DOE Office of Scientific and Technical Information (OSTI.GOV)

Susheela, A.K.

Fluorosis, a crippling disease caused by ingesting excess fluoride in drinking water, is a public health problem, affecting people in 20 nations in the world. One of the worst public health problems in the history of mankind known to have occurred and reported about 6 decades ago strangely enough the disease continue to be afflicting millions of people in India, Africa and China with all its severity even during the turn of the century. The present report describes the disease characteristics and the devastating manner in which the disease affects children and adults. The need to bring this to themore » attention of policy, makers, has been attempted.« less

Groundwater arsenic contamination throughout China.

PubMed

Rodríguez-Lado, Luis; Sun, Guifan; Berg, Michael; Zhang, Qiang; Xue, Hanbin; Zheng, Quanmei; Johnson, C Annette

2013-08-23

Arsenic-contaminated groundwater used for drinking in China is a health threat that was first recognized in the 1960s. However, because of the sheer size of the country, millions of groundwater wells remain to be tested in order to determine the magnitude of the problem. We developed a statistical risk model that classifies safe and unsafe areas with respect to geogenic arsenic contamination in China, using the threshold of 10 micrograms per liter, the World Health Organization guideline and current Chinese standard for drinking water. We estimate that 19.6 million people are at risk of being affected by the consumption of arsenic-contaminated groundwater. Although the results must be confirmed with additional field measurements, our risk model identifies numerous arsenic-affected areas and highlights the potential magnitude of this health threat in China.

Impact of the NOx SIP Call on Respiratory Hospitalizations in New York State

EPA Science Inventory

Asthma is a serious public health problem in New York State (NYS), affecting 8.4% (370,000) children and 7.6% (more than 1.1 million) adults. Asthma burden in New York's urban areas is consistently higher than the national average, with marked differences in prevalence and seve...

FCCLA Quilting Project Fights Bullying

ERIC Educational Resources Information Center

Prasad, Vandita

2007-01-01

Bullying in schools is a topic of serious concern. According to a survey conducted in the United States, approximately 30% of youth in grades 6-10 have reported some involvement in moderate or frequent bullying, and this problem affects about 5.7 million youth. To deal with bullying, 2 years ago, Byrnedale Junior High School in Toledo, Ohio…

The importance of economics in fire management analysis

Treesearch

Robert Mavsar; Armando González-Cabán; Verónica Farrera

2010-01-01

Wildfires are a societal problem that threatens many ecosystems, affects millions of people worldwide, and causes major ecosystem and economic impacts at local regional, national and global scales. In Europe, and especially in the Mediterranean countries (France, Greece, Italy, Portugal and Spain), wildfires continue to be a major environmental threat (Requardt et al....

Quantitative Analysis of the Contributing Factors Affecting Specialty Care No-Show Rates at Brooke Army Medical Center

DTIC Science & Technology

2007-03-30

2002). In the Vein Treatment Surgery Center in Texas, failure to properly cancel cosmetic appointments will result in forfeiture of the patients’ $100...appointments. This problem affects more than just the United States. Missed appointments cost the National Healthcare System ( NHS ) in England a...significant amount of money last year. Official figures from the NHS showed 5.7 million appointments were missed in 2004-2005 (Carvel, 2006). When patients

Coping strategies, alexithymia and anxiety in young patients with food allergy.

PubMed

Polloni, L; DunnGalvin, A; Ferruzza, E; Bonaguro, R; Lazzarotto, F; Toniolo, A; Celegato, N; Muraro, A

2017-07-01

Food allergy is major public health concern affecting nearly 15 million Americans and 80 million Europeans. Risk of anaphylaxis and implications for social activities affect patients' quality of life and psychological well-being. We previously found that young patients reported higher levels of alexithymia (difficulty in recognizing and expressing emotions) compared with healthy peers and may influence affect, management style and clinical outcomes. This study aimed to explore links between coping strategies, alexithymia and anxiety among food-allergic adolescents and young adults. Ninety-two patients with IgE-mediated food allergy (mean age 18.6 years) completed Coping Orientation to Problems Experienced Inventory, Toronto Alexithymia Scale and Trait Anxiety subscale of State-Trait Anxiety Inventory. Multivariate analyses of variance assessed differences and associations between subgroups on the scales. Significant differences found between alexithymia levels in coping style were explained by Avoidance strategies. 'Avoidance' had the highest contribution in explaining alexithymia, followed by trait anxiety, age, anaphylaxis and social support. Respondents with higher alexithymia use avoidance as coping strategy over and above other coping strategies such as problem-solving and positive thinking, are younger, will have experienced anaphylaxis and will have lower social support. Recognizing the specific role of affect regulation in health behaviours may constitute an important step in supporting patients to explore more adaptive strategies. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Learning problems, delayed development, and puberty

PubMed Central

Wright, Beverly A.; Zecker, Steven G.

2004-01-01

Language-based learning disorders such as dyslexia affect millions of people, but there is little agreement as to their cause. New evidence from behavioral measures of the ability to hear tones in the presence of background noise indicates that the brains of affected individuals develop more slowly than those of their unaffected counterparts. In addition, it seems that brain changes occurring at ≈10 years of age, presumably associated with puberty, may prematurely halt this slower-than-normal development when improvements would normally continue into adolescence. The combination of these ideas can account for a wide range of previous results, suggesting that delayed brain development, and its interaction with puberty, may be key factors contributing to learning problems. PMID:15210987

The Asian Tsunami and Problem-Based Learning for Postgraduate Students in Sri Lanka

ERIC Educational Resources Information Center

Jayawardana, A. K. L.; O'Donnell, Michael

2007-01-01

The Asian Tsunami struck Sri Lanka on December 26, 2004. Sri Lanka was the second worst affected country after Indonesia, and this natural disaster killed in excess of 35,000 people and displaced over 1 million. The article explores the Tsunami Disaster Management Program developed by one Sri Lankan university: the Postgraduate Institute of…

The Safe Environment for Every Kid (SEEK) Model: Helping Promote Children's Health, Development, and Safety

ERIC Educational Resources Information Center

Dubowitz, Howard

2013-01-01

Child maltreatment affects millions of children each year. health care providers are increasingly called upon to address such psychosocial problems facing many families. In this article, the authors describe a practical approach to further enhance pediatric primary care and make it more responsive to the needs of children and families. The Safe…

STUDIES TO ADDRESS THE ASSOCIATION BETWEEN PARTICULATE MATTER (PM) EXPOSURE AND DEVELOPMENT/EXACERBATION OF LUNG INJURY, INFLAMMATION, AND INCREASED AIRWAY RESPONSIVENESS.

EPA Science Inventory

Asthma, an inflammatory airways disease, has become an urgent health problem affecting an estimated 17 million persons in the United States alone (CDC 1998 MMWR 47). Since 1979, the death rate from asthma has increased by almost 56%. Epidemiologic studies have demonstrated posit...

Modeling a Day in the Life of a Diabetic

ERIC Educational Resources Information Center

Brod, Ryan; Gomber, John; Mendoza, Jurelle; Roginski, Jonathan; Smith, Tyler

2010-01-01

The material presented here was used for a semester-long capstone project for a first semester freshman course entitled Mathematical Modeling and Introduction to Calculus. The goals for the students in this work were twofold: first, enable the students to gain insight into an actual problem that affects millions of people in the United States and…

The SAFRR Tsunami Scenario

USGS Publications Warehouse

Porter, K.; Jones, Lucile M.; Ross, Stephanie L.; Borrero, J.; Bwarie, J.; Dykstra, D.; Geist, Eric L.; Johnson, L.; Kirby, Stephen H.; Long, K.; Lynett, P.; Miller, K.; Mortensen, Carl E.; Perry, S.; Plumlee, G.; Real, C.; Ritchie, L.; Scawthorn, C.; Thio, H.K.; Wein, Anne; Whitmore, P.; Wilson, R.; Wood, Nathan J.; Ostbo, Bruce I.; Oates, Don

2013-01-01

The U.S. Geological Survey and several partners operate a program called Science Application for Risk Reduction (SAFRR) that produces (among other things) emergency planning scenarios for natural disasters. The scenarios show how science can be used to enhance community resiliency. The SAFRR Tsunami Scenario describes potential impacts of a hypothetical, but realistic, tsunami affecting California (as well as the west coast of the United States, Alaska, and Hawaii) for the purpose of informing planning and mitigation decisions by a variety of stakeholders. The scenario begins with an Mw 9.1 earthquake off the Alaska Peninsula. With Pacific basin-wide modeling, we estimate up to 5m waves and 10 m/sec currents would strike California 5 hours later. In marinas and harbors, 13,000 small boats are damaged or sunk (1 in 3) at a cost of $350 million, causing navigation and environmental problems. Damage in the Ports of Los Angeles and Long Beach amount to $110 million, half of it water damage to vehicles and containerized cargo. Flooding of coastal communities affects 1800 city blocks, resulting in $640 million in damage. The tsunami damages 12 bridge abutments and 16 lane-miles of coastal roadway, costing $85 million to repair. Fire and business interruption losses will substantially add to direct losses. Flooding affects 170,000 residents and workers. A wide range of environmental impacts could occur. An extensive public education and outreach program is underway, as well as an evaluation of the overall effort.

Fascioliasis: An Ongoing Zoonotic Trematode Infection

PubMed Central

Nyindo, Mramba; Lukambagire, Abdul-Hamid

2015-01-01

Zoonotic trematode infections are an area of the neglected tropical diseases that have become of major interest to global and public health due to their associated morbidity. Human fascioliasis is a trematode zoonosis of interest in public health. It affects approximately 50 million people worldwide and over 180 million are at risk of infection in both developed and underdeveloped countries. The one health paradigm is an area that seeks to address the problem of zoonotic infections through a comprehensive and sustainable approach. This review attempts to address the major challenges in managing human and animal fascioliasis with valuable insights gained from the one health paradigm to global health and multidisciplinary integration. PMID:26417603

Fascioliasis: An Ongoing Zoonotic Trematode Infection.

PubMed

Nyindo, Mramba; Lukambagire, Abdul-Hamid

2015-01-01

Zoonotic trematode infections are an area of the neglected tropical diseases that have become of major interest to global and public health due to their associated morbidity. Human fascioliasis is a trematode zoonosis of interest in public health. It affects approximately 50 million people worldwide and over 180 million are at risk of infection in both developed and underdeveloped countries. The one health paradigm is an area that seeks to address the problem of zoonotic infections through a comprehensive and sustainable approach. This review attempts to address the major challenges in managing human and animal fascioliasis with valuable insights gained from the one health paradigm to global health and multidisciplinary integration.

Mines and human casualties: a robotics approach toward mine clearing

NASA Astrophysics Data System (ADS)

Ghaffari, Masoud; Manthena, Dinesh; Ghaffari, Alireza; Hall, Ernest L.

2004-10-01

An estimated 100 million landmines which have been planted in more than 60 countries kill or maim thousands of civilians every year. Millions of people live in the vast dangerous areas and are not able to access to basic human services because of landmines" threats. This problem has affected many third world countries and poor nations which are not able to afford high cost solutions. This paper tries to present some experiences with the land mine victims and solutions for the mine clearing. It studies current situation of this crisis as well as state of the art robotics technology for the mine clearing. It also introduces a survey robot which is suitable for the mine clearing applications. The results show that in addition to technical aspects, this problem has many socio-economic issues. The significance of this study is to persuade robotics researchers toward this topic and to peruse the technical and humanitarian facets of this issue.

Forest health restoration in south-central Alaska: a problem analysis.

Treesearch

Darrell W. Ross; Gary E. Daterman; Jerry L. Boughton; Thomas M. Quigley

2001-01-01

A spruce beetle outbreak of unprecedented size and intensity killed most of the spruce trees on millions of acres of forest land in south-central Alaska in the 1990s. The tree mortality is affecting every component of the ecosystem, including the socioeconomic culture dependent on the resources of these vast forests. Based on information obtained through workshops and...

Gaming Against Violence: A Grassroots Approach to Teen Dating Violence.

PubMed

Crecente, Drew

2014-08-01

Teen dating violence is a pervasive problem that affects millions of adolescents worldwide. Although there have been various approaches to addressing this problem, using videogames had not been employed before 2008, when Jennifer Ann's Group, an Atlanta, GA-based nonprofit organization, created an annual competition. The Life.Love. Game Design Challenge rewards game developers for creating videogames about teen dating violence without using any violence in the games themselves. The resulting videogames have increased awareness about teen dating violence and provided educational information to assist adolescents, parents, and teachers in identifying abusive relationships.

Deep-vein thrombosis prevention in orthopaedic patients: affecting outcomes through interdisciplinary education.

PubMed

Hohlt, T

2000-01-01

Deep-vein thrombosis (DVT) is a serious problem that affects millions of people annually. Prophylaxis against DVT following major orthopaedic surgery can save lives and health care dollars. Proper application of the prophylactic regimen by nursing and the interdisciplinary team can be a major key in affecting the outcome of the orthopaedic patient. To obtain successful outcomes, the educational needs of each individual in the interdisciplinary team must be met. Also, being aware of each physician's practice patterns, implementing their individual preferences, and ensuring that all equipment is available and used in a consistent manner will enhance the desired outcome.

Aerial wildland firefighting resources in fire suppression activities: an example USDA Forest Service

Treesearch

A. González-Cabán

2011-01-01

Wildfires are a significant social problem affecting millions of people worldwide and causing major economic impacts at all levels. In the US, the severe fires of 1910 in Idaho and Montana galvanized a fire policy excluding fire from the ecosystem by the U.S.Department of Agriculture Forest Service (USDAFS). Fire management policy changed in 1935, 1978,1995, and 2001....

Prevalence and Risk Factors of Obesity among Elderly Attending Geriatric Outpatient Clinics in Mansoura City

ERIC Educational Resources Information Center

Shebl, Amany Mohamed; Hatata, El Sayed Zaki; Boughdady, Aziza Mahmoud; El-Sayed, Sally Mohammed

2015-01-01

Obesity is a major public health problem affecting all ages in both developed and developing countries. It is considered the fifth leading risk factor for deaths all over the world as about 2.8 million people die due to obesity each year directly or indirectly. Obesity in elderly is considered one of the most serious public health challenges for…

The Development and Validation of a Domestic Violence Scale Administered to GED Program Participants to Determine the Effect on Test Performance

ERIC Educational Resources Information Center

Muro, Andres

2013-01-01

Overwhelming evidence shows that domestic violence is a very serious problem affecting women in the United States. Black et al. (2010) report that approximately 34 million women in the United States, or approximately 30%, have experienced some form of violence including rape, physical, violence, and/or stalking in their lifetimes. Twenty-two…

[Frequency and consequences of financial problems in patients undergoing outpatient psychosomatic treatment].

PubMed

Wagner, Stefanie; Münster, Eva; Beutel, Manfred E

2010-01-01

About seven million people in Germany are affected by overindebtedness and insolvency. Being severely in debt is a very stressful situation that can result in social marginalisation, reducted overall activity, and physical and mental illness. The present study investigated the frequency of financial problems and their effects on physical and mental disorders at a university psychosomatic clinic. The study included a total of 659 patients. Their mental status was assessed with the Symptom Checklist (SCL-90-R), their physical status with the Gießener Beschwerdebogen (GBB). 37 percent of the subjects reported experiencing financial problems. We found that subjects with financial problems reported more physical and mental disorders than those without financial problems. Furthermore, therapists more often recommended that patients with financial problems receive inpatient therapy than patients without financial problems. The study suggests that financial problems should be included in any anamnesis, therapeutic recommendation, and actual therapy of patients in psychosomatic treatment.

Arsenic in the groundwater: Occurrence, toxicological activities, and remedies.

PubMed

Jha, S K; Mishra, V K; Damodaran, T; Sharma, D K; Kumar, Parveen

2017-04-03

Arsenic (As) contamination in groundwater has become a geo-environmental as well as a toxicological problem across the globe affecting more than 100-million people in nearly 21 countries with its associated disease "arsenicosis." Arsenic poisoning may lead to fatal skin and internal cancers. In present review, an attempt has been made to generate awareness among the readers about various sources of occurrence of arsenic, its geochemistry and speciation, mobilization, metabolism, genotoxicity, and toxicological exposure on humans. The article also emphasizes the possible remedies for combating the problem. The knowledge of these facts may help to work on some workable remedial measure.

International Conference on Aerosols, Clouds and the Indian Monsoon

NASA Astrophysics Data System (ADS)

Singh, Ramesh P.; Tare, Vinod; Tripathi, S. N.

2005-06-01

In recent years, dense haze and fog problems in the northern parts of India have affected the 460 million people living in the Indo-Gangetic basin. Substantial Indian research activities related to aerosols, clouds, and monsoon are taking place in the central and southern parts of India. To attract attention to the problems, a three-day International Conference on Aerosols, Clouds and Indian Monsoon was recently held at the Indian Institute of Technology, Kanpur, in the central part of the Indo-Gangetic basin. About 120 delegates from India, Germany, Greece, Japan, Taiwan, and the United States attended the conference.

Asthma and Chronic Obstructive Pulmonary Disease (COPD) – Differences and Similarities

PubMed Central

Cukic, Vesna; Lovre, Vladimir; Dragisic, Dejan; Ustamujic, Aida

2012-01-01

Bronchial asthma and COPD (chronic obstructive pulmonary disease) are obstructive pulmonary diseases that affected millions of people all over the world. Asthma is a serious global health problem with an estimated 300 million affected individuals. COPD is one of the major causes of chronic morbidity and mortality and one of the major public health problems worldwide. COPD is the fourth leading cause of death in the world and further increases in its prevalence and mortality can be predicted. Although asthma and COPD have many similarities, they also have many differences. They are two different diseases with differences in etiology, symptoms, type of airway inflammation, inflammatory cells, mediators, consequences of inflammation, response to therapy, course. Some similarities in airway inflammation in severe asthma and COPD and good response to combined therapy in both of these diseases suggest that they have some similar patophysiologic characteristics. The aim of this article is to show similarities and differences between these two diseases. Today asthma and COPD are not fully curable, not identified enough and not treated enough and the therapy is still developing. But in future better understanding of pathology, adequate identifying and treatment, may be and new drugs, will provide a much better quality of life, reduced morbidity and mortality of these patients. PMID:23678316

Update on the prevalence of malnutrition among children in Asia.

PubMed

Khor, Geok Lin

2003-12-01

Approximately 70.0% of the world's malnourished children live in Asia, resulting in the region having the highest concentration of childhood malnutrition. About half of the preschool children are malnourished ranging from 16.0% in the People's Republic of China to 64.0% in Bangladesh. Prevalence of stunting and underweight are high especially in South Asia where one in every two preschool children is stunted. Besides protein-energy malnutrition, Asian children also suffer from micronutrient deficiency. Iron deficiency anaemia affects 40.0-50.0% of preschool and primary school children. Nearly half of all vitamin A deficiency and xeropthalmia in the world occurs in South and Southeast Asia, with large numbers of cases in India (35.3 million), Indonesia (12.6 million) and China (11.4 million). Another major micronutrient problem in the region is iodine deficiency disorders, which result in high goiter rates as manifested in India, Pakistan and parts of Indonesia. While under-nutrition problem persists, overweight problem in children has emerged in Asia, including Taiwan, Singapore and urban China and Malaysia. The etiology of childhood malnutrition is complex involving interactions of multiple determinants that include biological, cultural and socio-economic influences. Protein-energy malnutrition and micronutrient deficiency leading to early growth failure often can be traced to poor maternal nutritional and health care before and during pregnancy, resulting in intrauterine growth retardation and children born with low birth weight. While significant progress has been achieved over the past 30 years in reducing the proportion of malnourished children in developing countries, nonetheless, malnutrition persists affecting large numbers of children. The socio-economic cost of the malnutrition burden to the individual, family and country is high resulting in lower cognitive outcomes in children and lower adult productivity. Interventions that are cost-effective and culturally appropriate for the elimination of childhood malnutrition deserve the support of all.

International refugees: a geographical perspective.

PubMed

Demko, G J; Wood, W B

1987-01-01

In the modern era, the world's refugee problem has changed magnitude and location; it has expanded from a local to a continental, and now global, scale issue. About 90% of the world's 10 million refugees are from developing countries, and over 90% of these will stay there. Refugee generating and receiving countries are concentrated in 5 world regions: Central America, Southwest Asia, Southeast Asia, and Sub-Saharan Africa. Each concentration is unique and is associated with a particular set of regional conflicts. International efforts address short-term relief needs, whereas political instability and repression that generate refugees continue unabated. Refugees along sensitive border regions affect bilateral relations, large groups of refugees can pose political and security problems for the host country, and disputes over refugee policies and their implementation can complicate diplomatic ties. Some highlights of the data follow. 1) The 3 million cross-border refugees and 5.5 million internally displaced persons make the many governments in Sub-Saharan Africa increasingly dependent on Western assistance to solve their problems. Refugees are fleeing armed conflict, tribal violence, and drought, and often generate additional regional turmoil. 2) 3-4 million Afghans have fled their country since the 1978 Marxist coup; about 2.5 million have entered Pakistan. Most choose to remain in camps near the Afghanistan border where they are targets of cross-border attacks. 3) 1.2 million Salvadorans, Guatemalans, and Nicaraguans live outside their native countries. Official refugee and unofficial migrant populations are active in various rebel insurgencies, contribute to strained bilateral relations and tensions in border areas, and are the subject of heated political debate in host countries. 4) 90% of the 1.7 million Indochinese who fled from 1975-May 1986 have been resettled; 168,000 refugees remain in 1st-asylum camps, not including 240,000 Khmer without refugee status, in temporary camps in Thailand. Thailand's large refugee population is involved in factional strife, smuggling, and guerrilla activities. The Thai are particularly concerned about Hmong refugees, who are accused of opium cultivation and destruction of Thai forests through slash-and-burn cultivation. 5) Nearly 62% of the thousands of present Vietnamese refugees to Hong Kong have been in camps 3 years, and 17% 6 years. Many have turned to crime, alcohol, drugs, or prostitution.

[A problem-posing educational methodology for the prevention of HIV / AIDS].

PubMed

Magana, J R; Ferreira-pinto, J B; Blair, M; Mata A

1992-01-01

The problem-posing methodology of Brazilian educator Paulo Freire, using the reading circle approach previously deployed in successful literacy campaigns in developing countries, is introduced for application in AIDS information programs. The basis of this educational process is the dialogue where those to be educated resolve their problems by evaluating information critically, capturing concepts by codification and decodification, and transmitting information by creating relevant educational materials. Health circles are organized with women as educators to impart knowledge about AIDS and HIV: definitions, epidemiological components (sex, age, and risk behavior), means of transmission, stages of the progression of AIDS, prevention of HIV infection, and tests for detecting HIV antibodies. The dialogue explores knowledge and feelings about AIDS and how it affects life in the community reveals personal experiences and accounts of knowing someone who was HIV-positive, and develops action plans to minimize AIDS cases in the community. The Latin population of California, mainly of Mexican origin, with low levels of education, income, and acculturation and a high incidence of AIDS, is an appropriate target of such intervention. In 1980, there were 12.3 million people of Hispanic origin in the US. In August 1990, there were 143,280 persons diagnoses with AIDS according to the Centers for Disease Control. 78,878 of these (55%) were Anglos, and 21,752 (15%) were Hispanics. Among the Anglos, the incidence was 300/million inhabitants, while among Hispanics, it was 1059/million, a 3-field higher rate.

Colworth prize lecture 2016: exploiting new biological targets from a whole-cell phenotypic screening campaign for TB drug discovery.

PubMed

Moynihan, Patrick Joseph; Besra, Gurdyal S

2017-10-01

Mycobacterium tuberculosis is the aetiological agent of tuberculosis (TB) and is the leading bacterial cause of mortality and morbidity in the world. One third of the world's population is infected with TB, and in conjunction with HIV represents a serious problem that urgently needs addressing. TB is a disease of poverty and mostly affects young adults in their productive years, primarily in the developing world. The most recent report from the World Health Organisation states that 8 million new cases of TB were reported and that ~1.5 million people died from TB. The efficacy of treatment is threatened by the emergence of multi-drug and extensively drug-resistant strains of M. tuberculosis. It can be argued that, globally, M. tuberculosis is the single most important infectious agent affecting mankind. Our research aims to establish an academic-industrial partnership with the goal of discovering new drug targets and hit-to-lead new chemical entities for TB drug discovery.

The impact of health literacy on cardiovascular disease

PubMed Central

Safeer, Richard S; Cooke, Catherine E; Keenan, Jann

2006-01-01

One's ability to read, listen, and comprehend health information is a vital element of maintaining and improving health. However, 90 million people in the United States exhibit less than adequate health literacy skills. Given that more than 70 million Americans suffer from cardiovascular diseases, it is certain that every physician's practice is affected by health literacy issues. Those with language and cultural issues tend to be the most affected. Yet numerous studies find physicians do a poor job of assessing their patients’ health literacy skills. Patients are also unaware of the steps they should take, and how to take them, to improve their health and prevent complications. Numerous studies find, however, that outcomes can be improved with targeted patient education and improved physician communication skills that take into account patients’ health literacy levels. Unfortunately, the health care system is only beginning to recognize this problem and take action to overcome its negative impact. By improving the communication process with patients, physicians may be able to improve cardiovascular outcomes. PMID:17323600

Air pollution: impact and prevention.

PubMed

Sierra-Vargas, Martha Patricia; Teran, Luis M

2012-10-01

Air pollution is becoming a major health problem that affects millions of people worldwide. In support of this observation, the World Health Organization estimates that every year, 2.4 million people die because of the effects of air pollution on health. Mitigation strategies such as changes in diesel engine technology could result in fewer premature mortalities, as suggested by the US Environmental Protection Agency. This review: (i) discusses the impact of air pollution on respiratory disease; (ii) provides evidence that reducing air pollution may have a positive impact on the prevention of disease; and (iii) demonstrates the impact concerted polices may have on population health when governments take actions to reduce air pollution. © 2012 The Authors. Respirology © 2012 Asian Pacific Society of Respirology.

Treating malnutrition in the community.

PubMed

Dera, Merceline; Woodham, Diane

2016-11-02

Malnutrition is a clinical and public health problem. It has adverse effects on the physical and psycho-social wellbeing of individuals by predisposing to disease, negatively affecting its outcome and reducing the likelihood of independence. An estimated 3 million people in the UK are affected by malnutrition, most of whom live in the community ( BAPEN, 2011 ). Despite the scale of this problem, it remains under-detected, under-treated, underresourced and often overlooked by those involved in the care of at risks individuals such as the elderly. In most cases malnutrition is a treatable condition that can be managed by optimising food intake and using oral nutritional supplements (ONS) where necessary. The main focus of this article is on the dangers of malnutrition for older people in the community and the use of ONS in the treatment and management of malnutrition.

An overview of University of Alaska Anchorage, ENRI research on the spruce bark beetle infestation, Kenai Peninsula, Alaska, 1997-2002

Treesearch

Vernon J. LaBau

2006-01-01

In the mid 1990s, one of the largest bark beetle infestations seen anywhere in the world occurred on the Kenai Peninsula of Alaska. In one year, the infestation affected over one million acres of spruce in Alaska. This paper presents a coalescence of several aspects of study on the problem, including tree inventory and mortality, regeneration, understory response, a...

Hearing loss research from NIH | NIH MedlinePlus the Magazine

MedlinePlus

... loss affects millions Follow us By the Numbers: Hearing Loss Affects Millions Approximately 15 percent of American ... million) aged 18 and over report some trouble hearing. That makes it the third most chronic health ...

[The newborn infant of a mother with tuberculosis].

PubMed

Pedicino, R; Bressan, K; Bedetta, M

2010-06-01

TBC is a major infectious emergency in the world. OMS suggest that there are 8 millions of affected every year and 2 millions of deaths. Italy is considered a country with low prevalence, but the increase of the immigration from Africa Asia and Est Europa (country with high risk) imposes attention to the problem. The delivery is a critical moment to investigate people at risk of disease. The infection of the newborn can happen intrauterine or in the expulsive period, but is possible also at home, from somebody affected by an active pulmonary disease. Diagnosis in the newborn is not easy for the aspecificity of clinical signs and for the frequent initial negativeness of Mantoux test. Culture of placenta, gastric aspirate, tracheal secretions, urine would be requested, cerebrospinal fluid if necessary. Neonatal disease needs therapy with isoniazide, rifampicine, pirazinamide and, or ethambutol, or streptomycin. Profilaxis of a newborn from a woman affected by an active form of tuberculosis or living with people affected by an active pulmonary form consists in giving isoniazide until diagnostic tests are negative and in removing the sicks (only with pulmonary disease). New dangerous kinds of pharmacological multiresistent tuberculosis are appeared in the last years in the world and, with the coinfection HIV-TBC and the reorganization of the surveillance system, represents the major obligation for the next years.

Innate Immunity against Leishmania Infections

PubMed Central

Gurung, Prajwal; Kanneganti, Thirumala-Devi

2015-01-01

Leishmaniasis is a major health problem that affects more than 300 million people throughout the world. The morbidity associated with the disease causes serious economic burden in Leishmania endemic regions. Despite the morbidity and economic burden associated with Leishmaniasis, this disease rarely gets noticed and is still categorized under neglected tropical diseases. The lack of research combined with the ability of Leishmania to evade immune recognition has rendered our efforts to design therapeutic treatments or vaccines challenging. Herein, we review the literature on Leishmania from innate immune perspective and discuss potential problems as well as solutions and future directions that could aid in identifying novel therapeutic targets to eliminate this parasite. PMID:26249747

Reproductive Tract Infections in Rural Vietnam, Women's Knowledge, and Health-Seeking Behavior: A Cross-Sectional Study.

PubMed

Nielsen, Anna; Lan, Pham Thi; Marrone, Gaetano; Phuc, Ho Dang; Chuc, Nguyen Thi Kim; Stålsby Lundborg, Cecilia

2016-01-01

We interviewed 1,805 women in a rural setting in Vietnam with the aim of investigating women's knowledge regarding reproductive tract infections (RTIs) and their health-seeking behavior. We found that women's overall knowledge was poor. Furthermore, only one-third of the symptomatic women sought health care. RTIs affect millions of women globally each year. Most vulnerable are women in low- and middle-income countries where poverty and gender inequities affect their access to health care services. Findings from our study can be used in similar rural settings worldwide to understand and manage the widespread problem of RTIs.

Saving lives in road traffic—ethical aspects

PubMed Central

2009-01-01

Aim This article aims at giving an overview of five ethical problem areas relating to traffic safety, thereby providing a general framework for analysing traffic safety from an ethical perspective and encouraging further discussion concerning problems, policies and technology in this area. Subjects and methods The problems presented in the article are criminalisation, paternalism, privacy, justice and responsibility, and the reasons for choosing these are the following. First, they are all important areas in moral philosophy. Second, they are fairly general and it should be possible to categorise more specific problems under these headings. Ethical aspects of road traffic have not received the philosophical attention they deserve. Every year, more than 1 million people die globally in traffic accidents, and 20 to 50 million people are injured. Ninety per cent of the road traffic fatalities occur in low- and middle-income countries, where it is a growing problem. Politics, economics, culture and technology affect the number of fatalities and injuries, and the measures used to combat deaths in traffic as well as the role of road traffic should be ethically scrutinised. The topics are analysed and discussed from a moral-philosophical perspective, and the discussion includes both theory and applications. Results and conclusion The author concludes with some thoughts on how the ethical discussion can be included in the public debate on how to save lives in road traffic. People in industrialised societies are so used to road traffic that it is almost seen as part of nature. Consequently, we do not acknowledge that we can introduce change and that we can affect the role we have given road traffic and cars. By acknowledging the ethical aspects of road traffic and illuminating the way the choices society makes are ethically charged, it becomes clear that there are alternative ways to design the road traffic system. The most important general conclusion is that discussion concerning these alternative ways of designing the system should be encouraged. PMID:21088693

Children’s Contact With Their Incarcerated Parents

PubMed Central

Poehlmann, Julie; Dallaire, Danielle; Loper, Ann Booker; Shear, Leslie D.

2014-01-01

Approximately 1.7 million children have parents who are incarcerated in prison in the United States, and possibly millions of additional children have a parent incarcerated in jail. Many affected children experience increased risk for developing behavior problems, academic failure, and substance abuse. For a growing number of children, incarcerated parents, caregivers, and professionals, parent– child contact during the imprisonment period is a key issue. In this article, we present a conceptual model to provide a framework within which to interpret findings about parent– child contact when parents are incarcerated. We then summarize recent research examining parent–child contact in context. On the basis of the research reviewed, we present initial recommendations for children’s contact with incarcerated parents and also suggest areas for future intervention and research with this vulnerable population. PMID:20822198

Counting 15 million more poor in India, thanks to tobacco.

PubMed

John, Rijo M; Sung, Hai-Yen; Max, Wendy B; Ross, Hana

2011-09-01

To quantify the impact of tobacco use and the related medical expenditure on poverty in India. Tobacco expenditure and associated medical expenditure attributable to tobacco use were subtracted from the household monthly consumption expenditure in order to derive an appropriate measure of household disposable income. The 2004 National Sample Survey, a nationally representative survey of Indian households, was used to estimate the true level of poverty. Our estimates indicate that accounting for direct expenditure on tobacco would increase the rural and the urban poverty rates by 1.5% (affecting 11.8 million people) and 0.72% (affecting 2.3 million people), respectively. Similarly, the out-of-pocket costs of tobacco-attributable medical care result in 0.09% higher poverty rates in rural areas (affecting 0.7 million people) and in 0.07% higher poverty rates in urban locations (affecting 0.23 million people). Tobacco consumption impoverishes roughly 15 million people in India. Hence tobacco control measures would not only improve public health, but would also reduce poverty in India.

The financial impact of unrepaired cleft lip and palate in the Philippines.

PubMed

Muntz, Harlan R; Meier, Jeremy D

2013-12-01

There are over 96 million people in the Philippines. Close to 77 thousand persons in this country have orofacial clefting. We estimate nearly 64 thousand are unrepaired. Unemployment and underemployment because of the communication disorders associated with unrepaired clefts will affect family income and hence tax revenues. The purpose of this study is to understand the financial impact of unrepaired cleft lip and/or palate on families and identify how that would translate to the Philippine government in tax revenues. The incidence of orofacial cleft in the Philippines was estimated to be at least 1 in 750 people, with only 16% anticipated to be repaired under current conditions. Assuming a 21% unemployment rate in subjects with untreated clefts, and a tax rate of 6-12.4%, projected lost personal income and federal tax revenue was calculated. In 2012 alone the financial impact on the families may be as much as $US 73-88 million in lost revenue from unemployment and underemployment. This would cost the government between $8.0 and $9.8 million dollars in lost tax revenue. Over a 20 year period at least $US 1.7 billion dollars in family income would be affected costing the government at least $US 194 million in taxes. By appropriately caring for the cleft population tax revenues should increase substantially. The development of the infrastructure for surgical care of this problem would be costly but could be more than offset by revenues. Inattention to surgically correctable causes of communication disorders is not affordable. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Effect of Population Growths on Water Resources in Dubai Emirate, United Arab Emirates

NASA Astrophysics Data System (ADS)

Al-Nuaimi, Hind S.; Murad, Ahmed A.

The Emirate of Dubai is situated to the north of the United Arab Emirates on the Arabian Gulf. Due to its political stability and strong economy, people are continuing to immigrate to Dubai and this will enhance the stress on water resources. Therefore, demands for water will increase significantly in Dubai. The scarcity of water resources in Dubai is evident. The total production of water in the Dubai has increased to 61,478 million gallons in 2004. About 58,808 million gallons has been produced from the desalination plants in 2004. The production of freshwater from the main aquifers is about 2763 and 2655 million gallons for the years 2003 and 2004, respectively. The reduction of groundwater in 2004 may be ascribed to the low amount of rainfall and to the decreasing capacity of the aquifers. Treated wastewater is another source for water whose quantity was increased from 72 m3 to about 107 m3 in 2000 and 2004, respectively. The increase in water production in Dubai to meet the demand corresponds to population growth and this might be attributed to the political stability and strong economy. Moreover, major problems related to the water resources have appeared and affected the availability of freshwater in Dubai. These problems include: lowering water level and groundwater deterioration. This paper is aimed to assess the impacts of population growth on water resources in Dubai.

Male infertility: an overview of causes and treatment options.

PubMed

Leaver, Rachel Busuttil

2016-10-13

It is estimated that 3.5 million people in the UK, that is one in every seven couples, have fertility problems. In the past, it was assumed that the cause always lay with the woman. However, developments in science brought a greater understanding of the process of sperm production and conception. It is now known that up to 30% of fertility problems may be because of the man alone and up to 90% of these are down to low sperm count or low sperm quality or both. This paper offers a review of the causes and potential factors that affect male fertility together with an overview of diagnosis, investigation and current treatment options for these men.

THE SCOPE OF THE DROPOUT PROBLEM, AN EDUCATOR LOOKS AT THE DROPOUT PROBLEM.

ERIC Educational Resources Information Center

SCHREIBER, DANIEL

THOUGH THE PROPORTION OF DROPOUTS IN THE U.S. IS SLOWLY DIMINISHING, THE NUMBER OF DROPOUTS DURING THE PRESENT DECADE IS EXPECTED TO SOAR UNPRECEDENTEDLY. OF 26 MILLION YOUNG PEOPLE WHO WILL GO FROM SCHOOLS INTO THE LABOR MARKET, 7 1/2 MILLION WILL BE DROPOUTS, AND 2 1/2 MILLION OF THE DROPOUTS WILL HAVE HAD LESS THAN 8 YEARS OF SCHOOLING. UNTIL…

Social Work Practice in Health Care: The Need to Use Brief Interventions

ERIC Educational Resources Information Center

Kotrla, Kim

2005-01-01

According to the National Institute on Alcohol Abuse and Alcoholism (NIAAA) (2001), 14 million U.S. adults abuse alcohol and several million more are at risk of developing alcohol problems because of their drinking behaviors. Heavy drinking increases the risk of serious health problems, with the economic cost of problem drinking estimated to be…

Fluoride distribution and contamination in the water, soil and plants continuum and its remedial technologies, an Indian perspective- a review.

PubMed

Singh, Gayatri; Kumari, Babita; Sinam, Geetgovind; Kriti; Kumar, Navin; Mallick, Shekhar

2018-04-09

Fluorine is an essential element required in trace amounts but gets toxic for human beings at levels more than 1.5 mg F - L -1 primarily through drinking contaminated water. It is the 13th most abundant element and constitutes about 0.06-0.09% in the earth crust. It is electronegative in aqueous medium forming fluoride ion (F - ). Fluoride contamination in the environment occurs mostly due to anthropogenic and geogenic sources. Fluoride is widely distributed in all components of environment, air (0.1-0.6 μg L -1 ) soils (150-400 mg Kg -1 ) rocks (100-2000 mg Kg -1 ), plant (0.01-42 mg Kg -1 ) and water (1.0-38.5 mg L -1 ). Human beings and animals are being exposed to F - primarily from water (0.2-42.0 mg L -1 ) and plants (0.77-29.5 μg g -1 ). Fluorosis, a health hazard due to F - is a major problem in many countries across the world affecting about 200 million people globally. In India, > 62 million people in twenty states are facing problem due to F - . The most affected states are Rajasthan (7670 habitations), Telangana (1,174 habitations) and Karnataka (1122 habitations). To mitigate this problem, there is an urgent need to understand the current status and brief knowledge of F - geochemistry. The objective of this review is to highlight different sources of F - that contaminate different environmental matrices including plants, the extent of contamination level in India, uptake, translocation and toxicity mechanism in plants. The review also highlights currently available mitigation methods or technologies through physio-chemical and biological means. Copyright © 2018 Elsevier Ltd. All rights reserved.

Children's contact with their incarcerated parents: research findings and recommendations.

PubMed

Poehlmann, Julie; Dallaire, Danielle; Loper, Ann Booker; Shear, Leslie D

2010-09-01

Approximately 1.7 million children have parents who are incarcerated in prison in the United States, and possibly millions of additional children have a parent incarcerated in jail. Many affected children experience increased risk for developing behavior problems, academic failure, and substance abuse. For a growing number of children, incarcerated parents, caregivers, and professionals, parent-child contact during the imprisonment period is a key issue. In this article, we present a conceptual model to provide a framework within which to interpret findings about parent-child contact when parents are incarcerated. We then summarize recent research examining parent-child contact in context. On the basis of the research reviewed, we present initial recommendations for children's contact with incarcerated parents and also suggest areas for future intervention and research with this vulnerable population. Copyright 2010 APA, all rights reserved.

[Prevalence of pleural malignant mesothelioma in Poland in 1980-1993].

PubMed

Szeszenia-Dabrowska, N; Szymczak, W; Wilczyńska, U

1996-01-01

Malignant pleural mesothelioma is subject of special interest for environmental epidemiologists due to its proven cause-effect relationship with the exposure to asbestos dust, particularly crocidolite. The paper discusses the prevalence trends and geographical distribution of pleural mesothelioma in Poland based on the death rate analysis. In 1993 the crude death rate for that neoplasm was found to be 4.48 per 1 million for men and 3.14 per 1 million for women. While interpreting the numerical data, such aspects were considered as the problems with histopathological diagnosis of pleural mesothelioma; the long latency period of 30-40 years; and consequently, the possibility that for the male population the results may have been affected by other causes of death owing to its relatively short average lifespan. The volume and types of asbestos used in Poland were also taken into account.

Prevalence and causes of vision loss in high-income countries and in Eastern and Central Europe in 2015: magnitude, temporal trends and projections

PubMed Central

Cicinelli, Maria Vittoria; Das, Aditi; Flaxman, Seth R; Friedman, David S; Keeffe, Jill E; Kempen, John H; Limburg, Hans; Naidoo, Kovin; Pesudovs, Konrad; Peto, Tunde; Saadine, Jinan; Silvester, Alexander J; Tahhan, Nina; Taylor, Hugh R; Varma, Rohit; Wong, Tien Y

2018-01-01

Background Within a surveillance of the prevalence and causes of vision impairment in high-income regions and Central/Eastern Europe, we update figures through 2015 and forecast expected values in 2020. Methods Based on a systematic review of medical literature, prevalence of blindness, moderate and severe vision impairment (MSVI), mild vision impairment and presbyopia was estimated for 1990, 2010, 2015, and 2020. Results Age-standardised prevalence of blindness and MSVI for all ages decreased from 1990 to 2015 from 0.26% (0.10–0.46) to 0.15% (0.06–0.26) and from 1.74% (0.76–2.94) to 1.27% (0.55–2.17), respectively. In 2015, the number of individuals affected by blindness, MSVI and mild vision impairment ranged from 70 000, 630 000 and 610 000, respectively, in Australasia to 980 000, 7.46 million and 7.25 million, respectively, in North America and 1.16 million, 9.61 million and 9.47 million, respectively, in Western Europe. In 2015, cataract was the most common cause for blindness, followed by age-related macular degeneration (AMD), glaucoma, uncorrected refractive error, diabetic retinopathy and cornea-related disorders, with declining burden from cataract and AMD over time. Uncorrected refractive error was the leading cause of MSVI. Conclusions While continuing to advance control of cataract and AMD as the leading causes of blindness remains a high priority, overcoming barriers to uptake of refractive error services would address approximately half of the MSVI burden. New data on burden of presbyopia identify this entity as an important public health problem in this population. Additional research on better treatments, better implementation with existing tools and ongoing surveillance of the problem is needed. PMID:29545417

Overt and subtle discrimination, subjective well-being and physical health-related quality of life in an obese sample.

PubMed

Magallares, Alejandro; Benito de Valle, Pilar; Irles, Jose Antonio; Jauregui-Lobera, Ignacio

2014-10-27

Obesity represents a serious health issue affecting millions of people in Western industrialized countries. The severity of the medical problems it causes is paralleled by the fact that obesity has become a social stigma that affects the psychological health-related quality of life of individuals with weight problems. Our study, with 111 obese patients of a Spanish hospital, focused specifically on how overt and subtle discrimination is related to subjective well-being (affect balance and life satisfaction) and physical health-related quality of life. It was shown that overt (r = -.28, p < .01 with affect balance; r = -.26, p < .01 with life satisfaction) and subtle discrimination (r = -.28, p < .01 with affect balance; r = -.27, p < .01 with life satisfaction) were negatively linked with subjective well-being, and that there was a negative correlation between overt discrimination and physical health-related quality of life (r = -.26, p < .01). Additionally, it was found that overt discrimination was a mediator variable in the relationship between physical health-related quality of life and subjective well-being using the Baron and Kenny procedure. Finally, it is discussed the relationship between discrimination, subjective well-being and physical health-related quality of life in obese people.

Genetics Home Reference: Jacobsen syndrome

MedlinePlus

... varies among affected individuals, with most affected people missing 5 million to 16 million DNA building blocks ( ... translocation can have a chromosomal rearrangement with some missing genetic material and some extra genetic material. Individuals ...

The global problem of blindness and visual dysfunction

NASA Astrophysics Data System (ADS)

Lakshminarayanan, Vasudevan

2012-10-01

According to World Health Organization statistics there are approximately 285 million people who are blind, have severe low vision, or are near-blind. Of these, 39 million are blind, and 246 million have low vision problems. About 90% of these live in developing countries. The major causes are uncorrected refractive errors (42%), and cataracts (38%). In the US, there are about 6 million people over the age of 65 who have age-related macular degeneration which is the leading cause of blindness. For each decade after age 40, it is found that there is a three-fold increase in the prevalence of blindness and low vision. This paper will address the question of what can we, as optical physicists and engineers, do? There is a need for efficient methods to detect problems, investigate function, provide solutions, and develop rehabilitation devices for the visually impaired. Here I will sketch out the magnitude and variety of the problem, examples and future research directions.

A review of global outlook on fluoride contamination in groundwater with prominence on the Pakistan current situation.

PubMed

Rasool, Atta; Farooqi, Abida; Xiao, Tangfu; Ali, Waqar; Noor, Sifat; Abiola, Oyebamiji; Ali, Salar; Nasim, Wajid

2017-12-19

Several million people are exposed to fluoride (F - ) via drinking water in the world. Current review emphasized the elevated level of fluoride concentrations in the groundwater and associated potential health risk globally with a special focus on Pakistan. Millions of people are deeply dependent on groundwater from different countries of the world encompassing with an elevated level of fluoride. The latest estimates suggest that around 200 million people, from among 25 nations the world over, are under the dreadful fate of fluorosis. India and China, the two most populous countries of the world, are the worst affected. In Pakistan, fluoride data of 29 major cities are reviewed and 34% of the cities show fluoride levels with a mean value greater than 1.5 mg/L where Lahore, Quetta and Tehsil Mailsi are having the maximum values of 23.60, 24.48, > 5.5 mg/L, respectively. In recent years, however, other countries have minimized, even eliminated its use due to health issues. High concentration of fluoride for extended time period causes adverse effects of health such as skin lesions, discoloration, cardiovascular disorders, dental fluorosis and crippling skeletal fluorosis. This review deliberates comprehensive strategy of drinking water quality in the global scenario of fluoride contamination, especially in Pakistan with prominence on major pollutants, mitigation technologies, sources of pollution and ensuing health problems. Considering these verities, health authorities urgently need to establish alternative means of water decontamination in order to prevent associated health problems.

Electronic Nose To Detect Patients with COPD From Exhaled Breath

NASA Astrophysics Data System (ADS)

Velásquez, Adriana; Durán, Cristhian M.; Gualdron, Oscar; Rodríguez, Juan C.; Manjarres, Leonardo

2009-05-01

To date, there is no effective tool analysis and detection of COPD syndrome, (Chronic Obstructive Pulmonary Disease) which is linked to smoking and, less frequently to toxic substances such as, the wood smoke or other particles produced by noxious gases. According to the World Health Organization (WHO) estimates of this disease show it affects more than 52 million people and kills more than 2.7 million human beings each year. In order to solve the problem, a low-cost Electronic Nose (EN) was developed at the University of Pamplona (N. S) Colombia, for this specific purpose and was applied to a sample group of patients with COPD as well as to others who were healthy. From the exhalation breath samples of these patients, the results were as expected; an appropriate classification of the patients with the disease, as well as from the healthy group was obtained.

The cost-effectiveness of insulin glargine vs. neutral protamine Hagedorn insulin in type 2 diabetes: a focus on health economics.

PubMed

Levin, P

2008-07-01

Diabetes mellitus is a major public health problem, in particular because of long-term complications affecting essential organs, such as the eyes and kidneys, which can lead to a reduction in life expectancy and high healthcare costs. The number of individuals with diabetes mellitus is projected to rise worldwide from 171 million people in 2000 to 366 million people in 2030. With the number of patients with diabetes continually growing, the burden of pressure on worldwide health systems is huge. Accordingly, regulatory and marketing approvals of new medicines are beginning to incorporate economic evaluation techniques to determine their cost-effectiveness. Overall, the studies included in this review show that the initiation of insulin glargine is cost-effective and is expected to lead to substantial improvements in both life years (LYs) and quality-adjusted LYs compared with neutral protamine Hagedorn insulin.

A systematic review of Gymnema sylvestre in obesity and diabetes management.

PubMed

Pothuraju, Ramesh; Sharma, Raj Kumar; Chagalamarri, Jayasimha; Jangra, Surender; Kumar Kavadi, Praveen

2014-03-30

The prevalence of obesity is associated with many health-related problems. Currently, more than 300 million people are considered to be obese. According to the World Health Organization (WHO), by 2030, 87 and 439 million people will be affected in India and the world, respectively. Today, herbal medicines are gaining interest in the treatment of obesity and diabetes, because of their minimal side effects. Gymnemic acid - an active component isolated from Gymnema sylvestre - has anti-obesity and antidiabetic properties, decreases body weight and also inhibits glucose absorption. Several components extracted from Gymnema prevent the accumulation of triglycerides in muscle and liver, and also decrease fatty acid accumulation in the circulation. In this paper, an attempt has been made to review the effects of various extracts from Gymnema sylvestre in the regulation of carbohydrate and lipid metabolism in both animal and clinical studies. © 2013 Society of Chemical Industry.

Untoward penicillin reactions

PubMed Central

Guthe, T.; Idsöe, O.; Willcox, R. R.

1958-01-01

The literature on untoward reactions following the administration of penicillin is reviewed. These reactions, including a certain number of deaths which have been reported, are of particular interest to health administrations and to WHO in view of the large-scale programmes for controlling the treponematoses which are now under way—programmes affecting millions of people in many parts of the world. The most serious problems are anaphylactic sensitivity phenomena and superinfection or cross-infection with penicillin-resistant organisms, and the reactions involved range in intensity from the mildest to the fatal; the incidence of the latter is estimated at 0.1-0.3 per million injections. The authors point out that with increasing use of penicillin, more persons are likely to become sensitized and the number of reactions can therefore be expected to rise. The best prevention against such an increase is the restriction of the unnecessary use of penicillin. PMID:13596877

The Mercury Problem in Artisanal and Small‐Scale Gold Mining

PubMed Central

2018-01-01

Abstract Mercury‐dependent artisanal and small‐scale gold mining (ASGM) is the largest source of mercury pollution on Earth. In this practice, elemental mercury is used to extract gold from ore as an amalgam. The amalgam is typically isolated by hand and then heated—often with a torch or over a stove—to distill the mercury and isolate the gold. Mercury release from tailings and vaporized mercury exceed 1000 tonnes each year from ASGM. The health effects on the miners are dire, with inhaled mercury leading to neurological damage and other health issues. The communities near these mines are also affected due to mercury contamination of water and soil and subsequent accumulation in food staples, such as fish—a major source of dietary protein in many ASGM regions. The risks to children are also substantial, with mercury emissions from ASGM resulting in both physical and mental disabilities and compromised development. Between 10 and 19 million people use mercury to mine for gold in more than 70 countries, making mercury pollution from ASGM a global issue. With the Minamata Convention on Mercury entering force this year, there is political motivation to help overcome the problem of mercury in ASGM. In this effort, chemists can play a central role. Here, the problem of mercury in ASGM is reviewed with a discussion on how the chemistry community can contribute solutions. Introducing portable and low‐cost mercury sensors, inexpensive and scalable remediation technologies, novel methods to prevent mercury uptake in fish and food crops, and efficient and easy‐to‐use mercury‐free mining techniques are all ways in which the chemistry community can help. To meet these challenges, it is critical that new technologies or techniques are low‐cost and adaptable to the remote and under‐resourced areas in which ASGM is most common. The problem of mercury pollution in ASGM is inherently a chemistry problem. We therefore encourage the chemistry community to consider and address this issue that affects the health of millions of people. PMID:29314284

The Mercury Problem in Artisanal and Small-Scale Gold Mining.

PubMed

Esdaile, Louisa J; Chalker, Justin M

2018-05-11

Mercury-dependent artisanal and small-scale gold mining (ASGM) is the largest source of mercury pollution on Earth. In this practice, elemental mercury is used to extract gold from ore as an amalgam. The amalgam is typically isolated by hand and then heated-often with a torch or over a stove-to distill the mercury and isolate the gold. Mercury release from tailings and vaporized mercury exceed 1000 tonnes each year from ASGM. The health effects on the miners are dire, with inhaled mercury leading to neurological damage and other health issues. The communities near these mines are also affected due to mercury contamination of water and soil and subsequent accumulation in food staples, such as fish-a major source of dietary protein in many ASGM regions. The risks to children are also substantial, with mercury emissions from ASGM resulting in both physical and mental disabilities and compromised development. Between 10 and 19 million people use mercury to mine for gold in more than 70 countries, making mercury pollution from ASGM a global issue. With the Minamata Convention on Mercury entering force this year, there is political motivation to help overcome the problem of mercury in ASGM. In this effort, chemists can play a central role. Here, the problem of mercury in ASGM is reviewed with a discussion on how the chemistry community can contribute solutions. Introducing portable and low-cost mercury sensors, inexpensive and scalable remediation technologies, novel methods to prevent mercury uptake in fish and food crops, and efficient and easy-to-use mercury-free mining techniques are all ways in which the chemistry community can help. To meet these challenges, it is critical that new technologies or techniques are low-cost and adaptable to the remote and under-resourced areas in which ASGM is most common. The problem of mercury pollution in ASGM is inherently a chemistry problem. We therefore encourage the chemistry community to consider and address this issue that affects the health of millions of people. © 2018 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

Suicide in women

PubMed Central

Vijayakumar, Lakshmi

2015-01-01

Suicide is a global public health problem. Asia accounts for 60% of the world's suicides, so at least 60 million people are affected by suicide or attempted suicide in Asia each year. The burden of female suicidal behavior, in terms of total burden of morbidity and mortality combined, is more in women than in men. Women's greater vulnerability to suicidal behavior is likely to be due to gender related vulnerability to psychopathology and to psychosocial stressors. Suicide prevention programmes should incorporate woman specific strategies. More research on suicidal behavior in women particularly in developing countries is needed. PMID:26330640

Alcohol-Use Disorders in the Critically Ill Patient

PubMed Central

Jones, Drew G.; Sessler, Curtis N.; Zilberberg, Marya D.; Weaver, Michael F.

2010-01-01

Alcohol abuse and dependence, referred to as alcohol-use disorders (AUDs), affect 76.3 million people worldwide and account for 1.8 million deaths per year. AUDs affect 18.3 million Americans (7.3% of the population), and up to 40% of hospitalized patients have AUDs. This review discusses the development and progression of critical illness in patients with AUDs. In contrast to acute intoxication, AUDs have been linked to increased severity of illness in a number of studies. In particular, surgical patients with AUDs experience higher rates of postoperative hemorrhage, cardiac complications, sepsis, and need for repeat surgery. Outcomes from trauma are worse for patients with chronic alcohol abuse, whereas burn patients who are acutely intoxicated may not have worse outcomes. AUDs are linked to not only a higher likelihood of community-acquired pneumonia and sepsis but also a higher severity of illness and higher rates of nosocomial pneumonia and sepsis. The management of sedation in patients with AUDs may be particularly challenging because of the increased need for sedatives and opioids and the difficulty in diagnosing withdrawal syndrome. The health-care provider also must be watchful for the development of dangerous agitation and violence, as these problems are not uncommonly seen in hospital ICUs. Despite studies showing that up to 40% of hospitalized patients have AUDs, relatively few guidelines exist on the specific management of the critically ill patient with AUDs. AUDs are underdiagnosed, and a first step to improving patient outcomes may lie in systematically and accurately identifying AUDs. PMID:20923804

Spondylitis Association of America

MedlinePlus

... Spondyloarthritis affects more people than Multiple Sclerosis (MS), Rheumatoid Arthritis, and Autism, yet it remains relatively unknown. MS (400,000) Rheumatoid Arthritis (1.3million) Autism (1.5million) Spondyloarthritis (2.7million) ...

Kosi Floods 2008: Devastation, Displacement and Migration Experience

NASA Astrophysics Data System (ADS)

Kumar, Prashant; Ahlawat, Monica

2017-04-01

The massive Kosi River floods of August 2008 caused unprecedented loss to lives, livelihoods, infrastructure and property in north-eastern Bihar. The five flood-affected districts (Araria, Madhepura, Purnia, Saharsa and Supaul) are among the poorest districts in India. In 2011, during the last national Census, the total population of the five districts was about 11 million. About 1,000 villages in these five districts were affected and nearly three million people were displaced. Displaced people had to face various kinds of problems like lack of livelihood, loss of house and property, lack of health and hygiene etc. Posts flooding, because of constrained livelihood opportunities, depressed economy, and probability of future flooding event, many families have migrated to other parts of the country. This study was done to find out how displacement as well as migration has affected their lives, how they have coped with it, and what the government response to this disaster was. Both primary as well as secondary data have been used for this study. Secondary data was collected from government offices and websites, news articles and satellite images. Satellite images were used to detect the change in course of river and how much this change in course affected the displacement pattern. For this purpose the satellite images of affected area from an earlier time period and during the floods were taken and their impact was studied. Primary data has been collected through questionnaire and field survey and has been used to understand migration experience of affected population. With the help of these data, the paper analyses the 2008 Kosi flood as a socio-ecological regime shift and explains migration as a societal response to such a shift. Keywords: Floods, Displacement, Satellite Images, Socio-Ecological Regime Shift, Migration

Silvicultural Use of Wastewater Sludge

Treesearch

J.B. Hart; P.V. Nguyen; D.H. Urie; Dale G. Brockway

1988-01-01

Generation of wastewater sludge in the United States has become a problem of increasing proportion, with annual production at 4 million tons in 1970 (Walsh 1976) and 7 million tons currently(Maness 1987). While population and industrial growth have contributed to this problem, legislation requiring higher standards of treatment for wastewater processed in the 15,378...

A review of arsenic and its impacts in groundwater of the Ganges-Brahmaputra-Meghna delta, Bangladesh.

