Principles of Adaptive Array Processing

DTIC Science & Technology

2006-09-01

ACE with and without tapering (homogeneous case). These analytical results are less suited to predict the detection performance of a real system ...Nickel: Adaptive Beamforming for Phased Array Radars. Proc. Int. Radar Symposium IRS’98 (Munich, Sept. 1998), DGON and VDE /ITG, pp. 897-906.(Reprint also...strategies for airborne radar. Asilomar Conf. on Signals, Systems and Computers, Pacific Grove, CA, 1998, IEEE Cat.Nr. 0-7803-5148-7/98, pp. 1327-1331. [17

Finite-beta equilibria for Wendelstein 7-X configurations using the Princeton Iterative Equilibrium Solver code

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arndt, S.; Merkel, P.; Monticello, D.A.

Fixed- and free-boundary equilibria for Wendelstein 7-X (W7-X) [W. Lotz {ital et al.}, {ital Plasma Physics and Controlled Nuclear Fusion Research 1990} (Proc. 13th Int. Conf. Washington, DC, 1990), (International Atomic Energy Agency, Vienna, 1991), Vol. 2, p. 603] configurations are calculated using the Princeton Iterative Equilibrium Solver (PIES) [A. H. Reiman {ital et al.}, Comput. Phys. Commun., {bold 43}, 157 (1986)] to deal with magnetic islands and stochastic regions. Usually, these W7-X configurations require a large number of iterations for PIES convergence. Here, two methods have been successfully tested in an attempt to decrease the number of iterations neededmore » for convergence. First, periodic sequences of different blending parameters are used. Second, the initial guess is vastly improved by using results of the Variational Moments Equilibrium Code (VMEC) [S. P. Hirshmann {ital et al.}, Phys. Fluids {bold 26}, 3553 (1983)]. Use of these two methods have allowed verification of the Hamada condition and tendency of {open_quotes}self-healing{close_quotes} of islands has been observed. {copyright} {ital 1999 American Institute of Physics.}« less

Reliability Evaluation of Computer Systems.

DTIC Science & Technology

1981-01-01

algorithms in hardware is not restricted by the designs of particular circuits. Applications could be made in new computer architectures; one candidate...pp. 137-148, IEEE, Chicago, Illinois, September 1963. (With J.F. Wakerly ) "Design of Low-Cost General-Purpose Self- Diagnosing Computers," Proc...34 Proc., IEEE Int’l Solid-State Circuits Conference, Philadelphia, Pennsylvania, February 16-18, 1977. (With J.F. Wakerly ) "Microcomputers in the

Dynamic Reconfiguration and Link Fault Tolerance in a Transputer Network

DTIC Science & Technology

1989-06-01

linkO and link3 are connected to the C004s. LinkI and link2 are routed to the P2 edge connector, labelled ConfigUp and ConfiDown for access to...various commands recieved PROC handle.screen (VAL BYTE link.byte, SEQ -place the first byte on screen (source) I F1 linki < 16 -- a link 0 SEQ line.num l...determine characters used on screen for -- display of source & dest IF ((INT(bytel)) < 32) linki : to.slot[INT(bytel)] otherwise linki : 10 IF ((INT(byte2

Research Directions in Database Security, II

DTIC Science & Technology

1990-11-01

WILLIAMS Burke Ct 286 WOLCOTT 9th Rd 795 WOOD 25th St 520 YANCEY Motley St 398 ZUZACK Arden Rd LDV> : The style of the prototype is such that the...WOLCOTT Fin Clk YANCEY Dept Mgr ZUZACK Proc Anal LDV> ;RR3: S (sortrel (project (njoin (project employee-base ’(Department Employee-Name Employee-Num...Proc Anal PROC MAHONEY Secy PROC YANCEY Dept Mgr PROC ZUZACK Proc Anal SEC BRIMER DMSO SEC FALBO Secy SEC HILL Dept Mgr SEC MITCHELL Ast DBSO SEC THOMAS

URREF Reliability Versus Credibility in Information Fusion

DTIC Science & Technology

2013-07-01

Fusion, Vol. 3, No. 2, December, 2008. [31] E. Blasch, J. Dezert, and P. Valin , “DSMT Applied to Seismic and Acoustic Sensor Fusion,” Proc. IEEE Nat...44] E. Blasch, P. Valin , E. Bossé, “Measures of Effectiveness for High- Level Fusion,” Int. Conference on Information Fusion, 2010. [45] X. Mei, H...and P. Valin , “Information Fusion Measures of Effectiveness (MOE) for Decision Support,” Proc. SPIE 8050, 2011. [49] Y. Zheng, W. Dong, and E

Proceedings of the International Conference on Parallel Architectures and Compilation Techniques Held 24-26 August 1994 in Montreal, Canada

DTIC Science & Technology

1994-08-26

an Itegrated Circuit Global Router. In Proc. of PPEARS 88, pages 138-145, 1988. [7] S. Sakai, Y. Yamaguchi, K. Hiraki , Y. Kodama, and T. Yuba. An...Computer Architecture, 1992. [5] S. Sakai, Y. Yamaguchi, K. Hiraki , Y. Kodama, and T. Yuba. An architecture of a data-flow single chip processor. In Int...EM-4 and sparing time for tech- nical discussions. We also thank Prof. Kei Hiraki at the Univ. of Tokyo for his helpful comments. Hidehiko Masuhara’s

Finite-element modeling of soft tissue rolling indentation.

PubMed

Sangpradit, Kiattisak; Liu, Hongbin; Dasgupta, Prokar; Althoefer, Kaspar; Seneviratne, Lakmal D

2011-12-01

We describe a finite-element (FE) model for simulating wheel-rolling tissue deformations using a rolling FE model (RFEM). A wheeled probe performing rolling tissue indentation has proven to be a promising approach for compensating for the loss of haptic and tactile feedback experienced during robotic-assisted minimally invasive surgery (H. Liu, D. P. Noonan, B. J. Challacombe, P. Dasgupta, L. D. Seneviratne, and K. Althoefer, "Rolling mechanical imaging for tissue abnormality localization during minimally invasive surgery, " IEEE Trans. Biomed. Eng., vol. 57, no. 2, pp. 404-414, Feb. 2010; K. Sangpradit, H. Liu, L. Seneviratne, and K. Althoefer, "Tissue identification using inverse finite element analysis of rolling indentation," in Proc. IEEE Int. Conf. Robot. Autom. , Kobe, Japan, 2009, pp. 1250-1255; H. Liu, D. Noonan, K. Althoefer, and L. Seneviratne, "The rolling approach for soft tissue modeling and mechanical imaging during robot-assisted minimally invasive surgery," in Proc. IEEE Int. Conf. Robot. Autom., May 2008, pp. 845-850; H. Liu, P. Puangmali, D. Zbyszewski, O. Elhage, P. Dasgupta, J. S. Dai, L. Seneviratne, and K. Althoefer, "An indentation depth-force sensing wheeled probe for abnormality identification during minimally invasive surgery," Proc. Inst. Mech. Eng., H, vol. 224, no. 6, pp. 751-63, 2010; D. Noonan, H. Liu, Y. Zweiri, K. Althoefer, and L. Seneviratne, "A dual-function wheeled probe for tissue viscoelastic property identification during minimally invasive surgery," in Proc. IEEE Int. Conf. Robot. Autom. , 2008, pp. 2629-2634; H. Liu, J. Li, Q. I. Poon, L. D. Seneviratne, and K. Althoefer, "Miniaturized force indentation-depth sensor for tissue abnormality identification," IEEE Int. Conf. Robot. Autom., May 2010, pp. 3654-3659). A sound understanding of wheel-tissue rolling interaction dynamics will facilitate the evaluation of signals from rolling indentation. In this paper, we model the dynamic interactions between a wheeled probe and a soft tissue sample using the ABAQUS FE software package. The aim of this work is to more precisely locate abnormalities within soft tissue organs using RFEM and hence aid surgeons to improve diagnostic ability. The soft tissue is modeled as a nonlinear hyperelastic material with geometrical nonlinearity. The proposed RFEM was validated on a silicone phantom and a porcine kidney sample. The results show that the proposed method can predict the wheel-tissue interaction forces of rolling indentation with good accuracy and can also accurately identify the location and depth of simulated tumors.

Hypersonic Shock Wave Computations Using the Generalized Boltzmann Equation

NASA Astrophysics Data System (ADS)

Agarwal, Ramesh; Chen, Rui; Cheremisin, Felix G.

2006-11-01

Hypersonic shock structure in diatomic gases is computed by solving the Generalized Boltzmann Equation (GBE), where the internal and translational degrees of freedom are considered in the framework of quantum and classical mechanics respectively [1]. The computational framework available for the standard Boltzmann equation [2] is extended by including both the rotational and vibrational degrees of freedom in the GBE. There are two main difficulties encountered in computation of high Mach number flows of diatomic gases with internal degrees of freedom: (1) a large velocity domain is needed for accurate numerical description of the distribution function resulting in enormous computational effort in calculation of the collision integral, and (2) about 50 energy levels are needed for accurate representation of the rotational spectrum of the gas. Our methodology addresses these problems, and as a result the efficiency of calculations has increased by several orders of magnitude. The code has been validated by computing the shock structure in Nitrogen for Mach numbers up to 25 including the translational and rotational degrees of freedom. [1] Beylich, A., ``An Interlaced System for Nitrogen Gas,'' Proc. of CECAM Workshop, ENS de Lyon, France, 2000. [2] Cheremisin, F., ``Solution of the Boltzmann Kinetic Equation for High Speed Flows of a Rarefied Gas,'' Proc. of the 24th Int. Symp. on Rarefied Gas Dynamics, Bari, Italy, 2004.

Improved Design of Stellarator Coils for Current Carrying Plasmas

NASA Astrophysics Data System (ADS)

Drevlak, M.; Strumberger, E.; Hirshman, S.; Boozer, A.; Brooks, A.; Valanju, P.

1998-11-01

The method of automatic optimization (P. Merkel, Nucl. Fus. 27), (1987) 867; P. Merkel, M. Drevlak, Proc 25th EPS Conf. on Cont. Fus. and Plas. Phys., Prague, in print. for the design of stellarator coils consists essentially of determining filaments such that the average relative field error int dS [ (B_coil + B_j) \\cdot n]^2/B^2_coil is minimized on the prescribed plasma boundary. Bj is the magnetic field produced by the plasma currents of the given finite β fixed boundary equilibrium. For equilibria of the W7-X type, Bj can be neglected, because of the reduced parallel plasma currents. This is not true for quasi-axisymmetric stellarator (QAS) configurations (A. Reiman, et al., to be published.) with large equilibrium and net plasma (bootstrap) currents. Although the coils for QAS exhibit low values of the field error, free boundary calculations indicate that the shape of the plasma is usually not accurately reproduced , particularly when saddle coils are used. We investigate if the surface reconstruction can be improved by introducing a modified measure of the field error based on a measure of the resonant components of the normal field.

Understanding Thermal Equilibrium through Activities

ERIC Educational Resources Information Center

Pathare, Shirish; Huli, Saurabhee; Nachane, Madhura; Ladage, Savita; Pradhan, Hemachandra

2015-01-01

Thermal equilibrium is a basic concept in thermodynamics. In India, this concept is generally introduced at the first year of undergraduate education in physics and chemistry. In our earlier studies (Pathare and Pradhan 2011 "Proc. episteme-4 Int. Conf. to Review Research on Science Technology and Mathematics Education" pp 169-72) we…

Efficient Effects-Based Military Planning Final Report

DTIC Science & Technology

2010-11-13

using probabilistic infer- ence methods,” in Proc. 8th Annu. Conf. Uncertainty Artificial Intelli - gence (UAI), Stanford, CA. San Mateo, CA: Morgan...Imprecise Probabilities, the 24th Conference on Uncertainty in Artificial Intelligence (UAI), 2008. 7. Yan Tong and Qiang Ji, Learning Bayesian Networks...Bayesian Networks using Constraints Cassio P. de Campos cassiopc@acm.org Dalle Molle Institute for Artificial Intelligence Galleria 2, Manno 6928

Evaluation of Available Software for Reconstruction of a Structure from its Imagery

DTIC Science & Technology

2017-04-01

Math . 2, 164–168. Lowe, D. G. (1999) Object recognition from local scale-invariant features, in Proc. Int. Conf. Computer Vision, Vol. 2, pp. 1150–1157...Marquardt, D. (1963) An algorithm for least-squares estimation of nonlinear parameters, SIAM J. Appl. Math . 11(2), 431–441. UNCLASSIFIED 11 DST-Group–TR

Symetries et integrabilite des equations aux differences finies

NASA Astrophysics Data System (ADS)

Lafortune, Stephane

2000-09-01

La présente thèse porte sur l'étude des symétries et des propriétés d'intégrabilité des équations aux différences finies. Dans le chapitre 1, le groupe de symétrie ponctuelle d'un système couplé à deux équations différentielles aux différences est étudié. On montre que dans certains cas, la dimension du groupe peut être infinie. Les équations peuvent décrire l'interaction de deux longues chaînes moléculaires, chacune étant composée d'atomes d'un même type. Dans le chapitre 2, une classe de théories de champs avec interaction exponentielle est introduite. L'interaction dépend de deux matrices de ``couplage'' et est suffisamment générale pour inclure toutes les théories de champs de Toda existant dans la littérature. Les symétries de Lie ponctuelles sont obtenues pour les cas où l'on a un nombre fini, infini ou semi-infini de champs. Une attention spéciale est accordée à la présence de l'invariance conforme. Dans le chapitre 3, nous procédons à la classification et à l'étude d'équations linéarisables. Nous examinons tout d'abord l'équation de Gambier continue qui contient, comme réductions, toutes les équations de deuxième ordre intégrables par linéarisation. Nous introduisons par la suite la forme discrète de cette équation et obtenons les conditions d'intégrabilité à l'aide du confinement des singularités. Nous étudions aussi les différentes réductions du cas discret. De plus, nous obtenons des transformations de Schlesinger pour les équations de Gambier discrète et continue. Dans la dernière partie du chapitre, nous étudions une famille d'équations discrètes du deuxième ordre incluant des équations résolubles par linéarisation. Plusieurs cas intégrables sont obtenus. Dans le cas discret, l'étude de l'intégrabilité est faite à l'aide du confinement des singularités. Dans le chapitre 4, nous étudions un autre critère d'intégrabilité: l'entropie algébrique. Nous montrons que les résultats obtenus avec ce critère pour les équations linéarisables sont les mêmes que ceux obtenus avec le confinement des singularités. Nous obtenons de plus une méthode algorithmique pour la détection de la linéarisabilité. Le chapitre 5 est consacré à l'étude d'équations du troisième ordre. Nous obtenons des équations intégrables par des couplages d'équations du premier et du deuxième ordre. Les équations continues sont étudiées à l'aide de l'analyse de Painlevé et le confinement des singularités est utilisé dans le cas discret.

The Nereus Hybrid Underwater Robotic Vehicle for Global Ocean Science Operations to 11,000m Depth

DTIC Science & Technology

2008-09-01

B. Butler. Field trials of the Theseus AUV. Proc. Int. Symp. on Unmanned Untethered Submersible Technology, page 615, 1995. [9] R. M. Eustice, L. L...pages 4257–4264, Apr. 2007. [10] J. Ferguson, A. Pope, B. Butler, and R. Verrall. Theseus AUV-two record breaking missions. Sea Technology, 40(2):65

Phonon Self-Energies in Weakly and Strongly Anharmonic Systems.

DTIC Science & Technology

1980-12-11

Flammarion : Paris, 1978), p. 142. 37. W. Cochran, Adv. in Phys. 9, 387 (1960). 38. P.W. Anderson, Fiz. Dielectrik (Akad. Nauk. SSR) (1970). 39. R.A. Cowley...katiyar, J.F. Ryan and J.F. Scott, in Proc. Int. Conf. on Light Scattering in Solidq ( Flammarion , Paris 1971) p4 36 . i[ p -56- 43. R.P. Lowndes, N.E

Scattering of Acoustic Waves from Ocean Boundaries

DTIC Science & Technology

2013-09-30

of predictive models that can account for the all of the physical processes and variability of acoustic propagation and scattering in ocean...collaboration with Dr. Nicholas Chotiros, particularly for theoretical development of bulk acoustic /sediment modeling and laser roughness measurements...G. Potty and J. Miller. Measurement and modeling of Scholte wave dispersion in coastal waters. In Proc. of Third Int. Conf. on Ocean Acoustics

The statistical model of origin and evolution planets of Solar system and planetary satellities

NASA Astrophysics Data System (ADS)

Krot, A.

There are the theories for exploring Solar system formation in accord Titius-Bode's low: electromagnetic theories (Birkeland (1912), Alfven (1942)), gravitational theories (Schmidt (1944), Woolfson (1964), Safronov (1969), Dole (1970)), nebular theories (Weizsaecker (1943), Kuiper (1949), Nakano (1970)) [1]-[3]. In spite of great number of work aimed to exploring formation of the Solar system, however, the mentioned theories were not able to explain all phenomena. In this connection the statistical theory for a cosmological body forming (so-called the spheroidal body model) has been proposed in [4]-[11]. Within the framework of this theory, bodies have fuzzy outlines and are represented by means of spheroidal forms. In the work [6], which is a continuation of the papers [4], [5], it has been investigated a slowly evolving in time process of a gravitational compression of a spheroidal body close to an unstable equilibrium state. In the papers [7],[8]the equation of motion of particles inside the weakly gravitating spheroidal body modeled by means of an ideal liquid has been obtained. Using Schwarzschild's and Kerr's metrics a consistency of the proposed statistical model with the general relativity has been shown in [12]. The proposed theory proceeds from the conception for forming a spheroidal body as a protoplanet from planetary nebula; it permits to derive the form of distribution functions for an immovable and rotating spheroidal body [4]-[6],[10]-[13] as well as their density masses (gravitational potentials and strengths) and also to find the distribution function of specific angular momentum of the rotating uniformly spheroidal body [13],[14]. Using the specific angular momentum distribution function this work considers a gas- dust protoplanetary cloud as a rotating and gravitating spheroidal body. Because the specific angular momenta are averaged during conglomeration process the specific angular momenta for a planets of Solar system is found. As a result a new low for Solar system planetary distances is derived (it generalizes the well-known Schmidt low). The new low gives a very good estimation of real planetary distances in Solar system (the relative error of estimation is 0%; absolute error of estimation is 0,5% besides its maximal value is equal to 5% for Earth and Pluto). This low has been applied also to estimation of Jupiter's satellities distances in this work. References: [1] M.M.Nieto, The Tutius-Bode low of planetary distances: its his-tory and theory. Pergamon: Oxford, New York et., 1972. [2] V.S. Safronov, Evolution of Protoplanetary cloud and the formation of the Earth and planets. 1969, Moscow, Nauka, (in Russian); NASA Tech. Transl. F-677, Washington, D.C. 1972. [3] A.V. Vityazev, G.V. Pechrnikova and V.S.Safronov, The Terrestrial planets: origin and early evolution. 1990. Moscow, Nauka (in Russian) [4] A.M.Krot, Achievement in Modern Radioelectronics (Special issue "Cosmic Radiophysics", Moscow), no.8, pp.66-81, 1996 (in Russian). [5] A.M.Krot, Proc. SPIE's 13th Annual Intern.Symp. "AeroSense", vol.3710, pp.1248-1259, Orlando, Florida, USA, April 5-9, 1999. [6] A.M.Krot, Proc. SPIE's 14th Annual Intern.Symp. "AeroSense", vol.4038, pp.1318-1329, Orlando, Florida, USA, April 24-28, 2000. [7] A.M.Krot, Proc. SPIE's 15th Annual Intern. Symposium "AeroSense", vol.4394, pp.1271-1282, Orlando, Florida, USA, April 16-20, 2001. [8] A.M.Krot, Proc. 53rd Intern. Astronautical Congress: The World Space Congress-2002, Houston, Texas, USA, October 10-19, 2002, Preprint IAC-02-J.P.01. - 11 p. [9] A.M.Krot, Proc. 34th Scientific Assembly of the Committee on Space Research (COSPAR)- The 2nd World Space Congress (WSC- 2002), October 10-19, 2002,Houston, Texas, USA. [10] A.M.Krot, Proc. of EGS- AGU-EUG Joint Assembly, Nice, France, April 6-11, 2003, Geophysical Research Abstracts, vol.5, EAE03-À-05568, 2003. [11] A.M. Krot, Proc. of 54 Intern. Astronautical Congress (IAC), September 29-October 3, 2003, Bremen, Germany, Preprint IAC-03-J.1.08. -11p. [12] A.M.Krot , Proc. of 35th COSPAR Scientific Assembly, Paris, France, July 18-25, 2004, Abstract-Nr. COSPAR 04-A-00162. [13] A.Krot, Proc. EGU- 2nd General Assembly, Vienna, Austria, April 24-29, 2005, Geophysical Research Abstracts, vol.7, EGU05-A-04550, 2005; SRef-ID: 1607-7962/gra/. [14] A.Krot Proc. EGU- General Assembly, Vienna, Austria, April 02- 07, 2006, Geophysical Research Abstracts, vol.8, EGU06-A-00216, 2006; SRef-ID: 1607-7962/gra/. 2

75 FR 32306 - Perishable Agricultural Commodities Act: Impact of Post-Default Agreements on Trust Protection...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-08

...); American Banana Co. v. Republic Nat. Bank of N.Y., 362 F.3d 33 (2nd Cir. 2004); Patterson Frozen Foods, Inc. v. Crown Foods, Int'l, 307 F.3d 666, 667 (7th Cir. 2002); Greg Orchards Produce, Inc. v. P. Roncone J., 180 F.3d 888, 892 (7th Cir. 1999); Idahoan Fresh v. Advantage Produce, Inc., 157 F.3d 197, 205...

Simulation of the Thermal Response of Externally Cooled Ordnance Engulfed in Large Aviation Fuel Fires

DTIC Science & Technology

1990-09-01

400j.GE T (Io 1Q0 .(MELT ViH N- T ?A( 11 3 7( 2,( 1 TBEFORE AVG TEMP(OF) L] SIDE INTERFACE TE.M1P CALCULATE THERMAL CONDUCTIVITY CALCULATION | L... ISTE a AVG TEMP EXPLOSIVE SIDE OF INTERFACE AE-0 SLIU INT 00726 ENERGY GENERATED IS. (INT).LT. T •ELT(EXPL) T 0 EI"E’rNG I CALCULATE NEWl TEMP WIlTH

Processes in KaffeOS: Isolation, Resource Management, and Sharing in Java

DTIC Science & Technology

2000-04-01

separation of garbage collection costs is not possible. Balfanz and Gong [2] describe a multi- processing JVM developed to explore the secu- rity...line in Java. In Proc. of the 7th HotOS, Rio Rico, AZ, Mar. 1999. IEEE Computer Society. [2] D. Balfanz and L. Gong. Experience with secure multi

CrossTalk: The Journal of Defense Software Engineering. Volume 19, Number 11

DTIC Science & Technology

2006-11-01

8>. 7. Wallace, Delores R. Practical Soft- ware Reliability Modeling. Proc. of the 26th Annual NASA Goddard Software Engineering Workshop, Nov. 2001...STAR WARS TO STAR TREK To Request Back Issues on Topics Not Listed Above, Please Contact <stsc. customerservice@hill.af.mil>. About the Authors Kym

76 FR 20217 - Perishable Agricultural Commodities Act: Impact of Post-Default Agreements on Trust Protection...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-12

... N.Y., 362 F.3d 33 (2nd Cir. 2004); Patterson Frozen Foods, Inc. v. Crown Foods, Int'l, 307 F.3d 666, 667 (7th Cir. 2002); Greg Orchards Produce, Inc. v. P. Roncone J., 180 F.3d 888, 892 (7th Cir. 1999); Idahoan Fresh v. Advantage Produce, Inc., 157F.3d 197, 205 (3d Cir. 1998); In re Lombardo Fruit and...

Flexible Parsing.

DTIC Science & Technology

1986-06-30

Machine Studies .. 14. Minton, S. N., Hayes, P. J., and Fain, J. E. Controlling Search in Flexible Parsing. Proc. Ninth Int. Jt. Conf. on Artificial...interaction through the COUSIN command interface", International Journal of Man- Machine Studies , Vol. 19, No. 3, September 1983, pp. 285-305. 8...in a gracefully interacting user interface," "Dynamic strategy selection in flexible parsing," and "Parsing spoken language: a semantic case frame

Thermal decomposition of gaseous ammonium nitrate at low pressure: kinetic modeling of product formation and heterogeneous decomposition of nitric acid.

PubMed

Park, J; Lin, M C

2009-12-03

The thermal decomposition of ammonium nitrate, NH(4)NO(3) (AN), in the gas phase has been studied at 423-56 K by pyrolysis/mass spectrometry under low-pressure conditions using a Saalfeld reactor coated with boric acid. The sublimation of NH(4)NO(3) at 423 K was proposed to produce equal amounts of NH(3) and HNO(3), followed by the decomposition reaction of HNO(3), HNO(3) + M --> OH + NO(2) + M (where M = third-body and reactor surface). The absolute yields of N(2), N(2)O, H(2)O, and NH(3), which can be unambiguously measured and quantitatively calibrated under a constant pressure at 5-6.2 torr He are kinetically modeled using the detailed [H,N,O]-mechanism established earlier for the simulation of NH(3)-NO(2) (Park, J.; Lin, M. C. Technologies and Combustion for a Clean Environment. Proc. 4th Int. Conf. 1997, 34-1, 1-5) and ADN decomposition reactions (Park, J.; Chakraborty, D.; Lin, M. C. Proc. Combust. Inst. 1998, 27, 2351-2357). Since the homogeneous decomposition reaction of HNO(3) itself was found to be too slow to account for the consumption of reactants and the formation of products, we also introduced the heterogeneous decomposition of HNO(3) in our kinetic modeling. The heterogeneous decomposition rate of HNO(3), HNO(3) + (B(2)O(3)/SiO(2)) --> OH + NO(2) + (B(2)O(3)/SiO(2)), was determined by varying its rate to match the modeled result to the measured concentrations of NH(3) and H(2)O; the rate could be represented by k(2b) = 7.91 x 10(7) exp(-12 600/T) s(-1), which appears to be consistent with those reported by Johnston and co-workers (Johnston, H. S.; Foering, L.; Tao, Y.-S.; Messerly, G. H. J. Am. Chem. Soc. 1951, 73, 2319-2321) for HNO(3) decomposition on glass reactors at higher temperatures. Notably, the concentration profiles of all species measured could be satisfactorily predicted by the existing [H,N,O]-mechanism with the heterogeneous initiation process.

The Second Great Thermal Event from the History of the Solar System as Origin of the Lunar Asymmetries and Paleomagnetism

NASA Astrophysics Data System (ADS)

Neagu, A.

1993-07-01

To explain the origin of the natural remanent magnetism (NRM) of lunar rocks [1,2] and lunar asymmetries [3-5], many models suppose an asymmetric arrangement of matter within the early Moon [6,7]. Presented here is a model of lunar evolution that explains both the appearance of the lunar asymmetries and the presence of a high lunar palaeomagnetic field in the vicinity of 3.9 Ga starting from a symmetrically differentiated Moon. According to this model, less than 0.2 Ga after its formation as a completely molten planetary body, the Moon differentiated in concentric layers to form an anorthositic crust, a mantle, and an iron core [8]. Lunar asymmetries appeared at about 3.9 Ga ago when the Sun underwent a very violent explosive phase, generating the second great thermal event (SGTE) from the history of the solar system. Solar plasma into expansion interacted with the solar system bodies, erasing previous records on a large part of their surfaces and generating thermal effects of various kinds. Figure 1 presents the manner in which the solar plasma "excavated" within the lunar crust. The result was the displacement of the lunar center-of-figure (CF) and center-of mass (CM) from O in their present positions [3-5]. A similar "excavation" within the primordial crust of the Earth generated the appearance of a protocontinental land (Proto-Pangaea). Eccentric placement of the lunar core immediately after SGTE occurrence and its movement toward the new position of the lunar CM, along with change of the lunar spin into a synchronous rotation, generated lunar internal motions vigorously enough to drive lunar dynamo. Figure 2 presents the lunar palaeomagnetic field intensity as a function of time according to this scenario. Immediately after SGTE occurrence, the lunar crust was subjected to intensive bombardment with impacting masses belonging to Population II impactors [9]. The larger impacts generated zones of weakness and fissures within the lunar crust, but the isostatic answer of the lunar interior and its asymmetric structure permitted mare volcanism to occur only on the nearside [10]. This model is strongly supported by isotopic, petrologic, and magnetic analyses of lunar nearside rocks that give abundant evidence for a widespread thermal metamorphism at about 3.9 Ga. It is reflected especially in partial to complete equilibration of the isotopic systems [8], in the redistribution of volatiles on lunar surface [11-13] and in the thermoremanent magnetization of lunar breccias [14]. This model also explains the asymmetric distribution of the thorium concentrations in the lunar surface [15] and the presence, near the lunar surface, of rocks of deep-seated origin [16]. References: [1] Nagata T. et al. (1970) Proc. Apollo 11 LSC, 2325. [2] Strangway D. W. (1971) EPSL, 13, 43. [3] Kaula W. M. et al. (1972) Proc. LSC 3rd, 2189. [4] Kaula W. M. et al. (1974) Proc. LSC 5th, 3049. [5] Haines E. L. and Metzger A. E. (1980) Proc. LPSC 11th, 689. [6] Stevenson D. J. (1980) Nature, 287, 520. [7] Ransford G. and Sjogren W. (1972) Nature, 238, 260. [8] Wasserburg G. J. et al. (1977) Phil. Trans. R. Soc. Lond., A285, 7. [9] Neagu A. (1993) 18th EGS Meeting, Wiesbaden. [10] Neagu A. (1992) Meteoritics, 27, 267. [11] Tera F. and Wasserburg G. J. (1972) EPSL, 14, 281. [12] Nunes P. D. and Tatsumoto M. (1973) Science, 182, 916. [13] Cirlin E. H. and Housley R. M. (1980) Proc. LPSC 11th, 349. [14] Gose W. A. et al. (1978) EPSL, 38, 373. [15] Metzger A. E. et al. (1977) Proc. LSC 8th, 949. [16] James O. B. (1980) Proc. LPSC 11th, 365. Fig. 1, which appears here in the hard copy, shows a schematic equatorial cross section of the Moon showing the lunar internal structure before and after SGTE occurred. Fig. 2 appears here in the hard copy.

Security Games Applied to Real-World: Research Contributions and Challenges

DTIC Science & Technology

2012-01-01

Marecki, J.: GUARDS and PROTECT: Next Generation Applications of Security Games . SIGECOM 10 (March 2011) 31–34 4. Shieh, E ., An, B., Yang, R., Tambe...Steigerwald, E .: GUARDS - Game Theoretic Security Allocation on a National Scale. In: Proc. of The 10th International Conference on Autonomous Agents...Shieh, E ., Kiekintveld, C.: Refinement of Strong Stackelberg Equilibria in Security Games . In: Proc. of the 25th Conference on Artificial Intelligence

Final Panel Report on Allergenics

Center for Biologics Evaluation and Research (CBER)

... It il;l J:l'1t! op:i.qion .o;th~ Panel t.ha,t t;h~r~. is non~w ra:v:l,cl~;nC7~i!, to sug~~t;:I,t ,that proc~~~gq ~u+l?at;r~~e :$,ou;r~~ Qt.sp,e~ira!3~P,~};f:f,Jc ...

Service-Oriented Access Control

DTIC Science & Technology

2014-09-01

root bridge for each VLAN, all such that traffic cost is minimized. Sung et al. define this cost as the sum of broadcast traffic, inter-VLAN data...Merlin,” in Proc. 12th ACM Workshop on Hot Topics in Networks, College Park, MD, 2013, pp. 24:1–24:7. [10] A. Voellmy and P. Hudak, “ Nettle : Taking the

PROUST: Knowledge-Based Program Understanding.

DTIC Science & Technology

1983-08-01

undeniably yes. If anything, PROUST is the minimum that is required! The basis for this conclusion is twofold: 1. In Artificial Intelligence research...Role of Plans in Intellegent Teaching Systems. In Brown, J. S. and Sleeman, D. (editors), Intellegent Tutoring Systems. New York. 1981. [8] Goldstein, I...95, 1978. (12] Rich, C. A Formal Representation for Plans in the Programmer’s Apprentice. In Proc. of the Seventh Int. Joint Conf. on Artificial

Interaction Among Inhomogeneities.

DTIC Science & Technology

1980-12-01

imposed to eigenstrain distribu- tions throughout the inclusion and to the anisotropy of elastic media for matrices. -2- When eigenstrains are of a...introduce any stress field. It is called an impotent inclusion. Such an inclusion exists when an eigenstrain is a gradient of a function which vanishes...Appl. Mech. 44, 591-594 (1977). T. Mura, " Eigenstrains in Lattice Theory," Continuum Models in Discrete Systems, Proc. 2nd Int. Conf., Mont Gabriel

Optimal Mass Transport for Statistical Estimation, Image Analysis, Information Geometry, and Control

DTIC Science & Technology

2017-01-10

Metric Uncertainty for Spectral Estimation based on Nevanlinna-Pick Interpolation, (with J. Karlsson) Intern. Symp. on the Math . Theory of Networks and...Systems, Melbourne 2012. 22. Geometric tools for the estimation of structured covariances, (with L. Ning, X. Jiang) Intern. Symposium on the Math . Theory...estimation and the reversibility of stochastic processes, (with Y. Chen, J. Karlsson) Proc. Int. Symp. on Math . Theory of Networks and Syst., July

Handheld Synthetic Array Final Report, Part B

DTIC Science & Technology

2014-12-01

Multiple Model IMU Inertial Measurement Unit 4/154 IEEE Institute of Electrical and Electronics Engineers KF Kalman Filter KL Kullback - Leibler LAMBDA...important metric in information theory is the input–output mutual information (MI) that is used as an indicator of how much coded information can be...tracking using best- fitting Gaussian distributions,” Proc. Int. Conf. Inform . Fusion, pp. 1–8, 2005. [liv] L. Svensson, “On the Bayesian Cramér-Rao

Two-Dimensional Signal Processing, Optical Information Storage and Processing, and Electromagnetic Measurements

DTIC Science & Technology

1992-07-15

Modeling SENIOR PRINCIPAL INVESTIGATOR: R. M. Mersereau, Regents’ Professor SCIENTIFIC PERSONNEL: F. J. Malassenet, (Ph.D. received, Dec. 1991) T. R. Gardos ...multiprocessor environment. RESEARCH ACCOMPLISHMENTS: Students Gardos , Martucci, Rao, and Truong were partially supported using funds supplied by Georgia...pp. 21- 56, 1991. [4] T. R. Gardos and R. M. Mersereau, "FIR Filtering on a Lattice with Periodically Deleted Samples," Proc. 1991 IEEE Int. Conf

Fractal Point Process and Queueing Theory and Application to Communication Networks

DTIC Science & Technology

1999-12-31

use of nonlinear dynamics and chaos in the design of innovative analog error-protection codes for com- munications applications. In the chaos...the fol- lowing theses, patent, and papers. 1. A. Narula, M. D. Trott , and G. W. Wornell, "Information-Theoretic Analysis of Multiple-Antenna...Bounds," in Proc. Int. Conf. Dec. Control, (Japan), Dec. 1996. 5. G. W. Wornell and M. D. Trott , "Efficient Signal Processing Tech- niques for

A gravitational potential finding for rotating cosmological body in the context of proto-planetary dynamics problem solving

NASA Astrophysics Data System (ADS)

Krot, Alexander M.

2008-09-01

The statistical theory for a cosmological body forming (so-called the spheroidal body model) has been proposed in [1]-[9]. Within the framework of this theory, bodies have fuzzy outlines and are represented by means of spheroidal forms [1],[2]. In the work [3], it has been investigated a slowly evolving in time process of a gravitational compression of a spheroidal body close to an unstable equilibrium state. In the papers [4],[5], the equation of motion of particles inside the weakly gravitating spheroidal body modeled by means of an ideal liquid has been obtained. Using Schwarzschild's and Kerr's metrics a consistency of the proposed statistical model with the general relativity has been shown in [6]. The proposed theory follows from the conception for forming a spheroidal body from protoplanetary nebula [7],[8]; it permits to derive the form of distribution functions for an immovable [1]-[5] and rotating spheroidal body [6]-[8] as well as their density masses and also the distribution function of specific angular momentum of the rotating uniformly spheroidal body [7],[8]. It is well-known there is not a statistical equilibrium in a gas-dust proto-planetary cloud because of long relaxation time for proto-planets formation in own gravitational field. This proto-planetary system behavior can be described by Jeans' equation in partial derivations relative to a distribution function [9]. The problem for finding a general solution of Jeans' equation is connected directly with an analytical expression for potential of gravitational field. Thus, the determination of gravitational potential is the main problem of statistical dynamics for proto-planetary system [9]. This work shows this task of proto-planetary dynamics can be solved on the basis of spheroidal bodies theory. The proposed theory permits to derive the form of gravitational potential for a rotating spheroidal body at a long distance from its center. Using the obtained analytical expression for potential of gravitational field, the gravitational strength (as well as angular momentum space function) in a remote zone of a slowly gravitational compressed rotating spheroidal body is obtained. As a result, a distribution function describing mechanical state of proto-planetary system can be found from the Jeans' equation. References: [1] Krot AM. The statistical model of gravitational interaction of particles. Uspekhi Sovremennoï Radioelektroniki (special issue "Cosmic Radiophysics", Moscow) 1996; 8: 66-81 (in Russian). [2] Krot AM. Use of the statistical model of gravity for analysis of nonhomogeneity in earth surface. Proc. SPIE's 13th Annual Intern. Symposium "AeroSense", Orlando, Florida, USA, April 5-9, 1999; 3710: 1248-1259. [3] Krot AM. Statistical description of gravitational field: a new approach. Proc. SPIE's 14th Annual Intern.Symposium "AeroSense", Orlando, Florida, USA, April 24-28, 2000; 4038: 1318-1329. [4] Krot AM. Gravidynamical equations for a weakly gravitating spheroidal body. Proc. SPIE's 15th Annual Intern. Symposium "AeroSense", Orlando, Florida, USA, April 16-20, 2001; 4394: 1271-1282. [5] Krot AM. Development of gravidynamical equations for a weakly gravitating body in the vicinity of absolute zero temperature. Proc. 53rd Intern. Astronautical Congress (IAC) - The 2nd World Space Congress-2002, Houston, Texas, USA, October 10-19, 2002; Preprint IAC-02-J.P.01: 1-11. [6] Krot AM. The statistical model of rotating and gravitating spheroidal body with the point of view of general relativity. Proc. 35th COSPAR Scientific Assembly, Paris, France, July 18-25, 2004; Abstract-Nr. COSPAR 04-A- 00162. [7] Krot A. The statistical approach to exploring formation of Solar system. Proc. European Geoscinces Union (EGU) General Assembly, Vienna, Austria, April 02-07, 2006; Geophysical Research Abstracts, vol. 8: EGU06-A- 00216, SRef-ID: 1607-7962/gra/. [8] Krot AM. The statistical model of original and evolution planets of Solar system and planetary satellities. Proc. European Planetary Science Congress, Berlin, Germany, September 18-22, 2006; Planetary Research Abstracts, ESPC2006-A-00014. [9] Krot A. On the principal difficulties and ways to their solution in the theory of gravitational condensation of infinitely distributed dust substance. Proc. XXIV IUGG General Assembly, Perugia, Italy, July 2-13, 2007; GS002 Symposium "Gravity Field", Abstract GS002-3598: 143-144.

Can dryland geoproxy data generate Quaternary palaeoclimate and palaeoenvironmental records?

NASA Astrophysics Data System (ADS)

Thomas, David S. G.

2017-04-01

Dryland regions present many challenges for robustly reconstructing late Quaternary palaeoenvironments and palaeoclimates, not least a common deficit, or considerable spatial variability, in the availability of high resolution biological proxy data sources. Substantial advances have been made in some regions in recent years, through the exploitation of new high resolution biomarker and isotope records, for example from hyrax middens (e.g. Chase et al., 2012) and from offshore sediments (e.g. Collins et al., 2014). In others however, suitable data sources for these approaches are absent, so these approaches are not available or if data are applied from distant sources, subject to risks of excessive spatial extrapolation of records in environmental contexts where environmental gradients are steep and variability is common (Thomas and Burrough, 2012, Thomas et al., 2013). In these contexts, geoproxy records, derived from the analysis of landforms and their associated sediments, are often utilised in dryland Quaternary research (e.g. Burrough and Thomas 2009, Stone and Thomas, 2013, Thomas, 2013, Lancaster et al., 2015), but with a number of associated difficulties (e.g. Chase, 2009). This paper examines these difficulties and then explores different approaches to the analysis of Quaternary landform records. It is argued that geoproxies with chronometric control, usually provided by OSL dating, have considerable potential to improve data on Quaternary environmental and climate dynamics, if records are interpreted effectively and appropriately (e.g. Bailey and Thomas, 2014, Thomas and Burrough, 2016). Examples of challenges and new approaches will be drawn from aeolian and fluvial domains, and from research in Africa, Australia and Arabia. Bailey RM, Thomas DSG 2014 Earth Surf. Proc. Landf. 39, 614-631. Burrough SL, Thomas DSG 2009. Geomorphology 103, 285-298. Chase, B 2009. Earth-Sci Rev. 93, 31-45. Chase BM et al. 2010 Quat. Sci. Rev. 56, 107-125. Collins JA et al. 2014 Earth Planet. Sci. Let. 398, 1-10. Lancaster N et al. 2016 Quat. Int. 410, 3-10. Stone AEC, Thomas DSG 2013 J. Arid Env. 93, 40-58. Thomas DSG 2013 Earth Surf. Proc. Landf. 38, 3-16. Thomas DSG, Burrough SL 2012 Quat. Int. 253, 5-17. Thomas DSG et al. 2012 J. Quat. Sci. 27, 7-12. Thomas DSG, Burrough SL 2016 Quat. Int. 410, 30-45.

Two-Dimensional Signal Processing, Optical Information Storage and Processing, and Electromagnetic Measurements

DTIC Science & Technology

1994-05-16

analysis of anisotropic grating diffraction, perfor- mance analysis of Givens rotation integrated optical interdigitated-electrode cross- channel Bragg...11. T. R. Gardos and R. M. Mersereau, "FIR filtering on a lattice with periodically deleted samples," Proc. 1991 IEEE Int. Conf. on Acoustics...pp. vol. 1, pp. 301-311, July 1992. 23. T. R. Gardos , K. Nayebi, and R. M. Mersereau, "Time domain analysis of multi- dimensional multi-rate filter

An Introduction to the IP/PCT Model Implementation in IPME

DTIC Science & Technology

2011-03-01

perceptuel (TCP) mis en œuvre dans le logiciel Environnement intégré de modélisation des performances (EIMP) par Micro Analysis and Design. Ce...de la théorie du contrôle perceptuel (TCP) mis en œuvre dans le logiciel Environnement intégré de modélisation des performances (EIMP) par Micro...modèles de traitement de l’information (TI) et de la théorie du contrôle perceptuel (TCP) mis en œuvre dans le logiciel Environnement intégré de

[Skin grafting in the treatment of hand burns sequelae in relation to 152 cases. Report from Department of Plastic Surgery, University Hospital Ibn Sina].

PubMed

El Mazouz, S; Fejjal, N; Hafidi, J; Cherkab, L; Mejjati, H; Belfqih, R; Gharib, N; Abbassi, A

2010-03-31

La main est fréquemment exposée aux brûlures, entraînant des séquelles esthétiques et fonctionnelles. Le traitement de ces séquelles est surtout chirurgical et consiste en la greffe de peau, dont le type dépend de la localisation de la brûlure et du type des séquelles. Dans ce travail rétrospectif, nous rapportons une série de 152 cas de brûlures des mains colligés au service de chirurgie plastique du Centre Hospitalier Universitaire Ibn-Sina de Rabat sur une période de dix ans, allant de 1998 à 2007. Les indications thérapeutiques dépendent du type de séquelles et de la localisation de la brûlure. En tout, 97 patients ont bénéficié d'une greffe cutanée, dont 76% par greffe de peau totale, 21% par greffe de peau demi-épaisse et 3% par peau fine. Les séquelles des brûlures des mains posent un problème thérapeutique majeur, malgré la diversité des procédés chirurgicaux, d'où l'intérêt de la prévention.

First Time Authentication for Airborne Networks (FAAN)

DTIC Science & Technology

2010-01-01

21] “An Improved Protocol for Demonstrating Possession of Discrete Logarithms and Some Generalizations”, D Chaum , J-H Evertse, J van de Graaf...System Sciences, p. 1-9, 1998. [5] D . Micciancio, The Shortest Vector in a Lattice is Hard to Approximate to within Some Constant, Proc. 39th...1999. [7] D . Micciancio and E. Petrank, Efficient and Concurrent Zero-Knowledge from any public coin HVZK protocol, Proceedings of Advances in

Modeling Nonlinear Elastic-plastic Behavior of RDX Single Crystals During Indentation

DTIC Science & Technology

2012-01-01

single crystals has also been probed using shock experiments (6, 12) and molecular dynamics simulations (12–14). RDX undergoes a polymorphic phase...Patterson, J.; Dreger, Z.; Gupta, Y. Shock-wave Induced Phase Transition in RDX Single Crystals. J. Phys. Chem. B 2007, 111, 10897–10904. 17. Bedrov, D...and Volume Compression of β - HMX and RDX . In Proc. Int. Symp. High Dynamic Pressures; Commissariat a l’Energie Atomique: Paris, 1978; pp 3–8. 24

Thermal Dissociation of Halogen Azides

DTIC Science & Technology

1994-09-01

Proc. Int. Conf. L.asers 1986. (38) Radimacher, P.; Bittner, A. J.; Schatnc. G.; Wilner, H . Chem. Ber. (43) Hcidner. R. F.; Helvajian . H .; Hollaway. J...Winker, DJ. Bernard and T.A. Seder, H -gh Power Gas Lasers, Proceedings of the SPIE, I= (1990) 543. 6. R.F. Heidner, H . Helvajian , J.S. Holloway and J.B...34Production of NF(a’A) by Dissociation of Fluorine Azide," Journal of Physical Chemistry, vol. 93, pp. 4790-4796, 1989. 3. R.H. Heidner, H . Helvajian , J.S

Process Defects in Composites.

DTIC Science & Technology

1995-01-30

mean velocity, U, a high kinematic viscosity, v , and a small diameter of the fibers, D , lead to a very small Reynolds number Re = UD << 1 (1) where p is...partial credit to ARO). 9. D . Krajcinovic and S . Mastilovic, "Damage Evolution and Failure Modes", in: Proc. of the Int. Conf. on Computational...34Computer Simulation of a Model for Irreversible Gelation", Journal of Physics A, Vol. 16., pp. 1221-1239. Kuksenko, V . S . and Tamuzs, V . P., 1981

A Domain Independent Framework for Extracting Linked Semantic Data from Tables

DTIC Science & Technology

2012-01-01

Evidence - based medicine , the essential role of systematic reviews, and the need for automated text mining tools. In: Proc. 1st ACM Int. Health... based medicine : what it is and what it isn’t. Bmj 312(7023), 71 (1996) 23. Sahoo, S.S., Halb, W., Hellmann, S., Idehen, K., Thibodeau Jr, T., Auer, S., Se...Journal of Artificial Intelligence Research 11(1), 95–130 (1999) 22. Sackett, D., Rosenberg, W., Gray, J., Haynes, R., Richardson, W.: Evidence

Application of a Design Space Exploration Tool to Enhance Interleaver Generation

DTIC Science & Technology

2009-06-24

2], originally dedicated to channel coding, are being currently reused in a large set of the whole digital communication systems (e.g. equalization... originally target interface synthesis, is shown to be also suited to the interleaver design space exploration. Our design flow can take as input...slice turbo codes,” in Proc. 3rd Int. Symp. Turbo Codes, Related Topics, Brest , 2003, pp. 343–346. [11] IEEE 802.15.3a, WPAN High Rate Alternative [12

Thermal Decomposition of Gaseous Ammonium Nitrate at Low Pressure: Kinetic Modeling of Product Formation and Heterogeneous Decomposition of Nitric Acid

NASA Astrophysics Data System (ADS)

Park, J.; Lin, M. C.

2009-10-01

The thermal decomposition of ammonium nitrate, NH4NO3 (AN), in the gas phase has been studied at 423-56 K by pyrolysis/mass spectrometry under low-pressure conditions using a Saalfeld reactor coated with boric acid. The sublimation of NH4NO3 at 423 K was proposed to produce equal amounts of NH3 and HNO3, followed by the decomposition reaction of HNO3, HNO3 + M → OH + NO2 + M (where M = third-body and reactor surface). The absolute yields of N2, N2O, H2O, and NH3, which can be unambiguously measured and quantitatively calibrated under a constant pressure at 5-6.2 torr He are kinetically modeled using the detailed [H,N,O]-mechanism established earlier for the simulation of NH3-NO2 (Park, J.; Lin, M. C. Technologies and Combustion for a Clean Environment. Proc. 4th Int. Conf. 1997, 34-1, 1-5) and ADN decomposition reactions (Park, J.; Chakraborty, D.; Lin, M. C. Proc. Combust. Inst. 1998, 27, 2351-2357). Since the homogeneous decomposition reaction of HNO3 itself was found to be too slow to account for the consumption of reactants and the formation of products, we also introduced the heterogeneous decomposition of HNO3 in our kinetic modeling. The heterogeneous decomposition rate of HNO3, HNO3 + (B2O3/SiO2) → OH + NO2 + (B2O3/SiO2), was determined by varying its rate to match the modeled result to the measured concentrations of NH3 and H2O; the rate could be represented by k2b = 7.91 × 107 exp(-12 600/T) s-1, which appears to be consistent with those reported by Johnston and co-workers (Johnston, H. S.; Foering, L.; Tao, Y.-S.; Messerly, G. H. J. Am. Chem. Soc. 1951, 73, 2319-2321) for HNO3 decomposition on glass reactors at higher temperatures. Notably, the concentration profiles of all species measured could be satisfactorily predicted by the existing [H,N,O]-mechanism with the heterogeneous initiation process.

