Science.gov

Sample records for principles applications state

  1. Thermographic Phosphors for High Temperature Measurements: Principles, Current State of the Art and Recent Applications

    PubMed Central

    Khalid, Ashiq Hussain; Kontis, Konstantinos

    2008-01-01

    This paper reviews the state of phosphor thermometry, focusing on developments in the past 15 years. The fundamental principles and theory are presented, and the various spectral and temporal modes, including the lifetime decay, rise time and intensity ratio, are discussed. The entire phosphor measurement system, including relative advantages to conventional methods, choice of phosphors, bonding techniques, excitation sources and emission detection, is reviewed. Special attention is given to issues that may arise at high temperatures. A number of recent developments and applications are surveyed, with examples including: measurements in engines, hypersonic wind tunnel experiments, pyrolysis studies and droplet/spray/gas temperature determination. They show the technique is flexible and successful in measuring temperatures where conventional methods may prove to be unsuitable. PMID:27873836

  2. First-principles equation-of-state table of deuterium for inertial confinement fusion applications

    SciTech Connect

    Hu, S. X.; Goncharov, V. N.; Skupsky, S.; Militzer, B.

    2011-12-01

    Understanding and designing inertial confinement fusion (ICF) implosions through radiation-hydrodynamics simulations relies on the accurate knowledge of the equation of state (EOS) of the deuterium and tritium fuels. To minimize the drive energy for ignition, the imploding shell of DT fuel must be kept as cold as possible. Such low-adiabat ICF implosions can access to coupled and degenerate plasma conditions, in which the analytical EOS models become inaccurate due to many-body effects. Using the path-integral Monte Carlo (PIMC) simulations we have derived a first-principles EOS (FPEOS) table of deuterium that covers typical ICF fuel conditions at densities ranging from 0.002 to 1596 g/cm{sup 3} and temperatures of 1.35 eV to 5.5 keV. We report the internal energy and the pressure and discuss the structure of the plasma in terms of pair-correlation functions. When compared with the widely used SESAME table and the revised Kerley03 table, discrepancies in the internal energy and in the pressure are identified for moderately coupled and degenerate plasma conditions. In contrast to the SESAME table, the revised Kerley03 table is in better agreement with our FPEOS results over a wide range of densities and temperatures. Although subtle differences still exist for lower temperatures (T < 10 eV) and moderate densities (1 to 10 g/cm{sup 3}), hydrodynamics simulations of cryogenic ICF implosions using the FPEOS table and the Kerley03 table have resulted in similar results for the peak density, areal density ({rho}R), and neutron yield, which differ significantly from the SESAME simulations.

  3. First-principles equation-of-state table of deuterium for inertial confinement fusion applications

    NASA Astrophysics Data System (ADS)

    Hu, S. X.; Militzer, B.; Goncharov, V. N.; Skupsky, S.

    2011-12-01

    Understanding and designing inertial confinement fusion (ICF) implosions through radiation-hydrodynamics simulations relies on the accurate knowledge of the equation of state (EOS) of the deuterium and tritium fuels. To minimize the drive energy for ignition, the imploding shell of DT fuel must be kept as cold as possible. Such low-adiabat ICF implosions can access to coupled and degenerate plasma conditions, in which the analytical EOS models become inaccurate due to many-body effects. Using the path-integral Monte Carlo (PIMC) simulations we have derived a first-principles EOS (FPEOS) table of deuterium that covers typical ICF fuel conditions at densities ranging from 0.002 to 1596 g/cm3 and temperatures of 1.35 eV to 5.5 keV. We report the internal energy and the pressure and discuss the structure of the plasma in terms of pair-correlation functions. When compared with the widely used SESAME table and the revised Kerley03 table, discrepancies in the internal energy and in the pressure are identified for moderately coupled and degenerate plasma conditions. In contrast to the SESAME table, the revised Kerley03 table is in better agreement with our FPEOS results over a wide range of densities and temperatures. Although subtle differences still exist for lower temperatures (T < 10 eV) and moderate densities (1 to 10 g/cm3), hydrodynamics simulations of cryogenic ICF implosions using the FPEOS table and the Kerley03 table have resulted in similar results for the peak density, areal density (ρR), and neutron yield, which differ significantly from the SESAME simulations.

  4. Microdosimetry: Principles and applications

    PubMed Central

    Santa Cruz, Gustavo A.

    2016-01-01

    Aim to present the most important aspects of Microdosimetry, a research field in radiation biophysics. Background microdosimetry is the branch of radiation biophysics that systematically studies the spatial, temporal and spectral aspects of the stochastic nature of the energy deposition processes in microscopic structures. Materials and Methods we briefly review its history, the people, the formalism and the theories and devices that allowed researchers to begin to understand the true nature of radiation action on living matter. Results and Conclusions we outline some of its applications, especially to Boron Neutron Capture Therapy, attempting to explain the biological effectiveness of the boron thermal neutron capture reaction. PMID:26933397

  5. Nanotechnology: Principles and Applications

    NASA Astrophysics Data System (ADS)

    Logothetidis, S.

    Nanotechnology is one of the leading scientific fields today since it combines knowledge from the fields of Physics, Chemistry, Biology, Medicine, Informatics, and Engineering. It is an emerging technological field with great potential to lead in great breakthroughs that can be applied in real life. Novel nano- and biomaterials, and nanodevices are fabricated and controlled by nanotechnology tools and techniques, which investigate and tune the properties, responses, and functions of living and non-living matter, at sizes below 100 nm. The application and use of nanomaterials in electronic and mechanical devices, in optical and magnetic components, quantum computing, tissue engineering, and other biotechnologies, with smallest features, widths well below 100 nm, are the economically most important parts of the nanotechnology nowadays and presumably in the near future. The number of nanoproducts is rapidly growing since more and more nanoengineered materials are reaching the global market The continuous revolution in nanotechnology will result in the fabrication of nanomaterials with properties and functionalities which are going to have positive changes in the lives of our citizens, be it in health, environment, electronics or any other field. In the energy generation challenge where the conventional fuel resources cannot remain the dominant energy source, taking into account the increasing consumption demand and the CO2 emissions alternative renewable energy sources based on new technologies have to be promoted. Innovative solar cell technologies that utilize nanostructured materials and composite systems such as organic photovoltaics offer great technological potential due to their attractive properties such as the potential of large-scale and low-cost roll-to-roll manufacturing processes The advances in nanomaterials necessitate parallel progress of the nanometrology tools and techniques to characterize and manipulate nanostructures. Revolutionary new approaches

  6. Artificial intelligence: Principles and applications

    SciTech Connect

    Yazdami, M.

    1985-01-01

    The book covers the principles of AI, the main areas of application, as well as considering some of the social implications. The applications chapters have a common format structured as follows: definition of the topic; approach with conventional computing techniques; why 'intelligence' would provide a better approach; and how AI techniques would be used and the limitations. The contents discussed are: Principles of artificial intelligence; AI programming environments; LISP, list processing and pattern-making; AI programming with POP-11; Computer processing of natural language; Speech synthesis and recognition; Computer vision; Artificial intelligence and robotics; The anatomy of expert systems - Forsyth; Machine learning; Memory models of man and machine; Artificial intelligence and cognitive psychology; Breaking out of the chinese room; Social implications of artificial intelligence; and Index.

  7. Enzymes: principles and biotechnological applications.

    PubMed

    Robinson, Peter K

    2015-01-01

    Enzymes are biological catalysts (also known as biocatalysts) that speed up biochemical reactions in living organisms, and which can be extracted from cells and then used to catalyse a wide range of commercially important processes. This chapter covers the basic principles of enzymology, such as classification, structure, kinetics and inhibition, and also provides an overview of industrial applications. In addition, techniques for the purification of enzymes are discussed.

  8. Enzymes: principles and biotechnological applications

    PubMed Central

    Robinson, Peter K.

    2015-01-01

    Enzymes are biological catalysts (also known as biocatalysts) that speed up biochemical reactions in living organisms, and which can be extracted from cells and then used to catalyse a wide range of commercially important processes. This chapter covers the basic principles of enzymology, such as classification, structure, kinetics and inhibition, and also provides an overview of industrial applications. In addition, techniques for the purification of enzymes are discussed. PMID:26504249

  9. Updated Principle of Corresponding States

    ERIC Educational Resources Information Center

    Ben-Amotz, Dor; Gift, Alan D.; Levine, R. D.

    2004-01-01

    The rule of corresponding states, which shows the connection between the thermodynamic properties of various liquids is re-examined. The overall likeness is observed by using an updated scaling technique of Lennard-Jones corresponding states (LJ-CS).

  10. Studying Dynamics by Magic-Angle Spinning Solid-State NMR Spectroscopy: Principles and Applications to Biomolecules

    PubMed Central

    Schanda, Paul; Ernst, Matthias

    2016-01-01

    Magic-angle spinning solid-state NMR spectroscopy is an important technique to study molecular structure, dynamics and interactions, and is rapidly gaining importance in biomolecular sciences. Here we provide an overview of experimental approaches to study molecular dynamics by MAS solid-state NMR, with an emphasis on the underlying theoretical concepts and differences of MAS solid-state NMR compared to solution-state NMR. The theoretical foundations of nuclear spin relaxation are revisited, focusing on the particularities of spin relaxation in solid samples under magic-angle spinning. We discuss the range of validity of Redfield theory, as well as the inherent multi-exponential behavior of relaxation in solids. Experimental challenges for measuring relaxation parameters in MAS solid-state NMR and a few recently proposed relaxation approaches are discussed, which provide information about time scales and amplitudes of motions ranging from picoseconds to milliseconds. We also discuss the theoretical basis and experimental measurements of anisotropic interactions (chemical-shift anisotropies, dipolar and quadrupolar couplings), which give direct information about the amplitude of motions. The potential of combining relaxation data with such measurements of dynamically-averaged anisotropic interactions is discussed. Although the focus of this review is on the theoretical foundations of dynamics studies rather than their application, we close by discussing a small number of recent dynamics studies, where the dynamic properties of proteins in crystals are compared to those in solution. PMID:27110043

  11. Artificial intelligence: Principles and applications

    SciTech Connect

    Yazdani, M.

    1986-01-01

    Following the Japanese announcement that they intend to devise, make, and market, in the 1990s, computers incorporating a level of intelligence, a vast amount of energy and expense has been diverted at the field of Artificial Intelligence. Workers for the past 25 years in this discipline have tried to reproduce human behavior on computers and this book presents their achievements and the problems. Subjects include: computer vision, speech processing, robotics, natural language processing expert systems and machine learning. The book also attempts to show the general principles behind the various applications and finally attempts to show their implications for other human endeavors such as philosophy, psychology, and the development of modern society.

  12. First-principles studies on the equation of state, thermal conductivity, and opacity of deuterium-tritium (DT) and polystyrene (CH) for inertial confinement fusion applications

    NASA Astrophysics Data System (ADS)

    Hu, S. X.; Collins, L. A.; Goncharov, V. N.; Kress, J. D.; Boehly, T. R.; Epstein, R.; McCrory, R. L.; Skupsky, S.

    2016-05-01

    Using first-principles (FP) methods, we have performed ab initio compute for the equation of state (EOS), thermal conductivity, and opacity of deuterium-tritium (DT) in a wide range of densities and temperatures for inertial confinement fusion (ICF) applications. These systematic investigations have recently been expanded to accurately compute the plasma properties of CH ablators under extreme conditions. In particular, the first-principles EOS and thermal-conductivity tables of CH are self-consistently built from such FP calculations, which are benchmarked by experimental measurements. When compared with the traditional models used for these plasma properties in hydrocodes, significant differences have been identified in the warm dense plasma regime. When these FP-calculated properties of DT and CH were used in our hydrodynamic simulations of ICF implosions, we found that the target performance in terms of neutron yield and energy gain can vary by a factor of 2 to 3, relative to traditional model simulations.

  13. First-principles studies on the equation-of-state, thermal-conductivity, and opacity of deuterium-tritium and polystyrene (CH) for inertial confinement fusion applications

    SciTech Connect

    Hu, Suxing; Collins, Lee A.; Goncharov, V. N.; Kress, Joel David; Boehly, T. R.; Epstein, R.; McCrory, R. L.; Skupsky, S.

    2016-05-26

    Using first-principles (FP) methods, we have performed ab initio compute for the equation of state (EOS), thermal conductivity, and opacity of deuterium-tritium (DT) in a wide range of densities and temperatures for inertial confinement fusion (ICF) applications. These systematic investigations have recently been expanded to accurately compute the plasma properties of CH ablators under extreme conditions. In particular, the first-principles EOS and thermal-conductivity tables of CH are self-consistently built from such FP calculations, which are benchmarked by experimental measurements. When compared with the traditional models used for these plasma properties in hydrocodes, significant differences have been identified in the warm dense plasma regime. When these FP-calculated properties of DT and CH were used in our hydrodynamic simulations of ICF implosions, we found that the target performance in terms of neutron yield and energy gain can vary by a factor of 2 to 3, relative to traditional model simulations.

  14. Scattered Radiation Emission Imaging: Principles and Applications

    PubMed Central

    Nguyen, M. K.; Truong, T. T.; Morvidone, M.; Zaidi, H.

    2011-01-01

    Imaging processes built on the Compton scattering effect have been under continuing investigation since it was first suggested in the 50s. However, despite many innovative contributions, there are still formidable theoretical and technical challenges to overcome. In this paper, we review the state-of-the-art principles of the so-called scattered radiation emission imaging. Basically, it consists of using the cleverly collected scattered radiation from a radiating object to reconstruct its inner structure. Image formation is based on the mathematical concept of compounded conical projection. It entails a Radon transform defined on circular cone surfaces in order to express the scattered radiation flux density on a detecting pixel. We discuss in particular invertible cases of such conical Radon transforms which form a mathematical basis for image reconstruction methods. Numerical simulations performed in two and three space dimensions speak in favor of the viability of this imaging principle and its potential applications in various fields. PMID:21747823

  15. Application of the principle of similarity fluid mechanics

    NASA Technical Reports Server (NTRS)

    Hendricks, R. C.; Sengers, J. V.

    1979-01-01

    Possible applications of the principle of similarity to fluid mechanics is described and illustrated. In correlating thermophysical properties of fluids, the similarity principle transcends the traditional corresponding states principle. In fluid mechanics the similarity principle is useful in correlating flow processes that can be modeled adequately with one independent variable (i.e., one-dimensional flows). In this paper we explore the concept of transforming the conservation equations by combining similarity principles for thermophysical properties with those for fluid flow. We illustrate the usefulness of the procedure by applying such a transformation to calculate two phase critical mass flow through a nozzle.

  16. First-principles studies on the equation-of-state, thermal-conductivity, and opacity of deuterium-tritium and polystyrene (CH) for inertial confinement fusion applications

    DOE PAGES

    Hu, Suxing; Collins, Lee A.; Goncharov, V. N.; ...

    2016-05-26

    Using first-principles (FP) methods, we have performed ab initio compute for the equation of state (EOS), thermal conductivity, and opacity of deuterium-tritium (DT) in a wide range of densities and temperatures for inertial confinement fusion (ICF) applications. These systematic investigations have recently been expanded to accurately compute the plasma properties of CH ablators under extreme conditions. In particular, the first-principles EOS and thermal-conductivity tables of CH are self-consistently built from such FP calculations, which are benchmarked by experimental measurements. When compared with the traditional models used for these plasma properties in hydrocodes, significant differences have been identified in the warmmore » dense plasma regime. When these FP-calculated properties of DT and CH were used in our hydrodynamic simulations of ICF implosions, we found that the target performance in terms of neutron yield and energy gain can vary by a factor of 2 to 3, relative to traditional model simulations.« less

  17. Deriving and applying generally applicable safety principles

    SciTech Connect

    Spray, S.D.

    1998-08-01

    The nuclear detonation safety of modern nuclear weapons depends on a coordinated safety theme incorporating three general safety principles: isolation, inoperability, and incompatibility. The success of this approach has encouraged them to study whether these and/or other principles might be useful in other applications. Not surprisingly, no additional first-principles (based on physical laws) have been identified. However, a more widely applicable definition and application of the principle-based approach has been developed, resulting in a selection of strategies that are basically subsets and varied combinations of the more general principles above. However, identification of principles to be relied on is only one step in providing a safe design. As one other important example, coordinating overall architecture and strategy is essential: the authors term this a safety theme.

  18. Combining insights from solid-state NMR and first principles calculation: applications to the 19F NMR of octafluoronaphthalene.

    PubMed

    Robbins, Andrew J; Ng, William T K; Jochym, Dominik; Keal, Thomas W; Clark, Stewart J; Tozer, David J; Hodgkinson, Paul

    2007-05-21

    Advances in solid-state NMR methodology and computational chemistry are applied to the (19)F NMR of solid octafluoronaphthalene. It is demonstrated experimentally, and confirmed by density functional theory (DFT) calculations, that the spectral resolution in the magic-angle spinning spectrum is limited by the anisotropy of the bulk magnetic susceptibility (ABMS). This leads to the unusual observation that the resolution improves as the sample is diluted. DFT calculations provide assignments of each of the peaks in the (19)F spectrum, but the predictions are close to the limits of accuracy and correlation information from 2-D NMR is invaluable in confirming the assignments. The effects of non-Gaussian lineshapes on the use of 2-D NMR for mapping correlations of spectral frequencies (e.g. due to the ABMS) are also discussed.

  19. Functional Neuroimaging: Fundamental Principles and Clinical Applications.

    PubMed

    Khanna, Nishanth; Altmeyer, Wilson; Zhuo, Jiachen; Steven, Andrew

    2015-04-01

    Functional imaging modalities, such as functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI), are rapidly changing the scope and practice of neuroradiology. While these modalities have long been used in research, they are increasingly being used in clinical practice to enable reliable identification of eloquent cortex and white matter tracts in order to guide treatment planning and to serve as a diagnostic supplement when traditional imaging fails. An understanding of the scientific principles underlying fMRI and DTI is necessary in current radiological practice. fMRI relies on a compensatory hemodynamic response seen in cortical activation and the intrinsic discrepant magnetic properties of deoxy- and oxyhemoglobin. Neuronal activity can be indirectly visualized based on a hemodynamic response, termed neurovascular coupling. fMRI demonstrates utility in identifying areas of cortical activation (i.e., task-based activation) and in discerning areas of neuronal connectivity when used during the resting state, termed resting state fMRI. While fMRI is limited to visualization of gray matter, DTI permits visualization of white matter tracts through diffusion restriction along different axes. We will discuss the physical, statistical and physiological principles underlying these functional imaging modalities and explore new promising clinical applications.

  20. Principles and applications of SPATE - An update

    NASA Astrophysics Data System (ADS)

    Oliver, D. E.

    The historic background of the stress-pattern-analysis-from-thermal-emissions (SPATE) technique and its principles are reviewed, and applications related to automotive, agricultural, jet-engine, and aerospace industries are outlined. Separation of principal stresses, elevated-temperature and residual-stress measurements, and the development of theories for thermographic damage mechanisms are also discussed as research applications of the method.

  1. Teaching General Principles and Applications of Dendrogeomorphology.

    ERIC Educational Resources Information Center

    Butler, David R.

    1987-01-01

    Tree-ring analysis in geomorphology can be incorporated into a number of undergraduate methods in order to reconstruct the history of a variety of geomorphic processes. Discusses dendrochronology, general principles of dendrogeomorphology, field sampling methods, laboratory techniques, and examples of applications. (TW)

  2. Optical coherence tomography - principles and applications

    NASA Astrophysics Data System (ADS)

    Fercher, A. F.; Drexler, W.; Hitzenberger, C. K.; Lasser, T.

    2003-02-01

    There have been three basic approaches to optical tomography since the early 1980s: diffraction tomography, diffuse optical tomography and optical coherence tomography (OCT). Optical techniques are of particular importance in the medical field, because these techniques promise to be safe and cheap and, in addition, offer a therapeutic potential. Advances in OCT technology have made it possible to apply OCT in a wide variety of applications but medical applications are still dominating. Specific advantages of OCT are its high depth and transversal resolution, the fact, that its depth resolution is decoupled from transverse resolution, high probing depth in scattering media, contact-free and non-invasive operation, and the possibility to create various function dependent image contrasting methods. This report presents the principles of OCT and the state of important OCT applications. OCT synthesises cross-sectional images from a series of laterally adjacent depth-scans. At present OCT is used in three different fields of optical imaging, in macroscopic imaging of structures which can be seen by the naked eye or using weak magnifications, in microscopic imaging using magnifications up to the classical limit of microscopic resolution and in endoscopic imaging, using low and medium magnification. First, OCT techniques, like the reflectometry technique and the dual beam technique were based on time-domain low coherence interferometry depth-scans. Later, Fourier-domain techniques have been developed and led to new imaging schemes. Recently developed parallel OCT schemes eliminate the need for lateral scanning and, therefore, dramatically increase the imaging rate. These schemes use CCD cameras and CMOS detector arrays as photodetectors. Video-rate three-dimensional OCT pictures have been obtained. Modifying interference microscopy techniques has led to high-resolution optical coherence microscopy that achieved sub-micrometre resolution. This report is concluded with a

  3. Ultrasound elastography: principles, techniques, and clinical applications.

    PubMed

    Dewall, Ryan J

    2013-01-01

    Ultrasound elastography is an emerging set of imaging modalities used to image tissue elasticity and are often referred to as virtual palpation. These techniques have proven effective in detecting and assessing many different pathologies, because tissue mechanical changes often correlate with tissue pathological changes. This article reviews the principles of ultrasound elastography, many of the ultrasound-based techniques, and popular clinical applications. Originally, elastography was a technique that imaged tissue strain by comparing pre- and postcompression ultrasound images. However, new techniques have been developed that use different excitation methods such as external vibration or acoustic radiation force. Some techniques track transient phenomena such as shear waves to quantitatively measure tissue elasticity. Clinical use of elastography is increasing, with applications including lesion detection and classification, fibrosis staging, treatment monitoring, vascular imaging, and musculoskeletal applications.

  4. Nuclear magnetic resonance in environmental engineering: principles and applications.

    PubMed

    Lens, P N; Hemminga, M A

    1998-01-01

    This paper gives an introduction to nuclear magnetic resonance spectroscopy (NMR) and magnetic resonance imaging (MRI) in relation to applications in the field of environmental science and engineering. The underlying principles of high resolution solution and solid state NMR, relaxation time measurements and imaging are presented. Then, the use of NMR is illustrated and reviewed in studies of biodegradation and biotransformation of soluble and solid organic matter, removal of nutrients and xenobiotics, fate of heavy metal ions, and transport processes in bioreactor systems.

  5. The applicability of the HSAB principle

    NASA Astrophysics Data System (ADS)

    Torrent-Sucarrat, Miquel

    2012-12-01

    In a very recent article (Chem. Eur. J. 14, 8652-8660 (2008)), the present author has shown that the picture of the local softness and local hardness is incomplete and that the understanding of these reactivity indices must be "redefined". In fact, the local softness and hardness contain the "same potential" information and they have to be considered as "local abundance" or "concentration" of their corresponding properties. In this contribution, we will analyze the implications in the applicability of the local version of the HSAB principle.

  6. Microwave thermography: principles, methods and clinical applications.

    PubMed

    Myers, P C; Sadowsky, N L; Barrett, A H

    1979-06-01

    We review the physical principles, method of operation, measurement limitations, and potential medical applications of microwave thermography. We present detailed results of a study of breast cancer detection at 1.3 and 3.3 GHz, including the dependence of detection rates on microwave frequency, time, tumor depth, and tumor size. At 1.3 GHz, microwave thermography detects breast cancer as well as infrared thermography (true-positive rate = 0.76 when true-negative rate = 0.63). When the two methods are combined, the true-positive rate increases by about 0.1 over that of either method alone.

  7. Generalized uncertainty principle: Approaches and applications

    NASA Astrophysics Data System (ADS)

    Tawfik, A.; Diab, A.

    2014-11-01

    In this paper, we review some highlights from the String theory, the black hole physics and the doubly special relativity and some thought experiments which were suggested to probe the shortest distances and/or maximum momentum at the Planck scale. Furthermore, all models developed in order to implement the minimal length scale and/or the maximum momentum in different physical systems are analyzed and compared. They entered the literature as the generalized uncertainty principle (GUP) assuming modified dispersion relation, and therefore are allowed for a wide range of applications in estimating, for example, the inflationary parameters, Lorentz invariance violation, black hole thermodynamics, Saleker-Wigner inequalities, entropic nature of gravitational laws, Friedmann equations, minimal time measurement and thermodynamics of the high-energy collisions. One of the higher-order GUP approaches gives predictions for the minimal length uncertainty. A second one predicts a maximum momentum and a minimal length uncertainty, simultaneously. An extensive comparison between the different GUP approaches is summarized. We also discuss the GUP impacts on the equivalence principles including the universality of the gravitational redshift and the free fall and law of reciprocal action and on the kinetic energy of composite system. The existence of a minimal length and a maximum momentum accuracy is preferred by various physical observations. The concern about the compatibility with the equivalence principles, the universality of gravitational redshift and the free fall and law of reciprocal action should be addressed. We conclude that the value of the GUP parameters remain a puzzle to be verified.

  8. A correspondence principle for steady-state wave problems

    NASA Technical Reports Server (NTRS)

    Schmerr, L. W.

    1976-01-01

    A correspondence principle was developed for treating the steady state propagation of waves from sources moving along a plane surface or interface. This new principle allows one to obtain, in a unified manner, explicit solutions for any source velocity. To illustrate the correspondence principle in a particular case, the problem of a load moving at an arbitrary constant velocity along the surface of an elastic half-space is considered.

  9. Principles, Techniques, and Applications of Tissue Microfluidics

    NASA Technical Reports Server (NTRS)

    Wade, Lawrence A.; Kartalov, Emil P.; Shibata, Darryl; Taylor, Clive

    2011-01-01

    The principle of tissue microfluidics and its resultant techniques has been applied to cell analysis. Building microfluidics to suit a particular tissue sample would allow the rapid, reliable, inexpensive, highly parallelized, selective extraction of chosen regions of tissue for purposes of further biochemical analysis. Furthermore, the applicability of the techniques ranges beyond the described pathology application. For example, they would also allow the posing and successful answering of new sets of questions in many areas of fundamental research. The proposed integration of microfluidic techniques and tissue slice samples is called tissue microfluidics because it molds the microfluidic architectures in accordance with each particular structure of each specific tissue sample. Thus, microfluidics can be built around the tissues, following the tissue structure, or alternatively, the microfluidics can be adapted to the specific geometry of particular tissues. By contrast, the traditional approach is that microfluidic devices are structured in accordance with engineering considerations, while the biological components in applied devices are forced to comply with these engineering presets. The proposed principles represent a paradigm shift in microfluidic technology in three important ways: Microfluidic devices are to be directly integrated with, onto, or around tissue samples, in contrast to the conventional method of off-chip sample extraction followed by sample insertion in microfluidic devices. Architectural and operational principles of microfluidic devices are to be subordinated to suit specific tissue structure and needs, in contrast to the conventional method of building devices according to fluidic function alone and without regard to tissue structure. Sample acquisition from tissue is to be performed on-chip and is to be integrated with the diagnostic measurement within the same device, in contrast to the conventional method of off-chip sample prep and

  10. Flow cytometry: basic principles and applications.

    PubMed

    Adan, Aysun; Alizada, Günel; Kiraz, Yağmur; Baran, Yusuf; Nalbant, Ayten

    2017-03-01

    Flow cytometry is a sophisticated instrument measuring multiple physical characteristics of a single cell such as size and granularity simultaneously as the cell flows in suspension through a measuring device. Its working depends on the light scattering features of the cells under investigation, which may be derived from dyes or monoclonal antibodies targeting either extracellular molecules located on the surface or intracellular molecules inside the cell. This approach makes flow cytometry a powerful tool for detailed analysis of complex populations in a short period of time. This review covers the general principles and selected applications of flow cytometry such as immunophenotyping of peripheral blood cells, analysis of apoptosis and detection of cytokines. Additionally, this report provides a basic understanding of flow cytometry technology essential for all users as well as the methods used to analyze and interpret the data. Moreover, recent progresses in flow cytometry have been discussed in order to give an opinion about the future importance of this technology.

  11. MEMS temperature scanner: principles, advances, and applications

    NASA Astrophysics Data System (ADS)

    Otto, Thomas; Saupe, Ray; Stock, Volker; Gessner, Thomas

    2010-02-01

    Contactless measurement of temperatures has gained enormous significance in many application fields, ranging from climate protection over quality control to object recognition in public places or military objects. Thereby measurement of linear or spatially temperature distribution is often necessary. For this purposes mostly thermographic cameras or motor driven temperature scanners are used today. Both are relatively expensive and the motor drive devices are limited regarding to the scanning rate additionally. An economic alternative are temperature scanner devices based on micro mirrors. The micro mirror, attached in a simple optical setup, reflects the emitted radiation from the observed heat onto an adapted detector. A line scan of the target object is obtained by periodic deflection of the micro scanner. Planar temperature distribution will be achieved by perpendicularly moving the target object or the scanner device. Using Planck radiation law the temperature of the object is calculated. The device can be adapted to different temperature ranges and resolution by using different detectors - cooled or uncooled - and parameterized scanner parameters. With the basic configuration 40 spatially distributed measuring points can be determined with temperatures in a range from 350°C - 1000°C. The achieved miniaturization of such scanners permits the employment in complex plants with high building density or in direct proximity to the measuring point. The price advantage enables a lot of applications, especially new application in the low-price market segment This paper shows principle, setup and application of a temperature measurement system based on micro scanners working in the near infrared range. Packaging issues and measurement results will be discussed as well.

  12. Principles, Techniques, and Applications of Tissue Microfluidics

    NASA Technical Reports Server (NTRS)

    Wade, Lawrence A.; Kartalov, Emil P.; Shibata, Darryl; Taylor, Clive

    2011-01-01

    The principle of tissue microfluidics and its resultant techniques has been applied to cell analysis. Building microfluidics to suit a particular tissue sample would allow the rapid, reliable, inexpensive, highly parallelized, selective extraction of chosen regions of tissue for purposes of further biochemical analysis. Furthermore, the applicability of the techniques ranges beyond the described pathology application. For example, they would also allow the posing and successful answering of new sets of questions in many areas of fundamental research. The proposed integration of microfluidic techniques and tissue slice samples is called "tissue microfluidics" because it molds the microfluidic architectures in accordance with each particular structure of each specific tissue sample. Thus, microfluidics can be built around the tissues, following the tissue structure, or alternatively, the microfluidics can be adapted to the specific geometry of particular tissues. By contrast, the traditional approach is that microfluidic devices are structured in accordance with engineering considerations, while the biological components in applied devices are forced to comply with these engineering presets.

  13. 32 CFR 11.4 - Applicable principles of law.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Applicable principles of law. 11.4 Section 11.4... ELEMENTS FOR TRIALS BY MILITARY COMMISSION § 11.4 Applicable principles of law. (a) General intent. All... wrongful if it is done without justification or excuse cognizable under applicable law. The element...

  14. 32 CFR 11.4 - Applicable principles of law.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Applicable principles of law. 11.4 Section 11.4... ELEMENTS FOR TRIALS BY MILITARY COMMISSION § 11.4 Applicable principles of law. (a) General intent. All... wrongful if it is done without justification or excuse cognizable under applicable law. The element...

  15. Hooke's Law: Applications of a Recurring Principle

    ERIC Educational Resources Information Center

    Giuliodori, Mauricio J.; Lujan, Heidi L.; Briggs, Whitney S.; Palani, Gurunanthan; DiCarlo, Stephen E.

    2009-01-01

    Students generally approach topics in physiology as a series of unrelated phenomena that share few underlying principles. However, if students recognized that the same underlying principles can be used to explain many physiological phenomena, they may gain a more unified understanding of physiological systems. To address this concern, we…

  16. “Stringy” coherent states inspired by generalized uncertainty principle

    NASA Astrophysics Data System (ADS)

    Ghosh, Subir; Roy, Pinaki

    2012-05-01

    Coherent States with Fractional Revival property, that explicitly satisfy the Generalized Uncertainty Principle (GUP), have been constructed in the context of Generalized Harmonic Oscillator. The existence of such states is essential in motivating the GUP based phenomenological results present in the literature which otherwise would be of purely academic interest. The effective phase space is Non-Canonical (or Non-Commutative in popular terminology). Our results have a smooth commutative limit, equivalent to Heisenberg Uncertainty Principle. The Fractional Revival time analysis yields an independent bound on the GUP parameter. Using this and similar bounds obtained here, we derive the largest possible value of the (GUP induced) minimum length scale. Mandel parameter analysis shows that the statistics is Sub-Poissonian. Correspondence Principle is deformed in an interesting way. Our computational scheme is very simple as it requires only first order corrected energy values and undeformed basis states.

  17. Fluorescence interferometry: principles and applications in biology.

    PubMed

    Bilenca, Alberto; Cao, Jing; Colice, Max; Ozcan, Aydogan; Bouma, Brett; Raftery, Laurel; Tearney, Guillermo

    2008-01-01

    The use of fluorescence radiation is of fundamental importance for tackling measurement problems in the life sciences, with recent demonstrations of probing biological systems at the nanoscale. Usually, fluorescent light-based tools and techniques use the intensity of light waves, which is easily measured by detectors. However, the phase of a fluorescence wave contains subtle, but no less important, information about the wave; yet, it has been largely unexplored. Here, we introduce the concept of fluorescence interferometry to allow the measurement of phase information of fluorescent light waves. In principle, fluorescence interferometry can be considered a unique form of optical low-coherence interferometry that uses fluorophores as a light source of low temporal coherence. Fluorescence interferometry opens up new avenues for developing new fluorescent light-based imaging, sensing, ranging, and profiling methods that to some extent resemble interferometric techniques based on white light sources. We propose two experimental realizations of fluorescence interferometry that detect the interference pattern cast by the fluorescence fields. This article discusses their measurement capabilities and limitations and compares them with those offered by optical low-coherence interferometric schemes. We also describe applications of fluorescence interferometry to imaging, ranging, and profiling tasks and present experimental evidences of wide-field cross-sectional imaging with high resolution and large range of depth, as well as quantitative profiling with nanometer-level precision. Finally, we point out future research directions in fluorescence interferometry, such as fluorescence tomography of whole organisms and the extension to molecular interferometry by means of quantum dots and bioluminescence.

  18. A Geometric Application of the "Shepherd's Principle"

    ERIC Educational Resources Information Center

    Murrow, Gene

    1971-01-01

    The Shepherd's Principle (to count the number of sheep in a field, count the number of legs and divide by four) is applied to the problem of finding the number of different rectangles on an N by N checkerboard. (MM)

  19. Synthetic protein switches: design principles and applications.

    PubMed

    Stein, Viktor; Alexandrov, Kirill

    2015-02-01

    Protein switches are ubiquitous in biological signal transduction systems, enabling cells to sense and respond to a variety of molecular queues in a rapid, specific, and integrated fashion. Analogously, tailor-engineered protein switches with custom input and output functions have become invaluable research tools for reporting on distinct physiological states and actuating molecular functions in real time and in situ. Here, we analyze recent progress in constructing protein-based switches while assessing their potential in the assembly of defined signaling motifs. We anticipate such systems will ultimately pave the way towards a new generation of molecular diagnostics and facilitate the construction of artificial signaling systems that operate in parallel to the signaling machinery of a host cell for applications in synthetic biology.

  20. Applying best interests to persistent vegetative state--a principled distortion?

    PubMed Central

    Fenwick, A J

    1998-01-01

    "Best interests" is widely accepted as the appropriate foundation principle for medico-legal decisions concerning treatment withdrawal from patients in persistent vegetative state (PVS). Its application appears to progress logically from earlier use regarding legally incompetent patients. This author argues, however, that such confidence in the relevance of the principle of best interests to PVS is misplaced, and that current construction in this context is questionable on four specific grounds. Furthermore, it is argued that the resulting legal inconsistency is distorting both the principle itself and, more particularly, individual patient interests. PMID:9602994

  1. 7 CFR Appendix A to Part 277 - Principles for Determining Costs Applicable to Administration of the Food Stamp Program by State...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... provides funds to carry out programs, services, or activities in connection with administration of the Food... activities and operations of the State agency which are necessary to carry out the purposes of the Food Stamp... include procurement, payroll, personnel functions, maintenance and operation of space, data...

  2. 7 CFR Appendix A to Part 277 - Principles for Determining Costs Applicable to Administration of the Food Stamp Program by State...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... provides funds to carry out programs, services, or activities in connection with administration of the Food... activities and operations of the State agency which are necessary to carry out the purposes of the Food Stamp... include procurement, payroll, personnel functions, maintenance and operation of space, data...

  3. 7 CFR Appendix A to Part 277 - Principles for Determining Costs Applicable to Administration of the Food Stamp Program by State...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... provides funds to carry out programs, services, or activities in connection with administration of the Food... activities and operations of the State agency which are necessary to carry out the purposes of the Food Stamp... include procurement, payroll, personnel functions, maintenance and operation of space, data...

  4. 7 CFR Appendix A to Part 277 - Principles for Determining Costs Applicable to Administration of the Food Stamp Program by State...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... provides funds to carry out programs, services, or activities in connection with administration of the Food... activities and operations of the State agency which are necessary to carry out the purposes of the Food Stamp... include procurement, payroll, personnel functions, maintenance and operation of space, data...

  5. 7 CFR Appendix A to Part 277 - Principles for Determining Costs Applicable to Administration of the Food Stamp Program by State...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... provides funds to carry out programs, services, or activities in connection with administration of the Food... activities and operations of the State agency which are necessary to carry out the purposes of the Food Stamp... include procurement, payroll, personnel functions, maintenance and operation of space, data...

  6. Evolutionary principles and their practical application

    PubMed Central

    Hendry, Andrew P; Kinnison, Michael T; Heino, Mikko; Day, Troy; Smith, Thomas B; Fitt, Gary; Bergstrom, Carl T; Oakeshott, John; Jørgensen, Peter S; Zalucki, Myron P; Gilchrist, George; Southerton, Simon; Sih, Andrew; Strauss, Sharon; Denison, Robert F; Carroll, Scott P

    2011-01-01

    Evolutionary principles are now routinely incorporated into medicine and agriculture. Examples include the design of treatments that slow the evolution of resistance by weeds, pests, and pathogens, and the design of breeding programs that maximize crop yield or quality. Evolutionary principles are also increasingly incorporated into conservation biology, natural resource management, and environmental science. Examples include the protection of small and isolated populations from inbreeding depression, the identification of key traits involved in adaptation to climate change, the design of harvesting regimes that minimize unwanted life-history evolution, and the setting of conservation priorities based on populations, species, or communities that harbor the greatest evolutionary diversity and potential. The adoption of evolutionary principles has proceeded somewhat independently in these different fields, even though the underlying fundamental concepts are the same. We explore these fundamental concepts under four main themes: variation, selection, connectivity, and eco-evolutionary dynamics. Within each theme, we present several key evolutionary principles and illustrate their use in addressing applied problems. We hope that the resulting primer of evolutionary concepts and their practical utility helps to advance a unified multidisciplinary field of applied evolutionary biology. PMID:25567966

  7. Redesigning State Financial Aid: Principles to Guide State Aid Policymaking

    ERIC Educational Resources Information Center

    Pingel, Sarah; Sponsler, Brian A.

    2015-01-01

    Several factors create a challenging environment for individuals seeking financial support to complete a postsecondary degree program. In recognition of the challenges of paying for higher education, decision-makers at the federal and state levels support college-going with public policy. Through direct institutional allocations, need and…

  8. The principle of superposition and its application in ground-water hydraulics

    USGS Publications Warehouse

    Reilly, Thomas E.; Franke, O. Lehn; Bennett, Gordon D.

    1987-01-01

    The principle of superposition, a powerful mathematical technique for analyzing certain types of complex problems in many areas of science and technology, has important applications in ground-water hydraulics and modeling of ground-water systems. The principle of superposition states that problem solutions can be added together to obtain composite solutions. This principle applies to linear systems governed by linear differential equations. This report introduces the principle of superposition as it applies to ground-water hydrology and provides background information, discussion, illustrative problems with solutions, and problems to be solved by the reader.

  9. The principle of superposition and its application in ground-water hydraulics

    USGS Publications Warehouse

    Reilly, T.E.; Franke, O.L.; Bennett, G.D.

    1984-01-01

    The principle of superposition, a powerful methematical technique for analyzing certain types of complex problems in many areas of science and technology, has important application in ground-water hydraulics and modeling of ground-water systems. The principle of superposition states that solutions to individual problems can be added together to obtain solutions to complex problems. This principle applies to linear systems governed by linear differential equations. This report introduces the principle of superposition as it applies to groundwater hydrology and provides background information, discussion, illustrative problems with solutions, and problems to be solved by the reader. (USGS)

  10. Quantitative proteomics using SILAC: Principles, applications, and developments.

    PubMed

    Chen, Xiulan; Wei, Shasha; Ji, Yanlong; Guo, Xiaojing; Yang, Fuquan

    2015-09-01

    SILAC is based on direct addition of selected stable isotope amino acids into the cell culture medium, allowing superior quantitative analysis of the cellular proteome compared to other labeling methods. The great advantages of SILAC lie in its straight-forward implementation, quantitative accuracy, and reproducibility over chemical labeling or label-free quantification strategies, favoring its adoption for proteomic research. SILAC has been widely applied to characterize the proteomic changes between different biological samples, to investigate dynamic changes of protein PTMs, to distinguish specific interacting proteins in interaction proteomic analysis, and to analyze protein turnover in the proteome-wide scale. The present review summarizes the principles of SILAC technology, its applications in biological research, and the present state of this technology.

  11. Molecular biology and cytopathology. Principles and applications.

    PubMed

    Schmitt, Fernando C; Vielh, Philippe

    2012-12-01

    Some of the main applications of molecular techniques using cellular materials obtained from tumors by means of non-gynecological exfoliative cytology or fine-needle aspiration are briefly described in this review.

  12. Quantification of surface contamination: principles and applications

    SciTech Connect

    Vo-Dinh, T.

    1982-01-01

    The applications discussed in this paper underscore the usefulness and versatility of molecular luminescence spectroscopy as an efficient surface detection technique. The technique can be used not only as a qualitative characterization method, but also as a quantitative analytical tool to detect trace contaminants on surfaces. Recent advances in instrumentation and methodology have expanded the applicability of surface luminescence into many new problem areas. Trace organics are emphasized here.

  13. Faculty ethics: ideal principles with practical applications.

    PubMed

    Reybold, L Earle

    2009-01-01

    Ethics in higher education is the subject of intense public attention, with considerable focus on faculty roles and responsibilities. Media reports and scholarly research have documented egregious misconduct that includes plagiarism, falsification of data, illicit teacher-student relationships, and grading bias. These accounts of wrongdoing often portray faculty ethicality as only a legal issue of obeying rules and regulations, especially in the teaching and research roles. My discussion challenges this narrow perspective and argues that characterizations of faculty ethicality should take into account broader expectations for professionalism such as collegiality, respect, and freedom of inquiry. First, I review the general principles of faculty ethics developed by the American Association of University Professors, as well as professional codes of ethics in specific professional fields. Second, I juxtapose the experiences of women and minority faculty members in relation to these general codes of ethics. This section examines three issues that particularly affect women and minority faculty experiences of ethicality: "chilly and alienating" academic climates, "cultural taxation" of minority identity, and the snare of conventional reward systems. Third, I suggest practical strategies to reconcile faculty practice with codes of ethics. My challenge is to the faculty as a community of practice to engage professional ethics as social and political events, not just legal and moral failures.

  14. The Application of Gestalt Principles in Classroom Teaching

    ERIC Educational Resources Information Center

    Phillips, Mark

    1976-01-01

    Discusses the application of principles and techniques derived from Gestalt therapy to education. Initial investigations of the results of these applications have noted significant benefits to both teachers and students, including personal control, self-knowledge and self-esteem. For journal availability, see SO 504 730. (Author/DB)

  15. Nursing application of Bobath principles in stroke care.

    PubMed

    Passarella, P M; Lewis, N

    1987-04-01

    The nursing approach in the care of stroke patients has a direct impact on functional outcome. Nursing application of Bobath principles in stroke care offers a nursing focus on involvement of the affected side; facilitation of normal tone, posture, and movement; and development of more normal function. A research study evaluating the functional gains of stroke patients demonstrated a significant level of functional improvement in those treated with Bobath principles over stroke patients treated with the traditional nursing approach. Practical methods for applying Bobath principles in patient care activities are described. These therapeutic methods provide nurses with the means to maximize stroke patients' potential and further influence their functional recovery.

  16. Digital imaging and video: principles and applications.

    PubMed

    Rosen, Andrew L; Hausman, Michael

    2003-01-01

    Digital imaging has provided orthopaedic surgeons with new, powerful tools that offer a multitude of applications. Already integral to several common medical devices, digital images can be used for case documentation and presentation as well as for diagnostic and surgical patient care information. Educational presentation has been transformed by the use of computers and digital projectors. Understanding the basic foundations of digital imaging technology is important for effectively creating digital images, videos, and presentations.

  17. Principles and clinical applications of image analysis.

    PubMed

    Kisner, H J

    1988-12-01

    Image processing has traveled to the lunar surface and back, finding its way into the clinical laboratory. Advances in digital computers have improved the technology of image analysis, resulting in a wide variety of medical applications. Offering improvements in turnaround time, standardized systems, increased precision, and walkaway automation, digital image analysis has likely found a permanent home as a diagnostic aid in the interpretation of microscopic as well as macroscopic laboratory images.

  18. Granular Salt Summary: Reconsolidation Principles and Applications

    SciTech Connect

    Hansen, Frank; Popp, Till; Wieczorek, Klaus; Stuehrenberg, Dieter

    2014-07-01

    The purposes of this paper are to review the vast amount of knowledge concerning crushed salt reconsolidation and its attendant hydraulic properties (i.e., its capability for fluid or gas transport) and to provide a sufficient basis to understand reconsolidation and healing rates under repository conditions. Topics covered include: deformation mechanisms and hydro-mechanical interactions during reconsolidation; the experimental data base pertaining to crushed salt reconsolidation; transport properties of consolidating granulated salt and provides quantitative substantiation of its evolution to characteristics emulating undisturbed rock salt; and extension of microscopic and laboratory observations and data to the applicable field scale.

  19. Disc-based microarrays: principles and analytical applications.

    PubMed

    Morais, Sergi; Puchades, Rosa; Maquieira, Ángel

    2016-07-01

    The idea of using disk drives to monitor molecular biorecognition events on regular optical discs has received considerable attention during the last decade. CDs, DVDs, Blu-ray discs and other new optical discs are universal and versatile supports with the potential for development of protein and DNA microarrays. Besides, standard disk drives incorporated in personal computers can be used as compact and affordable optical reading devices. Consequently, a CD technology, resulting from the audio-video industry, has been used to develop analytical applications in health care, environmental monitoring, food safety and quality assurance. The review presents and critically evaluates the current state of the art of disc-based microarrays with illustrative examples, including past, current and future developments. Special mention is made of the analytical developments that use either chemically activated or raw standard CDs where proteins, oligonucleotides, peptides, haptens or other biological probes are immobilized. The discs are also used to perform the assays and must maintain their readability with standard optical drives. The concept and principle of evolving disc-based microarrays and the evolution of disk drives as optical detectors are also described. The review concludes with the most relevant uses ordered chronologically to provide an overview of the progress of CD technology applications in the life sciences. Also, it provides a selection of important references to the current literature. Graphical Abstract High density disc-based microarrays.

  20. Z-View diffractive wavefront sensor: principle and applications

    NASA Astrophysics Data System (ADS)

    Liu, Yueai; Warden, Laurence; Dillon, Keith; Mills, Gary; Dreher, Andreas

    2005-12-01

    A novel wavefront sensor (Z-View TM) using a two dimensional diffractive grating has been developed at Ophthonix, Inc. Based on the Talbot self-imaging theory, a CMOS camera is placed behind the grating to capture the first Talbot image of the aberrated wavefront. This captured Talbot image is analyzed to recover the wavefront aberration. The diffractive grating wavefront sensor has been used in Ophthonix's Z-View Aberrometer, an objective refractive vision assessment system which is now commercially used in optometrist's offices/clinics across the United States of America. Coupled with a deformable mirror and other auxiliary optics systems, Z-View wavefront sensor forms the A-View adaptive optic vision correction system at Ophthonix. This A-View system is used to study the effect of complete wavefront correction in human vision, and has potential application in prescribing Ophthonix's wavefront-guided iZon TM lenses. In this paper, the wavefront sensing principle of this novel diffractive wavefront sensor and its applications will be discussed.

  1. S-layers: principles and applications

    PubMed Central

    Sleytr, Uwe B; Schuster, Bernhard; Egelseer, Eva-Maria; Pum, Dietmar

    2014-01-01

    Monomolecular arrays of protein or glycoprotein subunits forming surface layers (S-layers) are one of the most commonly observed prokaryotic cell envelope components. S-layers are generally the most abundantly expressed proteins, have been observed in species of nearly every taxonomical group of walled bacteria, and represent an almost universal feature of archaeal envelopes. The isoporous lattices completely covering the cell surface provide organisms with various selection advantages including functioning as protective coats, molecular sieves and ion traps, as structures involved in surface recognition and cell adhesion, and as antifouling layers. S-layers are also identified to contribute to virulence when present as a structural component of pathogens. In Archaea, most of which possess S-layers as exclusive wall component, they are involved in determining cell shape and cell division. Studies on structure, chemistry, genetics, assembly, function, and evolutionary relationship of S-layers revealed considerable application potential in (nano)biotechnology, biomimetics, biomedicine, and synthetic biology. PMID:24483139

  2. Total internal reflection ellipsometry: principles and applications.

    PubMed

    Arwin, Hans; Poksinski, Michal; Johansen, Knut

    2004-05-20

    A concept for a measurement technique based on ellipsometry in conditions of total internal reflection is presented. When combined with surface plasmon resonance (SPR) effects, this technique becomes powerful for monitoring and analyzing adsorption and desorption on thin semitransparent metal films as well as for analyzing the semitransparent films themselves. We call this technique total internal reflection ellipsometry (TIRE). The theory of ellipsometry under total internal reflection combined with SPR is discussed for some simple cases. For more advanced cases and to prove the concept, simulations are performed with the Fresnel formalism. The use of TIRE is exemplified by applications in protein adsorption, corrosion monitoring, and adsorption from opaque liquids on metal surfaces. Simulations and experiments show greatly enhanced thin-film sensitivity compared with ordinary ellipsometry.

  3. S-layers: principles and applications.

    PubMed

    Sleytr, Uwe B; Schuster, Bernhard; Egelseer, Eva-Maria; Pum, Dietmar

    2014-09-01

    Monomolecular arrays of protein or glycoprotein subunits forming surface layers (S-layers) are one of the most commonly observed prokaryotic cell envelope components. S-layers are generally the most abundantly expressed proteins, have been observed in species of nearly every taxonomical group of walled bacteria, and represent an almost universal feature of archaeal envelopes. The isoporous lattices completely covering the cell surface provide organisms with various selection advantages including functioning as protective coats, molecular sieves and ion traps, as structures involved in surface recognition and cell adhesion, and as antifouling layers. S-layers are also identified to contribute to virulence when present as a structural component of pathogens. In Archaea, most of which possess S-layers as exclusive wall component, they are involved in determining cell shape and cell division. Studies on structure, chemistry, genetics, assembly, function, and evolutionary relationship of S-layers revealed considerable application potential in (nano)biotechnology, biomimetics, biomedicine, and synthetic biology.

  4. 4D electron microscopy: principles and applications.

    PubMed

    Flannigan, David J; Zewail, Ahmed H

    2012-10-16

    The transmission electron microscope (TEM) is a powerful tool enabling the visualization of atoms with length scales smaller than the Bohr radius at a factor of only 20 larger than the relativistic electron wavelength of 2.5 pm at 200 keV. The ability to visualize matter at these scales in a TEM is largely due to the efforts made in correcting for the imperfections in the lens systems which introduce aberrations and ultimately limit the achievable spatial resolution. In addition to the progress made in increasing the spatial resolution, the TEM has become an all-in-one characterization tool. Indeed, most of the properties of a material can be directly mapped in the TEM, including the composition, structure, bonding, morphology, and defects. The scope of applications spans essentially all of the physical sciences and includes biology. Until recently, however, high resolution visualization of structural changes occurring on sub-millisecond time scales was not possible. In order to reach the ultrashort temporal domain within which fundamental atomic motions take place, while simultaneously retaining high spatial resolution, an entirely new approach from that of millisecond-limited TEM cameras had to be conceived. As shown below, the approach is also different from that of nanosecond-limited TEM, whose resolution cannot offer the ultrafast regimes of dynamics. For this reason "ultrafast electron microscopy" is reserved for the field which is concerned with femtosecond to picosecond resolution capability of structural dynamics. In conventional TEMs, electrons are produced by heating a source or by applying a strong extraction field. Both methods result in the stochastic emission of electrons, with no control over temporal spacing or relative arrival time at the specimen. The timing issue can be overcome by exploiting the photoelectric effect and using pulsed lasers to generate precisely timed electron packets of ultrashort duration. The spatial and temporal resolutions

  5. Digital mammography: physical principles and future applications.

    PubMed

    Gambaccini, Mauro; Baldelli, Paola

    2003-01-01

    Mammography is currently considered the best tool for the detection of breast cancer, pathology with a rate of incidence in constant increase. To produce the radiological picture a screen film combination is conventionally used. One of the inherent limitations of screen- film combination is the fact that the detection, display and storage processes are one and the same, making it impossible to separately optimize each stage. These limitations can be overcome with digital systems. In this work we evaluate the main characteristics of digital detectors available on the market and we compare the performance of digital and conventional systems. Digital mammography, due to the possibility to process images, offers many potential advantages, among these the possibility to introduce the dual-energy technique which employs the composition of two digital images obtained with two different energies to enhance the inherent contrast of pathologies by removing the uniform background. This technique was previously tested by using synchrotron monochromatic beam and a digital detector, and then the Senographe 2000D full-field digital system manufactured by GE Medical Systems. In this work we present preliminary results and the future applications of this technique.

  6. Keynote Address: Principles and applications of biotelemetry

    NASA Astrophysics Data System (ADS)

    Jeutter, Dean C.