PubMed

Edmunds, W M; Ahmed, K M; Whitehead, P G

2015-06-01

Arsenic in drinking water is the single most important environmental issue facing Bangladesh; between 35 and 77 million of its 156 million inhabitants are considered to be at risk from drinking As-contaminated water. This dominates the list of stress factors affecting health, livelihoods and the ecosystem of the delta region. There is a vast literature on the subject so this review provides a filter of the more important information available on the topic. The arsenic problem arises from the move in the 1980s and 1990s by international agencies to construct tube wells as a source of water free of pathogens, groundwater usually considered a safe source. Since arsenic was not measured during routine chemical analysis and also is difficult to measure at low concentrations it was not until the late 1990s that the widespread natural anomaly of high arsenic was discovered and confirmed. The problem was exacerbated by the fact that the medical evidence of arsenicosis only appears slowly. The problem arises in delta regions because of the young age of the sediments deposited by the GBM river system. The sediments contain minerals such as biotite which undergo slow "diagenetic" reactions as the sediments become compacted, and which, under the reducing conditions of the groundwater, release in the form of toxic As(3+). The problem is restricted to sediments of Holocene age and groundwater of a certain depth (mainly 30-150 m), coinciding with the optimum well depth. The problem is most serious in a belt across southern Bangladesh, but within 50 m of the coast the problem is only minor because of use of deep groundwater; salinity in shallow groundwater here is the main issue for drinking water. The Government of Bangladesh adopted a National Arsenic Policy and Mitigation Action Plan in 2004 for providing arsenic safe water to all the exposed population, to provide medical care for those who have visible symptoms of arsenicosis. There is as yet no national monitoring program in place. Various mitigation strategies have been tested, but generally the numerous small scale technological remedies have proved unworkable at village level. The current statistics show that use of deep groundwater (below 150 m) is the main source of arsenic mitigation over most of the arsenic affected areas as well as rainwater harvesting in certain location.

Solutions of large-scale electromagnetics problems involving dielectric objects with the parallel multilevel fast multipole algorithm.

PubMed

Ergül, Özgür

2011-11-01

Fast and accurate solutions of large-scale electromagnetics problems involving homogeneous dielectric objects are considered. Problems are formulated with the electric and magnetic current combined-field integral equation and discretized with the Rao-Wilton-Glisson functions. Solutions are performed iteratively by using the multilevel fast multipole algorithm (MLFMA). For the solution of large-scale problems discretized with millions of unknowns, MLFMA is parallelized on distributed-memory architectures using a rigorous technique, namely, the hierarchical partitioning strategy. Efficiency and accuracy of the developed implementation are demonstrated on very large problems involving as many as 100 million unknowns.

Estimates of HIV burden in emergencies

PubMed Central

Lowicki-Zucca, M; Spiegel, P B; Kelly, S; Dehne, K-L; Walker, N; Ghys, P D

2008-01-01

Objective: To quantify the proportion of people living with HIV who are being affected by emergencies. Methods: Emergencies were defined as conflict, natural disaster and/or displacement. Country-specific estimates of populations affected by emergencies were developed based on eight publicly available databases and sources. These estimates were calculated as proportions and then combined with updated country-level HIV estimates for the years 2003, 2005 and 2006 to obtain estimates of the number of men, women and children living with HIV who were also affected by emergencies. Results: In 2006, 1.8 (range 1.3–2.5) million people living with HIV (PLHIV) were also affected by conflict, disaster or displacement, representing 5.4% (range 4.0–7.6%) of the global number of PLHIV. In the same year, an estimated 930 000 (range 660 000–1.3 million) women and 150 000 (range 110 000–230 000) children under 15 years living with HIV were affected by emergencies. In emergency settings, the estimated numbers of PLHIV in 2003 and 2005 were 2.6 million (range 2.0–3.4 million) and 1.7 million (range 1.4–2.1 million), respectively, representing 7.9% and 5.1% of the global number of PLHIV). Conclusions: These estimates provide a rationale to ensure that HIV interventions are integrated into rapid assessment of all emergency and preparedness and response plans to prevent HIV infections and address excess suffering, morbidity and mortality among these often overlooked vulnerable groups. PMID:18647865

Reproductive health, population growth, economic development and environmental change.

PubMed

Lincoln, D W

1993-01-01

World population will increase by 1000 million, or by 20%, within 10 years. Ninety-five per cent of this increase will occur in the South, in areas that are already economically, environmentally and politically fragile. Morbidity and mortality associated with reproduction will be greater in the current decade than in any period in human history. Annually, 40-60 million pregnancies will be terminated and 5-10 million children will die within one year of birth. AIDS-related infections, e.g. tuberculosis, will undermine health care in Africa (and elsewhere) and in places AIDS-related deaths will decimate the work-force. The growth in population and associated morbidity will inhibit global economic development and spawn new problems. The key issues are migration, the spread of disease, the supply of water and the degradation of land, and fiscal policies with respect to family planning, pharmaceuticals and Third-World debt. Full education, particularly of women, and more effective family planning in the South have the power to unlock the problem. Failure will see the developed countries, with their 800 million population, swamped by the health, economic and environmental problems of the South, with its projected population of 5400 million people for the year 2000.

Snakebite in bedroom kills a physician in Cameroon: a case report.

PubMed

Nkwescheu, Armand; Mbasso, Leopold Cyriaque Donfack; Pouth, Franky Baonga Ba; Dzudie, Anastase; Billong, Serge Clotaire; Ngouakam, Hermann; Diffo, Joseph Le Doux; Eyongorock, Hanny; Mbacham, Wilfred

2016-01-01

The World Health Organization (WHO) classifies snake bites as neglected public health problem affecting mostly tropical and subtropical countries. In Africa there are an estimated 1 million snake bites annually with about half needing a specific treatment. Women, children and farmers in poor rural communities in developing countries are the most affected. Case management of snake bites are not adequate in many health facilities in developing countries where personnel are not always abreast with the new developments in snake bite management and in addition, quite often the anti-venom serum is lacking. We report the case of a medical doctor bitten by a cobra in the rural area of Poli, Cameroon while asleep in his bedroom. Lack of facilities coupled with poor case management resulted in a fatal outcome.

Access to healthcare for children in Palestine.

PubMed

Waterston, Tony; Nasser, Dina

2017-01-01

Currently, 5 million Palestinian refugees live in Palestine, Jordan, Syria and Lebanon and around 40% of these are children. Mortality rates for Palestinian children are comparable to neighbouring Arab countries but the speed of reduction has faltered in recent years. Morbidity is greatly affected by the occupation which has increased violence towards children, mental health problems and poor nutrition, particularly in Gaza which is experiencing a health crisis. Access to healthcare for children in Palestine is constrained as a result of the requirement for visas to travel into Jerusalem where specialist hospitals are sited, by difficulties with ambulance transfers, by shortages of equipment in hospitals and by lack of trained staff. Palestinian health workers are developing new initiatives in healthcare and show a high level of resilience, despite the very considerable stress affecting most citizens.

Toxicodendron dermatitis: poison ivy, oak, and sumac.

PubMed

Gladman, Aaron C

2006-01-01

Allergic contact dermatitis caused by the Toxicodendron (formerly Rhus) species-poison ivy, poison oak, and poison sumac-affects millions of North Americans every year. In certain outdoor occupations, for example, agriculture and forestry, as well as among many outdoor enthusiasts, Toxicodendron dermatitis presents a significant hazard. This review considers the epidemiology, identification, immunochemistry, pathophysiology, clinical features, treatment, and prevention of this common dermatologic problem. Recent research in prevention is emphasized, and resources to help in the identification of plants are provided in the bibliography. The literature was searched using a MEDLINE query for "Toxicodendron dermatitis", and the identified article bibliographies were searched as well.

Lice update: new solutions to an old problem.

PubMed

Wadowski, Lisa; Balasuriya, Lily; Price, Harper N; O'Haver, Judith

2015-01-01

An estimated 6 to 12 million children are affected by lice annually in the United States.(1) Knowledge of the various treatment options for this diagnosis is essential. This paper aims to provide an overview of the myriad therapeutic options available for lice infestations in children. U.S. Food and Drug Administration-approved drugs, off-label drug therapies, over-the counter-products, and herbal remedies are all discussed in detail. Clinicians may use this information to teach patients and families about the latest available care for the eradication of head lice in pediatric patients. Copyright © 2015 Elsevier Inc. All rights reserved.

Trends in domestic violence service and leadership: implications for an integrated shelter model.

PubMed

Panzer, P G; Philip, M B; Hayward, R A

2000-05-01

Domestic violence is a dangerous and prevalent social problem affecting up to 4 million women and countless children annually. Shelters offer safety and an opportunity for change during the crisis of family violence. These individuals also have the potential for retraumatization if leadership within the program recapitulates the abuse and coercion felt at home. This article reviews three related trends through the lens of power and control--domestic violence policy and service, models of leadership, and the study of traumatic stress disorders and recovery--and describes their implications for modern shelter service delivery.

India: National Adult Education to Reach 310 Million Illiterates.

ERIC Educational Resources Information Center

Literacy Work, 1978

1978-01-01

India's national adult education program is being planned to bring literacy to its 310 million adult illiterates. The first stage is projected to cover 100 million persons in the 15-35 age group by 1983-84. Problems include motivating institutions and individuals to participate and providing for adequate funding. (MF)

Economic burden of torture for a refugee host country: development of a model and presentation of a country case study.

PubMed

Mpinga, Emmanuel Kabengele; Frey, Conrad; Chastonay, Philippe

2014-01-01

Torture is an important social and political problem worldwide that affects millions of people. Many host countries give victims of torture the status of refugee and take care of them as far as basic needs; health care, professional reinsertion, and education. Little is known about the costs of torture. However, this knowledge could serve as an additional argument for the prevention and social mobilization to fight against torture and to provide a powerful basis of advocacy for rehabilitation programs and judiciary claims. Development of a model for estimating the economic costs of torture and applying the model to a specific country. The estimation of the possible prevalence of victims of torture was based on a review of the literature. The identification of the socioeconomic factors to be considered was done by analogy with various health problems. The estimation of the loss of the productivity and of the economic burden of disease related to torture was done through the human capital approach and the component technique analysis. The model was applied to the situation in Switzerland of estimated torture victims Switzerland is confronted with. When applied to the case study, the direct costs - such as housing, food, and clothing - represent roughly 130 million Swiss francs (CHF) per year; whereas, health care costs amount to 16 million CHF per year, and the costs related to education of young people to 34 million CHF per year. Indirect costs, namely those costs related to the loss of the productivity of direct survivors of torture, have been estimated to one-third of 1 billion CHF per year. This jumps to 10,073,419,200 CHF in the loss of productivity if one would consider 30 years of loss per survivor. Our study shows that a rough estimation of the costs related to torture is possible with some prerequisites, such as access to social and economic indicators at the country level.

[Compilation of historical anecdotes about chronic wounds. Well-known people who have suffered from them].

PubMed

García Fernández, Francisco Pedro; López Casanova, Pablo; Pancorbo Hidalgo, Pedro Luis; Verdú Soriano, José

2009-01-01

Throughout the course of human history many people have been affected by the presence of chronic wounds. Millions of anonymous people have suffered bed sores, varicose ulcers, arterial ulcers or neuropathic ulcers. But there have been some famous people who, from time to time, remove these lesions from their cloak of invisibility In our day and age, every time a famous person suffers from these wounds, we observe how the means of communication publicize this health problem. However famous people also suffered from these wounds in the past. In this article, the authors will review historical figures who died due to these feared sores. Kings or saints have been affected by this problem. Specifically the authors will focus on six historical figures: three kings, one composer and two saints,; the authors shall analyze the influence of chronic wounds as a cause of their deaths. This article was submitted at the VII National Symposium on Bed Sores and Chronic Wounds and at the First Latin American Congress on Ulcers and Wounds.

Site Suitability Analysis for Dissemination of Salt-tolerant Rice Varieties in Southern Bangladesh

NASA Astrophysics Data System (ADS)

Sinha, D. D.; Singh, A. N.; Singh, U. S.

2014-11-01

Bangladesh is a country of 14.4 million ha geographical area and has a population density of more than 1100 persons per sq. km. Rice is the staple food crop, growing on about 72 % of the total cultivated land and continues to be the most important crop for food security of the country. A project "Sustainable Rice Seed Production and Delivery Systems for Southern Bangladesh" has been executed by the International Rice Research Institute (IRRI) in twenty southern districts of Bangladesh. These districts grow rice in about 2.9 million ha out of the country's total rice area of 11.3 million ha. The project aims at contributing to the Government of Bangladesh's efforts in improving national and household food security through enhanced and sustained productivity by using salinity-, submergence- and drought- tolerant and high yielding rice varieties. Out of the 20 project districts, 12 coastal districts are affected by the problem of soil salinity. The salt-affected area in Bangladesh has increased from about 0.83 million ha in 1973 to 1.02 million ha in 2000, and 1.05 million ha in 2009 due to the influence of cyclonic storms like "Sidr", "Laila" and others, leading to salt water intrusion in croplands. Three salinity-tolerant rice varieties have recently been bred by IRRI and field tested and released by the Bangladesh Rice Research Institute (BRRI) and Bangladesh Institute of Nuclear Agriculture (BINA). These varieties are BRRI dhan- 47 and Bina dhan-8 and - 10. However, they can tolerate soil salinity level up to EC 8-10 dSm-1, whereas the EC of soils in several areas are much higher. Therefore, a large scale dissemination of these varieties can be done only when a site suitability analysis of the area is carried out. The present study was taken up with the objective of preparing the site suitability of the salt-tolerant varieties for the salinity-affected districts of southern Bangladesh. Soil salinity map prepared by Soil Resources Development Institute of Bangladesh shows five classes of salinity. viz., non-saline with some very slight saline soil, very slightly saline with some slight saline soil, slightly saline with some moderately saline soil, strongly saline with some moderately saline soil, and very strongly saline with some strongly saline soil. The soil EC level of different classes range from 2 dSm-1 to >16 dSm-1. The soil map was geo-referenced and digitized using Arc GIS. Salinity tolerance characteristics of the rice varieties were matched with the soil characteristics shown on the map. Three suitability classes were made; soils suitable for salt-tolerant varieties, not suitable for salt-tolerant varieties due to high soil salinity, and suitable for other high yielding varieties due to slight salinity. The mauza (smallest revenue unit) boundary provided by the Bangladesh Agriculture Research Council was also geo-referenced and digitized in the same projection. Overlaying and intersecting the mauza boundary on the soil suitability map provided the suitable and not suitable mauza. A total of 4070 mauzas in the 12 salinity-affected districts were listed and maps showing suitability of mauza prepared. About 0.6 million ha out of total 0.87 million ha salinity affected area were found suitable for growing the salinity-tolerant BRRI dhan-47, Bina dhan-8 and -10 in these districts. The maps and other generated information have helped the Dept. of Agriculture Extension (DAE) of Bangladesh in large scale dissemination of seeds of the salinity-tolerant rice varieties in different districts during the past two years.

Respiratory disease and particulate air pollution in Santiago Chile: Contribution of erosion particles from fine sediments

Treesearch

Pablo A. Garcia-Chevesich; Sergio Alvarado; Daniel G. Neary; Rodrigo Valdes; Juan Valdes; Juan Jose Aguirre; Marcelo Mena; Roberto Pizarro; Paolo Jofre; Mauricio Vera; Claudio Olivares

2014-01-01

Air pollution in Santiago is a serious problem every winter, causing thousands of cases of breathing problems within the population. With more than 6 million people and almost two million vehicles, this large city receives rainfall only during winters. Depending on the frequency of storms, statistics show that every time it rains, air quality improves for a couple of...

The Magnitude of Medical Problems of the Elderly in the United States.

ERIC Educational Resources Information Center

Goldstein, Harold M.

1975-01-01

Medical problems of older Americans are described, based on the types of illnesses and their frequency among the elderly. Those 65 years of age and older are defined as elderly, placing 20 million of the 203 million Americans in this category (1970 census). The major causes of chronic conditions in the elderly and the percent of those 65-74 years…

History, epidemiology and diagnostics of dengue in the American and Brazilian contexts: a review.

PubMed

Salles, Tiago Souza; da Encarnação Sá-Guimarães, Thayane; de Alvarenga, Evelyn Seam Lima; Guimarães-Ribeiro, Victor; de Meneses, Marcelo Damião Ferreira; de Castro-Salles, Patricia Faria; Dos Santos, Carlucio Rocha; do Amaral Melo, Ana Claudia; Soares, Marcia Regina; Ferreira, Davis Fernandes; Moreira, Monica Ferreira

2018-04-24

Dengue virus (DENV), an arbovirus transmitted by mosquitoes, has become a major threat to American human life, reaching approximately 23 million cases from 1980 to 2017. Brazil is among the countries most affected by this terrible viral disease, with 13.6 million cases. DENV has four different serotypes, DENV1-4, which show a broad clinical spectrum. Dengue creates a staggering epidemiological and economic burden for endemic countries. Without a specific therapy and with a commercial vaccine that presents some problems relative to its full effectiveness, initiatives to improve vector control strategies, early disease diagnostics and the development of vaccines and antiviral drugs are priorities. In this study, we present the probable origins of dengue in America and the trajectories of its spread. Overall, dengue diagnostics are costly, making the monitoring of dengue epidemiology more difficult and affecting physicians' therapeutic decisions regarding dengue patients, especially in developing countries. This review also highlights some recent and important findings regarding dengue in Brazil and the Americas. We also summarize the existing DENV polymerase chain reaction (PCR) diagnostic tests to provide an improved reference since these tests are useful and accurate at discriminating DENV from other flaviviruses that co-circulate in the Americas. Additionally, these DENV PCR assays ensure virus serotyping, enabling epidemiologic monitoring.

Syphilis in children: congenital and acquired.

PubMed

Woods, Charles R

2005-10-01

Syphilis rates in women and congenital syphilis rates have declined steadily in the United States in recent years. However, syphilis remains a worldwide public health problem, with more than 12 million cases in adults and more than half a million pregnancies affected yearly. Prenatal screening and treatment programs are limited or nonexistent in many developing countries. The genome of Treponema pallidum, one of the smallest among prokaryotes, has been sequenced, but methods for continuous in vitro cultivation of the microbe remain elusive. There are no promising candidates for future vaccines at this time. Serologic testing, for both specific treponemal and nontreponemal antibodies, continues to be a primary means of diagnosis. Penicillin remains the drug of choice for congenital and acquired syphilis in childhood. The diagnosis of syphilis beyond early infancy raises concerns for possible child sexual abuse, although progression of congenital syphilis may account for some cases. Syphilis is a potentially eradicable disease, but this can be achieved only with sustained international will and cooperation to fund the necessary screening and treatment programs.

Mountains, Melting Pot, and Microcosm: Health Care Delay and Dengue/Zika Interplay on Hawaii Island.

PubMed

Baenziger, Nancy L

2016-11-01

Human history in the Hawaiian Islands offers a sobering study in the population dynamics of infectious disease. The indigenous population numbering an estimated half million people prior to Western contact in 1778 was reduced to less than 24,000 by 1920. Much of the decline occurred in the earliest decades after contact with Western diseases including measles, chicken pox, polio, tuberculosis, and venereal disease. A recent outbreak on the Island of Hawaii (also called the Big Island) of imported dengue fever, an illness endemic in 100 countries affecting an estimated 100-400 million people worldwide, provides insights into the problems and prospects for health care policy in managing mosquito-borne disease in a multicultural setting of geographic isolation and health care provider shortage. This incident represents in microcosm a practice run, applicable in many contexts, for an initial localized appearance of Zika virus infection, with important lessons for effective health care management in a rapidly moving and fluid arena.

Preparing the Pipeline: The U.S. Cyber Workforce for the Future

DTIC Science & Technology

2012-08-01

duty and Reserve military personnel. As a result, VA spent $7 million to notify affected per- sonnel of the data breach , $100 million to offer 1 year...of free credit reporting to affected individuals, and also faced a class-action lawsuit from five veterans’ groups.16 The data breach occurred

[Psychosocial aspects and accidents in land transport].

PubMed

Morales-Soto, Nelson; Alfaro-Basso, Daniel; Gálvez-Rivero, Wilfredo

2010-06-01

Road traffic accidents are a public health problem in Peru, having caused 35 596 deaths in Peru between 1998 and 2008. Lima is the most affected region, presenting 61.7% of the accidents, the annual cost reached one thousand million dollars, equivalent to a third part of the investment in health. Available studies give emphasis to the protagonists--the drivers, the pedestrians--or to equipment and roads; the laws have been modified and containment plans for accidents have been implemented, but the incidence remains the same. We raise the possibility of exploring behavioral and social factors that could be relevant in the genesis of the problem, revising those related to current disorder in transport, the behaviors of drivers and pedestrians and the permissiveness of society in general particularly of the authority. We propose research and a multidisciplinary and intersectoral intervention.

Comparative effectiveness and adverse effects of interferon alpha-2b plus ribavirin therapy in hepatitis 'C' for 26 weeks.

PubMed

Ali, Shafqut; Iram, Samia

2009-01-01

Hepatitis C is major emerging challenge for pathologists and treating physicians all over the world. Already 10 million Pakistani population has become anti-HCV positive. It is not only affecting hepatobiliary system but with passage of time research is revealing that Hepatitis C is going to involve almost every organ of the body. With timely diagnosis and treatment, millions of patients can be saved from morbidity and mortality. The nation has to sacrifice initial economic allocations to avoid later millions of mortalities and greater economic losses on affected patients and to support their families. The objective of this study was to evaluate effectiveness of combine therapy of Hepatitis C in local population of Pakistan. This case series study was done at CMH Okara, Kohat, Abbottabad, and PAF Hospital, Shorkot from August 2000 to August 2009. All 1,000 patients from 10 to 60 years of age, confirmed anti-HCV Positive by ELISA and PCR Positive for HCV RNA, were subjected to Interferon alpha-2b and Ribavirin therapy for similar period of time. Response and adverse affects were observed by clinical examination, blood complete picture including platelet count and ALT fortnightly. PCR for HCV RNA and ultrasound abdomen (hepatobilliary system) was done quarterly during treatment and 6 monthly for 2 years after treatment to review the sustained response and relapse. Over all cure rate after 2 years was 855 (85.5%) excluding the 50 (5%) of initial resistant to one year treatment and 95 (9.5%) re-treated relapse cases. One hundred and forty-five (14.5%) patients were found to be resistant to treatment. Hepatitis C must be treated timely after proper diagnosis. Interferon and Ribavirin combination have shown high 'cure' rate in Hepatitis C. In spite of high cure rate of 85.5% with timely and proper treatment, low socio-economic status is a major problem for poor individuals to get treatment. Preventive aspect must be strictly followed and implemented.

[LIGHT POLLUTION AS THE HYGIENIC PROBLEM].

PubMed

Kaptsov, V A; Gerasev, V F; Deynego, V N

2015-01-01

Mass introduction of lighting devices according to the concept of "maximum coverage area" and multistoried buildings of cities gave rise to light pollution, which became a problem for astronomers, ecologists and hygienists. Analysis of modern lighting devices and installations has shown that about 30-45% of the luminous flux becomes the light pollution. Night lighting of cities causes both direct and indirect damage to the environment, leads to unnecessary energy wastes. So in the USA due to excessive light there is wasted about 2 million barrels of oil per day. Light pollution affects the human hormonal system, causing various health disorders, such as insomnia and depression as a consequence. The light pollution through the ganglion cells of the retina affects the synthesis of melatonin by the pineal gland (epiphysis) and contributes to its calcification, which greatly affects the human psyche. At present, many countries have been paying much state attention to this problem via delivery of national documents and change of the concept of the designing of lighting devices and installations. The essence of this concept--to shine with a preset quality of light only in the right place at the specified time interval. This reduces the light pollution, saves energy and increases the environmental safety of lighting. There is presented an example of a technical solution to reduce the light pollution in the application of the light panel in the form of the gradient of the light guide generator project development.

[NURSING DIAGNOSIS PROPOSAL FOR GENDER VIOLENCE SYNDROME IN NANDA-I TAXONOMY].

PubMed

Antonio Flores, Juan; Almansa Martínez, María Pilar; Pina Roche, Florentina; Lozano Martínez, Myriam; Lucas Martínez, Ana María; Frapolli Gómez, Griselda

2015-03-01

Gender-based violence is a widespread and muted problem in public health that particularly affects millions of women worldwide. The situation being relegated to the private sphere is difficult to know the exact number of women who suffer and causes much of the morbidity and the mortality of women. However, at some point in their lives women visit health services and health professionals, especially nursing, is supposed to be the first to detect cases of abuse. The need to include gender-based violence as a nursing diagnosis is evident because nursing diagnoses names health problems which nurses can approach independently. We have conducted a literature search in order to propose violence as nursing diagnosis to NANDA-I, in order to recognize that this is really a serious health problem and that nursing has an important role in detecting and monitoring of women victims of violence. The aim of this paper is to describe the development phases of as a proposal for inclusion in the NANDA-I taxonomy.

Health problems in Iraq.

PubMed

Acheson, E D

1992-02-22

Iraq is faced with large scale public health problems that have been caused by the destruction to their infrastructure during the Gulf war. Humanitarian aid is needed in order to avoid a large scale human disaster. In 1988 73% of Iraq's population lived in urban areas. The loss of electrical generating capacity has affected hospitals, water purification and sewage treatment. Iraq had made great strides int he health of their people with an infant mortality rate of 42/1000 in 1990 and 52./1000 for children under 5. The international study team's survey of over 9000 households revealed surprising evidence of widespread chronic malnutrition. Based on accepted mortality as a baseline, data suggests that mortality among Iraqi infants and children under 5 doubled in 1991. The current food ration provides only half of the energy requirement and with rapidly accelerating inflation, the cost of food while only make the situation worse. The UN Disaster Relief Office has received $1.059 billion from donor countries; but, only half of the requested $14 million has been funded through Unicef. This money is needed to meet basic requirements for water, sanitation, antibiotics, and vaccines. The UN Security Council approved resolutions 706 and 712 which would have allowed Iraq to sell $1.6 billion for foodstuffs, medicines, and materials and supplies necessary to civilian needs subject to monitoring and supervision to ensure equitable distribution. The Iraqi government has not met the requirements of 706 and 712 because of the monitoring conditions, so no money has been issued. More money is needed if humanitarian organizations are to do their work. Only $29 million of the $145 million needed for the 1st half of this year has been pledged.

Outpatient drug oversupply at a teaching hospital in Thailand.

PubMed

Kaojarern, Sming; Ongphiphadhanakul, Boonsong; Pattanaprateep, Oraluck

2011-09-01

A part of rising drug expenditure in Thailand was causedfrom drug oversupply, which was a result from policy of civil servants to get direct reimbursement from Ministry ofFinance. Describe the problem oforal drug oversupply at outpatient service in a teaching hospital and determine the cost that affects hospital between October 1, 2008 and September 30, 2009. Data of oral drug prescribing for outpatients were retrievedfrom the hospital database in the format of Microsoft Visual Fox Pro 9.0 and analyzed by Microsoft Access 2007. Two assessment methods are applied to estimate drug oversupply more than 30 days, by month and by year. In addition, September 2009 was selected to study for a pattern of monthly drug oversupply. Total oversupply expenditure for fiscal year 2009 was 56.9 million Baht when summedfrom monthly basis and 62.0 million when performed as a whole year. Oversupply expenditure was 2.12 to 2.73%per month in term of money and 2.91 to 3.46% in term of quantity. In September 2009, cardiovascular & hematopoietic system had the most oversupply. By brand of drug, the most frequently oversupply were Calcium carbonate (7.60%), Simvastatin (3.69%) and Omeprazole (3.20%). In term of money, the top three highest costs were for Atorvastatin (7.27%), Clopidogrel (6.83%) and Rosuvastatin (4.24%). By health schemes, patients under CSMBS trend to be the most of prescribed drug oversupply at 8.31% (3.21 million Baht in September 2009) with average number of oversupply per patient at 1.83 items and average day left per drug item at 61.83 days. The most oversupply expenditures were for chronic diseases. These data will focus the problem for hospital administrators to plan for suitable strategy to control drug oversupply in their hospital.

Access to healthcare for children in Palestine

PubMed Central

Waterston, Tony; Nasser, Dina

2017-01-01

Currently, 5 million Palestinian refugees live in Palestine, Jordan, Syria and Lebanon and around 40% of these are children. Mortality rates for Palestinian children are comparable to neighbouring Arab countries but the speed of reduction has faltered in recent years. Morbidity is greatly affected by the occupation which has increased violence towards children, mental health problems and poor nutrition, particularly in Gaza which is experiencing a health crisis. Access to healthcare for children in Palestine is constrained as a result of the requirement for visas to travel into Jerusalem where specialist hospitals are sited, by difficulties with ambulance transfers, by shortages of equipment in hospitals and by lack of trained staff. Palestinian health workers are developing new initiatives in healthcare and show a high level of resilience, despite the very considerable stress affecting most citizens. PMID:29637139

Some Population Trends Affecting Extension Education and Other Community Programs.

ERIC Educational Resources Information Center

Niederfrank, E. J.

Population trends affecting extension education and other community programs reveal that there will be large increases in numbers of young adult and young middleaged households, beginning in the next five years. The number of households in the United States will rise to 84.4 million by July 1985, representing an increase of 26.3 million over the…

Preparing the Pipeline: The U.S. Cyber Workforce for the Future (Defense Horizons, Number 72)

DTIC Science & Technology

2012-08-01

duty and Reserve military personnel. As a result, VA spent $7 million to notify affected per- sonnel of the data breach , $100 million to offer 1 year...of free credit reporting to affected individuals, and also faced a class-action lawsuit from five veterans’ groups.16 The data breach occurred

Extensive arsenic contamination in high-pH unconfined aquifers in the Indus Valley

PubMed Central

Podgorski, Joel E.; Eqani, Syed Ali Musstjab Akber Shah; Khanam, Tasawar; Ullah, Rizwan; Shen, Heqing; Berg, Michael

2017-01-01

Arsenic-contaminated aquifers are currently estimated to affect ~150 million people around the world. However, the full extent of the problem remains elusive. This is also the case in Pakistan, where previous studies focused on isolated areas. Using a new data set of nearly 1200 groundwater quality samples throughout Pakistan, we have created state-of-the-art hazard and risk maps of arsenic-contaminated groundwater for thresholds of 10 and 50 μg/liter. Logistic regression analysis was used with 1000 iterations, where surface slope, geology, and soil parameters were major predictor variables. The hazard model indicates that much of the Indus Plain is likely to have elevated arsenic concentrations, although the rest of the country is mostly safe. Unlike other arsenic-contaminated areas of Asia, the arsenic release process in the arid Indus Plain appears to be dominated by elevated-pH dissolution, resulting from alkaline topsoil and extensive irrigation of unconfined aquifers, although pockets of reductive dissolution are also present. We estimate that approximately 50 million to 60 million people use groundwater within the area at risk, with hot spots around Lahore and Hyderabad. This number is alarmingly high and demonstrates the urgent need for verification and testing of all drinking water wells in the Indus Plain, followed by appropriate mitigation measures. PMID:28845451

African trypanosomiasis with special reference to Egyptian Trypanosoma evansi: is it a neglected zoonosis?

PubMed

El-Bahnasawy, Mamdouh M M; Khater, Mai Kh A; Morsy, Tosson A

2014-12-01

Trypanosomes (including humans) are blood and sometimes tissue parasites of the order Kinetoplastida, family Trypanosomatidae, genus Trypanosoma, principally transmitted by biting insects where most of them undergo a biological cycle. They are divided into Stercoraria with the posterior station inoculation, including T. cruzi, both an extra- and intracellular parasite that causes Chagas disease, a major human disease affecting 15 million people and threatening 100 million people in Latin America, and the Salivaria with the anterior station inoculation, mainly African livestock pathogenic trypanosomes, including the agents of sleeping sickness, a major human disease affecting around half a million people and threatening 60 million people in Africa. Now, T. evansi was reported in man is it required to investigate its zoonotic potential?

Treatment and prevention of malnutrition in Latin America: focus on Chile and Bolivia.

PubMed

Weisstaub, Gerardo; Aguilar, Ana Maria; Uauy, Ricardo

2014-06-01

Seven million children under 5 years of age died worldwide in 2011, and one-third had malnutrition. Latin America and Caribbean countries stand out for the notable improvement of their health and nutrition situation, particularly in pregnant women and young children. Nutrition-sensitive interventions such as promoting food security, women's empowerment, social safety nets, clean water, and sanitation, among others, are critical for success. In Bolivia, the program Desnutrición Cero (Malnutrition Zero) was able to reduce mortality from severe malnutrition after 5 years from 25% to less than 5%, based on widespread implementation of the World Health Organization 10-steps protocol for hospitalized care and the application of community management. The Economic Commission for Latin America estimated the cost of malnutrition for Costa Rica, El Salvador, Guatemala, Honduras, Nicaragua, Panama, and the Dominican Republic as US $6,658 million. Approximately 1 million children have dropped out of school because of malnutrition, and as a result, malnourished children have 2 years less schooling, which brings social and economic losses not only to those affected but to society at large. National and international nutrition and food programs developed over the past 50 years have been implemented as integral components of broader strategies of primary healthcare and education, oriented toward preventing deaths and improving the quality of life of low-socioeconomic-status groups. Treating hundreds or thousands of affected children will not solve the global public health problem of malnutrition. Access to adequate amounts of quality foods represents a basic human right and is a necessary precondition for health. In turn, good nutrition and health are prerequisites for human, social, and economic development.

Maternal and child undernutrition and overweight in low-income and middle-income countries.

PubMed

Black, Robert E; Victora, Cesar G; Walker, Susan P; Bhutta, Zulfiqar A; Christian, Parul; de Onis, Mercedes; Ezzati, Majid; Grantham-McGregor, Sally; Katz, Joanne; Martorell, Reynaldo; Uauy, Ricardo

2013-08-03

Maternal and child malnutrition in low-income and middle-income countries encompasses both undernutrition and a growing problem with overweight and obesity. Low body-mass index, indicative of maternal undernutrition, has declined somewhat in the past two decades but continues to be prevalent in Asia and Africa. Prevalence of maternal overweight has had a steady increase since 1980 and exceeds that of underweight in all regions. Prevalence of stunting of linear growth of children younger than 5 years has decreased during the past two decades, but is higher in south Asia and sub-Saharan Africa than elsewhere and globally affected at least 165 million children in 2011; wasting affected at least 52 million children. Deficiencies of vitamin A and zinc result in deaths; deficiencies of iodine and iron, together with stunting, can contribute to children not reaching their developmental potential. Maternal undernutrition contributes to fetal growth restriction, which increases the risk of neonatal deaths and, for survivors, of stunting by 2 years of age. Suboptimum breastfeeding results in an increased risk for mortality in the first 2 years of life. We estimate that undernutrition in the aggregate--including fetal growth restriction, stunting, wasting, and deficiencies of vitamin A and zinc along with suboptimum breastfeeding--is a cause of 3·1 million child deaths annually or 45% of all child deaths in 2011. Maternal overweight and obesity result in increased maternal morbidity and infant mortality. Childhood overweight is becoming an increasingly important contributor to adult obesity, diabetes, and non-communicable diseases. The high present and future disease burden caused by malnutrition in women of reproductive age, pregnancy, and children in the first 2 years of life should lead to interventions focused on these groups. Copyright © 2013 Elsevier Ltd. All rights reserved.

Should Canadian health promoters support a food stamp-style program to address food insecurity?

PubMed

Power, Elaine M; Little, Margaret H; Collins, Patricia A

2015-03-01

Food insecurity is an urgent public health problem in Canada, affecting 4 million Canadians in 2012, including 1.15 million children, and associated with significant health concerns. With little political will to address this significant policy issue, it has been suggested that perhaps it is time for Canada to try a food stamp-style program. Such a program could reduce rates of food insecurity and improve the nutritional health of low-income Canadians. In this article, we explore the history of the US food stamp program; the key impetus of which was to support farmers and agricultural interests, not to look after the needs of people living in poverty. Though the US program has moved away from its roots, its history has had a lasting legacy, cementing an understanding of the problem as one of lack of food, not lack of income. While the contemporary food stamp program, now called Supplemental Nutrition Assistance Program (SNAP), reduces rates of poverty and food insecurity, food insecurity rates in the USA are significantly higher than those in Canada, suggesting a food stamp-style program per se will not eliminate the problem of food insecurity. Moreover, a food stamp-style program is inherently paternalistic and would create harm by reducing the autonomy of participants and generating stigma, which in itself has adverse health effects. Consequently, it is ethically problematic for health promoters to advocate for such a program, even if it could improve diet quality. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

29 CFR 779.267 - Fluctuations in annual gross volume affecting enterprise coverage and establishment exemptions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Act on the basis of previous sales analyses may fall below $1 million when the annual gross volume is... basis of previous sales analyses, may increase its annual gross volume to $1 million or more when... 29 Labor 3 2010-07-01 2010-07-01 false Fluctuations in annual gross volume affecting enterprise...

Annual Review of Progress in Applied Computational Electromagnetics (6th), Held in Monterey, California on March 19-22, 1990

DTIC Science & Technology

1990-01-01

the six fields will have two million cell locations. The table below shows the total allocation of 392 chips across fields and banks. To allow for...future growth, we allocate 16 wires for addressing both the rows and columns. eU 4 MBit locations bytes bits Chips (millions) (millions) (millions) per...sources apt to appear in most problems. If material parameters change during a run, then time must be allocated to read these constants into their

Choosing experiments to accelerate collective discovery

PubMed Central

Rzhetsky, Andrey; Foster, Jacob G.; Foster, Ian T.

2015-01-01

A scientist’s choice of research problem affects his or her personal career trajectory. Scientists’ combined choices affect the direction and efficiency of scientific discovery as a whole. In this paper, we infer preferences that shape problem selection from patterns of published findings and then quantify their efficiency. We represent research problems as links between scientific entities in a knowledge network. We then build a generative model of discovery informed by qualitative research on scientific problem selection. We map salient features from this literature to key network properties: an entity’s importance corresponds to its degree centrality, and a problem’s difficulty corresponds to the network distance it spans. Drawing on millions of papers and patents published over 30 years, we use this model to infer the typical research strategy used to explore chemical relationships in biomedicine. This strategy generates conservative research choices focused on building up knowledge around important molecules. These choices become more conservative over time. The observed strategy is efficient for initial exploration of the network and supports scientific careers that require steady output, but is inefficient for science as a whole. Through supercomputer experiments on a sample of the network, we study thousands of alternatives and identify strategies much more efficient at exploring mature knowledge networks. We find that increased risk-taking and the publication of experimental failures would substantially improve the speed of discovery. We consider institutional shifts in grant making, evaluation, and publication that would help realize these efficiencies. PMID:26554009

Nanotechnology for treating osteoporotic vertebral fractures

PubMed Central

Gao, Chunxia; Wei, Donglei; Yang, Huilin; Chen, Tao; Yang, Lei

2015-01-01

Osteoporosis is a serious public health problem affecting hundreds of millions of aged people worldwide, with severe consequences including vertebral fractures that are associated with significant morbidity and mortality. To augment or treat osteoporotic vertebral fractures, a number of surgical approaches including minimally invasive vertebroplasty and kyphoplasty have been developed. However, these approaches face problems and difficulties with efficacy and long-term stability. Recent advances and progress in nanotechnology are opening up new opportunities to improve the surgical procedures for treating osteoporotic vertebral fractures. This article reviews the improvements enabled by new nanomaterials and focuses on new injectable biomaterials like bone cements and surgical instruments for treating vertebral fractures. This article also provides an introduction to osteoporotic vertebral fractures and current clinical treatments, along with the rationale and efficacy of utilizing nanomaterials to modify and improve biomaterials or instruments. In addition, perspectives on future trends with injectable bone cements and surgical instruments enhanced by nanotechnology are provided. PMID:26316746

Erosion in the Healthcare Safety Net: Impacts on Different Population Groups.

PubMed

Mobley, Lee; Kuo, Tzy-Mey; Bazzoli, Gloria J

2011-03-30

Safety net hospitals (SNHs) have played a critical role in the U.S. health system providing access to health care for vulnerable populations, in particular the Medicaid and uninsured populations. However, little research has examined how access for these populations changes when contraction of the safety net occurs. Institutional policies, such as hospital closure or ownership conversion, could affect the supply of minority health care providers, thus exacerbating disparities in outcomes. We use multilevel logistic modeling of person-level hospital discharge data to examine the effects of contractions in the California safety net over the period of 1990-2000 on access to care as measured by changes in ambulatory care sensitive condition (ACSC) admissions, using geographic methods to characterize proximity to a contraction event. We found that presence of a contraction event was associated with a statistically significant increase in the predicted probability of impeded access, with an increase of about 1% for Medicaid-insured populations and about 4-5% for the uninsured. The Medicaid-insured group also maintained the highest rates of ACSC admissions over time, suggesting persistent access problems for this vulnerable group. This research is timely given continued budget problems in many states, where rising unemployment has increased the number of Medicaid enrollees by 6 million and uninsured individuals by 1.5 million, increasing pressure on remaining SNHs.

Erosion in the Healthcare Safety Net: Impacts on Different Population Groups

PubMed Central

Mobley, Lee; Kuo, Tzy-Mey; Bazzoli, Gloria J.

2011-01-01

Safety net hospitals (SNHs) have played a critical role in the U.S. health system providing access to health care for vulnerable populations, in particular the Medicaid and uninsured populations. However, little research has examined how access for these populations changes when contraction of the safety net occurs. Institutional policies, such as hospital closure or ownership conversion, could affect the supply of minority health care providers, thus exacerbating disparities in outcomes. We use multilevel logistic modeling of person-level hospital discharge data to examine the effects of contractions in the California safety net over the period of 1990–2000 on access to care as measured by changes in ambulatory care sensitive condition (ACSC) admissions, using geographic methods to characterize proximity to a contraction event. We found that presence of a contraction event was associated with a statistically significant increase in the predicted probability of impeded access, with an increase of about 1% for Medicaid-insured populations and about 4–5% for the uninsured. The Medicaid-insured group also maintained the highest rates of ACSC admissions over time, suggesting persistent access problems for this vulnerable group. This research is timely given continued budget problems in many states, where rising unemployment has increased the number of Medicaid enrollees by 6 million and uninsured individuals by 1.5 million, increasing pressure on remaining SNHs. PMID:21892377

Progress in understanding bark beetle effects on fire behavior using physics-based models

Treesearch

Chad M. Hoffman; Carolyn H. Sieg; Penelope Morgan; William Ruddy Mell; Rodman Linn; Camille Stevens-Rumann; Joel McMillin; Russell Parsons; Helen Maffei

2013-01-01

Bark beetle outbreaks are a major disturbance of forests throughout western North America affecting ecological processes and social and economic values (Amman 1977, Bond and Keeley 2005). Since the 1990s, bark beetle outbreaks have affected between 1.1 and 13.5 million acres in the western United States and an additional 13.5 million acres in British Columbia (Meddens...

Ten-year Survival and Its Associated Factors in the Patients Undergoing Pacemaker Implantation in Hospitals Affiliated to Shiraz University of Medical Sciences During 2002 - 2012

PubMed Central

Rajaeefard, Abdolreza; Ghorbani, Mohammad; Babaee Baigi, Mohammad Ali; Tabatabae, Hamidreza

2015-01-01

Background: Heart failure is a prevalent disease affecting about 4.9 million people in the U.S. and more than 22 million individuals worldwide. Using electric pacemaker is the most common treatment for the patients with heart conduction problems. The present study aimed to determine the factors affecting survival in the patients undergoing pacemaker implantation in the hospitals affiliated to Shiraz University of Medical Sciences. Objectives: The aim of the present study was to identify the factors affecting the survival of the patients suffering from arrhythmia. Patients and Methods: This retrospective survival analysis was conducted on all 1207 patients with heart failure who had undergone permanent pacemaker implantation in the hospitals affiliated to Shiraz University of Medical Sciences from 2002 to 2012. The data were analyzed using non-parametric methods such as Kaplan-Meier method, life table, and Cox regression model. The risk factors of mortality were determined using multivariate Cox proportional hazards method. Results: Survival data were available for 1030 (80%) patients (median age = 71 years [5th to 95th percentile range: 26 - 86 years]) and follow-up was completed for 84.28% of them. According to the results, 56% of the patients had received dual-chamber systems, while 44% had been implanted by single-chamber ventricular systems. Moreover, sick sinus syndrome and pacemaker mode were independent predictors of increased mortality. Conclusions: In this study, sick sinus syndrome and pacemaker mode followed by syncope were independently associated with increased mortality. PMID:26734484

State of the art on food allergen immunotherapy: oral, sublingual, and epicutaneous.

PubMed

Jones, Stacie M; Burks, A Wesley; Dupont, Christophe

2014-02-01

IgE-mediated food allergy is a global health problem that affects millions of persons and affects every aspect of life for the patient. Developing effective treatment strategies to augment current practice standards of strict dietary avoidance of antigens and availability of self-injectable epinephrine has been a major focus of research teams, advocacy groups, funding agencies, and patients and their families. Significant progress has been made through the development of allergen-specific immunotherapy encompassing 3 major forms of treatment: oral, sublingual, and epicutaneous immunotherapy. These therapies are in various stages of clinical investigation, with some successes noted in clinical outcomes and modulation of immune mechanisms toward effective therapy. Here we review recent progress and areas of concern for the role of these forms of immunotherapy as an emerging treatment for food allergy. Copyright © 2014 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.

Antidepressant Flavonoids and Their Relationship with Oxidative Stress

PubMed Central

Hritcu, Lucian; Ionita, Radu; Postu, Paula Alexandra; Gupta, Girish Kumar; Turkez, Hasan; Lima, Tamires Cardoso; Carvalho, Caroline Uchôa Souza

2017-01-01

Depression is a serious disorder that affects hundreds of millions of people around the world and causes poor quality of life, problem behaviors, and limitations in activities of daily living. Therefore, the search for new therapeutic options is of high interest and growth. Research on the relationship between depression and oxidative stress has shown important biochemical aspects in the development of this disease. Flavonoids are a class of natural products that exhibit several pharmacological properties, including antidepressant-like activity, and affects various physiological and biochemical functions in the body. Studies show the clinical potential of antioxidant flavonoids in treating depressive disorders and strongly suggest that these natural products are interesting prototype compounds in the study of new antidepressant drugs. So, this review will summarize the chemical and pharmacological perspectives related to the discovery of flavonoids with antidepressant activity. The mechanisms of action of these compounds are also discussed, including their actions on oxidative stress relating to depression. PMID:29410733

Less money, more problems: How changes in disposable income affect child maltreatment.

PubMed

McLaughlin, Michael

2017-05-01

A number of research studies have documented an association between child maltreatment and family income. Yet, little is known about the specific types of economic shocks that affect child maltreatment rates. The paucity of information is troubling given that more than six million children are reported for maltreatment annually in the U.S. alone. This study examines whether an exogenous shock to families' disposable income, a change in the price of gasoline, predicts changes in child maltreatment. The findings of a fixed-effects regression show that increases in state-level gas prices are associated with increases in state-level child maltreatment referral rates, even after controlling for demographic and other economic variables. The results are robust to the manner of estimation; random-effects and mixed-effects regressions produce similar estimates. The findings suggest that fluctuations in the price of gas may have important consequences for children. Copyright © 2017 Elsevier Ltd. All rights reserved.

Delivering golden rice to developing countries.

PubMed

Mayer, Jorge E

2007-01-01

Micronutrient deficiencies create a vicious circle of malnutrition, poverty, and economic dependency that we must strive to break. Golden Rice offers a sustainable solution to reduce the prevalence of vitamin A deficiency-related diseases and mortality, a problem that affects the health of millions of children in all developing countries. The technology is based on the reconstitution of the carotenoid biosynthetic pathway by addition of 2 transgenes. The outcome of this high-tech approach will be provided to end users as nutrient-dense rice varieties that are agronomically identical to their own, locally adapted varieties. This intervention has the potential to reach remote rural populations without access to fortification and supplementation programs. As part of our delivery strategy, we are partnering with government and nongovernment, national and international agricultural institutions to navigate through cumbersome and expensive regulatory regimes that affect the release of genetically modified crops, and to create local demand for the biofortified rice varieties.

Prevalence and effects of multiple chemical sensitivities in Australia.

PubMed

Steinemann, Anne

2018-06-01

Multiple chemical sensitivities (MCS) is a medical condition associated with exposure to common chemical pollutants. The aims of this study are to assess the prevalence of MCS, its overlaps with asthma and fragrance sensitivity, and its health and societal effects in Australia. Data were collected in June 2016 using an on-line survey with a representative national sample (N = 1098) of adults (ages 18-65) in Australia. Results found that, across the country, 6.5% report medically diagnosed MCS, 18.9% report chemical sensitivity (being unusually sensitive to everyday chemicals and chemically formulated products), and 19.9% either or both. Among people with MCS, 74.6% also have diagnosed asthma or an asthma-like condition, and 91.5% have fragrance sensitivity, reporting health problems (such as migraine headaches) when exposed to fragranced consumer products (such as air fresheners and cleaning supplies). In addition, among people with MCS, 77.5% are prevented from access to places because of fragranced products, 52.1% lost workdays or a job in the past year due to fragranced product exposure in the workplace, and 55.4% report health effects considered potentially disabling. Results indicate that MCS is a widespread disease, affecting an estimated 1 million adult Australians, with chemical sensitivity affecting another 2 million. Reducing chemical exposure to problematic sources, such as fragranced consumer products, is critical to reduce adverse effects.

Student Veteran perceptions of facilitators and barriers to achieving academic goals.

PubMed

Norman, Sonya B; Rosen, Jay; Himmerich, Sara; Myers, Ursula S; Davis, Brittany; Browne, Kendall C; Piland, Neill

2015-01-01

According to recent estimates, over 1 million Operation Iraqi Freedom/Operation Enduring Freedom (OIF/OEF) Veterans are utilizing the post-9/11 GI Bill to pursue higher education. Data collected by the Department of Defense suggests that greater than 17% of returning Veterans may suffer from mental and physical health disorders, which can negatively affect school performance. The current study explored student Veterans' perceived facilitators and barriers to achieving academic goals. Thirty-one student Veterans completed self-report measures and interviews. Results suggested that Veterans that were reporting problems or symptoms in one mental or physical health domain were likely to be reporting symptoms or problems in others as well. The interview data were coded, and three overarching themes related to barriers and facilitators emerged: person features (e.g., discipline and determination, symptoms and stressors), institutional structure (i.e., what schools and the Department of Veterans Affairs do that was perceived to help or hinder student Veteran success), and policy concerns (i.e., how the structure of the GI Bill affects student Veteran school experience). Results from this research indicate the need for larger studies and program development efforts aimed at enhancing academic outcomes for Veterans.

Number of People Blind or Visually Impaired by Cataract Worldwide and in World Regions, 1990 to 2010.

PubMed

Khairallah, Moncef; Kahloun, Rim; Bourne, Rupert; Limburg, Hans; Flaxman, Seth R; Jonas, Jost B; Keeffe, Jill; Leasher, Janet; Naidoo, Kovin; Pesudovs, Konrad; Price, Holly; White, Richard A; Wong, Tien Y; Resnikoff, Serge; Taylor, Hugh R

2015-10-01

To estimate prevalence and number of people visually impaired or blind due to cataract. Based on the Global Burden of Diseases Study 2010 and ongoing literature research, we examined how many people were affected by moderate to severe vision impairment (MSVI; presenting visual acuity <6/18, ≥3/60) and blindness (presenting visual acuity <3/60) due to cataract. In 2010, of overall 32.4 million blind and 191 million vision impaired, 10.8 million people were blind and 35.1 million were visually impaired due to cataract. Cataract caused worldwide 33.4% of all blindness in 2010, and 18.4% of all MSVI. These figures were lower in the high-income regions (<15%) and higher (>40%) in South and Southeast Asia and Oceania. From 1990 to 2010, the number of blind or visually impaired due to cataract decreased by 11.4% and by 20.2%, respectively; the age-standardized global prevalence of cataract-related blindness and MSVI reduced by 46% and 50%, respectively, and the worldwide crude prevalence of cataract-related blindness and MSVI reduced by 32% and 39%, respectively. The percentage of global blindness and MSVI caused by cataract decreased from 38.6% to 33.4%, and from 25.6% to 18.4%, respectively. This decrease took place in almost all world regions, except East Sub-Saharan Africa. In 2010, one in three blind people was blind due to cataract, and one of six visually impaired people was visually impaired due to cataract. Despite major improvements in terms of reduction of prevalence, cataract remains a major public health problem.

Progressive forest canopy water loss during the 2012-2015 California drought.

PubMed

Asner, Gregory P; Brodrick, Philip G; Anderson, Christopher B; Vaughn, Nicholas; Knapp, David E; Martin, Roberta E

2016-01-12

The 2012-2015 drought has left California with severely reduced snowpack, soil moisture, ground water, and reservoir stocks, but the impact of this estimated millennial-scale event on forest health is unknown. We used airborne laser-guided spectroscopy and satellite-based models to assess losses in canopy water content of California's forests between 2011 and 2015. Approximately 10.6 million ha of forest containing up to 888 million large trees experienced measurable loss in canopy water content during this drought period. Severe canopy water losses of greater than 30% occurred over 1 million ha, affecting up to 58 million large trees. Our measurements exclude forests affected by fire between 2011 and 2015. If drought conditions continue or reoccur, even with temporary reprieves such as El Niño, we predict substantial future forest change.

Proteolytic Regulation of the Intestinal Epithelial Barrier: Mechanisms and Interventions

DTIC Science & Technology

2013-09-01

gastrointestinal tract. The two main forms of inflammatory bowel diseases, Crohn’s disease and Ulcerative Colitis , currently affect over 1 million Americans...gastrointestinal tract. The two main forms of IBD, Crohn’s disease and Ulcerative Colitis , currently affect over 1 million Americans including military personnel...apoptosis and barrier disruption. IL-13 production and claudin-2 expression are both increased in human ulcerative colitis and Crohn’s disease (14; 15

Harms of cervical cancer screening in the United States and the Netherlands.

PubMed

Habbema, Dik; Weinmann, Sheila; Arbyn, Marc; Kamineni, Aruna; Williams, Andrew E; M C M de Kok, Inge; van Kemenade, Folkert; Field, Terry S; van Rosmalen, Joost; Brown, Martin L

2017-03-01

We studied harms related to cervical cancer screening and management of screen-positive women in the United States (US) and the Netherlands. We utilized data from four US integrated health care systems (SEARCH), the US National Health Interview Survey, New Mexico state, the Netherlands national histopathology registry, and included studies on adverse health effects of cervical screening. We compared the number of Papanicolaou (Pap) smear tests, abnormal test results, punch biopsies, treatments, health problems (anxiety, pain, bleeding and discharge) and preterm births associated with excisional treatments. Results were age-standardized to the 2007 US population. Based on SEARCH, an estimated 36 million Pap tests were performed in 2007 for 91 million US women aged 21-65 years, leading to 2.3 million abnormal Pap tests, 1.5 million punch biopsies, 0.3 million treatments for precancerous lesions, 5 thousand preterm births and over 8 million health problems. Under the Netherlands screening practice, fewer Pap tests (58%), abnormal test results (64%), punch biopsies (75%), treatment procedures (40%), preterm births (60%) and health problems (63%) would have occurred. The SEARCH data did not differ much from other US data for 2007 or from more recent data up to 2013. Thus compared to the less intensive screening practice in the Netherlands, US practice of cervical cancer screening may have resulted in two- to threefold higher harms, while the effects on cervical cancer incidence and mortality are similar. The results are also of high relevance in making recommendations for HPV screening. Systematic collection of harms data is needed for monitoring and for better incorporation of harms in making screening recommendations. © 2016 UICC.

Pacific Northwest Storms Situation Report # 3

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2006-12-17

Significant progress has been made in restoring power to customers in the Pacific Northwest region. Currently, 468,200 customers, including Canada, remain without power. This is down from 1.8 million customers who lost power following severe wind and snow storms on December 14-15, 2006. The customers without power represent about 16 percent of customers in the affected utility service areas of Oregon and Washington. See table below. The Olympic pipeline reports that the pipeline is operational; however, pipeline throughput remains reduced since one substation along the line remains without power. Complete power restoration is expected later today. There are no reportsmore » of problems regarding fuel distribution and production.« less

Type 2 diabetes and disease management: exploring the connections.

PubMed

Segal, Karen R

2004-01-01

Type 2 diabetes is an enormous public health problem affecting an estimated 18.2 million Americans. The prevalence is increasing, particularly among youth and young adults, in parallel with the continuing rise in obesity. The cost of treating diabetes complications imposes a tremendous burden on healthcare resources, and there has been limited success in achieving the treatment targets which are clearly associated with reduced risks of complications and mortality. This paper reviews the relationship of obesity to the risk and health complications of diabetes, and the impact of weight loss in reducing the risk of developing diabetes and in reducing the severity of metabolic and cardiovascular consequences in individuals who have already developed diabetes.

The Ants Go Marching Millions by Millions: Invasive Ant Research

USDA-ARS?s Scientific Manuscript database

Invasive ants are a worldwide problem that is expanding both geographically and in intensity. Population explosions of invasive ants can overrun landscapes and inundate structures. Pest management professionals are often the first responders to complaints about invading ants. This session will fo...

The ants go marching millions by millions: invasive ant research

USDA-ARS?s Scientific Manuscript database

Invasive ants are a worldwide problem that is expanding both geographically and in intensity. Population explosions of invasive ants can overrun landscapes and inundate structures. Pest management professionals are often the first responders to complaints about invading ants. This session will fo...

Global status report on road safety : time for action

DOT National Transportation Integrated Search

2009-01-01

The Global status report on road safety reaffirms our understanding of road traffic injuries as a global health and development problem. More than 1.2 million people die on the world's road every year, and as many as 50 million others are injured. Ov...

Libya: a dynamic Arab oil power

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hobbs, M.

1965-06-01

Libya has become the most dynamic oil-producing nation in the world. Less than 4 yr ago, Libya exported only peanuts, olive oil, and hides. Today, in crude-oil production Libya ranks eighth in the world, with daily production of 1.2 million bbl. Twenty-five oil companies hold concessions and have spent $1.3 billion developing reserves. Petroleum has brought new wealth to the country- an estimated $272 million in 1965. Some 2.75 million ft of hole was drilled in 1964, resulting in 97 oil fields and 4 major basins. Lost circulation has been a problem Transportation and communication are difficult in the vastmore » Libyan desert. Water-contaminated crude and high salt content have plagued production. These problems are being solved. With 45 drillings rigs active, crude production is expected to reach 2 million bpd by 1966. Most of the rigs used are trailer-mounted, unitized 8,000-12,000 ft capacity, that have been specially adapted to work in the Sahara. The drilling-completion programs are briefly described.« less

Surgical Care Required for Populations Affected by Climate-related Natural Disasters: A Global Estimation.

PubMed

Lee, Eugenia E; Stewart, Barclay; Zha, Yuanting A; Groen, Thomas A; Burkle, Frederick M; Kushner, Adam L

2016-08-10

Climate extremes will increase the frequency and severity of natural disasters worldwide.  Climate-related natural disasters were anticipated to affect 375 million people in 2015, more than 50% greater than the yearly average in the previous decade. To inform surgical assistance preparedness, we estimated the number of surgical procedures needed.   The numbers of people affected by climate-related disasters from 2004 to 2014 were obtained from the Centre for Research of the Epidemiology of Disasters database. Using 5,000 procedures per 100,000 persons as the minimum, baseline estimates were calculated. A linear regression of the number of surgical procedures performed annually and the estimated number of surgical procedures required for climate-related natural disasters was performed. Approximately 140 million people were affected by climate-related natural disasters annually requiring 7.0 million surgical procedures. The greatest need for surgical care was in the People's Republic of China, India, and the Philippines. Linear regression demonstrated a poor relationship between national surgical capacity and estimated need for surgical care resulting from natural disaster, but countries with the least surgical capacity will have the greatest need for surgical care for persons affected by climate-related natural disasters. As climate extremes increase the frequency and severity of natural disasters, millions will need surgical care beyond baseline needs. Countries with insufficient surgical capacity will have the most need for surgical care for persons affected by climate-related natural disasters. Estimates of surgical are particularly important for countries least equipped to meet surgical care demands given critical human and physical resource deficiencies.

Community-Based Global Health Program for Maltreated Children and Adolescents in Brazil: The Equilibrium Program.