Global Methods for Image Motion Analysis

DTIC Science & Technology

1992-10-01

a variant of the same error function as in Adiv [2]. Another related approach was presented by Maybank [46,45]. Nearly all researchers in motion...with an application to stereo vision. In Proc. 7th Intern. Joint Conference on AI, pages 674{679, Vancouver, 1981. [45] S. J. Maybank . Algorithm for...analysing optical ow based on the least-squares method. Image and Vision Computing, 4:38{42, 1986. [46] S. J. Maybank . A Theoretical Study of Optical

The kinetic equations for rotating and gravitating spheroidal body

NASA Astrophysics Data System (ADS)

Krot, A.

2003-04-01

In papers [1],[2] it has been proposed a statistical model of the gravitational interaction of particles.In the framework of this model bodies have fuzzy outlines and are represented by means of spheroidal forms. A con- sistency of the proposed statistical model the Einstein general relativity [3], [4], [5] has been shown. In work [6], which is a continuation of the paper[2], it has been investigated a slowly evolving in time process of a gravitational compression of a spheroidal body close to an unstable equilibrium state. In the paper [7] the equation of motion of particles inside the weakly gravitating spheroidal body modeled by means of an ideal liquid has been obtained. It has been derived the equations of hyperbolic type for the gravitational field of a weakly gravitating spheroidal body under observable values of velocities of particles composing it [7],[8]. This paper considers the case of gravitational compres- sion of spheroidal body with observable values of parti- cles.This means that distribution function of particles inside weakly rotating spheroidal body is a sum of an isotropic space-homogeneous stationary distribution function and its change (disturbance) under influence of dymanical gravitational field. The change of initial space-homogeneous stationary distribution function satisfyes the Boltzmann kinetic equation. This paper shows that if gravitating spheroidal body is rotating uniformly or is being at rest then distribution function of its particles satisfyes the Liouville theorem. Thus, being in unstable statistical quasiequilibrium the gravi- tating spheroidal body is rotating with constant angular velocity (or, in particular case, is being at rest). The joint distribution function of spheroidal body's particles in to coordinate space and angular velocity space is introduced. References [1] A.M.Krot, Achievements in Modern Radioelectronics, special issue "Cosmic Radiophysics",no. 8, pp.66-81, 1996 (Moscow, Russia). [2] A.M.Krot, Proc. SPIE 13th Symp."AeroSense", Orlando, Florida,USA, 5-9 April,vol. 3710, pp.1242-1259,1999. [3] L.D.Landau and E.M.Lifshitz, Classical Theory of Fields, Addison-Wesley, 1951. [4] S.Weinberg, Gravitation and Cosmology, John Wiley and Sons: New York, 1972. [5] C.W.Misner, K.S.Thorne,and J.A.Wheeler, Gravitation, W.H.Freeman and Co., San Francisco, 1973. [6] A.M.Krot, Proc. SPIE 14th Symp. "AeroSense",Orlando, Florida, USA, 24-29 April,vol.4038,pp.1318-1329,2000. [7] A.M.Krot, Proc. SPIE 15th Symp. "AeroSense",Orlando, Florida, USA, 16-20 April,vol.4394,pp.1217-1282,2001. [8] A.M.Krot, Proc. 53rd Intern. Astronautical Congress, The World Space Congress-2002, Houston, Texas, USA, 10-19 October,Preprint IAC-02-J.p.1,pp.1-11,2002.

Bioaccessibility of U, Th and Pb in particulate matter from an abandoned uranium mine

NASA Astrophysics Data System (ADS)

Millward, Geoffrey; Foulkes, Michael; Henderson, Sam; Blake, William

2016-04-01

Currently, there are approximately 150 uranium mines in Europe at various stages of either operation, development, decommissioning, restoration or abandonment (wise-uranium.com). The particulate matter comprising the mounds of waste rock and mill tailings poses a risk to human health through the inadvertent ingestion of particles contaminated with uranium and thorium, and their decay products, which exposes recipients to the dual toxicity of heavy elements and their radioactive emissions. We investigated the bioaccessibility of 238U, 232Th and 206,214,210Pb in particulate samples taken from a contaminated, abandoned uranium mine in South West England. Sampling included a mine shaft, dressing floor and waste heap, as well as soils from a field used for grazing. The contaminants were extracted using the in-vitro Unified Bioaccessibility Research Group of Europe Method (UBM) in order to mimic the digestion processes in the human stomach (STOM) and the combined stomach and gastrointestinal tract (STOM+INT). Analyses of concentrations of U, Th and Pb in the extracts were by ICP-MS and the activity concentrations of radionuclides were determined on the same particles, before and after extraction, using gamma spectroscopy. 'Total' concentrations of U, Th and Pb for all samples were in the range 57 to 16,200, 0.28 to 3.8 and 69 to 4750 mg kg-1, respectively. For U and Pb the concentrations in the STOM fraction were lower than the total and STOM+INT fractions were even lower. However, for Th the STOM+INT fractions were higher than the STOM due to the presence of Th carbonate species within the gastrointestinal fluid. Activity concentrations for 214Pb and 210Pb, including total, STOM and STOM+INT, were in the range 180 to <1 Bq g-1 for the dressing floor and waste heap and 18 to <1 Bq g-1 for the grazing land. Estimates of the bioaccessible fractions (BAFs) of 238U in the most contaminated samples were 39% and 8% in the STOM and STOM+INT, respectively, whereas the respective BAFs for 232Th were 3% and 9%. For stable 206Pb the STOM and STOM+INT BAFs were 16% and 3% for the most contaminated samples, whereas those from the field had 44% in the STOM fraction and 17% in the STOM+INT fraction. The BAFs for 214Pb and 210Pb were the same as 206Pb. Dose estimates were made for the contaminants together with radioactive doses in order to assess potential risk to human health.

A comparison of three radiation models for the calculation of nozzle arcs

NASA Astrophysics Data System (ADS)

Dixon, C. M.; Yan, J. D.; Fang, M. T. C.

2004-12-01

Three radiation models, the semi-empirical model based on net emission coefficients (Zhang et al 1987 J. Phys. D: Appl. Phys. 20 386-79), the five-band P1 model (Eby et al 1998 J. Phys. D: Appl. Phys. 31 1578-88), and the method of partial characteristics (Aubrecht and Lowke 1994 J. Phys. D: Appl.Phys. 27 2066-73, Sevast'yanenko 1979 J. Eng. Phys. 36 138-48), are used to calculate the radiation transfer in an SF6 nozzle arc. The temperature distributions computed by the three models are compared with the measurements of Leseberg and Pietsch (1981 Proc. 4th Int. Symp. on Switching Arc Phenomena (Lodz, Poland) pp 236-40) and Leseberg (1982 PhD Thesis RWTH Aachen, Germany). It has been found that all three models give similar distributions of radiation loss per unit time and volume. For arcs burning in axially dominated flow, such as arcs in nozzle flow, the semi-empirical model and the P1 model give accurate predictions when compared with experimental results. The prediction by the method of partial characteristics is poorest. The computational cost is the lowest for the semi-empirical model.

New classification of landslide-inducing anthropogenic activities

NASA Astrophysics Data System (ADS)

Michoud, C.; Jaboyedoff, M.; Derron, M.-H.; Nadim, F.; Leroi, E.

2012-04-01

Although landslides are usually considered typical examples of natural hazards, they can be influenced by human activities. Many examples can be found in the literature about slope instabilities induced by anthropogenic activities, ranging from small superficial landslides to rock avalanches. Research on this topic is of primary importance for understanding and mitigation of landslide risk. Indeed, slope stabilities influenced by human actions contribute significantly to the risk level because, by definition, they are located where elements at risk and people are present. Within the framework of the European project SafeLand "Living with Landslide Risk in Europe", the authors analyzed the landslides induced by anthropogenic factors in Europe and elsewhere (SafeLand deliverable D1.6). During the bibliographical research, it appeared that a complete and illustrated classification on human activities influencing slope stabilities does not yet exist. Therefore, a new classification was introduced by Michoud et al. (2011) about anthropogenic activities affecting slope stability conditions. This classification takes into account conceptual processes leading to landslides (Terzaghi, 1950; Jaboyedoff and Derron, 2005) and the distinction between destabilization factors and triggering factors (Vaunat et al., 1994; Leroueil et al., 1996). The classification was tested and improved through fifty-eight well-documented case studies, even lots of large landslides, such as Elm, Aberfan, Namsos and Rissa landslides, etc. Furthermore, the boundary between natural and "anthropogenic" landslide triggers (e.g. water run-off modified by new land-uses, creating landslides some km farther), and the time during which changes and reactions are to be considered as direct consequences of human activities were highlighted. Finally, anthropogenic influences can also be positive and examples of (non-voluntary) positive human impacts on slope stability are presented. Jaboyedoff, M. and Derron, M.-H. 2005. Integrated risk assessment process for landslides. In: Landslide risk management, Hungr, O., Fell, R., Couture, R. and Eberhardt, E. (eds.): 776 p. Leroueil, S., Locat, J., Vaunat, J., Picarelli, L. Lee, H. and Faure, R. 1996. Geotechnical characterization of slope movements, Landslides, Senneset (ed.), 53-73. Michoud, C., Jaboyedoff, M., Derron, M.-H., Nadim, F. and Leroi, E. 2011. Classification of landslide-inducing anthropogenic activities, 5th Canadian Conference on Geotechnique and Natural Hazards, Kelowna, Canada, 10 p. Terzaghi, K. 1950. Mechanism of Landslides, The Geological Society of America, Engineering Geology (Berkley) Volume, 83-123. Vaunat, J., Leroueil, S. and Faure, R. 1994. Slope movements: a geotechnical perspective. Proc. 7th Int. Congress of Int. Association of Engineering Geology, Oliveira (ed.), 1637-1646.

Geomagnetic inverse problem and data assimilation: a progress report

NASA Astrophysics Data System (ADS)

Aubert, Julien; Fournier, Alexandre

2013-04-01

In this presentation I will present two studies recently undertaken by our group in an effort to bring the benefits of data assimilation to the study of Earth's magnetic field and the dynamics of its liquid iron core, where the geodynamo operates. In a first part I will focus on the geomagnetic inverse problem, which attempts to recover the fluid flow in the core from the temporal variation of the magnetic field (known as the secular variation). Geomagnetic data can be downward continued from the surface of the Earth down to the core-mantle boundary, but not further below, since the core is an electrical conductor. Historically, solutions to the geomagnetic inverse problem in such a sparsely observed system were thus found only for flow immediately below the core mantle boundary. We have recently shown that combining a numerical model of the geodynamo together with magnetic observations, through the use of Kalman filtering, now allows to present solutions for flow throughout the core. In a second part, I will present synthetic tests of sequential geomagnetic data assimilation aiming at evaluating the range at which the future of the geodynamo can be predicted, and our corresponding prospects to refine the current geomagnetic predictions. Fournier, Aubert, Thébault: Inference on core surface flow from observations and 3-D dynamo modelling, Geophys. J. Int. 186, 118-136, 2011, doi: 10.1111/j.1365-246X.2011.05037.x Aubert, Fournier: Inferring internal properties of Earth's core dynamics and their evolution from surface observations and a numerical geodynamo model, Nonlinear Proc. Geoph. 18, 657-674, 2011, doi:10.5194/npg-18-657-2011 Aubert: Flow throughout the Earth's core inverted from geomagnetic observations and numerical dynamo models, Geophys. J. Int., 2012, doi: 10.1093/gji/ggs051

Propellant Nonlinear Constitutive Theory Extension: Preliminary Results.

DTIC Science & Technology

1983-08-01

Farris, R. J., Hermann , L. R., Hutchinson, J. R., and Schapery, R. A., "Development of a Solid Rocket Propellant Nonlinear Viscoelastic Constitu- tive...Publication 331, Dec. 1980. pp. 127- 133. 27. Mullins, L., "Softening of Rubber by Deformation," Rubber Chem. Technol., 1969, Vol. 31, pp. 333-362. 28. Oberth ...June 1973. 30. Hermann , L. R., and Peterson, F. E., "A Numerical Procedure for Viscoelastic Stress Analysis," Proc. 7th Mtg. of ICRPG Mech. Beh

Hydrophones for Acoustic Exploration of the Extreme Depths of the Ocean

DTIC Science & Technology

2009-09-30

For example, the system could be used to investigate the acoustic properties of hydrothermal vents, which are typically found at depths around 5000...Acoustic resonances in the bubble plume formed by a plunging water jet,” Proc. Roy. Soc. Lond. A, 459, 1751-1782 (2003) [published, refereed]. 4...Berger, "Low frequency sound from a bubble plume ", 17th International Congress on Acoustics, edited by A. Alippi, (Rome, Italy, 2-7 September 2001

Non-Destructive Measurement Methods (Neutron-, X-ray Radiography, Vibration Diagnostics and Ultrasound) in the Inspection of Helicopter Rotor Blades

DTIC Science & Technology

2005-04-01

the radiography gauging. In addition to the Statistical Energy Analysis (SEA) measurement a small exciter table (BK4810) and impedance head (BK 8000... Statistical Energy Analysis ; 7th Conf. on Vehicle System Dynamics, Identification and Anomalies (VSDIA2000), 6-8 Nov. 2000 Budapest, Proc. pp. 491-493... Energy Analysis (SEA) and Ultrasound Test. (UT) were concurrently applied. These methods collect accessory information on the objects under inspection

Magnetostatic Waves-Based Integrated Optic Bragg Cell Modules With Applications To RF Signal Processing

DTIC Science & Technology

1992-06-30

18-722, 1985. (b)N. Koshizuka, K. Ando, and T. Okuda, "Growth-Induced Birefringence in LPE - grown Iron Garnet Films ," in Proc. Int. Sy ,p...J. Martin, R. Wolf, R. C. LeCraw, and S. L. Black,"Switching and modulation of light in magneto-optic waveguides of garnet films ," Appl. Phys. Lett...in an Yttrium Iron Garnet Film ," Soy. Tech. Phys. Lett., Vol..1, pp.386-387, 1985. (c) A. A. Solomko. Yu. A. Gaidai, A. V. Dovzhenko, M. V

Joint Services Electronics Program for the Period 1 April 1990 Through 31 March 1991, (Coordinated Science Laboratory, University Illinois at Urbana-Champaign)

DTIC Science & Technology

1991-06-30

AND TITLES: 0. Arikan , Research Assistant I W. Chuang, Research Assistant A. Krone, Research Assistant M, Leung, Research Assistant I Y. Liu, Research...P. Willis and Y. Bresler, "Norm invariance of minimax-optimal interpolation," submitted to3 IEEE Trans. Inform. Theory. (JSEP/NSF) [5] 0. Arikan and...imaging of time varying distributions," in Proc. Int. Syrup. Circuits and Syst., Singapore, Jun. 1991 (to appear). (JSEP/NSF) [101 0. Arikan and 1). C

Progress Report for the Joint Services Electronics Program

DTIC Science & Technology

1989-06-30

Science L-Iaboratorv I 64 [10] 0 Arikan and D. C. Munson. Jr., "A Tomographic formulation of bistatic synthetic aperture radar," in Proc. 1988 Int. Conf...Advances in Commun Contr. Syst., vol. 1, Baton Rouge, LA, Oct. 19-21, 1988, pp 418-431. (ARO) [11] O Arikan and D C. Munson, Jr. "A new back...Angeles, CA, Jan. 15-20, 1989. (ARO) [12] C. Arikan and D. C. Munson, Jr., "Further results on a new 0(N-logN) algorithm for spotlight- mode SAR,’ in

La Greffe de Peau dans le Traitement des Sequelles de la Main Brulee. A Propos de 152 Cas - Experience du Service de Chirurgie Plastique du Centre Hospitalier Universitaire Ibn-Sina, Rabat, Maroc

PubMed Central

El Mazouz, S.; Fejjal, N.; Hafidi, J.; Cherkab, L.; Mejjati, H.; Belfqih, R.; Gharib, N.; Abbassi, A.

2010-01-01

Summary La main est fréquemment exposée aux brûlures, entraînant des séquelles esthétiques et fonctionnelles. Le traitement de ces séquelles est surtout chirurgical et consiste en la greffe de peau, dont le type dépend de la localisation de la brûlure et du type des séquelles. Dans ce travail rétrospectif, nous rapportons une série de 152 cas de brûlures des mains colligés au service de chirurgie plastique du Centre Hospitalier Universitaire Ibn-Sina de Rabat sur une période de dix ans, allant de 1998 à 2007. Les indications thérapeutiques dépendent du type de séquelles et de la localisation de la brûlure. En tout, 97 patients ont bénéficié d'une greffe cutanée, dont 76% par greffe de peau totale, 21% par greffe de peau demi-épaisse et 3% par peau fine. Les séquelles des brûlures des mains posent un problème thérapeutique majeur, malgré la diversité des procédés chirurgicaux, d'où l'intérêt de la prévention. PMID:21991196

Publications of the Division of Mechanical Engineering and the National Aeronautical Establishment. Series Number 2, Supplement Number 7.

DTIC Science & Technology

1982-01-01

1980 The Use of Heat Pipes to Control Temperature in Electronic Systems. B. Larkin, Gas Dynamics Laboratory. No. 3 - Apr. 1980 Industrial Combustor...1979. A SIMPLE LEAK-PROOF HEAT EXCHANGER FOR USE IN SOLAR ENERGY SYSTEMS, by B.S. Larkin and J. Ramsden. 14th Intersociety Energy Conversion Eng. Conf...STUDY OF THE TEMPERATURE PROFILES AND HEAT TRANSFER COEFFICIENTS IN A HEAT PIPE FOR A HEAT EXCHANGER, by B.S. Larkin. To be presented at 4th Int. Heat

Image Understanding Research and Its Application to Cartography and Computer-Based Analysis of Aerial Imagery

DTIC Science & Technology

1983-05-01

Parallel Computation that Assign Canonical Object-Based Frames of Refer- ence," Proc. 7th it. .nt. Onf. on Artifcial Intellig nce (IJCAI-81), Vol. 2...Perception of Linear Struc- ture in Imaged Data ." TN 276, Artiflci!.a Intelligence Center, SRI International, Feb. 1983. [Fram75] J.P. Frain and E.S...1983 May 1983 D C By: Martin A. Fischler, Program Director S ELECTE Principal Investigator, (415)859-5106 MAY 2 21990 Artificial Intelligence Center

Atmospheric Effects upon Laser Beam Propagation: An Annotated Bibliography

DTIC Science & Technology

1979-02-14

pp. 2711-2720, September 1978. [ Measurements in long path white cell and spietro- phone using a tunable DF laser on normal and deuterium depleted...34Backscatter in Clouds at 0.9 pm and Its Effect on Optical Fuzing Systems ," Proc. 7th Laser Conf., Vol. I1, p. 15, June 1976. [ Measured extinction and...relative transmission measurements during March at the White Sands HELSTF (High Energy Laser Standard Test 12 Facility) 6.5 km path . In May they are

Microsoft Research at TREC 2009. Web and Relevance Feedback Tracks

DTIC Science & Technology

2009-11-01

Information Processing Systems, pages 193–200, 2006. [2] J . M. Kleinberg. Authoritative sources in a hyperlinked environment. In Proc. of the 9th...Walker, S. Jones, M. Hancock-Beaulieu, and M. Gatford. Okapi at TREC-3. In Proc. of the 3rd Text REtrieval Conference, 1994. [8] J . J . Rocchio. Relevance...feedback in information retrieval. In Gerard Salton , editor, The SMART Retrieval System - Experiments in Automatic Document Processing. Prentice Hall

Fundamental Processes in Partially Ionized Plasmas

DTIC Science & Technology

1988-08-01

thermal plasma chemistry , may significantly underestimate Lie importance of radiation losses. Also shown in Figure 4 are the earlier measurements of Emmons...in Thermal Plasma Chemistry ," 8th Int’l Symposium on Plasma Chemistry , Tokyo Japan, August 1987. 4. Kruger, Charles H., "Nonequilibrium Effects in...Annual Gaseous Electronics Conference, Minneapolis, MN, October 1988. 7. Kruger, C. H., "Nonequilibrium Effects in Thermal Plasma Chemistry ," Submitted

A Cultural Resesources Overview and Reconnaissance Survey of Two Dry Reservoirs, Tazewell County, Illinois,

DTIC Science & Technology

1986-01-01

is locai-; at t - .- tl!l si , r )f the IFarm Creek Section, if th& {< 1 , 1 -, of I cut Dank o r Far r eet,, is t-. -r, -4D , raior. T1 1 sec Iea...ilar situation. in F7rmale . akinI of leavt,s Ior srove l testing will be needed to allow a ief int mv t- or I I b r.s matter -. Tnesco 7et-wns ,a wl

A condition for small bootstrap current in three-dimensional toroidal configurations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mikhailov, M. I., E-mail: mikhaylov-mi@nrcki.ru; Nührenberg, J.; Zille, R.

2016-11-15

It is shown that, if the maximum of the magnetic field strength on a magnetic surface in a threedimensional magnetic confinement configuration with stellarator symmetry constitutes a line that is orthogonal to the field lines and crosses the symmetry line, then the bootstrap current density is smaller compared to that in quasi-axisymmetric (qa) [J. Nührenberg et al., in Proc. of Joint Varenna−Lausanne Int. Workshop on Theory of Fusion Plasmas, Varenna, 1994, p. 3] and quasi-helically (qh) symmetric [J. Nührenberg and R. Zille, Phys. Lett. A 129, 113 (1988)] configurations.

Conceptual Modeling (CM) for Military Modeling and Simulation (M&S) (Modelisation conceptuelle (MC) pour la modelisation et la simulation (M&S) militaires)

DTIC Science & Technology

2012-07-01

du monde de la modélisation et de la simulation et lui fournir des directives de mise en œuvre ; et fournir des ...définition ; rapports avec les normes ; spécification de procédure de gestion de la MC ; spécification d’artefact de MC. Considérations importantes...utilisant la présente directive comme référence. • Les VV&A (vérification, validation et acceptation) des MC doivent faire partie intégrante du

The design of an ECRH system for JET-EP

NASA Astrophysics Data System (ADS)

Verhoeven, A. G. A.; Bongers, W. A.; Elzendoorn, B. S. Q.; Graswinckel, M.; Hellingman, P.; Kooijman, W.; Kruijt, O. G.; Maagdenberg, J.; Ronden, D.; Stakenborg, J.; Sterk, A. B.; Tichler, J.; Alberti, S.; Goodman, T.; Henderson, M.; Hoekzema, J. A.; Oosterbeek, J. W.; Fernandez, A.; Likin, K.; Bruschi, A.; Cirant, S.; Novak, S.; Piosczyk, B.; Thumm, M.; Bindslev, H.; Kaye, A.; Fleming, C.; Zohm, H.

2003-11-01

An electron cyclotron resonance heating (ECRH) system has been designed for JET in the framework of the JET enhanced performance project (JET-EP) under the European fusion development agreement. Due to financial constraints it has been decided not to implement this project. Nevertheless, the design work conducted from April 2000 to January 2002 shows a number of features that can be relevant in preparation of future ECRH systems, e.g. for ITER. The ECRH system was foreseen to comprise six gyrotrons, 1 MW each, in order to deliver 5 MW into the plasma (Verhoeven A.G.A. et al 2001 The ECRH system for JET 26th Int. Conf. on Infrared and Millimeter Waves (Toulouse, 10 14 September 2001) p 83; Verhoeven A.G.A. et al 2003 The 113 GHz ECRH system for JET Proc. 12th Joint Workshop on ECE and ECRH (13 16 May 2002) ed G. Giruzzi (Aix-en-Provence: World Scientific) pp 511 16). The main aim was to enable the control of neo-classical tearing modes. The paper will concentrate on: the power-supply and modulation system, including series IGBT switches, to enable independent control of each gyrotron and an all-solid-state body power supply to stabilize the gyrotron output power and to enable fast modulations up to 10 kHz and a plug-in launcher that is steerable in both toroidal and poloidal angles and able to handle eight separate mm-wave beams. Four steerable launching mirrors were foreseen to handle two mm-wave beams each. Water cooling of all the mirrors was a particularly ITER-relevant feature.

A Lightweight Intelligent Virtual Cinematography System for Machinima Production

DTIC Science & Technology

2007-01-01

portmanteau of machine and cinema , machinima refers to the innovation of leveraging video game technology to greatly ease the creation of computer...selecting camera angles to capture the action of an a priori unknown script as aesthetically appropriate cinema . There are a number of challenges therein...Proc. of the 4th International Conf. on Autonomous Agents. Young, R.M. and Riedl, M.O. 2003. Towards an Architecture for Intelligent Control of Narrative in Interactive Virtual Worlds. In Proc. of IUI 2003.

Implementation of a Fault Tolerant Control Unit within an FPGA for Space Applications

DTIC Science & Technology

2006-12-01

Conference 2002, September 2002. [20] M. Alderighi, A. Candelori, F. Casini, S. D’Angelo, M. Mancini, A. Paccagnella, S. Pastore , G.R. Sechi, “Heavy...Luigi Carro and Ricardo Reis , “Designing and Testing Fault-Tolerant Techniques for SRAM-based FPGAs,” in Proc. 1st Conference on Computer Frontiers, pp...susceptibility,” in IEEE Proc. 12th IEEE Intl. Symposium on On-Line Testing, pp. 89-91, 2006. [45] Fernanda Lima, Luigi Carro and Ricardo Reis

Helminth-conditioned dendritic cells prime CD4+ T cells to IL-4 production in vivo.

PubMed

Connor, Lisa M; Tang, Shiau-Choot; Camberis, Mali; Le Gros, Graham; Ronchese, Franca

2014-09-15

Dendritic cells (DC) are critical for the initiation of immune responses; however, their role in priming IL-4-producing Th2 cells in vivo is not fully understood. We used a model of intradermal injection with fluorescent-labeled, nonviable larvae from the helminth parasite nonviable Nippostrongylus brasiliensis L3 larvae (Nb), a strong inducer of Th2 responses, together with IL-4-GFP reporter mice that enable a sensitive detection of IL-4 production to examine the contribution of DC to the priming of IL-4-producing CD4(+) T cells in vivo. We found that parasite material is taken up by two distinct DC populations in draining lymph nodes: a mostly CD11c(int)MHC class II (MHCII)(hi)CD11b(+)Ly6C(-) dermal DC population and a CD11c(hi)MHCII(int)CD11b(+)Ly6C(+) monocyte-derived DC population. After Nb treatment, these two DC populations appeared in the draining lymph nodes in comparable numbers and with similar kinetics; however, treatment with pertussis toxin blocked the migration of dermal DC and the priming of IL-4-producing T cells, but only partially affected monocyte-derived DC numbers. In line with this observation, transfer of OVA-loaded CD11c(int)MHCII(hi) DC from Nb-treated mice into naive hosts could sensitize OVA-specific CD4(+) T cells to IL-4 production, whereas transfer of CD11c(int)MHCII(hi) DC from naive mice, or CD11c(hi)MHCII(int) DC from Nb-treated or naive mice, induced CD4(+) T cell expansion but no IL-4 production. Phenotypic analysis of Nb-loaded CD11c(int)MHCII(hi) DC revealed expression of programmed death ligand 2, CD301b, IFN regulatory factor 4, and moderate upregulation of OX40 ligand. However, thymic stromal lymphopoietin and OX40 ligand were not required for Th2 priming. Thus, our data suggest that appropriate stimuli can induce DC to express the unique signals sufficient to direct CD4(+) T cells to Th2 differentiation. Copyright © 2014 by The American Association of Immunologists, Inc.

NVR-BIP: Nuclear Vector Replacement using Binary Integer Programming for NMR Structure-Based Assignments.

PubMed

Apaydin, Mehmet Serkan; Çatay, Bülent; Patrick, Nicholas; Donald, Bruce R

2011-05-01

Nuclear magnetic resonance (NMR) spectroscopy is an important experimental technique that allows one to study protein structure and dynamics in solution. An important bottleneck in NMR protein structure determination is the assignment of NMR peaks to the corresponding nuclei. Structure-based assignment (SBA) aims to solve this problem with the help of a template protein which is homologous to the target and has applications in the study of structure-activity relationship, protein-protein and protein-ligand interactions. We formulate SBA as a linear assignment problem with additional nuclear overhauser effect constraints, which can be solved within nuclear vector replacement's (NVR) framework (Langmead, C., Yan, A., Lilien, R., Wang, L. and Donald, B. (2003) A Polynomial-Time Nuclear Vector Replacement Algorithm for Automated NMR Resonance Assignments. Proc. the 7th Annual Int. Conf. Research in Computational Molecular Biology (RECOMB) , Berlin, Germany, April 10-13, pp. 176-187. ACM Press, New York, NY. J. Comp. Bio. , (2004), 11, pp. 277-298; Langmead, C. and Donald, B. (2004) An expectation/maximization nuclear vector replacement algorithm for automated NMR resonance assignments. J. Biomol. NMR , 29, 111-138). Our approach uses NVR's scoring function and data types and also gives the option of using CH and NH residual dipolar coupling (RDCs), instead of NH RDCs which NVR requires. We test our technique on NVR's data set as well as on four new proteins. Our results are comparable to NVR's assignment accuracy on NVR's test set, but higher on novel proteins. Our approach allows partial assignments. It is also complete and can return the optimum as well as near-optimum assignments. Furthermore, it allows us to analyze the information content of each data type and is easily extendable to accept new forms of input data, such as additional RDCs.

Solid-state experiments at high pressure and strain rates

NASA Astrophysics Data System (ADS)

Kalantar, D. H.

1999-11-01

We are developing experiments on intense laser facilities to study shock compressed metal foils in the solid state. At high pressure, Rayleigh-Taylor induced perturbation growth can be reduced by the strength of the material. [1] We use this to characterize the strength of the metal foils accelerated at high pressure in the solid state. In our experiments, Al and Cu foils are compressed and accelerated with staged shocks using a temporally shaped x-ray drive that is generated in a Nova laser hohlraum target. [2] The peak pressures exceed 1 Mbar (100 GPa), and strain rates are very high, 10^7-10^9 s-1. The instability growth is observed by x-ray radiography. To probe the state of the material under compression and to demonstrate that it remains solid, we are using the dynamic Bragg diffraction technique. [3] This technique has been demonstrated on the Nova laser [4] using Si crystals shocked to 200-500 kbar. Additionally, we have observed diffraction from Cu crystals that are shocked to 100-200 kbar by direct laser irradiation on the Trident and OMEGA lasers. Compressions of up to a 10in the crystal lattice spacing have been observed. We will present the results of our work to develop these high pressure solid-state hydrodynamics experiments. 1. J. F. Barnes et al, J. Appl. Phys. 45, 727 (1974); A. I. Lebedev et al , Proc. 4th IWPCTM, 29 March-1 April, 1993, p. 81. 2. D. H. Kalantar et al., to appear in Int. J. of Impact Eng. (1999). 3. R. R. Whitlock and J. S. Wark, Phys. Rev. B 52, 8 (1995). 4. D. H. Kalantar et al, Rev. Sci. Instrum. 70, 629 (1999).

Malaria Vaccine Study Site in Irian Jaya, Indonesia: Plasmodium Falciparum Incidence Measurements and Epidemiologic Considerations in Sample Size Estimation

DTIC Science & Technology

1994-01-01

an’iiel andve hwVr miiinonimmn duhs, Th- %%I 1 7 e d the rro lralJ 1!%-irncd.m lc it, u- I "n’. ea- L’s-’. E - didateJ vacin utp~ ntiltder ~inte (ian’r...start alence of Plaitasdiwn fidkipartom among six of aplaebo-ontolld vacin stdy. ncead-populations with limited histories of exposure toa plceb

Recent Naval Postgraduate School Publications.

DTIC Science & Technology

1984-06-01

Toward a system of inquiry or organizational culture western Acad. of Manage., Colorado Springs, Colo., Apr., 1982. 1 yons, Nt ContinuouE time management...1 S 81) . Schneidewind, N F *Disciplined ap proachto real - time software design: A lock at several caEe studies (Panel session chairman)7 5th Int... Systems Res. Center, New York, Aug., 1981. Lewis, P A W Simple time series with exg.nential, gamma and hyperex cnential marginal uistributions IBM

Proceedings of the Army Science Conference (15th) Held in West Point, New York on June 17-19, 1986. Volume 4. Principal Authors S through Z,

DTIC Science & Technology

1986-06-20

See Melius, Carl F. 11 25 % % Dalrymple, Joel M. Evaluation of a Pecombinant 1 249 Morrill, John C. Vaccinia Virus Vaccine Candidate -." *" Smi...8217c, phenomenoni involves 0:_c or ..:curc corona , Do-ints that7. are operLateu at a 11 ii DC: volte .4t rcs; cct Lo .ouriu. Thie corona points \

3 CFR 8397 - Proclamation 8397 of July 23, 2009. 35th Anniversary of the Legal Services Corporation, 2009

Code of Federal Regulations, 2010 CFR

2010-01-01

... years during which the LSC has moved our Nation and our legal system towards greater equality. The LSC... of the Legal Services Corporation, 2009 8397 Proclamation 8397 Presidential Documents Proclamations Proclamation 8397 of July 23, 2009 Proc. 8397 35th Anniversary of the Legal Services Corporation, 2009By the...

3 CFR 8613 - Proclamation 8613 of December 6, 2010. 50th Anniversary of the Arctic National Wildlife Refuge

Code of Federal Regulations, 2011 CFR

2011-01-01

... Anniversary of the Arctic National Wildlife Refuge 8613 Proclamation 8613 Presidential Documents Proclamations Proclamation 8613 of December 6, 2010 Proc. 8613 50th Anniversary of the Arctic National Wildlife RefugeBy the... anniversary of the establishment of the Arctic National Wildlife Refuge, we remember that this breathtaking...

Anisotropy and Microstructure of High Coercivity Rare Earth Iron Permanent Magnets, List of Papers Published

DTIC Science & Technology

1989-01-01

EARTH IRON PERMANENT MAGNETS. LIST OF PAPERS PUBLISHED 1986 - 1989 Contract No.: DAJA45-86-C-0010 Report No.: R/D-5295-MS-01 NOV 0 � A = LIST OF...R.Gr~ssinger - ’-Does a Co substitution really improve the temperature dependence of Nd-Fe-B based permanent magnets" .’ Proc. of 91h Int. Workshop...in NdzFe,4-4-iZx B (Z=A1,Si,Co, Ga) compounds", J. de Physique 49 (1988) CS-599. (16) R.Gr8ssinger, R.Krewenka, H.Buchn~r, H.Harada " A new analysis of

3 CFR 8546 - Proclamation 8546 of August 13, 2010. 75th Anniversary of the Social Security Act

Code of Federal Regulations, 2011 CFR

2011-01-01

... Anniversary of the Social Security Act 8546 Proclamation 8546 Presidential Documents Proclamations Proclamation 8546 of August 13, 2010 Proc. 8546 75th Anniversary of the Social Security ActBy the President of... into law the Social Security Act to protect ordinary Americans “against the loss of a job and against...

Proceedings of the Annual Conference on Manual Control (15th) held March 20 - 22, 1979, Wright State University, Dayton, Ohio

DTIC Science & Technology

1979-11-01

Performance in a Precognitive Tracking Task," Proc. 13th Annual Conf. on Manual Control, pp. 152-165, June 1977. (32] Repa Brian S. and Robert S. Zucker...operators that have received attention in manual control. Precognitive manual control displays differ from the pursuit and compensatory displays of the

Analysis of Energy Resources and Programs of the Soviet Union and Eastern Europe. Appendix B. Coal

DTIC Science & Technology

1973-12-01

large ooaWlred electric po.or plant a major rail and river ^tion „1th rail and river connections to the Sea of Aaov and the Black Sea. the Caspian ...8217^ y 0r American coal deposits. The basi. _ _ ^ me oasic assumption * V. V. Strl8hkov,Coal industry of the nsmv Columbia UniversII771^^7...8217 ’K < ’ IISHCH loin T’l» • I’M 1 Is ciipnhl,, .,(• pro.lnc oT •’) me tern , • Rotnry excnvntora wi (h proc meters/hr

Les Cicatrices Retractiles Post-Brulures Du Membre Inferieur Chez L’Enfant

PubMed Central

Sankale, A.A.; Manyacka Ma Nyemb, P.; Coulibaly, N.F.; Ndiaye, A.; Ndoye, M.

2010-01-01

Summary Il s'agit d'une étude faisant ressortir les aspects épidémiologiques, cliniques et thérapeutiques des séquelles de brûlures du membre inférieur chez l'enfant, à propos de 42 cas colligés au service de chirurgie infantile de l'Hôpital Aristide Le Dantec (Sénégal). L'âge moyen retrouvé est de 5 ans et 3 mois, et le sex-ratio garçons/filles de 1,8/1. La brûlure thermique est causée par une flamme dans 33% des cas, par un liquide chaud dans 21% des cas, et par des braises dans 21% des cas. Les cicatrices rétractiles intéressent le genou et le creux poplité dans 47% des cas et le pied dans 45% des cas. Elles sont bilatérales dans 21% des cas, et concernent une autre localisation associée dans 21% des cas. Quant aux brides, 21% ont bénéficié d'une chirurgie, avec un délai moyen de 3 ans et 2 mois après la brûlure. Cette procédure chirurgicale consiste en une plastie en Z dans 91% des cas, à laquelle est associée une greffe de peau dans 54% des cas. Une rééducation fonctionnelle est pratiquée chez 54% des opérés. Parallèlement aux données de la littérature, nos résultats montrent que l'optimisation de la prise en charge passe par une meilleure prévention des accidents domestiques et une bonne codification thérapeutique. PMID:21991202

[Chemotherapy-induced diarrhea].

PubMed

Kobayashi, Kunihiko

2003-06-01

Chemotherapy-induced diarrhea is a well-documented side effect of many cancer treatments and is associated with increased morbidity and mortality. Chemotherapy-induced diarrhea negatively impacts patient quality of life and treatment outcome by requiring dose limitations or treatment interruption. The chemotherapeutic agent CPT-11 (irinotecan) has shown promising results as a single agent and in combination chemotherapy for the treatment of colorectal and small cell lung cancer. However, delayed onset diarrhea is considered to be its major dose-limiting toxicity. In some cases, it can be life threatening. To prevent CPT-11-induced delayed diarrhea, oral alkalization (OA) and control of defecation (CD) [Int J Cancer 92: 269-275, 2001] were developed based on fundamental studies [Int J Cancer 83: 491-496, 1999; Cancer Res 62: 179-187, 2002]. Oral administration of antibiotics [Cancer Res 56: 3752-3757, 1996; Clin Cancer Res 7: 1136-1141, 2001] or kampo medicine [Jpn J Cancer Res 86: 978-984, 1995; Jpn J Cancer Res 86: 985-989, 1995] to decrease beta-glucuronidase activity derived from bacteria in the large intestine was also reported to be successful in preventing delayed diarrhea. When CPT-11-induced delayed diarrhea occurs, the conventional treatment is loperamide [J Natl Cancer Inst 86: 446-449, 1994], and the early recognition and treatment of diarrhea with this opioid has reduced, although not entirely eliminated, patient morbidity. Other therapies are needed to treat patients with loperamide-refractory CPT-11 induced diarrhea, and the successful use of the somatostatin analogue octreotide has been reported [Support Care Cancer 9: 258-260, 2001; Ann Oncol 12: 227-229, 2001; Proc Am Soc Clin Oncol 21: 387a, 2002].

Electromagnetic field effects in explosives

NASA Astrophysics Data System (ADS)

Tasker, Douglas

2009-06-01

Present and previous research on the effects of electromagnetic fields on the initiation and detonation of explosives and the electromagnetic properties of explosives are reviewed. Among the topics related to detonating explosives are: measurements of conductivity; enhancement of performance; and control of initiation and growth of reaction. Hayes...()^1 showed a strong correlation of peak electrical conductivity with carbon content of the detonation products. Ershov.......^2 linked detailed electrical conductivity measurements with reaction kinetics and this work was extended to enhance detonation performance electrically;...^3 for this, electrical power densities of the order of 100 TW/m^2 of explosive surface normal to the detonation front were required. However, small electrical powers are required to affect the initiation and growth of reaction.......^4,5 A continuation of this work will be reported. LA-UR 09-00873 .^1 B. Hayes, Procs. of 4th Symposium (International) on Detonation (1965), p. 595. ^2 A. Ershov, P. Zubkov, and L. Luk'yanchikov, Combustion, Explosion, and Shock Waves 10, 776-782 (1974). ^3 M. Cowperthwaite, Procs. 9th Detonation Symposium (1989), p. 388-395. ^4 M. A. Cook and T. Z. Gwyther, ``Influence of Electric Fields on Shock to Detonation Transition,'' (1965). ^5 D. Salisbury, R. Winter, and L. Biddle, Procs. of the APS Topical Conference on Shock Compression of Condensed Matter (2005) p. 1010-1013.

Internal waves in sheared flows: Lower bound of the vorticity growth and propagation discontinuities in the parameter space

NASA Astrophysics Data System (ADS)

Fraternale, Federico; Domenicale, Loris; Staffilani, Gigliola; Tordella, Daniela

2018-06-01

This study provides sufficient conditions for the temporal monotonic decay of enstrophy for two-dimensional perturbations traveling in the incompressible, viscous, plane Poiseuille, and Couette flows. Extension of Synge's procedure [J. L. Synge, Proc. Fifth Int. Congress Appl. Mech. 2, 326 (1938); Semicentenn. Publ. Am. Math. Soc. 2, 227 (1938)] to the initial-value problem allow us to find the region of the wave-number-Reynolds-number map where the enstrophy of any initial disturbance cannot grow. This region is wider than that of the kinetic energy. We also show that the parameter space is split into two regions with clearly distinct propagation and dispersion properties.

Détection homodyne pour mémoires holographiques à stockage bit à bit

NASA Astrophysics Data System (ADS)

Maire, G.; Pauliat, G.; Roosen, G.

2006-10-01

Les mémoires holographiques à stockage bit à bit sont une alternative intéressante à l'approche holographique conventionnelle par pages de données du fait de leur architecture optique simplifiée. Nous proposons et validons ici une procédure de lecture adaptée à de telles mémoires et basée sur une détection homodyne de l'amplitude diffractée par les hologrammes. Ceci permet d'augmenter la quantité de signal utile détecté et s'avère donc prometteur pour accroître le taux de transfert de données de ces mémoires.

Longitudinal Model Building Using Latent Transition Analysis: An Example Using School Bullying Data.

PubMed

Ryoo, Ji Hoon; Wang, Cixin; Swearer, Susan M; Hull, Michael; Shi, Dingjing

2018-01-01

Applications of latent transition analysis (LTA) have emerged since the early 1990s, with numerous scientific findings being published in many areas, including social and behavioral sciences, education, and public health. Although LTA is effective as a statistical analytic tool for a person-centered model using longitudinal data, model building in LTA has often been subjective and confusing for applied researchers. To fill this gap in the literature, we review the components of LTA, recommend a framework of fitting LTA, and summarize what acceptable model evaluation tools should be used in practice. The proposed framework of fitting LTA consists of six steps depicted in Figure 1 from step 0 (exploring data) to step 5 (fitting distal variables). We also illustrate the framework of fitting LTA with data on concerns about school bullying from a sample of 1,180 students ranging from 5th to 9th grade (mean age = 12.2 years, SD = 1.29 years at Time 1) over three semesters. We identified four groups of students with distinct patterns of bullying concerns, and found that their concerns about bullying decreased and narrowed to specific concerns about rumors, gossip, and social exclusion over time. The data and command (syntax) files needed for reproducing the results using SAS PROC LCA and PROC LTA (Version 1.3.2) (2015) and Mplus 7.4 (Muthén and Muthén, 1998-2015) are provided as online supplementary materials.

3 CFR 8533 - Proclamation 8533 of June 10, 2010. 90th Anniversary of the Department of Labor Women’s Bureau, 2010

Code of Federal Regulations, 2011 CFR

2011-01-01

... the enduring vision of the Women’s Bureau and work to support all wage-earning women. With the hard... Proclamations Proclamation 8533 of June 10, 2010 Proc. 8533 90th Anniversary of the Department of Labor Women’s..., American women have played a vital role in the growth and vitality of our Nation’s economy. They have...

High Strength Steel Weldment Reliability: Weld Metal Hydrogen Trapping.

DTIC Science & Technology

1998-02-01

Reliability : Weld Metal Hydrogen Trapping submitted to : United States Army Research Office Materials Science Division P.O. Box 12211 Research Triangle...Conf. Proc. of Welding and Related Technologies for the XXIth Century, November 1998, Kiev, Ukraine : "Hydrogen Assisted Cracking in...appendices (see appendix IV). Next TTCP workshop will be held from 6th to 8th October 1998, at CANMET , Ottawa, Ontario, Canada. 20 III. Figures 18

Noise, fluctuation, and HADAMARD-transform spectrometry

NASA Astrophysics Data System (ADS)

Nitzsche, Guenter; Riesenberg, Rainer

2003-05-01

The HADAMARD principle is known in optics as a multiplex technique. It describes the mode with the most advantageous increase of the signal-to-noise ratio (SNR) in terms of scanning (Fellget advantage). The maximum increase of SNR, we call it gain, is (n+1)/(2On), where n is the number of multiplexing. It is valid in the case of pure detector noise. The multiplex encoding Hadamard pattern in case of n = 7 is 1110100, whereby 1 stands for a switched on channel performed by a field selector. The signals of all (switched on) channels are detected by a single detector. n measurement steps with a cyclic change of the pattern is necessary to perform the Hadamard transformation and to get the result of each individual channel. In case of n = 7 the theoretical gain is 1.51. For all possible multiplex pattern (1100000, 1110000 and so on) the gain is theoretically investigated. A multiplexing advantage (gain > 1) is reached only by the Hadamard pattern, the inverse Hadamard pattern and for (0111111)-pattern (gain=1.08). Most of the multiplex pattern are disadvantageous. The reason for maximum gain of the HADAMARD transformation is analysed theoretically. Signal fluctuations during the measurement caused by fluctuations of the illumination or by the object under test, reduce the multiplex gain, too. So the limits for realizing a gain are estimated theoretically. Essential is the transformation procedure and its influence on the error propagation. The results could be verified by experiments with array spectrometeres. Requirements are derived by numerical simulation concerning the stability of the signals to be multiplexed. It is simulated the needed stability of the signals with increasing order of multiplexing. So the increase of the multiplex gain is limited by signal fluctuations. A realized 96 channel spectral reader is presented as a modern application of an optical multiplexing arrangement. ! M. Harvid, N. J. A. Sloane, Hadamard Transform Optics, Academic Press, 1979 ! R.A. De Verse, R.M. Hammaker, W. G. Fately, J.A.Graham, J.D.Tate, "Spectrometry and imaging using a digital micromirror array" American Laboratory, Vol. 30, 21, pp. 112-120, 1998 ! R. Riesenberg, A. Wuttig, B. Harnisch, "Optical MEMS Technology for Multiplexing in High-End Micro-Scpectrometers", Proc. SPIE 4928, 6-14, 2002 ! A. Wuttig, R. Riesenberg, "Hyperspectral imager with a facile MEMS", Proc. SPIE 4881A, 2002, to be published ! R. Riesenberg, G. Nitzsche, W. Voigt, 'HADAMARD Encoding and other optical Multiplexing', VDI-Berichte 1694, pp. 345-350, 2002 ! A. Wuttig, R. Riesenberg, G. Nitzsche, "Subpixel Analysis of Double Array Grating Spectrometer", Proc. SPIE 4480, pp. 334-344, 2002 ! A. Wuttig, R. Riesenberg, G. Nitzsche, "Integral Field and Multi Object Spectrometry with MEMS", Proc. SPIE 4480, pp. 367-376, 2002 ! R. Riesenberg, G. Nitzsche, A. Wuttig, B. Harnisch, "Micro Spectrometer and MEMS for Space" in "Smaller Satellites: Bigger Business?", edited by M. Rycroft, N. Crosby, Kluwer Academic Publisher, pp. 403-406, 2002 ! R. Riesenberg, A. Wuttig, "Optical sensors with MEMS, slit masks and micromechanical devices", Proc. SPIE 4561, pp. 315-322, 2001 ! R. Riesenberg, "MicroMechanical Slit Positioning System as a transmissive spatial Light Modulator", Proc. SPIE 4457, pp.197-203, 2001 ! R. Riesenberg, J. Lonschinski, "HADAMARD-Minispectrometer made by a Micro Device", Proc. "3rd Round Table on Micro/NanoTechnologies for Space", ESTEC, Noordwijk, The Netherlands, pp. 291 - 297, 2000 ! R. Riesenberg, U. Dillner, "HADAMARD Imaging Spectrometers", Proc. SPIE 3753, pp. 203-213, 1999 ! R. Riesenberg, Th. Seifert, "Design of spatial Light Modulator Microdevices - Micro Slit Arrays", Proc. SPIE 3680, Part One, pp. 406-414, 1999 ! R. Riesenberg, W. Voigt, J. Schoneich, "Compact Spectrometers made by Micro System Technology", Sensor 97, Proc. Vol. 2, pp. 145-150,1997

Movement of Dislocations in Quartz

DTIC Science & Technology

1992-04-01

which N mdislocations are possible, it is essentially a static process. * * Pontikise recently made the point that computer molecular dynamics (MD...34 Proc. 38th ASFC pp. 42-49, 1984. [46] Vassilis Pontikis , "Defect Dynamics Revealed," Physics World, pp. 25-28, 1990. 9

Uncooled Tunable LWIR Microbolometer

DTIC Science & Technology

2010-05-05

switches [19], micromirrors in projection displays [20], and tunable thermal detectors [21, 22], etc. In all these devices, contact must be achieved...Failure Mechanisms of the Digital Micromirror Device (DMD)”, Proc. 36th Annual Intl. Reliability Physics Symposium, Reno, NV, pp. 9-16, 1998. [33

Active Touch Sensing

DTIC Science & Technology

1981-04-01

Marvin Minsky . -36- 1. Broit, M. The Utilization of" an "Artificial Skin" sensor for the Identification of Solid Objects. Proc. 9th lnL Symp. on...Dertouzos, Ed Hardebeck, Henry Minsky , Margaret Minsky , Lisa Schostakovich, Laurel Simmons, Latanya Sweeney. Patrick Winston and most importantly

Proceedings of the Conference on the Design of Experiments in Army Research Development and Testing (27th) Held at The McKimmon Center for Continuing Education, North Carolina State University, Raleigh, North Carolina on 21-23 October 1981

DTIC Science & Technology

1982-06-01

of states and a class of cascade processes. Proc. Cambridge Phil . Soc. 47, 77-85. Foster, F. G. (1952). On Markov chains with an enumerable infinity of...states. Proc. Cambridge Phil . Soc. 48, 587-591. Foster, F. G. (1953). On the stochastic matrices associated with certain queuing processes. Ann. Math...Frawley (1973), Li and Schucany (1975), Schucany and Beckett (1976), and Hollander and Sethurann (1978). The Schucany-Frawley-Li test is based on the

The Combined Release and Radiation Effects Satellite Time History Data Base System.