    1990-06-01

    Biotelemetry provides a means for monitoring and studying human and animal physiologic functions from a remote site with the goals of minimally encumbering or disturbing normal activity allowing ambulatory freedom and often to place the investigator out of harm''s way. Since the early 1950''s biotelemetry has been applied to a wide variety of subjects ranging in size from bees to whales over distances from several feet to thousands of miles. The evolution in sophistication miniaturization and reliability has paralleled the improvements of electronic components and assembly capabilities available to investigators. Modern biotelemetry began as a single transistor Endoradiosonde but now is found in sophisticated miniaturized microcontroller implementations. Signals derived from physiologic transducers have been encoded and formatted in many different ways in an effort to improve transmission reliability and carrier signals have included radio sound and light in air space and water. Power sources have been developed using both primary and secondary cells. Power can now be transferred at radio frequency across the tissues to implanted biotelemeters and their rechargeable batteries to provide for long operational lifetimes. The field of biotelemetry is truly exciting challenging and diverse in new circuit realizations and applications to living subjects.

  7. Twelve Principles for Green Energy Storage in Grid Applications.

    PubMed

    Arbabzadeh, Maryam; Johnson, Jeremiah X; Keoleian, Gregory A; Rasmussen, Paul G; Thompson, Levi T

    2016-01-19

    The introduction of energy storage technologies to the grid could enable greater integration of renewables, improve system resilience and reliability, and offer cost effective alternatives to transmission and distribution upgrades. The integration of energy storage systems into the electrical grid can lead to different environmental outcomes based on the grid application, the existing generation mix, and the demand. Given this complexity, a framework is needed to systematically inform design and technology selection about the environmental impacts that emerge when considering energy storage options to improve sustainability performance of the grid. To achieve this, 12 fundamental principles specific to the design and grid application of energy storage systems are developed to inform policy makers, designers, and operators. The principles are grouped into three categories: (1) system integration for grid applications, (2) the maintenance and operation of energy storage, and (3) the design of energy storage systems. We illustrate the application of each principle through examples published in the academic literature, illustrative calculations, and a case study with an off-grid application of vanadium redox flow batteries (VRFBs). In addition, trade-offs that can emerge between principles are highlighted.

  8. Basic principles, methodology, and applications of remote sensing in agriculture

    NASA Technical Reports Server (NTRS)

    Moreira, M. A. (Principal Investigator); Deassuncao, G. V.

    1984-01-01

    The basic principles of remote sensing applied to agriculture and the methods used in data analysis are described. Emphasis is placed on the importance of developing a methodology that may help crop forecast, basic concepts of spectral signatures of vegetation, the methodology of the LANDSAT data utilization in agriculture, and the remote sensing program application of INPE (Institute for Space Research) in agriculture.

  9. The Application of Artificial Intelligence Principles to Teaching and Training

    ERIC Educational Resources Information Center

    Shaw, Keith

    2008-01-01

    This paper compares and contrasts the use of AI principles in industrial training with more normal computer-based training (CBT) approaches. A number of applications of CBT are illustrated (for example simulations, tutorial presentations, fault diagnosis, management games, industrial relations exercises) and compared with an alternative approach…

  10. Principles and Application of Heterodyne Scanning Tunnelling Spectroscopy

    PubMed Central

    Matsuyama, Eiji; Kondo, Takahiro; Oigawa, Haruhiro; Guo, Donghui; Nemoto, Shojiro; Nakamura, Junji

    2014-01-01

    Detection of the extremely weak signals in spectroscopy over an extremely wide frequency region is central to diverse sciences, including materials science, biology, astronomy and chemistry. Here we show a new type of atomic-scale spectroscopy, heterodyne scanning tunnelling spectroscopy (HSTS), which is based on the innovative application of the nonlinear heterodyne-mixing detection at the metal-insulator-metal (MIM) heterojunction of STM tip–vacuum–sample. The principle of HSTS is identical to that of the Atacama Large Millimeter Array (ALMA) space telescope in terms of using heterojunction for detecting extremely weak signals by converting from terahertz region to lower frequency regions. The MIM detector of ALMA, which is composed of niobium–titanium–nitride (NbTiN) tip-insulator-NbTiN, is very similar in shape and size to that of HSTS. We successfully detect a heterodyne beat signal f3 (= |f2 − f1|) and intermodulation distortion via tunnelling current by superimposing two different AC signals, f1 and f2, onto the DC tunnelling current at a highly oriented pyrolytic graphite (HOPG) surface. We then obtain spectra of the localized electronic states of HOPG by using f3. HSTS can be performed with a high resolution and over a wide energy range, including the terahertz range. PMID:25342108

  11. First-principles Calculation of Excited State Spectra in QCD

    SciTech Connect

    Jozef Dudek,Robert Edwards,Michael Peardon,David Richards,Christopher Thomas

    2011-05-01

    Recent progress at understanding the excited state spectra of mesons and baryons is described. I begin by outlining the application of the variational method to compute the spectrum of QCD, and then present results for the excited meson spectrum, with continuum quantum numbers of the states clearly delineated. I emphasise the need to extend the calculation to encompass multi-hadron contributions, and describe a recent calculation of the I=2 pion-pion energy-dependent phase shifts as a precursor to the study of channels with resonant behavior. I conclude with recent results for the low lying baryon spectrum, and the prospects for future calculations.

  12. STATE OF THE SCIENCE OF MATERNAL-INFANT BONDING: A PRINCIPLE-BASED CONCEPT ANALYSIS

    PubMed Central

    Bicking Kinsey, Cara; Hupcey, Judith E.

    2013-01-01

    Objective To provide a principle-based analysis of the concept of maternal-infant bonding. Design Principle-based method of concept analysis for which the data set included 44 articles published in the last decade from Pubmed, CINAHL, and PyschINFO/PsychARTICLES. Setting Literature inclusion criteria were English language, articles published in the last decade, peer-reviewed journal articles and commentary on published work, and human populations. Measurement and Findings After brief review of the history of maternal-infant bonding, a principle-based concept analysis was completed to examine the state of the science with regard to this concept. The concept was critically examined according to the clarity of definition (epistemological principle), applicability of the concept (pragmatic principle), consistency in use and meaning (linguistic principle), and differentiation of the concept from related concepts (logical principle). Analysis of the concept revealed: (1) maternal-infant bonding describes maternal feelings and emotions towards her infant. Evidence that the concept encompasses behavioral or biological components was limited; (2) the concept is clearly operationalized in the affective domain; and (3) maternal-infant bonding is linguistically confused with attachment, although the boundaries between the concepts are clearly delineated. Key Conclusion Despite widespread use of the concept, maternal-infant bonding is at times superficially developed and subject to confusion with related concepts. Concept clarification is warranted. A theoretical definition of the concept of maternal-infant bonding was developed to aid in the clarification, but more research is necessary to further clarify and advance the concept. Implications for Practice Nurse midwives and other practitioners should use the theoretical definition of maternal-infant bonding as a preliminary guide to identification and understanding of the concept in clinical practice. PMID:23452661

  13. Brain-Compatible Learning: Principles and Applications in Athletic Training

    PubMed Central

    2003-01-01

    Objective: To discuss the principles of brain-compatible learning research and provide insights into how this research may be applied in athletic training education to benefit the profession. Background: In the past decade, new brain-imaging techniques have allowed us to observe the brain while it is learning. The field of neuroscience has produced a body of empirical data that provides a new understanding of how we learn. This body of data has implications in education, although the direct study of these implications is in its infancy. Description: An overview of how the brain learns at a cellular level is provided, followed by a discussion of the principles of brain-compatible learning. Applications of these principles and implications for the field of athletic training education are also offered. Application: Many educational-reform fads have garnered attention in the past. Brain-compatible learning will not likely be one of those, as its origin is in neuroscience, not education. Brain-compatible learning is not an educational-reform movement. It does not prescribe how to run your classroom or offer specific techniques to use. Rather, it provides empirical data about how the brain learns and suggests guidelines to be considered while preparing lessons for your students. These guidelines may be incorporated into every educational setting, with every type of curriculum and every age group. The field of athletic training lends itself well to many of the basic principles of brain-compatible learning. PMID:16558681

  14. Low thermal mass gas chromatography: principles and applications.

    PubMed

    Luong, Jim; Gras, Ronda; Mustacich, Robert; Cortes, Hernan

    2006-01-01

    In gas chromatography (GC), temperature programming is often considered to be the second most important parameter to control, the first being column selectivity. A radically new GC technology to achieve ultrafast temperature programming with an unprecedented cool down time and low power consumption has recently become available. This technology is referred to as low thermal mass GC (LTMGC). Though the technology has its roots in resistive heating, which forms the basis of principle and design concept, the approach taken to achieve ultrafast heating and cool down time by LTMGC represents a significant break-through in GC. Despite some rectifiable shortcomings, LTMGC has proven to be an ideal methodology to deliver near/real time GC data, high precision, and high throughput applications. It is a new approach for modern high-speed GC. This paper documents the fundamental design principles behind LTMGC, performance data, and examples of applications investigated.

  15. Application of trajectory optimization principles to minimize aircraft operating costs

    NASA Technical Reports Server (NTRS)

    Sorensen, J. A.; Morello, S. A.; Erzberger, H.

    1979-01-01

    This paper summarizes various applications of trajectory optimization principles that have been or are being devised by both government and industrial researchers to minimize aircraft direct operating costs (DOC). These costs (time and fuel) are computed for aircraft constrained to fly over a fixed range. Optimization theory is briefly outlined, and specific algorithms which have resulted from application of this theory are described. Typical results which demonstrate use of these algorithms and the potential savings which they can produce are given. Finally, need for further trajectory optimization research is presented.

  16. Development, principles, and applications of automated ice fabric analyzers.

    PubMed

    Wilen, L A; Diprinzio, C L; Alley, R B; Azuma, N

    2003-09-01

    We review the recent development of automated techniques to determine the fabric and texture of polycrystalline ice. The motivation for the study of ice fabric is first outlined. After a brief introduction to the relevant optical concepts, the classic manual technique for fabric measurement is described, along with early attempts at partial automation. Then, the general principles behind fully automated techniques are discussed. We describe in some detail the similarities and differences of the three modern instruments recently developed for ice fabric studies. Next, we discuss briefly X-ray, radar, and acoustic techniques for ice fabric characterization. We also discuss the principles behind automated optical techniques to measure fabric in quartz rock samples. Finally, examples of new applications that have been facilitated by the development of the ice fabric instruments are presented.

  17. The INSAR technique: its principle and applications to mapping the deformation field of earthquakes

    NASA Astrophysics Data System (ADS)

    Shan, Xin-Jian; Ye, Hong

    1998-11-01

    The development, state-of-art and prospects of application of the radar remote sensing technique are presented. The principle of the INSAR (Interferometric Synthetic Aperture Radar) technique is expounded in more details. Some applications of this technique in measuring seismic dislocations are given. Finally, it is pointed out that INSAR has a non-replaceable application potential in observing ground surface vertical deformations; it would provide an entirely new means and method for monitoring the dynamic field of earthquakes and give an extremely great impetus to the future earthquake prediction work.

  18. Principles of contemporary amputation rehabilitation in the United States, 2013.

    PubMed

    Meier, Robert H; Heckman, Jeffrey T

    2014-02-01

    Providing rehabilitation services for the person with an amputation has become more difficult in today's health care environment. Amputation rehabilitation calls for specialized, multidisciplinary rehabilitation training. In examining the principles of amputation rehabilitation, one must understand the lessons learned from the Veterans Affairs Amputation System of Care and return to the founding principles of rehabilitation medicine. Persons with amputations must be reevaluated in a tight program of follow-up care.

  19. Remote sensing applied to agriculture: Basic principles, methodology, and applications

    NASA Technical Reports Server (NTRS)

    Dejesusparada, N. (Principal Investigator); Mendonca, F. J.

    1981-01-01

    The general principles of remote sensing techniques as applied to agriculture and the methods of data analysis are described. the theoretical spectral responses of crops; reflectance, transmittance, and absorbtance of plants; interactions of plants and soils with reflectance energy; leaf morphology; and factors which affect the reflectance of vegetation cover are dicussed. The methodologies of visual and computer-aided analyses of LANDSAT data are presented. Finally, a case study wherein infrared film was used to detect crop anomalies and other data applications are described.

  20. Principles of proteomics and its applications in cancer.

    PubMed

    Chuthapisith, S; Layfield, R; Kerr, I D; Eremin, O

    2007-02-01

    During the past decade, genomic analyses have been introduced into cancer studies with variable success. It has become recognised, however, that genomic techniques in isolation are insufficient to study the complex pathways of carcinogenesis; this has led to the application of proteomic techniques, which allow for the reliable analysis of complex mixtures of proteins. This article reviews the basic principles of proteomics, methods currently used in proteomics including two-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS), and the application of proteomics in cancer research. Currently, proteomic technology has been used in two main areas of cancer research: early diagnosis and treatment (included prediction of response to treatment and targeting novel cancer agents). The initial results from both in vitro and in vivo studies are impressive. These technologies, particularly when combined with genomic analyses, will provide valuable insights into the molecular basis of carcinogenesis and the development of more effective anti-cancer therapies.

  1. Nanotube field electron emission: principles, development, and applications

    NASA Astrophysics Data System (ADS)

    Li, Yunhan; Sun, Yonghai; Yeow, J. T. W.

    2015-06-01

    There is a growing trend to apply field emission (FE) electron sources in vacuum electronic devices due to their fast response, high efficiency and low energy consumption compared to thermionic emission ones. Carbon nanotubes (CNTs) have been regarded as a promising class of electron field emitters since the 1990s and have promoted the development of FE technology greatly because of their high electrical and thermal conductivity, chemical stability, high aspect ratio and small size. Recent studies have shown that FE from CNTs has the potential to replace conventional thermionic emission in many areas and that it exhibits advanced features in practical applications. Consequently, FE from nanotubes and applications thereof have attracted much attention. This paper provides a comprehensive review of both recent advances in CNT field emitters and issues related to applications of CNT based FE. FE theories and principles are introduced, and the early development of field emitters is related. CNT emitter types and their FE performance are discussed. The current situation for applications based on nanotube FE is reviewed. Although challenges remain, the tremendous progress made in CNT FE over the past ten years indicates the field’s development potential.

  2. Basic humanitarian principles applicable to non-nationals.

    PubMed

    Goodwin-gill, G S; Jenny, R K; Perruchoud, R

    1985-01-01

    This article examines the general status in international law of certain fundamental human rights to determine the minimum "no derogation" standards, and then surveys a number of formal agreements between stages governing migration matters, while examining some of the standard-setting work undertaken by the International Labor Organization (ILO) and other institutions. Article 13 of the Universal Declaration of Human Rights, proclaims the right of everyone to leave any country, including his or her own. The anti-discrimination provision is widely drawn and includes national or social origin, birth, or other status. Non-discrimination is frequently the core issue in migration matters; it offers the basis for a principles approach to questions involving non-nationals and their methodological analysis, as well as a standard for the progressive elaboration of institutions and practices. As a general rule, ILO conventions give particular importance to the principle of choice of methods by states for the implementation of standards, as well as to the principle of progressive implementation. Non-discrimination implies equality of opportunity in the work field, inremuneration, job opportunity, trade union rights and benefits, social security, taxation, medical treatment, and accommodation; basic legal guarantees are also matters of concern to migrant workers, including termination of employment, non-renewal of work permits, and expulsion. The generality of human rights is due not because the individual is or is not a member of a partucular group, and claims to such rights are not determinable according to membership, but according to the character of the right in question. The individualized aspect of fundamental human rights requires a case-by-case consideration of claims, and the recognition that to all persons now certain special duties are owed.

  3. Principles and application of LIMS in mouse clinics.

    PubMed

    Maier, Holger; Schütt, Christine; Steinkamp, Ralph; Hurt, Anja; Schneltzer, Elida; Gormanns, Philipp; Lengger, Christoph; Griffiths, Mark; Melvin, David; Agrawal, Neha; Alcantara, Rafael; Evans, Arthur; Gannon, David; Holroyd, Simon; Kipp, Christian; Raj, Navis Pretheeba; Richardson, David; LeBlanc, Sophie; Vasseur, Laurent; Masuya, Hiroshi; Kobayashi, Kimio; Suzuki, Tomohiro; Tanaka, Nobuhiko; Wakana, Shigeharu; Walling, Alison; Clary, David; Gallegos, Juan; Fuchs, Helmut; de Angelis, Martin Hrabě; Gailus-Durner, Valerie

    2015-10-01

    Large-scale systemic mouse phenotyping, as performed by mouse clinics for more than a decade, requires thousands of mice from a multitude of different mutant lines to be bred, individually tracked and subjected to phenotyping procedures according to a standardised schedule. All these efforts are typically organised in overlapping projects, running in parallel. In terms of logistics, data capture, data analysis, result visualisation and reporting, new challenges have emerged from such projects. These challenges could hardly be met with traditional methods such as pen & paper colony management, spreadsheet-based data management and manual data analysis. Hence, different Laboratory Information Management Systems (LIMS) have been developed in mouse clinics to facilitate or even enable mouse and data management in the described order of magnitude. This review shows that general principles of LIMS can be empirically deduced from LIMS used by different mouse clinics, although these have evolved differently. Supported by LIMS descriptions and lessons learned from seven mouse clinics, this review also shows that the unique LIMS environment in a particular facility strongly influences strategic LIMS decisions and LIMS development. As a major conclusion, this review states that there is no universal LIMS for the mouse research domain that fits all requirements. Still, empirically deduced general LIMS principles can serve as a master decision support template, which is provided as a hands-on tool for mouse research facilities looking for a LIMS.

  4. Ion-Exchange Chromatography: Basic Principles and Application.

    PubMed

    Cummins, Philip M; Rochfort, Keith D; O'Connor, Brendan F

    2017-01-01

    Ion-Exchange Chromatography (IEC) allows for the separation of ionizable molecules on the basis of differences in charge properties. Its large sample-handling capacity, broad applicability (particularly to proteins and enzymes), moderate cost, powerful resolving ability, and ease of scale-up and automation have led to it becoming one of the most versatile and widely used of all liquid chromatography (LC) techniques. In this chapter, we review the basic principles of IEC, as well as the broader criteria for selecting IEC conditions. By way of further illustration, we outline basic laboratory protocols to partially purify a soluble serine peptidase from bovine whole brain tissue, covering crude tissue extract preparation through to partial purification of the target enzyme using anion-exchange chromatography. Protocols for assaying total protein and enzyme activity in both pre- and post-IEC fractions are also described.

  5. [Universal ethical principles and their application in clinical drug trials].

    PubMed

    Gonorazky, Sergio Eduardo

    2015-03-01

    Since 1931, and especially since the Nuremberg Code of 1947, an increasing number of declarations, regulations, norms, guidelines, laws, resolutions, and rules intended to create conditions for better protection of subjects participating in research studies have been published, although some have meant setbacks in the human rights of vulnerable populations. As such, violations of the dignity of experimental subjects in clinical trials continue. What researchers investigate and how the research is done, the quality and transparency of the data, and the analysis and the publication of results (of both raw and processed data) respond to the financial interests of the pharmaceutical companies, coming into permanent tension with bioethical principles and the needs of society. The active participation of civil society is necessary to make it so that pharmaceutical research, results and applications subordinate economic benefits to the protection of human rights.

  6. Ultrafast optical imaging technology: principles and applications of emerging methods

    NASA Astrophysics Data System (ADS)

    Mikami, Hideharu; Gao, Liang; Goda, Keisuke

    2016-09-01

    High-speed optical imaging is an indispensable technology for blur-free observation of fast transient dynamics in virtually all areas including science, industry, defense, energy, and medicine. High temporal resolution is particularly important for microscopy as even a slow event appears to occur "fast" in a small field of view. Unfortunately, the shutter speed and frame rate of conventional cameras based on electronic image sensors are significantly constrained by their electrical operation and limited storage. Over the recent years, several unique and unconventional approaches to high-speed optical imaging have been reported to circumvent these technical challenges and achieve a frame rate and shutter speed far beyond what can be reached with the conventional image sensors. In this article, we review the concepts and principles of such ultrafast optical imaging methods, compare their advantages and disadvantages, and discuss an entirely new class of applications that are possible using them.

  7. Generic approvals of irradiated foods: Application of the chemiclearance principle

    SciTech Connect

    Taub, I.A.

    1996-10-01

    The use of irradiation for food preservation requires premarket approval primarily by the Food and Drug Administration (FDA), based on data establishing the safety of the process. Several approvals have already been granted on the strength of extensive microbiological, genotoxicity, nutritional, and animal feeding studies. Extending approval to other foods that are pasteurized or are sterilized by treatment to high doses, and consequently storable of ambient temperatures, does not necessarily have to involve comprehensive research on each and every food item. Generic approvals of classes of food is possible, because of the commonality in the response of similar foods to treatment by ionizing irradiation. This commonality is the basis for the chemiclearance principle, by which it can be shown that compositionally similar conditions are toxicologically equivalent. The use of different chemical investigations into radiolytic effects in both low and high dose irradiated muscle foods will be discussed to illustrate the application of this approach for obtaining approvals, nationally and internationally.

  8. Active nondestructive assay of nuclear materials: principles and applications

    SciTech Connect

    Gozani, Tsahi

    1981-01-01

    The purpose of this book is to present, coherently and comprehensively, the wealth of available but scattered information on the principles and applications of active nondestructive analysis (ANDA). Chapters are devoted to the following: background and overview; interactions of neutrons with matter; interactions of ..gamma..-rays with matter; neutron production and sources; ..gamma..-ray production and sources; effects of neutron and ..gamma..-ray transport in bulk media; signatures of neutron- and photon-induced fissions; neutron and photon detection systems and electronics; representative ANDA systems; and instrument analysis, calibration, and measurement control for ANDA. Each chapter has an introductory section describing the relationship of the topic of that chapter to ANDA. Each chapter ends with a section that summarizes the main results and conclusions of the chapter, and a reference list.

  9. Hot-melt extrusion--basic principles and pharmaceutical applications.

    PubMed

    Lang, Bo; McGinity, James W; Williams, Robert O

    2014-09-01

    Originally adapted from the plastics industry, the use of hot-melt extrusion has gained favor in drug delivery applications both in academia and the pharmaceutical industry. Several commercial products made by hot-melt extrusion have been approved by the FDA, demonstrating its commercial feasibility for pharmaceutical processing. A significant number of research articles have reported on advances made regarding the pharmaceutical applications of the hot-melt extrusion processing; however, only limited articles have been focused on general principles regarding formulation and process development. This review provides an in-depth analysis and discussion of the formulation and processing aspects of hot-melt extrusion. The impact of physicochemical properties of drug substances and excipients on formulation development using a hot-melt extrusion process is discussed from a material science point of view. Hot-melt extrusion process development, scale-up, and the interplay of formulation and process attributes are also discussed. Finally, recent applications of hot-melt extrusion to a variety of dosage forms and drug substances have also been addressed.

  10. Bioreactors in tissue engineering - principles, applications and commercial constraints.

    PubMed

    Hansmann, Jan; Groeber, Florian; Kahlig, Alexander; Kleinhans, Claudia; Walles, Heike

    2013-03-01

    Bioreactor technology is vital for tissue engineering. Usually, bioreactors are used to provide a tissue-specific physiological in vitro environment during tissue maturation. In addition to this most obvious application, bioreactors have the potential to improve the efficiency of the overall tissue-engineering concept. To date, a variety of bioreactor systems for tissue-specific applications have been developed. Of these, some systems are already commercially available. With bioreactor technology, various functional tissues of different types were generated and cultured in vitro. Nevertheless, these efforts and achievements alone have not yet led to many clinically successful tissue-engineered implants. We review possible applications for bioreactor systems within a tissue-engineering process and present basic principles and requirements for bioreactor development. Moreover, the use of bioreactor systems for the expansion of clinically relevant cell types is addressed. In contrast to cell expansion, for the generation of functional three-dimensional tissue equivalents, additional physical cues must be provided. Therefore, bioreactors for musculoskeletal tissue engineering are discussed. Finally, bioreactor technology is reviewed in the context of commercial constraints.

  11. Liquid-state paramagnetic relaxation from first principles

    NASA Astrophysics Data System (ADS)

    Rantaharju, Jyrki; Vaara, Juha

    2016-10-01

    We simulate nuclear and electron spin relaxation rates in a paramagnetic system from first principles. Sampling a molecular dynamics trajectory with quantum-chemical calculations produces a time series of the instantaneous parameters of the relevant spin Hamiltonian. The Hamiltonians are, in turn, used to numerically solve the Liouville-von Neumann equation for the time evolution of the spin density matrix. We demonstrate the approach by studying the aqueous solution of the Ni2 + ion. Taking advantage of Kubo's theory, the spin-lattice (T1) and spin-spin (T2) relaxation rates are extracted from the simulations of the time dependence of the longitudinal and transverse magnetization, respectively. Good agreement with the available experimental data is obtained by the method.

  12. First-principles modeling of materials for nuclear energy applications

    SciTech Connect

    Dmitriev, Andrey I. Nikonov, Anton Yu.; Ponomareva, Alena V.; Abrikosov, Igor A.; Barannikova, Svetlana A.

    2014-11-14

    We discuss recent developments in the field of ab initio electronic structure theory and its use for studies of materials for nuclear energy applications. We review state-of-the-art simulation methods that allow for an efficient treatment of effects due to chemical and magnetic disorder, and illustrate their predictive power with examples of two materials systems, Fe-Cr-Ni alloys and Zr-Nb alloys.

  13. Applications of the holographic principle in string theory

    NASA Astrophysics Data System (ADS)

    Button, Bradly Kevin

    The holographic principle has become an extraordinary tool in theoretical physics, most notably in the form of the Anti-deSitter Conformal Field Theory (AdS/CFT) correspondence, in which classical gravitational degrees of freedom in N-dimensions are related quantum field theory degrees of freedom in N -- 1 dimensions in the limit of a large number of fields. Here we present an account of the AdS/CFT correspondence, also known as the gauge/gravity duality, from its origins in the large N 'tHooft expansion, up to Maldacena's proposal that type IIB string theory in the presence of D-branes at low energy is dual to an N = 4, d = 4, U(N) super Yang-Mills on AdS5 . S5 . We begin with an extensive review of (super)string theory including D-branes. We then present the general formulation of the AdS/CFT in the supergravity background of AdS5 x S5 , along with several examples of how it is used in terms of the identification of bulk fields with operators on the boundary of a CFT. We move on to discuss two applications of the gauge/gravity duality. The first is the application of the holographic gauge/gravity correspondence to the QCD k-string. The second applies the AdS/CFT formalism to a Kerr black hole solution embedded in 10-dimensional heterotic sting theory. These two applications of the holographic gauge/gravity duality comprise the original work presented here. We follow with summaries and discussions of the background material, the original work, and future investigations.

  14. Negative-Refraction Metamaterials: Fundamental Principles and Applications

    NASA Astrophysics Data System (ADS)

    Eleftheriades, G. V.; Balmain, K. G.

    2005-06-01

    Learn about the revolutionary new technology of negative-refraction metamaterials Negative-Refraction Metamaterials: Fundamental Principles and Applications introduces artificial materials that support the unusual electromagnetic property of negative refraction. Readers will discover several classes of negative-refraction materials along with their exciting, groundbreaking applications, such as lenses and antennas, imaging with super-resolution, microwave devices, dispersion-compensating interconnects, radar, and defense. The book begins with a chapter describing the fundamentals of isotropic metamaterials in which a negative index of refraction is defined. In the following chapters, the text builds on the fundamentals by describing a range of useful microwave devices and antennas. Next, a broad spectrum of exciting new research and emerging applications is examined, including: Theory and experiments behind a super-resolving, negative-refractive-index transmission-line lens 3-D transmission-line metamaterials with a negative refractive index Numerical simulation studies of negative refraction of Gaussian beams and associated focusing phenomena Unique advantages and theory of shaped lenses made of negative-refractive-index metamaterials A new type of transmission-line metamaterial that is anisotropic and supports the formation of sharp steerable beams (resonance cones) Implementations of negative-refraction metamaterials at optical frequencies Unusual propagation phenomena in metallic waveguides partially filled with negative-refractive-index metamaterials Metamaterials in which the refractive index and the underlying group velocity are both negative This work brings together the best minds in this cutting-edge field. It is fascinating reading for scientists, engineers, and graduate-level students in physics, chemistry, materials science, photonics, and electrical engineering.

  15. CZT Virtual Frisch-grid Detector: Principles and Applications

    SciTech Connect

    Cui,Y.; Bolotnikov, A.; Camarda, G.; Hossain, A.; James, R. B.

    2009-03-24

    Cadmium Zinc Telluride (CdZnTe or CZT) is a very attractive material for using as room-temperature semiconductor detectors, because it has a wide bandgap and a high atomic number. However, due to the material's poor hole mobility, several special techniques were developed to ensure its suitability for radiation detection. Among them, the virtual Frisch-grid CZT detector is an attractive option, having a simple configuration, yet delivering an outstanding spectral performance. The goal of our group in Brookhaven National Laboratory (BNL) is to improve the performance of Frisch-ring CZT detectors; most recently, that effort focused on the non-contacting Frisch-ring detector, allowing us to build an inexpensive, large-volume detector array with high energy-resolution and a large effective area. In this paper, the principles of virtual Frisch-grid detectors are described, especially BNL's innovative improvements. The potential applications of virtual Frisch-grid detectors are discussed, and as an example, a hand-held gamma-ray spectrometer using a CZT virtual Frischgrid detector array is introduced, which is a self-contained device with a radiation detector, readout circuit, communication circuit, and high-voltage supply. It has good energy resolution of 1.4% (FWHM of 662-keV peak) with a total detection volume of {approx}20 cm{sup 3}. Such a portable inexpensive device can be used widely in nonproliferation applications, non-destructive detection, radiation imaging, and for homeland security. Extended systems based on the same technology have potential applications in industrial- and nuclear-medical-imaging.

  16. A finite-state, finite-memory minimum principle, part 2

    NASA Technical Reports Server (NTRS)

    Sandell, N. R., Jr.; Athans, M.

    1975-01-01

    In part 1 of this paper, a minimum principle was found for the finite-state, finite-memory (FSFM) stochastic control problem. In part 2, conditions for the sufficiency of the minimum principle are stated in terms of the informational properties of the problem. This is accomplished by introducing the notion of a signaling strategy. Then a min-H algorithm based on the FSFM minimum principle is presented. This algorithm converges, after a finite number of steps, to a person - by - person extremal solution.

  17. Wideband Waveform Design principles for Solid-state Weather Radars

    SciTech Connect

    Bharadwaj, Nitin; Chandrasekar, V.

    2012-01-01

    The use of solid-state transmitter is becoming a key part of the strategy to realize a network of low cost electronically steered radars. However, solid-state transmitters have low peak powers and this necessitates the use of pulse compression waveforms. In this paper a frequency diversity wideband waveforms design is proposed to mitigate low sensitivity of solid-state transmitters. In addition, the waveforms mitigate the range eclipsing problem associated with long pulse compression. An analysis of the performance of pulse compression using mismatched compression filters designed to minimize side lobe levels is presented. The impact of range side lobe level on the retrieval of Doppler moments are presented. Realistic simulations are performed based on CSU-CHILL radar data and Center for Collaborative Adaptive Sensing of the Atmosphere (CASA) Integrated Project I (IP1) radar data.

  18. Polymer principles of protein calorimetric two-state cooperativity.

    PubMed

    Kaya, H; Chan, H S

    2000-09-01

    The experimental calorimetric two-state criterion requires the van't Hoff enthalpy DeltaH(vH) around the folding/unfolding transition midpoint to be equal or very close to the calorimetric enthalpy DeltaH(cal) of the entire transition. We use an analytical model with experimental parameters from chymotrypsin inhibitor 2 to elucidate the relationship among several different van't Hoff enthalpies used in calorimetric analyses. Under reasonable assumptions, the implications of these DeltaH(vH)'s being approximately equal to DeltaH(cal) are equivalent: Enthalpic variations among denatured conformations in real proteins are much narrower than some previous lattice-model estimates, suggesting that the energy landscape theory "folding to glass transition temperature ratio" T(f) /T(g) may exceed 6.0 for real calorimetrically two-state proteins. Several popular three-dimensional lattice protein models, with different numbers of residue types in their alphabets, are found to fall short of the high experimental standard for being calorimetrically two-state. Some models postulate a multiple-conformation native state with substantial pre-denaturational energetic fluctuations well below the unfolding transition temperature, or predict a significant post-denaturational continuous conformational expansion of the denatured ensemble at temperatures well above the transition point, or both. These scenarios either disagree with experiments on protein size and dynamics, or are inconsistent with conventional interpretation of calorimetric data. However, when empirical linear baseline subtractions are employed, the resulting DeltaH(vH)/DeltaH(cal)'s for some models can be increased to values closer to unity, and baseline subtractions are found to correspond roughly to an operational definition of native-state conformational diversity. These results necessitate a re-assessment of theoretical models and experimental interpretations.

  19. Physical principles and current status of emerging non-volatile solid state memories

    NASA Astrophysics Data System (ADS)

    Wang, L.; Yang, C.-H.; Wen, J.

    2015-07-01

    Today the influence of non-volatile solid-state memories on persons' lives has become more prominent because of their non-volatility, low data latency, and high robustness. As a pioneering technology that is representative of non-volatile solidstate memories, flash memory has recently seen widespread application in many areas ranging from electronic appliances, such as cell phones and digital cameras, to external storage devices such as universal serial bus (USB) memory. Moreover, owing to its large storage capacity, it is expected that in the near future, flash memory will replace hard-disk drives as a dominant technology in the mass storage market, especially because of recently emerging solid-state drives. However, the rapid growth of the global digital data has led to the need for flash memories to have larger storage capacity, thus requiring a further downscaling of the cell size. Such a miniaturization is expected to be extremely difficult because of the well-known scaling limit of flash memories. It is therefore necessary to either explore innovative technologies that can extend the areal density of flash memories beyond the scaling limits, or to vigorously develop alternative non-volatile solid-state memories including ferroelectric random-access memory, magnetoresistive random-access memory, phase-change random-access memory, and resistive random-access memory. In this paper, we review the physical principles of flash memories and their technical challenges that affect our ability to enhance the storage capacity. We then present a detailed discussion of novel technologies that can extend the storage density of flash memories beyond the commonly accepted limits. In each case, we subsequently discuss the physical principles of these new types of non-volatile solid-state memories as well as their respective merits and weakness when utilized for data storage applications. Finally, we predict the future prospects for the aforementioned solid-state memories for

  20. The application of psychoanalytic principles to the study of "magic".

    PubMed

    Rudan, Vlasta; Tripković, Mara; Vidas, Mercedes

    2003-06-01

    In this paper Freud's work on animism and magic is elaborated. Those two subjects are presented mainly in his work "Totem and Taboo" (1913). The true motives, which lead primitive man to practice magic are, according to Freud, human whishes and his immense belief in their power. Importance attached to wishes and to the will has been extended from them to all those psychical acts, which are subjected to will. A general overvaluation has thus come about of all mental processes. Things become less important than ideas of things. Relations, which hold between the ideas of things, are equally hold between the things. The principle of governing magic or the technique of animistic way of thinking is one of the 'omnipotence of thoughts'. The overvaluation of psychic acts could be brought into relation with narcissism and megalomania, a belief in the thaumaturgic force of words and a technique for dealing with the external world--'magic'--which appears to be a logical application of these grandiose premises. Recent psychoanalytic authors dealing with the problem of magic emphasize that magic survived culturally to the present days and even in adults who are otherwise intellectually and scientifically 'modern'. Their explanations for that derive from Ferenczi's and especially Róheim's work that pointed out that magic facilitates adaptive and realistically effective endeavors. Balter pointed out that magic employs ego functioning, and conversely ego functioning includes magic.

  1. Applications of Principled Search Methods in Climate Influences and Mechanisms

    NASA Technical Reports Server (NTRS)

    Glymour, Clark

    2005-01-01

    Forest and grass fires cause economic losses in the billions of dollars in the U.S. alone. In addition, boreal forests constitute a large carbon store; it has been estimated that, were no burning to occur, an additional 7 gigatons of carbon would be sequestered in boreal soils each century. Effective wildfire suppression requires anticipation of locales and times for which wildfire is most probable, preferably with a two to four week forecast, so that limited resources can be efficiently deployed. The United States Forest Service (USFS), and other experts and agencies have developed several measures of fire risk combining physical principles and expert judgment, and have used them in automated procedures for forecasting fire risk. Forecasting accuracies for some fire risk indices in combination with climate and other variables have been estimated for specific locations, with the value of fire risk index variables assessed by their statistical significance in regressions. In other cases, the MAPSS forecasts [23, 241 for example, forecasting accuracy has been estimated only by simulated data. We describe alternative forecasting methods that predict fire probability by locale and time using statistical or machine learning procedures trained on historical data, and we give comparative assessments of their forecasting accuracy for one fire season year, April- October, 2003, for all U.S. Forest Service lands. Aside from providing an accuracy baseline for other forecasting methods, the results illustrate the interdependence between the statistical significance of prediction variables and the forecasting method used.

  2. Maximum entropy principle for stationary states underpinned by stochastic thermodynamics

    NASA Astrophysics Data System (ADS)

    Ford, Ian J.

    2015-11-01

    The selection of an equilibrium state by maximizing the entropy of a system, subject to certain constraints, is often powerfully motivated as an exercise in logical inference, a procedure where conclusions are reached on the basis of incomplete information. But such a framework can be more compelling if it is underpinned by dynamical arguments, and we show how this can be provided by stochastic thermodynamics, where an explicit link is made between the production of entropy and the stochastic dynamics of a system coupled to an environment. The separation of entropy production into three components allows us to select a stationary state by maximizing the change, averaged over all realizations of the motion, in the principal relaxational or nonadiabatic component, equivalent to requiring that this contribution to the entropy production should become time independent for all realizations. We show that this recovers the usual equilibrium probability density function (pdf) for a conservative system in an isothermal environment, as well as the stationary nonequilibrium pdf for a particle confined to a potential under nonisothermal conditions, and a particle subject to a constant nonconservative force under isothermal conditions. The two remaining components of entropy production account for a recently discussed thermodynamic anomaly between over- and underdamped treatments of the dynamics in the nonisothermal stationary state.

  3. Application of the principle of similarity fluid mechanics

    NASA Technical Reports Server (NTRS)

    Hendericks, R. C.; Sengers, J. V.

    1979-01-01

    The principle of similarity applied to fluid mechanics is described and illustrated. The concept of transforming the conservation equations by combining similarity principles for thermophysical properties with those for fluid flow is examined. The usefulness of the procedure is illustrated by applying such a transformation to calculate two phase critical mass flow through a nozzle.

  4. Application of the double-contingency principle within BNFL

    SciTech Connect

    Strafford, P.I.D.

    1995-12-31

    Historically, the double-contingency principle has been used for criticality assessment within British Nuclear Fuels plc (BNFL). This paper outlines what is understood by the double-contingency principle to illustrate how it is applied in criticality safety assessments and to highlight various problem areas that are encountered and, where possible, how they might be solved.

  5. Continuing Health Professional Education: Principles for Global Application.

    ERIC Educational Resources Information Center

    Woolf, Colin R.

    1993-01-01

    Offers a list of continuing health professional education principles developed by a network of 26 individuals in 14 countries that provide a broad perspective and, as a result of this consultation with individuals of varying cultural circumstances, show differences in emphasis. Proposes personal, educational, and administrative principles.…

  6. Fist Principles Approach to the Magneto Caloric Effect: Application to Ni2MnGa

    NASA Astrophysics Data System (ADS)

    Odbadrakh, Khorgolkhuu; Nicholson, Don; Rusanu, Aurelian; Eisenbach, Markus; Brown, Gregory; Evans, Boyd, III

    2011-03-01

    The magneto-caloric effect (MCE) has potential application in heating and cooling technologies. In this work, we present calculated magnetic structure of a candidate MCE material, Ni 2 MnGa. The magnetic configurations of a 144 atom supercell is first explored using first-principle, the results are then used to fit exchange parameters of a Heisenberg Hamiltonian. The Wang-Landau method is used to calculate the magnetic density of states of the Heisenberg Hamiltonian. Based on this classical estimate, the magnetic density of states is calculated using the Wang Landau method with energies obtained from the first principles method. The Currie temperature and other thermodynamic properties are calculated using the density of states. The relationships between the density of magnetic states and the field induced adiabatic temperature change and isothermal entropy change are discussed. This work was sponsored by the Laboratory Directed Research and Development Program (ORNL), by the Mathematical, Information, and Computational Sciences Division; Office of Advanced Scientific Computing Research (US DOE), and by the Materials Sciences and Engineering Division; Office of Basic Energy Sciences (US DOE).

  7. 17 CFR Appendix A to Part 39 - Application Guidance and Compliance With Core Principles

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... compliance with one or more core principles. Core Principle B: FINANCIAL RESOURCES—The applicant shall demonstrate that the applicant has adequate financial, operational, and managerial resources to discharge the... derivatives clearing organizations may describe or otherwise document: 1. The resources dedicated...

  8. 28 CFR 552.22 - Principles governing the use of force and application of restraints.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Principles governing the use of force and... JUSTICE INSTITUTIONAL MANAGEMENT CUSTODY Use of Force and Application of Restraints on Inmates § 552.22 Principles governing the use of force and application of restraints. (a) Staff ordinarily shall first...

  9. 29 CFR 1620.19 - Equality of wages-application of the principle.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 4 2011-07-01 2011-07-01 false Equality of wages-application of the principle. 1620.19 Section 1620.19 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION THE EQUAL PAY ACT § 1620.19 Equality of wages—application of the principle. Equal wages must be...

  10. 29 CFR 1620.19 - Equality of wages-application of the principle.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 4 2012-07-01 2012-07-01 false Equality of wages-application of the principle. 1620.19 Section 1620.19 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION THE EQUAL PAY ACT § 1620.19 Equality of wages—application of the principle. Equal wages must be...

  11. 29 CFR 1620.19 - Equality of wages-application of the principle.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 4 2013-07-01 2013-07-01 false Equality of wages-application of the principle. 1620.19 Section 1620.19 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION THE EQUAL PAY ACT § 1620.19 Equality of wages—application of the principle. Equal wages must be...

  12. 29 CFR 1620.19 - Equality of wages-application of the principle.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Equality of wages-application of the principle. 1620.19 Section 1620.19 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION THE EQUAL PAY ACT § 1620.19 Equality of wages—application of the principle. Equal wages must be...

  13. 29 CFR 1620.19 - Equality of wages-application of the principle.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 4 2014-07-01 2014-07-01 false Equality of wages-application of the principle. 1620.19 Section 1620.19 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION THE EQUAL PAY ACT § 1620.19 Equality of wages—application of the principle. Equal wages must be...

  14. Optimal quantum state estimation with use of the no-signaling principle

    SciTech Connect

    Han, Yeong-Deok; Bae, Joonwoo; Wang Xiangbin; Hwang, Won-Young

    2010-12-15

    A simple derivation of the optimal state estimation of a quantum bit was obtained by using the no-signaling principle. In particular, the no-signaling principle determines a unique form of the guessing probability independent of figures of merit, such as the fidelity or information gain. This proves that the optimal estimation for a quantum bit can be achieved by the same measurement for almost all figures of merit.

  15. Principles and application of shock-tubes and shock tunnels

    NASA Technical Reports Server (NTRS)

    Ried, R. C.; Clauss, H. G., Jr.

    1963-01-01

    The principles, theoretical flow equations, calculation techniques, limitations and practical performance characteristics of basic and high performance shock tubes and shock tunnels are presented. Selected operating curves are included.

  16. Mixing light and matter waves: Principles and applications

    NASA Astrophysics Data System (ADS)

    Huang, Yuping

    The work of this dissertation is committed to theoretically explore rich physics involving quantum-mechanical mixing of light and matter waves, while specifically seeking applications in the fields of quantum interferometry, quantum information processing, and testing fundamental quantum mechanics. Towards this goal, the present research is guided by two lines. The first line is to study and manipulate collective behaviors of multi-atom systems at quantum-degenerate temperature, where the wave nature of atoms is maximized. Specifically, a variety of phase-coherent mixing processes of two macroscopic matter-waves, in the form of gaseous Bose-Einstein condensate (BEC), are investigated and engineered via (i) tuning atomic collisional interaction and/or inter-wave tunneling rate; (ii) mixing with optical waves of phase-locked lasers. By these means, a series of novel applications are proposed for generating highly nonclassical states, Heisenberg-uncertainty phase measurements and ultra-fast quantum state mapping between light and matter waves. The second line is to coherently mix single atoms with light beams in free space. It is well known that the free-space atom-photon interactions are weak, usually dominated by incoherent dissipation via spontaneous emission. Usable couplings between atoms and photons are routinely realized by confining them in high-finesse optical cavities in the strong coupling regime. The goal of the present work is to use ultrahigh-sensitivity quantum interferometry and the quantum Zeno effect to overcome the weak free-space atom-photon coupling, thus leading to implementations of quantum information processing in free space. Along the first line of this dissertation, chapter II describes a dynamical approach to create many-particle Schrodinger cat states, created in a Bose-Einstein condensate trapped in a double-well potential, via the technique of Feshbach resonance. A detection scheme for cat states is proposed via revivial of the initial

  17. Status in calculating electronic excited states in transition metal oxides from first principles.

    PubMed

    Bendavid, Leah Isseroff; Carter, Emily Ann

    2014-01-01

    Characterization of excitations in transition metal oxides is a crucial step in the development of these materials for photonic and optoelectronic applications. However, many transition metal oxides are considered to be strongly correlated materials, and their complex electronic structure is challenging to model with many established quantum mechanical techniques. We review state-of-the-art first-principles methods to calculate charged and neutral excited states in extended materials, and discuss their application to transition metal oxides. We briefly discuss developments in density functional theory (DFT) to calculate fundamental band gaps, and introduce time-dependent DFT, which can model neutral excitations. Charged excitations can be described within the framework of many-body perturbation theory based on Green's functions techniques, which predominantly employs the GW approximation to the self-energy to facilitate a feasible solution to the quasiparticle equations. We review the various implementations of the GW approximation and evaluate each approach in its calculation of fundamental band gaps of many transition metal oxides. We also briefly review the related Bethe-Salpeter equation (BSE), which introduces an electron-hole interaction between GW-derived quasiparticles to describe accurately neutral excitations. Embedded correlated wavefunction theory is another framework used to model localized neutral or charged excitations in extended materials. Here, the electronic structure of a small cluster is modeled within correlated wavefunction theory, while its coupling to its environment is represented by an embedding potential. We review a number of techniques to represent this background potential, including electrostatic representations and electron density-based methods, and evaluate their application to transition metal oxides.

  18. Main principles of radiation protection and their applications in waste management

    SciTech Connect

    Devgun, J.S.

    1993-09-01

    The average exposure for an individual from such background in the United States is about 300 mrem per year with approximately 200 mrem of this coming from radon exposure alone. In addition to the natural sources of background radiation, a very small amount of the background radiation occurs due to the nuclear weapons test fallout. Manmade sources of radiation also include certain consumer products, industrial and research use of radioisotopes, medical X-rays, and radiopharmaceuticals. When all sources, natural and man-made, are taken into account, the National Council on Radiation Protection and Measurements (NCRP) has estimated that the average annual dose to individuals in the US population is 360 mrem (NCRP Report No. 93). In this report the fundamental principles of radiation protection are reviewed, as well as the relevant laws and regulations in the United States and discuss application of radiation protection in radioactive waste management.

  19. Principles and applications of electro-spark deposition

    SciTech Connect

    Johnson, R.N.

    1987-12-01

    Electro-spark deposition (ESD) is a pulsed-arc micro-welding process using short-duration, high-current electrical pulsed to deposit an electrode material on a metallic substrate. It is one of the few methods available by which a fused, metallurgically bonded coating can be applied with such a low total heat input that the bulk substrate material remains at or near ambient temperatures. The short duration of the electrical pulse allows an extremely rapid solidification of the deposited material and results in an exceptionally fine-grained, homogeneous coating that approaches an amorphous structure. This structure is believed to contribute to the good tribological and corrosion performance observed for hardsurfacing materials used in demanding environments. A brief historical review of the process is provided, followed by descriptions of the present state-of-the-art, of the performance and applications of electro-spark deposition coatings in nuclear and fossil energy environments, and of potential applications in development. 23 refs., 23 figs., 3 tabs.

  20. Principles and applications of fluorescence lifetime correlation spectroscopy

    NASA Astrophysics Data System (ADS)

    Beranová, Lenka; Humpolícková, Jana; Hof, Martin

    2009-05-01

    Two fluorescence spectroscopy concepts, fluorescence correlation spectroscopy and time correlated single photon counting (TCSPC) are employed in fluorescence lifetime correlation spectroscopy (FLCS) - a relatively new technique with several experimental benefits. In FLCS experiments, pulsed excitation is used and data are stored in a special time-tagged time-resolved mode. Mathematical treatment of TCSPC decay patterns of distinct fluorophores and their mixture enables to calculate autocorrelation functions of each of the fluorophores and thus their diffusion properties and concentrations can be determined separately. Moreover, crosscorrelation of the two signals can be performed and information on interaction of the species can be obtained. This technique is particularly helpful for distinguishing different states of the same fluorophore in different microenvironments. The first application of that concept represents the simultaneous determination of two-dimensional diffusion in planar lipid layers and three-dimensional vesicle diffusion in bulk above the lipid layers. The lifetime in both investigated systems differed because the lifetime of the dye is considerably quenched in the layer near the light-absorbing surface. This concept was also used in other applications: a) investigation of a conformational change of a labeled protein, b) detection of small amounts of labeled oligonucleotides bound to metal particles or c) elucidation of the compaction mechanism of different sized labeled DNA molecules. Moreover, it was demonstrated that FLCS can help to overcome some FCS experimental drawbacks.

  1. Reconstruction of motional states of neutral atoms via maximum entropy principle

    NASA Astrophysics Data System (ADS)

    Drobný, Gabriel; Bužek, Vladimír

    2002-05-01

    We present a scheme for a reconstruction of states of quantum systems from incomplete tomographiclike data. The proposed scheme is based on the Jaynes principle of maximum entropy. We apply our algorithm for a reconstruction of motional quantum states of neutral atoms. As an example we analyze the experimental data obtained by Salomon and co-workers and we reconstruct Wigner functions of motional quantum states of Cs atoms trapped in an optical lattice.

  2. The 'Herbivory Uncertainty Principle': application in a cerrado site.

    PubMed

    Gadotti, C A; Batalha, M A

    2010-05-01

    Researchers may alter the ecology of their studied organisms, even carrying out apparently beneficial activities, as in herbivory studies, when they may alter herbivory damage. We tested whether visit frequency altered herbivory damage, as predicted by the 'Herbivory Uncertainty Principle'. In a cerrado site, we established 80 quadrats, in which we sampled all woody individuals. We used four visit frequencies (high, medium, low, and control), quantifying, at the end of three months, herbivory damage for each species in each treatment. We did not corroborate the 'Herbivory Uncertainty Principle', since visiting frequency did not alter herbivory damage, at least when the whole plant community was taken into account. However, when we analysed each species separately, four out of 11 species presented significant differences in herbivory damage, suggesting that the researcher is not independent of its measurements. The principle could be tested in other ecological studies in which it may occur, such as those on animal behaviour, human ecology, population dynamics, and conservation.

  3. The application of design principles to innovate clinical care delivery.

    PubMed

    Brennan, Michael D; Duncan, Alan K; Armbruster, Ryan R; Montori, Victor M; Feyereisn, Wayne L; LaRusso, Nicholas F

    2009-01-01

    Clinical research centers that support hypothesis-driven investigation have long been a feature of academic medical centers but facilities in which clinical care delivery can be systematically assessed and evaluated have heretofore been nonexistent. The Institute of Medicine report "Crossing the Quality Chasm" identified six core attributes of an ideal care delivery system that in turn relied heavily on system redesign. Although manufacturing and service industries have leveraged modern design principles in new product development, healthcare has lagged behind. In this article, we describe a methodology utilized by our facility to study the clinical care delivery system that incorporates modern design principles.

  4. Application of the MHD energy principle to magnetostatic atmospheres

    SciTech Connect

    Zweibel, E.G.

    1984-11-01

    We apply the MHD energy principle to the stability of a magnetized atmosphere which is bounded below by much denser fluid, as is the solar corona. We treat the two fluids as ideal; the approximation which is consistent with the energy principle, and use the dynamical conditions that must hold at a fluid-fluid interface to show that if vertical displacements of the lower boundary are permitted, then the lower atmosphere must be perturbed as well. However, displacements which do not perturb the coronal boundary can be properly treated as isolated perturbations of the corona alone.

  5. Application of the MHD energy principle to magnetostatic atmospheres

    NASA Technical Reports Server (NTRS)

    Zweibel, E. G.

    1984-01-01

    The MHD energy principle is applied to the stability of a magnetized atmosphere which is bounded below by much denser fluid, as is the solar corona. The two fluids are treated as ideal; the approximation is consistent with the energy principle, and the dynamical conditions that must hold at a fluid-fluid interface are used to show that if vertical displacements of the lower boundary are premitted, then the lower atmosphere must be perturbed as well. However, displacements which do not perturb the coronal boundary can be properly treated as isolated perturbations of the corona alone.

  6. High resolution solar observations from first principles to applications

    NASA Astrophysics Data System (ADS)

    Verdoni, Angelo P.

    2009-10-01

    The expression "high-resolution observations" in Solar Physics refers to the spatial, temporal and spectral domains in their entirety. High-resolution observations of solar fine structure are a necessity to answer many of the intriguing questions related to solar activity. However, a researcher building instruments for high-resolution observations has to cope with the fact that these three domains often have diametrically opposed boundary conditions. Many factors have to be considered in the design of a successful instrument. Modern post-focus instruments are more closely linked with the solar telescopes that they serve than in past. In principle, the quest for high-resolution observations already starts with the selection of the observatory site. The site survey of the Advanced Technology Solar Telescope (ATST) under the stewardship of the National Solar Observatory (NSO) has identified Big Bear Solar Observatory (BBSO) as one of the best sites for solar observations. In a first step, the seeing characteristics at BBSO based on the data collected for the ATST site survey are described. The analysis will aid in the scheduling of high-resolution observations at BBSO as well as provide useful information concerning the design and implementation of a thermal control system for the New Solar Telescope (NST). NST is an off-axis open-structure Gregorian-style telescope with a 1.6 m aperture. NST will be housed in a newly constructed 5/8-sphere ventilated dome. With optics exposed to the surrounding air, NST's open-structure design makes it particularly vulnerable to the effects of enclosure-related seeing. In an effort to mitigate these effects, the initial design of a thermal control system for the NST dome is presented. The goal is to remediate thermal related seeing effects present within the dome interior. The THermal Control System (THCS) is an essential component for the open-telescope design of NST to work. Following these tasks, a calibration routine for the

  7. Slope across the Curriculum: Principles and Standards for School Mathematics and Common Core State Standards

    ERIC Educational Resources Information Center

    Nagle, Courtney; Moore-Russo, Deborah

    2014-01-01

    This article provides an initial comparison of the Principles and Standards for School Mathematics and the Common Core State Standards for Mathematics by examining the fundamental notion of slope. Each set of standards is analyzed using eleven previously identified conceptualizations of slope. Both sets of standards emphasize Functional Property,…

  8. Relationships among Teacher's Knowledge and Application of Principles of Adult Teaching and Student Satisfaction. Final Report.