PubMed

Marques, Andrea Horvath; Oliveira, Paula Approbato; Scomparini, Luciana Burim; Silva, Uiara Maria Rêgo E; Silva, Angelica Cristine; Doretto, Victoria; de Medeiros Filho, Mauro Victor; Scivoletto, Sandra

2015-01-01

The maltreatment of children and adolescents is a global public health problem that affects high- and low-middle income countries ("LMICs"). In the United States, around 1.2 million children suffer from abuse, while in LMICs, such as Brazil, these rates are much higher (an estimated 28 million children). Exposition to early environmental stress has been associated with suboptimal physical and brain development, persistent cognitive impairment, and behavioral problems. Studies have reported that children exposed to maltreatment are at high risk of behavioral problems, learning disabilities, communication and psychiatric disorders, and general clinical conditions, such as obesity and systemic inflammation later in life. The aim of this paper is to describe The Equilibrium Program ("TEP"), a community-based global health program implemented in São Paulo, Brazil to serve traumatized and neglected children and adolescents. We will describe and discuss TEP's implementation, highlighting its innovation aspects, research projects developed within the program as well as its population profile. Finally, we will discuss TEP's social impact, challenges, and limitations. The program's goal is to promote the social and family reintegration of maltreated children and adolescents through an interdisciplinary intervention program that provides multi-dimensional bio-psycho-social treatment integrated with the diverse services needed to meet the unique demands of this population. The program's cost effectiveness is being evaluated to support the development of more effective treatments and to expand similar programs in other areas of Brazil. Policy makers should encourage early evidence-based interventions for disadvantaged children to promote healthier psychosocial environments and provide them opportunities to become healthy and productive adults. This approach has already shown itself to be a cost-effective strategy to prevent disease and promote health.

Community-Based Global Health Program for Maltreated Children and Adolescents in Brazil: The Equilibrium Program

PubMed Central

Marques, Andrea Horvath; Oliveira, Paula Approbato; Scomparini, Luciana Burim; Silva, Uiara Maria Rêgo e; Silva, Angelica Cristine; Doretto, Victoria; de Medeiros Filho, Mauro Victor; Scivoletto, Sandra

2015-01-01

The maltreatment of children and adolescents is a global public health problem that affects high- and low-middle income countries (“LMICs”). In the United States, around 1.2 million children suffer from abuse, while in LMICs, such as Brazil, these rates are much higher (an estimated 28 million children). Exposition to early environmental stress has been associated with suboptimal physical and brain development, persistent cognitive impairment, and behavioral problems. Studies have reported that children exposed to maltreatment are at high risk of behavioral problems, learning disabilities, communication and psychiatric disorders, and general clinical conditions, such as obesity and systemic inflammation later in life. The aim of this paper is to describe The Equilibrium Program (“TEP”), a community-based global health program implemented in São Paulo, Brazil to serve traumatized and neglected children and adolescents. We will describe and discuss TEP’s implementation, highlighting its innovation aspects, research projects developed within the program as well as its population profile. Finally, we will discuss TEP’s social impact, challenges, and limitations. The program’s goal is to promote the social and family reintegration of maltreated children and adolescents through an interdisciplinary intervention program that provides multi-dimensional bio-psycho-social treatment integrated with the diverse services needed to meet the unique demands of this population. The program’s cost effectiveness is being evaluated to support the development of more effective treatments and to expand similar programs in other areas of Brazil. Policy makers should encourage early evidence-based interventions for disadvantaged children to promote healthier psychosocial environments and provide them opportunities to become healthy and productive adults. This approach has already shown itself to be a cost-effective strategy to prevent disease and promote health. PMID:26283972

Loss of labour productivity caused by disease and health problems: what is the magnitude of its effect on Spain's economy?

PubMed

Oliva-Moreno, Juan

2012-10-01

The aim of this study is to estimate the economic impact of the non-medical costs of diseases and accidents in Spain. Its main premise sustains the idea that in addition to the number of deaths, the loss of quality of life and the pain suffered by patients and their family members as a result of diseases and accidents, there are other indicators that provide us with a better understanding of their socioeconomic impact. Our analysis provides estimates of the loss of labour productivity in Spain as a result of health problems in 2005. Our main finding suggests an estimated loss amounting to over 37,969 millions euros, of which 9,136 millions euros are due to premature deaths, 18,577 millions to permanent disability and 10,255 millions to temporary disability. The loss in labour productivity due to accidents and health problems was estimated to a figure equivalent to nearly 4.2% of the Gross Domestic Product of Spain in 2005. This study underscores the strong economic impact of non-medical costs of diseases. In addition, it stresses the need for better information systems for collecting data that is relevant to the topic at hand.

Analysis for water conflicts in a changing world

NASA Astrophysics Data System (ADS)

Lund, J. R.

2012-12-01

Like any subject which involves billions of dollars and thousands or millions of people, managing water involves serious conflicts among contending objectives and interest groups. These conflicts usually spill into the technical and scientific analysis of water resources problems and potential solutions. A favorable or unfavorable analytical outcome can be worth millions or cost millions to a stakeholder, so they have a self-interested duty to contend. This talk examines ideas for conducting analysis to improve the technical and scientific quality of public and policy discussions of controversial water problems. More than just solid technical work is needed. Investigators must organize, disseminate, and communicate their work effectively and attentively. Research must often be designed to be effective in informing policy discussions. Several sometimes conflicting strategies are available for this.

[Induced abortion: a vulnerable public health problem].

PubMed

Requena, M

1991-03-01

Induced abortion is an urgent public health problem that can be controlled if it is approached in its true complexity and with a social and humanist perspective. Induced abortion has been discussed in Chile since the last century, but not always openly. Abortion is not just an individual and collective medical problem, it is also an ethical, religious, legal, demographic, political, and psychological problem. Above all it is a problem of human rights. In the past 60 years, more than 50 countries representing 76% of the world population have liberalized their abortion legislation. Around 980 million women have some degrees of access of legal abortion. The magnitude of illegal abortion is difficult to determine because of the desire of women to hide their experiences. Estimates of the incidence of abortion in Chile made some 25 years ago are no longer valid because of the numerous social changes in the intervening years. The number of abortions in Chile in 1987 was estimated using an indirect residual method at 195,441, of which 90%, or 175,897, were induced. By this estimate, 38.8% of pregnancies in Chile end in abortion. Data on hospitalizations for complications of induced abortion show an increase from 13.9/1000 fertile aged women in 1940 to 29.1 in 1965. By 1987, with increased contraceptive usage, the rate declined to 10.5 abortions per 1000 fertile aged women. The cost of hospitalization for abortion complications in 1987, despite the decline, was still estimated at US $4.3 million, a large sum in an era of declining health resources. The problem of induced abortion can be analyzed by placing it in the context of elements affecting the desire to control fertility. 4 complexes of variables are involved: those affecting the supply of contraceptive, the demand for contraceptives, the various costs of fertility control measure, and alternatives to fertility control for satisfying various needs. The analysis is further complicated when efforts are made to understand the dynamics of the process. Awareness of fertility control is a social process that matures slowly. Contraception and abortion have different significance for fertility control, with contraception preventing pregnancy and abortion is a sense curing it. Chile has progressed far in its fertility control awareness. 2/3 of sexually active women use some form of contraception. At the same time, induced abortion is also used. It is estimated that 58% of abortions occur after a contraceptive failure. It appears that recourse to abortion would be minimized if strategies centered on supply of contraceptives were complemented by stronger efforts to develop awareness of fertility control. Delivery of contraceptives should be accompanied by complete information on their effective use. Efforts should be targeted especially at groups at high risk abortion, including adolescents and women hospitalized for complications.

SCRAP TIRE RECYCLING: CONVINCING BUSINESSES TO INTEGRATE INEXPENSIVE, CUTTING-EDGE TECHNOLOGY TO CONVERT TIRES INTO VARIOUS CONSTRUCTION MATERIALS

EPA Science Inventory

Scrap tires cause serious environmental pollution and health problems. Although worldwide figures are imprecise, it is known that one-fourth of the 283 million tires scrapped in the United States were landfilled last year. Hundreds of millions more tires ar...

Bridging the gap.

PubMed

Taniguchi, H

1998-01-01

This special report focuses on the progress made by countries who are cooperating to prevent HIV/AIDS. Cooperation occurred during the 12th World AIDS Conference held from June 28 to July 3, 1998. New development in research and treatment was reported. Of the 13,000 participants, 77% came from the North and 23% from the South. Press coverage included 1038 persons, of whom 89% were from the North. About 1000 people were in attendance due to a generous scholarship fund. In 1997, 2.3 million died of AIDS. From the beginning of the epidemic until 1997, there have been 11.7 million AIDS deaths. About 90% of the people with HIV infections live in developing countries. HIV is more prevalent in developed countries among marginalized populations. AIDS is a problem because it affects the productive age groups 15-49 years; it exacerbates poverty; it leads to higher levels of other diseases; and basic human rights of AIDS victims are often violated. HIV/AIDS is controversial because it touches on taboos. HIV-infected persons are avoided, excluded, and marginalized. Most countries have difficulty affording prevention programs or countermeasures. HIV/AIDS is an additional public health problem that is overwhelming inadequate health systems. Knowledge about HIV/AIDS is not widespread. There are proven ways to prevent AIDS. Donors are beginning to show interest in funding prevention in developing countries. Prices are being lowered by pharmaceutical companies. Hopefully, by the next conference in South Africa, a global dynamic response will be underway.

Paediatric HIV infection.

PubMed

Scarlatti, G

1996-09-28

By the year 2000 there will be six million pregnant women and five to ten million children infected with HIV-1. Intervention strategies have been planned and in some instances already started. A timely and cost-effective strategy needs to take into account that most HIV-1 infected individuals reside in developing countries. Further studies are needed on immunological and virological factors affecting HIV-1 transmission from mother to child, on differential disease progression in affected children, and on transient infection.

Emergy assessment of ecological compensation of groundwater overexploitation in Xuchang city

NASA Astrophysics Data System (ADS)

Lv, C.; Ling, M.; Cao, Q.; Guo, X.

2017-12-01

In recent 30 years, the amount of groundwater extraction in China is increasing at a rate of 2.5 billion m3 per year. And the growing amount led to form a predatory exploitation in many parts, and caused serious exploitation problems, such as land subsidence, sea water intrusion, surface runoff reduction, vegetation decline, groundwater pollution, and so on. Ecological compensation of overexploitation has become an important mean to adjust the environmental benefits distribution relationship related to the groundwater system and to alleviate the problem of groundwater overexploitation. Based on the ecological economics emergy value theory and analysis method, the emergy loss value calculation method of eco-environmental problems caused by groundwater overexploitation, such as environmental land subsidence (collapse), salt (sea) water intrusion, surface runoff reduction, vegetation deterioration and groundwater pollution, is established, and the assessment method, which takes emergy loss value as the quantity of ecological compensation of groundwater overexploitation, is put forward. This method can reflect the disaster loss degree of groundwater overexploitation more intuitively, and it helps to improve, manage and restore a series of problems caused by groundwater overexploitation, construct a scientific and reasonable groundwater ecological compensation mechanism, and provide good ecological security for the sustainable and healthy development of national economy in our country. Taking Xuchang city as an application example, the results showed that the ecological economic loss of groundwater overexploitation was 109 million in 2015, accounting for 0.3% of the total GDP. Among them, the ecological economic loss of land subsidence is the largest, which was 77 million, accounting for 70.3% of the total loss, the second one is surface runoff reducing loss, which was 27 million, accounting for 24.7% of the total loss, and underground water pollution loss is the smallest, which was 5 million, accounting for only 5% of the total loss. To sum up, the ground subsidence is the most serious problem in many ecological environment problems caused by the groundwater overexploitation in Xuchang.

Megacities air pollution problems: Mexico City Metropolitan Area critical issues on the central nervous system pediatric impact.

PubMed

Calderón-Garcidueñas, Lilian; Kulesza, Randy J; Doty, Richard L; D'Angiulli, Amedeo; Torres-Jardón, Ricardo

2015-02-01

The chronic health effects associated with sustained exposures to high concentrations of air pollutants are an important issue for millions of megacity residents and millions more living in smaller urban and rural areas. Particulate matter (PM) and ozone (O3) concentrations close or above their respective air quality standards during the last 20 years affect 24 million people living in the Mexico City Metropolitan Area (MCMA). Herein we discuss PM and O3 trends in MCMA and their possible association with the observed central nervous system (CNS) effects in clinically healthy children. We argue that prenatal and postnatal sustained exposures to a natural environmental exposure chamber contribute to detrimental neural responses. The emerging picture for MCMA children shows systemic inflammation, immunodysregulation at both systemic and brain levels, oxidative stress, neuroinflammation, small blood vessel pathology, and an intrathecal inflammatory process, along with the early neuropathological hallmarks for Alzheimer and Parkinson's diseases. Exposed brains are briskly responding to their harmful environment and setting the bases for structural and volumetric changes, cognitive, olfactory, auditory and vestibular deficits and long term neurodegenerative consequences. We need to improve our understanding of the PM pediatric short and long term CNS impact through multidisciplinary research. Public health benefit can be achieved by integrating interventions that reduce fine PM levels and pediatric exposures and establishing preventative screening programs targeting pediatric populations that are most at risk. We fully expect that the health of 24 million residents is important and blocking pediatric air pollution research and hiding critical information that ought to be available to our population, health, education and social workers is not in the best interest of our children. Copyright © 2014 Elsevier Inc. All rights reserved.

Transportation difficulties keep over half a million disabled at home

DOT National Transportation Integrated Search

2003-04-01

How people get around affects every aspect of their lives. A new Bureau of Transportation Statistics survey found that: Nationally, almost 15 million people in this country have difficulties getting the transportation they need. Of these, about 6 mil...

Case Study: OpenSSL 2012 Validation

DTIC Science & Technology

2013-08-01

there are probably millions of users who are impacted directly, and hundreds of millions who are indirectly affected. Cryptographic libraries are...UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESSES 8. PERFORMING ORGANIZATION REPORT NUMBER D-4991 H13 -001174 Institute for Defense

Obesity and asthma

PubMed Central

Baruwa, Pranab; Sarmah, Kripesh Ranjan

2013-01-01

Asthma is a chronic disorder affecting millions of people worldwide. The prevalence of asthma is around 300 million and is expected to increase another 100 million by 2025. Obesity, on the other hand, also affects a large number of individuals. Overweight in adults is defined when body mass index (BMI) is between 25 to 30 kg/m2 and obesity when the BMI >30 kg/m2. It has been a matter of interest for researchers to find a relation between these two conditions. This knowledge will provide a new insight into the management of both conditions. At present, obese asthma patients may be considered a special category and it is important to assess the impact of management of obesity on asthma symptoms. PMID:23661915

A Review of the Literature on the Multiple Dimensions of Chronic Pain in Adults with Sickle Cell Disease

PubMed Central

Taylor, Lou Ella V.; Stotts, Nancy A.; Humphreys, Janice; Treadwell, Marsha J.; Miaskowski, Christine

2010-01-01

Sickle cell disease (SCD) is a major healthcare and societal problem that affects millions of people worldwide. In Nigeria, 45,000 to 90,000 babies are born each year with SCD. In the United States, SCD is the most common genetic disorder, affecting more than 80,000 people, the majority of whom are African American. Sickle cell pain is the hallmark feature of SCD. Most of the research on pain from SCD has focused on children with acute pain associated with sickle cell crisis. Consequently, very little is known about the occurrence and characteristics of chronic pain, especially in adults with SCD. Individuals with SCD who experience chronic pain are often underserved and their pain is under-treated. This under-treatment may result in millions of dollars per year spent on emergency room visits, hospitalizations, and lost work productivity. The primary purpose of this literature review was to summarize the findings from studies that evaluated the characteristics of chronic pain in adults with SCD. Each of the studies included in this review was evaluated to determine if it provided data on the following multidimensional characteristics of chronic pain: occurrence, number of pain episodes, duration, pattern, quality, location, intensity, aggravating factors, relieving factors, and impact of pain on function. A secondary purpose was to identify gaps in knowledge and directions for future research on the multiple dimensions of chronic pain in adults with SCD. PMID:20656451

[Research on ecological population capacity based on food and water in Shandong province].

PubMed

Lin, C

1991-02-01

The population carrying capacity in Shandong Province, China, based on current food production and water supply is discusses. In 1988, the staple food production exceeded the amount needed for the minimum subsistence level of 300 kg/person. But if the food supply were to be kept at 500 kilos/person, the amount considered to be abundant, the province had a surplus population of 16.11 million. Based on a population projection of medium scenario, the projected level of food production would meet the needs for adequate food consumption. But if the level of abundant supply were to be kept, there would be 12.4 million surplus population. The shortage of water supply is a more acute problem. On the basis of the current water consumption of 514 cubic m/person, the water supply of the province could only meet the needs of 44.9 million. But the population in the province was already 80.6 million in 1988. If the water consumption was 1000 cubic m/person, which was the consumption level of the Soviet Union, the supply can only meet the needs of 23 million population. Even if the potential water resources were fully developed, the supply can only meet the needs of 65.4 million people at the end of the century. The 92.5 million projected population at the time would far exceed the water supply capacity. The severe shortage of water supply of the province would be the most serious ecological problem. Such constraint may also have considerable impact on the sustained socioeconomic development of the province.

Airborne asphyxia: an international problem

DOE Office of Scientific and Technical Information (OSTI.GOV)

Friedlander, G.D.

1965-10-01

An overview is presented of air pollution which has become a real problem that affects virtually every major industrial city in the United States and Europe. Air pollution presents one of the most serious threats to the coal industry which produces about 55% of the electric power in the USA. There are meteorological and climatological factors that influence the action of air borne pollutants. The effects of SO/sub 2/ and N/sub 2/O on human health are discussed. Methods of reducing SO/sub 2/ emissions are presented. The results of studies by TVA in SO/sub 2/ monitoring and control have been appliedmore » in planning subsequent plants. There are an estimated 88 million motor vehicles on the nation's highways that contribute to air pollution. Control devices for cars can effectively reduce the amount of air contaminants released from motor vehicle exhausts. From numerous surveys, it is obvious that the sources of air pollution are numerous and complex. Total and effective remedial action must be undertaken to correct the situation.« less

Tobacco and health in India.

PubMed

Rao, V; Chaturvedi, P

2010-07-01

Tobacco is a well-acknowledged social and health evil. The history of tobacco use traces back to the dawn of human civilization and has been deeply entrenched into the human society since time immemorial. The social, economic, and health impact of tobacco has been a subject of intense debate over the recent decades. For India, this problem has been a unique one, with the consumption patterns either largely influenced by the socioeconomic backgrounds or dictated by the cultural diversity. With more than 200 million tobacco consumers in the country at present, it becomes imperative to address this health hazard and stir up strong measures toward damage control. This article addresses the tobacco problem, its evolution, and the factors that have affected the growth of Indian tobacco industry. It also highlights the current legislative measures against tobacco, fiscal gains to the government, and the serious health and economic impact to the consumer, compounded by the increasing cost of private health care in the present era of consumerism.

Initiating malaria control programs in the third world: directives for short- and long-term solutions.

PubMed

Basu, Sanjay

2002-01-01

Although malaria is a growing problem affecting several hundred million people each year, many malarial countries lack successful disease control programs. Worldwide malaria incidence rates are dramatically increasing, generating fear among many people who are witnessing malaria control initiatives fail. In this paper, we explore two options for malaria control in poor countries: (1) the production and distribution of a malaria vaccine and (2) the control of mosquitoes that harbor the malaria parasite. We first demonstrate that the development of a malaria vaccine is indeed likely, although it will take several years to produce because of both biological obstacles and insufficient research support. The distribution of such a vaccine, as suggested by some economists, will require that wealthy states promise a market to pharmaceutical companies who have traditionally failed to investigate diseases affecting the poorest of nations. But prior to the development of a malaria vaccine, we recommend the implementation of vector control pro- grams, such as those using Bti toxin, in regions with low vector capacity. Our analysis indicates that both endogenous programs in malarial regions and molecular approaches to parasite control will provide pragmatic solutions to the malaria problem. But the successful control of malaria will require sustained support from wealthy nations, without whom vaccine development and vector control programs will likely fail.

Child Labour Remains "Massive Problem."

ERIC Educational Resources Information Center

World of Work, 2002

2002-01-01

Despite significant progress in efforts to abolish child labor, an alarming number of children are engaged in its worst forms. Although 106 million are engaged in acceptable labor (light work for those above the minimum age for employment), 246 million are involved in child labor that should be abolished (under minimum age, hazardous work). (JOW)

Clustering Millions of Faces by Identity.

PubMed

Otto, Charles; Wang, Dayong; Jain, Anil K

2018-02-01

Given a large collection of unlabeled face images, we address the problem of clustering faces into an unknown number of identities. This problem is of interest in social media, law enforcement, and other applications, where the number of faces can be of the order of hundreds of million, while the number of identities (clusters) can range from a few thousand to millions. To address the challenges of run-time complexity and cluster quality, we present an approximate Rank-Order clustering algorithm that performs better than popular clustering algorithms (k-Means and Spectral). Our experiments include clustering up to 123 million face images into over 10 million clusters. Clustering results are analyzed in terms of external (known face labels) and internal (unknown face labels) quality measures, and run-time. Our algorithm achieves an F-measure of 0.87 on the LFW benchmark (13 K faces of 5,749 individuals), which drops to 0.27 on the largest dataset considered (13 K faces in LFW + 123M distractor images). Additionally, we show that frames in the YouTube benchmark can be clustered with an F-measure of 0.71. An internal per-cluster quality measure is developed to rank individual clusters for manual exploration of high quality clusters that are compact and isolated.

Workplace violence: impact, causes, and prevention.

PubMed

Dillon, Bobbie L

2012-01-01

Using a variety of sources, the author explores the complex reasons for aggression and violence in workplace settings, as well as suggesting means of prevention and intervention. Literature Review. Studies indicate workplace violence affects more than half of U.S. organizations, yet nearly 70 percent have no programs or policies to deal with this problem. Research indicates that aggressive behavior of a psychological nature often precedes physical violence in the workforce, yet employers regularly ignore warning signs even when reported by employees. Costs to U.S. employers are estimated in the millions due to employee absences, medical costs, theft, and costs related to litigation. Organizations with cultures which support fair working conditions and zero-tolerance for workplace aggression have been shown to help mitigate workplace violence.

Kidney disease models: tools to identify mechanisms and potential therapeutic targets

PubMed Central

Bao, Yin-Wu; Yuan, Yuan; Chen, Jiang-Hua; Lin, Wei-Qiang

2018-01-01

Acute kidney injury (AKI) and chronic kidney disease (CKD) are worldwide public health problems affecting millions of people and have rapidly increased in prevalence in recent years. Due to the multiple causes of renal failure, many animal models have been developed to advance our understanding of human nephropathy. Among these experimental models, rodents have been extensively used to enable mechanistic understanding of kidney disease induction and progression, as well as to identify potential targets for therapy. In this review, we discuss AKI models induced by surgical operation and drugs or toxins, as well as a variety of CKD models (mainly genetically modified mouse models). Results from recent and ongoing clinical trials and conceptual advances derived from animal models are also explored. PMID:29515089

Retinal prosthesis system: a revolutionary advancement for the severely visually impaired

NASA Astrophysics Data System (ADS)

2018-04-01

Despite all the advancements in modern ophthalmology, disease can affect vision, resulting in blindness. Worldwide, there are 200 000 people who have retinitis pigmentosa, 2 million with age-related macular degeneration (AMD) and 6 million have other forms of sight loss.

[Tuberculosis pulmonum--"threaten us of epidemic"?].

PubMed

Chyczewska, Elzbieta

2008-01-01

Tuberculosis (TB) remains a deadly infectious disease affecting millions of people worldwide with 95% of cases and 98% of deaths occuring in developing countries (9 milion new cases, 1 million deaths annually) vs.WHO. Tuberculosis is on the increase in developed countries, because of AIDS, the use of immunosuppresive drugs which depress the host defence mechanism, decreased socioeconomic conditions, as well as increased immigration of persons from areas of high endemicity. The major reason for this increase was because of rapid rise in cases from sub-Saharan Africa (due to AIDS) nad Russia. Incidense of tuberculosis in Poland 2007--the number of notified cases was 8014. Pulmonary cases represented 92.7% of total all TB cases and 628 cases of extrapulmonary TB. Chidren TB cases represented 0.9% (74 cases) of all cases notified in Poland. The incidence of tuberculosis increases with age from 1.1 in children do 41.2 among 65 and older. The incidence of men (31.5) was two times higher than in women--14.5 per 100 000 respectivly. There were 716 deaths due to pulmonary TB and 23 from extrapulmonary TB. Multidrug resistance (MDR) of Mycobacterium tuberculosis is a major therapeutic problem, in the world, with a high mortality and occurs mainly in HIV-infected patients. The WHO estimates that around 50 million people are infected with MDR-TB! WHO suggest that a greater investment in the establishment treatment strategy of DOTS (Directly Observed Treatment Short-course) into all posible regions.

Present epidemiology of tuberculosis. Prevention and control programs.

PubMed

Orcau, Àngels; Caylà, Joan A; Martínez, José A

2011-03-01

Tuberculosis (TB) has affected humanity since the beginning of the recorded time and is associated with poverty, malnutrition, overcrowding, and immunosuppression. Since Koch discovered the infectious nature of the disease in 1882, knowledge about its history and physiopathology has advanced, but it continues to be a global public health problem. More than 9 million new cases occurred in 2008 worldwide (with an incidence of 139/100,000 inhabitants), of whom more than one million died. Over half million of the cases presented with multidrug resistant-TB. Africa represents the continent with the highest incidence and the most HIV co-infection. The situation in Eastern Europe is also worrisome because of the high incidence and frequency drug resistance. In developed countries, TB has been localized in more vulnerable populations, such as immigrants and persons with social contention. There is an increase of extra-pulmonary presentation in this context, related to non-European ethnicity, HIV infection, and younger age. In Spain, the increasing immigrant population has presented a need to improve coordination between territories and strengthen surveillance The global control plan is based on the DOTS strategy, although the objectives and activities were redefined in 2006 to incorporate the measurement of global development, and community and healthcare strengthening. Adequate control measures in a more local context and continual activity evaluation are necessary to decrease the burden of suffering and economic loss that causes this ancient disease. Copyright © 2011 Elsevier España S.L. All rights reserved.

Corneal blindness: a global perspective.

PubMed Central

Whitcher, J. P.; Srinivasan, M.; Upadhyay, M. P.

2001-01-01

Diseases affecting the cornea are a major cause of blindness worldwide, second only to cataract in overall importance. The epidemiology of corneal blindness is complicated and encompasses a wide variety of infectious and inflammatory eye diseses that cause corneal scarring, which ultimately leads to functional blindness. In addition, the prevalence of corneal disease varies from country to country and even from one population to another. While cataract is responsible for nearly 20 million of the 45 million blind people in the world, the next major cause is trachoma which blinds 4.9 million individuals, mainly as a result of corneal scarring and vascularization. Ocular trauma and corneal ulceration are significant causes of corneal blindness that are often underreported but may be responsible for 1.5-2.0 million new cases of monocular blindness every year. Causes of childhood blindness (about 1.5 million worldwide with 5 million visually disabled) include xerophthalmia (350,000 cases annually), ophthalmia neonatorum, and less frequently seen ocular diseases such as herpes simplex virus infections and vernal keratoconjunctivitis. Even though the control of onchocerciasis and leprosy are public health success stories, these diseases are still significant causes of blindness--affecting a quarter of a million individuals each. Traditional eye medicines have also been implicated as a major risk factor in the current epidemic of corneal ulceration in developing countries. Because of the difficulty of treating corneal blindness once it has occurred, public health prevention programmes are the most cost-effective means of decreasing the global burden of corneal blindness. PMID:11285665

America's neglected veterans: 1.7 million who served have no health coverage.

PubMed

Woolhandler, Steffie; Himmelstein, David U; Distajo, Ronald; Lasser, Karen E; McCormick, Danny; Bor, David H; Wolfe, Sidney M

2005-01-01

Many U.S. military veterans lack health insurance and are ineligible for care in Veterans Administration health care facilities. Using two recently released national government surveys--the 2004 Current Population Survey and the 2002 National Health Interview Survey--the authors examined how many veterans are uninsured (lacking health insurance coverage and not receiving care from the VA) and whether uninsured veterans have problems in access to care. In 2003, 1.69 million military veterans neither had health insurance nor received ongoing care at Veterans Health Administration (VHA) hospitals or clinics; the number of uninsured veterans increased by 235,159 since 2000. The proportion of nonelderly veterans who were uninsured rose from 9.9 percent in 2000 to 11.9 percent in 2003. An additional 3.90 million members of veterans' households were also uninsured and ineligible for VHA care. Medicare covered virtually all Korean War and World War II veterans, but 681,808 Vietnam-era veterans were uninsured (8.7 percent of the 7.85 million Vietnam-era vets). Among the 8.27 million veterans who served during "other eras" (including the Persian Gulf War), 12.1 percent (999,548) lacked health coverage. A disturbingly high number of veterans reported problems in obtaining needed medical care. By almost any measure, uninsured veterans had as much trouble getting medical care as other uninsured persons. Thus millions of U.S. veterans and their family members are uninsured and face grave difficulties in gaining access to even the most basic medical care.

A Catalyst for Change: Drought and Food Security in the Near East Region (Invited)

NASA Astrophysics Data System (ADS)

Knutson, C. L.

2010-12-01

In the Near East, drought at the turn of the 21st century was reported to be the worst in 50 years, affecting millions of people across the region. The drought caused a wide range of effects, including widespread crop failures and livestock losses, increased drinking water shortages and disease stress, additional debt, and forced mass migrations to urban areas and other countries, all of which affected food security. As devastating as the drought was for people and the environment, the event created a “policy window” - a time during which the public’s and policy makers’ attention was directed toward a particular issue, creating an advantageous political environment for addressing the problem. In this case, the drought revealed the need for enhanced mitigation and drought relief coordination. It has served as the impetus for several countries and international organizations to work together to foster new policies and training activities to reduce drought risk and enhance food security in the region.

Understanding nocturnal enuresis and its treatments.

PubMed

Potter, D C; Wogoman, H A; Nietch, P

1999-09-01

Nocturnal enuresis is a condition that touches the lives of many children around the world. Affected children and their parents may experience feelings of guilt, frustration, and anxiety because of their lack of control over the situation. Nurses can play an important role in providing education to families in regards to the causes and treatment of enuresis. It is important for nurses to understand the problem of bedwetting thoroughly so they can assist the family in making an informed decision about the various options currently available. Nocturnal enuresis (bedwetting) is a common disorder that frequently results in frustration and stress on not only the children that experience it, but their parents as well. Scharf, Pravda, Jennings, Kauffman, and Ringel (1987) note that an estimated five to seven million children in America experience enuresis. Enuresis has family and psychosocial aspects, along with financial concerns. Therefore, it is important for nurses to be aware of the causes of enuresis, how it affects the family, and the current treatments that are available.

Impact of physical activity on ovarian reserve markers in normal, overweight and obese reproductive age women.

PubMed

Surekha, T; Himabindu, Y; Sriharibabu, M; Pandey, Anil Kumar

2014-01-01

Physical inactivity is a leading risk factor for overweight and obesity in the society. Prevalence of overweight and obesity in the reproductive age group women not only affects maternal health but also the health of the off spring. Infertility is a common problem in India affecting 13-19 million people at any given time. Even though it is not life threatening, infertility causes intense mental agony and trauma that can only be best described by infertile couples themselves. Infertility is more common in overweight and obese individuals compared to normal weight individuals. Decreasing ovarian reserve is an important factor for infertility in women. This study examined the impact of physical activity on ovarian reserve markers in normal, overweight and obese reproductive age women. The observations made in this study reveal that physical activity improves ovarian reserve markers in all reproductive age women but this improvement is more distinct and statistically significant in overweight and obese women compared to normal weight women.

Sustainable development: a regional perspective.

PubMed

Icamina, P

1988-12-01

This article discusses sustainable development in Asia and current environmental problems in this region. Droughts and rainy seasons pose a major concern indicating environmental limitations: India's 1987 drought halted world grain production and China suffered US $435 million in flooding damage. Deforestation and land degradation are consequences of a rising population's demand for agriculture, fuelwood, irrigation, and hydroelectric projects; 1815 million hectares of forest are cleared/year and 40% of the land could possible be subjected to soil erosion. Although population growth is declining in some Asian countries, the continent inhabits the greatest proportion of world population; 300 million are underfed. Food production remains a problem for this region because of bad weather, highly populated areas, less cropland, soil erosion, and limited water supply. Efforts currently employed to conserve natural resources include community reforestation, providing available drinking water, substituting firewood for fuelwood, and delivering primary health care.

Noninvasive assessment of liver fibrosis in patients with chronic hepatitis B.

PubMed

Enomoto, Masaru; Morikawa, Hiroyasu; Tamori, Akihiro; Kawada, Norifumi

2014-09-14

Infection with hepatitis B virus is an important health problem worldwide: it affects more than 350 million people and is a leading cause of liver-related morbidity, accounting for 1 million deaths annually. Hepatic fibrosis is a consequence of the accumulation of extracellular matrix components in the liver. An accurate diagnosis of liver fibrosis is essential for the management of chronic liver disease. Liver biopsy has been considered the gold standard for diagnosing disease, grading necroinflammatory activity, and staging fibrosis. However, liver biopsy is unsuitable for repeated evaluations because it is invasive and can cause major complications, including death. Several noninvasive evaluations have been introduced for the assessment of liver fibrosis: serum biomarkers, combined indices or scores, and imaging techniques including transient elastography, acoustic radiation force impulse, real-time tissue elastography, and magnetic resonance elastography. Here, we review the recent progress of noninvasive assessment of liver fibrosis in patients with chronic hepatitis B. Most noninvasive evaluations for liver fibrosis have been validated first in patients with chronic hepatitis C, and later in those with chronic hepatitis B. The establishment of a noninvasive assessment of liver fibrosis is urgently needed to aid in the management of this leading cause of chronic liver disease.

Ongoing Coverage for Ongoing Care: Access, Utilization, and Out-of-Pocket Spending Among Uninsured Working-Aged Adults with Chronic Health Care Needs

PubMed Central

Rasch, Elizabeth K.; Chan, Leighton

2011-01-01

Objectives. We sought to determine how part-year and full-year gaps in health insurance coverage affected working-aged persons with chronic health care needs. Methods. We conducted multivariate analyses of the 2002–2004 Medical Expenditure Panel Survey to compare access, utilization, and out-of-pocket spending burden among key groups of persons with chronic conditions and disabilities. The results are generalizable to the US community-dwelling population aged 18 to 64 years. Results. Among 92 million adults with chronic conditions, 21% experienced at least 1 month uninsured during the average year (2002–2004). Among the 25 million persons reporting both chronic conditions and disabilities, 23% were uninsured during the average year. These gaps in coverage were associated with significantly higher levels of access problems, lower rates of ambulatory visits and prescription drug use, and higher levels of out-of-pocket spending. Conclusions. Implementation of health care reform must focus not only on the prevention of chronic conditions and the expansion of insurance coverage but also on the long-term stability of the coverage to be offered. PMID:21164090

Systemic violence against Syrian refugee women and the myth of effective intrapersonal interventions.

PubMed

Yasmine, Rola; Moughalian, Catherine

2016-05-01

Since the uprising in Syria in March 2011, over 4.3 million Syrians have fled to neighboring countries. Over a million have sought refuge in Lebanon, constituting almost a quarter of the Lebanese population and becoming the largest refugee population per capita in the world. With inequitable health coverage being a longstanding problem in Lebanon, Syrian refugee women's health, and specifically their sexual and reproductive health, is disproportionately affected. An increase in gender-based violence and early marriage, a lack of access to emergency obstetric care, limited access to contraception, forced cesarean sections, and high cost of healthcare services, all contribute to poor sexual and reproductive health. In this commentary, we conceptualize violence against Syrian refugee women using the ecological model, exploring the intersections of discrimination based on ethnicity, gender, and socioeconomic status, while critiquing interventions that focus solely on the intrapersonal level and ignore the role of microsystemic, exosystemic, and macrosystemic factors of negative influence. These social determinants of health supersede the individual realm of health behavior, and hinder women in taking decisions about their sexual and reproductive health. Copyright © 2016 Elsevier Inc. All rights reserved.

Burden of osteoporosis and fractures.

PubMed

Keen, Richard W

2003-09-01

Osteoporosis currently affects up to one in three women and one in 12 men. In 1990, there were 1.6 million hip fractures per annum worldwide and this number is estimated to reach 6 million by 2050. This increase in the number of fractures is due to an increase in the number of elderly people in the population, improved survival, and an increase in the age-specific fracture rates of unknown etiology. The rising number of osteoporotic fractures and their associated morbidity will place a heavy burden on future health care resources. In the United States, the cost for the management of osteoporosis has been estimated at $17 billion. The majority of this cost is spent on the acute surgical and medical management following hip fracture, and the subsequent rehabilitation. Currently, only minimal costs are utilized for treatment and prevention of osteoporosis. Hopefully, however, an accurate assessment of the burden of osteoporosis on the individual and the health care system will enable the targeting of resources to tackle this growing problem. With an increasing number of effective pharmaceutical interventions, it is critical that these agents are targeted to those at greatest risk for future fracture. This will ultimately reduce the burden of osteoporosis in future years.

AUTOMATION AND UNEMPLOYMENT.

ERIC Educational Resources Information Center

SCHMIDT, EMERSON P.; STEWART, CHARLES T.

HIGH UNEMPLOYMENT RESULTS IN ECONOMIC LOSSES TO THE ECONOMY AND IMPOSES SUFFERING ON MILLIONS OF INDIVIDUALS AND FAMILIES. OF THE MANY TYPES, LONG-TERM STRUCTURAL UNEMPLOYMENT AFFECTS MORE THAN ONE MILLION WORKERS AND IS MOST INTRACTABLE TO TREATMENT AND DISTURBING IN TERMS OF HUMAN HARDSHIP. MOST OF THE WORKERS CLASSIFIED AS STRUCTURALLY…

The current cost of angina pectoris to the National Health Service in the UK

PubMed Central

Stewart, S; Murphy, N; Walker, A; McGuire, A; McMurray, J J V

2003-01-01

Objective: To calculate the cost of angina pectoris to the UK National Health Service (NHS) in the year 2000. Methods: Calculation of the cost of hospital admissions, revascularisation procedures, hospital outpatient consultations, general practice (GP) consultations, and prescribed drug treatment. Results: 634 000 individuals (1.1% of the UK population) consulted GPs 2.35 million times, costing £60.5 million. They required 16.0 million prescriptions (cost £80.7 million) and 254 000 hospital outpatient referrals (cost £30.4 million). There were 149 000 hospital admissions, 117 000 coronary angiograms, 21 400 coronary artery bypass operations, 17 700 percutaneous coronary interventions, and 516 000 outpatient visits, at a cost of £208.4 million, £69.9 million, £106.2 million, £60.7 million, and £52.2 million, respectively. The direct cost of angina was therefore £669 million (1.3% of total NHS expenditure), with hospital bed occupancy and procedures accounting for 32% and 35% of this total, respectively. Conclusions: Angina is a common and costly public health problem. It consumed over 1% of all NHS expenditure in the year 2000, mainly because of hospital bed occupancy and revascularisation procedures. This is likely to be a conservative estimate of its true cost. PMID:12860855

Affects of Microgravity on the Polymerization and Material Properties of Biomedical Grade Polymers

NASA Astrophysics Data System (ADS)

Crane, Deborah J.

2002-01-01

the material of choice in the production of acetabular cups for hip and tibial cradles for knee orthopeadic implant components for over 30 years. Although UHMWPE is used for more than 1.5 million implants a year in the United States alone and more than 3 million implant surgeries a year worldwide, problems with debris particle formation, pitting and fracture continue to induce premature failure of implant components. chains produced during polymerization are capable of packing into crystalline structures called lamellae, which are embedded within randomly oriented amorphous regions. Crosslinks, or tie molecules bridge the crystalline structures, which contribute to the materials' toughness and strength as a biomedical material. Research has been conducted providing evidence that a crosslinked gradient at the articulating surface of the polymer component provides resistance to surface degradation and subsequent debris formation. Recently, the introduction of highly crosslinked UHMWPE had proven to reduce some of the problems associated with the applications of this polymer as a biomedical material and was seen as the answer to solving the continuing problems associated with UHMWPE implant components. Yet current research into the fatigue characteristics of highly crosslinked UHMWPE has shown that subsurface crack propagation and subsequent delamination continues to produce problematic debris generation. Studies have shown that various sterilization and accelerated aging (to emulate natural oxidation rates) protocols adversely effects the material properties. Additional research has shown that alignment of the lamellae, caused by processing technique, fabrication or surface articulation may be the precursor to debris particle formation. Processing techniques performed under high pressure has proven to effect the width of the crystalline lamellae and therefore, the material's response to wear and fracture. UHMWP due to a microgravity environment, which could be extended to include other polymers. Polymerization as well as polymer processing in a microgravity environment may affect the length and orientation of the molecular chains, the degree of crosslinking, and distribution of amorphous to crystalline portions of the material, thus changing the ultimate properties of the polymer. Small polymer samples would be produced from the resin for testing and analysis. This research would include the effect of micro-g processing by compression molded vs. ram extruded samples for analysis. Morphological alterations in the material could be monitored using Transmission Electron Microscopy and associated properties such as toughness, density and crystallinity could be determined and compared to terra produced materials using conventional mechanical testing, density gradient columns and calorimetry techniques. If alterations are evident, fatigue testing can be performed on small specimens in order to determine the material's resistance to crack initiation and propagation. number of orthopaedic implant recipients and could be extended for use in robotics and other beneficial applications. Although polymers exhibit the greatest biocompatibility, problems with debris particle generation continue to reduce the effectiveness of UHMWPE as a biomedical material. Further polymer research in a microgravity environment may prove to produce the desired alterations in the materials' morphology and associated properties, therefore providing millions of people with superior orthopaedic implant components and lessen the occurrences of repeat surgery.

Solving the Ancient Maritime Problem: Piracy Operations in the Gulf of Aden

DTIC Science & Technology

2010-04-22

of2009, pirates captured the Greek-flagged tanker Maran Centaurus while it was carrying 275,000 metric tons of crude oi1.28 That is equivalent to about 2...million barrels of oil worth roughly $150 million, stated Ben Cahill, head of the Petroleum Risk Manager service at PFC Energy. Maran Centaurus was

Root disease and other unforeseen variables that confound restoration efforts

Treesearch

William J. Otrosina; Shi-Jean S. Sung; Stanley J. Zarnoch; Brian T. Sullivan; Charles H. Walkinshaw

2002-01-01

Unanticipated disease problems thwarting restoration efforts can emerge in forest ecosystems. An example is the longleaf pine (Pinus palustris Mill.) ecosystem. This species once occupied nearly 30 million ha but now its range is reduced to approximately 1.5 million ha. Restoring longleaf pine to many sites in its former range is an important goal...

Work disability resulting from chronic health conditions.

PubMed

Lerner, Debra; Allaire, Saralynn H; Reisine, Susan T

2005-03-01

To describe current programs and policies for addressing work disability among adults with chronic health conditions, and to identify opportunities for new research aimed at reducing the problem. The authors conducted secondary data analysis and a literature review. Millions of Americans with a chronic health condition have a work disability or are at risk of developing one. This public health problem is costing hundreds of billions of dollars a year nationally in lost productivity and diminishing the quality of life of millions of Americans. The medical care system, employers, and government--three traditional sources of help for adults with chronic health problems--are not sufficiently oriented toward the primary or secondary prevention of work disability. New research is urgently needed to reduce the burden of work disability on individuals and society.

The Effects of American Sign Language on General Self-Efficacy and Anxiety among Mothers in a Residential Rehabilitation Facility for Drug Addiction and Substance Abuse

ERIC Educational Resources Information Center

Kissel, Bonnie J.

2010-01-01

Globally, approximately 208 million people aged 15 and older used illicit drugs at least once in the last 12 months; 2 billion consumed alcohol and tobacco consumption affected 25% (World Drug Report, 2008). In the United States, 20.1 million (8.0%) people aged 12 and older were illicit drug users, 129 million (51.6%) abused alcohol and 70.9…

Psychological impact of female genital mutilation among adolescent Egyptian girls: a cross-sectional study.

PubMed

Ahmed, Magdy R; Shaaban, Mohamed M; Meky, Heba K; Amin Arafa, Mohamed E; Mohamed, Tamer Y; Gharib, Waleed F; Ahmed, Abeer B

2017-08-01

Worldwide, at least 200 million women and girls have undergone female genital mutilation (FGM). The medical and sexual consequences have been documented, but the psychological impact has not been studied to the same extent. The aim of this study was to explore the relationship between FGM and psychiatric problems among adolescent girls. A total of 204 girls, aged 14-19 years, were included in a cross-sectional study conducted at Suez Canal University Hospitals. All participants completed an Arabic-validated, structured questionnaire covering nine symptom scales. Sociodemographic data were also collected. Main outcome measures were the prevalence of psychiatric problems among adolescent girls who had undergone FGM. Overall, 66.2% of girls had undergone FGM. The percentage in rural areas was 91.8%, compared with 43.0% in urban areas. There were no significant differences between the FGM and non-FGM groups as regards religion, educational and socioeconomic levels. FGM girls had a significantly higher level of psychological problems with regard to somatisation, depression, anxiety, phobic anxiety and hostility compared with non-FGM girls (p < .0001). FGM is a traumatic experience that may leave a lasting psychological mark and a negative impact on the psychological status of affected girls.

Stresses and storms: the case of Bangladesh.

PubMed

Ahmad, N

1993-01-01

The problems of women and environmental degradation have recently come to be addressed by women's groups, nongovernmental organizations (NGOs), and government policies in Bangladesh. NGOs have been the most active, with 600 registered organizations: 40% international, 38% national, and 22% local. NGOs have promoted the recent inclusion of environmental concerns into development plans. About 100 NGOs are engaged in forestry projects. The National Association for Resource Improvement, for example, involves women in tree planting along roadsides and income-generating activities. About 75% of upazilas (administrative units) have environmental and women's projects, but under 20% of all villages are affected and 1% of landless people are reached. Women's groups have created awareness of women's problems and advocated for socioeconomic changes. Women, despite cultural and social restrictions on their social behavior, have changed environmental and economic conditions. Women's leadership and organizing abilities have contributed to public awareness of environmental degradation. Because Bangladesh is a delta, a rise in sea level from greenhouse effects would have serious consequences for the land and population. Global warming has contributed to river flooding and climate changes that have increased rainfall and tropical storms. Deforestation upriver adds to the water runoff problems. About 20% of the cultivable land area is affected by natural disasters. Population density is 760 persons per sq km. About 50% of forested areas have been destroyed within the past 20 years. 4% of gross domestic product comes from forest activity. The lack of wood fuel limits the ability of people to boil water and contributes to the increased incidence of diarrhea, other intestinal problems, and less nutritious food. Drought is another problem. Urban migration has overwhelmed the ability of urban centers to provide basic services. Coastal areas have been settled by 20% of total population, but coastal storms regularly impact on people's lives and livelihoods. Coastal fishing supports 1 million fishermen and 10 million in fishing-related employment. Land and water management practices and marine pollution have destroyed 40% of coastal forest areas. Excessive use of chemicals in agriculture has decreased soil fertility, produced water pollution, destroyed fishing, and jeopardized the health of agricultural workers. Women continue to have limited economic opportunities and subordinate positions in the household and economy. Women have been disadvantaged in their sex ratio, nourishment, and mortality. Although the Constitution since 1972 has guaranteed women 30 seats in the 330-member parliament and 10% of government service jobs, the gains have not been fully realized. The Five Year Plan for 1986-90 aimed to increase women's participation in economic development. More detailed plans were included in the following plan for 1991-95.

Designing an effective statewide tobacco control program--Massachusetts.

PubMed

Connolly, G; Robbins, H

1998-12-15

Smoking-related illnesses kill > 10,000 Massachusetts residents each year and cost hundreds of millions of dollars of public and private expenditures for health care. To combat this public health problem, in 1992 Massachusetts voters approved a referendum question calling for an increased excise tax on tobacco products, with the revenue supporting a Health Protection Fund. Approximately 40% of the fund is used to finance the Massachusetts Tobacco Control Program (MTCP), administered by the Massachusetts Department of Public Health. During the first 3 fiscal years (FY), the MTCP budget has averaged just over $40 million annually, declining during that period from approximately $43 million in FY 1995 to < $37 million in FY 1997.

Family Breadwinners: Their Special Training Needs.

ERIC Educational Resources Information Center

Feldman, Lloyd; Peevey, Michael R.

Family breadwinners are individuals primarily responsible for the support of family members. This report provides an economic profile of the breadwinners and outlines their special training needs. The unemployment of more than 1.7 million of the 39 million family breadwinners in the labor force in March 1962 affected the welfare of approximately…

Forest Service Resource Inventories: An Overview

Treesearch

USDA Forest Service

1992-01-01

Forest and related resource inventories are conducted by the US. Forest Service to provide the quantitative base necessary for making sound management, conservation, and stewardship decisions affecting these valuable resources. Inventory information has guided the management of 191 million acres (77.3 million ha) of publicly-owned National Forest land. Forest...

Hours Lost to Planned and Unplanned Dental Visits Among US Adults.

PubMed

Kelekar, Uma; Naavaal, Shillpa

2018-01-11

Poor oral health is associated with lost hours at work or school, which may affect a person's productivity. The objective of our study was to estimate work or school hours lost to dental visits among adults aged 18 and older by the types of visits (emergency or unplanned; routine, planned, or orthodontic; or cosmetic) and to determine the factors associated with hours lost. We used the most recent Oral Health Supplement data, from the 2008 National Health Interview Survey (NHIS), to estimate the total hours lost at work or school for dental visits among adults in the United States. The associations of the hours lost in unplanned and planned dental visits with socioeconomic characteristics, oral health status, and affordability were calculated. We used χ 2 tests and logistic regression to determine associations at P < .05. An average of 320.8 million work or school hours were lost annually for dental care in the United States, of which 92.4 million hours were for emergency (unplanned) care (0.99 h/adult), 159.8 million for routine (planned) care or orthodontic care (1.71 h/adult), and 68.6 million for cosmetic care (0.73 h/adult). Adults with poor oral health were more likely to lose one or more hours in unplanned dental visits (OR = 5.60; 95% confidence interval [CI], 3.25-9.63) than those who reported very good oral health. Not being able to afford dental care was positively associated with more work hours lost in unplanned care (odds ratio [OR] = 2.56; 95% CI, 1.76-3.73). Compared with Hispanic adults, non-Hispanic white adults (OR = 2.09; 95% CI, 1.40-3.11) and non-Hispanic Asian adults and adults of other races/ethnicities (OR =1.91; 95% CI, 1.06-3.47) were more likely to lose any hours for planned care. Consistently, those with more than a high school education were more likely to lose any hours in planned care (OR = 1.39; 95% CI, 1.06-1.83) than those with a high school education or less. Dental problems result in hours lost from work and may adversely affect a person's productivity. There is disparity in lost hours at work by race/ethnicity and dental care affordability.

HIV/AIDS issues in the workplace of nurses.

PubMed

Minnaar, A

2005-08-01

HIV/AIDS is a global problem with an estimated 40 million infected people. In less than two years, this figure will leap to 100 million according to the World Health Organisation (WHO). By 2005, 65 million people will be infected. Half of the number of people in this group will be under 25 years old, and will die before they reach the age of 35. In a South African study done by the Human Science Research Council and published in 2003, regarding the impact of HIV/AIDS on the health sector, the findings were that 15% of health workers in public and private hospitals tested positive for HIV antibodies. Together with these facts above it was found that 46.2 percent of patients served in medical and paediatric wards tested positive for HIV. These factors have major implication for staffing in the future and the role of the nurse manager in South Africa. To explore the management of HIV/AIDS in the workplace of nurses in selected health services in KwaZulu-Natal. This research was part of a greater study on the exploration of the presence of caring as part of nursing management. THE METHODOLOGY: The qualitative research approach was used with a phenomenological design, which ensured that the richness and the complexities are reflected in the study. The data was collected by means of an open-ended question to nurse managers during an interview. The first question posed was; How do you or your services care for nurses in this hospital? Secondly nurse managers were asked, To explain their role in caring for HIV/AIDS positive nurses on their staff establishment. A qualitative analysis of the interviews with nurse managers indicated that they rate HIV/AIDS issues as an important part of their management task. Four main themes were identified, namely HIV/AIDS, counselling, dying of AIDS and funerals. Rich descriptions of these themes are given in this paper. Nurse managers in the health services are managing HIV/AIDS affected nurses, but are doing so without any formal policy on HIV/AIDS in the workplace. It is recommended that nurse managers deal with HIV/AIDS issues in the workplace by raising HIV/AIDS awareness regarding HIV/AIDS issues and HIV/AIDS in the workplace. Nurse managers saw their role regarding nurses with HIV/AIDS mainly as supportive--being involved in family problems and counselling and guiding nurses that live with HIV/AIDS. The health services in KwaZulu-Natal, and especially nurses, are currently affected by HIV/AIDS in a significant way.

Health among disaster survivors and health professionals after the Haiyan Typhoon: a self-selected Internet-based web survey.

PubMed

Hugelius, Karin; Gifford, Mervyn; Örtenwall, Per; Adolfsson, Annsofie

2017-12-01

Natural disasters affected millions of people worldwide every year. Evaluation of disaster health and health response interventions is faced with several methodological challenges. This study aimed (1) to describe survivors' and health professionals' health, 30 months after a natural disaster using a web-based self-selected Internet sample survey designed and (2) to evaluate the health effects of disaster response interventions, in the present study with a focus on disaster radio. A web-based survey was used to conduct a cross-sectional study approximately 30 months after typhoon Haiyan. The GHQ-12, EQ-5D-3L, and EQ-VAS instruments were used in addition to study-specific questions. A self-selected Internet sample was recruited via Facebook. In total, 443 survivors, from what 73 were health professionals, participated in the study. The Haiyan typhoon caused both physical and mental health problems as well as social consequences for the survivors. Mental health problems were more frequently reported than physical injuries. Health professionals reported worse overall health and a higher frequency of mental health problems compared to other survivors. There were short-term and long-term physical, psychological, and social consequences for the survivors as a result of the Haiyan typhoon. Mental health problems were more frequently reported and lasted longer than physical problems. Health professionals deployed during the disaster reported worse health, especially concerning mental health problems. The survey used was found useful to describe health after disasters.

Hot mix asphalt tender zone

DOT National Transportation Integrated Search

2000-04-01

Approximately 500 million tons of hot mix asphalt (HMA) are placed in the United States each year. With this large quantity of HMA, it is expected that some construction problems will occur from time to time. One problem that has been observed for ye...

Health and productivity among U.S. workers.

PubMed

Davis, Karen; Collins, Sara R; Doty, Michelle M; Ho, Alice; Holmgren, Alyssa

2005-08-01

This analysis of Commonwealth Fund survey data estimates the economic impact of health problems on worker productivity. In 2003, an estimated 18 million adults ages 19 to 64 were not working and had a disability or chronic disease, or were not working because of health reasons. Sixty-nine million workers reported missing days due to illness, for a total of 407 million days of lost time at work. Fifty-five million workers reported a time when they were unable to concentrate at work because of their own illness or that of a family member, accounting for another 478 million days. Together, labor time lost due to health reasons represents lost economic output totaling $260 billion per year. Workers without paid time off to see a physician are more likely to report missing work or being unable to concentrate at their job.

Latent Dirichlet Allocation (LDA) for Sentiment Analysis Toward Tourism Review in Indonesia

NASA Astrophysics Data System (ADS)

Putri, IR; Kusumaningrum, R.

2017-01-01

The tourism industry is one of foreign exchange sector, which has considerable potential development in Indonesia. Compared to other Southeast Asia countries such as Malaysia with 18 million tourists and Singapore 20 million tourists, Indonesia which is the largest Southeast Asia’s country have failed to attract higher tourist numbers compared to its regional peers. Indonesia only managed to attract 8,8 million foreign tourists in 2013, with the value of foreign tourists each year which is likely to decrease. Apart from the infrastructure problems, marketing and managing also form of obstacles for tourism growth. An evaluation and self-analysis should be done by the stakeholder to respond toward this problem and capture opportunities that related to tourism satisfaction from tourists review. Recently, one of technology to answer this problem only relying on the subjective of statistical data which collected by voting or grading from user randomly. So the result is still not to be accountable. Thus, we proposed sentiment analysis with probabilistic topic model using Latent Dirichlet Allocation (LDA) method to be applied for reading general tendency from tourist review into certain topics that can be classified toward positive and negative sentiment.

Child prostitution: global health burden, research needs, and interventions.

PubMed

Willis, Brian M; Levy, Barry S

2002-04-20

Child prostitution is a significant global problem that has yet to receive appropriate medical and public health attention. Worldwide, an estimated 1 million children are forced into prostitution every year and the total number of prostituted children could be as high as 10 million. Inadequate data exist on the health problems faced by prostituted children, who are at high risk of infectious disease, pregnancy, mental illness, substance abuse, and violence. Child prostitution, like other forms of child sexual abuse, is not only a cause of death and high morbidity in millions of children, but also a gross violation of their rights and dignity. In this article we estimate morbidity and mortality among prostituted children, and propose research strategies and interventions to mitigate such health consequences. Our estimates underscore the need for health professionals to collaborate with individuals and organisations that provide direct services to prostituted children. Health professionals can help efforts to prevent child prostitution through identifying contributing factors, recording the magnitude and health effects of the problem, and assisting children who have escaped prostitution. They can also help governments, UN agencies, and non-governmental organisations (NGOs) to implement policies, laws, and programmes to prevent child prostitution and mitigate its effects on children's health.

Housing Affordability And Children's Cognitive Achievement.

PubMed

Newman, Sandra; Holupka, C Scott

2016-11-01

Housing cost burden-the fraction of income spent on housing-is the most prevalent housing problem affecting the healthy development of millions of low- and moderate-income children. By affecting disposable income, a high burden affects parents' expenditures on both necessities for and enrichment of their children, as well as investments in their children. Reducing those expenditures and investments, in turn, can affect children's development, including their cognitive skills and physical, social, and emotional health. This article summarizes the first empirical evidence of the effects of housing affordability on children's cognitive achievement and on one factor that appears to contribute to these effects: the larger expenditures on child enrichment by families in affordable housing. We found that housing cost burden has the same relationship to both children's cognitive achievement and enrichment spending on children, exhibiting an inverted U shape in both cases. The maximum benefit occurs when housing cost burden is near 30 percent of income-the long-standing rule-of-thumb definition of affordable housing. The effect of the burden is stronger on children's math ability than on their reading comprehension and is more pronounced with burdens above the 30 percent standard. For enrichment spending, the curve is "shallower" (meaning the effect of optimal affordability is less pronounced) but still significant. Project HOPE—The People-to-People Health Foundation, Inc.

Pursuing the Bottom Line: How the Middle East Will be Affected by an Aging America

DTIC Science & Technology

2007-09-01

freedom of every person to worship God in his own way, the freedom from want, and the freedom from fear…anywhere in the world. These principles...highlighted above prove to be true, the Middle East could be a tinder box for years to come. The three sources of potential instability are...million persons each year.25 Europe is expected to see its population fall from its current 731 million to 715 million by 2025 and approximately

Opportunities for making wood products from small diameter trees in Colorado

Treesearch

Dennis L. Lynch; Kurt H. Mackes

2002-01-01

Colorado's forests are at risk to forest health problems and catastrophic fire. Forest areas at high risk to catastrophic fire, commonly referred to as Red Zones, contain 2.4 million acres in the Colorado Front Range and 6.3 million acres Statewide. The increasing frequency, size, and intensity of recent forest fires have prompted large appropriations of Federal...