DTIC Science & Technology

1994-11-30

8-3 - MASS LOCK MODE TELEMETRY Word number Minor frame 1 2 3 4 5 6 7 8 9 0 SINGLES DETI DETi DETi DETi DETi DETi DETi DiB DiA CHANO CHANi CHAN2 CHAN3... CHANO CHANi CHAN2 INTl INTl INTl INTl INT2 INT2 INT2 1 SINGLES DETi DETi DETi DETi DETi DETi DETi D2B D2A CHAN3 CHANO CHANi CHAN2 CHAN3 CHANO CHANi...INT2 INT3 INT3 INT3 INT3 INT4 INT4 2 SINGLES DETi DETi DETI DETi DETi DETI DETi D3B D3A CHAN2 CHAN3 CHANO CHANi CHAN2 CHAN3 CHANO INT4 INT4 INT5 INT5

A Fixed-point Scheme for the Numerical Construction of Magnetohydrostatic Atmospheres in Three Dimensions

NASA Astrophysics Data System (ADS)

Gilchrist, S. A.; Braun, D. C.; Barnes, G.

2016-12-01

Magnetohydrostatic models of the solar atmosphere are often based on idealized analytic solutions because the underlying equations are too difficult to solve in full generality. Numerical approaches, too, are often limited in scope and have tended to focus on the two-dimensional problem. In this article we develop a numerical method for solving the nonlinear magnetohydrostatic equations in three dimensions. Our method is a fixed-point iteration scheme that extends the method of Grad and Rubin ( Proc. 2nd Int. Conf. on Peaceful Uses of Atomic Energy 31, 190, 1958) to include a finite gravity force. We apply the method to a test case to demonstrate the method in general and our implementation in code in particular.

Some case studies of geophysical exploration of archaeological sites in Yugoslavia

NASA Astrophysics Data System (ADS)

Komatina, Snezana; Timotijevic, Zoran

1999-03-01

One of the youngest branches of environmental geophysics application is the preservation of national heritage. Numerous digital techniques developed for exploration directed to urban planning can also be applied to investigations of historic buildings. In identifying near-surface layers containing objects of previous civilizations, various sophisticated geophysical methods are used. In the paper, application of geophysics in quantification of possible problems necessary to be carried out in order to get an archaeological map of some locality is discussed [Komatina, S., 1996]. Sophisticated geophysical methods in the preservation of national heritage. Proc. of Int. Conf. Architecture and Urbanism at the turn of the Millenium, Beograd, pp. 39-44. Finally, several examples of archaeogeophysical exploration at Divostin, Bedem and Kalenic monastery localities (Serbia, Yugoslavia) are presented.

Ablation laser pour la microélectronique plastique

NASA Astrophysics Data System (ADS)

Alloncle, A.-P.; Thomas, B.; Grojo, D.; Delaporte, Ph.; Sentis, M.; Sanaur, S.; Barret, M.; Collot, Ph.

2006-12-01

La microélectronique plastique connaît un développement sans précédent dans le domaine de la recherche. Cette étude s'intéresse à l'utilisation des lasers impulsionnels pour la réalisation de composants organiques sur supports souples. Les deux aspects plus particulièrement étudiés sont d'une part la gravure de polymère pour réaliser un canal entre la source et le drain, et d'autre part le développement d'un procédéde dépôt appelé LIFT pour Laser Induced Forward Transfer. Ce dernier pourrait notamment permettre dedéposer des composés organiques non solubles.

Introduction: Unsolved Problems on Noise

NASA Astrophysics Data System (ADS)

Oriols, X.; Ciliberto, S.

2016-05-01

This paper is an introduction to the special issue of the 7th Int. Conf. on Unsolved Problems on Noise (UPoN) that took place at Casa Convalescència in Barcelona (Spain) in July 2015. The aim of the UPoN conferences is to provide a forum for researchers working on different fields of noise, fluctuations and variability, where they present their scientific problems which resist solutions. The papers of this Special Issue reflect the interdisciplinary topics (physics, biology, circuits, financial markets, psychology, technology, etc) presented at the UPoN conference. Noise is not only a hindrance to signal detection, but it is indeed a valuable source of information (not present in the signal) that help us to get a deeper understanding on how Nature works. This special issue of the 7th International Conference on Unsolved Problems on Noise (UPoN) is dedicated to Laszlo Kish in the occasion of his 60th birthday. He organized the first edition of these UPoN conferences in Szeged (Hungary) in 1996. Many of us have greatly benefited from his ‘volcanic imagination in tackling new problems from unconventional points of views’.

IL-33 expands suppressive CD11b+ Gr-1int and regulatory T cells (Treg), including ST2L+ Foxp3+ cells, and mediates Treg-dependent promotion of cardiac allograft survival

PubMed Central

Turnquist, Hēth R.; Zhao, Zhenlin; Rosborough, Brian R.; Liu, Quan; Castellaneta, Antonino; Isse, Kumiko; Wang, Zhiliang; Lang, Megan; Stolz, Donna Beer; Zheng, Xin Xiao; Demetris, A. Jake; Liew, Foo Y.; Wood, Kathryn J.; Thomson, Angus W.

2011-01-01

IL-33 administration is associated with facilitation of Th type-2 (Th2) responses and cardioprotective properties in rodent models. However, in heart transplantation, the mechanism by which IL-33, signaling through ST2L, the membrane-bound form of ST2, promotes transplant survival is unclear. We report that IL-33 administration, while facilitating Th2 responses, also increases immunoregulatory myeloid cells and CD4+ Foxp3+ regulatory T cells (Treg) in mice. IL-33 expands functional myeloid-derived suppressor cells (MDSC), -CD11b+ cells that exhibit intermediate (int) levels of Gr-1 and potent T cell suppressive function. Furthermore, IL-33 administration causes a St2-dependent expansion of suppressive CD4+ Foxp3+ Treg, including a ST2L+ population. IL-33 monotherapy following fully allogeneic mouse heart transplantation resulted in significant graft prolongation, associated with increased Th2-type responses and decreased systemic CD8+ IFN-γ+ cells. Also, despite reducing overall CD3+ cell infiltration of the graft, IL-33 administration markedly increased intragraft Foxp3+ cells. Whereas control graft recipients displayed increases in systemic CD11b+ Gr-1hi cells, IL-33-treated recipients exhibited increased CD11b+ Gr-1int cells. Enhanced ST2 expression was observed in the myocardium and endothelium of rejecting allografts, however the therapeutic effect of IL-33 required recipient St2 expression and was dependent on Treg. These findings reveal a new immunoregulatory property of IL-33. Specifically, in addition to supporting Th2 responses, IL-33 facilitates regulatory cells, particularly functional CD4+ Foxp3+ Treg that underlie IL-33-mediated cardiac allograft survival. PMID:21949025

Estimation of Electron Bernstein Emission in the TJ-II Stellarator

NASA Astrophysics Data System (ADS)

García-Rega\\ Na, J. M.; Cappa, A.; Castejón, F.; Tereshchenko, M.

2009-05-01

In order to study experimentally the viability of first harmonic EBW heating in the TJ-II stellarator by means of the O-X-B tecnique [1], an EBE diagnostic was recently installed [2]. In the present work a theoretical estimation of the EBW radiation in the TJ-II plasmas have been carried out making use of the ray tracing code TRUBA [3]. The line of sight of the EBE diagnostic may be modified using an internal movable mirror and therefore, for comparison with the experimental results, the theoretical O-X-B emission window has been determined. Experimental density and temperature profiles obtained in NBI discharges are considered in the simulations.References:[1] F. Castejon et al, Nucl. Fusion 48, 075011 (2008).[2] J. Caughman et al, Proc. 15th Joint Workshop on ECE and ECRH, Yosemite, USA (2008).[3] M. A. Tereshchenko et. al, Proc. 30th EPS Conference on Contr. Fusion and Plasma Phys., 27A, P-1.18 (2003).

Middle school-aged child enjoyment of food tastings predicts interest in nutrition education on osteoporosis prevention

PubMed Central

Cheng, Feon W.; Monnat, Shannon M.; Lohse, Barbara

2015-01-01

BACKGROUND NEEDs for Bones (NFB), based on the Health Belief Model, is a 4-lesson osteoporosis-prevention curriculum for 11-14 year-olds. This study examined the relationship between enjoyment of food tastings and interest in NFB. METHODS NFB was administered by teachers as part of standard practice and evaluated after the 4th lesson using a 21-item survey. Significant clustering of students within classrooms required use of random-intercept multilevel ordinal regression models in SAS proc GLIMMIX, with students nested within classrooms. Analyses considered tasting experience, eating attitudes, sex, grade, and cohort. RESULTS Students (N = 1619; 50% girls) participated from 85 4th-8th grade classrooms (47% 6th grade; 31% 7th grade) in 16 Pennsylvania SNAP-Ed eligible schools over 2 academic years. For all foods tasted, students who did not enjoy the food tasting were less interested in the lesson than students who did enjoy the food tasting (all p < .001); refried beans (OR 0.30), soy milk (OR = 0.55), cranapple juice (OR = 0.51), sunflower kernels (OR = 0.48), and Swiss cheese (OR = 0.49). CONCLUSIONS Enjoyment of food tasting activities can predict interest in nutrition education on osteoporosis prevention, supporting resource allocation and inclusion of food tasting activities in school-age nutrition education. PMID:26032277

Theme section for 36th International Symposium for Remote Sensing of the Environment in Berlin

NASA Astrophysics Data System (ADS)

Trinder, John; Waske, Björn

2016-09-01

The International Symposium for Remote Sensing of the Environment (ISRSE) is the longest series of international conferences held on the topic of Remote Sensing, commencing in Ann Arbor, Michigan USA in 1962. While the name of the conference has changed over the years, it is regularly held approximately every 2 years and continues to be one of the leading international conferences on remote sensing. The latest of these conferences, the 36th ISRSE, was held in Berlin, Germany from 11 to 15 May 2015. All complete papers from the conference are available in the ISPRS International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences at http://www.int-arch-photogramm-remote-sens-spatial-inf-sci.net/XL-7-W3/index.html.

Preparation of Stable Photopatternable Polymeric Materials for Non- linear Optics

DTIC Science & Technology

1993-05-01

Scheme 3 OC 2)2-, .~(CH 2)2O N"I ~ NI H IH NCO dibutyltin-0 6a + OCN dilaurateD, DMF 0 0a r - 0 0 -N)K 0(CH22,,(H)OAN I Id H IHo=s= o NCO0n 6b + OC...Angerer, V. Desobry, K. Dietliker, R . Husler ; Proc. 16th Inter. Cont. in Ort nic Coatings Science and Technology, (July 9-13, 1990) Athens, Greece, 423. 7 ...AD-A265 359 O AGMB N.’ 0704-0Orpq 1. AGEN My1,993 3. REPORT TYPE AND OATES COVERED May12 T99 Technical Re port # IQ. 4. TITLE AND SUBTITLE 5. FUNDING

Study of the Effect of Free-Stream Turbulence upon Disturbances in the Pre-Transitional Laminar Boundary Layer. Part I. Laminar Boundary Layer Distortion by Surface Roughness; Effect upon Stability. Part II.

DTIC Science & Technology

1982-04-01

Boundary Layer Near a Plate." NACA Rept. 562, 1936. 5) A. A. Hall and G. S. Hislop , "Experiments on the Transition of the Laminar Boundary Layer on a...Cylinder." Proc. 5th Inter. Congr. Appl. Math, 1938. 7) G. S. Hislop , "The Transition of a Laminar Boundary Layer in a Wind Tunnel." Ph.D. Thesis...Small Vertical Cylinder Attached to a Flat Plate", h Fa- Elul"s, Vol. 23, Part 1, pp. 221-223, Jan. 1980 . 9. A. Von Doenhoff and E. A. Horton, "A Low

Jahn-Teller effect on the [TiF 4F 4F int] 6-(C 4v) and [NiF 4F 4F int] 7-(C 4v) clusters embedded into SrF 2 crystals

NASA Astrophysics Data System (ADS)

Ulanov, V. A.; Zhiteitcev, E. R.; Varlamov, A. G.

2007-07-01

By means of EPR method the associative [TiF 4F 4F int] 6-(C 4v) and [NiF 4F 4F int] 7-(C 4v) centers were revealed in the fluorite type SrF 2:Ti and SrF 2:Ni crystals grown by Bridgman method in helium atmosphere containing some amount of a fluorine gas. It was found that at low temperatures the local structures of these associative centers were exposed to a static rhombic distortion. The reasons of such distortions were accounted for by the assumption that the E ⊗ ( b1 + b2) vibronic interaction became effective due to that the ground orbital states of the [TiF 4F 4F int] 6-(C 4v) and [NiF 4F 4F int] 7-(C 4v) centers occurred to be doubly degenerated.

Low Temperature, Chloroaluminate Thermal Cells.

DTIC Science & Technology

1981-11-01

Thermal Batteries ", AFWAL-TR-81-2044, Aeropropulsion Laboratory, Wright-Patterson AFB, OH, June 1981. 5. J. C. Nardi, J. K. Erbacher, C. L. Hussey, and L...R. L. Vaughn, L. A. King, Proc. of the 29th Power Sources Symp, The Electrochemical Society, Princeton, NJ, June 1980. 4. D. M. Ryan, " Advanced

Important Publications in the Area of Photovoltaic Performance |

Science.gov Websites

, 2011, DOI: 978-0-12-385934-1. Photoelectrochemical Water Splitting: Standards, Experimental Methods Energy Systems Testing, Solar Energy 73, 443-467 (2002). D.R. Myers, K. Emery, and C. Gueymard, Revising Performance Evaluation Methodologies for Energy Ratings," Proc. 24th IEEE Photovoltaic Specialists Conf

Multiphase Complete Exchange: A Theoretical Analysis

DTIC Science & Technology

1993-08-01

Birkhiuser, Boston, 1984. 24 [9] C-T. Ho and M. T. Raghunath . Efficient communication primitives on hy- percubes. In Proc. 6th. DMCC, pages 390-397...1991. [10] C-T. Ho and M. T. Raghunath . Efficient communication primitives on hy- percubes. Technical Report RJ 7932 (72915), IBM, T. J. Watson Center

Physics in Europe--A Data File of Selected Research.

DTIC Science & Technology

1984-06-18

Negev Sapir Proc. 16th Euro. Conf. on Laser Interac. with Matter, London 26-30 Sept. 1983 1025 CPBICF laser plasma soft x-ray refractometry France...CPBICF laser plasma Schlieren diagnostic France 623 CPBICF laser plasma self focusing numerics UK 1025 CPBICF laser plasma soft x-ray refractometry

Two-Way Satellite Time Transfer Activities in Asian-Pacific Region

DTIC Science & Technology

1998-12-01

transfer methods for the next generation, and to investigate and to realize TWSTT network, the working group on TWSTT(presently TWSTFT ) has been... TWSTFT ) Experiment using INTELSAT Satellites at 307 Degrees East," Proc. of 27th PTTI, 1995. [6] M. Imae, H. Okazawa, T. Sato, M. Uratsuka, K

Resource-Bounded Information Gathering for Correlation Clustering

DTIC Science & Technology

2007-01-01

5], budgeted learning, [4], and active learning , for example, [3]. 3 Acknowledgments We thank Avrim Blum, Katrina Ligett, Chris Pal, Sridhar...2007 3. N. Roy, A. McCallum, Toward Optimal Active Learning through Sampling Estima- tion of Error Reduction, Proc. of 18th ICML, 2001 4. A. Kapoor, R

Runaway reactions, their courses and the methods to establish safe process conditions

NASA Astrophysics Data System (ADS)

Gustin, J. L.

1991-08-01

Much of the literature on runaway reactions deals with the consequences such as mechanical damage toxic and flammable release. The DIERS literature provides effective methods for vent sizing where experimental information is requested. Thermal stability measurements provide information on the onset temperature and kinetic data for chemical reactions. There is less information on the way the runaway reactions occur whereas the runaway reactions may have different causes. The purpose of this paper is to describe the various process deviations which can cause a runaway reaction to occur and to discuss the experimental information necessary for risk assessment, the choice of a safe process and the mitigation of the consequences of the runaway reaction. Each possible hazardous process deviation is illustrated by examples from the process industry and/or relevant experimental information obtained from laboratory experiments. The typical hazardous situations to be considered are the following: 1) The homogeneous thermal runaway due to too high a temperature. 2) The homogeneous runaway reaction by unintended introduction of additional reactants or catalyst. 3) The heterogeneous runaway reaction due to too high a local temperature. 4) The heterogeneous runaway reaction caused by slow heat conduction to the outside. 5) The runaway reaction caused by excess residence time at the process temperature (autocatalytic reactions). 6) The runaway reaction caused by reactant accumulation. The controling reactant feed rate is higher than the consumption rate perhaps because the temperature is too low, or the catalyst is absent. 7) The runaway reaction due to the pressurization of the enclosure by gaseous oxidizing intermediates (typical of nitric oxidations). 8) The runaway reaction due to phase separation of unstable species (liquids, solids) by loss of mixing or on cooling. 9) The runaway reaction on mixing of fast reacting chemicals in separate phases. 10)The runaway reaction due to fire or external heating. Considering the various runaway situations, the effectiveness of the following approaches is discussed: - Theoretical and experimental information required for hazard assessment. - Choice of adequate process conditions. - Choice of adequate methods for process control. - Experimental information required for vent sizing. La plus grande partie de la littérature sur les emballements thermiques traite des conséquences de l'accident telles que les effets mécaniques, les émissions toxiques et inflammables. Les travaux publiés par le DIERS fournissent des méthodes permettant le dimensionnement d'évents, nécessitant des déterminations expérimentales. Il y a moins d'information sur la manière dont les emballements thermiques peuvent survenir alors que ceux-ci peuvent avoir différentes causes. Le propos de cet article est de décrire les différentes dérives de procédé qui peuvent entraîner un emballement thermique et de déterminer l'information expérimentale nécessaire pour l'analyse des risques du procédé, le choix de conditions opératoires sûres et la réduction des conséquences de l'emballement thermique. Chaque dérive de procédé dangereuse, est illustrée par des exemples connus dans l'industrie chimique et par des données expérimentales obtenues dans des essais de laboratoire. Les conditions de procédé dangereuses prises en compte sont les suivantes: 1)L'emballement thermique homogène dû à une température excessive; 2) L'emballement thermique homogène par introduction d'un catalyseur ou d'un réactif contrôlant; 3) L'emballement thermique hétérogène dû à une température locale excessive; 4)L'emballement thermique hétérogène dû à une faible conduction thermique vers l'extérieur; 5) L'emballement thermique dû à un temps de séjour excessif à la température du procédé (Réactions autocatalytiques); 6) L'emballement thermique par accumulation de réactifs. La vitesse d'introduction d'un réactif contrôlant est supérieure à la vitesse de consommation de ce réactif, parce que la température est trop basse ou le catalyseur absent; 7) L'emballement thermique dû à la pressurisation d'une enceinte par des intermédiaires gazeux oxydants (situation caractéristique des oxydations nitriques), 8)L'emballement thermique dû à la séparation de phases contenant des espèces instables (liquides, solides) par perte de l'agitation ou par refroidissement; 9) L'emballement thermique par mélange de produits incompatibles, se trouvant précédemment dans des phases séparées; 10) L'emballement thermique dû à un chauffage externe ou à un feu. Considérant les différentes situations conduisant à un emballement thermique, l'intérêt de l'approche systématique suivante est examiné: - Information théorique et expérimentale nécessaire pour déterminer les risques du procédé. - Choix de conditions opératoires adéquates. - Choix de méthodes convenables pour le contrôle du procédé. - Information expérimentale nécessaire pour le calcul d'évent.

Proceedings of the Annual Symposium on Frequency Control (34th), Held 28-30 May 1980 Philadelphia, Pennsylvania

DTIC Science & Technology

1980-01-01

change between 2 x 10- 2 torr PRESSURE (to-r) and I atmosphere was measured (in a non -temper- ature controlled environment) to be less than FIGURE 8...microstrip, how- non -resonant and non -propagating. Losses due to ever, are less desirable. To control radiation finite substrate thickness werE determined .y...Temperature dependence of the stabilized oscillator. 254 Proc. 34th Ann. Freq. Control Symposium, USAERADCOM, Ft. Monmouth. NJ 07703. May 1980 NON -LINEAR

The effects of 10 weeks Integrated Neuromuscular Training on fundamental movement skills and physical self-efficacy in 6-7 year old children.

PubMed

Duncan, Michael J; Eyre, Emma L J; Oxford, Samuel W

2017-03-23

Integrated neuromuscular training (INT) has been suggested as an effective means to enhance athletic potential in children. However, few studies have reported the effects of school based INT programs. This study examined the effect of INT on process and product fundamental movement skill measures and physical self-efficacy in 6-7 year old children. Ninety-four children from 2 primary schools were randomised into either a 10 week INT program or a control group CON (n =41) group. Results indicated significantly greater increases in process FMS scores in INT vs CON (P = 0.001). For product measures of FMS, 10m sprint time, counter movement jump, seated medicine ball throw and standing long jump (all P = 0.001), all significantly increased to a greater extent in the INT group vs CON. A significant group (INT vs CON) X time (pre vs post) X gender interaction for physical self-efficacy revealed increased physical self-efficacy pre to post INT, compared to CON but only for boys (P = 0.001). For girls, physical self-efficacy was not significantly different pre to post the 10 week period for INT and CON groups. The results of this study suggest that replacing 1 of the 2 weekly statutory PE lessons with an integrated neuromuscular training programme over a 10 week period results in positive improvements in fundamental movement skill quality and outcomes in 6-7 year old children. INT also appears to increase physical self-esteem to a greater extent than statutory PE but only in boys.

Preventing weight gain in African American breast cancer survivors using smart scales and activity trackers: A randomized controlled pilot study

PubMed Central

Valle, Carmina G.; Deal, Allison M.; Tate, Deborah F.

2016-01-01

Purpose This study evaluated the feasibility and preliminary efficacy of two 6-month, self-regulation interventions that focused on daily self-weighing (DSW), and used objective monitoring and tailored feedback about weight (±activity), to prevent weight gain among African American breast cancer survivors. Methods Participants (n=35) were randomized to an intervention + activity monitoring (INT+), intervention (INT), or control (CON) group. Interventions included a wireless scale (±activity tracker) that transmitted objective data to a mobile app/website, emailed lessons, and tailored feedback based on objective weight (±activity data). Participants completed in-person and online assessments at baseline, 3 and 6 months. Results Ninety-four percent of participants completed assessments at 3 months, and 97% at 6 months. Median (IQR) weight change after 6 months was −0.9% (−4.4−0.1) in the INT+ (p=0.075; p=0.067 vs. CON) and −0.2% (−4.2−1.3) in the INT groups (p=0.463; p=0.357 vs. CON), versus a 0.2% (−0.7−1.7) gain in the CON group. The proportion of INT+, INT and CON participants that were at or below baseline weight was 72.7%, 53.8% and 45.5% respectively (effect sizes d=.64, d=.18). Most INT+ participants weighed and wore trackers ≥5 days/week (INT+, 81.9% vs. INT, 38.5% vs. CON, 0%; p< 0.0005; INT+, 72.7%). Both intervention groups perceived DSW as positive, and 100% would recommend the program to other breast cancer survivors. Conclusion An intervention focused on DSW as a self-monitoring strategy shows promise for preventing weight gain in breast cancer survivors. Implications for Cancer Survivors Daily self-monitoring of weight and activity may be a feasible and accessible approach to promote weight gain prevention in breast cancer survivors. PMID:27631874

Solar wind control of stratospheric temperatures in Jupiter's auroral regions?

NASA Astrophysics Data System (ADS)

Sinclair, James Andrew; Orton, Glenn; Kasaba, Yasumasa; Sato, Takao M.; Tao, Chihiro; Waite, J. Hunter; Cravens, Thomas; Houston, Stephen; Fletcher, Leigh; Irwin, Patrick; Greathouse, Thomas K.

2017-10-01

Auroral emissions are the process through which the interaction of a planet’s atmosphere and its external magnetosphere can be studied. Jupiter exhibits auroral emission at a multitude of wavelengths including the X-ray, ultraviolet and near-infrared. Enhanced emission of CH4 and other stratospheric hydrocarbons is also observed coincident with Jupiter’s shorter-wavelength auroral emission (e.g. Caldwell et al., 1980, Icarus 44, 667-675, Kostiuk et al., 1993, JGR 98, 18823). This indicates that auroral processes modify the thermal structure and composition of the auroral stratosphere. The exact mechanism responsible for this auroral-related heating of the stratosphere has however remained elusive (Sinclair et al., 2017a, Icarus 292, 182-207, Sinclair et al., 2017b, GRL, 44, 5345-5354). We will present an analysis of 7.8-μm images of Jupiter measured by COMICS (Cooled Mid-Infrared Camera and Spectrograph, Kataza et al., 2000, Proc. SPIE(4008), 1144-1152) on the Subaru telescope. These images were acquired on January 11th, 12th, 13th, 14th, February 4, 5th and May 17th, 18th, 19th and 20th in 2017, allowing the daily variability of Jupiter’s auroral-related stratospheric heating to be tracked. Preliminary results suggest lower stratospheric temperatures are directly forced by the solar wind dynamical pressure. The southern auroral hotspot exhibited a significant increase in brightness temperature over a 24-hour period. Over the same time period, a solar wind propagation model (Tao et al. 2005, JGR 110, A11208) predicts a strong increase in the solar wind dynamical pressure at Jupiter.

A CMOS-MEMS clamped–clamped beam displacement amplifier for resonant switch applications

NASA Astrophysics Data System (ADS)

Liu, Jia-Ren; Lu, Shih-Chuan; Tsai, Chun-Pu; Li, Wei-Chang

2018-06-01

This paper presents a micromechanical clamped–clamped beam (CC-beam) displacement amplifier based on a CMOS-MEMS fabrication process platform. In particular, a 2.0 MHz resonant displacement amplifier composed of two identical CC-beams coupled by a mechanical beam at locations where the two beams have mismatched velocities exhibits a larger displacement, up to 9.96×, on one beam than that of the other. The displacement amplification prevents unwanted input impacting—the structure switches only to the output but not the input—required by resonant switch-based mechanical circuits (Kim et al 2009 22nd IEEE Int. Conf. on Micro Electro Mechanical Systems; Lin et al 2009 15th Int. Conf. on Solid-State Sensors, Actuators, & Microsystems (TRANSDUCERS’09) Li et al 2013 17th Int. Conf. on Solid-State Sensors, Actuators, & Microsystems (TRANSDUCERS’13)). Compared to a single CC-beam displacement amplifier, theory predicts that the displacement amplifying CC-beam array yields a larger overall output displacement for displacement gain beyond 1.13 thanks to the preserved input driving force. A complete analytical model predicts the resultant stiffness and displacement gain of the coupled CC-beam displacement amplifier that match well with finite element analysis (FEA) prediction and measured results.

Determining Dynamical Path Distributions usingMaximum Relative Entropy

DTIC Science & Technology

2015-05-31

entropy to a one-dimensional continuum labeled by a parameter η. The resulting η-entropies are equivalent to those proposed by Renyi [12] or by Tsallis [13...1995). [12] A. Renyi , “On measures of entropy and information,”Proc. 4th Berkeley Simposium on Mathematical Statistics and Probability, Vol 1, p. 547-461

Genetics Home Reference: Klinefelter syndrome

MedlinePlus

... AS, Gillam L. Thinking outside the square: considering gender in Klinefelter syndrome and 47, XXY. Int J ... Reference Celebrates Its 15th Anniversary Genetic Information Non-Discrimination Act (GINA) Turns 10 All Bulletins Features What ...

Adverse effects of homeopathy: a systematic review of published case reports and case series – response by Posadzki and Ernst

PubMed Central

Posadzki, P; Ernst, E

2013-01-01

Linked Comment: Jackson. Int J Clin Pract 2013; 67: 385. Linked Comment: Walach et al. Int J Clin Pract 2013; 67: 385–6. Linked Comment: Posadzki and Ernst. Int J Clin Pract 2013; 67: 386–7. Linked Comment: Grimes. Int J Clin Pract 2013; 67: 387. Linked Comment: Tournier et al. Int J Clin Pract 2013; 67: 388–9. PMID:23521336

Décontamination nucléaire par laser UV

NASA Astrophysics Data System (ADS)

Delaporte, Ph.; Gastaud, M.; Marine, W.; Sentis, M.; Uteza, O.; Thouvenot, P.; Alcaraz, J. L.; Le Samedy, J. M.; Blin, D.

2003-06-01

Le développement et l'utilisation de procédés propres pour le nettoyage ou la préparation de surfaces est l'une des priorités du milieu industriel. Cet intérêt est d'autant plus grand dans le domaine du nucléaire pour lequel la réduction des déchets est un axe de recherche important. Un dispositif de décontamination nucléaire par laser UV impulsionnel a été développé et testé. Il est composé. d'un laser à excimères de 1kW, d'un faisceau de fibres optiques et d'un dispositif de récupération des particules. Les essais réalisés en milieu actif ont démontré sa capacité à nettoyer des surfaces métalliques polluées par différents radioéléments avec des facteurs de décontamination généralement supérieurs à 10. Ce dispositif permet de décontaminer de grandes surfaces de géométrie simple en réduisant fortement la génération de déchets secondaires. Il est, à ce jour et dans ces conditions d'utilisations, le procédé de décontamination par voie sèche le plus efficace.

The development of spheroidal bodies theory for proto-planetary dynamics problem solving

NASA Astrophysics Data System (ADS)

Krot, A. M.

2007-08-01

There is not a full statistical equilibrium in a gas-dust proto-planetary cloud because of long relaxation time for proto-planet formation in own gravitational field. This protoplanetary system behavior can be described by Jeans equation in partial derivations relatively a distribution function. The problem for finding a general solution of Jeans equation is connected directly with an analytical expression for potential of gravitational field. Thus, the determination of gravitational potential is the main problem of statistical dynamics for proto-planetary system. The work shows this task of protoplanetary dynamics can be solved on the basis of spheroidal bodies theory [1]-[4]. Within the framework of this theory, cosmological bodies have fuzzy outlines and are represented by means of spheroidal forms. The proposed theory follows from the conception for forming a spheroidal body as a proto-planet from dust-like nebula; it permits to derive the form of distribution functions for an immovable spheroidal body [1],[2] and rotating one [3],[4] as well as their density masses (gravitational potentials and strengths) and also to find the distribution function of specific angular momentum for the rotating spheroidal body [4]. References: [1] A.M.Krot, Achievement in Modern Radioelectronics, 1996, no.8, pp.66-81 (in Russian). [2] A.M.Krot, Proc. SPIE's 13thAnnual Intern.Symp. "AeroSense", Orlando, Florida, USA, 1999, vol.3710, pp.1248-1259. [3] A.M.Krot, Proc. 35th COSPAR Scientific Assembly, Paris, France, 2004, Abstract A-00162. [4] A.Krot, Proc. EGU General Assembly, Vienna, Austria, 2006, Geophys. Res. Abstracts, vol.8, A-00216; SRef-ID: 1607-7962/gra/.

12. Historic American Buildings Survey Arthur C. Haskell, Photographer Apr. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. Historic American Buildings Survey Arthur C. Haskell, Photographer Apr. 1, 1939 (l) INT.- STAIRWAY, 4th FLOOR, LOOKING SOUTH - M.I.T., Rogers Building, 491 Boylston Street, Boston, Suffolk County, MA

Radiative lifetime and energy of the low-energy isomeric level in 229Th

NASA Astrophysics Data System (ADS)

Tkalya, E. V.; Schneider, Christian; Jeet, Justin; Hudson, Eric R.

2015-11-01

We estimate the range of the radiative lifetime and energy of the anomalous, low-energy 3 /2+(7.8 ±0.5 eV) state in the 229Th nucleus. Our phenomenological calculations are based on the available experimental data for the intensities of M 1 and E 2 transitions between excited levels of the 229Th nucleus in the Kπ[N nZΛ ] =5 /2+[633 ] and 3 /2+[631 ] rotational bands. We also discuss the influence of certain branching coefficients, which affect the currently accepted measured energy of the isomeric state. From this work, we establish a favored region, 0.66 ×106seV3/ω3≤τ ≤2.2 ×106seV3/ω3 , where the transition lifetime τ as a function of transition energy ω should lie at roughly the 95% confidence level. Together with the result of Beck et al. [LLNL-PROC-415170 (2009)], we establish a favored area where transition lifetime and energy should lie at roughly the 90% confidence level. We also suggest new nuclear physics measurements, which would significantly reduce the ambiguity in the present data.

50th Anniversary Celebration: 46th Sagamore Army Materials Research Conference on Advances and Needs in Multi-Spectral Transparent Materials Technology

DTIC Science & Technology

2008-09-01

68 (4), 883–887. Li, C-W.; Yamanishi, J. Ceram. Eng. Sci. Proc. 1989, 10, 632–645. Li, J.-G.; Ikegami , T .; Lee, J.-H.; Mori, T .; J. Am. Ceram. Soc...and Opening Remarks Dr. Allen Grum Associate Director for Science and Technology (S& T ), ARL The Impact of Research on Soldier Protection Ms. Jill...Crystal Systems, Dr. Chandra Khattak 3. MSI, Dr. Les Bowen 4. TA& T , Dr. Larry Fehrenbacher 5. CeraNova, Dr. Marina Pascucci Session IV

The Novaya Zemlya Event of 31 December 1992 and Seismic Identification Issues: Annual Seismic Research Symposium (15th) Held in Vail, Colorado on 8-10 September 1993

DTIC Science & Technology

1993-09-10

1993). A bootstrap generalizedlikelihood ratio test in discriminant analysis, Proc. 15th Annual Seismic Research Symposium, in press. I Hedlin, M., J... ratio indicate that the event does not belong to the first class. The bootstrap technique is used here as well to set the critical value of the test ...Methodist University. Baek, J., H. L. Gray, W. A. Woodward and M.D. Fisk (1993). A Bootstrap Generalized Likelihood Ratio Test in Discriminant

Protecting the Moon for research: ILEWG report

NASA Astrophysics Data System (ADS)

Foing, Bernard H.

We give a report on recommendations with emphasis on environment protection, and since last COSPAR from ILEWG International conferences Exploration and Utilisation of the Moon on held at Cape Canaveral in 2008 (ICEUM10), and in Beijing in May 2010 with IAF (GLUC -ICEUM11). We discuss the different rationale for Moon exploration, as debated at ILEWG. ILEWG Science task group has listed priorities for scientific investigations: clues on the formation and evolution of rocky planets, accretion and bombardment in the inner solar system, comparative planetology processes (tectonic, volcanic, impact cratering, volatile delivery), records astrobiology, survival of organics; past, present and future life; sciences from a biology lunar laboratory. We discuss how to preserve Moon research potential in these areas while operating with instruments, landers, rover during a cooperative robotic village, and during the transition form lunar human outpost to permanent sustainable human base. We discuss how Moon-Mars Exploration can inspire solutions to global Earth sustained development with the trade-off of In-Situ Utilisation of resources; Establishment of permanent robotic infrastructures, Environmental and planetary protection aspects and lessons for Mars; Life sciences laboratories, and support to human exploration. Co-authors: ILEWG Task Groups on Science, Technology and Human Lunar Bases ILEWG Reference documents: http://sci.esa.int/ilewg -10th ILEWG Conference on Exploration and Utilisation of the Moon, NASA Lunar Ex-ploration Analysis Group-PSace Resources Roundtable, Cape Canaveral October 2008, pro-gramme online at http://sci.esa.int/ilewg/ -9th ILEWG Conference on Exploration and Utilisation of the Moon, ICEUM9 Sorrento 2007, programme online at http://sci.esa.int/ilewg/ -8th ILEWG Conference on Exploration and Utilisation of the Moon, Beijing July 2006, programme online at http://sci.esa.int/ilewg/ -The Moon and Near Earth Objects (P. Ehrenfreund , B.H. Foing, A. Cellino Editors), Ad-vances in Space Research, Volume 37, Issue 1, pp 1-192, 2006 -7th ILEWG Conference on Exploration and Utilisation of the Moon, Toronto Sept 2005, Programme and Proceedings on line at www.ilewg.org, R. Richards et al Editors -6th ILEWG Conference on Exploration and Utilisation of the Moon, Udaipur Nov. 2004, Proceedings ( N. Bhandari Editor), Journal Earth System Science, India, 114, No6, Dec 2005, pp. 573-841 -5th ILEWG Conference on Exploration and Utilisation of the Moon, Hawaii Nov 2003, Pro-ceedings ILC2005/ICEUM5 (S.M. Durst et al Editors), Vol 108, 1-576 pp, Science and Tech-nology Series, American Astronautical Society, 2004 -'The next steps in exploring deep space -A cosmic study by the IAA', W. Huntress, D. Stetson, R. Farquhar, J. Zimmerman, B. Clark, W. O'Neil, R. Bourke and B. Foing, Acta Astronautica, Vol 58, Issues 6-7, March-April 2006, p302-377 -IAA/ESA workshop on "Next Steps in Exploring Deep Space", ESTEC 22-23 sept. 2003 (B.H. Foing W. Huntress, conveners) Lunar Exploration, Planetary and Space Science, Vol 50, issue 14-15, Dec 2002 (B.H. Foing al) -ESLAB36 symposium on "Earth-like Planets and Moons", 2002, ESA-SP514, pp. 1-356, (B.H.Foing B. Battrick, editors) -'Lunar Exploration 2000', (B.H. Foing, D. Heather, Editors), Adv. Space Research Vol 30, Nr 8, 2002 -'Earth-Moon Relationships', Proceedings of the Conference held in Padova, Italy at the Ac-cademia Galileiana di Scienze Lettere ed Arti, Nov. 2000, (C. Barbieri and F. Rampazzi, Editors), in Earth, Moon , Planets Vol. 85-86, Nos 1-3, pp 1-575, 2001 -4th International Conference on Exploration and Utilisation of the Moon, ESTEC, 2000, ESA SP-462 (B.H. Foing M. Perry, editors) -Investing in Space: The Challenge for Europe. Long-Term Space Policy Committee, Second Report, May 1999. ESA-SP-2000 -2nd International Lunar Workshop, held at Kyoto in October 1996, Proceedings, H. Mizutani, editor, Japan Space Forum Publisher, 1997 International Lunar Workshop, 1994 May 31-June 3, Beatenberg, Switzerland. Proceedings. Ed. Balsiger, H. et al. European Space Agency, 1994. ESA-SP-1170 -Astronomy and Space Science from the Moon', Proceedings of COSPAR/IAF session at World Congress, Washington, (B.H. Foing et al editors), Advances in Space Research, Volume 14, Issue 6, 1994 -Mission to the Moon, Europe's Priorities for Scientific Exploration and Utilisation of the Moon', R.M. Bonnet et al, European Space Agency, ESA SP-1150, June 1992

Changes in growth and survival of Bifidobacterium by coculture with Propionibacterium in soy milk, cow's milk, and modified MRS medium.

PubMed

Wu, Qian Qian; You, Hyun Ju; Ahn, Hyung Jin; Kwon, Bin; Ji, Geun Eog

2012-06-15

Bifidobacterium adolescentis Int57 (Int57) and Propionibacterium freudenreichii subsp. shermanii ATCC 13673 (ATCC 13673) were grown either in coculture or as pure cultures in different media, such as cow's milk, soybean milk, and modified MRS medium. The viable cell counts of bacteria, changes in pH, concentrations of organic acids, and contents of various sugars were analyzed during incubation up to 7days. In soy milk, the survival of cocultured Int57 was six times higher than the monocultured cells, and ATCC 13673 cocultured with Int57 consumed 69.4% of lactic acid produced by Int57 at the end of fermentation. In cow's milk, coculture with ATCC 13673 increased the growth of Int57 from 24h until 120h by approximately tenfold and did not affect the survival of Int57 cells. After 96h of fermentation of modified MRS, the survival of ATCC 13673 cells cocultured with Int57 increased by 3.2- to 7.4-folds as compared with ATCC 13673 monoculture, whereas the growth of Int57 cells was unaffected. The growth and metabolic patterns of two strains during coculture showed noticeable differences between food grade media and laboratory media. The consumption of stachyose in soy milk during coculture of Int57 with ATCC 13673 was increased by more than twice compared with Int57 monoculture, and completed within 24h. The combinational use of Bifidobacterium and Propionibacterium could be applied to the development of fermented milk or soy milk products. Copyright © 2012 Elsevier B.V. All rights reserved.

Cylindrical Explosive Dispersal of Metal Particles: Predictive Calculations in SUpport of Experimental Trials

DTIC Science & Technology

2007-12-11

motivated by an experimental effort at the High Explosives R&D facility at Eglin AFB that aims to simulate dispersal and afterburning effects using dense...3] Ripley, R.C., Donahue, L., Dunbar, T.E., and Zhang, F., Explosion performance of aluminized TNT in a chamber, Proc. 19th Military Aspects of

An XCP User’s Guide and Reference Manual

DTIC Science & Technology

1993-08-01

Sanford, and J. R. Haustein , 1985: Observing hurricane-driven waves and currents, Proc. 17th Annual Offshore Technology Conference, OTC 4934, 331-339...of Washington, Seattle, IWA, 164 pp. I 3 TR 9309 A3 I I Sanford, T. B., P. G. Black, J. R. Haustein , J. W. Feeney, G. Z. Forristall, and J. F. Price

3 CFR 9055 - Proclamation 9055 of November 5, 2013. Veterans Day, 2013

Code of Federal Regulations, 2014 CFR

2014-01-01

... marking the 60th anniversary of the Korean War Armistice, we resolved that in the United States of America... 3 The President 1 2014-01-01 2014-01-01 false Proclamation 9055 of November 5, 2013. Veterans Day... Proc. 9055 Veterans Day, 2013By the President of the United States of America A Proclamation On...

Clinical features and outcome of typhoid fever and invasive non-typhoidal salmonellosis in a tertiary hospital in Belgium: analysis and review of the literature.

PubMed

Yombi, J C; Martins, L; Vandercam, B; Rodriguez-Villalobos, H; Robert, A

2015-08-01

Typhoid fever (TF) occurs rarely in industrialized countries because of advances in health care and improvement of drinking water. Conversely, non-typhoid salmonellosis (NTS) remains widespread, because of food contamination or asymptomatic carriage. Non-typhoid salmonellosis can be severe when becoming invasive non-typhoid salmonellosis (iNTS). Although established prognostic indicators of the two pathologies are different, direct comparisons between iNTS and TF in the literature remain scarce. The purpose of this study was to analyse and compare demographic, clinical features and outcome of hospitalized patients with TF and iNTS. Demographic, clinical features and outcome were retrospectively analysed in a series of patients hospitalized between 2007 and 2012. A total of 33 patients were enrolled, including 13 with established TF and 20 with iNTS. No differences between TF and iNTS patients were observed in incidence of fever, abdominal cramps, diarrhoea, headache, nausea and vomiting and duration of antibiotic therapy (≤ 7 days in both groups). Although the clinical outcome of TF patients was identical to that of iNTS patients, including incidence of complications, length of hospitalization and mortality (1/13 (7.7%) vs 2/20 (10%), P = 0.43), comorbidities were less frequent in the TF group than in the iNTS group (2/13 vs 15/20, P = 0.003). The clinical profile and outcome of TF patients are similar to those with iNTS. Although comorbidities are more often associated with iNTS, the results of our study suggest that clinical management of these two diseases should remain similar.

Application of various FLD modelling approaches

NASA Astrophysics Data System (ADS)

Banabic, D.; Aretz, H.; Paraianu, L.; Jurco, P.

2005-07-01

This paper focuses on a comparison between different modelling approaches to predict the forming limit diagram (FLD) for sheet metal forming under a linear strain path using the recently introduced orthotropic yield criterion BBC2003 (Banabic D et al 2005 Int. J. Plasticity 21 493-512). The FLD models considered here are a finite element based approach, the well known Marciniak-Kuczynski model, the modified maximum force criterion according to Hora et al (1996 Proc. Numisheet'96 Conf. (Dearborn/Michigan) pp 252-6), Swift's diffuse (Swift H W 1952 J. Mech. Phys. Solids 1 1-18) and Hill's classical localized necking approach (Hill R 1952 J. Mech. Phys. Solids 1 19-30). The FLD of an AA5182-O aluminium sheet alloy has been determined experimentally in order to quantify the predictive capabilities of the models mentioned above.

The Fractionation of Highly Siderophile Elements (HSE) in Impact Melts and the Determination of the Meteoritic Components

NASA Astrophysics Data System (ADS)

Schmidt, G.; Palme, H.; Kratz, K. L.

1995-09-01

Lunar highland rocks contain an excess of siderophile elements, which has been attributed to meteoritic influx after the formation of the lunar crust [1-4]. Siderophile element enrichment has subsequently become a standard method for the identification of terrestrial impact craters. Janssens et al. [5], Grieve [6] and Palme et al. [7] have shown the dominant role of impact melt as the main carrier of meteoritic material at large terrestrial impact craters. This has been demonstrated at Clearwater East [8], Lappajarvi [9-11], Saaksjarvi [12], Brent [6] and Rochechouart [5]. The amount of projectile material incorporated in impact melt sheets is generally low (<1%). The highest recorded is 8% at East Clearwater, where the siderophiles are carried in a sulphide phase. In other cases, searches for siderophile anomalies at some impact structure have been largely unsuccessful. Melt bearing mixed breccias (suevitic melt) and fall-back sediments have been found to be free of meteoritic components in Brent, Lappajarvi and Ries samples [6,9,12-14]. However, from approximately 130 craters which are currently known on Earth only four clearly identified chondrites have been found as projectiles of large craters [15,16]. In this study we analyzed twenty-two impact melt samples (10 g) from Saaksjarvi (Finland), Mien and Dellen (Sweden) impact craters for Os, Re, Ir, Ru, Rh, Pd and Au by a slightly modified version of the fire assay neutron activation method using nickel sulphide as the collector [13,14]. All samples were obtained from the collection of the University of Munster. Only fresh, nearly fragment-free, fine grained samples without any sign of alteration were selected for chemical studies. All samples have been described previously [17]. The INAA procedure involved two irradiations: a short irradiation for Rh and a long irradiation for the other elements. Impact melts from Saaksjarvi are highly enriched in PGEs. The flat siderophile pattern suggests that the meteoritic component (PGE/CI = 3x10^-3 to 9x10^-3 relative to CI) in the Saaksjarvi impact melt is relatively unfractionated. Stony-iron meteorites (pallasites) as proposed earlier [7] can therefore be excluded as possible contaminants because Pd and Ir are highly fractionated in pallasites [18]. Impact melts from Mien and Dellen are moderately enriched in PGE. The concentrations are similar (PGE/CI = 3x10^-4 to 1x10^-3 relative to CI). The flat siderophile pattern of the Mien and Dellen impact samples are compatible with carbonaceous chondrite type of material, but a clear geochemical association of any of the known meteorite types is not possible because of the low signal-to-background ratio for Rh, Ru, Pd, and Au. Samples from all impact craters have low Os/PGE ratios (Os/Ir(sub)melt =0.24) compared to chondritic ratios (Os/Ir(sub)CI=1.06). It seems that the oxygen fugacity at the time of impact melting, vaporization and crystallization of the melt body may play the dominant role in the fractionation of Os and PGEs. If Os have been partially lost by volatilization of OsO4 under oxidizing conditions, then Ir is the only element to confirm meteoritic enrichments down to a level of 2x10^-4 CI chondrite. None of the other elements determined are sufficiently sensitive indicators to confirm small meteoritic enrichments, equivalent to <10^-3 CI chondrite, because of low CI/Earth crust-ratios. Acknowledgements. This work was supported by DFG. References: [1] Wasson J. T. et al. (1975) Moon, 13, 121-141. [2] Gros J. et al. (1976) Proc. LSC 7th, 2403-2425. [3] Hertogen J. et al. (1977) Proc. LSC 8th, 17-45. [4] Palme H. (1980) Proc. LPSC 11th, 481-506. [5] Janssens M.-J. et al. (1977) JGR, 82, 750-758. [6] Grieve R. A. F. (1978) Proc. LPSC 9th, 2579-2608. [7] Palme H. et al. (1980) LPSC XI, 848-850. [8] Palme H. et al. (1978) GCA, 42, 313-323. [9] Reimold W. U. and Stoffler D. (1980) Meteoritics, 14, 526-528. [10] Reimold W. U. (1980) Ph. D. thesis, Univ. of Munster, 172 pp. [11] Gobel E. et al. (1980) Z. Naturforsch., 35a, 197-203. [12] Morgan J. W. et al. (1979) GCA, 43, 803-815. [13] Schmidt G. and Pernicka E. (1991) Meteoritics, 26, 392. [14] Schmidt G. and Pernicka E. (1994) GCA, 58, 5083-5090. [15] Palme H. et al. (1981) GCA, 45, 2417-2424. [16] Grieve R. A. F. (1991) Meteoritics, 26, 174-194. [17] Maerz U. (1979) Diploma thesis, Univ. of Munster, 115 pp. [18] Davis A. M. (1977) Ph. D. thesis, Yale University, 285 pp.

77 FR 68149 - Karen Paul Holley, M.D.; Decision and Order

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-15

... meaningless tasks. See Philip E. Kirk, M.D., 48 FR 32887 (1983), aff'd sub nom. Kirk v. Mullen, 749 F.2d 297...); NLRB v. Int'l Assoc. of Bridge, Structural & Ornamental Ironworkers, AFL-CIO, 549 F.2d 634 (9th Cir. 1977); United States v. Consol. Mines & Smelting Co., 455 F.2d 432, 453 (9th Cir. 1971). Thus, it is...

