitoring, meta-analysis, and multiple testing. It ends with a warning that the application of the outcome of an empirical Bayes analysis to the individual "subjects" is a delicate matter that should be handled with prudence and care. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

High frequency ultrasound with color Doppler in dermatology*

PubMed Central

Barcaui, Elisa de Oliveira; Carvalho, Antonio Carlos Pires; Lopes, Flavia Paiva Proença Lobo; Piñeiro-Maceira, Juan; Barcaui, Carlos Baptista

2016-01-01

Ultrasonography is a method of imaging that classically is used in dermatology to study changes in the hypoderma, as nodules and infectious and inflammatory processes. The introduction of high frequency and resolution equipments enabled the observation of superficial structures, allowing differentiation between skin layers and providing details for the analysis of the skin and its appendages. This paper aims to review the basic principles of high frequency ultrasound and its applications in different areas of dermatology. PMID:27438191

Principles for Establishing Ecologically Successful Riparian Corridors

EPA Pesticide Factsheets

Principles for establishing riparian areas. Riparian areas are three‐dimensional ecotones of interaction that include terrestrial and aquatic ecosystems, that extend down into the groundwater, up above the canopy, outward across the floodplain.

A Study of Biblical Sources of Management Principles.

DTIC Science & Technology

1976-07-01

to, currently identified and accepted management principles. The remaining five principles found in the Biblical source have definite United States Air Force application and are offered as proposed principles of management .

Design principles of water sensitive in settlement area on the river banks

NASA Astrophysics Data System (ADS)

Ryanti, E.; Hasriyanti, N.; Utami, W. D.

2018-03-01

This research will formulate the principle of designing settlement area of Kapuas River Pontianak with the approach of water sensitive concept of urban design (WSUD) the densely populated settlement area. By using a case study the approach that is a dense settlement area located on the banks of the river with literature study techniques to formulate the aspects considered and components that are set in the design, descriptive analysis with the rationalistic paradigm for identification characteristics of the settlement in the river banks areas with consideration of WSUD elements and formulate the principles of designing water-sensitive settlement areas. This research is important to do because the problems related to the water management system in the existing riverside settlement in Pontianak has not been maximal to do. So the primary of this research contains several objectives that will be achieved that is identifying the characteristics of riverside settlement area based on consideration of design aspects of the area that are sensitive to water and the principle of designing the area so that the existing problem structure will be formulated in relation to the community’s need for infrastructure in settlement environment and formulate and develop appropriate technology guidelines for integrated water management systems in riverside settlement areas and design techniques for water-sensitive settlements (WSUD).

Evaluation of a peer-reviewed career development and compensation program for physicians at an academic health science center.

PubMed

O'Brodovich, Hugh; Pleinys, Ramune; Laxer, Ronald; Tallett, Susan; Rosenblum, Norman; Sass-Kortsak, Christina

2003-01-01

The Department of Pediatrics at the Hospital for Sick Children, which is funded by an alternative payment plan, has implemented a novel career development and compensation program (CDCP). Job activity profiles were used to more clearly define job expectations, benchmarks guided career development, and peer review was used to assess performance. The objective of this study was to evaluate the departmental pediatricians' satisfaction with the CDCP. Pediatricians, all of whom had undergone CDCP annual reviews, could participate if they had undergone the in-depth triennial CDCP review. Each received a 5-point Likert scale-based questionnaire that asked how well the CDCP had conformed to the principles identified by the department during the development of the CDCP. Anonymous, confidential responses were collated and used to guide focus groups that discussed areas of greatest concern and attempted to identify solutions. Focus groups were led by external facilitators who were experienced in qualitative research. They audiotaped the sessions, transcribed the comments, and analyzed the data with the assistance of a qualitative analysis application. Sixty of the eligible 88 pediatricians participated, and 74% of their responses were that the CDCP had addressed the original principles "somewhat," "to a great extent," or "extremely well." The remainder indicated that some of the principles were either "not addressed" or "only to a small extent" by the CDCP. Results from the 11 focus groups (46 participants) indicated that the CDCP was an improvement over the previous method of career development and determination of the rate of remuneration. Most were also still in agreement with the purpose and design principles. Although they did not want the CDCP to undergo a major redesign, they identified areas that need improvement. Short-, medium-, and long-term action plans to address these areas are under way. Pediatricians at the health science center of the Hospital for Sick Children remain supportive of the CDCP.

Reconceptualization of the Diffusion Process: An Application of Selected Principles from Modern Systems Theory.

ERIC Educational Resources Information Center

Silver, Wayne

A description of the communication behaviors in high innovation societies depends on the application of selected principles from modern systems theory. The first is the principle of equifinality which explains the activities of open systems. If the researcher views society as an open system, he frees himself from the client approach since society…

Modern technologies for retinal scanning and imaging: an introduction for the biomedical engineer

PubMed Central

2014-01-01

This review article is meant to help biomedical engineers and nonphysical scientists better understand the principles of, and the main trends in modern scanning and imaging modalities used in ophthalmology. It is intended to ease the communication between physicists, medical doctors and engineers, and hopefully encourage “classical” biomedical engineers to generate new ideas and to initiate projects in an area which has traditionally been dominated by optical physics. Most of the methods involved are applicable to other areas of biomedical optics and optoelectronics, such as microscopic imaging, spectroscopy, spectral imaging, opto-acoustic tomography, fluorescence imaging etc., all of which are with potential biomedical application. Although all described methods are novel and important, the emphasis of this review has been placed on three technologies introduced in the 1990’s and still undergoing vigorous development: Confocal Scanning Laser Ophthalmoscopy, Optical Coherence Tomography, and polarization-sensitive retinal scanning. PMID:24779618

An optical system adopting liquid crystals with electrical tunability of wavelength and energy density for low level light therapy

NASA Astrophysics Data System (ADS)

Chang, Chia-Ming; Wang, Yu-Jen; Chen, Hung-Shan; Lin, Yi-Hsin; Srivastava, Abhishek K.; Chigrinov, Vladimir G.

2015-09-01

We have developed a bistable negative lens by integrating a polarization switch of ferroelectric liquid crystals (FLCs) with a passively anisotropic focusing element. The proposed lens not only exhibits electrically tunable bistability but also fast response time of sub-milliseconds, which leads to good candidate of optical component in optical system for medical applications. In this paper, we demonstrate an optical system consisting of two FLC phase retarders and one LC lenses that exhibits both of electrically tunable wavelength and size of exposure area. The operating principles and the experimental results are discussed. The tunable spectrum, exposure area size and tunable irradiance are illustrated. Compared to conventional lenses with mechanical movements in the medical light therapy system, our electrically switchable optical system is more practical in the portable applications of light therapy (LLLT).

Optimality and Conductivity for Water Flow: From Landscapes, to Unsaturated Soils, to Plant Leaves

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, H.H.

2012-02-23

Optimality principles have been widely used in many areas. Based on an optimality principle that any flow field will tend toward a minimum in the energy dissipation rate, this work shows that there exists a unified form of conductivity relationship for three different flow systems: landscapes, unsaturated soils and plant leaves. The conductivity, the ratio of water flux to energy gradient, is a power function of water flux although the power value is system dependent. This relationship indicates that to minimize energy dissipation rate for a whole system, water flow has a small resistance (or a large conductivity) at amore » location of large water flux. Empirical evidence supports validity of the relationship for landscape and unsaturated soils (under gravity dominated conditions). Numerical simulation results also show that the relationship can capture the key features of hydraulic structure for a plant leaf, although more studies are needed to further confirm its validity. Especially, it is of interest that according to this relationship, hydraulic conductivity for gravity-dominated unsaturated flow, unlike that defined in the classic theories, depends on not only capillary pressure (or saturation), but also the water flux. Use of the optimality principle allows for determining useful results that are applicable to a broad range of areas involving highly non-linear processes and may not be possible to obtain from classic theories describing water flow processes.« less

An exploration of the biomedical optics course construction of undergraduate biomedical engineering program in medical colleges

NASA Astrophysics Data System (ADS)

Guo, Shijun; Lyu, Jie; Zhang, Peiming

2017-08-01

In this paper, the teaching goals, teaching contents and teaching methods in biomedical optics course construction are discussed. From the dimension of teaching goals, students should master the principle of optical inspection on the human body, diagnosis and treatment of methodology and instruments, through the study of the theory and practice of this course, and can utilize biomedical optics methods to solve practical problems in the clinical medical engineering practice. From the dimension of teaching contents, based on the characteristics of biomedical engineering in medical colleges, the organic integration of engineering aspects, medical optical instruments, and biomedical aspects dispersed in human anatomy, human physiology, clinical medicine fundamental related to the biomedical optics is build. Noninvasive measurement of the human body composition and noninvasive optical imaging of the human body were taken as actual problems in biomedical optics fields. Typical medical applications such as eye optics and laser medicine were also integrated into the theory and practice teaching. From the dimension of teaching methods, referencing to organ-system based medical teaching mode, optical principle and instrument principle were taught by teachers from school of medical instruments, and the histological characteristics and clinical actual need in areas such as digestive diseases and urinary surgery were taught by teachers from school of basic medicine or clinical medicine of medical colleges. Furthermore, clinical application guidance would be provided by physician and surgeons in hospitals.

A nanocompartment system (Synthosome) designed for biotechnological applications.

PubMed

Nallani, Madhavan; Benito, Samantha; Onaca, Ozana; Graff, Alexandra; Lindemann, Marcus; Winterhalter, Mathias; Meier, Wolfgang; Schwaneberg, Ulrich

2006-05-03

A nanocompartment system based on two deletion mutants of the large channel protein FhuA (FhuA Delta1-129; FhuA Delta1-160) and an ABA triblock copolymer (PMOXA-PDMS-PMOXA) has been developed for putative biotechnological applications. FhuA is ideally suited for applications in biotechnology due to its monomeric structure, large pore diameter (39-46 A elliptical cross-section) that ensures rapid compound flux, and solved crystallographic structure. Two areas of application were targeted as proof of principle: (A) selective product recovery in nanocompartments and (B) enzymatic conversion in nanocompartments. Selective recovery of negatively charged compounds has been achieved on the example of sulforhodamine B by using positively charged polylysine molecules as trap inside the nanocompartment. Conversion in nanocompartments has been achieved by 3,3',5,5'-tetramethylbenzidine oxidation employing horseradish peroxidase (HRP).

Risk management in transfusion after the HIV blood contamination crisis in France: the impact of the precautionary principle.

PubMed

Hergon, Eric; Moutel, Grégoire; Duchange, Nathalie; Bellier, Lucile; Rouger, Philippe; Hervé, Christian

2005-10-01

The importance of the precautionary principle in public health was highlighted in France after the HIV contamination of blood products used for transfusion. However, the definition of this principle, its objectives, the way in which it should be applied, and its consequences had not been considered previously. The question as to whether the application of the precautionary principle is appropriate remains unanswered. The aim of this study was to analyze the interpretations of the application of the precautionary principle to determine its consequences in terms of risk management and patient rights. This was accomplished by interviewing persons involved in transfusion medicine. We conducted 33 interviews and describe the issues enunciated for and against the application of the precautionary principle. The precautionary principle concept was confusing to the respondents. A major issue emerging from the interviews was that the precautionary principle was perceived more as a means of protecting the decision maker than as a means of protecting the patient. Taken to its extreme, the use of the precautionary principle could prejudice sound medical decision making. However, it was felt that it also can lead to the introduction of measures that update and gradually reduce risks associated with transfusion.

Functionalised particles using dry powder coating in pharmaceutical drug delivery: promises and challenges.

PubMed

Dahmash, Eman Z; Mohammed, Afzal R

2015-01-01

Production of functionalised particles using dry powder coating is a one-step, environmentally friendly process that paves the way for the development of particles with targeted properties and diverse functionalities. Applying the first principles in physical science for powders, fine guest particles can be homogeneously dispersed over the surface of larger host particles to develop functionalised particles. Multiple functionalities can be modified including: flowability, dispersibility, fluidisation, homogeneity, content uniformity and dissolution profile. The current publication seeks to understand the fundamental underpinning principles and science governing dry coating process, evaluate key technologies developed to produce functionalised particles along with outlining their advantages, limitations and applications and discusses in detail the resultant functionalities and their applications. Dry particle coating is a promising solvent-free manufacturing technology to produce particles with targeted functionalities. Progress within this area requires the development of continuous processing devices that can overcome challenges encountered with current technologies such as heat generation and particle attrition. Growth within this field requires extensive research to further understand the impact of process design and material properties on resultant functionalities.

Applying bioethical principles to human biomonitoring.

PubMed

Harrison, Myron

2008-06-05

Bioethical principles are widely used as a normative framework in areas of human research and medical care. In recent years there has been increasing formalization of their use in public health decisions. The "traditional bioethical principles" are applied in this discussion to the important issue human biomonitoring for environmental exposures. They are: (1) Autonomy--Also known as the "respect for humans" principle, people understand their own best interests; (2) Beneficence--"do good" for people; (3) Nonmaleficence--"do no harm"; (4) Justice--fair distribution of benefits and costs (including risks to health) across stakeholders.Some of the points made are: (1) There is not a single generic bioethical analysis applicable to the use of human biomonitoring data, each specific use requires a separate deliberation; (2) Using unidentified, population-based biomonitoring information for risk assessment or population surveillance raises fewer bioethical concerns than personally identified biomonitoring information such as employed in health screening; (3) Companies should proactively apply normative bioethical principles when considering the disposition of products and by-products in the environment and humans; (4) There is a need for more engagement by scholars on the bioethical issues raised by the use of biomarkers of exposure; (5) Though our scientific knowledge of biology will continue to increase, there will always be a role for methods or frameworks to resolve substantive disagreements in the meaning of this data that are matters of belief rather than knowledge.

Applying bioethical principles to human biomonitoring

PubMed Central

Harrison, Myron

2008-01-01

Bioethical principles are widely used as a normative framework in areas of human research and medical care. In recent years there has been increasing formalization of their use in public health decisions. The "traditional bioethical principles" are applied in this discussion to the important issue human biomonitoring for environmental exposures. They are: (1) Autonomy – Also known as the "respect for humans" principle, people understand their own best interests; (2) Beneficence – "do good" for people; (3) Nonmaleficence – "do no harm"; (4) Justice – fair distribution of benefits and costs (including risks to health) across stakeholders. Some of the points made are: (1) There is not a single generic bioethical analysis applicable to the use of human biomonitoring data, each specific use requires a separate deliberation; (2) Using unidentified, population-based biomonitoring information for risk assessment or population surveillance raises fewer bioethical concerns than personally identified biomonitoring information such as employed in health screening; (3) Companies should proactively apply normative bioethical principles when considering the disposition of products and by-products in the environment and humans; (4) There is a need for more engagement by scholars on the bioethical issues raised by the use of biomarkers of exposure; (5) Though our scientific knowledge of biology will continue to increase, there will always be a role for methods or frameworks to resolve substantive disagreements in the meaning of this data that are matters of belief rather than knowledge. PMID:18541074

A precautionary principle for dual use research in the life sciences.

PubMed

Kuhlau, Frida; Höglund, Anna T; Evers, Kathinka; Eriksson, Stefan

2011-01-01

Most life science research entails dual-use complexity and may be misused for harmful purposes, e.g. biological weapons. The Precautionary Principle applies to special problems characterized by complexity in the relationship between human activities and their consequences. This article examines whether the principle, so far mainly used in environmental and public health issues, is applicable and suitable to the field of dual-use life science research. Four central elements of the principle are examined: threat, uncertainty, prescription and action. Although charges against the principle exist - for example that it stifles scientific development, lacks practical applicability and is poorly defined and vague - the analysis concludes that a Precautionary Principle is applicable to the field. Certain factors such as credibility of the threat, availability of information, clear prescriptive demands on responsibility and directives on how to act, determine the suitability and success of a Precautionary Principle. Moreover, policy-makers and researchers share a responsibility for providing and seeking information about potential sources of harm. A central conclusion is that the principle is meaningful and useful if applied as a context-dependent moral principle and allowed flexibility in its practical use. The principle may then inspire awareness-raising and the establishment of practical routines which appropriately reflect the fact that life science research may be misused for harmful purposes. © 2009 Blackwell Publishing Ltd.

The Application of Gestalt Principles in Classroom Teaching

ERIC Educational Resources Information Center

Phillips, Mark

1976-01-01

Discusses the application of principles and techniques derived from Gestalt therapy to education. Initial investigations of the results of these applications have noted significant benefits to both teachers and students, including personal control, self-knowledge and self-esteem. For journal availability, see SO 504 730. (Author/DB)

Cardiac imaging: does radiation matter?

PubMed Central

Einstein, Andrew J.; Knuuti, Juhani

2012-01-01

The use of ionizing radiation in cardiovascular imaging has generated considerable discussion. Radiation should not be considered in isolation, but rather in the context of a careful examination of the benefits, risks, and costs of cardiovascular imaging. Such consideration requires an understanding of some fundamental aspects of the biology, physics, epidemiology, and terminology germane to radiation, as well as principles of radiological protection. This paper offers a concise, contemporary perspective on these areas by addressing pertinent questions relating to radiation and its application to cardiac imaging. PMID:21828062

[The organization of scientific innovative laboratory complex of modern technologies].

PubMed

Totskaia, E G; Rozhnova, O M; Mamonova, E V

2013-01-01

The article discusses the actual issues of scientific innovative activity during the realization of principles of private-public partnership. The experience of development of model of scientific innovative complex is presented The possibilities to implement research achievements and their application in the area of cell technologies, technologies of regenerative medicine, biochip technologies are demonstrated. The opportunities to provide high level of diagnostic and treatment in practical health care increase of accessibility and quality of medical care and population health promotion are discussed.

Drugs, money and society (Part II).

PubMed

Walley, Tom

2010-09-01

Pharmacoeconomics started as marketing but has developed into a valuable tool in the fuller assessment of drug therapies. Its principles are now widely accepted, and many countries have government-funded agencies with responsibility for its application, most notably the National Institute for Health and Clinical Excellence in England. Many clinical pharmacologists are active in this area, and the discipline itself is part of the clinical pharmacology trainees' curriculum. Further developments will include value-based pricing and its use in cost sharing arrangements between health service and manufacturers.

Balancing access to participation in research and protection from risks: applying the principle of justice.

PubMed

Kiskaddon, Sarah H

2005-04-01

The problem for Institutional Review Boards (IRBs) of balancing access to participation in research with protection of research subjects has always been a difficult one. IRBs, charged with applying the "Common Rule," as well as the Belmont Principles, in their review of clinical research, are given little guidance on approaching this problem. This article argues that the third Belmont Principle, the Justice Principle, may provide a useful framework for considering this balance. The changing research environment is discussed in an historical context, and the Justice Principle is considered both in the context of individual rights, as well as the potential benefit to classes of people. The author further suggests that application of the Justice Principle be driven by findings derived from an analysis of the first 2 principles. This feedback model will enable a more formal application of the Justice Principle and less ambiguous, more transparent, decisions regarding the equitable selection of subjects. The author calls for more systematic attention to the Justice Principle by IRBs, and proposes a model that includes incorporating the deliberation of the other Belmont Principles into the Justice Principle.

10 CFR 603.625 - Cost principles or standards applicable to for-profit participants.

Code of Federal Regulations, 2011 CFR

2011-01-01

... INVESTMENT AGREEMENTS Award Terms Affecting Participants' Financial, Property, and Purchasing Systems Financial Matters § 603.625 Cost principles or standards applicable to for-profit participants. (a) So as...

RF Tomography for Tunnel Detection: Principles and Inversion Schemes

NASA Astrophysics Data System (ADS)

Lo Monte, L.; Erricolo, D.; Inan, U. S.; Wicks, M. C.

2008-12-01

We propose a novel way to detect underground tunnels based on classical seismic tomography, Ground Penetrating Radar (GPR), inverse scattering principles, and the deployment of distributed sensors, which we call "Distributed RF Tomography". Tunnel detection has been a critical problem that cannot be considered fully solved. Presently, tunnel detection is performed by methods that include seismic sensors, electrical impedance, microgravity, boreholes, and GPR. All of these methods have drawbacks that make them not applicable for use in unfriendly environments, such as battlefields. Specifically, they do not cover wide surface areas, they are generally shallow, they are limited to vertical prospecting, and require the user to be in situ, which may jeopardize one's safety. Additional application of the proposed distributed RF tomography include monitoring sensitive areas, (e.g. banks, power plants, military bases, prisons, national borders) and civil applications (e.g. environmental engineering, mine safety, search and rescue, speleology, archaeology and geophysics). The novelty of a Distributed RF tomography system consists of the following. 1) Sensors are scattered randomly above the ground, thus saving time and money compared to the use of boreholes. 2) The use of lower operating frequency (around HF), which allows for deeper penetration. 3) The use of CW diffraction tomography, which increases the resolution to sub-wavelength values, independently from the sensor displacement, and increases the SNR. 4) Use of linear inversion schemes that are suited for tunnel detection. 5) The use of modulation schemes and signal processing algorithms to mitigate interferences and noise. This presentation will cover: 1. Current physical limits of existing techniques for tunnel detection. 2. Concept of Distributed RF Tomography. 3. Inversion theories and strategies a. Proper forward model for voids buried into an homogeneous medium b. Extended matched filtering inversion c. Near field formulation : Dyadic representation d. Fourier approach: principles and techniques aimed at improving the reconstructed image. e. Theoretical Limits f. Super-Resolution : Singular Values Decomposition and MUSIC 4. Propagation Model and theoretical limitations. 5. Transmitting and Receiving design, with signal processing and modulation. 6. Numerical Simulations using FDTD tools.

The Power of “Principles” in a National Pharmaceuticals Strategy

PubMed Central

MacPherson, Catherine S.; Kenny, Nuala P.

2009-01-01

The role of principles in shaping the development of public policy has garnered increasing attention. The authors explore the role of underlying principles in the development of a Canadian National Pharmaceuticals Strategy (NPS), an area in which practical policy development has been disappointing. In analyzing proposed principles for a NPS identified in government documents and by a set of major stakeholder coalitions, they find broad agreement on principles underlying a NPS, particularly regarding equity, accessibility, safety and effectiveness. However, the identification of principles for a NPS has not motivated practical policy progress in this crucial area. Some reasons for this failure are rooted in the current state of ethics and principles in health policy and some in the value-laden, interest-dominated nature of pharmaceutical policy itself. PMID:19377353

System design considerations for a production-grade, ESR-based x-ray lithography beamline

NASA Astrophysics Data System (ADS)

Kovacs, Stephen; Melore, Dan; Cerrina, Franco; Cole, Richard K.

1991-08-01

As electron storage ring (ESR) based x-ray lithography technology moves closer to becoming an industrial reality, more and more attention has been devoted to studying problem areas related to its application in the production environment. A principle component is the x-ray lithography beamline (XLBL) and its associated design requirements. XLBL, an x-ray radiation transport system, is one of the three major subunits in the ESR-based x-ray lithography system (XLS) and has a pivotal role in defining performance characteristics of the entire XLS. Its major functions are to transport the synchrotron orbital radiation (SOR) to the lithography target area with defined efficiency and to modify SOR into the spectral distribution defined by the lithography process window. These functions must be performed reliably in order to satisfy the required high production rate and ensure 0.25 micron resolution lithography conditions. In this paper the authors attempt to answer some specific questions that arise during the formulation of an XLBL system design. Three principle issues that are essential to formulating a design are (1) Radiation transport efficiency, (2) X-ray optical configurations in the beamline, (3) Beamline system configurations. Some practical solutions to thee problem areas are presented, and the effects of these parameters on lithography production rate are examined.

Principles of Pesticide Use, Handling, and Application: Instructional Modules for Vocational Agriculture Education. Student Manual.

ERIC Educational Resources Information Center

Ellis Associates, Inc., College Park, MD.

This training package is designed to present the basic principles of pesticide use, handling, and application. Included in this package is information on federal laws and regulations, personal safety, environmental implications, storage and disposal considerations, proper application procedures, and fundamentals of pest management. Successful…

Principles of Pesticide Use, Handling, and Application: Instructional Modules for Vocational Agriculture Education. Teacher Manual.

ERIC Educational Resources Information Center

Ellis Associates, Inc., College Park, MD.

The training package is designed to present the basic principles of pesticide use, handling, and application. Included in this package is information on Federal laws and regulations, personal safety, environmental implications, storage and disposal considerations, proper application procedures, and fundamentals of pest management. Successful…

Application of Satellite Based Augmentation Systems to Altitude Separation

NASA Astrophysics Data System (ADS)

Magny, Jean Pierre

This paper presents the application of GNSS1, or more precisely of Satellite Based Augmentation Systems (SBAS), to vertical separation for en-route, approach and landing operations. Potential improvements in terms of operational benefit and of safety are described for two main applications. First, vertical separation between en-route aircraft, which requires a system available across wide areas. SBAS (EGNOS, WAAS, and MSAS) are very well suited for this purpose before GNSS2 becomes available. And secondly, vertical separation from the ground during approach and landing, for which preliminary design principles of instrument approach procedures and safety issues are presented. Approach and landing phases are the subject of discussions within ICAO GNSS-P. En-route phases have been listed as GNSS-P future work and by RTCA for development of new equipments.

Assessing climate change-robustness of protected area management plans-The case of Germany.

PubMed

Geyer, Juliane; Kreft, Stefan; Jeltsch, Florian; Ibisch, Pierre L

2017-01-01

Protected areas are arguably the most important instrument of biodiversity conservation. To keep them fit under climate change, their management needs to be adapted to address related direct and indirect changes. In our study we focus on the adaptation of conservation management planning, evaluating management plans of 60 protected areas throughout Germany with regard to their climate change-robustness. First, climate change-robust conservation management was defined using 11 principles and 44 criteria, which followed an approach similar to sustainability standards. We then evaluated the performance of individual management plans concerning the climate change-robustness framework. We found that climate change-robustness of protected areas hardly exceeded 50 percent of the potential performance, with most plans ranking in the lower quarter. Most Natura 2000 protected areas, established under conservation legislation of the European Union, belong to the sites with especially poor performance, with lower values in smaller areas. In general, the individual principles showed very different rates of accordance with our principles, but similarly low intensity. Principles with generally higher performance values included holistic knowledge management, public accountability and acceptance as well as systemic and strategic coherence. Deficiencies were connected to dealing with the future and uncertainty. Lastly, we recommended the presented principles and criteria as essential guideposts that can be used as a checklist for working towards more climate change-robust planning.

Assessing climate change-robustness of protected area management plans—The case of Germany

PubMed Central

Geyer, Juliane; Kreft, Stefan; Jeltsch, Florian; Ibisch, Pierre L.

2017-01-01

Protected areas are arguably the most important instrument of biodiversity conservation. To keep them fit under climate change, their management needs to be adapted to address related direct and indirect changes. In our study we focus on the adaptation of conservation management planning, evaluating management plans of 60 protected areas throughout Germany with regard to their climate change-robustness. First, climate change-robust conservation management was defined using 11 principles and 44 criteria, which followed an approach similar to sustainability standards. We then evaluated the performance of individual management plans concerning the climate change-robustness framework. We found that climate change-robustness of protected areas hardly exceeded 50 percent of the potential performance, with most plans ranking in the lower quarter. Most Natura 2000 protected areas, established under conservation legislation of the European Union, belong to the sites with especially poor performance, with lower values in smaller areas. In general, the individual principles showed very different rates of accordance with our principles, but similarly low intensity. Principles with generally higher performance values included holistic knowledge management, public accountability and acceptance as well as systemic and strategic coherence. Deficiencies were connected to dealing with the future and uncertainty. Lastly, we recommended the presented principles and criteria as essential guideposts that can be used as a checklist for working towards more climate change-robust planning. PMID:28982187

Management of water repellency in Australia, and risks associated with preferential flow, pesticide concentration and leaching

NASA Astrophysics Data System (ADS)

Blackwell, P. S.

2000-05-01

The three most westerly states of southern Australia have the largest area of water repellent soils, which limit agricultural production, of any country in the world. Simplified principles of the problems caused by repellency and the principles of soil management solutions are considered and related to experimental evidence. The phenomena of diverted soil water flow and isolated dry soil can explain most of the problems caused by repellency. Plant adaptation, soil or hydrophobic removal, reduced soil drying, reduced surface tension, water harvesting, avoidance, masking and, perhaps, water movement along dead root systems are the main soil management principles. Dead roots may play a role in zero till cropping systems, allowing more uniform wetting of dry hydrophobic soil at the base of a dead plant and along the dendritic pattern of the dead root system. Application of these management principles, especially water harvesting, avoidance and masking (by the use of deep trenching, furrow sowing methods or claying), have made a considerable improvement to sustainability and productivity of farming systems on the water repellent soils of Australia. Evidence is selected to assess risks of preferential flow, pesticide concentration and leaching for different agricultural soil management methods. All management methods can have some risks, but claying seems to have the least risk and furrowing the highest risk of encouraging preferential flow, pesticide concentration and leaching. It is suggested we have insufficient information and understanding to quantify the risks of groundwater contamination for different environments, farming systems and soil management methods to control repellency. There is an urgent need to develop quantified guidelines to minimise any possible groundwater contamination hazard for the extensive areas using farming systems with furrows and increasing amounts of pesticide and fertiliser.

Underlying Principles of Natural Selection in Network Evolution: Systems Biology Approach

PubMed Central

Chen, Bor-Sen; Wu, Wei-Sheng

2007-01-01

Systems biology is a rapidly expanding field that integrates diverse areas of science such as physics, engineering, computer science, mathematics, and biology toward the goal of elucidating the underlying principles of hierarchical metabolic and regulatory systems in the cell, and ultimately leading to predictive understanding of cellular response to perturbations. Because post-genomics research is taking place throughout the tree of life, comparative approaches offer a way for combining data from many organisms to shed light on the evolution and function of biological networks from the gene to the organismal level. Therefore, systems biology can build on decades of theoretical work in evolutionary biology, and at the same time evolutionary biology can use the systems biology approach to go in new uncharted directions. In this study, we present a review of how the post-genomics era is adopting comparative approaches and dynamic system methods to understand the underlying design principles of network evolution and to shape the nascent field of evolutionary systems biology. Finally, the application of evolutionary systems biology to robust biological network designs is also discussed from the synthetic biology perspective. PMID:19468310

2 CFR Appendix A to Part 220 - Principles for Determining Costs Applicable to Grants, Contracts, and Other Agreements With...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Principles for Determining Costs Applicable to Grants, Contracts, and Other Agreements With Educational Institutions A Appendix A to Part 220 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET CIRCULARS AND GUIDANCE Reserved COST PRINCIPLES FOR EDUCATIONAL INSTITUTIONS (OMB CIRCULAR A-21)...

7 CFR 3430.31 - Guiding principles.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Guiding principles. 3430.31 Section 3430.31 Agriculture Regulations of the Department of Agriculture (Continued) COOPERATIVE STATE RESEARCH, EDUCATION... § 3430.31 Guiding principles. The guiding principle for Federal assistance application review and...

Object-Oriented Programming When Developing Software in Geology and Geophysics

NASA Astrophysics Data System (ADS)

Ahmadulin, R. K.; Bakanovskaya, L. N.