Status of timber utilization on the Pacific Coast.

Treesearch

John B. Grantham

1974-01-01

The need for additional sources of energy and raw material in the forest products industry enhances the opportunity to improve timber utilization by reducing logging residue. This is particularly true on the Pacific Coast where some 14 million tons of logging residue accumulate each year and where some 3 million tons of unused bark create a disposal problem at mills....

Mind the Gap...between Grad Skills and Employer Expectations

ERIC Educational Resources Information Center

Ebersole, John F.

2014-01-01

Much has been written in both the business and higher education press about the gap between today's jobs and the skills presented by those seeking work. The fact that U.S. Department of Labor statistics show 9.6 million people out of work with 4.8 million jobs still unfilled (August 2014) suggests a problem. However, little agreement exists…

Snapshots of Chinese Classrooms Illustrate Disparities

ERIC Educational Resources Information Center

Pultorak, Edward G.; Markle, Glenn C.

2008-01-01

In rural China today, only 0.2% have a college education. Since 1980, China has sustained the highest rate of growth in per-capita income in the world. From 1981 to 2001, the number of poor people living on less than $1 per day was reduced from 634 million to 211 million. The poverty problem, however, has not been solved. In 2005, a delegation of…

Optimizing the Disposition and Retrograde of United States Air Force Class VII Equipment from Afghanistan

DTIC Science & Technology

2014-03-27

1959). On a linear-programming, combinatorial approach to the traveling - salesman problem . Operations Research, 58-66. Daugherty, P. J., Myers, M. B...1 Problem Statement... Problem Statement As of 01 September 2013, the USAF is tracking 12,571 individual Class VII assets valued at $213.5 million for final disposition

Current status and future directions of the population control policies in Korea.

PubMed

Cho, N H; Seo, M H

1989-07-01

Recent changes in demographic and socioeconomic conditions in Korea are reviewed, as are population control policies so that future policy directions can be established. Major data sources include the 1988 National Fertility and Family Health Survey and the 1985 Population and Housing Census of NBOS, EPB. The Korean population increased from 25.0 million in 1960 to 42.4 million in 1989. Population growth rate declined from 3.0% per annum to l.0% at the same time. The total fertility rate went down from 6.0/women to 1.6, from 1960 to 1987. This was due to a family planning program and socioeconomic development. In the Sixth Five-Year Plan (1987-1991), the government changed the demographic goals to further reduce the population growth rate to 0.96% by 1991. The estimated 1987 population of 41.6 million should reach 43.2 million by 1991. Korea will face 3 major population problems: an increase of the elderly population, rapid urbanization and shortage of resources. Emigration programs have been carried out to relieve the pressure of population. For the last 29 years, rural to urban migration has existed. A national family planning program exists. 16.4 million acceptors have received contraception under this program. There are, however, a number of problems. Reduction in population growth will help the world food supply problem and the housing shortage. Energy use has grown. Population and environmental planning should work together. Goals should change from reduction of fertility to eliminating problems with contraceptive acceptance and use effectiveness. There should be a greater choice of methods of contraception. The government functions of the family planning program should be given over to private organizations. The family planning program should be integrated with public health programs. Acceptors should pay for their contraceptives. The family planning program should enlarge its realm of activities. The information, education, communication part of the program should be revised. Individual program activities should be evaluated. Appendix 1 presents new population projections for 1987-2020. Changes in composition of the population are given in table form in Appendix 2.

The state of science: violence and HIV infection in women.

PubMed

Manfrin-Ledet, Linda; Porche, Demetrius J

2003-01-01

Violence and human immunodeficiency virus (HIV) are two critical public health problems affecting the lives of millions of women today. The purpose of this article is to review the state of science that exists in linking the phenomena of violence and HIV infection in women. The history and scope of violence and HIV infection is presented. Theoretical models for the phenomena of violence and abuse against women and HIV risk behavior reduction are explored. The literature review consists of 44 research articles that examine risk factors for violence and HIV, violence associated with HIV/AIDS disclosure, history of violence and HIV/AIDS, forced or coercive sex and HIV/AIDS, and violence associated with HIV self-protection conduct. Implications for nursing practice and nursing research are presented.

Your Morals Depend on Language

PubMed Central

Costa, Albert; Foucart, Alice; Hayakawa, Sayuri; Aparici, Melina; Apesteguia, Jose; Heafner, Joy; Keysar, Boaz

2014-01-01

Should you sacrifice one man to save five? Whatever your answer, it should not depend on whether you were asked the question in your native language or a foreign tongue so long as you understood the problem. And yet here we report evidence that people using a foreign language make substantially more utilitarian decisions when faced with such moral dilemmas. We argue that this stems from the reduced emotional response elicited by the foreign language, consequently reducing the impact of intuitive emotional concerns. In general, we suggest that the increased psychological distance of using a foreign language induces utilitarianism. This shows that moral judgments can be heavily affected by an orthogonal property to moral principles, and importantly, one that is relevant to hundreds of millions of individuals on a daily basis. PMID:24760073

Effect of poverty on eye health and implications for nursing practice.

PubMed

Williamson, Swapna; Seewoodhary, Ramesh; Dampies, Lavona

2016-08-10

Poverty is a global issue that affects the health and quality of life of millions of people. It predisposes people to many health conditions, including sight loss or blindness as a result of the immune system becoming compromised. Blindness is common in areas of the world where there is extreme poverty. In the UK, poverty has become a major social issue, contributing to many health problems, including eye conditions. These eye conditions can result in sight loss if they are not managed effectively. Psychosocial care is an essential aspect of patient care, because poverty and sight loss are interrelated. Healthcare practitioners have a significant role in the management and prevention of blindness. Blindness caused by poverty is largely preventable, and health promotion is an important strategy in care management.

Managing Asthma in the Classroom

ERIC Educational Resources Information Center

Hamm, Ellen M.

2004-01-01

Asthma is the most common chronic disease of childhood, affecting nearly 5 million children under the age of 18. Children with asthma account for 3 million hospital visits and 200,000 hospitalizations yearly. This adds up to an estimated $2 billion annually in health care costs (American Academy of Pediatrics, 1999). A child with asthma has three…

American Youth: A Statistical Snapshot.

ERIC Educational Resources Information Center

Wetzel, James R.

This document presents a statistics snapshot of young people, aged 15 to 24 years. It provides a broad overview of trends documenting the direction of changes in social behavior and economic circumstances. The projected decline in the total number of youth from 43 million in 1980 to 35 million in 1995 will affect marriage and childbearing…

Meta-Analysis of Chemical and Non-Chemical Stressors Affecting Childhood Obesity

EPA Science Inventory

Childhood obesity is not a new notion but it is a growing epidemic around the world. There is approximately 42 million children under 5 around the world who are considered overweight or obese and here in the united states that is 12.7 million children between the ages of 2 and 19...

The Million Dollar Difference and 21st Century Teaching Skills Project

ERIC Educational Resources Information Center

Moon, Debi; Moolenaar-Wirsiy, Pamela

2008-01-01

With a limited budget, but a critical need to develop 21st century marketplace skills, Georgia Perimeter College (GPC) developed the Million Dollar Difference Campaign. Focusing on how quality instruction affects retention and student outcomes, GPC re-energized a 1000-faculty workforce in one year through a series of innovative teaching…

Solving LP Relaxations of Large-Scale Precedence Constrained Problems

NASA Astrophysics Data System (ADS)

Bienstock, Daniel; Zuckerberg, Mark

We describe new algorithms for solving linear programming relaxations of very large precedence constrained production scheduling problems. We present theory that motivates a new set of algorithmic ideas that can be employed on a wide range of problems; on data sets arising in the mining industry our algorithms prove effective on problems with many millions of variables and constraints, obtaining provably optimal solutions in a few minutes of computation.

Incidence of health problems associated with tattooed skin: a nation-wide survey in German-speaking countries.

PubMed

Klügl, Ines; Hiller, Karl-Anton; Landthaler, Michael; Bäumler, Wolfgang

2010-08-01

Millions of people are tattooed. However, the frequency of health problems is unknown. We performed an Internet survey in German-speaking countries. The provenance of tattooed participants (n = 3,411) was evenly distributed in Germany. The participants had many (28%; >4) and large tattoos (36%; >or=900 cm(2)). After tattooing, the people described skin problems (67.5%) or systemic reactions (6.6%). Four weeks after tattooing, 9% still had health problems. Six percent reported persistent health problems due to the tattoo, of which females (7.3%) were more frequently concerned than males (4.2%). Colored tattoos provoked more short-term skin (p = 0.003) or systemic (p = 0.0001) reactions than black tattoos. Also the size of tattoos and the age at the time of tattooing play a significant role in many health problems. Our results show that millions of people in the Western world supposedly have transient or persisting health problems after tattooing. Owing to the large number and size of the tattoos, tattooists inject several grams of tattoo colorants into the skin, which partly spread in the human body and stay for a lifetime. The latter might cause additional health problems in the long term. Copyright 2010 S. Karger AG, Basel.

Analysis of Algorithms: Coping with Hard Problems

ERIC Educational Resources Information Center

Kolata, Gina Bari

1974-01-01

Although today's computers can perform as many as one million operations per second, there are many problems that are still too large to be solved in a straightforward manner. Recent work indicates that many approximate solutions are useful and more efficient than exact solutions. (Author/RH)

Some Considerations on the Problem of Non-Steady State Traffic Flow Optimization

DOT National Transportation Integrated Search

2007-01-01

Poor traffic signal timing accounts for an estimated 10 percent of all traffic delay about 300 million vehicle-hours on major roadways alone. Americans agree that this is a problem: one U.S. Department of Transportation (DOT) survey found tha...

Fortifying baladi bread in Egypt: reaching more than 50 million people through the subsidy program.

PubMed

Elhakim, Nadine; Laillou, Arnaud; El Nakeeb, Anwar; Yacoub, Rukia; Shehata, Magdy

2012-12-01

Micronutrient deficiencies, especially iron-deficiency anemia, are a public health problem in Egypt, where anemia rates almost doubled in the years from 2000 to 2005. In 2008, the Government of Egypt began implementation of a 5-year national program to fortify with iron and folic acid the wheat flour used in baking subsidized baladi bread, the staple food consumed by a majority of low- income groups. To project the achievements of this national Wheat Flour Fortification Program. This paper describes the program, estimates the production of fortified flour and consumption of fortified bread, and identifies program challenges and sustainability issues. Through the national Wheat Flour Fortification Program, ferrous sulfate and folic acid are now added to all wheat flour produced under the national Food Subsidy Program. Up to 50 million Egyptians nationwide are now consuming quality-assured fortified baladi bread on a daily basis. In 2011, 6.5 million MT of fortified wheat flour was produced by 143 participating public- and private-sector mills. Political changes in Egypt in 2011 did not seem to affect the program; the new leadership in the Ministry of Supply and Internal Trade remains committed to fortification of wheat flour. The daily intake of approximately 12 mg of iron and 600 microg of folic acid through the consumption of baladi bread suggests that the impact of the program on the prevention and reduction of iron and folate deficiencies among the Egyptian population could be significant; the results of an end-line survey are pending.

Estimating and mapping the population at risk of sleeping sickness.

PubMed

Simarro, Pere P; Cecchi, Giuliano; Franco, José R; Paone, Massimo; Diarra, Abdoulaye; Ruiz-Postigo, José Antonio; Fèvre, Eric M; Mattioli, Raffaele C; Jannin, Jean G

2012-01-01

Human African trypanosomiasis (HAT), also known as sleeping sickness, persists as a public health problem in several sub-Saharan countries. Evidence-based, spatially explicit estimates of population at risk are needed to inform planning and implementation of field interventions, monitor disease trends, raise awareness and support advocacy. Comprehensive, geo-referenced epidemiological records from HAT-affected countries were combined with human population layers to map five categories of risk, ranging from "very high" to "very low," and to estimate the corresponding at-risk population. Approximately 70 million people distributed over a surface of 1.55 million km(2) are estimated to be at different levels of risk of contracting HAT. Trypanosoma brucei gambiense accounts for 82.2% of the population at risk, the remaining 17.8% being at risk of infection from T. b. rhodesiense. Twenty-one million people live in areas classified as moderate to very high risk, where more than 1 HAT case per 10,000 inhabitants per annum is reported. Updated estimates of the population at risk of sleeping sickness were made, based on quantitative information on the reported cases and the geographic distribution of human population. Due to substantial methodological differences, it is not possible to make direct comparisons with previous figures for at-risk population. By contrast, it will be possible to explore trends in the future. The presented maps of different HAT risk levels will help to develop site-specific strategies for control and surveillance, and to monitor progress achieved by ongoing efforts aimed at the elimination of sleeping sickness.

Current Status and Problems in Certification of Sustainable Forest Management in China

NASA Astrophysics Data System (ADS)

Zhao, Jingzhu; Xie, Dongming; Wang, Danyin; Deng, Hongbing

2011-12-01

Forest certification is a mechanism involving the regulation of trade of forest products in order to protect forest resources and improve forest management. Although China had a late start in adopting this process, the country has made good progress in recent years. As of July 31, 2009, 17 forest management enterprises and more than one million hectares of forests in China have been certified by the Forest Stewardship Council (FSC). Several major factors affect forest certification in China. The first set is institutional in nature. Forest management in China is based on centralized national plans and therefore lacks flexibility. A second factor is public awareness. The importance and value of forest certification are not widely understood and thus consumers do not make informed choices regarding certified forest products. The third major factor is the cost of certification. Together these factors have constrained the development of China's forest certification efforts. However, the process does have great potential. According to preliminary calculations, if 50% of China's commercial forests were certified, the economic cost of forest certification would range from US0.66-86.63 million while the economic benefits for the forestry business sector could exceed US150 million. With continuing progress in forest management practices and the development of international trade in forest products, it becomes important to improve the forest certification process in China. This can be achieved by improving the forest management system, constructing and perfecting market access mechanisms for certificated forest products, and increasing public awareness of environmental protection, forest certification, and their interrelationship.

Current status and problems in certification of sustainable forest management in China.

PubMed

Zhao, Jingzhu; Xie, Dongming; Wang, Danyin; Deng, Hongbing

2011-12-01

Forest certification is a mechanism involving the regulation of trade of forest products in order to protect forest resources and improve forest management. Although China had a late start in adopting this process, the country has made good progress in recent years. As of July 31, 2009, 17 forest management enterprises and more than one million hectares of forests in China have been certified by the Forest Stewardship Council (FSC). Several major factors affect forest certification in China. The first set is institutional in nature. Forest management in China is based on centralized national plans and therefore lacks flexibility. A second factor is public awareness. The importance and value of forest certification are not widely understood and thus consumers do not make informed choices regarding certified forest products. The third major factor is the cost of certification. Together these factors have constrained the development of China's forest certification efforts. However, the process does have great potential. According to preliminary calculations, if 50% of China's commercial forests were certified, the economic cost of forest certification would range from US$0.66-86.63 million while the economic benefits for the forestry business sector could exceed US$150 million. With continuing progress in forest management practices and the development of international trade in forest products, it becomes important to improve the forest certification process in China. This can be achieved by improving the forest management system, constructing and perfecting market access mechanisms for certificated forest products, and increasing public awareness of environmental protection, forest certification, and their interrelationship.

Heart Disease Affects Women of All Ages

MedlinePlus

Skip Navigation Bar Home Current Issue Past Issues Heart Disease Affects Women of All Ages Past Issues / Winter ... weeks of a heart attack. For Women with Heart Disease: About 6 million American women have coronary heart ...

Evaluation of an operating MOD-OA 200 kW wind turbine blade

NASA Technical Reports Server (NTRS)

Donham, R. E.

1979-01-01

Operating loads and structural damage were monitored during operation of the MOD-OA electric generating system. The turbine was damaged locally between stations 48 and 125 after 2.8 million rotations. Loads due to degraded yaw stiffness and fretting at rib station 48 were identified as primary to this distress. The repaired blades operated an additional 4.8 million rotations without problems.

CGBVS-DNN: Prediction of Compound-protein Interactions Based on Deep Learning.

PubMed

Hamanaka, Masatoshi; Taneishi, Kei; Iwata, Hiroaki; Ye, Jun; Pei, Jianguo; Hou, Jinlong; Okuno, Yasushi

2017-01-01

Computational prediction of compound-protein interactions (CPIs) is of great importance for drug design as the first step in in-silico screening. We previously proposed chemical genomics-based virtual screening (CGBVS), which predicts CPIs by using a support vector machine (SVM). However, the CGBVS has problems when training using more than a million datasets of CPIs since SVMs require an exponential increase in the calculation time and computer memory. To solve this problem, we propose the CGBVS-DNN, in which we use deep neural networks, a kind of deep learning technique, instead of the SVM. Deep learning does not require learning all input data at once because the network can be trained with small mini-batches. Experimental results show that the CGBVS-DNN outperformed the original CGBVS with a quarter million CPIs. Results of cross-validation show that the accuracy of the CGBVS-DNN reaches up to 98.2 % (σ<0.01) with 4 million CPIs. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

An Examination of Physical and Mental Health Problems of the Homeless.

ERIC Educational Resources Information Center

Solarz, Andrea; Mowbray, Carol

Homelessness is a significant social problem in the United States and it has been estimated that there may be as many as 2.5 million homeless people in this country today. For these people, poverty, substance abuse, and harsh living conditions may further contribute to the development of physical and mental health problems. A study was conducted…

Rare Disorders and Diseases

ERIC Educational Resources Information Center

Umlauf, Mary; Monaco, Jana; FitzZaland, Mary; FitzZaland, Richard; Novitsky, Scott

2008-01-01

According to the National Organization for Rare Disorders (NORD), a rare or "orphan" disease affects fewer than 200,000 people in the United States. There are more than 6,000 rare disorders that, taken together, affect approximately 25 million Americans. "Exceptional Parent" ("EP") recognizes that when a disorder affects a child or adult, it…

Neglected Tropical Diseases in Sub-Saharan Africa: Review of Their Prevalence, Distribution, and Disease Burden

PubMed Central

Hotez, Peter J.; Kamath, Aruna

2009-01-01

The neglected tropical diseases (NTDs) are the most common conditions affecting the poorest 500 million people living in sub-Saharan Africa (SSA), and together produce a burden of disease that may be equivalent to up to one-half of SSA's malaria disease burden and more than double that caused by tuberculosis. Approximately 85% of the NTD disease burden results from helminth infections. Hookworm infection occurs in almost half of SSA's poorest people, including 40–50 million school-aged children and 7 million pregnant women in whom it is a leading cause of anemia. Schistosomiasis is the second most prevalent NTD after hookworm (192 million cases), accounting for 93% of the world's number of cases and possibly associated with increased horizontal transmission of HIV/AIDS. Lymphatic filariasis (46–51 million cases) and onchocerciasis (37 million cases) are also widespread in SSA, each disease representing a significant cause of disability and reduction in the region's agricultural productivity. There is a dearth of information on Africa's non-helminth NTDs. The protozoan infections, human African trypanosomiasis and visceral leishmaniasis, affect almost 100,000 people, primarily in areas of conflict in SSA where they cause high mortality, and where trachoma is the most prevalent bacterial NTD (30 million cases). However, there are little or no data on some very important protozoan infections, e.g., amebiasis and toxoplasmosis; bacterial infections, e.g., typhoid fever and non-typhoidal salmonellosis, the tick-borne bacterial zoonoses, and non-tuberculosis mycobaterial infections; and arboviral infections. Thus, the overall burden of Africa's NTDs may be severely underestimated. A full assessment is an important step for disease control priorities, particularly in Nigeria and the Democratic Republic of Congo, where the greatest number of NTDs may occur. PMID:19707588

Asthma and Environment Fact Sheet for Parents and Schools. Revised

ERIC Educational Resources Information Center

Healthy Schools Network, Inc., 2012

2012-01-01

Important facts about asthma and the environment include: (1) Asthma has reached epidemic proportions in the United States, affecting about 25 million people of all ages and races, including about 7 million children; (2) Nearly one in 10 school-aged children has asthma, and the percentage of children with asthma is rising more rapidly in…

40 CFR 63.7533 - Can I use efficiency credits earned from implementation of energy conservation measures to comply...

Code of Federal Regulations, 2014 CFR

2014-07-01

... the implementation plan for efficiency credits to the Administrator for review and approval no later... level adjusted by applying the efficiency credits earned, lb per million Btu steam output (or lb per MWh) for the affected boiler. Em = Emissions measured during the performance test, lb per million Btu steam...

40 CFR 63.7533 - Can I use efficiency credits earned from implementation of energy conservation measures to comply...

Code of Federal Regulations, 2013 CFR

2013-07-01

... the implementation plan for efficiency credits to the Administrator for review and approval no later... level adjusted by applying the efficiency credits earned, lb per million Btu steam output (or lb per MWh) for the affected boiler. Em = Emissions measured during the performance test, lb per million Btu steam...

Education Data in Conflict-Affected Countries: The Fifth Failure?

ERIC Educational Resources Information Center

Montjourides, Patrick

2013-01-01

Poor-quality, or completely absent, data deny millions of children the right to an education. This is often the case in conflict-ridden areas. The 2011 Education for All Global Monitoring Report (UNESCO 2011b) identified four failures that are holding back progress in education and damaging millions of children's lives: failures of protection,…

Isolation of dihydroatemisinic acid from the artemisia annua l. by-product by combining Ultrasound-assisted extraction with response surface methodology

USDA-ARS?s Scientific Manuscript database

Malaria is one of the world’s most important parasitic diseases, affecting 300-500 million people worldwide and killing more than one million per year. Artemisinin is currently the only raw material for the production of artemisinin combination therapies (ACT), the only medicine that cures drug-resi...

Childhood Obesity Prevention and Treatment Research (COPTR): Interventions Addressing Multiple Influences in Childhood and Adolescent Obesity

PubMed Central

Pratt, Charlotte A.; Boyington, Josephine; Esposito, Layla; Pemberton, Victoria L.; Bonds, Denise; Kelley, Melinda; Yang, Song; Murray, David; Stevens, June

2018-01-01

Obesity is a major public health problem affecting more than 12 million (~17%)U.S. children. The scientific community agrees that tackling this problem must begin in childhood to reduce risk of subsequent development of cardiovascular diseases and other chronic diseases. The Childhood Obesity Prevention and Treatment Research (COPTR) Consortium, initiated by the National Institutes of Health (NIH), is conducting intervention studies to prevent obesity in pre-schoolers and treat overweight or obese 7–13 year olds. Four randomized controlled trials plan to enroll a total of 1,700 children and adolescents (~ 50% female, 70% minorities), and are testing innovative multi-level and multi-component interventions in multiple settings involving primary care physicians, parks and recreational centers, family advocates, and schools. For all the studies, the primary outcome measure is body mass index; secondary outcomes, moderators and mediators of intervention include diet, physical activity, home and neighborhood influences, and psychosocial factors. COPTR is being conducted collaboratively among four participating field centers, a coordinating center, and NIH project offices. PMID:23999502

Awareness, practices, and health problems of backpackers traveling during flooding in Thailand during 2011.

PubMed

Piyaphanee, Watcharapong; Olanwijitwong, Jutarmas; Kusolsuk, Teera; Silachamroon, Udomsak

2012-09-01

During late 2011, Thailand experienced its worst flooding in 50 years with over 4.6 million people directly affected. During the flooding we conducted a cross sectional survey of backpackers in the Khao San Road area of Bangkok to determine awareness, practices, and their incidence of health problems during the flooding. A total of 422 subjects completed questionnaires which were analyzed. Seventy percent were European and 12.3% were North American. The overall median age was 27 years and the median stay in Thailand was 22 days. Most of the backpackers were aware of the flooding in Thailand; some had sought travel health information prior to their trip from various sources including the internet, their family physician or a travel clinic. However, even in travel clinics specific health advice related to flooding, such as leptospirosis risk/prevention, was rarely given to travelers. Fifteen point four percent of subjects (65/422) had come into contact with floodwater; 30.8% of those (20/65) washed their feet/legs afterward. Our findings indicate most backpackers were inadequately aware of potential health hazards, such as leptospirosis, during the floods.

Brain Tissue Oxygen Monitoring and the Intersection of Brain and Lung: A Comprehensive Review.

PubMed

Ngwenya, Laura B; Burke, John F; Manley, Geoffrey T

2016-09-01

Traumatic brain injury is a problem that affects millions of Americans yearly and for which there is no definitive treatment that improves outcome. Continuous brain tissue oxygen (PbtO2 ) monitoring is a complement to traditional brain monitoring techniques, such as intracranial pressure and cerebral perfusion pressure. PbtO2 monitoring has not yet become a clinical standard of care, due to several unresolved questions. In this review, we discuss the rationale and technology of PbtO2 monitoring. We review the literature, both historic and current, and show that continuous PbtO2 monitoring is feasible and useful in patient management. PbtO2 numbers reflect cerebral blood flow and oxygen diffusion. Thus, continuous monitoring of PbtO2 yields important information about both the brain and the lung. The preclinical and clinical studies demonstrating these findings are discussed. In this review, we demonstrate that patient management in a PbtO2 -directed fashion is not the sole answer to the problem of treating traumatic brain injury but is an important adjunct to the armamentarium of multimodal neuromonitoring. Copyright © 2016 by Daedalus Enterprises.

The asbestos cancer epidemic.

PubMed Central

LaDou, Joseph

2004-01-01

The asbestos cancer epidemic may take as many as 10 million lives before asbestos is banned worldwide and exposures are brought to an end. In many developed countries, in the most affected age groups, mesothelioma may account for 1% of all deaths. In addition to mesotheliomas, 5-7% of all lung cancers can be attributed to occupational exposures to asbestos. The asbestos cancer epidemic would have been largely preventable if the World Health Organization (WHO) and the International Labor Organization (ILO) had responded early and responsibly. The WHO was late in recognizing the epidemic and failed to act decisively after it was well under way. The WHO and the ILO continue to fail to address the problem of asbestos mining, manufacturing, and use and world trade of a known human carcinogen. Part of the problem is that the WHO and the ILO have allowed organizations such as the International Commission on Occupational Health (ICOH) and other asbestos industry advocates to manipulate them and to distort scientific evidence. The global asbestos cancer epidemic is a story of monumental failure to protect the public health. PMID:14998741

Nanotechnology and pharmaceutical inhalation aerosols.

PubMed

Patel, A R; Vavia, P R

2007-02-01

Pharmaceutical inhalation aerosols have been playing a crucial role in the health and well being of millions of people throughout the world for many years. The technology's continual advancement, the ease of use and the more desirable pulmonary-rather-than-needle delivery for systemic drugs has increased the attraction for the pharmaceutical aerosol in recent years. But administration of drugs by the pulmonary route is technically challenging because oral deposition can be high, and variations in inhalation technique can affect the quantity of drug delivered to the lungs. Recent advances in nanotechnology, particularly drug delivery field have encouraged formulation scientists to expand their reach in solving tricky problems related to drug delivery. Moreover, application of nanotechnology to aerosol science has opened up a new category of pharmaceutical aerosols (collectively known as nanoenabled-aerosols) with added advantages and effectiveness. In this review, some of the latest approaches of nano-enabled aerosol drug delivery system (including nano-suspension, trojan particles, bioadhesive nanoparticles and smart particle aerosols) that can be employed successfully to overcome problems of conventional aerosol systems have been introduced.

A Biogeotechnical engineering approach to Combat Desertification

NASA Astrophysics Data System (ADS)

Chang, I.; Im, J.; Cho, G. C.; Lee, S. J.

2016-12-01

The acceleration of global warming is not only inducing rising sea levels and abnormal climate problems, but also geotechnical hazards such as desertification. Recently, 30% of Earth's dry land has been affected by desertification, and approximately 850 million people are suffering due to famine, poverty, and hygiene problems induced by desertification. Global warming and unsustainable land development are known to be major triggers promoting desertification. Numerous global agencies and companies are thus contributing to anti-desertification movements. However, tree planting alone is not an ideal solution given that it takes approximately 2 3 years for stabilization. It is thus imperative to develop innovative technology that can promote vegetation growth and improve soil erosion resistance. In this study, a unique soil treatment and anti-desertification method is developed using microbial biopolymers. Biopolymers can effectively strengthen soil and improve durability. In particular, anionic-hydrophilic biopolymers delay water evaporation, thereby retaining a higher soil moisture condition compared to non-treated soil. Results of this study show that microbial biopolymer treatment is highly effective in improving both vegetation growth (3 times faster) and soil erosion resistance (less than 2%), compared to untreated earth surfaces.

Parental HIV/AIDS status and death, and children's psychological wellbeing.

PubMed

Doku, Paul Narh

2009-11-24

Ghana has an estimated one million orphans, 250,000 are due to AIDS parental deaths. This is the first study that examined the impact of parental HIV/AIDS status and death on the mental health of children in Ghana. In a cross-sectional survey, 4 groups of 200 children (children whose parents died of AIDS, children whose parents died of causes other than AIDS, children living with parents infected with HIV/AIDS, and non-orphaned children whose parents are not known to be infected with HIV/AIDS) aged between 10 and 19 were interviewed on their hyperactivity, emotional, conduct, and peer problems using the Strengths and Difficulties Questionnaire. Children whose parents died of AIDS showed very high levels of peer problems [F (3,196) = 7.34, p < .001] whilst both orphaned groups scored similarly high on conduct problems [F (3, 196) = 14.85, p < .001]. Hyperactivity showed no difference and was very low in the entire sample. Emotional problems were very high in all the groups except among the non-orphaned children [F (3, 196) = 5.10, p < .001]. Orphans and children living with parents infected with HIV/AIDS are at heightened risks for emotional and behavioural disorders and that efforts to address problems in children affected by HIV/AIDS must focus on both groups of children. Parallel to this, researchers should see these findings as generated hypotheses (rather than conclusions) calling for further exploration of specific causal linkages between HIV/AIDS and children's mental health, using more rigorous research tools and designs.

Quality end-of-life care: A global perspective

PubMed Central

Singer, Peter A; Bowman, Kerry W

2002-01-01

Background Quality end-of-life care has emerged as an important concept in industrialized countries. Discussion We argue quality end-of-life care should be seen as a global public health and health systems problem. It is a global problem because 85 % of the 56 million deaths worldwide that occur annually are in developing countries. It is a public health problem because of the number of people it affects, directly and indirectly, in terms of the well being of loved ones, and the large-scale, population based nature of some possible interventions. It is a health systems problem because one of its main features is the need for better information on quality end-of-life care. We examine the context of end-of-life care, including the epidemiology of death and cross-cultural considerations. Although there are examples of success, we could not identify systematic data on capacity for delivering quality end-of-life care in developing countries. We also address a possible objection to improving end-of-life care in developing countries; many deaths are preventable and reduction of avoidable deaths should be the focus of attention. Conclusions We make three recommendations: (1) reinforce the recasting of quality end-of-life care as a global public health and health systems problem; (2) strengthen capacity to deliver quality end-of-life care; and (3) develop improved strategies to acquire information about the quality of end-of-life care. PMID:12139768

Medical device problem reporting for the betterment of healthcare.

PubMed

1998-08-01

Given that there are nearly 5,000 individual classes of medical devices, tens of thousands of medical device suppliers, and millions of healthcare providers around the world, device-related problems are bound to happen. But effective problem reporting can help reduce or eliminate many of these problems--not only within an institution, but also potentially around the world. In this article, we trace the problem reporting process from its beginnings in the hospital to its global impact in making critical information available throughout the healthcare community.

Russia's population sink.

PubMed

Nelson, T

1996-01-01

Russia's public health problems, which are a result in part of uncontrolled development, are a lesson for developing countries. Trends in births and deaths in Russia indicate that as socioeconomic conditions declined in recent years, the death rate increased. During 1992-93 the death rate increased from 12.1 per 1000 population to 14.5, with 75% of the increase due to cardiovascular disease, accidents, murder, suicide, and alcohol poisoning. Quality of health care was given as one reason for the high cardiovascular disease rate that included deaths due to even mild heart attacks. 20-30% of deaths are attributed to pollution. 75% of rivers and lakes in the former Soviet Union are considered unfit for drinking, and 50% of tap water is unsanitary. An estimated 15% of Russia's land area is considered to be an ecological disaster zone. Births declined from a peak of 2.5 million in 1987 to 1.4 million in 1994. During this same period deaths increased from 1.5 million to 2.3 million. In 1994 deaths exceeded births by 880,000. Life expectancy declined from 65 to 57 years for men and from 75 years to 71 years for women. Infant mortality is rising. 11% of newborns had birth defects, and 60% showed evidence of allergies or vitamin D deficiencies. The death rate during pregnancy was 50 per 1000 births, and 75% of Russian women experienced complications during pregnancy. Women's health in the reproductive years was compromised by gynecological infections. A survey in 1992 revealed that 75% of Russian women gave insufficient income as a reason for reduced childbearing. The social conditions in Russia and the former Soviet republics reflect a lack of confidence in the future. Demographic trends are affected by a complex set of factors including economic collapse, economic change and uncertainty, inadequate health care, and poor environmental conditions. These changes occurred during the mid-1980s and before the collapse of the Soviet Union in 1991.

Modelling the healthcare costs of skin cancer in South Africa.

PubMed

Gordon, Louisa G; Elliott, Thomas M; Wright, Caradee Y; Deghaye, Nicola; Visser, Willie

2016-04-02

Skin cancer is a growing public health problem in South Africa due to its high ambient ultraviolet radiation environment. The purpose of this study was to estimate the annual health system costs of cutaneous melanoma, squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) in South Africa, incorporating both the public and private sectors. A cost-of-illness study was used to measure the economic burden of skin cancer and a 'bottom-up' micro-costing approach. Clinicians provided data on the patterns of care and treatments while national costing reports and clinician fees provided cost estimates. The mean costs per melanoma and per SCC/BCC were extrapolated to estimate national costs using published incidence data and official population statistics. One-way and probabilistic sensitivity analyses were undertaken to address the uncertainty of the parameters used in the model. The estimated total annual cost of treating skin cancers in South Africa were ZAR 92.4 million (2015) (or US$15.7 million). Sensitivity analyses showed that the total costs could vary between ZAR 89.7 to 94.6 million (US$15.2 to $16.1 million) when melanoma-related variables were changed and between ZAR 78.4 to 113.5 million ($13.3 to $19.3 million) when non-melanoma-related variables were changed. The primary drivers of overall costs were the cost of excisions, follow-up care, radical lymph node dissection, cryotherapy and radiation therapy. The cost of managing skin cancer in South Africa is sizable. Since skin cancer is largely preventable through improvements to sun-protection awareness and skin cancer prevention programs, this study highlights these healthcare resources could be used for other pressing public health problems in South Africa.

Disasters related to droughts and public health - a review of the scientific literature.

PubMed

Alpino, Tais Ariza; de Sena, Aderita Ricarda Martins; de Freitas, Carlos Machado

2016-03-01

In Brazil, the history of droughts has been marked by constant social and health tragedies, with estimates of up to 3 million deaths from the early 19th century until the late 20th century. There is a record of nearly 32,000 events related to the above and more than 96 million people were affected between 1991 and 2010. Although droughts have historically brought disasters to Brazil, which was noted in the scientific expeditions of Arthur Neiva and Belisario Penna that documented these droughts, there have not been many studies on them. The objective of this paper is to present a revision of the scientific articles related to droughts and public health. The following databases were used: PubMed, the Preparation and Response to Disasters Portal from BVS and the Capes Periodical Portal. The descriptors drought and health were used to search titles and summaries of articles in English, Portuguese and Spanish. Among the repercussions related to health that were discovered: malnutrition and nutritional deficiencies, mental health problems, issues relating to water and air quality and commitments made concerning access to health services. As there is a trend for more intense droughts and a scarcity of water until 2030, there is an urgent need for more research and studies in these areas.

JPRS Report, Soviet Union, EKO: Economics & Organization of Industrial Production.

DTIC Science & Technology

1988-03-28

us to expect a quick solution to the problem. Therefore it would be expedient to recall how they solved a similar problem with soil protection technology...on millions of hectares they introduced soil protection tech- nology and industry assimilated a complex of machines for carrying it out. The land

Investigating Environmental Concerns and Health Issues in Clarksville, Tennessee

ERIC Educational Resources Information Center

Rainey, Shirley A.; Jones, Robert Emmet

2005-01-01

Environmental degradation is a serious problem for millions of people who are unjustly exposed to environmental conditions that threaten their everyday survival. A growing body of research shows race and class as significant predictors to exposure to environmental hazards and associated health problems. Presented are perceptions of environmental…

The influence of calorie labeling on food orders and consumption: A review of the literature1

PubMed Central

Kiszko, Kamila M.; Martinez, Olivia D.; Abrams, Courtney; Elbel, Brian

2014-01-01

Obesity is a challenging public health problem that affects millions of Americans. Increasingly policy makers are seeking environmental and policy-based solutions to combat and prevent its serious health effects. Calorie labeling mandates, including the provision in the 2010 Patient Protection and Affordable Care Act that is set to begin in 2014, have been one of the most popular and most studied approaches. This review examines 31 studies published from January 1, 2007 through July 19, 2013. It builds on Harnack and French's 2008 review and assesses the evidence on the effectiveness of calorie labeling at the point of purchase. We find that, while there are some positive results reported from studies examining the effects of calorie labeling, overall the best designed studies (real world studies, with a comparison group) show that calorie labels do not have the desired effect in reducing total calories ordered at the population level. Moving forward, researchers should consider novel, more effective ways of presenting nutrition information, while keeping a focus on particular subgroups that may be differentially affected by nutrition policies. PMID:24760208

Pattern of the haemoglobinopathy in the endemic and nearby provinces in Thailand, a note from then GIS pattern.

PubMed

Wiwanitkit, Viroj

2011-11-01

In Thailand, high prevalence of haemoglobin disorders has been reported. Millions of Thai people suffer from these diseases. This problem affects not only public health but also the economy of the country. Carrier detection, genetic counselling and prenatal diagnosis should be encouraged. Most of the programmes have been launched to the endemic provinces in the southern part of northeastern region of Thailand. However, due to the recent industrialisation in Thailand, the migration of the Thai population affects the pattern of haemoglobin disorder in this area. Here, the author performs a spatial analysis by Geographical Information System (GIS) using ArcExplorer Program on the database of the recorded prevalence of haemoglobin disorder in the endemic area and nearby provinces. The drift of the high prevalence from the central endemic area to the nearby provinces can be seen and support the migration effect of the population. Of interest, this observation can support the recent report on the rising prevalence of haemoglobin disorders in the non-endemic area of Thailand.

Are megacities viable? A cautionary tale from Mexico City.

PubMed

Ezcurra, E; Mazari-hiriart, M

1996-01-01

This article describes the poor environmental and living conditions in Mexico City due to its huge size. Mexico City's size is a challenge to sustainability, and the outcome is unknown. Mexico City and the geographic basin surrounding it included about 18.5 million population in 1995. The basin and surrounding volcanic ranges include nine major environmental zones. Urban growth followed four stages. Different cultures applied different solutions to water supply problems. The basin shifted from self-sufficiency to reliance on 31% of supplies from external watersheds. The water table is declining and canals are polluted. Irrigated agriculture is disappearing. There is an average water deficit of over 800 million cubic meters per year. Mexico City is actually sinking due to groundwater exploitation. There is bacterial contamination of wells due to improper seals. About 75% of the population has access to wastewater treatment and sanitation, but sewage treatment plants operate at under 50% efficiency and treat only about 7% of the total wastewater. Atmospheric pollution from suspended particles has been a problem for decades. Ozone was the most significant air contaminant in 1994. Lead was the most harmful pollutant in 1986. Air pollutants may be the source of submucosal inflammations. Industrial areas are contaminated with suspended particles and sulfur dioxide. High traffic areas have high carbon monoxide levels. Atmospheric pollution has affected the quality of the rainwater. The city survives by importing food, energy, wood, water, building materials, and other products. The development model aims to improve quality of life. The city has been the center of political power since Aztec times, and its preeminent position forces government action. The author concludes that there are limits to urbanization, which the city is approaching rapidly.

Childhood and adult mortality from unintentional falls in India

PubMed Central

Jagnoor, Jagnoor; Suraweera, Wilson; Keay, Lisa; Ivers, Rebecca Q; Thakur, JS; Gururaj, Gopalkrishna

2011-01-01

Abstract Objective To estimate fall-related mortality by type of fall in India. Methods The authors analysed unintentional injury data from the ongoing Million Death Study from 2001–2003 using verbal autopsy and coding of all deaths in accordance with the International statistical classification of diseases and related health problems, tenth revision, in a nationally representative sample of 1.1 million homes throughout the country. Findings Falls accounted for 25% (2003/8023) of all deaths from unintentional injury and were the second leading cause of such deaths. An estimated 160 000 fall-related deaths occurred in India in 2005; of these, nearly 20 000 were in children aged 0–14 years. The unintentional-fall-related mortality rate (MR) per 100 000 population was 14.5 (99% confidence interval, CI: 13.7–15.4). Rates were similar for males and females at 14.9 (99% CI: 13.7–16.0) and 14.2 (99% CI: 13.1–15.4) per 100 000 population, respectively. People aged 70 years or older had the highest mortality rate from unintentional falls (MR: 271.2; 99% CI: 249.0–293.5), and the rate was higher among women (MR: 281; 99% CI: 249.7–311.3). Falls on the same level were the most common among older adults, whereas falls from heights were more common in younger age groups. Conclusion In India, unintentional falls are a major public health problem that disproportionately affects older women and children. The contexts in which these falls occur and the resulting morbidity and disability need to be better understood. In India there is an urgent need to develop, test and implement interventions aimed at preventing falls. PMID:22084511

[The dentist's role in the child abuse: diagnosis and report].

PubMed

Crespo, Manuela; Andrade, David; Alves, Ana La-Salete; Magalhães, Teresa

2011-12-01

Child Abuse is a frequent problem worldwide that surpasses ethnicity, religion, culture, economic and social classes. In the United States of America child protective services account, per year, over one million cases of child abuse or neglect. In Portugal, the incidence of the problem is unknown but each year thousands of abused children are accompanied by the Commissions for the Protection of Children and Youth at Risk. This abuse threatens children's physical, emotional and intellectual development, as well as their dignity, security, well-being and even their own lives. The body regions most frequently affected in physical abuse, are the cranium, neck and orofacial region, in fact, about 50% of the injuries arising from child abuse occur in the orofacial region. These data place the dentist in a privileged position to make the detection, diagnosis and report of child abuse. Therefore, these professionals must be prepared to recognize, diagnose and report their suspicions to the appropriate authorities, which play a key role in victims protection and criminal investigation. This review intends to stress the important role of the dentist in the detection, diagnosis and report of child abuse, systematizing child abuse risk factors and indicators essential to the intervention of these professionals. This problem's approach is multidisciplinary, involving particularly dentists, who must obtain continuing education and training in this area.

Forest management and the impact on water resources: A review of 13 countries

Treesearch

Pablo A. Garcia-Chevesich; Daniel G. Neary; David F. Scott; Teresa Reyna Benyon

2017-01-01

Trees have been around for more than 370 million years, and today there are about 80 thousand species of them, occupying 3.5 billion hectares worldwide, including 250 million ha of commercial plantations. While forests can provide tremendous environmental, social, and economic benefits to nations, they also affect the hydrologic cycle in different ways. As the demand...

Factors Affecting Adoption and Diffusion of Distance Education among Health Education Faculty

ERIC Educational Resources Information Center

Ball, James W.

2013-01-01

Background: In the past decade, distance education enrollment has become more common in colleges and universities, increasing from 1.6 million students in 1998 to an estimated 6.7 million in 2012. The purpose of this study was to identify which constructs in Rogers' (2003) diffusion of innovation theory are more likely to contribute to adoption…

Supporting Grieving Children in Early Childhood Programs

ERIC Educational Resources Information Center

Perkins, Kaarin D.; Mackey, Bonnie

2008-01-01

Approximately 2 million people die each year in the United States. If each individual death affects only five other people, there are close to 10 million people grieving a new death each year in this country. Children who have lost a loved one through death can be in very difficult situations. While they are attempting to cope with the shock and…

Women in the Military. More Military Jobs Can Be Opened under Current Statutes. Report to Congressional Requesters.

ERIC Educational Resources Information Center

General Accounting Office, Washington, DC. Div. of National Security and International Affairs.

A study determined how service policies implementing the combat exclusion provisions affect the number and assignment of military women and whether service procedures unrelated to the combat exclusion limit job opportunities for women. Based on the combat exclusion and related program needs, about 1.1 million of 2.2 million military jobs were…

Hope and Healing: A Caregiver's Guide to Helping Young Children Affected by Trauma

ERIC Educational Resources Information Center

Rice, Kathleen Fitzgerald; Groves, Betsy McAlister

2005-01-01

The U.S. Department of Health and Human Services reports that close to 1 million children a year are identified as victims of maltreatment. The National Clearinghouse of Child Abuse and Neglect estimates that between 3 and 10 million children a year witness the abuse of a parent or caregiver. In recent years, therapists, educators, and…

76 FR 12564 - Subsistence Management Regulations for Public Lands in Alaska-2011-12 and 2012-13 Subsistence...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-08

... economy or adversely affect an economic sector, productivity, jobs, the environment, or other units of the... do not result in an additional dollar benefit to the economy. However, we estimate that two million... the economy of $100 million or more, will not cause a major increase in costs or prices for consumers...

The relationship between chronic conditions and absenteeism and associated costs in Canada.

PubMed

Zhang, Wei; McLeod, Christopher; Koehoorn, Mieke

2016-09-01

This study aimed to measure and compare the relationship between chronic diseases and the number of absent workdays due to health problems and the associated costs among working Canadians. The study sample included respondents to the 2010 Canadian Community Health Survey between aged 15-75 years who reported employment in the past three months. Respondents reported their number of absent workdays due to health problems and chronic conditions. A negative binomial regression was used to estimate the incremental absent workdays associated with having a particular chronic condition (of 16 conditions), conditional on other chronic conditions and confounders. For each condition, we calculated the incremental number of absent workdays, the incremental productivity loss attributed to absenteeism per employee, and the overall productivity loss in the population. The final sample consisted of 28 678 respondents representing 15 468 788 employed Canadians. The average number of absent workdays due to health problems was 1.35 days over a 3-month period. The three conditions with the greatest association with absent workdays were mood disorders, heart disease, and bowel disorders. They were associated with 1.17, 0.81, and 0.80 additional absent workdays, respectively, compared to workers without this condition, holding other conditions and confounders at their means. At the national working population level, back problems (CAD$621 million), mood disorders (CAD$299 million) and migraine (CAD$245 million) accounted for the largest incremental productivity loss. Chronic conditions, especially mood disorders and back problems, are associated with substantial work productivity loss. The study findings can help policy-makers and employers prioritize their programs and resources aimed at reducing absenteeism among the working population with chronic conditions.

RIT2: responsible and susceptible gene for neurological and psychiatric disorders.

PubMed

Daneshmandpour, Yousef; Darvish, Hossein; Emamalizadeh, Babak

2018-06-02

RIT2 gene was recently introduced as a susceptibility gene in neurological disorders, a group of major problems in human society affecting millions of people worldwide. Several variants, including single nucleotide polymorphisms and CNVs, have been identified and studied in different populations. In this review, we have summarized the studies relevant to the RIT2 gene and its related disorders, including Parkinson's disease, schizophrenia, and autism. The protein product of RIT2 is a member of the Ras superfamily that plays important roles in many vital cellular functions, such as differentiation and survival. We have also investigated the protein network of the RIT2 protein and the diseases related to members of this network so as to obtain some clues for future studies by identifying the molecular pathophysiology of neurological disorders and revealing new possible disorders related to RIT2.

Bunion: Strengthening Foot Muscles to Reduce Pain and Improve Mobility.

PubMed

2016-07-01

Foot pain discourages physical activity, and less activity harms overall health. Bunion, extra bone and tissue at the base of the big toe, is a frequent cause of foot pain. More than 64 million Americans have bunions that can lead to painful walking. Bunions affect some 35% of women over the age of 65. Bunions can be removed by surgery, which can reduce pain and improve your ability to walk and exercise, but up to 15% of bunions return. Weak muscles may play a role in bunion-related pain and movement problems. In a review of prior research and commentary on this topic published in the July 2016 issue of JOSPT, the author identifies muscle-strengthening exercises that may help people with bunions. J Orthop Sports Phys Ther 2016;46(7):606. doi:10.2519/jospt.2016.0504.

Label-free photoacoustic microscopy of peripheral nerves

NASA Astrophysics Data System (ADS)

Matthews, Thomas Paul; Zhang, Chi; Yao, Da-Kang; Maslov, Konstantin; Wang, Lihong V.

2014-01-01

Peripheral neuropathy is a common neurological problem that affects millions of people worldwide. Diagnosis and treatment of this condition are often hindered by the difficulties in making objective, noninvasive measurements of nerve fibers. Photoacoustic microscopy (PAM) has the ability to obtain high resolution, specific images of peripheral nerves without exogenous contrast. We demonstrated the first proof-of-concept imaging of peripheral nerves using PAM. As validated by both standard histology and photoacoustic spectroscopy, the origin of photoacoustic signals is myelin, the primary source of lipids in the nerves. An extracted sciatic nerve sandwiched between two layers of chicken tissue was imaged by PAM to mimic the in vivo case. Ordered fibrous structures inside the nerve, caused by the bundles of myelin-coated axons, could be observed clearly. With further technical improvements, PAM can potentially be applied to monitor and diagnose peripheral neuropathies.

How do the effects of mutations add up?

NASA Astrophysics Data System (ADS)

Velenich, Andrea; Dai, Mingjie; Gore, Jeff

2011-03-01

Genetic mutations affect the fitness of any organism and provide the variability necessary for natural selection to occur. Given the fitness of a wild type organism and the fitness of mutants A and B which differ from the wild type by a single mutation, predicting the fitness of the double mutant AB is a fundamental problem with broad implications in many fields, from evolutionary theory to medicine. Analysis of millions of double gene knockouts in yeast reveals that, on average, the fitness of AB is the product of the fitness of A and the fitness of B. However, most pairs of mutations deviate from this mean behavior in a way that challenges existing theoretical models. We propose a natural generalization of the geometric Fisher's model which accommodates the experimentally observed features and allows us to characterize the fitness landscape of yeast.

The Population Biology and Transmission Dynamics of Loa loa.

PubMed

Whittaker, Charles; Walker, Martin; Pion, Sébastien D S; Chesnais, Cédric B; Boussinesq, Michel; Basáñez, María-Gloria

2018-04-01

Endemic to Central Africa, loiasis - or African eye worm (caused by the filarial nematode Loa loa) - affects more than 10 million people. Despite causing ocular and systemic symptoms, it has typically been considered a benign condition, only of public health relevance because it impedes mass drug administration-based interventions against onchocerciasis and lymphatic filariasis in co-endemic areas. Recent research has challenged this conception, demonstrating excess mortality associated with high levels of infection, implying that loiasis warrants attention as an intrinsic public health problem. This review summarises available information on the key parasitological, entomological, and epidemiological characteristics of the infection and argues for the mobilisation of resources to control the disease, and the development of a mathematical transmission model to guide deployment of interventions. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

Sleep Apnea Facts

MedlinePlus

... Apnea Facts Sleep Apnea Links Sleep Apnea Facts Sleep apnea affects up to 18 million Americans The condition was ... member is the first to notice signs of sleep apnea in someone with the ... diagnosed. The condition affects about 4 percent of middle-aged men and ...

Disruption of key NADH-binding pocket residues of the Mycobacterium tuberculosis InhA affects DD-CoA binding ability.

PubMed

Shaw, Daniel J; Robb, Kirsty; Vetter, Beatrice V; Tong, Madeline; Molle, Virginie; Hunt, Neil T; Hoskisson, Paul A

2017-07-05

Tuberculosis (TB) is a global health problem that affects over 10 million people. There is an urgent need to develop novel antimicrobial therapies to combat TB. To achieve this, a thorough understanding of key validated drug targets is required. The enoyl reductase InhA, responsible for synthesis of essential mycolic acids in the mycobacterial cell wall, is the target for the frontline anti-TB drug isoniazid. To better understand the activity of this protein a series of mutants, targeted to the NADH co-factor binding pocket were created. Residues P193 and W222 comprise a series of hydrophobic residues surrounding the cofactor binding site and mutation of both residues negatively affect InhA function. Construction of an M155A mutant of InhA results in increased affinity for NADH and DD-CoA turnover but with a reduction in V max for DD-CoA, impairing overall activity. This suggests that NADH-binding geometry of InhA likely permits long-range interactions between residues in the NADH-binding pocket to facilitate substrate turnover in the DD-CoA binding region of the protein. Understanding the precise details of substrate binding and turnover in InhA and how this may affect protein-protein interactions may facilitate the development of improved inhibitors enabling the development of novel anti-TB drugs.

Philanthro-metrics: Mining multi-million-dollar gifts

PubMed Central

2017-01-01

The Million Dollar List (MDL, online at http://www.milliondollarlist.org) is a compilation of publicly announced charitable donations of $1 million or more from across the United States since 2000; as of December 2016, the database contains close to 80,000 gifts made by U.S. individuals, corporations, foundations, and other grant-making nonprofit organizations. This paper discusses the unique value of the Million Dollar List and provides unique insights to key questions such as: How does distance affect giving? How do networks impact million-dollar-plus gifts? Understanding the geospatial and temporal dimensions of philanthropy can assist researchers and policymakers to better understand the role of private funding in innovation and discovery. Moreover, the results from the paper emphasize the importance of philanthropy for fueling research and development in science, the arts, environment, and health. The paper also includes the limitations of the presented analyses and promising future work. PMID:28552937

Philanthro-metrics: Mining multi-million-dollar gifts.

PubMed

Osili, Una O; Ackerman, Jacqueline; Kong, Chin Hua; Light, Robert P; Börner, Katy

2017-01-01

The Million Dollar List (MDL, online at http://www.milliondollarlist.org) is a compilation of publicly announced charitable donations of $1 million or more from across the United States since 2000; as of December 2016, the database contains close to 80,000 gifts made by U.S. individuals, corporations, foundations, and other grant-making nonprofit organizations. This paper discusses the unique value of the Million Dollar List and provides unique insights to key questions such as: How does distance affect giving? How do networks impact million-dollar-plus gifts? Understanding the geospatial and temporal dimensions of philanthropy can assist researchers and policymakers to better understand the role of private funding in innovation and discovery. Moreover, the results from the paper emphasize the importance of philanthropy for fueling research and development in science, the arts, environment, and health. The paper also includes the limitations of the presented analyses and promising future work.

Flooding experience at Veracruz: not only a natural disaster

NASA Astrophysics Data System (ADS)

Welsh-Rodriguez, C. M.; Nava Bringas, M.; Ochoa Martinez, C.; Local; regional impacts of global change

2013-05-01

The Veracruz state lies on the middle of the Gulf of Mexico in Mexican Republic; has a surface of 72815 Km2 represent almost the 4% of Mexico. Due to the complex topography, the rainfall, runoff and the extreme weather the 33% of Mexican water goes trough Veracruz, and every year the presence of tropical depressions, tropical storms and hurricanes impacts on the habitants of Veracruz (7.5 millions). For Veracruz the Sierra Madre is the natural border on the West and on the East the Gulf of Mexico. It is located from 17°10' to 23°38' (N) and between 93° to 99° (W). We will try to get the find out the primary information source for the floods on 2005 and 20010 and correlate with the laws on environment and civil protection for Veracruz. In 1999 a tropical depression more than 200 000 persons and more than 20 died, in 2005 Stan hurricane affected more than a million persons but no one died. In 2010 the effects of hurricane Karl were similar but a few days after the tropical depression Mathew affected 150 000 persons more and 15 people died. The patterns of people habitat in Veracruz since middle of XX century follows the oil industry develop at south east Mexico, so the risk increased as the population density increased, that's a critical reason to concluded that is not only cause - effect issue on Veracruz. So if the extreme events increase as consequence of the climate variability and climate change the vulnerability on this region will not be address in prevention policies, and the future scenario on adaptation will be a deep complex problem to solve from all perspectives.Reported impactst; Extreme events. Data from Veracruz Government.

Utilization and application of wet potato processing coproducts for finishing cattle.

PubMed

Nelson, M L

2010-04-01

Wet coproducts fed to beef cattle include processing coproducts of the fruit, vegetable, juice, and brewing industries. Considerations for their utilization in beef cattle diets include quantity available, feeding value, quality of animal products produced, economics (e.g., transportation of water), storage and preservation, consumer perception, nuisance concerns, contaminants, and interactions with other diet ingredients. Potato (Solanum tuberosum) coproducts from processing for frozen food products may be quantitatively most important because the 11.3 million t of potatoes (fresh weight) processed in the United States and Canada in 2008 resulted in an estimated 4.3 million t (as-is basis) of coproduct. Chemical composition and feeding value of potato coproducts depends on the coproduct type. The names of coproducts vary among potato processors and some processors combine the different coproducts into one product commonly called slurry. The 4 main potato coproducts are 1) potato peels; 2) screen solids (small potatoes and pieces); 3) fried product (fries, hash browns, batter, crumbles); and 4) material from the water recovery systems (oxidation ditch, belt solids, filter cake). The coproducts, except the fried products, ensile rapidly, reaching pH 5 in 7 d or less. Dry matter content varies from 10 to 30% and on a DM basis varies in CP (5 to 27%), starch (3 to 56%), NDF (4 to 41%), and ether extract (3 to 37%) content among potato coproducts. Type of coproduct and frying greatly affect the energy value (0.6 to 1.6 Mcal of NE(g)/kg of DM). Composition, quality, and shelf life of beef was not affected by potato coproduct feeding in contrast to perceptions of some purveyors and chefs. Potato coproducts are quantitatively important energy sources in beef cattle diets, which, in turn, solve a potentially massive disposal problem for the food processing industry.

Flooding and Flood Management

USGS Publications Warehouse

Brooks, K.N.; Fallon, J.D.; Lorenz, D.L.; Stark, J.R.; Menard, Jason; Easter, K.W.; Perry, Jim

2011-01-01

Floods result in great human disasters globally and nationally, causing an average of $4 billion of damages each year in the United States. Minnesota has its share of floods and flood damages, and the state has awarded nearly $278 million to local units of government for flood mitigation projects through its Flood Hazard Mitigation Grant Program. Since 1995, flood mitigation in the Red River Valley has exceeded $146 million. Considerable local and state funding has been provided to manage and mitigate problems of excess stormwater in urban areas, flooding of farmlands, and flood damages at road crossings. The cumulative costs involved with floods and flood mitigation in Minnesota are not known precisely, but it is safe to conclude that flood mitigation is a costly business. This chapter begins with a description of floods in Minneosta to provide examples and contrasts across the state. Background material is presented to provide a basic understanding of floods and flood processes, predication, and management and mitigation. Methods of analyzing and characterizing floods are presented because they affect how we respond to flooding and can influence relevant practices. The understanding and perceptions of floods and flooding commonly differ among those who work in flood forecasting, flood protection, or water resource mamnagement and citizens and businesses affected by floods. These differences can become magnified following a major flood, pointing to the need for better understanding of flooding as well as common language to describe flood risks and the uncertainty associated with determining such risks. Expectations of accurate and timely flood forecasts and our ability to control floods do not always match reality. Striving for clarity is important in formulating policies that can help avoid recurring flood damages and costs.