Nuclear planetology: understanding planetary mantle and crust formation in the light of nuclear and particle physics

NASA Astrophysics Data System (ADS)

Roller, Goetz

2017-04-01

The Hertzsprung-Russell (HR) diagram is one of the most important diagrams in astronomy. In a HR diagram, the luminosity of stars and/or stellar remnants (white dwarf stars, WD's), relative to the luminosity of the sun, is plotted versus their surface temperatures (Teff). The Earth shows a striking similarity in size (radius ≈ 6.371 km) and Teff of its outer core surface (Teff ≈ 3800 K at the core-mantle-boundary) with old WD's (radius ≈ 6.300 km) like WD0346+246 (Teff ≈ 3820 K after ≈ 12.7 Ga [1]), which plot in the HR diagram close to the low-mass extension of the stellar population or main sequence. In the light of nuclear planetology [2], Earth-like planets are regarded as old, down-cooled and differentiated black dwarfs (Fe-C BLD's) after massive decompression, the most important nuclear reactions involved being 56Fe(γ,α)52Cr (etc.), possibly responsible for extreme terrestrial glaciations events ("snowball" Earth), together with (γ,n), (γ,p) and fusion reactions like 12C(α,γ)16O. The latter reaction might have caused oxidation of the planet from inside out. Nuclear planetology is a new research field, tightly constrained by a coupled 187Re-232Th-238U systematics [3-5]. By means of nuclear/quantum physics and taking the theory of relativity into account, it aims at understanding the thermal and chemical evolution of Fe-C BLD's after gravitational contraction (e.g. Mercury) or Fermi-pressure controlled collapse (e.g. Earth) events after massive decompression, leading possibly to an r-process event, towards the end of their cooling period [2]. So far and based upon 187Re-232Th-238U nuclear geochronometry, the Fe-C BLD hypothesis can successfully explain the global terrestrial MORB 232Th/238U signature [5]. Thus, it may help to elucidate the DM (depleted mantle), EMI (enriched mantle 1), EMII (enriched mantle 2) or HIMU (high U/Pb) reservoirs [6], and the 187Os/188Os isotopic dichotomy in Archean magmatic rocks and sediments [7]. Here I present a conceptual model constraining the evolution of a rocky planet like Earth or Mercury from a stellar precursor of the oldest population to a Fe-C BLD, shifting through different spectral classes in a HR diagram after massive decompression and tremendous energy losses. In the light of WD/BLD cosmochronology [1], solar system bodies like Earth, Mercury and Moon are regarded as captured interlopers from the Galactic bulge, Earth and Moon possibly representing remnants of an old binary system. Such a preliminary scenario is supported by similar ages obtained from WD's for the Galactic halo [1] and, independently, by means of 187Re-232Th-238U nuclear geochronometry [3, 4], together with recent observations extremely metal-poor stars from the cosmic dawn in the bulge of the Milky Way [8]. This might be further elucidated in the near future by Th/U cosmochronometry based upon a nuclear production ratio Th/U = 0.96 [9] and additionally by means of a newly developed nucleogeochronometric age dating method for stellar spectroscopy [9-11]. The model shall stimulate geochemical data interpretation from a different perspective, to constrain the evolution and differentiation of planetary or lunar crusts and mantles in general. [1] Fontaine et al. (2001), Public. Astron. Soc. of the Pacific 113, 409-435. [2] Roller (2015), Abstract T34B-0407, AGU Spring Meeting 2015. [3] Roller (2016), Goldschmidt Conf. Abstr. 26, 2642. [4] Roller (2015), Goldschmidt Conf. Abstr. 25, 2672. [5] Roller (2015), Geophys. Res. Abstr. 18, EGU2016-33. [6] Arevalo et al. (2010), Chem. Geol. 271, 70-85. [7] Roller (2015), Geophys. Res. Abstr. 17, EGU2015-2399. [8] Howes et al. (2015), Nature 527, 484-487. [9] Roller (2016), JPS Conf. Proc., Nuclei in the Cosmos (NIC XIV), Niigata, Japan, subm. (NICXIV-001); NICXIV Abstr. #1570244284. [10] Roller (2016), JPS Conf. Proc., Nuclei in the Cosmos (NIC XIV), Niigata, Japan, subm. (NICXIV-002); NICXIV Abstr. #1570244285. [11] Roller (2016), JPS Conf. Proc., Nuclei in the Cosmos (NIC XIV), Niigata, Japan, subm. (NICXIV-003); NICXIV Abstr. #1570244281.

3 CFR 8848 - Proclamation 8848 of August 24, 2012. Women's Equality Day, 2012

Code of Federal Regulations, 2013 CFR

2013-01-01

... 24, 2012 Proc. 8848 Women's Equality Day, 2012By the President of the United States of America A... secured the right to vote for America's women. The product of profound struggle and fierce hope, the 19th... 3 The President 1 2013-01-01 2013-01-01 false Proclamation 8848 of August 24, 2012. Women's...

Impact of clinical follow-up and diagnostic testing on intervention for tetralogy of Fallot

PubMed Central

House, Aswathy Vaikom; Danford, David A; Spicer, Robert L; Kutty, Shelby

2015-01-01

Objective Our purpose was to evaluate yield of tools commonly advocated for surveillance of tetralogy of Fallot (TOF). Methods All patients (pts) with TOF, seen at any time from 1/2008 to 9/2013 in an academic cardiology practice were studied. At the first and each subsequent outpatient visit, the use of tools including history and physical (H&P), ECG, Holter (HOL), echocardiogram (Echo), MR or CT (MR-CT) and stress testing (STR) were noted. Recommendations for intervention (INT) and for time to next follow-up were recorded; rationale for each INT with attribution to one or more tools was identified. Results There were 213 pts (mean 11.5 years, 130 male) who had 916 visits, 123 of which (13.4%) were associated with 138 INTs (47 surgical, 54 catheter-mediated, 37 other medical). Recommended follow-up interval was 9.44±6.5 months, actual mean follow-up interval was 11.7 months. All 916 (100%) patient visits had a H&P which contributed to 47.2% of INT decisions. Echo was performed in 652 (71.2%) of visits, and contributed to 53.7% of INTs. MR-CT was obtained in 129 (14.1%) of visits, and contributed to 30.1% of INTs. ECG was applied in 137 (15%) visits, and contributed to 1.6% of INTs. HOL was obtained in 188 (20.5%) visits, and contributed to 11.3% of INTs. STR was performed at 101 (11%) of visits, and contributed to 8.9% of INTs. Conclusions INTs are common in repaired TOF, but when visits average every 11–12 months, most visits do not result in INT. H&P, Echo and HOL were the most frequently applied screens, and all frequently yielded relevant information to guide INT decisions. STR and MR/CT were applied as targeted testing and in this limited, non-screening role had high relevance for INT. There was low utilisation of ECG and major impact on INT was not demonstrated. Risk stratification in TOF may be possible, and could result in more efficient surveillance and targeted testing. PMID:25973212

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johar, Saffuwan Mohamed, E-mail: saffuwan@uthm.edu.my; Embong, Zaidi; Research Center for Soft Soil

An assessment of absorbed dose and radiation hazard index as well as its relationship with soil pH was performed in this study. The area was chosen due to its variety of soil types from the Alluvial and the Sedentary group. The radioactivity concentration levels and the soil acidity were measured using the Canberra GC3518 high pure germanium with a relative efficiency of 35% at 1.3 MeV and the Takemura Soil pH and Moisture Tester (DM15), respectively. Overall results show the Holyrood-Lunas soil of Alluvial group recorded the highest external terrestrial gamma radiation dose rate (TGRD) of 286.4±37.9 nGy h{sup −1} andmore » radioactivity concentrations of 78.1±8.9 Bq kg{sup −1} ({sup 226}Ra), 410.5±55.4 Bq kg{sup −1} ({sup 232}Th) and 56.4±8.8 Bq kg{sup −1} ({sup 40}K), respectively, while the Peat soil of Alluvial group recorded the lowest TGRD of 4.4±2.7 nGy h{sup −1} and radioactivity concentrations of 4.8±1.7 Bq kg{sup −1} ({sup 226}Ra), 3.1±1.1 Bq kg{sup −1} ({sup 232}Th) and 6.1±2.0 Bq kg{sup −1} ({sup 40}K), respectively. The estimated mean outdoor annual effective dose, the mean radium equivalent activity (R{sub eq}) and the mean external (H{sub ext}) and internal hazard index (H{sub int}) associated with the alluvial and sedentary soil group were evaluated at 0.15 and 0.20 mSv, 280 and 364 Bq kg{sup −1}, H{sub ext} = 0.78 and 1.01, and H{sub int} = 0.93 and 1.26, respectively. Correlation analysis between 238U, {sup 232}Th and {sup 40}K with soil pH level for alluvial group was r = +0.68, +0.48 and 0, respectively, while for sedentary soil, the Pearson’s, r = −0.30, −0.90 and +0.14, respectively.« less

Les enjuex éthiques entourant la recherche en santé sur les enfants

PubMed Central

2008-01-01

RÉSUMÉ La recherche en santé est un devoir moral parce qu’elle est la base des soins probants prodigués par tous les dispensateurs de soins. Des politiques et des règlements précis régissent la tenue des recherches sur des humains. Il faut procéder à une évaluation éthique d’un projet de recherche donné avant de pouvoir l’entreprendre. La recherche sur les enfants pose d’énormes défis en matière de consentement éclairé et d’assentiment, de vulnérabilité et de potentiel de conflit d’intérêts (CDI). Les chercheurs en santé pédiatrique devraient prôner la participation des enfants à la recherche, tout en se montrant attentifs à en limiter les risques.

Misbalance in type III collagen formation/degradation as a novel serological biomarker for penetrating (Montreal B3) Crohn's disease.

PubMed

van Haaften, W T; Mortensen, J H; Karsdal, M A; Bay-Jensen, A C; Dijkstra, G; Olinga, P

2017-07-01

Misbalances in extracellular matrix turnover are key factors in the development of stricturing (Montreal B2) and penetrating (Montreal B3) Crohn's disease. To determine whether serological markers for collagen formation and degradation could serve as biomarkers for complications of Crohn's disease. Serum biomarkers for type I, III, V and VI collagen formation (P1NP, Pro-C3, Pro-C5, Pro-C6) and matrix metalloproteinase mediated degradation (C1M, C3M, C5M and C6M) were measured in a retrospective, single centre cohort of 112 patients with Crohn's disease in the terminal ileum (nonstricturing/nonpenetrating: n=40, stricturing: n=55, penetrating: n=17) and 24 healthy controls. Active inflammation was defined as CRP >5 mg/L. C3M and Pro-C5 levels were higher in penetrating vs nonpenetrating/nonstricturing and stricturing disease (33.6±5 vs 25.8±2.2 [P=.004] and 27.2±2.3 [P=.018] nmol/L C3M, 1262.7±259.4 vs 902.9±109.9 [P=.005] and 953.0±106.4 [P=.015] nmol/L Pro-C5). C1M (71.2±26.1 vs 46.2±6.2 nmol/L [P<.001]), C3M (31.6±3.9 vs 26.1±1.6 nmol/L [P=.002] and Pro-C5 levels (1171.7±171.5 vs 909.6±80.4 nmol/L [P=.002]) were higher in patients with active inflammation vs without active inflammation. Pro-C3/C3M-ratios were best to differentiate between penetrating vs nonstricturing/nonpenetrating and stricturing disease with area under the curves of 0.815±0.109 (P<.001) and 0.746±0.114 (P=.002) respectively. Serological biomarkers show that penetrating Crohn's disease is characterised by increased matrix metalloproteinase-9 degraded type III collagen and formation of type V collagen. Active inflammation in Crohn's disease is characterised by increased formation of type V collagen and increased matrix metalloproteinase mediated breakdown of type I, III collagen. Pro-C3/C3M ratios are superior in differentiating between penetrating Crohn's disease vs inflammatory and stricturing Crohn's disease. © 2017 The Authors. Alimentary Pharmacology and Therapeutics published by John Wiley & Sons Ltd.

Wound Healing Studies.

DTIC Science & Technology

1986-11-15

Conference on Medical Research, SantaFe, New Mexico , September 24-27, 1979. Columbus, Ohio: Ross Laboratories, 1981, pp. 1-141 (Nov.). 63. Barbul, A...Levenson, S.M., Rettura, G.: Action of vitamin A in pox -vaccinated mice. 170th National Meeting, American Chemical Society, Chicago, Illinois...Vitamin A in Cultures of Embryonic Chicken Skin Explanted at Different Stages of Differentiation, Proc. R. Soc. London 146: 242-245, 1957. 4. Manville A

Fire Suppression Properties of Very Fine Water Mist

DTIC Science & Technology

2005-01-01

with the University of Heidelberg, developed an in situ oxygen sensor based on tunable diode laser absorption spectroscopy ( TDLAS ) to provide absolute... oxygen number densities in the presence of mist.3 Th e TDLAS oxygen sensor provides real-time, calibra- tion-free, quantitative oxygen ...Determination of Molecular Oxygen Concentrations in Full-Scale Fire Suppression Tests Using TDLAS ,” Proc. Combust. Inst. 29, 353-360 (2002).

Semiconductor Diamond Technology

DTIC Science & Technology

1991-12-31

temperature technologically permits diamond applica- tion to materials which heretofore could not survive the temperature extremes. Scien- tifically, tle...Institute, Research Triangle Park. NC 27709 [3D. Huang, and KM.ekl I Department of Materials Science and Engineering, Pennsylvania State University...34, edited by g. Messier, J.T. Glass, J.E. Butler, and R. Roy ( Materials Research Society, Pittsburgh, PA, 1991). and Conf. Proc. 179th meeting of’ The

Rock Quality Designation (RQD) after Twenty Years.

DTIC Science & Technology

1989-02-01

strength, and seismic refraction velocity for prediction of single-tooth rippability with a D-8 dozer, all correlated by field rippability tests...Smith (1986) utilizes the RMR System to estimate rippability . Kirsten (1988) characterizes excavatability for trenching, digging, dozing, and...Lisbon, Portugal, Vol. 1, pp. II. 33 - II. 42. Smith, H.J., (1986), "Estimating Rippability by Rock Mass Classification," Proc. 27th U.S. Symposium on

High-Level Vision and Planning Workshop Proceedings

DTIC Science & Technology

1989-08-01

Correspondence in Line Drawings of Multiple View-. In Proc. of 8th Intern. Joint Conf. on Artificial intellignece . 1983. [63] Tomiyasu, K. Tutorial...joint U.S.-Israeli workshop on artificial intelligence are provided in this Institute for Defense Analyses document. This document is based on a broad...participants is provided along with applicable references for individual papers. 14. SUBJECT TERMS 15. NUMBER OF PAGES Artificial Intelligence; Machine Vision

Developing Decision-Making Skills Using Immersive VR

DTIC Science & Technology

2013-06-14

Institution: Department of Otolaryngology Mailing Address: Level 2, Royal Victorian Eye and Ear Hospital, 32, Gisborne St, East Melbourne...reliability of this measure. We will also intend to integrate other data models into to the feedback system such as Pattern based models [8], and... Pattern -Based Real-Time Feedback for a Temporal Bone Simulator’, Proc. of the 19th ACM Symposium on Virtual Reality Software and Technology, 2013

Clinical study to know the efficacy of Amlexanox 5% with other topical Antiseptic, Analgesic and Anesthetic agents in treating minor RAS.

PubMed

Darshan, D D; Kumar, C N Vijay; Kumar, A D Manoj; Manikantan, N S; Balakrishnan, Dhanya; Uthkal, M P

2014-02-01

To evaluate the efficacy of topical antiinflammatory agent (amlexanox 5%), along with topical antiseptic, analgesic, and anesthetic agent (benzalkonium chloride 0.01%, choline salicylate 8.7% and lidocaine hydrochloride 2%), in promoting ulcer healing, decreasing ulcer size, erythema, pain and recurrence in minor RAS. A randomized control trial was conducted on 100 patients of RAS who fulfilled the inclusion criteria. The number, size, erythema and pain with the ulcer were recorded. Visual analogue scale (VAS) and erythema scale were used to record pain and erythema. 50 patients comprising the study group received anti inflammatory paste (amlexanox 5%) applied four times daily and the control group of 50 patients received topical antiseptic, analgesic, and anesthetic agent (benzalkonium chloride 0.01%, choline salicylate 8.7% and lidocaine hydrochloride 2%) paste, patients were evaluated after 3rd, 6th, 9th and on 30th, 60th day for recurrence. The study group had reduction in ulcer number, size; erythema, pain and frequency of ulcers during follow up. The healing period and recurrence of ulceration reduced in both the groups but the study group had significant reduction in 30th and 60th day follow up for recurrence of ulcers. Amlexanox 5% can reduce the frequency, duration and symptoms associated with the aphthous ulcers with no sideeffects attributed to the drug. How to cite the article: Darshan DD, Kumar CN, Kumar AD, Manikantan NS, Balakrishnan D, Uthkal MP. Clinical study to know the efficacy of Amlexanox 5% with other topical Antiseptic, Analgesic and Anesthetic agents in treating minor RAS. J Int Oral Health 2014;6(1);5-11.

Clinical study to know the efficacy of Amlexanox 5% with other topical Antiseptic, Analgesic and Anesthetic agents in treating minor RAS

PubMed Central

Darshan, D D; Kumar, C N Vijay; Kumar, A D Manoj; Manikantan, N S; Balakrishnan, Dhanya; Uthkal, M P

2014-01-01

Background: To evaluate the efficacy of topical antiinflammatory agent (amlexanox 5%), along with topical antiseptic, analgesic, and anesthetic agent (benzalkonium chloride 0.01%, choline salicylate 8.7% and lidocaine hydrochloride 2%), in promoting ulcer healing, decreasing ulcer size, erythema, pain and recurrence in minor RAS. Materials & Methods: A randomized control trial was conducted on 100 patients of RAS who fulfilled the inclusion criteria. The number, size, erythema and pain with the ulcer were recorded. Visual analogue scale (VAS) and erythema scale were used to record pain and erythema. 50 patients comprising the study group received anti inflammatory paste (amlexanox 5%) applied four times daily and the control group of 50 patients received topical antiseptic, analgesic, and anesthetic agent (benzalkonium chloride 0.01%, choline salicylate 8.7% and lidocaine hydrochloride 2%) paste, patients were evaluated after 3rd, 6th, 9th and on 30th, 60th day for recurrence. Results: The study group had reduction in ulcer number, size; erythema, pain and frequency of ulcers during follow up. The healing period and recurrence of ulceration reduced in both the groups but the study group had significant reduction in 30th and 60th day follow up for recurrence of ulcers. Conclusion: Amlexanox 5% can reduce the frequency, duration and symptoms associated with the aphthous ulcers with no sideeffects attributed to the drug. How to cite the article: Darshan DD, Kumar CN, Kumar AD, Manikantan NS, Balakrishnan D, Uthkal MP. Clinical study to know the efficacy of Amlexanox 5% with other topical Antiseptic, Analgesic and Anesthetic agents in treating minor RAS. J Int Oral Health 2014;6(1);5-11. PMID:24653596

CORSICA modelling of ITER hybrid operation scenarios

NASA Astrophysics Data System (ADS)

Kim, S. H.; Bulmer, R. H.; Campbell, D. J.; Casper, T. A.; LoDestro, L. L.; Meyer, W. H.; Pearlstein, L. D.; Snipes, J. A.

2016-12-01

The hybrid operating mode observed in several tokamaks is characterized by further enhancement over the high plasma confinement (H-mode) associated with reduced magneto-hydro-dynamic (MHD) instabilities linked to a stationary flat safety factor (q ) profile in the core region. The proposed ITER hybrid operation is currently aiming at operating for a long burn duration (>1000 s) with a moderate fusion power multiplication factor, Q , of at least 5. This paper presents candidate ITER hybrid operation scenarios developed using a free-boundary transport modelling code, CORSICA, taking all relevant physics and engineering constraints into account. The ITER hybrid operation scenarios have been developed by tailoring the 15 MA baseline ITER inductive H-mode scenario. Accessible operation conditions for ITER hybrid operation and achievable range of plasma parameters have been investigated considering uncertainties on the plasma confinement and transport. ITER operation capability for avoiding the poloidal field coil current, field and force limits has been examined by applying different current ramp rates, flat-top plasma currents and densities, and pre-magnetization of the poloidal field coils. Various combinations of heating and current drive (H&CD) schemes have been applied to study several physics issues, such as the plasma current density profile tailoring, enhancement of the plasma energy confinement and fusion power generation. A parameterized edge pedestal model based on EPED1 added to the CORSICA code has been applied to hybrid operation scenarios. Finally, fully self-consistent free-boundary transport simulations have been performed to provide information on the poloidal field coil voltage demands and to study the controllability with the ITER controllers. Extended from Proc. 24th Int. Conf. on Fusion Energy (San Diego, 2012) IT/P1-13.

Different loading schemes in power training during the preseason promote similar performance improvements in Brazilian elite soccer players.

PubMed

Loturco, Irineu; Ugrinowitsch, Carlos; Tricoli, Valmor; Pivetti, Bruno; Roschel, Hamilton

2013-07-01

The present study investigated the effects of 2 different power training loading schemes in Brazilian elite soccer players. Thirty-two players participated in the study. Maximum dynamic strength (1RM) was evaluated before (B), at midpoint (i.e., after 3 weeks; T1), and after 6 weeks (T2) of a preseason strength/power training. Muscle power, jumping, and sprinting performance were evaluated at B and T2. Players were randomly allocated to 1 of 2 training groups: velocity-based (VEL: n = 16; age, 19.18 ± 0.72 years; height, 173 ± 6 cm; body mass, 72.7 ± 5.8 kg) or intensity-based (INT: n = 16; age, 19.11 ± 0.7 years; height, 172 ± 4.5 cm; body mass, 71.8 ± 4.6 kg). After the individual determination of the optimal power load, both groups completed a 3-week traditional strength training period. Afterward, the VEL group performed 3 weeks of power-oriented training with increasing velocity and decreasing intensity (from 60 to 30% 1RM) throughout the training period, whereas the INT group increased the training intensity (from 30 to 60% 1RM) and thus decreased movement velocity throughout the power-oriented training period. Both groups used loads within ±15% (ranging from 30 to 60% 1RM) of the measured optimal power load (i.e., 45.2 ± 3.0% 1RM). Similar 1RM gains were observed in both groups at T1 (VEL: 9.2%; INT: 11.0%) and T2 (VEL: 19.8%; INT: 22.1%). The 2 groups also presented significant improvements (within-group comparisons) in all of the variables. However, no between-group differences were detected. Mean power in the back squat (VEL: 18.5%; INT: 20.4%) and mean propulsive power in the jump squat (VEL: 29.1%; INT: 31.0%) were similarly improved at T2. The 10-m sprint (VEL: -4.3%; INT: -1.6%), jump squat (VEL: 7.1%; INT: 4.5%), and countermovement jump (VEL: 6.7%; INT: 6.9%) were also improved in both groups at T2. Curiously, the 30-m sprint time (VEL: -0.8%; INT: -0.1%) did not significantly improve for both groups. In summary, our data suggest that male professional soccer players can achieve improvements in strength- and power-related abilities as a result of 6 weeks of power-oriented training during the preseason. Furthermore, similar performance improvements are observed when training intensity manipulation occurs around only a small range within the optimal power training load.

Integrative Neuromuscular Training and Sex-Specific Fitness Performance in 7-Year-Old Children: An Exploratory Investigation

PubMed Central

Faigenbaum, Avery D.; Myer, Gregory D.; Farrell, Anne; Radler, Tracy; Fabiano, Marc; Kang, Jie; Ratamess, Nicholas; Khoury, Jane; Hewett, Timothy E

2014-01-01

Context: Integrative neuromuscular training (INT) has successfully enhanced physical fitness and reduced abnormal biomechanics, which appear to decrease injury rates in adolescent female athletes. If not addressed at the proper time, low levels of physical fitness and abnormal mechanics may predispose female athletes to an increased risk of musculoskeletal injuries. Objectives To evaluate sex-specific effects of INT on selected measures of health- and skill-related fitness in children during physical education (PE). Design: Cohort study. Setting: Public primary school. Patients or Other Participants: Forty children (16 boys, 24 girls; age = 7.6 ± 0.3 years, height = 124.5 ± 6.4 cm, mass = 29.5 ± 7.6 kg) from 2 second-grade PE classes. Intervention(s): The classes were randomized into the PE-plus-INT group (10 boys, 11 girls) or the control group (6 boys, 13 girls) that participated in traditional PE. The INT was performed 2 times per week during the first approximately 15 minutes of each PE class and consisted of body weight exercises. Main Outcome Measure(s): Push-up, curl-up, standing long jump, single-legged hop, single-legged balance, sit-and-reach flexibility test, shuttle run, and 0.8-km run. Results: At baseline, the boys demonstrated higher levels of performance in most of the fitness measurements as evidenced by greater performance on the push-up, standing long jump, single-legged hop, shuttle run, and 0.8-km run (P < .05). In the evaluation of the training effects, we found intervention effects in the girls for enhanced INT-induced gains in performance relative to the control group on the curl-up, long jump, single-legged hop, and 0.8-km run (P < .05) after controlling for baseline. Boys did not demonstrate similar adaptations from the INT program (P ≥ .05). Conclusions: These data indicate that INT is an effective and time-efficient addition to PE for enhancing motor skills and promoting physical activity in children. Seven-year-old girls appeared to be more sensitive to the effects of INT than 7-year-old boys. Future research is warranted to confirm these effects in larger cohorts of children. PMID:24490841

Integrative neuromuscular training and sex-specific fitness performance in 7-year-old children: an exploratory investigation.

PubMed

Faigenbaum, Avery D; Myer, Gregory D; Farrell, Anne; Radler, Tracy; Fabiano, Marc; Kang, Jie; Ratamess, Nicholas; Khoury, Jane; Hewett, Timothy E

2014-01-01

Integrative neuromuscular training (INT) has successfully enhanced physical fitness and reduced abnormal biomechanics, which appear to decrease injury rates in adolescent female athletes. If not addressed at the proper time, low levels of physical fitness and abnormal mechanics may predispose female athletes to an increased risk of musculoskeletal injuries. To evaluate sex-specific effects of INT on selected measures of health- and skill-related fitness in children during physical education (PE). Cohort study. Public primary school. Forty children (16 boys, 24 girls; age = 7.6 ± 0.3 years, height = 124.5 ± 6.4 cm, mass = 29.5 ± 7.6 kg) from 2 second-grade PE classes. The classes were randomized into the PE-plus-INT group (10 boys, 11 girls) or the control group (6 boys, 13 girls) that participated in traditional PE. The INT was performed 2 times per week during the first approximately 15 minutes of each PE class and consisted of body weight exercises. Push-up, curl-up, standing long jump, single-legged hop, single-legged balance, sit-and-reach flexibility test, shuttle run, and 0.8-km run. At baseline, the boys demonstrated higher levels of performance in most of the fitness measurements as evidenced by greater performance on the push-up, standing long jump, single-legged hop, shuttle run, and 0.8-km run (P < .05). In the evaluation of the training effects, we found intervention effects in the girls for enhanced INT-induced gains in performance relative to the control group on the curl-up, long jump, single-legged hop, and 0.8-km run (P < .05) after controlling for baseline. Boys did not demonstrate similar adaptations from the INT program (P ≥ .05). These data indicate that INT is an effective and time-efficient addition to PE for enhancing motor skills and promoting physical activity in children. Seven-year-old girls appeared to be more sensitive to the effects of INT than 7-year-old boys. Future research is warranted to confirm these effects in larger cohorts of children.

High-Power Testing of 11.424-GHz Dielectric-Loaded Accelerating Structures

NASA Astrophysics Data System (ADS)

Gold, Steven; Gai, Wei

2001-10-01

Argonne National Laboratory has previously described the design, construction, and bench testing of an X-band traveling-wave accelerating structure loaded with a permittivity=20 dielectric (P. Zou et al., Rev. Sci. Instrum. 71, 2301, 2000.). We describe a new program to build a test accelerator using this structure. The accelerator will be powered by the high-power 11.424-GHz radiation from the magnicon facility at the Naval Research Laboratory ( O.A. Nezhevenko et al., Proc. PAC 2001, in press). The magnicon is expected to provide up to 30 MW from each of two WR-90 output waveguide arms in pulses of up to 1 microsecond duration, permitting tests up to a gradient of 40 MV/m. Still higher power pulses (100-500 MW) may be available at the output of an active pulse compressor driven by the magnicon ( A.L. Vikharev et al., Proc. 9th Workshop on Advanced Accelerator Concepts.).

Oxidation Protection Systems for Carbon-Carbon Composites Formed by Chemical Vapor Deposition and Plasma Assisted Chemical Vapor Deposition Techniques

DTIC Science & Technology

1992-04-22

Illinois University at Carbondale, 1991, in printing. I 42. E. Tatarzycki, ABS Report-4538216:#3, 10, 1990. 43. C. Ju, et. al., Proc. of 6th Materials...transducer, ie. a more positive scaleI I 34 thickness of fairly continuous conversion layer carbon 10 , •O.0000 resina 0 0 Fiber O0c00.a 0 Bundlea • 06...at 13000C, 0.1 atm. 1 93 IZ- ... an rI pia irgaho tea-ccv~ ab .. au .re ;--24- Oo. C:caI micrograpt~h ofcin th e csr ossivc sczrbc2 ccirzza Fck

Factors affecting the output pulse flatness of the linear transformer driver cavity systems with 5th harmonics

DOE PAGES

Alexeenko, V. M.; Mazarakis, M. G.; Kim, A. A.; ...

2016-09-19

Here, we describe the study we have undertaken to evaluate the effect of component tolerances in obtaining a voltage output flat top for a linear transformer driver (LTD) cavity containing 3rd and 5th harmonic bricks [A. A. Kim et al., in Proc. IEEE Pulsed Power and Plasma Science PPPS2013 (San Francisco, California, USA, 2013), pp. 1354–1356.] and for 30 cavity voltage adder. Our goal was to define the necessary component value precision in order to obtain a voltage output flat top with no more than ±0.5% amplitude variation.

Factors affecting the output pulse flatness of the linear transformer driver cavity systems with 5th harmonics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Alexeenko, V. M.; Mazarakis, M. G.; Kim, A. A.

Here, we describe the study we have undertaken to evaluate the effect of component tolerances in obtaining a voltage output flat top for a linear transformer driver (LTD) cavity containing 3rd and 5th harmonic bricks [A. A. Kim et al., in Proc. IEEE Pulsed Power and Plasma Science PPPS2013 (San Francisco, California, USA, 2013), pp. 1354–1356.] and for 30 cavity voltage adder. Our goal was to define the necessary component value precision in order to obtain a voltage output flat top with no more than ±0.5% amplitude variation.

Air ambulance tasking: mechanism of injury, telephone interrogation or ambulance crew assessment?

PubMed

Wilmer, Ian; Chalk, Graham; Davies, Gareth Edward; Weaver, Anne Elizabeth; Lockey, David John

2015-10-01

The identification of serious injury is critical to the tasking of air ambulances. London's Air Ambulance (LAA) is dispatched by a flight paramedic based on mechanism of injury (MOI), paramedical interrogation of caller (INT) or land ambulance crew request (REQ).This study aimed to demonstrate which of the dispatch methods was most effective (in accuracy and time) in identifying patients with serious injury. A retrospective review of 3 years of data (to December 2010) was undertaken. Appropriate dispatch was defined as the requirement for LAA to escort the patient to hospital or for resuscitation on-scene. Inaccurate dispatch was where LAA was cancelled or left the patient in the care of the land ambulance crew. The χ(2) test was used to calculate p values; with significance adjusted to account for multiple testing. There were 2203 helicopter activations analysed: MOI 18.9% (n=417), INT 62.4% (n=1375) and REQ 18.7% (n=411). Appropriate dispatch rates were MOI 58.7% (245/417), INT 69.7% (959/1375) and REQ 72.2% (297/411). INT and REQ were both significantly more accurate than MOI (p<0.0001). There was no significant difference in accuracy between INT and REQ (p=0.36). Combining MOI and INT remotely identified 80.2% of patients, with an overtriage rate of 32.8%. Mean time to dispatch (in minutes) was MOI 4, INT 8 and REQ 21. Telephone interrogation of the caller by a flight paramedic is as accurate as ground ambulance crew requests, and both are significantly better than MOI in identifying serious injury. Overtriage remains an issue with all methods. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Advances in Acoustic Landmine Detection

DTIC Science & Technology

2006-10-01

8] A. Petculescu and J. M. Sabatier, “ Feasibility study of an air - coupled acoustic sensor for measuring small vibrations, Proc. SPIE 17th...the acoustic-to-seismic (A/S) coupling of airborne sound into the ground for buried anti-personnel and anti-tank landmine detection is well established...113, pp.1333-1341 (2003)]. A sound source is used to insonify the ground surface. The airborne sound couples into the soil and excites the

An Overview of MSHN: The Management System for Heterogeneous Networks

DTIC Science & Technology

1999-04-01

An Overview of MSHN: The Management System for Heterogeneous Networks Debra A. Hensgen†, Taylor Kidd†, David St. John§, Matthew C . Schnaidt†, Howard...ABSTRACT UU 18. NUMBER OF PAGES 15 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c . THIS PAGE...Alhusaini, V. K. Prasanna, and C . S. Raghavendra, “A unified resource scheduling framework for heterogeneous computing environments,” Proc. 8th IEEE

Switched Systems With Multiple Invariant Sets

DTIC Science & Technology

2015-05-06

LaSalle’s invariant set theorem [10] allow us to analyze asymptotic stability of this larger class of systems . LaSalle’s theorem and much of the... Stability and conver- gence for systems with switching equilibria, in: Proc. of the 46th IEEE Conference on Decision and Control , 2007. [8] X. Xu, G...Champaign, Urbana, Illinois 61801 Abstract This paper explores dwell time constraints on switched systems with mul- tiple, possibly disparate

Programmable Relations for Managing Change During Software Development

DTIC Science & Technology

1988-09-15

POSTGRES [37], in which attributes of relations can include abstract data types, although not other relations. POSTGRES [39] also includes other...that programmability of this type is missing from both POSTGRES and ALGRES. Nevertheless, programmable implementations are not mutually incompatible...December 1975. [37] L. A. Rowe and Michael R. Stonebraker. "The POSTGRES Data Model". In Proc. of the 13th VLDB Conference, pages 83-96, 1987. [38

Electron temperature response to ECRH on FTU tokamak in transient conditions.

NASA Astrophysics Data System (ADS)

Jacchia, A.; Bruschi, A.; Cirant, S.; Granucci, G.; Sozzi, C.; de Luca, F.; Amadeo, P.; Bracco, G.; Tudisco, O.

2001-10-01

Steady-state electron heat transport analysis of FTU high density plasmas under Electron Cyclotron Heating (ECRH) shows "stiff" electron temperature profiles [1,2,3]. Plasma response to off-axis EC heating, in fact, exibits a lower limit to electron temperature gradient length, Lc , below which electron thermal conductivity switches to higher values. Stiffness, however, is attenuated in the plasma core of saw-tooth free discharges with flat-hollow temperature profile and during current ramp-up [3,4,5], in which cases the temperature gradient length can be brought to very low values by means of on-axis ECH. Steady and current ramp-up discharges probed by steady and modulated ECH are analyzed in terms of stiffnes. Critical gradient length dependence on local features of computed current density profile is discussed. [1] Sozzi, C. et al., Paper EXP5/13, Plasma Phys. Contr. Fus. Res., Proc.18th IAEA Conf., Sorrento, 2000. [2] Jacchia, A. et al. Topical Conference on Radio Frequency Power in Plasmas, Oxnard, USA, (2001). [3] Cirant, S. et al. Topical Conference on Radio Frequency Power in Plasmas, Oxnard, USA, (2001). [4] Sozzi, C. et al., EPS, Madeira 2001. [5] Bracco, G. et al.,Plasma Phys. Contr. Fus. Res., Proc.18th IAEA Conf., Sorrento, 2000.

User’s Manual for the Screen Program.

DTIC Science & Technology

1980-05-01

j3* allows one to ch-’nje the sensor li~bel. It there is no sensor with the indiexpdseso numbgr, the projram w~ill porn ovit of this E N Th’P K !Y ( 14...r i hd in Cante r I II. ELL2~a~e__~J._L~9 t fn USflei ond, the l15cr is; )ro-inte I to prov 1d0 th1)e i n p, ts iiecessary to cons)triict one. The fir

Modeling interchild differences in pharmacokinetics on the basis of subject-specific data on physiology and hepatic CYP2E1 levels: A case study with toluene

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nong, A.; McCarver, D.G.; Hines, R.N.

2006-07-01

The objective of the present study was to evaluate the magnitude of interindividual variability in the internal dose of toluene in children of various age groups, on the basis of subject-specific hepatic CYP2E1 content and physiology. The methodology involved the use of a previously validated physiologically based pharmacokinetic (PBPK) model, in which the intrinsic clearance for hepatic metabolism (CL{sub int}) was expressed in terms of the CYP2E1 content. The adult toluene PBPK model, with enzyme content-normalized CL{sub int}, facilitated the calculation of child-specific CL{sub int} based on knowledge of hepatic CYP2E1 protein levels. The child-specific physiological parameters, except liver volume,more » were computed with knowledge of age and body weight, whereas physicochemical parameters for toluene were kept age-invariant based on available data. The actual individual-specific liver volume (autopsy data) was also included in the model. The resulting model was used to simulate the blood concentration profiles in children exposed by inhalation, to 1 ppm toluene for 24 h. For this exposure scenario, the area under the venous blood concentration vs. time curve (AUC) ranged from 0.30 to 1.01 {mu}g/ml x h in neonates with low CYP2E1 concentration (<3.69 pmol/mg protein). The simulations indicated that neonates with higher levels of CYP2E1 (4.33 to 55.93 pmol/mg protein) as well as older children would have lower AUC (0.16 to 0.43 {mu}g/ml x h). The latter values were closer to those simulated for adults. Similar results were also obtained for 7 h exposure to 17 ppm toluene, a scenario previously evaluated in human volunteers. The interindividual variability factor for each subgroup of children and adults, calculated as the ratio of the 95th and 50th percentile values of AUC, was within a factor of 2. The 95th percentile value of the low metabolizing neonate group, however, was greater than the mean adult AUC by a factor of 3.9. This study demonstrates the feasibility of incorporating subject-specific data on hepatic CYP2E1 content and physiology within PBPK models for evaluating the age, interchild and population variability of internal dose for use in risk assessment of inhaled volatile organics.« less

75 FR 61757 - Ocean Transportation Intermediary License Applicants

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-06

... Cargo Corp. (NVO & OFF), 8430 N.W. 66th Street, Miami, FL 33166. Officers: Karime Zawady, Vice President...), Jinho Um, CFO. Application Type: New NVO & OFF License. Junction Int'l Logistics, Inc. (NVO), 17870 Castleton Street, Suite 107, City of Industry, CA 91748. Officers: Charles Kuo, Secretary (Qualifying...

Spectral evolution and extreme value analysis of non-linear numerical simulations of narrow band random surface gravity waves.

NASA Astrophysics Data System (ADS)

Socquet-Juglard, H.; Dysthe, K. B.; Trulsen, K.; Liu, J.; Krogstad, H. E.

2003-04-01

Numerical simulations of a narrow band gaussian spectrum of random surface gravity waves have been carried out in two and three spatial dimensions [7]. Different types of non-linear Schr&{uml;o}dinger equations, [1] and [4], have been used in these simulations. Simulations have now been carried with a JONSWAP spectrum associated with a spreading function of the type cosine-squared [5]. The evolution of the spectrum, skewness, kurtosis, ... will be presented. In addition, some results about stochastic properties of the surface will be shown. Based on the approach found in [2], [3] and [6], the results are presented in terms of deviations from linear Gaussian theory and the standard second order small slope perturbation theory. begin{thebibliography}{9} bibitem{kk96} Trulsen, K. &Dysthe, K. B. (1996). A modified nonlinear Schr&{uml;o}dinger equation for broader bandwidth gravity waves on deep water. Wave Motion, 24, pp. 281-289. bibitem{BK2000} Krogstad, H.E. and S.F. Barstow (2000). A uniform approach to extreme value analysis of ocean waves, Proc. ISOPE'2000, Seattle, USA, 3, pp. 103-108. bibitem{PRK} Prevosto, M., H. E. Krogstad and A. Robin (2000). Probability distributions for maximum wave and crest heights, Coast. Eng., 40, 329-360. bibitem{ketal} Trulsen, K., Kliakhandler, I., Dysthe, K. B. &Velarde, M. G. (2000) On weakly nonlinear modulation of waves on deep water, Phys. Fluids, 12, pp. L25-L28. bibitem{onorato} Onorato, M., Osborne, A.R. and Serio, M. (2002) Extreme wave events in directional, random oceanic sea states, Phys. Fluids, 14, pp. 2432-2437. bibitem{BK2002} Krogstad, H.E. and S.F. Barstow (2002). Analysis and Applications of Second Order Models for the Maximum Crest height, % Proc. 21nd Int. Conf. Offshore Mechanics and Arctic Engineering, Oslo. Paper no. OMAE2002-28479. bibitem{JFMP} Dysthe, K. B., Trulsen, K., Krogstad, H. E. and Socquet-Juglard, H. (2002, in press) Evolution of a narrow band spectrum of random surface gravity waves, J. Fluid Mech.

Development of Gravidynamical Equations for a Weakly Gravitating Body in the Vicinity of Absolute Zero Temperature

NASA Astrophysics Data System (ADS)

Krot, Alexander M.

2002-01-01

the framework of this model bodies have fuzzy outlines and are represented by means of spheroidal forms. The consistency of the statistical model with the Einstein general relativity3,4,5 has been shown. In the work6, which is a continuation of the paper2, it was investigated a slowly evolving in time process of a gravitational compression (contraction) of a spheroidal body close to an unstable meñhanical equilibrium state (a low mass flow), therefore the process of the gravitational contraction appears slowly developing in time (the case of unobservable velocities of particles composing a spheroidal body). For this case in the work7 it has been shown that the strength and potential of the gravitational field of a slowly contracting spheroidal body satisfy a differential equation of the second order of the parabolic type for the case of unobservable velocities of particles. Therefore gravitational waves of a soliton type are propagated in a weakly gravitating spheroidal body if values of velocities are unobservable. body. In the connection with the above-given statements, in the present paper the following assumptions are used: 1.The spheroidal body under consideration is homogeneous in its chemical structure, i.e. it consists of identical particles with the mass m0. 2.The spheroidal body is not subjected to influence of external fields and bodies. 3.The spheroidal body is isothermal and has temperature close to the absolute zero. 4.The concentration gradient is not too large in the sense that interphase boundaries are absent inside the spheroidal body. 5. In view of low values of the temperature the heat conduction and viscosity processes are not important, which allows to describe the rotation of the spheroidal body as a whole, while movement of flows of particles inside the weakly gravitating spheroidal body is modeled by means of a motion of an ideal medium (the case of observable velocities of particles). 6.Since the process of the gravitational compression (contraction) of the spheroidal body is weak and viscosity is absent, we regard the motion of the continuous medium to be non-turbulent. modeled by means of an ideal liquid. It is determined the connection of this equation with an equation of motion of a particle in a noninertial frame of reference. A gravimagnetic field is introduced in this paper. It is obtained the scalar and vector potentials as well as the Lagrange function of a particle moving in a gravitational and gravimagnetic fields. It is derived the equations of hyperbolic type for the gravitational field of a weakly gravitating spheroidal body under observable values of velocities of particles composing it. 1. A.M.Krot, Achievements in Modern Radioelectronics, special issue "Cosmic Radiophysics", no.8, pp.66- 2. A.M.Krot, Proc. SPIE 13th Symp."AeroSense", Orlando, Florida, April 5-9,1999, vol.3710,pp.1248-1259. 3. L.D.Landau and E.M.Lifshitz, Classical Theory of Fields, Addison-Wesley, 1951. 4. S.Weinberg, Gravitation and Cosmology, John Wiley and Sons, New York, 1972. 5. C.W.Misner, K.S.Thorne, and J.A.Wheeler, Gravitation, W.H.Freeman and Co., San Francisco, 1973. 6. A.M.Krot, Proc. SPIE 14th Symp."AeroSense",Orlando,Florida,April 24-28,2000,vol.4038,pp.1318-1329. 7. A.M.Krot, Proc. SPIE 15th Symp."AeroSense",Orlando,Florida,April 16-20,2001,vol.4394,pp.1271-1282.

Real Scan Evolution.

DTIC Science & Technology

1982-02-01

I -TREF OELJ =J -PE nTST = SIRT (DELI*DEr4 I + DELJ*DELUJ) IDIST = n1ST COLOR = IDIST/2 [7ICURN.E0).1) COLOR =256 - IDISr/2 IF(COr-IR.LT.0) COLOR = 0...C4,t OPC 𔃾K EN!)TF * C TiPE*,’PASS’,IR9PPT,’CO’PtrD’ 9999 C IN1T 1 . 119 G)TD 500 130 TfPE*t ’tNITtLIZE CI)LOfR: NFUIRAL=O, COLOR3’ ACCEPT*f NCOLMl...INTE:RVAL. SIRPTS= SIRT (PlTNTS) !CALAIrON 3F~ DPTIEN EN*SIJRES A IPICSM4P=PICWIT*DPAC !C~ThSIA-,vT NUM4ER OF INTERPOLATED IF(IPICSMP.LT.1) G0T1) 400 !REQUIRED

The Shock and Vibration Digest, Volume 18, Number 3

DTIC Science & Technology

1986-03-01

Linear Distributed Parameter Des., Proc. Intl. Symp., 11th ONR Naval Struc. Systems by Shifted Legendre Polynomial Func- Mech. Symp., Tucson, AZ, pp...University, Atlanta, Georgia nonlinear problems with elementary algebra . It J. Sound Vib., 102 (2), pp 247-257 (Sept 22, uses i = -1, the Pascal’s...eigenvalues specified. The optimal avoid failure due to resonance under the action control problem of a linear distributed parameter 0School of Mechanical

Hierarchical Organization for Large, Dynamic Radio Networks.

DTIC Science & Technology

1988-01-01

January 1985. [3] N. Shacharm and J. Tornow . Future Directions in Packet Radio Technology. In - Proc. of IEEE INFOCOM󈨙, Washington, D.C., 1985. [4] J.J...Freeman and Company, 1979. [7] J. Jubin and J. Tornow . The DARPA Packet Radio Network Protocols. Proceed- inga of the IEEE, 75(1):21-32, January 1987... Tornow . Future Directions in Packet Radio Technology. In Proc. of IEEE INFOCOM󈨙, Washington, D.C., 1985. [28] N. Shacham and J. Westcott. Future

The Lunar dusty plasmas -levitation and transport.

NASA Astrophysics Data System (ADS)

Atamaniuk, Barbara; Rothkaehl, Hanna

Lunar dust can exhibit unusual behavior -due to electron photoemission via solar-UV radiation the lunar surface represents a complex plasma -"dusty plasma". The dust grains and lunar surface are electrostatically charged by the Moon's interaction with the local plasma environ-ment and the photoemission of electrons due to solar UV and X-rays. This effect causes the like-charged surface and dust particles to repel each other, and creates a near-surface electric field. Lunar dust must be treated as a dusty plasma. Using analytic (kinetic (Vlasov) and magnetohydrodynamic theory ) and numerical modeling we show physical processes related to levitation and transport dusty plasma on the Moon. These dust grains could affect the lunar environment for radio wave and plasma diagnostics and interfere with exploration activities. References: 1. Wilson T.L. (1992), in Analysis of Interplanetary Dust, M. Zolensky et al. AIP Conf.Proc. 310, 33-44 (AIP, NY), 2.Wilson T.L."LUNAR DUST AND DUSTY PLASMA PHYSICS".40th Lunar and Planetary Science Conference (2009), 3. Grün E., et al.(1993),Nature 363, 144. 4. Morfill G. and Grün E.(1979), Planet. Space Sci.. 27, 1269, 1283, 5. Manka R. and Michel F. (1971), Proc. 2nd Lun. Sci. Conf. 2, 1717 (MIT Press, Cambridge). 6. Manka R. et al.(1973), Lun. Sci.-III, 504. 7. Barbara Atamaniuk "Kinetic Description of Localized Plasma Structure in Dusty Plasmas". Czechoslovak Journal of Physics Vol.54 C 2004

Class 2 Integrons Dissemination Among Multidrug Resistance (MDR) Clones of Acinetobacter baumannii

PubMed Central

Ramírez, María Soledad; Morales, Amanda; Vilacoba, Elisabet; Márquez, Carolina

2014-01-01

Acinetobacter baumannii has emerged as a serious problem in the hospital environment at a global scale. Previous results from our laboratory showed a high frequency of class 2 integrons in A. baumannii strains from Argentina regarding the low rate of this element in A. baumannii isolates from the rest of the world. To reveal the current epidemiology of class 2 integrons, a molecular surveillance analyzing 78 multidrug resistant (MDR) A. baumannii isolates from Argentina and Uruguay was performed, exposing the presence of class 2 integron in the 36.61% of the isolates. Class 2 integron characterization showed that the typical Tn7::In2-7 array was present in 26 out of 27 intI2 positive isolates. All intI2 positive isolates contained at least one of the Tn7 transposition genes. In addition, we identified that 18 intI2 positive isolates possessed the Tn7::In2-7 within the attTn7 site. The molecular typing evidenced that clones I and IV that do not belong to widespread European clones I and II were found among the intI2 positive isolates. Our results exposed the widely dissemination of class 2 integron among MDR A. baumannii isolates from Argentina and Uruguay, also showing the persistence of two novel clones in our region, which could explain in part the high frequency of class 2 integron found in our region. PMID:22198473

Characterization of in vitro glucuronidation clearance of a range of drugs in human kidney microsomes: comparison with liver and intestinal glucuronidation and impact of albumin.

PubMed

Gill, Katherine L; Houston, J Brian; Galetin, Aleksandra

2012-04-01

Previous studies have shown the importance of the addition of albumin for characterization of hepatic glucuronidation in vitro; however, no reports exist on the effects of albumin on renal or intestinal microsomal glucuronidation assays. This study characterized glucuronidation clearance (CL(int, UGT)) in human kidney, liver, and intestinal microsomes in the presence and absence of bovine serum albumin (BSA) for seven drugs with differential UDP-glucuronosyltransferase (UGT) 1A9 and UGT2B7 specificity, namely, diclofenac, ezetimibe, gemfibrozil, mycophenolic acid, naloxone, propofol, and telmisartan. The impact of renal CL(int, UGT) on accuracy of in vitro-in vivo extrapolation (IVIVE) of glucuronidation clearance was investigated. Inclusion of 1% BSA for acidic drugs and 2% for bases/neutral drugs in incubations was found to be suitable for characterization of CL(int, UGT) in different tissues. Although BSA increased CL(int, UGT) in all tissues, the extent was tissue- and drug-dependent. Scaled CL(int, UGT) in the presence of BSA ranged from 2.22 to 207, 0.439 to 24.4, and 0.292 to 23.8 ml · min(-1) · g tissue(-1) in liver, kidney, and intestinal microsomes. Renal CL(int, UGT) (per gram of tissue) was up to 2-fold higher in comparison with that for liver for UGT1A9 substrates; in contrast, CL(int, UGT) for UGT2B7 substrates represented approximately one-third of hepatic estimates. Scaled renal CL(int, UGT) (in the presence of BSA) was up to 30-fold higher than intestinal glucuronidation for the drugs investigated. Use of in vitro data obtained in the presence of BSA and inclusion of renal clearance improved the IVIVE of glucuronidation clearance, with 50% of drugs predicted within 2-fold of observed values. Characterization and consideration of kidney CL(int, UGT) is particularly important for UGT1A9 substrates.