    ERIC Educational Resources Information Center

    Berg, Clay N., Jr.

    The nature of the relationship between a teacher's knowledge of certain principles of adult teaching, his application of those principles in classroom practice, and the resultant level of satisfaction reported by his adult students was studied. Agroup of 1,596 adults in 100 university classes were the subjects. A theoretical framework adapted from…

  9. 10 CFR 603.625 - Cost principles or standards applicable to for-profit participants.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Accounting Principles (see Statement of Financial Accounting Standards Number 2, “Accounting for Research and... INVESTMENT AGREEMENTS Award Terms Affecting Participants' Financial, Property, and Purchasing Systems Financial Matters § 603.625 Cost principles or standards applicable to for-profit participants. (a) So...

  10. 10 CFR 603.625 - Cost principles or standards applicable to for-profit participants.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Accounting Principles (see Statement of Financial Accounting Standards Number 2, “Accounting for Research and... INVESTMENT AGREEMENTS Award Terms Affecting Participants' Financial, Property, and Purchasing Systems Financial Matters § 603.625 Cost principles or standards applicable to for-profit participants. (a) So...

  11. A maximum principle for smooth optimal impulsive control problems with multipoint state constraints

    NASA Astrophysics Data System (ADS)

    Dykhta, V. A.; Samsonyuk, O. N.

    2009-06-01

    A nonlinear optimal impulsive control problem with trajectories of bounded variation subject to intermediate state constraints at a finite number on nonfixed instants of time is considered. Features of this problem are discussed from the viewpoint of the extension of the classical optimal control problem with the corresponding state constraints. A necessary optimality condition is formulated in the form of a smooth maximum principle; thorough comments are given, a short proof is presented, and examples are discussed.

  12. An application of Hamiltonian neurodynamics using Pontryagin's Maximum (Minimum) Principle.

    PubMed

    Koshizen, T; Fulcher, J

    1995-12-01

    Classical optimal control methods, notably Pontryagin's Maximum (Minimum) Principle (PMP) can be employed, together with Hamiltonians, to determine optimal system weights in Artificial Neural dynamical systems. A new learning rule based on weight equations derived using PMP is shown to be suitable for both discrete- and continuous-time systems, and moreover, can also be applied to feedback networks. Preliminary testing shows that this PMP learning rule compares favorably with Standard BackPropagations (SBP) on the XOR problem.

  13. Shock Hugoniots of molecular liquids and the principle of corresponding states

    SciTech Connect

    Chisolm, Eric D; Crockett, Scott D; Shaw, Milton S

    2009-01-01

    We observe that the shock velocity-particle velocity Hugoniots for various liquids (e.g. nitrogen, oxygen, carbon dioxide, argon) lie almost on top of one another. Recalling the work of Ross and Ree [J. Chem. Phys. 73, 6146-6152 (1980)], we hypothesize that these materials obey a principle of corresponding states. We use the principle to deduce how the Hugoniots of two corresponding materials should be related, and we compare the results with data and find good agreement. We suggest this as a method for estimating the Hugoniot of a material of the appropriate type in the absence of shock data, and we illustrate with fluorine.

  14. Squeezed States, Uncertainty Relations and the Pauli Principle in Composite and Cosmological Models

    NASA Technical Reports Server (NTRS)

    Terazawa, Hidezumi

    1996-01-01

    The importance of not only uncertainty relations but also the Pauli exclusion principle is emphasized in discussing various 'squeezed states' existing in the universe. The contents of this paper include: (1) Introduction; (2) Nuclear Physics in the Quark-Shell Model; (3) Hadron Physics in the Standard Quark-Gluon Model; (4) Quark-Lepton-Gauge-Boson Physics in Composite Models; (5) Astrophysics and Space-Time Physics in Cosmological Models; and (6) Conclusion. Also, not only the possible breakdown of (or deviation from) uncertainty relations but also the superficial violation of the Pauli principle at short distances (or high energies) in composite (and string) models is discussed in some detail.

  15. Diffusion Tensor Imaging and Its Application to Traumatic Brain Injury: Basic Principles and Recent Advances

    DTIC Science & Technology

    2012-12-01

    Diffusion Tensor Imaging and Its Application to Traumatic Brain Injury: Basic Principles and Recent Advances Ping-Hong Yeh1*, Terrence R. Oakes2,3...00-2012 4. TITLE AND SUBTITLE Diffusion Tensor Imaging and Its Application to Traumatic Brain Injury: Basic Principles and Recent Advances 5a...Gerard Riedy1,2,3,4 1Traumatic Brain Injury Image Analysis Lab, Henry Jackson Foundation for the Advancement of Military Medicine, Rockville, USA

  16. Equation of state for technetium from X-ray diffraction and first-principle calculations

    NASA Astrophysics Data System (ADS)

    Mast, Daniel S.; Kim, Eunja; Siska, Emily M.; Poineau, Frederic; Czerwinski, Kenneth R.; Lavina, Barbara; Forster, Paul M.

    2016-08-01

    The ambient temperature equation of state (EoS) of technetium metal has been measured by X-ray diffraction. The metal was compressed using a diamond anvil cell and using a 4:1 methanol-ethanol pressure transmitting medium. The maximum pressure achieved, as determined from the gold pressureEquation of state for technetium from X-ray diffraction and first-principle calculations scale, was 67 GPa. The compression data shows that the HCP phase of technetium is stable up to 67 GPa. The compression curve of technetium was also calculated using first-principles total-energy calculations. Utilizing a number of fitting strategies to compare the experimental and theoretical data it is determined that the Vinet equation of state with an ambient isothermal bulk modulus of B0T=288 GPa and a first pressure derivative of B‧=5.9(2) best represent the compression behavior of technetium metal.

  17. Principles and Applications of Surgical Oncology in Exotic Animals.

    PubMed

    Steffey, Michele A

    2017-01-01

    The diagnosis and treatment of cancer in exotic species is a rapidly evolving area of veterinary medicine. In general, surgical excision remains pivotal in cancer treatment, although optimal outcomes are achieved when a coherent and thorough diagnostic and therapeutic plan is created prior to surgery. While surgical cure is not always achieveable, multimodal treatment plans can offer a variety of options, and palliative procedures may be used to improve quality of life. Treatment goals, whether curative intent or palliative intent, should be identified before surgery, and practitioners should endeavor to adhere to surgical principles in order to attain the best outcomes.

  18. Dry tests: construction, principle of action, and application

    NASA Astrophysics Data System (ADS)

    Chwojnowski, Andrzej

    2001-08-01

    A short description of dry test constructions, chemical principles of action are presented. An example of statement of reflection spectra of described dry tests were shown. For this spectra the best region for determination of analytes by reflectance were selected. The results of a few examples of determination pollution in water an din milk were shown. The all determination had been carried out by dry tests. The reading was performed by comparison with a color scale. In case of flood water analysis determination had been carried out by comparison with a color scale, reflectometrically and by means of classic colorimetric methods.

  19. Principles of pharmacodynamics and their applications in veterinary pharmacology.

    PubMed

    Lees, P; Cunningham, F M; Elliott, J

    2004-12-01

    instance at molecular, cellular and tissue levels in vitro, so that the primary effects can be better understood without interference from the complexities involved in whole animal studies. When a drug, hormone or neurotransmitter combines with a target molecule, it is described as a ligand. Ligands are classified into two groups, agonists (which initiate a chain of reactions leading, usually via the release or formation of secondary messengers, to the response) and antagonists (which fail to initiate the transduction pathways but nevertheless compete with agonists for occupancy of receptor sites and thereby inhibit their actions). The parameters which characterize drug receptor interaction are affinity, efficacy, potency and sensitivity, each of which can be elucidated quantitatively for a particular drug acting on a particular receptor in a particular tissue. The most fundamental objective of PDs is to use the derived numerical values for these parameters to classify and sub-classify receptors and to compare and classify drugs on the basis of their affinity, efficacy, potency and sensitivity. This review introduces and summarizes the principles of PDs and illustrates them with examples drawn from both basic and veterinary pharmacology. Drugs acting on adrenoceptors and cardiovascular, non-steroidal anti-inflammatory and antimicrobial drugs are considered briefly to provide a foundation for subsequent reviews in this issue which deal with pharmacokinetic (PK)-PD modelling and integration of these drug classes. Drug action on receptors has many features in common with enzyme kinetics and gas adsorption onto surfaces, as defined by Michaelis-Menten and Langmuir absorption equations, respectively. These and other derived equations are outlined in this review. There is, however, no single theory which adequately explains all aspects of drug-receptor interaction. The early 'occupation' and 'rate' theories each explain some, but not all, experimental observations. From these

  20. State Financial Aid: Applying Redesign Principles through State Engagement. Special Report

    ERIC Educational Resources Information Center

    Pingel, Sarah

    2016-01-01

    College is increasingly expensive for students, but states have an important policy tool to help defray the costs: state financial aid programs. However, many states' programs are misaligned with articulated strategic postsecondary education policy goals. Over the past two years, Education Commission of the States has supported a variety of…

  1. Application of the locality principle to radio occultation studies of the Earth's atmosphere and ionosphere

    NASA Astrophysics Data System (ADS)

    Pavelyev, A. G.; Liou, Y. A.; Matyugov, S. S.; Pavelyev, A. A.; Gubenko, V. N.; Zhang, K.; Kuleshov, Y.

    2015-07-01

    A new formulation of the previously introduced principle of locality is presented. The principle can be applied for modernization of the radio occultation (RO) remote sensing of the atmospheres and ionospheres of the Earth and other planets. The principle states that significant contributions to variations of the intensity and phase of the radio waves passing through a layered medium are connected with influence of the vicinities of tangential points where the refractivity gradient is perpendicular to the radio ray trajectory. The RO method assumes spherical symmetry of the investigated medium. In this case, if location of a tangent point relative to the spherical symmetry centre is known, the time derivatives of the RO signal phase and Doppler frequency variations can be recalculated into the refractive attenuation. Several important findings are consequences of the locality principle: (i) if position of the centre of symmetry is known, the total absorption along the ray path can be determined at a single frequency; (ii) in the case of low absorption the height, displacement from the radio ray perigee, and tilt of the inclined ionospheric (atmospheric) layers can be evaluated; (iii) the contributions of the layered and irregular structures in the RO signal can be separated and parameters of layers and turbulence can be measured at a single frequency using joint analysis of the intensity and phase variations. Specially for the Earth's troposphere, the altitude distributions of the weak total absorption (about of 1-4 db) of the radio waves at GPS frequencies corresponding to possible influence of the oxygen, water vapour, and hydrometeors can be measured with accuracy of about 0.1 db at a single frequency. In accordance with the locality principle, a new index of ionospheric activity is introduced. This index is measured from the phase variations of radio waves passing through the ionosphere. Its high correlation with the S4 scintillation index is established. This

  2. Application of locality principle to radio occultation studies of the Earth's atmosphere and ionosphere

    NASA Astrophysics Data System (ADS)

    Pavelyev, A. G.; Liou, Y. A.; Matyugov, S. S.; Pavelyev, A. A.; Gubenko, V. N.; Zhang, K.; Kuleshov, Y.

    2015-01-01

    A new formulation of previously introduced principle of locality is presented. The principle can be applied for modernization of the radio occultation (RO) remote sensing of the atmospheres and ionospheres of the Earth and planets. The principle states that significant contributions to variations of the amplitude and phase of the radio waves passing through a layered medium are connected with influence of the vicinities of tangential points where the refractivity gradient is perpendicular to the radio ray trajectory. The RO method assumes spherical symmetry of the investigated medium. In this case if location of a tangent point relative to the spherical symmetry center is known, the derivatives on time of the RO signal phase and Doppler frequency variations can be recalculated into the refractive attenuation. Several important findings are consequences of the locality principle: (i) if position of the center of symmetry is known, the total absorption along the ray path can be determined at a single frequency, (ii) in the case of low absorption the height, displacement from the radio ray perigee, and tilt of the inclined ionospheric (atmospheric) layers can be evaluated, (iii) the contributions of the layered and irregular structures in the RO signal can be separated and parameters of layers and turbulence can be measured at a single frequency using joint analysis of the amplitude and phase variations. Specially for the Earth's troposphere, the altitude distributions of the weak total absorption (about of 1-4 db) of the radio waves at GPS frequencies corresponding to possible influence of the oxygen and water vapor can be measured with accuracy of about 0.1 db at a single frequency. According with the locality principle, a new index of ionospheric activity is introduced. This index is measured from the phase variations of radio waves passing through the ionosphere. Its high correlation with S4 scintillation index is established. This correlation indicates the

  3. The Space Thermal Signature Model: Principles And Applications

    NASA Astrophysics Data System (ADS)

    D'Agostino, John A.

    1987-09-01

    The SPACE (Sun, Precipitation, Atmosphere, Clouds, Earth) Thermal Signature Model has been developed by XonTech as a tool to be used in the accurate prediction of military thermal signatures. Currently this model has been optimized to address 8-12 micrometer signatures of armored ground targets in natural background settings. With somewhat lesser accuracy the current model design can address the 3-5 micrometer spectral region. With some model modifications, air and space targets could be addressed. The model is based entirely on first principles with respect to the thermal signature components induced by the natural environment. However, self-heating effects such as those caused by a tank engine or by friction require empirical input data which must be derived from pre-existing thermal measurements. The SPACE model has been programmed in compiled Microsoft BASIC to run on PC-compatible computers. Some generic target and background descriptions are part of the model ensemble. The development of additional descriptive data bases to cover specific target/background scenarios is possible using related utility software which has been developed for this purpose. The SPACE model is currently being used both by Government and industry to support model comparison studies, the prediction of target-to-background thermal contrast signatures, and the generation of synthetic infrared thermal imagery. It is the purpose of this paper to provide a brief tutorial on the modeling principles behind SPACE, a description of the SPACE software architecture and operation, and some example problems.

  4. First-principles molecular dynamics calculations of the equation of state for tantalum.

    PubMed

    Ono, Shigeaki

    2009-11-20

    The equation of state of tantalum (Ta) has been investigated to 100 GPa and 3,000 K using the first-principles molecular dynamics method. A large volume dependence of the thermal pressure of Ta was revealed from the analysis of our data. A significant temperature dependence of the calculated effective Grüneisen parameters was confirmed at high pressures. This indicates that the conventional approach to analyze thermal properties using the Mie-Grüneisen approximation is likely to have a significant uncertainty in determining the equation of state for Ta, and that an intrinsic anharmonicity should be considered to analyze the equation of state.

  5. The Operating Principle of a Fully Solid State Active Magnetic Regenerator

    SciTech Connect

    Abdelaziz, Omar

    2016-01-01

    As an alternative refrigeration technology, magnetocaloric refrigeration has the potential to be safer, quieter, more efficient, and more environmentally friendly than the conventional vapor compression refrigeration technology. Most of the reported active magnetic regenerator (AMR) systems that operate based on the magnetocaloric effect use heat transfer fluid to exchange heat, which results in complicated mechanical subsystems and components such as rotating valves and hydraulic pumps. This paper presents an operating principle of a fully solid state AMR, in which an alternative mechanism for heat transfer between the AMR and the heat source/sink is proposed. The operating principle of the fully solid state AMR is based on moving rods/sheets (e.g. copper, brass, iron or aluminum), which are employed to replace the heat transfer fluid. Such fully solid state AMR would provide a significantly higher heat transfer rate than a conventional AMR because the conductivity of moving solid rods/plates is high and it enables the increase in the machine operating frequency hence the cooling capacity. The details of operating principle are presented and discussed here. One of the key enabling features for this technology is the contact between the moving rods/sheets and magnetocaloric material, and heat exchange mechanism at the heat source/sink. This paper provides an overview of the design for a fully solid state magnetocaloric refrigeration system along with guidelines for their optimal design.

  6. Introduction to Cardiovascular Magnetic Resonance: Technical Principles and Clinical Applications

    PubMed Central

    Tseng, Wen-Yih Isaac; Su, Mao-Yuan Marine; Tseng, Yao-Hui Elton

    2016-01-01

    Cardiovascular magnetic resonance (CMR) is a set of magnetic resonance imaging (MRI) techniques designed to assess cardiovascular morphology, ventricular function, myocardial perfusion, tissue characterization, flow quantification and coronary artery disease. Since MRI is a non-invasive tool and free of radiation, it is suitable for longitudinal monitoring of treatment effect and follow-up of disease progress. Compared to MRI of other body parts, CMR faces specific challenges from cardiac and respiratory motion. Therefore, CMR requires synchronous cardiac and respiratory gating or breath-holding techniques to overcome motion artifacts. This article will review the basic principles of MRI and introduce the CMR techniques that can be optimized for enhanced clinical assessment. PMID:27122944

  7. Principles of ballistics applicable to the treatment of gunshot wounds.

    PubMed

    Swan, K G; Swan, R C

    1991-04-01

    Ballistics is the science of the motion of a projectile through the barrel of a firearm (internal ballistics), during its subsequent flight (external ballistics), and during its final complicated motion after it strikes a target (terminal ballistics). Wound ballistics is a special case of terminal ballistics. Although wound ballistics is at best sets of approximations, its principles enter usefully into an evaluation of a gunshot wound and its treatment. A special consideration in these cases is their medicolegal aspects. At a minimum, the medical team receiving the patient should exert care not to destroy the clothing and in particular to cut around and not through bullet holes, to turn over to law enforcement officials any metallic foreign body recovered from the patient, and to describe precisely, or even to photograph, any entrance or exit wounds.

  8. Application of ALARA principles to shipment of spent nuclear fuel

    SciTech Connect

    Greenborg, J.; Brackenbush, L.W.; Murphy, D.W. Burnett, R.A.; Lewis, J.R.

    1980-05-01

    The public exposure from spent fuel shipment is very low. In view of this low exposure and the perfect safety record for spent fuel shipment, existing systems can be considered satisfactory. On the other hand, occupational exposure reduction merits consideration and technology improvement to decrease dose should concentrate on this exposure. Practices that affect the age of spent fuel in shipment and the number of times the fuel must be shipped prior to disposal have the largest impact. A policy to encourage a 5-year spent fuel cooling period prior to shipment coupled with appropriate cask redesign to accommodate larger loads would be consistent with ALARA and economic principles. And finally, bypassing high population density areas will not in general reduce shipment dose.

  9. MR enterography in children: Principles, technique, and clinical applications.

    PubMed

    Chavhan, Govind B; Babyn, Paul S; Walters, Thomas

    2013-04-01

    MR enterography is a constantly advancing technique for assessment of bowel with newer technology and sequences. It is being increasingly used for the assessment of inflammatory bowel disease and has almost replaced barium follow through examinations in many institutions. Its lack of radiation makes it an attractive alternative for bowel evaluation in children. It has been proved to be highly sensitive in the detection of Crohn disease in adults and children. It is also superior to barium studies in showing extra-enteric findings and detecting complications such as fistulas and abscesses. Even though at present it is almost exclusively used for the evaluation of inflammatory bowel disease, it has the potential to be used in other conditions affecting the bowel. The principles, MR enterography technique pertinent to children, and its utility in the assessment of Crohn disease in children are discussed in this review.

  10. First-principles equation of state and electronic properties of warm dense oxygen

    SciTech Connect

    Driver, K. P. Soubiran, F.; Zhang, Shuai; Militzer, B.

    2015-10-28

    We perform all-electron path integral Monte Carlo (PIMC) and density functional theory molecular dynamics (DFT-MD) calculations to explore warm dense matter states of oxygen. Our simulations cover a wide density-temperature range of 1–100 g cm{sup −3} and 10{sup 4}–10{sup 9} K. By combining results from PIMC and DFT-MD, we are able to compute pressures and internal energies from first-principles at all temperatures and provide a coherent equation of state. We compare our first-principles calculations with analytic equations of state, which tend to agree for temperatures above 8 × 10{sup 6} K. Pair-correlation functions and the electronic density of states reveal an evolving plasma structure and ionization process that is driven by temperature and density. As we increase the density at constant temperature, we find that the ionization fraction of the 1s state decreases while the other electronic states move towards the continuum. Finally, the computed shock Hugoniot curves show an increase in compression as the first and second shells are ionized.

  11. First-principles equation of state and electronic properties of warm dense oxygen.

    PubMed

    Driver, K P; Soubiran, F; Zhang, Shuai; Militzer, B

    2015-10-28

    We perform all-electron path integral Monte Carlo (PIMC) and density functional theory molecular dynamics (DFT-MD) calculations to explore warm dense matter states of oxygen. Our simulations cover a wide density-temperature range of 1-100 g cm(-3) and 10(4)-10(9) K. By combining results from PIMC and DFT-MD, we are able to compute pressures and internal energies from first-principles at all temperatures and provide a coherent equation of state. We compare our first-principles calculations with analytic equations of state, which tend to agree for temperatures above 8 × 10(6) K. Pair-correlation functions and the electronic density of states reveal an evolving plasma structure and ionization process that is driven by temperature and density. As we increase the density at constant temperature, we find that the ionization fraction of the 1s state decreases while the other electronic states move towards the continuum. Finally, the computed shock Hugoniot curves show an increase in compression as the first and second shells are ionized.

  12. Electroporation-based technologies for medicine: principles, applications, and challenges.

    PubMed

    Yarmush, Martin L; Golberg, Alexander; Serša, Gregor; Kotnik, Tadej; Miklavčič, Damijan

    2014-07-11

    When high-amplitude, short-duration pulsed electric fields are applied to cells and tissues, the permeability of the cell membranes and tissue is increased. This increase in permeability is currently explained by the temporary appearance of aqueous pores within the cell membrane, a phenomenon termed electroporation. During the past four decades, advances in fundamental and experimental electroporation research have allowed for the translation of electroporation-based technologies to the clinic. In this review, we describe the theory and current applications of electroporation in medicine and then discuss current challenges in electroporation research and barriers to a more extensive spread of these clinical applications.

  13. Design principles for Fresnel lenses in telecentric applications

    NASA Astrophysics Data System (ADS)

    McCall, Brian; Claytor, Nelson

    2016-09-01

    Fresnel lenses have been found by some optical systems designers to be useful in combination with a main lens to provide quality telecentric images. Aspheric Fresnel lenses are an ideal choice for this application because they achieve a high degree of telecentricity across the entire field of view and introduce very little distortion. In a telecentric system consisting of an aspheric Fresnel lens and an off the shelf non-telecentric main lens, the design parameters are few. Aberration theory, constraints on the visibility of the grooves, and physical constraints can effectively be used to quickly determine if a solution exists for a given application and identify the solution space if it does.

  14. 10 CFR 440.12 - State application.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false State application. 440.12 Section 440.12 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION WEATHERIZATION ASSISTANCE FOR LOW-INCOME PERSONS § 440.12 State application. (a) To be eligible for financial assistance under this part, a State shall submit an...

  15. Integrative Nursing: Application of Principles Across Clinical Settings

    PubMed Central

    Kreitzer, Mary Jo

    2015-01-01

    While the essence of nursing has long been whole person (body, mind, and spirit) and whole system-focused, in reality the contemporary practice of nursing in many settings around the globe has become increasingly fragmented and de-stabilized. Nursing shortages in many parts of the world are significant, and hierarchies and bureaucracies often remove nurses from the point of care, be that the bedside, home, or clinic, replacing them with less skilled workers and filling their time with documentation and other administrative tasks. Integrative nursing is a framework for providing whole person/whole system care that is relationship-based and person-centered and focuses on improving the health and wellbeing of caregivers as well as those they serve. It is aligned with what is being called the “triple aim” in the United States—an effort focused on improving the patient experience (quality and satisfaction), improving the health of populations, and reducing the cost of care. The principles of integrative nursing offer clear and specific guidance that can shape and impact patient care in all clinical settings. PMID:25973268

  16. Lithium Batteries: A Practical Application of Chemical Principles

    NASA Astrophysics Data System (ADS)

    Treptow, Richard S.

    2003-09-01

    In recent years batteries have emerged in the marketplace that take advantage of the unique properties of lithium. Lithium metal is an attractive choice to serve as a battery anode because it is easily oxidized and it produces an exceptionally high amount of electrical charge per unit-weight. The electrolytes used in lithium batteries contain lithium salts dissolved in polar organic solvents. A variety of substances can serve as the battery cathode. They include inorganic solids, liquids, and dissolved gas. The cell potentials of lithium-metal batteries can be calculated from thermodynamic principles. These open-circuit voltages can be compared to the operating voltages of batteries delivering a current. Some lithium batteries employ intercalation compounds as their cathodes. These solids have layered or tunneled crystal structures into which lithium ions insert during the reduction process. When an intercalation cathode is paired with a lithiated-graphite anode, the resulting battery has the advantage of being rechargeable. It is known as a lithium-ion battery because no lithium metal is present.

  17. 29 CFR 780.138 - Application of the general principles.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... General Scope of Agriculture âsuch Farming Operationâ-of the Farmer § 780.138 Application of the general... incident to or in conjunction with his farming operations. Such arrangements are distinguished from those... incorporated association of farmers that does not itself engage in farming operations is not engaged...

  18. 29 CFR 780.138 - Application of the general principles.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... General Scope of Agriculture âsuch Farming Operationâ-of the Farmer § 780.138 Application of the general... incident to or in conjunction with his farming operations. Such arrangements are distinguished from those... incorporated association of farmers that does not itself engage in farming operations is not engaged...

  19. 29 CFR 780.138 - Application of the general principles.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... General Scope of Agriculture âsuch Farming Operationâ-of the Farmer § 780.138 Application of the general... incident to or in conjunction with his farming operations. Such arrangements are distinguished from those... incorporated association of farmers that does not itself engage in farming operations is not engaged...

  20. 29 CFR 780.138 - Application of the general principles.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... General Scope of Agriculture âsuch Farming Operationâ-of the Farmer § 780.138 Application of the general... incident to or in conjunction with his farming operations. Such arrangements are distinguished from those... incorporated association of farmers that does not itself engage in farming operations is not engaged...

  1. 29 CFR 780.138 - Application of the general principles.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... General Scope of Agriculture âsuch Farming Operationâ-of the Farmer § 780.138 Application of the general... incident to or in conjunction with his farming operations. Such arrangements are distinguished from those... incorporated association of farmers that does not itself engage in farming operations is not engaged...

  2. 17 CFR Appendix A to Part 39 - Application Guidance and Compliance With Core Principles

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Compliance With Core Principles A Appendix A to Part 39 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION DERIVATIVES CLEARING ORGANIZATIONS Pt. 39, App. A Appendix A to Part 39—Application... with which applicants must demonstrate the ability to comply and with which registered...

  3. Principles of Pesticide Use, Handling, and Application: Instructional Modules for Vocational Agriculture Education. Student Manual.

    ERIC Educational Resources Information Center

    Ellis Associates, Inc., College Park, MD.

    This training package is designed to present the basic principles of pesticide use, handling, and application. Included in this package is information on federal laws and regulations, personal safety, environmental implications, storage and disposal considerations, proper application procedures, and fundamentals of pest management. Successful…

  4. Principles of Pesticide Use, Handling, and Application: Instructional Modules for Vocational Agriculture Education. Teacher Manual.

    ERIC Educational Resources Information Center

    Ellis Associates, Inc., College Park, MD.

    The training package is designed to present the basic principles of pesticide use, handling, and application. Included in this package is information on Federal laws and regulations, personal safety, environmental implications, storage and disposal considerations, proper application procedures, and fundamentals of pest management. Successful…

  5. Applicability of the independence principle to subsonic turbulent flow over a swept rearward-facing step

    NASA Technical Reports Server (NTRS)

    Selby, G. V.

    1983-01-01

    Prandtl (1946) has concluded that for yawed laminar incompressible flows the streamwise flow is independent of the spanwise flow. However, Ashkenas and Riddell (1955) have reported that for turbulent flow the 'independence principle' does not apply to yawed flat plates. On the other hand, it was also found that this principle may be applicable to many turbulent flows. As the sweep angle is increased, a sweep angle is reached which defines the interval over which the 'independence principle' is valid. The results obtained in the present investigation indicate the magnitude of the critical angle for subsonic turbulent flow over a swept rearward-facing step.

  6. Principles and biotechnological applications of bacterial ice nucleation.

    PubMed

    Margaritis, A; Bassi, A S

    1991-01-01

    Certain aerobic, Gram-negative bacteria, including the epiphytic plant pathogen, Pseudomonas syringae, possess a membrane protein that enables them to nucleate crystallization in supercooled water. Currently, these ice-nucleating (IN) bacteria are being used in snow making and have potential applications in the production and texturing of frozen foods, and as a replacement of silver iodide in cloud seeding. A negative aspect of these IN bacteria is frost damage to plant surfaces. Thus, of the various types of biological ice nucleators, bacteria have been the subject of most research and also appear relevant to the anticipated practical uses. The intent of this review is to explain the identification and ecology of the ice-nucleating bacteria, as well as to discuss aspects of molecular biology related to ice nucleation and consider existing and potential applications of this unique phenomenon.

  7. Proteomic approaches in biological and medical sciences: principles and applications.

    PubMed

    Conrotto, P; Souchelnytskyi, S

    2008-09-01

    After the first introduction of the concept of "proteome" more than 10 years ago, large-scale studies of protein expression, localization, activities and interactions have gained an exponential increase of interest, leading to extensive research and technology development. Proteomics is expansively applied in many areas, ranging from basic research, various disease and malignant tumors diagnostic and biomarker discovery to therapeutic applications. Several proteomics approaches have been developed for protein separation and identification, and for the characterization of protein function and structure. Two-dimensional gel electrophoresis, chromatography, capillary electrophoresis and mass spectrometry have become the most used proteomics methods. These techniques are also under constant development. This review provides an overview of the main techniques and their combinations, used in proteomics. The emphasis is made on description of advantages and disadvantages of each technique, to navigate in selection of the best application for solving a specific problem.

  8. Digital micromirror devices: principles and applications in imaging.

    PubMed

    Bansal, Vivek; Saggau, Peter

    2013-05-01

    A digital micromirror device (DMD) is an array of individually switchable mirrors that can be used in many advanced optical systems as a rapid spatial light modulator. With a DMD, several implementations of confocal microscopy, hyperspectral imaging, and fluorescence lifetime imaging can be realized. The DMD can also be used as a real-time optical processor for applications such as the programmable array microscope and compressive sensing. Advantages and disadvantages of the DMD for these applications as well as methods to overcome some of the limitations will be discussed in this article. Practical considerations when designing with the DMD and sample optical layouts of a completely DMD-based imaging system and one in which acousto-optic deflectors (AODs) are used in the illumination pathway are also provided.

  9. Ultrafast transient absorption spectroscopy: principles and application to photosynthetic systems.

    PubMed

    Berera, Rudi; van Grondelle, Rienk; Kennis, John T M

    2009-01-01

    The photophysical and photochemical reactions, after light absorption by a photosynthetic pigment-protein complex, are among the fastest events in biology, taking place on timescales ranging from tens of femtoseconds to a few nanoseconds. The advent of ultrafast laser systems that produce pulses with femtosecond duration opened up a new area of research and enabled investigation of these photophysical and photochemical reactions in real time. Here, we provide a basic description of the ultrafast transient absorption technique, the laser and wavelength-conversion equipment, the transient absorption setup, and the collection of transient absorption data. Recent applications of ultrafast transient absorption spectroscopy on systems with increasing degree of complexity, from biomimetic light-harvesting systems to natural light-harvesting antennas, are presented. In particular, we will discuss, in this educational review, how a molecular understanding of the light-harvesting and photoprotective functions of carotenoids in photosynthesis is accomplished through the application of ultrafast transient absorption spectroscopy.

  10. Principles and application of antibody libraries for infectious diseases.

    PubMed

    Lim, Bee Nar; Tye, Gee Jun; Choong, Yee Siew; Ong, Eugene Boon Beng; Ismail, Asma; Lim, Theam Soon

    2014-12-01

    Antibodies have been used efficiently for the treatment and diagnosis of many diseases. Recombinant antibody technology allows the generation of fully human antibodies. Phage display is the gold standard for the production of human antibodies in vitro. To generate monoclonal antibodies by phage display, the generation of antibody libraries is crucial. Antibody libraries are classified according to the source where the antibody gene sequences were obtained. The most useful library for infectious diseases is the immunized library. Immunized libraries would allow better and selective enrichment of antibodies against disease antigens. The antibodies generated from these libraries can be translated for both diagnostic and therapeutic applications. This review focuses on the generation of immunized antibody libraries and the potential applications of the antibodies derived from these libraries.

  11. [Responsibility: Towards a fifth principle in blood transfusion's ethics. Applicability and limits of Hans Jonas's responsibility principle].

    PubMed

    Nélaton, C

    2016-09-01

    Nowadays, in France, anonymity, gratuity, volunteering, non-profit are recognized as ethical principles in blood transfusion. Can we add responsibility to this list? Can a logo named "Responsiblood" efficiently encourage blood donation? This article explores Hans Jonas's reform of the responsibility concept in order to measure its applicabilities and limits in the field of blood transfusion. Indeed, this concept - rethought by Jonas - seems to be a good encouragement which avoids the pitfalls of the concept of duty and of the idea of payment for blood donation. But can't we also see in this reform a threat to blood transfusion because of technophobia and the heuristics of fear that it involves?

  12. Design Principles for Covalent Organic Frameworks in Energy Storage Applications.

    PubMed

    Alahakoon, Sampath B; Thompson, Christina M; Occhialini, Gino; Smaldone, Ronald Alexander

    2017-03-16

    Covalent organic frameworks (COFs) are an exciting class of microporous materials that have been explored as energy storage materials for more than a decade. This review will discusses the efforts to develop these materials for applications in gas and electrical power storage. This review will also discuss some of the design strategies for developing the gas sorption properties of COFs and mechanistic studies on their formation.

  13. Application of First Principles Ni-Cd and Ni-H2 Battery Models to Spacecraft Operations

    NASA Technical Reports Server (NTRS)

    Timmerman, Paul; Bugga, Ratnakumar; DiStefano, Salvador

    1997-01-01

    The conclusions of the application of first principles model to spacecraft operations are: the first principles of Bi-phasic electrode presented model provides an explanation for many behaviors on voltage fading on LEO cycling.

  14. Flat-panel volume CT: fundamental principles, technology, and applications.

    PubMed

    Gupta, Rajiv; Cheung, Arnold C; Bartling, Soenke H; Lisauskas, Jennifer; Grasruck, Michael; Leidecker, Christianne; Schmidt, Bernhard; Flohr, Thomas; Brady, Thomas J

    2008-01-01

    Flat-panel volume computed tomography (CT) systems have an innovative design that allows coverage of a large volume per rotation, fluoroscopic and dynamic imaging, and high spatial resolution that permits visualization of complex human anatomy such as fine temporal bone structures and trabecular bone architecture. In simple terms, flat-panel volume CT scanners can be thought of as conventional multidetector CT scanners in which the detector rows have been replaced by an area detector. The flat-panel detector has wide z-axis coverage that enables imaging of entire organs in one axial acquisition. Its fluoroscopic and angiographic capabilities are useful for intraoperative and vascular applications. Furthermore, the high-volume coverage and continuous rotation of the detector may enable depiction of dynamic processes such as coronary blood flow and whole-brain perfusion. Other applications in which flat-panel volume CT may play a role include small-animal imaging, nondestructive testing in animal survival surgeries, and tissue-engineering experiments. Such versatility has led some to predict that flat-panel volume CT will gain importance in interventional and intraoperative applications, especially in specialties such as cardiac imaging, interventional neuroradiology, orthopedics, and otolaryngology. However, the contrast resolution of flat-panel volume CT is slightly inferior to that of multidetector CT, a higher radiation dose is needed to achieve a comparable signal-to-noise ratio, and a slower scintillator results in a longer scanning time.

  15. Principles and clinical applications of positron emission tomography.

    PubMed

    Gardner, S F; Green, J A; Bednarczyk, E M; Farnett, L; Miraldi, F

    1992-06-01

    The basics of positron emission tomography (PET) are presented, including the physics, instrumentation, and radiopharmaceuticals involved; the clinical and research applications; and the cost. In PET, organic molecules labeled with positron-emitting radionuclides are injected or inhaled, and the high-energy photons produced by annihilation events are detected by paired, integrated crystal detectors. A computer uses the lines of origin of these photons to reconstruct a three-dimensional map of a functioning organ system. The positron-emitting radionuclides most often used are carbon 11, oxygen 15, nitrogen 13, fluorine 18, and rubidium 82. PET imaging centers usually consist of a cyclotron facility, a radiochemistry facility, a PET scanner, and computers for image reconstruction. Radiopharmaceuticals used in PET may be divided into blood flow-imaging agents, metabolic imaging agents, and drug receptor-imaging agents. Although PET is still primarily a research tool, it has shown diagnostic potential in neurology, cardiology, and oncology. It has also shown promise as a tool for pharmacologic assessment, as in studies of the effects of the fluorinated quinolones on cerebral blood flow and glucose metabolism. PET may become important in drug development because it yields specific information relatively noninvasively. A single study carries an average break-even price tag of $1500-$2000; rigorous cost-benefit analyses should be conducted before society is asked to subsidize such costs. Positron emission tomography is a frontier technology for which valuable clinical applications are being discovered. Pharmacists can contribute enormously to PET applications and at the same time establish a unique subspecialty for the profession.

  16. Bibliographic study of georadar principles, applications, advantages, and inconvenience

    NASA Astrophysics Data System (ADS)

    Declerck, Paul

    Electromagnetic soil surveying has been studied for more than 20 years. The abundant number of references on the subject testifies to the many attempts that have been made to sound the subsurface soil by means of electromagnetic waves. This method has also been used to investigate structures such as tunnel walls and airfield pavements. Electromagnetic waves can be used to examine both soils and structures (bridge decks, tunnel walls, etc.). The possibilities offered by the technique are constantly increased by new developments in electronics and computer science. As a result, large quantities of measuring data and extensive signals processing (including Fourier analysis) are no longer an obstacle to the frequent use of soil-penetrating radar. The road industry too is very interested, with a view to applications such as investigating sites for new road construction, surveying existing road structures or probing for buried conduits or remnants of foundations, which may cause a lot of problems or entail substantial costs when carrying out road works. The literature survey reviews some 25 years of reporting on attempts to use electromagnetic pulses for nondestructive material testing. The applications of the technique were originally of a military nature, but now range from geology, archaeology, environmental management and mining to the investigation of structures, buildings, bridges and roads. The higher the frequency, the higher the resolution and the smaller the depth of penetration. Special antennas are required for specific applications such as the detection of linear structures (pipes, cables) or the investigation of walls and bridge decks. Radar is a fast, high-yield and continuous method of surveying and the waves are not stopped by voids or cracks, unlike acoustic waves or seismic vibrations. Radar operates well in poorly conducting materials and less well in wet or clayey soils. It is a very promising technique besides resistivity, infrared thermography and

  17. Cell cycle analysis by flow cytometry: principles and applications.

    PubMed

    Jayat, C; Ratinaud, M H

    1993-01-01

    Numerous flow cytometric analyses are based on DNA content studies. We have considered firstly monoparametric cell cycle analyses, which only take DNA content into account, but are sometimes of limited interest. Then, we have presented multiparametric analyses, which can be used to improve cycle phase identification by taking simultaneously into account DNA and other cellular components, or by considering some events occurring during cell cycle. Finally, we have discussed monoparametric and multiparametric cell cycle analysis interest in various application fields, particularly in pharmacology, toxicology, tumoral pathology and higher plant system studies.

  18. Solar cells: Operating principles, technology, and system applications

    NASA Astrophysics Data System (ADS)

    Green, M. A.

    Solar cell theory, materials, fabrication, design, modules, and systems are discussed. The solar source of light energy is described and quantified, along with a review of semiconductor properties and the generation, recombination, and the basic equations of photovoltaic device physics. Particular attention is given to p-n junction diodes, including efficiency limits, losses, and measurements. Si solar cell technology is described for the production of solar-quality crystals and wafers, and design, improvements, and device structures are examined. Consideration is given to alternate semiconductor materials and applications in concentrating systems, storage, and the design and construction of stand-alone systems and systems for residential and centralized power generation.

  19. High applicability of two-dimensional phosphorous in Kagome lattice predicted from first-principles calculations.

    PubMed

    Chen, Peng-Jen; Jeng, Horng-Tay

    2016-03-16

    A new semiconducting phase of two-dimensional phosphorous in the Kagome lattice is proposed from first-principles calculations. The band gaps of the monolayer (ML) and bulk Kagome phosphorous (Kagome-P) are 2.00 and 1.11 eV, respectively. The magnitude of the band gap is tunable by applying the in-plane strain and/or changing the number of stacking layers. High optical absorption coefficients at the visible light region are predicted for multilayer Kagome-P, indicating potential applications for solar cell devices. The nearly dispersionless top valence band of the ML Kagome-P with high density of states at the Fermi level leads to superconductivity with Tc of ~9 K under the optimal hole doping concentration. We also propose that the Kagome-P can be fabricated through the manipulation of the substrate-induced strain during the process of the sample growth. Our work demonstrates the high applicability of the Kagome-P in the fields of electronics, photovoltaics, and superconductivity.

  20. High applicability of two-dimensional phosphorous in Kagome lattice predicted from first-principles calculations

    PubMed Central

    Chen, Peng-Jen; Jeng, Horng-Tay

    2016-01-01

    A new semiconducting phase of two-dimensional phosphorous in the Kagome lattice is proposed from first-principles calculations. The band gaps of the monolayer (ML) and bulk Kagome phosphorous (Kagome-P) are 2.00 and 1.11 eV, respectively. The magnitude of the band gap is tunable by applying the in-plane strain and/or changing the number of stacking layers. High optical absorption coefficients at the visible light region are predicted for multilayer Kagome-P, indicating potential applications for solar cell devices. The nearly dispersionless top valence band of the ML Kagome-P with high density of states at the Fermi level leads to superconductivity with Tc of ~9 K under the optimal hole doping concentration. We also propose that the Kagome-P can be fabricated through the manipulation of the substrate-induced strain during the process of the sample growth. Our work demonstrates the high applicability of the Kagome-P in the fields of electronics, photovoltaics, and superconductivity. PMID:26980060

  1. Guided Bone Regeneration: biological principle and therapeutic applications.

    PubMed

    Retzepi, Maria; Donos, N

    2010-06-01

    The Guided Bone Regeneration (GBR) treatment concept advocates that regeneration of osseous defects is predictably attainable via the application of occlusive membranes, which mechanically exclude non-osteogenic cell populations from the surrounding soft tissues, thereby allowing osteogenic cell populations originating from the parent bone to inhabit the osseous wound. The present review discusses the evolution of the GBR biological rationale and therapeutic concept over the last two decades. Further, an overview of the GBR research history is provided with specific focus on the evidence available on its effectiveness and predictability in promoting the regeneration of critical size cranio-maxillo-facial defects, the neo-osteogenesis potential and the reconstruction of atrophic alveolar ridges before, or in conjunction with, the placement of dental implants. The authors conclude that future research should focus on (a) the investigation of the molecular mechanisms underlying the wound healing process following GBR application; (b) the identification of site and patient related factors which impact on the effectiveness and predictability of GBR therapy and (c) the evaluation of the pathophysiology of the GBR healing process in the presence of systemic conditions potentially affecting the skeletal system.

  2. Initial system-bath state via the maximum-entropy principle

    NASA Astrophysics Data System (ADS)

    Dai, Jibo; Len, Yink Loong; Ng, Hui Khoon

    2016-11-01

    The initial state of a system-bath composite is needed as the input for prediction from any quantum evolution equation to describe subsequent system-only reduced dynamics or the noise on the system from joint evolution of the system and the bath. The conventional wisdom is to write down an uncorrelated state as if the system and the bath were prepared in the absence of each other; yet, such a factorized state cannot be the exact description in the presence of system-bath interactions. Here, we show how to go beyond the simplistic factorized-state prescription using ideas from quantum tomography: We employ the maximum-entropy principle to deduce an initial system-bath state consistent with the available information. For the generic case of weak interactions, we obtain an explicit formula for the correction to the factorized state. Such a state turns out to have little correlation between the system and the bath, which we can quantify using our formula. This has implications, in particular, on the subject of subsequent non-completely positive dynamics of the system. Deviation from predictions based on such an almost uncorrelated state is indicative of accidental control of hidden degrees of freedom in the bath.

  3. Operating principles of an electrothermal vibrometer for optical switching applications

    NASA Astrophysics Data System (ADS)

    Pai, Min-fan; Tien, Norman C.

    1999-09-01

    A compact polysilicon surface-micromachined microactuator designed for optical switching applications is described. This actuator is fabricated using the foundry MUMPs process provided by Cronos Integrated Microsystems Inc. Actuated electrothermally, the microactuator allows fast switching speeds and can be operated with a low voltage square-wave signal. The design, operation mechanisms for this long-range and high frequency thermal actuation are described. A vertical micromirror integrated with this actuator can be operated with a 10.5 V, 20 kHz 15% duty-cycle pulse signal, achieving a lateral moving speed higher than 15.6 mm/sec. The optical switch has been operated to frequencies as high as 30 kHz.

  4. S-layer fusion proteins--construction principles and applications.

    PubMed

    Ilk, Nicola; Egelseer, Eva M; Sleytr, Uwe B

    2011-12-01

    Crystalline bacterial cell surface layers (S-layers) are the outermost cell envelope component of many bacteria and archaea. S-layers are monomolecular arrays composed of a single protein or glycoprotein species and represent the simplest biological membrane developed during evolution. The wealth of information available on the structure, chemistry, genetics and assembly of S-layers revealed a broad spectrum of applications in nanobiotechnology and biomimetics. By genetic engineering techniques, specific functional domains can be incorporated in S-layer proteins while maintaining the self-assembly capability. These techniques have led to new types of affinity structures, microcarriers, enzyme membranes, diagnostic devices, biosensors, vaccines, as well as targeting, delivery and encapsulation systems.

  5. Application of INCSEA principles to the Taiwan Strait.

    SciTech Connect

    Wen-Chung, Chai

    2003-06-01

    The waters surrounding Taiwan are important international waterways. In addition to merchant ships of every nation, the warships of the United States, Japan, Russia, and China may appear in these waters. No hostility is expected between Taiwan and the United States, Japan, or Russia; however, Taiwan and China have a tense relationship, and both sides face a potential for naval incidents. As Taiwan and China expand their naval capability, the International Maritime Organization Convention for the lnternational Regulations for Preventing Collisions at Sea may not be sufficient to prevent naval incidents, any of which might develop into conflict or war. Therefore, China and Taiwan need to develop maritime confidence building measures (CBMs) that could reduce the chance of naval incidents and strengthen mutual trust and confidence. Among the variety of maritime CBM concepts for military purposes, the most successful and effective measure has been the 1972 U.S.-Soviet Union Agreement on the Prevention of Incidents On and Over the High Seas (INCSEA). The success of the agreement demonstrates that CBMs represent a workable alternative to traditional arms controls. The purpose of this paper is to suggest a concrete approach to the constraint of naval activities between China and Taiwan to reduce accidents and misunderstandings. This paper outlines the categories and characteristics of incidents at sea. Next, the author identifies the successful factors of the U.S.-Soviet INCSEA and applies the INCSEA concept to the Taiwan Strait. Finally, the author develops a framework of options and a step-by-step approach for establishing an INCSEA between Taiwan and China.

  6. Thermophysical property data - Who needs them. [similarity principle applications in fluid mechanics and heat transfer

    NASA Technical Reports Server (NTRS)

    Hendricks, R. C.

    1979-01-01

    Specific examples are cited herein to illustrate the universal needs and demands for thermophysical property data. Applications of the principle of similarity in fluid mechanics and heat transfer and extensions of the principle to fluid mixtures are discussed. It becomes quite clear that no matter how eloquent theories or experiments in fluid mechanics or heat transfer are, the results of their application can be no more accurate than the thermophysical properties required to transform these theories into practice, or in the case of an experiment, to reduce the data. Present-day projects take place on such a scale that the need for international standards and mutual cooperation is evident.

  7. First-Principles Correlated Approach to the Normal State of Strontium Ruthenate

    NASA Astrophysics Data System (ADS)

    Acharya, S.; Laad, M. S.; Dey, Dibyendu; Maitra, T.; Taraphder, A.

    2017-02-01

    The interplay between multiple bands, sizable multi-band electronic correlations and strong spin-orbit coupling may conspire in selecting a rather unusual unconventional pairing symmetry in layered Sr2RuO4. This mandates a detailed revisit of the normal state and, in particular, the T-dependent incoherence-coherence crossover. Using a modern first-principles correlated view, we study this issue in the actual structure of Sr2RuO4 and present a unified and quantitative description of a range of unusual physical responses in the normal state. Armed with these, we propose that a new and important element, that of dominant multi-orbital charge fluctuations in a Hund’s metal, may be a primary pair glue for unconventional superconductivity. Thereby we establish a connection between the normal state responses and superconductivity in this system.

  8. First-Principles Correlated Approach to the Normal State of Strontium Ruthenate

    PubMed Central

    Acharya, S.; Laad, M. S.; Dey, Dibyendu; Maitra, T.; Taraphder, A.

    2017-01-01

    The interplay between multiple bands, sizable multi-band electronic correlations and strong spin-orbit coupling may conspire in selecting a rather unusual unconventional pairing symmetry in layered Sr2RuO4. This mandates a detailed revisit of the normal state and, in particular, the T-dependent incoherence-coherence crossover. Using a modern first-principles correlated view, we study this issue in the actual structure of Sr2RuO4 and present a unified and quantitative description of a range of unusual physical responses in the normal state. Armed with these, we propose that a new and important element, that of dominant multi-orbital charge fluctuations in a Hund’s metal, may be a primary pair glue for unconventional superconductivity. Thereby we establish a connection between the normal state responses and superconductivity in this system. PMID:28220879

  9. Hospital management principles applicable to the veterinary teaching hospital.

    PubMed

    Harris, Donna L; Lloyd, James W; Marrinan, Mike

    2004-01-01

    The Skills, Knowledge, Aptitude, and Attitude (SKA) Subcommittee of the National Commission on Veterinary Economic Issues (NCVEI) has identified the need for veterinary teaching hospitals (VTH) to be at the forefront of progressive business management to serve as a model for both students and practitioners to emulate. To provide a foundation for developing a model, this study reviewed pertinent literature applicable to the management of a VTH. Much of the literature relevant to VTH management relates to work completed for the human side of medicine (academic health centers, or AHCs) or to the private sector. This review explores management practices in strategic planning, financial management, human resource management, marketing, pricing, operations, and legal issues. It is concluded that strategic management is important to provide the foundation for success in the VTH. In addition, periodic financial reports are recommended, as are the development and use of benchmarks for financial management. Establishing positive, motivating human resource practices is also suggested, along with development of a marketing plan based on a clear understanding of VTH core competencies and the market's specific needs.

  10. Deuterium REDOR: Principles and Applications for Distance Measurements

    NASA Astrophysics Data System (ADS)

    Sack, I.; Goldbourt, A.; Vega, S.; Buntkowsky, G.

    1999-05-01

    The application of short composite pulse schemes ([figure] and [figure]) to the rotational echo double-resonance (REDOR) spectroscopy ofX-2H (X: spin{1}/{2}, observed) systems with large deuterium quadrupolar interactions has been studied experimentally and theoretically and compared with simple 180° pulse schemes. The basic properties of the composite pulses on the deuterium nuclei have been elucidated, using average Hamiltonian theory, and exact simulations of the experiments have been achieved by stepwise integration of the equation of motion of the density matrix. REDOR experiments were performed on15N-2H in doubly labeled acetanilide and on13C-2H in singly2H-labeled acetanilide. The most efficient REDOR dephasing was observed when [figure] composite pulses were used. It is found that the dephasing due to simple 180° deuterium pulses is about a factor of 2 less efficient than the dephasing due to the composite pulse sequences and thus the range of couplings observable byX-2H REDOR is enlarged toward weaker couplings, i.e., larger distances. From these experiments the2H-15N dipolar coupling between the amino deuteron and the amino nitrogen and the2H-13C dipolar couplings between the amino deuteron and the α and β carbons have been elucidated and the corresponding distances have been determined. The distance data from REDOR are in good agreement with data from X-ray and neutron diffraction, showing the power of the method.

  11. Adaptive laboratory evolution – principles and applications for biotechnology

    PubMed Central

    2013-01-01

    Adaptive laboratory evolution is a frequent method in biological studies to gain insights into the basic mechanisms of molecular evolution and adaptive changes that accumulate in microbial populations during long term selection under specified growth conditions. Although regularly performed for more than 25 years, the advent of transcript and cheap next-generation sequencing technologies has resulted in many recent studies, which successfully applied this technique in order to engineer microbial cells for biotechnological applications. Adaptive laboratory evolution has some major benefits as compared with classical genetic engineering but also some inherent limitations. However, recent studies show how some of the limitations may be overcome in order to successfully incorporate adaptive laboratory evolution in microbial cell factory design. Over the last two decades important insights into nutrient and stress metabolism of relevant model species were acquired, whereas some other aspects such as niche-specific differences of non-conventional cell factories are not completely understood. Altogether the current status and its future perspectives highlight the importance and potential of adaptive laboratory evolution as approach in biotechnological engineering. PMID:23815749

  12. Improved techniques for outgoing wave variational principle calculations of converged state-to-state transition probabilities for chemical reactions

    NASA Technical Reports Server (NTRS)

    Mielke, Steven L.; Truhlar, Donald G.; Schwenke, David W.

    1991-01-01

    Improved techniques and well-optimized basis sets are presented for application of the outgoing wave variational principle to calculate converged quantum mechanical reaction probabilities. They are illustrated with calculations for the reactions D + H2 yields HD + H with total angular momentum J = 3 and F + H2 yields HF + H with J = 0 and 3. The optimization involves the choice of distortion potential, the grid for calculating half-integrated Green's functions, the placement, width, and number of primitive distributed Gaussians, and the computationally most efficient partition between dynamically adapted and primitive basis functions. Benchmark calculations with 224-1064 channels are presented.