Dynamic simulation solves process control problem in Oman

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1998-11-16

A dynamic simulation study solved the process control problems for a Saih Rawl, Oman, gas compressor station operated by Petroleum Development of Oman (PDO). PDO encountered persistent compressor failure that caused frequent facility shutdowns, oil production deferment, and gas flaring. It commissioned MSE (Consultants) Ltd., U.K., to find a solution for the problem. Saih Rawl, about 40 km from Qarn Alam, produces oil and associated gas from a large number of low and high-pressure wells. Oil and gas are separated in three separators. The oil is pumped to Qarn Alam for treatment and export. Associated gas is compressed in twomore » parallel trains. Train K-1115 is a 350,000 standard cu m/day, four-stage reciprocating compressor driven by a fixed-speed electric motor. Train K-1120 is a 1 million standard cu m/day, four-stage reciprocating compressor driven by a fixed-speed electric motor. Train K-1120 is a 1 million standard cu m/day, four-stage centrifugal compressor driven by a variable-speed motor. The paper describes tripping and surging problems with the gas compressor and the control simplifications that solved the problem.« less

Drinking Water Sodium and Elevated Blood Pressure of Healthy Pregnant Women in Salinity-Affected Coastal Areas.

PubMed

Scheelbeek, Pauline F D; Khan, Aneire E; Mojumder, Sontosh; Elliott, Paul; Vineis, Paolo

2016-08-01

Coastal areas in Southeast Asia are experiencing high sodium concentrations in drinking water sources that are commonly consumed by local populations. Salinity problems caused by episodic cyclones and subsequent seawater inundations are likely (partly) related to climate change and further exacerbated by changes in upstream river flow and local land-use activities. Dietary (food) sodium plays an important role in the global burden of hypertensive disease. It remains unknown, however, if sodium in drinking water-rather than food-has similar effects on blood pressure and disease risk. In this study, we examined the effect of drinking water sodium on blood pressure of pregnant women: increases in blood pressure in this group could severely affect maternal and fetal health. Data on blood pressure, drinking water source, and personal, lifestyle, and environmental confounders was obtained from 701 normotensive pregnant women residing in coastal Bangladesh. Generalized linear mixed regression models were used to investigate association of systolic and diastolic blood pressure of these-otherwise healthy-women with their water source. After adjustment for confounders, drinkers of tube well and pond water (high saline sources) were found to have significantly higher average systolic (+4.85 and +3.62 mm Hg) and diastolic (+2.30 and +1.72 mm Hg) blood pressures than rainwater drinkers. Drinking water salinity problems are expected to exacerbate in the future, putting millions of coastal people-including pregnant women-at increased risk of hypertension and associated diseases. There is an urgent need to further explore the health risks associated to this understudied environmental health problem and feasibility of possible adaptation strategies. © 2016 American Heart Association, Inc.

Psychedelics and mental health: a population study.

PubMed

Krebs, Teri S; Johansen, Pål-Ørjan

2013-01-01

The classical serotonergic psychedelics LSD, psilocybin, mescaline are not known to cause brain damage and are regarded as non-addictive. Clinical studies do not suggest that psychedelics cause long-term mental health problems. Psychedelics have been used in the Americas for thousands of years. Over 30 million people currently living in the US have used LSD, psilocybin, or mescaline. To evaluate the association between the lifetime use of psychedelics and current mental health in the adult population. Data drawn from years 2001 to 2004 of the National Survey on Drug Use and Health consisted of 130,152 respondents, randomly selected to be representative of the adult population in the United States. Standardized screening measures for past year mental health included serious psychological distress (K6 scale), mental health treatment (inpatient, outpatient, medication, needed but did not receive), symptoms of eight psychiatric disorders (panic disorder, major depressive episode, mania, social phobia, general anxiety disorder, agoraphobia, posttraumatic stress disorder, and non-affective psychosis), and seven specific symptoms of non-affective psychosis. We calculated weighted odds ratios by multivariate logistic regression controlling for a range of sociodemographic variables, use of illicit drugs, risk taking behavior, and exposure to traumatic events. 21,967 respondents (13.4% weighted) reported lifetime psychedelic use. There were no significant associations between lifetime use of any psychedelics, lifetime use of specific psychedelics (LSD, psilocybin, mescaline, peyote), or past year use of LSD and increased rate of any of the mental health outcomes. Rather, in several cases psychedelic use was associated with lower rate of mental health problems. We did not find use of psychedelics to be an independent risk factor for mental health problems.

Psychedelics and Mental Health: A Population Study

PubMed Central

Krebs, Teri S.; Johansen, Pål-Ørjan

2013-01-01

Background The classical serotonergic psychedelics LSD, psilocybin, mescaline are not known to cause brain damage and are regarded as non-addictive. Clinical studies do not suggest that psychedelics cause long-term mental health problems. Psychedelics have been used in the Americas for thousands of years. Over 30 million people currently living in the US have used LSD, psilocybin, or mescaline. Objective To evaluate the association between the lifetime use of psychedelics and current mental health in the adult population. Method Data drawn from years 2001 to 2004 of the National Survey on Drug Use and Health consisted of 130,152 respondents, randomly selected to be representative of the adult population in the United States. Standardized screening measures for past year mental health included serious psychological distress (K6 scale), mental health treatment (inpatient, outpatient, medication, needed but did not receive), symptoms of eight psychiatric disorders (panic disorder, major depressive episode, mania, social phobia, general anxiety disorder, agoraphobia, posttraumatic stress disorder, and non-affective psychosis), and seven specific symptoms of non-affective psychosis. We calculated weighted odds ratios by multivariate logistic regression controlling for a range of sociodemographic variables, use of illicit drugs, risk taking behavior, and exposure to traumatic events. Results 21,967 respondents (13.4% weighted) reported lifetime psychedelic use. There were no significant associations between lifetime use of any psychedelics, lifetime use of specific psychedelics (LSD, psilocybin, mescaline, peyote), or past year use of LSD and increased rate of any of the mental health outcomes. Rather, in several cases psychedelic use was associated with lower rate of mental health problems. Conclusion We did not find use of psychedelics to be an independent risk factor for mental health problems. PMID:23976938

JPRS Report, China

DTIC Science & Technology

1989-06-14

Wensheng are still single and unmarried . Zhang Hanzhi [4545 0698 0037], the third woman in this group, came from a well-known family. Her father, Zhang...also a "senior translator" originally, who later married Qiao Guanhua [0829 0385 5478]. The Background for Criticizing Lin [Biao], Confucius, and...hopes on reform of the ownership system instead. But can the problem of millions who have jobs but are "unem- ployed" and millions who are still

Playing the Ponies: A $5 Million Embezzlement Case

ERIC Educational Resources Information Center

Howe, Martha A.; Malgwi, Charles A.

2006-01-01

Fraud is a pervasive problem, and educating future business leaders, managers, and auditors about fraud is one way to attack the problem. This instructional fraud case chronicles the actual details surrounding a major embezzlement at a regional high school (RHS) that culminated in long federal and state prison sentences for the school's treasurer.…

Adolescent Substance Use: America's #1 Public Health Problem

ERIC Educational Resources Information Center

National Center on Addiction and Substance Abuse at Columbia University, 2011

2011-01-01

This report finds that adolescent smoking, drinking, misusing prescription drugs and using illegal drugs is, by any measure, a public health problem of epidemic proportion, presenting clear and present danger to millions of America's teenagers and severe and expensive long-range consequences for the entire population. This report is a wake-up call…

The Public School Infrastructure Problem: Deteriorating Buildings and Deferred Maintenance

ERIC Educational Resources Information Center

Hunter, Richard C.

2009-01-01

The deterioration of public school buildings is more prevalent in large cities that, because of funding shortfalls, have deferred maintenance and require huge sums to bring their buildings up to acceptable standards. Cities such as New York will require approximately $680 million to address the problem of deferred maintenance for needed painting,…

Persisting Mental Health Problems among AIDS-Orphaned Children in South Africa

ERIC Educational Resources Information Center

Cluver, Lucie D.; Orkin, Mark; Gardner, Frances; Boyes, Mark E.

2012-01-01

Background: By 2008, 12 million children in sub-Saharan Africa were orphaned by AIDS. Cross-sectional studies show psychological problems for AIDS-orphaned children, but until now no longitudinal study has explored enduring psychological effects of AIDS-orphanhood in the developing world. Methods: A 4-year longitudinal follow-up of AIDS-orphaned…

Chile: Political and Economic Conditions and U.S. Relations

DTIC Science & Technology

2009-01-12

Demonstrations ........................................................................................................ 5 Mapuche Activism...is the root problem.18 ’ # Confrontation with the Mapuche population has been a persistent problem for the Bachelet Administration...The Mapuche are Chile’s largest indigenous group and comprise approximately 4% of the population or 660,000 of Chile’s 16.5 million citizens.19 They

Earthquakes Threaten Many American Schools

ERIC Educational Resources Information Center

Bailey, Nancy E.

2010-01-01

Millions of U.S. children attend schools that are not safe from earthquakes, even though they are in earthquake-prone zones. Several cities and states have worked to identify and repair unsafe buildings, but many others have done little or nothing to fix the problem. The reasons for ignoring the problem include political and financial ones, but…

Refugees of the Syrian Civil War: Impact on Reemerging Infections, Health Services, and Biosecurity in Turkey.

PubMed

Doganay, Mehmet; Demiraslan, Hayati

2016-01-01

After the Arab Spring uprising, Syria descended into a civil war in 2011. By March 2016, the United Nations reported that 13.5 million Syrians required humanitarian assistance, including 6.6 million internally displaced persons and more than 4.8 million refugees outside of Syria. Turkey is currently hosting the largest number of Syrian refugees-more than 2.7 million. A limited number of refugees are living in camps settled around the border, and others are spread throughout Turkey. This explosive and unexpected increase in the Syrian population in Turkey has had several negative impacts on health and social determinants. The overload of healthcare facilities has led to shortages in childhood immunization programs, drugs, and access to clean water and food supplies. According to Ministry of Health data, more than 7.5 million Syrians were examined at outpatient clinics, and 299,240 were hospitalized; most of those hospitalized were injured and wounded victims who require and have been occupying intensive care units. The refugees generally live in crowded and unsanitary conditions, which may lead to the spread of respiratory, skin, gastrointestinal, and genital system infections. Currently, measles, poliomyelitis, leishmaniasis, and multidrug-resistant tuberculosis are the reemerging infections being most frequently recorded. Multidrug-resistant gram-negative bacterial infections seem to be an increasing problem in gunshot or surgical wounds. Hepatitis A, malaria, and varicella have been seen with a high incidence among the refugees. There are many problems waiting to be resolved for health and living standards in Turkey.

Population, petroleum, and politics: Mexico at the crossroads. Pt. 1.

PubMed

Gallagher, C F

1980-01-01

By 1975 Mexico's estimated population was 59.6 million, the median age, 16.2 years, lower than any major country. This growth has been accompanied by massive internal migrations and urbanization. By 1970 the previously pronatalist policy of the government began to shift to one more favorable to family planning. The proximity to the U.S. has made Mexico's history subject to neocolonialism. Until the 1938 nationalization of oil, few of Mexico's decisions were her own. Mexico began to prosper after World War 2, and from 1945-72 the annual growth rate averaged 6%. Mortality decreased while birth rates remained high. Changes in policy have led to dramatic decreases in the birth rate. In 1973 only 11% of all married women were using contraceptives; by 1976 21% were. The 1977-78 birth rate was about 37/1000. Mexico now has a master population plan calling for reduction of the rate of natural increase to 2.5% in 1982 and 1.8% in 1988. The budget or the National Family Planning Coordination was raised in 1979 from 450 million to 700 million pesos (about $32 million). The problem facing Mexico is how to provide employment and education for the more than 40 million people to be born in the next 2 decades. With the increase of women in the work force, 1,200.000 jobs will be needed by the beginning of the 1990s. New oil deposits and the wealth from them are being seen as the solution that will provide the development resources to overcome population problems.

Elimination of neglected tropical diseases in the South-East Asia Region of the World Health Organization.

PubMed

Narain, Jai P; Dash, A P; Parnell, B; Bhattacharya, S K; Barua, S; Bhatia, R; Savioli, L

2010-03-01

The neglected tropical diseases (NTDs), which affect the very poor, pose a major public health problem in the South-East Asia Region of the World Health Organization (WHO). Although more than a dozen NTDs affect the region, over the past five years four of them in particular - leprosy, lymphatic filariasis, visceral leishmaniasis (kala-azar) and yaws - have been targeted for elimination. These four were selected for a number of reasons. First, they affect the WHO South-East Asia Region disproportionately. For example, every year around 67% of all new leprosy cases and 60% of all new cases of visceral leishmaniasis worldwide occur in countries of the region, where as many as 850 million inhabitants are at risk of contracting lymphatic filariasis. In addition, several epidemiological, technological and historical factors that are unique to the region make each of these four diseases amenable to elimination. Safe and effective tools and interventions to achieve these targets are available and concerted efforts to scale them up, singly or in an integrated manner, are likely to lead to success. The World Health Assembly and the WHO Regional Committee, through a series of resolutions, have already expressed regional and global commitments for the elimination of these diseases as public health problems. Such action is expected to have a quick and dramatic impact on poverty reduction and to contribute to the achievement of the Millennium Development Goals. This paper reviews the policy rationale for disease control in the WHO South-East Asia Region, the progress made so far, the lessons learnt along the way, and the remaining challenges and opportunities.

An investigation of surface and crown fire dynamics in shrub fuels

Treesearch

Jesse Sandoval Lozano

2011-01-01

Fires burn large areas in California and around the world annually. California experiences numerous wildland fires that affect the lives of thousands of citizens every year. In 2000 the U.S. census bureau reported that 33.8 million people resided in California. The last census in 2010 showed California population had grown to 37.3 million people. As a consequence of...

VLCT-13: A commercial transport for the 21st Century

NASA Technical Reports Server (NTRS)

Beal, Pamela; Sowels, Terri; Takahashi, Hitoshi; Cotton, Matt; Balanon, Will; Parayo, Manuel

1993-01-01

The growth of the Pacific Rim market has spurred airframers to begin feasibility studies of a large commercial transport. By the year 2001, 30 million travelers are expected to travel the Transpacific. A transport capable of hauling 800 PAX and 30,000 pounds of cargo, 7,000 nm is of specific interest. Special problems associated with this design are configuration, landing gear, passenger safety, airport compatibility, and engine thrust. A group of students at the California Polytechnic State University at San Luis Obispo developed a very large commercial transport, VLCT-13, conventional looking design which is both comfortable and economical. Passenger comfort includes seat pitches of 34 in and 40 in, width's of 23 in and 25 in, respectfully, and a 27 ft diameter cross section. A direct operating cost of 2.3 cents per passenger per seat-mile is estimated for this airplane design. The airplane market price is estimated to be $195 million 1993 dollars based on an aircraft take off weight of 1.4 million pounds. The problems associated with the VLCT-13 are discussed and possible solutions are presented.

Vitamin A--fortified vegetable oil exported from Malaysia and Indonesia can significantly contribute to vitamin A intake worldwide.

PubMed

Laillou, Arnaud; Panagides, Dora; Garrett, Greg S; Moench-Pfanner, Regina

2013-06-01

Vitamin A deficiency is a public health problem worldwide, affecting approximately 190 million preschool-aged children and 19.1 million pregnant women. Fortification of vegetable oils with vitamin A is an effective, low-cost technology to improve vitamin A intake. To examine the potential contribution of fortification of vegetable oils with vitamin A in Indonesia and Malaysia to increasing vitamin A consumption in these two countries and in countries to which oil is exported. Detailed interviews were administered and a desk review was conducted. We also estimated potential vitamin A intakes from fortified vegetable oil. Malaysia and Indonesia are two of the largest producers and exporters of vegetable oil. Fortification of vegetable oil in both countries has the potential to be used as a tool for control of vitamin A deficiency. Both countries have the capacity to export fortified vegetable oil. Vegetable oil fortified at a level of 45 IU/g could provide 18.8% of the Estimated Average Requirement (EAR) for an Ethiopian woman, 30.9% and 46.9% of the EAR for a Bangladeshi child and woman, respectively, and 17.5% of the EAR for a Cambodian woman. Although concerns about obesity are valid, fortification of existing vegetable oil supplies does not promote overconsumption of oil but rather promotes consumption of vegetable oil of higher nutrient quality. Fortifying vegetable oil on a large scale in Malaysia and Indonesia can reach millions of people globally, including children less than 5 years old. The levels of fortification used are far from reaching the Tolerable Upper Intake Level (UL). Vegetable oil fortification has the potential to become a global public health intervention strategy.

Changing climate in a pre-impact world: a multi-proxy paleotemperature reconstruction across the last million years of the Cretaceous

NASA Astrophysics Data System (ADS)

Woelders, L.; Vellekoop, J.; Reichart, G. J.; de Nooijer, L. J.; Sluijs, A.; Peterse, F.; Claeys, P. F.; Speijer, R. P.

2015-12-01

Climate instability during the last million years of the Cretaceous (67-66 Ma) is still poorly documented and not well understood. One of the reasons for this is that in deep time, different proxies are likely to yield different temperatures. This is because the application of calibrations based on present day temperature proxy relationships is affected by source organism evolution, differences in ocean chemistry and non-analogue processes. Only by combining temperature estimates derived from different, independent proxies, the problems with individual proxies can be cancelled out. A quantitative, multi-proxy temperature record from the latest Cretaceous therefore may provide a better insight in climate changes across this time interval. For such a multi-proxy research, sediments are required that yield both well-preserved foraminiferal calcite as well as organic biomarkers. Very few sites are known to provide such sedimentary records, but ODP Leg 174AX Site Bass River (New Jersey Shelf) has proven to be an excellent archive for paleotemperature reconstructions for the Cretaceous and Paleogene. We here present a multi-proxy, quantitative paleotemperature reconstruction of the last million years of the Cretaceous of the Bass River core. Benthic and planktic foraminiferal Mg/Ca and δ18O were determined, as well as the organic geochemical sea surface temperature proxy TEX86. This resulted in a unique coupled surface and bottom water temperature record of the latest Cretaceous. Our data suggest a ~2-6 ˚C bottom water warming and a ~4-6 ˚C surface water warming approximately 300 kyr before the Cretaceous-Paleogene boundary, followed by a cooling trend across the boundary. This warming event appears to coincide with the main phase of the Deccan Traps eruptions and therefore probably represents a global event.

A thought on the integration of poverty relief with family planning.

PubMed

Yang, K

1997-01-01

This article discusses the relationship between population growth and poverty in China, the issue of overpopulation in poor areas, and the need for programs that integrate population control with economic development. The number of Chinese living in poverty declined from about 250 million in 1978 to 80 million in 1993. In March 1994, the government initiated a poverty relief program that aimed to eliminate all poverty by 2001. By 1995, the number of poor declined to 65 million. The causes of poverty are numerous, but include overpopulation. Over the decades, demographic trends in poor areas reveal higher fertility, lower mortality, and higher growth. Poverty appears to be concentrated in 18 provinces and autonomous regions. Poor areas have higher rates of early marriage, early childbirth, and multiple children. Poor areas also have higher rates of disabilities and disease and lower levels of education. Poor areas have double the national percentage of illiterates. Many people living in poor areas are disadvantaged by poor transportation, remote locations, backward production methods, and a lack of a social security system. Scientific knowledge about contraception and quality child care are difficult to diffuse in poor areas. The size of the population denominator directly affects per capita income and per capita grain production. Increases in population put pressure on investment resources for production and development. A larger work force adds to the problem of unemployment. A large population size puts pressure on arable land. Poor areas need a better educated population. Sustainable development requires fertility decline. Integrated family planning programs popularize slogans such as "stabilize grain yield, increase income, and control population growth." Integrated programs have had variable success. Countermeasures must be taken to prevent the association of large families with wealth. Leadership is essential.

Children of Chernobyl: A psycho-social empowerment project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kane, M.S.

The focus of this research has been to design and implement a social action project, using a Freirian Methodology for popular mental health among the victims of the 1986 Chernobyl nuclear meltown disaster living in Belarus. Although Chernobyl is in the Ukraine, only 35 kilometers from Kiev, 70% of the 50 million curies of radiation from the 1986 Chernobyl meltdown fell on the Republic of Belarus. This continues to directly affect 2.4 million of the total population of 10 million people. These people, 800,000 of whom are children, still live in the radiated zones. They live with the knowledge thatmore » the food, the water, and the ground are slowly poisoning them through continued and ongoing exposure to radiation. While there has been some significant research on the medical effects of the disaster in the Ukraine, much more research needs to be done in Belarus. Very little research or treatment has responded to the emotional, mental health and psychosocial impacts of the disaster on individuals, families and communities. Following the introduction to the problem, a rationale for a new paradigm in Mental Health Treatment is presented in a chapter titled Liberation Psychology'. This chapter integrates fields of psychology, psychotherapy, social work, education, and community organization from a Freirian perspective. The Social Action Project is outlined and described in specific detail. The Social Action Project has led to medical, computer and school supplies being sent to Belarus. Workshops and training have been designed and implemented. Texts and manuals have been translated and published. Further, there is documentation of a joint conceptualization and design of this Children of Chernobyl' project with signed letters of agreement and a report of a fact finding mission to Belaraus. The Social Action Project is then evaluated with Future Planning discussed in the conclusion.« less

Global causes of blindness and distance vision impairment 1990-2020: a systematic review and meta-analysis.

PubMed

Flaxman, Seth R; Bourne, Rupert R A; Resnikoff, Serge; Ackland, Peter; Braithwaite, Tasanee; Cicinelli, Maria V; Das, Aditi; Jonas, Jost B; Keeffe, Jill; Kempen, John H; Leasher, Janet; Limburg, Hans; Naidoo, Kovin; Pesudovs, Konrad; Silvester, Alex; Stevens, Gretchen A; Tahhan, Nina; Wong, Tien Y; Taylor, Hugh R

2017-12-01

Contemporary data for causes of vision impairment and blindness form an important basis of recommendations in public health policies. Refreshment of the Global Vision Database with recently published data sources permitted modelling of cause of vision loss data from 1990 to 2015, further disaggregation by cause, and forecasts to 2020. In this systematic review and meta-analysis, we analysed published and unpublished population-based data for the causes of vision impairment and blindness from 1980 to 2014. We identified population-based studies published before July 8, 2014, by searching online databases with no language restrictions (MEDLINE from Jan 1, 1946, and Embase from Jan 1, 1974, and the WHO Library Database). We fitted a series of regression models to estimate the proportion of moderate or severe vision impairment (defined as presenting visual acuity of <6/18 but ≥3/60 in the better eye) and blindness (presenting visual acuity of <3/60 in the better eye) by cause, age, region, and year. We identified 288 studies of 3 983 541 participants contributing data from 98 countries. Among the global population with moderate or severe vision impairment in 2015 (216·6 million [80% uncertainty interval 98·5 million to 359·1 million]), the leading causes were uncorrected refractive error (116·3 million [49·4 million to 202·1 million]), cataract (52·6 million [18·2 million to 109·6 million]), age-related macular degeneration (8·4 million [0·9 million to 29·5 million]), glaucoma (4·0 million [0·6 million to 13·3 million]), and diabetic retinopathy (2·6 million [0·2 million to 9·9 million]). Among the global population who were blind in 2015 (36·0 million [12·9 million to 65·4 million]), the leading causes were cataract (12·6 million [3·4 million to 28·7 million]), uncorrected refractive error (7·4 million [2·4 million to 14·8 million]), and glaucoma (2·9 million [0·4 million to 9·9 million]). By 2020, among the global population with moderate or severe vision impairment (237·1 million [101·5 million to 399·0 million]), the number of people affected by uncorrected refractive error is anticipated to rise to 127·7 million (51·0 million to 225·3 million), by cataract to 57·1 million (17·9 million to 124·1 million), by age-related macular degeneration to 8·8 million (0·8 million to 32·1 million), by glaucoma to 4·5 million (0·5 million to 15·4 million), and by diabetic retinopathy to 3·2 million (0·2 million to 12·9 million). By 2020, among the global population who are blind (38·5 million [13·2 million to 70·9 million]), the number of patients blind because of cataract is anticipated to rise to 13·4 million (3·3 million to 31·6 million), because of uncorrected refractive error to 8·0 million (2·5 million to 16·3 million), and because of glaucoma to 3·2 million (0·4 million to 11·0 million). Cataract and uncorrected refractive error combined contributed to 55% of blindness and 77% of vision impairment in adults aged 50 years and older in 2015. World regions varied markedly in the causes of blindness and vision impairment in this age group, with a low prevalence of cataract (<22% for blindness and 14·1-15·9% for vision impairment) and a high prevalence of age-related macular degeneration (>14% of blindness) as causes in the high-income subregions. Blindness and vision impairment at all ages in 2015 due to diabetic retinopathy (odds ratio 2·52 [1·48-3·73]) and cataract (1·21 [1·17-1·25]) were more common among women than among men, whereas blindness and vision impairment due to glaucoma (0·71 [0·57-0·86]) and corneal opacity (0·54 [0·43-0·66]) were more common among men than among women, with no sex difference related to age-related macular degeneration (0·91 [0·70-1·14]). The number of people affected by the common causes of vision loss has increased substantially as the population increases and ages. Preventable vision loss due to cataract (reversible with surgery) and refractive error (reversible with spectacle correction) continue to cause most cases of blindness and moderate or severe vision impairment in adults aged 50 years and older. A large scale-up of eye care provision to cope with the increasing numbers is needed to address avoidable vision loss. Brien Holden Vision Institute. Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved.

A natural experiment of social network formation and dynamics.

PubMed

Phan, Tuan Q; Airoldi, Edoardo M

2015-05-26

Social networks affect many aspects of life, including the spread of diseases, the diffusion of information, the workers' productivity, and consumers' behavior. Little is known, however, about how these networks form and change. Estimating causal effects and mechanisms that drive social network formation and dynamics is challenging because of the complexity of engineering social relations in a controlled environment, endogeneity between network structure and individual characteristics, and the lack of time-resolved data about individuals' behavior. We leverage data from a sample of 1.5 million college students on Facebook, who wrote more than 630 million messages and 590 million posts over 4 years, to design a long-term natural experiment of friendship formation and social dynamics in the aftermath of a natural disaster. The analysis shows that affected individuals are more likely to strengthen interactions, while maintaining the same number of friends as unaffected individuals. Our findings suggest that the formation of social relationships may serve as a coping mechanism to deal with high-stress situations and build resilience in communities.

A natural experiment of social network formation and dynamics

PubMed Central

Phan, Tuan Q.; Airoldi, Edoardo M.

2015-01-01

Social networks affect many aspects of life, including the spread of diseases, the diffusion of information, the workers' productivity, and consumers' behavior. Little is known, however, about how these networks form and change. Estimating causal effects and mechanisms that drive social network formation and dynamics is challenging because of the complexity of engineering social relations in a controlled environment, endogeneity between network structure and individual characteristics, and the lack of time-resolved data about individuals' behavior. We leverage data from a sample of 1.5 million college students on Facebook, who wrote more than 630 million messages and 590 million posts over 4 years, to design a long-term natural experiment of friendship formation and social dynamics in the aftermath of a natural disaster. The analysis shows that affected individuals are more likely to strengthen interactions, while maintaining the same number of friends as unaffected individuals. Our findings suggest that the formation of social relationships may serve as a coping mechanism to deal with high-stress situations and build resilience in communities. PMID:25964337

[Pediculus capitis in schoolchildren of the urban area of Nuevo León, México: Analyses of associated factors].

PubMed

Molina-Garza, Zinnia J; Galaviz-Silva, Lucio

2017-09-01

Pediculosis capitis is a recurring problem affecting 6 to 12 millions of children annually; there are no epidemiological data on this subject in the state of Nuevo León, and there are few in México. Therefore, new contributions are needed to design control strategies based on factors that may predispose to head lice infestation. To determine the prevalence of Pediculus capitis in primary school children and to evaluate risk factors and individual or socioeconomic characteristics statistically associated with infestation. We included 840 schoolchildren from six municipalities after parents and children signed an informed consent. Ectoparasites were collected from infested children using a finetoothed comb. Participants were interviewed using a questionnaire on individual and socioeconomic variables including age, gender, education, hair characteristics, overcrowding, and siblings with pediculosis, among others. The overall prevalence of head lice in schoolchildren was 28% (235/840), the highest prevalence was among girls (33.7%, 140/417), and children from the fifth grade (10-11 years old) were the most affected (6.2%; 52/840). Female gender, long hair and the father's education level were significantly associated with P. capitis. Our results showed that the P. capitis prevalence in Nuevo León is one of the highest in Mexico, that it constitutes a real public health problem, and that there is need to establish prevention programs at home and school to decrease or to control P. capitis with the support of public health authorities.

Authorizing an ongoing program of water resources research, and for other purposes. US House of Representatives, Ninety-Eighth Congress, First Session, Report No. 98-416

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

The favorable House report on HR 2911, which authorizes continued support of water resources research and conveys desalting test facilities to Wrightsville Beach, North Carolina and Roswell, New Mexico also recommends an amendment defining the function and operation of land-grant water resource institutes. The report traces the background of federal support in solving water problems. It summarizes, by section, the Water Resources Research Act's major points and estimates an authorization level of $60 million per year through 1988, with outlays starting at $15 million in 1984 and rising to $60 million by 1987. (DCK)

Knowing What You Eat: Researchers Are Looking for Ways to Help People Cope with Food Allergies.

PubMed

Grifantini, Kristina

2016-01-01

Food allergies and sensitivities have always been a public health problem but are becoming more prevalent worldwide. The U.S. Food and Drug Administration (FDA) reports that millions of Americans have allergic reactions to food each year. More than 17 million Europeans have a food allergy, and hospital admissions for severe reactions in children have risen sevenfold over the past decade, according to the European Academy of Allergy and Clinical Immunology.

Municipal solid waste management in Beijing City.

PubMed

Li, Zhen-shan; Yang, Lei; Qu, Xiao-Yan; Sui, Yu-mei

2009-09-01

This paper presents an overview of municipal solid waste (MSW) management in Beijing City. Beijing, the capital of China, has a land area of approximately 1368.32 km(2) with an urban population of about 13.33 million in 2006. Over the past three decades, MSW generation in Beijing City has increased tremendously from 1.04 million tons in 1978 to 4.134 million tons in 2006. The average generation rate of MSW in 2006 was 0.85 kg/capita/day. Food waste comprised 63.39%, followed by paper (11.07%), plastics (12.7%) and dust (5.78%). While all other wastes including tiles, textiles, glass, metals and wood accounted for less than 3%. Currently, 90% of MSW generated in Beijing is landfilled, 8% is incinerated and 2% is composted. Source separation collection, as a waste reduction method, has been carried out in a total of 2255 demonstration residential and commercial areas (covering about 4.7 million people) up to the end of 2007. Demonstration districts should be promoted over a wider range instead of demonstration communities. The capacity of transfer stations and treatment plants is an urgent problem as these sites are seriously overloaded. These problems should first be solved by constructing more sites and converting to new treatment technologies. Improvements in legislation, public education and the management of waste pickers are problematic issues which need to be addressed.

Municipal solid waste management in Beijing City

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li Zhenshan; Key Laboratory for Environmental and Urban Sciences, Shenzhen Graduate School, Peking University, Shenzhen 518055; Yang Lei

2009-09-15

This paper presents an overview of municipal solid waste (MSW) management in Beijing City. Beijing, the capital of China, has a land area of approximately 1368.32 km{sup 2} with an urban population of about 13.33 million in 2006. Over the past three decades, MSW generation in Beijing City has increased tremendously from 1.04 million tons in 1978 to 4.134 million tons in 2006. The average generation rate of MSW in 2006 was 0.85 kg/capita/day. Food waste comprised 63.39%, followed by paper (11.07%), plastics (12.7%) and dust (5.78%). While all other wastes including tiles, textiles, glass, metals and wood accounted formore » less than 3%. Currently, 90% of MSW generated in Beijing is landfilled, 8% is incinerated and 2% is composted. Source separation collection, as a waste reduction method, has been carried out in a total of 2255 demonstration residential and commercial areas (covering about 4.7 million people) up to the end of 2007. Demonstration districts should be promoted over a wider range instead of demonstration communities. The capacity of transfer stations and treatment plants is an urgent problem as these sites are seriously overloaded. These problems should first be solved by constructing more sites and converting to new treatment technologies. Improvements in legislation, public education and the management of waste pickers are problematic issues which need to be addressed.« less

An Assessment of Brazil’s Economic and Energy Problems

DTIC Science & Technology

1988-04-01

regions of Brazil have similar problems. The * huge Campo Cerrado region covering 500 million acres, or an area equal to 12 of the midwestern states...OF BRAZIL’S ECONOMIC AND ENERGY PROBLEMS by Keith D. Hawkins Lieutenant Colonel, USAF A RESEARCH REPORT SUBMITTED TO THE FACULTY IN FULFILLMENT OF... THE RESEARCH REQUIREMENT Research Advisor: Lieutenant Colonel George M. Lauderbuagh MAXWELL AIR FORCE BASE, ALABAMA April 1988 L. - -I ._ .! I I El II

Cost implications of ACGME's 2011 changes to resident duty hours and the training environment.

PubMed

Nuckols, Teryl K; Escarce, José J

2012-02-01

In July 2011, the Accreditation Council for Graduate Medical Education (ACGME) will implemented stricter duty-hour limits and related changes to the training environment. This may affect preventable adverse event (PAE) rates. To estimate direct costs under various implementation approaches, and examine net costs to teaching hospitals and cost-effectiveness to society across a range of hypothetical changes in PAEs. A decision-analytical model represented direct costs and PAE rates, mortality, and costs. Published literature and publicly available data. Patients admitted to hospitals with ACGME-accredited programs. One year. All teaching hospitals, major teaching hospitals, society. ACGME's 2011 Common Program Requirements. Direct annual costs (all accredited hospitals), net cost (major teaching hospitals), cost per death averted (society). RESULTS OF BASE-ANALYSIS: Nationwide, duty-hour changes would cost $177 million annually if interns maintain current productivity, vs. up to $982 million if they transfer work to a mixture of substitutes; training-environment changes will cost $204 million. If PAEs decline by 7.2-25.8%, net costs to major teaching hospitals will be zero. If PAEs fall by 3%, the cost to society per death averted would be -$523,000 (95%-confidence interval: -$1.82 million to $685,000) to $2.44 million ($271,000 to $6.91 million). If PAEs rise, the policy will be cost-increasing for teaching hospitals and society. The total direct annual cost nationwide would be up to $1.34 billion using nurse practitioners/physician assistants, $1.64 billion using attending physicians, $820 million hiring additional residents, vs. 1.42 billion using mixed substitutes. The effect on PAEs is unknown. Data were limited for some model parameters. Implementation decisions greatly affect the cost. Unless PAEs decline substantially, teaching hospitals will lose money. If PAEs decline modestly, the requirements might be cost-saving or cost-effective to society.

Estimating the economic value of British Columbia's domestic cannabis market: implications for provincial cannabis policy.

PubMed

Werb, Dan; Nosyk, Bohdan; Kerr, Thomas; Fischer, Benedikt; Montaner, Julio; Wood, Evan

2012-11-01

British Columbia (BC), Canada, is home to a large illegal cannabis industry that is known to contribute to substantial organized crime concerns. Although debates have emerged regarding the potential benefits of a legally regulated market to address a range of drug policy-related social problems, the value of the local (i.e., domestically consumed) cannabis market has not been characterized. Monte Carlo simulation methods were used to generate a median value and 95% credibility interval for retail expenditure estimates of the domestic cannabis market in BC. Model parameter estimates were obtained for the number of cannabis users, the frequency of cannabis use, the quantity of cannabis used, and the price of cannabis from government surveillance data and studies of BC cannabis users. The median annual estimated retail expenditure on cannabis by British Columbians was $407 million (95% Credibility Interval [CI]: $169-948 million). Daily users accounted for the bulk of the cannabis revenue, with a median estimated expenditure of approximately $357 million (95% CI: $149-845 million), followed by weekly users ($44 million, 95% CI: $18-90 million), and monthly users ($6 million, 95% CI: $3-12 million). When under-reporting of cannabis use was adjusted for, the estimated retail expenditure ranged from $443 million (95% CI: $185-1 billion) to $564 million (95% CI: $236-1.3 billion). Based on local consumption patterns, conservative estimates suggest that BC's domestic illegal cannabis trade is worth hundreds of millions of dollars annually. Given the value of this market and the failure and harms of law enforcement efforts to control the cannabis market, policymakers should consider regulatory alternatives. Copyright © 2012 Elsevier B.V. All rights reserved.

Microchip problems plague DOD

NASA Astrophysics Data System (ADS)

Smith, R. J.

1984-10-01

The major issues in the controversy over the discovery of millions of defective microchips sold to the DOD by the Texas Instruments (TI) corporation are outlined. Defects in the microcircuits are blamed on inadequate testing procedures performed by TI during manufacture, and on inadequate testing procedures used by a subcontractor especially contracted to test the chips. Because the problem persisted over a period of years, defects might be possible in as many as 100 million chips used in a broad range of military applications including the Trident submarine, the B-52, B-1B, F-15, F-111, F-4, A-6, and A-7 aircraft, the Harpoon and HARM missile systems, and the Space Shuttles Discovery and Challenger. It is pointed out that although TI has accepted responsibility for the defective chips, little will be done by the DOD to compel the company to replace them, or to upgrade testing procedures. It is concluded that the serious nature of the problem could renew interest in recommendations for the standardization of military microcircuits.

[Environmental and occupational problems in the utilization of industrial and home waste].

PubMed

Rusakov, N V; Rakhmanin, Iu A

2002-01-01

One of the acute hygienic problems of today is handling industrial and consumer wastes stored in Russia in the amount of 30 milliard tons; 30 million of solid garbage and 120 million tons of industrial wastes being formed. There are 4 garbage-handling and 10 garbage disposal plants built in the country. A third of them don't operate now. An absence of the initial selection in garbage collection causes the situation when only 3% of solid garbage is being processed. There is no state unified wastes recycling and utilizing system, no training of personnel to work out special technologies and do this work. Special attention should be given to medical wastes dangerous for the epidemiological situation, since they contain pathogenic microorganisms and helminth eggs; they may as well be contaminated by toxic and radioactive chemicals. A complex solution of the problems of industrial and consumer wastes handling is of vital importance for human health protection and protection of environment.

Some Statistical Characteristics of Special Education for Children with Disabilities in North-East India

ERIC Educational Resources Information Center

Kalita, Jumi; Sarmah, Pranita

2012-01-01

It is estimated that of approximately 150-250 million children with disabilities across the world, a large number have difficulties related to problems in the central nervous system (CNS). This paper considers school dropout rates of children with special educational needs associated with CNS problems from a study of educational institutions in…

World Food Day Curriculum, Grades K-3.

ERIC Educational Resources Information Center

Zander, Janet

Hunger and malnutrition lead to the deaths of 13-18 million people a year; 75 percent of these victims are children. World Food Day was created to focus attention on the world's food and farm problems and to encourage the world's people to become directly involved in the solution of these problems. It is sponsored jointly by the United Nations…

Problems of the Education and Inclusion of People with Disabilities

ERIC Educational Resources Information Center

Khudorenko, E. A.

2011-01-01

One of the most urgent problems today is the prevalence of disabilities and the loss of health. According to World Health Organization data, there are more than 600 million handicapped people in the world. Despite measures in effect for the normative legal regulation of the life and activity of people with disabilities in Russia, the present…

Eyes on the Workplace.

ERIC Educational Resources Information Center

Cowen, Ron

During the next 25 years, the number of Americans over age 65 is expected to reach 50 million. Although many will not experience age-related visual impairments until the age of 60 or 70, some will begin to experience serious problems by the age of 40. The types of vision problems experienced by individuals as they age include difficulty in…

Design, preparation and activity of intelligent cellulose-based protease sensor & modulating/fibroblast promoting (protos-fibro) dressings

USDA-ARS?s Scientific Manuscript database

Chronic wounds are a major clinical problem with an estimated 40 million people suffering from them worldwide, and one of the most costly healthcare problems today. ‘Intelligent’ dressings may be defined as materials that respond to specific changes in the wound environment i.e. exudate volume, and...

Child Labor, Learning Problems, and Poverty

ERIC Educational Resources Information Center

Taylor, Mark

2017-01-01

In Africa, approximately 80 million children are working. Africa's 41% child labor rate is nearly twice as high as that in Asia. This study examined whether child labor is a direct result of poverty or of reading and math problems in school. The study analyzed reading and math scores of 62 child laborers and 62 non-child laborers from a farming…

Street Youth: Adaptation and Survival in the AIDS Decade.

ERIC Educational Resources Information Center

Luna, G. Cajetan

Street youth remain at the fringes of society reflecting larger inherent social problems. Whether due to the death of parents, as a result of war, poverty, famine, disease, abandonment or abuse the health and social problems of the world's 100 million street youth are profound. By 1987 it was accepted that street youth were a high risk population…

Time's Up, Turkey--Pop-Up Thermometers

ERIC Educational Resources Information Center

Moyer, Richard; Everett, Susan

2009-01-01

Meat thermometers can be awkward to use in terms of placement and avoidance of bones. Because of these problems, each year 30 million Thanksgiving turkeys have a built-in thermometer that pops up when the turkey is properly cooked. Turkey timers are an example of how engineering solved a common, everyday problem. The following 5E learning cycle…

Speech Problems

MedlinePlus

... if you're in your teens and still stuttering, you may not feel like it's so endearing. ... million Americans have the speech disorder known as stuttering (or stammering, as it's known in Britain). It's ...

Israel: World Oil Report 1991

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1991-08-01

This paper reports that Major activity in 1990 was Israel National Oil Co.'s startup in November of a $30 million exploratory drilling program near the Dead Sea. Isramco's deep Yam 2 offshore wildcat was apparently suspended after gas shows and mechanical problems. In 1990, the Negev venture 2, led by Isramco, acquired an additional one million-acre offshore exploration license between Ashdod (offshore from which Yam 2 was sited) and Haifa. The group plans a $40-million three-well program. Drilling last year totaled four wells and 31,114 ft of hole. Included were one oil well extension and three dry holes. This year,more » eight onshore wildcats and two development wells, plus one offshore wildcat are expected to be drilled. Production averaged only 248 bopd and 3.2 MMcfgd in 1990. Reserves are estimated at 1.3 million bbl of oil and 6.8 bcfg.« less

What Works for Asthma Education Programs: Lessons from Experimental Evaluations of Social Programs and Interventions for Children. Fact Sheet. Publication #2012-01

ERIC Educational Resources Information Center

Chrisler, Alison

2012-01-01

Asthma is a chronic respiratory disease that affects millions of children and adolescents each year. In 2009, 7.1 million children ages 0 to 17 years were reported to have asthma. Unfortunately, when children and teens are unable to manage and cope with their disease, it can compromise their physical, academic, and social development. Therefore,…

Personality and Social Influence Characteristic Affects on Ease of Use and Peer Influence of New Media Users Over Time

DTIC Science & Technology

2011-03-01

online social networking sites (SNSs) have emerged in today’s society as seen in the SNS Facebook and its over 500 million users. Millions of people...and locations through the social networking site ( SNS ) Facebook (Ghonim, 2011). Through the Facebook page created by Ghonim “We are all Khalid...1 Social Network Sites Defined ......................................................................................3 Purpose and

Globalization and the trends of medical technology trade in Turkey.

PubMed

Semin, Semih; Güldal, Dilek; Demiral, Yücel

2007-05-01

Medical technology trade is one of the most affected health areas by global regulations in the developing countries. The aim of the study is to examine recent changes in medical technology import and export and their results in Turkey. Data show that the total medical technology imports (MTI) increased from $ 34.6 million to $ 3427.9 million between 1970 and 2003. While MTI constituted 3.6% of total imports in 1970 and 1.3% in 1980, this ratio raised up to 4.9% in 2003. The ratio of MTI in total health expenditures were also increased from 7.6% in 1970 to 31.5% in 2003. Medical technology exports (MTE) have been increased from $ 0.9 million in 1970 to $ 303.2 million in 2003. The ratio of MTE to MTI increased from 2.7% to 13.9% between 1970 and 1990 and decreased after 1990, to 8.8%. Our study implied that the medical technology trade in Turkey has been negatively affected and in some respects differs from some other important industries in the globalization era. Nevertheless, detailed comparative studies in different developing countries such as China, Brazil, Mexico and India, are needed to explore the real state of medical technology trade, use and the effects of globalization on these topics.

RETINAL VEIN OCCLUSIONS, FROM BASICS TO THE LATEST TREATMENT.

PubMed

Ho, Mary; Liu, David T L; Lam, Dennis S C; Jonas, Jost B

2016-03-01

To review the pathophysiology, diagnosis, and updated treatments of retinal vein occlusions (RVOs). A review of the literature was performed, focusing on the epidemiology, pathophysiology, diagnosis, and treatments (including both medical and surgical treatments) of RVO. Based on this review, a comprehensive overview was provided regarding the topic of RVO and focused on recent treatment updates. Retinal vein occlusions have an age- and sex-standardized prevalence of 5.20 per 1,000 for any RVO, 4.42 per 1,000 for branch RVO, 0.80 per 1,000 for central RVO. Worldwide, an estimated 16.4 million adults are affected by RVOs, with 2.5 million affected by central RVO and 13.9 million affected by branch RVO. Retinal vein occlusion is recognized as an important cause of blindness and the diagnostic approaches and treatment options for RVO are reviewed and reported. The current treatment options including medical treatments (bevacizumab, ranibizumab, aflibercept, triamcinolone, and dexamethasone implants) and surgical alternatives were reviewed and reported with summaries on the corresponding strength of evidence. Despite the understanding of this disease entity, challenges persist in the long-term treatment of RVO-related complications and visual loss. This review provided a detailed summary on the rationality and efficacy of recently developed treatment regimes and evaluated the potential benefit of combination therapy.

Lung Diseases

MedlinePlus

... 000 times. People with lung disease have difficulty breathing. Millions of people in the U.S. have lung ... pneumonia and tuberculosis, lung cancer, and many other breathing problems. Some lung diseases can lead to respiratory ...

National and subnational prevalence and burden of glaucoma in China: A systematic analysis.

PubMed

Song, Peige; Wang, Jiawen; Bucan, Kajo; Theodoratou, Evropi; Rudan, Igor; Chan, Kit Yee

2017-12-01

Glaucoma, the second leading cause of blindness, affects approximately 64.3 million individuals worldwide. In China, demographic ageing is in rapid progress. Yet detailed and up-to-date estimates of the scale of glaucoma are rare. We aimed to quantify and understand the prevalence and burden of glaucoma in China from 1990 to 2015, with projections until 2050. For this systematic review and meta-analysis, we searched China National Knowledge Infrastructure (CNKI), Wanfang, Chinese Biomedicine Literature Database (CBM-SinoMed), PubMed, Embase and Medline using comprehensive search strategies to identify all relevant articles that have reported the prevalence of glaucoma in the general Chinese population. We used a multilevel mixed-effect meta-regression to estimate the prevalence rates of primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG), and a random-effects meta-analysis to pool the overall prevalence of secondary glaucoma. United Nations population data were used to estimate and project the number of people with glaucoma from 1990 to 2050. Univariable and multivariable meta-regressions were conducted to assess the association between the prevalence of POAG and PACG and relevant demographic and geographic factors. The national burden of POAG and PACG in the years 2000 and 2010 were distributed to six geographic regions accordingly. From 1990 to 2015, the prevalence of all glaucoma ranged from 2.59% (95% CI = 1.96-3.49) to 2.58% (95% CI = 1.94-3.47). For different subtypes of glaucoma, the overall prevalence of POAG ranged from 1.03% (95% CI = 0.67-1.58) in 1990 to 1.02% (95% CI = 0.67-1.57) in 2015, PACG from 1.41% (95% CI = 1.18-1.68) to 1.40% (95% CI = 1.17-1.68). The overall prevalence of secondary glaucoma was 0.15% (95% CI = 0.10-0.23) during this period. The number of people with all glaucoma in China was 5.92 million (95% CI = 4.47-7.97) in 1990, and 13.12 million (95% CI = 9.88-17.68) in 2015. This increasing trend was also witnessed in different subtypes of glaucoma. The number of people affected by POAG increased from 2.35 million (95% CI = 1.54-3.60) in 1990 to 5.22 million (95% CI = 3.40-7.98) in 2015, PACG from 3.22 million (95% CI = 2.70-3.84) to 7.14 million (95% CI = 5.97-8.53), and secondary glaucoma from 0.34 million (95% CI = 0.23-0.53) to 0.76 million (95% CI = 0.51-1.17). In 2015, more than half (54.42%) of the glaucoma cases were PACG, followed by POAG (39.79%) and secondary glaucoma (5.79%). By 2050, the number of all glaucoma cases in China will be 25.16 million (95% CI = 18.96-33.86). In the multivariable meta-regressions, the odds ratio (OR) for each decade's increase in age was 1.43 (95% CI = 1.33-1.55) for POAG, and 1.65 (95% CI = 1.51-1.80) for PACG; males were more likely to have POAG (OR 1.36, 95% CI = 1.17-1.59), but less likely to have PACG (OR 0.53, 95% CI = 0.46-0.60) compared with females. After adjustment of age and gender, people living in urban areas were more likely to have POAG compared with those in rural areas (OR 1.54, 95% CI = 1.02-2.35). People in Northeast China were at a higher risk (OR 1.77, 95% CI = 1.07-2.94) of having PACG than people in East China. Among the six regions, East China owed the most POAG and PACG cases, whereas Northwest China owed the least. This systematic review and meta-analysis suggests a substantial burden of glaucoma in China, with great variances among the different age groups, genders, settings and geographic regions. With the dramatic ageing trend in the next three decades, the prevalence and burden of glaucoma will continue to increase. More elaborate epidemiological studies are needed to optimise public health strategies for mitigating this important health problem.

[The truth and present uncertainty about mad cow disease].

PubMed

Suárez Fernández, G

2001-01-01

A historical review is made about Spongiform Encephalopathies which affect both animals and man. This is the base for an epidemiological and predictive analysis of these type of diseases, especially Bovine Spongiform Encephalopathy (BSE) as a present health problem. The scientific certainties or truths, such as the prion theory (PrPc-PrPsc), the low natural infectivity of these group of diseases, the high dose of prions necessary to produce the experimental disease, the species barrier or specificity, the individual susceptibility due to genetic traits, and the low transmission efficiency by the oral route, compared to the parenteral route, agree with the epidemiological observations of human cases of the variant of the Creutzfeldt-Jakob disease (vCJD), which is 0.1 cases per million inhabitants and year. The present and future prediction of BSE should not be alarmist, taking into account the certainties that we know.

In vitro interaction between SURFACEN® and surfactant protein A against Leishmania amazonensis.

PubMed

de Guevara, Yuliannis Lugones Ladrón; Hidalgo, Odalys Blanco; Faure, Roberto; Fidalgo, Lianet Monzote

2013-01-01

Leishmaniasis is caused by a parasite of the Leishmania genus, affecting more than 12 million people in 98 countries. The control of leishmaniasis remains a serious problem. There are currently no vaccines for leishmaniasis. The drugs available are toxic, expensive and frequently ineffective. The in vitro activity of SURFACEN® and SP-A against Leishmania amazonensis was evaluated. The combination of both products resulted in a synergic pharmacology effect, demonstrated by a fractional inhibitory concentration index <0.5. A more effective combination was a SURFACEN/SP-A ratio of 4:1, using a method of fixed ratio. The therapeutic effect of SURFACEN and SP-A as antileishmanial compounds was demonstrated, with a potentiation of activity when they were incubated in conjunction. Our results propose an exploration of these products in order to design new formulations against the Leishmania parasite. © 2014 S. Karger AG, Basel.

Sexual and reproductive health is our business.

PubMed

Sarjeant, H

1993-01-01

The Family Planning Association of Trinidad and Tobago (FPATT) has decided that integration of the concept of sexual and reproductive health into regular family planning activities is the best way to increase the contraceptive prevalence rate. A more holistic approach to service provision is being developed. On the basis of survey findings that early sexual activity, low contraceptive use, and limited knowledge are widespread among young people, this population group has been selected as a focus. FPATT has asked for a TT$1 million subsidy to intensify sex education programs in the schools. Issues discussed include human sexuality, values clarification, relationships, problems affecting teenagers, parenting, rape and incest, and family planning. FPATT also conducts training sessions for teachers and parents. Since young people tend to respond best to peers, peer counseling is emphasized. Education is also offered at large industrial sites, private homes in small communities, and government health centers.

Promoting Food Security for All Children.

PubMed

2015-11-01

Sixteen million US children (21%) live in households without consistent access to adequate food. After multiple risk factors are considered, children who live in households that are food insecure, even at the lowest levels, are likely to be sick more often, recover from illness more slowly, and be hospitalized more frequently. Lack of adequate healthy food can impair a child's ability to concentrate and perform well in school and is linked to higher levels of behavioral and emotional problems from preschool through adolescence. Food insecurity can affect children in any community, not only traditionally underserved ones. Pediatricians can play a central role in screening and identifying children at risk for food insecurity and in connecting families with needed community resources. Pediatricians should also advocate for federal and local policies that support access to adequate healthy food for an active and healthy life for all children and their families. Copyright © 2015 by the American Academy of Pediatrics.

An ethical framework for the management of pain in the emergency department.

PubMed

Venkat, Arvind; Fromm, Christian; Isaacs, Eric; Ibarra, Jordan

2013-07-01

Pain is a ubiquitous problem, affecting more than 100 million individuals in the United States chronically and many more in the acute setting. Up to three-quarters of patients presenting to the emergency department (ED) report pain as a key component of their reasons for requiring acute care. While pain management is a fundamental component of emergency medicine (EM), there are numerous attitudinal and structural barriers that have been identified to effectively providing pain control in the ED. Coupled with public demands and administrative mandates, concerns surrounding ED pain management have reached a crisis level that should be considered an ethical issue in the profession of EM. In this article, the authors propose an ethical framework based on a combination of virtue, narrative, and relationship theories that can be used to address the clinical dilemmas that arise in managing pain in ED patients. © 2013 by the Society for Academic Emergency Medicine.

Specificity, cross-talk and adaptation in Interferon signaling

NASA Astrophysics Data System (ADS)

Zilman, Anton

Innate immune system is the first line of defense of higher organisms against pathogens. It coordinates the behavior of millions of cells of multiple types, achieved through numerous signaling molecules. This talk focuses on the signaling specificity of a major class of signaling molecules - Type I Interferons - which are also used therapeutically in the treatment of a number of diseases, such as Hepatitis C, multiple sclerosis and some cancers. Puzzlingly, different Interferons act through the same cell surface receptor but have different effects on the target cells. They also exhibit a strange pattern of temporal cross-talk resulting in a serious clinical problem - loss of response to Interferon therapy. We combined mathematical modeling with quantitative experiments to develop a quantitative model of specificity and adaptation in the Interferon signaling pathway. The model resolves several outstanding experimental puzzles and directly affects the clinical use of Type I Interferons in treatment of viral hepatitis and other diseases.

Computation models simulating notochordal cell extinction during early ageing of an intervertebral disc.

PubMed

Louman-Gardiner, K M; Coombe, D; Hunter, C J

2011-12-01

Lower back pain due to intervertebral disc (IVD) degeneration is a prevalent problem which drastically affects the quality of life of millions of sufferers. Healthy IVDs begin with high populations of notochordal cells in the nucleus pulposus, while by the second stage of degeneration, these cells will be replaced by chondrocyte-like cells. Because the IVD is avascular, these cells rely on passive diffusion of nutrients to survive. It is thought that this transition in cell phenotype causes the shift of the IVD's physical properties, which impede the flow of nutrients. Our computational model of the IVD illustrates its ability to simulate the evolving chemical and mechanical environments occurring during the early ageing process. We demonstrate that, due to the insufficient nutrient supply and accompanying changes in physical properties of the IVD, there was a resultant exponential decay in the number of notochordal cells over time.

In too deep: understanding, detecting and managing DVT.

PubMed

Meetoo, Danny

Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), is a serious health and social care problem of the developed world, affecting 1 in 1000 adults every year, and with an annual financial overhead of approximately £640 million. The nature of DVT means that often the condition can go unrecognized until the thrombus becomes an embolus. The pathogenesis of DVT continues to be based on Virchow's triad, which attributes VTE to 'hypercoagulability', 'stasis' and 'intimal injury'. The diagnosis of DVT is often the result of a number of tests performed either sequentially or in combination before mechanical and/or chemical treatment is embarked on. Creating public awareness of DVT and PE is the best way to prevent this condition. Nurses are in an ideal position to discuss the importance of lifestyle changes and other related measures to prevent DVT.

Mycobacterial glycolipids di-O-acylated trehalose and tri-O-acylated trehalose downregulate inducible nitric oxide synthase and nitric oxide production in macrophages.

PubMed

Espinosa-Cueto, Patricia; Escalera-Zamudio, Marina; Magallanes-Puebla, Alejandro; López-Marín, Luz María; Segura-Salinas, Erika; Mancilla, Raúl

2015-06-23

Tuberculosis (TB) remains a serious human health problem that affects millions of people in the world. Understanding the biology of Mycobacterium tuberculosis (Mtb) is essential for tackling this devastating disease. Mtb possesses a very complex cell envelope containing a variety of lipid components that participate in the establishment of the infection. We have previously demonstrated that di-O-acylated trehalose (DAT), a non-covalently linked cell wall glycolipid, inhibits the proliferation of T lymphocytes and the production of cytokines. In this work we show that DAT and the closely related tri-O-acylated trehalose (TAT) inhibits nitric oxide (NO) production and the inducible nitric oxide synthase (iNOS) expression in macrophages (MØ). These findings show that DAT and TAT are cell-wall located virulence factors that downregulate an important effector of the immune response against mycobacteria.

Alcohol outlet business hours and violent crime in New York state.

PubMed

Schofield, Timothy P; Denson, Thomas F

2013-01-01

Alcohol-related harm places a significant strain on victims, perpetrators and society. The present research reports on how licensed alcohol outlet business hours may influence the reported incidence of interpersonal violence and the associated burden of disease. We examined the relationship between alcohol outlet business hours and violent crime in 2009 in New York State (excluding New York City). Regression analyses modeled the burden of disease for the violence associated with outlet business hours. Every 1 h increase in weekly outlet business hours was associated with a greater reported incidence of violent crimes generally, more reported aggravated assaults and more reported non-gun violence. The estimated cost from having licensed premises open after 1 a.m. was $194 million in 2009. The findings suggest that alcohol outlet business hours affect the incidence of reported violence even in regions that would not be considered to have severe problems with alcohol-fueled violence.

Human health implications, risk assessment and remediation of As-contaminated water: A critical review.

PubMed

Shakoor, Muhammad Bilal; Nawaz, Rab; Hussain, Fida; Raza, Maimoona; Ali, Shafaqat; Rizwan, Muhammad; Oh, Sang-Eun; Ahmad, Sajjad

2017-12-01

Arsenic (As) is a naturally occurring metalloid and Class-A human carcinogen. Exposure to As via direct intake of As-contaminated water or ingestion of As-contaminated edible crops is considered a life threatening problem around the globe. Arsenic-laced drinking water has affected the lives of over 200 million people in 105 countries worldwide. Limited data are available on various health risk assessment models/frameworks used to predict carcinogenic and non-carcinogenic health effects caused by As-contaminated water. Therefore, this discussion highlights the need for future research focusing on human health risk assessment of individual As species (both organic and inorganic) present in As-contaminated water. Various conventional and latest technologies for remediation of As-contaminated water are also reviewed along with a discussion of the fate of As-loaded waste and sludge. Copyright © 2017 Elsevier B.V. All rights reserved.

Employee assistance program services for alcohol and other drug problems: implications for increased identification and engagement in treatment.