Wireless Sensor Node Data Gathering and Location Mapping

DTIC Science & Technology

2012-03-01

adaptive two-phase approach to WiFi location sensing,” 4 th Int. Conf. on Pervasive Computing and Communications Workshops, Pisa, Italy, 2006, pp. 452...wrt.v24_micro_generic.bin, March 2010. [11] P. Asadoorian and L. Pesce, Linksys WRT54G Ultimate Hacking , Burlington, MA: Syngress, 2007, pp. 25. 32

A Guide to Electrical Insulation Design in Aerospace Vehicles for a Broad Range of Environmental Parameter Space

DTIC Science & Technology

2010-03-01

as an example with information from Llewellyn Jones (1939) [30] and from Meek (1978), pg. 233 [7]. Morokuma (1969) [31] varied the surface potential...breakdown in high pressure gases,” Phys. Rev. A, 21, 2069. 13. Dutton, J., Llewellyn Jones , F., and Palmer, R.W., (1961), Proc. Phys. Soc. 78, 569...breakdown and insulators in compressed gas,” IEE Proc. 128, 303. 30. Llewellyn Jones , F. (1939), Phil. Mag. 28, 192. 31. Morokuma, Y., Nakamura, Y., and

Lower rate-pressure product during submaximal walking: a link to fatigue improvement following a physical activity intervention among breast cancer survivors.

PubMed

Carter, Stephen J; Hunter, Gary R; McAuley, Edward; Courneya, Kerry S; Anton, Philip M; Rogers, Laura Q

2016-10-01

Research showing a link between exercise-induced changes in aerobic fitness and reduced fatigue after a cancer diagnosis has been inconsistent. We evaluated associations of fatigue and rate-pressure product (RPP), a reliable index of myocardial oxygen demand, at rest and during submaximal walking following a physical activity intervention among post-primary treatment breast cancer survivors (BCS). Secondary analyses of 152 BCS in a randomized controlled trial testing a physical activity intervention (INT) versus usual care (UC) were performed. The INT group completed counseling/group discussions along with supervised exercise sessions tapered to unsupervised exercise. Evaluations were made at baseline and immediately post-intervention (M3) on measures of physical activity (accelerometry), graded walk test, and average fatigue over the previous 7 days. RPP was calculated by dividing the product of heart rate and systolic blood pressure by 100. Resting and submaximal RPPs were significantly improved in both groups at M3; however, the magnitude of change (∆) was greater in the INT group from stage 1 (∆RPP1; INT -13 ± 17 vs. UC -7 ± 18; p = 0.03) through stage 4 (∆RPP4; INT -21 ± 26 vs. UC -9 ± 24; p < 0.01) of the walk test. The INT group reported significantly reduced fatigue (INT -0.7 ± 2.0 vs. UC +0.1 ± 2.0; p = 0.02) which was positively associated with ∆RPP during stages 2-4 of the walk test but not ∆aerobic fitness. Lower RPP during submaximal walking was significantly associated with reduced fatigue in BCS. Exercise/physical activity training programs that lower the physiological strain during submaximal walking may produce the largest improvements in reported fatigue.

Testing Methods for Integrated Circuit Chips.

DTIC Science & Technology

1986-03-27

DWf <I IAV ~IMi MORY OUT LOGIC~~ IPOGRAM ASYC S’E4i E...* 16o, CO% T ROL CO%TROL 32 Figure 2 . 14 VLSI Tester Block Diagram. registers, memory and test...neral-pIurpos’ processor wi th standard bus- inte-rfaco se-rves as,- th- test control Ii’r and ( 2 ) a c-ustom VLSI test Controller inti-rfacing direc(_t1...Engineering 2 WTWTY ABSTRACT Provision for the functional testing of fabricated VLSI chips frequently involves as much design effort as the orig- _ inal

16TH Annual Review of Progress in Applied Computational Electromagnetics at the Naval Postgraduate School Monterey, CA, March 20-24, 2000, Volume II

DTIC Science & Technology

2000-03-24

34, Proceedings of the 4th Int. Conf. on Computer-Aided Drafting, Design and Manufacturing Technology, Bejing , China , pp. 133-139, aug 1994. [4] C. J. Hsu...transmission and reflec- warped gyro-frequency. The prewarping opera - tion performance of a magnetized plasma slab tion conserves the d.c. gain and the...inverse NUDFT’s are obtained efficiently by the NUFFT algorithms with O(N log2 N) arithmetic opera - tions. Therefore the CG-NUFFT retains the

Three-dimensional kinematic analysis and power output of elite flat-water kayakers.

PubMed

Bjerkefors, Anna; Tarassova, Olga; Rosén, Johanna S; Zakaria, Pascal; Arndt, Anton

2017-09-20

The purpose was to examine power output and three-dimensional (3D) kinematic variables in the upper limbs, lower limbs and trunk in elite flat-water kayakers during kayak ergometer paddling. An additional purpose was to analyse possible changes in kinematics with increased intensity and differences between body sides. Six male and four female international level flat-water kayakers participated. Kinematic and kinetic data were collected during three tasks; low (Int L ), high (Int H ) and maximal (Int M ) intensities. No differences were observed in any joint angles between body sides, except for shoulder abduction. Significantly greater range of motion (RoM) values were observed for Int H compared to Int L and for Int M compared to Int L in trunk and pelvis rotation, and in hip, knee and ankle flexion. The mean maximal power output was 610 ± 65 and 359 ± 33 W for the male and female athletes, respectively. The stroke frequencies were significantly different between all intensities (Int L 59.3 ± 6.3; Int H 108.0 ± 6.8; Int M 141.7 ± 18.4 strokes/min). The results showed that after a certain intensity level, the power output must be increased by other factors than increasing the joint angular RoM. This information may assist coaches and athletes to understand the relationship between the movement of the kayaker and the paddling power output.

Evaluation of corrosion resistance and surface characteristics of orthodontic wires immersed in different mouthwashes.

PubMed

Nalbantgil, Didem; Ulkur, Feyza; Kardas, Gulfeza; Culha, Mustafa

2016-11-25

Patients use mouthwashes in addition to mechanical cleaning during orthodontic treatment. The effects of mouthwashes on the archwires have not been examined yet. To compare the corrosion resistance of four different arch wires and corrosion effects of different mouthwashes to formulate a biocompatible and mechanically useful arch wire and mouthwash combination. Each group comprised of 4 wire samples of 2 cm 0.016 × 0.022 inch. 1st group: ion implanted nickel titanium (INT), 2nd group: nickel titanium, without ion implantation (NT), 3rd group: micro layered esthetic nickel titanium (ENT), 4th group: stainless steel (SS) wires. They were immersed inside 2 ml of artificial saliva solutions (AS) for the control, or AS (9%) combined with 1 of the 3 mouthwashes (91%) for study groups, for 24 hours. These mouthwashes were essential oil (EO), chlorhexidine (CHX), sodium-fluoride (NaF). An electrochemical analyzer was used for electrochemical impedance spectroscopy measurements. High corrosion resistance was obtained for ENT than the other wires. The corrosion potentials are 0.007, -0.042, 0.074 and -0.015 V (Ag/AgCl) for ENT, INT, SS and NT in the artificial salivary, respectively. In NaF containing mouthwash Rp value of ENT is significantly high in comparison to others. The impedance responses of all materials increased significantly in the presence of NaF mouthwash as well as in the CHX mouthwash. Low frequencies are seen at all materials in EO mouthwash. Diameters of loops are 22, 5.9, 5.9 and 3.7 MΩ at ENT, INT, SS and NT. In this study, micro layered esthetic nickel titanium wires are found biocompatible among other wires and NaF and CHX mouthwashes can be recommend for their good corrosion resistance during fixed orthodontic therapy.

Lift-Off Performance in Flexure Pivot Pad and Hybrid Bearings

DTIC Science & Technology

2008-12-01

and Dawson, M. P., 1998, "Experience in the Use of Flexure Pivot Tilt Pad Bearings in Boiler Feed Water Pumps ," Proc. of the 15th International...freely. Test Procedure 1) Turn on the pump to buffer water to the test bearing. 2) Turn on air to the air seal that prevents water flowing... Pump Users Symposium, Turbomachinery Laboratory, College Station, Texas, pp. 77-84. [6] Rodriguez, L., 2004, “Experimental Frequency-Dependent

Application of an Imaging Fourier-Transform Spectrometer for the Means of Combustion Diagnostics

DTIC Science & Technology

2012-06-14

and P. McCready. Dial measurements of fugitive emissions from natural gas plants and the comparison with emission factor estimates. Proc. 15th...12-J02 Abstract A passive remote sensing technique for accurately monitoring the combustion effi- ciency of petrochemical flares is greatly desired. A...and the spatial distribu- tion of combustion by-products. The flame spectra were characterized by structured emissions from CO2, H2O and CO

Transformation of Waves Across the Surf Zone.

DTIC Science & Technology

1981-03-01

Kuo is more realis- tic but still results in a sharp cut-off of the distribution at the breaking heights. 5. Goda Distribution Goda (1975) derived a...J.I., "Probabilities of Breaking Wave Characteris- tics ," Proc. 12th Coastal Engineering Conf., pp. 399- 412, 1970. Chakrabarty, S.K. and R.P. Cooley...Spring, MD 20910 21. Director 2 Instituto Oceanografico de la Armada Guayaquil, Ecuador 22. Director de Educacion de la Armada Comandancia General de

On Generalizations of Cochran’s Theorem and Projection Matrices.

DTIC Science & Technology

1980-08-01

Definiteness of the Estimated Dispersion Matrix in a Multivariate Linear Model ," F. Pukelsheim and George P.H. Styan, May 1978. TECHNICAL REPORTS...with applications to the analysis of covariance," Proc. Cambridge Philos. Soc., 30, pp. 178-191. Graybill , F. A. and Marsaglia, G. (1957...34Idempotent matrices and quad- ratic forms in the general linear hypothesis," Ann. Math. Statist., 28, pp. 678-686. Greub, W. (1975). Linear Algebra (4th ed

AQMEII3: the EU and NA regional scale program of the Hemispheric Trasport of Air Pollution Task Force

EPA Science Inventory

The presentation builds on the work presented last year at the 14th CMAS meeting and it is applied to the work performed in the context of the AQMEII-HTAP collaboration. The analysis is conducted within the framework of the third phase of AQMEII (Air Quality Model Evaluation Inte...

Scaling of the VASIMR thruster first stage operation

NASA Astrophysics Data System (ADS)

Molvig, Kim; Batishchev, Oleg

2002-11-01

An effective helicon plasma source [1,2] is used in the variable high specific impulse VASIMR plasma thruster [3]. Experimental prototypes - VX-3 and recently up-scaled VX-10 [4] configurations operate with hydrogen, deuterium and helium plasmas. A set of models [5-7] has been developed to study VASIMR light gases helicon discharge. Using zero-dimensional model incorporating energy and mass balance equations we study scaling of the plasma source efficiency with the increased mass flow rate, applied electrical power and dimensions of the quartz tube. We compare theoretical results with existing experimental data. [1] M.A.Lieberman, A.J.Lihtenberg, 'Principles of ..', Wiley, 1994; [2] F.F.Chen, Plas. Phys. Contr. Fus. 33, 339, 1991; [3] F.Chang-Diaz et al, Bull. APS 45 (7) 129, 2000; [4] J.Squire et al., Bull. APS 45 (7) 130, 2000; [5] O.Batishchev, K.Molvig, AIAA technical paper 2000-3754, 2001; [6] O.Batishchev, K.Molvig, IEPC-01-208 paper, 27th Int. Electrical Propulsion Conf., 2001; [7] O.Batishchev, K.Molvig, AIAA technical paper 2002-0347, 2002.

Continuous and interval training programs using deep water running improves functional fitness and blood pressure in the older adults.

PubMed

Reichert, Thaís; Kanitz, Ana Carolina; Delevatti, Rodrigo Sudatti; Bagatini, Natália Carvalho; Barroso, Bruna Machado; Kruel, Luiz Fernando Martins

2016-02-01

This study aimed to investigate the effects of two periodized training programs of deep water running on functional fitness and blood pressure in the older adults. Thirty-six individuals were divided into continuous group (CONT) and interval group (INT). Both groups were trained for 28 weeks (twice weekly). Measures were performed before the training period, after 12 weeks and training period. Two-way ANOVA and post hoc of Bonferroni were used (α = 0.05). There were no differences between groups in functional tests, with the exception of the flexibility of the upper limbs, in which the INT group showed the highest values. There was a significant improvement in both groups of foot up-and-go test (CONT 6.45 to 5.67; INT 6.59 to 5.78, in seconds), flexibility of lower limbs (CONT -4.76 to -0.61; INT 0.54 to 4.63, in centimeters), strength of upper (CONT 18.76 to 27.69; INT 18.66 to 26.58, in repetitions) and lower limbs (CONT 14.46 to 21.23; INT 14.40 to 21.58, in repetitions), and 6-min walk (CONT 567.50 to 591.16; INT 521.41 to 582.77, in meters). No differences were shown between groups for systolic blood pressure; however, diastolic blood pressure remained higher in CONT during all training. The blood pressure decreased significantly in both groups after the training (CONT 142 ± 16/88 ± 3 to 125 ± 14/77 ± 7 mmHg; INT 133 ± 15/75 ± 7 to 123 ± 17 and 69 ± 11 mmHg). Both programs of deep water running training promoted improvements of similar magnitude in all parameters of functional fitness, with the exception of flexibility of upper limbs, and decreased blood pressure in the older individuals.

Construction of even and odd combinations of Morse-like coherent states

NASA Astrophysics Data System (ADS)

Récamier, José; Jáuregui, Rocio

2003-06-01

In this work we construct approximate coherent states for the Morse potential using a method inspired by the f-oscillator formalism (Man'ko et al 1996 Proc. 4th Wigner Symp. ed M Natig, Atakishiyev, T H Seligman and K B Wolf (Singapore: World Scientific) p 421). We make even and odd combinations of these states and evaluate the temporal evolution of the position operator and its dispersion as a function of time when the states evolve under a nonlinear Morse Hamiltonian.

Thermal Relaxation Processes and Stability in Poled Electro-Optic Polymers

DTIC Science & Technology

1994-06-30

34, Gordon Research Conference on Dielectric Phenomena, Holderness School, NH July 31-August 5, 1994. 2. K.D. Singer, R. Dureiko, J. Khaydarov , and R...Fuerst, "Relaxation in Poled Electro- optic Polymers", 4th Iketani Conference, Hawaii, May 17-20, 1994. 3. J.H. Andrews, J.D.V. Khaydarov , and K.D. Singer...Dureiko, J. Khaydarov , and R. Fuerst, "Relaxation Phenomena in Poled Electro-Optic Polymers", Proc. Mat. Res. Soc. 328, 499 (1994). 5. R.A. Fuerst, "Thermal

Numerical Function Generators Using LUT Cascades

DTIC Science & Technology

2007-06-01

either algebraically (for example, sinðxÞ) or as a table of input/ output values. The user defines the numerical function by using the syntax of Scilab ...defined function in Scilab or specify it directly. Note that, by changing the parser of our system, any format can be used for the design entry. First...Methods for Multiple-Valued Input Address Generators,” Proc. 36th IEEE Int’l Symp. Multiple-Valued Logic (ISMVL ’06), May 2006. [29] Scilab 3.0, INRIA-ENPC

Proceedings of the International Symposium on Shock Tubes and Waves (12th) Held at Jerusalem on 16-19 July 1979.

DTIC Science & Technology

1980-02-01

is also gratefully acknowledged. REFERENCES 1. P.H. Azoury, An Introduction to the Dna-iic Pressure S&c-h’c:4 . Proc. Inst. Mech. Eng. 180, (Pt. 1...crosscorrelation parameters. Practical examples of the ap- plicability to flow fields and combustion diagnostics are presented. INTRODUCTION The appearance of the...laser and its introduction into the field of spec- troscopy was a turning point in the development of light scattering diagnostic techniques. In a

Exposure of Creosote-Naive and Creosote-Conditioned Limnoria tripunctata (Menzies) of Untreated and Creosote-Treated Wood.

DTIC Science & Technology

1983-06-13

contents, and within the space between the peritrophic membrane and the intestinal lining. Zachery and Colwell [24] and Emery [251 suggested that...seawater, each containing a piece of Whatman #42 filter paper as a food source. Those animals that did not appear to be healthy at the end of this...Parrish and .D. Bultman, "Navy reserach on marine borers and the laboratory culturing of limnorians," Proc. 4th Annual Combined MTS-IEEE Conference

An Assessment of Binary Metallic Glasses: Correlations Between Structure, Glass Forming Ability and Stability (Preprint)

DTIC Science & Technology

2009-04-01

Cu, germanium and tellurium ," J. Mat. Sci., vol. 9, pp. 707-717, 1974. [29] A. Inoue, T. Zhang, K. Kita, and T. Masumoto, "Mechanical strengths...Toribuchi, K. Aoki, and T. Masumoto, "Formation of La-M- Cu (M=Ca, Sr or Ba) amorphous alloys and their oxidization and superconductivity," Trans. JIM...structure of Pd- Ge alloys glasses by pulsed neutron total scattering," presented at Proc. 4 th International Conference on Rapidly Quenched Metals

Analysis of a Rapidly Solidified High-Phosphorus Austenitic Steel Containing an Amorphous Phase.

DTIC Science & Technology

1981-12-01

electrodeposited nickel by a combination of Jet electro- polishing and ion-beam milling. Specimens were observed in a Vacuum Generators HB-5 scanning...the cell walls in these powders is one of suppressed crystal growth rather than nucleation , since the glass is formed in direct contact with the...Cohen, this Symposium. 5. T. F. Kelly, Ph.D. Thesis , MIT, February 1982. 6. C. V. Thompson, A. L. Greer, and A. J. Drehman, Proc. 4th Intl. Conf

1997 International Semiconductor Device Research Symposium (4th) Proceedings, Held in Charlottesville, Virginia on December 10-13, 1997

DTIC Science & Technology

1998-01-01

Matagne1𔃼, Jean -Pierre Leburton1 Jacques Destine2, Guy Cantraine2 1Beckman Institute, University of Illinois at Urbana-Champaign , Urbana, IL 61820...PROCESSES R. Peter Smith, Suzanne C. Martin, Moonil Kim, Jean Bruston, Imran Mehdi, Dexter Humphrey, Michael Gaidis, Neal Erickson*, and Peter H...SEV/VSE, Feb. 1981 G. Galup-Montoro, M. Schneider, S. Acosta, R. Pinto , Proc. Brazilian Microelectronics Conference SBMICRO󈨤,1996. A. Cunha, O

Egocentric Depth Judgements in Optical, See-Through Augmented Reality

DTIC Science & Technology

2007-06-01

Gabbard , and D. Hix, “An Augmented Reality System for Military Operations in Urban Terrain,” Proc. Inter- service/Industry Training, Simulation...Education Conf. (I/ITSEC ’02), 2002. [20] M.A. Livingston, J.E. Swan II, J.L. Gabbard , T.H. Höllerer, D. Hix, S.J. Julier, Y. Baillot, and D. Brown...J.E. Swan II, M.A. Livingston, H.S. Smallman, D. Brown, Y. Baillot, J.L. Gabbard , and D. Hix, “A Perceptual Matching Technique for Depth Judgements in

Measuring Two-Event Structural Correlations on Graphs

DTIC Science & Technology

2012-08-01

2012 to 00-00-2012 4. TITLE AND SUBTITLE Measuring Two-Event Structural Correlations on Graphs 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ...by event simulation on the DBLP graph. Then we examine the efficiency and scala - bility of the framework with a Twitter network. The third part of...correlation pattern mining for large graphs. In Proc. of the 8th Workshop on Mining and Learning with Graphs, pages 119–126, 2010. [23] T. Smith. A

Evaluation of Commercial and Field-Expedient Baited Traps for House Flies, Musca domestica L. (Diptera: Muscidae)

DTIC Science & Technology

2009-01-09

Vector Ecology 34 (1): 99-103. 2009. Keyword Index : House fly, Musca domestica, trapping. INTRODUCTION Traps have been a mainstay of house fly (Musca...attract synanthropic flies. Proc. Pap. 46th Ann. Conf. Calif. Mosq. Vector Contr. Assoc. pp. 70-73. Pickens, L. G. and R. W. Miller. 1987. Techniques...1139: 279- 284. SAS Institute. 1992. SAS users guide: statistics. SAS Institute, Cary, NC. Warner, W. B. 1991. Attractant composition for synanthropic

Marine04 Marine radiocarbon age calibration, 26 ? 0 ka BP

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hughen, K; Baille, M; Bard, E

2004-11-01

New radiocarbon calibration curves, IntCal04 and Marine04, have been constructed and internationally ratified to replace the terrestrial and marine components of IntCal98. The new calibration datasets extend an additional 2000 years, from 0-26 ka cal BP (Before Present, 0 cal BP = AD 1950), and provide much higher resolution, greater precision and more detailed structure than IntCal98. For the Marine04 curve, dendrochronologically dated tree-ring samples, converted with a box-diffusion model to marine mixed-layer ages, cover the period from 0-10.5 ka cal BP. Beyond 10.5 ka cal BP, high-resolution marine data become available from foraminifera in varved sediments and U/Th-dated corals.more » The marine records are corrected with site-specific {sup 14}C reservoir age information to provide a single global marine mixed-layer calibration from 10.5-26.0 ka cal BP. A substantial enhancement relative to IntCal98 is the introduction of a random walk model, which takes into account the uncertainty in both the calendar age and the radiocarbon age to calculate the underlying calibration curve. The marine datasets and calibration curve for marine samples from the surface mixed layer (Marine04) are discussed here. The tree-ring datasets, sources of uncertainty, and regional offsets are presented in detail in a companion paper by Reimer et al.« less

Intermittent energy restriction improves weight loss efficiency in obese men: the MATADOR study

PubMed Central

Byrne, N M; Sainsbury, A; King, N A; Hills, A P; Wood, R E

2018-01-01

Background/Objectives: The MATADOR (Minimising Adaptive Thermogenesis And Deactivating Obesity Rebound) study examined whether intermittent energy restriction (ER) improved weight loss efficiency compared with continuous ER and, if so, whether intermittent ER attenuated compensatory responses associated with ER. Subjects/Methods: Fifty-one men with obesity were randomised to 16 weeks of either: (1) continuous (CON), or (2) intermittent (INT) ER completed as 8 × 2-week blocks of ER alternating with 7 × 2-week blocks of energy balance (30 weeks total). Forty-seven participants completed a 4-week baseline phase and commenced the intervention (CON: N=23, 39.4±6.8 years, 111.1±9.1 kg, 34.3±3.0 kg m−2; INT: N=24, 39.8±9.5 years, 110.2±13.8 kg, 34.1±4.0 kg m−2). During ER, energy intake was equivalent to 67% of weight maintenance requirements in both groups. Body weight, fat mass (FM), fat-free mass (FFM) and resting energy expenditure (REE) were measured throughout the study. Results: For the N=19 CON and N=17 INT who completed the intervention per protocol, weight loss was greater for INT (14.1±5.6 vs 9.1±2.9 kg; P<0.001). INT had greater FM loss (12.3±4.8 vs 8.0±4.2 kg; P<0.01), but FFM loss was similar (INT: 1.8±1.6 vs CON: 1.2±2.5 kg; P=0.4). Mean weight change during the 7 × 2-week INT energy balance blocks was minimal (0.0±0.3 kg). While reduction in absolute REE did not differ between groups (INT: -502±481 vs CON: −624±557 kJ d−1; P=0.5), after adjusting for changes in body composition, it was significantly lower in INT (INT: −360±502 vs CON: −749±498 kJ d−1; P<0.05). Conclusions: Greater weight and fat loss was achieved with intermittent ER. Interrupting ER with energy balance ‘rest periods’ may reduce compensatory metabolic responses and, in turn, improve weight loss efficiency. PMID:28925405

CD4 T cell subsets in the Mucosa are CD28+Ki-67−HLA-DR−CD69+ but show differential infection based on α4β7 receptor expression during acute SIV infection

PubMed Central

Kader, Muhamuda; Bixler, Sandra; Roederer, Mario; Veazey, Ronald; Mattapallil, Joseph J.

2009-01-01

Background CD4 T cell depletion in the mucosa has been well documented during acute HIV and SIV infections. The demonstration the HIV/SIV can use the α4β7 receptor for viral entry suggests that these viruses selectively target CD4 T cells in the mucosa that express high levels of α4β7 receptor. Methods Mucosal samples obtained from SIV infected rhesus macaques during the early phase of infection were used for immunophenotypic analysis. CD4 T cell subsets were sorted based on the expression of β7 and CD95 to quantify the level of SIV infection in different subsets of CD4 T cells. Changes in IL-17, IL-21, IL-23 and TGFβ mRNA expression was determined using Taqman PCR. Results CD4 T cells in the mucosa were found to harbor two major population of cells; ~25% of CD4 T cells expressed the α4+β7hi phenotype, whereas the rest of the 75% expressed an α4+β7int phenotype. Both the subsets were predominantly CD28+Ki-67− HLA-DR− but CD69+, and expressed detectable levels of CCR5 on their surface. Interestingly, however, α4+β7hiCD4 T cells were found to harbor more SIV than the α4+β7int subsets at day 10 pi. Early infection was associated with a dramatic increase in the expression of IL-17, and IL-17 promoting cytokines IL-21, IL-23, and TGFβ that stayed high even after the loss of mucosal CD4 T cells. Conclusions Our results suggest that the differential expression of the α4β7 receptor contributes to the differences in the extent of infection in CD4 T cell subsets in the mucosa. Early infection associated dysregulation of the IL-17 network in mucosal tissues involves other non-Th-17 cells that likely contributes to the pro-inflammatory environment in the mucosa during acute stages of SIV infection. PMID:19863675

Effects of genetically modified cotton stalks on antibiotic resistance genes, intI1, and intI2 during pig manure composting.

PubMed

Duan, Manli; Gu, Jie; Wang, Xiaojuan; Li, Yang; Zhang, Sheqi; Yin, Yanan; Zhang, Ranran

2018-01-01

Genetically modified (GM) cotton production generates a large yield of stalks and their disposal is difficult. In order to study the feasibility of using GM cotton stalks for composting and the changes that occur in antibiotic resistance genes (ARGs) during composting, we supplemented pig manure with GM or non-GM cotton stalks during composting and we compared their effects on the absolute abundances (AA) of intI1, intI2, and ARGs under the two treatments. The compost was mature after processing based on the germination index and C/N ratio. After composting, the AAs of ARGs, intI1, and intI2 were reduced by 41.7% and 45.0% in the non-GM and GM treatments, respectively. The ARG profiles were affected significantly by temperature and ammonia nitrogen. In addition, excluding tetC, GM cotton stalks had no significant effects on ARGs, intI1, and intI2 compared with the non-GM treatment (p < 0.05). Thus, similar to non-GM cotton stalks, GM cotton stalks can be used for aerobic composting with livestock manure, and the AAs of ARGs can be reduced. Furthermore, the results of this study provide a theoretical basis for the harmless utilization of GM cotton stalks. Copyright © 2017 Elsevier Inc. All rights reserved.

Maritime Analytics Prototype: Phase 3 Validation

DTIC Science & Technology

2014-01-01

maritim arehouse (GP ported on th sability Sca the training sks, errors m estionnaire, as assessed u the trial was t ” in the scien icant improv...which ed that MVA tools, and th ated the mo e, and becaus lot of prais essels. t - s, e s) n r e e e - e n s, e is P e st e e ii...rapport a environne en raison permet de une bonne navires d’ é ….... t documente n banc d’ess l’analyse de intérêt. Les c iel Widget A DDC) sur l ISTIP

Resistance-based interval exercise acutely improves endothelial function in type 2 diabetes.

PubMed

Francois, Monique E; Durrer, Cody; Pistawka, Kevin J; Halperin, Frank A; Little, Jonathan P

2016-11-01

Different modes of exercise, disease, and training status can modify endothelial shear stress and result in distinct effects on endothelial function. To date, no study has examined the influence of type 2 diabetes (T2D) and training status on the acute endothelial response to different modes of interval exercise (INT). We examined the effect of a single session of resistance- and cardio-based INT compared with a time-matched control on endothelial function in 12 age-matched T2D participants, 12 untrained, and 11 trained adults (aged 56 ± 7 yr). Flow-mediated dilation (%FMD) of the brachial artery was assessed at baseline and immediately, 1, and 2 h after an acute bout of cardio interval (C-INT), resistance interval (R-INT), and seated control (CTL); these interventions were randomized and separated by >2 days. C-INT involved seven 1-min cycling intervals at 85% of peak power with 1-min recovery between. R-INT involved the same pattern of seven 1-min intervals using leg resistance exercises. Endothelial function (%FMD) was improved after R-INT in all groups (Condition × Time interaction, P < 0.01), an effect that was most robust in T2D where %FMD was higher immediately (+4.0 ± 2.8%), 1 h (+2.5 ± 2.5%), and 2 h (+1.9 ± 1.9%) after R-INT compared with CTL (P < 0.01 for all). C-INT improved %FMD in T2D at 1-h postexercise (+1.6 ± 2.2%, P = 0.03) compared with CTL. In conclusion, R-INT acutely improves endothelial function throughout the 2-h postexercise period in T2D patients. The long-term impact of resistance exercise performed in an interval pattern is warranted. Copyright © 2016 the American Physiological Society.

Resistance-based interval exercise acutely improves endothelial function in type 2 diabetes

PubMed Central

Francois, Monique E.; Durrer, Cody; Pistawka, Kevin J.; Halperin, Frank A.

2016-01-01

Different modes of exercise, disease, and training status can modify endothelial shear stress and result in distinct effects on endothelial function. To date, no study has examined the influence of type 2 diabetes (T2D) and training status on the acute endothelial response to different modes of interval exercise (INT). We examined the effect of a single session of resistance- and cardio-based INT compared with a time-matched control on endothelial function in 12 age-matched T2D participants, 12 untrained, and 11 trained adults (aged 56 ± 7 yr). Flow-mediated dilation (%FMD) of the brachial artery was assessed at baseline and immediately, 1, and 2 h after an acute bout of cardio interval (C-INT), resistance interval (R-INT), and seated control (CTL); these interventions were randomized and separated by >2 days. C-INT involved seven 1-min cycling intervals at 85% of peak power with 1-min recovery between. R-INT involved the same pattern of seven 1-min intervals using leg resistance exercises. Endothelial function (%FMD) was improved after R-INT in all groups (Condition × Time interaction, P < 0.01), an effect that was most robust in T2D where %FMD was higher immediately (+4.0 ± 2.8%), 1 h (+2.5 ± 2.5%), and 2 h (+1.9 ± 1.9%) after R-INT compared with CTL (P < 0.01 for all). C-INT improved %FMD in T2D at 1-h postexercise (+1.6 ± 2.2%, P = 0.03) compared with CTL. In conclusion, R-INT acutely improves endothelial function throughout the 2-h postexercise period in T2D patients. The long-term impact of resistance exercise performed in an interval pattern is warranted. PMID:27638878

77 FR 29750 - Fifteenth Meeting: RTCA Special Committee 214, Joint With EUROCAE WG-78, Standards for Air...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-18

[email protected] , or Tel.: +31 43 366 1396. FOR FURTHER INFORMATION CONTACT: The RTCA Secretariat, 1150 18th....int no later than May 21, 2012 with the following security information: Last Name/ First name... cargo hangers-- first flight at between 06:00 and 06:15) SUPPLEMENTARY INFORMATION: Pursuant to section...

Spectrum Situational Awareness Capability: The Military Need and Potential Implementation Issues

DTIC Science & Technology

2006-10-01

Management Sensor Systems Frequency Management EW Systems Frequency Management Allied Battlespace Spectrum Management Restricted Frequency List Frequency...Management Restricted Frequency List Frequency Allocation Table Civil Frequency Use Data Inputs Negotiation and allocation process © Dstl 2006 26th...Management Restricted Frequency List Data Inputs Negotiation and allocation process Frequency Allocation Table SSA ES INT COP etc WWW Spectrum

Fixed interface charges between AlGaN barrier and gate stack composed of in situ grown SiN and Al{sub 2}O{sub 3} in AlGaN/GaN high electron mobility transistors with normally off capability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Capriotti, M., E-mail: mattia.capriotti@tuwien.ac.at; Alexewicz, A.; Fleury, C.

2014-03-17

Using a generalized extraction method, the fixed charge density N{sub int} at the interface between in situ deposited SiN and 5 nm thick AlGaN barrier is evaluated by measurements of threshold voltage V{sub th} of an AlGaN/GaN metal insulator semiconductor high electron mobility transistor as a function of SiN thickness. The thickness of the originally deposited 50 nm thick SiN layer is reduced by dry etching. The extracted N{sub int} is in the order of the AlGaN polarization charge density. The total removal of the in situ SiN cap leads to a complete depletion of the channel region resulting in V{sub th} = +1 V.more » Fabrication of a gate stack with Al{sub 2}O{sub 3} as a second cap layer, deposited on top of the in situ SiN, is not introducing additional fixed charges at the SiN/Al{sub 2}O{sub 3} interface.« less

System Synthesis for Polymorphous Computing Architectures

DTIC Science & Technology

2002-02-01

G H F Proc 5 : 4 : 3 11 1 Figure 3. Self-timed execution. D C B F G H E D B H EA CG F D C B F G H E D B H EA CG F AProc 1 Proc 2...first-iteration actors denoted by T. D B H E CG F D C B F G H E D B H EA CG F A 18 T T T T Proc 3 Proc 4 Proc 5 Proc 1 Proc 2 1 T⁄ T trmin30 ture-mirror...Phase1Algo( , ) = transientReduction( ) Output T G S′ S G T S′ S S′ Figure 11. Pseudocode to find

Fuels Combustion Research.

DTIC Science & Technology

1982-07-30

Institute, Paper 78-42 (1978). 3. Colket, M.B., Naegeli , D.W. and Glassman, I., "High Temperature Pyro- lysis of Acetaldehyde", Int’l J. of Chem...Kinetics 7. 233 (1975). 4. Aronowitz, D. and Naegeli , D.W., "High Temperature Pyrolysis of Di-methylether", Int’l J. Chem. Kinetics_ 471 (1977). • 5

A Review of PROC IRT in SAS

ERIC Educational Resources Information Center

Choi, Jinnie

2017-01-01

This article reviews PROC IRT, which was added to Statistical Analysis Software in 2014. We provide an introductory overview of a free version of SAS, describe what PROC IRT offers for item response theory (IRT) analysis and how one can use PROC IRT, and discuss how other SAS macros and procedures may compensate the IRT functionalities of PROC IRT.

Becoming angular momentum density flow through nonlinear mass transfer into a gravitating spheroidal body

NASA Astrophysics Data System (ADS)

Krot, A. M.

2009-04-01

A statistical theory for a cosmological body forming based on the spheroidal body model has been proposed in the works [1]-[4]. This work studies a slowly evolving process of gravitational condensation of a spheroidal body from an infinitely distributed gas-dust substance in space. The equation for an initial evolution of mass density function of a gas-dust cloud is considered here. It is found this equation coincides completely with the analogous equation for a slowly gravitational compressed spheroidal body [5]. A conductive flow in dissipative systems was investigated by I. Prigogine in his works (see, for example, [6], [7]). As it has been found in [2], [5], there exists a conductive antidiffusion flow in a slowly compressible gravitating spheroidal body. Applying the equation of continuity to this conductive flow density we obtain a linear antidiffusion equation [5]. However, if an intensity of conductive flow density increases sharply then the linear antidiffusion equation becomes a nonlinear one. Really, it was pointed to [6] analogous linear equations of diffusion or thermal conductivity transform in nonlinear equations respectively. In this case, the equation of continuity describes a nonlinear mass flow being a source of instabilities into a gravitating spheroidal body because the gravitational compression factor G is a function of not only time but a mass density. Using integral substitution we can reduce a nonlinear antidiffusion equation to the linear antidiffusion equation relative to a new function. If the factor G can be considered as a specific angular momentum then the new function is an angular momentum density. Thus, a nonlinear momentum density flow induces a flow of angular momentum density because streamlines of moving continuous substance come close into a gravitating spheroidal body. Really, the streamline approach leads to more tight interactions of "liquid particles" that implies a superposition of their specific angular momentums. This superposition forms an antidiffusion flow of an angular momentum density into a gravitating spheroidal body. References: [1] Krot, A.M. The statistical model of gravitational interaction of particles. Achievement in Modern Radioelectronics (spec.issue"Cosmic Radiophysics", Moscow), 1996, no.8, pp. 66-81 (in Russian). [2] Krot, A.M. Statistical description of gravitational field: a new approach. Proc. SPIE's 14th Annual Intern.Symp. "AeroSense", Orlando, Florida, USA, 2000, vol.4038, pp.1318-1329. [3] Krot, A.M. The statistical model of rotating and gravitating spheroidal body with the point of view of general relativity. Proc.35th COSPAR Scientific Assembly, Paris, France, 2004, Abstract A-00162. [4] Krot, A. The statistical approach to exploring formation of Solar system. Proc.EGU General Assembly, Vienna, Austria, 2006, Geophys.Res.Abstracts, vol.8, A-00216; SRef-ID: 1607-7962/gra/. [5] Krot, A.M. A statistical approach to investigate the formation of the solar system. Chaos, Solitons and Fractals, 2008, doi:10.1016/j.chaos.2008.06.014. [6] Glansdorff, P. and Prigogine, I. Thermodynamic Theory of Structure, Stability and Fluctuations. London, 1971. [7] Nicolis, G. and Prigogine, I. Self-organization in Nonequilibrium Systems:From Dissipative Structures to Order through Fluctuation. John Willey and Sons, New York etc., 1977.

Nurse management for hypertension. A systems approach.

PubMed

Rudd, Peter; Miller, Nancy Houston; Kaufman, Judy; Kraemer, Helena C; Bandura, Albert; Greenwald, George; Debusk, Robert F

2004-10-01

Standard office-based approaches to controlling hypertension show limited success. Such suboptimal hypertension control reflects in part the absence of both an infrastructure for patient education and frequent, regular blood pressure (BP) monitoring. We tested the efficacy of a physician-directed, nurse-managed, home-based system for hypertension management with standardized algorithms to modulate drug therapy, based on patients' reports of home BP. We randomized outpatients requiring drug therapy for hypertension according to the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC VI) criteria to receive usual medical care only (UC, n = 76) or usual care plus nurse care management intervention (INT, n = 74) over a 6-month period. Patients receiving INT achieved greater reductions in office BP values at 6 months than those receiving UC: 14.2 +/- 18.1 versus 5.7 +/- 18.7 mm Hg systolic (P < .01) and 6.5 +/- 10.0 versus 3.4 +/- 7.9 mm Hg diastolic, respectively (P < .05). At 6 months, we observed one or more changes in drug therapy in 97% of INT patients versus 43% of UC patients, and 70% of INT patients received two or more drugs versus 46% of UC. Average daily adherence to medication, measured by electronic drug event monitors, was superior among INT subjects (mean +/- SD, 80.5% +/- 23.0%) than among UC subjects (69.2 +/- 31.1%; t(113) = 2.199, P = .03). There were no significant adverse drug reactions in either group. Telephone-mediated nurse management can successfully address many of the systems-related and patient-related issues that limit pharmacotherapeutic effectiveness for hypertension.

Dimensionnement des actionneurs électriques alimentés à fréquence variable sous faible tension

NASA Astrophysics Data System (ADS)

Biedinger, J.-M.; Vilain, J.-P.

1999-09-01

In Part I we present a multidisciplinary analysis model for the prediction of functional connections between the design variables and the electromagnetical, electrical and thermal performances of a brushless permanent magnet motor. In this paper we have elaborated a design methodology for electrical motors supplied from a variable-frequency low-voltage source. The objective is to take into account the influence of the inverter's dynamics from the beginning of the design, for the same reasons as we do for electromechanical and thermal constraints. The procedure is based on a Sequential Quadratic Programming optimization method. Two techniques are used to take into account the influence of the inverter: the first one develops the performance analysis with the multidisciplinary model; the second one considers the inverter's current reference as a supplementary optimization variable for the control of the design. Optimization difficulties linked to the chopping of the converter are discuted in connection with a sensitivity analysis of the torque, with respect to the inverter's current reference; a method is proposed to enhance the performances of the algorithm. The method has been applied to the design of a permanent magnet brushless DC motor used in the propulsion system of an electrical scooter; evolution of the design with the complexity level of analysis model is evidenced. Dans une première partie nous avons développé un modèle d'analyse pluridisciplinaire qui établissait les dépendances fonctionnelles entre les variables de conception et les performances magnéto-électro-thermiques d'un moteur brushless à aimants permanents. Dans cet article nous décrivons une procédure de dimensionnement adaptée à la conception de la machine alimentée à fréquence variable sous faible tension. L'objectif est d'intégrer la dynamique du convertisseur électronique dès la phase initiale du dimensionnement, au même titre que les spécifications électromécaniques et thermiques. La procédure est gérée par une méthode d'optimisation déterministe de type Programmation Quadratique Séquentielle. Elle intègre l'influence du convertisseur au moyen de deux spécificités : la première consiste à évaluer les fonctions du problème d'optimisation sur la base du module d'analyse pluridisciplinaire ; la deuxième permet de contrôler l'évolution du dimensionnement au travers de variables d'optimisation dont la liste inclut les consignes de la commande en courant du convertisseur. Les difficultés d'optimisation liées au mode de fonctionnement discret du convertisseur sont discutées au regard du calcul de la sensibilité du couple électromagnétique envers la consigne de courant du convertisseur ; une méthode est proposée pour assurer la robustesse de la procédure en présence du convertisseur. L'application porte sur le dimensionnement d'un moteur à aimants permanents de type “brushless trapézoïdal" destiné à la traction d'un scooter électrique ; l'évolution de la structure optimale avec le degré de complexité du module d'analyse est mise en évidence.

delta 9-(16 alpha-/sup 125/I)iodo-19-nortestosterone: a gamma-emitting photoaffinity label for the progesterone receptor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lamb, D.J.; Bullock, D.W.; Hoyte, R.M.

1988-05-01

We have synthesized 16 alpha-iodo-4,9-estradien-17 beta-ol-3-one (delta 9-16 alpha-iodo-19-nortestosterone (delta 9-INT)) labeled with 125I (delta 9-(16 alpha-125I)INT) to provide a new gamma-emitting photoaffinity ligand for the progesterone receptor that has many advantages over the currently available (3H)R5020. We have characterized the interaction of delta 9-(16 alpha-125I)INT with the rabbit uterine progesterone receptor and have demonstrated the usefulness of this compound for studies of receptor structure. The binding of 2 nM (3H)progesterone to receptor in rabbit uterine cytosol was specifically competed for by 19-nortestosterone, 16 alpha-iodo-19-nortestosterone, and delta 9-INT. Scatchard analysis demonstrated that delta 9-(16 alpha-125I)INT and (3H)progesterone estimated the samemore » number of binding sites in rabbit uterine cytosol, with a Kd for delta 9-(16 alpha-125I)INT of about 2.7 nM. The binding of delta 9-(16 alpha-125I)INT was inhibited by both progesterone and R5020, whereas testosterone, estradiol, and 5 alpha-dihydrotestosterone were ineffective. In cytosol, delta 9-(16 alpha-125I)INT covalently labeled the same mol wt receptor forms as (3H)R5020. Although the efficiency of cross-linking was similar for (3H)R5020 (3%) and delta 9-(16 alpha-125I)INT (4%), the radioactivity was 10-fold greater due to the higher specific activity of delta 9-(16 alpha-125I)INT and the lack of sample quench. The use of delta 9-(16 alpha-125I)INT greatly increases the sensitivity and efficiency of the photoaffinity labeling technique; it will provide a valuable tool for further studies of the progesterone receptor, allowing the detection of receptor in dilute cytosol after gel electrophoresis under denaturing conditions.« less

Effect of odanacatib on bone turnover markers, bone density and geometry of the spine and hip of ovariectomized monkeys: a head-to-head comparison with alendronate.

PubMed

Williams, Donald S; McCracken, Paul J; Purcell, Mona; Pickarski, Maureen; Mathers, Parker D; Savitz, Alan T; Szumiloski, John; Jayakar, Richa Y; Somayajula, Sangeetha; Krause, Stephen; Brown, Keenan; Winkelmann, Christopher T; Scott, Boyd B; Cook, Lynn; Motzel, Sherri L; Hargreaves, Richard; Evelhoch, Jeffrey L; Cabal, Antonio; Dardzinski, Bernard J; Hangartner, Thomas N; Duong, Le T

2013-10-01

Odanacatib (ODN) is a selective and reversible Cathepsin K (CatK) inhibitor currently being developed as a once weekly treatment for osteoporosis. Here, effects of ODN compared to alendronate (ALN) on bone turnover, DXA-based areal bone mineral density (aBMD), QCT-based volumetric BMD (vBMD) and geometric parameters were studied in ovariectomized (OVX) rhesus monkeys. Treatment was initiated 10 days after ovariectomy and continued for 20 months. The study consisted of four groups: L-ODN (2 mg/kg, daily p.o.), H-ODN (8/4 mg/kg daily p.o.), ALN (15 μg/kg, twice weekly, s.c.), and VEH (vehicle, daily, p.o.). L-ODN and ALN doses were selected to approximate the clinical exposures of the ODN 50-mg and ALN 70-mg once-weekly, respectively. L-ODN and ALN effectively reduced bone resorption markers uNTx and sCTx compared to VEH. There was no additional efficacy with these markers achieved with H-ODN. Conversely, ODN displayed inversely dose-dependent reduction of bone formation markers, sP1NP and sBSAP, and L-ODN reduced formation to a lesser degree than ALN. At month 18 post-OVX, L-ODN showed robust increases in lumbar spine aBMD (11.4%, p<0.001), spine trabecular vBMD (13.7%, p<0.001), femoral neck (FN) integral (int) vBMD (9.0%, p<0.001) and sub-trochanteric proximal femur (SubTrPF) int vBMD, (6.4%, p<0.001) compared to baseline. L-ODN significantly increased FN cortical thickness (Ct.Th) and cortical bone mineral content (Ct.BMC) by 22.5% (p<0.001) and 21.8% (p<0.001), respectively, and SubTrPF Ct.Th and Ct.BMC by 10.9% (p<0.001) and 11.3% (p<0.001) respectively. Compared to ALN, L-ODN significantly increased FN Ct. BMC by 8.7% (p<0.05), and SubTrPF Ct.Th by 7.6% (p<0.05) and Ct.BMC by 6.2% (p<0.05). H-ODN showed no additional efficacy compared to L-ODN in OVX-monkeys in prevention mode. Taken together, the results from this study have demonstrated that administration of ODN at levels which approximate clinical exposure in OVX-monkeys had comparable efficacy to ALN in DXA-based aBMD and QCT-based vBMD. However, FN cortical mineral content clearly demonstrated superior efficacy of ODN versus ALN in this model of estrogen-deficient non-human primates. © 2013 Elsevier Inc. All rights reserved.

Steve Rummel | NREL

Science.gov Websites

Module Intercomparison," Proc. Solar Energies Technologies Review Meeting Nov. 7-10, 2005, NREL tech . Rummel, D.R. Myers, T.L. Stoffel, and D. Waddington, "A Comparison of Photovoltaic Calibration

Tsunami Focusing and Leading Amplitude

NASA Astrophysics Data System (ADS)

Kanoglu, U.

2016-12-01

Tsunamis transform substantially through spatial and temporal spreading from their source region. This substantial spreading might result unique maximum tsunami wave heights which might be attributed to the source configuration, directivity, the waveguide structures of mid-ocean ridges and continental shelves, focusing and defocusing through submarine seamounts, random focusing due to small changes in bathymetry, dispersion, and, most likely, combination of some of these effects. In terms of the maximum tsunami wave height, after Okal and Synolakis (2016 Geophys. J. Int. 204, 719-735), it is clear that dispersion would be one of the reasons to drive the leading wave amplitude in a tsunami wave train. Okal and Synolakis (2016), referring to this phenomenon as sequencing -later waves in the train becoming higher than the leading one, considered Hammack's (1972, Ph.D. Dissertation, Calif. Inst. Tech., 261 pp) formalism, in addition to LeMéhauté and Wang's (1995 Water waves generated by underwater explosion, World Scientific, 367 pp), to evaluate linear dispersive tsunami propagation from a circular plug uplifted on an ocean of constant depth. They identified transition distance, as the second wave being larger, performing parametric study for the radius of the plug and the depth of the ocean. Here, we extend Okal and Synolakis' (2016) analysis to an initial wave field with a finite crest length and, in addition, to a most common tsunami initial wave form of N-wave (Tadepalli and Synolakis, 1994 Proc. R. Soc. A: Math. Phys. Eng. Sci. 445, 99-112). First, we investigate the focusing feature in the leading-depression side, which enhance tsunami wave height as presented by Kanoglu et al. (2013 Proc. R. Soc. A: Math. Phys. Eng. Sci. 469, 20130015). We then discuss the results in terms of leading wave amplitude presenting a parametric study and identify a simple relation for the transition distance. The solution presented here could be used to better analyze dispersive characteristics of shallow water-wave numerical models and for benchmarking, in addition to the benchmark problems in Synolakis et al. (2008 Pure Appl. Geophys. 165(11-12), 2197-2228). This study received funding from project ASTARTE-Assessment Strategy and Risk Reduction for Tsunamis in Europe, a collaborative project Grant 603839, FP7-ENV2013 6.4-3.

Cost-effectiveness of the Mental Health and Development model for schizophrenia-spectrum and bipolar disorders in rural Kenya.