  13. Principles of TRIP Steel Optimization for Passive Damping Applications

    NASA Astrophysics Data System (ADS)

    Fraley, George Jay

    Globally many historic structures of cultural significance which do not have systems to mitigate seismic damage are located in areas with heavy seismic activity. Efforts have been undertaken to develop strategies to retrofit such structures, however any intervention must be limited in size for aesthetic reasons. To contribute to this effort, ArcelorMittal aims to create steel-based solutions for passive energy dissipation through plastic deformation during cyclic loading. High-strength TRansformation-Induced Plasticity (TRIP) steels are proposed as an excellent candidate material for this application, due to the extreme combination of high strength and large ductility they are well-known to exhibit. To evaluate high-strength TRIP steels for passive damping applications, isothermal, fully-reversed, displacement-controlled Ultra-Low Cycle Fatigue (ULCF) experiments (Nf < 100) were conducted on two tempering conditions of austenitic BlastAlloy (BA) TRIP 180. One tempering condition resulted in a Mssigma temperature of 27 °C and stress-assisted martensitic nucleation, and the other a Mssigma temperature of -8 °C and strain-induced martensitic nucleation at room temperature. The higher austenite stability condition (Ms sigma = -8 °C) was found to have approximately twice the fatigue life and a lower rate of cyclic hardening at fixed displacement amplitudes for low to intermediate levels of plastic strain range (2-10%) compared to the lower stability austenite condition (Mssigma = 27 °C). However, at higher levels of plastic straining (10-16% strain range) the fatigue lives and strain hardening behavior converged for the two stabilities, indicating a likely exhaustion of transformation during the first few cycles. ULCF life behavior for the high-stability austenite condition compared favorably with literature values for structural stainless steel 316, despite having a yield strength approximately four times larger. For a similar number of cycles to failure the high

  14. Using Uncertainty Principle to Find the Ground-State Energy of the Helium and a Helium-like Hookean Atom

    ERIC Educational Resources Information Center

    Harbola, Varun

    2011-01-01

    In this paper, we accurately estimate the ground-state energy and the atomic radius of the helium atom and a helium-like Hookean atom by employing the uncertainty principle in conjunction with the variational approach. We show that with the use of the uncertainty principle, electrons are found to be spread over a radial region, giving an electron…

  15. Principles of computer processing of Landsat data for geologic applications

    USGS Publications Warehouse

    Taranik, James V.

    1978-01-01

    The main objectives of computer processing of Landsat data for geologic applications are to improve display of image data to the analyst or to facilitate evaluation of the multispectral characteristics of the data. Interpretations of the data are made from enhanced and classified data by an analyst trained in geology. Image enhancements involve adjustments of brightness values for individual picture elements. Image classification involves determination of the brightness values of picture elements for a particular cover type. Histograms are used to display the range and frequency of occurrence of brightness values. Landsat-1 and -2 data are preprocessed at Goddard Space Flight Center (GSFC) to adjust for the detector response of the multispectral scanner (MSS). Adjustments are applied to minimize the effects of striping, adjust for bad-data lines and line segments and lost individual pixel data. Because illumination conditions and landscape characteristics vary considerably and detector response changes with time, the radiometric adjustments applied at GSFC are seldom perfect and some detector striping remain in Landsat data. Rotation of the Earth under the satellite and movements of the satellite platform introduce geometric distortions in the data that must also be compensated for if image data are to be correctly displayed to the data analyst. Adjustments to Landsat data are made to compensate for variable solar illumination and for atmospheric effects. GeoMetric registration of Landsat data involves determination of the spatial location of a pixel in. the output image and the determination of a new value for the pixel. The general objective of image enhancement is to optimize display of the data to the analyst. Contrast enhancements are employed to expand the range of brightness values in Landsat data so that the data can be efficiently recorded in a manner desired by the analyst. Spatial frequency enhancements are designed to enhance boundaries between features

  16. Principles and applications of measurement and uncertainty analysis in research and calibration

    SciTech Connect

    Wells, C.V.

    1992-11-01

    Interest in Measurement Uncertainty Analysis has grown in the past several years as it has spread to new fields of application, and research and development of uncertainty methodologies have continued. This paper discusses the subject from the perspectives of both research and calibration environments. It presents a history of the development and an overview of the principles of uncertainty analysis embodied in the United States National Standard, ANSI/ASME PTC 19.1-1985, Measurement Uncertainty. Examples are presented in which uncertainty analysis was utilized or is needed to gain further knowledge of a particular measurement process and to characterize final results. Measurement uncertainty analysis provides a quantitative estimate of the interval about a measured value or an experiment result within which the true value of that quantity is expected to lie. Years ago, Harry Ku of the United States National Bureau of Standards stated that The informational content of the statement of uncertainty determines, to a large extent, the worth of the calibrated value.'' Today, that statement is just as true about calibration or research results as it was in 1968. Why is that true What kind of information should we include in a statement of uncertainty accompanying a calibrated value How and where do we get the information to include in an uncertainty statement How should we interpret and use measurement uncertainty information This discussion will provide answers to these and other questions about uncertainty in research and in calibration. The methodology to be described has been developed by national and international groups over the past nearly thirty years, and individuals were publishing information even earlier. Yet the work is largely unknown in many science and engineering arenas. I will illustrate various aspects of uncertainty analysis with some examples drawn from the radiometry measurement and calibration discipline from research activities.

  17. Principles and applications of measurement and uncertainty analysis in research and calibration

    SciTech Connect

    Wells, C.V.

    1992-11-01

    Interest in Measurement Uncertainty Analysis has grown in the past several years as it has spread to new fields of application, and research and development of uncertainty methodologies have continued. This paper discusses the subject from the perspectives of both research and calibration environments. It presents a history of the development and an overview of the principles of uncertainty analysis embodied in the United States National Standard, ANSI/ASME PTC 19.1-1985, Measurement Uncertainty. Examples are presented in which uncertainty analysis was utilized or is needed to gain further knowledge of a particular measurement process and to characterize final results. Measurement uncertainty analysis provides a quantitative estimate of the interval about a measured value or an experiment result within which the true value of that quantity is expected to lie. Years ago, Harry Ku of the United States National Bureau of Standards stated that ``The informational content of the statement of uncertainty determines, to a large extent, the worth of the calibrated value.`` Today, that statement is just as true about calibration or research results as it was in 1968. Why is that true? What kind of information should we include in a statement of uncertainty accompanying a calibrated value? How and where do we get the information to include in an uncertainty statement? How should we interpret and use measurement uncertainty information? This discussion will provide answers to these and other questions about uncertainty in research and in calibration. The methodology to be described has been developed by national and international groups over the past nearly thirty years, and individuals were publishing information even earlier. Yet the work is largely unknown in many science and engineering arenas. I will illustrate various aspects of uncertainty analysis with some examples drawn from the radiometry measurement and calibration discipline from research activities.

  18. Application of cognitive engineering principles to the redesign of a dichotomous identification key for parasitology.

    PubMed

    Smith-Akin, Kimberly A; McLane, Sharon; Craig, Thomas M; Johnson, Todd R

    2006-01-01

    Dichotomous identification keys are used throughout biology for identification of plants, insects, and parasites. However, correct use of identification keys can be difficult as they are not usually intended for novice users who may not be familiar with the terminology used or with the morphology of the organism being identified. Therefore, we applied cognitive engineering principles to redesign a parasitology identification key for the Internet. We addressed issues of visual clutter and spatial distance by displaying a single question couplet at a time and by switching to the appropriate next couplet after the user made a choice. Our analysis of the original paper-based key versus the Web-based approach found that of 26 applicable cognitive engineering principles, the paper key did not meet 4 (15%) and partially met 11 (42%). In contrast, the redesigned key met 100% of 32 applicable cognitive engineering principles.

  19. Lean Principles and Defense Information Technology Acquisition: An Investigation of the Determinants of Successful Application

    ERIC Educational Resources Information Center

    Haley, M.

    2013-01-01

    The purpose of this study was to investigate whether or not there have been successful applications of lean manufacturing principles in highly variable defense IT environments. Specifically, the study assessed if implementation of the lean philosophies by a defense organization yielded repeatable, predictable results in software release schedules…

  20. Uniqueness of Zinc as a Bioelement: Principles and Applications in Bioinorganic Chemistry--III.

    ERIC Educational Resources Information Center

    Ochiai, Ei-Ichiro

    1988-01-01

    Attempts to delineate certain basic principles and applications of bioinorganic chemistry to oxidation-reduction reactions. Examines why zinc(II) is so uniquely suited to enzymated reactions of the acid-base type. Suggests the answer may be in the natural abundance and the basic physicochemical properties of zinc(II). (MVL)

  1. Modification of Taba's Application of Principles and Social Studies Inference Tests. A Progress Report.

    ERIC Educational Resources Information Center

    Wulff, Kenneth R.

    An updated version of Taba's 1966 "Social Studies Inference Test" and "Application of Principles Test" for elementary students is studied. The original tests measured students' abilities to generalize and draw inferences from short paragraphs containing data relevant to social studies. The "Social Studies Inference…

  2. The Application of Service-Learning Principles to Support Our National Parks

    ERIC Educational Resources Information Center

    Coates, Tom

    2005-01-01

    Camping and working and learning in national parks may sound like a great way to spend the summer, but for participants enrolled in Rocky Mountain Experience, it is much more. Rocky Mountain Experience is a unique university course that focuses on application of service-learning principles as students travel to, camp in, and complete service…

  3. Application of the Total Quality Management Approach Principles and the ISO 9000 Standards in Engineering Education.

    ERIC Educational Resources Information Center

    Waks, Shlomo; Frank, Moti

    1999-01-01

    Discusses the applicability of the definition, principles, and underlying strategies of total quality management (TQM) for engineering education. Describes several tools and methods for the implementation of TQM and its suitability for a variety of school activities. Presents a TQM course outline combining lectures, discussions, suggested…

  4. Application of the comparison principle to analysis of nonlinear systems. [using Lipschitz condition and differential equations

    NASA Technical Reports Server (NTRS)

    Gunderson, R. W.

    1975-01-01

    A comparison principle based on a Kamke theorem and Lipschitz conditions is presented along with its possible applications and modifications. It is shown that the comparison lemma can be used in the study of such areas as classical stability theory, higher order trajectory derivatives, Liapunov functions, boundary value problems, approximate dynamic systems, linear and nonlinear systems, and bifurcation analysis.

  5. Equation of state for technetium from X-ray diffraction and first-principle calculations

    SciTech Connect

    Mast, Daniel S.; Kim, Eunja; Siska, Emily M.; Poineau, Frederic; Czerwinski, Kenneth R.; Lavina, Barbara; Forster, Paul M.

    2016-03-20

    Here, the ambient temperature equation of state (EoS) of technetium metal has been measured by X-ray diffraction. The metal was compressed using a diamond anvil cell and using a 4:1 methanol-ethanol pressure transmitting medium. The maximum pressure achieved, as determined from the gold pressure scale, was 67 GPa. The compression data shows that the HCP phase of technetium is stable up to 67 GPa. The compression curve of technetium was also calculated using first-principles total-energy calculations. Utilizing a number of fitting strategies to compare the experimental and theoretical data it is determined that the Vinet equation of state with an ambient isothermal bulk modulus of B0T = 288 GPa and a first pressure derivative of B' = 5.9(2) best represent the compression behavior of technetium metal.

  6. Equation of state for technetium from X-ray diffraction and first-principle calculations

    DOE PAGES

    Mast, Daniel S.; Kim, Eunja; Siska, Emily M.; ...

    2016-03-20

    Here, the ambient temperature equation of state (EoS) of technetium metal has been measured by X-ray diffraction. The metal was compressed using a diamond anvil cell and using a 4:1 methanol-ethanol pressure transmitting medium. The maximum pressure achieved, as determined from the gold pressure scale, was 67 GPa. The compression data shows that the HCP phase of technetium is stable up to 67 GPa. The compression curve of technetium was also calculated using first-principles total-energy calculations. Utilizing a number of fitting strategies to compare the experimental and theoretical data it is determined that the Vinet equation of state with anmore » ambient isothermal bulk modulus of B0T = 288 GPa and a first pressure derivative of B' = 5.9(2) best represent the compression behavior of technetium metal.« less

  7. First-principles equation of state of polystyrene and its effect on inertial confinement fusion implosions

    DOE PAGES

    Hu, S. X.; Collins, L. A.; Goncharov, V. N.; ...

    2015-10-14

    Obtaining an accurate equation of state (EOS) of polystyrene (CH) is crucial to reliably design inertial confinement fusion (ICF) capsules using CH/CH-based ablators. Thus, with first-principles calculations, we have investigated the extended EOS of CH over a wide range of plasma conditions (ρ = 0.1 to 100 g/cm3 and T = 1,000 to 4,000,000 K). When compared with the widely used SESAME-EOS table, the first-principles equation of state (FPEOS) of CH has shown significant differences in the low-temperature regime, in which strong coupling and electron degeneracy play an essential role in determining plasma properties. Hydrodynamic simulations of cryogenic target implosionsmore » on OMEGA using the FPEOS table of CH have predicted ~5% reduction in implosion velocity and ~30% decrease in neutron yield in comparison with the usual SESAME simulations. This is attributed to the ~10% lower mass ablation rate of CH predicted by FPEOS. Simulations using CH-FPEOS show better agreement with measurements of Hugoniot temperature and scattered lights from ICF implosions.« less

  8. Towards a new welfare state: the social sustainability principle and health care strategies.

    PubMed

    Garcés, Jorge; Ródenas, Francisco; Sanjosé, Vicente

    2003-09-01

    In this paper we propose a social and health care model that offers alternatives to three problems arising in converging European welfare states, particularly in the southern nations: the rise in demand for services and features linked to the ageing process, the increase in dependency and the crisis of informal support. Development of the principles of social sustainability implies re-formulation of the regulatory, care, economic, administrative, cultural, and axiological framework enabling a response to the needs of long term care without compromising the welfare of future generations. Together with this principle, quality of life elevated to a subjective right directs attention towards the sphere closest to citizens, eliminating all barriers, which hamper exercise of this right. All of the above produces economic and social costs which must be accepted from a viewpoint of social co-responsibility, which brings with it the supply of welfare individually, without detriment to the exercise of state responsibility in guaranteeing a social protection system of a universal nature.

  9. First principles calculations of solid-state thermionic transport in layered van der Waals heterostructures.

    PubMed

    Wang, Xiaoming; Zebarjadi, Mona; Esfarjani, Keivan

    2016-08-21

    This work aims at understanding solid-state energy conversion and transport in layered (van der Waals) heterostructures in contact with metallic electrodes via a first-principles approach. As an illustration, a graphene/phosphorene/graphene heterostructure in contact with gold electrodes is studied by using density functional theory (DFT)-based first principles calculations combined with real space Green's function (GF) formalism. We show that for a monolayer phosphorene, quantum tunneling dominates the transport. By adding more phosphorene layers, one can switch from tunneling-dominated transport to thermionic-dominated transport, resulting in transporting more heat per charge carrier, thus, enhancing the cooling coefficient of performance. The use of layered van der Waals heterostructures has two advantages: (a) thermionic transport barriers can be tuned by changing the number of layers, and (b) thermal conductance across these non-covalent structures is very weak. The phonon thermal conductance of the present van der Waals heterostructure is found to be 4.1 MW m(-2) K(-1) which is one order of magnitude lower than the lowest value for that of covalently-bonded interfaces. The thermionic coefficient of performance for the proposed device is 18.5 at 600 K corresponding to an equivalent ZT of 0.13, which is significant for nanoscale devices. This study shows that layered van der Waals structures have great potential to be used as solid-state energy-conversion devices.

  10. First-principles equation of state of polystyrene and its effect on inertial confinement fusion implosions

    SciTech Connect

    Hu, S. X.; Collins, L. A.; Goncharov, V. N.; Kress, J. D.; McCrory, R. L.; Skupsky, S.

    2015-10-14

    Obtaining an accurate equation of state (EOS) of polystyrene (CH) is crucial to reliably design inertial confinement fusion (ICF) capsules using CH/CH-based ablators. Thus, with first-principles calculations, we have investigated the extended EOS of CH over a wide range of plasma conditions (ρ = 0.1 to 100 g/cm3 and T = 1,000 to 4,000,000 K). When compared with the widely used SESAME-EOS table, the first-principles equation of state (FPEOS) of CH has shown significant differences in the low-temperature regime, in which strong coupling and electron degeneracy play an essential role in determining plasma properties. Hydrodynamic simulations of cryogenic target implosions on OMEGA using the FPEOS table of CH have predicted ~5% reduction in implosion velocity and ~30% decrease in neutron yield in comparison with the usual SESAME simulations. This is attributed to the ~10% lower mass ablation rate of CH predicted by FPEOS. Simulations using CH-FPEOS show better agreement with measurements of Hugoniot temperature and scattered lights from ICF implosions.

  11. First-principles equation of state of polystyrene and its effect on inertial confinement fusion implosions.

    PubMed

    Hu, S X; Collins, L A; Goncharov, V N; Kress, J D; McCrory, R L; Skupsky, S

    2015-10-01

    Obtaining an accurate equation of state (EOS) of polystyrene (CH) is crucial to reliably design inertial confinement fusion (ICF) capsules using CH/CH-based ablators. With first-principles calculations, we have investigated the extended EOS of CH over a wide range of plasma conditions (ρ=0.1to100g/cm(3) and T=1000 to 4,000,000 K). When compared with the widely used SESAME-EOS table, the first-principles equation of state (FPEOS) of CH has shown significant differences in the low-temperature regime, in which strong coupling and electron degeneracy play an essential role in determining plasma properties. Hydrodynamic simulations of cryogenic target implosions on OMEGA using the FPEOS table of CH have predicted ∼30% decrease in neutron yield in comparison with the usual SESAME simulations. This is attributed to the ∼5% reduction in implosion velocity that is caused by the ∼10% lower mass ablation rate of CH predicted by FPEOS. Simulations using CH-FPEOS show better agreement with measurements of Hugoniot temperature and scattered light from ICF implosions.

  12. First-principles equation of state of polystyrene and its effect on inertial confinement fusion implosions

    NASA Astrophysics Data System (ADS)

    Hu, S. X.; Collins, L. A.; Goncharov, V. N.; Kress, J. D.; McCrory, R. L.; Skupsky, S.

    2015-10-01

    Obtaining an accurate equation of state (EOS) of polystyrene (CH) is crucial to reliably design inertial confinement fusion (ICF) capsules using CH/CH-based ablators. With first-principles calculations, we have investigated the extended EOS of CH over a wide range of plasma conditions (ρ =0.1 to 100 g /cm3 and T =1000 to 4 000 000 K ). When compared with the widely used SESAME-EOS table, the first-principles equation of state (FPEOS) of CH has shown significant differences in the low-temperature regime, in which strong coupling and electron degeneracy play an essential role in determining plasma properties. Hydrodynamic simulations of cryogenic target implosions on OMEGA using the FPEOS table of CH have predicted ˜30% decrease in neutron yield in comparison with the usual SESAME simulations. This is attributed to the ˜5% reduction in implosion velocity that is caused by the ˜10% lower mass ablation rate of CH predicted by FPEOS. Simulations using CH-FPEOS show better agreement with measurements of Hugoniot temperature and scattered light from ICF implosions.

  13. The child's right to an open future: is the principle applicable to non-therapeutic circumcision?

    PubMed

    Darby, Robert J L

    2013-07-01

    The principle of the child's right to an open future was first proposed by the legal philosopher Joel Feinberg and developed further by bioethicist Dena Davis. The principle holds that children possess a unique class of rights called rights in trust-rights that they cannot yet exercise, but which they will be able to exercise when they reach maturity. Parents should not, therefore, take actions that permanently foreclose on or pre-empt the future options of their children, but leave them the greatest possible scope for exercising personal life choices in adulthood. Davis particularly applies the principle to genetic counselling, arguing that parents should not take deliberate steps to create physically abnormal children, and to religion, arguing that while parents are entitled to bring their children up in accordance with their own values, they are not entitled to inflict physical or mental harm, neither by omission nor commission. In this paper, I aim to elucidate the open future principle, and consider whether it is applicable to non-therapeutic circumcision of boys, whether performed for cultural/religious or for prophylactic/health reasons. I argue that the principle is highly applicable to non-therapeutic circumcision, and conclude that non-therapeutic circumcision would be a violation of the child's right to an open future, and thus objectionable from both an ethical and a human rights perspective.

  14. First-Principles Study of Muon Trapping in Singlet and Triplet States of Oxyhemoglobin

    NASA Astrophysics Data System (ADS)

    Pink, Roger; Badu, S. R.; Das, T. P.; Sahoo, N.; Chow, Lee; Scheicher, R. H.; Nagamine, K.

    2012-02-01

    There is great current interest in the possibility of magnetic character in oxyhemoglobin (OxyHb) due to the detection [1] of muon spin-lattice relaxation in OxyHb. First-Principles variational Hartree-Fock Many Body Perturbation Theory (VHFMBPT) technique investigations on the singlet and triplet states of pure OxyHb have shown^2 that the triplet state is considerably higher than the singlet state ruling out magnetic character. However the charge distribution obtained by the VHFMBPT procedure in both states show a number of sites that have negative charges where the trapping of muon is being investigated to examine if the energy gap in the ordering of singlet and triplet states can be reduced or reversed leading to magnetic effects. Other possible sources of magnetism in Oxyhemoglobin will also be discussed. 1. K. Nagamine et al. Proc. Japan. Acad. B-Physics 83, 120 (2007); 2. S.R. Badu et al. Reported at Third Joint HFI-NQI International Conference, CERN, Geneva, September 2010.

  15. The uncertainty principle and a semiclassical nonlinear differential equation formulation for bound states

    NASA Astrophysics Data System (ADS)

    Mukhopadhyay, S.; Bhattacharyya, K.

    2000-10-01

    The kinship of a simple variational scheme involving the uncertainty product with a prevalent semiclassical nonlinear differential equation approach for finding energies of stationary states is established. This leads to a transparent physical interpretation of the embedded parameters in the latter approach, providing additionally a lower bound to the integration constant. The domain of applicability of this strategy is also extended to encompass neighbouring states. Other advantages of the simpler alternative route are stressed. Pilot calculations demonstrate nicely the efficacy of the endeavour.

  16. Generalized coherent states and their applications

    NASA Astrophysics Data System (ADS)

    Perelomov, Askol'd. Mikhailovich

    The theory of generalized coherent states is presented in a systematic manner. In particular, attention is given to the conventional system of coherent states and its relation to the Heisenberg-Weyl group; coherent states for an arbitrary Lie group; coherent states for a group of three-dimensional space rotations; and coherent states for a boson system with a finite number of degrees of freedom. Physical applications of generalized coherent states are discussed with reference to the quantum oscillator, particles in an external magnetic field, Landau diamagnetism, and synchrotron radiation.

  17. THE ROLE OF METASTABLE STATES IN POLYMER PHASE TRANSITIONS: Concepts, Principles, and Experimental Observations

    NASA Astrophysics Data System (ADS)

    Cheng, Stephen Z. D.; Keller, Andrew

    1998-08-01

    Polymer phases can be described in the same way as phases in other condensed matter using a number density operator and its correlation functions. This description requires the understanding of symmetry operations and order at different atomic and molecular levels. Statistical mechanics provides a link between the microscopic description of the structure and motion and the macroscopic thermodynamic properties. Within the limits of the laws of thermodynamics, polymers exhibit a rich variety of phase transition behaviors. By definition, a first-order phase transition describes a transformation that involves a sudden change of thermodynamic properties at its transition temperature, whereas higher-order phase transitions are classified as critical phenomena. Of special interest is the role of metastability in phase and phase transition behaviors. Although a metastable state possesses a local free energy minimum, it is not at the global equilibrium. Furthermore, metastable states can also be associated with phase sizes. Metastable behavior is also observed in phase transformations that are impeded by kinetic limitations along the pathway to thermodynamic equilibrium. This is illustrated in structural and morphological investigations of crystallization and mesophase transitions, liquid-liquid phase separation, vitrification, and gel formation, as well as combinations of transformation processes. In these cases, the metastable state often becomes the dominant state for the entire system and is observed over a range of time and size scales. This review describes the general principles of metastability in polymer phases and phase transitions and provides illustrations from current experimental works in selected areas.

  18. Electric tuning of the surface and quantum well states in Bi2Se3 films: a first-principles study

    SciTech Connect

    Yang, Hong; Peng, Xiangyang; Liu, Wenliang; Wei, Xiaolin; Hao, Guolin; He, Chaoyu; Li, Jin; Stocks, George Malcolm; Zhong, Jianxin

    2014-01-01

    Based on first-principles calculations in the framework of van der Waals density functional theory, we find that giant, Rashba-like spin splittings can be induced in both the surface states and quantum well states of thin Bi2Se3 films by application of an external electric field. The charge is redistributed so that the Dirac cones of the upper and lower surfaces become nondegenerate and completely gapless. Interestingly, a momentum-dependent spin texture is developed on the two surfaces of the films. Some of the quantum well states, which reside in the middle of the Bi2Se3 film under zero field, are driven to the surface by the electric field. The Rashba splitting energy has a highly non-linear dependence on the momentum and the electric field due to the large contribution of the high-order Rashba terms, which suggests complex spin dynamics in the thin films of Bi2Se3 under an electric field.

  19. Electronic properties of corrugated graphene: the Heisenberg principle and wormhole geometry in the solid state.

    PubMed

    Atanasov, Victor; Saxena, Avadh

    2011-05-04

    Adopting a purely two-dimensional relativistic equation for graphene's carriers contradicts the Heisenberg uncertainty principle since it requires setting the off-the-surface coordinate of a three-dimensional wavefunction to zero. Here we present a theoretical framework for describing graphene's massless relativistic carriers in accordance with this most fundamental of all quantum principles. A gradual confining procedure is used to restrict the dynamics onto a surface and normal to the surface parts, and in the process the embedding of this surface into the three-dimensional world is accounted for. As a result an invariant geometric potential arises in the surface part which scales linearly with the mean curvature and shifts the Fermi energy of the material proportional to bending. Strain induced modification of the electronic properties or 'straintronics' is clearly an important field of study in graphene. This opens an avenue to producing electronic devices: micro- and nano-electromechanical systems (MEMS and NEMS), where the electronic properties are controlled by geometric means and no additional alteration of graphene is necessary. The appearance of this geometric potential also provides us with clues as to how quantum dynamics looks in the curved space-time of general relativity. In this context we explore a two-dimensional cross-section of the wormhole geometry, realized with graphene as a solid state thought experiment.

  20. 18 CFR 740.3 - State applications.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... water management planning program, or modifications thereto, as required by § 740.4(a); (3) A work plan of the major program activities of the State water management planning program which targets... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false State applications....

  1. 18 CFR 740.3 - State applications.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... water management planning program, or modifications thereto, as required by § 740.4(a); (3) A work plan of the major program activities of the State water management planning program which targets... 18 Conservation of Power and Water Resources 2 2013-04-01 2012-04-01 true State applications....

  2. 18 CFR 740.3 - State applications.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... water management planning program, or modifications thereto, as required by § 740.4(a); (3) A work plan of the major program activities of the State water management planning program which targets... 18 Conservation of Power and Water Resources 2 2014-04-01 2014-04-01 false State applications....

  3. 18 CFR 740.3 - State applications.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... water management planning program, or modifications thereto, as required by § 740.4(a); (3) A work plan of the major program activities of the State water management planning program which targets... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false State applications....

  4. 18 CFR 740.3 - State applications.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... water management planning program, or modifications thereto, as required by § 740.4(a); (3) A work plan of the major program activities of the State water management planning program which targets... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false State applications....

  5. First principles calculations of solid-state thermionic transport in layered van der Waals heterostructures

    NASA Astrophysics Data System (ADS)

    Wang, Xiaoming; Zebarjadi, Mona; Esfarjani, Keivan

    2016-08-01

    This work aims at understanding solid-state energy conversion and transport in layered (van der Waals) heterostructures in contact with metallic electrodes via a first-principles approach. As an illustration, a graphene/phosphorene/graphene heterostructure in contact with gold electrodes is studied by using density functional theory (DFT)-based first principles calculations combined with real space Green's function (GF) formalism. We show that for a monolayer phosphorene, quantum tunneling dominates the transport. By adding more phosphorene layers, one can switch from tunneling-dominated transport to thermionic-dominated transport, resulting in transporting more heat per charge carrier, thus, enhancing the cooling coefficient of performance. The use of layered van der Waals heterostructures has two advantages: (a) thermionic transport barriers can be tuned by changing the number of layers, and (b) thermal conductance across these non-covalent structures is very weak. The phonon thermal conductance of the present van der Waals heterostructure is found to be 4.1 MW m-2 K-1 which is one order of magnitude lower than the lowest value for that of covalently-bonded interfaces. The thermionic coefficient of performance for the proposed device is 18.5 at 600 K corresponding to an equivalent ZT of 0.13, which is significant for nanoscale devices. This study shows that layered van der Waals structures have great potential to be used as solid-state energy-conversion devices.This work aims at understanding solid-state energy conversion and transport in layered (van der Waals) heterostructures in contact with metallic electrodes via a first-principles approach. As an illustration, a graphene/phosphorene/graphene heterostructure in contact with gold electrodes is studied by using density functional theory (DFT)-based first principles calculations combined with real space Green's function (GF) formalism. We show that for a monolayer phosphorene, quantum tunneling dominates the

  6. Electronic Excited States in Amorphous MEH-PPV Polymers from Large-Scale First Principles Calculations.

    PubMed

    Ma, Haibo; Qin, Ting; Troisi, Alessandro

    2014-03-11

    The electronic excited states of amorphous polymeric semiconductor MEH-PPV are investigated by first principles quantum chemical calculations based on trajectories from classical molecular dynamics simulations. We inferred an average conjugation length of ∼5-7 monomers for lowest vertical excitations of amorphous MEH-PPV at room temperature and verified that the normal definition of a chromophore in a polymer based on purely geometric "conjugation breaks" is not always valid in amorphous polymers and a rigorous definition can be only on the basis of the evaluation of the polymer excited state wave function. The charge transfer character is observed to be nearly invariant for all excited states in low energy window while the exciton delocalization extent is found to increase with energy. The interchain excitonic couplings for amorphous MEH-PPV are shown to be usually smaller than 10 meV suggesting that the transport mechanism across chain can be described by incoherent hopping. All these observations about the energetic and spatial distribution of the excitons in polymer as well as their couplings provide important qualitative insights and useful quantitative information for constructing a realistic model for exciton migration dynamics in amorphous polymer materials.

  7. First-principles Equations of State and Shock Hugoniots of First- and Second-Row Plasmas

    NASA Astrophysics Data System (ADS)

    Driver, Kevin; Soubiran, Francois; Zhang, Shuai; Militzer, Burkhard

    A first-principles methodology for studying high energy density physics and warm dense matter is important for the stewardship of plasma science and guiding inertial confinement fusion experiments. In order to address this challenge, we have been developing the capability of path integral Monte Carlo (PIMC) for studying dense plasmas comprised of increasingly heavy elements, including nitrogen, oxygen, and neon. In recent work, we have extended PIMC methodology beyond the free-particle node approximation by implementing localized nodal surfaces capable of describing bound plasma states in second-row elements, such as silicon. We combine results from PIMC with results from density functional theory molecular dynamics (DFT-MD) calculations to produce a coherent equation of state that bridges the entire WDM regime. Analysis of pair-correlation functions and the electronic density of states reveals an evolving plasma structure and ionization process that is driven by temperature and pressure. We also compute shock Hugoniot curves for a wide range of initial densities, which generally reveal an increase in compression as the second and first shells are ionized. This work is funded by the NSF/DOE Partnership in Basic Plasma Science and Engineering (DE-SC0010517).

  8. Thermodynamic ground state of MgB{sub 6} predicted from first principles structure search methods

    SciTech Connect

    Wang, Hui; LeBlanc, K. A.; Gao, Bo; Yao, Yansun

    2014-01-28

    Crystalline structures of magnesium hexaboride, MgB{sub 6}, were investigated using unbiased structure searching methods combined with first principles density functional calculations. An orthorhombic Cmcm structure was predicted as the thermodynamic ground state of MgB{sub 6}. The energy of the Cmcm structure is significantly lower than the theoretical MgB{sub 6} models previously considered based on a primitive cubic arrangement of boron octahedra. The Cmcm structure is stable against the decomposition to elemental magnesium and boron solids at atmospheric pressure and high pressures up to 18.3 GPa. A unique feature of the predicted Cmcm structure is that the boron atoms are clustered into two forms: localized B{sub 6} octahedra and extended B{sub ∞} ribbons. Within the boron ribbons, the electrons are delocalized and this leads to a metallic ground state with vanished electric dipoles. The present prediction is in contrast to the previous proposal that the crystalline MgB{sub 6} maintains a semiconducting state with permanent dipole moments. MgB{sub 6} is estimated to have much weaker electron-phonon coupling compared with that of MgB{sub 2}, and therefore it is not expected to be able to sustain superconductivity at high temperatures.

  9. A survey of parametrized variational principles and applications to computational mechanics

    NASA Technical Reports Server (NTRS)

    Felippa, Carlos A.

    1993-01-01

    This survey paper describes recent developments in the area of parametrized variational principles (PVP's) and selected applications to finite-element computational mechanics. A PVP is a variational principle containing free parameters that have no effect on the Euler-Lagrange equations. The theory of single-field PVP's based on gauge functions (also known as null Lagrangians) is a subset of the inverse problem of variational calculus that has limited value. On the other hand, multifield PVP's are more interesting from theoretical and practical standpoints. Following a tutorial introduction, the paper describes the recent construction of multifield PVP's in several areas of elasticity and electromagnetics. It then discusses three applications to finite-element computational mechanics: the derivation of high-performance finite elements, the development of element-level error indicators, and the constructions of finite element templates. The paper concludes with an overview of open research areas.

  10. Quantitative Phase Imaging Techniques for the Study of Cell Pathophysiology: From Principles to Applications

    PubMed Central

    Lee, KyeoReh; Kim, Kyoohyun; Jung, Jaehwang; Heo, JiHan; Cho, Sangyeon; Lee, Sangyun; Chang, Gyuyoung; Jo, YoungJu; Park, Hyunjoo; Park, YongKeun

    2013-01-01

    A cellular-level study of the pathophysiology is crucial for understanding the mechanisms behind human diseases. Recent advances in quantitative phase imaging (QPI) techniques show promises for the cellular-level understanding of the pathophysiology of diseases. To provide important insight on how the QPI techniques potentially improve the study of cell pathophysiology, here we present the principles of QPI and highlight some of the recent applications of QPI ranging from cell homeostasis to infectious diseases and cancer. PMID:23539026

  11. Principles of ESCA and application to metal corrosion, coating and lubrication

    NASA Technical Reports Server (NTRS)

    Wheeler, D. R.

    1978-01-01

    The principles of ESCA (electron spectroscopy for chemical analysis) were described by comparison with other spectroscopic techniques. The advantages and disadvantages of ESCA as compared to other surface sensitive analytical techniques were evaluated. The use of ESCA was illustrated by actual applications to oxidation of steel and Rene 41, the chemistry of lubricant additives on steel, and the composition of sputter deposited hard coatings. A bibliography of material that was useful for further study of ESCA was presented and commented upon.

  12. 15 CFR Notes Applicable to State... - Notes applicable to State of Understanding related to Medical Equipment:

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... the practice of medicine (does not include medical research). (2) Commodities or software are... Understanding related to Medical Equipment: applicable Notes applicable to State of Understanding related to Medical Equipment: Commerce and Foreign Trade Regulations Relating to Commerce and Foreign...

  13. High-throughput spectrometer designs in a compact form-factor: principles and applications

    NASA Astrophysics Data System (ADS)

    Norton, S. M.

    2013-05-01

    Many compact, portable Raman spectrometers have entered the market in the past few years with applications in narcotics and hazardous material identification, as well as verification applications in pharmaceuticals and security screening. Often, the required compact form-factor has forced designers to sacrifice throughput and sensitivity for portability and low-cost. We will show that a volume phase holographic (VPH)-based spectrometer design can achieve superior throughput and thus sensitivity over conventional Czerny-Turner reflective designs. We will look in depth at the factors influencing throughput and sensitivity and illustrate specific VPH-based spectrometer examples that highlight these design principles.

  14. First-principles effective Hamiltonian simulation of ABO3-type perovskite ferroelectrics for energy storage application

    NASA Astrophysics Data System (ADS)

    Luo, Bingcheng; Wang, Xiaohui; Tian, Enke; Wu, Longwen; Li, Longtu

    2016-08-01

    Dielectric materials with high power density and energy density are eagerly desired for the potential application in advanced pulsed capacitors. Here, we present the first-principles effective Hamiltonian simulation of perovskite ferroelectrics BaTiO3, PbTiO3, and KNbO3 in order to better predict and design materials for energy storage application. The lattice constant, dielectric constant and ferroelectric hysteresis, and energy-storage density of BaTiO3, PbTiO3, and KNbO3 were calculated with the consideration of the effects of temperature and external electric field.

  15. State Water Resources Control Board, California Agreement in Principle 1995 summary report

    SciTech Connect

    Laudon, L.

    1996-03-01

    The Agreement in Principle (AIP) was established as part of the Secretary of Energy`s Ten-Point Initiative which was announced in 1989. One of the Secretary`s goals was to integrate the Department of Energy`s (DOE) national security mission with their environmental restoration and compliance responsibilities. In an effort to accomplish this goal, DOE increased the role of the states in the oversight of DOE`s monitoring programs through AIPs. The State of California and DOE negotiated the California AIP beginning in 1989 and signed the Agreement in September 1990. The AIP identified six DOE facilities to be evaluated under the program. The six facilities evaluated by the AIP program were: (1) Lawrence Livermore National Laboratory (LLNL) including LLNL`s Site 300; (2) Sandia National Laboratories, California (SNL/CA); (3) Lawrence Berkeley Laboratory (LBL); (4) Stanford Linear Accelerator Center (SLAC); (5) Energy Technology Engineering Center (ETEC); and (6) Laboratory for Energy-Related Health Research (LEHR).

  16. Temperature effects in first-principles solid state calculations of the chemical shielding tensor made simple

    SciTech Connect

    Monserrat, Bartomeu Needs, Richard J.; Pickard, Chris J.

    2014-10-07

    We study the effects of atomic vibrations on the solid-state chemical shielding tensor using first principles density functional theory calculations. At the harmonic level, we use a Monte Carlo method and a perturbative expansion. The Monte Carlo method is accurate but computationally expensive, while the perturbative method is computationally more efficient, but approximate. We find excellent agreement between the two methods for both the isotropic shift and the shielding anisotropy. The effects of zero-point quantum mechanical nuclear motion are important up to relatively high temperatures: at 500 K they still represent about half of the overall vibrational contribution. We also investigate the effects of anharmonic vibrations, finding that their contribution to the zero-point correction to the chemical shielding tensor is small. We exemplify these ideas using magnesium oxide and the molecular crystals L-alanine and β-aspartyl-L-alanine. We therefore propose as the method of choice to incorporate the effects of temperature in solid state chemical shielding tensor calculations using the perturbative expansion within the harmonic approximation. This approach is accurate and requires a computational effort that is about an order of magnitude smaller than that of dynamical or Monte Carlo approaches, so these effects might be routinely accounted for.

  17. Temperature effects in first-principles solid state calculations of the chemical shielding tensor made simple

    NASA Astrophysics Data System (ADS)

    Monserrat, Bartomeu; Needs, Richard J.; Pickard, Chris J.

    2014-10-01

    We study the effects of atomic vibrations on the solid-state chemical shielding tensor using first principles density functional theory calculations. At the harmonic level, we use a Monte Carlo method and a perturbative expansion. The Monte Carlo method is accurate but computationally expensive, while the perturbative method is computationally more efficient, but approximate. We find excellent agreement between the two methods for both the isotropic shift and the shielding anisotropy. The effects of zero-point quantum mechanical nuclear motion are important up to relatively high temperatures: at 500 K they still represent about half of the overall vibrational contribution. We also investigate the effects of anharmonic vibrations, finding that their contribution to the zero-point correction to the chemical shielding tensor is small. We exemplify these ideas using magnesium oxide and the molecular crystals L-alanine and β-aspartyl-L-alanine. We therefore propose as the method of choice to incorporate the effects of temperature in solid state chemical shielding tensor calculations using the perturbative expansion within the harmonic approximation. This approach is accurate and requires a computational effort that is about an order of magnitude smaller than that of dynamical or Monte Carlo approaches, so these effects might be routinely accounted for.

  18. Ab initio optimization principle for the ground states of translationally invariant strongly correlated quantum lattice models.

    PubMed

    Ran, Shi-Ju

    2016-05-01

    In this work, a simple and fundamental numeric scheme dubbed as ab initio optimization principle (AOP) is proposed for the ground states of translational invariant strongly correlated quantum lattice models. The idea is to transform a nondeterministic-polynomial-hard ground-state simulation with infinite degrees of freedom into a single optimization problem of a local function with finite number of physical and ancillary degrees of freedom. This work contributes mainly in the following aspects: (1) AOP provides a simple and efficient scheme to simulate the ground state by solving a local optimization problem. Its solution contains two kinds of boundary states, one of which play the role of the entanglement bath that mimics the interactions between a supercell and the infinite environment, and the other gives the ground state in a tensor network (TN) form. (2) In the sense of TN, a novel decomposition named as tensor ring decomposition (TRD) is proposed to implement AOP. Instead of following the contraction-truncation scheme used by many existing TN-based algorithms, TRD solves the contraction of a uniform TN in an opposite way by encoding the contraction in a set of self-consistent equations that automatically reconstruct the whole TN, making the simulation simple and unified; (3) AOP inherits and develops the ideas of different well-established methods, including the density matrix renormalization group (DMRG), infinite time-evolving block decimation (iTEBD), network contractor dynamics, density matrix embedding theory, etc., providing a unified perspective that is previously missing in this fields. (4) AOP as well as TRD give novel implications to existing TN-based algorithms: A modified iTEBD is suggested and the two-dimensional (2D) AOP is argued to be an intrinsic 2D extension of DMRG that is based on infinite projected entangled pair state. This paper is focused on one-dimensional quantum models to present AOP. The benchmark is given on a transverse Ising

  19. Ab initio optimization principle for the ground states of translationally invariant strongly correlated quantum lattice models

    NASA Astrophysics Data System (ADS)

    Ran, Shi-Ju

    2016-05-01

    In this work, a simple and fundamental numeric scheme dubbed as ab initio optimization principle (AOP) is proposed for the ground states of translational invariant strongly correlated quantum lattice models. The idea is to transform a nondeterministic-polynomial-hard ground-state simulation with infinite degrees of freedom into a single optimization problem of a local function with finite number of physical and ancillary degrees of freedom. This work contributes mainly in the following aspects: (1) AOP provides a simple and efficient scheme to simulate the ground state by solving a local optimization problem. Its solution contains two kinds of boundary states, one of which play the role of the entanglement bath that mimics the interactions between a supercell and the infinite environment, and the other gives the ground state in a tensor network (TN) form. (2) In the sense of TN, a novel decomposition named as tensor ring decomposition (TRD) is proposed to implement AOP. Instead of following the contraction-truncation scheme used by many existing TN-based algorithms, TRD solves the contraction of a uniform TN in an opposite way by encoding the contraction in a set of self-consistent equations that automatically reconstruct the whole TN, making the simulation simple and unified; (3) AOP inherits and develops the ideas of different well-established methods, including the density matrix renormalization group (DMRG), infinite time-evolving block decimation (iTEBD), network contractor dynamics, density matrix embedding theory, etc., providing a unified perspective that is previously missing in this fields. (4) AOP as well as TRD give novel implications to existing TN-based algorithms: A modified iTEBD is suggested and the two-dimensional (2D) AOP is argued to be an intrinsic 2D extension of DMRG that is based on infinite projected entangled pair state. This paper is focused on one-dimensional quantum models to present AOP. The benchmark is given on a transverse Ising

  20. 10 CFR 455.130 - State evaluation of grant applications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...(b), any additional requirements of the approved State Plan, State environmental laws, and other applicable laws and regulations, then such application will be eligible for financial assistance....

  1. 10 CFR 455.130 - State evaluation of grant applications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...(b), any additional requirements of the approved State Plan, State environmental laws, and other applicable laws and regulations, then such application will be eligible for financial assistance....

  2. 10 CFR 455.130 - State evaluation of grant applications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...(b), any additional requirements of the approved State Plan, State environmental laws, and other applicable laws and regulations, then such application will be eligible for financial assistance....

  3. 10 CFR 455.130 - State evaluation of grant applications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...(b), any additional requirements of the approved State Plan, State environmental laws, and other applicable laws and regulations, then such application will be eligible for financial assistance....

  4. The Principle of Energetic Consistency: Application to the Shallow-Water Equations

    NASA Technical Reports Server (NTRS)

    Cohn, Stephen E.

    2009-01-01

    If the complete state of the earth's atmosphere (e.g., pressure, temperature, winds and humidity, everywhere throughout the atmosphere) were known at any particular initial time, then solving the equations that govern the dynamical behavior of the atmosphere would give the complete state at all subsequent times. Part of the difficulty of weather prediction is that the governing equations can only be solved approximately, which is what weather prediction models do. But weather forecasts would still be far from perfect even if the equations could be solved exactly, because the atmospheric state is not and cannot be known completely at any initial forecast time. Rather, the initial state for a weather forecast can only be estimated from incomplete observations taken near the initial time, through a process known as data assimilation. Weather prediction models carry out their computations on a grid of points covering the earth's atmosphere. The formulation of these models is guided by a mathematical convergence theory which guarantees that, given the exact initial state, the model solution approaches the exact solution of the governing equations as the computational grid is made more fine. For the data assimilation process, however, there does not yet exist a convergence theory. This book chapter represents an effort to begin establishing a convergence theory for data assimilation methods. The main result, which is called the principle of energetic consistency, provides a necessary condition that a convergent method must satisfy. Current methods violate this principle, as shown in earlier work of the author, and therefore are not convergent. The principle is illustrated by showing how to apply it as a simple test of convergence for proposed methods.

  5. Equation of state and shock compression of warm dense sodium-A first-principles study.

    PubMed

    Zhang, Shuai; Driver, Kevin P; Soubiran, François; Militzer, Burkhard

    2017-02-21

    As one of the simple alkali metals, sodium has been of fundamental interest for shock physics experiments, but knowledge of its equation of state (EOS) in hot, dense regimes is not well known. By combining path integral Monte Carlo (PIMC) results for partially ionized states [B. Militzer and K. P. Driver, Phys. Rev. Lett. 115, 176403 (2015)] at high temperatures and density functional theory molecular dynamics (DFT-MD) results at lower temperatures, we have constructed a coherent equation of state for sodium over a wide density-temperature range of 1.93-11.60 g/cm(3) and 10(3)-1.29×10(8) K. We find that a localized, Hartree-Fock nodal structure in PIMC yields pressures and internal energies that are consistent with DFT-MD at intermediate temperatures of 2×10(6) K. Since PIMC and DFT-MD provide a first-principles treatment of electron shell and excitation effects, we are able to identify two compression maxima in the shock Hugoniot curve corresponding to K-shell and L-shell ionization. Our Hugoniot curves provide a benchmark for widely used EOS models: SESAME, LEOS, and Purgatorio. Due to the low ambient density, sodium has an unusually high first compression maximum along the shock Hugoniot curve. At beyond 10(7) K, we show that the radiation effect leads to very high compression along the Hugoniot curve, surpassing relativistic corrections, and observe an increasing deviation of the shock and particle velocities from a linear relation. We also compute the temperature-density dependence of thermal and pressure ionization processes.

  6. Equation of state and shock compression of warm dense sodium—A first-principles study

    NASA Astrophysics Data System (ADS)

    Zhang, Shuai; Driver, Kevin P.; Soubiran, François; Militzer, Burkhard

    2017-02-01

    As one of the simple alkali metals, sodium has been of fundamental interest for shock physics experiments, but knowledge of its equation of state (EOS) in hot, dense regimes is not well known. By combining path integral Monte Carlo (PIMC) results for partially ionized states [B. Militzer and K. P. Driver, Phys. Rev. Lett. 115, 176403 (2015)] at high temperatures and density functional theory molecular dynamics (DFT-MD) results at lower temperatures, we have constructed a coherent equation of state for sodium over a wide density-temperature range of 1.93-11.60 g/cm3 and 103-1.29 ×108 K. We find that a localized, Hartree-Fock nodal structure in PIMC yields pressures and internal energies that are consistent with DFT-MD at intermediate temperatures of 2 ×106 K. Since PIMC and DFT-MD provide a first-principles treatment of electron shell and excitation effects, we are able to identify two compression maxima in the shock Hugoniot curve corresponding to K-shell and L-shell ionization. Our Hugoniot curves provide a benchmark for widely used EOS models: SESAME, LEOS, and Purgatorio. Due to the low ambient density, sodium has an unusually high first compression maximum along the shock Hugoniot curve. At beyond 107 K, we show that the radiation effect leads to very high compression along the Hugoniot curve, surpassing relativistic corrections, and observe an increasing deviation of the shock and particle velocities from a linear relation. We also compute the temperature-density dependence of thermal and pressure ionization processes.

  7. Clinical applications of resting state functional connectivity.

    PubMed

    Fox, Michael D; Greicius, Michael

    2010-01-01

    During resting conditions the brain remains functionally and metabolically active. One manifestation of this activity that has become an important research tool is spontaneous fluctuations in the blood oxygen level-dependent (BOLD) signal of functional magnetic resonance imaging (fMRI). The identification of correlation patterns in these spontaneous fluctuations has been termed resting state functional connectivity (fcMRI) and has the potential to greatly increase the translation of fMRI into clinical care. In this article we review the advantages of the resting state signal for clinical applications including detailed discussion of signal to noise considerations. We include guidelines for performing resting state research on clinical populations, outline the different areas for clinical application, and identify important barriers to be addressed to facilitate the translation of resting state fcMRI into the clinical realm.

  8. Clinical Applications of Resting State Functional Connectivity

    PubMed Central

    Fox, Michael D.; Greicius, Michael

    2010-01-01

    During resting conditions the brain remains functionally and metabolically active. One manifestation of this activity that has become an important research tool is spontaneous fluctuations in the blood oxygen level-dependent (BOLD) signal of functional magnetic resonance imaging (fMRI). The identification of correlation patterns in these spontaneous fluctuations has been termed resting state functional connectivity (fcMRI) and has the potential to greatly increase the translation of fMRI into clinical care. In this article we review the advantages of the resting state signal for clinical applications including detailed discussion of signal to noise considerations. We include guidelines for performing resting state research on clinical populations, outline the different areas for clinical application, and identify important barriers to be addressed to facilitate the translation of resting state fcMRI into the clinical realm. PMID:20592951

  9. A game plan: Gamification design principles in mHealth applications for chronic disease management.

    PubMed

    Miller, Aaron S; Cafazzo, Joseph A; Seto, Emily

    2016-06-01

    Effective chronic disease management is essential to improve positive health outcomes, and incentive strategies are useful in promoting self-care with longevity. Gamification, applied with mHealth (mobile health) applications, has the potential to better facilitate patient self-management. This review article addresses a knowledge gap around the effective use of gamification design principles, or mechanics, in developing mHealth applications. Badges, leaderboards, points and levels, challenges and quests, social engagement loops, and onboarding are mechanics that comprise gamification. These mechanics are defined and explained from a design and development perspective. Health and fitness applications with gamification mechanics include: bant which uses points, levels, and social engagement, mySugr which uses challenges and quests, RunKeeper which uses leaderboards as well as social engagement loops and onboarding, Fitocracy which uses badges, and Mango Health, which uses points and levels. Specific design considerations are explored, an example of the efficacy of a gamified mHealth implementation in facilitating improved self-management is provided, limitations to this work are discussed, a link between the principles of gaming and gamification in health and wellness technologies is provided, and suggestions for future work are made. We conclude that gamification could be leveraged in developing applications with the potential to better facilitate self-management in persons with chronic conditions.

  10. Improving animal research facility operations through the application of lean principles.

    PubMed

    Khan, Nabeel; Umrysh, Brian M

    2008-06-01

    Animal research is a vital component of US research and well-functioning animal research facilities are critical both to the research itself and to the housing and feeding of the animals. The Office of Animal Care (OAC) at Seattle Children's Hospital Research Institute realized it had to improve the efficiency and safety of its animal research facility (ARF) to prepare for expansion and to advance the Institute's mission. The main areas for improvement concerned excessive turnaround time to process animal housing and feeding equipment; the movement and flow of equipment and inventory; and personnel safety. To address these problems, management held two process improvement workshops to educate employees about lean principles. In this article we discuss the application of these principles and corresponding methods to advance Children's Research Institute's mission of preventing, treating, and eliminating childhood diseases.

  11. Limitations and Extensions of the Lock-and-Key Principle: Differences between Gas State, Solution and Solid State Structures

    PubMed Central

    Schneider, Hans-Jörg

    2015-01-01

    The lock-and-key concept is discussed with respect to necessary extensions. Formation of supramolecular complexes depends not only, and often not even primarily on an optimal geometric fit between host and guest. Induced fit and allosteric interactions have long been known as important modifications. Different binding mechanisms, the medium used and pH effects can exert a major influence on the affinity. Stereoelectronic effects due to lone pair orientation can lead to variation of binding constants by orders of magnitude. Hydrophobic interactions due to high-energy water inside cavities modify the mechanical lock-and-key picture. That optimal affinities are observed if the cavity is only partially filled by the ligand can be in conflict with the lock-and-key principle. In crystals other forces than those between host and guest often dominate, leading to differences between solid state and solution structures. This is exemplified in particular with calixarene complexes, which by X-ray analysis more often than other hosts show guest molecules outside their cavity. In view of this the particular problems with the identification of weak interactions in crystals is discussed. PMID:25815592

  12. 2 CFR Appendix A to Part 220 - Principles for Determining Costs Applicable to Grants, Contracts, and Other Agreements With...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Principles for Determining Costs Applicable to Grants, Contracts, and Other Agreements With Educational Institutions A Appendix A to Part 220 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET CIRCULARS AND GUIDANCE Reserved COST PRINCIPLES FOR EDUCATIONAL INSTITUTIONS (OMB CIRCULAR...

  13. Surface states and positron annihilation spectroscopy: results and prospects from a first-principles approach

    NASA Astrophysics Data System (ADS)

    Callewaert, V.; Saniz, R.; Barbiellini, B.; Partoens, B.