PubMed

Jacobson, Jodi M; Sacco, Paul

2012-01-01

Fourteen million U.S. workers meet the diagnostic criteria for substance dependence, costing millions in lost productivity. Prior research suggests that employees who follow through with their Employee Assistance Program's (EAP) recommendations are more likely to participate and remain engaged in alcohol and other drug (AOD) treatment programs. This study identified rates of lifetime EAP service use for AOD problems and compared adults who reported using EAP services for AOD problems with those who used services other than EAP. Researchers analyzed a subset of participants from the National Epidemiologic Survey of Alcohol and Related Conditions who reported having received help for an AOD problem (NESARC, 2001-2002). Statistical analyses tested for differences in sociodemographic variables, lifetime mental health and substance abuse disorders, and health disability between EAP services users and users of other types of services. Among adults who sought services for AOD problems (n= 2,272), 7.58% (n= 166) reported using EAP services for these problems at some point during their lives. Major depressive disorder (lifetime), a drug use disorder (lifetime), and Black race/ethnicity were associated with a greater likelihood that someone would seek EAP services for help with their AOD problem. Results provide a foundation for researchers to understand who uses EAP services for AOD problems. Health and mental health professionals should increase their knowledge of EAP services to improve continuity of care for employees with AOD problems. EAPs are in a unique position to reach out to vulnerable employees in the workplace and engage them in treatment. Copyright © American Academy of Addiction Psychiatry.

Navy Budget: Potential Reductions for Research, Development, Test, and Evaluation

DTIC Science & Technology

1990-11-01

available for use in future Navy programs, including the MK-50 tor- pedo and Vertical Launch Antisubmarine Rocket. A total of $49.9 million of fiscal...346 Travel 03 07 + 04 Support 224 225 + 01 Total Requested $122.61 $122.61 -0- In addition, the Navy plans to acquire six Acoustic Video Processor...units at $2.4 million in fiscal year 1991. The Acoustic Video Processor pro- gram is experiencing development problems, and the full-scale develop- ment

Do British travel agents provide adequate health advice for travellers?

PubMed Central

Lawlor, D A; Burke, J; Bouskill, E; Conn, G; Edwards, P; Gillespie, D

2000-01-01

Travel-related illness is a burden for primary care, with more than two million travellers consulting a general practitioner each year. The annual cost of travel-related illness in the United Kingdom is 11 million Pounds. Travel agents are in a unique position to influence this burden as the most common and most serious problems are preventable with simple advice and/or immunisation. This study, using covert researchers, suggests this potential is not being fully utilised. PMID:10954940

The Evolution of Wildland Fire Management Policy in the USA: Successes and Failures

NASA Astrophysics Data System (ADS)

Gonzalez-Caban, A.

2015-12-01

Wildfires have been suppressed over the last 100 years in forest and brush landscapes. For the last three decades, fires occurrence and severity have significantly increased when compared to historical levels causing economic damage and suppression costs never experienced before in the US or globally. As the wildland fire problem evolved so did the public response through a wildland fire management policy guided by the Forest Service and Bureau of Land Management understanding of the problem. Globally it is estimated that more 350 million hectares of wildland burn annually. They oxidize approximately 3-8% of the total terrestrial net primary productivity. The economic and physical relevance of wildland fire management and protection programs is ever growing, particularly considering mounting wildfire costs and losses globally. In the US alone, from 2000 to 2013 more than 37 million hectares of wildland has been affected at a cost of over $21 billion. The increase in siege-like fires can be explained in part by increasing population, particularly in the wildland-urban interface and the accumulation of biomass fuel due to over a century of fire exclusion. Recent developments demonstrate a strong relationship between fire and weather and climate variations. How the wildland fire management policy has evolved through time? The development can be divided in three stages: the formative years between 1905 and 1911; the consolidation years from 1911 through 1968; and the modern era from 1995 to present. Each stage is characterized by a series of significant events that caused changes on how the problem was approached. For example, the establishment of the Forest Service in 1905 and the rash of large wildfires in the western USA set the base for the wildfire suppression of all wildfires in 1911. During the second stage we see the 1935 policy of suppressing all wildfires by 10-am next-day. By 1968 the policy has evolved to include the use of prescribed burning and the elimination of the 10-am next-day policy. In the modern era, by 1995 the wildland fire management policy changed to require the use of economic efficiency analysis in fire suppression actions. The recently passed FLAME Act and establishment of the FS Cohesive Strategy have been in response to increases in the wildland-urban interface problem and climate change challenges.

[Diarrhea from the infectologist's point of view].

PubMed

Nemes, Zsuzsanna

2009-02-22

Gastroenteritis is a nonspecific term for various pathologic states of the gastrointestinal tract. Gastroenteritis causing pathogens are the second leading cause of morbidity and mortality worldwide. In the developed countries diarrhea is the most common reason for missing work, while in the developing world, it is a leading cause of death. Internationally, the mortality rate is 5-10 million deaths each year. "Traveller's diarrhea" is a polyetiologic common health problem of international travellers which affects travellers generally for days, but it can result in chronic postinfectious irritable bowel syndrome as well. Infectious agents usually cause acute gastroenteritis either by adherence of the intestinal mucosa, or by mucosal invasion, enterotoxin production, and/or cytotoxin production. The incubation period can often suggest the cause of etiology. When symptoms occur within 6 hours of eating, ingestion of preformed toxin of S. aureus or Bacillus cereus should be suspected. The incidence of hypervirulent C. difficile associated colitis is an emerging problem as a healthcare system associated infection. While infectious agents do not commonly cause chronic diarrhea, those that do include C. difficile, Giardia lamblia, Entamoeba histolytica, Cryptosporidium, Aeromonas and Yersinia . Amoebiasis is the second to malaria as a protozoal cause of death. Infection with HIV is also a common cause of diarrhea.

Immediate metabolic consequences of intrauterine growth restriction and low birthweight.

PubMed

Bhatia, Jatinder; Gates, Amy

2013-01-01

Optimal fetal growth resulting in a 'normally grown' term infant is of paramount importance for assuring a healthy start for postnatal growth and development. Fetal, infant and childhood growth restriction is an important clinical problem for obstetricians, neonatologists, pediatricians and globally, for public health. Worldwide, an estimated 20 million infants are born with low birthweight and a substantial proportion are small for gestational age. Many advances have been made in defining growth restriction by prenatal techniques, thus allowing the recognition of intrauterine growth restriction. Distinguishing infants who are small but have appropriate growth potential from those with growth restriction is important in order to apply obstetric surveillance, anticipate neonatal problems and plan for postneonatal guidance. It is clear that the fetus in growth-restricted pregnancies has limited supply of nutrients and oxygen. The resultant changes, if involving the placenta as well, can lead to circulatory and metabolic changes affecting both short- and long-term survival and development. In this paper, the causes and immediate consequence of being born with low birthweight, intrauterine growth restriction or small for gestational age will be discussed. Copyright © 2013 Nestec Ltd., Vevey/S. Karger AG, Basel.

Public health impact of androgens.

PubMed

Kanayama, Gen; Kaufman, Marc J; Pope, Harrison G

2018-06-01

To summarize recent findings regarding the public health impact of androgen abuse. Abuse of androgens (also called 'anabolic-androgenic steroids') has grown into a major worldwide substance abuse problem involving tens of millions of individuals, of whom about 98% are men. Most androgen abusers are still under age 50 today, and thus, the long-term effects of these drugs are only beginning to be understood. Recent studies confirm that long-term supraphysiologic androgen exposure produces cardiovascular toxicity, characterized especially by cardiomyopathy and atherosclerotic disease. Withdrawal from androgens after long-term use may produce prolonged and sometimes irreversible hypogonadism in men. Supraphysiologic androgen levels may sometimes cause irritability, aggressiveness, and violence, whereas androgen withdrawal may cause depression. However, these psychiatric effects are idiosyncratic, affecting only a minority of users. Emerging evidence now also suggests that long-term androgen exposure may cause neurotoxicity, raising the possibility that aging androgen abusers may be at increased risk for dementia. Several recent studies have also described androgen-induced hepatotoxicity, nephrotoxicity, and adverse musculoskeletal effects. Recent studies have demonstrated marked adverse effects of long-term androgen abuse. As increasing numbers of androgen abusers reach middle age, these effects will likely represent an emerging public health problem.

The Effectiveness of Mindfulness-Based Cognitive Group Therapy on Marital Satisfaction and General Health in Woman With Infertility.

PubMed

Abedi Shargh, Najmeh; Bakhshani, Nour Mohammad; Mohebbi, Mohammad Davoud; Mahmudian, Khadije; Ahovan, Masood; Mokhtari, Mojgan; Gangali, Alireza

2015-08-06

Infertility affects around 80 million people around the world and it has been estimated that psychological problems in infertile couples is within the range of 25-60%. The purpose of this study was to determine the effectiveness of Mindfulness-based cognitive group therapy on consciousness regarding marital satisfaction and general health in woman with infertility. Recent work is a clinical trial with a pre/posttest plan for control group. Covering 60 women who were selected by in access method and arranged randomly in interference (30) and control (30) groups. Before and after implementation of independent variable, all subjects were measured in both groups using Enrich questionnaire and marital satisfaction questionnaire. Results of covariance analysis of posttest, after controlling the scores of pretest illustrated the meaningful difference of marital satisfaction and mental health scores in interference and control groups after treatment and the fact that MBCT treatment in infertile women revealed that this method has an appropriate contribution to improvement of marital satisfaction and mental health. Necessary trainings for infertile people through consultation services can improve their mental health and marital satisfaction and significantly help reducing infertile couples' problems.

[Bridging the divide: global lessons from evidence-based health policy in Mexico].

PubMed

Frenk, Julio

2007-01-01

During the past six years, Mexico has undergone a large-scale transformation of its health system. This paper provides an overview of the main features of the Mexican reform experience. Because of its high degree of social inequality, Mexico is a microcosm of the range of problems that affect countries at all levels of development. Its health system had not kept up with the pressures of the double burden of disease, whereby malnutrition, common infections, and reproductive health problems coexist with non-communicable disease and injury. With half of its population uninsured, Mexico was facing an unacceptable paradox: whereas health is a key factor in the fight against poverty, a large number of families became impoverished by expenditures in health care and drugs. The reform was designed to correct this paradox by introducing a new scheme called Popular Health Insurance (Seguro Popular). This innovative initiative is gradually protecting the 50 million Mexicans, most of them poor, who had until now been excluded from formal social insurance. This paper reports encouraging results in the achievement of the ultimate objective of the reform: universal access to high-quality services with social protection for all.

Bridging the divide: global lessons from evidence-based health policy in Mexico.

PubMed

Frenk, Julio

2006-09-09

During the past 6 years, Mexico has undergone a large-scale transformation of its health system. This paper provides an overview of the main features of the Mexican reform experience. Because of its high degree of social inequality, Mexico is a microcosm of the range of problems that affect countries at all levels of development. Its health system had not kept up with the pressures of the double burden of disease, whereby malnutrition, common infections, and reproductive health problems coexist with non-communicable disease and injury. With half of its population uninsured, Mexico was facing an unacceptable paradox: whereas health is a key factor in the fight against poverty, a large number of families became impoverished by expenditures in health care and drugs. The reform was designed to correct this paradox by introducing a new scheme called Popular Health Insurance (Seguro Popular). This innovative initiative is gradually protecting the 50 million Mexicans, most of them poor, who had until now been excluded from formal social insurance. This paper reports encouraging results in the achievement of the ultimate objective of the reform: universal access to high-quality services with social protection for all.

Giardiasis outbreaks in the United States, 1971–2011

PubMed Central

Adam, E. A.; Yoder, J. S.; Gould, L. H.; Hlavsa, M. C.; Gargano, J. W.

2016-01-01

Summary Giardia intestinalis is the leading parasitic aetiology of human enteric infections in the United States, with an estimated 1.2 million cases occurring annually. To better understand transmission, we analysed data on all giardiasis outbreaks reported to the Centers for Disease Control and Prevention for 1971–2011. The 242 outbreaks, affecting ∼41 000 persons, resulted from waterborne (74.8%), foodborne (15.7%), person-to-person (2.5%), and animal contact (1.2%) transmission. Most (74.6%) waterborne outbreaks were associated with drinking water, followed by recreational water (18.2%). Problems with water treatment, untreated groundwater, and distribution systems were identified most often during drinking water-associated outbreak investigations; problems with water treatment declined after the 1980s. Most recreational water-associated outbreaks were linked to treated swimming venues, with pools and wading pools implicated most often. Produce was implicated most often in foodborne outbreaks. Additionally, foods were most commonly prepared in a restaurant and contaminated by a food handler. Lessons learned from examining patterns in outbreaks over time can help prevent future disease. Groundwater and distribution system vulnerabilities, inadequate pool disinfection, fruit and vegetable contamination, and poor food handler hygiene are promising targets for giardiasis prevention measures. PMID:26750152

Municipal-level responses to household food insecurity in Canada: a call for critical, evaluative research.

PubMed

Collins, Patricia A; Power, Elaine M; Little, Margaret H

2014-04-09

Household food insecurity (HFI) is a persistent public health problem affecting 3.8 million Canadians. While the causes of HFI are rooted in income insecurity, solutions to HFI have been primarily food-based, with the bulk of activity occurring at the municipal level across Canada. We conceptualize these municipal-level actions as falling within three models: "charitable", "household improvements and supports" and "community food systems". Many initiatives, especially non-charitable ones, generate widespread support, as they aim to increase participants' food security using an empowering and dignified approach. While these initiatives may offer some benefits to their participants, preliminary research suggests that any food-based solution to an income-based problem will have limited reach to food-insecure households and limited impact on participants' experience of HFI. We suspect that widespread support for the local-level food-based approach to HFI has impeded critical judgement of the true potential of these activities to reduce HFI. As these initiatives grow in number across Canada, we are in urgent need of comprehensive and comparative research to evaluate their impact on HFI and to ensure that municipal-level action on HFI is evidence-based.

Allergic rhinitis-induced nasal congestion: its impact on sleep quality.

PubMed

Storms, William

2008-03-01

Allergic rhinitis (AR) is an extremely common health problem affecting 20 to 40 million Americans and between 10-25% of the world's population. Patients with AR suffer from both nasal symptoms (congestion, rhinorrhea, itching, and sneezing) and ocular symptoms (itching, redness, and tearing). The negative impact on sleep quality and quantity, and consequently on various aspects of the patient's life, is an under-recognised and under-treated component of AR morbidity. Nasal congestion, which is one of the most bothersome and prevalent symptoms of AR, is thought to be the leading symptom responsible for rhinitis-related sleep problems. In addition to reducing clinical symptoms, pharmacologic therapies for AR that specifically reduce inflammatory cells and mediators - and therefore nasal congestion and other symptoms - should also improve sleep quality and overall quality of life (QOL). Intranasal corticosteroids (INS) are the current mainstay of therapy for AR. Results of a number of clinical trials demonstrate that INS effectively reduce nasal congestion and ocular symptoms, improve sleep quality, and decrease daytime somnolence. Intranasal corticosteroids have also proved to be effective in reducing symptoms of acute rhinosinusitis and nasal polyposis, both of which also negatively impact on sleep quality. Intranasal corticosteroids are considered safe due to their low systemic bioavailability.

Fragranced consumer products: effects on asthmatic Australians.

PubMed

Steinemann, Anne; Wheeler, Amanda J; Larcombe, Alexander

2018-01-01

Exposure to fragranced consumer products, such as air fresheners and cleaning supplies, is associated with adverse health effects such as asthma attacks, breathing difficulties, and migraine headaches. This study investigated the prevalence and types of health problems associated with exposure to fragranced products among asthmatic Australians. Nationally representative cross-sectional data were obtained in June 2016 with an online survey of adult Australians ( n  = 1098), of which 28.5% were medically diagnosed with asthma or an asthma-like condition. Nationally, 55.6% of asthmatics, and 23.9% of non-asthmatics, report adverse health effects after exposure to fragranced products. Specifically, 24.0% of asthmatics report an asthma attack. Moreover, 18.2% of asthmatics lost workdays or a job in the past year due to fragranced products in the workplace. Over 20% of asthmatics are unable to access public places and restrooms that use air fresheners. Exposure to fragranced products is associated with health problems, some potentially serious, in an estimated 2.2 million asthmatic adult Australians. Asthmatics were proportionately more affected than non-asthmatics (prevalence odds ratio 3.98; 95% confidence interval 3.01-5.24). Most asthmatics would prefer workplaces, healthcare facilities, and environments that are fragrance-free, which could help reduce adverse effects.

Leadership Education and Service: Exploring Transformational Learning Following a Tornado

ERIC Educational Resources Information Center

Buschlen, Eric; Warner, Cathleen; Goffnett, Sean

2015-01-01

Each year, millions of people around the world are affected by natural disasters. Following these disasters, many students from colleges and universities arrive to support the affected areas. These seamless leadership learning opportunities engage students by allowing them to implement the concepts they learned in a classroom. Humanitarian relief…

E. coli in PA streams as affected by climate forcing

USDA-ARS?s Scientific Manuscript database

Each year, more than 9 million foodborne illnesses are estimated to be caused by major pathogens. More than 70% of the cropland for vegetables is irrigation water may contain pathogens or potential bacteria that affect human health. The FDA (Food and Drug Administration) has issued regulations manda...

A local experience is often a global experience, forum attendees hear

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-06-01

This paper reports that in the first session on supply/demand Roman Samsonov of NPO Soyuzgastechnologiya gave delegates an insight into developing the Soviet gas industry, providing a look at the structure of the industry and consumption patterns. Residential and petrochemical customers are the basic consumers. As of last Jan. 1, 34.6 million apartments used LPG, with at least 150 million people using the fuel for cooling alone. Consumption has greatly increased since the 1970s. In 1970, 4.9 million tonnes of LPG were consumed and by 1980, 8.81 million tonnes. However, the production of LPG in 1990 had reached only 10.5more » million tonnes, about 70% of its domestic needs. Samsonov noted that complete satisfaction of the domestic market can be reached only at the expense of solving the problem of transportation and investing in repairing and keeping facilities going at the Gorky oil refining plant and the Gnedintsovo and Minnibayev oil refining plants. These actions would allow LPG production to increase by more than 10% from the present day production.« less

The tobacco problem in Denmark and the difficulties in implementing an organized plan of action.

PubMed

Egsmose, T

1985-08-01

In Denmark tobacco consumption has increased considerably during the last few decades. Almost 2 million people of a population of 5 million are smokers. Of the male population 48% are smokers, of the female population 46%. From 1981 to 1982 the cigarette consumption increased from 7,300 million to 8,000 million. Consumption of pipe tobacco increased slightly, whereas cigars and cigarillos were considerably reduced. The tobacco tax amounts to 6,500 million Dan. kr. annually (700 million US$). The tobacco industry's cost of marketing tobacco products are unknown, but advertising, for one thing, amounts to 25 million Dan.kr. annually (3 million US$), which is only a small fraction of the total cost of marketing. For comparison: On health information some 2 million Dan.kr. is spent annually by private associations. In 1970 and 1981 efforts were made to have a tobacco bill passed in the Danish Parliament-but with no success. Since 1972 there has been a gentleman's agreement between the ministry and the tobacco branch concerning the size and the content of tobacco advertising. The agreement was an evasive action initiated by the tobacco branch. During the tobacco bill debate in the Danish Parliament in 1981 the tobacco industry launched an aggressive and misleading advertising campaign in the large newspapers against the Minister of Interior. It says in the International Codes of Marketing Practice 1973 set forth by the International Chamber of Commerce: "all advertising should be legal, decent, honest and truthful" and "the advertisements should be prepared with due sense of social responsibility..".(ABSTRACT TRUNCATED AT 250 WORDS)

The Feminization of Poverty for Midlife and Older Women and Its Effects on Their Health.

ERIC Educational Resources Information Center

Porcino, Jane

There are 16.4 million women over age 65 in this country, compared to 11 million men. The 41 percent of this population who live alone are the poorest of the poor in this country, with an annual median income of just over $3,000 for white women and little more than $2,000 for black women. This abject poverty affects the ability of these women to…

Payday for payers. Compensation of the top execs at investor-owned insurers outpaced that of the leaders at hospitals and specialty care.

PubMed

Kutscher, Beth; Barr, Paul; Zigmond, Jessica

2012-08-13

Top executives at investor-owned hospital chains saw their compensation packages take a hit last year, amid the debt-ceiling crisis and concerns over how it might affect Medicare. Wayne Smith at Community Health Systems led the pack in that sector, with a $21 million payday, while Trevor Fetter, left, of Tenet, came in a distant second with $10.7 million.

Advanced technology meets mental health: how smartphones, textile electronics, and signal processing can serve mental health monitoring, diagnosis, and treatment.

PubMed

Valenza, Gaetano; Lanatà, Antonio; Paradiso, Rita; Scilingo, Enzo Pasquale

2014-01-01

Mental disorders, characterized by impaired emotional and mood balance, are common in the West. Recent surveys have found that millions of people (age 18?65) have experienced some kind of mental disorder, such as psychotic disorder, major depression, bipolar disorder, panic disorder, social phobia, and somatoform disorder [1]. Specifically, in 2010, 164.8 million people in Europe were affected by such illnesses [1].

Immigrant families changing the face of America and delivery of health care services.

PubMed

Waldman, H Barry

2008-01-01

15.7 million U.S. children, including more than 1.5 million New York State children, live in immigrant families. These newest arrivals are becoming a critical component of the changing demographics of the state's--and nation's--evolving population. A complex set of economic, social and cultural factors affect these youngsters and their families, which, in turn, can have an impact on the delivery of health services.

The Lice-Buster Book: What To Do When Your Child Comes Home with Head Lice!

ERIC Educational Resources Information Center

Copeland, Lennie

Noting that every year, 10 to 12 million children contract head lice, this book aims to demystify and provide information about the problem of head lice infestation of children. The first chapter gives statistical details about the problem and its effects on health. Chapter 2 provides factual information concerning the features, life-cycle,…

The prevalence of refractive errors among adults in the United States, Western Europe, and Australia.

PubMed

Kempen, John H; Mitchell, Paul; Lee, Kristine E; Tielsch, James M; Broman, Aimee T; Taylor, Hugh R; Ikram, M Kamran; Congdon, Nathan G; O'Colmain, Benita J

2004-04-01

To estimate the prevalence of refractive errors in persons 40 years and older. Counts of persons with phakic eyes with and without spherical equivalent refractive error in the worse eye of +3 diopters (D) or greater, -1 D or less, and -5 D or less were obtained from population-based eye surveys in strata of gender, race/ethnicity, and 5-year age intervals. Pooled age-, gender-, and race/ethnicity-specific rates for each refractive error were applied to the corresponding stratum-specific US, Western European, and Australian populations (years 2000 and projected 2020). Six studies provided data from 29 281 persons. In the US, Western European, and Australian year 2000 populations 40 years or older, the estimated crude prevalence for hyperopia of +3 D or greater was 9.9%, 11.6%, and 5.8%, respectively (11.8 million, 21.6 million, and 0.47 million persons). For myopia of -1 D or less, the estimated crude prevalence was 25.4%, 26.6%, and 16.4% (30.4 million, 49.6 million, and 1.3 million persons), respectively, of whom 4.5%, 4.6%, and 2.8% (5.3 million, 8.5 million, and 0.23 million persons), respectively, had myopia of -5 D or less. Projected prevalence rates in 2020 were similar. Refractive errors affect approximately one third of persons 40 years or older in the United States and Western Europe, and one fifth of Australians in this age group.

Qualitative dimension of the population problem.

PubMed

Gopalan, C

1983-01-26

In India there is a qualitative as well as a quantitative dimension to the population problem which should cause even greater concern and alarm and that is the steady deterioration of the physical and mental caliber of the country's "human resources." Of the nearly 23 million children who will be born in India in 1983, nearly 3 million may be expected to die. Less than 3 million of the 23 million will become truly healthy, physically fit, productive, and intellectually capable citizens. The qualitative dimension of the population problem is interrelated to the quantitative dimension in a mutually synergistic fashion. The persistent increase in numbers aggravates the qualitative deterioration, and the latter serves to facilitate such increase. Although it is imperative that in the national interest family planning programs and population control measures continue to receive highest priority, the problems of ill health and undernutrition among the poor will not be solved by these measures alone within the next 3 decades. Discussion focus is on the national nutrition and the national health scene and food production. The most recent reports of the National Nutrition Monitoring Bureau show that in nearly 85% of children under age 5, body weight is less than 80% of the normal values observed in well nourished Indian children not subject to socioeconomic constraints. At this time about 40 million people in India suffer from goiter, and iron deficiency anemia is widespread among the Indian population. Clearly, the nutrition factor needs to be given high priority in a population policy designed to promote national development. The infant mortality rate has remained stationary in the past decade (136/1000 in 1970 and 136/1000 in 1978), and the urban mortality rate declined from 90/1000 in 1970 to 70/1000 in 1978. There is now increasing concern in India over the possible erosion of the breastfeeding practice as a result of unethical and aggressive sales promotion campaigns of baby food manufacturers. Food grain production has increased over the past 2 decades, but there is no room for complacency. What is proposed is an imaginative special program to be instituted in India's rural areas and directed to young unmarried girls of 10 years of age or older. It should include a special 2-year education program on infant feeding and child rearing, nutrition, family planning, personal and environmental hygiene, and vocational training designed to impart special skills for self employment in selected fields appropriate to the particular rural area.

Environmental refugees: a growing phenomenon of the 21st century.

PubMed Central

Myers, Norman

2002-01-01

There is a new phenomenon in the global arena: environmental refugees. These are people who can no longer gain a secure livelihood in their homelands because of drought, soil erosion, desertification, deforestation and other environmental problems, together with the associated problems of population pressures and profound poverty. In their desperation, these people feel they have no alternative but to seek sanctuary elsewhere, however hazardous the attempt. Not all of them have fled their countries, many being internally displaced. But all have abandoned their homelands on a semi-permanent if not permanent basis, with little hope of a foreseeable return. In 1995, environmental refugees totalled at least 25 million people, compared with 27 million traditional refugees (people fleeing political oppression, religious persecution and ethnic troubles). The total number of environmental refugees could well double by the year 2010, and increase steadily for a good while thereafter as growing numbers of impoverished people press ever harder on overloaded environments. When global warming takes hold, there could be as many as 200 million people overtaken by sea-level rise and coastal flooding, by disruptions of monsoon systems and other rainfall regimes, and by droughts of unprecedented severity and duration. PMID:12028796

Arsenic in the environment: Biology and chemistry

USGS Publications Warehouse

Bhattacharya, Prosun; Welch, Alan H.; Stollenwerk, Kenneth G.; McLaughlin , Mike J.; Bundschuh, Jochen; Panaullah, G.

2007-01-01

Arsenic (As) distribution and toxicology in the environment is a serious issue, with millions of individuals worldwide being affected by As toxicosis. Sources of As contamination are both natural and anthropogenic and the scale of contamination ranges from local to regional. There are many areas of research that are being actively pursued to address the As contamination problem. These include new methods of screening for As in the field, determining the epidemiology of As in humans, and identifying the risk of As uptake in agriculture. Remediation of As-affected water supplies is important and research includes assessing natural remediation potential as well as phytoremediation. Another area of active research is on the microbially mediated biogeochemical interactions of As in the environment.In 2005, a conference was convened to bring together scientists involved in many of the different areas of As research. In this paper, we present a synthesis of the As issues in the light of long-standing research and with regards to the new findings presented at this conference. This contribution provides a backdrop to the issues raised at the conference together with an overview of contemporary and historical issues of As contamination and health impacts.

Improving quality of life in multiple sclerosis: an unmet need.

PubMed

Zwibel, Howard L; Smrtka, Jennifer

2011-05-01

Multiple sclerosis (MS) affects approximately 400,000 people in the United States and 2.1 million people worldwide. It is the most common chronic, non-traumatic neurological disorder afflicting young people during their peak productive ages. MS can diminish quality of life (QOL) by interfering with the ability to work, pursue leisure activities, and carry on usual life roles. Symptoms that affect QOL may include impaired mobility, fatigue, depression, pain, spasticity, cognitive impairment, sexual dysfunction, bowel and bladder dysfunction, vision and hearing problems, seizures, and sDwallowing and breathing difficulties. Direct medical costs of MS in the United States are estimated in excess of $10 billion per year. Indirect costs of MS include costs of reduced employment or unemployment, assistive equipment, disability related home modifications, and paid and unpaid personal care. Although direct medical costs predominate in the earlier stages of MS, indirect costs of productivity loss are responsible for higher costs later. Disease-modifying therapies (DMTs) lessen symptoms, reduce relapses, and delay disability progression. Unfortunately, many DMTs might produce only modest improvements in QOL. Although symptom-specific therapies do not delay disease progression, they may delay unemployment and dependency, thereby reducing indirect costs.

Multi-targetable chalcone analogs to treat deadly Alzheimer's disease: Current view and upcoming advice.

PubMed

Zhang, Xu; Rakesh, K P; Bukhari, S N A; Balakrishna, Moku; Manukumar, H M; Qin, Hua-Li

2018-06-05

The complications of Alzheimer's disease AD were deadly dangerous cause of neurodegenerative disorders connected with the decline of the cognitive functions and loss of memory. The common form of dementia is accounted as the sixth leading cause of the death affecting any stage of people in a lifetime. Synthetic natural chalcone analogs were currently a hot research topic for the treatment of (AD) which has affected millions of peoples throughout the world. The present aim was set to understand the important problems of the AD and its treatment based on natural derivatives of novel chalcones. One interesting strategy currently of searching for the treatment of AD is to find inhibitors for acetylcholinesterase (AChE) and using metal chelators to target amyloid-β (Aβ) peptides, and then metal-Aβ complexes for the AD pathogenesis. The present compressed review focuses and highlights the design and synthesis of new approaches for the construction of important chalcones playing multiple beneficiary roles in the AD treatments. These hallmarks of concurred research represent the immediate needs of development of novel therapeutic drugs for effective treatment of ADs by understanding the specific pharmacology targets. Copyright © 2018 Elsevier Inc. All rights reserved.

Economic impact of corrosion and scaling problems in geothermal energy systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shannon, D.W.

Corrosion and scaling problems have a significant impact on geothermal plant economics. A power plant must amortize the capital investment over a 20-year period and achieve satisfactory operating efficiency to achieve financial success. Corrosion and scale incrustations have been encountered in all geothermal plants, and to various degrees, adversely affected plant life times and power output. Using published data this report analyzes known geothermal corrosion and scaling phenomena for significant cost impacts on plant design and operation. It has been necessary to speculate about causes and mechanisms in order to estimate impacts on conceptual geothermal plants. Silica is highly solublemore » in hot geothermal water and solubility decreases as water is cooled in a geothermal power plant. Calculations indicate as much as 30,000 tons/year could pass through a 100 MWe water cycle plant. The major cost impact will be on the reinjection well system where costs of 1 to 10 mills/kwhr of power produced could accrue to waste handling alone. On the other hand, steam cycle geothermal plants have a definite advantage in that significant silica problems will probably only occur in hot dry rock concepts, where steam above 250 C is produced. Calculation methods are given for estimating the required size and cost impact of a silica filtration plant and for sizing scrubbers. The choice of materials is significantly affected by the pH of the geothermal water, temperature, chloride, and H{sub s} contents. Plant concepts which attempt to handle acid waters above 180 C will be forced to use expensive corrosion resistant alloys or develop specialized materials. On the other hand, handling steam up to 500 C, and pH 9 water up to 180 C appears feasible using nominal cost steels, typical of today's geothermal plants. A number of factors affecting plant or component availability have been identified. The most significant is a corrosion fatigue problem in geothermal turbines at the Geyser's geothermal plant which is presently reducing plant output by about 10%. This is equivalent to over $3 million per year in increased oil consumption to replace the power. In the course of assessing the cost implications of corrosion and scaling problems, a number of areas of technological uncertainty were identified which should be considered in R and D planning in support of geothermal energy. Materials development with both laboratory and field testing will be necessary. The economic analysis on which this report is based was done in support of an AEC Division of Applied Technology program to assess the factors affecting geothermal plant economics. The results of this report are to be used to develop computer models of overall plant economics, of which corrosion and scaling problems are only a part. The translation of the economic analysis to the report which appears here, was done on AEC Special Studies Funds.« less

Modeling and Simulation at Tidewater Community College

NASA Technical Reports Server (NTRS)

Summers, Michael

2008-01-01

Investment of $1.5 million in medical simulation technology. Integration of medical simulation activities into the curriculum. Support from TCC leadership. Individual and team activities. Skill development and critical thinking/problem solving skills.

Green technologies for reducing slope erosion.

DOT National Transportation Integrated Search

2010-01-01

As climate change alters precipitation patterns, departments of transportation will increasingly face the problem of : slope failures, which already cost California millions of dollars in repair work annually. Caltrans hopes to prevent : these failur...

Heart Disease (For Kids)

MedlinePlus

... blood vessels. You might know someone who has cardiovascular disease because more than 60 million Americans have some ... The blood carries oxygen, which the cells need. Cardiovascular disease is a group of problems that occur when ...

Finland's Cleanup Campaign

ERIC Educational Resources Information Center

Environmental Science and Technology, 1975

1975-01-01

Finland has received a $20 million loan from the World Bank to attack its pollution problems, mainly water. Improved quality of life, as well as resource conservation are both motives and goals of that country's environmental programs. (BT)

Rethinking impact evaluation and carbon reduction analysis on electric bus vehicles in China

NASA Astrophysics Data System (ADS)

Li, Zhenyu; Li, Chao; Liao, Kai; Yin, Zhifang

2018-02-01

New energy bus vehicles (NEBVs) are expanding in China, but they have some problems such as technology, high cost and safety etc., thus NEBVs should be comprehensively evaluated from costs, technologies, environment, and based on the evaluation results, some changes should be improved. This paper firstly analyses the current status of both vehicle development and existing policies, identifies the main characteristics and the main problems in term of the economic, standard, policy, etc., by scenario analysis, forecasts the future growth from now to 2030 and calculates the emission reduction in low level scenario and high level scenario. In 2020 and 2030, 6 million and 24 million ton of CO2 emission will be reduced respectively. Finally, the paper makes a conclusion of Chinese experiences and gives some measures for the future development.

AIDS: new threat to the third world.

PubMed

Heise, L

1988-01-01

Acquired immuneodeficiency syndrome (AIDS) threatens to have a catastrophic historical impact on the 3rd world, undermining decades of progress toward improved health and sustained economic development. By 1986, the World Health Organization (WHO) estimate between 5 and 10 million people worldwide were carriers. By 1990, WHO projects 50 to 100 million may be infected, leaving 15 to 30 million dead by 1995. The extent of AIDS cases in LDCs is most likely underreported as these countries already have limited access to health care. The infection rate could be 100 times higher in African cities than in the US as a whole. With an estimated 2 million infected, Africa is the hardest hit region in the world; Asia is the least affected with Japan having the highest number of reported cases at 43. Overall rate of transmission is likely to remain higher in the 3rd world for numerous reasons including the prevalence of sexually transmitted diseases, lack of money to screen blood for transfusions, high number of sexual partners due to socio-economic conditions, chronic exposure to viral and parasitic infections, and unhygienic conditions. Unlike developed nations, LDCs do not have the health care budgets to care for the opportunistic infections of AIDS patients. Therefore they often are subject to triage, passed over in favor of patients with curable diseases. AIDS provides an even greater threat as a multiplier of existing but dormant diseases such as tuberculosis. AIDS will undermine the decades of progress in maternal and child health and may soon be significant factor in the mother/child survival quotient. Some African cities report that 8 to 14% of women attending prenatal clinics test positive. Since it strikes the most productive age group--those between 20 and 49-- AIDS threatens to undermine the economies of LDCs at a time when most LDCsa are already struggling. Meeting the global challenge of AIDS will requre unprecedented international cooperation. The fact that both 1st and 3rd world countries must face the problem could lead to the necessary efforts.

The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity.

PubMed

Beck, Stacy; Wojdyla, Daniel; Say, Lale; Betran, Ana Pilar; Merialdi, Mario; Requejo, Jennifer Harris; Rubens, Craig; Menon, Ramkumar; Van Look, Paul F A

2010-01-01

To analyse preterm birth rates worldwide to assess the incidence of this public health problem, map the regional distribution of preterm births and gain insight into existing assessment strategies. Data on preterm birth rates worldwide were extracted during a previous systematic review of published and unpublished data on maternal mortality and morbidity reported between 1997 and 2002. Those data were supplemented through a complementary search covering the period 2003-2007. Region-specific multiple regression models were used to estimate the preterm birth rates for countries with no data. We estimated that in 2005, 12.9 million births, or 9.6% of all births worldwide, were preterm. Approximately 11 million (85%) of these preterm births were concentrated in Africa and Asia, while about 0.5 million occurred in each of Europe and North America (excluding Mexico) and 0.9 million in Latin America and the Caribbean. The highest rates of preterm birth were in Africa and North America (11.9% and 10.6% of all births, respectively), and the lowest were in Europe (6.2%). Preterm birth is an important perinatal health problem across the globe. Developing countries, especially those in Africa and southern Asia, incur the highest burden in terms of absolute numbers, although a high rate is also observed in North America. A better understanding of the causes of preterm birth and improved estimates of the incidence of preterm birth at the country level are needed to improve access to effective obstetric and neonatal care.

Pneumonia (image)

MedlinePlus

Pneumonia is an inflammation of the lungs caused by an infection. Many different organisms can cause it, including bacteria, viruses, and fungi. Pneumonia is a common illness that affects millions of ...

Exercise, Eating, Estrogen, and Osteoporosis.

ERIC Educational Resources Information Center

Brown, Jim

1986-01-01

Osteoporosis affects millions of people, especially women. Three methods for preventing or managing osteoporosis are recommended: (1) exercise; (2) increased calcium intake; and (3) estrogen replacement therapy. (CB)

Development of a health promotion programme to improve awareness of factors that affect fertility, and evaluation of its reach in the first 5 years.

PubMed

Hammarberg, Karin; Norman, Robert J; Robertson, Sarah; McLachlan, Robert; Michelmore, Janet; Johnson, Louise

2017-06-01

Awareness among people of reproductive age about the factors that influence fertility and reproductive outcomes, including medically assisted reproduction outcomes, is generally low. To improve awareness about the potentially modifiable factors that affect fertility and reproductive outcomes, 'Your Fertility', a fertility health promotion programme funded by the Australian Government, was established in 2011. This paper describes the development and evaluation of the reach of the Your Fertility programme from its inception in 2011 to June 2016. Systematically recorded outcomes for the programme's key focus areas and Google Analytics data were collated. Key achievements include developing and maintaining an internationally renowned website that experiences high growth and demand for fertility-related information; by 2016, over 5 million users had viewed more than 10 million webpages, and over 96,000 users had engaged in programme messages across social media. Programme messages have reached more than 4 million Australian social media users, and a potential audience of 150 million through media coverage across more than 320 media features. More than 4200 education and health professionals have completed online learning modules, and external partnerships have been established with 14 separate organizations. Data collected over 5 years indicate that the Your Fertility programme meets a need for targeted, evidence-based, accessible fertility-related information.

The indirect costs of agency nurses in South Africa: a case study in two public sector hospitals.

PubMed

Rispel, Laetitia C; Moorman, Julia

2015-01-01

Globally, flexible work arrangements - through the use of temporary nursing staff - are an important strategy for dealing with nursing shortages in hospitals. The objective of the study was to determine the direct and indirect costs of agency nurses, as well as the advantages and the problems associated with agency nurse utilisation in two public sector hospitals in South Africa. Following ethical approval, two South African public sector hospitals were selected purposively. Direct costs were determined through an analysis of hospital expenditure information for a 5-year period from 2005 until 2010, obtained from the national transversal Basic Accounting System database. At each hospital, semi-structured interviews were conducted with the chief executive officer, executive nursing services manager, the maternity or critical care unit nursing manager, the human resource manager, and the finance manager. Indirect costs measured were the time spent on pre-employment checks, and nurse recruitment, orientation, and supervision. All expenditure is expressed in South African Rands (R: 1 USD=R7, 2010 prices). In the 2009/10 financial year, Hospital 1 spent R38.86 million (US$5.55 million) on nursing agencies, whereas Hospital 2 spent R10.40 million (US$1.49 million). The total estimated time spent per week on indirect cost activities at Hospital 1 was 51.5 hours, and 60 hours at Hospital 2. The estimated monetary value of this time at Hospital 1 was R962,267 (US$137,467) and at Hospital 2 the value was R300,121 (US$42,874), thus exceeding the weekly direct costs of nursing agencies. Agency nurses assisted the selected hospitals in dealing with problems of nurse recruitment, absenteeism, shortages, and skills gaps in specialised clinical areas. The problems experienced with agency nurses included their perceived lack of commitment, unreliability, and providing sub-optimal quality of patient care. Hospital managers and policy-makers need to address the effective utilisation of agency nurses and quality of patient care in tandem.

Problems with drugs in Croatia.

PubMed

Vrhovac, B

1997-01-01

Croatia has 4.8 million inhabitants, 11,800 physicians, 2000 pharmacists, two now shareholding, pharmaceutical companies (about 6500 employees, total sales of about 350 million US dollars). There are a number of problems due to the war (GNP fell from 3800 to about 1500 US dollars), occupation of 25% of its territory, 0.5 million refugees and lack of resources (139 US dollars/capita for health, about 40 US dollars i.e. 30%!! for drugs)--about three times less than before the aggression. The drug situation is controlled with the help of: (1) donations (approximate value of 600 million US dollars since 1991 from Europe and US), (2) (essential) drug formularies--250 for outpatients, and 580 generic names for various levels of hospital use, (3) special efforts to purchase drugs of good quality at a reasonable price (a kind of tender), (4) control of prescribing (prescriptions, specialists referral) especially by GPs. A new Medicines Act is in preparation and about 1000 generic names are on the market. DRUG EDUCATION: Pharmaca: the Croatian journal of pharmacotherapy has been published since 1962, there are several Drug bulletins (one published since 1975); special chapters on clinical pharmacology in textbooks, translation of three editions of Laurence's textbook with special commentary and adaptation to local needs; ADR spontaneous and intensive monitoring (WHO programme) with a personal feedback to the reporters and regular articles on drug use in a number of periodicals. Data on drug consumption indicates that there is room for improvement of prescribing. There is an enthusiasm for 'vasoactive drugs'--after dipirydamole came oxpentifylline and antimicrobials are always overprescribed. All these problems will hopefully decrease when the war finally stops and when industry (especially tourism) starts being fruitful again. In any case the importance of teaching of pharmacotherapy at the under- and postgraduate level should be recognized. Copyright 1997 by John Wiley & Sons, Ltd.

Cost Assessment of Hepatitis B Virus-related Hepatitis in Bangladesh.

PubMed

Mahtab, Mamun Al; Chaudhury, Muntasir; Uddin, Mohammad H; Noor-E Alam, Sheikh M; Rahim, Mohammad A; Alam, Mohammad A; Moben, Ahmed L; Khondaker, Faiz A; Choudhury, Mohammad Fi; Sarkar, Mohammad Ja; Poddar, Provat K; Foez, Syed A; Akbar, Sheikh Mf

2016-01-01

Hepatitis B virus (HBV) infection is endemic in Bangladesh. Studies have indicated that HBV is the major cause of chronic hepatitis B (CHB), liver cirrhosis (LC), and hepatocellular carcinoma (HCC) in this country. Recently, HBV-related acute on chronic liver failure (HBV-ACLF) has emerged as a serious and emergent medical problem in Bangladesh. To develop a strategy to address HBV-related problems and their influence on health care delivery system, proper understandings about extent of problems and nature of economic burden should be explored. Conservative estimates indicate that about 50 million or more of Bangladeshi have been infected by HBV at some point of their life. Out of the total Bangladeshi population, about 2 to 5% is chronically infected with HBV (about 3-8 million) (1-6%) and considerable number of these patients will eventually develop LC, HCC, or ACLF (about 1 million). Although proper statistics is lacking, it is estimated that HBV-related liver diseases account for a majority of hospital admissions and around 20,000 deaths every year in Bangladesh. In addition, complex clinical features of HBV-related liver diseases have been documented in Bangladesh that show similarity and differences from HBV infection in other Asian countries. Although vaccination against HBV and containment of horizontal transmission are in progress in Bangladesh for reduction of new HBV infection, there is a lack of national strategy for treatment of millions of chronic HBV-infected subjects. This paper will provide an insight regarding the economic impact of HBV in Bangladesh that may act as a primary impetus for developing national HBV eradication program, a goal set by World Health Organization (WHO). Al Mahtab M, Chaudhury M, Uddin MH, Noor-E-Alam SM, Rahim MA, Alam MA, Moben AL, Khondaker FA, Choudhury MFI, Sarkar MJA, Poddar PK, Foez SA, Akbar SMF. Cost Assessment of Hepatitis B Virus-related Hepatitis in Bangladesh. Euroasian J Hepato-Gastroenterol 2016;6(2):163-166.

Sub-Saharan Africa Report

DTIC Science & Technology

1987-02-20

from Tanzania; and the worsening of the country’s social and economic crisis, wherein famine has already affected millions of people, creating a...life of our citizens. As everyone is aware, the hunger and poverty have contiuued. The 60,000 Adventists in the country were as rauch affected by the... affected by the criminal actions of the armed bandits, the security system has been strengthened. This is being done by militiamen, together with

Vantage point.

PubMed

Kay, Jenny

2007-12-01

It is estimated that 2 million people in England and Wales lack, at some time in their lives, sufficient mental capacity to make decisions for themselves. They include people with dementia, learning disabilities, mental health problems, stroke or head injuries.

Migration from rural to urban areas in China.

PubMed

Wakabayashi, K

1990-12-01

During the regime of Mao Zedong the migration of rural population to urban areas was forbidden. In 1982 the people's communes were dissolved creating surplus labor. In 1984 permission was given to peasants to move to towns of 100,000 inhabitants or less. In 1986 the state allocation of jobs and lifetime employment practices were abolished leading to the migration of peasants. Urban population has increased 30-50 million annually since 1985. In 1988-89 urban population consisted of urban registry holders numbering 200 million protected by the government, 100 million new residents unqualified for food rations who had moved into towns of 100,000 population, and the so-called floating population getting no government services numbering about 60-80 million in February 1990. Rural towns grew as a result of promotion of smaller sized cities. In 1983 there were 62,310,000 people in such cities, and by 1984 there were over 134 million mainly in the 15-29 age group. The increasing inflow of population into major cities also occurred in 1984-5 owing to the dissolution of communes. 23 cities with populations over 1 million received 10 million migrants/year, and 50 million migrate to towns and cities every year. In 1988 Shanghai had a mostly male floating population of 2.08 million/year, and Beijing had 1,310,000. This phenomenon led to the emergence of surplus agricultural labor. Village and township enterprises absorbed this surplus: in 1988 there were 18,888,600 such entities employing 95,454,600 people or 23.8% of the labor force. Surplus labor totals 220 million out of 400 million agricultural labor force. The gap between the hinterland and the rich coastal areas with special economic zones is widening, reminiscent of the north-south problem. This phenomenon is the harbinger of the transformation of China into a freer society with higher population mobility.

[Human and animal fascioliasis in Peru: impact in the economy of endemic zones].

PubMed

Espinoza, José R; Terashima, Angélica; Herrera-Velit, Patricia; Marcos, Luis A

2010-01-01

Fasciola hepatica is the causative agent of fasciolosis in Peru; the disease is an important public health problem by the high prevalence of the human infection affecting mainly children and a major veterinary problem by the high rates of infected livestock. The human disease is endemic in the Sierra and the Coast but sporadic in the Amazonia, and reported in 18 Departments, while the animal infection in 21 of 24 Departments of Peru. Transmission occurs in Andean rural populations engaged in agriculture, but recently an increasing number of people became infected in the cities. The epidemiological situation in Peru includes i) Departments with non-autochtonous cases, where infection occurs by consumption of contaminated vegetables brought from endemic areas or infection is acquired by visit to endemic areas; ii) Departments with hypoendemic and mesoendemic villages, where transmission occurs by ingest of contaminated vegetables and prevalence ≤10%; and iii) Departments with hyper-endemic villages with human prevalence >10 %, with an intense transmission by consumption of contaminated vegetables. The disease affects bovine, sheep, goat, swine, equine, South American camelids, rabbits and guinea pigs. The negative impact of fasciolosis in the livestock economy is not lesser than US$ 50 million per year, estimation based on the prevalence and the number of condemned livers in the abattoirs. It is difficult to estimate the economic impact of this infection in the human health due to its status of neglected disease, but fasciolosis is hyper-endemic in the poorest Andean areas of Peru where the situation has to be recognized as a public health emergency.

Who will cover the cost of undocumented immigrant trauma care?

PubMed

Mitchell, Christopher D; Truitt, Michael S; Shifflette, Vanessa K; Johnson, Van; Mangram, Alicia J; Dunn, Ernest L

2012-03-01

Health care reform under the "Patient Protection and Affordable Care Act" (PPACA) will lead to changes in reimbursement. Although this legislation provides a mechanism for uninsured Americans to obtain coverage, it excludes undocumented immigrants (UDI). Reimbursement for UDIs comes from the disproportionate share hospital (DSH) program and was previously supported by Section-1011 of the 2003 Medicare Modernization Act (S1011). The PPACA details a cut of DSH funds starting in 2014. This could impose a significant financial burden on trauma centers. From May 2005 to May 2008, we retrospectively reviewed all trauma-related emergency room visits by UDIs. We quantified charges for three entities: emergency department physicians, trauma surgeons, and the hospital. We applied our average institutional collection rate to these charges and compared these projected collections with the actual collections. Over a three-year period, we identified 1,325 trauma UDIs. The financial records revealed a projected emergency department physicians collection of $452,686, a projected trauma surgeons collection of $1.2 million, and a projected hospital collection of $6.9 million (total $8.6 million). Actual funding from S1011 provided $1.7 million and DSH provided $1.9 million (total $3.6 million). Texas State Funding and UDI self-payment contributed $611,082. Overall, our institution had a reimbursement discrepancy of $4.3 million with DSH/S1011 assistance. This increased to $6.0 million after the termination of S1011 and may increase to $7.9 million under PPACA. These figures underestimate the total cost of UDI trauma care as it only includes three entities. Our data represent a fraction of national figures. Failure to address these issues could result in ongoing financial problems for trauma centers. II, economic and decision analysis.

Evaluating Behavioral Health Surveillance Systems.

PubMed

Azofeifa, Alejandro; Stroup, Donna F; Lyerla, Rob; Largo, Thomas; Gabella, Barbara A; Smith, C Kay; Truman, Benedict I; Brewer, Robert D; Brener, Nancy D

2018-05-10

In 2015, more than 27 million people in the United States reported that they currently used illicit drugs or misused prescription drugs, and more than 66 million reported binge drinking during the previous month. Data from public health surveillance systems on drug and alcohol abuse are crucial for developing and evaluating interventions to prevent and control such behavior. However, public health surveillance for behavioral health in the United States has been hindered by organizational issues and other factors. For example, existing guidelines for surveillance evaluation do not distinguish between data systems that characterize behavioral health problems and those that assess other public health problems (eg, infectious diseases). To address this gap in behavioral health surveillance, we present a revised framework for evaluating behavioral health surveillance systems. This system framework builds on published frameworks and incorporates additional attributes (informatics capabilities and population coverage) that we deemed necessary for evaluating behavioral health-related surveillance. This revised surveillance evaluation framework can support ongoing improvements to behavioral health surveillance systems and ensure their continued usefulness for detecting, preventing, and managing behavioral health problems.

The baby boomer effect: changing patterns of substance abuse among adults ages 55 and older.

PubMed

Duncan, David F; Nicholson, Thomas; White, John B; Bradley, Dana Burr; Bonaguro, John

2010-07-01

Between now and 2030, the number of adults aged 65 and older in the United States will almost double, from around 37 million to more than 70 million, an increase from 12% of the U.S. population to almost 20%. It was long held that, with only a few isolated exceptions, substance abuse simply did not exist among this population. In light of the impact of the baby boom generation, this assumption may no longer be valid. The authors examined admissions of persons 55 years and older (n = 918,955) from the Treatment Episode Data Set (1998-2006). Total admissions with a primary drug problem with alcohol have remained relatively stable over this time. Admissions for problems with a primary drug other than alcohol have shown a steady and substantial increase. Clearly, data from the Treatment Episode Data Set indicate a coming wave of older addicts whose primary problem is not alcohol. The authors suspect that this wave is led primarily by the continuing emergence of the baby boomer generation.

Evaluating Behavioral Health Surveillance Systems

PubMed Central

Azofeifa, Alejandro; Lyerla, Rob; Largo, Thomas; Gabella, Barbara A.; Smith, C. Kay; Truman, Benedict I.; Brewer, Robert D.; Brener, Nancy D.

2018-01-01

In 2015, more than 27 million people in the United States reported that they currently used illicit drugs or misused prescription drugs, and more than 66 million reported binge drinking during the previous month. Data from public health surveillance systems on drug and alcohol abuse are crucial for developing and evaluating interventions to prevent and control such behavior. However, public health surveillance for behavioral health in the United States has been hindered by organizational issues and other factors. For example, existing guidelines for surveillance evaluation do not distinguish between data systems that characterize behavioral health problems and those that assess other public health problems (eg, infectious diseases). To address this gap in behavioral health surveillance, we present a revised framework for evaluating behavioral health surveillance systems. This system framework builds on published frameworks and incorporates additional attributes (informatics capabilities and population coverage) that we deemed necessary for evaluating behavioral health–related surveillance. This revised surveillance evaluation framework can support ongoing improvements to behavioral health surveillance systems and ensure their continued usefulness for detecting, preventing, and managing behavioral health problems. PMID:29752804

Mixed signals: trends in Americans' access to medical care, 2007-2010.

PubMed

Boukus, Ellyn R; Cunningham, Peter J

2011-08-01

Likely reflecting the severe economic downturn and subsequent decline in demand for health care, the number and proportion of Americans reporting going without or delaying needed medical care declined modestly between 2007 and 2010, according to findings from the Center for Studying Health System Change's (HSC) nationally representative 2010 Health Tracking Household Survey. Despite increases in the number of uninsured, slightly more than one in six Americans--52 million people--reported not getting or delaying needed medical care in 2010, down from one in five--58.6 million people--in 2007. The decline was driven primarily by fewer access problems for insured people, likely reflecting recession-related decreases in the demand for medical care. Nevertheless, the access gap between insured and uninsured people widened in 2010 compared to 2007, especially for lower-income people and those with health problems. Among people reporting problems getting medical care, the cost of care was an even bigger concern than in previous years. Fewer people encountered health system-related barriers, such as getting timely appointments with doctors, possibly reflecting freed-up health system capacity because of lower demand.

Poultry production's environmental impact on water quality.

PubMed

Pope, C W

1991-05-01

Poultry meat and eggs are rapidly becoming the major source of animal protein in the diets of American consumers. Such expansion has resulted in a similar increase in waste management problems. The national production of broilers and mature chickens was 5.68 billion, 242 million turkeys, 31 million ducks, and 69 trillion table eggs in 1989 based on the USDA National Statistics Survey. Annual production of fecal waste from poultry flocks was 8.8 million tons on a dry weight basis plus more than 106,000 metric tons of broiler hatchery waste. Add to this 37 million dead birds and condemnations at processing plants (figures are also from USDA for 1989 based on USDA National Statistics Survey). When all this waste is added together, the task of keeping the environment clean becomes monumental. The following waste management practices can and must take care of these poultry industry waste products: sanitary land fills, rendering facilities, extrusion machinery, compost plants, lagoons or holding tanks, and land application techniques.

Understanding Refugees' Health.

PubMed

Müller, Martin; Khamis, Dana; Srivastava, David; Exadaktylos, Aristomenis K; Pfortmueller, Carmen Andrea

2018-04-01

According to the United Nations Refugee Agency (UNHCR), 65.6 million people have been forcibly displaced worldwide. Several factors have a major influence on asylum seekers' health; so, their health profile is markedly different from that of the population in the country of asylum. The aim of this study is to review the major issues physicians need to be aware of when treating asylum seekers, with a special focus on the neurological problems of asylum seekers and refugees. The major impact factors on refugees' health are linked to experiences and exposure (1) in the country of origin, (2) in refugee camps and en route to Europe, and (3) in the process of immigration into the host country and living in European asylum centers. Refugees' health is also affected by psychological problems and by infectious diseases. Additionally, chronic diseases resulting in polymorbidity, cancer, and neurological diseases are easy to overlook and demand special attention. Neurological injuries/diseases may be traumatic (e.g., spinal cord injuries), posttraumatic (e.g., chronic pain syndromes), the result of cerebral infections, or the consequences of starvation (e.g., epilepsy, ataxia, and paraesthesia). The main challenges for physicians are lack of awareness of the asylum seekers' specific health care problems, language and intercultural communication problems, as well as access and integration of asylum seekers into the health care system. The health issues of asylum seekers are manifold and challenging to physicians. Awareness of these conditions is mandatory to ensure good clinical practice for this patient population, which has a huge burden in chronic, infectious, mental, and neurological diseases. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Hydrogeology, distribution, and volume of saline groundwater in the southern midcontinent and adjacent areas of the United States

USGS Publications Warehouse

Osborn, Noël I.; Smith, S. Jerrod; Seger, Christian H.

2013-01-01

The hydrogeology, distribution, and volume of saline water in 22 aquifers in the southern midcontinent of the United States were evaluated to provide information about saline groundwater resources that may be used to reduce dependency on freshwater resources. Those aquifers underlie six States in the southern midcontinent—Arkansas, Kansas, Louisiana, Missouri, Oklahoma, and Texas—and adjacent areas including all or parts of Alabama, Colorado, Florida, Illinois, Kentucky, Mississippi, Nebraska, New Mexico, South Dakota, Tennessee, and Wyoming and some offshore areas of the Gulf of Mexico. Saline waters of the aquifers were evaluated by defining salinity zones; digitizing data, primarily from the Regional Aquifer-System Analysis Program of the U.S. Geological Survey; and computing the volume of saline water in storage. The distribution of saline groundwater in the southern midcontinent is substantially affected by the hydrogeology and groundwater-flow systems of the aquifers. Many of the aquifers in the southern midcontinent are underlain by one or more aquifers, resulting in vertically stacked aquifers containing groundwaters of varying salinity. Saline groundwater is affected by past and present hydrogeologic conditions. Spatial variation of groundwater salinity in the southern midcontinent is controlled primarily by locations of recharge and discharge areas, groundwater-flow paths and residence time, mixing of freshwater and saline water, and interactions with aquifer rocks and sediments. The volume calculations made for the evaluated aquifers in the southern midcontinent indicate that about 39,900 million acre-feet (acre-ft) of saline water is in storage. About 21,600 million acre-ft of the water in storage is slightly to moderately saline (1,000–10,000 milligrams per liter [mg/L] dissolved solids), and about 18,300 million acre-ft is very saline (10,000–35,000 mg/L dissolved solids). The largest volumes of saline water are in the coastal lowlands (about 16,300 million acre-ft), Mississippi embayment and Texas coastal uplands (about 12,000 million acre-ft), and Great Plains (about 8,170 million acre-ft) aquifer systems. Of the 22 aquifers evaluated in this report, the Maha aquifer in the Great Plains aquifer system contains both the largest total volume of saline water (about 6,280 million acre-ft) and the largest volume of slightly to moderately saline water (about 5,150 million acre-ft).

Malaria and large dams in sub-Saharan Africa: future impacts in a changing climate.