PubMed

de Menil, V; Knapp, M; McDaid, D; Raja, S; Kingori, J; Waruguru, M; Wood, S K; Mannarath, S; Lund, C

2015-10-01

The treatment gap for serious mental disorders across low-income countries is estimated to be 89%. The model for Mental Health and Development (MHD) offers community-based care for people with mental disorders in 11 low- and middle-income countries. In Kenya, using a pre-post design, 117 consecutively enrolled participants with schizophrenia-spectrum and bipolar disorders were followed-up at 10 and 20 months. Comparison outcomes were drawn from the literature. Costs were analysed from societal and health system perspectives. From the societal perspective, MHD cost Int$ 594 per person in the first year and Int$ 876 over 2 years. The cost per healthy day gained was Int$ 7.96 in the first year and Int$ 1.03 over 2 years - less than the agricultural minimum wage. The cost per disability-adjusted life year averted over 2 years was Int$ 13.1 and Int$ 727 from the societal and health system perspectives, respectively, on par with antiretrovirals for HIV. MHD achieved increasing returns over time. The model appears cost-effective and equitable, especially over 2 years. Its affordability relies on multi-sectoral participation nationally and internationally.

Addendum to strangeness production and color deconfinement

NASA Astrophysics Data System (ADS)

Castorina, P.; Plumari, S.; Satz, H.

Recent extensive data from the beam energy scan of the STAR collaboration at BNL-RHIC provide the basis for a detailed update for the universal behavior of the strangeness suppression factor γs as function of the initial entropy density as proposed in our recent paper (P. Castorina, S Plumari and H. Satz, Int. J. Mod. Phys. E 26 (2017) 1750081, arXiv:1709.02706 [nucl-th]).

The intranasal vaccination of pregnant dams with Intimin and EspB confers protection in neonatal mice from Escherichia coli (EHEC) O157:H7 infection.

PubMed

Rabinovitz, B C; Larzábal, M; Vilte, D A; Cataldi, A; Mercado, E C

2016-05-27

Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is responsible for intestinal disease and hemolytic uremic syndrome (HUS), a serious systemic complication which particularly affects children. In this study, we evaluated whether passive immunization protects from EHEC O157:H7 colonization and renal damage, by using a weaned BALB/c mouse model of infection. Recombinant proteins EspB and the carboxyl-terminal fragment of 280 amino acids of γ-intimin (γ-IntC280) were used in combination with a macrophage-activating lipopeptide-2 (MALP) adjuvant to immunize pregnant mice by the intranasal route. Neonatal mice were allowed to suckle vaccinated or sham-vaccinated dams until weaning when they were challenged by the oral route with a suspension of an E. coli O157:H7 Stx2+ strain. The excretion of the inoculated strain was followed for 72h. All vaccinated dams exhibited elevated serum IgG response against both γ-Int C280 and EspB. Passive immunization of newborn mice resulted in a significant increase in serum IgG titers against γ-Int C280 and a slight increase in EspB-specific antibodies. The neonates from vaccinated dams showed a significant reduction in EHEC O157:H7 colonization 48h post challenge. In addition, the level of plasma urea concentration, a marker of renal failure, was significantly higher in offsprings of sham-vaccinated mice. In conclusion, vaccination of pregnant dams with γ-Int C280 and EspB could reduce colonization and systemic toxicity of EHEC O157:H7 in their suckling offsprings. Copyright © 2016 Elsevier Ltd. All rights reserved.

Internet-delivered cognitive-behavioural therapy v. conventional guided self-help for bulimia nervosa: long-term evaluation of a randomised controlled trial.

PubMed

Wagner, Gudrun; Penelo, Eva; Wanner, Christian; Gwinner, Paulina; Trofaier, Marie-Louise; Imgart, Hartmut; Waldherr, Karin; Wöber-Bingöl, Ciçek; Karwautz, Andreas F K

2013-02-01

Cognitive-behavioural therapy (CBT)-based guided self-help is recommended as a first step in the treatment of bulimia nervosa. To evaluate in a randomised controlled trial (Clinicaltrials.gov registration number: NCT00461071) the long-term effectiveness of internet-based guided self-help (INT-GSH) compared with conventional guided bibliotherapy (BIB-GSH) in females with bulimia nervosa. A total of 155 participants were randomly assigned to INT-GSH or BIB-GSH for 7 months. Outcomes were assessed at baseline, month 4, month 7 and month 18. The greatest improvement was reported after 4 months with a continued reduction in eating disorder symptomatology reported at month 7 and 18. After 18 months, 14.6% (n = 7/48) of the participants in the INT-GSH group and 25% (n = 7/28) in the BIB-GSH group were abstinent from binge eating and compensatory measures, 43.8% (n = 21/48) and 39.2% (n = 11/28) respectively were in remission. No differences regarding outcome between the two groups were found. Internet-based guided self-help for bulimia nervosa was not superior compared with bibliotherapy, the gold standard of self-help. Improvements remain stable in the long term.

Axial displacement of external and internal implant-abutment connection evaluated by linear mixed model analysis.

PubMed

Seol, Hyon-Woo; Heo, Seong-Joo; Koak, Jai-Young; Kim, Seong-Kyun; Kim, Shin-Koo

2015-01-01

To analyze the axial displacement of external and internal implant-abutment connection after cyclic loading. Three groups of external abutments (Ext group), an internal tapered one-piece-type abutment (Int-1 group), and an internal tapered two-piece-type abutment (Int-2 group) were prepared. Cyclic loading was applied to implant-abutment assemblies at 150 N with a frequency of 3 Hz. The amount of axial displacement, the Periotest values (PTVs), and the removal torque values(RTVs) were measured. Both a repeated measures analysis of variance and pattern analysis based on the linear mixed model were used for statistical analysis. Scanning electron microscopy (SEM) was used to evaluate the surface of the implant-abutment connection. The mean axial displacements after 1,000,000 cycles were 0.6 μm in the Ext group, 3.7 μm in the Int-1 group, and 9.0 μm in the Int-2 group. Pattern analysis revealed a breakpoint at 171 cycles. The Ext group showed no declining pattern, and the Int-1 group showed no declining pattern after the breakpoint (171 cycles). However, the Int-2 group experienced continuous axial displacement. After cyclic loading, the PTV decreased in the Int-2 group, and the RTV decreased in all groups. SEM imaging revealed surface wear in all groups. Axial displacement and surface wear occurred in all groups. The PTVs remained stable, but the RTVs decreased after cyclic loading. Based on linear mixed model analysis, the Ext and Int-1 groups' axial displacements plateaued after little cyclic loading. The Int-2 group's rate of axial displacement slowed after 100,000 cycles.

Ceremony 25th birthday Cern

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2006-05-08

Célébration du 25ème anniversaire du Cern (jour par jour) avec discours de L.Van Hove et J.B.Adams, des interludes musicals offerts par Mme Mey et ses collègues (au debut 1.mouvement du quatuor avec piano no 3 de L.van Beethoven) Les directeurs généraux procéderont à la remise du souvenir aux membres de personnel ayant 25 années de service dans l'organisation. Un témoignage de reconnaissance est auss fait à l'interprète Mme Zwerner

Special Course on Skin Friction Drag Reduction Held in Rhode-St-Genese, Belgium on 2-6 March 1992 (Reduction de Trainee de Frottement)

DTIC Science & Technology

1992-03-01

bodies such as tor- or by using these in combination with other control pedoes , are ideal targets for applying transition delay methods will also be...sponsored Tani and his colleagues to Nikuradse’s experimental project in Cambridge University, high speed video data for sand grain rough pipes, (see [125...lent kinetic energy balance in a LEBU modified don (1990) - also video presented at EDRM4 Lau- turbulent boundary layer. Proc. 11th Turbulence sanne

Annual Review of Progress in Applied Computational Electromagnetics (5th), Held in Monterey, California on March 20-24 1989

DTIC Science & Technology

1989-01-01

circuit of the field equations of Maxwell ", Proc IRE, vol 32, Kay 1944, pp 360-367. 3. S. Akhtarzad P.B. Johns ,"Solution of Maxwell’s equations in three...ELFCTROMAGNETICS APPLIED TO INTEGRATED CIRCUIT MICROLITHOGRAPHY AND METROLOGY John C . Mould Jr. & Gregory L Wojc* Welinger Associates, 4410 El Camino Real, Los...1AICROLITHOGRAPHY AND METROLOGY John C . Mould Jr. & Gregory L Wo c * Weldlinger Associates, 4410 El Camino Real. Los Allos, Ca. 94022 1. Pholoreslat

ICO Topical Meeting on Atmospheric, Volume and Surface Scattering and Propagation Held in Florence, Italy on 27-30 August 1991

DTIC Science & Technology

1991-01-01

66,207 (1976). 3. M. Abitbol, " Wavefront Sensing in Adaptive Optics System," Ph.d Thesis submited to the senat of the Hebrew University OCt. 1990... thesis , University of London (In preparation). 14. Cope, M. et al (1989) Adv. in Exp. Med. & Biol., 247, 33-40 15. Kottler, F. (1980) Journal of the...Ph.D. Thesis . University of llelsinki, (1990) (9] K. Muinonen and K. Lumme. subm. to Proc. 126th I[AU (olloquiin, Kyoto. (1990) 221 1~ roughness=0.0

A Study of the Immunologic Response to Second Heterotypic Bluetongue Virus Infection in Mice

DTIC Science & Technology

1983-05-01

Bluetongue disease. Adv Vet Sci Comp Med 15: 1, 1971 24. Breckon RD, Luedke AJ, Walton TE: Bluetongue virus in bovine semen: Viral isolation. AM J Vet Res...Intervirology 3: 47, 1974 40. DuToit RM: Bluetongue --Recent advances in research. The role played by bovines in the transmission of bluetongue in sheep...AJ, Walton TE, Jones RE: Detection of bluetongue virus in bovine semen. Proc 20th World Vet Cong 3: 2039, 1975 154 99. Luedke AJ, Jochim MM, Jones RH

VizieR Online Data Catalog: GALAH semi-automated classification scheme (Traven+, 2017)

NASA Astrophysics Data System (ADS)

Traven, G.; Matijevic, G.; Zwitter, T.; Zerjal, M.; Kos, J.; Asplund, M.; Bland-Hawthorn, J.; Casey, A. R.; de Silva, G.; Freeman, K.; Lin, J.; Martell, S. L.; Schlesinger, K. J.; Sharma, S.; Simpson, J. D.; Zucker, D. B.; Anguiano, B.; da Costa, G.; Duong, L.; Horner, J.; Hyde, E. A.; Kafle, P. R.; Munari, U.; Nataf, D.; Navin, C. A.; Reid, W.; Ting, Y.-S.

2017-04-01

The GALactic Archaeology with HERMES (GALAH) survey was the main driver for the construction of Hermes (High Efficiency and Resolution Multi-Element Spectrograph), a fiber-fed multi-object spectrograph on the 3.9m Anglo-Australian Telescope. Its spectral resolving power (R) is about 28000, and there is also an R=45000 mode using a slit mask. Hermes has four simultaneous non-contiguous spectral arms centered at 4800, 5761, 6610, and 7740Å, covering about 1000Å in total, including Hα and Hβ lines. About 300000 spectra have been taken to date, including various calibration exposures. However, we concentrate on ~210000 spectra recorded before 2016 January 30. We devise a custom classification procedure which is based on two independently developed methods, the novel dimensionality reduction technique t-SNE (t-distributed stochastic neighbor embedding; van der Maaten & Hinton 2008, Journal of Machine Learning Research 9, 2579) and the renowned clustering algorithm DBSCAN (Ester+ 1996, Proc. 2nd Int. Conf. on KDD, 226 ed. E. Simoudis, J. Han, and U. Fayyad). (4 data files).

Electron Impact K-shell Ionization of Atomic Targets

NASA Astrophysics Data System (ADS)

Saha, Bidhan; Basak, Arun K.; Alfaz Uddin, M.; Patoary, A. A. R.

2008-05-01

In spite of considerable progress -both theoretically and experimentally- recently in evaluating accurate K-shell ionization cross sections that play a decisive role for quantitative analyses using (i) electron probe microanalysis, (ii) Auger electron spectroscopy and (iii) electron energy loss spectra, attempts are still continuing to search for a model that can easily generate reliable cross sections for a wide range of energies and for various targets needed for plasma modeling code We report few modifications of the widely used binary encounter approximation (BEA) [1,2] and have tested by evaluating the electron impact K-shell ionization of few neutral targets at various projectile energies. Details will be presented at the meeting. [1] M. Gryziniski, Phys. Rev. A 138, 336 (1965); [2] L. Vriens, Proc. Phys. Soc. (London) 89, 13, (1966). [3M. A. Uddin , A. K. F. Haque, M. M. Billah, A. K. Basak, K, R, Karim and B. C. Saha, ,Phys. Rev. A 71,032715 (2005); [4] M. A. Uddin, A. K. Basak, and B. C. Saha, Int. J. Quan. Chem 100, 184 (2004).

Concordance et apports de l'hystérosalpingographie et de la cœlioscopie dans l'exploration tubaire et pelvienne en cas d'infertilité

PubMed Central

Kehila, Mehdi; Ben Hmid, Rim; Ben Khedher, Sonia; Mahjoub, Sami; Channoufi, Mohamed Bedis

2014-01-01

Introduction La coelioscopie et l'hystérosalpingographie sont les deux procédures usuellement admises pour l'exploration tubaire et pelvienne en cas d'infertilité. Les objectifs de ce travail etaient de comparer les données de l'Hystérosalpingographie à celles de la coelioscopie chez des patientes explorées pour infertilité et voir l'apport de l'une par rapport à l'autre. Méthodes Etude prospective menée au service C du centre de maternité et de néonatologie de Tunis, s’étendant sur 15 mois, colligeant 120 patientes suivies pour infertilité ayant bénéficié d'une HSG suivie d'une coelioscopie. Résultats L’âge moyen de nos patientes était de 35,3 ans. L'infertilité était primaire dans 56,7% des cas et secondaire dans 43,7% des cas. Sa durée moyenne était de 48,9 mois. Le test statistique de concordance Kappa entre les 2 examens était de 0.42 pour les obstructions tubaires en général, de 0.48 pour les obstructions tubaires proximales et de 0.53 pour les obstructions tubaires distales indiquant une concordance modérée dans tous les cas. La coelioscopie a permis d'objectiver en plus une endométriose pelvienne dans 7% des cas, des adhérences pelviennes dans 33% des cas et des trompes perméables mais d'aspect pathologique dans 20% des cas. Conclusion Il existe un intérêt d′associer, chaque fois que c′est possible, l'HSG et la coelioscopie dans l'exploration du pelvis féminin dans le cadre de l'infertilité. Aucun de ces deux examens n'est parfait. Leurs résultats sont complémentaires. PMID:25374631

Dynamic programming re-ranking for PPI interactor and pair extraction in full-text articles

PubMed Central

2011-01-01

Background Experimentally verified protein-protein interactions (PPIs) cannot be easily retrieved by researchers unless they are stored in PPI databases. The curation of such databases can be facilitated by employing text-mining systems to identify genes which play the interactor role in PPIs and to map these genes to unique database identifiers (interactor normalization task or INT) and then to return a list of interaction pairs for each article (interaction pair task or IPT). These two tasks are evaluated in terms of the area under curve of the interpolated precision/recall (AUC iP/R) score because the order of identifiers in the output list is important for ease of curation. Results Our INT system developed for the BioCreAtIvE II.5 INT challenge achieved a promising AUC iP/R of 43.5% by using a support vector machine (SVM)-based ranking procedure. Using our new re-ranking algorithm, we have been able to improve system performance (AUC iP/R) by 1.84%. Our experimental results also show that with the re-ranked INT results, our unsupervised IPT system can achieve a competitive AUC iP/R of 23.86%, which outperforms the best BC II.5 INT system by 1.64%. Compared to using only SVM ranked INT results, using re-ranked INT results boosts AUC iP/R by 7.84%. Statistical significance t-test results show that our INT/IPT system with re-ranking outperforms that without re-ranking by a statistically significant difference. Conclusions In this paper, we present a new re-ranking algorithm that considers co-occurrence among identifiers in an article to improve INT and IPT ranking results. Combining the re-ranked INT results with an unsupervised approach to find associations among interactors, the proposed method can boost the IPT performance. We also implement score computation using dynamic programming, which is faster and more efficient than traditional approaches. PMID:21342534

Dynamic programming re-ranking for PPI interactor and pair extraction in full-text articles.

PubMed

Tsai, Richard Tzong-Han; Lai, Po-Ting

2011-02-23

Experimentally verified protein-protein interactions (PPIs) cannot be easily retrieved by researchers unless they are stored in PPI databases. The curation of such databases can be facilitated by employing text-mining systems to identify genes which play the interactor role in PPIs and to map these genes to unique database identifiers (interactor normalization task or INT) and then to return a list of interaction pairs for each article (interaction pair task or IPT). These two tasks are evaluated in terms of the area under curve of the interpolated precision/recall (AUC iP/R) score because the order of identifiers in the output list is important for ease of curation. Our INT system developed for the BioCreAtIvE II.5 INT challenge achieved a promising AUC iP/R of 43.5% by using a support vector machine (SVM)-based ranking procedure. Using our new re-ranking algorithm, we have been able to improve system performance (AUC iP/R) by 1.84%. Our experimental results also show that with the re-ranked INT results, our unsupervised IPT system can achieve a competitive AUC iP/R of 23.86%, which outperforms the best BC II.5 INT system by 1.64%. Compared to using only SVM ranked INT results, using re-ranked INT results boosts AUC iP/R by 7.84%. Statistical significance t-test results show that our INT/IPT system with re-ranking outperforms that without re-ranking by a statistically significant difference. In this paper, we present a new re-ranking algorithm that considers co-occurrence among identifiers in an article to improve INT and IPT ranking results. Combining the re-ranked INT results with an unsupervised approach to find associations among interactors, the proposed method can boost the IPT performance. We also implement score computation using dynamic programming, which is faster and more efficient than traditional approaches.

Acupuncture-Based Biophysical Frontiers of Complementary Medicine

DTIC Science & Technology

2001-10-28

cf. Fig. 1, an evolutionary older type of intercell communications , transporting ionic electrical signals between excitable cells, whose conductivity...traditional psychology: Biophysical bases of psychosomatic disorders and transpersonal stress reprogramming", in Basic and Clinical Aspects of the Theory...biophysical basis of transpersonal transcendental phenomena", Int. J. Appl. Sci. & Computat, vol. 7, pp. 174-187, 2000 [also presented at Int. Conf

Utilization Management of Orthopedic Services by Fitzsimons Army Medical Center and Evans Army Community Hospital

DTIC Science & Technology

1993-08-01

LOS Mean LOS: Total LOS: positions g FAMC-HCFA FAMC-HCFA 214 Back & Neck Proc with CC 5 4.02 51.6 42.6 213 2_11 Wound Debrid & Skin Graft ex Hand, for...Administration (HCFA) DRG Dis- CMI FAMC LO5 Mean LOS: Total LOS: posit’i Mean FAMC-HCFA FAMC-HCFA 263 Skin Graft &/ox Debrid for Skin Ulcer or Cellulitis w CC...32.0 21.4 43 468 Extensive O.R. Proc Un- Related to Principal DX 16 3.42 7.6 -5.5 -89 217 Wound Debrid & Skin Graft ex Hand, for Muscskelet & Conn

Accelerated collagen turnover in women with angina pectoris without obstructive coronary artery disease: An iPOWER substudy.

PubMed

Nielsen, Signe H; Mygind, Naja D; Michelsen, Marie M; Bechsgaard, Daria F; Suhrs, Hannah E; Genovese, Federica; Nielsen, Henning B; Brix, Susanne; Karsdal, Morten; Prescott, Eva; Kastrup, Jens

2018-05-01

Aim Collagens are major cardiac extracellular matrix components, known to be actively remodelled and accumulated during diffuse myocardial fibrosis. We evaluated whether accelerated collagen turnover described by neo-epitope biomarkers reflecting collagen formation and degradation separates patients with diffuse myocardial fibrosis from asymptomatic controls. Methods and results Seventy-one women with angina pectoris without significant coronary artery disease assessed by invasive coronary angiogram were included. Competitive enzyme-linked immunosorbent assays (ELISAs) measuring circulating protein fragments in serum assessed the formation and degradation of collagen type III (Pro-C3, C3M and C3C), IV (P4NP7S and C4M), V (Pro-C5 and C5M) and VI (Pro-C6 and C6M), and degradation of collagen type I (C1M). Serum samples from 32 age-matched asymptomatic women were included as controls. Symptomatic women presented significantly elevated levels of Pro-C6, C3C, C3M, C4M and C8-C ( p < 0.0001-0.0058) and significantly decreased levels of Pro-C3, C5M and C6M ( p < 0.0001-0.041), reflecting accelerated collagen turnover and an imbalanced collagen formation and degradation compared to controls. Cardiac magnetic resonance T1 mapping was performed to determine extracellular volume fraction and thus diffuse myocardial fibrosis. A significant association was identified between C5M and extracellular volume fraction by cardiac magnetic resonance ( p = 0.01). Conclusion Women with angina pectoris, but without significant obstructive coronary artery disease, showed an imbalanced collagen turnover compared to asymptomatic controls. The examined biomarkers are tools to monitor active collagen remodelling in patients with angina pectoris, in risk of developing myocardial fibrosis.

Intérêt de l’algorithme rocuronium - sugammadex dans la laryngoscopie directe en suspension

PubMed Central

El jaouhari, Sidi Driss; Meziane, Mohamed; Ahtil, Redouane; Bensghir, Mustapha; Haimeur, Charki

2017-01-01

La laryngoscopie directe en suspension est un geste chirurgical diagnostique et/ou thérapeutique des lésions endo-laryngées. Sa gestion anesthésique est compliquée. Différentes techniques anesthésiques peuvent être proposées. Malgré les contraintes, les curares gardent tout leur intérêt. L’association rocuronium et sugammadex est envisageable, elle permet une inversion rapide du bloc neuromusculaire profond et par conséquent une réduction de la morbidité postopératoire. Nous rapportons un cas d’une laryngoscopie directe en suspension réalisée sous anesthésie générale dont l’utilisation de l’association rocuronium-sugammadex a permis une facilité du geste chirurgicale, une sécurité pour le patient et un confort pour l’anesthésiste. PMID:28690746

Effect of conventional and intensified milk replacer feeding programs on performance, vaccination response, and neutrophil mRNA levels of Holstein calves.

PubMed

Hengst, B A; Nemec, L M; Rastani, R R; Gressley, T F

2012-09-01

This study compared conventional and intensified milk replacer feeding regimens on growth, intake, respiratory and fecal scores, vaccination response, and neutrophil mRNA levels. Holstein calves were randomly assigned to a 10-wk study on d 2 of life. Treatments were conventional (CON; n=8) and intensified (INT; n=7) milk replacer feeding programs. Conventional calves were fed a 20.8% crude protein and 21.0% fat milk replacer at 1.25% of birth body weight (BW) from wk 1 to 6 of life and 0.625% of birth BW during wk 7. A 29.3% crude protein and 16.2% fat milk replacer was fed to INT calves at 1.5% of birth BW during wk 1, 2% of current BW from wk 2 to 6, and 1% of current BW during wk 7. All calves were given milk replacer twice daily during wk 1 to 6, once daily during wk 7, and were weaned completely during wk 8. Calf starter intake was measured daily through wk 8. Body weight and withers height were measured weekly. Fecal and respiratory scores were recorded twice daily at feeding. Calves were vaccinated against ovalbumin at the end of wk 1, 3, and 5. Blood samples were collected at the end of wk 1, 3, 5, and 8 for analysis of serum anti-ovalbumin IgG concentration and for isolation of neutrophils. Quantitative PCR was used to measure neutrophil mRNA levels of 7 functionality genes. Treatment did not affect total DMI or anti-ovalbumin IgG response. Intensified milk replacer feeding increased average daily gain, protein intake, fat intake, and feed efficiency compared with the CON feeding program. Compared with CON calves, INT calves had greater fecal scores, indicating looser feces and greater respiratory scores, indicating more respiratory problems. Calves assigned to the INT treatment had increased neutrophil mRNA levels of L-selectin, and at wk 8, neutrophil cytosolic factor 1 was increased and toll-like receptor 4 tended to be increased compared with CON calves. This suggests greater activation of neutrophils in INT calves postweaning, but differences were relatively small and levels of the other 4 genes were unaffected. An INT milk replacer feeding program increased growth, fecal scores, and respiratory scores preweaning, increased mRNA levels of 2 neutrophil genes postweaning, and did not affect vaccination response. Copyright © 2012 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Homozygous Expression of Mutant ELOVL4 Leads to Seizures and Death in a Novel Animal Model of Very Long-Chain Fatty Acid Deficiency.

PubMed

Hopiavuori, Blake R; Deák, Ferenc; Wilkerson, Joseph L; Brush, Richard S; Rocha-Hopiavuori, Nicole A; Hopiavuori, Austin R; Ozan, Kathryn G; Sullivan, Michael T; Wren, Jonathan D; Georgescu, Constantin; Szweda, Luke; Awasthi, Vibhudutta; Towner, Rheal; Sherry, David M; Anderson, Robert E; Agbaga, Martin-Paul

2018-02-01

Lipids are essential components of the nervous system. However, the functions of very long-chain fatty acids (VLC-FA; ≥ 28 carbons) in the brain are unknown. The enzyme ELOngation of Very Long-chain fatty acids-4 (ELOVL4) catalyzes the rate-limiting step in the biosynthesis of VLC-FA (Agbaga et al., Proc Natl Acad Sci USA 105(35): 12843-12848, 2008; Logan et al., J Lipid Res 55(4): 698-708, 2014), which we identified in the brain as saturated fatty acids (VLC-SFA). Homozygous mutations in ELOVL4 cause severe neuropathology in humans (Ozaki et al., JAMA Neurol 72(7): 797-805, 2015; Mir et al., BMC Med Genet 15: 25, 2014; Cadieux-Dion et al., JAMA Neurol 71(4): 470-475, 2014; Bourassa et al., JAMA Neurol 72(8): 942-943, 2015; Aldahmesh et al., Am J Hum Genet 89(6): 745-750, 2011) and are post-natal lethal in mice (Cameron et al., Int J Biol Sci 3(2): 111-119, 2007; Li et al., Int J Biol Sci 3(2): 120-128, 2007; McMahon et al., Molecular Vision 13: 258-272, 2007; Vasireddy et al., Hum Mol Genet 16(5): 471-482, 2007) from dehydration due to loss of VLC-SFA that comprise the skin permeability barrier. Double transgenic mice with homozygous knock-in of the Stargardt-like macular dystrophy (STDG3; 797-801_AACTT) mutation of Elovl4 with skin-specific rescue of wild-type Elovl4 expression (S + Elovl4 mut/mut mice) develop seizures by P19 and die by P21. Electrophysiological analyses of hippocampal slices showed aberrant epileptogenic activity in S + Elovl4 mut/mut mice. FM1-43 dye release studies showed that synapses made by cultured hippocampal neurons from S + Elovl4 mut/mut mice exhibited accelerated synaptic release kinetics. Supplementation of VLC-SFA to cultured hippocampal neurons from mutant mice rescued defective synaptic release to wild-type rates. Together, these studies establish a critical, novel role for ELOVL4 and its VLC-SFA products in regulating synaptic release kinetics and epileptogenesis. Future studies aimed at understanding the molecular mechanisms by which VLC-SFA regulate synaptic function may provide new targets for improved seizure therapies.

VizieR Online Data Catalog: Red supergiant population in Perseus arm (Dorda+, 2018)

NASA Astrophysics Data System (ADS)

Dorda, R.; Negueruela, I.; Gonzalez-Fernandez, C.

2018-03-01

The targets were observed during two different campaigns. The first one was done in 2011, on the nights of October 16-18. The second campaign was carried out in 2012, from September 3rd to 7th. We used the Intermediate Dispersion Spectrograph, mounted on the 2.5 m Isaac Newton Telescope (INT) in La Palma (Spain). In total, we observed 637 unique targets, 102 in 2011 and 535 in 2012, without any overlap between epochs. As discussed above, 43 of them are CSGs with well-determined SpTs (all but one observed in the 2012 run) that were included in the calibration sample of Paper III (see appendix B in that work). These objects are not considered part of the Perseus sample studied here. This leaves 594 targets in our sample, which are detailed in perseus.dat file. (1 data file).

187Re - 232Th - 238U nuclear geochronometry: constraining magmatism in East-Antarctica and the break-up of Gondwana

NASA Astrophysics Data System (ADS)

Roller, Goetz

2017-04-01

187Re - 232Th - 238U nuclear geochronometry is a new dating method for astronomy, earth and planetary sciences [1-4]. Nucleogeochronometric Rhenium-Osmium two-point-isochron (TPI) ages are calculated using a nuclear geochronometer as one data point in a two-point-isochron diagram [5-7]. The IVREA chronometer, for example, is one of five terrestrial nuclear geochronometers identified so far [8]. Here, it is used to constrain the magmatism of the Ferrar flood basalt province, which has been related to continental rifting and the break-up of Gondwana in the Jurassic.TPI ages for seven (basaltic) andesite whole rock samples from the Prince Albert Mountains (Victoria Land, Antarctica) are calculated. An isochron age of 172 ± 5 Ma (187Os/188Osi = 0.194 ± 0.023) has previously been published for these rocks [9]. Initial TPI 187Os/188Osi ratios show only minor scatter between 187Os/188Osi = 0.2149 ± 0.0064 and 187Os/188Osi = 0.22231 ± 0.00080, in agreement with the enigmatic, suprachondritic 187Os/188Osi = 0.194 ± 0.023 from the isochron [9]. TPI ages for the Mount Joyce samples range from 125.4 ± 9.9 Ma to 139 ± 17 Ma and thus constrain the youngest magmatic event(s) in the Transantarctic Mountains. For the Thumb Point basalt, a TPI age of 219 ± 81 Ma is calculated. Despite of its large uncertainty, the age itself is in agreement with the Triassic 224 Ma and 240 Ma events reported from North Patagonia [10]. The TPI age of 186.1 ± 8.1 Ma from the Ricker Hill basalt can be clearly distinguished from the Mount Murray TPI age of 158 ± 14 Ma, while at Brimstone Peak two TPI age groups of 155 ± 14 Ma and 175.3 ± 3.1 Ma are observed. From this it may be concluded that the seven TPI ages indicate episodic magmatic activity in East-Antarctica between 125 Ma and 219 Ma, leading to the break-up of Gondwana. This picture is consistent with the geochronology of the Antarctic Peninsula, Patagonia, the Karoo and the Ferrar mafic rocks [10]. Thus, besides constraining planetary crust formation in general, nuclear geochronometry may also become an additional powerful tool in constraining not only magmatic activity in Antarctica but also the assembly and break-up of Pangaea and subsequently Gondwana from the Carboniferous on, as revealed by means of nuclear geochronometry for the ultramafic dykes within the Balmuccia peridotite (Ivrea Zone, NW Italy). [1] Roller (2015), Goldschmidt Conf. Abstr. 25, 2672. [2] Roller (2016), Goldschmidt Conf. Abstr. 26, 2642. [3] Roller (2015), Geophys Res. Abstr. 17, 2399. [4] Roller (2016), Geophys Res. Abstr. 18, 33. [5] Roller (2016), JPS Conf. Proc., Nuclei in the Cosmos (NIC XIV), Niigata, Japan, subm. (NICXIV-001); NICXIV Abstr. #1570244284. [6] Roller (2016), JPS Conf. Proc., Nuclei in the Cosmos (NIC XIV), Niigata, Japan, subm. (NICXIV-002); NICXIV Abstr. #1570244285). [7] Roller (2016), JPS Conf. Proc., Nuclei in the Cosmos (NIC XIV), Niigata, Japan, subm. (NICXIV-003); NICXIV Abstr. #1570244281. [8] Roller (2015), Geophys Res. Abstr. 17, 17. [9] Molzahn et al. (1996), Earth Planet. Sci. Lett. 144, 529 - 546. [10] Pankhurst et al. (2000), J. Petrol. 41, 605 - 625.

Targeted Nanoparticles for Kidney Cancer Therapy

DTIC Science & Technology

2012-10-01

24 hrs. Clonogenic survival was assessed 7-10 days after CNT incubation after plating 200-300 cells/well (Figure 7). Similar trends were seen using... ferritin on angiogenesis. Proc Natl Acad Sci U S A. 2009;106(2):570-5. PMCID: 2626744. 4. Burke A, Ding X, Singh R, Kraft RA, Levi-Polyachenko N, Rylander

3 CFR 8649 - Proclamation 8649 of April 7, 2011. National Volunteer Week, 2011

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7, 2011 Proc. 8649 National Volunteer Week, 2011By the President of the United States of America A Proclamation America's story has been marked by the service of volunteers. Generations of selfless individuals... caring for older Americans to supporting our veterans and military families and rebuilding after...

75 FR 69741 - Proposed Collection; Comment Request for Rev. Proc. 2007-99 (RP-127367-07), 9100 Relief Under...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-15

.... Proc. 2007-99 (RP- 127367-07), 9100 Relief Under Sections 897 and 1445 AGENCY: Internal Revenue Service...)). Currently, the IRS is soliciting comments concerning Rev. Proc. 2007-99 (RP-127367-07), 9100 Relief Under...: Rev. Proc. 2007-99 (RP-127367-07), 9100 Relief Under Sections 897 and 1445. OMB Number: 1545-2098...

Molecular dynamics simulations of proton-ordered water confined in low-diameter carbon nanotubes.

PubMed

Li, Shujuan; Schmidt, Burkhard

2015-03-21

The present work deals with molecular dynamics simulations of water confined in single-walled carbon nanotubes (CNTs), with emphasis on the proton-ordering of water and its polarization. First, the water occupancy of open-ended armchair and zigzag CNTs immersed in water under ambient NPT conditions is calculated for various water models, and for varying Lennard-Jones parameters of the water-carbon interaction. As a function of the CNT diameter, the water density displays several oscillations before converging to the bulk value. Based on these results, the water structures encapsulated in 10 nm long armchair CNTs (n,n) with 5 ≤ n ≤ 10, are investigated under NVT conditions. Inside the smallest nanotubes (n = 5, 6) highly ferroelectric (FE), quasi-one-dimensional water chains are found while inside the other CNTs water molecules assemble into single-walled ice nanotubes (INTs). There are several, near-degenerate minimum energy INT structures: single helical structures were found for 7 ≤ n ≤ 10, in all cases in FE arrangement. In addition, a double helical INT structure was found for n = 8 with an even higher polarization. Prism-like structures were found only for 8 ≤ n ≤ 10 with various FE, ferrielectric (FI), and antiferroelectric (AF, n = 9, 10) proton ordering. The coexistence of the nearly iso-energetic FE, FI, and AF INT structures separated by high barriers renders the molecular dynamics highly metastable, typically with nanosecond timescales at room temperature. Hence, the replica exchange simulation method is used to obtain populations of different INT states at finite temperatures. Many of the FE INT structures confined in low-diameter CNTs are still prevalent at room temperature. Both helix-helix and helix-prism structural transitions are detected which can be either continuous (around 470 K for n = 8) or discontinuous (at 218 K for n = 9). Also melting-like transitions are found in which the INT structures are disrupted leading to a loss of FE or FI ordering of the water orientations. Also these transitions can be either smooth (for n = 7, 8) or abrupt, first-order transitions, at T = 362 K for n = 9 and at T = 285 K for n = 10.

37 CFR 7.7 - Payments of fees to International Bureau.

Code of Federal Regulations, 2012 CFR

2012-07-01

... MADRID AGREEMENT CONCERNING THE INTERNATIONAL REGISTRATION OF MARKS General Information § 7.7 Payments of...: http://www.wipo.int/madrid/en/. [68 FR 55769, Sept. 26, 2003, as amended at 69 FR 57185, Sept. 24, 2004] ...

37 CFR 7.7 - Payments of fees to International Bureau.

Code of Federal Regulations, 2014 CFR

2014-07-01

... MADRID AGREEMENT CONCERNING THE INTERNATIONAL REGISTRATION OF MARKS General Information § 7.7 Payments of...: http://www.wipo.int/madrid/en/. [68 FR 55769, Sept. 26, 2003, as amended at 69 FR 57185, Sept. 24, 2004] ...

37 CFR 7.7 - Payments of fees to International Bureau.

Code of Federal Regulations, 2011 CFR

2011-07-01

... MADRID AGREEMENT CONCERNING THE INTERNATIONAL REGISTRATION OF MARKS General Information § 7.7 Payments of...: http://www.wipo.int/madrid/en/. [68 FR 55769, Sept. 26, 2003, as amended at 69 FR 57185, Sept. 24, 2004] ...

37 CFR 7.7 - Payments of fees to International Bureau.

Code of Federal Regulations, 2010 CFR

2010-07-01

... MADRID AGREEMENT CONCERNING THE INTERNATIONAL REGISTRATION OF MARKS General Information § 7.7 Payments of...: http://www.wipo.int/madrid/en/. [68 FR 55769, Sept. 26, 2003, as amended at 69 FR 57185, Sept. 24, 2004] ...

37 CFR 7.7 - Payments of fees to International Bureau.

Code of Federal Regulations, 2013 CFR

2013-07-01

... MADRID AGREEMENT CONCERNING THE INTERNATIONAL REGISTRATION OF MARKS General Information § 7.7 Payments of...: http://www.wipo.int/madrid/en/. [68 FR 55769, Sept. 26, 2003, as amended at 69 FR 57185, Sept. 24, 2004] ...

METHODOLOGICAL ISSUES IN THE USE OF GENERALIZED ADDITIVE MODELS FOR THE ANALYSIS OF PARTICULATE MATTER; CONFERENCE PROCEEDINGS FOR 9TH INT'L. INHALATION SYMPOSIUM ON EFFECTS OF AIR CONTAMINANTS ON THE RESPIRATORY TRACT - INTERPRETATIONS FROM MOLECULES TO META ANALYSIS

EPA Science Inventory

Open cohort ("time-series") studies of the adverse health effects of short-term exposures to ambient particulate matter and gaseous co-pollutants have been essential in the standard setting process. Last year, a number of serious issues were raised concerning the fitting of Gener...

Surface Composition Influence on Internal Gas Flow at Large Knudsen Numbers

DTIC Science & Technology

2000-07-09

situated in an ultra high vacuum system . The system is supplied with means of gas phase, surface CP585, Rarefied Gas Dynamics: 22nd International...control and gas flow measuring system . The experimental procedure consists in a few stages. The first stage includes surface preparation process at...solid body system , Proceedings 20-th Int. Symp. Rarefied Gas Dynamics, Peking University Press, Beijing, China, 1997, pp. 387-391. 3. Lord, R.G

Performance Analysis of Polymorphous Computing Architectures

DTIC Science & Technology

2001-01-01

G H F Proc 5 : 4 : 3 11 1 Figure 3. Self-timed execution. D C B F G H E D B H EA CG...F D C B F G H E D B H EA CG F AProc 1 Proc 2 Proc 3 Proc 4 Proc 5 185 cution pattern when the application graph in Figure 2 is executed in a self...transform, a quadra- E Figure 10. Self-timed execution with first-iteration actors denoted by T. D B H E CG F D C B F G H E D B H EA CG F A 18 T T T

Environmental Assessment of Beneficiary Demographics, Needs and Demands, and Incidence of Disease for Wilford Hall USAF Medical Center Service Area

DTIC Science & Technology

1991-07-26

DI V CO 41 1337 TRAISUR PROSTATECT ( 33 1262 BREAST BIOP ION-MALI 41 169 MOUTH PROCS (70 34 91 PNEUMDNIA/ PLEURISY 0 38 1336 TRAISUR PROSTAT >69- 32...BACK PROBLEM 12 383 0TH ANTEPAR DX V CO 6 91 PNEUE)NIA/ PLEURISY 0 15 1112 OTHER VASCULAR PEOCS 9 1198 CHOLECYSTECTOMY (70 12 372 VAG DELIT V COWL DX 6...PECTORIS 360,008 89 SIMPLE PNEUMONIA AND PLEURISY , W/CC, > 17 352,950 14 SPECIFIC CEREBROVASCUALR DISORDERS EXCEPT TIA 334,849 430 PSYCHOSES 254,685

Online disease management of diabetes: engaging and motivating patients online with enhanced resources-diabetes (EMPOWER-D), a randomized controlled trial.

PubMed

Tang, Paul C; Overhage, J Marc; Chan, Albert Solomon; Brown, Nancy L; Aghighi, Bahar; Entwistle, Martin P; Hui, Siu Lui; Hyde, Shauna M; Klieman, Linda H; Mitchell, Charlotte J; Perkins, Anthony J; Qureshi, Lubna S; Waltimyer, Tanya A; Winters, Leigha J; Young, Charles Y

2013-05-01

To evaluate an online disease management system supporting patients with uncontrolled type 2 diabetes. Engaging and Motivating Patients Online With Enhanced Resources for Diabetes was a 12-month parallel randomized controlled trial of 415 patients with type 2 diabetes with baseline glycosylated hemoglobin (A1C) values ≥7.5% from primary care sites sharing an electronic health record. The intervention included: (1) wirelessly uploaded home glucometer readings with graphical feedback; (2) comprehensive patient-specific diabetes summary status report; (3) nutrition and exercise logs; (4) insulin record; (5) online messaging with the patient's health team; (6) nurse care manager and dietitian providing advice and medication management; and (7) personalized text and video educational 'nuggets' dispensed electronically by the care team. A1C was the primary outcome variable. Compared with usual care (UC, n=189), patients in the intervention (INT, n=193) group had significantly reduced A1C at 6 months (-1.32% INT vs -0.66% UC; p<0.001). At 12 months, the differences were not significant (-1.14% INT vs -0.95% UC; p=0.133). In post hoc analysis, significantly more INT patients had improved diabetes control (>0.5% reduction in A1C) than UC patients at 12 months (69.9 (95% CI 63.2 to 76.5) vs 55.4 (95% CI 48.4 to 62.5); p=0.006). A nurse-led, multidisciplinary health team can manage a population of diabetic patients in an online disease management program. INT patients achieved greater decreases in A1C at 6 months than UC patients, but the differences were not sustained at 12 months. More INT than UC patients achieved improvement in A1C (>0.5% decrease). Trial registered in clinical trials.gov: #NCT00542204.

Online disease management of diabetes: Engaging and Motivating Patients Online With Enhanced Resources-Diabetes (EMPOWER-D), a randomized controlled trial

PubMed Central

Tang, Paul C; Overhage, J Marc; Chan, Albert Solomon; Brown, Nancy L; Aghighi, Bahar; Entwistle, Martin P; Hui, Siu Lui; Hyde, Shauna M; Klieman, Linda H; Mitchell, Charlotte J; Perkins, Anthony J; Qureshi, Lubna S; Waltimyer, Tanya A; Winters, Leigha J; Young, Charles Y

2013-01-01

Objective To evaluate an online disease management system supporting patients with uncontrolled type 2 diabetes. Materials and methods Engaging and Motivating Patients Online With Enhanced Resources for Diabetes was a 12-month parallel randomized controlled trial of 415 patients with type 2 diabetes with baseline glycosylated hemoglobin (A1C) values ≥7.5% from primary care sites sharing an electronic health record. The intervention included: (1) wirelessly uploaded home glucometer readings with graphical feedback; (2) comprehensive patient-specific diabetes summary status report; (3) nutrition and exercise logs; (4) insulin record; (5) online messaging with the patient's health team; (6) nurse care manager and dietitian providing advice and medication management; and (7) personalized text and video educational ‘nuggets’ dispensed electronically by the care team. A1C was the primary outcome variable. Results Compared with usual care (UC, n=189), patients in the intervention (INT, n=193) group had significantly reduced A1C at 6 months (−1.32% INT vs −0.66% UC; p<0.001). At 12 months, the differences were not significant (−1.14% INT vs −0.95% UC; p=0.133). In post hoc analysis, significantly more INT patients had improved diabetes control (>0.5% reduction in A1C) than UC patients at 12 months (69.9 (95% CI 63.2 to 76.5) vs 55.4 (95% CI 48.4 to 62.5); p=0.006). Conclusions A nurse-led, multidisciplinary health team can manage a population of diabetic patients in an online disease management program. INT patients achieved greater decreases in A1C at 6 months than UC patients, but the differences were not sustained at 12 months. More INT than UC patients achieved improvement in A1C (>0.5% decrease). Trial registered in clinical trials.gov: #NCT00542204 PMID:23171659

Effectiveness of a new tool for self-evaluation of adherence to antimuscarinic drug treatment in older patients of both sexes with urge incontinence.

PubMed

Kosilov, Kirill; Loparev, Sergay; Kuzina, Irina; Kosilova, Liliya; Ivanovskaya, Marina; Prokofyeva, Alexandra

2018-01-01

The present study was a comparison of the validity of the Medication Adherence Self-Report Inventory (MASRI) questionnaire with other methods of assessing adherence to antimuscarinic drugs treatment in older patients with urge incontinence. The experiment involved 733 men and women aged >65 years who had noted no less than one urge incontinence episode per day. At the beginning of the experiment, and after 4, 8 and 12 weeks, their adherence to treatment was monitored using the MASRI. The construct validity of the tool was confirmed by data on the correlation of the percentage of non-adherent patients according to the MASRI and the percentage of patients having a belief barrier on the Brief Medication Questionnaire screen (r = 0.89, P ≤ 0.01; r = 0.91, P ≤ 0.01; and r = 0.91, P ≤ 0.05 at the 4th, 8th and 12th week of the follow up). The hypothesis of competitive validity was supported by comparing the percentage of non-adherent patients according to the MASRI and the number of missed doses on the Brief Medication Questionnaire screen (r = 0.94, P ≤ 0.01; r = 0.85, P ≤ 0.05; and r = 0.7, P ≤ 0.05), and according to a visual count of pills. The area under the curve at the 4th, 8 th , and 12th week was 0.95 ± 0.04, 0.92 ± 0.03 and 0.94 ± 0.04, respectively. The MASRI questionnaire has high validity, and is effective for evaluating adherence to treatment among older patients with urge incontinence taking antimuscarinic drugs. Using the MASRI would imply lower costs and greater availability of diagnostics, and it is the tool of choice in clinical practice. Geriatr Gerontol Int 2018; 18: 115-122. © 2017 Japan Geriatrics Society.

Molecular basis for the interaction between Integrator subunits IntS9 and IntS11 and its functional importance.

PubMed

Wu, Yixuan; Albrecht, Todd R; Baillat, David; Wagner, Eric J; Tong, Liang

2017-04-25

The metazoan Integrator complex (INT) has important functions in the 3'-end processing of noncoding RNAs, including the uridine-rich small nuclear RNA (UsnRNA) and enhancer RNA (eRNA), and in the transcription of coding genes by RNA polymerase II. The INT contains at least 14 subunits, but its molecular mechanism of action is poorly understood, because currently there is little structural information about its subunits. The endonuclease activity of INT is mediated by its subunit 11 (IntS11), which belongs to the metallo-β-lactamase superfamily and is a paralog of CPSF-73, the endonuclease for pre-mRNA 3'-end processing. IntS11 forms a stable complex with Integrator complex subunit 9 (IntS9) through their C-terminal domains (CTDs). Here, we report the crystal structure of the IntS9-IntS11 CTD complex at 2.1-Å resolution and detailed, structure-based biochemical and functional studies. The complex is composed of a continuous nine-stranded β-sheet with four strands from IntS9 and five from IntS11. Highly conserved residues are located in the extensive interface between the two CTDs. Yeast two-hybrid assays and coimmunoprecipitation experiments confirm the structural observations on the complex. Functional studies demonstrate that the IntS9-IntS11 interaction is crucial for the role of INT in snRNA 3'-end processing.

Effect of an internal coating technique on tensile bond strengths of resin cements to zirconia ceramics.

PubMed

Kitayama, Shuzo; Nikaido, Toru; Maruoka, Rena; Zhu, Lei; Ikeda, Masaomi; Watanabe, Akihiko; Foxton, Richard M; Miura, Hiroyuki; Tagami, Junji

2009-07-01

This study was conducted to enhance the tensile bond strengths of resin cements to zirconia ceramics. Fifty-six zirconia ceramic specimens (Cercon Base) and twenty-eight silica-based ceramic specimens (GN-1, GN-1 Ceramic Block) were air-abraded using alumina. Thereafter, the zirconia ceramic specimens were divided into two subgroups of 28 each according to the surface pretreatment; no pretreatment (Zr); and the internal coating technique (INT). For INT, the surface of zirconia was coated by fusing silica-based ceramics (Cercon Ceram Kiss). Ceramic surfaces were conditioned with/without a silane coupling agent followed by bonding with one of two resin cements; Panavia F 2.0 (PF) and Superbond C&B (SB). After 24 hours storage in water, the tensile bond strengths were tested (n=7). For both PF and SB, silanization significantly improved the bond strength to GN-1 and INT (p<0.05). The INT coating followed by silanizaton demonstrated enhancement of bonding to zirconia ceramics.

Forecasting landslide activations by means of GA-SAKe. An example of application to three case studies in Calabria (Southern Italy)

NASA Astrophysics Data System (ADS)

Iovine, Giulio G. R.; De Rango, Alessio; Gariano, Stefano L.; Terranova, Oreste G.

2016-04-01

GA-SAKe - the Genetic-Algorithm based release of the hydrological model SAKe (Self Adaptive Kernel) - allows to forecast the timing of activation of landslides [1, 2], based on dates of landslide activations and rainfall series. The model can be applied to either single or set of similar landslides in a homogeneous context. Calibration of the model is performed through Genetic-Algorithm, and provides families of optimal, discretized solutions (kernels) that maximize the fitness function. The mobility functions are obtained through convolution of the optimal kernels with rain series. The shape of the kernel, including its base time, is related to magnitude of the landslide and hydro-geological complexity of the slope. Once validated, the model can be applied to estimate the timing of future landslide activations in the same study area, by employing measured or forecasted rainfall. GA-SAKe is here employed to analyse the historical activations of three rock slides in Calabria (Southern Italy), threatening villages and main infrastructures. In particular: 1) the Acri-Serra di Buda case, developed within a Sackung, involving weathered crystalline and metamorphic rocks; for this case study, 6 dates of activation are available; 2) the San Fili-Uncino case, developed in clay and conglomerate overlaying gneiss and biotitic schist; for this case study, 7 dates of activation are available [2]; 3) the San Benedetto Ullano-San Rocco case, developed in weathered metamorphic rocks; for this case study, 3 dates of activation are available [1, 3, 4, 5]. The obtained results are quite promising, given the high performance of the model against slope movements characterized by numerous historical activations. Obtained results, in terms of shape and base time of the kernels, are compared by taking into account types and sizes of the considered case studies, and involved rock types. References [1] Terranova O.G., Iaquinta P., Gariano S.L., Greco R. & Iovine G. (2013) In: Landslide Science and Practice, Margottini, Canuti, Sassa (Eds.), Vol. 3, pp.73-79. [2] Terranova O.G., Gariano S.L., Iaquinta P. & Iovine G.G.R. (2015). Geosci. Model Dev., 8, 1955-1978. [3] Iovine G., Iaquinta P. & Terranova O. (2009). In Anderssen, Braddock & Newham (Eds.), Proc. 18th World IMACS Congr. and MODSIM09 Int. Congr. on Modelling and Simulation, pp. 2686-2693. [4] Iovine G., Lollino P., Gariano S.L. & Terranova O.G. (2010). NHESS, 10, 2341-2354. [5] Capparelli G., Iaquinta P., Iovine G., Terranova O.G. & Versace P. (2012). Natural Hazards, 61(1), pp.247-256.