    2017-01-01

    The trapping of positrons at the surface of a material can be exploited to study quite selectively the surface properties of the latter by means of positron annihilation spectroscopy techniques. To support these, it is desirable to be able to theoretically predict the existence of such positronic surface states and to describe their annihilation characteristics with core or valence surface electrons in a reliable way. Here, we build on the well-developed first-principles techniques for the study of positrons in bulk solids as well as on previous models for surfaces, and investigate two schemes that can improve the theoretical description of the interaction of positrons with surfaces. One is based on supplementing the local-density correlation potential with the corrugated image potential at the surface, and the other is based on the weighted-density approximation to correlation. We discuss our results for topological insulators, graphene layers, and quantum dots, with emphasis on the information that can be directly related to experiment. We also discuss some open theoretical problems that should be addressed by future research.

  14. Nanomechanical resonators and their applications in biological/chemical detection: Nanomechanics principles

    NASA Astrophysics Data System (ADS)

    Eom, Kilho; Park, Harold S.; Yoon, Dae Sung; Kwon, Taeyun

    2011-06-01

    Recent advances in nanotechnology have led to the development of nano-electro-mechanical systems (NEMS) such as nanomechanical resonators, which have recently received significant attention from the scientific community. This is not only due to their capability of label-free detection of bio/chemical molecules at single-molecule (or atomic) resolution for future applications such as the early diagnosis of diseases like cancer, but also due to their unprecedented ability to detect physical quantities such as molecular weight, elastic stiffness, surface stress, and surface elastic stiffness for adsorbed molecules on the surface. Most experimental works on resonator-based molecular detection have been based on the principle that molecular adsorption onto a resonator surface increases the effective mass, and consequently decreases the resonant frequencies of the nanomechanical resonator. However, this principle is insufficient to provide fundamental insights into resonator-based molecular detection at the nanoscale; this is due to recently proposed novel nanoscale detection principles including various effects such as surface effects, nonlinear oscillations, coupled resonance, and stiffness effects. Furthermore, these effects have only recently been incorporated into existing physical models for resonators, and therefore the universal physical principles governing nanoresonator-based detection have not been completely described. Therefore, our objective in this review is to overview the current attempts to understand the underlying mechanisms in nanoresonator-based detection using physical models coupled to computational simulations and/or experiments. Specifically, we will focus on issues of special relevance to the dynamic behavior of nanoresonators and their applications in biological/chemical detection: the resonance behavior of micro/nanoresonators; resonator-based chemical/biological detection; physical models of various nanoresonators such as nanowires, carbon

  15. Principles and applications of imaging radar. Manual of remote sensing: Third edition, Volume 2

    SciTech Connect

    Henderson, F.M.; Lewis, A.J.

    1998-12-31

    This second volume in the Third Edition of the Manual of Remote Sensing offers a current and comprehensive survey of the theory, methods, and applications of imaging radar for geoscientists, engineers and application scientists interested in the advantages of radar remote sensing. Produced under the auspices of the American Society for Photogrammetry and Remote Sensing, it brings together contributions from experts around the world to discuss the basic principles of imaging radars and trace the research activity--past, present, and future--across the many sciences where radar remote sensing may be applied. This book offers an invaluable snapshot of radar remote sensing technology, including radargrammetry, radar polarimetry and interferometry and its uses. It combines technical and procedural coverage of systems, data interpretation, and other fundamentals with generous coverage of practical applications in agriculture; forestry; soil moisture monitoring; geology; geomorphology and hydrology; oceanography; land use, land cover mapping and archeology.

  16. Fourier-bessel series modeling of dielectrophoretic bionanoparticle transport: principles and applications.

    PubMed

    Bakewell, David J; Chichenkov, Aleksandr

    2012-03-01

    Principles and applications are described for a Fourier-Bessel series model that predicts the transport of bionanoparticles driven by a dielectrophoretic (DEP) force and randomized by Brownian motion. The model is applicable for a dielectrophoretic force that spatially decays from the electrode array according to a reciprocal-law; that is, in the near field of a planar interdigitated array or in the far field where other long range forces assist DEP transport, e.g., ac electro-osmosis. Capabilities of the model are demonstrated for estimating and decomposing data typical of dielectrophoretic bionanoparticle collection experiments. An important approximation, for moderately strong DEP forces, is that a collection can largely be described by a single exponential profile with a square-law dependence on microdevice chamber height. Applications of the model demonstrate transformation and representation of time-dependent bionanoparticle transport in the frequency domain and prediction of a modulation bandwidth that concurs with experimental observations.

  17. Performance of First-Principles-Based Reaction Class Transition State Theory.

    PubMed

    Ratkiewicz, Artur; Huynh, Lam K; Truong, Thanh N

    2016-03-03

    Performance of the Reaction Class Transition State Theory (RC-TST) for prediction of rates constants of elementary reactions is examined using data from its previous applications to a number of different reaction classes. The RC-TST theory is taking advantage of the common structure denominator of all reactions in a given family combined with structure activity relationships to provide a rigorous theoretical framework to obtain rate expression of any reaction within a reaction class in a simple and cost-effective manner. This opens the possibility for integrating this methodology with an automated mechanism generator for "on-the-fly" generation of accurate kinetic models of complex reacting systems.

  18. Proof-of-principle test of coherent-state continuous variable quantum key distribution through turbulent atmosphere (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Derkach, Ivan D.; Peuntinger, Christian; Ruppert, László; Heim, Bettina; Gunthner, Kevin; Usenko, Vladyslav C.; Elser, Dominique; Marquardt, Christoph; Filip, Radim; Leuchs, Gerd

    2016-10-01

    Continuous-variable quantum key distribution is a practical application of quantum information theory that is aimed at generation of secret cryptographic key between two remote trusted parties and that uses multi-photon quantum states as carriers of key bits. Remote parties share the secret key via a quantum channel, that presumably is under control of of an eavesdropper, and which properties must be taken into account in the security analysis. Well-studied fiber-optical quantum channels commonly possess stable transmittance and low noise levels, while free-space channels represent a simpler, less demanding and more flexible alternative, but suffer from atmospheric effects such as turbulence that in particular causes a non-uniform transmittance distribution referred to as fading. Nonetheless free-space channels, providing an unobstructed line-of-sight, are more apt for short, mid-range and potentially long-range (using satellites) communication and will play an important role in the future development and implementation of QKD networks. It was previously theoretically shown that coherent-state CV QKD should be in principle possible to implement over a free-space fading channel, but strong transmittance fluctuations result in the significant modulation-dependent channel excess noise. In this regime the post-selection of highly transmitting sub-channels may be needed, which can even restore the security of the protocol in the strongly turbulent channels. We now report the first proof-of-principle experimental test of coherent state CV QKD protocol using different levels Gaussian modulation over a mid-range (1.6-kilometer long) free-space atmospheric quantum channel. The transmittance of the link was characterized using intensity measurements for the reference but channel estimation using the modulated coherent states was also studied. We consider security against Gaussian collective attacks, that were shown to be optimal against CV QKD protocols . We assumed a

  19. Bio-Social Variables as Predictors of Teacher Union Leaders' Adherence to Democratic Principles in Ogun State, Nigeria

    ERIC Educational Resources Information Center

    Fejoh, Johnson

    2016-01-01

    This study investigated the influence of bio-social variables - educational status, age and family socio-economic background on teacher union leaders' adherence to democratic principles in Ogun State of Nigeria. The study employed the ex-post-facto research design. Five hypotheses were generated and tested using an instrument titled "union…

  20. Tissue engineering and stem cells: basic principles and applications in urology.

    PubMed

    Shokeir, Ahmed A; Harraz, Ahmed M; El-Din, Ahmed B Shehab

    2010-12-01

    To overcome problems of damaged urinary tract tissues and complications of current procedures, tissue engineering (TE) techniques and stem cell (SC) research have achieved great progress. Although diversity of techniques is used, urologists should know the basics. We carried out a literature review regarding the basic principles and applications of TE and SC technologies in the genitourinary tract. We carried out MEDLINE/PubMed searches for English articles until March 2010 using a combination of the following keywords: bladder, erectile dysfunction, kidney, prostate, Peyronie's disease, stem cells, stress urinary incontinence, testis, tissue engineering, ureter, urethra and urinary tract. Retrieved abstracts were checked, and full versions of relevant articles were obtained. Scientists have achieved great advances in basic science research. This is obvious by the tremendous increase in the number of publications. We divided this review in two topics; the first discusses basic science principles of TE and SC, whereas the second part delineates current clinical applications and advances in urological literature. TE and SC applications represent an alternative resource for treating complicated urological diseases. Despite the paucity of clinical trials, the promising results of animal models and continuous work represents the hope of treating various urological disorders with this technology.

  1. Al embedded MgO barrier MTJ: A first principle study for application in fast and compact STT-MRAMs

    NASA Astrophysics Data System (ADS)

    Yadav, Manoj Kumar; Gupta, Santosh Kumar; Rai, Sanjeev; Pandey, Avinash C.

    2017-03-01

    The first principle comparative study of a novel single Al sheet embedded MgO and pure MgO barrier having Fe electrodes magnetic tunnel junction has been presented. Al embedded MgO is reported to provide enhanced spin polarised tunnelling current due to increase of spin-polarized density of states at Fermi energy in the barrier region. This novel MTJ provides a current density and resistance area (RA) product of 94.497 ×107 A / cm2 and 0.105  Ω - μm2 respectively. With such a low RA product; it allows higher deriving current due to which switching time of magnetization reversal reduces without inducing barrier related breakdowns in non-volatile magnetic random access memories. The low RA product and high current density of the proposed MTJ may have possible applications in integration with existing MOS circuits.

  2. Passivation for Cu2ZnSnS4/WZ-ZnO interface states: From the first principles calculations

    NASA Astrophysics Data System (ADS)

    Cheng, Yu-Wen; Tang, Fu-Ling; Xue, Hong-Tao; Liu, Hong-Xia; Gao, Bo

    2017-02-01

    We employed the first-principles calculations to investigate F, Cl and H's passivation effects for Cu2ZnSnS4 (102)/WZ-ZnO (110) interface, in which the interface states mainly originate from Sn atoms. The interface states peaks can be reduced more or less by introducing F, Cl and H around Sn atom. H and F have a more efficient passivation effect than Cl atoms. The charge density difference and Bader atomic charge analysis suggests that F, Cl and H can get part of the electrons leading to interface states and that the interface states can be passivated by F, Cl or H atoms.

  3. Practical Application of Principle-Agent and Auction Theory: A Contracting Guide

    DTIC Science & Technology

    2015-05-01

    Capt Will Griffin C1C Ryan Holler C1C Jimmy Manuel C1C Ryan McVay Practical Application of Principle-Agent and Auction Theory: A Contracting... Auction Theory: A Contracting Guide 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER...Statement of the Problem  The DOD holds an inferior position when bargaining with the private sector (known budget). This creates inefficiencies in

  4. Molecular diagnosis of B- and T-cell lymphomas: fundamental principles and clinical applications.

    PubMed

    Rezuke, W N; Abernathy, E C; Tsongalis, G J

    1997-10-01

    Molecular diagnostic assays have become routine in the evaluation of lymphoid malignancies. Both Southern transfer and polymerase chain reaction (PCR) technologies are used to assess for B- and T-cell clonality, the presence of rearrangements involving protooncogenes such as bcl-1 and bcl-2, and the monitoring of minimal residual disease. We review the fundamentals of B- and T-cell ontogeny as well as the basic principles of the Southern transfer and PCR assays and their applications to the diagnosis of lymphoid malignancies.

  5. Application of marketing principles to improve participation in public health program.

    PubMed

    Alexander, K; McCullough, J

    1981-01-01

    The application of marketing principles to develop a program aimed at increasing participation in a cervical screening program appears to be more effective than the use of sales techniques. Standard methods of promotion such as posters, direct mail, and flyers were generally ineffective. Direct personal contact produced the majority of program participants, and mass media approaches also resulted in significant participant response. A consumer orientation led to development of effective program features designed to satisfy specific consumer needs. Use of female health practitioners, for example, reduced cultural barriers to participation and insured adequate screening in Mexican-American populations.

  6. Genetics and psychiatry: a proposal for the application of the precautionary principle.

    PubMed

    Porteri, Corinna

    2013-08-01

    The paper suggests an application of the precautionary principle to the use of genetics in psychiatry focusing on scientific uncertainty. Different levels of uncertainty are taken into consideration--from the acknowledgement that the genetic paradigm is only one of the possible ways to explain psychiatric disorders, via the difficulties related to the diagnostic path and genetic methods, to the value of the results of studies carried out in this field. Considering those uncertainties, some measures for the use of genetics in psychiatry are suggested. Some of those measures are related to the conceptual limits of the genetic paradigm; others are related to present knowledge and should be re-evaluated.

  7. Generalization of the variational principle and the Hohenberg and Kohn theorems for excited states of Fermion systems

    NASA Astrophysics Data System (ADS)

    Gonis, A.

    2017-01-01

    Through the entanglement of a collection of K non-interacting replicas of a system of N interacting Fermions, and making use of the properties of reduced density matrices the variational principle and the theorems of Hohenberg and Kohn are generalized to excited states. The generalization of the variational principle makes use of the natural orbitals of an N-particle density matrix describing the state of lowest energy of the entangled state. The extension of the theorems of Hohenberg and Kohn is based on the ground-state formulation of density functional theory but with a new interpretation of the concept of a ground state: It is the state of lowest energy of a system of KN Fermions that is described in terms of the excited states of the N-particle interacting system. This straightforward implementation of the line of reasoning of ground-state density functional theory to a new domain leads to a unique and logically valid extension of the theory to excited states that allows the systematic treatment of all states in the spectrum of the Hamiltonian of an interacting system.

  8. Application of the principle of breaking ocean waves to mixing technology

    NASA Astrophysics Data System (ADS)

    Doman, Michael

    1991-05-01

    Turbulent mixing in the multiphase system of breaking ocean waves and whitecaps is known to play an important role in the mass exchange between ocean and atmosphere. Thus engineering applications to this naturally occurring dynamic exchange process appear to be of interest in various areas of applied mixing technology. Starting from the fact that ocean waves break after having reached their point of instability, a three-dimensional collapsible swivel mechanism (CSM) was developed for simulating by mechanical means the highly dynamic movement of breaking ocean waves. The CSM, employing reversion kinematics of a six-link spatial kinematic chain, has been realized in the construction of a new mixing technology (called swing mixer) that can either move the fluid by the use of mixing tools in a vessel (stirrer principle) or by moving the entire vessel (shaker principle). A first description of swing mixers has recently been given.1 A special characteristic of swing mixers is their three-dimensional reversing motion, the forward and backward paths being nonsuperimposable mirror images of one another. During the mixing process in swing mixers, the efficient mixing principle of repeated stretching and folding2 also takes place in the third dimension. Details of the mixing technology of swing mixers will be discussed together with some suggestions as to how spatial and temporal changes in the concentration may be determined with the help of CCD cameras in a given multiphase system agitated by swing mixers.

  9. Application of Just War principles to nuclear war and deterrence in three contemporary theorists: Michael Walzer, Paul Ramsey, and William V. O'Brien

    SciTech Connect

    Sichol, M.W.

    1984-01-01

    The purpose of this study is to show that the Just War tradition remains applicable in the nuclear age; three contemporary just war theorists have been selected to show that this is the case: Michael Walzer, political theorist; Paul Ramsey, theologian, and William V. O'Brien, professor of international law. Each is also influenced by his Jewish, Protestant and Roman catholic tradition respectively. The focus is on the principles of proportionality and discrimination, showing how the three theorists define, validate, and apply these principles to the conduct of war as compared to the concepts of the classic Just War theorists and to those expressed in the 1983 US Catholic Bishops' Statement. This Statement reflects the influence of the three secular theorists and also of contemporary moral theory. Just War principles are applied to the uses of nuclear weapons in war-fighting and deterrence and to actual public policy. Just War principles provide policy makers with a moral basis to move beyond national egoism by directing them to be concerned about the needs of the person and about the interdependence among states principles whose validity has often been assumed but whose application has never been so necessary.

  10. Solid State Marx Modulators for Emerging Applications

    SciTech Connect

    Kemp, M.A.; /SLAC

    2012-09-14

    Emerging linear accelerator applications increasingly push the boundaries of RF system performance and economics. The power modulator is an integral part of RF systems whose characteristics play a key role in the determining parameters such as efficiency, footprint, cost, stability, and availability. Particularly within the past decade, solid-state switch based modulators have become the standard in high-performance, high power modulators. One topology, the Marx modulator, has characteristics which make it particularly attractive for several emerging applications. This paper is an overview of the Marx topology, some recent developments, and a case study of how this architecture can be applied to a few proposed linear accelerators.

  11. The Stampacchia maximum principle for stochastic partial differential equations and applications

    NASA Astrophysics Data System (ADS)

    Chekroun, Mickaël D.; Park, Eunhee; Temam, Roger

    2016-02-01

    Stochastic partial differential equations (SPDEs) are considered, linear and nonlinear, for which we establish comparison theorems for the solutions, or positivity results a.e., and a.s., for suitable data. Comparison theorems for SPDEs are available in the literature. The originality of our approach is that it is based on the use of truncations, following the Stampacchia approach to maximum principle. We believe that our method, which does not rely too much on probability considerations, is simpler than the existing approaches and to a certain extent, more directly applicable to concrete situations. Among the applications, boundedness results and positivity results are respectively proved for the solutions of a stochastic Boussinesq temperature equation, and of reaction-diffusion equations perturbed by a non-Lipschitz nonlinear noise. Stabilization results to a Chafee-Infante equation perturbed by a nonlinear noise are also derived.

  12. Uncertainty quantification in application of the enrichment meter principle for nondestructive assay of special nuclear material

    DOE PAGES

    Burr, Tom; Croft, Stephen; Jarman, Kenneth D.

    2015-09-05

    The various methods of nondestructive assay (NDA) of special nuclear material (SNM) have applications in nuclear nonproliferation, including detection and identification of illicit SNM at border crossings, and quantifying SNM at nuclear facilities for safeguards. No assay method is complete without “error bars,” which provide one way of expressing confidence in the assay result. Consequently, NDA specialists typically quantify total uncertainty in terms of “random” and “systematic” components, and then specify error bars for the total mass estimate in multiple items. Uncertainty quantification (UQ) for NDA has always been important, but it is recognized that greater rigor is needed andmore » achievable using modern statistical methods. To this end, we describe the extent to which the guideline for expressing uncertainty in measurements (GUM) can be used for NDA. Also, we propose improvements over GUM for NDA by illustrating UQ challenges that it does not address, including calibration with errors in predictors, model error, and item-specific biases. A case study is presented using low-resolution NaI spectra and applying the enrichment meter principle to estimate the U-235 mass in an item. The case study illustrates how to update the current American Society for Testing and Materials guide for application of the enrichment meter principle using gamma spectra from a NaI detector.« less

  13. Uncertainty quantification in application of the enrichment meter principle for nondestructive assay of special nuclear material

    SciTech Connect

    Burr, Tom; Croft, Stephen; Jarman, Kenneth D.

    2015-09-05

    The various methods of nondestructive assay (NDA) of special nuclear material (SNM) have applications in nuclear nonproliferation, including detection and identification of illicit SNM at border crossings, and quantifying SNM at nuclear facilities for safeguards. No assay method is complete without “error bars,” which provide one way of expressing confidence in the assay result. Consequently, NDA specialists typically quantify total uncertainty in terms of “random” and “systematic” components, and then specify error bars for the total mass estimate in multiple items. Uncertainty quantification (UQ) for NDA has always been important, but it is recognized that greater rigor is needed and achievable using modern statistical methods. To this end, we describe the extent to which the guideline for expressing uncertainty in measurements (GUM) can be used for NDA. Also, we propose improvements over GUM for NDA by illustrating UQ challenges that it does not address, including calibration with errors in predictors, model error, and item-specific biases. A case study is presented using low-resolution NaI spectra and applying the enrichment meter principle to estimate the U-235 mass in an item. The case study illustrates how to update the current American Society for Testing and Materials guide for application of the enrichment meter principle using gamma spectra from a NaI detector.

  14. Applications Analysis: Principles and Examples from Various Distributed Computer Applications at Sandia National Laboratories New Mexico

    SciTech Connect

    Bateman, Dennis; Evans, David; Jensen, Dal; Nelson, Spencer

    1999-08-01

    As information systems have become distributed over many computers within the enterprise, managing those applications has become increasingly important. This is an emerging area of work, recognized as such by many large organizations as well as many start-up companies. In this report, we present a summary of the move to distributed applications, some of the problems that came along for the ride, and some specific examples of the tools and techniques we have used to analyze distributed applications and gain some insight into the mechanics and politics of distributed computing.

  15. First-Principles-Based Method for Electron Localization: Application to Monolayer Hexagonal Boron Nitride.

    PubMed

    Ekuma, C E; Dobrosavljević, V; Gunlycke, D

    2017-03-10

    We present a first-principles-based many-body typical medium dynamical cluster approximation and density function theory method for characterizing electron localization in disordered structures. This method applied to monolayer hexagonal boron nitride shows that the presence of boron vacancies could turn this wide-gap insulator into a correlated metal. Depending on the strength of the electron interactions, these calculations suggest that conduction could be obtained at a boron vacancy concentration as low as 1.0%. We also explore the distribution of the local density of states, a fingerprint of spatial variations, which allows localized and delocalized states to be distinguished. The presented method enables the study of disorder-driven insulator-metal transitions not only in h-BN but also in other physical materials.

  16. First-Principles-Based Method for Electron Localization: Application to Monolayer Hexagonal Boron Nitride

    NASA Astrophysics Data System (ADS)

    Ekuma, C. E.; Dobrosavljević, V.; Gunlycke, D.

    2017-03-01

    We present a first-principles-based many-body typical medium dynamical cluster approximation and density function theory method for characterizing electron localization in disordered structures. This method applied to monolayer hexagonal boron nitride shows that the presence of boron vacancies could turn this wide-gap insulator into a correlated metal. Depending on the strength of the electron interactions, these calculations suggest that conduction could be obtained at a boron vacancy concentration as low as 1.0%. We also explore the distribution of the local density of states, a fingerprint of spatial variations, which allows localized and delocalized states to be distinguished. The presented method enables the study of disorder-driven insulator-metal transitions not only in h -BN but also in other physical materials.

  17. Real processing (RP) I: The principle of minimal entropy production (PME) of irreversible thermodynamics and the principle of minimal deformation (PMD) of hydrodynamics, their dependence and applications

    NASA Astrophysics Data System (ADS)

    Reiser, Bernhard

    1996-02-01

    The principle of minimal entropy production (PME) of irreversible thermodynamics is generalized to determine process parameters in process engineering with well-known mathematical methods. This useful instrument applied to industrial processes is called real processing (RP). A special form of the PME is the principle of minimal deformation (PMD) which allows for applications in hydrodynamics (HD). A second and independent derivation of the PMD takes a similar way as the derivation of the statement of Helmholtz and Rayleigh (SHR). The generalization of SHR then leads to the PMD derived within HD. Next in a similar way. starting directly from the Navier-Stokes equation (NSE) can lead in a third way to the PMD. Several applications of the PMD are given: An analytical and numerical application of PMD is given for the entrance flow of tubes. Physical and analytical applications are the Crocco-Vazsonyi-type equations opening new possibilities of analytical treatment of process engineering problems. Process engineering models may be replaced by applications of PMD. In particular, turbulence may be treated as the answer of nature on PMD. A basic mathematical treatment of these subjects is possible by the gradient field theory (GFT), a particular method of vector analysis stemming from the Clebsch Ansatz for vector fields, which can be ordered from the author together with an advanced detailed mathematical treatment of these subjects.

  18. A mathematical structure of the separated variational principles of steady states for multi-forces and multi-currents

    NASA Astrophysics Data System (ADS)

    Okada, Kanzo

    2017-03-01

    Separated variational principles of steady states for multi-forces and multi-currents in transport phenomena were recently proposed by Suzuki (Suzuki, 2013) by extending the principle of minimum integrated entropy production for a single force found by the same author (Suzuki, 2013). On the other hand, in non-equilibrium thermodynamics, Edelen (Edelen, 1974) generalized the linear Onsager theory to those irreversible processes with significant thermodynamic forces by means of Onsager fluxes. Onsager fluxes by definition satisfy a nonlinear system of reciprocity relations, vanish in thermodynamic equilibrium, and satisfy the second law of thermodynamics. Each system of Onsager fluxes is derivable from a dissipation potential sometimes called the flux potential. This paper aims to elucidate a mathematical structure of the separated variational principles based on the above work of Edelen.

  19. The biological default state of cell proliferation with variation and motility, a fundamental principle for a theory of organisms.

    PubMed

    Soto, Ana M; Longo, Giuseppe; Montévil, Maël; Sonnenschein, Carlos

    2016-10-01

    The principle of inertia is central to the modern scientific revolution. By postulating this principle Galileo at once identified a pertinent physical observable (momentum) and a conservation law (momentum conservation). He then could scientifically analyze what modifies inertial movement: gravitation and friction. Inertia, the default state in mechanics, represented a major theoretical commitment: there is no need to explain uniform rectilinear motion, rather, there is a need to explain departures from it. By analogy, we propose a biological default state of proliferation with variation and motility. From this theoretical commitment, what requires explanation is proliferative quiescence, lack of variation, lack of movement. That proliferation is the default state is axiomatic for biologists studying unicellular organisms. Moreover, it is implied in Darwin's "descent with modification". Although a "default state" is a theoretical construct and a limit case that does not need to be instantiated, conditions that closely resemble unrestrained cell proliferation are readily obtained experimentally. We will illustrate theoretical and experimental consequences of applying and of ignoring this principle.

  20. 8 CFR 343b.4 - Applicant outside of United States.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Applicant outside of United States. 343b.4... CERTIFICATE OF NATURALIZATION FOR RECOGNITION BY A FOREIGN STATE § 343b.4 Applicant outside of United States. If the application is received by a DHS office outside the United States, an officer will,...

  1. Principles and applications of hyperspectral imaging in quality evaluation of agro-food products: a review.

    PubMed

    Elmasry, Gamal; Kamruzzaman, Mohammed; Sun, Da-Wen; Allen, Paul

    2012-01-01

    The requirements of reliability, expeditiousness, accuracy, consistency, and simplicity for quality assessment of food products encouraged the development of non-destructive technologies to meet the demands of consumers to obtain superior food qualities. Hyperspectral imaging is one of the most promising techniques currently investigated for quality evaluation purposes in numerous sorts of applications. The main advantage of the hyperspectral imaging system is its aptitude to incorporate both spectroscopy and imaging techniques not only to make a direct assessment of different components simultaneously but also to locate the spatial distribution of such components in the tested products. Associated with multivariate analysis protocols, hyperspectral imaging shows a convinced attitude to be dominated in food authentication and analysis in future. The marvellous potential of the hyperspectral imaging technique as a non-destructive tool has driven the development of more sophisticated hyperspectral imaging systems in food applications. The aim of this review is to give detailed outlines about the theory and principles of hyperspectral imaging and to focus primarily on its applications in the field of quality evaluation of agro-food products as well as its future applicability in modern food industries and research.

  2. Efficient quantum optical state engineering and applications

    NASA Astrophysics Data System (ADS)

    McCusker, Kevin T.

    Over a century after the modern prediction of the existence of individual particles of light by Albert Einstein, a reliable source of this simple quantum state of one photon does not exist. While common light sources such as a light bulb, LED, or laser can produce a pulse of light with an average of one photon, there is (currently) no way of knowing the number of photons in that pulse without first absorbing (and thereby destroying) them. Spontaneous parametric down-conversion, a process in which one high-energy photon splits into two lower-energy photons, allows us to prepare a single-photon state by detecting one of the photons, which then heralds the existence of its twin. This process has been the workhorse of quantum optics, allowing demonstrations of a myriad of quantum processes and protocols, such as entanglement, cryptography, superdense coding, teleportation, and simple quantum computing demonstrations. All of these processes would benefit from better engineering of the underlying down-conversion process, but despite significant effort (both theoretical and experimental), optimization of this process is ongoing. The focus of this work is to optimize certain aspects of a down-conversion source, and then use this tool in novel experiments not otherwise feasible. Specifically, the goal is to optimize the heralding efficiency of the down-conversion photons, i.e., the probability that if one photon is detected, the other photon is also detected. This source is then applied to two experiments (a single-photon source, and a quantum cryptography implementation), and the detailed theory of an additional application (a source of Fock states and path-entangled states, called N00N states) is discussed, along with some other possible applications.

  3. First-principles calculation of ground and excited-state absorption spectra of ruby and alexandrite considering lattice relaxation

    NASA Astrophysics Data System (ADS)

    Watanabe, Shinta; Sasaki, Tomomi; Taniguchi, Rie; Ishii, Takugo; Ogasawara, Kazuyoshi

    2009-02-01

    We performed first-principles calculations of multiplet structures and the corresponding ground-state absorption and excited-state absorption spectra for ruby (Cr3+:α-Al2O3) and alexandrite (Cr3+:BeAl2O4) which included lattice relaxation. The lattice relaxation was estimated using the first-principles total energy and molecular-dynamics method of the CASTEP code. The multiplet structure and absorption spectra were calculated using the configuration-interaction method based on density-functional calculations. For both ruby and alexandrite, the theoretical absorption spectra, which were already in reasonable agreement with experimental spectra, were further improved by consideration of lattice relaxation. In the case of ruby, the peak positions and peak intensities were improved through the use of models with relaxations of 11 or more atoms. For alexandrite, the polarization dependence of the U band was significantly improved, even by a model with a relaxation of only seven atoms.

  4. [Principles and applications of hyperspectral imaging technique in quality and safety inspection of fruits and vegetables].

    PubMed

    Zhang, Bao-Hua; Li, Jiang-Bo; Fan, Shu-Xiang; Huang, Wen-Qian; Zhang, Chi; Wang Qing-Yan; Xiao, Guang-Dong

    2014-10-01

    The quality and safety of fruits and vegetables are the most concerns of consumers. Chemical analytical methods are traditional inspection methods which are time-consuming and labor intensive destructive inspection techniques. With the rapid development of imaging technique and spectral technique, hyperspectral imaging technique has been widely used in the nondestructive inspection of quality and safety of fruits and vegetables. Hyperspectral imaging integrates the advantages of traditional imaging and spectroscopy. It can obtain both spatial and spectral information of inspected objects. Therefore, it can be used in either external quality inspection as traditional imaging system, or internal quality or safety inspection as spectroscopy. In recent years, many research papers about the nondestructive inspection of quality and safety of fruits and vegetables by using hyperspectral imaging have been published, and in order to introduce the principles of nondestructive inspection and track the latest research development of hyperspectral imaging in the nondestructive inspection of quality and safety of fruits and vegetables, this paper reviews the principles, developments and applications of hyperspectral imaging in the external quality, internal quality and safety inspection of fruits and vegetables. Additionally, the basic components, analytical methods, future trends and challenges are also reported or discussed in this paper.

  5. Application of photon detectors in the VIP2 experiment to test the Pauli Exclusion Principle

    NASA Astrophysics Data System (ADS)

    Pichler, A.; Bartalucci, S.; Bazzi, M.; Bertolucci, S.; Berucci, C.; Bragadireanu, M.; Cargnelli, M.; Clozza, A.; Curceanu, C.; De Paolis, L.; Di Matteo, S.; D'Ufflzi, A.; Egger, J.-P.; Guaraldo, C.; Iliescu, M.; Ishiwatari, T.; Laubenstein, M.; Marton, J.; Milotti, E.; Pietreanu, D.; Piscicchia, K.; Ponta, T.; Sbardella, E.; Scordo, A.; Shi, H.; Sirghi, D.; Sirghi, F.; Sperandio, L.; Vazquez-Doce, O.; Widmann, E.; Zmeskal, J.

    2016-05-01

    The Pauli Exclusion Principle (PEP) was introduced by the austrian physicist Wolfgang Pauli in 1925. Since then, several experiments have checked its validity. From 2006 until 2010, the VIP (Violation of the Pauli Principle) experiment took data at the LNGS underground laboratory to test the PEP. This experiment looked for electronic 2p to Is transitions in copper, where 2 electrons are in the Is state before the transition happens. These transitions violate the PEP. The lack of detection of X-ray photons coming from these transitions resulted in a preliminary upper limit for the violation of the PEP of 4.7 × 10-29. Currently, the successor experiment VIP2 is under preparation. The main improvements are, on one side, the use of Silicon Drift Detectors (SDDs) as X-ray photon detectors. On the other side an active shielding is implemented, which consists of plastic scintillator bars read by Silicon Photomultipliers (SiPMs). The employment of these detectors will improve the upper limit for the violation of the PEP by around 2 orders of magnitude.

  6. Equivalence principles and electromagnetism

    NASA Technical Reports Server (NTRS)

    Ni, W.-T.

    1977-01-01

    The implications of the weak equivalence principles are investigated in detail for electromagnetic systems in a general framework. In particular, it is shown that the universality of free-fall trajectories (Galileo weak equivalence principle) does not imply the validity of the Einstein equivalence principle. However, the Galileo principle plus the universality of free-fall rotation states does imply the Einstein principle.

  7. GRE T2∗-Weighted MRI: Principles and Clinical Applications

    PubMed Central

    Tang, Meng Yue; Chen, Tian Wu; Zhang, Xiao Ming; Huang, Xiao Hua

    2014-01-01

    The sequence of a multiecho gradient recalled echo (GRE) T2*-weighted imaging (T2*WI) is a relatively new magnetic resonance imaging (MRI) technique. In contrast to T2 relaxation, which acquires a spin echo signal, T2* relaxation acquires a gradient echo signal. The sequence of a GRE T2*WI requires high uniformity of the magnetic field. GRE T2*WI can detect the smallest changes in uniformity in the magnetic field and can improve the rate of small lesion detection. In addition, the T2* value can indirectly reflect changes in tissue biochemical components. Moreover, it can be used for the early diagnosis and quantitative diagnosis of some diseases. This paper reviews the principles and clinical applications as well as the advantages and disadvantages of GRE T2*WI. PMID:24987676

  8. Microfluidic Surface Plasmon Resonance Sensors: From Principles to Point-of-Care Applications

    PubMed Central

    Wang, Da-Shin; Fan, Shih-Kang

    2016-01-01

    Surface plasmon resonance (SPR) is a label-free, highly-sensitive, and real-time sensing technique. Conventional SPR sensors, which involve a planar thin gold film, have been widely exploited in biosensing; various miniaturized formats have been devised for portability purposes. Another type of SPR sensor which utilizes localized SPR (LSPR), is based on metal nanostructures with surface plasmon modes at the structural interface. The resonance condition is sensitive to the refractive index change of the local medium. The principles of these two types of SPR sensors are reviewed and their integration with microfluidic platforms is described. Further applications of microfluidic SPR sensors to point-of-care (POC) diagnostics are discussed. PMID:27472340

  9. Toward Integrated Molecular Diagnostic System (iMDx): Principles and Applications

    PubMed Central

    Park, Seung-min; Sabour, Andrew F.; Son, Jun Ho; Lee, Sang Hun

    2014-01-01

    Integrated molecular diagnostic systems (iMDx), which are automated, sensitive, specific, user-friendly, robust, rapid, easy-to-use, and portable, can revolutionize future medicine. This review will first focus on the components of sample extraction, preservation, and filtration necessary for all point-of-care devices to include for practical use. Subsequently, we will look for low-powered and precise methods for both sample amplification and signal transduction, going in-depth to the details behind their principles. The final field of total device integration and its application to the clinical field will also be addressed to discuss the practicality for future patient care. We envision that microfluidic systems hold the potential to breakthrough the number of problems brought into the field of medical diagnosis today. PMID:24759281

  10. The principle of commonality and its application to the Space Station Freedom Program

    NASA Technical Reports Server (NTRS)

    Hopson, George D.; Thomas, L. Dale; Daniel, Charles C.

    1989-01-01

    The principle of commonality has achieved wide application in the communication, automotive, and aircraft industries. By the use of commonality, component development costs are minimized, logistics are simplified, and the investment costs of spares inventory are reduced. With space systems, which must be maintained and repaired in orbit, the advantages of commonality are compounded. Transportation of spares is expensive, on-board storage volume for spares is limited, and crew training and special tools needed for maintenance and repair are significant considerations. This paper addresses the techniques being formulated to realize the benefits of commonality in the design of the systems and elements of the Space Station Freedom Program, and include the criteria for determining the extent of commonality to be implemented.

  11. Microfluidic Surface Plasmon Resonance Sensors: From Principles to Point-of-Care Applications.

    PubMed

    Wang, Da-Shin; Fan, Shih-Kang

    2016-07-27

    Surface plasmon resonance (SPR) is a label-free, highly-sensitive, and real-time sensing technique. Conventional SPR sensors, which involve a planar thin gold film, have been widely exploited in biosensing; various miniaturized formats have been devised for portability purposes. Another type of SPR sensor which utilizes localized SPR (LSPR), is based on metal nanostructures with surface plasmon modes at the structural interface. The resonance condition is sensitive to the refractive index change of the local medium. The principles of these two types of SPR sensors are reviewed and their integration with microfluidic platforms is described. Further applications of microfluidic SPR sensors to point-of-care (POC) diagnostics are discussed.

  12. Introduction to the application of QbD principles for the development of monoclonal antibodies.

    PubMed

    Finkler, Christof; Krummen, Lynne

    2016-09-01

    Quality by Design (QbD) is a global regulatory initiative with the goal of enhancing pharmaceutical development through the proactive design of pharmaceutical manufacturing process and controls to consistently deliver the intended performance of the product. The principles of pharmaceutical development relevant to QbD are described in the ICH guidance documents (ICHQ8-11). An integrated set of risk assessments and their related elements developed at Roche/Genentech were designed to provide an overview of product and process knowledge for the production of a recombinant monoclonal antibody. This chapter introduces a publication series on the application of Quality by Design for biopharmaceuticals, with a focus on the development of recombinant monoclonal antibodies. The development of and overview on the QbD concept applied by Roche and Genentech is described and essential QbD elements are presented.

  13. Multivariate statistical analysis: Principles and applications to coorbital streams of meteorite falls

    NASA Technical Reports Server (NTRS)

    Wolf, S. F.; Lipschutz, M. E.

    1993-01-01

    Multivariate statistical analysis techniques (linear discriminant analysis and logistic regression) can provide powerful discrimination tools which are generally unfamiliar to the planetary science community. Fall parameters were used to identify a group of 17 H chondrites (Cluster 1) that were part of a coorbital stream which intersected Earth's orbit in May, from 1855 - 1895, and can be distinguished from all other H chondrite falls. Using multivariate statistical techniques, it was demonstrated that a totally different criterion, labile trace element contents - hence thermal histories - or 13 Cluster 1 meteorites are distinguishable from those of 45 non-Cluster 1 H chondrites. Here, we focus upon the principles of multivariate statistical techniques and illustrate their application using non-meteoritic and meteoritic examples.

  14. Cross-cultural medical education in the United States: key principles and experiences.

    PubMed

    Betancourt, Joseph R; Cervantes, Marina C

    2009-09-01

    The field of cross-cultural care focuses on the ability to communicate effectively and provide quality health care to patients from diverse sociocultural backgrounds. In recent years, medical schools in the United States have increasingly recognized the growing importance of incorporating cross-cultural curricula into medical education. Cross-cultural medical education in the United States has emerged for four reasons: (1) the need for providers to have the skills to care for a diverse patient population; (2) the link between effective communication and health outcomes; (3) the presence of racial/ethnic disparities that are, in part, due to poor communication across cultures; and (4) medical school accreditation requirements. There are three major approaches to cross-cultural education: (1) the cultural sensitivity/awareness approach that focuses on attitudes; (2) the multicultural/categorical approach that focuses on knowledge; and (3) the cross-cultural approach that focuses on skills. The patient-based approach to cross-cultural care combines these three concepts into a framework that can be used to care for any patient, anytime, anywhere. Ultimately, if cross-cultural medical education is to evolve, students must believe it is important and understand that the categorical approach can lead to stereotyping; it should be taught using patient cases and highlighting clinical applications; it should be embedded in a longitudinal, developmentally appropriate fashion; and it should be integrated into the larger curriculum whenever possible. At the Harvard Medical School, we have tried to apply all of these lessons to our work, and we have started to develop a strategic integration process where we try to raise awareness, impart knowledge, and teach cross-cultural skills over the 4 years of schooling.

  15. An Automated Application Framework to Model Disordered Materials Based on a High Throughput First Principles Approach

    NASA Astrophysics Data System (ADS)

    Oses, Corey; Yang, Kesong; Curtarolo, Stefano; Duke Univ Collaboration; UC San Diego Collaboration

    Predicting material properties of disordered systems remains a long-standing and formidable challenge in rational materials design. To address this issue, we introduce an automated software framework capable of modeling partial occupation within disordered materials using a high-throughput (HT) first principles approach. At the heart of the approach is the construction of supercells containing a virtually equivalent stoichiometry to the disordered material. All unique supercell permutations are enumerated and material properties of each are determined via HT electronic structure calculations. In accordance with a canonical ensemble of supercell states, the framework evaluates ensemble average properties of the system as a function of temperature. As proof of concept, we examine the framework's final calculated properties of a zinc chalcogenide (ZnS1-xSex), a wide-gap oxide semiconductor (MgxZn1-xO), and an iron alloy (Fe1-xCux) at various stoichiometries.

  16. Marginal Bidding: An Application of the Equimarginal Principle to Bidding in TAC SCM

    NASA Astrophysics Data System (ADS)

    Greenwald, Amy; Naroditskiy, Victor; Odean, Tyler; Ramirez, Mauricio; Sodomka, Eric; Zimmerman, Joe; Cutler, Clark

    We present a fast and effective bidding strategy for the Trading Agent Competition in Supply Chain Management (TAC SCM). In TAC SCM, manufacturers compete to procure computer parts from suppliers (the procurement problem), and then sell assembled computers to customers in reverse auctions (the bidding problem). This paper is concerned only with bidding, in which an agent must decide how many computers to sell and at what prices to sell them. We propose a greedy solution, Marginal Bidding, inspired by the Equimarginal Principle, which states that revenue is maximized among possible uses of a resource when the return on the last unit of the resource is the same across all areas of use. We show experimentally that certain variations of Marginal Bidding can compute bids faster than our ILP solution, which enables Marginal Bidders to consider future demand as well as current demand, and hence achieve greater revenues when knowledge of the future is valuable.

  17. Low-coherence enhanced backscattering: review of principles and applications for colon cancer screening

    NASA Astrophysics Data System (ADS)

    Kim, Young L.; Liu, Yang; Turzhitsky, Vladimir M.; Roy, Hemant K.; Wali, Ramesh K.; Subramanian, Hariharan; Pradhan, Prabhakar; Backman, Vadim

    2006-07-01

    The phenomenon of enhanced backscattering (EBS) of light, also known as coherent backscattering (CBS) of light, has been the object of intensive investigation in nonbiological media over the last two decades. However, there have been only a few attempts to explore EBS for tissue characterization and diagnosis. We have recently made progress in the EBS measurements in tissue by taking advantage of low spatial coherence illumination, which has led us to the development of low-coherence enhanced backscattering (LEBS) spectroscopy. In this work, we review the current state of research on LEBS. After a brief discussion of the basic principle of EBS and LEBS, we present an overview of the unique features of LEBS for tissue characterization, and show that LEBS enables depth-selective spectroscopic assessment of mucosal tissue. Then, we demonstrate the potential of LEBS spectroscopy for predicting the risk of colon carcinogenesis and colonoscopy-free screening for colorectal cancer (CRC).

  18. Principles of Public School Accounting. State Educational Records and Reports Series: Handbook II-B.

    ERIC Educational Resources Information Center

    Adams, Bert K.; And Others

    This handbook discusses the following primary aspects of school accounting: Definitions and principles; opening the general ledger; recording the approved budget; a sample month of transactions; the balance sheet, monthly, and annual reports; subsidiary journals; payroll procedures; cafeteria fund accounting; debt service accounting; construction…

  19. Industrial applications using BASF eco-efficiency analysis: perspectives on green engineering principles.

    PubMed

    Shonnard, David R; Kicherer, Andreas; Saling, Peter

    2003-12-01

    Life without chemicals would be inconceivable, but the potential risks and impacts to the environment associated with chemical production and chemical products are viewed critically. Eco-efficiency analysis considers the economic and life cycle environmental effects of a product or process, giving these equal weighting. The major elements of the environmental assessment include primary energy use, raw materials utilization, emissions to all media, toxicity, safety risk, and land use. The relevance of each environmental category and also for the economic versus the environmental impacts is evaluated using national emissions and economic data. The eco-efficiency analysis method of BASF is briefly presented, and results from three applications to chemical processes and products are summarized. Through these applications, the eco-efficiency analyses mostly confirm the 12 Principles listed in Anastas and Zimmerman (Environ. Sci. Technol. 2003, 37(5), 94A), with the exception that, in one application, production systems based on bio-based feedstocks were not the most eco-efficient as compared to those based on fossil resources. Over 180 eco-efficiency analyses have been conducted at BASF, and their results have been used to support strategic decision-making, marketing, research and development, and communication with external parties. Eco-efficiency analysis, as one important strategy and success factor in sustainable development, will continue to be a very strong operational tool at BASF.

  20. Lean principles and defense information technology acquisition: An investigation of the determinants of successful application

    NASA Astrophysics Data System (ADS)

    Haley, M.

    The purpose of this study was to investigate whether or not there have been successful applications of lean manufacturing principles in highly variable defense IT environments. Specifically, the study assessed if implementation of the lean philosophies by a defense organization yielded repeatable, predictable results in software release schedules reductions. Additionally, the study set out to determine what potential critical success factors (CSF's) were documented in the secondary data captured for each release, and extracted the variables used in the decision making for acceptability of fielding. In evaluating lean applicability to the high variability environment of USAF IT acquisitions, the research was conducted using non-experimental quantitative methods of archival secondary data. The sample for this case study was compiled from a USAF office that had implemented these techniques in pre-development, development and testing, and fielding phases. Based on the research data, acquisitionists and lean practitioners are inherently interconnected. Therefore, an understanding that critical success factors (CSFs) are integral to successful lean application in DoD IT acquisitions is crucial. Through a combination of synergistic alignments, plyometric CSFs were discovered to maximize the effects of each single CSF to produce rapid results in defense IT acquisitions. These include: (1) Enterprise Incorporation, (2) Team Trust, (3) Transformational Leadership, (4) Recursive Improvement, (5) Integrated Synergy, (6) Customer-Centric Culture and (7) Heuristic Communication.

  1. 28 CFR 104.42 - Applicable state law.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Applicable state law. 104.42 Section 104... OF 2001 Amount of Compensation for Eligible Claimants. § 104.42 Applicable state law. The phrase “to the extent recovery for such loss is allowed under applicable state law,” as used in the...

  2. Affinity monolith chromatography: A review of principles and recent analytical applications

    PubMed Central

    Pfaunmiller, Erika L.; Paulemond, Marie Laura; Dupper, Courtney M.; Hage, David S.

    2012-01-01

    Affinity monolith chromatography (AMC) is a type of liquid chromatography that uses a monolithic support and a biologically-related binding agent as a stationary phase. AMC is a powerful method for the selective separation, analysis or studies of specific target compounds in a sample. This review discusses the basic principles of AMC and recent developments or applications of this method, with particular emphasis being given to work that has appeared in the last five years. Various materials that have been used to prepare columns for AMC are examined, including organic monoliths, silica monoliths, agarose monoliths and cryogels. These supports have been used in AMC for formats that have ranged from traditional columns to disks, microcolumns and capillaries. Many binding agents have also been employed in AMC, such as antibodies, enzymes, proteins, lectins, immobilized metal-ions and dyes. Some applications that have been reported with these binding agents in AMC are bioaffinity chromatography, immunoaffinity chromatography or immunoextraction, immobilized metal-ion affinity chromatography, dye-ligand affinity chromatography, chiral separations and biointeraction studies. Examples are presented from fields that include analytical chemistry, pharmaceutical analysis, clinical testing and biotechnology. Current trends and possible future directions in AMC are also discussed. PMID:23187827

  3. T1ρ magnetic resonance: basic physics principles and applications in knee and intervertebral disc imaging

    PubMed Central

    Zhang, Qinwei; Li, Xiaojuan; Chen, Weitian; Ahuja, Anil; Yuan, Jing

    2015-01-01

    T1ρ relaxation time provides a new contrast mechanism that differs from T1- and T2-weighted contrast, and is useful to study low-frequency motional processes and chemical exchange in biological tissues. T1ρ imaging can be performed in the forms of T1ρ-weighted image, T1ρ mapping and T1ρ dispersion. T1ρ imaging, particularly at low spin-lock frequency, is sensitive to B0 and B1 inhomogeneity. Various composite spin-lock pulses have been proposed to alleviate the influence of field inhomogeneity so as to reduce the banding-like spin-lock artifacts. T1ρ imaging could be specific absorption rate (SAR) intensive and time consuming. Efforts to address these issues and speed-up data acquisition are being explored to facilitate wider clinical applications. This paper reviews the T1ρ imaging’s basic physic principles, as well as its application for cartilage imaging and intervertebral disc imaging. Compared to more established T2 relaxation time, it has been shown that T1ρ provides more sensitive detection of proteoglycan (PG) loss at early stages of cartilage degeneration. T1ρ has also been shown to provide more sensitive evaluation of annulus fibrosis (AF) degeneration of the discs. PMID:26807369

  4. First-principles prediction of new complex transition metal hydrides for high temperature applications.

    PubMed

    Nicholson, Kelly M; Sholl, David S

    2014-11-17

    Metal hydrides with high thermodynamic stability are desirable for high-temperature applications, such as those that require high hydrogen release temperatures or low hydrogen overpressures. First-principles calculations have been used previously to identify complex transition metal hydrides (CTMHs) for high temperature use by screening materials with experimentally known structures. Here, we extend our previous screening of CTMHs with a library of 149 proposed materials based on known prototype structures and charge balancing rules. These proposed materials are typically related to known materials by cation substitution. Our semiautomated, high-throughput screening uses density functional theory (DFT) and grand canonical linear programming (GCLP) methods to compute thermodynamic properties and phase diagrams: 81 of the 149 materials are found to be thermodynamically stable. We identified seven proposed materials that release hydrogen at higher temperatures than the associated binary hydrides and at high temperature, T > 1000 K, for 1 bar H2 overpressure. Our results indicate that there are many novel CTMH compounds that are thermodynamically stable, and the computed thermodynamic data and phase diagrams should be useful for selecting materials and operating parameters for high temperature metal hydride applications.

  5. A calculus of unnecessary echoes: application of management principles to health care.

    PubMed

    Waldman, J D; McCullough, G

    2002-01-01

    We studied the clinical utility of echocardiography in children and applied principles of business management to draw conclusions that are applicable to health care in general. A significant number (13% in this series) of expensive medical diagnostic tests could be avoided without harm to patients. Cost reduction in medicine is possible in many situations without compromising quality of care. Care pathways (i.e., practice guidelines or clinical algorithms) provide one useful modality. However, for the safety of patients, all cost reduction methods must start with practicing physicians (or involve them at conceptualization) and an escape clause must be available to the treating physician for the atypical patient. The analytic approach used--concurrent assessment of percentage cost, charge, and payor--is applicable to all components of the health care value chain. The use of "percentage of charges" as an indicator of collection effectiveness is unrealistic and should be changed to "percentage potential reimbursement" because health care is effectively a fixed-reimbursement industry rather than a system subject to standard microeconomic (supply and demand) forces. The current reimbursement structure provides conflicting incentives both to health care institutions and to providers, creating an insurmountable barrier to any effective incentive system. Colloquy between practicing physicians and experts in operations management will stimulate cost reduction and can optimize the delivery of health care.

  6. T1ρ magnetic resonance: basic physics principles and applications in knee and intervertebral disc imaging.

    PubMed

    Wáng, Yì-Xiáng J; Zhang, Qinwei; Li, Xiaojuan; Chen, Weitian; Ahuja, Anil; Yuan, Jing

    2015-12-01

    T1ρ relaxation time provides a new contrast mechanism that differs from T1- and T2-weighted contrast, and is useful to study low-frequency motional processes and chemical exchange in biological tissues. T1ρ imaging can be performed in the forms of T1ρ-weighted image, T1ρ mapping and T1ρ dispersion. T1ρ imaging, particularly at low spin-lock frequency, is sensitive to B0 and B1 inhomogeneity. Various composite spin-lock pulses have been proposed to alleviate the influence of field inhomogeneity so as to reduce the banding-like spin-lock artifacts. T1ρ imaging could be specific absorption rate (SAR) intensive and time consuming. Efforts to address these issues and speed-up data acquisition are being explored to facilitate wider clinical applications. This paper reviews the T1ρ imaging's basic physic principles, as well as its application for cartilage imaging and intervertebral disc imaging. Compared to more established T2 relaxation time, it has been shown that T1ρ provides more sensitive detection of proteoglycan (PG) loss at early stages of cartilage degeneration. T1ρ has also been shown to provide more sensitive evaluation of annulus fibrosis (AF) degeneration of the discs.

  7. 29 CFR 18.302 - Applicability of state law.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 1 2014-07-01 2013-07-01 true Applicability of state law. 18.302 Section 18.302 Labor... OFFICE OF ADMINISTRATIVE LAW JUDGES Rules of Evidence Presumptions § 18.302 Applicability of state law... State law supplies the rule of decision is determined in accordance with State law. Relevancy and...

  8. 32 CFR 1903.3 - State law applicable.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false State law applicable. 1903.3 Section 1903.3... AGENCY INSTALLATIONS § 1903.3 State law applicable. (a) Unless specifically addressed by the regulations... installation are governed by State law. State law that is now or may later be in effect is adopted and made...

  9. 36 CFR 1004.2 - State law applicable.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 3 2014-07-01 2014-07-01 false State law applicable. 1004.2... State law applicable. (a) Unless specifically addressed by regulations in this chapter, traffic and the... State law. State law that is now or may later be in effect is adopted and made a part of the...

  10. 36 CFR 1004.2 - State law applicable.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false State law applicable. 1004.2... State law applicable. (a) Unless specifically addressed by regulations in this chapter, traffic and the... State law. State law that is now or may later be in effect is adopted and made a part of the...

  11. 36 CFR 4.2 - State law applicable.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false State law applicable. 4.2... AND TRAFFIC SAFETY § 4.2 State law applicable. (a) Unless specifically addressed by regulations in this chapter, traffic and the use of vehicles within a park area are governed by State law. State...