PubMed

Kibret, Solomon; Lautze, Jonathan; McCartney, Matthew; Nhamo, Luxon; Wilson, G Glenn

2016-09-05

Sub-Saharan Africa (SSA) has embarked on a new era of dam building to improve food security and promote economic development. Nonetheless, the future impacts of dams on malaria transmission are poorly understood and seldom investigated in the context of climate and demographic change. The distribution of malaria in the vicinity of 1268 existing dams in SSA was mapped under the Intergovernmental Panel on Climate Change (IPCC) representative concentration pathways (RCP) 2.6 and 8.5. Population projections and malaria incidence estimates were used to compute population at risk of malaria in both RCPs. Assuming no change in socio-economic interventions that may mitigate impacts, the change in malaria stability and malaria burden in the vicinity of the dams was calculated for the two RCPs through to the 2080s. Results were compared against the 2010 baseline. The annual number of malaria cases associated with dams and climate change was determined for each of the RCPs. The number of dams located in malarious areas is projected to increase in both RCPs. Population growth will add to the risk of transmission. The population at risk of malaria around existing dams and associated reservoirs, is estimated to increase from 15 million in 2010 to 21-23 million in the 2020s, 25-26 million in the 2050s and 28-29 million in the 2080s, depending on RCP. The number of malaria cases associated with dams in malarious areas is expected to increase from 1.1 million in 2010 to 1.2-1.6 million in the 2020s, 2.1-3.0 million in the 2050s and 2.4-3.0 million in the 2080s depending on RCP. The number of cases will always be higher in RCP 8.5 than RCP 2.6. In the absence of changes in other factors that affect transmission (e.g., socio-economic), the impact of dams on malaria in SSA will be significantly exacerbated by climate change and increases in population. Areas without malaria transmission at present, which will transition to regions of unstable transmission, may be worst affected. Modifying conventional water management frameworks to improve malaria control, holds the potential to mitigate some of this increase and should be more actively implemented.

UK investments in global infectious disease research 1997-2010: a case study.

PubMed

Head, Michael G; Fitchett, Joseph R; Cooke, Mary K; Wurie, Fatima B; Hayward, Andrew C; Atun, Rifat

2013-01-01

Infectious diseases account for 15 million deaths per year worldwide, and disproportionately affect young people, elderly people, and the poorest sections of society. We aimed to describe the investments awarded to UK institutions for infectious disease research. We systematically searched databases and websites for information on research studies from funding institutions and created a comprehensive database of infectious disease research projects for the period 1997-2010. We categorised studies and funding by disease, cross-cutting theme, and by a research and development value chain describing the type of science. Regression analyses were reported with Spearman's rank correlation coefficient to establish the relation between research investment, mortality, and disease burden as measured by disability-adjusted life years (DALYs). We identified 6170 funded studies, with a total research investment of UK£2·6 billion. Studies with a clear global health component represented 35·6% of all funding (£927 million). By disease, HIV received £461 million (17·7%), malaria £346 million (13·3%), tuberculosis £149 million (5·7%), influenza £80 million (3·1%), and hepatitis C £60 million (2·3%). We compared funding with disease burden (DALYs and mortality) to show low levels of investment relative to burden for gastrointestinal infections (£254 million, 9·7%), some neglected tropical diseases (£184 million, 7·1%), and antimicrobial resistance (£96 million, 3·7%). Virology was the highest funded category (£1 billion, 38·4%). Leading funding sources were the Wellcome Trust (£688 million, 26·4%) and the Medical Research Council (£673 million, 25·8%). Research funding has to be aligned with prevailing and projected global infectious disease burden. Funding agencies and industry need to openly document their research investments to redress any inequities in resource allocation. None. Copyright © 2013 Elsevier Ltd. All rights reserved.

Aging, Diabetes, and the Public Health System in the United States

PubMed Central

Thomas, G. Darlene; Boseman, Letia A.; Beckles, Gloria L. A.; Albright, Ann L.

2012-01-01

Diabetes (diagnosed or undiagnosed) affects 10.9 million US adults aged 65 years and older. Almost 8 in 10 have some form of dysglycemia, according to tests for fasting glucose or hemoglobin A1c. Among this age group, diagnosed diabetes is projected to reach 26.7 million by 2050, or 55% of all diabetes cases. In 2007, older adults accounted for $64.8 billion (56%) of direct diabetes medical costs, $41.1 billion for institutional care alone. Complications, comorbid conditions, and geriatric syndromes affect diabetes care, and medical guidelines for treating older adults with diabetes are limited. Broad public health programs help, but effective, targeted interventions and expanded surveillance and research and better policies are needed to address the rapidly growing diabetes burden among older adults. PMID:22698044

Therapeutic potential of chalcones as cardiovascular agents.

PubMed

Mahapatra, Debarshi Kar; Bharti, Sanjay Kumar

2016-03-01

Cardiovascular diseases are the leading cause of death affecting 17.3 million people across the globe and are estimated to affect 23.3 million people by year 2030. In recent years, about 7.3 million people died due to coronary heart disease, 9.4 million deaths due to high blood pressure and 6.2 million due to stroke, where obesity and atherosclerotic progression remain the chief pathological factors. The search for newer and better cardiovascular agents is the foremost need to manage cardiac patient population across the world. Several natural and (semi) synthetic chalcones deserve the credit of being potential candidates to inhibit various cardiovascular, hematological and anti-obesity targets like angiotensin converting enzyme (ACE), cholesteryl ester transfer protein (CETP), diacylglycerol acyltransferase (DGAT), acyl-coenzyme A: cholesterol acyltransferase (ACAT), pancreatic lipase (PL), lipoprotein lipase (LPL), calcium (Ca(2+))/potassium (K(+)) channel, COX-1, TXA2 and TXB2. In this review, a comprehensive study of chalcones, their therapeutic targets, structure activity relationships (SARs), mechanisms of actions (MOAs) have been discussed. Chemically diverse chalcone scaffolds, their derivatives including structural manipulation of both aryl rings, replacement with heteroaryl scaffold(s) and hybridization through conjugation with other pharmacologically active scaffold have been highlighted. Chalcones which showed promising activity and have a well-defined MOAs, SARs must be considered as prototype for the design and development of potential anti-hypertensive, anti-anginal, anti-arrhythmic and cardioprotective agents. With the knowledge of these molecular targets, structural insights and SARs, this review may be helpful for (medicinal) chemists to design more potent, safe, selective and cost effective chalcone derivatives as potential cardiovascular agents. Copyright © 2016 Elsevier Inc. All rights reserved.

Effects of Affordable Care Act Marketplaces and Medicaid Eligibility Expansion on Access to Cancer Care.

PubMed

Graves, John A; Swartz, Katherine

The aim of this study was to inform oncologists about how repealing the Affordable Care Act (ACA) may affect their ability to provide cancer therapies for people with cancer enrolled in ACA health plans and why proposals to change Medicaid funding may make it even more difficult for Medicaid beneficiaries to access cancer treatments. We examined the regulations and provisions of the ACA related to how health insurance impacts access to diagnostic testing and treatments for people with cancer, including access to clinical trials. Similarly, we examined federal and state rules affecting Medicaid beneficiaries' access to cancer treatments. Repealing various provisions of the ACA will restrict who has access to both current and new cancer treatments. Such changes also will impact oncology research that depends on having heterogeneous people in clinical trials. Significant changes to the ACA will affect oncology treatment choices of everyone with health insurance-not only the 10 million people newly covered by ACA health plans and the 70 million people with Medicaid coverage.

Effects of Affordable Care Act Marketplaces and Medicaid Eligibility Expansion on Access to Cancer Care

PubMed Central

Graves, John A.; Swartz, Katherine

2017-01-01

Purpose To inform oncologists about how repealing the ACA may affect their ability to provide cancer therapies for people with cancer enrolled in ACA health plans, and why proposals to change Medicaid funding may make it even more difficult for Medicaid beneficiaries to access cancer treatments. Methods We examined the regulations and provisions of the ACA related to how health insurance impacts access to diagnostic testing and treatments for people with cancer, including access to clinical trials. Similarly, we examined federal and state rules affecting Medicaid beneficiaries’ access to cancer treatments. Results Repealing various provisions of the ACA will restrict who has access to both current and new cancer treatments. Such changes also will impact oncology research that depends on having heterogeneous people in clinical trials. Discussion Significant changes to the ACA will affect oncology treatment choices of everyone with health insurance – not just the 10 million people newly covered by ACA health plans and the 70 million people with Medicaid coverage. PMID:28537962

The long-term carbon cycle, fossil fuels and atmospheric composition.

PubMed

Berner, Robert A

2003-11-20

The long-term carbon cycle operates over millions of years and involves the exchange of carbon between rocks and the Earth's surface. There are many complex feedback pathways between carbon burial, nutrient cycling, atmospheric carbon dioxide and oxygen, and climate. New calculations of carbon fluxes during the Phanerozoic eon (the past 550 million years) illustrate how the long-term carbon cycle has affected the burial of organic matter and fossil-fuel formation, as well as the evolution of atmospheric composition.

Challenges and perspectives of Chagas disease: a review

PubMed Central

2013-01-01

Chagas disease (CD), also known as American trypanosomiasis, is caused by the flagellated protozoan Trypanosoma cruzi, and affects an estimated 8 to 10 million people worldwide. In Latin America, 25 million people live in risk areas, while in 2008 alone, 10,000 CD-related deaths were reported. This review aimed to evaluate the challenges of CD control, future perspectives, and actions performed worldwide to control expansion of the disease and its impact on public health in Latin America. PMID:24354455

Tuberculosis--triumph and tragedy.

PubMed

Singh, M M

2003-03-01

Tuberculosis has been making havoc worldwide with an 11.9 million cases to be involved by the year 2005. In India, about 2 million cases are infected every year. Regarding triumphs and tragedies in the control of tuberculosis some points as follows are discussed. (1) Tuberculosis Control Programmes from National Tuberculosis Programme (NTP) to Revised National Tuberculosis Control Programme (RNTCP) and Directly Observed Treatment, Short course (DOTS). (2) Problem of multidrug resistance (MDR) tuberculosis and (3) HIV and tuberculosis. DOTS being largely based on Indian research. It is now being applied worldwide. MDR is strictly a man made problem. Poor prescriptions, poor case management, lack of coordinated education and haphazard treatment research result in drug resistance. Treatment of MDR is difficult. The drug acceptability, tolerance and toxicity have to be considered. HIV and tuberculosis form a deadly duo. They mean more cases, more costs and more national losses.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Diwan, R.

India is generally known as a poor, overpopulated, and underdeveloped country. Its per capita income, even in 1976-77, is less than 100 U.S. dollars. In the 1971 census India's population was estimated at 550 million, or approximately 15% of the world population. It is projected that the 1976 Indian population is close to 600 million. Its government has been making major efforts attacking the problem of underdevelopment; in these efforts it is assumed that once the country is developed, the twin problems of poverty and overpopulation also will be solved. To remove underdevelopment, India has instituted the mechanism of five-yearmore » plans which are an attempt in generating a development process. In this paper the energy implications of this development process are analyzed during the last decade of 1960-1970. Even though changes have taken place in the years 1970-1976, they are not fundamentally or structurally different from the trends established in the ten-year span under study.« less

The value of volume and growth measurements in timber sales management of the National Forests

NASA Technical Reports Server (NTRS)

Lietzke, K. R.

1977-01-01

This paper summarizes work performed in the estimation of gross social value of timber volume and growth rate information used in making regional harvest decisions in the National Forest System. A model was developed to permit parametric analysis. The problem is formulated as one of finding optimal inventory holding patterns. Public timber management differs from other inventory holding problems in that the inventory, itself, generates value over time in providing recreational, aesthetic and environmental goods. 'Nontimber' demand estimates are inferred from past Forest Service harvest and sales levels. The solution requires a description of the harvest rates which maintain the optimum inventory level. Gross benefits of the Landsat systems are estimated by comparison with Forest Service information gathering models. Gross annual benefits are estimated to be $5.9 million for the MSS system and $7.2 million for the TM system.

Control of foot-and-mouth disease by using replication-defective human adenoviruses to deliver vaccines and biotherapeutics

USDA-ARS?s Scientific Manuscript database

Foot-and-mouth disease (FMD) is one of the most contagious viral diseases that can affect cloven-hoofed livestock and wild animals. Outbreaks of FMD have caused devastating economic losses and the slaughter of millions of animals in many regions of the world affecting the food chain and global devel...

Biomedical Risk, Psychosocial Influences, and Developmental Outcomes: Lessons from the Pediatric HIV Population in Africa

ERIC Educational Resources Information Center

Serpell, Robert; Marfo, Kofi; Abubakar, Amina

2014-01-01

Sub-Saharan Africa is home to millions of HIV-affected children. These children are likely to experience multiple developmental delays. In this chapter, I present data highlighting compromised neurobehavioral, mental health, and scholastic outcomes for children affected by HIV. Furthermore, I discuss biomedical factors (e.g., disease severity and…

Endometriosis (For Teens)

MedlinePlus

... more than 5 million American women, including teen girls, are affected. It's not always diagnosed right away ... severe endometriosis can make it harder for a girl to have children in the future, it's a ...

Pentium Pro inside. 1; A treecode at 430 Gigaflops on ASCI Red

NASA Technical Reports Server (NTRS)

Warren, M. S.; Becker, D. J.; Sterling, T.; Salmon, J. K.; Goda, M. P.

1997-01-01

As an entry for the 1997 Gordon Bell performance prize, we present results from two methods of solving the gravitational N-body problem on the Intel Teraflops system at Sandia National Laboratory (ASCI Red). The first method, an O(N2) algorithm, obtained 635 Gigaflops for a 1 million particle problem on 6800 Pentium Pro processors. The second solution method, a tree-code which scales as O(N log N), sustained 170 Gigaflops over a continuous 9.4 hour period on 4096 processors, integrating the motion of 322 million mutually interacting particles in a cosmology simulation, while saving over 100 Gigabytes of raw data. Additionally, the tree-code sustained 430 Gigaflops on 6800 processors for the first 5 time-steps of that simulation. This tree-code solution is approximately 105 times more efficient than the O(N2) algorithm for this problem. As an entry for the 1997 Gordon Bell price/performance prize, we present two calculations from the disciplines of astrophysics and fluid dynamics. The simulations were performed on two 16 Pentium Pro processor Beowulf-class computers (Loki and Hyglac) constructed entirely from commodity personal computer technology, at a cost of roughly $50k each in September, 1996. The price of an equivalent system in August 1997 is less than $30. At Los Alamos, Loki performed a gravitational tree-code N-body simulation of galaxy formation using 9.75 million particles, which sustained an average of 879 Mflops over a ten day period, and produced roughly 10 Gbytes of raw data.

Depression FAQs

Cancer.gov

Depression affects about 15 million American adults every year. Women are more likely to get depression than men. In general, about one out of every four women will get depression at some point in her life.

77 FR 15592 - Privacy Act; Implementation

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-16

... million or more or adversely affect in a material way the economy; a sector of the economy; productivity... integrity of Federal testing materials; and safeguard evaluation materials used for military promotions when...

Geography of blizzards in the conterminous United States, 1959--2000

NASA Astrophysics Data System (ADS)

Schwartz, Robert Michael

2001-07-01

Many individuals think of tornadoes and hurricanes when considering weather-related storms. However, winter storms and blizzards have potential impacts on millions of people and effects on the social landscape such as fatalities, injuries, and economic consequences. Additionally, these storms can last from a few hours to over a week. This study established a climatology of blizzards in the conterminous United States from 1959-2000 utilizing data from Storm Data to identify the spatial and temporal patterns of blizzards. The annual probability of a blizzard on a county level was calculated to give the empirical probability of having a blizzard in any given winter season. Additionally, the number of blizzards were compared to the El Nino Southern Oscillation (ENSO) teleconnection by running a linear regression to check for correlation. Finally, the social impacts of blizzards studied included the population affected, fatalities, injuries, property damage, crop damage, and federal disaster declarations. Maps were produced utilizing MapInfo and ArcView Geographic Information Systems (GIS) to summarize regional differences and temporal trends. There were 438 blizzards analyzed in the study with an annual mean of 10.7 blizzards per winter season with the majority of storms occurring in the northern Plains states of North Dakota, South Dakota, and western Minnesota. Time series analysis indicated an increase in the number of blizzards over the 41-year period while there was no linear trend of the area affected by blizzards. Annual probabilities of a blizzard were as high as 76% for Cavalier, Rolette, Steele, Towner, and Traill Counties in North Dakota. The ENSO teleconnection and the number of blizzards on the national scale suggested a negative correlation with fewer blizzards during El Nino episodes. Social impacts indicated blizzards affected 26.3 million per season with 16 fatalities and 49 injuries per season reported to Storm Data . The total population affected each winter did not show a linear trend. An average winter reported 551 million in property damage and 26 million in crop damage according to Storm Data. The number of declared disasters or emergencies due to blizzards has been increasing, especially in the 1990s.

New NIH Director Dr. Francis Collins on Medical Research That Benefits Everyone's Health

MedlinePlus

... improve outcomes. For instance, in the area of comparative effectiveness, NIH has been studying various clinical problems ... we have been given another $400 million for comparative effectiveness research. What impact will this have, do ...

Science on Sequoia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bertsch, Adam; Draeger, Erik; Richards, David

2017-01-12

With Sequoia at Lawrence Livermore National Laboratory, researchers explore grand challenging problems and are generating results at scales never before achieved. Sequoia is the first computer to have more than one million processors and is one of the fastest supercomputers in the world.

The Decline of American Education

ERIC Educational Resources Information Center

Cooper, Stirling M.

1971-01-01

This report, applicable to all American cities, demonstrates how an environment has been created in the Nation's schools that is hostile to education, and that it is time to seek alternatives to additional millions of dollars to solve people problems. (Author)

Intelligent transportation systems field operational test cross-cutting study : advanced traveler information systems

DOT National Transportation Integrated Search

1998-09-01

Approximately 2 million roadside inspections of commercial motor vehicles (CMVs) are conducted annually, primarily through the joint Federal and State Motor Carrier Safety Assistance Program (MCSAP). Vehicles and drivers with serious safety problems ...

Advances in wind erosion modelling in Europe

NASA Astrophysics Data System (ADS)

Borrelli, Pasquale; Lugato, Emanuele; Alewell, Christine; Montanarella, Luca; Panagos, Panos

2017-04-01

Soil erosion by wind is a serious environmental problem often resulting in severe forms of soil degradation. Wind erosion is also a phenomenon relevant for Europe, although this land degradation process has been overlooked until very recently. The state-of-the-art literature presents wind erosion as a process that locally affects the semi-arid areas of the Mediterranean region as well as the temperate climate areas of the northern European countries. Actual observations, field measurements and modelling assessments, however, are all extremely limited and highly unequally distributed across Europe. As a result, we currently lack comprehensive understanding about where and when wind erosion occurs in Europe, and the intensity of erosion that poses a threat to agricultural productivity. Today's challenge is to integrate the insights of local experiments and field-scale models into a new generation of large-scale wind erosion models. While naturally being less accurate than field-scale models, these large-scale modelling approaches still provide essential knowledge about where and when wind erosion occurs and can disclose the level of risk for agricultural productivity in specific areas. Here, we present a geographic information system (GIS) version of the RWEQ (named GIS-RWEQ) to quantitatively assess soil loss by wind over large study areas (Land Degradation & Development, DOI: 10.1002/ldr.2588). The model designed to predict the daily soil loss potential at a ca. 1 km2 spatial resolution shows high consistency with local measurements reported in literature. The average soil loss predicted by GIS-RWEQ for the European arable land totals 62 million Mg yr-1, with an average area-specific soil loss of 0.53 Mg yr-1. The JRC model RUSLE2015, for the same area estimates 295 million Mg yr-1 of soil loss due to water erosion. Notably, soil loss by wind erosion in the European arable land could be as high as 20% of water erosion, even though the areas affected are mainly concentrated in hotspots.

Trends in health care expenditures, utilization, and health status among US adults with spine problems, 1997-2006.

PubMed

Martin, Brook I; Turner, Judith A; Mirza, Sohail K; Lee, Michael J; Comstock, Bryan A; Deyo, Richard A

2009-09-01

Analysis of nationally representative survey data for spine-related health care expenditures, utilization and self-reported health status. To study trends from 1997 to 2006 in per-user expenditures for spine-related inpatient, outpatient, pharmacy, and emergency services; and to compare these trends to changes in health status. Although prior work has shown overall spine-related expenditures accounted for $86 billion in 2005, increasing 65% since 1997, the study did not report per-user expenditures. Understanding population-level per-user expenditure for specific services relative to changes in the health status may help assess the value of these services. We analyzed data from the Medical Expenditure Panel Survey, a multistage survey sample designed to produce unbiased national estimates of health care utilization and expenditure. Spine-related hospitalizations, outpatient visits, prescription medications and emergency department visits were identified using ICD-9-CM diagnosis codes. Regression analyses controlling for age, sex, comorbidity, and time (years) were used to examine trends from 1997 to 2006 in inflation-adjusted per-user expenditures, and utilization, and self-reported health status. An average of 1774 respondents with spine problems was surveyed per year; the proportion suggested an increase in the number of people who sought treatment for spine problems in the United States from 14.8 million in 1997 to 21.9 million in 2006. From 1997 to 2006, the mean adjusted per-user expenditures were the largest component of increasing total costs for inpatient hospitalizations, prescription medications, andemergency department visits, increasing 37% (from $13,040 in 1997 to $17,909 in 2006), 139% (from $166 to $397), and 84% (from $81 to $149), respectively. A 49% increase in the number of patients seeking spine-related care (from 12.2 million in 1997 to 18.2 million in 2006) was the largest contributing factor to increased outpatient expenditures. Population measures of mental health and work, social, and physical limitations worsened over time among people with spine problems. Expenditure increases for spine-related inpatient, prescription, and emergency services were primarily the result of increasing per-user expenditures, while those related to outpatient visits were primarily due to an increase in the number of users of ambulatory services.

Economic costs of depression in China.

PubMed

Hu, Teh-wei; He, Yanling; Zhang, Mingyuan; Chen, Ningshan

2007-02-01

A recent survey in China indicated the 12-month prevalence rate of depressive disorders was 2.5% in Beijing and 1.7% in Shanghai. These disorders may result in disability, premature death, and severe suffering of those affected and their families. This study estimates the economic consequences of depressive disorders in China. Depressive disorders can have both direct and indirect costs. To obtain direct costs, the research team interviewed 505 patients with depressive disorders and their caregivers in eight clinics/hospitals in five cities in China. Depression-related suicide rates were obtained from published literature. The human capital approach was used to estimate indirect costs. Epidemiological data were taken from available literature. The total estimated cost of depression in China is 51,370 million Renminbi (RMB) (or US $6,264 million) at 2002 prices. Direct costs were 8,090 million RMB (or US$ 986 million), about 16% of the total cost of depression. Indirect costs were 43,280 million RMB (or US$ 5,278 million), about 84% of the total cost of depression. Depression is a very costly disorder in China. The application of an effective treatment--reducing the length of depressive episodes (or preventing episodes) and reducing suicide rates--will lead to a significant reduction in the total burden resulting from depressive disorders. Government policymakers should seriously consider further investments in mental health services.

Sleeping with technology: cognitive, affective, and technology usage predictors of sleep problems among college students.

PubMed

Rosen, Larry; Carrier, Louis M; Miller, Aimee; Rokkum, Jeffrey; Ruiz, Abraham

2016-03-01

Sleep problems related to technology affect college students through several potential mechanisms including displacement of sleep due to technology use, executive functioning abilities, and the impact of emotional states related to stress and anxiety about technology availability. In the present study, cognitive and affective factors that influence technology usage were examined for their impact upon sleep problems. More than 700 US college students completed an online questionnaire addressing technology usage, anxiety/dependence, executive functioning, nighttime phone usage, bedtime phone location, and sleep problems. A path model controlling for background variables was tested using the data. The results showed that executive dysfunction directly predicted sleep problems as well as affected sleep problems through nighttime awakenings. In addition, anxiety/dependence increased daily smartphone usage and also increased nighttime awakenings, which, in turn, affected sleep problems. Thus, both the affective and cognitive factors that influence technology usage affected sleep problems. Copyright © 2016 National Sleep Foundation. Published by Elsevier Inc. All rights reserved.

Hunger influenced life expectancy in war-torn Sub-Saharan African countries.

PubMed

Uchendu, Florence N

2018-04-27

Malnutrition is a global public health problem especially in developing countries experiencing war/conflicts. War might be one of the socio-political factors influencing malnutrition in Sub-Saharan African (SSA) countries. This study aims at determining the influence of war on corruption, population (POP), number of population malnourished (NPU), food security and life expectancy (LE) in war-torn SSA countries (WTSSA) by comparing their malnutrition indicators. Fourteen countries in WTSSA were stratified into zones according to war incidences. Countries' secondary data on population (POP), NPU, Food Security Index (FSI), corruption perceptions index (CPI), Global Hunger Index (GHI) and LE were obtained from global published data. T test, multivariate and Pearson correlation analyses were performed to determine the relationship between CPI, POP, GHI, FSI, NPU, male LE (MLE) and female LE (FLE) in WTSSA at p < .05. Data were presented in tables, means, standard deviation and percentages. Mean NPU, CPI, GHI, POP, FSI, MLE and FLE in WTSSA were 5.0 million, 28.3%, 18.2%, 33.8 million, 30.8%, 54.7 years and 57.1 years, respectively. GHI significantly influenced LE in both male and female POP in WTSSA. NPU, CPI, FSI, GHI and FLE were not significantly different according to zones except in MLE. Malnutrition indicators were similarly affected in WTSSA. Hunger influenced life expectancy. Policies promoting good governance, equity, peaceful co-existence, respect for human right and adequate food supply will aid malnutrition eradication and prevent war occurrences in Sub-Saharan African countries.

The link between poverty, environment and development. The political challenge of localizing Agenda 21.

PubMed

Wichmann, R

1995-11-01

This article discusses the links between poverty, development, the environment, and implementing Agenda 21. The poor in large cities experience greater health risks and threats from environmental hazards. The poor also face inadequate housing, poor sanitation, polluted drinking water, and lack of other basic services. Many poor live in marginalized areas more susceptible to environmental degradation. During 1990-2030, population size may reach 9.7 billion, or 3.7 billion more than today. 90% may be urban residents. Already a large proportion of urban population live in a decaying urban environment with health and life threatening conditions. At least 250 million do not have easy access to safe piped water. 400 million lack proper sanitation. The liberalization of the global economy is fueling urbanization. The cycle of poverty and environmental decline requires rapid economic growth and closing of the infrastructure gaps. Policy initiatives of Agenda 21 occur at the local urban level. At this level, policies directly affect people. The future success of Agenda 21 will depend on local initiatives. Management approaches may need to change in order to achieve sustainable development. The poor will be more vocal and heard from in the future. Critical areas of management include waste management, pollution control, traffic, transportation, energy, economic development, and job creation. Society must be able to participate in setting priorities. About 1500 local authorities are involved in Agenda 21 planning initiatives. Curitiba, Brazil, is an example of how cities can solve community problems.

The Association between Motivation, Affect, and Self-regulated Learning When Solving Problems.

PubMed

Baars, Martine; Wijnia, Lisette; Paas, Fred

2017-01-01

Self-regulated learning (SRL) skills are essential for learning during school years, particularly in complex problem-solving domains, such as biology and math. Although a lot of studies have focused on the cognitive resources that are needed for learning to solve problems in a self-regulated way, affective and motivational resources have received much less research attention. The current study investigated the relation between affect (i.e., Positive Affect and Negative Affect Scale), motivation (i.e., autonomous and controlled motivation), mental effort, SRL skills, and problem-solving performance when learning to solve biology problems in a self-regulated online learning environment. In the learning phase, secondary education students studied video-modeling examples of how to solve hereditary problems, solved hereditary problems which they chose themselves from a set of problems with different complexity levels (i.e., five levels). In the posttest, students solved hereditary problems, self-assessed their performance, and chose a next problem from the set of problems but did not solve these problems. The results from this study showed that negative affect, inaccurate self-assessments during the posttest, and higher perceptions of mental effort during the posttest were negatively associated with problem-solving performance after learning in a self-regulated way.

An experience sampling study of learning, affect, and the demands control support model.

PubMed

Daniels, Kevin; Boocock, Grahame; Glover, Jane; Holland, Julie; Hartley, Ruth

2009-07-01

The demands control support model (R. A. Karasek & T. Theorell, 1990) indicates that job control and social support enable workers to engage in problem solving. In turn, problem solving is thought to influence learning and well-being (e.g., anxious affect, activated pleasant affect). Two samples (N = 78, N = 106) provided data up to 4 times per day for up to 5 working days. The extent to which job control was used for problem solving was assessed by measuring the extent to which participants changed aspects of their work activities to solve problems. The extent to which social support was used to solve problems was assessed by measuring the extent to which participants discussed problems to solve problems. Learning mediated the relationship between changing aspects of work activities to solve problems and activated pleasant affect. Learning also mediated the relationship between discussing problems to solve problems and activated pleasant affect. The findings indicated that how individuals use control and support to respond to problem-solving demands is associated with organizational and individual phenomena, such as learning and affective well-being.

Positive affect: phenotypic and etiologic associations with prosocial behaviors and internalizing problems in toddlers

PubMed Central

Wang, Manjie; Saudino, Kimberly J.

2015-01-01

Despite evidence for the associations of positive affect to prosocial behaviors and internalizing problems, relatively little is known about the underlying etiology. The sample comprised over 300 twin pairs at age 3. Positive affect, prosocial behaviors, and internalizing problems were assessed using the Toddler Behavior Assessment Questionnaire (Goldsmith, 1996), the Revised Rutter Parent Scale for Preschool Children (Hogg et al., 1997), and the Child Behavior Checklist for ages 1.5–5 (Achenbach, 1991), respectively. Positive affect correlated positively with prosocial behaviors, and negatively with internalizing problems. Prosocial behaviors were negatively associated with internalizing problems. The relations of positive affect to prosocial behaviors and internalizing problems were due to environmental effects (shared and non-shared). In contrast, the link between prosocial behaviors and internalizing problems was entirely explained by genetic effects. The current study has moved beyond prior emphasis on negative affect and elucidated the less understood etiology underlying the associations between positive affect, prosocial behaviors, and internalizing problems. This study could guide the development of programs for promoting prosocial behaviors and alleviating internalizing problems in children. PMID:25914668

Positive affect: phenotypic and etiologic associations with prosocial behaviors and internalizing problems in toddlers.

PubMed

Wang, Manjie; Saudino, Kimberly J

2015-01-01

Despite evidence for the associations of positive affect to prosocial behaviors and internalizing problems, relatively little is known about the underlying etiology. The sample comprised over 300 twin pairs at age 3. Positive affect, prosocial behaviors, and internalizing problems were assessed using the Toddler Behavior Assessment Questionnaire (Goldsmith, 1996), the Revised Rutter Parent Scale for Preschool Children (Hogg et al., 1997), and the Child Behavior Checklist for ages 1.5-5 (Achenbach, 1991), respectively. Positive affect correlated positively with prosocial behaviors, and negatively with internalizing problems. Prosocial behaviors were negatively associated with internalizing problems. The relations of positive affect to prosocial behaviors and internalizing problems were due to environmental effects (shared and non-shared). In contrast, the link between prosocial behaviors and internalizing problems was entirely explained by genetic effects. The current study has moved beyond prior emphasis on negative affect and elucidated the less understood etiology underlying the associations between positive affect, prosocial behaviors, and internalizing problems. This study could guide the development of programs for promoting prosocial behaviors and alleviating internalizing problems in children.

Safe application of regionalization for trade in poultry and poultry products during highly pathogenic avian influenza outbreaks in the USA.

PubMed

Swayne, David E; Hill, Rick E; Clifford, John

2017-04-01

The 2014-2015 H5Nx high pathogenicity avian influenza (HPAI) outbreak affected 211 commercial premises, 21 backyard flocks, 75 individual wild birds and four captive-reared raptors in 21 Western and upper Midwestern states, resulting in death or culling of over 50.4 million poultry in the stamping-out programme that cost the US government $850 million. The outbreak had a negative $3.3 billion impact on the economy. Seventeen trading partners suspended imports of all US-origin poultry and poultry products while 38 trading partners regionalized the United States, and allowed trade in poultry and poultry products to continue from areas of the US not affected by HPAI. Disease response and control activities in addition to the use of comprehensive surveillance and regionalization (zoning) as prescribed by the OIE Terrestrial Animal Health Code are a scientifically valid and effective means to maintain safe trade in poultry and poultry products. This was further realized during the 2016 H7N8 HPAI outbreak in Dubois County, Indiana, with greater acceptance of regionalization and continuity in trade with a more limited cost of $30 million for eradication.

China's battle to save the environment.

PubMed

Nash, N

1989-01-01

By the year 2000 a Great Green Wall of forests may be crossing the country from northwest to northeast, a total of 53 million hectares of green protection from encroaching deserts and erosion, stretching through 12 provinces to increase the nation's forest cover, which now stands at a mere 12.7% of China's territory. Soils have been degraded to a critical level only within the past 150 years. At present, about one-sixth of the total land is affected by erosion. In 1988 more than 11 million hectares of farmland, one-tenth of the total sown acreage, suffered from severe drought. Another 7.5 million hectares of crops were flooded, and grain output has been dropping steadily. China is now importing more than 1 billion tons of food staples to feed its population. In all big cities including the capital Beijing, sulphur dioxide and dust levels in the atmosphere surpass the norm set by the State. The most seriously polluted city in China is Benxi, situated in Liaoning Province, which contains some 420 factories. Shanghai has become a preview of what is in store for many Chinese cities unless urgent anti-pollution measures are designed and implemented. Much of the city's municipal and industrial wastes are simply flushed untreated into rivers and shallow coastal waters. Some 34 billion tons of municipal and industrial wastes are flushed into China's rivers and streams every year. A highly lauded forest farm in Sichuan Province credits afforestation with increased precipitation in the dry season, reduced soil erosion, and a halt to the flooding of some 10 rivers in the region. Many of China's 32,000 species of higher plants are endangered; and similarly, many of the nation's 2200 species of birds and animals, like the giant panda, are threatened with extinction. The country's gigantic population remains the key problem as well as the key to its solution.

Fighting ambient air pollution and its impact on health: from human rights to the right to a clean environment.

PubMed

Guillerm, N; Cesari, G

2015-08-01

Clean air is one of the basic requirements of human health and well-being. However, almost nine out of 10 individuals living in urban areas are affected by air pollution. Populations living in Africa, South-East Asia, and in low- and middle-income countries across all regions are the most exposed. Exposure to outdoor air pollution ranks as the ninth leading risk factor for mortality, killing 3.2 million people each year, especially young children, the elderly, persons with lung or cardiovascular disease, those who work or exercise outdoors and low-income populations. In October 2013, the International Agency for Research on Cancer (IARC) classified outdoor air pollution as carcinogenic to humans, calling air pollution 'a major environmental health problem'. Human rights and environmental norms are powerful tools to combat air pollution and its impact on health. The dependence of human rights on environmental quality has been recognised in international texts and by human rights treaty bodies. The growing awareness of the environment has already yielded considerable legislative and regulatory output. However, the implementation of standards remains a pervasive problem. In the fight against violations of norms, citizens have a crucial role to play. We discuss the relevance of a yet to be proclaimed standalone right to a healthy environment.

Optimizing patient treatment decisions in an era of rapid technological advances: the case of hepatitis C treatment.

PubMed

Liu, Shan; Brandeau, Margaret L; Goldhaber-Fiebert, Jeremy D

2017-03-01

How long should a patient with a treatable chronic disease wait for more effective treatments before accepting the best available treatment? We develop a framework to guide optimal treatment decisions for a deteriorating chronic disease when treatment technologies are improving over time. We formulate an optimal stopping problem using a discrete-time, finite-horizon Markov decision process. The goal is to maximize a patient's quality-adjusted life expectancy. We derive structural properties of the model and analytically solve a three-period treatment decision problem. We illustrate the model with the example of treatment for chronic hepatitis C virus (HCV). Chronic HCV affects 3-4 million Americans and has been historically difficult to treat, but increasingly effective treatments have been commercialized in the past few years. We show that the optimal treatment decision is more likely to be to accept currently available treatment-despite expectations for future treatment improvement-for patients who have high-risk history, who are older, or who have more comorbidities. Insights from this study can guide HCV treatment decisions for individual patients. More broadly, our model can guide treatment decisions for curable chronic diseases by finding the optimal treatment policy for individual patients in a heterogeneous population.

Optimizing Patient Treatment Decisions in an Era of Rapid Technological Advances: The Case of Hepatitis C Treatment

PubMed Central

Liu, Shan; Goldhaber-Fiebert, Jeremy D.; Brandeau, Margaret L.

2015-01-01

How long should a patient with a treatable chronic disease wait for more effective treatments before accepting the best available treatment? We develop a framework to guide optimal treatment decisions for a deteriorating chronic disease when treatment technologies are improving over time. We formulate an optimal stopping problem using a discrete-time, finite-horizon Markov decision process. The goal is to maximize a patient’s quality-adjusted life expectancy. We derive structural properties of the model and analytically solve a three-period treatment decision problem. We illustrate the model with the example of treatment for chronic hepatitis C virus (HCV). Chronic HCV affects 3–4 million Americans and has been historically difficult to treat, but increasingly effective treatments have been commercialized in the past few years. We show that the optimal treatment decision is more likely to be to accept currently available treatment—despite expectations for future treatment improvement—for patients who have high-risk history, who are older, or who have more comorbidities. Insights from this study can guide HCV treatment decisions for individual patients. More broadly, our model can guide treatment decisions for curable chronic diseases by finding the optimal treatment policy for individual patients in a heterogeneous population. PMID:26188961

ACOG Committee Opinion No. 518: Intimate partner violence.

PubMed

2012-02-01

Intimate partner violence (IPV) is a significant yet preventable public health problem that affects millions of women regardless of age, economic status, race, religion, ethnicity, sexual orientation, or educational background. Individuals who are subjected to IPV may have lifelong consequences, including emotional trauma, lasting physical impairment, chronic health problems, and even death. Although women of all ages may experience IPV, it is most prevalent among women of reproductive age and contributes to gynecologic disorders, pregnancy complications, unintended pregnancy, and sexually transmitted infections, including human immunodeficiency virus (HIV). Obstetrician–gynecologists are in a unique position to assess and provide support for women who experience IPV because of the nature of the patient–physician relationship and the many opportunities for intervention that occur during the course of pregnancy, family planning, annual examinations, and other women’s health visits. The U.S. Department of Health and Human Services has recommended that IPV screening and counseling should be a core part of women’s preventive health visits. Physicians should screen all women for IPV at periodic intervals, including during obstetric care (at the first prenatal visit, at least once per trimester, and at the postpartum checkup), offer ongoing support, and review available prevention and referral options. Resources are available in many communities to assist women who experience IPV.

Winning the War: A Historical Analysis of the FFA during World War II

ERIC Educational Resources Information Center

Wolf, Kattlyn J.; Connors, James J.

2009-01-01

The United States' participation in World War II affected millions of men, women, and children, both at home and around the world. The war effort also affected the Future Farmers of America (FFA). FFA members, agriculture teachers, and national FFA officers all volunteered to serve their country during the war. Local FFA chapters and individual…

Sub-Saharan Africa Report No. 2807.

DTIC Science & Technology

1983-06-08

USSR Journalists’ Agreement Afghan Revolution Supported GDR Farmers’ Agreement GABON Observers Reportedly Consider Bongo Firmly in...is the position of white workers in South Africa? To what extent have pri- vileges affected their attitudes?" "What is your definition of the...reconversion of huge military expenditure into sound develop- ment programmes to alleviate poverty, illiteracy, disease and hunger which affect millions of

Don't Panic! | NIH MedlinePlus the Magazine

MedlinePlus

... please turn Javascript on. Feature: Phobias and Anxiety Disorders Don't Panic! Past Issues / Fall 2010 Table of Contents Phobias and other anxiety disorders affect millions of Americans. But researchers have found ...

A global assessment of closed forests, deforestation and malaria risk

PubMed Central

GUERRA, C. A.; SNOW, R. W.; HAY, S. I.

2011-01-01

Global environmental change is expected to affect profoundly the transmission of the parasites that cause human malaria. Amongst the anthropogenic drivers of change, deforestation is arguably the most conspicuous, and its rate is projected to increase in the coming decades. The canonical epidemiological understanding is that deforestation increases malaria risk in Africa and the Americas and diminishes it in South–east Asia. Partial support for this position is provided here, through a systematic review of the published literature on deforestation, malaria and the relevant vector bionomics. By using recently updated boundaries for the spatial limits of malaria and remotely-sensed estimates of tree cover, it has been possible to determine the population at risk of malaria in closed forest, at least for those malaria-endemic countries that lie within the main blocks of tropical forest. Closed forests within areas of malaria risk cover approximately 1.5 million km2 in the Amazon region, 1.4 million km2 in Central Africa, 1.2 million km2 in the Western Pacific, and 0.7 million km2 in South–east Asia. The corresponding human populations at risk of malaria within these forests total 11.7 million, 18.7 million, 35.1 million and 70.1 million, respectively. By coupling these numbers with the country-specific rates of deforestation, it has been possible to rank malaria-endemic countries according to their potential for change in the population at risk of malaria, as the result of deforestation. The on-going research aimed at evaluating these relationships more quantitatively, through the Malaria Atlas Project (MAP), is highlighted. PMID:16630376

Recent Rates of Forest Harvest and Conversion in North America

NASA Technical Reports Server (NTRS)

Masek, Jeffrey G.; Cohen, Warren B.; Leckie, Donald; Wulder, Michael A.; Vargas, Rodrigo; de Jong, Ben; Healey, Sean; Law, Beverly; Birdsey, Richard; Houghton, R. A.;

Natural gas use is taking off

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kauffmann, B.G.

1995-07-01

The paper describes an infrared radiant heat process to de-ice aircraft. A typical 727 aircraft de-icing costs $2000--3000 using the current glycol method. The natural gas powered heater would only cost $400 per aircraft and would not pose the environmental problems that the glycol does. It is estimated that one Infratek system could consume 3.8 million cubic feet of natural gas each year during the de-icing season. Large airports might have as many as 10 units. 3.8 million cu. ft. of gas is equal to about 40 New York residential customers or eight New York commercial customers.

New challenges in studying nutrition-disease interactions in the developing world

PubMed Central

Prentice, Andrew M.; Gershwin, M. Eric; Schaible, Ulrich E.; Keusch, Gerald T.; Victora, Cesar G.; Gordon, Jeffrey I.

2008-01-01

Latest estimates indicate that nutritional deficiencies account for 3 million child deaths each year in less-developed countries. Targeted nutritional interventions could therefore save millions of lives. However, such interventions require careful optimization to maximize benefit and avoid harm. Progress toward designing effective life-saving interventions is currently hampered by some serious gaps in our understanding of nutrient metabolism in humans. In this Personal Perspective, we highlight some of these gaps and make some proposals as to how improved research methods and technologies can be brought to bear on the problems of undernourished children in the developing world. PMID:18382744

Health economics of weight management: evidence and cost.

PubMed

Kouris-Blazos, Antigone; Wahlqvist, Mark L

2007-01-01

The World Health Organization estimates that around one billion people throughout the world are overweight and that over 300 million of these are obese and if current trends continue, the number of overweight persons will increase to 1.5 billion by 2015. The number of obese adults in Australia is estimated to have risen from 2.0 million in 1992/93 to 3.1 million in 2005. The prevalence of obesity has been increasing due to a convergence of factors--the rise of TV viewing, our preference for takeaway and pre-prepared foods, the trend towards more computer-bound sedentary jobs, and fewer opportunities for sport and physical exercise. Obesity is not only linked to lack of self esteem, social and work discrimination, but also to illnesses such as the metabolic syndrome and hyperinsulinaemia (which increases the risk of developing heart disease, diabetes, hypertension, fatty liver), cancer, asthma, dementia, arthritis and kidney disease. It has been estimated that the cost of obesity in Australia in 2005 was $1,721 million. Of this amount, $1,084 million were direct health costs, and $637 million indirect health costs (due to lost work productivity, absenteeism and unemployment). The prevalence cost per year for each obese adult has been estimated at $554 and the value of an obesity cure is about $6,903 per obese person. Government efforts at reducing the burden remain inadequate and a more radical approach is needed. The Australian government, for example, has made changes to Medicare so that GPs can refer people with chronic illness due to obesity to an exercise physiologist and dietitian and receive a Medicare rebate, but so far these measures are having no perceptible effect on obesity levels. There is a growing recognition that both Public Health and Clinical approaches, and Private and Public resources, need to be brought to this growing problem. Australian health economist, Paul Gross, from the Institute of Health Economics and Technology Assessment claims there is too much reliance on health workers to treat the problem, especially doctors, who have not been given additional resources to manage obesity outside a typical doctor's consultation. Gross has recommended that further changes should be made to Medicare, private health insurance, and workplace and tax legislation to give people financial incentives to change their behaviour because obesity should not just be treated by governments as a public health problem but also as a barrier to productivity and a drain on resources. A Special Report of the WMCACA (Weight Management Code Administration Council of Australia) (www.weightcouncil.org) on the "Health Economics of Weight Management" has been published in the Asia Pacific Journal of Clinical Nutrition in September 2006. This report explores the cost benefit analysis of weight management in greater detail.

National and subnational prevalence and burden of glaucoma in China: A systematic analysis

PubMed Central

Song, Peige; Wang, Jiawen; Bucan, Kajo; Theodoratou, Evropi; Rudan, Igor; Chan, Kit Yee

2017-01-01

Background Glaucoma, the second leading cause of blindness, affects approximately 64.3 million individuals worldwide. In China, demographic ageing is in rapid progress. Yet detailed and up–to–date estimates of the scale of glaucoma are rare. We aimed to quantify and understand the prevalence and burden of glaucoma in China from 1990 to 2015, with projections until 2050. Methods For this systematic review and meta–analysis, we searched China National Knowledge Infrastructure (CNKI), Wanfang, Chinese Biomedicine Literature Database (CBM–SinoMed), PubMed, Embase and Medline using comprehensive search strategies to identify all relevant articles that have reported the prevalence of glaucoma in the general Chinese population. We used a multilevel mixed–effect meta–regression to estimate the prevalence rates of primary open–angle glaucoma (POAG) and primary angle–closure glaucoma (PACG), and a random–effects meta–analysis to pool the overall prevalence of secondary glaucoma. United Nations population data were used to estimate and project the number of people with glaucoma from 1990 to 2050. Univariable and multivariable meta–regressions were conducted to assess the association between the prevalence of POAG and PACG and relevant demographic and geographic factors. The national burden of POAG and PACG in the years 2000 and 2010 were distributed to six geographic regions accordingly. Results From 1990 to 2015, the prevalence of all glaucoma ranged from 2.59% (95% CI = 1.96–3.49) to 2.58% (95% CI = 1.94–3.47). For different subtypes of glaucoma, the overall prevalence of POAG ranged from 1.03% (95% CI = 0.67–1.58) in 1990 to 1.02% (95% CI = 0.67–1.57) in 2015, PACG from 1.41% (95% CI = 1.18–1.68) to 1.40% (95% CI = 1.17–1.68). The overall prevalence of secondary glaucoma was 0.15% (95% CI = 0.10–0.23) during this period. The number of people with all glaucoma in China was 5.92 million (95% CI = 4.47–7.97) in 1990, and 13.12 million (95% CI = 9.88–17.68) in 2015. This increasing trend was also witnessed in different subtypes of glaucoma. The number of people affected by POAG increased from 2.35 million (95% CI = 1.54–3.60) in 1990 to 5.22 million (95% CI = 3.40–7.98) in 2015, PACG from 3.22 million (95% CI = 2.70–3.84) to 7.14 million (95% CI = 5.97–8.53), and secondary glaucoma from 0.34 million (95% CI = 0.23–0.53) to 0.76 million (95% CI = 0.51–1.17). In 2015, more than half (54.42%) of the glaucoma cases were PACG, followed by POAG (39.79%) and secondary glaucoma (5.79%). By 2050, the number of all glaucoma cases in China will be 25.16 million (95% CI = 18.96–33.86). In the multivariable meta–regressions, the odds ratio (OR) for each decade’s increase in age was 1.43 (95% CI = 1.33–1.55) for POAG, and 1.65 (95% CI = 1.51–1.80) for PACG; males were more likely to have POAG (OR 1.36, 95% CI = 1.17–1.59), but less likely to have PACG (OR 0.53, 95% CI = 0.46–0.60) compared with females. After adjustment of age and gender, people living in urban areas were more likely to have POAG compared with those in rural areas (OR 1.54, 95% CI = 1.02–2.35). People in Northeast China were at a higher risk (OR 1.77, 95% CI = 1.07–2.94) of having PACG than people in East China. Among the six regions, East China owed the most POAG and PACG cases, whereas Northwest China owed the least. Conclusions This systematic review and meta–analysis suggests a substantial burden of glaucoma in China, with great variances among the different age groups, genders, settings and geographic regions. With the dramatic ageing trend in the next three decades, the prevalence and burden of glaucoma will continue to increase. More elaborate epidemiological studies are needed to optimise public health strategies for mitigating this important health problem. PMID:29302324

Impacts of physical and chemical aquifer heterogeneity on basin-scale solute transport: Vulnerability of deep groundwater to arsenic contamination in Bangladesh

NASA Astrophysics Data System (ADS)

Michael, Holly A.; Khan, Mahfuzur R.

2016-12-01

Aquifer heterogeneity presents a primary challenge in predicting the movement of solutes in groundwater systems. The problem is particularly difficult on very large scales, across which permeability, chemical properties, and pumping rates may vary by many orders of magnitude and data are often sparse. An example is the fluvio-deltaic aquifer system of Bangladesh, where naturally-occurring arsenic (As) exists over tens of thousands of square kilometers in shallow groundwater. Millions of people in As-affected regions rely on deep (≥150 m) groundwater as a safe source of drinking water. The sustainability of this resource has been evaluated with models using effective properties appropriate for a basin-scale contamination problem, but the extent to which preferential flow affects the timescale of downward migration of As-contaminated shallow groundwater is unknown. Here we embed detailed, heterogeneous representations of hydraulic conductivity (K), pumping rates, and sorptive properties (Kd) within a basin-scale numerical groundwater flow and solute transport model to evaluate their effects on vulnerability and deviations from simulations with homogeneous representations in two areas with different flow systems. Advective particle tracking shows that heterogeneity in K does not affect average travel times from shallow zones to 150 m depth, but the travel times of the fastest 10% of particles decreases by a factor of ∼2. Pumping distributions do not strongly affect travel times if irrigation remains shallow, but increases in the deep pumping rate substantially reduce travel times. Simulation of advective-dispersive transport with sorption shows that deep groundwater is protected from contamination over a sustainable timeframe (>1000 y) if the spatial distribution of Kd is uniform. However, if only low-K sediments sorb As, 30% of the aquifer is not protected. Results indicate that sustainable management strategies in the Bengal Basin should consider impacts of both physical and chemical heterogeneity, as well as their correlation. These insights from Bangladesh show that preferential flow strongly influences breakthrough of both conservative and reactive solutes even at large spatial scales, with implications for predicting water supply vulnerability in contaminated heterogeneous aquifers worldwide.

Use of MSE technology to stabilize highway embankments and slopes in Oklahoma.

DOT National Transportation Integrated Search

2009-09-30

Departments of transportation across the U.S., including ODOT, are invariably faced with a persistent problem of landslides and slope failures along highways. Repairs and maintenance work associated with these failures cost these agencies millions of...

Engineering study for reducing sign vandalism.

DOT National Transportation Integrated Search

1992-06-01

Sign vandalism has traditionally been a vexing problem for Iowa counties. : The extent of the cost and incidence of these acts have never been fully : ascertained, but a 1990 survey indicated that they cost Iowa counties more : than 1.5 million dolla...

Highway safety research : a national agenda : executive summary.

DOT National Transportation Integrated Search

2001-01-01

Motor vehicle-related injury and death is the nations largest public health problem. The economic costs to society : will approach $2 trillion and an even greater intangible human loss will occur to family and friends of the 33 million : victims. :...

Identifying Plant Poisoning in Livestock

USDA-ARS?s Scientific Manuscript database

Poisonous plant intoxication is a common and often deadly problem that annually costs the livestock industry more than $340 million in the western United States alone. Despite the cost or frequency, definitively identifying or diagnosing poisoning by plants in livestock is challenging. The purpos...

Real-time rideshare matching problem.

DOT National Transportation Integrated Search

2010-01-01

According to the Commuting in America report, more than 88% of American workers commute to work in private vehicles, which accounts for a daily sum of 166 million miles. The report also indicates that more than 76% of the commuters drive alone, resul...

The Career Cost: Does It Pay for a Military Pilot to Leave the Service for the Airlines?

DTIC Science & Technology

2015-06-01

significant decreases in retention can be attributed to perceived pay disparity between the airlines and military. The promise of high paying jobs ...experiencing a pilot retention problem that is getting worse. The government spends millions of dollars training pilots in the most advanced aircraft in...PAGE INTENTIONALLY LEFT BLANK v ABSTRACT The military is experiencing a pilot retention problem that is getting worse. The government spends

Is glucose-6-phosphate dehydrogenase deficiency more prevalent in Carrion's disease endemic areas in Latin America?

PubMed

Mazulis, Fernando; Weilg, Claudia; Alva-Urcia, Carlos; Pons, Maria J; Del Valle Mendoza, Juana

2015-12-01

Glucose-6-phosphate dehydrogenase (G6PD) is a cytoplasmic enzyme with an important function in cell oxidative damage prevention. Erythrocytes have a predisposition towards oxidized environments due to their lack of mitochondria, giving G6PD a major role in its stability. G6PD deficiency (G6PDd) is the most common enzyme deficiency in humans; it affects approximately 400 million individuals worldwide. The overall G6PDd allele frequency across malaria endemic countries is estimated to be 8%, corresponding to approximately 220 million males and 133 million females. However, there are no reports on the prevalence of G6PDd in Andean communities where bartonellosis is prevalent. Copyright © 2015 Hainan Medical College. Production and hosting by Elsevier B.V. All rights reserved.

Updates in the management of stable chronic obstructive pulmonary disease.

PubMed

Narsingam, Saiprasad; Bozarth, Andrew L; Abdeljalil, Asem

2015-01-01

Chronic obstructive pulmonary disease (COPD) is a preventable and treatable disease state characterized by persistent airflow limitation that is usually progressive and associated with an enhanced chronic inflammatory process. It is increasingly recognized as a major public health problem, affecting more than 20 million adults in the US. It is also recognized as a leading cause of hospitalizations and is the fourth leading cause of death in the US. The Global Initiative for Chronic Obstructive Lung Disease (GOLD) operates to promote evidence-based management of COPD, increase awareness and encourage research. In 2011, GOLD published a consensus report detailing evidence-based management strategies for COPD, which were last updated in 2015. In recent years, newer strategies and a growing number of new pharmacologic agents to treat symptoms of COPD have also been introduced and show promise in improving the management of COPD. We aim to provide an evidence-based review of the available and upcoming pharmacologic and non-pharmacologic treatment options for stable COPD, with continued emphasis on evidence-based management.

Economic costs of endemic non-filarial elephantiasis in Wolaita Zone, Ethiopia.

PubMed

Tekola, Fasil; Mariam, Damen H; Davey, Gail

2006-07-01

Endemic non-filarial elephantiasis or podoconiosis is a chronic and debilitating geochemical disease occurring in individuals exposed to red clay soil derived from alkalic volcanic rock. It is a major public health problem in countries in tropical Africa, Central America and North India. To estimate the direct and the average productivity cost attributable to podoconiosis, and to compare the average productivity time of podoconiosis patients with non-patients. Matched comparative cross sectional survey involving 702 study subjects (patients and non-patients) supplemented by interviews with key informants in Wolaita Zone, southern Ethiopia. Total direct costs of podoconiosis amounted to the equivalent of US$ 143 per patient per year. The total productivity loss for a patient amounted to 45% of the total working days per year, causing a monetary loss equivalent to US$ 63. In Wolaita zone, the overall cost of podoconiosis exceeds US$ 16 million per year. Podoconiosis has enormous economic impact in affected areas. Simple preventive measures (such as use of robust footwear) must be promoted by health policy makers.

Investigation of Solar Wind Correlations and Solar Wind Modifications Near Earth by Multi-Spacecraft Observations: IMP 8, WIND and INTERBALL-1

NASA Technical Reports Server (NTRS)

Paularena, Karolen I.; Richardson, John D.; Zastenker, Georgy N.

2002-01-01

The foundation of this Project is use of the opportunity available during the ISTP (International Solar-Terrestrial Physics) era to compare solar wind measurements obtained simultaneously by three spacecraft - IMP 8, WIND and INTERBALL-1 at wide-separated points. Using these data allows us to study three important topics: (1) the size and dynamics of near-Earth mid-scale (with dimension about 1-10 million km) and small-scale (with dimension about 10-100 thousand km) solar wind structures; (2) the reliability of the common assumption that solar wind conditions at the upstream Lagrangian (L1) point accurately predict the conditions affecting Earth's magnetosphere; (3) modification of the solar wind plasma and magnetic field in the regions near the Earth magnetosphere, the foreshock and the magnetosheath. Our Project was dedicated to these problems. Our research has made substantial contributions to the field and has lead others to undertake similar work.

Weathering the storm: hurricanes and birth outcomes.

PubMed

Currie, Janet; Rossin-Slater, Maya

2013-05-01

A growing literature suggests that stressful events in pregnancy can have negative effects on birth outcomes. Some of the estimates in this literature may be affected by small samples, omitted variables, endogenous mobility in response to disasters, and errors in the measurement of gestation, as well as by a mechanical correlation between longer gestation and the probability of having been exposed. We use millions of individual birth records to examine the effects of exposure to hurricanes during pregnancy, and the sensitivity of the estimates to these econometric problems. We find that exposure to a hurricane during pregnancy increases the probability of abnormal conditions of the newborn such as being on a ventilator more than 30min and meconium aspiration syndrome (MAS). Although we are able to reproduce previous estimates of effects on birth weight and gestation, our results suggest that measured effects of stressful events on these outcomes are sensitive to specification and it is preferable to use more sensitive indicators of newborn health. Copyright © 2013 Elsevier B.V. All rights reserved.

The use of H2 antagonists in treating and preventing NSAID-induced mucosal damage.

PubMed

Tuskey, Anne; Peura, David

2013-01-01

Pain affects the quality of life for millions of individuals and is a major reason for healthcare utilization. As populations age, medical personnel will need to manage more and more patients suffering from pain associated with degenerative and inflammatory musculoskeletal disorders. Nonsteroidal anti-inflammatory drugs (NSAIDs) are an effective treatment for both acute and chronic musculoskeletal pain; however, their use is associated with potentially significant gastrointestinal (GI) toxicity. Guidelines suggest various strategies to prevent problems in those at risk for NSAID-associated GI complications. In this article, we review the data supporting one such strategy - the use of histamine type-2 receptor antagonists (H2RAs) - for the prevention of GI adverse events in NSAID users. Older studies suggest that high-dose H2RAs are effective in preventing upper GI ulcers and dyspepsia. This suggestion was recently confirmed during clinical trials with a new ibuprofen/famotidine combination that reduced the risk of ulcers by 50% compared with ibuprofen alone.

Pick your poison: what's new in poison control for the preschooler.