2017-01-01

The paper reviews the role of object-oriented programming when developing software in geology and geophysics. Main stages have been identified at which it is worthwhile to apply principles of object-oriented programming when developing software in geology and geophysics. The research was based on a number of problems solved in Geology and Petroleum Production Institute. Distinctive features of these problems are given and areas of application of the object-oriented approach are identified. Developing applications in the sphere of geology and geophysics has shown that the process of creating such products is simplified due to the use of object-oriented programming, firstly when designing structures for data storage and graphical user interfaces.

Methods for Engineering Sulfate Reducing Bacteria of the Genus Desulfovibrio

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chhabra, Swapnil R; Keller, Kimberly L.; Wall, Judy D.

Sulfate reducing bacteria are physiologically important given their nearly ubiquitous presence and have important applications in the areas of bioremediation and bioenergy. This chapter provides details on the steps used for homologous-recombination mediated chromosomal manipulation of Desulfovibrio vulgaris Hildenborough, a well-studied sulfate reducer. More specifically, we focus on the implementation of a 'parts' based approach for suicide vector assembly, important aspects of anaerobic culturing, choices for antibiotic selection, electroporation-based DNA transformation, as well as tools for screening and verifying genetically modified constructs. These methods, which in principle may be extended to other sulfate-reducing bacteria, are applicable for functional genomics investigations,more » as well as metabolic engineering manipulations.« less

First-principles Electronic Structure Calculations for Scintillation Phosphor Nuclear Detector Materials

NASA Astrophysics Data System (ADS)

Canning, Andrew

2013-03-01

Inorganic scintillation phosphors (scintillators) are extensively employed as radiation detector materials in many fields of applied and fundamental research such as medical imaging, high energy physics, astrophysics, oil exploration and nuclear materials detection for homeland security and other applications. The ideal scintillator for gamma ray detection must have exceptional performance in terms of stopping power, luminosity, proportionality, speed, and cost. Recently, trivalent lanthanide dopants such as Ce and Eu have received greater attention for fast and bright scintillators as the optical 5d to 4f transition is relatively fast. However, crystal growth and production costs remain challenging for these new materials so there is still a need for new higher performing scintillators that meet the needs of the different application areas. First principles calculations can provide a useful insight into the chemical and electronic properties of such materials and hence can aid in the search for better new scintillators. In the past there has been little first-principles work done on scintillator materials in part because it means modeling f electrons in lanthanides as well as complex excited state and scattering processes. In this talk I will give an overview of the scintillation process and show how first-principles calculations can be applied to such systems to gain a better understanding of the physics involved. I will also present work on a high-throughput first principles approach to select new scintillator materials for fabrication as well as present more detailed calculations to study trapping process etc. that can limit their brightness. This work in collaboration with experimental groups has lead to the discovery of some new bright scintillators. Work supported by the U.S. Department of Homeland Security and carried out under U.S. Department of Energy Contract no. DE-AC02-05CH11231 at Lawrence Berkeley National Laboratory.

7 CFR 2.11 - New principles and periodic reviews.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 1 2010-01-01 2010-01-01 false New principles and periodic reviews. 2.11 Section 2.11... Agriculture § 2.11 New principles and periodic reviews. In the exercise of authority delegated by the Secretary, the application of new principles of major importance or a departure from principles established...

[New trends in tonometry].

PubMed

Draeger, J A; Schwenteck, T; Ruokonen, P C

2006-10-01

Though the knowledge about the risk of elevated intraocular pressure for pathogenesis for development and progress of glaucoma is more than 400 years old. It took another 300 years before by means of tonometry this elevation could be quantified. After discussion of the key words it is our aim to demonstrate the latest trends in tonometry, specifically by use of modern electronics for instrument design. Goldmann was the founder of the "applanation tonometry", measuring the corelation of applanated area and applied force. Here, the next step was the development of instruments, measuring independent of position or gravity to allow application also at the lying patient. Electronic area detection was the next step to avoid examinor's error. Also important was the introduction of automatic UV-desinfection to avoid contamination of the other eye or other patients. Other tonometers control the force applied by an inductive method, which also allows application independent of position. Airpuff-tonometry uses completely different measuring principles - the resulting change of corneal curvature indicates the intraocular pressure. The impedance principle is applied even through the closed eye lid. The shock waves resulting shall be measured. Direct application of a surface sensor incorporated into a concave surface contact body shall allow direct measurement of intraocular pressure independent of corneal thickness, curvature, astigmatism. This method has been tried for more than 20 years. Also exposition of the eye to count waves of different frequency was an early attempt. Here also change of reflectivity is used to calculate intraocular pressure. Even after use of modern electronic technology the precision of many of these new devices does not lead to better results. This specifically is shown by modern calibration methods.

77 FR 22797 - Submission of Proposed Information Collection to OMB: Certification of Consistency and Nexus...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-17

... Applicant With Livability Principles Advanced in Preferred Sustainability Status Communities AGENCY: Office... Sustainability Status Community using form HUD-2995 which verifies that the applicant has met the above criteria... Principles as they are being advanced in the Preferred Sustainability Status Communities. If the applicant is...

Synthetic biology: navigating the challenges ahead.

PubMed

Bhutkar, Arjun

2005-01-01

The emerging field of synthetic biology is broadly defined as the area of intersection of biology and engineering that focuses on the modification or creation of novel biological systems that do not have a counterpart in nature. Potential applications of this technology range from creating systems for environmental cleanup tasks, for medical diagnosis and treatment, to economical generation of hydrogen fuel. This technology is in tis nascent state and there are a number of concerns surrounding its potential applications and the nature of research being performed. With the potential to create hitherto unknown "living organisms", it raises a number of challenges along different dimensions. This article reviews the current state of the technology and analyzes synthetic biology using different lenses: patentability, ethics, and regulation. It proposes a classification system for the products of synthetic biology and provides recommendations in each of the above areas (patentability, ethics, and regulation) in the context of this classification system. These recommendations include an improved framework for patentability testing, ethical principles to guide work in this area, a controlled approval process, and reference frameworks for regulation.

Ethical principles in federal regulations: the case of children and research risks.

PubMed

Williams, P C

1996-04-01

Ethical principles play an important part not only in the promulgation of regulations but also in their application, i.e., enforcement and adjudication. while traditional ethical principles--promotion of welfare, freedom, and fairness--play an important role in both elements of regulation, some other kinds of ethical principles are significant as well. Principles governing the structure of decision processes should shape the structure and actions of agencies; principles of wise application should govern the work of those whose responsibility it is to apply regulatory language to particular situations. These points are demonstrated by investigating a case study: federal regulations designed to protect children involved in scientific research applied to a placebo study of the effects of recombinant human growth hormone on children of extremely short stature.

Recent advances in the analysis of behavioural organization and interpretation as indicators of animal welfare

PubMed Central

Asher, Lucy; Collins, Lisa M.; Ortiz-Pelaez, Angel; Drewe, Julian A.; Nicol, Christine J.; Pfeiffer, Dirk U.

2009-01-01

While the incorporation of mathematical and engineering methods has greatly advanced in other areas of the life sciences, they have been under-utilized in the field of animal welfare. Exceptions are beginning to emerge and share a common motivation to quantify ‘hidden’ aspects in the structure of the behaviour of an individual, or group of animals. Such analyses have the potential to quantify behavioural markers of pain and stress and quantify abnormal behaviour objectively. This review seeks to explore the scope of such analytical methods as behavioural indicators of welfare. We outline four classes of analyses that can be used to quantify aspects of behavioural organization. The underlying principles, possible applications and limitations are described for: fractal analysis, temporal methods, social network analysis, and agent-based modelling and simulation. We hope to encourage further application of analyses of behavioural organization by highlighting potential applications in the assessment of animal welfare, and increasing awareness of the scope for the development of new mathematical methods in this area. PMID:19740922

76 FR 38146 - Revision to the Final Principles of Integrated Resource Planning for Use in Resource Acquisition...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-29

... DEPARTMENT OF ENERGY Western Area Power Administration Revision to the Final Principles of... Administration (Western) published proposed Principles for Integrated Resource planning (IRP) for use in its... December 6, 1994. After considering public comments on the proposed principles, Western adopted the Final...

THz Medical Imaging: in vivo Hydration Sensing

PubMed Central

Taylor, Zachary D.; Singh, Rahul S.; Bennett, David B.; Tewari, Priyamvada; Kealey, Colin P.; Bajwa, Neha; Culjat, Martin O.; Stojadinovic, Alexander; Lee, Hua; Hubschman, Jean-Pierre; Brown, Elliott R.; Grundfest, Warren S.

2015-01-01

The application of THz to medical imaging is experiencing a surge in both interest and federal funding. A brief overview of the field is provided along with promising and emerging applications and ongoing research. THz imaging phenomenology is discussed and tradeoffs are identified. A THz medical imaging system, operating at ~525 GHz center frequency with ~125 GHz of response normalized bandwidth is introduced and details regarding principles of operation are provided. Two promising medical applications of THz imaging are presented: skin burns and cornea. For burns, images of second degree, partial thickness burns were obtained in rat models in vivo over an 8 hour period. These images clearly show the formation and progression of edema in and around the burn wound area. For cornea, experimental data measuring the hydration of ex vivo porcine cornea under drying is presented demonstrating utility in ophthalmologic applications. PMID:26085958

Documentation of a spatial data-base management system for monitoring pesticide application in Washington

USGS Publications Warehouse

Schurr, K.M.; Cox, S.E.

1994-01-01

The Pesticide-Application Data-Base Management System was created as a demonstration project and was tested with data submitted to the Washington State Department of Agriculture by pesticide applicators from a small geographic area. These data were entered into the Department's relational data-base system and uploaded into the system's ARC/INFO files. Locations for pesticide applica- tions are assigned within the Public Land Survey System grids, and ARC/INFO programs in the Pesticide-Application Data-Base Management System can subdivide each survey section into sixteen idealized quarter-quarter sections for display map grids. The system provides data retrieval and geographic information system plotting capabilities from a menu of seven basic retrieval options. Additionally, ARC/INFO coverages can be created from the retrieved data when required for particular applications. The Pesticide-Application Data-Base Management System, or the general principles used in the system, could be adapted to other applica- tions or to other states.

12 CFR 621.3 - Application of generally accepted accounting principles.

Code of Federal Regulations, 2010 CFR

2010-01-01

... principles. 621.3 Section 621.3 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM ACCOUNTING... reports to the Farm Credit Administration, in accordance with generally accepted accounting principles... management and the Farm Credit Administration, in accordance with generally accepted accounting principles...

EDITORIAL: Imaging Systems and Techniques Imaging Systems and Techniques

NASA Astrophysics Data System (ADS)

Giakos, George; Yang, Wuqiang; Petrou, M.; Nikita, K. S.; Pastorino, M.; Amanatiadis, A.; Zentai, G.

2011-10-01

This special feature on Imaging Systems and Techniques comprises 27 technical papers, covering essential facets in imaging systems and techniques both in theory and applications, from research groups spanning three different continents. It mainly contains peer-reviewed articles from the IEEE International Conference on Imaging Systems and Techniques (IST 2011), held in Thessaloniki, Greece, as well a number of articles relevant to the scope of this issue. The multifaceted field of imaging requires drastic adaptation to the rapid changes in our society, economy, environment, and the technological revolution; there is an urgent need to address and propose dynamic and innovative solutions to problems that tend to be either complex and static or rapidly evolving with a lot of unknowns. For instance, exploration of the engineering and physical principles of new imaging systems and techniques for medical applications, remote sensing, monitoring of space resources and enhanced awareness, exploration and management of natural resources, and environmental monitoring, are some of the areas that need to be addressed with urgency. Similarly, the development of efficient medical imaging techniques capable of providing physiological information at the molecular level is another important area of research. Advanced metabolic and functional imaging techniques, operating on multiple physical principles, using high resolution and high selectivity nanoimaging techniques, can play an important role in the diagnosis and treatment of cancer, as well as provide efficient drug-delivery imaging solutions for disease treatment with increased sensitivity and specificity. On the other hand, technical advances in the development of efficient digital imaging systems and techniques and tomographic devices operating on electric impedance tomography, computed tomography, single-photon emission and positron emission tomography detection principles are anticipated to have a significant impact on a wide spectrum of technological areas, such as medical imaging, pharmaceutical industry, analytical instrumentation, aerospace, remote sensing, lidars and ladars, surveillance, national defense, corrosion imaging and monitoring, sub-terrestrial and marine imaging. The complexity of the involved imaging scenarios, and demanding design parameters such as speed, signal-to-noise ratio, high specificity, high contrast and spatial resolution, high-scatter rejection, complex background and harsh environment, necessitate the development of a multifunctional, scalable and efficient imaging suite of sensors, solutions driven by innovation, operating on diverse detection and imaging principles. Finally, pattern recognition and image processing algorithms can significantly contribute to enhanced detection and imaging, including object classification, clustering, feature selection, texture analysis, segmentation, image compression and color representation under complex imaging scenarios, with applications in medical imaging, remote sensing, aerospace, radars, defense and homeland security. We feel confident that the exciting new contributions of this special feature on Imaging Systems and Techniques will appeal to the technical community. We would like to thank all authors as well as all anonymous reviewers and the MST Editorial Board, Publisher and staff for their tremendous efforts and invaluable support to enhance the quality of this significant endeavor.

Applications and requirements for MEMS scanner mirrors

NASA Astrophysics Data System (ADS)

Wolter, Alexander; Hsu, Shu-Ting; Schenk, Harald; Lakner, Hubert K.

2005-01-01

Micro scanning mirrors are quite versatile MEMS devices for the deflection of a laser beam or a shaped beam from another light source. The most exciting application is certainly in laser-scanned displays. Laser television, home cinema and data projectors will display the most brilliant colors exceeding even plasma, OLED and CRT. Devices for front and rear projection will have advantages in size, weight and price. These advantages will be even more important in near-eye virtual displays like head-mounted displays or viewfinders in digital cameras and potentially in UMTS handsets. Optical pattern generation by scanning a modulated beam over an area can be used also in a number of other applications: laser printers, direct writing of photo resist for printed circuit boards or laser marking and with higher laser power laser ablation or material processing. Scanning a continuous laser beam over a printed pattern and analyzing the scattered reflection is the principle of barcode reading in 1D and 2D. This principle works also for identification of signatures, coins, bank notes, vehicles and other objects. With a focused white-light or RGB beam even full color imaging with high resolution is possible from an amazingly small device. The form factor is also very interesting for the application in endoscopes. Further applications are light curtains for intrusion control and the generation of arbitrary line patterns for triangulation. Scanning a measurement beam extends point measurements to 1D or 2D scans. Automotive LIDAR (laser RADAR) or scanning confocal microscopy are just two examples. Last but not least there is the field of beam steering. E.g. for all-optical fiber switches or positioning of read-/write heads in optical storage devices. The variety of possible applications also brings a variety of specifications. This publication discusses various applications and their requirements.

Management under uncertainty: guide-lines for incorporating connectivity into the protection of coral reefs

NASA Astrophysics Data System (ADS)

McCook, L. J.; Almany, G. R.; Berumen, M. L.; Day, J. C.; Green, A. L.; Jones, G. P.; Leis, J. M.; Planes, S.; Russ, G. R.; Sale, P. F.; Thorrold, S. R.

2009-06-01

The global decline in coral reefs demands urgent management strategies to protect resilience. Protecting ecological connectivity, within and among reefs, and between reefs and other ecosystems is critical to resilience. However, connectivity science is not yet able to clearly identify the specific measures for effective protection of connectivity. This article aims to provide a set of principles or practical guidelines that can be applied currently to protect connectivity. These ‘rules of thumb’ are based on current knowledge and expert opinion, and on the philosophy that, given the urgency, it is better to act with incomplete knowledge than to wait for detailed understanding that may come too late. The principles, many of which are not unique to connectivity, include: (1) allow margins of error in extent and nature of protection, as insurance against unforeseen or incompletely understood threats or critical processes; (2) spread risks among areas; (3) aim for networks of protected areas which are: (a) comprehensive and spread—protect all biotypes, habitats and processes, etc., to capture as many possible connections, known and unknown; (b) adequate—maximise extent of protection for each habitat type, and for the entire region; (c) representative—maximise likelihood of protecting the full range of processes and spatial requirements; (d) replicated—multiple examples of biotypes or processes enhances risk spreading; (4) protect entire biological units where possible (e.g. whole reefs), including buffers around core areas. Otherwise, choose bigger rather than smaller areas; (5) provide for connectivity at a wide range of dispersal distances (within and between patches), emphasising distances <20-30 km; and (6) use a portfolio of approaches, including but not limited to MPAs. Three case studies illustrating the application of these principles to coral reef management in the Bohol Sea (Philippines), the Great Barrier Reef (Australia) and Kimbe Bay (Papua New Guinea) are described.

Teaching General Principles and Applications of Dendrogeomorphology.

ERIC Educational Resources Information Center

Butler, David R.

1987-01-01

Tree-ring analysis in geomorphology can be incorporated into a number of undergraduate methods in order to reconstruct the history of a variety of geomorphic processes. Discusses dendrochronology, general principles of dendrogeomorphology, field sampling methods, laboratory techniques, and examples of applications. (TW)

Software for Fermat's Principle and Lenses

ERIC Educational Resources Information Center

Mihas, Pavlos

2012-01-01

Fermat's principle is considered as a unifying concept. It is usually presented erroneously as a "least time principle". In this paper we present some software that shows cases of maxima and minima and the application of Fermat's principle to the problem of focusing in lenses. (Contains 12 figures.)

The 5C Concept and 5S Principles in Inflammatory Bowel Disease Management

PubMed Central

Hibi, Toshifumi; Panaccione, Remo; Katafuchi, Miiko; Yokoyama, Kaoru; Watanabe, Kenji; Matsui, Toshiyuki; Matsumoto, Takayuki; Travis, Simon; Suzuki, Yasuo

2017-01-01

Abstract Background and Aims The international Inflammatory Bowel Disease [IBD] Expert Alliance initiative [2012–2015] served as a platform to define and support areas of best practice in IBD management to help improve outcomes for all patients with IBD. Methods During the programme, IBD specialists from around the world established by consensus two best practice charters: the 5S Principles and the 5C Concept. Results The 5S Principles were conceived to provide health care providers with key guidance for improving clinical practice based on best management approaches. They comprise the following categories: Stage the disease; Stratify patients; Set treatment goals; Select appropriate treatment; and Supervise therapy. Optimised management of patients with IBD based on the 5S Principles can be achieved most effectively within an optimised clinical care environment. Guidance on optimising the clinical care setting in IBD management is provided through the 5C Concept, which encompasses: Comprehensive IBD care; Collaboration; Communication; Clinical nurse specialists; and Care pathways. Together, the 5C Concept and 5S Principles provide structured recommendations on organising the clinical care setting and developing best-practice approaches in IBD management. Conclusions Consideration and application of these two dimensions could help health care providers optimise their IBD centres and collaborate more effectively with their multidisciplinary team colleagues and patients, to provide improved IBD care in daily clinical practice. Ultimately, this could lead to improved outcomes for patients with IBD. PMID:28981622

Adopting an ecological view of metropolitan landscape: the case of "three circles" system for ecological construction and restoration in Beijing area.

PubMed

Zhang, Feng; Zhang, Xin-shi

2004-01-01

Ecological construction and restoration for sustainable development are now a driving paradigm. It is increasingly recognized that ecological principles, especially landscape ecology theory, are not only necessary but also essential to maintain the long-term sustainability worldwide. Key landscape ecology principles-element, structure and process, dynamics, heterogeneity, hierarchies, connectivity, place and time were reviewed, and use Beijing area as a case study to illustrate how these principles might be applied to ecological construction and restoration, to eventually achieve sustainability. An example to more effectively incorporate the ecological principles in sustainable planning in China was presented.

Basal area increment and growth efficiency as functions of canopy dynamics and stem mechanics

Treesearch

Thomas J. Dean

2004-01-01

Crown and canopy structurecorrelate with growth efficiency and also determine stem size and taper as described by the uniform stress principle of stem formation. A regression model was derived from this principle that expresses basal area increment in terms of the amount and vertical distribution of leaf area and change in these variables during a growth period. This...

19 CFR 10.824 - Verification and justification of claim for preferential treatment.

Code of Federal Regulations, 2010 CFR

2010-04-01

... accounting principles. When conducting a verification of origin to which Generally Accepted Accounting Principles may be relevant, CBP will apply and accept the Generally Accepted Accounting Principles applicable...

19 CFR 10.784 - Verification and justification of claim for preferential treatment.

Code of Federal Regulations, 2010 CFR

2010-04-01

... accounting principles. When conducting a verification of origin to which Generally Accepted Accounting Principles may be relevant, CBP will apply and accept the Generally Accepted Accounting Principles applicable...

Basic design principles of colorimetric vision systems

NASA Astrophysics Data System (ADS)

Mumzhiu, Alex M.

1998-10-01

Color measurement is an important part of overall production quality control in textile, coating, plastics, food, paper and other industries. The color measurement instruments such as colorimeters and spectrophotometers, used for production quality control have many limitations. In many applications they cannot be used for a variety of reasons and have to be replaced with human operators. Machine vision has great potential for color measurement. The components for color machine vision systems, such as broadcast quality 3-CCD cameras, fast and inexpensive PCI frame grabbers, and sophisticated image processing software packages are available. However the machine vision industry has only started to approach the color domain. The few color machine vision systems on the market, produced by the largest machine vision manufacturers have very limited capabilities. A lack of understanding that a vision based color measurement system could fail if it ignores the basic principles of colorimetry is the main reason for the slow progress of color vision systems. the purpose of this paper is to clarify how color measurement principles have to be applied to vision systems and how the electro-optical design features of colorimeters have to be modified in order to implement them for vision systems. The subject of this presentation far exceeds the limitations of a journal paper so only the most important aspects will be discussed. An overview of the major areas of applications for colorimetric vision system will be discussed. Finally, the reasons why some customers are happy with their vision systems and some are not will be analyzed.

Concept of dynamic memory in economics

NASA Astrophysics Data System (ADS)

Tarasova, Valentina V.; Tarasov, Vasily E.

2018-02-01

In this paper we discuss a concept of dynamic memory and an application of fractional calculus to describe the dynamic memory. The concept of memory is considered from the standpoint of economic models in the framework of continuous time approach based on fractional calculus. We also describe some general restrictions that can be imposed on the structure and properties of dynamic memory. These restrictions include the following three principles: (a) the principle of fading memory; (b) the principle of memory homogeneity on time (the principle of non-aging memory); (c) the principle of memory reversibility (the principle of memory recovery). Examples of different memory functions are suggested by using the fractional calculus. To illustrate an application of the concept of dynamic memory in economics we consider a generalization of the Harrod-Domar model, where the power-law memory is taken into account.

Limits to magnetic resonance microscopy

NASA Astrophysics Data System (ADS)

Glover, Paul; Mansfield, Peter, Sir

2002-10-01

The last quarter of the twentieth century saw the development of magnetic resonance imaging (MRI) grow from a laboratory demonstration to a multi-billion dollar worldwide industry. There is a clinical body scanner in almost every hospital of the developed nations. The field of magnetic resonance microscopy (MRM), after mostly being abandoned by researchers in the first decade of MRI, has become an established branch of the science. This paper reviews the development of MRM over the last decade with an emphasis on the current state of the art. The fundamental principles of imaging and signal detection are examined to determine the physical principles which limit the available resolution. The limits are discussed with reference to liquid, solid and gas phase microscopy. In each area, the novel approaches employed by researchers to push back the limits of resolution are discussed. Although the limits to resolution are well known, the developments and applications of MRM have not reached their limit.

Hydrocarbon-Stapled Peptides: Principles, Practice, and Progress

PubMed Central

2015-01-01

Protein structure underlies essential biological processes and provides a blueprint for molecular mimicry that drives drug discovery. Although small molecules represent the lion’s share of agents that target proteins for therapeutic benefit, there remains no substitute for the natural properties of proteins and their peptide subunits in the majority of biological contexts. The peptide α-helix represents a common structural motif that mediates communication between signaling proteins. Because peptides can lose their shape when taken out of context, developing chemical interventions to stabilize their bioactive structure remains an active area of research. The all-hydrocarbon staple has emerged as one such solution, conferring α-helical structure, protease resistance, cellular penetrance, and biological activity upon successful incorporation of a series of design and application principles. Here, we describe our more than decade-long experience in developing stapled peptides as biomedical research tools and prototype therapeutics, highlighting lessons learned, pitfalls to avoid, and keys to success. PMID:24601557

Reflector automatic acquisition and pointing based on auto-collimation theodolite.

PubMed

Luo, Jun; Wang, Zhiqian; Wen, Zhuoman; Li, Mingzhu; Liu, Shaojin; Shen, Chengwu

2018-01-01

An auto-collimation theodolite (ACT) for reflector automatic acquisition and pointing is designed based on the principle of autocollimators and theodolites. First, the principle of auto-collimation and theodolites is reviewed, and then the coaxial ACT structure is developed. Subsequently, the acquisition and pointing strategies for reflector measurements are presented, which first quickly acquires the target over a wide range and then points the laser spot to the charge coupled device zero position. Finally, experiments are conducted to verify the acquisition and pointing performance, including the calibration of the ACT, the comparison of the acquisition mode and pointing mode, and the accuracy measurement in horizontal and vertical directions. In both directions, a measurement accuracy of ±3″ is achieved. The presented ACT is suitable for automatic pointing and monitoring the reflector over a small scanning area and can be used in a wide range of applications such as bridge structure monitoring and cooperative target aiming.

Ethics in Evaluating a Sociotechnical Intervention With Socially Isolated Older Adults.

PubMed

Waycott, Jenny; Morgans, Amee; Pedell, Sonja; Ozanne, Elizabeth; Vetere, Frank; Kulik, Lars; Davis, Hilary

2015-11-01

The purpose of this article is to consider how ethical principles can inform the effective design and implementation of technology-based interventions that aim to promote the well-being of socially isolated older adults. We evaluated a new iPad application with small groups of older adults. In this article, we reflect on the ethical issues encountered at each stage of the research process. Drawing on the ethical principles of beneficence, research merit and integrity, justice, and respect, we identify key issues to consider in the future design and implementation of social isolation interventions that use new technologies. Key issues include (a) providing sufficient support to facilitate ongoing social interactions, (b) managing older adults' expectations, (c) providing encouragement without coercion, and (d) responding to individual needs. We conclude that it is important to report on ethical challenges incurred when evaluating social isolation interventions to inform future research in this important area. © The Author(s) 2015.

Optimizing technology development and adoption in medical imaging using the principles of innovation diffusion, part II: practical applications.

PubMed

Reiner, Bruce I

2012-02-01

Successful adoption of new technology development can be accentuated by learning and applying the scientific principles of innovation diffusion. This is of particular importance to areas within the medical imaging practice which have lagged in innovation; perhaps, the most notable of which is reporting which has remained relatively stagnant for over a century. While the theoretical advantages of structured reporting have been well documented throughout the medical imaging community, adoption to date has been tepid and largely relegated to the academic and breast imaging communities. Widespread adoption will likely require an alternative approach to innovation, which addresses the heterogeneity and diversity of the practicing radiologist community along with the ever-changing expectations in service delivery. The challenges and strategies for reporting innovation and adoption are discussed, with the goal of adapting and customizing new technology to the preferences and needs of individual end-users.

First-Principles Prediction of Liquid/Liquid Interfacial Tension.

PubMed

Andersson, M P; Bennetzen, M V; Klamt, A; Stipp, S L S

2014-08-12

The interfacial tension between two liquids is the free energy per unit surface area required to create that interface. Interfacial tension is a determining factor for two-phase liquid behavior in a wide variety of systems ranging from water flooding in oil recovery processes and remediation of groundwater aquifers contaminated by chlorinated solvents to drug delivery and a host of industrial processes. Here, we present a model for predicting interfacial tension from first principles using density functional theory calculations. Our model requires no experimental input and is applicable to liquid/liquid systems of arbitrary compositions. The consistency of the predictions with experimental data is significant for binary, ternary, and multicomponent water/organic compound systems, which offers confidence in using the model to predict behavior where no data exists. The method is fast and can be used as a screening technique as well as to extend experimental data into conditions where measurements are technically too difficult, time consuming, or impossible.

Reflector automatic acquisition and pointing based on auto-collimation theodolite

NASA Astrophysics Data System (ADS)

Luo, Jun; Wang, Zhiqian; Wen, Zhuoman; Li, Mingzhu; Liu, Shaojin; Shen, Chengwu

2018-01-01

An auto-collimation theodolite (ACT) for reflector automatic acquisition and pointing is designed based on the principle of autocollimators and theodolites. First, the principle of auto-collimation and theodolites is reviewed, and then the coaxial ACT structure is developed. Subsequently, the acquisition and pointing strategies for reflector measurements are presented, which first quickly acquires the target over a wide range and then points the laser spot to the charge coupled device zero position. Finally, experiments are conducted to verify the acquisition and pointing performance, including the calibration of the ACT, the comparison of the acquisition mode and pointing mode, and the accuracy measurement in horizontal and vertical directions. In both directions, a measurement accuracy of ±3″ is achieved. The presented ACT is suitable for automatic pointing and monitoring the reflector over a small scanning area and can be used in a wide range of applications such as bridge structure monitoring and cooperative target aiming.

Atomic structure and electronic properties of MgO grain boundaries in tunnelling magnetoresistive devices

PubMed Central

Bean, Jonathan J.; Saito, Mitsuhiro; Fukami, Shunsuke; Sato, Hideo; Ikeda, Shoji; Ohno, Hideo; Ikuhara, Yuichi; McKenna, Keith P.

2017-01-01

Polycrystalline metal oxides find diverse applications in areas such as nanoelectronics, photovoltaics and catalysis. Although grain boundary defects are ubiquitous their structure and electronic properties are very poorly understood since it is extremely challenging to probe the structure of buried interfaces directly. In this paper we combine novel plan-view high-resolution transmission electron microscopy and first principles calculations to provide atomic level understanding of the structure and properties of grain boundaries in the barrier layer of a magnetic tunnel junction. We show that the highly [001] textured MgO films contain numerous tilt grain boundaries. First principles calculations reveal how these grain boundaries are associated with locally reduced band gaps (by up to 3 eV). Using a simple model we show how shunting a proportion of the tunnelling current through grain boundaries imposes limits on the maximum magnetoresistance that can be achieved in devices. PMID:28374755

Ethical principles in health research and review process.

PubMed

Tangwa, Godfrey B

2009-11-01

In this paper I want to reflect on the fundamental ethical principles and their application in different particular contexts, especially in health research and the ethics review process. Four fundamental ethical principles have been identified and widely discussed in bioethical literature. These principles namely are: autonomy or respect for others, beneficence, non-maleficence and justice. These principles have cross-cultural validity, relevance and applicability. Every real-life situation and every concrete particular case in which ethical decision-making is called-for is unique and different from all others; but the same fundamental ethical principles are relevant and used in addressing all such cases and situations. Very often ethical problems will present themselves in the form of dilemmas and it is then necessary to use the same fundamental principles to analyze the situations, to argue persuasively and cogently with competence for the best options or choices in such situations. The issues I will be dealing with in this paper are necessarily more abstract and theoretical, but we will be discussing them from a very practical viewpoint and impulse, with a view to application in concrete real-life situations. The paper ends with some sample practical examples of cases that the reader can use to test his/her grasp of the principles, how to apply them, how to balance them in differing situations and contexts and how to adjudicate between them when they seem to be in conflict.