  12. Structure-Based Virtual Screening for Drug Discovery: Principles, Applications and Recent Advances

    PubMed Central

    Lionta, Evanthia; Spyrou, George; Vassilatis, Demetrios K.; Cournia, Zoe

    2014-01-01

    Structure-based drug discovery (SBDD) is becoming an essential tool in assisting fast and cost-efficient lead discovery and optimization. The application of rational, structure-based drug design is proven to be more efficient than the traditional way of drug discovery since it aims to understand the molecular basis of a disease and utilizes the knowledge of the three-dimensional structure of the biological target in the process. In this review, we focus on the principles and applications of Virtual Screening (VS) within the context of SBDD and examine different procedures ranging from the initial stages of the process that include receptor and library pre-processing, to docking, scoring and post-processing of topscoring hits. Recent improvements in structure-based virtual screening (SBVS) efficiency through ensemble docking, induced fit and consensus docking are also discussed. The review highlights advances in the field within the framework of several success studies that have led to nM inhibition directly from VS and provides recent trends in library design as well as discusses limitations of the method. Applications of SBVS in the design of substrates for engineered proteins that enable the discovery of new metabolic and signal transduction pathways and the design of inhibitors of multifunctional proteins are also reviewed. Finally, we contribute two promising VS protocols recently developed by us that aim to increase inhibitor selectivity. In the first protocol, we describe the discovery of micromolar inhibitors through SBVS designed to inhibit the mutant H1047R PI3Kα kinase. Second, we discuss a strategy for the identification of selective binders for the RXRα nuclear receptor. In this protocol, a set of target structures is constructed for ensemble docking based on binding site shape characterization and clustering, aiming to enhance the hit rate of selective inhibitors for the desired protein target through the SBVS process. PMID:25262799

  13. Current State and Future Prospect of Applications of Elliptic Function to Electric Power Field

    NASA Astrophysics Data System (ADS)

    Kinoshita, Haruka; Watanabe, Kazuo

    The paper deals with the current state and future prospect of applications of elliptic function to the electric power and energy field. In particular, practical use of conformal mapping technology by elliptic function are introduced for electric power cables. Returning to Riemann's basic principle “thinking instead of calculation”, against the main current of numerical calculation, we have a new understanding of elliptic function analysis for the usefulness and the beautiful with simplicity and elegance.

  14. 2 CFR Appendix A to Part 220 - Principles for Determining Costs Applicable to Grants, Contracts, and Other Agreements With...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Principles for Determining Costs Applicable to Grants, Contracts, and Other Agreements With Educational Institutions A Appendix A to Part 220 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET CIRCULARS AND GUIDANCE...

  15. 2 CFR Appendix A to Part 220 - Principles for Determining Costs Applicable to Grants, Contracts, and Other Agreements With...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Principles for Determining Costs Applicable to Grants, Contracts, and Other Agreements With Educational Institutions A Appendix A to Part 220 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET CIRCULARS AND GUIDANCE...

  16. 2 CFR Appendix A to Part 220 - Principles for Determining Costs Applicable to Grants, Contracts, and Other Agreements With...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Principles for Determining Costs Applicable to Grants, Contracts, and Other Agreements With Educational Institutions A Appendix A to Part 220 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET CIRCULARS AND GUIDANCE...

  17. Application of Theories, Principles and Methods of Adult Learning for Managers to Improve Workplace Reactions to Learning, Knowledge and Performance

    ERIC Educational Resources Information Center

    Steier, E. Joseph, III

    2010-01-01

    The objective of this dissertation was to explore the concept that knowledge and application of theories, principles and methods of adult learning to teaching may be a core management competency needed for companies to improve employee reaction to learning, knowledge transfer and behavior as well as engagement, retention and profitability.…

  18. 45 CFR Appendix E to Part 74 - Principles for Determining Costs Applicable to Research and Development Under Grants and...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Research and Development Under Grants and Contracts With Hospitals E Appendix E to Part 74 Public Welfare... Research and Development Under Grants and Contracts With Hospitals i. purpose and scope A. Objectives. This appendix provides principles for determining the costs applicable to research and development...

  19. 45 CFR Appendix E to Part 74 - Principles for Determining Costs Applicable to Research and Development Under Grants and...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Research and Development Under Grants and Contracts With Hospitals E Appendix E to Part 74 Public Welfare... Research and Development Under Grants and Contracts With Hospitals i. purpose and scope A. Objectives. This appendix provides principles for determining the costs applicable to research and development...

  20. 45 CFR Appendix E to Part 74 - Principles for Determining Costs Applicable to Research and Development Under Grants and...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Research and Development Under Grants and Contracts With Hospitals E Appendix E to Part 74 Public Welfare... Research and Development Under Grants and Contracts With Hospitals i. purpose and scope A. Objectives. This appendix provides principles for determining the costs applicable to research and development...

  1. 45 CFR Appendix E to Part 74 - Principles for Determining Costs Applicable to Research and Development Under Grants and...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Research and Development Under Grants and Contracts With Hospitals E Appendix E to Part 74 Public Welfare... Research and Development Under Grants and Contracts With Hospitals i. purpose and scope A. Objectives. This appendix provides principles for determining the costs applicable to research and development...

  2. Designing Excellence in Secondary Vocational Education: Applications of Principles from Effective Schooling and Successful Business Practices. Research Summary Report.

    ERIC Educational Resources Information Center

    Owens, Thomas R.; Crohn, Leslie

    Two sets of research findings are available that may provide a sound base for conducting vocational education research leading to systematic program improvement and to the attainment of excellence in education. The first is effective schooling research and the second concerns principles used by successful businesses in the United States. An…

  3. Phase stability, electronic structure and equation of state of cubic TcN from first-principles calculations

    NASA Astrophysics Data System (ADS)

    Song, T.; Ma, Q.; Sun, X. W.; Liu, Z. J.; Fu, Z. J.; Wei, X. P.; Wang, T.; Tian, J. H.

    2016-09-01

    The phase transition, electronic band structure, and equation of state (EOS) of cubic TcN are investigated by first-principles pseudopotential method based on density-functional theory. The calculated enthalpies show that TcN has a transformation between zincblende and rocksalt phases and the pressure determined by the relative enthalpy is 32 GPa. The calculated band structure indicates the metallic feature and it might make cubic TcN a better candidate for hard materials. Particular attention is paid to the predictions of volume, bulk modulus and its pressure derivative which play a central role in the formulation of approximate EOSs using the quasi-harmonic Debye model.

  4. Principle and Performance of Gas Self-inducing Reactors and Applications to Biotechnology.

    PubMed

    Ye, Qin; Li, Zhimin; Wu, Hui

    2016-01-01

    Gas-liquid contacting is an important unit operation in chemical and biochemical processes, but the gas utilization efficiency is low in conventional gas-liquid contactors especially for sparingly soluble gases. The gas self-inducing impeller is able to recycle gas in the headspace of a reactor to the liquid without utilization of additional equipment such as a gas compressor, and thus, the gas utilization efficiency is significantly enhanced. Gas induction is caused by the low pressure or deep vortex at a sufficiently high impeller speed, and the speed at which gas induction starts is termed the critical speed. The critical impeller speed, gas-induction flow rate, power consumption, and gas-liquid mass transfer are determined by the impeller design and operation conditions. When the reactor is operated in a dead-end mode, all the introduced gas can be completely used, and this feature is especially favorable to flammable and/or toxic gases. In this article, the principles, designs, characteristics of self-inducing reactors, and applications to biotechnology are described.

  5. Rapid methods for the detection of foodborne bacterial pathogens: principles, applications, advantages and limitations

    PubMed Central

    Law, Jodi Woan-Fei; Ab Mutalib, Nurul-Syakima; Chan, Kok-Gan; Lee, Learn-Han

    2015-01-01

    The incidence of foodborne diseases has increased over the years and resulted in major public health problem globally. Foodborne pathogens can be found in various foods and it is important to detect foodborne pathogens to provide safe food supply and to prevent foodborne diseases. The conventional methods used to detect foodborne pathogen are time consuming and laborious. Hence, a variety of methods have been developed for rapid detection of foodborne pathogens as it is required in many food analyses. Rapid detection methods can be categorized into nucleic acid-based, biosensor-based and immunological-based methods. This review emphasizes on the principles and application of recent rapid methods for the detection of foodborne bacterial pathogens. Detection methods included are simple polymerase chain reaction (PCR), multiplex PCR, real-time PCR, nucleic acid sequence-based amplification (NASBA), loop-mediated isothermal amplification (LAMP) and oligonucleotide DNA microarray which classified as nucleic acid-based methods; optical, electrochemical and mass-based biosensors which classified as biosensor-based methods; enzyme-linked immunosorbent assay (ELISA) and lateral flow immunoassay which classified as immunological-based methods. In general, rapid detection methods are generally time-efficient, sensitive, specific and labor-saving. The developments of rapid detection methods are vital in prevention and treatment of foodborne diseases. PMID:25628612

  6. Using Electromagnetic Induction Technique to Detect Hydropedological Dynamics: Principles and Applications

    NASA Astrophysics Data System (ADS)

    Zhu, Qing; Liao, Kaihua; Doolittle, James; Lin, Henry

    2014-05-01

    Hydropedological dynamics including soil moisture variation, subsurface flow, and spatial distributions of different soil properties are important parameters in ecological, environmental, hydrological, and agricultural modeling and applications. However, technical gap exists in mapping these dynamics at intermediate spatial scale (e.g., farm and catchment scales). At intermediate scales, in-situ monitoring provides detailed data, but is restricted in number and spatial coverage; while remote sensing provides more acceptable spatial coverage, but has comparatively low spatial resolution, limited observation depths, and is greatly influenced by the surface condition and climate. As a non-invasive, fast, and convenient geophysical tool, electromagnetic induction (EMI) measures soil apparent electrical conductivity (ECa) and has great potential to bridge this technical gap. In this presentation, principles of different EMI meters are briefly introduced. Then, case studies of using repeated EMI to detect spatial distributions of subsurface convergent flow, soil moisture dynamics, soil types and their transition zones, and different soil properties are presented. The suitability, effectiveness, and accuracy of EMI are evaluated for mapping different hydropedological dynamics. Lastly, contributions of different hydropedological and terrain properties on soil ECa are quantified under different wetness conditions, seasons, and land use types using Classification and Regression Tree model. Trend removal and residual analysis are then used for further mining of EMI survey data. Based on these analyses, proper EMI survey designs and data processing are proposed.

  7. Principles for new optical techniques in medical diagnostics for mHealth applications

    NASA Astrophysics Data System (ADS)

    Balsam, Joshua Michael

    Medical diagnostics is a critical element of effective medical treatment. However, many modern and emerging diagnostic technologies are not affordable or compatible with the needs and conditions found in low-income and middle-income countries and regions. Resource-poor areas require low-cost, robust, easy-to-use, and portable diagnostics devices compatible with telemedicine (i.e. mHealth) that can be adapted to meet diverse medical needs. Many suitable devices will need to be based on optical technologies, which are used for many types of biological analyses. This dissertation describes the fabrication and detection principles for several low-cost optical technologies for mHealth applications including: (1) a webcam based multi-wavelength fluorescence plate reader, (2) a lens-free optical detector used for the detection of Botulinum A neurotoxin activity, (3) a low cost micro-array reader that allows the performance of typical fluorescence based assays demonstrated for the detection of the toxin staphylococcal enterotoxin (SEB), and (4) a wide-field flow cytometer for high throughput detection of fluorescently labeled rare cells. This dissertation discusses how these technologies can be harnessed using readily available consumer electronics components such as webcams, cell phones, CCD cameras, LEDs, and laser diodes. There are challenges in developing devices with sufficient sensitivity and specificity, and approaches are presented to overcoming these challenges to create optical detectors that can serve as low cost medical diagnostics in resource-poor settings for mHealth.

  8. Inverse Problem Optimization Method to Design Passive Samplers for Volatile Organic Compounds: Principle and Application.

    PubMed

    Cao, Jianping; Du, Zhengjian; Mo, Jinhan; Li, Xinxiao; Xu, Qiujian; Zhang, Yinping

    2016-12-20

    Passive sampling is an alternative to active sampling for measuring concentrations of gas-phase volatile organic compounds (VOCs). However, the uncertainty or relative error of the measurements have not been minimized due to the limitations of existing design methods. In this paper, we have developed a novel method, the inverse problem optimization method, to address the problems associated with designing accurate passive samplers. The principle is to determine the most appropriate physical properties of the materials, and the optimal geometry of a passive sampler, by minimizing the relative sampling error based on the mass transfer model of VOCs for a passive sampler. As an example application, we used our proposed method to optimize radial passive samplers for the sampling of benzene and formaldehyde in a normal indoor environment. A new passive sampler, which we have called the Tsinghua Passive Diffusive Sampler (THPDS), for indoor benzene measurement was developed according to the optimized results. Silica zeolite was selected as the sorbent for the THPDS. The measured overall uncertainty of THPDS (22% for benzene) is lower than that of most commercially available passive samplers but is quite a bit larger than the modeled uncertainty (4.8% for benzene, the optimized result), suggesting that further research is required.

  9. Contactless inductive flow tomography: basic principles and first applications in the experimental modelling of continuous casting

    NASA Astrophysics Data System (ADS)

    Stefani, F.; Eckert, S.; Ratajczak, M.; Timmel, K.; Wondrak, T.

    2016-07-01

    Contactless inductive flow tomography (CIFT) aims at reconstructing the flow structure of a liquid metal from the magnetic fields measured at various positions outside the fluid body which are induced by the flow under the influence of one or multiple applied magnetic fields. We recap the basic mathematical principles of CIFT and the results of an experiment in which the propeller-driven three-dimensional flow in a cylindrical had been reconstructed. We also summarize the recent activities to utilize CIFT in various problems connected with the experimental simulation of the continuous casting process. These include flow reconstructions in single-phase and two-phase flow problems in the Mini-LIMMCAST model of slab-casting, studies of the specific effects of an electromagnetic stirrer attached to the Submerged Entry Nozzle (SEN), as well as first successful applications of CIFT on the background of a strong electromagnetic brake field. We conclude by discussing some remaining obstacles for the deployment of CIFT in a real caster.

  10. Rapid methods for the detection of foodborne bacterial pathogens: principles, applications, advantages and limitations.

    PubMed

    Law, Jodi Woan-Fei; Ab Mutalib, Nurul-Syakima; Chan, Kok-Gan; Lee, Learn-Han

    2014-01-01

    The incidence of foodborne diseases has increased over the years and resulted in major public health problem globally. Foodborne pathogens can be found in various foods and it is important to detect foodborne pathogens to provide safe food supply and to prevent foodborne diseases. The conventional methods used to detect foodborne pathogen are time consuming and laborious. Hence, a variety of methods have been developed for rapid detection of foodborne pathogens as it is required in many food analyses. Rapid detection methods can be categorized into nucleic acid-based, biosensor-based and immunological-based methods. This review emphasizes on the principles and application of recent rapid methods for the detection of foodborne bacterial pathogens. Detection methods included are simple polymerase chain reaction (PCR), multiplex PCR, real-time PCR, nucleic acid sequence-based amplification (NASBA), loop-mediated isothermal amplification (LAMP) and oligonucleotide DNA microarray which classified as nucleic acid-based methods; optical, electrochemical and mass-based biosensors which classified as biosensor-based methods; enzyme-linked immunosorbent assay (ELISA) and lateral flow immunoassay which classified as immunological-based methods. In general, rapid detection methods are generally time-efficient, sensitive, specific and labor-saving. The developments of rapid detection methods are vital in prevention and treatment of foodborne diseases.

  11. Superhydrophobic hierarchically structured surfaces in biology: evolution, structural principles and biomimetic applications.

    PubMed

    Barthlott, W; Mail, M; Neinhuis, C

    2016-08-06

    A comprehensive survey of the construction principles and occurrences of superhydrophobic surfaces in plants, animals and other organisms is provided and is based on our own scanning electron microscopic examinations of almost 20 000 different species and the existing literature. Properties such as self-cleaning (lotus effect), fluid drag reduction (Salvinia effect) and the introduction of new functions (air layers as sensory systems) are described and biomimetic applications are discussed: self-cleaning is established, drag reduction becomes increasingly important, and novel air-retaining grid technology is introduced. Surprisingly, no evidence for lasting superhydrophobicity in non-biological surfaces exists (except technical materials). Phylogenetic trees indicate that superhydrophobicity evolved as a consequence of the conquest of land about 450 million years ago and may be a key innovation in the evolution of terrestrial life. The approximate 10 million extant species exhibit a stunning diversity of materials and structures, many of which are formed by self-assembly, and are solely based on a limited number of molecules. A short historical survey shows that bionics (today often called biomimetics) dates back more than 100 years. Statistical data illustrate that the interest in biomimetic surfaces is much younger still. Superhydrophobicity caught the attention of scientists only after the extreme superhydrophobicity of lotus leaves was published in 1997. Regrettably, parabionic products play an increasing role in marketing.This article is part of the themed issue 'Bioinspired hierarchically structured surfaces for green science'.

  12. Second Order Boltzmann-Gibbs Principle for Polynomial Functions and Applications

    NASA Astrophysics Data System (ADS)

    Gonçalves, Patrícia; Jara, Milton; Simon, Marielle

    2017-01-01

    In this paper we give a new proof of the second order Boltzmann-Gibbs principle introduced in Gonçalves and Jara (Arch Ration Mech Anal 212(2):597-644, 2014). The proof does not impose the knowledge on the spectral gap inequality for the underlying model and it relies on a proper decomposition of the antisymmetric part of the current of the system in terms of polynomial functions. In addition, we fully derive the convergence of the equilibrium fluctuations towards (1) a trivial process in case of super-diffusive systems, (2) an Ornstein-Uhlenbeck process or the unique energy solution of the stochastic Burgers equation, as defined in Gubinelli and Jara (SPDEs Anal Comput (1):325-350, 2013) and Gubinelli and Perkowski (Arxiv:1508.07764, 2015), in case of weakly asymmetric diffusive systems. Examples and applications are presented for weakly and partial asymmetric exclusion processes, weakly asymmetric speed change exclusion processes and hamiltonian systems with exponential interactions.

  13. Bioremediation techniques-classification based on site of application: principles, advantages, limitations and prospects.

    PubMed

    Azubuike, Christopher Chibueze; Chikere, Chioma Blaise; Okpokwasili, Gideon Chijioke

    2016-11-01

    Environmental pollution has been on the rise in the past few decades owing to increased human activities on energy reservoirs, unsafe agricultural practices and rapid industrialization. Amongst the pollutants that are of environmental and public health concerns due to their toxicities are: heavy metals, nuclear wastes, pesticides, green house gases, and hydrocarbons. Remediation of polluted sites using microbial process (bioremediation) has proven effective and reliable due to its eco-friendly features. Bioremediation can either be carried out ex situ or in situ, depending on several factors, which include but not limited to cost, site characteristics, type and concentration of pollutants. Generally, ex situ techniques apparently are more expensive compared to in situ techniques as a result of additional cost attributable to excavation. However, cost of on-site installation of equipment, and inability to effectively visualize and control the subsurface of polluted sites are of major concerns when carrying out in situ bioremediation. Therefore, choosing appropriate bioremediation technique, which will effectively reduce pollutant concentrations to an innocuous state, is crucial for a successful bioremediation project. Furthermore, the two major approaches to enhance bioremediation are biostimulation and bioaugmentation provided that environmental factors, which determine the success of bioremediation, are maintained at optimal range. This review provides more insight into the two major bioremediation techniques, their principles, advantages, limitations and prospects.

  14. Oxidation and magnetic states of chalcopyrite CuFeS2: A first principles calculation

    NASA Astrophysics Data System (ADS)

    Klekovkina, V. V.; Gainov, R. R.; Vagizov, F. G.; Dooglav, A. V.; Golovanevskiy, V. A.; Pen'kov, I. N.

    2014-06-01

    The ground state band structure, magnetic moments, charges and population numbers of electronic shells of Cu and Fe atoms have been calculated for chalcopyrite CuFeS2 using density functional theory. The comparison between our calculation results and experimental data (X-ray photoemission, X-ray absorption and neutron diffraction spectroscopy) has been made. Our calculations predict a formal oxidation state for chalcopyrite as Cu1+Fe3+S{2/2-}. However, the assignment of formal valence state to transition metal atoms appears to be oversimplified. It is anticipated that the valence state can be confirmed experimentally by nuclear magnetic and nuclear quadrupole resonance and Mössbauer spectroscopy methods.

  15. Variation Principles and Applications in the Study of Cell Structure and Aging

    NASA Technical Reports Server (NTRS)

    Economos, Angelos C.; Miquel, Jaime; Ballard, Ralph C.; Johnson, John E., Jr.

    1981-01-01

    In this report we have attempted to show that "some reality lies concealed in biological variation". This "reality" has its principles, laws, mechanisms, and rules, only a few of which we have sketched. A related idea we pursued was that important information may be lost in the process of ignoring frequency distributions of physiological variables (as is customary in experimental physiology and gerontology). We suggested that it may be advantageous to expand one's "statistical field of vision" beyond simple averages +/- standard deviations. Indeed, frequency distribution analysis may make visible some hidden information not evident from a simple qualitative analysis, particularly when the effect of some external factor or condition (e.g., aging, dietary chemicals) is being investigated. This was clearly illustrated by the application of distribution analysis in the study of variation in mouse liver cellular and fine structure, and may be true of fine structural studies in general. In living systems, structure and function interact in a dynamic way; they are "inseparable," unlike in technological systems or machines. Changes in fine structure therefore reflect changes in function. If such changes do not exceed a certain physiologic range, a quantitative analysis of structure will provide valuable information on quantitative changes in function that may not be possible or easy to measure directly. Because there is a large inherent variation in fine structure of cells in a given organ of an individual and among individuals, changes in fine structure can be analyzed only by studying frequency distribution curves of various structural characteristics (dimensions). Simple averages +/- S.D. do not in general reveal all information on the effect of a certain factor, because often this effect is not uniform; on the contrary, this will be apparent from distribution analysis because the form of the curves will be affected. We have also attempted to show in this chapter that

  16. Localization of the Energy States of Lead Inducing the Effect of Rectification and Negative Differential Resistance Predicted by First-Principles Study

    NASA Astrophysics Data System (ADS)

    Min, Y.; Fang, J. H.; Zhong, C. G.; Dong, Z. C.; Chen, C. P.; Yao, K. L.

    2013-07-01

    The first-principles calculations of the transport characteristics of 4-(5-(2-(5-(4-mercaptophenyl)thiophene-2-yl)ethyl)pyridin-2-yl)benzenethiol sandwiched between two gold leads are performed. The effect of rectification and negative differential resistance (NDR) are obtained, which promise the potential applications in the field of molecular electronics. The rectification effect is 4.49. The peak/valley ratio of the NDR effect is as large as 4.51 for the forward bias and 12.09 for the reverse bias. The strong coupling between gold lead and molecule through thiolate results in the localization of the energy states of gold lead, which may induce the effect of rectification and NDR.

  17. The Equal Marginal Value Principle: A Graphical Analysis with Environmental Applications.

    ERIC Educational Resources Information Center

    Yates, Andrew J.

    1998-01-01

    Maintains that the equal marginal value principle may not be optimal in the analysis of the cost-effectiveness of policies to reduce auto emissions, the economics of garbage disposal, and the economics of pollution abatement. Argues that examining these exceptions can help students understand the equal marginal value principle. (MJP)

  18. Precautionary Principles: General Definitions and Specific Applications to Genetically Modified Organisms

    ERIC Educational Resources Information Center

    Lofstedt, Ragnar E.; Fischhoff, Baruch; Fischhoff, Ilya R.

    2002-01-01

    Precautionary principles have been proposed as a fundamental element of sound risk management. Their advocates see them as guiding action in the face of uncertainty, encouraging the adoption of measures that reduce serious risks to health, safety, and the environment. Their opponents may reject the very idea of precautionary principles, find…

  19. Erickson for Counselors and Educators: A Review and Practical Application of Six Treatment Principles.

    ERIC Educational Resources Information Center

    Sahlin, Francine C.

    1987-01-01

    Six treatment principles of Milton Erickson, physician and hypnotherapist, are applied to counselors and educators. Principles include: (1) People are always responding, always communicating. (2) Respect all messages from the client. (3) People make the best choice for themselves at any given moment. (4) Teach choice; never attempt to take choice…

  20. Application of Merrill's First Principles of Instruction in a Museum Education Context

    ERIC Educational Resources Information Center

    Nelson, Kari Ross

    2015-01-01

    In an effort to support a solid grounding in educational theory within the field of museum education, three texts considered essential reading for museum educators were surveyed for correlations with Merrill's First Principles of Instruction, an influential work in the field of instructional design. Each of five First Principles were found to be…

  1. An Application of Total Quality Principles in Transforming the Culture of Classrooms

    ERIC Educational Resources Information Center

    Algozzine, Bob; Audette, Robert H.; Marr, Mary Beth; Algozzine, Kate

    2005-01-01

    During the 1990s, many public schools began to apply the principles of Total Quality Management. As they moved ahead, they discovered that most of the separate principles that comprise Total Quality Management are not new to public education. Theories and practices using similar and related ideas have been championed by educators for generations.…

  2. 12 CFR 621.3 - Application of generally accepted accounting principles.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... principles. 621.3 Section 621.3 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM ACCOUNTING... reports to the Farm Credit Administration, in accordance with generally accepted accounting principles... management and the Farm Credit Administration, in accordance with generally accepted accounting...

  3. 20 CFR 625.11 - Provisions of State law applicable.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 3 2013-04-01 2013-04-01 false Provisions of State law applicable. 625.11 Section 625.11 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR DISASTER UNEMPLOYMENT ASSISTANCE § 625.11 Provisions of State law applicable. The terms and conditions of the State...

  4. 20 CFR 625.11 - Provisions of State law applicable.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 3 2012-04-01 2012-04-01 false Provisions of State law applicable. 625.11 Section 625.11 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR DISASTER UNEMPLOYMENT ASSISTANCE § 625.11 Provisions of State law applicable. The terms and conditions of the State...

  5. 20 CFR 625.11 - Provisions of State law applicable.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Provisions of State law applicable. 625.11 Section 625.11 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR DISASTER UNEMPLOYMENT ASSISTANCE § 625.11 Provisions of State law applicable. The terms and conditions of the State...

  6. 20 CFR 625.11 - Provisions of State law applicable.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Provisions of State law applicable. 625.11 Section 625.11 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR DISASTER UNEMPLOYMENT ASSISTANCE § 625.11 Provisions of State law applicable. The terms and conditions of the State...

  7. 20 CFR 625.11 - Provisions of State law applicable.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 3 2014-04-01 2014-04-01 false Provisions of State law applicable. 625.11 Section 625.11 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR DISASTER UNEMPLOYMENT ASSISTANCE § 625.11 Provisions of State law applicable. The terms and conditions of the State...

  8. 75 FR 30773 - United States Patent Applicant Survey

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-02

    ... Patent and Trademark Office United States Patent Applicant Survey ACTION: Proposed collection; comment request. SUMMARY: The United States Patent and Trademark Office (USPTO), as part of its continuing effort... United States Patent Applicant Survey as part of the continuing effort to better predict the...

  9. 17 CFR 30.11 - Applicability of state law.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 1 2014-04-01 2014-04-01 false Applicability of state law. 30... FUTURES AND FOREIGN OPTIONS TRANSACTIONS § 30.11 Applicability of state law. Pursuant to section 12(e)(2) of the Act, the provisions of any state law, including any rule or regulation thereunder, may...

  10. 20 CFR 617.16 - Applicable State law.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 3 2012-04-01 2012-04-01 false Applicable State law. 617.16 Section 617.16... law. (a) What law governs. The applicable State law for any individual, for all of the purposes of this part 617, is the State law of the State— (1) In which the individual is entitled to UI (whether...

  11. 17 CFR 30.11 - Applicability of state law.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 1 2011-04-01 2011-04-01 false Applicability of state law. 30... FUTURES AND FOREIGN OPTIONS TRANSACTIONS § 30.11 Applicability of state law. Pursuant to section 12(e)(2) of the Act, the provisions of any state law, including any rule or regulation thereunder, may...

  12. 20 CFR 617.16 - Applicable State law.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Applicable State law. 617.16 Section 617.16... law. (a) What law governs. The applicable State law for any individual, for all of the purposes of this part 617, is the State law of the State— (1) In which the individual is entitled to UI (whether...

  13. 17 CFR 30.11 - Applicability of state law.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 1 2012-04-01 2012-04-01 false Applicability of state law. 30... FUTURES AND FOREIGN OPTIONS TRANSACTIONS § 30.11 Applicability of state law. Pursuant to section 12(e)(2) of the Act, the provisions of any state law, including any rule or regulation thereunder, may...

  14. Rotordynamic analysis using the Complex Transfer Matrix: An application to elastomer supports using the viscoelastic correspondence principle

    NASA Astrophysics Data System (ADS)

    Varney, Philip; Green, Itzhak

    2014-11-01

    Numerous methods are available to calculate rotordynamic whirl frequencies, including analytic methods, finite element analysis, and the transfer matrix method. The typical real-valued transfer matrix (RTM) suffers from several deficiencies, including lengthy computation times and the inability to distinguish forward and backward whirl. Though application of complex coordinates in rotordynamic analysis is not novel per se, specific advantages gained from using such coordinates in a transfer matrix analysis have yet to be elucidated. The present work employs a complex coordinate redefinition of the transfer matrix to obtain reduced forms of the elemental transfer matrices in inertial and rotating reference frames, including external stiffness and damping. Application of the complex-valued state variable redefinition results in a reduction of the 8×8 RTM to the 4×4 Complex Transfer Matrix (CTM). The CTM is advantageous in that it intrinsically separates forward and backward whirl, eases symbolic manipulation by halving the transfer matrices’ dimension, and provides significant improvement in computation time. A symbolic analysis is performed on a simple overhung rotor to demonstrate the mathematical motivation for whirl frequency separation. The CTM's utility is further shown by analyzing a rotordynamic system supported by viscoelastic elastomer rings. Viscoelastic elastomer ring supports can provide significant damping while reducing the cost and complexity associated with conventional components such as squeeze film dampers. The stiffness and damping of a viscoelastic damper ring are determined herein as a function of whirl frequency using the viscoelastic correspondence principle and a constitutive fractional calculus viscoelasticity model. The CTM is then employed to obtain the characteristic equation, where the whirl frequency dependent stiffness and damping of the elastomer supports are included. The Campbell diagram is shown, demonstrating the CTM

  15. First-principles investigations of equation of states and phase transitions in PaN under pressure

    NASA Astrophysics Data System (ADS)

    Modak, P.; Verma, Ashok K.

    2013-02-01

    We have studied equation of states (EOS) and pressure induced structural transitions of PaN using first principles electronic structure and total energy calculations. We have predicted that PaN undergoes a structural transition from NaCl to R-3m structure at around 55 GPa pressure. We have also calculated the enthalpy as a function of rhombohedral angle at constant pressures for the Buerger pathway of B1-B2 transition where R-3m is the intermediate state. We have showed that NaCl structure becomes mechanically unstable and f electrons of Pa plays crucial role to stabilize R-3m structure instead of CsCl at high pressure.

  16. Application of the Principle of Linked Functions to ATP-Driven Ion Pumps: Kinetics of Activation by ATP

    NASA Astrophysics Data System (ADS)

    Reynolds, Jacqueline A.; Johnson, Edward A.; Tanford, Charles

    1985-06-01

    If a ligand binds with unequal affinity to two distinct states of a protein, then the equilibrium between the two states becomes a function of the concentration of the ligand. A necessary consequence is that the ligand must also affect the forward and/or reverse rate constants for transition between the two states. For an enzyme or transport protein with such a transition as a slow step in the catalytic cycle, the overall rate also becomes a function of ligand concentration. These conclusions are independent of whether or not the ligand is a direct participant in the reaction. If it is a direct partitipant, then the kinetic effect arising from the principle of linked functions is distinct from the direct catalytic effect. These principles suffice to account for the biphasic response of the hydrolytic activity of ATP-driven ion pumps to the concentration of ATP, without the need to invoke more than one ATP binding site per catalytic center.

  17. A First-Principles Multi-phase Equation of State of Carbon under Extreme Conditions

    SciTech Connect

    Correa, A A; Benedict, X L; Young, D A; Schwegler, E; Bonev, S A

    2008-02-01

    We describe the construction of a multi-phase equation of state for carbon at extreme pressures based on ab initio electronic structure calculations of two solid phases (diamond and BC8) and the liquid. Solid-phase free energies are built from knowledge of the cold curves and phonon calculations, together with direct ab initio molecular dynamics calculations of the equation of state, which are used to extract anharmonic corrections to the phonon free energy. The liquid free energy is constructed based on results from molecular dynamics calculations and constraints determined from previously calculated melting curves, assuming a simple solid-like free energy model. The resulting equation of state is extended to extreme densities and temperatures with a Thomas Fermi-based free energy model. Comparisons to available experimental results are discussed.

  18. Determining charge state of graphene vacancy by noncontact atomic force microscopy and first-principles calculations.

    PubMed

    Liu, Y; Weinert, M; Li, L

    2015-01-21

    Graphene vacancies are engineered for novel functionalities, however, the charge state of these defects, the key parameter that is vital to charge transfer during chemical reactions and carrier scattering, is generally unknown. Here, we carried out atomic resolution imaging of graphene vacancy defects created by Ar plasma using noncontact atomic force microscopy, and made the first determination of their charge state by local contact potential difference measurements. Combined with density functional theory calculations, we show that graphene vacancies are typically positively charged, with size-dependent charge states that are not necessarily integer-valued. These findings provide new insights into carrier scattering by vacancy defects in graphene, as well as its functionalization for chemical sensing and catalysis, and underline the tunability of these functions by controlling the size of vacancy defect.

  19. Le Chatelier Principle for Out-of-Equilibrium and Boundary-Driven Systems: Application to Dynamical Phase Transitions

    NASA Astrophysics Data System (ADS)

    Shpielberg, O.; Akkermans, E.

    2016-06-01

    A stability analysis is presented for boundary-driven and out-of-equilibrium systems in the framework of the hydrodynamic macroscopic fluctuation theory. A Hamiltonian description is proposed which allows us to thermodynamically interpret the additivity principle. A necessary and sufficient condition for the validity of the additivity principle is obtained as an extension of the Le Chatelier principle. These stability conditions result from a diagonal quadratic form obtained using the cumulant generating function. This approach allows us to provide a proof for the stability of the weakly asymmetric exclusion process and to reduce the search for stability to the solution of two coupled linear ordinary differential equations instead of nonlinear partial differential equations. Additional potential applications of these results are discussed in the realm of classical and quantum systems.

  20. Toward a More Effective Economic Principles Class: The Florida State University Experience.

    ERIC Educational Resources Information Center

    Tuckman, Barbara; Tuckman, Howard

    1975-01-01

    This special issue explores alternative approaches to teaching the college introductory economics course. Using insights gained from learning theory, suggestions from the Joint Council on Economic Education, and trial and error, several faculty members at the Florida State University experimented with various techniques and approaches designed to…

  1. Learning to Pull the Thread: Application of Guided Discovery Principles to the Inquiry Process

    SciTech Connect

    Greitzer, Frank L.; Rice, Douglas M.; Eaton, Sharon L.; Perkins, Michael C.

    2005-11-28

    Investigation of direct causes is a fundamental component of inquiry and analysis tasks that require skilled observations, logical thinking, and a persistent search for a complete understanding of the events. The need to cultivate such skills and persistence is a major challenge for diverse disciplines from accident investigation to forensics to intelligence analysis. In this context, persistence means to keep pulling the threads of evidence until a sufficient understanding of cause-effect relationships has emerged. The training challenge is rooted in fundamental questions about performance measurement and instruction: Can we effectively instill the required skills and persistence by merely informing learners through traditional classroom instruction? Or would such cognitive skills and persistence be better developed and refined through carefully crafted experience-based training? In instructional systems design terminology, this question may be phrased as a choice between receptive/directive instructional architectures that focus on ASK and TELL approaches versus approaches that emphasize SHOW and DO. The latter, more interactive instructional approaches emphasize active learning and performance assessment. We suggest that active, performance-based paradigms such as scenario-based and guided-discovery learning approaches may provide more effective solutions. By immersing the learner in appropriate interactive scenarios, we can ascertain through actual performance the extent to which the learner demonstrates the objective knowledge or skills. We have previously reported on an application of guided-discovery principles to develop Web-based awareness training for security inquiry officials. The purpose of this paper is to report on subsequent research that employs guided-discovery scenarios to enhance the learner's evidential reasoning process through practice in following threads to identify direct causes. Implications for inquiry/analysis and cognitive skills

  2. Design principle and calculations of a Scheffler fixed focus concentrator for medium temperature applications

    SciTech Connect

    Munir, A.; Hensel, O.; Scheffler, W.

    2010-08-15

    Scheffler fixed focus concentrators are successfully used for medium temperature applications in different parts of the world. These concentrators are taken as lateral sections of paraboloids and provide fixed focus away from the path of incident beam radiations throughout the year. The paper presents a complete description about the design principle and construction details of an 8 m{sup 2} surface area Scheffler concentrator. The first part of the paper presents the mathematical calculations to design the reflector parabola curve and reflector elliptical frame with respect to equinox (solar declination = 0) by selecting a specific lateral part of a paraboloid. Crossbar equations and their ellipses, arc lengths and their radii are also calculated to form the required lateral section of the paraboloid. Thereafter, the seasonal parabola equations are calculated for two extreme positions of summer and winter in the northern hemisphere (standing reflectors). The slopes of the parabola equations for equinox (solar declination = 0), summer (solar declination = +23.5) and winter (solar declination = -23.5) for the Scheffler reflector (8 m{sup 2} surface area) are calculated to be 0.17, 0.28, and 0.13 respectively. The y-intercepts of the parabola equations for equinox, summer and winter are calculated as 0, 0.54, and -0.53 respectively. By comparing with the equinox parabola curve, the summer parabola is found to be smaller in size and uses the top part of the parabola curve while the winter parabola is bigger in size and uses the lower part of the parabola curve to give the fixed focus. For this purpose, the reflector assembly is composed of flexible crossbars and a frame to induce the required change of the parabola curves with the changing solar declination. The paper also presents the calculation procedure of seasonal parabola equations for standing reflectors in the southern hemisphere as well as for laying reflectors in the northern and southern hemispheres. Highly

  3. Ecosystem management: Principles and applications. Volume 2. Forest Service general technical report

    SciTech Connect

    Jensen, M.E.; Bourgeron, P.S.

    1994-02-01

    The document provides land managers with practical suggestions for implementing ecosystem management. It contains 28 papers organized into five sections; historical perspectives, ecological principles, sampling design, case studies, and implementation strategies.

  4. A new approach to problem of enzymatic catalysis based on excited state of proteins and Le Chatelier's principle.

    PubMed

    Dmitriev, Leonid F

    2007-08-01

    A hypothesis is proposed that the energy of an exothermic reaction in an aqueous medium can be used to shift the equilibrium in an endothermic reaction involving hydrated ions. This takes place according to Le Chatelier's principle, and the water dissociation in the homogeneous medium at the protein-water interface gives rise to concentration gradients of ions H(+) and OH(-). The hypothesis implies that the chemical conversion of the substrate into the product is preceded by an attack of hydrated ions on the protein and their association on the protein (an attack of the nucleophilic agent with the subsequent proton addition). This leads to the formation of a cyclic peroxide in an amino acid residue and to the transition C=O-->[C=O](*). The return of carbonyl to the ground state ultimately allows to accumulate a part of the free energy and to use it to bring the enzyme to a state where the conformational energy is higher. Thus, an electronically excited state of a protein is regarded as a state required for dark reactions. This means that, along with the substrate sorption on the protein, the other aspect of the behavior of the dynamic system should be taken into account.

  5. Application of Lean Manufacturing Principles to DARHT-II Induction Cell Refurbishment

    DTIC Science & Technology

    2005-06-01

    has been transformed to support Lean Manufacturing . This paper presents and discusses the processes and facility configuration developed to apply Lean Manufacturing for cell refurbishment....commissioning milestones of the DARHT second-axis accelerator. To this end, Los Alamos National Laboratory (LANL) has adopted the principles of Lean ... Manufacturing and applied them to the cell refurbishment effort. These principles emphasize streamline thinking and methodologies for manufacturing

  6. The divine clockwork: Bohr's correspondence principle and Nelson's stochastic mechanics for the atomic elliptic state

    SciTech Connect

    Durran, Richard; Neate, Andrew; Truman, Aubrey

    2008-03-15

    We consider the Bohr correspondence limit of the Schroedinger wave function for an atomic elliptic state. We analyze this limit in the context of Nelson's stochastic mechanics, exposing an underlying deterministic dynamical system in which trajectories converge to Keplerian motion on an ellipse. This solves the long standing problem of obtaining Kepler's laws of planetary motion in a quantum mechanical setting. In this quantum mechanical setting, local mild instabilities occur in the Keplerian orbit for eccentricities greater than (1/{radical}(2)) which do not occur classically.

  7. First-Principles Momentum Dependent Local Ansatz Approach to the Ground-State Properties of Iron-Group Transition Metals

    NASA Astrophysics Data System (ADS)

    Kakehashi, Yoshiro; Chandra, Sumal

    2016-08-01

    The ground-state properties of iron-group transition metals from Sc to Cu have been investigated on the basis of the first-principles momentum dependent local ansatz (MLA) theory. Correlation energy gain is found to show large values for Mn and Fe: 0.090 Ry (Mn) and 0.094 Ry (Fe). The Hund-rule coupling energies are found to be 3000 K (Fe), 1400 K (Co), and 300 K (Ni). It is suggested that these values can resolve the inconsistency in magnetic energy between the density functional theory and the first-principles dynamical coherent potential approximation theory at finite temperatures. Charge fluctuations are shown to be suppressed by the intra-orbital correlations and inter-orbital charge-charge correlations, so that they show nearly constant values from V to Fe: 1.57 (V and Cr), 1.52 (Mn), and 1.44 (Fe), which are roughly twice as large as those obtained by the d band model. The amplitudes of local moments are enhanced by the intra-orbital and inter-orbital spin-spin correlations and show large values for Mn and Fe: 2.87 (Mn) and 2.58 (Fe). These values are in good agreement with the experimental values estimated from the effective Bohr magneton number and the inner core photoemission data.

  8. The occurrence of ground water in the United States, with a discussion of principles

    USGS Publications Warehouse

    Meinzer, Oscar Edward

    1923-01-01

    The writer has planned and partly prepared a series of six papers on ground water in the United States. These papers are to deal with (1) occurrence, (2) origin, discharge, and quantity, (3) movement and head, (4) quality, (5) recovery and use, and (6) ground-water provinces. The present paper is the first of the series.The writer is indebted to many colaborers for assistance in preparing this paper, especially to the following members of the United States Geological Survey: M. R. Campbell, who read the entire paper; E. W. Shaw, C. E. Van Orstrand, A. F. Melcher, and C. K. Wentworth, who examined Chapter I; W. C. Alden, who examined Chapters II and IV with special reference to their statements regarding glacial geology; E. S. Larsen, who examined a part of Chapter II; G. W. Stosfi, who examined Chapter III; T. W. Stanton, who examined Chapter IV; L. W. Stephenson, who examined the parts of Chapter IV that relate to the Coastal Plain; C. W. Cooke, who furnished many unpublished data on the geology of the Coastal Plain; Miss M. G. Wilmarth, who gave valuable help in compiling the geologic sections; D. G. Thompson and Miss Norah E. Dowell, who furnished original data on the mechanical composition and porosity of various sedimentary materials; B. H. Lane, who made valuable criticisms of the text; and Martin Solem, who had charge of the preparation of the illustrations.

  9. Solar hot water systems for the southeastern United States: principles and construction of breadbox water heaters

    SciTech Connect

    1983-02-01

    The use of solar energy to provide hot water is among the easier solar technologies for homeowners to utilize. In the Southeastern United States, because of the mild climate and abundant sunshine, solar energy can be harnessed to provide a household's hot water needs during the non-freezing weather period mid-April and mid-October. This workbook contains detailed plans for building breadbox solar water heaters that can provide up to 65% of your hot water needs during warm weather. If fuel costs continue to rise, the annual savings obtained from a solar water heater will grow dramatically. The designs in this workbook use readily available materials and the construction costs are low. Although these designs may not be as efficient as some commercially available systems, most of a household's hot water needs can be met with them. The description of the breadbox water heater and other types of solar systems will help you make an informed decision between constructing a solar water heater or purchasing one. This workbook is intended for use in the southeastern United States and the designs may not be suitable for use in colder climates.

  10. Inverse simulation as a tool for flight dynamics research—Principles and applications

    NASA Astrophysics Data System (ADS)

    Thomson, Douglas; Bradley, Roy

    2006-05-01

    The technique of inverse simulation is finding application in many and varied fields. As the name implies this technique is used to calculate the control action required to achieve a specified system response. The field of aircraft flight dynamics is particularly suited to this form of simulation as the question of what control actions must the pilot (or automatic flight control system) take for the aircraft to fly along a particular trajectory (a landing approach, for example) is often asked. This paper looks specifically at the application of inverse simulation in flight dynamics. The aim is not only to give an overview of the various techniques and applications but also to provide guidance to potential users of the technique on several of the physical and numerical features often observed in the results. An extensive review of the methodologies used within the family of inverse simulations is presented followed by a formal treatment of the theoretical development of inverse simulation as an established technique. A case study involving the inverse simulation of a helicopter flying a slalom manoeuvre is presented to demonstrate the application of inverse simulation in a flight dynamics analysis. An important feature of the use of inverse simulation is that it is necessary to define the output response required-in the case of flight dynamics the required flight path has to be modelled. Some of the methods used are documented, and their validity discussed. The paper also gives an insight into the types of problem which can be addressed by inverse simulation by detailing some of the many applications to which it has been put in the past. These include studies of rotorcraft handling qualities, performance and design, and pilot modelling as well as model validation. An important element of this paper is the formal, theoretical analysis of some of the numerical and physical features exhibited by inverse simulation which should aid potential users to interpret their

  11. Possibility of transforming the electronic structure of one species of graphene adatoms into that of another by application of gate voltage: First-principles calculations

    NASA Astrophysics Data System (ADS)

    Chan, Kevin T.; Lee, Hoonkyung; Cohen, Marvin L.

    2011-10-01

    Graphene provides many advantages for controlling the electronic structure of adatoms and other adsorbates via gating. Using the projected density of states and charge density obtained from first-principles density-functional periodic supercell calculations, we investigate the possibility of performing “alchemy” of adatoms on graphene, i.e., transforming the electronic structure of one species of adatom into that of another species by application of a gate voltage. Gating is modeled as a change in the number of electrons in the unit cell, with the inclusion of a compensating uniform background charge. Within this model and the generalized gradient approximation to the exchange-correlation functional, we find that such transformations are possible for K, Ca, and several transition-metal adatoms. Gate control of the occupation of the p states of In on graphene is also investigated. The validity of the supercell approximation with uniform compensating charge and the model for exchange and correlation is also discussed.

  12. On the Applicability of the Green Chemistry Principles to Sustainability of Organic Matter on Asteroids

    NASA Astrophysics Data System (ADS)

    Kolb, Vera M.

    2010-06-01

    The connection between astrobiology and green chemistry represents a new approach to sustainability of organic matter on asteroids or similar bodies. Green chemistry is chemistry which is environmentally friendly. One obvious way for chemistry to be green is to use water as a solvent, instead of more toxic organic solvents. Many astrobiological reactions occur in the aqueous medium, for example in the prebiotic soup or during the aqueous alteration period on asteroids. Thus any advances in the green organic reactions in water are directly applicable to astrobiology. Another green chemistry approach is to abolish use of toxic solvents. This can be accomplished by carrying out the reactions without a solvent in the solventless or solid-state reactions. The advances in these green reactions are directly applicable to the chemistry on asteroids during the periods when water was not available. Many reactions on asteroids may have been done in the solid mixtures. These reactions may be responsible for a myriad of organic compounds that have been isolated from the meteorites.

  13. Monte Carlo Simulations in Statistical Physics -- From Basic Principles to Advanced Applications

    NASA Astrophysics Data System (ADS)

    Janke, Wolfhard

    2013-08-01

    This chapter starts with an overview of Monte Carlo computer simulation methodologies which are illustrated for the simple case of the Ising model. After reviewing importance sampling schemes based on Markov chains and standard local update rules (Metropolis, Glauber, heat-bath), nonlocal cluster-update algorithms are explained which drastically reduce the problem of critical slowing down at second-order phase transitions and thus improve the performance of simulations. How this can be quantified is explained in the section on statistical error analyses of simulation data including the effect of temporal correlations and autocorrelation times. Histogram reweighting methods are explained in the next section. Eventually, more advanced generalized ensemble methods (simulated and parallel tempering, multicanonical ensemble, Wang-Landau method) are discussed which are particularly important for simulations of first-order phase transitions and, in general, of systems with rare-event states. The setup of scaling and finite-size scaling analyses is the content of the following section. The chapter concludes with two advanced applications to complex physical systems. The first example deals with a quenched, diluted ferromagnet, and in the second application we consider the adsorption properties of macromolecules such as polymers and proteins to solid substrates. Such systems often require especially tailored algorithms for their efficient and successful simulation.

  14. Event-based state estimation for a class of complex networks with time-varying delays: A comparison principle approach

    NASA Astrophysics Data System (ADS)

    Zhang, Wenbing; Wang, Zidong; Liu, Yurong; Ding, Derui; Alsaadi, Fuad E.

    2017-01-01

    The paper is concerned with the state estimation problem for a class of time-delayed complex networks with event-triggering communication protocol. A novel event generator function, which is dependent not only on the measurement output but also on a predefined positive constant, is proposed with hope to reduce the communication burden. A new concept of exponentially ultimate boundedness is provided to quantify the estimation performance. By means of the comparison principle, some sufficient conditions are obtained to guarantee that the estimation error is exponentially ultimately bounded, and then the estimator gains are obtained in terms of the solution of certain matrix inequalities. Furthermore, a rigorous proof is proposed to show that the designed triggering condition is free of the Zeno behavior. Finally, a numerical example is given to illustrate the effectiveness of the proposed event-based estimator.

  15. First-principle Calculations of Equation of State for Metals at High Energy Density

    NASA Astrophysics Data System (ADS)

    Minakov, Dmitry; Levashov, Pavel; Khishchenko, Konstantin

    2012-02-01

    In this work, we present quantum molecular dynamics calculations of the shock Hugoniots of solid and porous samples as well as release isentropes and isentropic sound velocity behind the shock front for aluminum. Also we perform similar calculations for nickel and iron. We use the VASP code with ultrasoft and PAW pseudopotentials and GGA exchange-correlation functional. Up to 512 particles have been used in calculations. To calculate Hugoniots we solve the Hugoniot equation numerically. To obtain release isentropes, we use Zel'dovich's approach and integrate an ordinary differential equation for the temperature thus restoring all thermodynamic parameters. Isentropic sound velocity is calculated by differentiation of pressure along isentropes. The results of our calculations are in good agreement with experimental data at densities both higher and lower than the normal one. Thus, quantum molecular dynamics results can be effectively used for verification or calibration of semiempirical equations of state under conditions of lack of experimental information at high energy densities.

  16. Jupiter and Saturn Interior Models with an Equation of State Derived From First Principles Computer Simulations

    NASA Astrophysics Data System (ADS)

    Hubbard, William B.; Militzer, B.; Vorberger, J.

    2006-09-01

    We report results from recent investigations of the interior structures of Jupiter and Saturn using state-of-the-art computer simulations of dense fluid hydrogen and helium. Thermodynamic properties used in the models were obtained using density-functional molecular dynamics (DFT-MD) simulations on a grid of temperature and density points spanning the interiors of these planets. In addition to calculations for pure hydrogen, simulation results for the different concentrations of hydrogen-helium mixtures are presented. The corrections to the commonly used linear mixing approximation are characterized, and it is demonstrated how the addition of helium increases the stability of the molecular phase of hydrogen. Our interior models update the suite of models that were based on the widely used Saumon-Chabrier-Van Horn (SCVH) equation of state for hydrogen and helium. Unlike SCVH, the computed DFT-EOS does not predict any first-order thermodynamic discontinuities associated with pressure-dissociation and metallization of hydrogen. Instead, the DFT-EOS predicts that the molecular dissociation leads intermediate decrease in pressure, which has profound effects on the thermodynamic properties in a zone approximately 6000 km below the 1-bar level in Jupiter and 1100 km below that level in Saturn. Deviations of the DFT-EOS from SCVH are up to about +/- 5% depending on the pressure, and thus affect interior models at the same level as possible effects of a jovian core. We will discuss inferred core masses and interior metallicity for Jupiter and Saturn. Our results will eventually aid in interpretation of data expected from the Juno orbiter mission. Supported by NASA PGG Grants NAG5-13775 and PGG04-0000-0116 and NSF Grant 0507321.

  17. First principles calculation of point defects and mobility degradation in bulk AlSb for radiation detection application

    SciTech Connect

    Lordi, V; Aberg, D; Erhart, P; Wu, K J

    2007-07-30

    The development of high resolution, room temperature semiconductor radiation detectors requires the introduction of materials with increased carrier mobility-lifetime ({mu}{tau}) product, while having a band gap in the 1.4-2.2 eV range. AlSb is a promising material for this application. However, systematic improvements in the material quality are necessary to achieve an adequate {mu}{tau} product. We are using a combination of simulation and experiment to develop a fundamental understanding of the factors which affect detector material quality. First principles calculations are used to study the microscopic mechanisms of mobility degradation from point defects and to calculate the intrinsic limit of mobility from phonon scattering. We use density functional theory (DFT) to calculate the formation energies of native and impurity point defects, to determine their equilibrium concentrations as a function of temperature and charge state. Perturbation theory via the Born approximation is coupled with Boltzmann transport theory to calculate the contribution toward mobility degradation of each type of point defect, using DFT-computed carrier scattering rates. A comparison is made to measured carrier concentrations and mobilities from AlSb crystals grown in our lab. We find our predictions in good quantitative agreement with experiment, allowing optimized annealing conditions to be deduced. A major result is the determination of oxygen impurity as a severe mobility killer, despite the ability of oxygen to compensation dope AlSb and reduce the net carrier concentration. In this case, increased resistivity is not a good indicator of improved material performance, due to the concomitant sharp reduction in {mu}{tau}.

  18. Investigation of the interface in silica-encapsulated liposomes by combining solid state NMR and first principles calculations.