The effects of short work vs. longer work periods within intermittent exercise on V̇o2p kinetics, muscle deoxygenation, and energy system contribution.

PubMed

McCrudden, Michael C; Keir, Daniel A; Belfry, Glen R

2017-06-01

We examined the effects of inserting 3-s recovery periods during high-intensity cycling exercise at 25-s and 10-s intervals on pulmonary oxygen uptake (V̇o 2p ), muscle deoxygenation [deoxyhemoglobin (HHb)], their associated kinetics (τ), and energy system contributions. Eleven men (24 ± 3 yr) completed two trials of three cycling protocols: an 8-min continuous protocol (CONT) and two 8-min intermittent exercise protocols with work-to-rest periods of 25 s to 3 s (25INT) and 10 s to 3 s (10INT). Each protocol began with a step-transition from a 20-W baseline to a power output (PO) of 60% between lactate threshold and maximal V̇o 2p (Δ60). This PO was maintained for 8 min in CONT, whereas 3-s periods of 20-W cycling were inserted every 10 s and 25 s after the transition to Δ60 in 10INT and 25INT, respectively. Breath-by-breath gas exchange measured by mass spectrometry and turbine and vastus lateralis [HHb] measured by near-infrared spectroscopy were recorded throughout. Arterialized-capillary lactate concentration ([Lac - ]) was obtained before and 2 min postexercise. The τV̇o 2p was lowest ( P < 0.05) for 10INT (24 ± 4 s) and 25INT (23 ± 5 s) compared with CONT (28 ± 4 s), whereas HHb kinetics did not differ ( P > 0.05) between conditions. Postexercise [Lac - ] was lowest ( P < 0.05) for 10INT (7.0 ± 1.7 mM), was higher for 25INT (10.3 ± 1.9 mM), and was greatest in CONT (14.3 ± 3.1 mM). Inserting 3-s recovery periods during heavy-intensity exercise speeded V̇o 2p kinetics and reduced overall V̇o 2p , suggesting an increased reliance on PCr-derived phosphorylation during the work period of INT compared with an identical PO performed continuously. NEW & NOTEWORTHY We report novel observations on the effects of differing heavy-intensity work durations between 3-s recovery periods on pulmonary oxygen uptake (V̇o 2p ) kinetics, muscle deoxygenation, and energy system contributions. Relative to continuous exercise, V̇o 2p kinetics are faster in intermittent exercise, and increased frequency of 3-s recovery periods improves microvascular O 2 delivery and reduces V̇o 2p and arterialized-capillary lactate concentration. The metabolic burden of identical intensity work is altered when performed intermittently vs. continuously. Copyright © 2017 the American Physiological Society.

Topological T-duality via Lie algebroids and Q-flux in Poisson-generalized geometry

NASA Astrophysics Data System (ADS)

Asakawa, Tsuguhiko; Muraki, Hisayoshi; Watamura, Satoshi

2015-10-01

It is known that the topological T-duality exchanges H- and F-fluxes. In this paper, we reformulate the topological T-duality as an exchange of two Lie algebroids in the generalized tangent bundle. Then, we apply the same formulation to the Poisson-generalized geometry, which is introduced [T. Asakawa, H. Muraki, S. Sasa and S. Watamura, Int. J. Mod. Phys. A 30, 1550097 (2015), arXiv:1408.2649 [hep-th

Ada (Trade Name) Bibliography. Volume 2.

DTIC Science & Technology

1984-03-01

for every journal. The publisher information V,.0 appears if the document is a textbook. N % Xle r , , % 1= &-6 Ada Bibliography Volume 11 9 3. DOCUMENT...THE ADA LkNGUAGE SYSTEM PROJECT RAKITIN. STEVEN R . 6TH INT’L CONF ON SOFTWARE ENGINEERING: POSTER SESSION, PP. 49-50. 09/16/82 This paper discusses...VALIDATION AVAILABLE FROM: NATL.TECHNCL INF.SVC.5285 PORT ROYAL RD,SPRINGFIELD.VA SPONSORS: U.S.ARMY,COMMUNICATIONS R & D COMND, FT.MONMOUTH, NJ DOCUMENT

Fracture panfaciale: un challenge thérapeutique: à propos d'une observation et revue de la littérature

PubMed Central

Fassih, Malika; Nassik, Hicham; Abada, Mourad Nafaa Redallah; Rouadi, Sami; Mahta, Mohamed; Roubal, Mohamed; Essaadi, Mustapha; El Kadiri, Mohamed Fatmi

2015-01-01

La gestion des traumatismes de la face a subi plusieurs progrès dans la dernière décennie. Avec l'avènement de la tomodensitométrie bi- et tridimensionnelle, qui permet de dresser une cartographie précise des lésions osseuses, le développement du matériel d'ostéosynthèse, et les procédés de réduction des fractures. L'objectif est la restauration totale de la forme et la fonction de la face, seul garant pour empêcher la survenue de préjudices esthétiques et fonctionnels. Nous rapportons l'observation de Mme assal khadija, âgée de 38 ans, admise le 25 Aout 2010, au service des urgences d'ORL et maxillo-faciales, à l'hôpital 20 aout de Casablanca, victime d'un AVP, occasionnant un traumatisme facial grave, avec un important délabrement de la face, et asphyxie. Une trachéotomie a été réalisée en urgence. Le bilan lésionnel a objectivé un important fracas du massif facial intéressant l’étage supérieure, moyen et inférieur. Dans l'immédiat, un parage a été réalisé sous anesthésie générale, la réparation des parties molles délabrées a été effectuée en endobuccale (vestibules, langue et plancher buccal) et pour les téguments de la face. Une semaine après, la patiente a été reprise pour la reconstruction du massif facial, nous avons opté pour le «inside-out, de bas en haut" pour la réduction des fractures. Nous avons procédé à la fixation de la mandibule qui a précédé la reconstruction du maxillaire, de la pyramide nasale, et de l'orbite. L’évolution a été marquée par l'apparition d'un orostome, qui fera l'objet après tarissement de l'infection, d'une réparation grâce à un lambeau myocutané, et une nécrose cutanée de la région zygomatique laissée à la cicatrisation dirigée. Toutes les lésions traumatiques de la face ont des répercussions esthétiques et fonctionnelles à moyen et long termes, dont le degré dépend de la qualité de la prise en charge, qui étant la plus précoce et la plus complète possible avant la consolidation des fractures est le meilleur garant d'un résultat satisfaisant à long terme. PMID:27386025

A comparison of 16 weeks of continuous vs intermittent exercise training in chronic heart failure patients.

PubMed

Smart, Neil A; Steele, Michael

2012-01-01

The authors compared the effects of continuous (CON) and intermittent (INT) exercise training programs on functional capacity, quality of life (QOL), and cardiac function in 23 congestive heart failure patients. Patients were randomized to CON exercise training (n=13; aged 66±7 years; peak oxygen consumption [VO(2)], 12.4±2.5 mL/kg/min; weight, 83±12 kg; left ventricular ejection fraction [LVEF], 29.5%±7.2%) or INT exercise training (n=10; aged 59±11 years; VO(2), 12.2±6.5 mL/kg/min; weight, 87±24 kg; LVEF 27%±7.9%). These groups completed 16 weeks of stationary cycling at 70% VO(2) thrice weekly for 30 minutes continuously or 60 minutes (60 seconds work:60 seconds rest) intermittently; both groups completed the same absolute volume of work. Three QOL questionnaire responses, VO(2), LVEF, and regional tissue Doppler were quantified. After exercise training, VO(2) increased by 13% in the CON group (P=.12) and significantly by 21% in the INT group (P=.03), although not significantly between the groups (P=.72). In the CON group, Minnesota Living With Heart Failure score improved at 16 weeks (P=.02), while in the INT group, Hare-Davis scores improved (P=.02). Cardiac volumes, resting and peak LVEF, contractile reserve, and tissue velocities were all unchanged from baseline. Intermittent exercise may improve functional capacity to a greater extent than continuous exercise. QOL changes were variable between groups. © 2011 Wiley Periodicals, Inc.

Integrator complex plays an essential role in adipose differentiation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Otani, Yuichiro; Nakatsu, Yusuke; Sakoda, Hideyuki

2013-05-03

Highlights: •IntS6 and IntS11 are subunits of the Integrator complex. •Expression levels of IntS6 and IntS11 were very low in 3T3-L1 fibroblast. •IntS6 and IntS11 were upregulated during adipose differentiation. •Suppression of IntS6 or IntS11 expression inhibited adipose differentiation. -- Abstract: The dynamic process of adipose differentiation involves stepwise expressions of transcription factors and proteins specific to the mature fat cell phenotype. In this study, it was revealed that expression levels of IntS6 and IntS11, subunits of the Integrator complex, were increased in 3T3-L1 cells in the period when the cells reached confluence and differentiated into adipocytes, while being reducedmore » to basal levels after the completion of differentiation. Suppression of IntS6 or IntS11 expression using siRNAs in 3T3-L1 preadipocytes markedly inhibited differentiation into mature adipocytes, based on morphological findings as well as mRNA analysis of adipocyte-specific genes such as Glut4, perilipin and Fabp4. Although Pparγ2 protein expression was suppressed in IntS6 or IntS11-siRNA treated cells, adenoviral forced expression of Pparγ2 failed to restore the capacity for differentiation into mature adipocytes. Taken together, these findings demonstrate that increased expression of Integrator complex subunits is an indispensable event in adipose differentiation. Although further study is necessary to elucidate the underlying mechanism, the processing of U1, U2 small nuclear RNAs may be involved in cell differentiation steps.« less

7. Historic American Buildings Survey Arthur C. Haskell, Photographer Aug. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Historic American Buildings Survey Arthur C. Haskell, Photographer Aug. 30, 1938 (g) INT.- MANTEL, SOUTHWEST ROOM, 1st. FLOOR - Captain William Wildes House, 872 Commercial Street, Weymouth, Norfolk County, MA

Translating Healthy Living Messages to Postpartum Women and Their Partners After Gestational Diabetes (GDM): Body Habitus, A1C, Lifestyle Habits, and Program Engagement Results From the Families Defeating Diabetes (FDD) Randomized Trial.

PubMed

McManus, R; Miller, D; Mottola, M; Giroux, I; Donovan, L

2017-01-01

The Families Defeating Diabetes intervention evaluated a postpartum healthy living program for women with recent gestational diabetes mellitus (GDM). Randomized controlled trial. Tertiary centers in London, Calgary, and Victoria, Canada. Women with GDM and partners; 46% of eligible maternal participants agreed to participate. Interventional (INT) participants received a healthy living seminar at 3 months; access to a walking group/Website; biweekly e-mails. Control (CON) participants received a contemporary postpartum diabetes prevention handout. Maternal, partner, and offspring demographics at baseline, 3, and 12 months. Percentages of women losing ≥7% of postpartum weight were compared by χ 2 testing; body habitus comparisons by analysis of covariance (ANCOVA); maternal A1C comparisons by unpaired t tests; participant outcome associations by Pearson correlation coefficients. Maternal participants were 170 (89 INT and 81 CON) with 63 partners (30 INT and 33 CON); 103 (73 maternal; 30 partners) were lost to follow-up; 57% of maternal participants completed 12 months; 33% INT women (n = 50) lost ≥7% weight versus 25% CON women (n = 47), P = .43. Interventional participant results did not correlate with accession of study elements. Maternal completion was significantly associated with partner involvement, breastfeeding, higher income, and education. Paternal weights correlated significantly with maternal and offspring weights. Families Defeating Diabetes outcomes were not significantly different for INT maternal or paternal participants versus CON participants. Secondary outcomes of future value included statistically significant positive associations between paternal participation, socioeconomic indicators, and maternal study completion, significant correlations between maternal, paternal, and offspring weights as well as insights into study component engagement.

Remote Sensing Studies of Anorthosite Deposits on the Moon

NASA Astrophysics Data System (ADS)

Hawke, B. R.; Taylor, G. J.; Lucey, P. G.; Peterson, C. A.; Blewett, D. T.; Spudis, P. D.

1995-09-01

Introduction: In recent years, we have been conducting a variety of remote sensing studies of lunar basin and crater deposits in order to determine the composition of surface units and to investigate the stratigraphy of the lunar crust [1-6]. Special attention has been given to determining the distribution and modes of occurrence of pure anorthosite (plagioclase >90%) in order to answer the critical question of whether or not the lunar crust is enriched in plagioclase. In previous studies, we have utilized telescopic near-infrared spectra to determine the lithology of relatively small areas (2-10 km) of the lunar surface. Now, high resolution multispectral images are available from the Galileo and Clementine missions. We are currently utilizing a variety of techniques to extract compositional information from these new data sets. Chief among these is the production of FeO abundance maps from Clementine and Galileo multispectral images using the method presented by Lucey et al. [7]. Distribution and Modes of Occurrence: Orientale Basin region. With the exception of the Inner Rook massifs, all the highland units associated with the Orientale Basin appear to be composed of either noritic anorthosite or anorthositic norite. Our spectral data indicate that the Inner Rook ring is composed of pure anorthosite [1,2]. Relatively low (<4%) FeO values are exhibited by most portions of this mountain range. Grimaldi Basin region. Spectra obtained for the inner ring of Grimaldi indicate that portions of this ring are composed of pure anorthosite. Low FeO values are also displayed by segments of the inner ring. Other highlands units in the Grimaldi region are composed of more mafic material [2,5]. Humorum Basin region. At least a portion of the inner ring of Humorum is composed of anorthosite [2,6]. However, Galileo and Clementine data demonstrate that the entire ring is not composed of anorthosite, and no anorthosites have yet been identified on the outer Humorum rings. Nectaris Basin region. While noritic anorthosites and anorthositic norites are the dominant rock types in the region, anorthosites have now been located on, or very near, the four innermost rings of Nectaris [3,4,8]. Relatively low (<4%) FeO values are associated with Kant and Cyrillus A craters. Crisium Basin region. A recent spectral survey of the Crisium region failed to locate pure anorthosite deposits [9]. However, an analysis of Galileo multispectral imagery and FeO map has shown that small exposures of pure anorthosite occur near Proclus crater and in the vicinity of Geminus crater. Other Occurrences. Recent studies utilizing both Earth-based spectra and Galileo SSI data suggest that pure anorthosite is exposed within Goldschmidt crater in the northern highlands [10]. Anorthosites have also been identified in the central peaks of Alphonsus and Petavius craters [8,11]. Very recently, Clementine near-IR images were used to show that anorthosite was present in the central peak of Aristarchus crater [12]. In every instance, the anorthosites on the nearside were exposed from beneath a shallower near-surface layer of more pyroxene-rich material. Recent results from the Clementine mission indicate that pure anorthosite may be quite abundant on certain farside surfaces [7]. References: [1] Spudis P. et al. (1984) Proc. LPSC 15th, in JGR, 89, C197. [2] Hawke B. et al. (1991) GRL, 18, 2141. [3] Spudis P. et al. (1989) Proc. LPSC 19th, 51. [4] Hawke B. et al. (1986) NASA TM-88383, 526. [5] Peterson C. et al. (1995) GRL, in press. [6] Hawke B. et al. (1993) GRL, 20, 419. [7] Lucey P. et al. (1995) Science, 268, 1150. [8] Pieters C. (1986) Rev. Geophys., 24, 557. [9] Blewett D. et al. (1995) GRL, in press. [10] Pieters C. et al. (1993) LPS XXIV, 1141. [11] Coombs C. et al. (1990) Proc. LPS, Vol. 20, 161. [12] McEwen A. et al. (1994) Science, 1858.

Abundance of antibiotic resistance genes in environmental bacteriophages.

PubMed

Anand, Taruna; Bera, Bidhan Ch; Vaid, Rajesh K; Barua, Sanjay; Riyesh, Thachamvally; Virmani, Nitin; Hussain, Mubarik; Singh, Raj K; Tripathi, Bhupendra N

2016-12-01

The ecosystem is continuously exposed to a wide variety of antimicrobials through waste effluents, agricultural run-offs and animal-related and anthropogenic activities, which contribute to the spread of antibiotic resistance genes (ARGs). The contamination of ecosystems with ARGs may create increased opportunities for their transfer to naive microbes and eventually lead to entry into the human food chain. Transduction is a significant mechanism of horizontal gene transfer in natural environments, which has traditionally been underestimated as compared to transformation. We explored the presence of ARGs in environmental bacteriophages in order to recognize their contribution in the spread of ARGs in environmental settings. Bacteriophages were isolated against environmental bacterial isolates, purified and bulk cultured. They were characterized, and detection of ARG and intI genes including blaTEM, blaOXA-2, intI1, intI2, intI3, tetA and tetW was carried out by PCR. This study revealed the presence of various genes [tetA (12.7 %), intI1 (10.9 %), intI2 (10.9 %), intI3 (9.1 %), tetW (9.1 %) and blaOXA-2 (3.6 %)] and blaTEM in a significantly higher proportion (30.9 %). blaSHV, blaOXA-1, tetO, tetB, tetG, tetM and tetS were not detected in any of the phages. Soil phages were the most versatile in terms of ARG carriage. Also, the relative abundance of tetA differed significantly vis-à-vis source. The phages from organized farms showed varied ARGs as compared to the unorganized sector, although blaTEM ARG incidences did not differ significantly. The study reflects on the role of phages in dissemination of ARGs in environmental reservoirs, which may provide an early warning system for future clinically relevant resistance mechanisms.

Intelligent "Peptide-Gathering Mechanical Arm" Tames Wild "Trojan-Horse" Peptides for the Controlled Delivery of Cancer Nanotherapeutics.

PubMed

Shi, Nian-Qiu; Li, Yan; Zhang, Yong; Shen, Nan; Qi, Ling; Wang, Shu-Ran; Qi, Xian-Rong

2017-12-06

Cell-penetrating peptides (CPPs), also called "Trojan-Horse" peptides, have been used for facilitating intracellular delivery of numerous diverse cargoes and even nanocarriers. However, the lack of targeting specificity ("wildness" or nonselectivity) of CPP-nanocarriers remains an intractable challenge for many in vivo applications. In this work, we used an intelligent "peptide-gathering mechanical arm" (Int PMA) to curb CPPs' wildness and enhance the selectivity of R 9 -liposome-based cargo delivery for tumor targeting. The peptide NGR, serving as a cell-targeting peptide for anchoring, and peptide PLGLAG, serving as a substrate peptide for deanchoring, were embedded in the Int PMA motif. The Int PMA construct was designed to be sensitive to tumor microenvironmental stimuli, including aminopeptidase N (CD13) and matrix metalloproteinases (MMP-2/9). Moreover, Int PMA could be specifically recognized by tumor tissues via CD13-mediated anchoring and released for cell entry by MMP-2/9-mediated deanchoring. To test the Int PMA design, a series of experiments were conducted in vitro and in vivo. Functional conjugates Int PMA-R 9 -poly(ethylene glycol) (PEG) 2000 -distearoylphosphatidyl-ethanolamine (DSPE) and R 9 -PEG 2000 -DSPE were synthesized by Michael addition reaction and were characterized by thin-layer chromatography and matrix-assisted laser desorption ionization-time-of-flight mass spectrometry. The Int PMA-R 9 -modified doxorubicin-loaded liposomes (Int PMA-R 9 -Lip-DOX) exhibited a proper particle diameter (approximately 155 nm) with in vitro sustained release characteristics. Cleavage assay showed that Int PMA-R 9 peptide molecules could be cleaved by MMP-2/9 for completion of deanchoring. Flow cytometry and confocal microscopy studies indicated that Int PMA-R 9 -Lip-DOX can respond to both endogenous and exogenous stimuli in the presence/absence of excess MMP-2/9 and MMP-2/9 inhibitor (GM6001) and effectively function under competitive receptor-binding conditions. Moreover, Int PMA-R 9 -Lip-DOX generated more significant subcellular dispersions that were especially evident within endoplasmic reticulum (ER) and Golgi apparatus. Notably, Int PMA-R 9 -Lip-DOX could induce enhanced apoptosis, during which caspase 3/7 might be activated. In addition, Int PMA-R 9 -Lip-DOX displayed enhanced in vitro and in vivo antitumor efficacy versus "wild" R 9 -Lip-DOX. On the basis of investigations at the molecular level, cellular level, and animals' level, the control of Int PMA was effective and promoted selective delivery of R 9 -liposome cargo to the target site and reduced nonspecific uptake. This Int PMA-controlled strategy based on aminopeptidase-guided anchoring and protease-triggered deanchoring effectively curbed the wildness of CPPs and bolstered their effectiveness for in vivo delivery of nanotherapeutics. The specific nanocarrier delivery system used here could be adapted using a variety of intelligent designs based on combinations of multifunctional peptides that would specifically and preferentially bind to tumors versus nontumor tissues for tumor-localized accumulation in vivo. Thus, CPPs have a strong advantage for the development of intelligent nanomedicines for targeted tumor therapy.

Changes in diaphragm muscle collagen gene expression after acute unilateral denervation

NASA Technical Reports Server (NTRS)

Gosselin, L. E.; Sieck, G. C.; Aleff, R. A.; Martinez, D. A.; Vailas, A. C.

1995-01-01

The purpose of the present study was to examine the effects of acute (3 days) unilateral diaphragm denervation (DNV) on 1) levels of alpha 1(I) and alpha 1(III) procollagen mRNA; 2) collagen concentration [hydroxyproline (HYP)]; 3) amount of the nonreducible collagen cross-link hydroxylysylpyridinoline (HP); and 4) the passive force-length relationship of the muscle. The levels of alpha 1(I) and alpha 1(III) procollagen mRNA, HYP concentration, and amount of HP were measured in muscle segments from the midcostal region of DNV and intact (INT) hemidiaphragms of adult male Fischer 344 rats (250-300 g). The in vitro passive force-length relationship of DNV and INT hemidiaphragm was determined by lengthening and shortening the diaphragm muscle segments from 85 to 115% of optimal length at a constant velocity (0.6 optimal length/s). Three days after DNV, the level of alpha 1(I) procollagen mRNA was increased over 15-fold in the DNV hemidiaphragm compared with INT (P < 0.05), whereas the level of alpha 1(III) procollagen mRNA was increased by approximately sixfold in the DNV hemidiaphragm compared with INT (P < 0.05). Collagen (HYP) concentration did not differ between groups, averaging 8.7 and 8.9 micrograms/mg dry wt for the DNV and INT hemidiaphragms, respectively. In addition, there was no difference in the amount of the mature nonreducible collagen cross-link HP between the DNV and INT hemidiaphragms (0.66 vs. 0.76 mole HP/mole collagen, respectively). The amount of passive force developed during lengthening did not differ between DNV and INT hemidiaphragms. These data indicate that acute DNV of the hemidiaphragm is associated with an increase in the mRNA level of the two principal fibrillar collagen phenotypes in skeletal muscle. However, despite extensive muscle remodeling, the passive force-length relationship of the DNV hemidiaphragm is unaffected compared with the INT muscle.

Comment on "Radiocarbon Calibration Curve Spanning 0 to 50,000 Years B.P. Based on Paired 230Th/234U/238U and 14C Dates on Pristine Corals" by R.G. Fairbanks, R. A. Mortlock, T.-C. Chiu, L. Cao, A. Kaplan, T. P. Guilderson, T. W. Fairbanks, A. L. Bloom, P

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reimer, P J; Baillie, M L; Bard, E

2005-10-02

Radiocarbon calibration curves are essential for converting radiocarbon dated chronologies to the calendar timescale. Prior to the 1980's numerous differently derived calibration curves based on radiocarbon ages of known age material were in use, resulting in ''apples and oranges'' comparisons between various records (Klein et al., 1982), further complicated by until then unappreciated inter-laboratory variations (International Study Group, 1982). The solution was to produce an internationally-agreed calibration curve based on carefully screened data with updates at 4-6 year intervals (Klein et al., 1982; Stuiver and Reimer, 1986; Stuiver and Reimer, 1993; Stuiver et al., 1998). The IntCal working group hasmore » continued this tradition with the active participation of researchers who produced the records that were considered for incorporation into the current, internationally-ratified calibration curves, IntCal04, SHCal04, and Marine04, for Northern Hemisphere terrestrial, Southern Hemisphere terrestrial, and marine samples, respectively (Reimer et al., 2004; Hughen et al., 2004; McCormac et al., 2004). Fairbanks et al. (2005), accompanied by a more technical paper, Chiu et al. (2005), and an introductory comment, Adkins (2005), recently published a ''calibration curve spanning 0-50,000 years''. Fairbanks et al. (2005) and Chiu et al. (2005) have made a significant contribution to the database on which the IntCal04 and Marine04 calibration curves are based. These authors have now taken the further step to derive their own radiocarbon calibration extending to 50,000 cal BP, which they claim is superior to that generated by the IntCal working group. In their papers, these authors are strongly critical of the IntCal calibration efforts for what they claim to be inadequate screening and sample pretreatment methods. While these criticisms may ultimately be helpful in identifying a better set of protocols, we feel that there are also several erroneous and misleading statements made by these authors which require a response by the IntCal working group. Furthermore, we would like to comment on the sample selection criteria, pretreatment methods, and statistical methods utilized by Fairbanks et al. in derivation of their own radiocarbon calibration.« less

Spherical images and inextensible curved folding

NASA Astrophysics Data System (ADS)

Seffen, Keith A.

2018-02-01

In their study, Duncan and Duncan [Proc. R. Soc. London A 383, 191 (1982), 10.1098/rspa.1982.0126] calculate the shape of an inextensible surface folded in two about a general curve. They find the analytical relationships between pairs of generators linked across the fold curve, the shape of the original path, and the fold angle variation along it. They present two special cases of generator layouts for which the fold angle is uniform or the folded curve remains planar, for simplifying practical folding in sheet-metal processes. We verify their special cases by a graphical treatment according to a method of Gauss. We replace the fold curve by a piecewise linear path, which connects vertices of intersecting pairs of hinge lines. Inspired by the d-cone analysis by Farmer and Calladine [Int. J. Mech. Sci. 47, 509 (2005), 10.1016/j.ijmecsci.2005.02.013], we construct the spherical images for developable folding of successive vertices: the operating conditions of the special cases in Duncan and Duncan are then revealed straightforwardly by the geometric relationships between the images. Our approach may be used to synthesize folding patterns for novel deployable and shape-changing surfaces without need of complex calculation.

The structure and ordering of ɛ-MnO 2

NASA Astrophysics Data System (ADS)

Kim, Chang-Hoon; Akase, Zentaro; Zhang, Lichun; Heuer, Arthur H.; Newman, Aron E.; Hughes, Paula J.

2006-03-01

The presence of ɛ-MnO 2 as a major component of electrolytic manganese dioxide (EMD) has been demonstrated by a combined X-ray diffraction/transmission electron microscopy (TEM) study. ɛ-MnO 2 usually has a partially ordered defect NiAs structure containing 50% cation vacancies; these vacancies can be fully ordered by a low temperature (200 °C) heat treatment to form a pseudohexagonal but monoclinic superlattice. Numerous fine-scale anti-phase domain boundaries are present in ordered ɛ-MnO 2 and cause extensive peak broadening and a massive shift of a very intense, 0.37 nm superlattice peak. This suggests a radically different explanation of the ubiquitous, very broad ˜0.42 nm peak (˜21-22° 2 θ, Cu Kα radiation) in EMDs, which heretofore has been attributed to Ramsdellite containing numerous planar defects. This work confirms the multi-phase model of equiaxed EMDs proposed by Heuer et al. [ITE Lett. 1(6) (2000) B50; Proc. Seventh Int. Symp. Adv. Phys. Fields 92 (2001)], rather than the defective single-phase model of Chabre and Pannetier [Prog. Solid State Chem. 23 (1995) 1] and Bowden et al. [ITE Lett. 4(1) (2003) B1].

Severity of structural and functional right ventricular remodeling depends on training load in an experimental model of endurance exercise.

PubMed

Sanz-de la Garza, Maria; Rubies, Cira; Batlle, Montserrat; Bijnens, Bart H; Mont, Lluis; Sitges, Marta; Guasch, Eduard

2017-09-01

Arrhythmogenic right ventricular (RV) remodeling has been reported in response to regular training, but it remains unclear how exercise intensity affects the presence and extent of such remodeling. We aimed to assess the relationship between RV remodeling and exercise load in a long-term endurance training model. Wistar rats were conditioned to run at moderate (MOD; 45 min, 30 cm/s) or intense (INT; 60 min, 60 cm/s) workloads for 16 wk; sedentary rats served as controls. Cardiac remodeling was assessed with standard echocardiographic and tissue Doppler techniques, sensor-tip pressure catheters, and pressure-volume loop analyses. After MOD training, both ventricles similarly dilated (~16%); the RV apical segment deformation, but not the basal segment deformation, was increased [apical strain rate (SR): -2.9 ± 0.5 vs. -3.3 ± 0.6 s -1 , SED vs. MOD]. INT training prompted marked RV dilatation (~26%) but did not further dilate the left ventricle (LV). A reduction in both RV segments' deformation in INT rats (apical SR: -3.3 ± 0.6 vs. -3.0 ± 0.4 s -1 and basal SR: -3.3 ± 0.7 vs. -2.7 ± 0.6 s -1 , MOD vs. INT) led to decreased global contractile function (maximal rate of rise of LV pressure: 2.53 ± 0.15 vs. 2.17 ± 0.116 mmHg/ms, MOD vs. INT). Echocardiography and hemodynamics consistently pointed to impaired RV diastolic function in INT rats. LV systolic and diastolic functions remained unchanged in all groups. In conclusion, we showed a biphasic, unbalanced RV remodeling response with increasing doses of exercise: physiological adaptation after MOD training turns adverse with INT training, involving disproportionate RV dilatation, decreased contractility, and impaired diastolic function. Our findings support the existence of an exercise load threshold beyond which cardiac remodeling becomes maladaptive. NEW & NOTEWORTHY Exercise promotes left ventricular eccentric hypertrophy with no changes in systolic or diastolic function in healthy rats. Conversely, right ventricular adaptation to physical activity follows a biphasic, dose-dependent, and segmentary pattern. Moderate exercise promotes a mild systolic function enhancement at the right ventricular apex and more intense exercise impairs systolic and diastolic function. Copyright © 2017 the American Physiological Society.

Aerosol chemical composition in cloud events by high resolution time-of-flight aerosol mass spectrometry.

PubMed

Hao, Liqing; Romakkaniemi, Sami; Kortelainen, Aki; Jaatinen, Antti; Portin, Harri; Miettinen, Pasi; Komppula, Mika; Leskinen, Ari; Virtanen, Annele; Smith, James N; Sueper, Donna; Worsnop, Douglas R; Lehtinen, Kari E J; Laaksonen, Ari

2013-03-19

This study presents results of direct observations of aerosol chemical composition in clouds. A high-resolution time-of-flight aerosol mass spectrometer was used to make measurements of cloud interstitial particles (INT) and mixed cloud interstitial and droplet residual particles (TOT). The differences between these two are the cloud droplet residuals (RES). Positive matrix factorization analysis of high-resolution mass spectral data sets and theoretical calculations were performed to yield distributions of chemical composition of the INT and RES particles. We observed that less oxidized hydrocarbon-like organic aerosols (HOA) were mainly distributed into the INT particles, whereas more oxidized low-volatile oxygenated OA (LVOOA) mainly in the RES particles. Nitrates existed as organic nitrate and in chemical form of NH(4)NO(3). Organic nitrates accounted for 45% of total nitrates in the INT particles, in clear contrast to 26% in the RES particles. Meanwhile, sulfates coexist in forms of acidic NH(4)HSO(4) and neutralized (NH(4))(2)SO(4). Acidic sulfate made up 64.8% of total sulfates in the INT particles, much higher than 10.7% in the RES particles. The results indicate a possible joint effect of activation ability of aerosol particles, cloud processing, and particle size effects on cloud formation.

Accurate template-based modeling in CASP12 using the IntFOLD4-TS, ModFOLD6, and ReFOLD methods.

PubMed

McGuffin, Liam J; Shuid, Ahmad N; Kempster, Robert; Maghrabi, Ali H A; Nealon, John O; Salehe, Bajuna R; Atkins, Jennifer D; Roche, Daniel B

2018-03-01

Our aim in CASP12 was to improve our Template-Based Modeling (TBM) methods through better model selection, accuracy self-estimate (ASE) scores and refinement. To meet this aim, we developed two new automated methods, which we used to score, rank, and improve upon the provided server models. Firstly, the ModFOLD6_rank method, for improved global Quality Assessment (QA), model ranking and the detection of local errors. Secondly, the ReFOLD method for fixing errors through iterative QA guided refinement. For our automated predictions we developed the IntFOLD4-TS protocol, which integrates the ModFOLD6_rank method for scoring the multiple-template models that were generated using a number of alternative sequence-structure alignments. Overall, our selection of top models and ASE scores using ModFOLD6_rank was an improvement on our previous approaches. In addition, it was worthwhile attempting to repair the detected errors in the top selected models using ReFOLD, which gave us an overall gain in performance. According to the assessors' formula, the IntFOLD4 server ranked 3rd/5th (average Z-score > 0.0/-2.0) on the server only targets, and our manual predictions (McGuffin group) ranked 1st/2nd (average Z-score > -2.0/0.0) compared to all other groups. © 2017 Wiley Periodicals, Inc.

Single-molecule dataset (SMD): a generalized storage format for raw and processed single-molecule data.

PubMed

Greenfeld, Max; van de Meent, Jan-Willem; Pavlichin, Dmitri S; Mabuchi, Hideo; Wiggins, Chris H; Gonzalez, Ruben L; Herschlag, Daniel

2015-01-16

Single-molecule techniques have emerged as incisive approaches for addressing a wide range of questions arising in contemporary biological research [Trends Biochem Sci 38:30-37, 2013; Nat Rev Genet 14:9-22, 2013; Curr Opin Struct Biol 2014, 28C:112-121; Annu Rev Biophys 43:19-39, 2014]. The analysis and interpretation of raw single-molecule data benefits greatly from the ongoing development of sophisticated statistical analysis tools that enable accurate inference at the low signal-to-noise ratios frequently associated with these measurements. While a number of groups have released analysis toolkits as open source software [J Phys Chem B 114:5386-5403, 2010; Biophys J 79:1915-1927, 2000; Biophys J 91:1941-1951, 2006; Biophys J 79:1928-1944, 2000; Biophys J 86:4015-4029, 2004; Biophys J 97:3196-3205, 2009; PLoS One 7:e30024, 2012; BMC Bioinformatics 288 11(8):S2, 2010; Biophys J 106:1327-1337, 2014; Proc Int Conf Mach Learn 28:361-369, 2013], it remains difficult to compare analysis for experiments performed in different labs due to a lack of standardization. Here we propose a standardized single-molecule dataset (SMD) file format. SMD is designed to accommodate a wide variety of computer programming languages, single-molecule techniques, and analysis strategies. To facilitate adoption of this format we have made two existing data analysis packages that are used for single-molecule analysis compatible with this format. Adoption of a common, standard data file format for sharing raw single-molecule data and analysis outcomes is a critical step for the emerging and powerful single-molecule field, which will benefit both sophisticated users and non-specialists by allowing standardized, transparent, and reproducible analysis practices.

Fish and chips: implementation of a neural network model into computer chips to maximize swimming efficiency in autonomous underwater vehicles.

PubMed

Blake, R W; Ng, H; Chan, K H S; Li, J

2008-09-01

Recent developments in the design and propulsion of biomimetic autonomous underwater vehicles (AUVs) have focused on boxfish as models (e.g. Deng and Avadhanula 2005 Biomimetic micro underwater vehicle with oscillating fin propulsion: system design and force measurement Proc. 2005 IEEE Int. Conf. Robot. Auto. (Barcelona, Spain) pp 3312-7). Whilst such vehicles have many potential advantages in operating in complex environments (e.g. high manoeuvrability and stability), limited battery life and payload capacity are likely functional disadvantages. Boxfish employ undulatory median and paired fins during routine swimming which are characterized by high hydromechanical Froude efficiencies (approximately 0.9) at low forward speeds. Current boxfish-inspired vehicles are propelled by a low aspect ratio, 'plate-like' caudal fin (ostraciiform tail) which can be shown to operate at a relatively low maximum Froude efficiency (approximately 0.5) and is mainly employed as a rudder for steering and in rapid swimming bouts (e.g. escape responses). Given this and the fact that bioinspired engineering designs are not obligated to wholly duplicate a biological model, computer chips were developed using a multilayer perception neural network model of undulatory fin propulsion in the knifefish Xenomystus nigri that would potentially allow an AUV to achieve high optimum values of propulsive efficiency at any given forward velocity, giving a minimum energy drain on the battery. We envisage that externally monitored information on flow velocity (sensory system) would be conveyed to the chips residing in the vehicle's control unit, which in turn would signal the locomotor unit to adopt kinematics (e.g. fin frequency, amplitude) associated with optimal propulsion efficiency. Power savings could protract vehicle operational life and/or provide more power to other functions (e.g. communications).

Constrained low-rank matrix estimation: phase transitions, approximate message passing and applications

NASA Astrophysics Data System (ADS)

Lesieur, Thibault; Krzakala, Florent; Zdeborová, Lenka

2017-07-01

This article is an extended version of previous work of Lesieur et al (2015 IEEE Int. Symp. on Information Theory Proc. pp 1635-9 and 2015 53rd Annual Allerton Conf. on Communication, Control and Computing (IEEE) pp 680-7) on low-rank matrix estimation in the presence of constraints on the factors into which the matrix is factorized. Low-rank matrix factorization is one of the basic methods used in data analysis for unsupervised learning of relevant features and other types of dimensionality reduction. We present a framework to study the constrained low-rank matrix estimation for a general prior on the factors, and a general output channel through which the matrix is observed. We draw a parallel with the study of vector-spin glass models—presenting a unifying way to study a number of problems considered previously in separate statistical physics works. We present a number of applications for the problem in data analysis. We derive in detail a general form of the low-rank approximate message passing (Low-RAMP) algorithm, that is known in statistical physics as the TAP equations. We thus unify the derivation of the TAP equations for models as different as the Sherrington-Kirkpatrick model, the restricted Boltzmann machine, the Hopfield model or vector (xy, Heisenberg and other) spin glasses. The state evolution of the Low-RAMP algorithm is also derived, and is equivalent to the replica symmetric solution for the large class of vector-spin glass models. In the section devoted to result we study in detail phase diagrams and phase transitions for the Bayes-optimal inference in low-rank matrix estimation. We present a typology of phase transitions and their relation to performance of algorithms such as the Low-RAMP or commonly used spectral methods.

SAS FORMATS: USES AND ABUSES

EPA Science Inventory

SAS formats are a very powerful tool. They allow you to display the data in a more readable manner without modifying the data. They can also be used to group data into categories for use in various procedures like PROC FREQ, PROC TTEST, and PROC MEANS (as a class variable). ...

SAS FORMATS: USES AND ABUSES

EPA Science Inventory

SAS formats are a very powerful tool. They allow you to display the data in a more readable manner without modifying it. Formats can also be used to group data into categories for use in various procedures like PROC FREQ, PROC TTEST, and PROC MEANS (as a class variable). As ...

Meso-size Effect from Self-assembled Carbon Structures and Their Device Applications

DTIC Science & Technology

2013-08-23

electrical photoresponse from pentacene 1D disks and 2D wires, and 3) dramatic increase of solubility in water of zinc phthalocyanine (ZnPc) nanowires...Hong, M.; Son, M.; Choi, H. C.* “Crystal Plane-Dependent Photoluminescence Activity of Pentacene 1D Wire and 2D Disk Crystals.” Angew. Chem. Int...Ed. 2013, 52, 5997-6001. [7] Park, J. E.; Hong, M.; Son, M.; Choi, H. C.* “Crystal Plane-Dependent Photoluminescence Activity of Pentacene 1D Wire

Design Principles and Guidelines for Security

DTIC Science & Technology

2007-11-21

Padula , Secure Computer Systems: Unified Exposition and Multics Interpretation. Electronic Systems Division, USAF. ESD-TR-75-306, MTR-2997 Rev.1...Hanscom AFB, MA. March 1976 [7] David Elliott Bell. “Looking Back at the Bell-La Padula Model,” Proc. Annual Computer Security Applications Conference

SAS FORMATS: USES AND ABUSES

EPA Science Inventory

SAS formats are a very powerful tool. They allow you to display the data in a more readable manner without modifying it. Formats can also be used to group data into categories for use in various procedures like PROC FREQ, PROC TTEST, and PROC MEANS (as a class variable). As w...

Effect of high-intensity interval exercise on lipid oxidation during postexercise recovery.

PubMed

Malatesta, Davide; Werlen, Catherine; Bulfaro, Stefano; Chenevière, Xavier; Borrani, Fabio

2009-02-01

The aim of this study was to examine whether lipid oxidation predominates during 3 h of postexercise recovery in high-intensity interval exercise as compared with moderate-intensity continuous exercise on a cycle ergometer in fit young men (n = 12; 24.6 +/- 0.6 yr). The energy substrate partitioning was evaluated during and after high-intensity submaximal interval exercise (INT, 1-min intervals at 80% of maximal aerobic power output [Wmax] with an intervening 1 min of active recovery at 40% Wmax) and 60-min moderate-intensity continuous exercise at 45% of maximal oxygen uptake (C45%) as well as a time-matched resting control trial (CON). Exercise bouts were matched for mechanical work output. During exercise, a significantly greater contribution of CHO and a lower contribution of lipid to energy expenditure were found in INT (512.7 +/- 26.6 and 41.0 +/- 14.0 kcal, respectively) than in C45% (406.3 +/- 21.2 and 170.3 +/- 24.0 kcal, respectively; P < 0.001) despite similar overall energy expenditure in both exercise trials (P = 0.13). During recovery, there were no significant differences between INT and C45% in substrate turnover and oxidation (P > 0.05). On the other hand, the mean contribution of lipids to energy yield was significantly higher after exercise trials (C45% = 61.3 +/- 4.2 kcal; INT = 66.7 +/- 4.7 kcal) than after CON (51.5 +/- 3.4 kcal; P < 0.05). These findings show that lipid oxidation during postexercise recovery was increased by a similar amount on two isoenergetic exercise bouts of different forms and intensities compared with the time-matched no-exercise control trial.

Economic burden of diabetes mellitus in the WHO African region

PubMed Central

2009-01-01

Background In 2000, the prevalence of diabetes among the 46 countries of the WHO African Region was estimated at 7.02 million people. Evidence from North America, Europe, Asia, Latin America and the Caribbean indicates that diabetes exerts a heavy health and economic burden on society. Unfortunately, there is a dearth of such evidence in the WHO African Region. The objective of this study was to estimate the economic burden associated with diabetes mellitus in the countries in the African Region. Methods Drawing information from various secondary sources, this study used standard cost-of-illness methods to estimate: (a) the direct costs, i.e. those borne by the health systems and the families in directly addressing the problem; and (b) the indirect costs, i.e. the losses in productivity attributable to premature mortality, permanent disability and temporary disability caused by the disease. Prevalence estimates of diabetes for the year 2000 were used to calculate direct and indirect costs of diabetes mellitus. A discount rate of 3% was used to convert future earnings lost into their present values. The economic burden analysis was done for three groups of countries, i.e. 6 countries whose gross national income (GNI) per capita was greater than 8000 international dollars (i.e. in purchasing power parity), 6 countries with Int$2000–7999 and 33 countries with less than Int$2000. GNI for Zimbabwe was missing. Results The 7.02 million cases of diabetes recorded by countries of the African Region in 2000 resulted in a total economic loss of Int$25.51 billion (PPP). Approximately 43.65%, 10.03% and 46.32% of that loss was incurred by groups 1, 2 and 3 countries, respectively. This translated into grand total economic loss of Int$11,431.6, Int$4,770.6 and Int$ 2,144.3 per diabetes case per year in the three groups respectively. Conclusion In spite of data limitations, the estimates reported here show that diabetes imposes a substantial economic burden on countries of the WHO African Region. That heavy burden underscores the urgent need for increased investments in the prevention and management of diabetes. PMID:19335903

Improvement of the repeatability of parallel transmission at 7T using interleaved acquisition in the calibration scan.

PubMed

Kameda, Hiroyuki; Kudo, Kohsuke; Matsuda, Tsuyoshi; Harada, Taisuke; Iwadate, Yuji; Uwano, Ikuko; Yamashita, Fumio; Yoshioka, Kunihiro; Sasaki, Makoto; Shirato, Hiroki

2017-12-04

Respiration-induced phase shift affects B 0 /B 1 + mapping repeatability in parallel transmission (pTx) calibration for 7T brain MRI, but is improved by breath-holding (BH). However, BH cannot be applied during long scans. To examine whether interleaved acquisition during calibration scanning could improve pTx repeatability and image homogeneity. Prospective. Nine healthy subjects. 7T MRI with a two-channel RF transmission system was used. Calibration scanning for B 0 /B 1 + mapping was performed under sequential acquisition/free-breathing (Seq-FB), Seq-BH, and interleaved acquisition/FB (Int-FB) conditions. The B 0 map was calculated with two echo times, and the B 1 + map was obtained using the Bloch-Siegert method. Actual flip-angle imaging (AFI) and gradient echo (GRE) imaging were performed using pTx and quadrature-Tx (qTx). All scans were acquired in five sessions. Repeatability was evaluated using intersession standard deviation (SD) or coefficient of variance (CV), and in-plane homogeneity was evaluated using in-plane CV. A paired t-test with Bonferroni correction for multiple comparisons was used. The intersession CV/SDs for the B 0 /B 1 + maps were significantly smaller in Int-FB than in Seq-FB (Bonferroni-corrected P < 0.05 for all). The intersession CVs for the AFI and GRE images were also significantly smaller in Int-FB, Seq-BH, and qTx than in Seq-FB (Bonferroni-corrected P < 0.05 for all). The in-plane CVs for the AFI and GRE images in Seq-FB, Int-FB, and Seq-BH were significantly smaller than in qTx (Bonferroni-corrected P < 0.01 for all). Using interleaved acquisition during calibration scans of pTx for 7T brain MRI improved the repeatability of B 0 /B 1 + mapping, AFI, and GRE images, without BH. 1 Technical Efficacy Stage 1 J. Magn. Reson. Imaging 2017. © 2017 International Society for Magnetic Resonance in Medicine.

Assessing climate change over the Marche Region (central Italy) from 1961 to 2100: projected changes in mean and severe precipitation (with a statistical evaluation of RCMs local performance).

NASA Astrophysics Data System (ADS)

Sangelantoni, Lorenzo; Coluccelli, Alessandro; Russo, Aniello

2014-05-01

Considering the 21st century projected precipitation over the Mediterranean basin, Marche region (central Italy, facing the Adriatic Sea) climate represents an interesting case of study, being located on a transition area between positive and negative change sign. Multi-model projections of daily mean precipitation over Marche region, have been extracted from the outputs of a set of 7 Regional Climate Models (RCMs) over Europe run by several research Institutes participating to the EU ENSEMBLE project. These climate simulations from 1961 to 2100 refer to the boundary conditions of the IPCC A1B emission scenario, with a horizontal resolution of 25km × 25km. Furthermore, two RCMs outputs from Med-CORDEX project, with a higher horizontal resolution (12km x 12km) and boundary conditions provided by the new Representative Concentration Pathway (RCP) 4.5 and 8.5, are analyzed. Observed daily mean precipitation over Marche region domain have been extracted from E-OBS gridded data set (Version 9.0) covering the period 1970-2004. Concise statistical summary of how well employed RCMs reproduce past observed Marche region precipitation (1970-2004) in term of correlation, root-mean-square difference, and the ratio of variances are graphically displayed on 2D-Taylor diagram. This multi-statistical model performance evaluation easily allows: - to compare the agreement with observation of the 9 individual RCMs - to compare RCMs with different horizontal resolution (12 km and 25 km) - to evaluate the improvement provided by the RCMs ensemble. Results indicate that the best performance is obtained by the 9 RCMs ensemble. Differently than temperature (not shown), RCMs showed a lower capability in reproducing observed mean interannual precipitation distribution, and the increase in RCMs horizontal resolution (from 25 km to 12 km) did not provide evident performance improvements. Considering that alteration in hydrologic cycle is one of the most worrying climate change outcomes at regional/local level, we brought out the hydro-climatic intensity index (HY-INT; Giorgi et al. 2011) for the Marche region. HY-INT integrates metrics of mean annual precipitation intensity and dry spell length, viewing the response of this two metrics to global warming as deeply interconnected. HY-INT shows an overall statistically significant increase (especially of dry spell length), more relevant after 2050. Taking cue from HY-INT index results, we investigated not only projected changes of mean precipitation, but also the key aspect of modification of extreme tails of the precipitation distribution. Projected percentage changes in mean and 90th percentile precipitation by comparison between 2071-2100 and 1961-1990 time slice values over Marche region were obtained. Results show two remarkable aspects linked with large scale circulation (northward shift of storm track) and thermodynamic processes (Clausius-Clapeyron relation): • summer with heavily negative anomaly in mean precipitation amount followed by spring, respectively -30% and -25%. Cold semester shows trivial decrease (about -5%, mainly on western mountainous area); • contrasting with the mean precipitation anomaly, an increase in severe precipitation events (90th percentile) is projected, especially in autumn (+25%). Future research step will be devoted to investigate regional hydrological climate change impacts, involving multi climate bias corrected variables from RCMs in combination with hydrological models.