The Effect of Principle-Procedure and Procedure-Principle Sequencing on Learning Outcomes. IDD&E Working Paper No. 19.

ERIC Educational Resources Information Center

Lim-Quek, Muriel; And Others

This study tested the effects of two instructional sequences--principle-procedure and procedure-principle--on the application and transfer of learning. It was hypothesized that a principle-procedure sequence would result in better near-transfer and far-transfer and that students would prefer this sequence. The 38 freshmen enrolled in a business…

Concept-Development of a Structure Supported Membrane for Deployable Space Applications - From Nature to Manufacture and Testing

NASA Technical Reports Server (NTRS)

Zander, Martin; Belvin, W. K.

2012-01-01

Current space applications of membrane structures include large area solar power arrays, solar sails, antennas, and numerous other large aperture devices like the solar shades of the new James Webb Space Telescope. These expandable structural systems, deployed in-orbit to achieve the desired geometry, are used to collect, reflect and/or transmit electromagnetic radiation. This work, a feasibility study supporting a diploma thesis, describes the systematic process for developing a biologically inspired concept for a structure supported (integrated) membrane, that features a rip stop principle, makes self-deployment possible and is part of an ultra-light weight space application. Novel manufacturing of membrane prototypes and test results are presented for the rip-stop concepts. Test data showed that the new membrane concept has a higher tear resistance than neat film of equivalent mass.

ALARA implementation throughout project life cycle

DOE Office of Scientific and Technical Information (OSTI.GOV)

Haynes, M.J.

1995-03-01

A strength of radiation protection programs generally has been endorsement and application of the ALARA principle. In Ontario Hydro, which currently operates 20 commercial size nuclear units, great strides have been made in the last three decades in reducing occupational radiation exposure per unit of electricity generated. This paper will discuss specific applications of elements of the overall ALARA program which have most contributed to dose reduction as the nuclear program has expanded. This includes such things as management commitment, ALARA application in the design phase and major rehabilitation work, the benefits of the self protection concept, a specific examplemore » of elimination (or reduction) of the source term and the importance of dose targets. Finally, it is concluded that the major opportunities for further improvements may lie in the area of information management.« less

Dielectrophoresis for Biomedical Sciences Applications: A Review

PubMed Central

Abd Rahman, Nurhaslina; Ibrahim, Fatimah; Yafouz, Bashar

2017-01-01

Dielectrophoresis (DEP) is a label-free, accurate, fast, low-cost diagnostic technique that uses the principles of polarization and the motion of bioparticles in applied electric fields. This technique has been proven to be beneficial in various fields, including environmental research, polymer research, biosensors, microfluidics, medicine and diagnostics. Biomedical science research is one of the major research areas that could potentially benefit from DEP technology for diverse applications. Nevertheless, many medical science research investigations have yet to benefit from the possibilities offered by DEP. This paper critically reviews the fundamentals, recent progress, current challenges, future directions and potential applications of research investigations in the medical sciences utilizing DEP technique. This review will also act as a guide and reference for medical researchers and scientists to explore and utilize the DEP technique in their research fields. PMID:28245552

42 CFR 417.536 - Cost payment principles.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 3 2010-10-01 2010-10-01 false Cost payment principles. 417.536 Section 417.536... PREPAYMENT PLANS Medicare Payment: Cost Basis § 417.536 Cost payment principles. (a) Applicability. Unless otherwise specified in this subpart, the principles set forth in parts 412 and 413 of this chapter are...

Implementing healthcare information security: standards can help.

PubMed

Orel, Andrej; Bernik, Igor

2013-01-01

Using widely spread common approaches to systems security in health dedicated controlled environments, a level of awareness, confidence and acceptance of relevant standardisation is evaluated. Patients' information is sensitive, so putting appropriate organisational techniques as well as modern technology in place to secure health information is of paramount importance. Mobile devices are becoming the top priorities in advanced information security planning with healthcare environments being no exception. There are less and less application areas in healthcare without having a need for a mobile functionality which represents an even greater information security challenge. This is also true in emergency treatments, rehabilitation and homecare just to mention a few areas outside hospital controlled environments. Unfortunately quite often traditional unsecured communications principles are still in routine use for communicating sensitive health related information. The security awareness level with users, patients and care professionals is not high enough so potential threats and risks may not be addressed and the respective information security management is therefore weak. Standards like ISO/IEC 27000 ISMS family, the ISO/IEC 27799 information security guidelines in health are often not well known, but together with legislation principles such as HIPAA, they can help.

Urban Principle of Water Sensitive Design in Kampung Kamboja at Pontianak City

NASA Astrophysics Data System (ADS)

Hasriyanti, N.; Ryanti, E.

2017-07-01

This study will define the design principles of settlement area banks of the Kapuas Pontianak to approach the concept of water sensitive urban design (WSUD) in densely populated residential areas. Using a case study of a region densely located on the banks of the river with engineering literature to formulate the aspects taken into consideration and the components are arranged in the design, analysis descriptive paradigm rationalistic to identify the characteristics of residential areas riverbank with consideration of elements WSUD and formulate design principles residential area that is sensitive to water. This research is important to do because of problems related to the water management system in the settlement bank of the river in the city of Pontianak do not maximize. So that the primacy of this study contains several objectives to be achieved is to identify the characteristics of the settlement area riverbanks under consideration aspects areas design that is sensitive to water and principle areas design that will formulate the structure of the existing problems related to the needs of the community infrastructure facilities infrastructure neighborhoods and formulate and create guidelines for appropriate technology for integrated water management systems in the residential area of the riverbank and engineering design for the settlements are sensitive to water (WSUD). The final aim of the study is expected to achieve water management systems in residential areas by utilizing the abundant rainwater availability by using LID (Low Impact Development) through the concept of urban design that sensitive water

Some considerations on the definition of risk based on concepts of systems theory and probability.

PubMed

Andretta, Massimo

2014-07-01

The concept of risk has been applied in many modern science and technology fields. Despite its successes in many applicative fields, there is still not a well-established vision and universally accepted definition of the principles and fundamental concepts of the risk assessment discipline. As emphasized recently, the risk fields suffer from a lack of clarity on their scientific bases that can define, in a unique theoretical framework, the general concepts in the different areas of application. The aim of this article is to make suggestions for another perspective of risk definition that could be applied and, in a certain sense, generalize some of the previously known definitions (at least in the fields of technical and scientific applications). By drawing on my experience of risk assessment in different applicative situations (particularly in the risk estimation for major industrial accidents, and in the health and ecological risk assessment for contaminated sites), I would like to revise some general and foundational concepts of risk analysis in as consistent a manner as possible from the axiomatic/deductive point of view. My proposal is based on the fundamental concepts of the systems theory and of the probability. In this way, I try to frame, in a single, broad, and general theoretical context some fundamental concepts and principles applicable in many different fields of risk assessment. I hope that this article will contribute to the revitalization and stimulation of useful discussions and new insights into the key issues and theoretical foundations of risk assessment disciplines. © 2013 Society for Risk Analysis.

Branching angles of pyramidal cell dendrites follow common geometrical design principles in different cortical areas.

PubMed

Bielza, Concha; Benavides-Piccione, Ruth; López-Cruz, Pedro; Larrañaga, Pedro; DeFelipe, Javier

2014-08-01

Unraveling pyramidal cell structure is crucial to understanding cortical circuit computations. Although it is well known that pyramidal cell branching structure differs in the various cortical areas, the principles that determine the geometric shapes of these cells are not fully understood. Here we analyzed and modeled with a von Mises distribution the branching angles in 3D reconstructed basal dendritic arbors of hundreds of intracellularly injected cortical pyramidal cells in seven different cortical regions of the frontal, parietal, and occipital cortex of the mouse. We found that, despite the differences in the structure of the pyramidal cells in these distinct functional and cytoarchitectonic cortical areas, there are common design principles that govern the geometry of dendritic branching angles of pyramidal cells in all cortical areas.

Branching angles of pyramidal cell dendrites follow common geometrical design principles in different cortical areas

PubMed Central

Bielza, Concha; Benavides-Piccione, Ruth; López-Cruz, Pedro; Larrañaga, Pedro; DeFelipe, Javier

2014-01-01

Unraveling pyramidal cell structure is crucial to understanding cortical circuit computations. Although it is well known that pyramidal cell branching structure differs in the various cortical areas, the principles that determine the geometric shapes of these cells are not fully understood. Here we analyzed and modeled with a von Mises distribution the branching angles in 3D reconstructed basal dendritic arbors of hundreds of intracellularly injected cortical pyramidal cells in seven different cortical regions of the frontal, parietal, and occipital cortex of the mouse. We found that, despite the differences in the structure of the pyramidal cells in these distinct functional and cytoarchitectonic cortical areas, there are common design principles that govern the geometry of dendritic branching angles of pyramidal cells in all cortical areas. PMID:25081193

[Analysis of projects funded by NSFC in field of processing Chinese materia medica in recent five years].

PubMed

Chen, Lei; Xia, Xing; He, Bo-sai; Hah, Li-wei

2015-05-01

The general situation of the approved and concluded projects of National Natural Science Foundation of China in the field of processing Chinese Materia Medica in recent five years has been reviewed. The progresses and achievements of some projects have been summarized in accordance with research area such as the processing principle, the processing technology, quality evaluation, toxicity and safety evaluation, etc. The researchers and project support units of the funded projects have been analyzed, and the problems of the applications have been also summarized.

Robotics and automation in Mars exploration

NASA Technical Reports Server (NTRS)

Bourke, Roger D.; Sturms, Francis M., Jr.; Golombek, Matthew P.; Gamber, R. T.

1992-01-01

A new approach to the exploration of Mars is examined which relies on the use of smaller and simpler vehicles. The new strategy involves the following principles: limiting science objectives to retrieval of rock samples from several different but geologically homogeneous areas; making use of emerging microspacecraft technologies to significantly reduce the mass of hardware elements; simplifying missions to the absolutely essential elements; and managing risk through the employment of many identical independent pieces some of which may fail. The emerging technologies and their applications to robotic Mars missions are discussed.

The design method and research status of vehicle detection system based on geomagnetic detection principle

NASA Astrophysics Data System (ADS)

Lin, Y. H.; Bai, R.; Qian, Z. H.

2018-03-01

Vehicle detection systems are applied to obtain real-time information of vehicles, realize traffic control and reduce traffic pressure. This paper reviews geomagnetic sensors as well as the research status of the vehicle detection system. Presented in the paper are also our work on the vehicle detection system, including detection algorithms and experimental results. It is found that the GMR based vehicle detection system has a detection accuracy up to 98% with a high potential for application in the road traffic control area.

Development of a filter regeneration system for advanced spacecraft fluid systems

NASA Technical Reports Server (NTRS)

Behrend, A. F., Jr.; Descamp, V. A.

1974-01-01

The development of a filter regeneration system for efficiently cleaning fluid particulate filters is presented. Based on a backflush/jet impingement technique, the regeneration system demonstrated a cleaning efficiency of 98.7 to 100%. The operating principles and design features are discussed with emphasis on the primary system components that include a regenerable filter, vortex particle separator, and zero-g particle trap. Techniques and equipment used for ground and zero-g performance tests are described. Test results and conclusions, as well as possible areas for commercial application, are included.

Study on Standard Fatigue Vehicle Load Model

NASA Astrophysics Data System (ADS)

Huang, H. Y.; Zhang, J. P.; Li, Y. H.

2018-02-01

Based on the measured data of truck from three artery expressways in Guangdong Province, the statistical analysis of truck weight was conducted according to axle number. The standard fatigue vehicle model applied to industrial areas in the middle and late was obtained, which adopted equivalence damage principle, Miner linear accumulation law, water discharge method and damage ratio theory. Compared with the fatigue vehicle model Specified by the current bridge design code, the proposed model has better applicability. It is of certain reference value for the fatigue design of bridge in China.

A unified approach to computational drug discovery.

PubMed

Tseng, Chih-Yuan; Tuszynski, Jack

2015-11-01

It has been reported that a slowdown in the development of new medical therapies is affecting clinical outcomes. The FDA has thus initiated the Critical Path Initiative project investigating better approaches. We review the current strategies in drug discovery and focus on the advantages of the maximum entropy method being introduced in this area. The maximum entropy principle is derived from statistical thermodynamics and has been demonstrated to be an inductive inference tool. We propose a unified method to drug discovery that hinges on robust information processing using entropic inductive inference. Increasingly, applications of maximum entropy in drug discovery employ this unified approach and demonstrate the usefulness of the concept in the area of pharmaceutical sciences. Copyright © 2015. Published by Elsevier Ltd.

Characterization of the radiation environment for a large-area interim spent-nuclear-fuel storage facility

NASA Astrophysics Data System (ADS)

Fortkamp, Jonathan C.

Current needs in the nuclear industry and movements in the political arena indicate that authorization may soon be given for development of a federal interim storage facility for spent nuclear fuel. The initial stages of the design work have already begun within the Department of Energy and are being reviewed by the Nuclear Regulatory Commission. This dissertation addresses the radiation environment around an interim spent nuclear fuel storage facility. Specifically the dissertation characterizes the radiation dose rates around the facility based on a design basis source term, evaluates the changes in dose due to varying cask spacing configurations, and uses these results to define some applicable health physics principles for the storage facility. Results indicate that dose rates from the facility are due primarily from photons from the spent fuel and Co-60 activation in the fuel assemblies. In the modeled cask system, skyshine was a significant contribution to dose rates at distances from the cask array, but this contribution can be reduced with an alternate cask venting system. With the application of appropriate health physics principles, occupation doses can be easily maintained far below regulatory limits and maintained ALARA.

AHRQ series paper 2: principles for developing guidance: AHRQ and the effective health-care program.

PubMed

Helfand, Mark; Balshem, Howard

2010-05-01

This article describes some of the fundamental principles that have been developed to guide the work of producing comparative effectiveness reviews (CERs). We briefly describe the role stakeholders play in providing important insights that inform the evidence-gathering process, and discuss the critical role of analytic frameworks in illuminating the relationship between surrogate measures and health outcomes, providing an understanding of the context in which clinical decisions are made and the uncertainties that underlie clinical controversies. We describe the Effective Health Care program conceptual model for considering different types of evidence that emphasizes minimizing the risk of bias, but places high-quality, highly applicable evidence about effectiveness at the top of the hierarchy. Finally, we briefly describe areas of future methodological research. CERs have become a foundation for decision-making in clinical practice and health policy. To be useful, CERs must approach the evidence from a patient-centered perspective; explore the clinical logic underlying the rationale for a service; cast a broad net with respect to types of evidence, placing a high value on effectiveness and applicability, in addition to internal validity; and, present benefits and harms for treatments and tests in a consistent way.

Humidity Sensors Principle, Mechanism, and Fabrication Technologies: A Comprehensive Review

PubMed Central

Farahani, Hamid; Wagiran, Rahman; Hamidon, Mohd Nizar

2014-01-01

Humidity measurement is one of the most significant issues in various areas of applications such as instrumentation, automated systems, agriculture, climatology and GIS. Numerous sorts of humidity sensors fabricated and developed for industrial and laboratory applications are reviewed and presented in this article. The survey frequently concentrates on the RH sensors based upon their organic and inorganic functional materials, e.g., porous ceramics (semiconductors), polymers, ceramic/polymer and electrolytes, as well as conduction mechanism and fabrication technologies. A significant aim of this review is to provide a distinct categorization pursuant to state of the art humidity sensor types, principles of work, sensing substances, transduction mechanisms, and production technologies. Furthermore, performance characteristics of the different humidity sensors such as electrical and statistical data will be detailed and gives an added value to the report. By comparison of overall prospects of the sensors it was revealed that there are still drawbacks as to efficiency of sensing elements and conduction values. The flexibility offered by thick film and thin film processes either in the preparation of materials or in the choice of shape and size of the sensor structure provides advantages over other technologies. These ceramic sensors show faster response than other types. PMID:24784036

Open Marketplace for Simulation Software on the Basis of a Web Platform

NASA Astrophysics Data System (ADS)

Kryukov, A. P.; Demichev, A. P.

2016-02-01

The focus in development of a new generation of middleware shifts from the global grid systems to building convenient and efficient web platforms for remote access to individual computing resources. Further line of their development, suggested in this work, is related not only with the quantitative increase in their number and with the expansion of scientific, engineering, and manufacturing areas in which they are used, but also with improved technology for remote deployment of application software on the resources interacting with the web platforms. Currently, the services for providers of application software in the context of scientific-oriented web platforms is not developed enough. The proposed in this work new web platforms of application software market should have all the features of the existing web platforms for submissions of jobs to remote resources plus the provision of specific web services for interaction on market principles between the providers and consumers of application packages. The suggested approach will be approved on the example of simulation applications in the field of nonlinear optics.

Acoustic emission and nondestructive evaluation of biomaterials and tissues.

PubMed

Kohn, D H

1995-01-01

Acoustic emission (AE) is an acoustic wave generated by the release of energy from localized sources in a material subjected to an externally applied stimulus. This technique may be used nondestructively to analyze tissues, materials, and biomaterial/tissue interfaces. Applications of AE include use as an early warning tool for detecting tissue and material defects and incipient failure, monitoring damage progression, predicting failure, characterizing failure mechanisms, and serving as a tool to aid in understanding material properties and structure-function relations. All these applications may be performed in real time. This review discusses general principles of AE monitoring and the use of the technique in 3 areas of importance to biomedical engineering: (1) analysis of biomaterials, (2) analysis of tissues, and (3) analysis of tissue/biomaterial interfaces. Focus in these areas is on detection sensitivity, methods of signal analysis in both the time and frequency domains, the relationship between acoustic signals and microstructural phenomena, and the uses of the technique in establishing a relationship between signals and failure mechanisms.

Developing a quality assurance program for online services.

PubMed Central

Humphries, A W; Naisawald, G V

1991-01-01

A quality assurance (QA) program provides not only a mechanism for establishing training and competency standards, but also a method for continuously monitoring current service practices to correct shortcomings. The typical QA cycle includes these basic steps: select subject for review, establish measurable standards, evaluate existing services using the standards, identify problems, implement solutions, and reevaluate services. The Claude Moore Health Sciences Library (CMHSL) developed a quality assurance program for online services designed to evaluate services against specific criteria identified by research studies as being important to customer satisfaction. These criteria include reliability, responsiveness, approachability, communication, and physical factors. The application of these criteria to the library's existing online services in the quality review process is discussed with specific examples of the problems identified in each service area, as well as the solutions implemented to correct deficiencies. The application of the QA cycle to an online services program serves as a model of possible interventions. The use of QA principles to enhance online service quality can be extended to other library service areas. PMID:1909197

Developing a quality assurance program for online services.

PubMed

Humphries, A W; Naisawald, G V

1991-07-01

A quality assurance (QA) program provides not only a mechanism for establishing training and competency standards, but also a method for continuously monitoring current service practices to correct shortcomings. The typical QA cycle includes these basic steps: select subject for review, establish measurable standards, evaluate existing services using the standards, identify problems, implement solutions, and reevaluate services. The Claude Moore Health Sciences Library (CMHSL) developed a quality assurance program for online services designed to evaluate services against specific criteria identified by research studies as being important to customer satisfaction. These criteria include reliability, responsiveness, approachability, communication, and physical factors. The application of these criteria to the library's existing online services in the quality review process is discussed with specific examples of the problems identified in each service area, as well as the solutions implemented to correct deficiencies. The application of the QA cycle to an online services program serves as a model of possible interventions. The use of QA principles to enhance online service quality can be extended to other library service areas.

Measurement of infiltration rates in urban sewer systems by use of oxygen isotopes.

PubMed

De Bénédittis, J; Bertrand-Krajewski, J L

2005-01-01

The paper presents the principle of a method to measure infiltration rates in sewer systems based on the use of oxygen isotopes and its application in Lyon (France). In the urban area of Lyon, significant differences in delta 18O that can reach 3 per thousand are observed between the oxygen isotopic compositions of groundwater originating from Rhone, Saone and from their associated alluvial aquifers. Drinking water supplying Lyon results mainly from pumping in the Rhone alluvial aquifer. Therefore, in some areas, the difference of isotopic composition between wastewater resulting from the consumption of drinking water and local groundwater can be used to measure infiltration in sewer systems. The application in the catchment of Ecully shows that the infiltration flow rate presents strong fluctuations at an hourly scale: it varies between 15 and 40 m3/h. This variability could be explained by non-constant discharges of pumping and by variations of the water level in the sewer.

15 CFR 295.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... in accordance with applicable Federal cost principles. (e) The term foreign-owned company means a... allowability of indirect costs in accordance with applicable Federal cost principles. (i) The term industry-led..., marketing, or distribution of any product, process, or service that is not reasonably required to conduct...

Dielectric elastomers: from the beginning of modern science to applications in actuators and energy harvesters

NASA Astrophysics Data System (ADS)

Baumgartner, Richard; Keplinger, Christoph; Kaltseis, Rainer; Schwödiauer, Reinhard; Bauer, Siegfried

2011-04-01

Electrically deformable materials have a long history, with first quotations in a letter from Alessandro Volta. The topic turned out to be hot at the end of the 19th century, with a landmark paper of Röntgen anticipating the dielectric elastomer principle. In 2000, Pelrine and co-workers generated huge interest in such soft actuators, by demonstrating voltage induced huge area expansion rates of more than 300%. Since then, the field became mature, with first commercial applications appearing on the market. New frontiers also emerged recently, for example by using dielectric transducers in a reverse mode for scavenging mechanical energy. In the present survey we briefly discuss the latest developments in the field.

Statistical design of quantitative mass spectrometry-based proteomic experiments.

PubMed

Oberg, Ann L; Vitek, Olga

2009-05-01

We review the fundamental principles of statistical experimental design, and their application to quantitative mass spectrometry-based proteomics. We focus on class comparison using Analysis of Variance (ANOVA), and discuss how randomization, replication and blocking help avoid systematic biases due to the experimental procedure, and help optimize our ability to detect true quantitative changes between groups. We also discuss the issues of pooling multiple biological specimens for a single mass analysis, and calculation of the number of replicates in a future study. When applicable, we emphasize the parallels between designing quantitative proteomic experiments and experiments with gene expression microarrays, and give examples from that area of research. We illustrate the discussion using theoretical considerations, and using real-data examples of profiling of disease.

High-precision control of LSRM based X-Y table for industrial applications.

PubMed

Pan, J F; Cheung, Norbert C; Zou, Yu

2013-01-01

The design of an X-Y table applying direct-drive linear switched reluctance motor (LSRM) principle is proposed in this paper. The proposed X-Y table has the characteristics of low cost, simple and stable mechanical structure. After the design procedure is introduced, an adaptive position control method based on online parameter identification and pole-placement regulation scheme is developed for the X-Y table. Experimental results prove the feasibility and its priority over a traditional PID controller with better dynamic response, static performance and robustness to disturbances. It is expected that the novel two-dimensional direct-drive system find its applications in high-precision manufacture area. Copyright © 2012 ISA. Published by Elsevier Ltd. All rights reserved.

[Principles for the evaluation of telemedicine applications: Results of a systematic review and consensus process].

PubMed

Arnold, Katrin; Scheibe, Madlen; Müller, Olaf; Schmitt, Jochen

2016-11-01

The limited number of telemedicine applications being transferred to standard medical care in Germany may to some extent be explained by deficits in the current evaluation practice. Effectiveness and cost effectiveness can only be demonstrated to decision makers and potential users with methodologically sound and fully published evaluations. There is a lack of well-founded and mandatory standards for adequate, comparable evaluations of telemedicine applications. As part of the project CCS Telehealth Eastern Saxony (CCS THOS), a systematic review on evaluation concepts for telemedicine applications (search period until September 2014, databases Medline, Embase, HTA-Database, DARE, NHS EED) as well as an additional selective literature search were conducted. Suggestions for evaluation fundamentals were derived from the results. These suggestions were subjected to a formal consensus process (nominal group process) with relevant stakeholder groups (healthcare payers, healthcare providers, health policy representatives, researchers). 19 papers were included in the systematic review. In accordance with the predefined inclusion criteria, each presented an evaluation concept for telemedicine applications that was based upon a systematic review and/or a consensus process. Via a formal consensus process, the suggestions for evaluation principles derived from the review and the selective literature search (23 papers) resulted in ten agreed evaluation principles. Eight of them were unanimously agreed upon, two were arrived at with one abstention each. The principles enclose criteria for the planning, conduct and reporting of telemedicine evaluations. Adherence to them is obligatory for users of the telemedical infrastructure provided by CCS THOS. Furthermore, right from the beginning the intention was very much for these principles to be seized upon by other projects and initiatives. The agreed evaluation principles for telemedicine applications are the first in Germany to be based both upon evidence and consensus. Due to the methodology of development, they have a strong scientific and health policy legitimation. Therefore, and because of their general applicability, adherence to these principles beyond the context of the telemedicine platform developed within CCS THOS is recommended, namely throughout the German telemedicine scene. Copyright © 2016. Published by Elsevier GmbH.

Basic hydraulic principles of open-channel flow

USGS Publications Warehouse

Jobson, Harvey E.; Froehlich, David C.

1988-01-01

The three basic principles of open-channel-flow analysis--the conservation of mass, energy, and momentum--are derived, explained, and applied to solve problems of open-channel flow. These principles are introduced at a level that can be comprehended by a person with an understanding of the principles of physics and mechanics equivalent to that presented in the first college level course of the subject. The reader is assumed to have a working knowledge of algebra and plane geometry as well as some knowledge of calculus. Once the principles have been derived, a number of example applications are presented that illustrate the computation of flow through culverts and bridges, and over structures, such as dams and weirs. Because resistance to flow is a major obstacle to the successful application of the energy principle to open-channel flow, procedures are outlined for the rational selection of flow resistance coefficients. The principle of specific energy is shown to be useful in the prediction of water-surface profiles both in the qualitative and quantitative sense. (USGS)

Using Adult Learning Principles in Adult Basic and Literacy Education. Practice Application Brief.

ERIC Educational Resources Information Center

Imel, Susan

Adult basic and literacy education (ABLE) is a complex undertaking that serves diverse learners with a variety of needs. Although no definitive list of adult education principles exists in the literature, the following principles have been identified in multiple sources devoted to principles of effective adult education: involve learners in…

Applicability of the independence principle to subsonic turbulent flow over a swept rearward-facing step

NASA Technical Reports Server (NTRS)

Selby, G. V.

1983-01-01

Prandtl (1946) has concluded that for yawed laminar incompressible flows the streamwise flow is independent of the spanwise flow. However, Ashkenas and Riddell (1955) have reported that for turbulent flow the 'independence principle' does not apply to yawed flat plates. On the other hand, it was also found that this principle may be applicable to many turbulent flows. As the sweep angle is increased, a sweep angle is reached which defines the interval over which the 'independence principle' is valid. The results obtained in the present investigation indicate the magnitude of the critical angle for subsonic turbulent flow over a swept rearward-facing step.

Nursing application of Bobath principles in stroke care.

PubMed

Passarella, P M; Lewis, N

1987-04-01

The nursing approach in the care of stroke patients has a direct impact on functional outcome. Nursing application of Bobath principles in stroke care offers a nursing focus on involvement of the affected side; facilitation of normal tone, posture, and movement; and development of more normal function. A research study evaluating the functional gains of stroke patients demonstrated a significant level of functional improvement in those treated with Bobath principles over stroke patients treated with the traditional nursing approach. Practical methods for applying Bobath principles in patient care activities are described. These therapeutic methods provide nurses with the means to maximize stroke patients' potential and further influence their functional recovery.

A Phenomenological Investigation of Rural Superintendents' Experiences in the Application of Principle-Centered Leadership

ERIC Educational Resources Information Center

Davidson, Shelby L.

2015-01-01

This qualitative phenomenological research study used narrative inquiry to investigate rural superintendents' experiences with the application of principle-centered leadership in their districts. Ten superintendents from rural districts in east Texas were interviewed. Narratives were analyzed by organizing, describing, classifying, and…

Integrating long-offset transient electromagnetics (LOTEM) with seismics in an exploration environment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Strack, K.M.; Vozoff, K.

The applications of electromagnetics have increased in the past two decades because of an improved understanding of the methods, improves service availability, and the increased focus of exploration in the more complex reservoir characterization issues. For electromagnetic methods surface applications for hydrocarbon Exploration and Production are still a special case, while applications in borehole and airborne research and for engineering and environmental objectives are routine. In the past, electromagnetic techniques, in particular deep transient electromagnetics, made up a completely different discipline in geophysics, although many of the principles are similar to the seismic one. With an understanding of the specificmore » problems related to data processing initially and then acquisition, the inclusion of principles learned from seismics happened almost naturally. Initially, the data processing was very similar to seismic full-waveform processing. The hardware was also changed to include multichannel acquisition systems, and the field procedures became very similar to seismic surveying. As a consequence, the integration and synergism of the interpretation process is becoming almost automatic. The long-offset transient electromagnetic (LOTEM) technique will be summarized from the viewpoint of its similarity to seismics. The complete concept of the method will also be reviewed. An interpretation case history that integrates seismic and LOTEM from a hydrocarbon area in China clearly demonstrates the limitations and benefits of the method.« less

TMS-EEG: From basic research to clinical applications

NASA Astrophysics Data System (ADS)

Hernandez-Pavon, Julio C.; Sarvas, Jukka; Ilmoniemi, Risto J.

2014-11-01

Transcranial magnetic stimulation (TMS) combined with electroencephalography (EEG) is a powerful technique for non-invasively studying cortical excitability and connectivity. The combination of TMS and EEG has widely been used to perform basic research and recently has gained importance in different clinical applications. In this paper, we will describe the physical and biological principles of TMS-EEG and different applications in basic research and clinical applications. We will present methods based on independent component analysis (ICA) for studying the TMS-evoked EEG responses. These methods have the capability to remove and suppress large artifacts, making it feasible, for instance, to study language areas with TMS-EEG. We will discuss the different applications and limitations of TMS and TMS-EEG in clinical applications. Potential applications of TMS are presented, for instance in neurosurgical planning, depression and other neurological disorders. Advantages and disadvantages of TMS-EEG and its variants such as repetitive TMS (rTMS) are discussed in comparison to other brain stimulation and neuroimaging techniques. Finally, challenges that researchers face when using this technique will be summarized.

50 CFR 23.65 - What factors are considered in making a finding that an applicant is suitably equipped to house...

Code of Federal Regulations, 2011 CFR

2011-10-01

... finding that an applicant is suitably equipped to house and care for a live specimen? 23.65 Section 23.65... an applicant is suitably equipped to house and care for a live specimen? (a) Purpose. Under Article... house and care for them. (b) General principles. We will follow these general principles in making a...

49 CFR 212.101 - Program principles.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Program principles. 212.101 Section 212.101 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... principles. (a) The purpose of the national railroad safety program is to promote safety in all areas of...

36 CFR 213.1 - Designation, administration, and development of National Grasslands.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Tenant Act. (c) The National Grasslands shall be administered under sound and progressive principles of...-yield management of the forage, fish and wildlife, timber, water and recreational resources in the areas... and practical principles of land use for the areas in which they are located. The Chief of the Forest...

10 CFR 600.222 - Allowable costs.

Code of Federal Regulations, 2010 CFR

2010-01-01

... part 31. Contract Cost Principles and Procedures, or uniform cost accounting standards that comply with... OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES Uniform Administrative...) Applicable cost principles. For each kind of organization, there is a set of Federal principles for...