    PubMed

    Folliet, Nicolas; Roiland, Claire; Bégu, Sylvie; Aubert, Anne; Mineva, Tzonka; Goursot, Annick; Selvaraj, Kaliaperumal; Duma, Luminita; Tielens, Frederik; Mauri, Francesco; Laurent, Guillaume; Bonhomme, Christian; Gervais, Christel; Babonneau, Florence; Azaïs, Thierry

    2011-10-26

    In the context of nanomedicine, liposils (liposomes and silica) have a strong potential for drug storage and release schemes: such materials combine the intrinsic properties of liposome (encapsulation) and silica (increased rigidity, protective coating, pH degradability). In this work, an original approach combining solid state NMR, molecular dynamics, first principles geometry optimization, and NMR parameters calculation allows the building of a precise representation of the organic/inorganic interface in liposils. {(1)H-(29)Si}(1)H and {(1)H-(31)P}(1)H Double Cross-Polarization (CP) MAS NMR experiments were implemented in order to explore the proton chemical environments around the silica and the phospholipids, respectively. Using VASP (Vienna Ab Initio Simulation Package), DFT calculations including molecular dynamics, and geometry optimization lead to the determination of energetically favorable configurations of a DPPC (dipalmitoylphosphatidylcholine) headgroup adsorbed onto a hydroxylated silica surface that corresponds to a realistic model of an amorphous silica slab. These data combined with first principles NMR parameters calculations by GIPAW (Gauge Included Projected Augmented Wave) show that the phosphate moieties are not directly interacting with silanols. The stabilization of the interface is achieved through the presence of water molecules located in-between the head groups of the phospholipids and the silica surface forming an interfacial H-bonded water layer. A detailed study of the (31)P chemical shift anisotropy (CSA) parameters allows us to interpret the local dynamics of DPPC in liposils. Finally, the VASP/solid state NMR/GIPAW combined approach can be extended to a large variety of organic-inorganic hybrid interfaces.

  19. A variational principle in Wigner phase-space with applications to statistical mechanics

    NASA Astrophysics Data System (ADS)

    Poulsen, Jens Aage

    2011-01-01

    We consider the Dirac-Frenkel variational principle in Wigner phase-space and apply it to the Wigner-Liouville equation for both imaginary and real time dynamical problems. The variational principle allows us to deduce the optimal time-evolution of the parameter-dependent Wigner distribution. It is shown that the variational principle can be formulated alternatively as a "principle of least action." Several low-dimensional problems are considered. In imaginary time, high-temperature classical distributions are "cooled" to arrive at low-temperature quantum Wigner distributions whereas in real time, the coherent dynamics of a particle in a double well is considered. Especially appealing is the relative ease at which Feynman's path integral centroid variable can be incorporated as a variational parameter. This is done by splitting the high-temperature Boltzmann distribution into exact local centroid constrained distributions, which are thereafter cooled using the variational principle. The local distributions are sampled by Metropolis Monte Carlo by performing a random walk in the centroid variable. The combination of a Monte Carlo and a variational procedure enables the study of quantum effects in low-temperature many-body systems, via a method that can be systematically improved.

  20. 10 CFR 455.130 - State evaluation of grant applications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 455.130 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION GRANT PROGRAMS FOR SCHOOLS AND HOSPITALS AND...(b), any additional requirements of the approved State Plan, State environmental laws, and other applicable laws and regulations, then such application will be eligible for financial assistance....

  1. 32 CFR 1903.3 - State law applicable.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 6 2014-07-01 2014-07-01 false State law applicable. 1903.3 Section 1903.3 National Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY CONDUCT ON AGENCY INSTALLATIONS § 1903.3 State law applicable. (a) Unless specifically addressed by the...

  2. 32 CFR 1903.3 - State law applicable.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 6 2012-07-01 2012-07-01 false State law applicable. 1903.3 Section 1903.3 National Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY CONDUCT ON AGENCY INSTALLATIONS § 1903.3 State law applicable. (a) Unless specifically addressed by the...

  3. 32 CFR 1903.3 - State law applicable.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false State law applicable. 1903.3 Section 1903.3 National Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY CONDUCT ON AGENCY INSTALLATIONS § 1903.3 State law applicable. (a) Unless specifically addressed by the...

  4. 28 CFR 104.42 - Applicable state law.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Applicable state law. 104.42 Section 104.42 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) SEPTEMBER 11TH VICTIM COMPENSATION FUND OF 2001 Amount of Compensation for Eligible Claimants. § 104.42 Applicable state law. The phrase...

  5. 32 CFR 1903.3 - State law applicable.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false State law applicable. 1903.3 Section 1903.3 National Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY CONDUCT ON AGENCY INSTALLATIONS § 1903.3 State law applicable. (a) Unless specifically addressed by the...

  6. A Comparison of the Six Principles of the Individuals with Disabilities Education Improvement Act of the United States and the Persons with Disability Act of Ghana

    ERIC Educational Resources Information Center

    Mumuni, Samad Dimbie

    2010-01-01

    This study compared the six principles of IDEIA of the United States and the Persons with Disability Act of Ghana with the view to determining their similarities and differences. Recommendations were made with the ultimate aim of exploring the need for change in the special education delivery systems in the United States and Ghana. The comparative…

  7. Quantum valley Hall states and topological transitions in Pt(Ni, Pd)-decorated silicene: A first-principles study

    SciTech Connect

    Zhao, Bao; Zhang, Jiayong; Wang, Yicheng; Yang, Zhongqin

    2014-12-28

    The electronic states and topological behaviors of Pt(Ni, Pd)-decorated silicene are investigated by using an ab-initio method. All the three kinds of the adatoms prefer hollow sites of the silicene, guaranteeing the Dirac cones unbroken. The Pt(Ni, Pd)-decorated silicene systems all present quantum valley Hall (QVH) states with the gap opened exactly at the Fermi level. The gaps of the QVH states can be increased substantially by applying a positive electric field. Very fascinating phase transitions from QVH to quantum spin Hall (QSH) and then to QVH again are achieved in the Pt/Ni-decorated silicene when a negative electric field is applied. The QSH state in the Pd case with a negative electric field is, however, quenched because of relatively larger Rashba spin-orbit coupling (SOC) than the intrinsic SOC in the system. Our findings may be useful for the applications of silicene-based devices in valleytronics and spintronics.

  8. First-principles calculations of the equation of state and electrical conductivity of steel

    NASA Astrophysics Data System (ADS)

    Mattsson, Thomas R.; Desjarlais, Michael P.

    2003-10-01

    Quantum molecular dynamics based on density functional theory offers a new paradigm for determination of dense-plasma properties. The variation of pressure and electrical conductivity with density and temperature can be calculated without empirical input. For aluminum, our calculations [1] are in very good agreement with exploding wire data. Here we study stainless steel between 4000 and 30000 K using the same approach; spanning more than an order of magnitude in density. We focus on the thermophysical properties in the warm-dense matter region surrounding the critical point, which we determine to be around 9000 K. The electrical conductivity is calculated directly from the electronic wave functions, Ψ, using the Kubo-Greenwood formula, thus bypassing calculations of collision times and ionization degree. The results are being used to generate wide range EOS and conductivity tables (SESAME format) for use in HEDP modeling codes. Sandia is a multi-program laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy under Contract DE-AC04-94AL85000. [1] M. P. Desjarlais et al. Phys. Rev. E 66, 025401 (R) (2002).

  9. Emerging principles and neural substrates underlying tonic sleep-state-dependent influences on respiratory motor activity.

    PubMed

    Horner, Richard L

    2009-09-12

    Respiratory muscles with dual respiratory and non-respiratory functions (e.g. the pharyngeal and intercostal muscles) show greater suppression of activity in sleep than the diaphragm, a muscle almost entirely devoted to respiratory function. This sleep-related suppression of activity is most apparent in the tonic component of motor activity, which has functional implications of a more collapsible upper airspace in the case of pharyngeal muscles, and decreased functional residual capacity in the case of intercostal muscles. A major source of tonic drive to respiratory motoneurons originates from neurons intimately involved in states of brain arousal, i.e. neurons not classically involved in generating respiratory rhythm and pattern per se. The tonic drive to hypoglossal motoneurons, a respiratory motor pool with both respiratory and non-respiratory functions, is mediated principally by noradrenergic and glutamatergic inputs, these constituting the essential components of the wakefulness stimulus. These tonic excitatory drives are opposed by tonic inhibitory glycinergic and gamma-amino butyric acid (GABA) inputs that constrain the level of respiratory-related motor activity, with the balance determining net motor tone. In sleep, the excitatory inputs are withdrawn and GABA release into the brainstem is increased, thus decreasing respiratory motor tone and predisposing susceptible individuals to hypoventilation and obstructive sleep apnoea.

  10. Accurate First-Principles Spectra Predictions for Planetological and Astrophysical Applications at Various T-Conditions

    NASA Astrophysics Data System (ADS)

    Rey, M.; Nikitin, A. V.; Tyuterev, V.

    2014-06-01

    Knowledge of near infrared intensities of rovibrational transitions of polyatomic molecules is essential for the modeling of various planetary atmospheres, brown dwarfs and for other astrophysical applications 1,2,3. For example, to analyze exoplanets, atmospheric models have been developed, thus making the need to provide accurate spectroscopic data. Consequently, the spectral characterization of such planetary objects relies on the necessity of having adequate and reliable molecular data in extreme conditions (temperature, optical path length, pressure). On the other hand, in the modeling of astrophysical opacities, millions of lines are generally involved and the line-by-line extraction is clearly not feasible in laboratory measurements. It is thus suggested that this large amount of data could be interpreted only by reliable theoretical predictions. There exists essentially two theoretical approaches for the computation and prediction of spectra. The first one is based on empirically-fitted effective spectroscopic models. Another way for computing energies, line positions and intensities is based on global variational calculations using ab initio surfaces. They do not yet reach the spectroscopic accuracy stricto sensu but implicitly account for all intramolecular interactions including resonance couplings in a wide spectral range. The final aim of this work is to provide reliable predictions which could be quantitatively accurate with respect to the precision of available observations and as complete as possible. All this thus requires extensive first-principles quantum mechanical calculations essentially based on three necessary ingredients which are (i) accurate intramolecular potential energy surface and dipole moment surface components well-defined in a large range of vibrational displacements and (ii) efficient computational methods combined with suitable choices of coordinates to account for molecular symmetry properties and to achieve a good numerical

  11. Regulation of Spatiotemporal Patterns by Biological Variability: General Principles and Applications to Dictyostelium discoideum

    PubMed Central

    Grace, Miriam; Hütt, Marc-Thorsten

    2015-01-01

    Spatiotemporal patterns often emerge from local interactions in a self-organizing fashion. In biology, the resulting patterns are also subject to the influence of the systematic differences between the system’s constituents (biological variability). This regulation of spatiotemporal patterns by biological variability is the topic of our review. We discuss several examples of correlations between cell properties and the self-organized spatiotemporal patterns, together with their relevance for biology. Our guiding, illustrative example will be spiral waves of cAMP in a colony of Dictyostelium discoideum cells. Analogous processes take place in diverse situations (such as cardiac tissue, where spiral waves occur in potentially fatal ventricular fibrillation) so a deeper understanding of this additional layer of self-organized pattern formation would be beneficial to a wide range of applications. One of the most striking differences between pattern-forming systems in physics or chemistry and those in biology is the potential importance of variability. In the former, system components are essentially identical with random fluctuations determining the details of the self-organization process and the resulting patterns. In biology, due to variability, the properties of potentially very few cells can have a driving influence on the resulting asymptotic collective state of the colony. Variability is one means of implementing a few-element control on the collective mode. Regulatory architectures, parameters of signaling cascades, and properties of structure formation processes can be "reverse-engineered" from observed spatiotemporal patterns, as different types of regulation and forms of interactions between the constituents can lead to markedly different correlations. The power of this biology-inspired view of pattern formation lies in building a bridge between two scales: the patterns as a collective state of a very large number of cells on the one hand, and the internal

  12. 45 CFR 1080.5 - Application procedures for States.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... HOMELESS GRANT PROGRAM § 1080.5 Application procedures for States. (a) Each State requesting funds under the Emergency Community Services Homeless Grant Program shall submit to the Office of Community... homeless individuals administered by the State; (3) Not more than 5 percent of the amount received will...

  13. 45 CFR 1080.5 - Application procedures for States.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... HOMELESS GRANT PROGRAM § 1080.5 Application procedures for States. (a) Each State requesting funds under the Emergency Community Services Homeless Grant Program shall submit to the Office of Community... homeless individuals administered by the State; (3) Not more than 5 percent of the amount received will...

  14. 45 CFR 800.114 - Compliance with applicable State law.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 3 2013-10-01 2013-10-01 false Compliance with applicable State law. 800.114 Section 800.114 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF PERSONNEL MANAGEMENT MULTI-STATE PLAN PROGRAM Multi-State Plan Program Issuer Requirements § 800.114 Compliance...

  15. 45 CFR 800.114 - Compliance with applicable State law.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 3 2014-10-01 2014-10-01 false Compliance with applicable State law. 800.114 Section 800.114 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF PERSONNEL MANAGEMENT MULTI-STATE PLAN PROGRAM Multi-State Plan Program Issuer Requirements § 800.114 Compliance...

  16. Substituting a judgment of best interests: dignity and the application of objective principles to PVS cases in the U.K.

    PubMed

    Pradella, Geoffrey M

    2005-12-01

    The mêlée that surrounded the last days of Terri Schiavo's life was reminiscent of a classical Greek tragedy. Much like Antigone, Ms. Schiavo became enmeshed in irresistible and opposite forces, resolved to use her situation as an arena for the determination of political and legal issues as diverse as the exercise of states' rights, the extent of individual rights, the role of the judiciary, the re-opening of the abortion debate, and the regulation of stem cell research. As Europeans watched the drama unfold, the forces at play in the United States clashed head-on, in a rhetorically inflammatory spectacle which, on this side of the Atlantic, left many aghast. Most unsettling was the prospect of individuals wielding the power of state and national legislatures in what was, ultimately, an intensely personal affair. In the United Kingdom, the struggle was a stark reminder of the differences, not only between British and American political culture, but between our approaches to legal issues which present themselves at the end of life. The existence of well-established procedures and principles, and the extensive involvement of neutral third parties and the courts in pursuit of an objective determination of an individual patient's 'best interests', are key to the conclusion that Terri Schiavo's case would have been handled at least as effectively and efficiently as it was by the courts in Florida and the United States. That issues of consent and capacity can be determined by British courts on the basis of generally applicable principles leads to the subsequent conclusion that a 'best interests' determination leaves significantly less scope for conflict than the individualistic, much more personal and determinative construct of the 'substituted judgment' test in the United States.

  17. The On-Line Application of Binding Principle A in English as a Second Language

    ERIC Educational Resources Information Center

    Felser, Claudia; Sato, Mikako; Bertenshaw, Nicholas

    2009-01-01

    We report the results from two experiments investigating proficient Japanese-speaking learners' processing of reflexive object pronouns in English as a second language (L2). Experiment 1 used a timed grammaticality judgement task to assess learners' sensitivity to binding Principle A under processing pressure, and Experiment 2 investigated the…

  18. Principled Eclecticism: Approach and Application in Teaching Writing to ESL/EFL Students

    ERIC Educational Resources Information Center

    Alharbi, Sultan H.

    2017-01-01

    The principal purpose of this paper is to critically examine and evaluate the efficacy of the principled eclectic approach to teaching English as second/foreign language (ESL/EFL) writing to undergraduate students. The paper illustrates that this new method adapts mainstream writing pedagogies to individual needs of learners of ESL/EFL in order to…

  19. An Empirical Study of the Application of Psychological Principles to the Teaching of Orienteering.

    ERIC Educational Resources Information Center

    Martland, J. R.

    1983-01-01

    An empirical study was carried out to explore effects of three sets of schedules developed by Edgar Stones as guidelines conducive to student learning. Guidelines for concept teaching, psychomotor skill development, and teaching problem solving formed the instructional framework for teaching 11-year-old children the principles of navigational…

  20. Pivotal Response Treatment for Children with Autism: Core Principles and Applications for School Psychologists

    ERIC Educational Resources Information Center

    Renshaw, Tyler L.; Kuriakose, Sarah

    2011-01-01

    During the past 2 decades, pivotal response treatment (PRT) has emerged as an evidence-based methodology for intervening with the behavioral, communicative, social, and academic impairments of children with autism. Unlike other highly structured behavioral interventions for autism, PRT emphasizes principles over procedures and focuses on enhancing…

  1. Maximum Principles and Application to the Analysis of An Explicit Time Marching Algorithm

    NASA Technical Reports Server (NTRS)

    LeTallec, Patrick; Tidriri, Moulay D.

    1996-01-01

    In this paper we develop local and global estimates for the solution of convection-diffusion problems. We then study the convergence properties of a Time Marching Algorithm solving Advection-Diffusion problems on two domains using incompatible discretizations. This study is based on a De-Giorgi-Nash maximum principle.

  2. Application of Hamilton's Principle to the Study of the Anharmonic Oscillator in Classical Mechanics.

    ERIC Educational Resources Information Center

    And Others; Gilmartin, Harvey

    1979-01-01

    Presented is a form of Hamilton's principle for classical mechanics appropriate to the study of arbitrary self-sustained vibrations in one dimension. It is applied as an approximate computational tool to the study of several examples of anharmonic oscillation. (Author/GA)

  3. Applications of Contingency Management Principles to the College Classroom: The Con Game Project.

    ERIC Educational Resources Information Center

    Swenson, Leland C.

    A system of teaching based on the principles of the Token economy was developed. This system allowed students to choose not only the pace at which they would advance through a curriculae but also allowed them the choice of output mode (paper versus tests) and areas of concentration. By rewarding student participation in helping to find educational…

  4. Application of Multimedia Design Principles to Visuals Used in Course-Books: An Evaluation Tool

    ERIC Educational Resources Information Center

    Kuzu, Abdullah; Akbulut, Yavuz; Sahin, Mehmet Can

    2007-01-01

    This paper introduces an evaluation tool prepared to examine the quality of visuals in course-books. The tool is based on Mayer's Cognitive Theory of Multimedia Learning (i.e. Generative Theory) and its principles regarding the correct use of illustrations within text. The reason to generate the tool, the development process along with the…

  5. Administering Our State Library Agencies

    ERIC Educational Resources Information Center

    DuFrane, Gerard

    1970-01-01

    A satire on the application of scientific management principles to a state library agency. Covers relationships of the state librarian to staff, the profession, and state and federal governments. (Author/JS)

  6. Applications of electromagnetic principles in the design and development of proximity wireless sensors

    NASA Astrophysics Data System (ADS)

    Alam, Md Nazmul

    Sensors and sensing system are playing dominant roles in monitoring the health of infrastructure, such as bridges, power lines, gas pipelines, rail roads etc. Sensing modalities employing Surface Acoustic Waves (SAW), Electromagnetic (EM) and optical have been investigated and reported. Sensors that utilize the perturbation of EM fields as function of the change in the physical structural or material phenomenon are of particular interest because of their inherent synergy with electronic system and diagnostic techniques, e.g. Time Domain Reflectometry (TDR), Joint-Time-Frequency-Domain-Reflectometry (JTFDR). The focus of this work is to study and develop new sensing and monitoring concepts that are based on EM principles. First, the analyses, design and development of a static electric field type sensor are presented for application in embedded concrete moisture content measurement. The analytical formulation and results based on conformal mapping method for an interdigitated sensor clearly show the dependency of the field penetration depth and the inter-electrode capacitance on the electrode sizes and their spacings. It is observed that larger electrode size and small separation are needed in order to achieve substantially higher capacitance or large field penetration depth. A meander and a circular sensor are fabricated and tested to demonstrate concrete moisture content measurements that show that moisture content is a linear function of sensor interelectrode capacitance. Second, sub-wavelength dimension non-intrusive wave launchers are designed and tested that can launch TDR or JTFDR type broadband surface wave waveforms in the VHF-UHF bands in order to detect cable faults. Greater than 3:1 transmission bandwidth (100-300 MHz) is obtained with a cylindrical launcher on square orthogonal ground plane while with a CSW launcher more than an octave (100-240 MHz) bandwidth is achieved. Open circuit faults are detected using surface waves and TDR on two XLPE cables

  7. Large-Scale First-Principles Molecular Dynamics Simulations with Electrostatic Embedding: Application to Acetylcholinesterase Catalysis.

    PubMed

    Fattebert, Jean-Luc; Lau, Edmond Y; Bennion, Brian J; Huang, Patrick; Lightstone, Felice C

    2015-12-08

    Enzymes are complicated solvated systems that typically require many atoms to simulate their function with any degree of accuracy. We have recently developed numerical techniques for large scale first-principles molecular dynamics simulations and applied them to the study of the enzymatic reaction catalyzed by acetylcholinesterase. We carried out density functional theory calculations for a quantum-mechanical (QM) subsystem consisting of 612 atoms with an O(N) complexity finite-difference approach. The QM subsystem is embedded inside an external potential field representing the electrostatic effect due to the environment. We obtained finite-temperature sampling by first-principles molecular dynamics for the acylation reaction of acetylcholine catalyzed by acetylcholinesterase. Our calculations show two energy barriers along the reaction coordinate for the enzyme-catalyzed acylation of acetylcholine. The second barrier (8.5 kcal/mol) is rate-limiting for the acylation reaction and in good agreement with experiment.

  8. Application of the generalized quasi-complementary energy principle to the fluid-solid coupling problem

    NASA Astrophysics Data System (ADS)

    Liang, Li-Fu; Liu, Zong-Min; Guo, Qing-Yong

    2009-03-01

    The fluid-solid coupling theory, an interdisciplinary science between hydrodynamics and solid mechanics, is an important tool for response analysis and direct design of structures in naval architecture and ocean engineering. By applying the corresponding relations between generalized forces and generalized displacements, convolutions were performed between the basic equations of elasto-dynamics in the primary space and corresponding virtual quantities. The results were integrated and then added algebraically. In light of the fact that body forces and surface forces are both follower forces, the generalized quasi-complementary energy principle with two kinds of variables for an initial value problem is established in non-conservative systems. Using the generalized quasi-complementary energy principle to deal with the fluid-solid coupling problem and to analyze the dynamic response of structures, a method for using two kinds of variables simultaneously for calculation of force and displacement was derived.

  9. Rational, computer-enabled peptide drug design: principles, methods, applications and future directions.

    PubMed

    Diller, David J; Swanson, Jon; Bayden, Alexander S; Jarosinski, Mark; Audie, Joseph

    2015-01-01

    Peptides provide promising templates for developing drugs to occupy a middle space between small molecules and antibodies and for targeting 'undruggable' intracellular protein-protein interactions. Importantly, rational or in cerebro design, especially when coupled with validated in silico tools, can be used to efficiently explore chemical space and identify islands of 'drug-like' peptides to satisfy diverse drug discovery program objectives. Here, we consider the underlying principles of and recent advances in rational, computer-enabled peptide drug design. In particular, we consider the impact of basic physicochemical properties, potency and ADME/Tox opportunities and challenges, and recently developed computational tools for enabling rational peptide drug design. Key principles and practices are spotlighted by recent case studies. We close with a hypothetical future case study.

  10. Large-Scale First-Principles Molecular Dynamics Simulations with Electrostatic Embedding: Application to Acetylcholinesterase Catalysis

    DOE PAGES

    Fattebert, Jean-Luc; Lau, Edmond Y.; Bennion, Brian J.; ...

    2015-10-22

    Enzymes are complicated solvated systems that typically require many atoms to simulate their function with any degree of accuracy. We have recently developed numerical techniques for large scale First-Principles molecular dynamics simulations and applied them to study the enzymatic reaction catalyzed by acetylcholinesterase. We carried out Density functional theory calculations for a quantum mechanical (QM) sub- system consisting of 612 atoms with an O(N) complexity finite-difference approach. The QM sub-system is embedded inside an external potential field representing the electrostatic effect due to the environment. We obtained finite temperature sampling by First-Principles molecular dynamics for the acylation reaction of acetylcholinemore » catalyzed by acetylcholinesterase. Our calculations shows two energies barriers along the reaction coordinate for the enzyme catalyzed acylation of acetylcholine. In conclusion, the second barrier (8.5 kcal/mole) is rate-limiting for the acylation reaction and in good agreement with experiment.« less

  11. Large-Scale First-Principles Molecular Dynamics Simulations with Electrostatic Embedding: Application to Acetylcholinesterase Catalysis

    SciTech Connect

    Fattebert, Jean-Luc; Lau, Edmond Y.; Bennion, Brian J.; Huang, Patrick; Lightstone, Felice C.

    2015-10-22

    Enzymes are complicated solvated systems that typically require many atoms to simulate their function with any degree of accuracy. We have recently developed numerical techniques for large scale First-Principles molecular dynamics simulations and applied them to study the enzymatic reaction catalyzed by acetylcholinesterase. We carried out Density functional theory calculations for a quantum mechanical (QM) sub- system consisting of 612 atoms with an O(N) complexity finite-difference approach. The QM sub-system is embedded inside an external potential field representing the electrostatic effect due to the environment. We obtained finite temperature sampling by First-Principles molecular dynamics for the acylation reaction of acetylcholine catalyzed by acetylcholinesterase. Our calculations shows two energies barriers along the reaction coordinate for the enzyme catalyzed acylation of acetylcholine. In conclusion, the second barrier (8.5 kcal/mole) is rate-limiting for the acylation reaction and in good agreement with experiment.

  12. Application of Maximum Entropy principle to modeling torsion angle probability distribution in proteins

    NASA Astrophysics Data System (ADS)

    Rowicka, Małgorzata; Otwinowski, Zbyszek

    2004-04-01

    Using the Maximum Entropy principle, we find probability distribution of torsion angles in proteins. We estimate parameters of this distribution numerically, by implementing the conjugate gradient method in Polak-Ribiere variant. We investigate practical approximations of the theoretical distribution. We discuss the information content of these approximations and compare them with standard histogram method. Our data are pairs of main chain torsion angles for a selected subset of high resolution non-homologous protein structures from Protein Data Bank.

  13. Application of Instructional Design Principles in Developing an Online Information Literacy Curriculum.

    PubMed

    Mi, Misa

    2016-01-01

    An online information literacy curriculum was developed as an intervention to engage students in independent study and self-assessment of their learning needs and learning outcomes, develop proficiency in information skills, and foster lifelong learning. This column demonstrates how instructional design principles were applied to create the learning experiences integrated into various courses of the medical curriculum to promote active learning of information skills and maximize self-directed learning outcomes for lifelong learning.

  14. 10 CFR 420.13 - Annual State applications and amendments to State plans.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., renewable energy, and alternative transportation fuel goals to be achieved, including wherever practicable... 10 Energy 3 2011-01-01 2011-01-01 false Annual State applications and amendments to State plans. 420.13 Section 420.13 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION STATE ENERGY PROGRAM...

  15. 10 CFR 420.13 - Annual State applications and amendments to State plans.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., renewable energy, and alternative transportation fuel goals to be achieved, including wherever practicable... 10 Energy 3 2013-01-01 2013-01-01 false Annual State applications and amendments to State plans. 420.13 Section 420.13 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION STATE ENERGY PROGRAM...

  16. 40 CFR Appendix A to Subpart Aaaa... - States With Approved State Implementation Plan Revisions Concerning Applicability

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 22 2013-07-01 2013-07-01 false States With Approved State Implementation Plan Revisions Concerning Applicability A Appendix A to Subpart AAAA of Part 97 Protection of.... 97, Subpt. AAAA, App. A Appendix A to Subpart AAAA of Part 97—States With Approved...

  17. 10 CFR 420.13 - Annual State applications and amendments to State plans.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., renewable energy, and alternative transportation fuel goals to be achieved, including wherever practicable... 10 Energy 3 2010-01-01 2010-01-01 false Annual State applications and amendments to State plans. 420.13 Section 420.13 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION STATE ENERGY PROGRAM...

  18. 10 CFR 420.13 - Annual State applications and amendments to State plans.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., renewable energy, and alternative transportation fuel goals to be achieved, including wherever practicable... 10 Energy 3 2012-01-01 2012-01-01 false Annual State applications and amendments to State plans. 420.13 Section 420.13 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION STATE ENERGY PROGRAM...

  19. First-principles screening of complex transition metal hydrides for high temperature applications.

    PubMed

    Nicholson, Kelly M; Sholl, David S

    2014-11-17

    Metal hydrides with enhanced thermodynamic stability with respect to the associated binary hydrides are useful for high temperature applications in which highly stable materials with low hydrogen overpressures are desired. Though several examples of complex transition metal hydrides (CTMHs) with such enhanced stability are known, little thermodynamic or phase stability information is available for this materials class. In this work, we use semiautomated thermodynamic and phase diagram calculations based on density functional theory (DFT) and grand canonical linear programming (GCLP) methods to screen 102 ternary and quaternary CTMHs and 26 ternary saline hydrides in a library of over 260 metals, intermetallics, binary, and higher hydrides to identify materials that release hydrogen at higher temperatures than the associated binary hydrides and at elevated temperatures, T > 1000 K, for 1 bar H2 overpressure. For computational efficiency, we employ a tiered screening approach based first on solid phase ground state energies with temperature effects controlled via H2 gas alone and second on the inclusion of phonon calculations that correct solid phase free energies for temperature-dependent vibrational contributions. We successfully identified 13 candidate CTMHs including Eu2RuH6, Yb2RuH6, Ca2RuH6, Ca2OsH6, Ba2RuH6, Ba3Ir2H12, Li4RhH4, NaPd3H2, Cs2PtH4, K2PtH4, Cs3PtH5, Cs3PdH3, and Rb2PtH4. The most stable CTMHs tend to crystallize in the Sr2RuH6 cubic prototype structure and decompose to the pure elements and hydrogen rather than to intermetallic phases.

  20. Application of Smart Solid State Sensor Technology in Aerospace Applications

    NASA Technical Reports Server (NTRS)

    Hunter, Gary W.; Xu, Jennifer C.; Dungan, L.K.; Makel, D.; Ward, B.; Androjna, D.

    2008-01-01

    Aerospace applications require a range of chemical sensing technologies to monitor conditions in both space vehicles and aircraft operations. One example is the monitoring of oxygen. For example, monitoring of ambient oxygen (O2) levels is critical to ensuring the health, safety, and performance of humans living and working in space. Oxygen sensors can also be incorporated in detection systems to determine if hazardous leaks are occurring in space propulsion systems and storage facilities. In aeronautic applications, O2 detection has been investigated for fuel tank monitoring. However, as noted elsewhere, O2 is not the only species of interest in aerospace applications with a wide range of species of interest being relevant to understand an environmental or vehicle condition. These include combustion products such as CO, HF, HCN, and HCl, which are related to both the presence of a fire and monitoring of post-fire clean-up operations. This paper discusses the development of an electrochemical cell platform based on a polymer electrolyte, NAFION, and a three-electrode configuration. The approach has been to mature this basic platform for a range of applications and to test this system, combined with "Lick and Stick" electronics, for its viability to monitor an environment related to astronaut crew health and safety applications with an understanding that a broad range of applications can be addressed with a core technology.

  1. State-Based Implicit Coordination and Applications

    NASA Technical Reports Server (NTRS)

    Narkawicz, Anthony J.; Munoz, Cesar A.

    2011-01-01

    In air traffic management, pairwise coordination is the ability to achieve separation requirements when conflicting aircraft simultaneously maneuver to solve a conflict. Resolution algorithms are implicitly coordinated if they provide coordinated resolution maneuvers to conflicting aircraft when only surveillance data, e.g., position and velocity vectors, is periodically broadcast by the aircraft. This paper proposes an abstract framework for reasoning about state-based implicit coordination. The framework consists of a formalized mathematical development that enables and simplifies the design and verification of implicitly coordinated state-based resolution algorithms. The use of the framework is illustrated with several examples of algorithms and formal proofs of their coordination properties. The work presented here supports the safety case for a distributed self-separation air traffic management concept where different aircraft may use different conflict resolution algorithms and be assured that separation will be maintained.

  2. 31 CFR 50.24 - Applicability of State law requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... RISK INSURANCE PROGRAM Mandatory Availability § 50.24 Applicability of State law requirements. (a... permits certain exclusions or allows for other limitations, or an insurance policy is not governed...

  3. Multi-Case Review of the Application of the Precautionary Principle in European Union Law and Case Law.

    PubMed

    Garnett, Kenisha; Parsons, David J

    2016-05-18

    The precautionary principle was formulated to provide a basis for political action to protect the environment from potentially severe or irreversible harm in circumstances of scientific uncertainty that prevent a full risk or cost-benefit analysis. It underpins environmental law in the European Union and has been extended to include public health and consumer safety. The aim of this study was to examine how the precautionary principle has been interpreted and subsequently applied in practice, whether these applications were consistent, and whether they followed the guidance from the Commission. A review of the literature was used to develop a framework for analysis, based on three attributes: severity of potential harm, standard of evidence (or degree of uncertainty), and nature of the regulatory action. This was used to examine 15 pieces of legislation or judicial decisions. The decision whether or not to apply the precautionary principle appears to be poorly defined, with ambiguities inherent in determining what level of uncertainty and significance of hazard justifies invoking it. The cases reviewed suggest that the Commission's guidance was not followed consistently in forming legislation, although judicial decisions tended to be more consistent and to follow the guidance by requiring plausible evidence of potential hazard in order to invoke precaution.

  4. First-principles study of intercalation of alkali ions in FeSe for solid-state batteries

    NASA Astrophysics Data System (ADS)

    Jiang, Zhiqiang; Gu, Xiao; Wang, Linxia; Huang, Li

    2016-08-01

    Electrochemical properties of alkali ions (Li+, Na+, and K+) intercalating into FeSe have been studied based on first-principles calculations within density functional theory. The intercalation sites of lithium ions are found to be different from sodium and potassium ions due to the small ionic radius of lithium. Calculations of minimum energy path on the diffusions of Li+, Na+, and K+ in FeSe show that the activation energies for those alkali ions increase with their ionic radii. Lithium ions have a rather smaller diffusion barrier of about 0.20 eV, which leads to a bigger diffusion coefficient of about 6.3 ×10-6cm2 /s . We also show that FeSe has a flat discharging stage at about 1.0 V with lithium ions. These results indicate that XFe2Se2 (X = Li, Na, K) may be potential electrochemical active materials, especially for solid-state electrolyte and supercapacitors.

  5. Basic principles of the KIV model and its application to the navigation problem.

    PubMed

    Kozma, Robert; Freeman, Walter J

    2003-06-01

    EEG measurements indicate the presence of common-mode, coherent oscillations shared by multiple cortical areas. In previous studies the KIII model has been introduced, which interprets the experimental observations as nonlinear, spatially distributed dynamical oscillations of locally coupled neural populations. KIII can account for the fast and robust classification and pattern recognition in sensory cortices. In order to describe selection of action, planning, and spatial orientation functions, in this paper we expand KIII into the KIV model. KIV approximates the operation of the corticostriatal-hippocampal system. KIV consists of three KI, eight KII and three KIII components, including sensory and cortical systems, as well as the hippocampus, amygdala, and the septum. KIV implements various types of dynamic neural activities. The neural activity patterns determine the emergence of global spatial encoding to implement the orientation function of a simulated animal. Our results indicate the mechanisms, which we believe support the generation of cognitive maps in the hippocampus based on the sensory input-based destabilization of cortical spatio-temporal patterns. In this paper, we describe the conceptual design of the KIV model. We outline the biological background and motivation of the basic principles that are applied to design the KIV computational model. We use the KIV model to explain how the hippocampal neural circuitry functions are constructed and controlled by the corticostriatal-hippocampal loops, supplemented with specific subcortical units. In the second part, we implement these principles using the example of the hippocampal formation as a KIII unit. We demonstrate the learning and navigation principles using the Evolving Multi-module Mobile Agent (EMMA) in 2D software environment.

  6. Application of the principles of evidence-based medicine to laboratory medicine.

    PubMed

    Price, Christopher P

    2003-07-15

    The principles of evidence-based medicine and the consequent search for robust evidence on outcomes plays a central role in the practice of laboratory medicine. The core of the evidence lies in an explicit recognition of the clinical question(s) that the test result can address. Studies that focus on the relevant patient cohort and clinical setting for the test, and identify the appropriate outcome measure will generate information that can be used to guide use of the test, identify the benefits, and thereby support the case for investment of resources to deliver the service.

  7. Principles and Applications of Solid Polymer Electrolyte Reactors for Electrochemical Hydrodehalogenation of Organic Pollutants

    NASA Astrophysics Data System (ADS)

    Cheng, Hua; Scott, Keith

    The ability to re-cycle halogenated liquid wastes, based on electrochemical hydrodehalogenation (EHDH), will provide a significant economic advantage and will reduce the environmental burden in a number of processes. The use of a solid polymer electrolyte (SPE) reactor is very attractive for this purpose. Principles and features of electrochemical HDH technology and SPE EHDH reactors are described. The SPE reactor enables selective dehalogenation of halogenated organic compounds in both aqueous and non-aqueous media with high current efficiency and low energy consumption. The influence of operating conditions, including cathode material, current density, reactant concentration and temperature on the HDH process and its stability are examined.

  8. From First Principles: The Application of Quantum Mechanics to Complex Molecules and Solvated Systems

    SciTech Connect

    Freitag, Mark A.

    2001-12-31

    The major title of this dissertation, 'From first principles,' is a phase often heard in the study of thermodynamics and quantum mechanics. These words embody a powerful idea in the physical sciences; namely, that it is possible to distill the complexities of nature into a set of simple, well defined mathematical laws from which specific relations can then be derived . In thermodynamics, these fundamental laws are immediately familiar to the physical scientist by their numerical order: the First, Second and Third Laws. However, the subject of the present volume is quantum mechanics-specifically, non-relativistic quantum mechanics, which is appropriate for most systems of chemical interest.

  9. Determination of effective brain connectivity from functional connectivity with application to resting state connectivities

    NASA Astrophysics Data System (ADS)

    Robinson, P. A.; Sarkar, S.; Pandejee, Grishma Mehta; Henderson, J. A.

    2014-07-01

    Neural field theory insights are used to derive effective brain connectivity matrices from the functional connectivity matrix defined by activity covariances. The symmetric case is exactly solved for a resting state system driven by white noise, in which strengths of connections, often termed effective connectivities, are inferred from functional data; these include strengths of connections that are underestimated or not detected by anatomical imaging. Proximity to criticality is calculated and found to be consistent with estimates obtainable from other methods. Links between anatomical, effective, and functional connectivity and resting state activity are quantified, with applicability to other complex networks. Proof-of-principle results are illustrated using published experimental data on anatomical connectivity and resting state functional connectivity. In particular, it is shown that functional connection matrices can be used to uncover the existence and strength of connections that are missed from anatomical connection matrices, including interhemispheric connections that are difficult to track with techniques such as diffusion spectrum imaging.

  10. Application of fluid dynamics principles in tilted permeable media to terrestrial hydrothermal systems

    SciTech Connect

    Criss, R.E.; Hofmeister, A.M.

    1991-02-01

    Fluid dynamics principles require that circulation of aqueous fluid will be practically ubiquitous in tectonically active parts of the Earth's crust and upper mantle. Both experiment and theory demonstrate that flow, generally in the form of unicells (Hadley circulation), always occurs for isothermal tilts above a very small critical angle ({approximately}5{degree}), for any non-zero permeability or Rayleigh number, and even for hot over cold geometries. Interestingly, heat transport rates in the unicellular regime are essentially conductive, so such flow, unlike more vigorous flow at higher Rayleigh number, is not properly termed convective. These principles have numerous geological ramifications, including: (1) many of the hydrothermal systems developed around epizonal intrusions should be dominantly unicellular in nature, which explains their aspect ratios and the smooth and very regular {delta}{sup 18}O variations that are produced in the rocks; (2) large, long-lived unicells are predicted to occur deep in the Earth's crust wherever Rayleigh numbers are finite and isotherms are substantially inclined, as in zones of batholith intrusion, regional metamorphism, and collision; (3) unicells with lateral dimensions of several hundred kilometers are predicted to be associated with subduction zones dipping more than 6-12{degree}, with fluid advection into the hot mantle wedge being instrumental in mantle metasomatism and in the generation of andesitic magmas.

  11. Prosthetic EMG control enhancement through the application of man-machine principles

    NASA Technical Reports Server (NTRS)

    Simcox, W. A.

    1977-01-01

    An area in medicine that appears suitable to man-machine principles is rehabilitation research, particularly when the motor aspects of the body are involved. If one considers the limb, whether functional or not, as the machine, the brain as the controller and the neuromuscular system as the man-machine interface, the human body is reduced to a man-machine system that can benefit from the principles behind such systems. The area of rehabilitation that this paper deals with is that of an arm amputee and his prosthetic device. Reducing this area to its man-machine basics, the problem becomes one of attaining natural multiaxis prosthetic control using Electromyographic activity (EMG) as the means of communication between man and prothesis. In order to use EMG as the communication channel it must be amplified and processed to yield a high information signal suitable for control. The most common processing scheme employed is termed Mean Value Processing. This technique for extracting the useful EMG signal consists of a differential to single ended conversion to the surface activity followed by a rectification and smoothing.

  12. A new class of equivalence principle test masses, with application to SR-POEM

    NASA Astrophysics Data System (ADS)

    Reasenberg, Robert D.

    2014-09-01

    We describe a new class of test masses (TMs) for use in a Galilean test of the equivalence principle, principally in space. These TMs have n\\geqslant 2 vertical bars that are joined by an off-center connector. A pair of TMs will be positioned to have interleaved bars. For n\\geqslant 3, the principal moments of inertia of a TM can be made equal. With their centers of mass aligned, a TM pair shows decreasing susceptibility to differential acceleration from local mass as n increases. For the Sounding Rocket based Principle Of Equivalence Measurement (SR-POEM), the mission requirements are well met with n=3, but not met with n=2. For a 1 kg SR-POEM TM, vibration frequencies can be made to be above 1 kHz and thus not interfere with the operation of the TM suspension system. The SR-POEM housing supports electrodes for a set of capacitance gauges that observes all six kinematic degrees of freedom of each TM.

  13. Using Simulation in Nursing PhD Education: Facilitating Application of Responsible Conduct of Research Principles.

    PubMed

    Clayton, Margaret F; Supiano, Katherine; Wilson, Rebecca; Lassche, Madeline; Latendresse, Gwen

    Simulation is a standard clinical nursing educational approach; however, simulation is rarely used in nonclinical nursing education. In doctor of philosophy (PhD) programs, ethical content about responsible conduct of research (RCR) is traditionally didactic, presented early in the program of study. Ethics content merits review before students begin the dissertation phase; thus, the purpose of this project was to design and implement simulated scenarios to help students apply RCR principles prior to beginning independent research. Two scenarios were developed: (a) a potential protocol change discussed in a research team meeting and (b) an in-home data collection experience with an elderly participant and her daughter. Actors were trained faculty volunteers, playing roles outside their usual academic positions. Faculty facilitated scenarios by posing questions as cues related to desired learning outcomes as scenarios unfolded. Eleven nursing PhD students and 6 faculty participated. Debriefing facilitated discussion of RCR principles, common research quandaries, and suggested scenario revisions. Faculty, expert observation, and video-review showed that younger and less experienced students tried to give the "right" answer rather than implement RCR appropriate solutions. Students with more clinical experience had difficulty adopting the less familiar researcher role. Overall, simulation is a novel and useful way to enhance RCR content in PhD programs.

  14. 12 CFR 34.4 - Applicability of state law.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... “crimes defined and punishable at common law or by the general statutes of a state and crimes and offences... legitimate power to define and punish crimes by general laws applicable to all persons within its jurisdiction * * *. But it is without lawful power to make such special laws applicable to banks organized...

  15. 28 CFR 33.61 - Review of State applications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Section 33.61 Judicial Administration DEPARTMENT OF JUSTICE BUREAU OF JUSTICE ASSISTANCE GRANT PROGRAMS Criminal Justice Block Grants Submission and Review of Applications § 33.61 Review of State applications... the Justice Assistance Act and the regulations of the Bureau of Justice Assistance. Section...

  16. Residency Applicants Misinterpret Their United States Medical Licensing Exam Scores

    ERIC Educational Resources Information Center

    Jones, Roger C.; Desbiens, Norman A.

    2009-01-01

    Proper interpretation of the results of the United States Medical Licensing Exam (USMLE) is important for program directors, residents, and faculty who advise applicants about applying for residency positions. We suspected that applicants often misinterpreted their performance in relationship to others who took the same examination. In 2005, 54…

  17. 10 CFR 455.131 - State ranking of grant applications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ....131 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION GRANT PROGRAMS FOR SCHOOLS AND HOSPITALS AND... least 30 percent of the total funds allocated for schools and hospitals to the State in any grant... hospitals to the State in any grant program cycle. (g) If there are insufficient applications from...

  18. 10 CFR 455.131 - State ranking of grant applications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... State Plan; (3) The types of energy sources to which conversion is proposed, including renewable energy... technical assistance and energy conservation measures including renewable resource measures to the extent... 10 Energy 3 2013-01-01 2013-01-01 false State ranking of grant applications. 455.131 Section...

  19. 10 CFR 455.131 - State ranking of grant applications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... State Plan; (3) The types of energy sources to which conversion is proposed, including renewable energy... technical assistance and energy conservation measures including renewable resource measures to the extent... 10 Energy 3 2012-01-01 2012-01-01 false State ranking of grant applications. 455.131 Section...

  20. 10 CFR 455.131 - State ranking of grant applications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... State Plan; (3) The types of energy sources to which conversion is proposed, including renewable energy... technical assistance and energy conservation measures including renewable resource measures to the extent... 10 Energy 3 2011-01-01 2011-01-01 false State ranking of grant applications. 455.131 Section...

  1. 10 CFR 455.131 - State ranking of grant applications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... State Plan; (3) The types of energy sources to which conversion is proposed, including renewable energy... technical assistance and energy conservation measures including renewable resource measures to the extent... 10 Energy 3 2010-01-01 2010-01-01 false State ranking of grant applications. 455.131 Section...

  2. Duality of Educational Policy as Global and Local: The Case of the Gender Equity Agenda in National Principles and State Actions

    ERIC Educational Resources Information Center

    Ham, Seung-Hwan; Paine, Lynn W.; Cha, Yun-Kyung

    2011-01-01

    This study provides cross-national empirical evidence that substantiates the dialectic relationship between global and local contexts with regard to educational gender equity both as a national principle and as a priority for state action. Cross-national data on educational gender equity policies across 160 countries were gathered from…

  3. State-of-the-art review of the applications of nanotechnology in pavement materials

    NASA Astrophysics Data System (ADS)

    Castillo, Luis, Jr.

    The use of nanotechnology in pavement materials is one main area that shows great promise and has the potential to change commonly used materials. This will develop more effective solutions to achieve the desired performance. The overall objective of this work is to present a state-of-the-art literature review of nano-science-based principles to improve the performance and, ultimately, the life cycle of transportation construction materials. This work will be organized into two different parts. The first part will consist of six sections: applications of nanotechnology in concrete pavements, applications of nanotechnology in asphalt pavement, application of nanotechnology in general soils, cost-benefit analysis, challenges, and trends to the future. In addition, a current practice review was performed from a literature review that included a questionnaire of the knowledge and opinion about nanotechnology, which included students, general contractors, teachers, engineers, and architects. The second part will deal with the advancement of the application of nanotechnology in pavement materials for different developed countries. Because nanotechnology is relatively a young field in pavement materials, limited research has been conducted in North America, Europe, and Asia. A comparison of the advancement of nano-science-based principles, as applied to the performance and life cycle of transportation materials, for the three continents will be carried out in a summarized manner.

  4. Solid state laser systems for space application

    NASA Technical Reports Server (NTRS)

    Kay, Richard B.

    1994-01-01

    Since the last report several things have happened to effect the research effort. In laser metrology, measurements using Michelson type interferometers with an FM modulated diode laser source have been performed. The discrete Fourier transform technique has been implemented. Problems associated with this technique as well as the overall FM scheme were identified. The accuracy of the technique is not at the level we would expect at this point. We are now investigating the effect of various types of noise on the accuracy as well as making changes to the system. One problem can be addressed by modifying the original optical layout. Our research effort was also expanded to include the assembly and testing of a diode pumped\\Nd:YAG laser pumped\\Ti sapphire laser for possible use in sounding rocket applications. At this stage, the diode pumped Nd:YAG laser has been assembled and made operational.

  5. Solid state dye laser for medical applications

    NASA Astrophysics Data System (ADS)

    Aldag, Henry R.

    1994-06-01

    The development of solid state dye lasers could lead to a major breakthrough in the cost and compactness of a medical device. Advantages include: elimination of the flow system for the gain medium; ease with which to implement wavelength agility or the replacement of a degraded rod or sheet; and toxicity and flammability become a non-issue. Dye lasers have played a role in cardiology, dermatology, and urology. Of these cardiology is of interest to Palomar. The Palomar Model 3010 flashlamp-pumped dye laser medical device was used during phase 1 FDA clinical trials to break-up blood clots that cause heart attacks, a process known as coronary laser thrombolysis. It is the objective of this research and development effort to produce solid matrix lasers that will replace liquid dye lasers in these medical specialties.

  6. Solid state neutron dosimeter for space applications

    SciTech Connect

    Nagarkar, V.; Entine, G.; Stoppel, P.; Cirignano, L. ); Swinehart, P. )

    1992-08-01

    One of the most important contributions to the radiation exposure of astronauts engaged in space flight is the significant flux of high energy neutrons arising from both primary and secondary sources of ionizing radiation. Under NASA sponsorship, the authors are developing a solid state neutron sensor capable of being incorporated into a very compact, flight instrument to provide high quality real time measurement of this important radiation flux. The dosimeter uses a special, high neutron sensitivity, PIN diode that is insensitive t the other forms of ionizing radiation. The dosimeter will have the ability to measure and record neutron dose over a range of 50 microgray to tens of milligrays (5 millirads to several rads) over a flight of up to 30 days. the performance characteristics of the PIN diode with a detailed description of the overall dosimeter is presented. in this paper.

  7. The Obstacle Version of the Geometric Dynamic Programming Principle: Application to the Pricing of American Options Under Constraints

    SciTech Connect

    Bouchard, Bruno Vu, Thanh Nam

    2010-04-15

    We provide an obstacle version of the Geometric Dynamic Programming Principle of Soner and Touzi (J. Eur. Math. Soc. 4:201-236, 2002) for stochastic target problems. This opens the doors to a wide range of applications, particularly in risk control in finance and insurance, in which a controlled stochastic process has to be maintained in a given set on a time interval [0,T]. As an example of application, we show how it can be used to provide a viscosity characterization of the super-hedging cost of American options under portfolio constraints, without appealing to the standard dual formulation from mathematical finance. In particular, we allow for a degenerate volatility, a case which does not seem to have been studied so far in this context.

  8. Application of similitude principle to the numerical simulation of solar atmospheric dynamics

    NASA Technical Reports Server (NTRS)

    Wu, S. T.; Wang, S.; Wang, A. H.; Dryer, M.

    1988-01-01

    Numerical simulation has become an essential part of solar physics because the complex nonlinear characteristics of solar phenomena makes analytical solutions difficult to obtain. Realistic simulation of the birth and decay of an active region still is not possible because of the wide range of spatial and time scales that must be considered. Therefore, proper scaling rules must be recognized for the development of appropriate models. In this paper, the similitude principle is applied to develop scaling rules. It is found that these rules are highly dependent on the physical nature of the specific problem under consideration. A set of 'similitude critiques' is presented for some specific physical conditions. Numerical examples of coronal dynamic response and active region dynamics are used to demonstrate these ideas.

  9. Application of similitude principle to the numerical simulation of solar atmospheric dynamics

    NASA Astrophysics Data System (ADS)

    Wu, S. T.; Wang, S.; Wang, A. H.; Dryer, M.

    Numerical simulation has become an essential part of solar physics because the complex nonlinear characteristics of solar phenomena makes analytical solutions difficult to obtain. Realistic simulation of the birth and decay of an active region still is not possible because of the wide range of spatial and time scales that must be considered. Therefore, proper scaling rules must be recognized for the development of appropriate models. In this paper, the similitude principle is applied to develop scaling rules. It is found that these rules are highly dependent on the physical nature of the specific problem under consideration. A set of 'similitude critiques' is presented for some specific physical conditions. Numerical examples of coronal dynamic response and active region dynamics are used to demonstrate these ideas.

  10. Application of the low-frequency energy principle to wall modesa)

    NASA Astrophysics Data System (ADS)

    Hu, Bo; Betti, R.; Manickam, J.

    2005-05-01

    The effects of trapped particles on the stability of the n =1 resistive wall mode are investigated by means of a generalized energy principle. The analysis is carried out for the stationary high-β plasma equilibrium of the International Thermonuclear Experimental Reactor (ITER) [ K. Tomabechi Nucl. Fusion 31, 1135 (1991)] advanced-tokamak scenario. It is found that the trapped particle compressibility and the dissipation induced by the mode resonance with the trapped particle precession motion are stabilizing. By retaining the contribution of trapped thermal ions, electrons, and α particles, the resistive wall mode growth rate is significantly reduced and the mode almost fully suppressed. This effect vanishes for fast flowing plasmas rotating toroidally with a frequency above the ion diamagnetic frequency.

  11. Principles and applications of a controllable electromagnetic band gap material to a conformable spherical radome

    NASA Astrophysics Data System (ADS)

    Haché, S.; Burokur, S. N.; de Lustrac, A.; Gadot, F.; Cailleu, P.; Piau, G.-P.

    2009-06-01

    This paper presents the principle of two types of conformable and controllable spherical radome based on Electromagnetic Band Gap (EBG) materials operating at around 10 GHz. The EBG structure is composed of a grid of metallic wires conformed on a hollow spherical object. Two switching control configurations are considered: (1) between an EBG structure made of electrically continuous wires and another one made of discontinuous wires, and (2) between two EBG structures made of discontinuous wires where each has a different period of discontinuities. Both switching configurations are simulated and experimentally characterized on passive prototypes. An excellent agreement is observed between simulations and measurements. The radiation patterns of two types of antennas, a horn antenna and a meteorological antenna, are also measured in the presence of the radome.

  12. Basic principles and applications of fractal geometry in pathology: a review.

    PubMed

    Dey, Pranab

    2005-10-01

    The basic principles and prospects of fractal geometry in pathology are promising. All articles found with a PubMed search with the keywords fractal dimension (FD) and related to pathology were reviewed. All fractal objects have FDs, commonly calculated with box counting. Fractal geometry has been applied to measure the irregularities of nuclear and glandular margins to distinguish malignant lesions from benign ones, to measure the infiltrative margin of a malignant tumor, to assess tumor angiogenesis and to measure the distribution of collagen in tissue. Fractal geometry has also been applied to assess the irregular distribution of chromatin in malignant cells. Biologic model formation is possible with fractal geometry. In the future, fractal geometry may help with the diagnosis, understanding of pathogenesis and management of lesions. It may also provide new insights into disease processes.