PubMed

Glenn, Lauren

2015-01-01

Accidental childhood poisonings are a major public health concern despite many efforts to alleviate this problem. While the rate of pediatric fatalities due to poisonings have decreased over the last two decades, poison control centers around the US have collectively fielded over one million calls with regard to toxic exposures in the preschool age group. According to the American Association of Poison Control Centers nearly half of all human exposures reported last year involved children under six. By focusing poison prevention efforts on the preschooler, we can attempt to decrease morbidity and mortality in the most vulnerable age group affected. Although the subject is still prevalent, current discussion on this topic is limited. Newer literature discusses past initiatives such as child resistant packaging and sticker deterrent programs and addresses their efficacy. This article revisits older mechanisms of prevention as well as the science behind the human motivation to change one's own practice and behavior. Copyright © 2015 Elsevier Inc. All rights reserved.

The hydrodynamics of defecation

NASA Astrophysics Data System (ADS)

Yang, Patricia; Dao, Duc; Lehner, Richard; Tennenbaum, Mike; Fernandez-Nieves, Alberto; Hu, David

2014-11-01

According to the U.S. Department of Health and Human Services, digestive disease affects 60 to 70 million people and costs over 140 billion annually. Despite the significance of the gastrointestinal tract to human health, the physics of both digestion and defecation remain poorly understood. In this combined experimental and theoretical study, we investigate the defecation of mammals, from mice to elephants. We film defecation events at Zoo Atlanta and apply plate-on-plate rheometry to measure the viscosity of mammalian feces. Among animals heavier than 3 kg, we find herbivores defecate for only 10 seconds (N = 13), while carnivores do so for 19 seconds (N = 8). We rationalize this surprising trend on the basis of the higher viscosity of carnivore feces. We compare defecation times to theoretical predictions based on a Poiseuille flow model of the rectum and parallel experiments with a synthetic defecator that extrudes pizza dough upon applied pressure. Our findings may help to diagnose digestive problems in animals. Done...processed 2801 records...13:08:35

Impacts on groundwater recharge areas of megacity pumping: analysis of potential contamination of Kolkata, India, water supply

USGS Publications Warehouse

Sahu, Paulami; Michael, Holly A.; Voss, Clifford I.; Sikdar, Pradip K.

2013-01-01

Water supply to the world's megacities is a problem of quantity and quality that will be a priority in the coming decades. Heavy pumping of groundwater beneath these urban centres, particularly in regions with low natural topographic gradients, such as deltas and floodplains, can fundamentally alter the hydrological system. These changes affect recharge area locations, which may shift closer to the city centre than before development, thereby increasing the potential for contamination. Hydrogeological simulation analysis allows evaluation of the impact on past, present and future pumping for the region of Kolkata, India, on recharge area locations in an aquifer that supplies water to over 13 million people. Relocated recharge areas are compared with known surface contamination sources, with a focus on sustainable management of this urban groundwater resource. The study highlights the impacts of pumping on water sources for long-term development of stressed city aquifers and for future water supply in deltaic and floodplain regions of the world.

Wound Healing Problems in the Mouth

PubMed Central

Politis, Constantinus; Schoenaers, Joseph; Jacobs, Reinhilde; Agbaje, Jimoh O.

2016-01-01

Wound healing is a primary survival mechanism that is largely taken for granted. The literature includes relatively little information about disturbed wound healing, and there is no acceptable classification describing wound healing process in the oral region. Wound healing comprises a sequence of complex biological processes. All tissues follow an essentially identical pattern to complete the healing process with minimal scar formation. The oral cavity is a remarkable environment in which wound healing occurs in warm oral fluid containing millions of microorganisms. The present review provides a basic overview of the wound healing process and with a discussion of the local and general factors that play roles in achieving efficient would healing. Results of oral cavity wound healing can vary from a clinically healed wound without scar formation and with histologically normal connective tissue under epithelial cells to extreme forms of trismus caused by fibrosis. Many local and general factors affect oral wound healing, and an improved understanding of these factors will help to address issues that lead to poor oral wound healing. PMID:27853435

Protective Effects of Selected Botanical Agents on Bone.

PubMed

Jolly, James Jam; Chin, Kok-Yong; Alias, Ekram; Chua, Kien Hui; Soelaiman, Ima Nirwana

2018-05-11

Osteoporosis is a serious health problem affecting more than 200 million elderly people worldwide. The early symptoms of this disease are hardly detectable. It causes progressive bone loss, which ultimately renders the patients susceptible to fractures. Osteoporosis must be prevented because the associated fragility fractures result in high morbidity, mortality, and healthcare costs. Many plants used in herbal medicine contain bioactive compounds possessing skeletal protective effects. This paper explores the anti-osteoporotic properties of selected herbal plants, including their actions on osteoblasts (bone forming cells), osteoclasts (bone resorbing cells), and bone remodelling. Some of the herbal plant families included in this review are Berberidaceae, Fabaceae, Arecaceae, Labiatae, Simaroubaceaea, and Myrsinaceae. Their active constituents, mechanisms of action, and pharmaceutical applications were discussed. The literature shows that very few herbal plants have undergone human clinical trials to evaluate their pharmacological effects on bone to date. Therefore, more intensive research should be performed on these plants to validate their anti-osteoporotic properties so that they can complement the currently available conventional drugs in the battle against osteoporosis.

Health effects of indebtedness: a systematic review

PubMed Central

2014-01-01

Background In the aftermath of the global financial crisis, millions of households have been left with debts that they are unable to manage. Indebtedness may impair the wellbeing of those affected by it for years to come. This systematic review focuses on the long-term consequences of indebtedness on health. Methods The method used in the paper is a systematic review. First, bibliographic databases were searched for peer-reviewed articles. Second, the references and citations of the included articles were searched for additional articles. Results The results from our sample of 33 peer-reviewed studies demonstrate serious health effects related to indebtedness. Individuals with unmet loan payments had suicidal ideation and suffered from depression more often than those without such financial problems. Unpaid financial obligations were also related to poorer subjective health and health-related behaviour. Debt counselling and other programmes to mitigate debt-related stress are needed to alleviate the adverse effects of indebtedness on health. Conclusions The results demonstrate that indebtedness has serious effects on health. PMID:24885280

Autonomic Dysfunction and Risk Factors Associated with Trypanosoma cruzi Infection among Children in Arequipa, Peru

PubMed Central

Bowman, Natalie M.; Kawai, Vivian; Gilman, Robert H.; Bocangel, Cesar; Galdos-Cardenas, Gerson; Cabrera, Lilia; Levy, Michael Z.; Cornejo del Carpio, Juan Geny; Delgado, Freddy; Rosenthal, Lauren; Pinedo-Cancino, Vivian V.; Steurer, Francis; Seitz, Amy E.; Maguire, James H.; Bern, Caryn

2011-01-01

Chagas disease affects an estimated 8 million people in Latin America. Infected individuals have 20–30% lifetime risk of developing cardiomyopathy, but more subtle changes in autonomic responses may be more frequent. We conducted a matched case-control study of children in Arequipa, Peru, where triatomine infestation and Trypanosoma cruzi infection are emerging problems. We collected data on home environment, history, physical examination, electrocardiogram, and autonomic testing. Signs of triatomine infestation and/or animals sleeping in the child's room and household members with Chagas disease were associated with increased infection risk. Electrocardiogram findings did not differ between cases and controls. However, compared with control children, infected children had blunted autonomic responses by three different measures, the Valsalva maneuver, the cold pressor test, and the orthostatic test. T. cruzi-infected children show autonomic dysfunction, although the prognostic value of this finding is not clear. Sustained vector control programs are essential to decreasing future T. cruzi infections. PMID:21212207

Pathogenesis and pharmacologic treatment of obesity: the role of energy regulatory mechanism.

PubMed

Manulu, Mangatas S M; Sutanegara, I N Dwi

2006-01-01

Obesity has become a worldwide public health problem affecting millions of people. This is a chronic, stigmatized, and costly disease, rarely curable and is increasing in prevalence to a point today where we define obesity as an epidemic disease that not only in developed but also on developing countries. The pathogenesis of obesity is largely unknown, especially about energy regulatory mechanism that involved wide area of neuroendocrinology that is very interesting but very complex and makes internists "refuse" to learn. Obesity occurs through a longstanding imbalance between energy intake and energy expenditure, influenced by a complex biologic system that regulates appetite and adiposity. Obesity influences the pathogenesis of hypertension, type 2 diabetes, dyslipidemia, kidney, heart, and cerebrovascular disease. It is very wise for every internist to learn the pathogenesis and treatment of this worldwide diseases. Until now, the available treatments, including drugs, are palliative and are effective only while the treatment is being actively used; and besides so many side effects reported.

Hormones and tendinopathies: the current evidence.

PubMed

Oliva, Francesco; Piccirilli, Eleonora; Berardi, Anna C; Frizziero, Antonio; Tarantino, Umberto; Maffulli, Nicola

2016-03-01

Tendinopathies negatively affect the quality of life of millions of people, but we still do not know the factors involved in the development of tendon conditions. Published articles in English in PubMed and Google Scholar up to June 2015 about hormonal influence on tendinopathies onset. One hundred and two papers were included following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. In vitro and in vivo, tenocytes showed changes in their morphology and in their functional properties according to hormonal imbalances. Genetic pattern, sex, age and comorbidities can influence the hormonal effect on tendons. The increasing prevalence of metabolic disorders prompts to investigate the possible connection between metabolic problems and musculoskeletal diseases. The influence of hormones on tendon structure and metabolism needs to be further investigated. If found to be significant, multidisciplinary preventive and therapeutic strategies should then be developed. © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Most Common Foodborne Pathogens and Mycotoxins on Fresh Produce: A Review of Recent Outbreaks.

PubMed

Yeni, F; Yavaş, S; Alpas, H; Soyer, Y

2016-07-03

Every year millions of people are affected and thousands of them die due to infections and intoxication as a result of foodborne outbreaks, which also cause billions of dollars' worth of damage, public health problems, and agricultural product loss. A considerable portion of these outbreaks is related to fresh produce and caused by foodborne pathogens on fresh produce and mycotoxins. Escherichia coli O104:H4 outbreak, occurred in Germany in 2011, has attracted a great attention on foodborne outbreaks caused by contaminated fresh produce, and especially the vulnerability and gaps in the early warning and notification networks in the surveillance systems in all around the world. In the frame of this paper, we reviewed the most common foodborne pathogens on fresh produce, traceback investigations of the outbreaks caused by these pathogens, and lastly international early warning and notification systems, including PulseNet International and Rapid Alert System for Food and Feed, aiming to detect foodborne outbreaks.

Promising Gene Therapeutics for Salivary Gland Radiotoxicity

PubMed Central

Nair, Renjith Parameswaran; Sunavala-Dossabhoy, Gulshan

2017-01-01

More than 0.5 million new cases of head and neck cancer are diagnosed worldwide each year, and approximately 75% of them are treated with radiation alone or in combination with other cancer treatments. A majority of patients treated with radiotherapy develop significant oral off-target effects because of the unavoidable irradiation of normal tissues. Salivary glands that lie within treatment fields are often irreparably damaged and a decline in function manifests as dry mouth or xerostomia. Limited ability of the salivary glands to regenerate lost acinar cells makes radiation-induced loss of function a chronic problem that affects the quality of life of the patients well beyond the completion of radiotherapy. The restoration of saliva production after irradiation has been a daunting challenge, and this review provides an overview of promising gene therapeutics that either improve the gland’s ability to survive radiation insult, or alternately, restore fluid flow after radiation. The salient features and shortcomings of each approach are discussed. PMID:28286865

Weathering the Storm: Hurricanes and Birth Outcomes

PubMed Central

Currie, Janet

2013-01-01

A growing literature suggests that stressful events in pregnancy can have negative effects on birth outcomes. Some of the estimates in this literature may be affected by small samples, omitted variables, endogenous mobility in response to disasters, and errors in the measurement of gestation, as well as by a mechanical correlation between longer gestation and the probability of having been exposed. We use millions of individual birth records to examine the effects of exposure to hurricanes during pregnancy, and the sensitivity of the estimates to these econometric problems. We find that exposure to a hurricane during pregnancy increases the probability of abnormal conditions of the newborn such as being on a ventilator more than 30 minutes and meconium aspiration syndrome (MAS). Although we are able to reproduce previous estimates of effects on birth weight and gestation, our results suggest that measured effects of stressful events on these outcomes are sensitive to specification and it is preferable to use more sensitive indicators of newborn health. PMID:23500506

The use of H2 antagonists in treating and preventing NSAID-induced mucosal damage

PubMed Central

2013-01-01

Pain affects the quality of life for millions of individuals and is a major reason for healthcare utilization. As populations age, medical personnel will need to manage more and more patients suffering from pain associated with degenerative and inflammatory musculoskeletal disorders. Nonsteroidal anti-inflammatory drugs (NSAIDs) are an effective treatment for both acute and chronic musculoskeletal pain; however, their use is associated with potentially significant gastrointestinal (GI) toxicity. Guidelines suggest various strategies to prevent problems in those at risk for NSAID-associated GI complications. In this article, we review the data supporting one such strategy - the use of histamine type-2 receptor antagonists (H2RAs) - for the prevention of GI adverse events in NSAID users. Older studies suggest that high-dose H2RAs are effective in preventing upper GI ulcers and dyspepsia. This suggestion was recently confirmed during clinical trials with a new ibuprofen/famotidine combination that reduced the risk of ulcers by 50% compared with ibuprofen alone. PMID:24267478

Nanoencapsulation of benznidazole in calcium carbonate increases its selectivity to Trypanosoma cruzi.

PubMed

Tessarolo, Louise Donadello; de Menezes, Ramon Róseo Paula Pessoa Bezerra; Mello, Clarissa Perdigão; Lima, Dânya Bandeira; Magalhães, Emanuel Paula; Bezerra, Eveline Matias; Sales, Francisco Adilson Matos; Barroso Neto, Ito Liberato; Oliveira, Maria de Fátima; Dos Santos, Ricardo Pires; Albuquerque, Eudenilson L; Freire, Valder Nogueira; Martins, Alice Maria

2018-04-12

Chagas disease is a public health problem, affecting about 7 million people worldwide. Benznidazole (BZN) is the main treatment option, but it has limited effectiveness and can cause severe adverse effects. Drug delivery through nanoparticles has attracted the interest of the scientific community aiming to improve therapeutic options. The aim of this study was to evaluate the cytotoxicity of benznidazole-loaded calcium carbonate nanoparticles (BZN@CaCO3) on Trypanosoma cruzi strain Y. It was observed that BZN@CaCO3 was able to reduce the viability of epimastigote, trypomastigote and amastigote forms of T. cruzi with greater potency when compared with BZN. The amount of BZN necessary to obtain the same effect was up to 25 times smaller when loaded with CaCO3 nanoparticles. Also, it was observed that BZN@CaCO3 enhanced the selectivity index. Furthermore, the cell-death mechanism induced by both BZN and BZN@CaCO3 was evaluated, indicating that both substances caused necrosis and changed mitochondrial membrane potential.

Nursing research in heart failure care: a position statement of the american association of heart failure nurses (AAHFN).

PubMed

Stamp, Kelly D; Prasun, Marilyn; Lee, Christopher S; Jaarsma, Tiny; Piano, Mariann R; Albert, Nancy M

Heart Failure (HF) is a public health problem globally affecting approximately 6 million in the United States. A tailored position statement was developed by the American Association of Heart Failure Nurses (AAHFN) and their Research Consortium to assist researchers, funding institutions and policymakers with improving HF clinical advancements and outcomes. A comprehensive review was conducted using multiple search terms in various combinations to describe gaps in HF nursing science. Based on gaps described in the literature, the AAHFN made recommendations for future areas of research in HF. Nursing has made positive contributions through disease management interventions, however, quality, rigorous research is needed to improve the lives of patients and families while advancing nursing science. Advancing HF science is critical to managing and improving patient outcomes while promoting the nursing profession. Based on this review, the AAHFN is putting forth a call to action for research designs that promote validity, sustainability, and funding of future nursing research. Copyright © 2018 Elsevier Inc. All rights reserved.

Military women's risk factors for and symptoms of genitourinary infections during deployment.

PubMed

Lowe, Nancy K; Ryan-Wenger, Nancy A

2003-07-01

Symptoms of vaginitis and urinary tract infections are miserable, distracting, and significantly affect women's quality of life. Among civilian women, these symptoms account for 10.5 million office visits per year. To examine the scope of the problem for military women during deployment situations, surveys were sent to randomly selected Army and Navy units. Of 841 women who completed the anonymous survey and had been deployed, vaginal infections were experienced by 30.1% and urinary tract infections by 18.4% of them during deployment. Vaginal symptoms were consistent with symptoms associated with the three most common vaginal infections (candida, bacterial, and trichomonas vaginitis). A variety of risk factors, both behavioral and situational, significantly differentiated women with and without infections. Urinary tract infections and vaginal infections are common during deployment situations where resources for self-care and appropriate primary health care for women are scarce or unavailable. One solution is a self-diagnosis and treatment kit for deployed military women.

Recovery after Hip Fracture: Interventions and Their Timing to Address Deficits and Desired Outcomes – Evidence from the Baltimore Hip Studies

PubMed Central

Magaziner, Jay; Chiles, Nancy; Orwig, Denise

2017-01-01

Hip fracture is a significant public health problem affecting an estimated 1.6 million persons annually. The consequences of hip fracture are also significant, with more than half of those who sustain a fracture either dying or not returning to functional abilities present before fracture required to function independently. The Baltimore Hip Studies (BHS) is a program of research that for more than 30 years has been doing investigations to identify, develop, and evaluate strategies to optimize recovery from hip fracture. This paper provides an overview of known outcomes and recovery patterns following a hip fracture, which are derived primarily from the BHS. Target areas and timing for interventions based on this recovery sequence are suggested. The paper concludes with a discussion of some of the areas that the next generation of studies needs to concentrate on in order to advance knowledge about the care of hip fracture patients to maximize their recovery. PMID:26484873

The Association between Motivation, Affect, and Self-regulated Learning When Solving Problems

PubMed Central

Baars, Martine; Wijnia, Lisette; Paas, Fred

2017-01-01

Self-regulated learning (SRL) skills are essential for learning during school years, particularly in complex problem-solving domains, such as biology and math. Although a lot of studies have focused on the cognitive resources that are needed for learning to solve problems in a self-regulated way, affective and motivational resources have received much less research attention. The current study investigated the relation between affect (i.e., Positive Affect and Negative Affect Scale), motivation (i.e., autonomous and controlled motivation), mental effort, SRL skills, and problem-solving performance when learning to solve biology problems in a self-regulated online learning environment. In the learning phase, secondary education students studied video-modeling examples of how to solve hereditary problems, solved hereditary problems which they chose themselves from a set of problems with different complexity levels (i.e., five levels). In the posttest, students solved hereditary problems, self-assessed their performance, and chose a next problem from the set of problems but did not solve these problems. The results from this study showed that negative affect, inaccurate self-assessments during the posttest, and higher perceptions of mental effort during the posttest were negatively associated with problem-solving performance after learning in a self-regulated way. PMID:28848467

Using Technology to Improve Access to Mental Health Services.

PubMed

Cortelyou-Ward, Kendall; Rotarius, Timothy; Honrado, Jed C

Mental ill-health is a public health threat that is prevalent throughout the United States. Tens of millions of Americans have been diagnosed along the continuum of mental ill-health, and many more millions of family members and friends are indirectly affected by the pervasiveness of mental ill-health. Issues such as access and the societal stigma related to mental health issues serve as deterrents to patients receiving their necessary care. However, technological advances have shown the potential to increase access to mental health services for many patients.

Recommendations for Future Army Analysis Efforts. Volume 4. Key Questions and Recommendations for Future Analysis Efforts on Explaining the Army and Supporting the Soldier

DTIC Science & Technology

1988-04-14

McDonalds or Burger King for snack shops, Marriott for messing/billeting facilities, etc.? RECOMMENDED ELEMENTS OF ANALYSIS/TOPICAL AREAS: DATE RESULTS ITEM...e.g., a Burger King on post) now brings in about SI million per month to the family support coffers. It began in 1984 and has returned $21 million...Army, private sector franchises and family support. - The first or leading question is whether the family affects retention and, if so, what the Army

Children and divorce: overview and analysis.

PubMed

Behrman, R E

1994-01-01

Over the past two decades, more than one million children each year have experienced a family divorce, and the proportion of children affected by divorce is expected to grow substantially in the twenty-first century. Most of these children experience significant changes in their living arrangements, and the poverty rate for children of divorce is about twice the rate for all children in the United States. We are, therefore, devoting this issue of the journal to divorce because it is a crucial factor in the lives of millions of children in this country.

The worldwide epidemic of diabetic retinopathy

PubMed Central

Zheng, Yingfeng; He, Mingguang; Congdon, Nathan

2012-01-01

Diabetic retinopathy (DR), a major microvascular complication of diabetes, has a significant impact on the world's health systems. Globally, the number of people with DR will grow from 126.6 million in 2010 to 191.0 million by 2030, and we estimate that the number with vision-threatening diabetic retinopathy (VTDR) will increase from 37.3 million to 56.3 million, if prompt action is not taken. Despite growing evidence documenting the effectiveness of routine DR screening and early treatment, DR frequently leads to poor visual functioning and represents the leading cause of blindness in working-age populations. DR has been neglected in health-care research and planning in many low-income countries, where access to trained eye-care professionals and tertiary eye-care services may be inadequate. Demand for, as well as, supply of services may be a problem. Rates of compliance with diabetes medications and annual eye examinations may be low, the reasons for which are multifactorial. Innovative and comprehensive approaches are needed to reduce the risk of vision loss by prompt diagnosis and early treatment of VTDR. PMID:22944754

The worldwide epidemic of diabetic retinopathy.

PubMed

Zheng, Yingfeng; He, Mingguang; Congdon, Nathan

2012-01-01

Diabetic retinopathy (DR), a major microvascular complication of diabetes, has a significant impact on the world's health systems. Globally, the number of people with DR will grow from 126.6 million in 2010 to 191.0 million by 2030, and we estimate that the number with vision-threatening diabetic retinopathy (VTDR) will increase from 37.3 million to 56.3 million, if prompt action is not taken. Despite growing evidence documenting the effectiveness of routine DR screening and early treatment, DR frequently leads to poor visual functioning and represents the leading cause of blindness in working-age populations. DR has been neglected in health-care research and planning in many low-income countries, where access to trained eye-care professionals and tertiary eye-care services may be inadequate. Demand for, as well as, supply of services may be a problem. Rates of compliance with diabetes medications and annual eye examinations may be low, the reasons for which are multifactorial. Innovative and comprehensive approaches are needed to reduce the risk of vision loss by prompt diagnosis and early treatment of VTDR.

The economic cost of road traffic crashes in an urban setting

PubMed Central

García‐Altés, A; Pérez, K

2007-01-01

The objective of this article is to assess the total economic costs of road traffic crashes in Barcelona, a metropolitan city located in Southern Europe. A cost‐of‐illness study was conducted using a prevalence approximation, a societal and healthcare system perspective, and a 1‐year time horizon. Results were measured in terms of Euros in 2003. Total costs of road traffic crashes in Barcelona in 2003 were €367 million. Direct costs equalled €329 million (89.8% of total costs), including property damage costs, insurance administration costs and hospital costs. Police, emergency costs and transportation costs had a minimum effect on total direct costs. Indirect costs were €37 million, including lost productivity due to hospitalization and mortality. The results of the sensitivity analysis showed the upper limit of total economic cost of road traffic crashes in Barcelona to be €782 million. This is the first study to estimate the costs of road traffic crashes for a city in a developed country. The importance of the problem calls for further interventions to reduce road traffic crashes. PMID:17296693

Antimicrobial Resistance and Virulence: a Successful or Deleterious Association in the Bacterial World?

PubMed Central

Beceiro, Alejandro; Tomás, María

2013-01-01

SUMMARY Hosts and bacteria have coevolved over millions of years, during which pathogenic bacteria have modified their virulence mechanisms to adapt to host defense systems. Although the spread of pathogens has been hindered by the discovery and widespread use of antimicrobial agents, antimicrobial resistance has increased globally. The emergence of resistant bacteria has accelerated in recent years, mainly as a result of increased selective pressure. However, although antimicrobial resistance and bacterial virulence have developed on different timescales, they share some common characteristics. This review considers how bacterial virulence and fitness are affected by antibiotic resistance and also how the relationship between virulence and resistance is affected by different genetic mechanisms (e.g., coselection and compensatory mutations) and by the most prevalent global responses. The interplay between these factors and the associated biological costs depend on four main factors: the bacterial species involved, virulence and resistance mechanisms, the ecological niche, and the host. The development of new strategies involving new antimicrobials or nonantimicrobial compounds and of novel diagnostic methods that focus on high-risk clones and rapid tests to detect virulence markers may help to resolve the increasing problem of the association between virulence and resistance, which is becoming more beneficial for pathogenic bacteria. PMID:23554414

Understanding the Epidemiology of Heart Failure to Improve Management Practices: An Asia-Pacific Perspective.

PubMed

Rajadurai, Jeyamalar; Tse, Hung-Fat; Wang, Chao-Hung; Yang, Ning-I; Zhou, Jingmin; Sim, David

2017-04-01

Heart failure (HF) is a major global healthcare problem with an estimated prevalence of approximately 26 million. In Asia-Pacific regions, HF is associated with a significant socioeconomic burden and high rates of hospital admission. Epidemiological data that could help to improve management approaches to address this burden in Asia-Pacific regions are limited, but suggest patients with HF in the Asia-Pacific are younger and have more severe signs and symptoms of HF than those of Western countries. However, local guidelines are based largely on the European Society of Cardiology and American College of Cardiology Foundation/American Heart Association guidelines, which draw their evidence from studies where Western patients form the major demographic and patients from the Asia-Pacific region are underrepresented. Furthermore, regional differences in treatment practices likely affect patient outcomes. In the following review, we examine epidemiological data from existing regional registries, which indicate that these patients represent a distinct subpopulation of patients with HF. In addition, we highlight that patients with HF are under-treated in the region despite the existence of local guidelines. Finally, we provide suggestions on how data can be enriched throughout the region, which may positively affect local guidelines and improve management practices. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Managing Early Childhood Caries with Atraumatic Restorative Treatment and Topical Silver and Fluoride Agents

PubMed Central

Duangthip, Duangporn; Chen, Kitty Jieyi; Gao, Sherry Shiqian

2017-01-01

Early childhood caries (ECC) is a significant global health problem affecting millions of preschool children worldwide. In general, preschool children from families with 20% of the lowest family incomes suffered about 80% of the ECC. Most, if not all, surveys indicated that the great majority of ECC was left untreated. Untreated caries progresses into the dental pulp, causing pain and infection. It can spread systemically, affecting a child’s growth, development and general health. Fundamental caries management is based on the conventional restorative approach. Because preschool children are too young to cope with lengthy dental treatment, they often receive dental treatment under general anaesthesia from a specialist dentist. However, treatment under general anaesthesia poses a life-threatening risk to young children. Moreover, there are few dentists in rural areas, where ECC is prevalent. Hence, conventional dental care is unaffordable, inaccessible or unavailable in many communities. However, studies showed that the atraumatic restorative treatment had a very good success rate in treating dentine caries in young children. Silver diamine fluoride is considered safe and effective in arresting dentine caries in primary teeth. The aim of this paper is to review and discuss updated evidence of these alternative approaches in order to manage cavitated ECC. PMID:28994739

Clinical questions and the role CFD can play

NASA Astrophysics Data System (ADS)

Basu, Phd, Saikat; Kimbell, Phd, Julia S.; Zanation, Md, Adam M.; Ebert, Md, Charles S.; Senior, Md, Brent A.

2016-11-01

Use of computational fluid dynamics has revolutionized our perspectives on flow problems in engineering. These tools are however still underused in exploring clinical questions. Here we present some representative CFD-based findings that can improve current clinical practice. Chronic rhinosinusitis (CRS) is a complex inflammatory disease affecting over 11 million Americans yearly. It obstructs sinus pathways, thus hindering ventilation and clearance. Prescribed topical medications are often ineffective even after surgeries, partially owing to scanty drug delivery to the affected areas. We focus on improving the use of the most frequently used topical nasal sprays. From computed tomography (CT) scans, we develop 3D sinonasal airway models on the medical imaging software MimicsTM, which are then meshed using ICEM-CFDTM followed by airflow and particle simulations on FluentTM (v.14.5, ANSYS, Inc.). The results quantify aerosol particle delivery to target cavities before and after surgical alleviation. Various combinations of breathing techniques and head-nozzle orientations can increase target-site particle deposition over depositions using prevalent physician recommendations, and our findings facilitate identification of such optimal conditions. Supported by the National Institutes of Health (NIH) Grant R01 HL122154. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

Peripheral Artery Disease

MedlinePlus

... narrow or block the arteries and limit the flow of oxygen-rich blood to your body. Risk Factors Peripheral artery disease (P.A.D.) affects millions of people in the United States. The disease is more common in blacks than ...

64 Percent of Asian and Pacific Islander Treatment Admissions Name Alcohol as Their Problem

MedlinePlus

... 000 (1 percent) of the 1.8 million substance abuse admissions were APIs. Among all admissions, 60 percent ... AANHPI. aspx. Asian and Pacific Islander Admissions to Substance Abuse Treatment and Total Substance Abuse Treatment Admissions Reporting ...

Helping Struggling Teachers.

ERIC Educational Resources Information Center

Tucker, Pamela

2001-01-01

About 5 to 15 percent of teachers in 2.7 million public-education classrooms are marginal or incompetent. Assistance plans offer structure, purpose, and remedial help. Plans have six components: definition of the problem, statement of objectives, intervention strategies, a timeline, data-collection procedures, and final judgment. (MLH)

Biomass fuel combustion and health*

PubMed Central

de Koning, H. W.; Smith, K. R.; Last, J. M.

1985-01-01

Biomass fuels (wood, agricultural waste, and dung) are used by about half the world's population as a major, often the only, source of domestic energy for cooking and heating. The smoke emissions from these fuels are an important source of indoor air pollution, especially in rural communities in developing countries. These emissions contain important pollutants that adversely affect health—such as suspended particulate matter and polycyclic organic matter which includes a number of known carcinogens, such as benzo[a]pyrene, as well as gaseous pollutants like carbon monoxide and formaldehyde. Exposure to large amounts of smoke may present a health risk that is of a similar order of magnitude to the risk from tobacco smoke. The effects on health arising from exposure to air pollution are reviewed, based on what has been reported in the literature so far. Further and more detailed information on exposures and on the epidemiological aspects is urgently required. The persons most frequently affected are women who do the cooking for households in rural villages; they suffer from impaired health due to prolonged and repeated contact with these harmful pollutants. When they are pregnant, the developing fetus may also be exposed and this leads to the risk of excess deaths. In the developing countries, exposure to biomass fuel emissions is probably one of the most important occupational health hazards for women. A conservatively estimated 300-400 million people worldwide, mostly in the rural areas of developing countries, are affected by these problems. PMID:3872729

Early protein malnutrition negatively impacts physical growth and neurological reflexes and evokes anxiety and depressive-like behaviors.

PubMed

Belluscio, Laura M; Berardino, Bruno G; Ferroni, Nadina M; Ceruti, Julieta M; Cánepa, Eduardo T

2014-04-22

Malnutrition is a worldwide problem affecting millions of unborn and young children during the most vulnerable stages of their development. In humans, poor maternal nutrition is a major cause of intrauterine growth restriction which is associated with an increased risk of perinatal mortality and long-term morbidity. In addition, intrauterine growth restriction correlates with neurodevelopmental delays and alterations of brain structure and neurochemistry. While there is no doubt that maternal malnutrition is a principal cause of perturbed development of the fetal brain and that all nutrients have certain influence on brain maturation, proteins appear to be the most critical for the development of neurological functions. In the present study we assessed male and female mouse offspring, born to dams protein restricted during pregnancy and lactation, in physical growth and neurobehavioral development and also in social interaction, motivation, anxiety and depressive behaviors. Moreover, we evaluate the impact of the low protein diet on dams in relation to their maternal care and anxiety-related behavior given that these clearly affect pups development. We observed that maternal protein restriction during pregnancy and lactation delayed the physical growth and neurodevelopment of the offspring in a sex-independent manner. In addition, maternal undernutrition negatively affected offspring's juvenile social play, motivation, exploratory activity and risk assessment behaviors. These findings show that protein restriction during critical periods of development detrimentally program progeny behavior. Copyright © 2014 Elsevier Inc. All rights reserved.

In search of the silver bullet: regulatory models to address childhood obesity.

PubMed

Rothenberg, Joan R

2010-01-01

The concern over obesity today has evolved beyond an issue of personal vanity to a serious national health issue affecting millions of Americans. Obesity in children is especially alarming. Overweight children and adolescents are at risk for health problems throughout their lives. While under-nutrition or diet insufficiencies were once major obstacles in the development of healthy infants and children, the epidemic of childhood obesity marks the start of the 21st century with equally menacing health consequences. Childhood obesity creates an increased burden of disease on our economy with increased indirect economic costs of time lost from work for parents and time lost from school for the child. Data raise the possibility that the current generation of children could suffer greater illness or experience a shorter lifespan than that of their parents. Some experts believe that government mandated restrictions on dietary choices would alleviate the obesity problem, while others find such actions to be an unwarranted government intrusion. Still, as concerns about obesity continue to grow, especially regarding children, some say government intervention of some type is necessary to solve the problem. This paper examines the history and factors involved in the childhood obesity epidemic, explores regulatory options for its resolution, and provides an overview of obesity as a serious challenge to public health, and the health of children in particular. The federal agencies who share the responsibility for regulating food in the United States and their efforts to address the obesity problem are discussed as a background to various state and federal regulatory models influencing dietary choices. The effectiveness of proposed regulations and alternatives to government intervention suggest that the resolution of the childhood obesity issue requires a coordinated, multilevel approach.

The indirect costs of agency nurses in South Africa: a case study in two public sector hospitals

PubMed Central

Rispel, Laetitia C.; Moorman, Julia

2015-01-01

Background Globally, flexible work arrangements – through the use of temporary nursing staff – are an important strategy for dealing with nursing shortages in hospitals. Objective The objective of the study was to determine the direct and indirect costs of agency nurses, as well as the advantages and the problems associated with agency nurse utilisation in two public sector hospitals in South Africa. Methods Following ethical approval, two South African public sector hospitals were selected purposively. Direct costs were determined through an analysis of hospital expenditure information for a 5-year period from 2005 until 2010, obtained from the national transversal Basic Accounting System database. At each hospital, semi-structured interviews were conducted with the chief executive officer, executive nursing services manager, the maternity or critical care unit nursing manager, the human resource manager, and the finance manager. Indirect costs measured were the time spent on pre-employment checks, and nurse recruitment, orientation, and supervision. All expenditure is expressed in South African Rands (R: 1 USD=R7, 2010 prices). Results In the 2009/10 financial year, Hospital 1 spent R38.86 million (US$5.55 million) on nursing agencies, whereas Hospital 2 spent R10.40 million (US$1.49 million). The total estimated time spent per week on indirect cost activities at Hospital 1 was 51.5 hours, and 60 hours at Hospital 2. The estimated monetary value of this time at Hospital 1 was R962,267 (US$137,467) and at Hospital 2 the value was R300,121 (US$42,874), thus exceeding the weekly direct costs of nursing agencies. Agency nurses assisted the selected hospitals in dealing with problems of nurse recruitment, absenteeism, shortages, and skills gaps in specialised clinical areas. The problems experienced with agency nurses included their perceived lack of commitment, unreliability, and providing sub-optimal quality of patient care. Conclusion Hospital managers and policy-makers need to address the effective utilisation of agency nurses and quality of patient care in tandem. PMID:25971399

World health dilemmas: Orphan and rare diseases, orphan drugs and orphan patients

PubMed Central

Kontoghiorghe, Christina N; Andreou, Nicholas; Constantinou, Katerina; Kontoghiorghes, George J

2014-01-01

According to global annual estimates hunger/malnutrition is the major cause of death (36 of 62 million). Cardiovascular diseases and cancer (5.44 of 13.43 million) are the major causes of death in developed countries, while lower respiratory tract infections, human immunodeficiency virus infection/acquired immunodeficiency syndrome, diarrhoeal disease, malaria and tuberculosis (10.88 of 27.12 million) are the major causes of death in developing countries with more than 70% of deaths occurring in children. The majority of approximately 800 million people with other rare diseases, including 100000 children born with thalassaemia annually receive no treatment. There are major ethical dilemmas in dealing with global health issues such as poverty and the treatment of orphan and rare diseases. Of approximately 50000 drugs about 10% are orphan drugs, with annual sales of the latter approaching 100 billion USD. In comparison, the annual revenue in 2009 from the top 12 pharmaceutical companies in Western countries was 445 billion USD and the top drug, atorvastatin, reached 100 billion USD. In the same year, the total government expenditure for health in the developing countries was 410 billion USD with only 6%-7% having been received as aid from developed countries. Drugs cost the National Health Service in the United Kingdom more than 20 billion USD or 10% of the annual health budget. Uncontrollable drug prices and marketing policies affect global health budgets, clinical practice, patient safety and survival. Fines of 5.3 billion USD were imposed on two pharmaceutical companies in the United States, the regulatory authority in France was replaced and clinicians were charged with bribery in order to overcome recent illegal practises affecting patient care. High expenditure for drug development is mainly related to marketing costs. However, only 2 million USD was spent developing the drug deferiprone (L1) for thalassaemia up to the stage of multicentre clinical trials. The criteria for drug development, price levels and use needs to be readdressed to improve drug safety and minimise costs. New global health policies based on cheaper drugs can help the treatment of many categories of orphan and rare diseases and millions of orphan patients in developing and developed countries. PMID:25332915

World health dilemmas: Orphan and rare diseases, orphan drugs and orphan patients.

PubMed

Kontoghiorghe, Christina N; Andreou, Nicholas; Constantinou, Katerina; Kontoghiorghes, George J

2014-09-26

According to global annual estimates hunger/malnutrition is the major cause of death (36 of 62 million). Cardiovascular diseases and cancer (5.44 of 13.43 million) are the major causes of death in developed countries, while lower respiratory tract infections, human immunodeficiency virus infection/acquired immunodeficiency syndrome, diarrhoeal disease, malaria and tuberculosis (10.88 of 27.12 million) are the major causes of death in developing countries with more than 70% of deaths occurring in children. The majority of approximately 800 million people with other rare diseases, including 100000 children born with thalassaemia annually receive no treatment. There are major ethical dilemmas in dealing with global health issues such as poverty and the treatment of orphan and rare diseases. Of approximately 50000 drugs about 10% are orphan drugs, with annual sales of the latter approaching 100 billion USD. In comparison, the annual revenue in 2009 from the top 12 pharmaceutical companies in Western countries was 445 billion USD and the top drug, atorvastatin, reached 100 billion USD. In the same year, the total government expenditure for health in the developing countries was 410 billion USD with only 6%-7% having been received as aid from developed countries. Drugs cost the National Health Service in the United Kingdom more than 20 billion USD or 10% of the annual health budget. Uncontrollable drug prices and marketing policies affect global health budgets, clinical practice, patient safety and survival. Fines of 5.3 billion USD were imposed on two pharmaceutical companies in the United States, the regulatory authority in France was replaced and clinicians were charged with bribery in order to overcome recent illegal practises affecting patient care. High expenditure for drug development is mainly related to marketing costs. However, only 2 million USD was spent developing the drug deferiprone (L1) for thalassaemia up to the stage of multicentre clinical trials. The criteria for drug development, price levels and use needs to be readdressed to improve drug safety and minimise costs. New global health policies based on cheaper drugs can help the treatment of many categories of orphan and rare diseases and millions of orphan patients in developing and developed countries.

The effectiveness of health care cost management strategies: a review of the evidence.

PubMed

Fronstin, P

1994-10-01

This Issue Brief discusses the evolution of the health care delivery and financing systems and its effects on health care cost management and describes the changes in the health care delivery system as they pertain to managed care. It presents empirical evidence on the effectiveness of managed care and concludes with an analysis of the potential of future health care reform to influence the evolution of the health care delivery system and affect health care costs. Between 1987 and 1993, total enrollment in health maintenance organizations (HMOs) increased from 28.6 million to 39.8 million, representing an additional 11.2 million individuals, or 4 percent of the U.S. population. At the same time, new forms of managed care organizations emerged. Enrollment in preferred provider organizations increased from 12.2 million individuals in 1987 to 58 million in 1992, and enrollment in point-of-service plans increased from virtually none in 1987 to 2.3 million individuals in 1992. In addition, the percentage of traditional fee-for-service plans with some form of utilization review increased to 95 percent in 1990 from 41 percent in 1987. Measuring the effects of the changing delivery system on the costs and quality of health care services has been a difficult task, resulting in considerable disagreement as to whether or not costs have been affected. In a recent report, the Congressional Budget Office recognizes two new major findings. First, managed care can provide cost-effective health care at a level of quality comparable with the care typically provided by a fee-for-service plan. Second, independent practice associations can be as effective as group- or staff-model HMOs under certain conditions. In the future, we are likely to see a continued movement of Americans into managed care arrangements, an increase in the number of physicians forming networks, a reduction in the number of insurers, an increase in the number of employers joining coalitions to purchase health care services for their employees, and a health care system that is generally more concentrated and vertically integrated.

Global drought and severe drought-affected populations in 1.5 and 2 °C warmer worlds

NASA Astrophysics Data System (ADS)

Liu, Wenbin; Sun, Fubao; Lim, Wee Ho; Zhang, Jie; Wang, Hong; Shiogama, Hideo; Zhang, Yuqing

2018-03-01

The 2015 Paris Agreement proposed a more ambitious climate change mitigation target on limiting global warming to 1.5 °C instead of 2 °C above preindustrial levels. Scientific investigations on environmental risks associated with these warming targets are necessary to inform climate policymaking. Based on the Coupled Model Intercomparison Project phase 5 (CMIP5) climate models, we present the first risk-based assessment of changes in global drought and the impact of severe drought on populations from additional 1.5 and 2 °C warming conditions. Our results highlight the risk of drought on a global scale and in several hotspot regions such as the Amazon, northeastern Brazil, southern Africa and Central Europe at both 1.5 and 2 °C global warming relative to the historical period, showing increases in drought durations from 2.9 to 3.2 months. Correspondingly, more total and urban populations would be exposed to severe droughts globally (+132.5 ± 216.2 million and +194.5 ± 276.5 million total population and +350.2 ± 158.8 million and +410.7 ± 213.5 million urban populations in 1.5 and 2 °C warmer worlds) and regionally (e.g., East Africa, West Africa and South Asia). Less rural populations (-217.7 ± 79.2 million and -216.2 ± 82.4 million rural populations in 1.5 and 2 °C warmer worlds) would be exposed to severe drought globally under climate warming, population growth and especially the urbanization-induced population migration. By keeping global warming at 1.5 °C above the preindustrial levels instead of 2 °C, there is a decrease in drought risks (i.e., less drought duration, less drought intensity and severity but relatively more frequent drought) and the affected total, urban and rural populations would decrease globally and in most regions. While challenging for both East Africa and South Asia, the benefits of limiting warming to below 1.5 °C in terms of global drought risk and impact reduction are significant.

Egypt: urban growth encroaches on farmland.

PubMed

1981-12-01

In 1980 Egypt's population was 42 million, with 9 million, or 21%, residing in metropolitan Cairo. Throughout the country the urban population makes up about 44% of the total population; in the 2 largest cities, Cairo and Alexandria, public utilities and basic services are becoming more and more ineffective. The problem is complicated by the fact that the urban population is concentrated along the Nile valley, which is the most fertile, cultivated, and well watered area of the country. An estimated 20,000 acres of farmland are lost each year to urban spread, while the government spends an average $2 million yearly to subsidize food imports. The Egyptian government is not only aiming at reducing natural growth through the provision of free family planning services, but it is encouraging rural development and trying to raise the standard of living for farmers. A strategy to redistribute the population into smaller cities or on land suitable for reclamation is also being planned.

The logic of causation and the risk of paralytic poliomyelitis for an American child.

PubMed Central

Ridgway, D.

2000-01-01

Beginning in January 1997, American immunization policy allowed parents and physicians to elect one of three approved infant vaccination strategies for preventing poliomyelitis. Although the three strategies likely have different outcomes with respect to prevention of paralytic poliomyelitis, the extreme rarity of the disease in the USA prevents any controlled comparison. In this paper, a formal inferential logic, originally described by Donald Rubin, is applied to the vaccination problem. Assumptions and indirect evidence are used to overcome the inability to observe the same subjects under varying conditions to allow the inference of causality from non-randomized observations. Using available epidemiologic information and explicit assumptions, it is possible to project the risk of paralytic polio for infants immunized with oral polio vaccine (1.3 cases per million vaccinees), inactivated polio vaccine (0.54 cases per million vaccinees), or a sequential schedule (0.54-0.92 cases per million vaccinees). PMID:10722138

Estimated value of insurance premium due to Citarum River flood by using Bayesian method

NASA Astrophysics Data System (ADS)

Sukono; Aisah, I.; Tampubolon, Y. R. H.; Napitupulu, H.; Supian, S.; Subiyanto; Sidi, P.

2018-03-01

Citarum river flood in South Bandung, West Java Indonesia, often happens every year. It causes property damage, producing economic loss. The risk of loss can be mitigated by following the flood insurance program. In this paper, we discussed about the estimated value of insurance premiums due to Citarum river flood by Bayesian method. It is assumed that the risk data for flood losses follows the Pareto distribution with the right fat-tail. The estimation of distribution model parameters is done by using Bayesian method. First, parameter estimation is done with assumption that prior comes from Gamma distribution family, while observation data follow Pareto distribution. Second, flood loss data is simulated based on the probability of damage in each flood affected area. The result of the analysis shows that the estimated premium value of insurance based on pure premium principle is as follows: for the loss value of IDR 629.65 million of premium IDR 338.63 million; for a loss of IDR 584.30 million of its premium IDR 314.24 million; and the loss value of IDR 574.53 million of its premium IDR 308.95 million. The premium value estimator can be used as neither a reference in the decision of reasonable premium determination, so as not to incriminate the insured, nor it result in loss of the insurer.

Global magnitude of visual impairment caused by uncorrected refractive errors in 2004

PubMed Central

Pascolini, Donatella; Mariotti, Silvio P; Pokharel, Gopal P

2008-01-01

Abstract Estimates of the prevalence of visual impairment caused by uncorrected refractive errors in 2004 have been determined at regional and global levels for people aged 5 years and over from recent published and unpublished surveys. The estimates were based on the prevalence of visual acuity of less than 6/18 in the better eye with the currently available refractive correction that could be improved to equal to or better than 6/18 by refraction or pinhole. A total of 153 million people (range of uncertainty: 123 million to 184 million) are estimated to be visually impaired from uncorrected refractive errors, of whom eight million are blind. This cause of visual impairment has been overlooked in previous estimates that were based on best-corrected vision. Combined with the 161 million people visually impaired estimated in 2002 according to best-corrected vision, 314 million people are visually impaired from all causes: uncorrected refractive errors become the main cause of low vision and the second cause of blindness. Uncorrected refractive errors can hamper performance at school, reduce employability and productivity, and generally impair quality of life. Yet the correction of refractive errors with appropriate spectacles is among the most cost-effective interventions in eye health care. The results presented in this paper help to unearth a formerly hidden problem of public health dimensions and promote policy development and implementation, programmatic decision-making and corrective interventions, as well as stimulate research. PMID:18235892

Schema Knowledge for Solving Arithmetic Story Problems: Some Affective Components.

ERIC Educational Resources Information Center

Marshall, Sandra P.

This report discusses the role of affect in cognitive processing. The importance of affect in processing mathematical information is described in the context of solving arithmetic story problems. Some ideas are offered about the way affective responses to mathematical problem solving situations influence the development, maintenance, and retrieval…

Sentiment Propagation in Social Networks: A Case Study in LiveJournal

NASA Astrophysics Data System (ADS)

Zafarani, Reza; Cole, William D.; Liu, Huan

Social networking websites have facilitated a new style of communication through blogs, instant messaging, and various other techniques. Through collaboration, millions of users participate in millions of discussions every day. However, it is still difficult to determine the extent to which such discussions affect the emotions of the participants. We surmise that emotionally-oriented discussions may affect a given user's general emotional bent and be reflected in other discussions he or she may initiate or participate in. It is in this way that emotion (or sentiment) may propagate through a network. In this paper, we analyze sentiment propagation in social networks, review the importance and challenges of such a study, and provide methodologies for measuring this kind of propagation. A case study has been conducted on a large dataset gathered from the LiveJournal social network. Experimental results are promising in revealing some aspects of the sentiment propagation taking place in social networks.

Air Pollution, Oxidative Stress, and Alzheimer's Disease

PubMed Central

Moulton, Paula Valencia; Yang, Wei

2012-01-01

Alzheimer's disease (AD) is the most common form of dementia affecting millions of people worldwide and will continue to affect millions more with population aging on the rise. AD causality is multifactorial. Known causal factors include genetic predisposition, age, and sex. Environmental toxins such as air pollution (AP) have also been implicated in AD causation. Exposure to AP can lead to chronic oxidative stress (OS), which is involved in the pathogenesis of AD. Whereas AP plays a role in AD pathology, the epidemiological evidence for this association is limited. Given the significant prevalence of AP exposure combined with increased population aging, epidemiological evidence for this link is important to consider. In this paper, we examine the existing evidence supporting the relationship between AP, OS, and AD and provide recommendations for future research on the population level, which will provide evidence in support of public health interventions. PMID:22523504

Can Homeopathic Arsenic Remedy Combat Arsenic Poisoning in Humans Exposed to Groundwater Arsenic Contamination?: A Preliminary Report on First Human Trial

PubMed Central

2005-01-01

Groundwater arsenic (As) has affected millions of people globally distributed over 20 countries. In parts of West Bengal (India) and Bangladesh alone, over 100 million people are at risk, but supply of As-free water is grossly inadequate. Attempts to remove As by using orthodox medicines have mostly been unsuccessful. A potentized homeopathic remedy, Arsenicum Album-30, was administered to a group of As affected people and thereafter the As contents in their urine and blood were periodically determined. The activities of various toxicity marker enzymes and compounds in the blood, namely aspartate amino transferase, alanine amino transferase, acid phosphatase, alkaline phosphatase, lipid peroxidation and reduced glutathione, were also periodically monitored up to 3 months. The results are highly encouraging and suggest that the drug can alleviate As poisoning in humans. PMID:16322812

Genetics of Age-Related Macular Degeneration: Current Concepts, Future Directions

PubMed Central

DeAngelis, Margaret M.; Silveira, Alexandra C.; Carr, Elizabeth A.; Kim, Ivana K.

2014-01-01

Age-related macular degeneration (AMD) is a progressive degenerative disease which leads to blindness, affecting the quality of life of millions of Americans. More than 1.75 million individuals in the United States are affected by the advanced form of AMD. The etiological pathway of AMD is not yet fully understood, but there is a clear genetic influence on disease risk. To date, the 1q32 (CFH) and 10q26 (PLEKHA1/ARMS2/HTRA1) loci are the most strongly associated with disease; however, the variation in these genomic regions alone is unable to predict disease development with high accuracy. Therefore, current genetic studies are aimed at identifying new genes associated with AMD and their modifiers, with the goal of discovering diagnostic or prognostic biomarkers. Moreover, these studies provide the foundation for further investigation into the pathophysiology of AMD by utilizing a systems-biology-based approach to elucidate underlying mechanistic pathways. PMID:21609220

Downgrading, downsizing, degazettement, and reclassification of protected areas in Brazil.

PubMed

Bernard, E; Penna, L A O; Araújo, E

2014-08-01

Protected areas (PAs) are key elements for biodiversity conservation and ecosystem services. Brazil has the largest PA system in the world, covering approximately 220 million ha. This system expanded rapidly in the mid-1990s to the mid-2000s. Recent events in Brazil, however, have led to an increase in PA downgrading, downsizing, and degazettement (PADDD). Does this reflect a shift in the country's PA policy? We analyzed the occurrence, frequency, magnitude, type, spatial distribution, and causes of changes in PA boundaries and categories in Brazil. We identified 93 PADDD events from 1981 to 2012. Such events increased in frequency since 2008 and were ascribed primarily to generation and transmission of electricity in Amazonia. In Brazilian parks and reserves, 7.3 million ha were affected by PADDD events, and of these, 5.2 million ha were affected by downsizing or degazetting. Moreover, projects being considered by the Federal Congress may degazette 2.1 million ha of PA in Amazonia alone. Relaxing the protection status of existing PAs is proving to be politically easy in Brazil, and the recent increase in frequency and extension of PADDD reflects a change in governmental policy. By taking advantage of chronic deficiencies in financial and personnel resources and surveillance, disputes over land tenure, and the slowness of the Brazilian justice, government agencies have been implementing PADDD without consultation of civil society. If parks and reserves are to maintain their integrity, there will need to be investments in Brazilian PAs and a better understanding of the benefits PAs provide. © 2014 Society for Conservation Biology.

Renewed mobilization against malaria.

PubMed

1991-01-01

1 million people die in the world from malaria annually, 800,000 of whom are 5 year old children in Sub-Sahara Africa. Further it affects 270 million people. In fact, 110 million develop malaria, 90 million of whom are from Sub-Saharan Africa. Thus WHO has introduced a new world initiative for malaria control to reverse the worsening trend that began in the mid 1970s. In October 1991, 150 officials from 50 African, Asian, and Latin American countries and participants from UN cooperation and development agencies and bilateral agencies attended an interregional conference at the WHO Regional office for Africa in Brazzaville, Congo. It strove to evaluate malaria situations specific to Africa, to update the malaria control plan in Africa, and to contribute to the development of an implementable world strategy. This world strategy needs to consider the local situation and encourage participation of the government and people of affected countries. Further individuals, communities, and various sectors of the national economy including those involved in health, education, development, and agriculture need to participate in malaria control. In addition, for this strategy to work, most countries must strengthen the management and financing of health services to meet their needs. For example, local populations must share local operating costs such as those for essential drugs and mosquito control operations. Community participation must also include personal protection such as impregnated bed nets and environmental measures. Besides malaria control must be integrated into the existing health system at country, provincial, and peripheral levels. In sum, improved case management, control of malaria transmission, and prevention and control of epidemics form the basis for the new strategy.

UNICEF and the Sudan.

ERIC Educational Resources Information Center

United Nations Children's Fund, Nairobi (Kenya). Eastern Africa Regional Office.

Coupled with poor infrastructure, vast distances, and harsh climatic conditions, the enormous physical obstacles in the Sudan (Africa's largest country) have combined to produce extremely serious problems for Sudanese children, who will soon constitute half of the 17 million people there. This booklet describes continuing projects implemented by…

Floor Health

ERIC Educational Resources Information Center

High, Jacalyn

2010-01-01

Poor indoor air quality (IAQ) in schools and universities contributes to absenteeism and reduced performance. The American Lung Association estimates that U.S. students miss more than 14 million school days a year because of asthma, allergies and other respiratory problems exacerbated by poor IAQ. Fortunately, maintenance departments in education…

A Liberal Education.

ERIC Educational Resources Information Center

Doyle, Denis P.

2001-01-01

If user-friendliness is the key to widespread technological penetration, what education is needed for the high-tech world? For our nation's 281 million technology users, a liberal education trumps technology training. Liberally schooled people gain the power to reason, solve problems, exercise initiative, and think clearly and imaginatively-all…

Cultural beliefs and values in cancer patients.

PubMed

Daher, M

2012-04-01

In 2008, the International Agency for Research on Cancer (IARC) released its World Cancer Report, which indicated that cancer accounts for approximately 12% of all-cause mortality worldwide. IARC estimated that globally 7.6 million people died from cancer and that 12.4 million new cases were diagnosed in 2008. The report went on to project that, due to increases in life expectancy, improvements in clinical diagnostics, and shifting trends in health behaviors (e.g. increases in smoking and sedentary lifestyles), in the absence of significant efforts to improve global cancer control, cancer mortality could increase to 12.9 million and cancer incidence to 20 million by the year 2030. Looking deeper into the data, it becomes clear that cancer-related stigma and myths about cancer are important problems that must be addressed, although different from a country to another. Stigmas about cancer present significant challenges to cancer control: stigma can have a silencing effect, whereby efforts to increase cancer awareness are negatively affected. The social, emotional, and financial devastation that all too often accompanies a diagnosis of cancer is, in large part, due to the cultural myths and taboos surrounding the disease. Combating stigma, myths, taboos, and overcoming silence will play important roles in changing this provisional trajectory. There are several reasons that cancer is stigmatized. Many people in our area perceived cancer to be a fatal disease. Cancer symptoms or body parts affected by the disease can cultivate stigma. Fears about treatment can also fuel stigma. There was evidence of myths associated with cancer, such as the belief that cancer is contagious, or cancer may be seen as a punishment. After reviewing these different examples of cultural myths and taboos met in cancer care, we can report these lessons learned: 1. Around the world, cancer continues to carry a significant amount of stigma, myths, and taboos; however, there are opportunities to capitalize upon shifting perceptions and positive change. 2. Awareness of cancer prevention, early detection, treatment, and survival are on the rise; however, too many people still report that they feel uninformed when it comes to cancer. 3. Communication is critical to decreasing cancer-related stigma, raising cancer awareness, and disseminating cancer education. People with a personal history of cancer-especially well-known or celebrity survivors-and multiple mass media channels are key resources for dissemination. 4. The school system represents a potential venue for cancer education, and increasing cancer awareness among children may be an investment with high returns. 5. When facing cancer, people around the world want information and emotional support for themselves and their families. 6. Tobacco use and poor nutrition are widely acknowledged as cancer risks. Programs and policies that help people translate this awareness into action are needed. The global cancer community should capitalize upon positive shifts in attitudes about awareness of cancer and leverage these shifts to develop, and disseminate effective media campaigns and behavioral interventions to decrease the incidence of and morbidity and mortality associated with cancer.

On the Design and Test of a Liquid Injection Electric Thruster

NASA Technical Reports Server (NTRS)

Jones, T. A.; Kenney, J. T.; Youmans, E. H.

1973-01-01

A liquid injection electric thruster (LINJET) was designed and tested. The results of the tests were very encouraging with thruster performance levels well in excess of design goals. Supporting activities to the engine design and test included a five-million pulse life test on the main capacitor, a 46-million pulse test on the trigger electronics, design and fabrication of a zero resistance torque connector for use with the torsional pendulum thrust stand, design and fabrication of a logic box for control of engine firing, and a physical and chemical properties characterization of the perfluorocarbon propellant. While the results were encouraging, testing was limited, as many problems existed with the design. The most significant problem was involved with excessive propellant flow which contributed to false triggering and shorting. Low power active thermal control of the propellant storage cavity, coupled with a re-evaluation of the injection ring pore size and area exposed to the main capacitor discharge are areas that should be investigated should this design be carried forward.

Smart battery controller for lithium sulfur dioxide batteries

NASA Astrophysics Data System (ADS)

Atwater, Terrill; Bard, Arnold; Testa, Bruce; Shader, William

1992-08-01

Each year, the U.S. Army purchases millions of lithium sulfur dioxide batteries for use in portable electronics equipment. Because of their superior rate capability and service life over a wide variety of conditions, lithium batteries are the power source of choice for military equipment. There is no convenient method of determining the available energy remaining in partially used lithium batteries; hence, users do not take full advantage of all the available battery energy. Currently, users replace batteries before each mission, which leads to premature disposal, and results in the waste of millions of dollars in battery energy every year. Another problem of the lithium battery is that it is necessary to ensure complete discharge of the cells when the useful life of the battery has been expended, or when a hazardous condition exists; a hazardous condition may result in one or more of the cells venting. The Electronics Technology and Devices Laboratory has developed a working prototype of a smart battery controller (SBC) that addresses these problems.