7 CFR 1770.26 - General.

Code of Federal Regulations, 2010 CFR

2010-01-01

... methods and principles of accounting prescribed by the state regulatory body having jurisdiction over the... telecommunications companies (47 CFR part 32), as those methods and principles of accounting are supplemented from... instruments by prescribing accounting principles, methodologies, and procedures applicable to all...

On using ethical principles of community-engaged research in translational science.

PubMed

Khodyakov, Dmitry; Mikesell, Lisa; Schraiber, Ron; Booth, Marika; Bromley, Elizabeth

2016-05-01

The transfer of new discoveries into both clinical practice and the wider community calls for reliance on interdisciplinary translational teams that include researchers with different areas of expertise, representatives of health care systems and community organizations, and patients. Engaging new stakeholders in research, however, calls for a reconsideration or expansion of the meaning of ethics in translational research. We explored expert opinion on the applicability of ethical principles commonly practiced in community-engaged research (CEnR) to translational research. To do so, we conducted 2 online, modified-Delphi panels with 63 expert stakeholders who iteratively rated and discussed 9 ethical principles commonly used in CEnR in terms of their importance and feasibility for use in translational research. The RAND/UCLA appropriateness method was used to analyze the data and determine agreement and disagreement among participating experts. Both panels agreed that ethical translational research should be "grounded in trust." Although the academic panel endorsed "culturally appropriate" and "forthcoming with community about study risks and benefits," the mixed academic-community panel endorsed "scientifically valid" and "ready to involve community in interpretation and dissemination" as important and feasible principles of ethical translational research. These findings suggest that in addition to protecting human subjects, contemporary translational science models need to account for the interests of, and owe ethical obligations to, members of the investigative team and the community at large. Copyright © 2016 Elsevier Inc. All rights reserved.

Ethical principles and the rationing of health care: a qualitative study in general practice

PubMed Central

Berney, Lee; Kelly, Moira; Doyal, Len; Feder, Gene; Griffiths, Chris; Jones, Ian Rees

2005-01-01

Background Researching sensitive topics, such as the rationing of treatments and denial of care, raises a number of ethical and methodological problems. Aim To describe the methods and findings from a number of focus group discussions that examined how GPs apply ethical principles when allocating scarce resources. Design of study A small-scale qualitative study involving purposive sampling, semi-structured interviews and focus groups. Setting Twenty-four GPs from two contrasting areas of London: one relatively affluent and one relatively deprived. Method Initial interviews asked GPs to identify key resource allocation issues. The interviews were transcribed and themes were identified. A number of case studies, each illustrative of an ethical issue related to rationing, were written up in the form of vignettes. In focus group discussions, GPs were given a number of these vignettes to debate. Results With respect to the ethical basis for decision making, the findings from this part of the study emphasised the role of social and psychological factors, the influence of the quality of the relationship between GPs and patients and confusion among GPs about their role in decision making. Conclusion The use of vignettes developed from prior interviews with GPs creates a non-threatening environment to discuss sensitive or controversial issues. The acceptance by GPs of general moral principles does not entail clarity of coherence of the application of these principles in practice. PMID:16105371

On Using Ethical Principles of Community-Engaged Research in Translational Science

PubMed Central

Mikesell, Lisa; Schraiber, Ron; Booth, Marika; Bromley, Elizabeth

2015-01-01

The transfer of new discoveries into both clinical practice and the wider community calls for reliance on interdisciplinary translational teams that include researchers with different areas of expertise, representatives of healthcare systems and community organizations, and patients. Engaging new stakeholders in research, however, calls for a re-consideration or expansion of the meaning of ethics in translational research. We explored expert opinion on the applicability of ethical principles commonly practiced in community-engaged research (CEnR) to translational research. To do so, we conducted two online, modified-Delphi panels with 63 expert stakeholders who iteratively rated and discussed nine ethical principles commonly used in CEnR in terms of their importance and feasibility for use in translational research. The RAND/UCLA Appropriateness Method was used to analyze the data and determine agreement and disagreement among participating experts. Both panels agreed that ethical translational research should be “grounded in trust.” While the academic panel endorsed “culturally appropriate” and “forthcoming with community about study risks and benefits,” the mixed academic-community panel endorsed “scientifically valid” and “ready to involve community in interpretation and dissemination” as important and feasible principles of ethical translational research. These findings suggest that in addition to protecting human subjects, contemporary translational science models need to account for the interests of, and owe ethical obligations to, members of the investigative team and the community at large. PMID:26773561

Structural principles for computational and de novo design of 4Fe-4S metalloproteins

PubMed Central

Nanda, Vikas; Senn, Stefan; Pike, Douglas H.; Rodriguez-Granillo, Agustina; Hansen, Will; Khare, Sagar D.; Noy, Dror

2017-01-01

Iron-sulfur centers in metalloproteins can access multiple oxidation states over a broad range of potentials, allowing them to participate in a variety of electron transfer reactions and serving as catalysts for high-energy redox processes. The nitrogenase FeMoCO cluster converts di-nitrogen to ammonia in an eight-electron transfer step. The 2(Fe4S4) containing bacterial ferredoxin is an evolutionarily ancient metalloprotein fold and is thought to be a primordial progenitor of extant oxidoreductases. Controlling chemical transformations mediated by iron-sulfur centers such as nitrogen fixation, hydrogen production as well as electron transfer reactions involved in photosynthesis are of tremendous importance for sustainable chemistry and energy production initiatives. As such, there is significant interest in the design of iron-sulfur proteins as minimal models to gain fundamental understanding of complex natural systems and as lead-molecules for industrial and energy applications. Herein, we discuss salient structural characteristics of natural iron-sulfur proteins and how they guide principles for design. Model structures of past designs are analyzed in the context of these principles and potential directions for enhanced designs are presented, and new areas of iron-sulfur protein design are proposed. PMID:26449207

Using Green Chemistry and Engineering Principles to Design ...

EPA Pesticide Factsheets

The concepts of green chemistry and engineering (GC&E) have been promoted as an effective qualitative framework for developing more sustainable chemical syntheses, processes, and material management techniques. This has been demonstrated by many theoretical and practical cases. In addition, there are several approaches and frameworks focused on demonstrating that improvements were achieved through GC&E technologies. However, the application of these principles is not always straightforward. We propose using systematic frameworks and tools that help practitioners when deciding which principles can be applied, the levels of implementation, prospective of obtaining simultaneous improvements in all sustainability aspects, and ways to deal with multiobjective problems. Therefore, this contribution aims to provide a systematic combination of three different and complementary design tools for assisting designers in evaluating, developing, and improving chemical manufacturing and material management systems under GC&E perspectives. The WAR Algorithm, GREENSCOPE, and SustainPro were employed for this synergistic approach of incorporating sustainability at early stages of process development. In this demonstration, simulated ammonia production is used as a case study to illustrate this advancement. Results show how to identify process design areas for improvements, key factors, multi-criteria decision-making solutions, and optimal tradeoffs. Finally, conclusions were pre

Electromembrane extraction--three-phase electrophoresis for future preparative applications.

PubMed

Gjelstad, Astrid; Pedersen-Bjergaard, Stig

2014-09-01

The purpose of this article is to discuss the principle and the future potential for electromembrane extraction (EME). EME was presented in 2006 as a totally new sample preparation technique for ionized target analytes, based on electrokinetic migration across a supported liquid membrane under the influence of an external electrical field. The principle of EME is presented, and typical performance data for EME are discussed. Most work with EME up to date has been performed with low-molecular weight pharmaceutical substances as model analytes, but the principles of EME should be developed in other directions in the future to fully explore the potential. Recent research in new directions is critically reviewed, with focus on extraction of different types of chemical and biochemical substances, new separation possibilities, new approaches, and challenges related to mass transfer and background current. The intention of this critical review is to give a flavor of EME and to stimulate into more research in the area of EME. Unlike other review articles, the current one is less comprehensive, but put more emphasis on new directions for EME. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

The Application of Artificial Intelligence Principles to Teaching and Training

ERIC Educational Resources Information Center

Shaw, Keith

2008-01-01

This paper compares and contrasts the use of AI principles in industrial training with more normal computer-based training (CBT) approaches. A number of applications of CBT are illustrated (for example simulations, tutorial presentations, fault diagnosis, management games, industrial relations exercises) and compared with an alternative approach…

Teaching Economic Principles Interactively: A Cannibal's Dinner Party

ERIC Educational Resources Information Center

Bergstrom, Theodore C.

2009-01-01

The author describes techniques that he uses to interactively teach economics principles. He describes an experiment on market entry and gives examples of applications of classroom clickers. Clicker applications include (a) collecting data about student preferences that can be used to construct demand curves and supply curves, (b) checking…

77 FR 27015 - Announcement of Grant and Loan Application Deadlines and Funding Levels

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-08

... principles and general administrative requirements for grants pertaining to their organizational type in..., interest rates, terms, and collateral requirements. (5) Provide a marketing plan. (6) Explain the mechanics... figures to the nearest dollar. Applicants should consult OMB Circular A-122: ``Cost Principles for Non...

17 CFR Appendix A to Part 39 - Application Guidance and Compliance With Core Principles

Code of Federal Regulations, 2011 CFR

2011-04-01

... carrying out the clearing organization's risk management program. In addressing Core Principle M... further the objectives of the clearing organization's risk management program and any of its surveillance... TRADING COMMISSION DERIVATIVES CLEARING ORGANIZATIONS Pt. 39, App. A Appendix A to Part 39—Application...

The Application of Tissue Engineering Procedures to Repair the Larynx

ERIC Educational Resources Information Center

Ringel, Robert L.; Kahane, Joel C.; Hillsamer, Peter J.; Lee, Annie S.; Badylak, Stephen F.

2006-01-01

The field of tissue engineering/regenerative medicine combines the quantitative principles of engineering with the principles of the life sciences toward the goal of reconstituting structurally and functionally normal tissues and organs. There has been relatively little application of tissue engineering efforts toward the organs of speech, voice,…

TQM Reaches the Academy.

ERIC Educational Resources Information Center

Marchese, Ted

1991-01-01

This introduction to the application of Total Quality Management (TQM) on college campuses first reviews the development and application of TQM principles in Japanese industries and recent implementation in industries and the Federal Government in the United States. Twelve principles of TQM are then identified: (1) a focus on quality; (2)…

2 CFR 220.20 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Applicability. 220.20 Section 220.20 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET CIRCULARS AND GUIDANCE Reserved COST PRINCIPLES FOR... of Appendix A to this part in determining the costs incurred for such work. The principles shall also...

24 CFR 1003.501 - Applicability of uniform administrative requirements and cost principles.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 4 2011-04-01 2011-04-01 false Applicability of uniform administrative requirements and cost principles. 1003.501 Section 1003.501 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND...

Clinical Application Projects (CAPs) for Health Science Students in Introductory Microbiology.

ERIC Educational Resources Information Center

Halyard, Rebecca A.

Clinical Application Projects (CAPs) have been developed that allow dental hygiene and nursing students to apply introductory microbiology principles and skills learned in lecture and laboratory to a problem in an appropriate clinical situation. CAPs therefore substitute for the traditional study of "unknowns". Principles and processes emphasized…

29 CFR 776.22b - Guiding principles.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Individual Employee Coverage in the Construction Industry § 776.22b Guiding principles. (a) Scope of bulletin... and Hour Division with respect to the applicability of the Fair Labor Standards Act to employees... application dependent on the character of an employee's activities, that is, on whether he is engaged “in...

29 CFR 776.22b - Guiding principles.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Individual Employee Coverage in the Construction Industry § 776.22b Guiding principles. (a) Scope of bulletin... and Hour Division with respect to the applicability of the Fair Labor Standards Act to employees... application dependent on the character of an employee's activities, that is, on whether he is engaged “in...

Basic principles of variable speed drives

NASA Technical Reports Server (NTRS)

Loewenthal, S. H.

1973-01-01

An understanding of the principles which govern variable speed drive operation is discussed for successful drive application. The fundamental factors of torque, speed ratio, and power as they relate to drive selection are discussed. The basic types of variable speed drives, their operating characteristics and their applications are also presented.

How bioethics principles can aid design of electronic health records to accommodate patient granular control.

PubMed

Meslin, Eric M; Schwartz, Peter H

2015-01-01

Ethics should guide the design of electronic health records (EHR), and recognized principles of bioethics can play an important role. This approach was recently adopted by a team of informaticists who are designing and testing a system where patients exert granular control over who views their personal health information. While this method of building ethics in from the start of the design process has significant benefits, questions remain about how useful the application of bioethics principles can be in this process, especially when principles conflict. For instance, while the ethical principle of respect for autonomy supports a robust system of granular control, the principles of beneficence and nonmaleficence counsel restraint due to the danger of patients being harmed by restrictions on provider access to data. Conflict between principles has long been recognized by ethicists and has even motivated attacks on approaches that state and apply principles. In this paper, we show how using ethical principles can help in the design of EHRs by first explaining how ethical principles can and should be used generally, and then by discussing how attention to details in specific cases can show that the tension between principles is not as bad as it initially appeared. We conclude by suggesting ways in which the application of these (and other) principles can add value to the ongoing discussion of patient involvement in their health care. This is a new approach to linking principles to informatics design that we expect will stimulate further interest.

Recent Advances of Solution-Processed Metal Oxide Thin-Film Transistors.

PubMed

Xu, Wangying; Li, Hao; Xu, Jian-Bin; Wang, Lei

2018-03-06

Solution-processed metal oxide thin-film transistors (TFTs) are considered as one of the most promising transistor technologies for future large-area flexible electronics. This review surveys the recent advances in solution-based oxide TFTs, including n-type oxide semiconductors, oxide dielectrics and p-type oxide semiconductors. Firstly, we provide an introduction on oxide TFTs and the TFT configurations and operating principles. Secondly, we present the recent progress in solution-processed n-type transistors, with a special focus on low-temperature and large-area solution processed approaches as well as novel non-display applications. Thirdly, we give a detailed analysis of the state-of-the-art solution-processed oxide dielectrics for low-voltage electronics. Fourthly, we discuss the recent progress in solution-based p-type oxide semiconductors, which will enable the highly desirable future low-cost large-area complementary circuits. Finally, we draw the conclusions and outline the perspectives over the research field.

78 FR 79444 - Loveland Area Projects-2025 Power Marketing Initiative

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-30

... extends the current marketing plan, with amendments to key marketing plan principles. Western's proposed..., 1986) and provided the marketing plan principles used to market LAP firm hydropower resources. The FES.... The meetings provided customers the opportunity to review current marketing plan principles and...

28 CFR 66.22 - Allowable costs.

Code of Federal Regulations, 2010 CFR

2010-07-01

... part 31. Contract Cost Principles and Procedures, or uniform cost accounting standards that comply with... AND COOPERATIVE AGREEMENTS TO STATE AND LOCAL GOVERNMENTS Post-Award Requirements Financial...) Applicable cost principles. For each kind of organization, there is a set of Federal principles for...

Ethical Principles of Psychologists and Code of Conduct.

ERIC Educational Resources Information Center

American Psychologist, 2002

2002-01-01

Describes the American Psychological Association's Ethical Principles of Psychologists and Code of Conduct, focusing on introduction and applicability; preamble; general principles; and ethical standards (resolving ethical issues, competence, human relations, privacy and confidentiality, advertising and other public statements, record keeping and…

45 CFR 2541.220 - Allowable costs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... accounting standards that comply with cost principles acceptable to the Federal agency. ... the grantee or subgrantee. (b) Applicable cost principles. For each kind of organization, there is a set of Federal principles for determining allowable costs. Allowable costs will be determined in...

43 CFR 12.62 - Allowable costs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... uniform cost accounting standards that comply with cost principles acceptable to the Federal agency. ... COST PRINCIPLES FOR ASSISTANCE PROGRAMS Uniform Administrative Requirements for Grants and Cooperative... increment above allowable costs) to the grantee or subgrantee. (b) Applicable cost principles. For each kind...

Computer-assisted map projection research

USGS Publications Warehouse

Snyder, John Parr

1985-01-01

Computers have opened up areas of map projection research which were previously too complicated to utilize, for example, using a least-squares fit to a very large number of points. One application has been in the efficient transfer of data between maps on different projections. While the transfer of moderate amounts of data is satisfactorily accomplished using the analytical map projection formulas, polynomials are more efficient for massive transfers. Suitable coefficients for the polynomials may be determined more easily for general cases using least squares instead of Taylor series. A second area of research is in the determination of a map projection fitting an unlabeled map, so that accurate data transfer can take place. The computer can test one projection after another, and include iteration where required. A third area is in the use of least squares to fit a map projection with optimum parameters to the region being mapped, so that distortion is minimized. This can be accomplished for standard conformal, equalarea, or other types of projections. Even less distortion can result if complex transformations of conformal projections are utilized. This bulletin describes several recent applications of these principles, as well as historical usage and background.

[Pay attention to the standardized application of new techniques in surgical treatment of thyroid disease].

PubMed

Tian, W; Xi, H Q; Wang, B

2017-08-01

The continuous development and application of new technology in thyroid surgery has promoted the rapid improvement of thyroid surgery. New technology in the field of thyroid surgery has developed rapidly. The application of neural monitoring technology has enabled the thyroid surgery to enter an accurate era. Imtraoperative neuromonitoring and continuous intraoperative neuromonitoring have made the recurrent laryngeal nerve protection more secure. Nano-carbon parathyroid gland negative imaging technology could identify parathyroid gland more precise. However, when the nano-carbon was used, the injection time, position and dosage should be grasped so as to achieve the best effect of negative imaging. Endoscopic and robotic thyroid surgery could meet the demand of cosmetic. "Treatment first, beauty second" is still the principle to be strictly followed. Do not blindly expand indications and pursue endoscopic surgery. Energy surgical instruments' update made the operation more efficient, while the instruments have some disadvantages. Thyroid surgeon must correctly understand the working principle of new energy devices and use them rationally. Through grasping the working principle and application skills of new technology in clinical work, definiting its advantages and disadvantages, adhereing to the "reasonable choice, standard application" principle, learning the pioneers' experience, the application of new thyroid diagnosis and treatment technology could be more reasonable and safe.

Contextualizing the Physician Charter on Professionalism in Qatar: From Patient Autonomy to Family Autonomy

PubMed Central

Ho, Ming-Jung; Alkhal, Abdullatif; Tekian, Ara; Shih, Julie; Shaw, Kevin; Wang, Chung-Hsiang; Alyafei, Khalid; Konopasek, Lyuba

2016-01-01

Background  The Physician Charter on medical professionalism has been endorsed by professional organizations worldwide, yet it is unclear if this Western framework of professionalism is applicable in non-Western countries. Objective  This study examines how physicians practicing in a Middle Eastern context perceive the terms, principles, and commitments outlined in the charter. Methods  In May 2013, the authors conducted 6 focus groups with 43 clinician-educators practicing at Hamad Medical Corporation in Doha, Qatar, to discuss the applicability of the Physician Charter in a local context. The research team coded and analyzed transcripts to identify sociocultural influences on professionalism. Results  Participants generally expressed agreement with the applicability of the charter's principles to physician professionalism in Qatar. However, 3 contextual factors (religious beliefs and practices, family-centered decision making, and multinationality) complicated the application of the core principles of patient autonomy and social justice. Islamic beliefs reinforced the importance of professional values such as altruism, but presented a barrier to the principle of self-determination for female patients. The family-centered culture in Qatar called for enlarging the scope of patient-centered decision making to include the patient's family. Qatar's multinational population prompted debate over equal treatment and how to conceptualize and implement the principle of social justice. Conclusions  Several sociocultural contexts influence the conceptualization of the principles of medical professionalism in Qatar. The findings suggest that contextual factors should be considered when developing or adopting a professionalism framework in an international setting and context. PMID:28018537

Contextualizing the Physician Charter on Professionalism in Qatar: From Patient Autonomy to Family Autonomy.

PubMed

Ho, Ming-Jung; Alkhal, Abdullatif; Tekian, Ara; Shih, Julie; Shaw, Kevin; Wang, Chung-Hsiang; Alyafei, Khalid; Konopasek, Lyuba

2016-12-01

The Physician Charter on medical professionalism has been endorsed by professional organizations worldwide, yet it is unclear if this Western framework of professionalism is applicable in non-Western countries. This study examines how physicians practicing in a Middle Eastern context perceive the terms, principles, and commitments outlined in the charter. In May 2013, the authors conducted 6 focus groups with 43 clinician-educators practicing at Hamad Medical Corporation in Doha, Qatar, to discuss the applicability of the Physician Charter in a local context. The research team coded and analyzed transcripts to identify sociocultural influences on professionalism. Participants generally expressed agreement with the applicability of the charter's principles to physician professionalism in Qatar. However, 3 contextual factors (religious beliefs and practices, family-centered decision making, and multinationality) complicated the application of the core principles of patient autonomy and social justice. Islamic beliefs reinforced the importance of professional values such as altruism, but presented a barrier to the principle of self-determination for female patients. The family-centered culture in Qatar called for enlarging the scope of patient-centered decision making to include the patient's family. Qatar's multinational population prompted debate over equal treatment and how to conceptualize and implement the principle of social justice. Several sociocultural contexts influence the conceptualization of the principles of medical professionalism in Qatar. The findings suggest that contextual factors should be considered when developing or adopting a professionalism framework in an international setting and context.

QCM-D study of nanoparticle interactions.

PubMed

Chen, Qian; Xu, Shengming; Liu, Qingxia; Masliyah, Jacob; Xu, Zhenghe

2016-07-01

Quartz crystal microbalance with dissipation monitoring (QCM-D) has been proven to be a powerful research tool to investigate in situ interactions between nanoparticles and different functionalized surfaces in liquids. QCM-D can also be used to quantitatively determine adsorption kinetics of polymers, DNA and proteins from solutions on various substrate surfaces while providing insights into conformations of adsorbed molecules. This review aims to provide a comprehensive overview on various important applications of QCM-D, focusing on deposition of nanoparticles and attachment-detachment of nanoparticles on model membranes in complex fluid systems. We will first describe the working principle of QCM-D and DLVO theory pertinent to understanding nanoparticle deposition phenomena. The interactions between different nanoparticles and functionalized surfaces for different application areas are then critically reviewed. Finally, the potential applications of QCM-D in other important fields are proposed and knowledge gaps are identified. Copyright © 2015 Elsevier B.V. All rights reserved.

Mechanisms, Capabilities, and Applications of High-Resolution Electrohydrodynamic Jet Printing.

PubMed

Onses, M Serdar; Sutanto, Erick; Ferreira, Placid M; Alleyne, Andrew G; Rogers, John A

2015-09-09

This review gives an overview of techniques used for high-resolution jet printing that rely on electrohydrodynamically induced flows. Such methods enable the direct, additive patterning of materials with a resolution that can extend below 100 nm to provide unique opportunities not only in scientific studies but also in a range of applications that includes printed electronics, tissue engineering, and photonic and plasmonic devices. Following a brief historical perspective, this review presents descriptions of the underlying processes involved in the formation of liquid cones and jets to establish critical factors in the printing process. Different printing systems that share similar principles are then described, along with key advances that have been made in the last decade. Capabilities in terms of printable materials and levels of resolution are reviewed, with a strong emphasis on areas of potential application. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

The 5C Concept and 5S Principles in Inflammatory Bowel Disease Management.

PubMed

Hibi, Toshifumi; Panaccione, Remo; Katafuchi, Miiko; Yokoyama, Kaoru; Watanabe, Kenji; Matsui, Toshiyuki; Matsumoto, Takayuki; Travis, Simon; Suzuki, Yasuo

2017-10-27

The international Inflammatory Bowel Disease [IBD] Expert Alliance initiative [2012-2015] served as a platform to define and support areas of best practice in IBD management to help improve outcomes for all patients with IBD. During the programme, IBD specialists from around the world established by consensus two best practice charters: the 5S Principles and the 5C Concept. The 5S Principles were conceived to provide health care providers with key guidance for improving clinical practice based on best management approaches. They comprise the following categories: Stage the disease; Stratify patients; Set treatment goals; Select appropriate treatment; and Supervise therapy. Optimised management of patients with IBD based on the 5S Principles can be achieved most effectively within an optimised clinical care environment. Guidance on optimising the clinical care setting in IBD management is provided through the 5C Concept, which encompasses: Comprehensive IBD care; Collaboration; Communication; Clinical nurse specialists; and Care pathways. Together, the 5C Concept and 5S Principles provide structured recommendations on organising the clinical care setting and developing best-practice approaches in IBD management. Consideration and application of these two dimensions could help health care providers optimise their IBD centres and collaborate more effectively with their multidisciplinary team colleagues and patients, to provide improved IBD care in daily clinical practice. Ultimately, this could lead to improved outcomes for patients with IBD. Copyright © 2017 European Crohn’s and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com

Principles of Economics Textbooks: Innovation and Product Differentiation--A Response.

ERIC Educational Resources Information Center

Sichel, Werner

1988-01-01

Focusing on areas of contention, the author responds to "Principles of Economics Textbooks: Innovation and Product Differentiation" by Stiglitz. Contends that Stiglitz's description of principles textbooks is insufficient, states that the textbook market is more oligopolistic than monopolistic, and cautions writers against deleting parts…

76 FR 64083 - Loveland Area Projects-2025 Power Marketing Initiative Proposal

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-17

..., with amendments to key marketing plan principles. This Federal Register notice initiates Western's... published in the Federal Register (51 FR 4012, January 31, 1986) and provided the marketing plan principles... provided customers the opportunity to review current marketing plan principles and provide informal input...

Investigating surety methodologies for cognitive systems.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Caudell, Thomas P.; Peercy, David Eugene; Mills, Kristy

2006-11-01

Advances in cognitive science provide a foundation for new tools that promise to advance human capabilities with significant positive impacts. As with any new technology breakthrough, associated technical and non-technical risks are involved. Sandia has mitigated both technical and non-technical risks by applying advanced surety methodologies in such areas as nuclear weapons, nuclear reactor safety, nuclear materials transport, and energy systems. In order to apply surety to the development of cognitive systems, we must understand the concepts and principles that characterize the certainty of a system's operation as well as the risk areas of cognitive sciences. This SAND report documentsmore » a preliminary spectrum of risks involved with cognitive sciences, and identifies some surety methodologies that can be applied to potentially mitigate such risks. Some potential areas for further study are recommended. In particular, a recommendation is made to develop a cognitive systems epistemology framework for more detailed study of these risk areas and applications of surety methods and techniques.« less

Overview of NASA Glenn Seal Program

NASA Technical Reports Server (NTRS)

Steinetz, Bruce M.; Proctor, Margaret P.; Dunlap, Patrick H., Jr.; Delgado, Irebert; DeMange, Jeffrey J.; Daniels, Christopher C.; Lattime, Scott B.

2003-01-01

The Seal Team is divided into four primary areas. These areas include turbine engine seal development, structural seal development, acoustic seal development, and adaptive seal development. The turbine seal area focuses on high temperature, high speed shaft seals for secondary air system flow management. The structural seal area focuses on high temperature, resilient structural seals required to accommodate large structural distortions for both space- and aero-applications. Our goal in the acoustic seal project is to develop non-contacting, low leakage seals exploiting the principles of advanced acoustics. We are currently investigating a new acoustic field known as Resonant Macrosonic Synthesis (RMS) to see if we can harness the large acoustic standing pressure waves to form an effective air-barrier/seal. Our goal in the adaptive seal project is to develop advanced sealing approaches for minimizing blade-tip (shroud) or interstage seal leakage. We are planning on applying either rub-avoidance or regeneration clearance control concepts (including smart structures and materials) to promote higher turbine engine efficiency and longer service lives.

20 CFR 437.22 - Allowable costs.

Code of Federal Regulations, 2010 CFR

2010-04-01

... CFR Part 31. Contract Cost Principles and Procedures, or uniform cost accounting standards that comply... COOPERATIVE AGREEMENTS TO STATE AND LOCAL GOVERNMENTS Post-Award Requirements Financial Administration § 437...) Applicable cost principles. For each kind of organization, there is a set of Federal principles for...

14 CFR 1273.22 - Allowable costs.

Code of Federal Regulations, 2010 CFR

2010-01-01

... CFR part 31, Contract Cost Principles and Procedures, or uniform cost accounting standards that comply... GRANTS AND COOPERATIVE AGREEMENTS TO STATE AND LOCAL GOVERNMENTS Post-Award Requirements Financial.... (b) Applicable cost principles. For each kind of organization, there is a set of Federal principles...

15 CFR 24.22 - Allowable costs.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Part 31. Contract Cost Principles and Procedures, or uniform cost accounting standards that comply with... GRANTS AND COOPERATIVE AGREEMENTS TO STATE AND LOCAL GOVERNMENTS Post-Award Requirements Financial...) Applicable cost principles. For each kind of organization, there is a set of Federal principles for...

45 CFR 1174.22 - Allowable costs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Part 31. Contract Cost Principles and Procedures, or uniform cost accounting standards that comply with... COOPERATIVE AGREEMENTS TO STATE AND LOCAL GOVERNMENTS Post-Award Requirements Financial Administration § 1174...) Applicable cost principles. For each kind of organization, there is a set of Federal principles for...

45 CFR 1183.22 - Allowable costs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Part 31. Contract Cost Principles and Procedures, or uniform cost accounting standards that comply with... COOPERATIVE AGREEMENTS TO STATE AND LOCAL GOVERNMENTS Post-Award Requirements Financial Administration § 1183...) Applicable cost principles. For each kind of organization, there is a set of Federal principles for...

21 CFR 1403.22 - Allowable costs.

Code of Federal Regulations, 2010 CFR

2010-04-01

.... Contract Cost Principles and Procedures, or uniform cost accounting standards that comply with cost... COOPERATIVE AGREEMENTS TO STATE AND LOCAL GOVERNMENTS Post-Award Requirements Financial Administration § 1403...) Applicable cost principles. For each kind of organization, there is a set of Federal principles for...

On Ruch's Principle of Decreasing Mixing Distance in classical statistical physics

NASA Astrophysics Data System (ADS)

Busch, Paul; Quadt, Ralf

1990-10-01

Ruch's Principle of Decreasing Mixing Distance is reviewed as a statistical physical principle and its basic suport and geometric interpretation, the Ruch-Schranner-Seligman theorem, is generalized to be applicable to a large representative class of classical statistical systems.

Lean Principles and Defense Information Technology Acquisition: An Investigation of the Determinants of Successful Application

ERIC Educational Resources Information Center

Haley, M.

2013-01-01

The purpose of this study was to investigate whether or not there have been successful applications of lean manufacturing principles in highly variable defense IT environments. Specifically, the study assessed if implementation of the lean philosophies by a defense organization yielded repeatable, predictable results in software release schedules…

32 CFR 11.4 - Applicable principles of law.

Code of Federal Regulations, 2011 CFR

2011-07-01

... an Accused under the law of armed conflict, such as self-defense, mistake of fact, and duress, may be... 32 National Defense 1 2011-07-01 2011-07-01 false Applicable principles of law. 11.4 Section 11.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS CRIMES AND...

32 CFR 11.4 - Applicable principles of law.

Code of Federal Regulations, 2012 CFR

2012-07-01

... an Accused under the law of armed conflict, such as self-defense, mistake of fact, and duress, may be... 32 National Defense 1 2012-07-01 2012-07-01 false Applicable principles of law. 11.4 Section 11.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS CRIMES AND...