  13. Three-Dimensional Printing: Basic Principles and Applications in Medicine and Radiology

    PubMed Central

    Kim, Guk Bae; Lee, Sangwook; Kim, Haekang; Yang, Dong Hyun; Kim, Young-Hak; Kyung, Yoon Soo; Kim, Choung-Soo; Choi, Se Hoon; Kim, Bum Joon; Ha, Hojin; Kwon, Sun U.

    2016-01-01

    The advent of three-dimensional printing (3DP) technology has enabled the creation of a tangible and complex 3D object that goes beyond a simple 3D-shaded visualization on a flat monitor. Since the early 2000s, 3DP machines have been used only in hard tissue applications. Recently developed multi-materials for 3DP have been used extensively for a variety of medical applications, such as personalized surgical planning and guidance, customized implants, biomedical research, and preclinical education. In this review article, we discuss the 3D reconstruction process, touching on medical imaging, and various 3DP systems applicable to medicine. In addition, the 3DP medical applications using multi-materials are introduced, as well as our recent results. PMID:26957903

  14. Three-Dimensional Printing: Basic Principles and Applications in Medicine and Radiology.

    PubMed

    Kim, Guk Bae; Lee, Sangwook; Kim, Haekang; Yang, Dong Hyun; Kim, Young-Hak; Kyung, Yoon Soo; Kim, Choung-Soo; Choi, Se Hoon; Kim, Bum Joon; Ha, Hojin; Kwon, Sun U; Kim, Namkug

    2016-01-01

    The advent of three-dimensional printing (3DP) technology has enabled the creation of a tangible and complex 3D object that goes beyond a simple 3D-shaded visualization on a flat monitor. Since the early 2000s, 3DP machines have been used only in hard tissue applications. Recently developed multi-materials for 3DP have been used extensively for a variety of medical applications, such as personalized surgical planning and guidance, customized implants, biomedical research, and preclinical education. In this review article, we discuss the 3D reconstruction process, touching on medical imaging, and various 3DP systems applicable to medicine. In addition, the 3DP medical applications using multi-materials are introduced, as well as our recent results.

  15. Recent advances of mid-infrared compact, field deployable sensors: principles and applications

    NASA Astrophysics Data System (ADS)

    Tittel, Frank; Gluszek, Aleksander; Hudzikowski, Arkadiusz; Dong, Lei; Li, Chunguang; Patimisco, Pietro; Sampaolo, Angelo; Spagnolo, Vincenzo; Wojtas, Jacek

    2016-04-01

    The recent development of compact interband cascade lasers(ICLs) and quantum cascade lasers (QCLs) based trace gas sensors will permit the targeting of strong fundamental rotational-vibrational transitions in the mid-infrared which are one to two orders of magnitude more intense than transitions in the overtone and combination bands in the near-infrared. This has led to the design and fabrication of mid-infrared compact, field deployable sensors for use in the petrochemical industry, environmental monitoring and atmospheric chemistry. Specifically, the spectroscopic detection and monitoring of four molecular species, methane (CH4) [1], ethane (C2H6), formaldehyde (H2CO) [2] and hydrogen sulphide (H2S) [3] will be described. CH4, C2H6 and H2CO can be detected using two detection techniques: mid-infrared tunable laser absorption spectroscopy (TDLAS) using a compact multi-pass gas cell and quartz enhanced photoacoustic spectroscopy (QEPAS). Both techniques utilize state-of-the-art mid-IR, continuous wave (CW), distributed feedback (DFB) ICLs and QCLs. TDLAS was performed with an ultra-compact 54.6m effective optical path length innovative spherical multipass gas cell capable of 435 passes between two concave mirrors separated by 12.5 cm. QEPAS used a small robust absorption detection module (ADM) which consists of a quartz tuning fork (QTF), two optical windows, gas inlet/outlet ports and a low noise frequency pre-amplifier. Wavelength modulation and second harmonic detection were employed for spectral data processing. TDLAS and QEPAS can achieve minimum detectable absorption losses in the range from 10-8 to 10-11cm-1/Hz1/2. Several recent examples of real world applications of field deployable gas sensors will be described. For example, an ICL based TDLAS sensor system is capable of detecting CH4 and C2H6 concentration levels of 1 ppb in a 1 sec. sampling time, using an ultra-compact, robust sensor architecture. H2S detection was realized with a THz QEPAS sensor

  16. Extrema Principles Of Dissipation In Fluids

    NASA Technical Reports Server (NTRS)

    Horne, W. Clifton; Karamcheti, Krishnamurty

    1991-01-01

    Report discusses application of principle of least action and other variational or extrema principles to dissipation of energy and production of entropy in fluids. Principle of least action applied successfully to dynamics of particles and to quantum mechanics, but not universally accepted that variational principles applicable to thermodynamics and hydrodynamics. Report argues for applicability of some extrema principles to some simple flows.

  17. Dual-energy CT revisited with multidetector CT: review of principles and clinical applications.

    PubMed

    Karçaaltıncaba, Muşturay; Aktaş, Aykut

    2011-09-01

    Although dual-energy CT (DECT) was first conceived in the 1970s, it was not widely used for CT indications. Recently, the simultaneous acquisition of volumetric dual-energy data has been introduced using multidetector CT (MDCT) with two X-ray tubes and rapid kVp switching (gemstone spectral imaging). Two major advantages of DECT are material decomposition by acquiring two image series with different kVp and the elimination of misregistration artifacts. Hounsfield unit measurements by DECT are not absolute and can change depending on the kVp used for an acquisition. Typically, a combination of 80/140 kVp is used for DECT, but for some applications, 100/140 kVp is preferred. In this study, we summarized the clinical applications of DECT and included images that were acquired using the dual-source CT and rapid kVp switching. In general, unenhanced images can be avoided by using DECT for body and neurological applications; iodine can be removed from the image, and a virtual, non-contrast (water) image can be obtained. Neuroradiological applications allow for the removal of bone and calcium from the carotid and brain CT angiography. Thorax applications include perfusion imaging in patients with pulmonary thromboemboli and other chest diseases, xenon ventilation-perfusion imaging and solitary nodule characterization. Cardiac applications include dual-energy cardiac perfusion, viability and cardiac iron detection. The removal of calcific plaques from arteries, bone removal and aortic stent graft evaluation may be achieved in the vascular system. Abdominal applications include the detection and characterization of liver and pancreas masses, the diagnosis of steatosis and iron overload, DECT colonoscopy and CT cholangiography. Urinary system applications are urinary calculi characterization (uric acid vs. non-uric acid), renal cyst characterization and mass characterization. Musculoskeletal applications permit the differentiation of gout from pseudogout and a reduction of

  18. Combining (27)Al Solid-State NMR and First-Principles Simulations To Explore Crystal Structure in Disordered Aluminum Oxynitride.

    PubMed

    Tu, Bingtian; Liu, Xin; Wang, Hao; Wang, Weimin; Zhai, Pengcheng; Fu, Zhengyi

    2016-12-19

    The nuclear magnetic resonance (NMR) technique gives insight into the local information in a crystal structure, while Rietveld refinement of powder X-ray diffraction (PXRD) sketches out the framework of a crystal lattice. In this work, first-principles calculations were combined with the solid-state NMR technique and Rietveld refinement to explore the crystal structure of a disordered aluminum oxynitride (γ-alon). The theoretical NMR parameters (chemical shift, δiso, quadrupolar coupling constants, CQ, and asymmetry parameter, η) of Al22.5O28.5N3.5, predicted by the gauge-including projector augmented wave (GIPAW) algorithm, were used to facilitate the analytical investigation of the (27)Al magic-angle spinning (MAS) NMR spectra of the as-prepared sample, whose formula was confirmed to be Al2.811O3.565N0.435 by quantitative analysis. The experimental δiso, CQ, and η of (27)Al showed a small discrepancy compared with theoretical models. The ratio of aluminum located at the 8a to 16d sites was calculated to be 0.531 from the relative integration of peaks in the (27)Al NMR spectra. The occupancies of aluminum at the 8a and 16d positions were determined through NMR investigations to be 0.9755 and 0.9178, respectively, and were used in the Rietveld refinement to obtain the lattice parameter and anion parameter of Al2.811O3.565N0.435. The results from (27)Al NMR investigations and PXRD structural refinement complemented each other. This work provides a powerful and accessible strategy to precisely understand the crystal structure of novel oxynitride materials with multiple disorder.

  19. Defect states at organic-inorganic interfaces: Insight from first principles calculations for pentaerythritol tetranitrate on MgO surface

    NASA Astrophysics Data System (ADS)

    Tsyshevsky, Roman V.; Rashkeev, Sergey N.; Kuklja, Maija M.

    2015-07-01

    Light-responsive organic-inorganic interfaces offer experimental opportunities that are otherwise difficult to achieve. Since laser light can be manipulated very precisely, it becomes possible to engineer selective, predictive, and highly controlled interface properties. Photochemistry of organic-inorganic energetic interfaces is a rapidly emerging research field in which energy absorption and interface stability mechanisms have yet to be established. To explore the interaction of the laser irradiation with molecular materials, we performed first principle calculations of a prototype organic-inorganic interface between a nitroester (pentaerythritol tetranitrate, PETN, C5H8N4O12) and a magnesium oxide (MgO) surface. We found that the light absorption is defined by the band alignment between interface components and interfacial charge transfer coupled with electronic states in the band gap, generated by oxide surface defects. Hence the choice of an oxide substrate and its morphology makes the optical absorption tunable and governs both the energy accumulation and energy release at the interface. The obtained results offer a possible consistent interpretation of experiments on selective laser initiation of energetic materials, which reported that the presence of metal oxide additives triggered the photoinitiation by excitation energy much lower than the band gap. We suggest that PETN photodecomposition is catalyzed by oxygen vacancies (F0 centers) at the MgO surface. Our conclusions predict ways for a complete separation of thermo- and photo-stimulated interface chemistry of molecular materials, which is imperative for highly controllable fast decomposition and was not attainable before. The methodology described here can be applied to any type of molecular material/wide band gap dielectric interfaces. It provides a solid basis for novel design and targeted improvements of organic-inorganic interfaces with desired properties that promise to enable vastly new concepts

  20. Large Deviations for Finite State Markov Jump Processes with Mean-Field Interaction Via the Comparison Principle for an Associated Hamilton-Jacobi Equation

    NASA Astrophysics Data System (ADS)

    Kraaij, Richard

    2016-07-01

    We prove the large deviation principle (LDP) for the trajectory of a broad class of finite state mean-field interacting Markov jump processes via a general analytic approach based on viscosity solutions. Examples include generalized Ehrenfest models as well as Curie-Weiss spin flip dynamics with singular jump rates. The main step in the proof of the LDP, which is of independent interest, is the proof of the comparison principle for an associated collection of Hamilton-Jacobi equations. Additionally, we show that the LDP provides a general method to identify a Lyapunov function for the associated McKean-Vlasov equation.

  1. First principles based multiscale modeling of single crystal plasticity: Application to BCC tantalum

    NASA Astrophysics Data System (ADS)

    Wang, Guofeng

    We developed and exercised a first principles based multiscale approach to model plastic behaviors of high-purity Tantalum (Ta) single crystals. Our approach consists of three hierarchical parts. (1) Derive the atomistic interaction potential for Ta based on the data obtained from the accurate quantum mechanics (QM) calculation. (2) Predict the properties and behaviors of dislocations in the atomistic simulations using the derived first principles potential. (3) Describe the material plasticity in the kink pair mechanism based mesoscopic model with the input of the predicted atomistic level dislocation properties. In this thesis work, we accurately determined the core structure, core energy, Peierls energy barriers, Peierls stresses, kink formation energy, kink migration energy, and kink structures for 1/2a<111> screw dislocations in bcc Ta using molecular dynamics (MD) simulations. The major results are as follows. (1) The core energy is 1.400 eV/b for the asymmetric screw dislocation cores, which spread out along three <112> directions in the {110} planes. (2) The dislocation core is formed by the 12 atoms with higher strain energies around the dislocation center. (3) The twinning and anti-twinning asymmetry of shears is the main cause for the non-Schmid behavior of screw dislocations in bcc metals. (4) For 1/2a<111> screw dislocations in Ta, the Peierls energy barrier is 0.032 eV/b under twinning shears and 0.068 eV/b under anti-twinning shears. The Peierls stress is 790 MPa under twinning shears and 1430 MPa under anti-twinning shears. (5) The minimal energy cost to form a kink pair along the dislocation is 0.794 eV. (6) The effective kink pair nucleation length is 16 b. (7) There are two kinds of elementary kinks and six kinds of composite kinks. We further input these atomistic simulation results to a mesoscopic plasticity model [A. M. Cuitino, L. Stainer and M. Ortiz, Journal of the Mechanics and Physics of Solids, 2001]. The resulting atomistically informed

  2. Principles and application of high pressure-based technologies in the food industry.

    PubMed

    Balasubramaniam, V M Bala; Martínez-Monteagudo, Sergio I; Gupta, Rockendra

    2015-01-01

    High pressure processing (HPP) has emerged as a commercially viable food manufacturing tool that satisfies consumers' demand for mildly processed, convenient, fresh-tasting foods with minimal to no preservatives. Pressure treatment, with or without heat, inactivates pathogenic and spoilage bacteria, yeast, mold, viruses, and also spores and extends shelf life. Pressure treatment at ambient or chilled temperatures has minimal impact on product chemistry. The product quality and shelf life are often influenced more by storage conditions and packaging material barrier properties than the treatment itself. Application of pressure reduces the thermal exposure of the food during processing, thereby protecting a variety of bioactive compounds. This review discusses recent scientific advances of high pressure technology for food processing and preservation applications such as pasteurization, sterilization, blanching, freezing, and thawing. We highlight the importance of in situ engineering and thermodynamic properties of food and packaging materials in process design. Current and potential future promising applications of pressure technology are summarized.

  3. High-speed holographic metrology: principle, limitations, and application to vibroacoustics of structures

    NASA Astrophysics Data System (ADS)

    Poittevin, Julien; Gautier, François; Pézerat, Charles; Picart, Pascal

    2016-12-01

    This paper describes the basics of high-speed holographic metrology, its limitations, and its application to the investigation of traveling acoustic waves propagating in mechanical structures. Limits are related to a few parameters that must be carefully adjusted for the recording. A full numerical simulation of the recording-reconstruction holographic process is presented and used to investigate the decorrelation phase noise induced by spatial resolution, active surface of pixels, and short exposure time. Applications to vibroacoustics of structures consider the case of waves propagating after a shock by impact hammer and wave interaction in one-dimensional and two-dimensional acoustic black hole extremities.

  4. Directed Alternative Splicing in Nijmegen Breakage Syndrome: Proof of Principle Concerning Its Therapeutical Application

    PubMed Central

    Salewsky, Bastian; Hildebrand, Gabriele; Rothe, Susanne; Parplys, Ann Christin; Radszewski, Janina; Kieslich, Moritz; Wessendorf, Petra; Krenzlin, Harald; Borgmann, Kerstin; Nussenzweig, André; Sperling, Karl; Digweed, Martin

    2016-01-01

    Over 90% of patients with Nijmegen breakage syndrome (NBS), a hereditary cancer disorder, are homoallelic for a 5 bp deletion in the NBN gene involved in the cellular response to DNA damage. This hypomorphic mutation leads to a carboxy-terminal protein fragment, p70-nibrin, with some residual function. Average age at malignancy, typically lymphoma, is 9.7 years. NBS patients are hypersensitive to chemotherapeutic and radiotherapeutic treatments, thus prevention of cancer development is of particular importance. Expression of an internally deleted NBN protein, p80-nibrin, has been previously shown to be associated with a milder cellular phenotype and absence of cancer in a 62-year-old NBS patient. Here we show that cells from this patient, unlike other NBS patients, have DNA replication and origin firing rates comparable to control cells. We used here antisense oligonucleotides to enforce alternative splicing in NBS patient cells and efficiently generate the same internally deleted p80-nibrin protein. Injecting the same antisense sequences as morpholino oligomers (VivoMorpholinos) into the tail vein of a humanized NBS murine mouse model also led to efficient alternative splicing in vivo. Thus, proof of principle for the use of antisense oligonucleotides as a potential cancer prophylaxis has been demonstrated. PMID:26265251

  5. Developing an approach for first-principles catalyst design: application to carbon-capture catalysis.

    PubMed

    Kulik, Heather J; Wong, Sergio E; Baker, Sarah E; Valdez, Carlos A; Satcher, Joe H; Aines, Roger D; Lightstone, Felice C

    2014-02-01

    An approach to catalyst design is presented in which local potential energy surface models are first built to elucidate design principles and then used to identify larger scaffold motifs that match the target geometries. Carbon sequestration via hydration is used as the model reaction, and three- and four-coordinate sp(2) or sp(3) nitrogen-ligand motifs are considered for Zn(II) metals. The comparison of binding, activation and product release energies over a large range of interaction distances and angles suggests that four-coordinate short Zn(II)-Nsp(3) bond distances favor a rapid turnover for CO2 hydration. This design strategy is then confirmed by computationally characterizing the reactivity of a known mimic over a range of metal-nitrogen bond lengths. A search of existing catalysts in a chemical database reveals structures that match the target geometry from model calculations, and subsequent calculations have identified these structures as potentially effective for CO2 hydration and sequestration.

  6. First-principles investigations on ionization and thermal conductivity of polystyrene for inertial confinement fusion applications

    DOE PAGES

    Hu, S. X.; Collins, L. A.; Goncharov, V. N.; ...

    2016-04-14

    Using quantum molecular-dynamics (QMD) methods based on the density functional theory, we have performed first-principles investigations on the ionization and thermal conductivity of polystyrene (CH) over a wide range of plasma conditions (ρ = 0.5 to 100 g/cm3 and T = 15,625 to 500,000 K). The ionization data from orbital-free molecular-dynamics calculations have been fitted with a “Saha-type” model as a function of the CH plasma density and temperature, which exhibits the correct behaviors of continuum lowering and pressure ionization. The thermal conductivities (κQMD) of CH, derived directly from the Kohn–Sham molecular-dynamics calculations, are then analytically fitted with a generalizedmore » Coulomb logarithm [(lnΛ)QMD] over a wide range of plasma conditions. When compared with the traditional ionization and thermal conductivity models used in radiation–hydrodynamics codes for inertial confinement fusion simulations, the QMD results show a large difference in the low-temperature regime in which strong coupling and electron degeneracy play an essential role in determining plasma properties. Furthermore, hydrodynamic simulations of cryogenic deuterium–tritium targets with CH ablators on OMEGA and the National Ignition Facility using the QMD-derived ionization and thermal conductivity of CH have predicted –20% variation in target performance in terms of hot-spot pressure and neutron yield (gain) with respect to traditional model simulations.« less

  7. First-principles investigations on ionization and thermal conductivity of polystyrene for inertial confinement fusion applications

    SciTech Connect

    Hu, S. X.; Collins, L. A.; Goncharov, V. N.; Kress, J. D.; McCrory, R. L.; Skupsky, S.

    2016-04-14

    Using quantum molecular-dynamics (QMD) methods based on the density functional theory, we have performed first-principles investigations on the ionization and thermal conductivity of polystyrene (CH) over a wide range of plasma conditions (ρ = 0.5 to 100 g/cm3 and T = 15,625 to 500,000 K). The ionization data from orbital-free molecular-dynamics calculations have been fitted with a “Saha-type” model as a function of the CH plasma density and temperature, which exhibits the correct behaviors of continuum lowering and pressure ionization. The thermal conductivities (κQMD) of CH, derived directly from the Kohn–Sham molecular-dynamics calculations, are then analytically fitted with a generalized Coulomb logarithm [(lnΛ)QMD] over a wide range of plasma conditions. When compared with the traditional ionization and thermal conductivity models used in radiation–hydrodynamics codes for inertial confinement fusion simulations, the QMD results show a large difference in the low-temperature regime in which strong coupling and electron degeneracy play an essential role in determining plasma properties. Furthermore, hydrodynamic simulations of cryogenic deuterium–tritium targets with CH ablators on OMEGA and the National Ignition Facility using the QMD-derived ionization and thermal conductivity of CH have predicted –20% variation in target performance in terms of hot-spot pressure and neutron yield (gain) with respect to traditional model simulations.

  8. Application of first principle nickel system battery models to aerospace situations

    SciTech Connect

    Stefano, S. Di; Timmerman, P.; Ratnakumar, B.V.

    1995-12-31

    Battery models based on first principles have been under development for the last five to ten years. More recently, the appearance of faster and more sophisticated computational techniques, has allowed significant advances in the field. The usual approach consists of selecting the critical physicochemical phenomena of the given system (chemistry, mass transfer, charge transfer, etc.), setting up the problem as a set of coupled differential equations and obtaining numerical solutions. This approach was successfully implemented for the Pb-Acid system and subsequently for the NiCd system, at the cell level, by Prof. Ralph White of Texas A and M University. This NiCd cell model served as the basis of the NiCd Aerospace Battery model developed at JPL and reported at previous IECEC meetings. At this time several aerospace battery models using the same approach are under development at JPL. The recent models are based on NiH2 and NiMH chemistries. The current set of models uses a simplified treatment of the electrodes, this treatment assumes planar (non porous) electrode geometry. The resulting models have very modest computational requirements, allowing them to operate on personal computers. Results of performance predictions and computational requirements for the new models are discussed.

  9. 3D nanostructure reconstruction based on the SEM imaging principle, and applications.

    PubMed

    Zhu, Fu-Yun; Wang, Qi-Qi; Zhang, Xiao-Sheng; Hu, Wei; Zhao, Xin; Zhang, Hai-Xia

    2014-05-09

    This paper addresses a novel 3D reconstruction method for nanostructures based on the scanning electron microscopy (SEM) imaging principle. In this method, the shape from shading (SFS) technique is employed, to analyze the gray-scale information of a single top-view SEM image which contains all the visible surface information, and finally to reconstruct the 3D surface morphology. It offers not only unobstructed observation from various angles but also the exact physical dimensions of nanostructures. A convenient and commercially available tool (NanoViewer) is developed based on this method for nanostructure analysis and characterization of properties. The reconstruction result coincides well with the SEM nanostructure image and is verified in different ways. With the extracted structure information, subsequent research of the nanostructure can be carried out, such as roughness analysis, optimizing properties by structure improvement and performance simulation with a reconstruction model. Efficient, practical and non-destructive, the method will become a powerful tool for nanostructure surface observation and characterization.

  10. Anharmonic force constants extracted from first-principles molecular dynamics: applications to heat transfer simulations.

    PubMed

    Tadano, T; Gohda, Y; Tsuneyuki, S

    2014-06-04

    A systematic method to calculate anharmonic force constants of crystals is presented. The method employs the direct-method approach, where anharmonic force constants are extracted from the trajectory of first-principles molecular dynamics simulations at high temperature. The method is applied to Si where accurate cubic and quartic force constants are obtained. We observe that higher-order correction is crucial to obtain accurate force constants from the trajectory with large atomic displacements. The calculated harmonic and anharmonic force constants are, then, combined with the Boltzmann transport equation (BTE) and non-equilibrium molecular dynamics (NEMD) methods in calculating the thermal conductivity. The BTE approach successfully predicts the lattice thermal conductivity of bulk Si, whereas NEMD shows considerable underestimates. To evaluate the linear extrapolation method employed in NEMD to estimate bulk values, we analyze the size dependence in NEMD based on BTE calculations. We observe strong nonlinearity in the size dependence of NEMD in Si, which can be ascribed to acoustic phonons having long mean-free-paths and carrying considerable heat. Subsequently, we also apply the whole method to a thermoelectric material Mg2Si and demonstrate the reliability of the NEMD method for systems with low thermal conductivities.

  11. Application of a principle of synchronicity to an analysis of climatic processes

    NASA Astrophysics Data System (ADS)

    Tartakovsky, V. A.; Krutikov, V. A.; Volkov, Y. V.; Cheredko, N. N.

    2016-11-01

    Geospheric processes are largely initiated and controlled by external influences. The Sun is the main source of energy, and it contributes to those processes directly and as a regulator of some cosmic influences. The forcing effects synchronize the oscillatory processes in the solar system. Specific processes differ in energy. However, they show similar essential signs. Components, which differ in coincidence and non-coincidence of the essential signs, are introduced. Based on a synchronous analysis of the monthly averaged Wolf numbers series and temperatures registered at 818 weather stations in the Northern Hemisphere (1955-2010), we show that the above-introduced components of the series under consideration have extreme properties. The histograms of the primary temperature series coincide with those of their components, except for a range of ± 3°C. The second initial moments of the Wolf numbers correspond to the climate geography and can be divided into two zones, the width and the distance between them are about one third of all possible changes. A synchronicity principle allows performing a decomposition of the original set into subsets containing strongly related elements. The relationship between the synchronization features of geospheric processes initiated by external forcing and the physical and geographical hierarchy allows solving some problems of classification. Some experimental results for the temperature field are presented. The approach has revealed some new properties of the solar-terrestrial relations. No inconsistencies with the known notions of climatic processes have been found.

  12. Qualitative Research in Emergency Care Part I: Research Principles and Common Applications.

    PubMed

    Choo, Esther K; Garro, Aris C; Ranney, Megan L; Meisel, Zachary F; Morrow Guthrie, Kate

    2015-09-01

    Qualitative methods are increasingly being used in emergency care research. Rigorous qualitative methods can play a critical role in advancing the emergency care research agenda by allowing investigators to generate hypotheses, gain an in-depth understanding of health problems or specific populations, create expert consensus, and develop new intervention and dissemination strategies. This article, Part I of a two-article series, provides an introduction to general principles of applied qualitative health research and examples of its common use in emergency care research, describing study designs and data collection methods most relevant to our field, including observation, individual interviews, and focus groups. In Part II of this series, we will outline the specific steps necessary to conduct a valid and reliable qualitative research project, with a focus on interview-based studies. These elements include building the research team, preparing data collection guides, defining and obtaining an adequate sample, collecting and organizing qualitative data, and coding and analyzing the data. We also discuss potential ethical considerations unique to qualitative research as it relates to emergency care research.

  13. First-principles nonequilibrium Green's-function approach to transient photoabsorption: Application to atoms

    NASA Astrophysics Data System (ADS)

    Perfetto, E.; Uimonen, A.-M.; van Leeuwen, R.; Stefanucci, G.

    2015-09-01

    We put forward a first-principle nonequilibrium Green's-function (NEGF) approach to calculate the transient photoabsorption spectrum of optically thin systems. The method can deal with pump fields of arbitrary strength, frequency, and duration as well as overlapping and nonoverlapping pump and probe pulses. The electron-electron repulsion is accounted for by the correlation self-energy, and the resulting numerical scheme deals with matrices that scale quadratically with the system size. Two recent experiments, the first on helium and the second on krypton, are addressed. For the first experiment we explain the bending of the Autler-Townes absorption peaks with increasing pump-probe delay τ and relate the bending to the thickness and density of the gas. For the second experiment we find that sizable spectral structures of the pump-generated admixture of Kr ions are fingerprints of dynamical correlation effects, and hence they cannot be reproduced by time-local self-energy approximations. Remarkably, the NEGF approach also captures the retardation of the absorption onset of Kr2 + with respect to Kr1 + as a function of τ .

  14. Three-dimensional sonoelastography: Principles and practices with application to tumor visualization and volume estimation

    NASA Astrophysics Data System (ADS)

    Taylor, Lawrence Steven

    Sonoelastography is an ultrasound imaging technique first proposed by Parker and Lerner at the University of Rochester in the 1980's. In this modality low amplitude, low frequency shear waves (less than 0.1 mm displacement and less than 1 KHz frequency) are propagated deep into tissue, while real time Doppler techniques are used to image the resulting vibration pattern. When a discrete hard inhomogeneity, such as a tumor, is present within a region of soft tissue, a decrease in the vibration amplitude will occur at its location. This forms the basis for tumor detection using sonoelastography. The acquisition of a commercial scanner modified to do vibration Doppler imaging provided the opportunity to implement sonoelastography as a real-time imaging system. Sonoelastography is applied to the imaging of hard lesions in ultrasound phantoms, thermal necrosis lesions induced in liver tissue and in-vitro prostate cancer detection. A lesion model using the injection of formaldehyde in liver tissue is developed and explored. Sonoelastography and magnetic resonance images of a tissue phantom containing a hard isoechoic inclusion are compared to evaluate the accuracy of this method. The principles behind this imaging modality are explained and the practical aspects of acquiring sonoelastography images are described. Results are shown from three-dimensional sonoelastography reconstruction of ex-vivo whole prostate specimens containing prostate cancer.

  15. Goldstone-like states in a layered perovskite with frustrated polarization: a first-principles investigation of PbSr2Ti2O7.

    PubMed

    Nakhmanson, S M; Naumov, Ivan

    2010-03-05

    With the help of first-principles-based computational techniques, we demonstrate that Goldstone-like states can be artificially induced in a layered-perovskite ferroelectric compound with frustrated polarization, resulting in the emergence of a variety of interesting physical properties that include large, tunable dielectric constants and an ability to easily form vortex polar states in a nanodot geometry. In a similar fashion to the well-known perovskite materials with morphotropic phase boundaries (MPBs), these states manifest themselves as polarization rotations with almost no energy penalty, suggesting that the existence of an MPB is actually yet another manifestation of the Goldstone theorem in solids.

  16. Application of Cognitive Science Principles: Instructional Heuristics and Mechanisms for Use.

    ERIC Educational Resources Information Center

    Montague, William E.

    Cognitive science is briefly reviewed, and its implications for instructional design are discussed. The application of cognitive science to instruction requires knowledge of cognitive science, the subject content taught, and the system in which the instruction is imbedded. The central concept of cognitive science is mental representation--the…

  17. Universal Design for Learning in Postsecondary Education: Reflections on Principles and their Application

    ERIC Educational Resources Information Center

    Rose, David H.; Harbour, Wendy S.; Johnston, Catherine Sam; Daley, Samantha G.; Abarbanell, Linda

    2006-01-01

    Authored by the teaching staff of T-560: Meeting the Challenge of Individual Differences at the Harvard Graduate School of Education, this article reflects on potential applications of universal design for learning (UDL) in university courses, illustrating major points with examples from T-560. The article explains the roots of UDL in cognitive…

  18. Theoretical Application of Irreversible (Nonequilibrium) Thermodynamic Principles to Enhance Solute Fluxes across Nanofabricated Hemodialysis Membranes

    PubMed Central

    Hedayat, Assem; Elmoselhi, Hamdi; Shoker, Ahmed

    2012-01-01

    Objective. Nanotechnology has the potential to improve hemodialysis membrane technology. Thus, a major objective is to understand how to enhance toxic solute fluxes across these membranes. The aim of this concept building study is to review the application of irreversible thermodynamic (IT) to solute fluxes. Methods. We expanded the application of the Nernst-Planck equation to include the Kedem-Katchalsky equation, pH, membrane thickness, pore size, and electric potential as variables. Results. (1) Reducing the membrane's thickness from 25 μm to 25 nm increased the flux of creatinine, β2-microglobulin, and tumor necrosis factor-α (TNF-α) by a thousand times but prevented completely albumin flux, (2) applying an electric potential of 50–400 mV across the membrane enhanced the flux of the respective molecules by 71.167 × 10−3, 38.7905 × 10−8, and 0.595 × 10−13 mol/s, and (3) changing the pH from 7.35 to 7.42 altered the fluxes minimally. Conclusions. The results supported an argument to investigate the application of IT to study forces of fluxes across membranes. Reducing the membrane's thickness—together with the application of an electrical potential—qualities achievable by nanotechnology, can enhance the removal of uremic toxins by many folds. However, changing the pH at a specific membrane thickness does not affect the flux significantly. PMID:23209903

  19. Two Essays on Learning Disabilities in the Application of Fundamental Financial Principles

    ERIC Educational Resources Information Center

    Auciello, Daria Joy

    2010-01-01

    This dissertation consists of two essays which examine the relationship between dyslexia and the application and acquisition of financial knowledge. Recent behavioral research has documented that factors such as representativeness, overconfidence, loss aversion, naivete, wealth, age and gender all impact a person's risk perception and asset…

  20. 12 CFR 745.2 - General principles applicable in determining insurance of accounts.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... part. The appendix provides examples of the application of these rules to various factual situations... are deposited and on which a claim for insurance coverage is founded. Examples would be trustee, agent... signature card executed by the trustee. (4) The interests of the co-owners of a joint account shall...

  1. Principles and Application of Geographic Information Systems and Internet/Intranet Technology

    DTIC Science & Technology

    2001-04-01

    technology enables the introduction of GIS based services which can be used in Intranets and in the Internet. For these services recently also eCommerce ...114 Figure 5: GIS and Internet example of USGS (screenshot) Some of these application are using eCommerce techniques and products to allow for a more

  2. Frequency-localization Duhamel principle and its application to the optimal decay of dissipative systems in low dimensions

    NASA Astrophysics Data System (ADS)

    Xu, Jiang; Kawashima, Shuichi

    2016-09-01

    Recently, a time-decay framework L2 (Rn) ∩ B˙2, ∞ - s (Rn) (s > 0) has been given by [49] for linearized dissipative hyperbolic systems, which allows to pay less attention to the traditional spectral analysis. However, owing to interpolation techniques, those decay results for nonlinear hyperbolic systems hold true only in higher dimensions (n ≥ 3), and the analysis in low dimensions (say, n = 1 , 2) was left open. We try to give a satisfactory answer in the current work. First of all, we develop new time-decay properties on the frequency-localization Duhamel principle, and then it is shown that the classical solution and its derivatives of fractional order decay at the optimal algebraic rate in dimensions n = 1 , 2, by using a new technique which is the so-called ;piecewise Duhamel principle; in localized time-weighted energy approaches compared to [49]. Finally, as direct applications, explicit decay statements are worked out for some relevant examples subjected to the same dissipative structure, for instance, damped compressible Euler equations, the thermoelasticity with second sound, and Timoshenko systems with equal wave speeds.

  3. Bernoulli's Principle

    ERIC Educational Resources Information Center

    Hewitt, Paul G.

    2004-01-01

    Some teachers have difficulty understanding Bernoulli's principle particularly when the principle is applied to the aerodynamic lift. Some teachers favor using Newton's laws instead of Bernoulli's principle to explain the physics behind lift. Some also consider Bernoulli's principle too difficult to explain to students and avoid teaching it…

  4. Application of bioreactor design principles and multivariate analysis for development of cell culture scale down models.

    PubMed

    Tescione, Lia; Lambropoulos, James; Paranandi, Madhava Ram; Makagiansar, Helena; Ryll, Thomas

    2015-01-01

    A bench scale cell culture model representative of manufacturing scale (2,000 L) was developed based on oxygen mass transfer principles, for a CHO-based process producing a recombinant human protein. Cell culture performance differences across scales are characterized most often by sub-optimal performance in manufacturing scale bioreactors. By contrast in this study, reduced growth rates were observed at bench scale during the initial model development. Bioreactor models based on power per unit volume (P/V), volumetric mass transfer coefficient (kL a), and oxygen transfer rate (OTR) were evaluated to address this scale performance difference. Lower viable cell densities observed for the P/V model were attributed to higher sparge rates and reduced oxygen mass transfer efficiency (kL a) of the small scale hole spargers. Increasing the sparger kL a by decreasing the pore size resulted in a further decrease in growth at bench scale. Due to sensitivity of the cell line to gas sparge rate and bubble size that was revealed by the P/V and kL a models, an OTR model based on oxygen enrichment and increased P/V was selected that generated endpoint sparge rates representative of 2,000 L scale. This final bench scale model generated similar growth rates as manufacturing. In order to take into account other routinely monitored process parameters besides growth, a multivariate statistical approach was applied to demonstrate validity of the small scale model. After the model was selected based on univariate and multivariate analysis, product quality was generated and verified to fall within the 95% confidence limit of the multivariate model.

  5. The principles of ultrasound and its application in freezing related processes of food materials: A review.

    PubMed

    Cheng, Xinfeng; Zhang, Min; Xu, Baoguo; Adhikari, Benu; Sun, Jincai

    2015-11-01

    Ultrasonic processing is a novel and promising technology in food industry. The propagation of ultrasound in a medium generates various physical and chemical effects and these effects have been harnessed to improve the efficiency of various food processing operations. Ultrasound has also been used in food quality control as diagnostic technology. This article provides an overview of recent developments related to the application of ultrasound in low temperature and closely related processes such as freezing, thawing, freeze concentration and freeze drying. The applications of high intensity ultrasound to improve the efficiency of freezing process, to control the size and size distribution of ice crystals and to improve the quality of frozen foods have been discussed in considerable detail. The use of low intensity ultrasound in monitoring the ice content and to monitor the progress of freezing process has also been highlighted.

  6. Applications of molecular Rydberg states in chemical dynamics and spectroscopy

    NASA Astrophysics Data System (ADS)

    Softley, T. P.

    Molecules in high Rydberg states, in which one electron has been excited into a hydrogenic orbital of large mean radius, have many unusual properties compared to ground state molecules. These properties, which are reviewed in this article, make them suitable for a diverse and growing number of applications in chemical dynamics. The most recent methods for studying molecular Rydberg states using high-resolution spectroscopy and theory, including effects of electric fields, are described here. An important feature is the high susceptibility of Rydberg states to external field perturbation which not only has a profound effect on the observable energy levels, spectroscopic intensities and lifetimes, but is also useful for state-selective detection through field ionization. The large dipole moment that can be created in a field is also useful for controlling the motion of molecules in Rydberg states. The applications reviewed here include: ZEKE (zero kinetic energy), MATI (mass-analyzed threshold ionization) and PIRI (photo-induced Rydberg ionization) spectroscopy; pulsed-field recombination of ions and electrons; the state selection and reaction of molecular ions; collisions of Rydberg states with neutrals, ions and metallic surfaces; Rydberg tagging and imaging of products of photodissociation; and the control of translational motion and orientation via the use of inhomogeneous fields.

  7. Common law and a duty of care: the application of principles.

    PubMed

    Fullbrook, Suzanne

    In this series, the author has bought two themes to the reader: first, an awareness of the elements of the common law that operate to inform us of our duties as health providers, and second, current information that is applicable in each of the areas of law that has been discussed. This conclusion is designed to bring together strands of debate that the series has brought to the attention of the reader.

  8. Application of the Sterility Principle for Tsetse Fly Eradication or Control. Revision.

    DTIC Science & Technology

    1981-08-14

    of appropriate chemical, biological or other techniques. The application of the Sterile Insect Technique (SIT) for eradication from an area...certain conditions, it may be economical to use sterile males to create a biological barrier around a central plot and to augment this with a perimeter...treatment of a residual insecticide outside the biological barrier. A biological barrier could be used if the area was reasonably large; in this

  9. Clinical and Biological Principles of Cold Atmospheric Plasma Application in Skin Cancer.

    PubMed

    Gay-Mimbrera, Jesús; García, Maria Carmen; Isla-Tejera, Beatriz; Rodero-Serrano, Antonio; García-Nieto, Antonio Vélez; Ruano, Juan

    2016-06-01

    Plasma-based electrosurgical devices have long been employed for tissue coagulation, cutting, desiccation, and cauterizing. Despite their clinical benefits, these technologies involve tissue heating and their effects are primarily heat-mediated. Recently, there have been significant developments in cold atmospheric pressure plasma (CAP) science and engineering. New sources of CAP with well-controlled temperatures below 40 °C have been designed, permitting safe plasma application on animal and human bodies. In the last decade, a new innovative field, often referred to as plasma medicine, which combines plasma physics, life science, and clinical medicine has emerged. This field aims to exploit effects of mild plasma by controlling the interactions between plasma components (and other secondary species that can be formed from these components) with specific structural elements and functionalities of living cells. Recent studies showed that CAP can exert beneficial effects when applied selectively in certain pathologies with minimal toxicity to normal tissues. The rapid increase in new investigations and development of various devices for CAP application suggest early adoption of cold plasma as a new tool in the biomedical field. This review explores the latest major achievements in the field, focusing on the biological effects, mechanisms of action, and clinical evidence of CAP applications in areas such as skin disinfection, tissue regeneration, chronic wounds, and cancer treatment. This information may serve as a foundation for the design of future clinical trials to assess the efficacy and safety of CAP as an adjuvant therapy for skin cancer.

  10. Variational principles for dissipative (sub)systems, with applications to the theory of linear dispersion and geometrical optics

    DOE PAGES

    Dodin, I. Y.; Zhmoginov, A. I.; Ruiz, D. E.

    2017-02-24

    Applications of variational methods are typically restricted to conservative systems. Some extensions to dissipative systems have been reported too but require ad hoc techniques such as the artificial doubling of the dynamical variables. We propose a different approach. Here, we show that for a broad class of dissipative systems of practical interest, variational principles can be formulated using constant Lagrange multipliers and Lagrangians nonlocal in time, which allow treating reversible and irreversible dynamics on the same footing. A general variational theory of linear dispersion is formulated as an example. Particularly, we present a variational formulation for linear geometrical optics inmore » a general dissipative medium, which is allowed to be nonstationary, inhomogeneous, anisotropic, and exhibit both temporal and spatial dispersion simultaneously.« less

  11. Variational principles for dissipative (sub)systems, with applications to the theory of linear dispersion and geometrical optics

    NASA Astrophysics Data System (ADS)

    Dodin, I. Y.; Zhmoginov, A. I.; Ruiz, D. E.

    2017-04-01

    Applications of variational methods are typically restricted to conservative systems. Some extensions to dissipative systems have been reported too but require ad hoc techniques such as the artificial doubling of the dynamical variables. Here, a different approach is proposed. We show that, for a broad class of dissipative systems of practical interest, variational principles can be formulated using constant Lagrange multipliers and Lagrangians nonlocal in time, which allow treating reversible and irreversible dynamics on the same footing. A general variational theory of linear dispersion is formulated as an example. In particular, we present a variational formulation for linear geometrical optics in a general dissipative medium, which is allowed to be nonstationary, inhomogeneous, anisotropic, and exhibit both temporal and spatial dispersion simultaneously.

  12. The Application of Solid State Physics Principles to Pyrotechnic Mixture Systems

    DTIC Science & Technology

    1987-06-01

    findings were that: o Rolled dolomite sintered at a temperature 100 to 150 0 C lower than unrolled dolomite of the same particle size; 17 * The reaction...pyrotechnic process differs from ordinary combustion because it does not require ambient air. Once the pyrotechnic is triggered by a small external force, it...Shidlouskiyl and described the scheme shown in Figure 1.2 Tmax ’. € /I -. TEMPERATURE To 1 2 3 4 EXTENT OF REACTION Figure 1. Diagram of Combustion of

  13. How to measure what matters: development and application of guiding principles to select measurement instruments in an epidemiologic study on functioning.

    PubMed

    Fekete, Christine; Boldt, Christine; Post, Marcel; Eriks-Hoogland, Inge; Cieza, Alarcos; Stucki, Gerold

    2011-11-01

    The purpose of this article was to describe and to apply a comprehensive set of guiding principles in the selection of measurement instruments for a longitudinal epidemiologic study focusing on functioning using the International Classification of Functioning, Disability, and Health (ICF) as reference framework. Based on the literature, the ICF linkage rules, and the definition of ICF categories to be measured, the following guiding principles for selecting measurement instruments are defined: redundancy, efficiency, level of detail of information, comparability, feasibility, and truth and discrimination. Examples illustrate that the application of guiding principles allows for a systematic and reasoned process of measurement instrument selection and thus offers a potential solution for the multifaceted challenges that one encounters in the selection of measurement instruments. It is transparently demonstrated how the ICF linkage rules enable researchers to address issues such as efficiency, comparability, and redundancy and how the definition of a set of ICF categories to be measured allows assessing inefficiencies in measurement instruments. Because of the ICF linkage rules and the definition of ICF categories to be measured, new guiding principles for selecting measurement instruments emerge. The main challenges lie in the difficulty to quantify and prioritize the applicability of guiding principles and the fact that they strongly interact. Notably, the prioritization and application of guiding principles must be defined considering the specific characteristics and aims of the specific study.

  14. The principles and application of geoelectrochemical sampling for mineral exploration and environmental testing

    NASA Astrophysics Data System (ADS)

    van Blaricom, Richard

    A study was initiated to determine if electrochemical sampling techniques could be effectively utilized to test for ions associated with a metallic ore body or those associated with environmental monitoring. The basis for this study is the Russian technique "CHIM" an acronym for "Chastichnoe Isvlechenniye Mettalov," meaning "partial extraction of metals". The term, geoelectrochemistry, was coined to more accurately explain the technique of electrochemistry in a geological environment. This dissertation studies the ions in the earth and in varying detail the production, the dispersion, the electric mobility, and the collection and analysis of cations. A multi-discipline study consisting of geophysics, electrochemistry, geology, hydrology, and soil physics was undertaken to gain a better understanding of the concepts involved. The study developed several modifications of existing equations, several new equations to explain the movement of cations in the rocks and soils, and two patents. Laboratory experiments were performed to gain a better understanding of basic principles and to develop new concepts. This resulted in developing "Linear Ion Accelerators" and the concepts of "No Flow Boundaries", and "Ionic Streaming Tubes". The potential for geoelectrochemical sampling was soon determined, and there was room for improvement. The equipment and techniques developed can be used on the surface or in drill holes. A high negative potential voltage is applied as a force to move cations towards a collecting device. A collecting cathode using cation exchange resins along with a plate of titanium for the cathode in the collecting electrode was invented. This is called a "collectrode" (collecting electrode). These collect essentially 100% of the attracted cations. The cation exchange resins along with the collected cations are dried and ashed. The resulting ash is later analyzed using standard ICP techniques. The technique is both repeatable and accurate. The equipment and

  15. First-principles thermal conductivity of warm-dense deuterium plasmas for inertial confinement fusion applications

    NASA Astrophysics Data System (ADS)

    Hu, S. X.; Collins, L. A.; Boehly, T. R.; Kress, J. D.; Goncharov, V. N.; Skupsky, S.

    2014-04-01

    Thermal conductivity (κ) of both the ablator materials and deuterium-tritium (DT) fuel plays an important role in understanding and designing inertial confinement fusion (ICF) implosions. The extensively used Spitzer model for thermal conduction in ideal plasmas breaks down for high-density, low-temperature shells that are compressed by shocks and spherical convergence in imploding targets. A variety of thermal-conductivity models have been proposed for ICF hydrodynamic simulations of such coupled and degenerate plasmas. The accuracy of these κ models for DT plasmas has recently been tested against first-principles calculations using the quantum molecular-dynamics (QMD) method; although mainly for high densities (ρ > 100 g/cm3), large discrepancies in κ have been identified for the peak-compression conditions in ICF. To cover the wide range of density-temperature conditions undergone by ICF imploding fuel shells, we have performed QMD calculations of κ for a variety of deuterium densities of ρ = 1.0 to 673.518 g/cm3, at temperatures varying from T = 5 × 103 K to T = 8 × 106 K. The resulting κQMD of deuterium is fitted with a polynomial function of the coupling and degeneracy parameters Γ and θ, which can then be used in hydrodynamic simulation codes. Compared with the "hybrid" Spitzer-Lee-More model currently adopted in our hydrocode lilac, the hydrosimulations using the fitted κQMD have shown up to ˜20% variations in predicting target performance for different ICF implosions on OMEGA and direct-drive-ignition designs for the National Ignition Facility (NIF). The lower the adiabat of an imploding shell, the more variations in predicting target performance using κQMD. Moreover, the use of κQMD also modifies the shock conditions and the density-temperature profiles of the imploding shell at early implosion stage, which predominantly affects the final target performance. This is in contrast to the previous speculation that κQMD changes mainly the

  16. First-principles thermal conductivity of warm-dense deuterium plasmas for inertial confinement fusion applications.

    PubMed

    Hu, S X; Collins, L A; Boehly, T R; Kress, J D; Goncharov, V N; Skupsky, S

    2014-04-01

    Thermal conductivity (κ) of both the ablator materials and deuterium-tritium (DT) fuel plays an important role in understanding and designing inertial confinement fusion (ICF) implosions. The extensively used Spitzer model for thermal conduction in ideal plasmas breaks down for high-density, low-temperature shells that are compressed by shocks and spherical convergence in imploding targets. A variety of thermal-conductivity models have been proposed for ICF hydrodynamic simulations of such coupled and degenerate plasmas. The accuracy of these κ models for DT plasmas has recently been tested against first-principles calculations using the quantum molecular-dynamics (QMD) method; although mainly for high densities (ρ > 100 g/cm3), large discrepancies in κ have been identified for the peak-compression conditions in ICF. To cover the wide range of density-temperature conditions undergone by ICF imploding fuel shells, we have performed QMD calculations of κ for a variety of deuterium densities of ρ = 1.0 to 673.518 g/cm3, at temperatures varying from T = 5 × 103 K to T = 8 × 106 K. The resulting κQMD of deuterium is fitted with a polynomial function of the coupling and degeneracy parameters Γ and θ, which can then be used in hydrodynamic simulation codes. Compared with the "hybrid" Spitzer-Lee-More model currently adopted in our hydrocode lilac, the hydrosimulations using the fitted κQMD have shown up to ∼20% variations in predicting target performance for different ICF implosions on OMEGA and direct-drive-ignition designs for the National Ignition Facility (NIF). The lower the adiabat of an imploding shell, the more variations in predicting target performance using κQMD. Moreover, the use of κQMD also modifies the shock conditions and the density-temperature profiles of the imploding shell at early implosion stage, which predominantly affects the final target performance. This is in contrast to the previous speculation that κQMD changes mainly the

  17. Aquantitative assessment of stochastic electrodynamics with spin (SEDS): Physical principles and novel applications

    NASA Astrophysics Data System (ADS)

    Cavalleri, Giancarlo; Barbero, Francesco; Bertazzi, Gianfranco; Cesaroni, Eros; Tonni, Ernesto; Bosi, Leonardo; Spavieri, Gianfranco; Gillies, George T.

    2010-03-01

    Stochastic electrodynamics (SED) without spin, denoted as pure SED, has been discussed and seriously considered in the literature for several decades because it accounts for important aspects of quantum mechanics (QM). SED is based on the introduction of the nonrenormalized, electromagnetic stochastic zero-point field (ZPF), but neglects the Lorentz force due to the radiation random magnetic field Br. In addition to that rather basic limitation, other drawbacks remain, as well: i) SED fails when there are nonlinear forces; ii) it is not possible to derive the Schrödinger equation in general; iii) it predicts broad spectra for rarefied gases instead of the observed narrow spectral lines; iv) it does not explain double-slit electron diffraction patterns. We show in this short review that all of those drawbacks, and mainly the first most basic one, can be overcome in principle by introducing spin into stochastic electrodynamics (SEDS). Moreover, this modification of the theory also explains four observed effects that are otherwise so far unexplainable by QED, i.e., 1) the physical origin of the ZPF, and its natural upper cutoff; 2) an anomaly in experimental studies of the neutrino rest mass; 3) the origin and quantitative treatment of 1/ f noise; and 4) the high-energy tail (˜ 1021 eV) of cosmic rays. We review the theoretical and experimental situation regarding these things and go on to propose a double-slit electron diffraction experiment that is aimed at discriminating between QM and SEDS. We show that, in the context of this experiment, for the case of an electron beam focused on just one of the slits, no interference pattern due to the other slit is predicted by QM, while this is not the case for SEDS. A second experiment that could discriminate between QED and SEDS regards a transversely large electron beam including both slits obtained in an insulating wall, where the ZPF is reduced but not vanished. The interference pattern according to SEDS should be

  18. First-principles opacity table of warm dense deuterium for inertial-confinement-fusion applications.

    PubMed

    Hu, S X; Collins, L A; Goncharov, V N; Boehly, T R; Epstein, R; McCrory, R L; Skupsky, S

    2014-09-01

    Accurate knowledge of the optical properties of a warm dense deuterium-tritium (DT) mixture is important for reliable design of inertial confinement fusion (ICF) implosions using radiation-hydrodynamics simulations. The opacity of a warm dense DT shell essentially determines how much radiation from hot coronal plasmas can be deposited in the DT fuel of an imploding capsule. Even for the simplest species of hydrogen, the accurate calculation of their opacities remains a challenge in the warm-dense matter regime because strong-coupling and quantum effects play an important role in such plasmas. With quantum-molecular-dynamics (QMD) simulations, we have derived a first-principles opacity table (FPOT) of deuterium (and the DT mixture by mass scaling) for a wide range of densities from ρ(D)=0.5 to 673.518g/cm(3) and temperatures from T=5000K up to the Fermi temperature T(F) for each density. Compared with results from the astrophysics opacity table (AOT) currently used in our hydrocodes, the FPOT of deuterium from our QMD calculations has shown a significant increase in opacity for strongly coupled and degenerate plasma conditions by a factor of 3-100 in the ICF-relevant photon-energy range. As conditions approach those of classical plasma, the opacity from the FPOT converges to the corresponding values of the AOT. By implementing the FPOT of deuterium and the DT mixture into our hydrocodes, we have performed radiation-hydrodynamics simulations for low-adiabat cryogenic DT implosions on the OMEGA laser and for direct-drive-ignition designs for the National Ignition Facility. The simulation results using the FPOT show that the target performance (in terms of neutron yield and energy gain) could vary from ∼10% up to a factor of ∼2 depending on the adiabat of the imploding DT capsule; the lower the adiabat, the more variation is seen in the prediction of target performance when compared to the AOT modeling.

  19. Expanding the principle of local distinguishability

    NASA Astrophysics Data System (ADS)

    Carmeli, Claudio; Heinosaari, Teiko; Schultz, Jussi; Toigo, Alessandro

    2015-04-01

    The principle of local distinguishability states that an arbitrary physical state of a bipartite system can be determined by the combined statistics of local measurements performed on the subsystems. A necessary and sufficient requirement for the local measurements is that each one must be able to distinguish between all pairs of states of the respective subsystems. We show that, if the task is changed into the determination of an arbitrary bipartite pure state, then at least in certain cases it is possible to restrict to local measurements which can distinguish all pure states but not all states. Moreover, we show that, if the local measurements are such that the purity of the bipartite state can be verified from the statistics without any prior assumption, then in these special cases also this property is carried over to the composite measurement. These surprising facts give evidence that the principle of local distinguishability may be expanded beyond its usual applicability.

  20. [Measurement of human body fat by means of gravimetry. Application of Archimedes' principle].

    PubMed

    Dettwiler, W; Ribordy, M; Donath, A; Scherrer, J R

    1978-12-02

    The weighing of the human body under water is an application of Archimedes' law. Fat being lighter than water or than the structures of lean body mass, body fat can be measured by determining the specific gravity of the human body; that is, by underwater weighing. Body fat has been determined in an "ideal" sample of 14 men and 23 women, all aged 20 years. Testing against a reference measure of body fat makes it possible to test the validity of some anthropometric measurements and of some indices of obesity. These indices offer no advantages over anthropometric measurements.