32 CFR 11.4 - Applicable principles of law.

Code of Federal Regulations, 2013 CFR

2013-07-01

... an Accused under the law of armed conflict, such as self-defense, mistake of fact, and duress, may be... 32 National Defense 1 2013-07-01 2013-07-01 false Applicable principles of law. 11.4 Section 11.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS CRIMES AND...

32 CFR 11.4 - Applicable principles of law.

Code of Federal Regulations, 2014 CFR

2014-07-01

... an Accused under the law of armed conflict, such as self-defense, mistake of fact, and duress, may be... 32 National Defense 1 2014-07-01 2014-07-01 false Applicable principles of law. 11.4 Section 11.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS CRIMES AND...

40 CFR Appendix E to Part 52 - Performance Specifications and, Specification Test Procedures for Monitoring Systems for Effluent...

Code of Federal Regulations, 2011 CFR

2011-07-01

..., Specification Test Procedures for Monitoring Systems for Effluent Stream Gas Volumetric Flow Rate E Appendix E... Stream Gas Volumetric Flow Rate 1. Principle and applicability. 1.1Principle. Effluent stream gas... method is applicable to subparts which require continuous gas volumetric flow rate measurement...

40 CFR Appendix E to Part 52 - Performance Specifications and, Specification Test Procedures for Monitoring Systems for Effluent...

Code of Federal Regulations, 2010 CFR

2010-07-01

..., Specification Test Procedures for Monitoring Systems for Effluent Stream Gas Volumetric Flow Rate E Appendix E... Stream Gas Volumetric Flow Rate 1. Principle and applicability. 1.1Principle. Effluent stream gas... method is applicable to subparts which require continuous gas volumetric flow rate measurement...

Application of the Total Quality Management Approach Principles and the ISO 9000 Standards in Engineering Education.

ERIC Educational Resources Information Center

Waks, Shlomo; Frank, Moti

1999-01-01

Discusses the applicability of the definition, principles, and underlying strategies of total quality management (TQM) for engineering education. Describes several tools and methods for the implementation of TQM and its suitability for a variety of school activities. Presents a TQM course outline combining lectures, discussions, suggested…

76 FR 61597 - Grants and Cooperative Agreements to State and Local Governments: DOT Amendments on Regulations...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-05

... to applicable cost principles for grants and cooperative agreements with State and Local Governments... grant funds while 49 CFR 19.27 merely lists cost principles applicable to each kind of grant and... comment was received, from Robert Taylor, regarding the Office of Management and Budget (OMB) cost...

Uniqueness of Zinc as a Bioelement: Principles and Applications in Bioinorganic Chemistry--III.

ERIC Educational Resources Information Center

Ochiai, Ei-Ichiro

1988-01-01

Attempts to delineate certain basic principles and applications of bioinorganic chemistry to oxidation-reduction reactions. Examines why zinc(II) is so uniquely suited to enzymated reactions of the acid-base type. Suggests the answer may be in the natural abundance and the basic physicochemical properties of zinc(II). (MVL)

Striving for Excellence: Applications of Successful Business Principles. Ideas for Action in Education and Work.

ERIC Educational Resources Information Center

Owens, Tom

Eight principles that have been used to reach excellence in business and industry and ways that schools can apply those principles are described. The principles, identified by Thomas J. Peters and Robert N. Waterman, Jr. in "In Search of Excellence: Lessons from America's Best-Run Companies" are: (1) a bias for action (not waiting for…

Twelve tips for utilizing principles of learning to support medical education.

PubMed

Cutting, Maris F; Saks, Norma Susswein

2012-01-01

Research in the cognitive sciences on learning and memory conducted across a range of domains, settings, and age groups has resulted in the identification and formulation of a set of generic learning principles. These learning principles have proven relevant and applicable to a wide range of learning situations in a variety of settings, and can be useful in supporting medical education. They can provide guidance to medical students for efficient and effective study, and can be helpful to faculty to support instructional planning and decisions relating to curriculum. This article discusses evidence-based principles of learning and their relationship to effective learning, teaching, pedagogy and curriculum development. We reviewed important principles of learning to determine those most relevant to improving medical student learning, guiding faculty toward more effective teaching, and in designing a curriculum. Our analysis has resulted in the articulation of key learning principles and specific strategies that are broadly applicable to medical school learning, teaching, and instructional planning. The twelve tips highlight principles of learning that can be effectively applied in the complex learning environment of medical education.

Creating a fair and just culture: one institution's pat toward organizational change.

PubMed

Connor, Maureen; Duncombe, Deborah; Barclay, Emily; Bartel, Sylvia; Borden, Charles; Gross, Elizabeth; Miller, Carol; Ponte, Patricia Reid

2007-10-01

Health care organizations have begun to move toward a nonpunitive, or "blame-free," process when analyzing medical errors and near misses. The Dana-Farber Cancer Institute's (Boston) "Principles of a Fair and Just Culture," define for staff and managers behavioral expectations when an error occurs. The principles focus not just on patient safety but on a culture of safety and transparency in all the organization's functional areas, including nonclinical departments such as information services, administration, and research. Introducing the principles is a gradual process, one that requires continual education and discussion among staff at all levels and a commitment to examining and changing many of the systems, policies, and procedures that guide the organization's work. A survey conducted in January 2007 revealed that the clinical areas had sustained higher-than-average scores and that the nonclinical areas showed improvement. Changing a long-standing culture of blame, control, and disrespect to one that embraces principles of fairness and justice and standards of respectful behavior is a major undertaking. Educating and involving clinical and administrative leaders, who work directly with staff and play a pivotal role in translating the principles into practice, is especially important.

Connection of Scattering Principles: A Visual and Mathematical Tour

ERIC Educational Resources Information Center

Broggini, Filippo; Snieder, Roel

2012-01-01

Inverse scattering, Green's function reconstruction, focusing, imaging and the optical theorem are subjects usually studied as separate problems in different research areas. We show a physical connection between the principles because the equations that rule these "scattering principles" have a similar functional form. We first lead the reader…

Microfluidic large-scale integration: the evolution of design rules for biological automation.

PubMed

Melin, Jessica; Quake, Stephen R

2007-01-01

Microfluidic large-scale integration (mLSI) refers to the development of microfluidic chips with thousands of integrated micromechanical valves and control components. This technology is utilized in many areas of biology and chemistry and is a candidate to replace today's conventional automation paradigm, which consists of fluid-handling robots. We review the basic development of mLSI and then discuss design principles of mLSI to assess the capabilities and limitations of the current state of the art and to facilitate the application of mLSI to areas of biology. Many design and practical issues, including economies of scale, parallelization strategies, multiplexing, and multistep biochemical processing, are discussed. Several microfluidic components used as building blocks to create effective, complex, and highly integrated microfluidic networks are also highlighted.

Aerodynamic characteristics of airplanes at high angles of attack

NASA Technical Reports Server (NTRS)

Chambers, J. R.; Grafton, S. B.

1977-01-01

An introduction to, and a broad overiew of, the aerodynamic characteristics of airplanes at high angles of attack are provided. Items include: (1) some important fundamental phenomena which determine the aerodynamic characteristics of airplanes at high angles of attack; (2) static and dynamic aerodynamic characteristics near the stall; (3) aerodynamics of the spin; (4) test techniques used in stall/spin studies; (5) applications of aerodynamic data to problems in flight dynamics in the stall/spin area; and (6) the outlook for future research in the area. Although stalling and spinning are flight dynamic problems of importance to all aircraft, including general aviation aircraft, commercial transports, and military airplanes, emphasis is placed on military configurations and the principle aerodynamic factors which influence the stability and control of such vehicles at high angles of attack.

[Application of near infrared spectroscopy technology (NIRS) in forage field].

PubMed

Yan, Xu; Bai, Shi-Qie; Yan, Jia-Jun; Gan, You-Min; Dao, Zhi-Xue

2012-07-01

The majority of nutrients in ruminants and other herbivores come from forages. Forage quality not only affects the growth and production efficiency of livestock, but also determines the final output and quality of livestock products. Forage quality mainly depends on nutrient concentrations and their digestibility, palatability and the level of presence of antiquality factors and mycotoxins in forage. Near infrared reflectance spectroscopy (NIRS) has been widely used in many research areas because it is a inexpensive, rapid, simple and nondestructive technique offering the potential for qualitative and quantitative analysis. The present paper briefly introduces the principle and characteristics of NIRS, detailedly expounds the application of NIRS in forage quality. In addition, other applications of near infrared spectroscopy technique in forage are also discussed, including forage breeding, identification of variety and classification by kind. This paper comprehensively reviews the status quo of application of NIRS in forage filed, in order to contribute to promoting development of NIRS in this field in China.

Nonlinear dynamical systems for theory and research in ergonomics.

PubMed

Guastello, Stephen J

2017-02-01

Nonlinear dynamical systems (NDS) theory offers new constructs, methods and explanations for phenomena that have in turn produced new paradigms of thinking within several disciplines of the behavioural sciences. This article explores the recent developments of NDS as a paradigm in ergonomics. The exposition includes its basic axioms, the primary constructs from elementary dynamics and so-called complexity theory, an overview of its methods, and growing areas of application within ergonomics. The applications considered here include: psychophysics, iconic displays, control theory, cognitive workload and fatigue, occupational accidents, resilience of systems, team coordination and synchronisation in systems. Although these applications make use of different subsets of NDS constructs, several of them share the general principles of the complex adaptive system. Practitioner Summary: Nonlinear dynamical systems theory reframes problems in ergonomics that involve complex systems as they change over time. The leading applications to date include psychophysics, control theory, cognitive workload and fatigue, biomechanics, occupational accidents, resilience of systems, team coordination and synchronisation of system components.

Principles and applications of Raman spectroscopy in pharmaceutical drug discovery and development.

PubMed

Gala, Urvi; Chauhan, Harsh

2015-02-01

In recent years, Raman spectroscopy has become increasingly important as an analytical technique in various scientific areas of research and development. This is partly due to the technological advancements in Raman instrumentation and partly due to detailed fingerprinting that can be derived from Raman spectra. Its versatility of applications, rapidness of collection and easy analysis have made Raman spectroscopy an attractive analytical tool. The following review describes Raman spectroscopy and its application within the pharmaceutical industry. The authors explain the theory of Raman scattering and its variations in Raman spectroscopy. The authors also highlight how Raman spectra are interpreted, providing examples. Raman spectroscopy has a number of potential applications within drug discovery and development. It can be used to estimate the molecular activity of drugs and to establish a drug's physicochemical properties such as its partition coefficient. It can also be used in compatibility studies during the drug formulation process. Raman spectroscopy's immense potential should be further investigated in future.

Review of the Usefulness of Various Rotational Seismometers with Laboratory Results of Fibre-Optic Ones Tested for Engineering Applications

PubMed Central

Jaroszewicz, Leszek R.; Kurzych, Anna; Krajewski, Zbigniew; Marć, Paweł; Kowalski, Jerzy K.; Bobra, Piotr; Zembaty, Zbigniew; Sakowicz, Bartosz; Jankowski, Robert

2016-01-01

Starting with descriptions of rotational seismology, areas of interest and historical field measurements, the fundamental requirements for rotational seismometers for seismological and engineering application are formulated. On the above basis, a review of all existing rotational seismometers is presented with a description of the principles of their operation as well as possibilities to fulfill formulated requirements. This review includes mechanical, acoustical, electrochemical and optical devices and shows that the last of these types are the most promising. It is shown that optical rotational seismometer based on the ring-laser gyroscope concept is the best for seismological applications, whereas systems based on fiber-optic gyroscopes demonstrate parameters which are also required for engineering applications. Laboratory results of the Fibre-Optic System for Rotational Events & Phenomena Monitoring using a small 1-D shaking table modified to generate rotational excitations are presented. The harmonic and time-history tests demonstrate its usefulness for recording rotational motions with rates up to 0.25 rad/s. PMID:27999299

Principled Leadership and Business Diplomacy. A Practical, Values-Based Direction for Management Development.

ERIC Educational Resources Information Center

London, Manuel

1999-01-01

Describes business diplomacy based on the Japanese concept of kyosei (working for the common good). Gives case examples of application of principled diplomacy to ethical dilemmas and suggests ways to establish an organizational culture to support principled business leadership. (SK)

Deep into the Brain: Artificial Intelligence in Stroke Imaging

PubMed Central

Lee, Eun-Jae; Kim, Yong-Hwan; Kim, Namkug; Kang, Dong-Wha

2017-01-01

Artificial intelligence (AI), a computer system aiming to mimic human intelligence, is gaining increasing interest and is being incorporated into many fields, including medicine. Stroke medicine is one such area of application of AI, for improving the accuracy of diagnosis and the quality of patient care. For stroke management, adequate analysis of stroke imaging is crucial. Recently, AI techniques have been applied to decipher the data from stroke imaging and have demonstrated some promising results. In the very near future, such AI techniques may play a pivotal role in determining the therapeutic methods and predicting the prognosis for stroke patients in an individualized manner. In this review, we offer a glimpse at the use of AI in stroke imaging, specifically focusing on its technical principles, clinical application, and future perspectives. PMID:29037014

Indocyanine green-incorporating nanoparticles for cancer theranostics

PubMed Central

Wang, Haolu; Li, Xinxing; Tse, Brian Wan-Chi; Yang, Haotian; Thorling, Camilla A.; Liu, Yuxin; Touraud, Margaux; Chouane, Jean Batiste; Liu, Xin; Roberts, Michael S.; Liang, Xiaowen

2018-01-01

Indocyanine green (ICG) is a near-infrared dye that has been used in the clinic for retinal angiography, and defining cardiovascular and liver function for over 50 years. Recently, there has been an increasing interest in the incorporation of ICG into nanoparticles (NPs) for cancer theranostic applications. Various types of ICG-incorporated NPs have been developed and strategically functionalised to embrace multiple imaging and therapeutic techniques for cancer diagnosis and treatment. This review systematically summaries the biodistribution of various types of ICG-incorporated NPs for the first time, and discusses the principles, opportunities, limitations, and application of ICG-incorporated NPs for cancer theranostics. We believe that ICG-incorporated NPs would be a promising multifunctional theranostic platform in oncology and facilitate significant advancements in this research-active area. PMID:29507616

Internal Model-Based Robust Tracking Control Design for the MEMS Electromagnetic Micromirror.

PubMed

Tan, Jiazheng; Sun, Weijie; Yeow, John T W

2017-05-26

The micromirror based on micro-electro-mechanical systems (MEMS) technology is widely employed in different areas, such as scanning, imaging and optical switching. This paper studies the MEMS electromagnetic micromirror for scanning or imaging application. In these application scenarios, the micromirror is required to track the command sinusoidal signal, which can be converted to an output regulation problem theoretically. In this paper, based on the internal model principle, the output regulation problem is solved by designing a robust controller that is able to force the micromirror to track the command signal accurately. The proposed controller relies little on the accuracy of the model. Further, the proposed controller is implemented, and its effectiveness is examined by experiments. The experimental results demonstrate that the performance of the proposed controller is satisfying.

Internal Model-Based Robust Tracking Control Design for the MEMS Electromagnetic Micromirror

PubMed Central

Tan, Jiazheng; Sun, Weijie; Yeow, John T. W.

2017-01-01

The micromirror based on micro-electro-mechanical systems (MEMS) technology is widely employed in different areas, such as scanning, imaging and optical switching. This paper studies the MEMS electromagnetic micromirror for scanning or imaging application. In these application scenarios, the micromirror is required to track the command sinusoidal signal, which can be converted to an output regulation problem theoretically. In this paper, based on the internal model principle, the output regulation problem is solved by designing a robust controller that is able to force the micromirror to track the command signal accurately. The proposed controller relies little on the accuracy of the model. Further, the proposed controller is implemented, and its effectiveness is examined by experiments. The experimental results demonstrate that the performance of the proposed controller is satisfying. PMID:28587105

Clinical application of plasma thermograms. Utility, practical approaches and considerations.

PubMed

Garbett, Nichola C; Mekmaysy, Chongkham S; DeLeeuw, Lynn; Chaires, Jonathan B

2015-04-01

Differential scanning calorimetry (DSC) studies of blood plasma are part of an emerging area of the clinical application of DSC to biofluid analysis. DSC analysis of plasma from healthy individuals and patients with various diseases has revealed changes in the thermal profiles of the major plasma proteins associated with the clinical status of the patient. The sensitivity of DSC to the concentration of proteins, their interactions with other proteins or ligands, or their covalent modification underlies the potential utility of DSC analysis. A growing body of literature has demonstrated the versatility and performance of clinical DSC analysis across a range of biofluids and in a number of disease settings. The principles, practice and challenges of DSC analysis of plasma are described in this article. Copyright © 2014 Elsevier Inc. All rights reserved.

Vapor-Phase Deposition and Modification of Metal-Organic Frameworks: State-of-the-Art and Future Directions.

PubMed

Stassen, Ivo; De Vos, Dirk; Ameloot, Rob

2016-10-04

Materials processing, and thin-film deposition in particular, is decisive in the implementation of functional materials in industry and real-world applications. Vapor processing of materials plays a central role in manufacturing, especially in electronics. Metal-organic frameworks (MOFs) are a class of nanoporous crystalline materials on the brink of breakthrough in many application areas. Vapor deposition of MOF thin films will facilitate their implementation in micro- and nanofabrication research and industries. In addition, vapor-solid modification can be used for postsynthetic tailoring of MOF properties. In this context, we review the recent progress in vapor processing of MOFs, summarize the underpinning chemistry and principles, and highlight promising directions for future research. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

An introduction to the global positioning system and some geological applications

NASA Technical Reports Server (NTRS)

Dixon, T. H.

1991-01-01

The fundamental principles of the global positioning system (GPS) are reviewed, with consideration given to geological and geophysical applications and related accuracy requirements. Recent improvements are emphasized which relate to areas such as equipment cost, limitations in the GPS satellite constellation, data analysis, uncertainties in satellite orbits and propagation delays, and problems in resolving carrier phase cycle ambiguities. Earthquake processes and near-fault crustal deformation monitoring have been facilitated by advances in GPS data acquisition and analysis. Horizontal positioning capability has been improved by new satellite constellation, better models, and global tracking networks. New classes of tectonic problems may now be studied through GPS, such as kinematic descriptions of crustal deformation and the measurement of relative plate motion at convergent boundaries. Continued improvements in the GPS are foreseen.

Deep into the Brain: Artificial Intelligence in Stroke Imaging.

PubMed

Lee, Eun-Jae; Kim, Yong-Hwan; Kim, Namkug; Kang, Dong-Wha

2017-09-01

Artificial intelligence (AI), a computer system aiming to mimic human intelligence, is gaining increasing interest and is being incorporated into many fields, including medicine. Stroke medicine is one such area of application of AI, for improving the accuracy of diagnosis and the quality of patient care. For stroke management, adequate analysis of stroke imaging is crucial. Recently, AI techniques have been applied to decipher the data from stroke imaging and have demonstrated some promising results. In the very near future, such AI techniques may play a pivotal role in determining the therapeutic methods and predicting the prognosis for stroke patients in an individualized manner. In this review, we offer a glimpse at the use of AI in stroke imaging, specifically focusing on its technical principles, clinical application, and future perspectives.

Clinical application of plasma thermograms. Utility, practical approaches and considerations

PubMed Central

Garbett, Nichola C.; Mekmaysy, Chongkham S.; DeLeeuw, Lynn; Chaires, Jonathan B.

2014-01-01

Differential scanning calorimetry (DSC) studies of blood plasma are part of an emerging area of the clinical application of DSC to biofluid analysis. DSC analysis of plasma from healthy individuals and patients with various diseases has revealed changes in the thermal profiles of the major plasma proteins associated with the clinical status of the patient. The sensitivity of DSC to the concentration of proteins, their interactions with other proteins or ligands, or their covalent modifications underlies the potential utility of DSC analysis. A growing body of literature has demonstrated the versatility and performance of clinical DSC analysis across a range of biofluids and in a number of disease settings. The principles, practice and challenges of DSC analysis of plasma are described in this article. PMID:25448297

Electric propulsion - Characteristics, applications, and status

NASA Technical Reports Server (NTRS)

Maloy, J. E.; Dulgeroff, C. R.; Poeschel, R. L.

1981-01-01

As chemical propulsion systems were achieving their ultimate capability for planetary exploration, space scientists were developing solar electric propulsion as the propulsion system need for future missions. This paper provides a comparative review of the principles of ion thruster and chemical rocket operations and discusses the current status of the 30-cm mercury ion thruster development and the specifications imposed on the 30-cm thruster by the Solar Electric Propulsion System program. The 30-cm thruster operating range, efficiency, wear out lifetime, and interface requirements are described. Finally, the areas of 30-cm thruster technology that remain to be refined are discussed.

State-of-the art of selective detection and identification of I-, Br-, Cl-, and F-containing compounds in gas chromatography and liquid chromatography.

PubMed

Brede, Cato; Pedersen-Bjergaard, Stig

2004-09-24

This review article presents an overview of halogen-specific detection in gas chromatography (GC) and liquid chromatography (LC). Attention is primarily focused on the use of plasma emission spectroscopy and plasma mass spectrometry as detectors, but other halogen-selective detection principles are also mentioned. Different instrumental configurations are discussed both with respect to technical set-up and performance, the principal reasons for halogen-selective detection are highlighted, and recent applications are reviewed from areas such as environmental chemistry, petroleum characterization, and drug analysis.

Space Station logistics policy - Risk management from the top down

NASA Technical Reports Server (NTRS)

Paules, Granville; Graham, James L., Jr.

1990-01-01

Considerations are presented in the area of risk management specifically relating to logistics and system supportability. These considerations form a basis for confident application of concurrent engineering principles to a development program, aiming at simultaneous consideration of support and logistics requirements within the engineering process as the system concept and designs develop. It is shown that, by applying such a process, the chances of minimizing program logistics and supportability risk in the long term can be improved. The problem of analyzing and minimizing integrated logistics risk for the Space Station Freedom Program is discussed.

Optical sensors in water monitoring

NASA Astrophysics Data System (ADS)

Gauglitz, Guenter

2007-07-01

An upcoming problem in Europe is the protection of water resources and control of water quality. Coastal areas, rivers, ground water, wetlands, and especially drinking water require permanent monitoring to avoid pollution by small organic molecules or especially endocrine disrupting compounds. Biosensors have demonstrated the proof-of-principle of immunochemistry for these applications. It turns out that especially optical methods based on fluorescence detection can be successfully used for the development of fast, sensitive, cost-effective, and easy-to-use analytical systems meeting the requirements given by European Community Directives and national legislation. Results obtained with the RIANA and AWACSS systems are discussed here.

19 CFR 10.470 - Verification and justification of claim for preferential treatment.

Code of Federal Regulations, 2010 CFR

2010-04-01

... accounting and financial records, information relating to the place of production, the number and...) Applicable accounting principles. When conducting a verification of origin to which Generally Accepted Accounting Principles may be relevant, CBP will apply and accept the Generally Accepted Accounting Principles...

APPLYING ECOLOGICAL PRINCIPLES TO LAND-USE DECISION MAKING IN AGRICULTURAL WATERSHEDS

EPA Science Inventory

The Ecological Society of America on sustainable Land Use has put together a set of ecological principles and guidelines to help in land-use decision making. The practical application of these principles and the associated guidelines to planning efforts in real landscapes will r...

A Lemon Cell Battery for High-Power Applications

ERIC Educational Resources Information Center

Muske, Kenneth R.; Nigh, Christopher W.; Weinstein, Randy D.

2007-01-01

The use of lemon cell battery to run an electric DC motor is demonstrated for chemistry students. This demonstration aids the students in understanding principles behind the design and construction of the lemon cell battery and principles governing the electric DC motor and other basic principles.

Principles of Electronegativity Part 1. General Nature.

ERIC Educational Resources Information Center

Sanderson, R. T.

1988-01-01

Summarizes the general principles governing the significance and applications of electronegativity. Presents and discusses seven principles in a general way. Describes electronegativity in general as a consequence of incompletely screened nuclear charge effective within stable outer orbital vacancies, which in turn is a function of the atomic…

Coupled structural, thermal, phase-change and electromagnetic analysis for superconductors, volume 2

NASA Technical Reports Server (NTRS)

Felippa, Carlos A.; Farhat, Charbel; Park, K. C.; Militello, Carmelo; Schuler, James J.

1993-01-01

Two families of parametrized mixed variational principles for linear electromagnetodynamics are constructed. The first family is applicable when the current density distribution is known a priori. Its six independent fields are magnetic intensity and flux density, magnetic potential, electric intensity and flux density and electric potential. Through appropriate specialization of parameters the first principle reduces to more conventional principles proposed in the literature. The second family is appropriate when the current density distribution and a conjugate Lagrange multiplier field are adjoined, giving a total of eight independently varied fields. In this case it is shown that a conventional variational principle exists only in the time-independent (static) case. Several static functionals with reduced number of varied fields are presented. The application of one of these principles to construct finite elements with current prediction capabilities is illustrated with a numerical example.

The maximum entropy production principle: two basic questions.

PubMed

Martyushev, Leonid M

2010-05-12

The overwhelming majority of maximum entropy production applications to ecological and environmental systems are based on thermodynamics and statistical physics. Here, we discuss briefly maximum entropy production principle and raises two questions: (i) can this principle be used as the basis for non-equilibrium thermodynamics and statistical mechanics and (ii) is it possible to 'prove' the principle? We adduce one more proof which is most concise today.

A Canadian framework for applying the precautionary principle to public health issues.

PubMed

Weir, Erica; Schabas, Richard; Wilson, Kumanan; Mackie, Chris

2010-01-01

The precautionary principle has influenced environmental and public health policy. It essentially states that complete evidence of a potential risk is not required before action is taken to mitigate the effects of the potential risk. The application of precaution to public health issues is not straightforward and could paradoxically cause harm to the public's health when applied inappropriately. To avoid this, we propose a framework for applying the precautionary principle to potential public health risks. The framework consists of ten guiding questions to help establish whether a proposed application of the precautionary principle on a public health matter is based on adequacy of the evidence of causation, severity of harm and acceptability of the precautionary measures.

TU-F-BRD-01: Biomedical Informatics for Medical Physicists

DOE Office of Scientific and Technical Information (OSTI.GOV)

Phillips, M; Kalet, I; McNutt, T

Biomedical informatics encompasses a very large domain of knowledge and applications. This broad and loosely defined field can make it difficult to navigate. Physicists often are called upon to provide informatics services and/or to take part in projects involving principles of the field. The purpose of the presentations in this symposium is to help medical physicists gain some knowledge about the breadth of the field and how, in the current clinical and research environment, they can participate and contribute. Three talks have been designed to give an overview from the perspective of physicists and to provide a more in-depth discussionmore » in two areas. One of the primary purposes, and the main subject of the first talk, is to help physicists achieve a perspective about the range of the topics and concepts that fall under the heading of 'informatics'. The approach is to de-mystify topics and jargon and to help physicists find resources in the field should they need them. The other talks explore two areas of biomedical informatics in more depth. The goal is to highlight two domains of intense current interest--databases and models--in enough depth into current approaches so that an adequate background for independent inquiry is achieved. These two areas will serve as good examples of how physicists, using informatics principles, can contribute to oncology practice and research. Learning Objectives: To understand how the principles of biomedical informatics are used by medical physicists. To put the relevant informatics concepts in perspective with regard to biomedicine in general. To use clinical database design as an example of biomedical informatics. To provide a solid background into the problems and issues of the design and use of data and databases in radiation oncology. To use modeling in the service of decision support systems as an example of modeling methods and data use. To provide a background into how uncertainty in our data and knowledge can be incorporated into modeling methods.« less

Unified Technical Concepts--Phase II. Expand Application to Industrial Technologies and Adult Education. Final Report.

ERIC Educational Resources Information Center

Technical Education Research Center, Waco, TX.

A project was conducted to develop a laboratory-based instructional system in physics for two-year technician programs that emphasizes both the analogies between basic physical principles and the applications of the principles in modern technology. The Unified Technical Concepts (UTC) system that was developed is (1) a reorganization of physics…

Creating Learning Organizations: The Deming Management Method Applied to Instruction (Quality Teaching & Quality Learning). A Paradigm Application.

ERIC Educational Resources Information Center

Loehr, Peter

This paper presents W. Edwards Deming's 14 management points, 7 deadly diseases, and 4 obstacles that thwart productivity, and discusses how these principles relate to teaching and learning. Application of these principles is expected to increase the quality of learning in classrooms from kindergarten through graduate level. Examples of the…

The Application of Service-Learning Principles to Support Our National Parks

ERIC Educational Resources Information Center

Coates, Tom

2005-01-01

Camping and working and learning in national parks may sound like a great way to spend the summer, but for participants enrolled in Rocky Mountain Experience, it is much more. Rocky Mountain Experience is a unique university course that focuses on application of service-learning principles as students travel to, camp in, and complete service…

Fundamental Principles of Coherent-Feedback Quantum Control

DTIC Science & Technology

2014-12-08

in metrology (acceleration sensing, vibrometry, gravity wave detection) and in quantum information processing (continuous-variables quantum ...AFRL-OSR-VA-TR-2015-0009 FUNDAMENTAL PRINCIPLES OF COHERENT-FEEDBACK QUANTUM CONTROL Hideo Mabuchi LELAND STANFORD JUNIOR UNIV CA Final Report 12/08...foundations and potential applications of coherent-feedback quantum control. We have focused on potential applications in quantum -enhanced metrology and

45 CFR Appendix E to Part 74 - Principles for Determining Costs Applicable to Research and Development Under Grants and...

Code of Federal Regulations, 2013 CFR

2013-10-01

... Research and Development Under Grants and Contracts With Hospitals E Appendix E to Part 74 Public Welfare... Research and Development Under Grants and Contracts With Hospitals i. purpose and scope A. Objectives. This appendix provides principles for determining the costs applicable to research and development work...

45 CFR Appendix E to Part 74 - Principles for Determining Costs Applicable to Research and Development Under Grants and...

Code of Federal Regulations, 2011 CFR

2011-10-01

... Research and Development Under Grants and Contracts With Hospitals E Appendix E to Part 74 Public Welfare... Research and Development Under Grants and Contracts With Hospitals i. purpose and scope A. Objectives. This appendix provides principles for determining the costs applicable to research and development work...

45 CFR Appendix E to Part 74 - Principles for Determining Costs Applicable to Research and Development Under Grants and...

Code of Federal Regulations, 2010 CFR

2010-10-01

... Research and Development Under Grants and Contracts With Hospitals E Appendix E to Part 74 Public Welfare... Research and Development Under Grants and Contracts With Hospitals i. purpose and scope A. Objectives. This appendix provides principles for determining the costs applicable to research and development work...

45 CFR Appendix E to Part 74 - Principles for Determining Costs Applicable to Research and Development Under Grants and...

Code of Federal Regulations, 2014 CFR

2014-10-01

... Research and Development Under Grants and Contracts With Hospitals E Appendix E to Part 74 Public Welfare... Research and Development Under Grants and Contracts With Hospitals i. purpose and scope A. Objectives. This appendix provides principles for determining the costs applicable to research and development work...

45 CFR Appendix E to Part 74 - Principles for Determining Costs Applicable to Research and Development Under Grants and...

Code of Federal Regulations, 2012 CFR

2012-10-01

... Research and Development Under Grants and Contracts With Hospitals E Appendix E to Part 74 Public Welfare... Research and Development Under Grants and Contracts With Hospitals i. purpose and scope A. Objectives. This appendix provides principles for determining the costs applicable to research and development work...

Can Evolutionary Principles Explain Patterns of Family Violence?

ERIC Educational Resources Information Center

Archer, John

2013-01-01

The article's aim is to evaluate the application of the evolutionary principles of kin selection, reproductive value, and resource holding power to the understanding of family violence. The principles are described in relation to specific predictions and the mechanisms underlying these. Predictions are evaluated for physical violence perpetrated…

32 CFR 32.27 - Allowable costs.

Code of Federal Regulations, 2010 CFR

2010-07-01

... contractor receiving a. cost-type contract under an assistance award, there is a set of Federal principles... principles applicable to the entity incurring the costs. (b) Governmental organizations. Allowability of... of OMB Circular A-87, 8 “Cost Principles for State and Local Governments.” 8 See footnote 1 to § 32.1...

10 CFR 600.317 - Allowable costs.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Allowable costs. (a) DOE determines allowability of costs in accordance with the cost principles applicable... OMB Circular A-122 is determined in accordance with the for-profit costs principles in 48 CFR part 31... accordance with OMB Circular A-21, “Cost Principles for Educational Institutions.” (ii) Other nonprofit...

41 CFR 101-27.102 - Economic order quantity principle.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Economic order quantity... MANAGEMENT 27.1-Stock Replenishment § 101-27.102 Economic order quantity principle. The economic order quantity (EOQ) principle is a means for achieving economical inventory management. Application of the EOQ...

Applying Brain-Based Learning Principles to Athletic Training Education

ERIC Educational Resources Information Center

Craig, Debbie I.

2007-01-01

Objective: To present different concepts and techniques related to the application of brain-based learning principles to Athletic Training clinical education. Background: The body of knowledge concerning how our brains physically learn continues to grow. Brain-based learning principles, developed by numerous authors, offer advice on how to…

41 CFR 101-27.102 - Economic order quantity principle.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 41 Public Contracts and Property Management 2 2011-07-01 2007-07-01 true Economic order quantity... MANAGEMENT 27.1-Stock Replenishment § 101-27.102 Economic order quantity principle. The economic order quantity (EOQ) principle is a means for achieving economical inventory management. Application of the EOQ...

41 CFR 101-27.102 - Economic order quantity principle.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 41 Public Contracts and Property Management 2 2012-07-01 2012-07-01 false Economic order quantity... MANAGEMENT 27.1-Stock Replenishment § 101-27.102 Economic order quantity principle. The economic order quantity (EOQ) principle is a means for achieving economical inventory management. Application of the EOQ...

41 CFR 101-27.102 - Economic order quantity principle.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 41 Public Contracts and Property Management 2 2013-07-01 2012-07-01 true Economic order quantity... MANAGEMENT 27.1-Stock Replenishment § 101-27.102 Economic order quantity principle. The economic order quantity (EOQ) principle is a means for achieving economical inventory management. Application of the EOQ...

41 CFR 101-27.102 - Economic order quantity principle.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 41 Public Contracts and Property Management 2 2014-07-01 2012-07-01 true Economic order quantity... MANAGEMENT 27.1-Stock Replenishment § 101-27.102 Economic order quantity principle. The economic order quantity (EOQ) principle is a means for achieving economical inventory management. Application of the EOQ...

Hooke's Law: Applications of a Recurring Principle

ERIC Educational Resources Information Center

Giuliodori, Mauricio J.; Lujan, Heidi L.; Briggs, Whitney S.; Palani, Gurunanthan; DiCarlo, Stephen E.

2009-01-01

Students generally approach topics in physiology as a series of unrelated phenomena that share few underlying principles. However, if students recognized that the same underlying principles can be used to explain many physiological phenomena, they may gain a more unified understanding of physiological systems. To address this concern, we…

76 FR 33409 - Guidance on Deposit-Related Consumer Credit Products

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-08

... OCC's application of principles of safe and sound banking practices in connection with deposit-related... guidance details the principles that the OCC expects national banks to follow in connection with any... without dictating specific product terms. The OCC expects national banks to apply the principles set forth...

A team public health research project for first-year pharmacy students to apply content from didactic courses.

PubMed

Fuentes, David; Deguire, Nancy; Patel, Rajul; Boyce, Eric

2010-08-10

To implement and assess a first-year pharmacy student group research project that provided practical hands-on application and reinforced the curricula of concurrent didactic courses. Groups of 6 to 7 students chose a public health topic based on the Healthy People 2010 Priority Areas and created a survey instrument. Faculty facilitated mock institutional review board (IRB) review sessions which provided teams with ongoing feedback and refinement recommendations before each team administered their survey instrument to a predefined population. Data analysis, formal written reports, and oral presentations were presented to peers and project faculty members. Teams complied with the requirements of the mock IRB, effectively applied basic research principles learned in class, collected survey data, performed inferential statistical analyses on the data, , and presented their project findings. Two-hundred six of 210 students (98%) reported feeling satisfied with both the results of their project and the accomplishments of their team. Teams applied a varied skill set including primary literature evaluation, basic research principles, statistics, public speaking, and peer collaboration in conducting a public health research project. First-year pharmacy students may benefit from participation in a collaborative research project that provides hands-on application of material being taught in didactic courses.

At the cross-roads of participatory research and biomarker discovery in autism: the need for empirical data.

PubMed

Yusuf, Afiqah; Elsabbagh, Mayada

2015-12-15

Identifying biomarkers for autism can improve outcomes for those affected by autism. Engaging the diverse stakeholders in the research process using community-based participatory research (CBPR) can accelerate biomarker discovery into clinical applications. However, there are limited examples of stakeholder involvement in autism research, possibly due to conceptual and practical concerns. We evaluate the applicability of CBPR principles to biomarker discovery in autism and critically review empirical studies adopting these principles. Using a scoping review methodology, we identified and evaluated seven studies using CBPR principles in biomarker discovery. The limited number of studies in biomarker discovery adopting CBPR principles coupled with their methodological limitations suggests that such applications are feasible but challenging. These studies illustrate three CBPR themes: community assessment, setting global priorities, and collaboration in research design. We propose that further research using participatory principles would be useful in accelerating the pace of discovery and the development of clinically meaningful biomarkers. For this goal to be successful we advocate for increased attention to previously identified conceptual and methodological challenges to participatory approaches in health research, including improving scientific rigor and developing long-term partnerships among stakeholders.

[Lean logistics management in healthcare: a case study].

PubMed

Aguilar-Escobar, V G; Garrido-Vega, P

2013-01-01

To study the applicability of the principles of Lean Production to manage the supply chain of a hospital. In particular, to determine which Lean practices and principles are applicable, the benefits obtained and the main barriers for its implementation. Managing the hospital supply chain is an important issue, both for its effect on the quality of care and its impact on costs. This study is based on a case study. 2005-10. Hospital Virgen Macarena in Seville. Process of implementing a comprehensive logistics management plan based on Lean principles and technological investments. The implementation of the comprehensive plan has reduced inventory, decreased lead times and improved service quality. Also, there have been other important improvements: enhanced employee satisfaction and increased staff productivity, both dedicated to health and the logistics. The experience analysed has shown the applicability and appropriateness of Lean principles and some of its techniques in managing the logistics of hospitals. It also identifies some of the main difficulties that may arise. Copyright © 2011 SECA. Published by Elsevier Espana. All rights reserved.

Functional and esthetic outcome enhancement of periodontal surgery by application of plastic surgery principles.

PubMed

Hürzeler, M B; Weng, D

1999-02-01

The closure of surgical wounds in a layer-by-layer fashion, a common principle of plastic surgery, is applied in this article to the field of periodontal surgery with the introduction of a new flap design. The suggested technique is indicated with all periodontal procedures that aim for hard and soft tissue augmentation (guided bone regeneration, mucogingival surgery, or plastic periodontal surgery) where passive, tension-free wound closure is fundamental for wound healing and a successful functional and esthetic outcome. By means of a series of incisions, buccal and lingual flaps are split several times; this results in a double-partial thickness flap and a coronally positioned palatal sliding flap, respectively. Thus, several tissue layers are obtained and the passive advancement of flaps becomes possible for the coverage of augmented areas. Wound closure with microsurgical suture material is accomplished in a multilayer approach, which ensures adaptation and closure of the outer tissue layers without any tension. Two case reports demonstrate the new plastic periodontal approach.

Marginal Bidding: An Application of the Equimarginal Principle to Bidding in TAC SCM

NASA Astrophysics Data System (ADS)

Greenwald, Amy; Naroditskiy, Victor; Odean, Tyler; Ramirez, Mauricio; Sodomka, Eric; Zimmerman, Joe; Cutler, Clark

We present a fast and effective bidding strategy for the Trading Agent Competition in Supply Chain Management (TAC SCM). In TAC SCM, manufacturers compete to procure computer parts from suppliers (the procurement problem), and then sell assembled computers to customers in reverse auctions (the bidding problem). This paper is concerned only with bidding, in which an agent must decide how many computers to sell and at what prices to sell them. We propose a greedy solution, Marginal Bidding, inspired by the Equimarginal Principle, which states that revenue is maximized among possible uses of a resource when the return on the last unit of the resource is the same across all areas of use. We show experimentally that certain variations of Marginal Bidding can compute bids faster than our ILP solution, which enables Marginal Bidders to consider future demand as well as current demand, and hence achieve greater revenues when knowledge of the future is valuable.

Building Capacity for Evidence-Based Public Health: Reconciling the Pulls of Practice and the Push of Research.

PubMed

Brownson, Ross C; Fielding, Jonathan E; Green, Lawrence W

2018-04-01

Timely implementation of principles of evidence-based public health (EBPH) is critical for bridging the gap between discovery of new knowledge and its application. Public health organizations need sufficient capacity (the availability of resources, structures, and workforce to plan, deliver, and evaluate the preventive dose of an evidence-based intervention) to move science to practice. We review principles of EBPH, the importance of capacity building to advance evidence-based approaches, promising approaches for capacity building, and future areas for research and practice. Although there is general agreement among practitioners and scientists on the importance of EBPH, there is less clarity on the definition of evidence, how to find it, and how, when, and where to use it. Capacity for EBPH is needed among both individuals and organizations. Capacity can be strengthened via training, use of tools, technical assistance, assessment and feedback, peer networking, and incentives. Modest investments in EBPH capacity building will foster more effective public health practice.

Building capacity for evidence-based public health: Reconciling the pulls of practice and the push of research

PubMed Central

Fielding, Jonathan E.; Green, Lawrence W.

2018-01-01

Timely implementation of principles of evidence-based public health (EBPH) is critical for bridging the gap between discovery of new knowledge and application. Public health organizations need sufficient capacity (the availability of resources, structures, and workforce to plan deliver and evaluate the “preventive dose” of an evidence-based intervention) to move science to practice. We review principles of EBPH, the importance of capacity building to advance evidence-based approaches, promising approaches for capacity building, and future areas for research and practice. While there is general agreement on the importance of EBPH, there is less clarity on the definition of evidence, how to find it, and how, when and where to use it. Capacity for EBPH is needed among both individuals and organizations. Capacity can be strengthened via training, use of tools, technical assistance, assessment and feedback, peer networking, and incentives. Modest investments in EBPH capacity-building will foster more effective public health practice. PMID:29166243

DNA Charge Transport: From Chemical Principles to the Cell

PubMed Central

Arnold, Anna R.; Grodick, Michael A.; Barton, Jacqueline K.

2016-01-01

The DNA double helix has captured the imagination of many, bringing it to the forefront of biological research. DNA has unique features that extend our interest into areas of chemistry, physics, material science and engineering. Our laboratory has focused on studies of DNA charge transport (CT), wherein charges can efficiently travel long molecular distances through the DNA helix while maintaining an exquisite sensitivity to base pair π-stacking. Because DNA CT chemistry reports on the integrity of the DNA duplex, this property may be exploited to develop electrochemical devices to detect DNA lesions and DNA-binding proteins. Furthermore, studies now indicate that DNA CT may also be used in the cell by, for example, DNA repair proteins, as a cellular diagnostic, in order to scan the genome to localize efficiently to damage sites. In this review, we describe this evolution of DNA CT chemistry from the discovery of fundamental chemical principles to applications in diagnostic strategies and possible roles in biology. PMID:26933744

Future Research in Agile Systems Development: Applying Open Innovation Principles Within the Agile Organisation

NASA Astrophysics Data System (ADS)

Conboy, Kieran; Morgan, Lorraine

A particular strength of agile approaches is that they move away from ‘introverted' development and intimately involve the customer in all areas of development, supposedly leading to the development of a more innovative and hence more valuable information system. However, we argue that a single customer representative is too narrow a focus to adopt and that involvement of stakeholders beyond the software development itself is still often quite weak and in some cases non-existent. In response, we argue that current thinking regarding innovation in agile development needs to be extended to include multiple stakeholders outside the business unit. This paper explores the intra-organisational applicability and implications of open innovation in agile systems development. Additionally, it argues for a different perspective of project management that includes collaboration and knowledge-sharing with other business units, customers, partners, and other relevant stakeholders pertinent to the business success of an organisation, thus embracing open innovation principles.

Polymer therapeutics in surgery: the next frontier

PubMed Central

Conlan, R. Steven; Whitaker, Iain S.

2016-01-01

Abstract Polymer therapeutics is a successful branch of nanomedicine, which is now established in several facets of everyday practice. However, to our knowledge, no literature regarding the application of the underpinning principles, general safety, and potential of this versatile class to the perioperative patient has been published. This study provides an overview of polymer therapeutics applied to clinical surgery, including the evolution of this demand‐oriented scientific field, cutting‐edge concepts, its implications, and limitations, illustrated by products already in clinical use and promising ones in development. In particular, the effect of design of polymer therapeutics on biophysical and biochemical properties, the potential for targeted delivery, smart release, and safety are addressed. Emphasis is made on principles, giving examples in salient areas of demand in current surgical practice. Exposure of the practising surgeon to this versatile class is crucial to evaluate and maximise the benefits that this established field presents and to attract a new generation of clinician–scientists with the necessary knowledge mix to drive highly successful innovation. PMID:27588210

Principles of physics in surgery: the laws of flow dynamics physics for surgeons - Part 1.

PubMed

Srivastava, Anurag; Sood, Akshay; Joy, S Parijat; Woodcock, John

2009-08-01

In the field of medicine and surgery many principles of physics find numerous applications. In this article we have summarized some prominent applications of the laws of fluid mechanics and hydrodynamics in surgery. Poiseuille's law sets the limits of isovolaemic haemodilution, enumerates limiting factors during fluid resuscitation and is a guiding principle in surgery for vascular stenoses. The equation of continuity finds use in non-invasive measurement of blood flow. Bernoulli's theorem explains the formation of post-stenotic dilatation. Reynolds number explains the origin of murmurs, haemolysis and airflow disturbances. Various forms of oxygen therapy are a direct application of the gas laws. Doppler effect is used in ultrasonography to find the direction and velocity of blood flow. In this first part of a series of articles we describe some applications of the laws of hydrodynamics governing the flow of blood and other body fluids.

Structured light optical microscopy for three-dimensional reconstruction of technical surfaces

NASA Astrophysics Data System (ADS)

Kettel, Johannes; Reinecke, Holger; Müller, Claas

2016-04-01

In microsystems technology quality control of micro structured surfaces with different surface properties is playing an ever more important role. The process of quality control incorporates three-dimensional (3D) reconstruction of specularand diffusive reflecting technical surfaces. Due to the demand on high measurement accuracy and data acquisition rates, structured light optical microscopy has become a valuable solution to solve this problem providing high vertical and lateral resolution. However, 3D reconstruction of specular reflecting technical surfaces still remains a challenge to optical measurement principles. In this paper we present a measurement principle based on structured light optical microscopy which enables 3D reconstruction of specular- and diffusive reflecting technical surfaces. It is realized using two light paths of a stereo microscope equipped with different magnification levels. The right optical path of the stereo microscope is used to project structured light onto the object surface. The left optical path is used to capture the structured illuminated object surface with a camera. Structured light patterns are generated by a Digital Light Processing (DLP) device in combination with a high power Light Emitting Diode (LED). Structured light patterns are realized as a matrix of discrete light spots to illuminate defined areas on the object surface. The introduced measurement principle is based on multiple and parallel processed point measurements. Analysis of the measured Point Spread Function (PSF) by pattern recognition and model fitting algorithms enables the precise calculation of 3D coordinates. Using exemplary technical surfaces we demonstrate the successful application of our measurement principle.

Application of an Artificial Stomach-Duodenum Reduced Gastric pH Dog Model for Formulation Principle Assessment and Mechanistic Performance Understanding.

PubMed

Lee, Chen-Ming; Luner, Paul E; Locke, Karen; Briggs, Katherine

2017-08-01

The objective of this study was to develop an artificial stomach-duodenum (ASD) dissolution model as an in vitro evaluation tool that would simulate the gastrointestinal physiology of gastric pH-reduced dogs as a method to assess formulations for a poorly soluble free acid compound with ng/mL solubility. After establishing the ASD model with well-controlled duodenum pH, 5 formulations each applying different solubilization principles were developed and their performance in the ASD model and in vivo in dogs was evaluated. Excellent correlations were obtained between dog area under the curve (AUC) and ASD AUC of 5 formulations evaluated with simulated intestinal fluid (r 2  = 0.987) and fasted-state simulated intestinal fluid (r 2  = 0.989) as the duodenum dissolution medium, indicating that the approach of infusing NaOH into duodenum compartment to maintain duodenum pH of an ASD worked properly in simulating gastric pH-reduced dog. Raman spectroscopy was used to study drug dissolution kinetics associated with different solubilization principles and the results suggested that the solubilization principles performed as designed. Spectroscopic results also identified that the compound formed a gel during dissolution and hypromellose maintained the drug-gelled state to avoid further solid form conversion. The implication of the compound physical gelation to drug dissolution kinetics and in vivo exposure are discussed. Copyright © 2017 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

Application of the coplanar principle to dynamic epidural pressure measurements.

PubMed

Beck, J; Schettini, A; Salton, R

1984-10-01

The application of the coplanar principle to dynamic epidural pressure measurements was investigated in vitro. The authors used a coplanar pressure-displacement transducer, commonly employed to measure the viscoelastic properties of brain tissue in vivo. The present studies were performed using canine dura and a specially constructed fluid-filled chamber. The accuracy of the technique was assessed by comparing the pressure in the chamber recorded by the coplanar transducer to the pressure measured by a transducer directly vented to the chamber. The results show that the coplanar principle remained valid for dynamic measurements with the transducer under a variety of conditions.

Engineering derivatives from biological systems for advanced aerospace applications

NASA Technical Reports Server (NTRS)

Winfield, Daniel L.; Hering, Dean H.; Cole, David

1991-01-01

The present study consisted of a literature survey, a survey of researchers, and a workshop on bionics. These tasks produced an extensive annotated bibliography of bionics research (282 citations), a directory of bionics researchers, and a workshop report on specific bionics research topics applicable to space technology. These deliverables are included as Appendix A, Appendix B, and Section 5.0, respectively. To provide organization to this highly interdisciplinary field and to serve as a guide for interested researchers, we have also prepared a taxonomy or classification of the various subelements of natural engineering systems. Finally, we have synthesized the results of the various components of this study into a discussion of the most promising opportunities for accelerated research, seeking solutions which apply engineering principles from natural systems to advanced aerospace problems. A discussion of opportunities within the areas of materials, structures, sensors, information processing, robotics, autonomous systems, life support systems, and aeronautics is given. Following the conclusions are six discipline summaries that highlight the potential benefits of research in these areas for NASA's space technology programs.

Translational systems biology: introduction of an engineering approach to the pathophysiology of the burn patient.

PubMed

An, Gary; Faeder, James; Vodovotz, Yoram

2008-01-01

The pathophysiology of the burn patient manifests the full spectrum of the complexity of the inflammatory response. In the acute phase, inflammation may have negative effects via capillary leak, the propagation of inhalation injury, and development of multiple organ failure. Attempts to mediate these processes remain a central subject of burn care research. Conversely, inflammation is a necessary prologue and component in the later stage processes of wound healing. Despite the volume of information concerning the cellular and molecular processes involved in inflammation, there exists a significant gap between the knowledge of mechanistic pathophysiology and the development of effective clinical therapeutic regimens. Translational systems biology (TSB) is the application of dynamic mathematical modeling and certain engineering principles to biological systems to integrate mechanism with phenomenon and, importantly, to revise clinical practice. This study will review the existing applications of TSB in the areas of inflammation and wound healing, relate them to specific areas of interest to the burn community, and present an integrated framework that links TSB with traditional burn research.

Hydrogen adsorption in metal-decorated silicon carbide nanotubes

NASA Astrophysics Data System (ADS)

Singh, Ram Sevak; Solanki, Ankit

2016-09-01

Hydrogen storage for fuel cell is an active area of research and appropriate materials with excellent hydrogen adsorption properties are highly demanded. Nanotubes, having high surface to volume ratio, are promising storage materials for hydrogen. Recently, silicon carbide nanotubes have been predicted as potential materials for future hydrogen storage application, and studies in this area are ongoing. Here, we report a systematic study on hydrogen adsorption properties in metal (Pt, Ni and Al) decorated silicon carbide nanotubes (SiCNTs) using first principles calculations based on density functional theory. The hydrogen adsorption properties are investigated by calculations of adsorption energy, electronic band structure, density of states (DOS) and Mulliken charge population analysis. Our findings show that hydrogen adsorptions on Pt, Ni and Al-decorated SiCNTs undergo spontaneous exothermic reactions with significant modulation of electronic structure of SiCNTs in all cases. Importantly, according to the Mulliken charge population analysis, dipole-dipole interaction causes chemisorptions of hydrogen in Pt, Ni and Al decorated SiCNTs with formation of chemical bonds. The study is a platform for the development of metal decorated SiCNTs for hydrogen adsorption or hydrogen storage application.

The 'four principles of bioethics' as found in 13th century Muslim scholar Mawlana's teachings

PubMed Central

Aksoy, Sahin; Tenik, Ali

2002-01-01

Background There have been different ethical approaches to the issues in the history of philosophy. Two American philosophers Beachump and Childress formulated some ethical principles namely 'respect to autonomy', 'justice', 'beneficence' and 'non-maleficence'. These 'Four Principles' were presented by the authors as universal and applicable to any culture and society. Mawlana, a great figure in Sufi tradition, had written many books which not only guide people how to worship God to be close to Him, but also advise people how to lead a good life to enrich their personality, as well as to create a harmonious society and a peaceful world. Methods In this study we examined the major works of Mawlana to find out which of these 'Four Principles of Bioethics' exist in Mawlana's ethical understanding. Results We have found in our study that all these principles exist in Mawlana's writings and philosophy in one form or another. Conclusions We have concluded that, further to Beachump and Childress' claim that these principles are universal and applicable to any culture and society, these principles have always existed in different moral traditions in different ways, of which Mawlana's teaching might be presented as a good example. PMID:12370082

Modelling non-equilibrium thermodynamic systems from the speed-gradient principle.

PubMed

Khantuleva, Tatiana A; Shalymov, Dmitry S

2017-03-06

The application of the speed-gradient (SG) principle to the non-equilibrium distribution systems far away from thermodynamic equilibrium is investigated. The options for applying the SG principle to describe the non-equilibrium transport processes in real-world environments are discussed. Investigation of a non-equilibrium system's evolution at different scale levels via the SG principle allows for a fresh look at the thermodynamics problems associated with the behaviour of the system entropy. Generalized dynamic equations for finite and infinite number of constraints are proposed. It is shown that the stationary solution to the equations, resulting from the SG principle, entirely coincides with the locally equilibrium distribution function obtained by Zubarev. A new approach to describe time evolution of systems far from equilibrium is proposed based on application of the SG principle at the intermediate scale level of the system's internal structure. The problem of the high-rate shear flow of viscous fluid near the rigid plane plate is discussed. It is shown that the SG principle allows closed mathematical models of non-equilibrium processes to be constructed.This article is part of the themed issue 'Horizons of cybernetical physics'. © 2017 The Author(s).

Modelling non-equilibrium thermodynamic systems from the speed-gradient principle

NASA Astrophysics Data System (ADS)

Khantuleva, Tatiana A.; Shalymov, Dmitry S.

2017-03-01

The application of the speed-gradient (SG) principle to the non-equilibrium distribution systems far away from thermodynamic equilibrium is investigated. The options for applying the SG principle to describe the non-equilibrium transport processes in real-world environments are discussed. Investigation of a non-equilibrium system's evolution at different scale levels via the SG principle allows for a fresh look at the thermodynamics problems associated with the behaviour of the system entropy. Generalized dynamic equations for finite and infinite number of constraints are proposed. It is shown that the stationary solution to the equations, resulting from the SG principle, entirely coincides with the locally equilibrium distribution function obtained by Zubarev. A new approach to describe time evolution of systems far from equilibrium is proposed based on application of the SG principle at the intermediate scale level of the system's internal structure. The problem of the high-rate shear flow of viscous fluid near the rigid plane plate is discussed. It is shown that the SG principle allows closed mathematical models of non-equilibrium processes to be constructed. This article is part of the themed issue 'Horizons of cybernetical physics'.

Modelling non-equilibrium thermodynamic systems from the speed-gradient principle

PubMed Central

Khantuleva, Tatiana A.

2017-01-01

The application of the speed-gradient (SG) principle to the non-equilibrium distribution systems far away from thermodynamic equilibrium is investigated. The options for applying the SG principle to describe the non-equilibrium transport processes in real-world environments are discussed. Investigation of a non-equilibrium system's evolution at different scale levels via the SG principle allows for a fresh look at the thermodynamics problems associated with the behaviour of the system entropy. Generalized dynamic equations for finite and infinite number of constraints are proposed. It is shown that the stationary solution to the equations, resulting from the SG principle, entirely coincides with the locally equilibrium distribution function obtained by Zubarev. A new approach to describe time evolution of systems far from equilibrium is proposed based on application of the SG principle at the intermediate scale level of the system's internal structure. The problem of the high-rate shear flow of viscous fluid near the rigid plane plate is discussed. It is shown that the SG principle allows closed mathematical models of non-equilibrium processes to be constructed. This article is part of the themed issue ‘Horizons of cybernetical physics’. PMID:28115617

Accounting principles, reporting rules, and payment practices.

PubMed

Kovener, R R

1979-12-01

Misconceptions concerning the distinction between accounting principles, reporting rules, and payment practices and how they interrelate can lessen the effectiveness of hospital financial managers in these areas/clarification and recommendations are offered.

Application of Theories, Principles and Methods of Adult Learning for Managers to Improve Workplace Reactions to Learning, Knowledge and Performance

ERIC Educational Resources Information Center

Steier, E. Joseph, III

2010-01-01

The objective of this dissertation was to explore the concept that knowledge and application of theories, principles and methods of adult learning to teaching may be a core management competency needed for companies to improve employee reaction to learning, knowledge transfer and behavior as well as engagement, retention and profitability.…

Academy of Nutrition and Dietetics: Standards of professional performance for Registered Dietitian Nutritionists (Competent, Proficient, and Expert) in Sustainable, Resilient, and Healthy Food and Water Systems.

PubMed

Tagtow, Angie; Robien, Kim; Bergquist, Erin; Bruening, Meg; Dierks, Lisa; Hartman, Barbara E; Robinson-O'Brien, Ramona; Steinitz, Tamara; Tahsin, Bettina; Underwood, Teri; Wilkins, Jennifer

2014-03-01

Sustainability is the ability of a system to be maintained over the long term. Resilience is the ability of a system to withstand disturbances and continue to function in a sustainable manner. Issues of sustainability and resilience apply to all aspects of nutrition and dietetics practice, can be practiced at both the program and systems level, and are broader than any one specific practice setting or individual intervention. Given an increasing need to apply principles of sustainability and resilience to nutrition and dietetics practice, as well as growing interest among the public and by Registered Dietitian Nutritionists of health issues related to food and water systems, the Hunger and Environmental Nutrition Dietetic Practice Group, with guidance from the Academy of Nutrition and Dietetics Quality Management Committee, has developed the Standards of Professional Performance as a tool for Registered Dietitian Nutritionists working in sustainable, resilient, and healthy food and water systems to assess their current skill levels and to identify areas for further professional development in this emerging practice area. This Standards of Professional Performance document covers six standards of professional performance: quality in practice, competence and accountability, provision of services, application of research, communication and application of knowledge, and utilization and management of resources. Within each standard, specific indicators provide measurable action statements that illustrate how sustainable, resilient, and healthy food and water systems principles can be applied to practice. The indicators describe three skill levels (competent, proficient, and expert) for Registered Dietitian Nutritionists working in sustainable, resilient, and healthy food and water systems. Copyright © 2014 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.

Combining Experiments and Simulations Using the Maximum Entropy Principle

PubMed Central

Boomsma, Wouter; Ferkinghoff-Borg, Jesper; Lindorff-Larsen, Kresten

2014-01-01

A key component of computational biology is to compare the results of computer modelling with experimental measurements. Despite substantial progress in the models and algorithms used in many areas of computational biology, such comparisons sometimes reveal that the computations are not in quantitative agreement with experimental data. The principle of maximum entropy is a general procedure for constructing probability distributions in the light of new data, making it a natural tool in cases when an initial model provides results that are at odds with experiments. The number of maximum entropy applications in our field has grown steadily in recent years, in areas as diverse as sequence analysis, structural modelling, and neurobiology. In this Perspectives article, we give a broad introduction to the method, in an attempt to encourage its further adoption. The general procedure is explained in the context of a simple example, after which we proceed with a real-world application in the field of molecular simulations, where the maximum entropy procedure has recently provided new insight. Given the limited accuracy of force fields, macromolecular simulations sometimes produce results that are at not in complete and quantitative accordance with experiments. A common solution to this problem is to explicitly ensure agreement between the two by perturbing the potential energy function towards the experimental data. So far, a general consensus for how such perturbations should be implemented has been lacking. Three very recent papers have explored this problem using the maximum entropy approach, providing both new theoretical and practical insights to the problem. We highlight each of these contributions in turn and conclude with a discussion on remaining challenges. PMID:24586124

Students' Conceptions of Underlying Principles in Medical Physiology: An Interview Study of Medical Students' Understanding in a PBL Curriculum

ERIC Educational Resources Information Center

Fyrenius, Anna; Silen, Charlotte; Wirell, Staffan

2007-01-01

Medical physiology is known to be a complex area where students develop significant errors in conceptual understanding. Students' knowledge is often bound to situational descriptions rather than underlying principles. This study explores how medical students discern and process underlying principles in physiology. Indepth interviews, where…

Other Questions with Respect to the Weak Equivalence Principle

NASA Astrophysics Data System (ADS)

Smarandache, Florentin

2017-01-01

A disc rotating at high speed will exert out-of-plane forces resembling an accelerating field. Is the principle of equivalence also applicable for this process? Will someone inside an elevator in free-fall and rotating around its vertical centre, feel a gravitational force? Or will he feel a gravitational force larger than what equivalence principle requires? Does the equivalence principle remain applicable here? An airplane flies at an altitude of 1 km. The co-pilot drops an elevator-room without a passenger inside it. After one second has elapsed, the co-pilot drops four grenades in the direction of the freely-falling elevator's path. The question: Will the grenades reach the elevator before it reaches the ground? If no, why? If yes, which grenade? How will the air resistance influence the outcome?

Bilingual Evidence against the Principle of Contrast.

ERIC Educational Resources Information Center

Quay, Suzanne

Prior research on early lexical acquisition in bilingual infants has been used by Clark (1987) to support the Principle of Contrast, which states that every two forms contrast in meaning. In this study of an English-Spanish bilingual child, it is argued that the Principle of Contrast is not applicable to bilingual acquisition in general. Daily…

29 CFR 1608.1 - Statement of purpose.

Code of Federal Regulations, 2010 CFR

2010-07-01

... upon the principles of title VII. Any uncertainty as to the meaning and application of title VII in... Commission believes that it is now necessary to clarify and harmonize the principles of title VII in order to... who comply with the principles of title VII. (b) Purposes of title VII. Congress enacted title VII in...

77 FR 68130 - Agency Information Collection Activities; Proposed Collection; Comment Request; Voluntary Hazard...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-15

... Critical Control Point (HACCP) principles to reduce the risk of foodborne illness in the operation of... Control Number 0910-0578)--Extension HACCP principles are designed to reduce the occurrence of foodborne... manuals that interpret and promote the application of HACCP principles to reduce the risk of foodborne...

75 FR 53639 - Best Practices for Transit, Transshipment, and Reexport of Items Subject to the Export...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-01

... principles and best practices that complement those already identified by BIS in its Web guidance ( http://www.bis.doc.gov/complianceandenforcement/emcp.htm ), and industry outreach regarding export management... application to the EAR. Principles These best practices are based on the following four principles: Industry...

Using Axline's Eight Principles of Play Therapy with Mexican-American Children

ERIC Educational Resources Information Center

Ramirez, Sylvia Z.; Flores-Torres, Leila L.; Kranz, Peter L.; Lund, Nick L.

2005-01-01

There is a paucity of literature on the application of client-centered play therapy to diverse cultures. In this regard, the purpose of the article is to discuss considerations related to using Axline's eight principles of play therapy with Mexican-American children. The principles involve multicultural acceptance and understanding, relationship…

20 CFR 1002.194 - Can the application of the escalator principle result in adverse consequences when the employee...

Code of Federal Regulations, 2010 CFR

2010-04-01

... principle result in adverse consequences when the employee is reemployed? 1002.194 Section 1002.194... principle result in adverse consequences when the employee is reemployed? Yes. The Act does not prohibit lawful adverse job consequences that result from the employee's restoration on the seniority ladder...

Application of the principle of similarity fluid mechanics

NASA Technical Reports Server (NTRS)

Hendericks, R. C.; Sengers, J. V.

1979-01-01

The principle of similarity applied to fluid mechanics is described and illustrated. The concept of transforming the conservation equations by combining similarity principles for thermophysical properties with those for fluid flow is examined. The usefulness of the procedure is illustrated by applying such a transformation to calculate two phase critical mass flow through a nozzle.

Precautionary Principles: General Definitions and Specific Applications to Genetically Modified Organisms

ERIC Educational Resources Information Center

Lofstedt, Ragnar E.; Fischhoff, Baruch; Fischhoff, Ilya R.

2002-01-01

Precautionary principles have been proposed as a fundamental element of sound risk management. Their advocates see them as guiding action in the face of uncertainty, encouraging the adoption of measures that reduce serious risks to health, safety, and the environment. Their opponents may reject the very idea of precautionary principles, find…

Application of ion-sensitive sensors in water quality monitoring.

PubMed

Winkler, S; Rieger, L; Saracevic, E; Pressl, A; Gruber, G

2004-01-01

Within the last years a trend towards in-situ monitoring can be observed, i.e. most new sensors for water quality monitoring are designed for direct installation in the medium, compact in size and use measurement principles which minimise maintenance demand. Ion-sensitive sensors (Ion-Sensitive-Electrode--ISE) are based on a well known measurement principle and recently some manufacturers have released probe types which are specially adapted for application in water quality monitoring. The function principle of ISE-sensors, their advantages, limitations and the different methods for sensor calibration are described. Experiences with ISE-sensors from applications in sewer networks, at different sampling points within wastewater treatment plants and for surface water monitoring are reported. An estimation of investment and operation costs in comparison to other sensor types is given.

Porous organic cages

NASA Astrophysics Data System (ADS)

Tozawa, Tomokazu; Jones, James T. A.; Swamy, Shashikala I.; Jiang, Shan; Adams, Dave J.; Shakespeare, Stephen; Clowes, Rob; Bradshaw, Darren; Hasell, Tom; Chong, Samantha Y.; Tang, Chiu; Thompson, Stephen; Parker, Julia; Trewin, Abbie; Bacsa, John; Slawin, Alexandra M. Z.; Steiner, Alexander; Cooper, Andrew I.

2009-12-01

Porous materials are important in a wide range of applications including molecular separations and catalysis. We demonstrate that covalently bonded organic cages can assemble into crystalline microporous materials. The porosity is prefabricated and intrinsic to the molecular cage structure, as opposed to being formed by non-covalent self-assembly of non-porous sub-units. The three-dimensional connectivity between the cage windows is controlled by varying the chemical functionality such that either non-porous or permanently porous assemblies can be produced. Surface areas and gas uptakes for the latter exceed comparable molecular solids. One of the cages can be converted by recrystallization to produce either porous or non-porous polymorphs with apparent Brunauer-Emmett-Teller surface areas of 550 and 23m2g-1, respectively. These results suggest design principles for responsive porous organic solids and for the modular construction of extended materials from prefabricated molecular pores.

Infrared coagulation in the treatment of condyloma acuminata in the female genital tract.

PubMed

Bekassy, Z; Weström, L

1987-01-01

An infrared contact coagulator was used for the treatment of genital condyloma acuminata in 89 women. After direct application to the condyloma, the device produces a precisely adjustable tissue necrosis without tissue adhesion. Of the 89 women, 74 returned for scheduled follow-up visits after one, three, and six months. Treatment failure, i.e., recurrence of warts in a treated area, was seen in 13 (10.8%) of 120 treated areas, or in 13 (17.6%) of 74 patients. No complications were observed. The physical working principle of infrared coagulation as well as the results in treatment of condyloma are the same as those of the CO2 laser, but the equipment is cheaper, safer, and more easily handled. It can be used in out-patient departments of clinical and general practices.

Quantum enhanced feedback cooling of a mechanical oscillator using nonclassical light.

PubMed

Schäfermeier, Clemens; Kerdoncuff, Hugo; Hoff, Ulrich B; Fu, Hao; Huck, Alexander; Bilek, Jan; Harris, Glen I; Bowen, Warwick P; Gehring, Tobias; Andersen, Ulrik L

2016-11-29

Laser cooling is a fundamental technique used in primary atomic frequency standards, quantum computers, quantum condensed matter physics and tests of fundamental physics, among other areas. It has been known since the early 1990s that laser cooling can, in principle, be improved by using squeezed light as an electromagnetic reservoir; while quantum feedback control using a squeezed light probe is also predicted to allow improved cooling. Here we show the implementation of quantum feedback control of a micro-mechanical oscillator using squeezed probe light. This allows quantum-enhanced feedback cooling with a measurement rate greater than it is possible with classical light, and a consequent reduction in the final oscillator temperature. Our results have significance for future applications in areas ranging from quantum information networks, to quantum-enhanced force and displacement measurements and fundamental tests of macroscopic quantum mechanics.

Dark current suppression of MgZnO metal-semiconductor-metal solar-blind ultraviolet photodetector by asymmetric electrode structures.

PubMed

Wang, Ping; Zheng, Qinghong; Tang, Qing; Yang, Yintang; Guo, Lixin; Huang, Feng; Song, Zhenjie; Zhang, Zhiyong

2014-01-15

The application of asymmetric Schottky barrier and electrode area in an MgZnO metal-semiconductor-metal (MSM) solar-blind ultraviolet photodetector has been investigated by a physical-based numerical model in which the electron mobility is obtained by an ensemble Monte Carlo simulation combined with first principle calculations using the density functional theory. Compared with the experimental data of symmetric and asymmetric MSM structures based on ZnO substrate, the validity of this model is verified. The asymmetric Schottky barrier and electrode area devices exhibit reductions of 20 times and 1.3 times on dark current, respectively, without apparent photocurrent scarification. The plots of photo-to-dark current ratio (PDR) indicate that the asymmetric MgZnO MSM structure has better dark current characteristic than that of the symmetric one.

Climate-sensitive urban design through Envi-Met simulation: case study in Kemayoran, Jakarta

NASA Astrophysics Data System (ADS)

Kusumastuty, K. D.; Poerbo, H. W.; Koerniawan, M. D.

2018-03-01

Indonesia as a tropical country which the character of its climate are hot and humid, the outdoor activity applications are often disrupted due to discomfort in thermal conditions. Massive construction of skyscrapers in urban areas are caused by the increase of human population leads to reduced green and infiltration areas that impact to environmental imbalances and triggering microclimate changes with rising air temperatures on the surface. The area that significantly experiences the rise of temperature in the Central Business District (CBD), which has need an analysis to create thermal comfort conditions to improve the ease of outdoor activities by an approach. This study aims to design the Kemayoran CBD through Climate Sensitive Urban Design especially in hot and humid tropical climate area and analyze thermal comfort level and optimal air conditioning in the outdoor area. This research used a quantitative method by generating the design using Climate Sensitive Urban Design principle through Envi-met 4.1 simulation program to find out the value of PMV, air temperature, wind speed and relative humidity conditions. The design area considers the configuration of buildings such as the distance between buildings, the average height, the orientation of the building, and the width of the road.

On Babinet's principle and diffraction associated with an arbitrary particle.

PubMed

Sun, Bingqiang; Yang, Ping; Kattawar, George W; Mishchenko, Michael I

2017-12-01

Babinet's principle is widely used to compute the diffraction by a particle. However, the diffraction by a 3-D object is not totally the same as that simulated with Babinet's principle. This Letter uses a surface integral equation to exactly formulate the diffraction by an arbitrary particle and illustrate the condition for the applicability of Babinet's principle. The present results may serve to close the debate on the diffraction formalism.

Direct Linearization and Adjoint Approaches to Evaluation of Atmospheric Weighting Functions and Surface Partial Derivatives: General Principles, Synergy and Areas of Application

NASA Technical Reports Server (NTRS)

Ustino, Eugene A.

2006-01-01

This slide presentation reviews the observable radiances as functions of atmospheric parameters and of surface parameters; the mathematics of atmospheric weighting functions (WFs) and surface partial derivatives (PDs) are presented; and the equation of the forward radiative transfer (RT) problem is presented. For non-scattering atmospheres this can be done analytically, and all WFs and PDs can be computed analytically using the direct linearization approach. For scattering atmospheres, in general case, the solution of the forward RT problem can be obtained only numerically, but we need only two numerical solutions: one of the forward RT problem and one of the adjoint RT problem to compute all WFs and PDs we can think of. In this presentation we discuss applications of both the linearization and adjoint approaches

AVALON: definition and modeling of a vertical takeoff and landing UAV

NASA Astrophysics Data System (ADS)

Silva, N. B. F.; Marconato, E. A.; Branco, K. R. L. J. C.

2015-09-01

Unmanned Aerial Vehicles (UAVs) have been used in numerous applications, like remote sensing, precision agriculture and atmospheric data monitoring. Vertical takeoff and landing (VTOL) is a modality of these aircrafts, which are capable of taking off and landing vertically, like a helicopter. This paper presents the definition and modeling of a fixed- wing VTOL, named AVALON (Autonomous VerticAL takeOff and laNding), which has the advantages of traditional aircrafts with improved performance and can take off and land in small areas. The principles of small UAVs development were followed to achieve a better design and to increase the range of applications for this VTOL. Therefore, we present the design model of AVALON validated in a flight simulator and the results show its validity as a physical option for an UAV platform.

Effect of polarization self-action in cubic crystals: peculiarities and applications

NASA Astrophysics Data System (ADS)

Boiko, Sergei A.; Lisitsa, Mikhail P.; Tarasov, Georgiy G.; Valakh, Mikhail Y.

1995-04-01

New concepts are developed to describe a wide area of nonlinear systems involving the phase relaxation peculiarities for the degenerate two- level system under the resonant optical excitation. Nonlinear susceptibility of the two-level system becomes anisotropic, and self- induced changes of polarization (SICP) are developed to the large (gigantic) magnitudes. The nonlinearities of two different natures are considered: the saturation of absorption and the resonant optical reorientation of anisotropic defects. For these particular cases, the SICP effects manifest themselves at a field much lower than that in traditional nonlinear optics. The larger magnitudes of the effects offer good possibilities for the development of optical devices based on the new physical principles. Various applications of SICP effects are demonstrated, including the spectroscopic investigations of impure cubic crystals, optical diagnostics, optical storage, information processing, and the development of new optical devices.

Photogrammetry and remote sensing education subjects

NASA Astrophysics Data System (ADS)

Lazaridou, Maria A.; Karagianni, Aikaterini Ch.

2017-09-01

The rapid technologic advances in the scientific areas of photogrammetry and remote sensing require continuous readjustments at the educational programs and their implementation. The teaching teamwork should deal with the challenge to offer the volume of the knowledge without preventing the understanding of principles and methods and also to introduce "new" knowledge (advances, trends) followed by evaluation and presentation of relevant applications. This is of particular importance for a Civil Engineering Faculty as this in Aristotle University of Thessaloniki, as the framework of Photogrammetry and Remote Sensing is closely connected with applications in the four educational Divisions of the Faculty. This paper refers to the above and includes subjects of organizing the courses in photogrammetry and remote sensing in the Civil Engineering Faculty of Aristotle University of Thessaloniki. A scheme of the general curriculum as well the teaching aims and methods are also presented.

The construct of resilience: Implications for interventions and social policies

PubMed Central

LUTHAR, SUNIYA S.; CICCHETTI, DANTE

2007-01-01

The focus of this article is on the interface between research on resilience—a construct representing positive adaptation despite adversity —and the applications of this work to the development of interventions and social policies. Salient defining features of research on resilience are delineated, as are various advantages, limitations, and precautions linked with the application of the resilience framework to developing interventions. For future applied efforts within this tradition, a series of guiding principles are presented along with exemplars of existing programs based on the resilience paradigm. The article concludes with discussions of directions for future work in this area, with emphases on an enhanced interface between science and practice, and a broadened scope of resilience-based interventions in terms of the types of populations, and the types of adjustment domains, that are encompassed. PMID:11202047

Weak Bond-Based Injectable and Stimuli Responsive Hydrogels for Biomedical Applications

PubMed Central

Ding, Xiaochu; Wang, Yadong

2017-01-01

Here we define hydrogels crosslinked by weak bonds as physical hydrogels. They possess unique features including reversible bonding, shear thinning and stimuli-responsiveness. Unlike covalently crosslinked hydrogels, physical hydrogels do not require triggers to initiate chemical reactions for in situ gelation. The drug can be fully loaded in a pre-formed hydrogel for delivery with minimal cargo leakage during injection. These benefits make physical hydrogels useful as delivery vehicles for applications in biomedical engineering. This review focuses on recent advances of physical hydrogels crosslinked by weak bonds: hydrogen bonds, ionic interactions, host-guest chemistry, hydrophobic interactions, coordination bonds and π-π stacking interactions. Understanding the principles and the state of the art of gels with these dynamic bonds may give rise to breakthroughs in many biomedical research areas including drug delivery and tissue engineering. PMID:29062484

Ultrasound Imaging Velocimetry: a review

NASA Astrophysics Data System (ADS)

Poelma, Christian

2017-01-01

Whole-field velocity measurement techniques based on ultrasound imaging (a.k.a. `ultrasound imaging velocimetry' or `echo-PIV') have received significant attention from the fluid mechanics community in the last decade, in particular because of their ability to obtain velocity fields in flows that elude characterisation by conventional optical methods. In this review, an overview is given of the history, typical components and challenges of these techniques. The basic principles of ultrasound image formation are summarised, as well as various techniques to estimate flow velocities; the emphasis is on correlation-based techniques. Examples are given for a wide range of applications, including in vivo cardiovascular flow measurements, the characterisation of sediment transport and the characterisation of complex non-Newtonian fluids. To conclude, future opportunities are identified. These encompass not just optimisation of the accuracy and dynamic range, but also extension to other application areas.

Textile-Based Electronic Components for Energy Applications: Principles, Problems, and Perspective

PubMed Central

Kaushik, Vishakha; Lee, Jaehong; Hong, Juree; Lee, Seulah; Lee, Sanggeun; Seo, Jungmok; Mahata, Chandreswar; Lee, Taeyoon

2015-01-01

Textile-based electronic components have gained interest in the fields of science and technology. Recent developments in nanotechnology have enabled the integration of electronic components into textiles while retaining desirable characteristics such as flexibility, strength, and conductivity. Various materials were investigated in detail to obtain current conductive textile technology, and the integration of electronic components into these textiles shows great promise for common everyday applications. The harvest and storage of energy in textile electronics is a challenge that requires further attention in order to enable complete adoption of this technology in practical implementations. This review focuses on the various conductive textiles, their methods of preparation, and textile-based electronic components. We also focus on fabrication and the function of textile-based energy harvesting and storage devices, discuss their fundamental limitations, and suggest new areas of study. PMID:28347078

Textile-Based Electronic Components for Energy Applications: Principles, Problems, and Perspective.

PubMed

Kaushik, Vishakha; Lee, Jaehong; Hong, Juree; Lee, Seulah; Lee, Sanggeun; Seo, Jungmok; Mahata, Chandreswar; Lee, Taeyoon

2015-09-07

Textile-based electronic components have gained interest in the fields of science and technology. Recent developments in nanotechnology have enabled the integration of electronic components into textiles while retaining desirable characteristics such as flexibility, strength, and conductivity. Various materials were investigated in detail to obtain current conductive textile technology, and the integration of electronic components into these textiles shows great promise for common everyday applications. The harvest and storage of energy in textile electronics is a challenge that requires further attention in order to enable complete adoption of this technology in practical implementations. This review focuses on the various conductive textiles, their methods of preparation, and textile-based electronic components. We also focus on fabrication and the function of textile-based energy harvesting and storage devices, discuss their fundamental limitations, and suggest new areas of study.

Marine cloud brightening: regional applications.

PubMed

Latham, John; Gadian, Alan; Fournier, Jim; Parkes, Ben; Wadhams, Peter; Chen, Jack

2014-12-28

The general principle behind the marine cloud brightening (MCB) climate engineering technique is that seeding marine stratocumulus clouds with substantial concentrations of roughly monodisperse sub-micrometre-sized seawater particles might significantly enhance cloud albedo and longevity, thereby producing a cooling effect. This paper is concerned with preliminary studies of the possible beneficial application of MCB to three regional issues: (1) recovery of polar ice loss, (2) weakening of developing hurricanes and (3) elimination or reduction of coral bleaching. The primary focus is on Item 1. We focus discussion herein on advantages associated with engaging in limited-area seeding, regional effects rather than global; and the levels of seeding that may be required to address changing current and near-term conditions in the Arctic. We also mention the possibility that MCB might be capable of producing a localized cooling to help stabilize the West Antarctic Ice Sheet.

Molecular engineering of sensitizers for dye-sensitized solar cell applications.

PubMed

Giribabu, Lingamallu; Kanaparthi, Ravi Kumar; Velkannan, Veerapandian

2012-06-01

Dye-sensitized solar cells (DSSCs) have attracted considerable attention in recent years as they offer the possibility of low-cost conversion of photovoltaic energy. This account focuses on recent advances in molecular design and technological aspects of sensitizers based on metal complexes, metal-free organics and tetrapyrrolic compounds which include porphyrins, phthalocyanines as well as corroles. Special attention has been paid to the design principles of these dyes, and co-sensitization, an emerging technique to extend the absorption range, is also discussed as a way to improve the performance of the device. This account also focuses on recent advances of efficient ruthenium sensitizers as well as other metal complexes and their applications in DSSCs. Recent developments in the area of metal-free organic and tetrapyrrolic sensitizers are also discussed. Copyright © 2012 The Japan Chemical Journal Forum and Wiley Periodicals, Inc.

Principles and application of shock-tubes and shock tunnels

NASA Technical Reports Server (NTRS)

Ried, R. C.; Clauss, H. G., Jr.

1963-01-01

The principles, theoretical flow equations, calculation techniques, limitations and practical performance characteristics of basic and high performance shock tubes and shock tunnels are presented. Selected operating curves are included.

Volume II: Ecosystem management: principles and applications.

Treesearch

M.E. Jensen; P.S. Bourgeron

1994-01-01

This document provides land managers with practical suggestions for implementing ecosystem management. It contains 28 papers organized into five sections: historical perspectives, ecological principles, sampling design, case studies, and implementation strategies.

Expanding NASA Science Cooperation with New Partners

NASA Astrophysics Data System (ADS)

Allen, Marc; Bress, Kent

Expanding NASA Science Cooperation with New Partners When NASA was created in 1958, it was given a goal of "cooperation by the United States with other nations and groups of nations in work done pursuant to this Act and in the peaceful application of the results." As science has become increasingly globalized during the past 50 years, NASA and its many partners in space and Earth science research have benefited enormously from pooling ideas, skills, and resources for joint undertakings. The discoveries made have powerfully advanced public awareness of science and its importance all over the world. Today, the U.S. Administra-tion is encouraging NASA to expand its cooperation with new and emerging partners. NASA space and Earth science cooperation is founded on scientist-to-scientist research collaboration. Space missions are very costly and technically challenging, but there are many other important areas for international cooperation. Areas ripe for expansion with new partners include space data sharing, scientist-to-scientist collaborative research, international research program plan-ning and coordination, Earth applications for societal benefit, ground-based measurements for Earth system science, and education and public outreach. This presentation lays out NASA's general principles for international science cooperation, briefly describes each of these opportu-nity areas, and suggests avenues for initiating new cooperative relationships.

ENVIRONMENTAL HYDRAULICS

EPA Science Inventory

The thermal, chemical, and biological quality of water in rivers, lakes, reservoirs, and near coastal areas is inseparable from a consideration of hydraulic engineering principles: therefore, the term environmental hydraulics. In this chapter we discuss the basic principles of w...

2 CFR Appendix A to Part 220 - Principles for Determining Costs Applicable to Grants, Contracts, and Other Agreements With...

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Principles for Determining Costs Applicable to Grants, Contracts, and Other Agreements With Educational Institutions A Appendix A to Part 220 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET CIRCULARS AND GUIDANCE Reserve...

2 CFR Appendix A to Part 220 - Principles for Determining Costs Applicable to Grants, Contracts, and Other Agreements With...

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Principles for Determining Costs Applicable to Grants, Contracts, and Other Agreements With Educational Institutions A Appendix A to Part 220 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET CIRCULARS AND GUIDANCE Reserve...

2 CFR Appendix A to Part 220 - Principles for Determining Costs Applicable to Grants, Contracts, and Other Agreements With...

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Principles for Determining Costs Applicable to Grants, Contracts, and Other Agreements With Educational Institutions A Appendix A to Part 220 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET CIRCULARS AND GUIDANCE Reserve...

Basic principles, methodology, and applications of remote sensing in agriculture

NASA Technical Reports Server (NTRS)

Moreira, M. A. (Principal Investigator); Deassuncao, G. V.

1984-01-01

The basic principles of remote sensing applied to agriculture and the methods used in data analysis are described. Emphasis is placed on the importance of developing a methodology that may help crop forecast, basic concepts of spectral signatures of vegetation, the methodology of the LANDSAT data utilization in agriculture, and the remote sensing program application of INPE (Institute for Space Research) in agriculture.

Enzymes: principles and biotechnological applications

PubMed Central

Robinson, Peter K.

2015-01-01

Enzymes are biological catalysts (also known as biocatalysts) that speed up biochemical reactions in living organisms, and which can be extracted from cells and then used to catalyse a wide range of commercially important processes. This chapter covers the basic principles of enzymology, such as classification, structure, kinetics and inhibition, and also provides an overview of industrial applications. In addition, techniques for the purification of enzymes are discussed. PMID:26504249

Hybrid photonic signal processing

NASA Astrophysics Data System (ADS)

Ghauri, Farzan Naseer

This thesis proposes research of novel hybrid photonic signal processing systems in the areas of optical communications, test and measurement, RF signal processing and extreme environment optical sensors. It will be shown that use of innovative hybrid techniques allows design of photonic signal processing systems with superior performance parameters and enhanced capabilities. These applications can be divided into domains of analog-digital hybrid signal processing applications and free-space---fiber-coupled hybrid optical sensors. The analog-digital hybrid signal processing applications include a high-performance analog-digital hybrid MEMS variable optical attenuator that can simultaneously provide high dynamic range as well as high resolution attenuation controls; an analog-digital hybrid MEMS beam profiler that allows high-power watt-level laser beam profiling and also provides both submicron-level high resolution and wide area profiling coverage; and all optical transversal RF filters that operate on the principle of broadband optical spectral control using MEMS and/or Acousto-Optic tunable Filters (AOTF) devices which can provide continuous, digital or hybrid signal time delay and weight selection. The hybrid optical sensors presented in the thesis are extreme environment pressure sensors and dual temperature-pressure sensors. The sensors employ hybrid free-space and fiber-coupled techniques for remotely monitoring a system under simultaneous extremely high temperatures and pressures.

Instructional Audio Guidelines: Four Design Principles to Consider for Every Instructional Audio Design Effort

ERIC Educational Resources Information Center

Carter, Curtis W.

2012-01-01

This article contends that instructional designers and developers should attend to four particular design principles when creating instructional audio. Support for this view is presented by referencing the limited research that has been done in this area, and by indicating how and why each of the four principles is important to the design process.…

The design guidelines of mobile augmented reality for tourism in Malaysia

NASA Astrophysics Data System (ADS)

Shukri, Saidatul A'isyah Ahmad; Arshad, Haslina; Abidin, Rimaniza Zainal

2017-10-01

Recent data shows that one in every five people in the world owns a Smartphone and spends most of their time on the phone using apps. Visitors prefer this type of portable, convenient, practical and simple technology when travelling, especially geo location-enabled applications such as the GPS. The aim of this paper is to develop design guidelines for Mobile Augmented Reality (MAR) for tourism. From the analysis of existing design guidelines of Mobile Augmented Reality (MAR) for tourism, an application design guidelines are proposed based on Human-computer interaction principle and usability design that would fulfils the user's requirement in a better way. Six design principles were examined in this analysis. The analysis identified eleven suggestions for design principles. These recommendations are offered towards designing principles and developing prototype app for tourist in Malaysia. This paper identifies design principles to reduce cognitive overhead of tourist, learn ability and suitable context for providing content whiles their travel in Malaysia.

41 CFR 101-27.102-2 - Guidelines.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Replenishment § 101-27.102-2 Guidelines. Guidelines for implementing the EOQ principle of stock replenishment are in the GSA Handbook, The Economic Order Quantity Principle and Applications, issued by the Federal...

Management, Ethics and the Military Chaplin.

DTIC Science & Technology

for the rationale that military chaplains should integrate these principles in their work. A practical approach toward the principles of management is suggested and the moral implications of their application is studied. (Author)

Nearfield acoustic holography. I - Theory of generalized holography and the development of NAH

NASA Technical Reports Server (NTRS)

Maynard, J. D.; Williams, E. G.; Lee, Y.

1985-01-01

Because its underlying principles are so fundamental, holography has been studied and applied in many areas of science. Recently, a technique has been developed which takes the maximum advantage of the fundamental principles and extracts much more information from a hologram than is customarily associated with such a measurement. In this paper the fundamental principles of holography are reviewed, and a sound radiation measurement system, called nearfield acoustic holography (NAH), which fully exploits the fundamental principles, is described.

TRIZ theory in NEA photocathode preparation system

NASA Astrophysics Data System (ADS)

Qiao, Jianliang; Huang, Dayong; Li, Xiangjiang; Gao, Youtang

2016-09-01

The solutions to the engineering problems were provided according to the innovation principle based on the theory of TRIZ. The ultra high vacuum test and evaluation system for the preparation of negative electron affinity (NEA) photocathode has the characteristics of complex structure and powerful functions. Segmentation principle, advance function principle, curved surface principle, dynamic characteristics principle and nested principle adopted by the design of ultra high vacuum test and evaluation system for cathode preparation were analyzed. The applications of the physical contradiction and the substance-field analysis method of the theory of TRIZ in the cathode preparation ultra high vacuum test and evaluation system were discussed.

Neurocognitive Brain Response to Transient Impairment of Wernicke's Area

PubMed Central

Mason, Robert A.; Prat, Chantel S.; Just, Marcel Adam

2014-01-01

This study examined how the brain system adapts and reconfigures its information processing capabilities to maintain cognitive performance after a key cortical center [left posterior superior temporal gyrus (LSTGp)] is temporarily impaired during the performance of a language comprehension task. By applying repetitive transcranial magnetic stimulation (rTMS) to LSTGp and concurrently assessing the brain response with functional magnetic resonance imaging, we found that adaptation consisted of 1) increased synchronization between compensating regions coupled with a decrease in synchronization within the primary language network and 2) a decrease in activation at the rTMS site as well as in distal regions, followed by their recovery. The compensatory synchronization included 3 centers: The contralateral homolog (RSTGp) of the area receiving rTMS, areas adjacent to the rTMS site, and a region involved in discourse monitoring (medial frontal gyrus). This approach reveals some principles of network-level adaptation to trauma with potential application to traumatic brain injury, stroke, and seizure. PMID:23322403

Neurocognitive brain response to transient impairment of Wernicke's area.

PubMed

Mason, Robert A; Prat, Chantel S; Just, Marcel Adam

2014-06-01

This study examined how the brain system adapts and reconfigures its information processing capabilities to maintain cognitive performance after a key cortical center [left posterior superior temporal gyrus (LSTGp)] is temporarily impaired during the performance of a language comprehension task. By applying repetitive transcranial magnetic stimulation (rTMS) to LSTGp and concurrently assessing the brain response with functional magnetic resonance imaging, we found that adaptation consisted of 1) increased synchronization between compensating regions coupled with a decrease in synchronization within the primary language network and 2) a decrease in activation at the rTMS site as well as in distal regions, followed by their recovery. The compensatory synchronization included 3 centers: The contralateral homolog (RSTGp) of the area receiving rTMS, areas adjacent to the rTMS site, and a region involved in discourse monitoring (medial frontal gyrus). This approach reveals some principles of network-level adaptation to trauma with potential application to traumatic brain injury, stroke, and seizure.

An Application of Total Quality Principles in Transforming the Culture of Classrooms

ERIC Educational Resources Information Center

Algozzine, Bob; Audette, Robert H.; Marr, Mary Beth; Algozzine, Kate

2005-01-01

During the 1990s, many public schools began to apply the principles of Total Quality Management. As they moved ahead, they discovered that most of the separate principles that comprise Total Quality Management are not new to public education. Theories and practices using similar and related ideas have been championed by educators for generations.…

Erickson for Counselors and Educators: A Review and Practical Application of Six Treatment Principles.

ERIC Educational Resources Information Center

Sahlin, Francine C.

1987-01-01

Six treatment principles of Milton Erickson, physician and hypnotherapist, are applied to counselors and educators. Principles include: (1) People are always responding, always communicating. (2) Respect all messages from the client. (3) People make the best choice for themselves at any given moment. (4) Teach choice; never attempt to take choice…

Application of Merrill's First Principles of Instruction in a Museum Education Context

ERIC Educational Resources Information Center

Nelson, Kari Ross

2015-01-01

In an effort to support a solid grounding in educational theory within the field of museum education, three texts considered essential reading for museum educators were surveyed for correlations with Merrill's First Principles of Instruction, an influential work in the field of instructional design. Each of five First Principles were found to be…

A stochastic maximum principle for backward control systems with random default time

NASA Astrophysics Data System (ADS)

Shen, Yang; Kuen Siu, Tak

2013-05-01

This paper establishes a necessary and sufficient stochastic maximum principle for backward systems, where the state processes are governed by jump-diffusion backward stochastic differential equations with random default time. An application of the sufficient stochastic maximum principle to an optimal investment and capital injection problem in the presence of default risk is discussed.

Circular A-21: Cost Principles for Educational Institutions. NACUBO Special Report 79-4.

ERIC Educational Resources Information Center

National Association of College and University Business Officers, Washington, DC.

The Office of Management and Budget Circular A-21 on cost principles for educational institutions, which was published in the Federal Register on March 6, 1979, is reproduced in its entirety, and a brief introduction by Max A. Binkley is presented. The circular established principles for determining costs applicable to federal grants, contracts,…

A Justification, after the Postmodern Turn, of Universal Ethical Principles and Educational Ideals

ERIC Educational Resources Information Center

Mason, Mark

2005-01-01

The implementation of education programmes in different cultures invites the question whether we are justified in doing so in cultures that may reject the programmes' underlying principles. Are there indeed ethical principles and educational ideals that can be justified as applicable to all cultures? After a consideration of Zygmunt Bauman's…

Fundamentals of Pharmacogenetics in Personalized, Precision Medicine.

PubMed

Valdes, Roland; Yin, DeLu Tyler

2016-09-01

This article introduces fundamental principles of pharmacogenetics as applied to personalized and precision medicine. Pharmacogenetics establishes relationships between pharmacology and genetics by connecting phenotypes and genotypes in predicting the response of therapeutics in individual patients. We describe differences between precision and personalized medicine and relate principles of pharmacokinetics and pharmacodynamics to applications in laboratory medicine. We also review basic principles of pharmacogenetics, including its evolution, how it enables the practice of personalized therapeutics, and the role of the clinical laboratory. These fundamentals are a segue for understanding specific clinical applications of pharmacogenetics described in subsequent articles in this issue. Copyright © 2016 Elsevier Inc. All rights reserved.

Determination of surface layer parameters at the edge of a suburban area

NASA Astrophysics Data System (ADS)

Likso, T.; Pandžić, K.

2012-05-01

Vertical wind and air temperature profile related parameters in the surface layer at the edge of suburban area of Zagreb (Croatia) have been considered. For that purpose, adopted Monin-Obukhov similarity theory and a set of observations of wind and air temperature at 2 and 10 m above ground, recorded in 2005, have been used. The root mean square differences (errors) principle has been used as a tool to estimate the effective roughness length as well as standard deviations of wind speed and wind gusts. The results of estimation are effective roughness lengths dependent on eight wind direction sectors unknown before. Gratefully to that achievement, representativeness of wind data at standard 10-m height can be clarified more deeply for an area of at least about 1 km in upwind direction from the observation site. Extrapolation of wind data for lower or higher levels from standard 10-m height are thus properly representative for a wider inhomogeneous suburban area and can be used as such in numerical models, flux and wind energy estimation, civil engineering, air pollution and climatological applications.

A Comprehensive Prevention Approach to Reducing Assault Offenses and Assault Injuries Among Youth

PubMed Central

Heinze, Justin E.; Reischl, Thomas M.; Bai, Mengqiao; Roche, Jessica S.; Morrel-Samuels, Susan; Cunningham, Rebecca M.; Zimmerman, Marc A.

2018-01-01

Since 2011, the CDC-funded Michigan Youth Violence Prevention Center (MI-YVPC), working with community partners, has implemented a comprehensive prevention approach to reducing youth violence in Flint, MI, based on public health principles. MI-YVPC employed an intervention strategy that capitalizes on existing community resources and application of evidence-based programs using a social-ecological approach to change. We evaluated the combined effect of six programs in reducing assaults and injury among 10–24 year olds in the intervention area relative to a matched comparison community. We used generalized linear mixed models to examine change in the intervention area counts of reported assault offenses and assault injury presentation relative to the comparison area over a period six years prior- and two and a half years post-intervention. Results indicated that youth victimization and assault injuries fell in the intervention area subsequent to the initiation of the interventions and that these reductions were sustained over time. Our evaluation demonstrated that a comprehensive multi-level approach can be effective for reducing youth violence and injury. PMID:26572898

Le Chatelier Principle for Out-of-Equilibrium and Boundary-Driven Systems: Application to Dynamical Phase Transitions.

PubMed

Shpielberg, O; Akkermans, E

2016-06-17

A stability analysis is presented for boundary-driven and out-of-equilibrium systems in the framework of the hydrodynamic macroscopic fluctuation theory. A Hamiltonian description is proposed which allows us to thermodynamically interpret the additivity principle. A necessary and sufficient condition for the validity of the additivity principle is obtained as an extension of the Le Chatelier principle. These stability conditions result from a diagonal quadratic form obtained using the cumulant generating function. This approach allows us to provide a proof for the stability of the weakly asymmetric exclusion process and to reduce the search for stability to the solution of two coupled linear ordinary differential equations instead of nonlinear partial differential equations. Additional potential applications of these results are discussed in the realm of classical and quantum systems.

Le Chatelier Principle for Out-of-Equilibrium and Boundary-Driven Systems: Application to Dynamical Phase Transitions

NASA Astrophysics Data System (ADS)

Shpielberg, O.; Akkermans, E.

2016-06-01

A stability analysis is presented for boundary-driven and out-of-equilibrium systems in the framework of the hydrodynamic macroscopic fluctuation theory. A Hamiltonian description is proposed which allows us to thermodynamically interpret the additivity principle. A necessary and sufficient condition for the validity of the additivity principle is obtained as an extension of the Le Chatelier principle. These stability conditions result from a diagonal quadratic form obtained using the cumulant generating function. This approach allows us to provide a proof for the stability of the weakly asymmetric exclusion process and to reduce the search for stability to the solution of two coupled linear ordinary differential equations instead of nonlinear partial differential equations. Additional potential applications of these results are discussed in the realm of classical and quantum systems.

Supercritical fluid extraction. Principles and practice

DOE Office of Scientific and Technical Information (OSTI.GOV)

McHugh, M.A.; Krukonis, V.J.

This book is a presentation of the fundamentals and application of super-critical fluid solvents (SCF). The authors cover virtually every facet of SCF technology: the history of SCF extraction, its underlying thermodynamic principles, process principles, industrial applications, and analysis of SCF research and development efforts. The thermodynamic principles governing SCF extraction are covered in depth. The often complex three-dimensional pressure-temperature composition (PTx) phase diagrams for SCF-solute mixtures are constructed in a coherent step-by-step manner using the more familiar two-dimensional Px diagrams. The experimental techniques used to obtain high pressure phase behavior information are described in detail and the advantages andmore » disadvantages of each technique are explained. Finally, the equations used to model SCF-solute mixtures are developed, and modeling results are presented to highlight the correlational strengths of a cubic equation of state.« less

Electronic device aspects of neural network memories

NASA Technical Reports Server (NTRS)

Lambe, J.; Moopenn, A.; Thakoor, A. P.

1985-01-01

The basic issues related to the electronic implementation of the neural network model (NNM) for content addressable memories are examined. A brief introduction to the principles of the NNM is followed by an analysis of the information storage of the neural network in the form of a binary connection matrix and the recall capability of such matrix memories based on a hardware simulation study. In addition, materials and device architecture issues involved in the future realization of such networks in VLSI-compatible ultrahigh-density memories are considered. A possible space application of such devices would be in the area of large-scale information storage without mechanical devices.

Standby Rates for Combined Heat and Power Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sedano, Richard; Selecky, James; Iverson, Kathryn

2014-02-01

Improvements in technology, low natural gas prices, and more flexible and positive attitudes in government and utilities are making distributed generation more viable. With more distributed generation, notably combined heat and power, comes an increase in the importance of standby rates, the cost of services utilities provide when customer generation is not operating or is insufficient to meet full load. This work looks at existing utility standby tariffs in five states. It uses these existing rates and terms to showcase practices that demonstrate a sound application of regulatory principles and ones that do not. The paper also addresses areas formore » improvement in standby rates.« less

Photoaffinity labeling in target- and binding-site identification

PubMed Central

Smith, Ewan; Collins, Ian

2015-01-01

Photoaffinity labeling (PAL) using a chemical probe to covalently bind its target in response to activation by light has become a frequently used tool in drug discovery for identifying new drug targets and molecular interactions, and for probing the location and structure of binding sites. Methods to identify the specific target proteins of hit molecules from phenotypic screens are highly valuable in early drug discovery. In this review, we summarize the principles of PAL including probe design and experimental techniques for in vitro and live cell investigations. We emphasize the need to optimize and validate probes and highlight examples of the successful application of PAL across multiple disease areas. PMID:25686004

Dynamic perfusion CT in brain tumors.

PubMed

Yeung, Timothy Pok Chi; Bauman, Glenn; Yartsev, Slav; Fainardi, Enrico; Macdonald, David; Lee, Ting-Yim

2015-12-01

Dynamic perfusion CT (PCT) is an imaging technique for assessing the vascular supply and hemodynamics of brain tumors by measuring blood flow, blood volume, and permeability-surface area product. These PCT parameters provide information complementary to histopathologic assessments and have been used for grading brain tumors, distinguishing high-grade gliomas from other brain lesions, differentiating true progression from post-treatment effects, and predicting prognosis after treatments. In this review, the basic principles of PCT are described, and applications of PCT of brain tumors are discussed. The advantages and current challenges, along with possible solutions, of PCT are presented. Copyright © 2015. Published by Elsevier Ireland Ltd.

On stochastic control and optimal measurement strategies. Ph.D. Thesis

NASA Technical Reports Server (NTRS)

Kramer, L. C.

1971-01-01

The control of stochastic dynamic systems is studied with particular emphasis on those which influence the quality or nature of the measurements which are made to effect control. Four main areas are discussed: (1) the meaning of stochastic optimality and the means by which dynamic programming may be applied to solve a combined control/measurement problem; (2) a technique by which it is possible to apply deterministic methods, specifically the minimum principle, to the study of stochastic problems; (3) the methods described are applied to linear systems with Gaussian disturbances to study the structure of the resulting control system; and (4) several applications are considered.

Distributed architecture and distributed processing mode in urban sewage treatment

NASA Astrophysics Data System (ADS)

Zhou, Ruipeng; Yang, Yuanming

2017-05-01

Decentralized rural sewage treatment facility over the broad area, a larger operation and management difficult, based on the analysis of rural sewage treatment model based on the response to these challenges, we describe the principle, structure and function in networking technology and network communications technology as the core of distributed remote monitoring system, through the application of case analysis to explore remote monitoring system features in a decentralized rural sewage treatment facilities in the daily operation and management. Practice shows that the remote monitoring system to provide technical support for the long-term operation and effective supervision of the facilities, and reduced operating, maintenance and supervision costs for development.

[SciELO: method for electronic publishing].

PubMed

Laerte Packer, A; Rocha Biojone, M; Antonio, I; Mayumi Takemaka, R; Pedroso García, A; Costa da Silva, A; Toshiyuki Murasaki, R; Mylek, C; Carvalho Reisl, O; Rocha F Delbucio, H C

2001-01-01

It describes the SciELO Methodology Scientific Electronic Library Online for electronic publishing of scientific periodicals, examining issues such as the transition from traditional printed publication to electronic publishing, the scientific communication process, the principles which founded the methodology development, its application in the building of the SciELO site, its modules and components, the tools use for its construction etc. The article also discusses the potentialities and trends for the area in Brazil and Latin America, pointing out questions and proposals which should be investigated and solved by the methodology. It concludes that the SciELO Methodology is an efficient, flexible and wide solution for the scientific electronic publishing.

Transforming schools into communities of thinking and learning about serious matters.

PubMed

Brown, A L

1997-04-01

In this article, a program of research known as Fostering Communities of Learners is described. This program is in place in several schools and classrooms serving inner-city students from 6 to 12 years of age. Based on theoretical advances in cognitive and developmental psychology, the program is successful at improving both literacy skills and domain-area subject matter knowledge (e.g., environmental science and biology). Building on young children's emergent strategic and metacognitive knowledge, together with their skeletal biological theories, the program leads children to discover the deep principles of the domain and to develop flexible learning and inquiry strategies of wide applicability.

Feasibility and applicability of antimicrobial stewardship in immunocompromised patients.

PubMed

Robilotti, Elizabeth; Holubar, Marisa; Seo, Susan K; Deresinski, Stan

2017-08-01

Antimicrobial stewardship is the primary intervention in the battle against antimicrobial resistance, but clinicians do not always apply many key antimicrobial stewardship principles to patients with significant immune defects due to lack of data and fear of bad outcomes. We review evidence regarding the application of stewardship principles to immunocompromised patients, with a focus on solid organ and hematopoietic stem cell transplant recipients. Antimicrobial stewardship programs (ASPs), targeting immunocompromised patient populations such as oncology and transplant, are gaining traction. Emerging literature suggests that several stewardship interventions can be adapted to immunocompromised hosts and improve antimicrobial utilization, but data supporting improved outcomes is very limited. The application of antimicrobial stewardship principles to immunocompromised patients is feasible, necessary, and urgent. As antimicrobial stewardship programs gain momentum across a diverse range of healthcare settings more immunocompromised patients will fall under their purview. It is imperative that centers applying antimicrobial stewardship principles share their experience and establish collaborative research efforts to advance our knowledge base in applying antimicrobial stewardship initiatives to immunocompromised host populations, both in terms of programmatic success and patient outcomes.

Nanomaterials-based biosensors for detection of microorganisms and microbial toxins.

PubMed

Sutarlie, Laura; Ow, Sian Yang; Su, Xiaodi

2017-04-01

Detection of microorganisms and microbial toxins is important for health and safety. Due to their unique physical and chemical properties, nanomaterials have been extensively used to develop biosensors for rapid detection of microorganisms with microbial cells and toxins as target analytes. In this paper, the design principles of nanomaterials-based biosensors for four selected analyte categories (bacteria cells, toxins, mycotoxins, and protozoa cells), closely associated with the target analytes' properties is reviewed. Five signal transducing methods that are less equipment intensive (colorimetric, fluorimetric, surface enhanced Raman scattering, electrochemical, and magnetic relaxometry methods) is described and compared for their sensory performance (in term oflimit of detection, dynamic range, and response time) for all analyte categories. In the end, the suitability of these five sensing principles for on-site or field applications is discussed. With a comprehensive coverage of nanomaterials, design principles, sensing principles, and assessment on the sensory performance and suitability for on-site application, this review offers valuable insight and perspective for designing suitable nanomaterials-based microorganism biosensors for a given application. Copyright © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Design of virus-based nanomaterials for medicine, biotechnology, and energy

PubMed Central

Wen, Amy M.; Steinmetz, Nicole F.

2016-01-01

Virus-based nanomaterials are versatile materials that naturally self-assemble and have relevance for a broad range of applications including medicine, biotechnology, and energy. This review provides an overview of recent developments in “chemical virology.” Viruses, as materials, provide unique nanoscale scaffolds that have relevance in chemical biology and nanotechnology, with diverse areas of applications. Some fundamental advantages of viruses, compared to synthetically programmed materials, include the highly precise spatial arrangement of their subunits into a diverse array of shapes and sizes and many available avenues for easy and reproducible modification. Here, we will first survey the broad distribution of viruses and various methods for producing virus-based nanoparticles, as well as engineering principles used to impart new functionalities. We will then examine the broad range of applications and implications of virus-based materials, focusing on the medical, biotechnology, and energy sectors. We anticipate that this field will continue to evolve and grow, with exciting new possibilities stemming from advancements in the rational design of virus-based nanomaterials. PMID:27152673

Evolving neural networks with genetic algorithms to study the string landscape

NASA Astrophysics Data System (ADS)

Ruehle, Fabian

2017-08-01

We study possible applications of artificial neural networks to examine the string landscape. Since the field of application is rather versatile, we propose to dynamically evolve these networks via genetic algorithms. This means that we start from basic building blocks and combine them such that the neural network performs best for the application we are interested in. We study three areas in which neural networks can be applied: to classify models according to a fixed set of (physically) appealing features, to find a concrete realization for a computation for which the precise algorithm is known in principle but very tedious to actually implement, and to predict or approximate the outcome of some involved mathematical computation which performs too inefficient to apply it, e.g. in model scans within the string landscape. We present simple examples that arise in string phenomenology for all three types of problems and discuss how they can be addressed by evolving neural networks from genetic algorithms.

Building international genomics collaboration for global health security

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cui, Helen H.; Erkkila, Tracy; Chain, Patrick S. G.

Genome science and technologies are transforming life sciences globally in many ways and becoming a highly desirable area for international collaboration to strengthen global health. The Genome Science Program at the Los Alamos National Laboratory is leveraging a long history of expertise in genomics research to assist multiple partner nations in advancing their genomics and bioinformatics capabilities. The capability development objectives focus on providing a molecular genomics-based scientific approach for pathogen detection, characterization, and biosurveillance applications. The general approaches include introduction of basic principles in genomics technologies, training on laboratory methodologies and bioinformatic analysis of resulting data, procurement, and installationmore » of next-generation sequencing instruments, establishing bioinformatics software capabilities, and exploring collaborative applications of the genomics capabilities in public health. Genome centers have been established with public health and research institutions in the Republic of Georgia, Kingdom of Jordan, Uganda, and Gabon; broader collaborations in genomics applications have also been developed with research institutions in many other countries.« less

Building international genomics collaboration for global health security

DOE PAGES

Cui, Helen H.; Erkkila, Tracy; Chain, Patrick S. G.; ...

2015-12-07

Genome science and technologies are transforming life sciences globally in many ways and becoming a highly desirable area for international collaboration to strengthen global health. The Genome Science Program at the Los Alamos National Laboratory is leveraging a long history of expertise in genomics research to assist multiple partner nations in advancing their genomics and bioinformatics capabilities. The capability development objectives focus on providing a molecular genomics-based scientific approach for pathogen detection, characterization, and biosurveillance applications. The general approaches include introduction of basic principles in genomics technologies, training on laboratory methodologies and bioinformatic analysis of resulting data, procurement, and installationmore » of next-generation sequencing instruments, establishing bioinformatics software capabilities, and exploring collaborative applications of the genomics capabilities in public health. Genome centers have been established with public health and research institutions in the Republic of Georgia, Kingdom of Jordan, Uganda, and Gabon; broader collaborations in genomics applications have also been developed with research institutions in many other countries.« less

Design and applications of a multimodality image data warehouse framework.

PubMed

Wong, Stephen T C; Hoo, Kent Soo; Knowlton, Robert C; Laxer, Kenneth D; Cao, Xinhau; Hawkins, Randall A; Dillon, William P; Arenson, Ronald L

2002-01-01

A comprehensive data warehouse framework is needed, which encompasses imaging and non-imaging information in supporting disease management and research. The authors propose such a framework, describe general design principles and system architecture, and illustrate a multimodality neuroimaging data warehouse system implemented for clinical epilepsy research. The data warehouse system is built on top of a picture archiving and communication system (PACS) environment and applies an iterative object-oriented analysis and design (OOAD) approach and recognized data interface and design standards. The implementation is based on a Java CORBA (Common Object Request Broker Architecture) and Web-based architecture that separates the graphical user interface presentation, data warehouse business services, data staging area, and backend source systems into distinct software layers. To illustrate the practicality of the data warehouse system, the authors describe two distinct biomedical applications--namely, clinical diagnostic workup of multimodality neuroimaging cases and research data analysis and decision threshold on seizure foci lateralization. The image data warehouse framework can be modified and generalized for new application domains.

THz spectroscopy: An emerging technology for pharmaceutical development and pharmaceutical Process Analytical Technology (PAT) applications

NASA Astrophysics Data System (ADS)

Wu, Huiquan; Khan, Mansoor

2012-08-01

As an emerging technology, THz spectroscopy has gained increasing attention in the pharmaceutical area during the last decade. This attention is due to the fact that (1) it provides a promising alternative approach for in-depth understanding of both intermolecular interaction among pharmaceutical molecules and pharmaceutical product quality attributes; (2) it provides a promising alternative approach for enhanced process understanding of certain pharmaceutical manufacturing processes; and (3) the FDA pharmaceutical quality initiatives, most noticeably, the Process Analytical Technology (PAT) initiative. In this work, the current status and progress made so far on using THz spectroscopy for pharmaceutical development and pharmaceutical PAT applications are reviewed. In the spirit of demonstrating the utility of first principles modeling approach for addressing model validation challenge and reducing unnecessary model validation "burden" for facilitating THz pharmaceutical PAT applications, two scientific case studies based on published THz spectroscopy measurement results are created and discussed. Furthermore, other technical challenges and opportunities associated with adapting THz spectroscopy as a pharmaceutical PAT tool are highlighted.

Advantages in functional imaging of the brain.

PubMed

Mier, Walter; Mier, Daniela

2015-01-01

As neuronal pathologies cause only minor morphological alterations, molecular imaging techniques are a prerequisite for the study of diseases of the brain. The development of molecular probes that specifically bind biochemical markers and the advances of instrumentation have revolutionized the possibilities to gain insight into the human brain organization and beyond this-visualize structure-function and brain-behavior relationships. The review describes the development and current applications of functional brain imaging techniques with a focus on applications in psychiatry. A historical overview of the development of functional imaging is followed by the portrayal of the principles and applications of positron emission tomography (PET) and functional magnetic resonance imaging (fMRI), two key molecular imaging techniques that have revolutionized the ability to image molecular processes in the brain. We conclude that the juxtaposition of PET and fMRI in hybrid PET/MRI scanners enhances the significance of both modalities for research in neurology and psychiatry and might pave the way for a new area of personalized medicine.

Principles for the formation of an effective concept of multifunctional high-rise construction investment projects

NASA Astrophysics Data System (ADS)

Beliakov, Sergei

2018-03-01

Investment projects of high-rise construction have a number of features that determine specific risks and additional opportunities that require analysis and accounting in the formation of an effective project concept. The most significant features of high-rise construction include long construction time, complexity of technical and technological solutions, complexity of decisions on the organization of construction and operation, high cost of construction and operation, complexity in determining the ratio of areas designed to accommodate different functional areas, when organizing and coordinating the operation of the facility, with internal zoning. Taking into account the specificity of high-rise construction, among the factors determining the effectiveness of projects, it is advisable to consider as key factors: organizational, technological and investment factors. Within the framework of the article, the author singled out key particular functions for each group of factors under consideration, and also developed a system of principles for the formation of an effective concept of multifunctional high-rise construction investment projects, including the principle of logistic efficiency, the principle of optimal functional zoning, the principle of efficiency of equipment use, the principle of optimizing technological processes, the principle maximization of income, the principle of fund management, the principle of risk management . The model of formation of an effective concept of investment projects of multifunctional high-rise construction developed by the author can contribute to the development of methodological tools in the field of managing the implementation of high-rise construction projects, taking into account their specificity in the current economic conditions.

Preventing Supercooling Of Gallium

NASA Technical Reports Server (NTRS)

Massucco, Arthur A.; Wenghoefer, Hans M.; Wilkins, Ronnie

1994-01-01

Principle of heterogeneous nucleation exploited to prevent gallium from supercooling, enabling its use as heat-storage material that crystallizes reproducibly at its freezing or melting temperature of 29 to 30 degrees C. In original intended application, gallium used as heat-storage material in gloves of space suits. Terrestrial application lies in preparation of freezing-temperature reference samples for laboratories. Principle of heterogeneous nucleation also exploited similarly in heat pipes filled with sodium.

The revised Canadian Guidelines for the Economic Evaluation of Pharmaceuticals.

PubMed

Glennie, J L; Torrance, G W; Baladi, J F; Berka, C; Hubbard, E; Menon, D; Otten, N; Rivière, M

1999-05-01

The first edition of the Guidelines for Economic Evaluation of Pharmaceuticals: Canada was published in November 1994. At that time, the Canadian Coordinating Office for Health Technology Assessment (CCOHTA) was assigned the task of maintaining and regularly updating the Canadian Guidelines. Since their introduction, a great deal of experience has been gained with the practical application of the guidelines. Their role has also evolved over time, from being a framework for pharmacoeconomic research to the point where a wide variety of decision-makers use economic evaluations based on the principles set out in the guidelines as a means of facilitating their formulary decisions. In addition, methodologies in certain areas (and the body of related research literature in general) have developed considerably over time. Given these changes in the science and the experience gained, CCOHTA convened a multi-disciplinary committee to address the need for revisions to the guidelines. The underlying principles of the review process were to keep the guidance nature of the document, to focus on the needs of 'doers' (so as to meet the information needs of 'users') and to provide information and advice in areas of controversy, with sound direction in areas of general agreement. The purpose of this review is three-fold: (i) to outline the process which lead to the revision of the Canadian Guidelines; (ii) to describe the major changes made to the second edition of this document; and (iii) to consider the 'next steps' as they relate to the impact of such guidelines and the measurement of outcomes related to economic assessments of pharmaceuticals in general.

41 CFR 101-27.102-3 - Limitations on use.

Code of Federal Regulations, 2010 CFR

2010-07-01

... possession, the economic purchase quantity (EPQ) principle shall be used as described in the GSA Handbook. The Economic Order Quantity Principle and Applications. [29 FR 15997, Dec. 1, 1964, as amended at 31...

26 CFR 1.941-3 - Illustration of principles.

Code of Federal Regulations, 2013 CFR

2013-04-01

... (CONTINUED) INCOME TAXES (CONTINUED) China Trade Act Corporations § 1.941-3 Illustration of principles. The application of section 941 may be illustrated by the following example: Example. (1) The A Company, a China...

26 CFR 1.941-3 - Illustration of principles.

Code of Federal Regulations, 2014 CFR

2014-04-01

... (CONTINUED) INCOME TAXES (CONTINUED) China Trade Act Corporations § 1.941-3 Illustration of principles. The application of section 941 may be illustrated by the following example: Example. (1) The A Company, a China...

26 CFR 1.941-3 - Illustration of principles.

Code of Federal Regulations, 2012 CFR

2012-04-01

... (CONTINUED) INCOME TAXES (CONTINUED) China Trade Act Corporations § 1.941-3 Illustration of principles. The application of section 941 may be illustrated by the following example: Example. (1) The A Company, a China...

26 CFR 1.941-3 - Illustration of principles.

Code of Federal Regulations, 2010 CFR

2010-04-01

... (CONTINUED) INCOME TAXES China Trade Act Corporations § 1.941-3 Illustration of principles. The application of section 941 may be illustrated by the following example: Example. (1) The A Company, a China Trade...

26 CFR 1.941-3 - Illustration of principles.

Code of Federal Regulations, 2011 CFR

2011-04-01

... (CONTINUED) INCOME TAXES (CONTINUED) China Trade Act Corporations § 1.941-3 Illustration of principles. The application of section 941 may be illustrated by the following example: Example. (1) The A Company, a China...

Implications of Accounting Practice for Financial Analysis.

ERIC Educational Resources Information Center

Wilkinson, William M.

1979-01-01

Different kinds of financial data are needed by different levels of management and in different areas of support. Accounting principles for nonprofit organizations need to be determined. Accrual accounting principles, fund accounting, restricted and unrestricted funds, etc., are described. (MLW)

Full and Open Access to Data in the Global Earth Observing System of Systems (GEOSS): Implementing the GEOSS Data Sharing Principles

NASA Astrophysics Data System (ADS)

Chen, R. S.; Uhlir, P. F.; Gabrinowicz, J. I.

2008-12-01

Full and open access to data from remote sensing platforms and other sources can facilitate not only scientific research but also the more widespread and effective use of scientific data for the benefit of society. The Global Earth Observing System of Systems (GEOSS) is a major international initiative of the Group on Earth Observations (GEO) to develop "coordinated, comprehensive and sustained Earth observations and information." In 2005, GEO adopted the GEOSS Data Sharing Principles, which call for the "full and open exchange of data, metadata, and products shared within GEOSS, recognizing relevant international instruments and national policies and legislation." These Principles also note that "All shared data, metadata, and products will be made available with minimum time delay and at minimum cost" and that "All shared data, metadata, and products being free of charge or no more than cost of reproduction will be encouraged for research and education." GEOSS Task DA-06-01, aimed at developing a set of recommended implementation guidelines for the Principles, was established in 2006 under the leadership of CODATA, the Committee on Data for Science and Technology of the International Council for Science (ICSU). An international team of authors has developed a draft White Paper on the GEOSS Data Sharing Principles and a proposed set of implementation guidelines. These have been carefully reviewed by independent reviewers, various GEO Committees, and GEO National Members and Participating Organizations. It is expected that the proposed implementation guidelines will be discussed at the GEO-V Plenary in Budapest in November 2008. The current version of the proposed implementation guidelines recognizes the importance of good faith, voluntary adherence to the Principles by GEO National Members and Participating Organizations. It underscores the value of reuse and re-dissemination of GEOSS data with minimum restrictions, not only within GEOSS itself but on the part of GEOSS users. Consistency with relevant international instruments and applicable policies and legislation is essential, and therefore clarification and coordination of applicable policies and procedures are needed. Pricing of GEOSS data, metadata, and products should be based on the premise that the data and information within GEOSS is a public good for public-interest use in the nine societal benefit areas. Time delays for data access from both operational and research systems should be kept to a minimum, reflecting the norms of the relevant scientific communities or data processing centers. The proposed guidelines also emphasize the need to better define research and education uses and to develop and collect usage metrics and indicators. The draft White Paper provides a more detailed review of past and current data policies related to space-based and spatial data, assesses the implications of the Data Sharing Principles for selected case studies, and discusses a number of other important implementation issues. Successful implementation of the GEOSS Data Sharing Principles is likely to be a critical element in the future effectiveness and value of GEOSS.

Coupled fluid-structure interaction. Part 1: Theory. Part 2: Application

NASA Technical Reports Server (NTRS)

Felippa, Carlos A.; Ohayon, Roger

1991-01-01

A general three dimensional variational principle is obtained for the motion of an acoustic field enclosed in a rigid or flexible container by the method of canonical decomposition applied to a modified form of the wave equation in the displacement potential. The general principle is specialized to a mixed two-field principle that contains the fluid displacement potential and pressure as independent fields. Semidiscrete finite element equations of motion based on this principle are derived and sample cases are given.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Greitzer, Frank L.; Kuchar, Olga A.; Huston, Kristy A.

Serious games use entertainment principles, creativity, and technology to meet government or corporate training objectives, but these principles alone will not guarantee that the intended learning will occur. To be effective, serious games must incorporate sound cognitive, learning, and pedagogical principles into their design and structure. In this paper, we review cognitive principles that can be applied to improve the training effectiveness in serious games and we describe a process we used to design improvements for an existing game-based training application in the domain of cyber security education.