Ideal Theory in Semigroups Based on Intersectional Soft Sets

PubMed Central

Song, Seok Zun; Jun, Young Bae

2014-01-01

The notions of int-soft semigroups and int-soft left (resp., right) ideals are introduced, and several properties are investigated. Using these notions and the notion of inclusive set, characterizations of subsemigroups and left (resp., right) ideals are considered. Using the notion of int-soft products, characterizations of int-soft semigroups and int-soft left (resp., right) ideals are discussed. We prove that the soft intersection of int-soft left (resp., right) ideals (resp., int-soft semigroups) is also int-soft left (resp., right) ideals (resp., int-soft semigroups). The concept of int-soft quasi-ideals is also introduced, and characterization of a regular semigroup is discussed. PMID:25101310

dni_slope_filter_2

Science.gov Websites

"GRIDCODE" true true false 19 Double 10 18 ,First,#,int_60,GRIDCODE,-1,-1,int_59,GRIDCODE,-1 ; true true false 19 Double 10 18 ,First,#,int_60,AVE_DNI,-1,-1,int_59,AVE_DNI,-1,-1,int_58,AVE_DNI,-1,-1 ,int_02,AVE_DNI,-1,-1,int_01,AVE_DNI,-1,-1,int_00,AVE_DNI,-1,-1;AVE_GHI "AVE_GHI" true true

dni_slope_filter_4

Science.gov Websites

"GRIDCODE" true true false 19 Double 10 18 ,First,#,int_60,GRIDCODE,-1,-1,int_59,GRIDCODE,-1 ; true true false 19 Double 10 18 ,First,#,int_60,AVE_DNI,-1,-1,int_59,AVE_DNI,-1,-1,int_58,AVE_DNI,-1,-1 ,int_02,AVE_DNI,-1,-1,int_01,AVE_DNI,-1,-1,int_00,AVE_DNI,-1,-1;AVE_GHI "AVE_GHI" true true

dni_slope_filter_5

Science.gov Websites

"GRIDCODE" true true false 19 Double 10 18 ,First,#,int_60,GRIDCODE,-1,-1,int_59,GRIDCODE,-1 ; true true false 19 Double 10 18 ,First,#,int_60,AVE_DNI,-1,-1,int_59,AVE_DNI,-1,-1,int_58,AVE_DNI,-1,-1 ,int_02,AVE_DNI,-1,-1,int_01,AVE_DNI,-1,-1,int_00,AVE_DNI,-1,-1;AVE_GHI "AVE_GHI" true true

dni_slope_filter_1

Science.gov Websites

"GRIDCODE" true true false 19 Double 10 18 ,First,#,int_60,GRIDCODE,-1,-1,int_59,GRIDCODE,-1 ; true true false 19 Double 10 18 ,First,#,int_60,AVE_DNI,-1,-1,int_59,AVE_DNI,-1,-1,int_58,AVE_DNI,-1,-1 ,int_02,AVE_DNI,-1,-1,int_01,AVE_DNI,-1,-1,int_00,AVE_DNI,-1,-1;AVE_GHI "AVE_GHI" true true

dni_slope_filter_3

Science.gov Websites

"GRIDCODE" true true false 19 Double 10 18 ,First,#,int_60,GRIDCODE,-1,-1,int_59,GRIDCODE,-1 ; true true false 19 Double 10 18 ,First,#,int_60,AVE_DNI,-1,-1,int_59,AVE_DNI,-1,-1,int_58,AVE_DNI,-1,-1 ,int_02,AVE_DNI,-1,-1,int_01,AVE_DNI,-1,-1,int_00,AVE_DNI,-1,-1;AVE_GHI "AVE_GHI" true true

A Price To Pay for Relaxed Substrate Specificity: A Comparative Kinetic Analysis of the Class II Lanthipeptide Synthetases ProcM and HalM2

PubMed Central

2015-01-01

Lanthipeptides are a class of ribosomally synthesized and posttranslationally modified peptide natural products (RiPPs) that typically harbor multiple intramolecular thioether linkages. For class II lanthipeptides, these cross-links are installed in a multistep reaction pathway by a single enzyme (LanM). The multifunctional nature of LanMs and the manipulability of their genetically encoded peptide substrates (LanAs) make LanM/LanA systems promising targets for the engineering of new antibacterial compounds. Here, we report the development of a semiquantitative mass spectrometry-based assay for kinetic characterization of LanM-catalyzed reactions. The assay was used to conduct a comparative kinetic analysis of two LanM enzymes (HalM2 and ProcM) that exhibit drastically different substrate selectivity. Numerical simulation of the kinetic data was used to develop models for the multistep HalM2- and ProcM-catalyzed reactions. These models illustrate that HalM2 and ProcM have markedly different catalytic efficiencies for the various reactions they catalyze. HalM2, which is responsible for the biosynthesis of a single compound (the Halβ subunit of the lantibiotic haloduracin), catalyzes reactions with higher catalytic efficiency than ProcM, which modifies 29 different ProcA precursor peptides during prochlorosin biosynthesis. In particular, the rates of thioether ring formation are drastically reduced in ProcM, likely because this enzyme is charged with installing a variety of lanthipeptide ring architectures in its prochlorosin products. Thus, ProcM appears to pay a kinetic price for its relaxed substrate specificity. In addition, our kinetic models suggest that conformational sampling of the LanM/LanA Michaelis complex could play an important role in the kinetics of LanA maturation. PMID:25409537

An Implementation in Pascal: Translation of Prolog into Pascal.

DTIC Science & Technology

1985-06-01

for i:=1 to px do begin ifr (proc .i..relativity=O) then continue; if proc .. ) .ptype=6) hen continue;if (proc (...abegin<>O) then continue; passname...forj:=reitorn do if (j0) then continue; if (par (.>) ppe <>1) then continue; if (par .. .namie<>par(.i.).name) parle nO ype:par C.’ ntype; par Inblnd

Evaluation of canine red blood cell quality after processing with an automated cell salvage device.

PubMed

Hofbauer, Nina; Windberger, Ursula; Schwendenwein, Ilse; Tichy, Alexander; Eberspächer, Eva

2016-05-01

To evaluate the properties of RBC concentrate harvested after processing fresh whole blood units from healthy dogs with an automated cell salvage device. Prospective, in vitro, experimental study. University teaching hospital. Sixteen healthy, privately owned dogs of various breeds. Fresh canine whole blood collected in bags with citrate phosphate dextrose adenine solution was processed with an automated cell salvage device and analyzed in vitro. Laboratory values determined before (baseline, from a catheter sample) and after processing RBCs (procRBCs) included a complete blood count, selected blood chemistry analytes, erythrocyte osmotic resistance, whole blood viscosity, RBC aggregation, and RBC deformability. Total recovery of RBCs was 80% ± 12%. Hematocrit of the procRBCs yielded by the device was 77% ± 3.7% (mean ± standard deviation). Gross morphology of the RBCs remained unchanged. The mean corpuscular volume, erythrocyte osmotic resistance, RBC deformability, RBC aggregation, and the activity of lactate dehydrogenase showed minor but statistically significant changes from baseline. No differences in the concentrations of free hemoglobin were observed. Whole blood viscosity was less in the procRBCs. Seventy-seven percent (mean) of the platelets were washed out, while a mean of 57% of the leukocytes remained in the procRBCs. Although processing canine blood with this automated cell salvage device leads to slight changes in some properties of RBCs, most of these changes are comparable to changes seen in human blood after processing. Present data indicate that the use of this cell salvage device does not induce changes in canine RBC concentrate that would preclude its use for transfusion. © Veterinary Emergency and Critical Care Society 2016.

Nurse-coordinated multidisciplinary, family-based cardiovascular disease prevention programme (EUROACTION) for patients with coronary heart disease and asymptomatic individuals at high risk of cardiovascular disease: a paired, cluster-randomised controlled trial.

PubMed

Wood, D A; Kotseva, K; Connolly, S; Jennings, C; Mead, A; Jones, J; Holden, A; De Bacquer, D; Collier, T; De Backer, G; Faergeman, O

2008-06-14

Our aim was to investigate whether a nurse-coordinated multidisciplinary, family-based preventive cardiology programme could improve standards of preventive care in routine clinical practice. In a matched, cluster-randomised, controlled trial in eight European countries, six pairs of hospitals and six pairs of general practices were assigned to an intervention programme (INT) or usual care (UC) for patients with coronary heart disease or those at high risk of developing cardiovascular disease. The primary endpoints-measured at 1 year-were family-based lifestyle change; management of blood pressure, lipids, and blood glucose to target concentrations; and prescription of cardioprotective drugs. Analysis was by intention to treat. The trial is registered as ISRCTN 71715857. 1589 and 1499 patients with coronary heart disease in hospitals and 1189 and 1128 at high risk were assigned to INT and UC, respectively. In patients with coronary heart disease who smoked in the month before the event, 136 (58%) in the INT and 154 (47%) in the UC groups did not smoke 1 year afterwards (difference in change 10.4%, 95% CI -0.3 to 21.2, p=0.06). Reduced consumption of saturated fat (196 [55%] vs 168 [40%]; 17.3%, 6.4 to 28.2, p=0.009), and increased consumption of fruit and vegetables (680 [72%] vs 349 [35%]; 37.3%, 18.1 to 56.5, p=0.004), and oily fish (156 [17%] vs 81 [8%]; 8.9%, 0.3 to 17.5, p=0.04) at 1 year were greatest in the INT group. High-risk individuals and partners showed changes only for fruit and vegetables (p=0.005). Blood-pressure target of less than 140/90 mm Hg was attained by both coronary (615 [65%] vs 547 [55%]; 10.4%, 0.6 to 20.2, p=0.04) and high-risk (586 [58%] vs 407 [41%]; 16.9%, 2.0 to 31.8, p=0.03) patients in the INT groups. Achievement of total cholesterol of less than 5 mmol/L did not differ between groups, but in high-risk patients the difference in change from baseline to 1 year was 12.7% (2.4 to 23.0, p=0.02) in favour of INT. In the hospital group, prescriptions for statins were higher in the INT group (810 [86%] vs 794 [80%]; 6.0%, -0.5 to 11.5, p=0.04). In general practices in the intervention groups, angiotensin-converting enzyme inhibitors (297 [29%] INT vs 196 [20%] UC; 8.5%, 1.8 to 15.2, p=0.02) and statins (381 [37%] INT vs 232 [22%] UC; 14.6%, 2.5 to 26.7, p=0.03) were more frequently prescribed. To achieve the potential for cardiovascular prevention, we need local preventive cardiology programmes adapted to individual countries, which are accessible by all hospitals and general practices caring for coronary and high-risk patients.

Towards a TWSTFT network time transfer

NASA Astrophysics Data System (ADS)

Jiang, Z.

2008-12-01

TWSTFT (Two Way Satellite Time and Frequency Transfer, TW hereafter) is a major technique used in TAI (International Atomic Time) generation. More than two-thirds of TAI clocks and almost all the primary frequency standards are transferred using TW. Up to now, the only geometry in TAI time transfer is single-link. However, the TAI TW time transfer data are highly redundant. In general, for an N-point network, there are N(N - 1)/2 independently measured links. Among them, only N - 1 will be used. We then have (N2 - 3N + 2)/2 redundant links. As a function of N, the redundant measurements increase quickly (cf figure 1 and table 1). At present, for the European-American network N = 13, but only 12 out of a total of 78 measured links are used in TAI. For the Asia-Pacific regions, N = 8. Full use of the high redundancy is an effective way to improve TAI without new cost. The sum of three TW links that form a closed triangle is the triangle closure. Theoretically a closure is expected to be zero if there are no measurement errors, namely the triangle closure condition. A non-zero closure is a true error and an index of the time link quality. A redundant link sets a geometric constraint. There are (N2 - 3N + 2)/2 independent conditions in a network. In 2006, Jiang and Petit (Proc. EFTF 2006 pp 468-75) proposed a mathematical model to adjust the closures to zero by global network processing. In consequence, time transfer between any two points through any link(s) in the network gives exactly the same result with the same uncertainty. This is the so-called network time transfer. In this paper, the author introduces his recent works on completing the network model by adding the calibration, the uncertainty estimation and the quality assessment using GPS PPP (time transfer by precise point positioning (PPP hereafter)) (Kouba and Héroux 2001 GPS Solut. 5 12-28, Ray and Senior 2005 Metrologia 42 215-32, Orgiazzi et al 2005 Proc. IEEE FCS 2005 pp 337-45, Defraigne et al 2007 Proc. EFTF 2007 pp 909-13, Petit and Jiang 2008 Int. J. Navig. Obs. 2008 1-8). As an independent technique with higher short-term stability, PPP is then a good reference to evaluate the improvement in the network time transfer. The gain is at least 30%. The new method also gives a solution for the high redundancy in the TAI international TW time transfer network. The TAI software Tsoft is operational to perform the network time transfer.

[Radiotherapy of squamous cell carcinomas of the tongue--a statistical review].

PubMed

Kubo, K; Furukawa, S; Fuchihata, H; Nakamura, M; Shimizutani, K; Nishiyama, K; Ikeda, H; Masaki, N

1989-01-01

The cases of 36 patients referred for radiotherapy of the tongue after an excisional biopsy or after an inadequate excision of the tongue cancer have been reviewed. In 32 patients treated by radiotherapy, the actuarial survival rate at five years was 86%, and the local rate control, was 82%. The local control rate for those treated by interstitial radiotherapy (Int. RT) was successful in 12 out of 13 cases, and the rates for those treated by external radiotherapy (Ext. RT) followed by Int. RT, or by the intraoral cone technique with electron beams (Elec.), or by Ext. RT, or by Elec. followed by Int. RT, or by no additional therapy were 7 out of 9, 4 out of 5, 2 out of 4, 1 out of 1, and 2 out of 4, respectively. For such cases of cancer, subsequent interstitial radiotherapy is advisable to maintain local control.

Imaging of Stellar Surfaces with the Navy Precision Optical Interferometer

DTIC Science & Technology

2015-09-18

geostationary satel- lite with the Navy Prototype Optical Interferome- ter,” in Proc. Optical and Infrared Interferometry II, W. C. Danchi, F...Cormier, “Imag- ing of geostationary satellites with the MRO inter- ferometer,” in Proc. Advanced Maui Optical and Space Surveillance Technologies... geostationary satellites: Signal-to-noise considerations,” in Proc. Advanced Maui Optical and Space Surveillance Technologies Conference, 2011. 6. D

78 FR 69407 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-19

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice...--RS117 SPS-RCEC Op Proc 1 to be effective 11/ 4/2013. Filed Date: 11/6/13. Accession Number: 20131106... of Eldorado Co-Tenancy and Communication Agreement to be effective 1/1/2014. Filed Date: 11/7/13...

Early Detection of Breast Cancer Using Posttranslationally Modified Biomarkers

DTIC Science & Technology

2011-03-01

1 and 2 in Globo H synthesis , Proc Natl Acad Sci U S A 105, 11667-11672. 18. Gilewski, T., Ragupathi, G., Bhuta, S., Williams, L. J., Musselli, C...carmustine and new proline analog of nitrosourea on antioxidant system in breast carcinoma cells (MCF-7), Drug Chem Toxicol 33, 55-63. 34. Galijasevic, S

Fundamental Issues in Space Electronics Reliability: Negative Bias Temperature Instability

DTIC Science & Technology

2010-12-01

Mintarno, S. Mitra, S. Krishnan, Y. Cao, “Circuit Aging Prediction for Low-Power Operation,” Proc. IEEE/CICC (2009) [7] D. A Neaman , Semiconductor Physics...dielectric based field effect transistors,” J. Appl. Phys. 104 124109 (2008) [6] D. A Neaman , Semiconductor Physics and Devices, NY: McGraw Hill

Brain and Surface Warping via Minimizing Lipschitz Extensions (PREPRINT)

DTIC Science & Technology

2006-01-01

Angenent, S. Haker , A. Tannenbaum, and R. Kikinis, “Conformal geometry and brain flattening,” Proc. MICCAI, pp. 271-278, 1999. 1 [2] G. Aronsson, M...surface mapping,” IEEE Transactions on Medical Imaging, 23:7, 2004. 1 [17] S. Haker , L. Zhu, A. Tannenbaum, and S. An- genent, “Optimal mass transport for

FUTURE PERSPECTIVES IN MELANOMA RESEARCH. Meeting report from the “Melanoma Research: a bridge from Naples to the World. Napoli, December 5th–6 th2011”

PubMed Central

2012-01-01

After more than 30 years, landmark progress has been made in the treatment of cancer, and melanoma in particular, with the success of new molecules such as ipilimumab, vemurafenib and active specific immunization. After the first congress in December 2010, the second edition of “Melanoma Research: a bridge from Naples to the World” meeting, organized by Paolo A. Ascierto (INT, Naples, Italy), Francesco M. Marincola (NIH, Bethesda, USA), and Nicola Mozzillo (INT, Naples, Italy) took place in Naples, on 5–6 December 2011. We have identified four new topics of discussion: Innovative Approaches in Prevention, Diagnosis and Surgical Treatment, New Pathways and Targets in Melanoma: An Update about Immunotherapy, and Combination Strategies. This international congress gathered more than 30 international faculty members and was focused on recent advances in melanoma molecular biology, immunology and therapy, and created an interactive atmosphere which stimulated discussion of new approaches and strategies in the field of melanoma. PMID:22551296

Sismologie Jovienne

NASA Astrophysics Data System (ADS)

Mosser, Benoît

2000-01-01

Dis-moi comment tu oscilles, je te dirai qui tu es... La Terre, le Soleil ont bien voulu répondre à cette question, et leurs intérieurs sont pour une large part dévoilés. Etoiles et planètes subissent actuellement un interrogatoire serré. Ce mémoire de thèse d'habilitation expose l'état des recherches concernant l'étude sismique de Jupiter, menées essentiellement par la communauté astrophysique française. Il s'attache à montrer tout ce que l'étude sismique de Jupiter, et elle-seule, peut dévoiler. Les principaux résultats sont rappelés, et surtout les conditions dans lesquelles ils ont été obtenus: les fréquences caractéristiques de Jupiter et Procyon ont été mesurées, avec un degré de confiance élevé. Un point observationnel est plus particulièrement développé: la sismométrie jovienne et stellaire avec le spectromètre par transformée de Fourier (FTS) du CFH. Cet instrument unique, que d'aucuns aimeraient reléguer dans un musée, s'est révélé excellent sismomètre et s'avère a court terme comme le seul outil disponible pour l'étude sismique de Jupiter, avec des performances encore améliorées. Il a permis d'acquérir une expertise unique sur laquelle se basent les recherches observationnelles à poursuivre. Les acquis théoriques et observationnels de la sismologie jovienne permettent de dégager les priorités à moyen et long terme: les développements théoriques nécessaires pour répondre aux questions posées par la modélisation de l'intérieur jovien, et surtout les développements intrumentaux sans lesquels le sujet n'a pas d'avenir. On-line Thesis, Benoît Mosser

Wavelength Independent Optical Lithography.

DTIC Science & Technology

1986-06-06

lamp because it has a smooth, broadband output in the visible and near UV. High Density Optical Intormation Storage The NSOM concept can be combined...stringent control can be maintained over the temperature of the entire apparatus. Ideally, both of these methods should be used. - . * S P. .~ V: -:V- TwT ...DNA helixes : enantiomers of tris(4, 7-diphenylpheanthroline)ruthenium (II). Proc. Natl. Acad. Sci. U.S.A. 81, 7 (1984). 27. J.M. Fernandez, E. Neher

Mechanisms of Cytotoxicity of the Aids Virus

DTIC Science & Technology

1994-08-01

al., 1987; Luciw et al., 1989), sheep (visna virus) (Haas et al., 1985), goats (caprine-arthritis encepha- litis virus) (Narayan & Cork , 1985), and...into therapeutic maneuvers which may suppress virus replication and/or cytopathicity, and assist in the development of a vaccine for WIV prevention. 7...and AIDS. Narayan and Cork , 1985, Rev. Infect. Dis. 7:89. Niederran et al., 1989, Proc. Natl. Acad. Sci. 86:1128. Pederson et al., 1987, Science 235

Modeling MultiCoil ICPs

NASA Astrophysics Data System (ADS)

Kolobov, V. I.; Vaidya, N.; Krishnan, A.

1998-10-01

Plasma processing of 300 mm wafers and flat panels places stringent demands on plasma uniformity across large surfaces. A natural solution towards an uniform plasma in a minimum discharge volume is to maintain the plasma by an array of individual sources. Although the design of the individual sources can differ considerably, there is a common feature for all such devices which have been recently suggested by several groups: their essentially 3D geometry. Engineering design of these devices is a challenging task and computational modeling could be a very useful tool. CFD Research Corp. has developed a comprehensive software for virtual prototyping of ICP sources designed for complex 3D geometries with unstructured solution-adaptive mesh. In this paper we shall present the results of our simulation of the multipole high density source [1] which is an example of MultiCoil ICP. We shall describe the procedure of solving the electromagnetic part of the problem using magnetic vector potential and analyse design issues such as the size of dielectric windows. We shall present results of parametric studies of the source for different geometries, gas pressures and plasma densities for simple argon chemistry. [1] J.Ogle. Proc. VI Int. Workshop on Advanced Plasma Tools and Process Engineering, pp. 85-90, May 1998, Millbrae, USA.

Quantitative Analysis of Statics and Dynamics of Actin Cables in Fission Yeast

NASA Astrophysics Data System (ADS)

Yusuf, Eddy; Wu, Jian-Qiu; Vavylonis, Dimitrios

2010-03-01

The assembly of actin and tubulin proteins into long filaments and bundles, i.e. closely-packed filaments, underlies important cellular processes such as cell motility, intracellular transport, and cell division. Recent theoretical and experimental work has addressed the nonequilibrium dynamics of single microtubules within live cells [1]. Actin filaments usually form dense networks that prevents microscopic imaging of individual filaments or bundles. Here, we studied actin dynamics using fission yeast that has low-density actin cytoskeleton consisting of actin cables (actin bundles aligned along the long axis of the cell) and ``actin patches.'' Yeast cells expressing GFP-CHD were imaged by 3D confocal microscopy. Stretching open active contours [2] were used to segment and track individual actin cables. We analyzed their curvature distribution, the tangent correlation, and the temporal bending amplitude fluctuations. We contrast our findings to equilibrium fluctuating semiflexible polymers and to microtubules in cells. We calculate the important time and length scales for the actin cables. We also discuss our findings within the broad context of understanding actin assembly in cells. [1] C. P. Brangwynne et. al., Phys. Rev. Lett. 100, 118104 (2008) [2] H. Li et. al., Proc. of the IEEE Int'l Symposium on Biomedical Imaging: From Nano to Macro, ISBI'09

The influence of maternal nutrition on expression of genes responsible for adipogenesis and myogenesis in the bovine fetus.

PubMed

Jennings, T D; Gonda, M G; Underwood, K R; Wertz-Lutz, A E; Blair, A D

2016-10-01

The objective of this study was to determine whether altered maternal energy supply during mid-gestation results in differences in muscle histology or genes regulating fetal adipose and muscle development. In total, 22 Angus cross-bred heifers (BW=527.73±8.3 kg) were assigned randomly to the three dietary treatments providing 146% (HIGH; n=7), 87% (INT; n=7) or 72% (LOW; n=8) of the energy requirements for heifers from day 85 to day 180 of gestation. Fetuses were removed via cesarean section at day 180 of gestation and longissimus muscle (LM) and subcutaneous fat were collected and prepared for analysis of gene expression. Samples from the LM and semitendinosus (ST) were evaluated for muscle fiber diameter, area and number. The right hind limb was dissected and analyzed to determine compositional analysis. Fetal growth and muscle histology characteristics of the LM and ST were similar among treatments. Preadipocyte factor-1 expression was up-regulated in fetal LM (P<0.05) of HIGH fetuses as compared with INT, whereas LOW fetuses showed increased CCAAT/enhancer-binding protein-β (C/EBP-β) expression in LM as compared with INT (P<0.05). Peroxisome proliferator-activated receptor γand C/EBP-α did not differ as a result of dietary treatment in LM or subcutaneous fat samples. There was a tendency for increased expression of fatty acid synthase in LM of LOW fetuses as compared with INT (P<0.10). Myogenin was more highly expressed (P<0.05) in LM of the LOW fetuses, whereas μ-calpain expression was increased in the HIGH treatment compared with INT. A tendency for increased expression of IGF-II was observed for both LOW and HIGH fetuses compared with INT (P<0.10). Expression of stearoyl-CoA desaturase, myoblast determination protein 1, myogenic factor 5, myogenic regulatory factor-4, m-calpain, calpastatin, IGF-I and myostatin was similar between treatments. Collectively, these results suggest that fetal growth characteristics are not affected by the level of maternal nutritional manipulation imposed in this study during mid-gestation. However, differences in expression of fetal genes regulating adipose and muscle tissue growth and development could lead to differences in postnatal composition and warrants further investigation.

A core hSSB1–INTS complex participates in the DNA damage response

PubMed Central

Zhang, Feng; Ma, Teng; Yu, Xiaochun

2013-01-01

Summary Human single-stranded DNA-binding protein 1 (hSSB1) plays an important role in the DNA damage response and the maintenance of genomic stability. It has been shown that the core hSSB1 complex contains hSSB1, INTS3 and C9orf80. Using protein affinity purification, we have identified integrator complex subunit 6 (INTS6) as a major subunit of the core hSSB1 complex. INTS6 forms a stable complex with INTS3 and hSSB1 both in vitro and in vivo. In this complex, INTS6 directly interacts with INTS3. In response to the DNA damage response, along with INTS3 and hSSB1, INTS6 relocates to the DNA damage sites. Moreover, the hSSB1–INTS complex regulates the accumulation of RAD51 and BRCA1 at DNA damage sites and the correlated homologous recombination. PMID:23986477

Challenges of anamorphic high-NA lithography and mask making

NASA Astrophysics Data System (ADS)

Hsu, Stephen D.; Liu, Jingjing

2017-06-01

Chip makers are actively working on the adoption of 0.33 numerical aperture (NA) EUV scanners for the 7-nm and 5-nm nodes (B. Turko, S. L. Carson, A. Lio, T. Liang, M. Phillips, et al., in `Proc. SPIE9776, Extreme Ultraviolet (EUV) Lithography VII', vol. 977602 (2016) doi: 10.1117/12.2225014; A. Lio, in `Proc. SPIE9776, Extreme Ultraviolet (EUV) Lithography VII', vol. 97760V (2016) doi: 10.1117/12.2225017). In the meantime, leading foundries and integrated device manufacturers are starting to investigate patterning options beyond the 5-nm node (O. Wood, S. Raghunathan, P. Mangat, V. Philipsen, V. Luong, et al., in `Proc. SPIE. 9422, Extreme Ultraviolet (EUV) Lithography VI', vol. 94220I (2015) doi: 10.1117/12.2085022). To minimize the cost and process complexity of multiple patterning beyond the 5-nm node, EUV high-NA single-exposure patterning is a preferred method over EUV double patterning (O. Wood, S. Raghunathan, P. Mangat, V. Philipsen, V. Luong, et al., in `Proc. SPIE. 9422, Extreme Ultraviolet (EUV) Lithography VI', vol. 94220I (2015) doi: 10.1117/12.2085022; J. van Schoot, K. van Ingen Schenau, G. Bottiglieri, K. Troost, J. Zimmerman, et al., `Proc. SPIE. 9776, Extreme Ultraviolet (EUV) Lithography VII', vol. 97761I (2016) doi: 10.1117/12.2220150). The EUV high-NA scanner equipped with a projection lens of 0.55 NA is designed to support resolutions below 10 nm. The high-NA system is beneficial for enhancing resolution, minimizing mask proximity correction bias, improving normalized image log slope (NILS), and controlling CD uniformity (CDU). However, increasing NA from 0.33 to 0.55 reduces the depth of focus (DOF) significantly. Therefore, the source mask optimization (SMO) with sub-resolution assist features (SRAFs) are needed to increase DOF to meet the demanding full chip process control requirements (S. Hsu, R. Howell, J. Jia, H.-Y. Liu, K. Gronlund, et al., EUV `Proc. SPIE9048, Extreme Ultraviolet (EUV) Lithography VI', (2015) doi: 10.1117/12.2086074). To ensure no assist feature printing, the assist feature sizes need to be scaled with λ/NA. The extremely small SRAF width (below 25 nm on the reticle) is difficult to fabricate across the full reticle. In this paper, we introduce an innovative `attenuated SRAF' to improve SRAF manufacturability and still maintain the process window benefit. A new mask fabrication process is proposed to use existing mask-making capability to manufacture the attenuated SRAFs. The high-NA EUV system utilizes anamorphic reduction; 4× in the horizontal (slit) direction and 8× in the vertical (scanning) direction (J. van Schoot, K. van Ingen Schenau, G. Bottiglieri, K. Troost, J. Zimmerman, et al., `Proc. SPIE. 9776, Extreme Ultraviolet (EUV) Lithography VII', vol. 97761I (2016) doi: 10.1117/12.2220150; B. Kneer, S. Migura, W. Kaiser, J. T. Neumann, J. van Schoot, in `Proc. SPIE9422, Extreme Ultraviolet (EUV) Lithography VI', vol. 94221G (2015) doi: 10.1117/12.2175488). For an anamorphic system, the magnification has an angular dependency, and thus, familiar mask specifications such as mask error factor (MEF) need to be redefined. Similarly, mask-manufacturing rule check (MRC) needs to consider feature orientation.

Impacts of parturition and body condition score on glucose uptake capacity of bovine monocyte subsets.

PubMed

Eger, Melanie; Hussen, Jamal; Drong, Caroline; Meyer, Ulrich; von Soosten, Dirk; Frahm, Jana; Daenicke, Sven; Breves, Gerhard; Schuberth, Hans-Joachim

2015-07-15

The peripartal period of dairy cows is associated with a higher incidence of infectious diseases like mastitis or metritis, particularly in high-yielding animals. The onset of lactation induces a negative energy balance and a shift of glucose distribution toward the udder. Glucose is used as primary fuel by monocytes which give rise to macrophages, key cells in the defense against pathogens. The aim of this study was to analyze whether animals with high or low body condition score (BCS) differ in composition and glucose uptake capacities of bovine monocyte subsets. Blood samples were taken from 27 dairy cows starting 42 days before parturition until day 56 after parturition. The cows were allocated to two groups according to their BCS. A feeding regime was applied, in which the BCS high group received higher amounts of concentrate before parturition and concentrate feeding was more restricted in the BCS high group after parturition compared with the BCS low group, to promote postpartal lipolysis and enhance negative energy balance in the BCS high group. Blood cell counts of classical (cM), intermediate (intM) and nonclassical monocytes (ncM) were increased at day 7 after calving. In the BCS low group intM numbers were significantly higher compared to the BCS high group at day 7 after parturition. Within the BCS low group cows suffering from mastitis or metritis showed significantly higher numbers of cM, intM and ncM at day 7 after parturition. Classical monocytes and intM showed similar glucose uptake capacities while values for ncM were significantly lower. Compared with antepartal capacities and irrespective of BCS and postpartal mastitis or metritis, glucose uptake of all monocyte subsets decreased after parturition. In conclusion, whereas glucose uptake capacity of bovine monocyte subsets is altered by parturition, it is not linked to the energy supply of the animals or to postpartal infectious diseases. Copyright © 2015 Elsevier B.V. All rights reserved.

Characterization of kidney CD45intCD11bintF4/80+MHCII+CX3CR1+Ly6C- "intermediate mononuclear phagocytic cells".

PubMed

Lee, Sul A; Noel, Sanjeev; Sadasivam, Mohanraj; Allaf, Mohamad E; Pierorazio, Phillip M; Hamad, Abdel R A; Rabb, Hamid

2018-01-01

Kidney immune cells play important roles in pathogenesis of many diseases, including ischemia-reperfusion injury (IRI) and transplant rejection. While studying murine kidney T cells, we serendipitously identified a kidney mononuclear phagocytic cell (MPC) subset characterized by intermediate surface expression of CD45 and CD11b. These CD45intCD11bint MPCs were further identified as F4/80+MHCII+CX3CR1+Ly6C- cells, comprising ~17% of total CD45+ cells in normal mouse kidney (P < 0.01) and virtually absent from all other organs examined except the heart. Systemic clodronate treatment had more significant depletive effect on the CD45intCD11bint population (77.3%±5.9%, P = 0.03) than on CD45highCD11b+ population (14.8%±16.6%, P = 0.49). In addition, CD45intCD11bint MPCs had higher phagocytic function in the normal kidney (35.6%±3.3% vs. 24.1%±2.2%, P = 0.04), but lower phagocytic capacity in post-ischemic kidney (54.9%±1.0% vs. 67.8%±1.9%, P < 0.01) compared to the CD45highCD11b+ population. Moreover, the CD45intCD11bint population had higher intracellular production of the pro-inflammatory tumor necrosis factor (TNF)-α (58.4%±5.2% vs. 27.3%±0.9%, P < 0.001) after lipopolysaccharide (LPS) stimulation and lower production of the anti-inflammatory interleukin (IL)-10 (7.2%±1.3% vs. 14.9%±2.2%, P = 0.02) following kidney IRI, suggesting a functional role under inflammatory conditions. The CD45intCD11bint cells increased early after IRI, and then abruptly decreased 48h later, whereas CD45highCD11b+ cells steadily increased after IRI before declining at 72h (P = 0.03). We also identified the CD45intCD11bint MPC subtype in human kidney. We conclude that CD45intCD11bint F4/80+MHCII+CX3CR1+Ly6C-population represent a unique subset of MPCs found in both mouse and human kidneys. Future studies will further characterize their role in kidney health and disease.

Algorithmes et architectures pour ordinateurs quantiques supraconducteurs

NASA Astrophysics Data System (ADS)

Blais, A.

2003-09-01

Algorithms and architectures for superconducting quantum computers Since its formulation, information theory was based, implicitly, on the laws of classical physics. Such a formulation is however incomplete because it does not take into account quantum reality. During the last twenty years, expansion of theory information to include quantum effects has known growing interest. The practical realization of a system for quantum data processing system, a quantum computer, presents however many challenges. In this book, we are interested in various aspects of these challenges. We start by presenting algorithmic concepts like optimization of quantum computations and geometric quantum computation. We then consider various designs and aspects of qubits based on Josephson junctions. In particular, an original approach to the interaction between superconducting qubits is presented. This approach is very general since it can be applied to various designs of qubits. Finally, we are interested in read-out of the superconductic flux qubits. The detector suggested here has the advantage that it is possible to uncouple it from the qubit when no measurement is in progress. Depuis sa formulation, la théorie de l'information a été basée, implicitement, sur les lois de la physique classique. Une telle formulation est toutefois incomplète puisqu'elle ne tient pas compte de la réalité quantique. Au cours des vingt dernières années, l'expansion de la théorie de l'information, de façon à englober les effets purement quantiques, a connu un intérêt grandissant. La réalisation d'un système de traitement de l'information quantique, un ordinateur quantique, présente toutefois de nombreux défis. Dans cet ouvrage, on s'intéresse à différents aspects concernant ces défis. On commence par présenter des concepts algorithmiques comme l'optimisation de calculs quantiques et le calcul quantique géométrique. Par la suite, on s'intéresse à différents designs et aspects de l'utilisation de qubits basés sur les jonctions Josephson. On présente entre autres une approche originale pour l'interaction entre qubits. Cette approche est très générale puisqu'elle peut être appliquée à différents designs de qubits. Finalement, on s'intéresse à la lecture des qubits supraconducteurs de flux. Le détecteur suggéré ici a l'avantage de pouvoir être découplé du qubit lorsqu'il n'y a pas de mesure en cours.

Laser-induced forward transfer for improving fine-line metallization in photovoltaic applications

NASA Astrophysics Data System (ADS)

Sanchez-Aniorte, M. I.; Mouhamadou, B.; Alloncle, A. P.; Sarnet, T.; Delaporte, P.

2016-06-01

Grand challenges to create new front metallization techniques in photovoltaic focus considerable attention on laser-induced forward transfer (LIFT) approach. This alternative method aims to overcome the limitations of the well-established and mature screen-printing (SP) technique. Such limitations are for instance restrictions in the grid pattern design, high-temperature steps, and limited aspect ratio of the line contact (Poulain et al. in Appl Surf Sci 257:5241-5244, 2011). Although different new front contact metallization concepts have been studied, most of them require a second print step to increase the volume of the contact (Gao et al. in Proceedings of 25th EU PVSEC conference, 2010; Beaucarne and Schubert in Energy Proc 67:2-12, 2015; Lossen and Matusovsky in Energy Proc 67:156-162, 2015; Green in Phys E 14:65-70, 2002; Lennon et al. in Prog Photovolt Res Appl V21:1454-1468, 2012). As a result, it is desirable to find innovative metallization techniques to improve the cell efficiency without significantly increasing the cost. Although many challenges remain before to obtain high-quality, robust, and high-performance LIFT contact formation, it required a fully theoretical and experimental assessment. This paper presents the results of a study of the LIFT technique in picosecond regime and thick silver pastes to create high-quality conductive lines for photovoltaic applications.

The role of genomics in conservation and reproductive sciences.

PubMed

Johnson, Warren E; Koepfli, Klaus

2014-01-01

Genomics, the study of an organism's genome through DNA analyses, is a central part of the biological sciences and is rapidly changing approaches to animal conservation. The genomes of thousands of organisms, including vertebrates, invertebrates, and plants have been sequenced and the results annotated, augmented and refined through the application of new approaches in transcriptomics, proteomics, and metabolomics that enhance the characterization of messenger RNA, proteins, and metabolites. The same computational advances that are catalyzing "-omic" technologies and novel approaches to address fundamental research questions are facilitating bioinformatic analysis and enabling access of primary and derivative data and results in public and private databases (Zhao and Grant. Curr Pharm Biotechnol 12:293-305, 2011). These tools will be used to provide fundamental advances in our understanding of reproductive biology across vertebrate species and promise to revolutionize our approach to conservation biology.The vulnerability of animal populations and their genetic diversity is well documented, as are the myriad of causes and threats to their persistence, including habitat degradation and loss, overexploitation, pollution, invasive alien species, and climate change. Of the 64,283 vertebrates assessed by the International Union for Conservation of Nature in their 2012 Red List of Threatened Species, 7,250 or ~11 % are threatened with extinction, a percentage that has been increasing steadily for at least the last decade ( www.iucnredlist.org ). Among many of these species, important genetic diversity has been lost, thereby increasing their vulnerability as genetically diverse populations have higher fitness, generally are more resilient to environmental challenges, and have more adaptive potential (Reed and Frankham Conserv Biol 17:230-237, 2003; Luikart et al. Nat Rev Genet 4:981-994, 2003). In turn, genetic variation within and among populations may be essential to maintaining functional ecosystems, evolutionary process and will impact future food supplies, human health, biomaterial development and geopolitics (Myers and Knoll Proc Natl Acad Sci U S A 98:5389-5392, 2001; Templeton et al. Proc Natl Acad Sci U S A 98:5426-5432, 2001). Therefore, conservation of genetic diversity is a social, cultural, scientific, and economic prerogative and is the key to adaptation in the uncertain future of a human-dominated environment. Once lost, genetic resources are nearly impossible to regain, increasing the urgency of fundamental global approaches (e.g. www.cbd.int/sp/targets ).In this chapter we provide a review of current research and recent advances in biotechnology and genomic approaches for animal conservation and the management of genetic resources, with an emphasis on reproductive sciences. It is intended to provide information and insights for research and to provoke thoughts on how to take advantage of these opportunities.

Databases in Healthcare.

DTIC Science & Technology

1980-03-01

34; Proc. ACM Pacific 75 Conference, Boole and Babbage , Palo Alto, CA., 1975. Giebin75 Giebink, G.A., et al: "Current Status of Ambulatory Health Care...13, pp. 36-49, 1978. Stimso78 Stimson, D.H. and G. Charles : "A Computer-Based Information System in an Ambulatory Care System and Case Study" Proc...Base Management Systems" Proc. ACM Pacific 75 Conference, Boole and Babbage , Palo Alto, CA, 1975. Szolov78 Szolovits, P. and S.G. Pauker: "Categorical

Peut-on améliorer la motivation des étudiants en médecine pour un cours fondamental de physiologie en intégrant à l’exposé magistral quelques méthodes pédagogiques actives?

PubMed Central

Bentata, Yassamine; Delfosse, Catherine

2017-01-01

La motivation des étudiants est une condition essentielle à l’apprentissage et la perception qu’a l’étudiant de la valeur qu’il accorde à une activité est l’une des trois composantes majeures de cette motivation. Comment amener les étudiants à percevoir l’utilité et l’intérêt de leurs cours universitaires tout en suscitant leur motivation ? L’objectif de l’étude est de déterminer la perception de la valeur attribuée par les étudiants au cours fondamental de physiologie et d’évaluer l’impact de l’intégration de quelques méthodes d’apprentissage actif aux exposés magistraux sur la motivation des étudiants du premier cycle des études médicales dans une jeune faculté. Cette étude prospective, a concerné les étudiants de deuxième année de médecine (PCEM2). Nous avons procédé initialement à une appréciation de la perception de la motivation des étudiants pour les cours universitaires via un premier questionnaire, après nous avons intégré deux activités pédagogiques: l’étude de cas et la réalisation de carte conceptuelle aux exposés magistraux du module de physiologie et à la fin nous avons évalué via un deuxième questionnaire l’impact de ces deux activités sur la motivation des étudiants. 131 et 109 étudiants ont rempli et rendu respectivement le 1er et le 2ème questionnaire parmi les 249 étudiants inscrits en PCEM2. La motivation de nos étudiants à l’égard de leurs cours universitaires était globalement très favorable, même si la motivation pour le cours de physiologie (70,8%) était légèrement moins importante que pour l’ensemble des cours (80%). Nos étudiants avaient apprécié les deux activités proposées et seulement 13% (pour l’étude de cas) et 16,8% (pour la carte) ne se montraient pas satisfaits. 40,9% des étudiants avaient réalisé une carte conceptuelle et la qualité de ces productions, jugée sur l’identification des concepts et des liens inter concepts, était globalement satisfaisante pour une première expérience. Influencée par de multiples facteurs internes et externes, la motivation des étudiants reste une grande problématique en milieu universitaire. Dans ce contexte, une planification rigoureuse d’activités pédagogiques diversifiées et actives est l’une des principales portes offertes à l’enseignant pouvant susciter cette motivation. PMID:29721145

Effects of ring castration with local anesthesia and analgesia in Holstein calves at 3 months of age on welfare indicators.

PubMed

Marti, S; Velarde, A; de la Torre, J L; Bach, A; Aris, A; Serrano, A; Manteca, X; Devant, M

2010-08-01

Forty-seven Holstein calves (130 +/- 3.43 kg of BW and 95 +/- 1.5 d of age) were randomly assigned to 2 treatments [intact (INT), n = 23; or castrated (CAS), n = 24] to evaluate the effect of ring castration at 3 mo of age on welfare indicators. Castration was performed with local anesthesia (2% lidocaine, 3 mL in each testis and 2 mL in the scrotum) and analgesia (flunixin meglumine, intramuscularly, 3 mg/kg of BW). No local anesthesia or analgesia was used with INT calves. Serum cortisol concentration was determined at -120, 0, 30, 60, 90, and 180 min with respect to castration. At d 0, 1, 3, 7, 14, 21, 28, 35, 42, and 49, serum haptoglobin concentration was determined, rectal body and scrotal temperatures were measured, lesions at the castration site were scored, and the activity and behavior of 18 calves (9 INT and 9 CAS) were recorded continuously for 24 h. Weekly BW and concentrate and straw DMI were recorded. To evaluate humoral immunity, at 14 d after castration, ovalbumin was injected subcutaneously and serum antibody titers against ovalbumin before the injection and at d 35 were determined. At d 49 after castration, calves were intravenously injected with ACTH, and at 0, 1, 2, and 4 h thereafter, serum cortisol and testosterone concentrations were determined. Average daily gain was greater (P < 0.001) in INT than CAS calves (1.36 vs. 1.16 +/- 0.038 kg/d, respectively). Area under the curve of cortisol at castration day was reduced (P < 0.05) in CAS calves compared with INT calves (18 vs. 33 +/- 5.2 nmol/L per hour, respectively). The main scrotal lesion score observed in CAS calves throughout the study was 0, corresponding to no visible swelling, inflammation, or infection. However, scrotal lesion scores classified as 1 (swelling) were greater (P < 0.01) at 21 and 28 d after castration than at 1, 3, 7, and 14 d. Abnormal standing occurred more frequently (P < 0.001) in CAS than INT calves (2.6 vs. 0.5 +/- 0.03%, respectively) from 3 to 14 d after castration. Head turning tended (P = 0.06) to be greater at d 14 of the study in CAS than INT calves (3.0 vs. 2.6 +/- 0.04%, respectively). At d 49, 100% of CAS calves had no testes and no serum testosterone was detected. In summary, ring castration of Holstein calves performed at 3 mo of age with local anesthesia and analgesia decreased ADG and affected some behavioral traits during the first 14 d after castration. However, intake, serum cortisol and haptoglobin concentrations, rectal temperature, and humoral immunity were not altered.

3 CFR 8735 - Proclamation 8735 of October 7, 2011. Columbus Day, 2011

Code of Federal Regulations, 2012 CFR

2012-01-01

... Proc. 8735 Columbus Day, 2011By the President of the United States of America A Proclamation On October... generations reach new horizons. Ten weeks before his arrival in the Americas, Columbus and his crewmembers set... that continue to enrich the fabric of American life. Columbus returned to the Americas three more times...

Cooperative Interactions During Human Mammary Epithelial Cell Immortalization

DTIC Science & Technology

2005-07-01

papilloma virus 16 E6 or E7. Proc. Nat. Acad. Sci. USA, 92: 3687-3691, 1995. 6. Huschtscha, L. I., Neumann, A. A., Noble, J. R., and Reddel, R. R. Effects...Oncology, In press. 5. Wazer, D. E., Liu, X.-L., Chu, Q., Gao, Q., and Band, V. Immortalization of distinct human mammary epithelial cell types by human

Expression of truncated Int6/eIF3e in mammary alveolar epithelium leads to persistent hyperplasia and tumorigenesis

PubMed Central

Mack, David L; Boulanger, Corinne A; Callahan, Robert; Smith, Gilbert H

2007-01-01

Introduction Int6 has been shown to be an interactive participant with the protein translation initiation complex eIF3, the COP9 signalosome and the regulatory lid of the 26S proteasome. Insertion of mouse mammary tumor virus into the Int6 locus creates a C-terminally truncated form of the protein. Expression of the truncated form of Int6 (Int6sh) in stably transfected human and mouse mammary epithelial cell lines leads to cellular transformation. In addition, decreased expression of Int6/eIF3e is observed in approximately one third of all human breast carcinomas. Methods To validate that Int6sh has transforming activity in vivo, a transgenic mouse model was designed using the whey acidic protein (Wap) promoter to target expression of truncated Int6 to differentiating alveolar epithelial cells in the mammary gland. Microarray analyses were performed on normal, premalignant and malignant WapInt6sh expressing tissues. Results Mammary tumors developed in 42% of WapInt6sh heterozygous parous females at an average age of 18 months. In WapInt6sh mice, the contralateral mammary glands from both tumorous and non-tumorous tissues contained widespread focal alveolar hyperplasia. Only 4% of WapInt6sh non-breeding females developed tumors by 2 years of age. The Wap promoter is active only during estrus in the mammary tissue of cycling non-pregnant mice. Microarray analyses of mammary tissues demonstrated that Int6sh expression in the alveolar tissue altered the mammary transcriptome in a specific manner that was detectable even in the first pregnancy. This Int6sh-specific transcriptome pattern subsequently persisted in both the Int6sh-expressing alveolar hyperplasia and mammary tumors. These observations are consistent with the conclusion that WapInt6sh-expressing alveolar cells survive involution following the cessation of lactation, and subsequently give rise to the mammary tumors that arise in aging multiparous females. Conclusion These observations provide direct in vivo evidence that mammary-specific expression of the Int6sh truncation leads to persistence of alveolar hyperplasia with the accompanying increased predisposition to mammary tumorigenesis. PMID:17626637

Angiotensin converting enzyme 2 polymorphisms and postexercise hypotension in hypertensive medicated individuals.

PubMed

Goessler, Karla F; Polito, Marcos D; Mota, Gloria de F; de Oliveira, Edilamar M; Cornelissen, Véronique A

2018-03-01

The renin-angiotensin aldosterone system (RAAS) is associated with diverse physiological responses and adaptations to exercise. The angiotensin converting enzyme (ACE) 2 has vasodilatory effects, which might be associated with the blood pressure (BP) responses to acute exercise. The aim of this study was to investigate the role of ACE2 polymorphisms in postexercise hypotension (PEH). Thirty-four medicated hypertensive (61·3 ± 1·7 years, 76·1 ± 2·7 kg, 160 ± 1·6 cm) men (n = 12) and women (n = 22), participated in a control and a moderate intensity exercise session in a randomized order. After both experimental sessions, they left the laboratory wearing an ambulatory BP device for 24-h monitoring. ACE2 polymorphisms (Int-1 and Int-3) were assessed by polymerase chain reaction. Over the course of 5-h monitoring, we observed a significant reduction in SBP and DBP following exercise in the AA/AG of the Int-1 polymorphism (p-interaction = 0·02 and 0·001, respectively), whereas this could not be found in the individuals homozygous G (p-interaction = 0·76 and 0·51, respectively). With regard to Int-3 polymorphism, individuals AA/AG showed a significant reduction in SBP following exercise (p-interaction <0·0001) but not for DBP (p-interaction = 0·06) whereas GG individuals showed only a significant reduction in DBP following exercise (p-interaction = 0·02). Our results suggest that ACE2 polymorphism could affect PEH; however, larger trials are needed to confirm our findings. © 2016 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Published by John Wiley & Sons Ltd.

The monetary value of human lives lost due to neglected tropical diseases in Africa.

PubMed

Kirigia, Joses Muthuri; Mburugu, Gitonga N

2017-12-18

Neglected tropical diseases (NTDs) are an important cause of death and disability in Africa. This study estimates the monetary value of human lives lost due to NTDs in the continent in 2015. The lost output or human capital approach was used to evaluate the years of life lost due to premature deaths from NTDs among 10 high/upper-middle-income (Group 1), 17 middle-income (Group 2) and 27 low-income (Group 3) countries in Africa. The future losses were discounted to their present values at a 3% discount rate. The model was re-analysed using 5% and 10% discount rates to assess the impact on the estimated total value of human lives lost. The estimated value of 67 860 human lives lost in 2015 due to NTDs was Int$ 5 112 472 607. Out of that, 14.6% was borne by Group 1, 57.7% by Group 2 and 27.7% by Group 3 countries. The mean value of human life lost per NTD death was Int$ 231 278, Int$ 109 771 and Int$ 37 489 for Group 1, Group 2 and Group 3 countries, respectively. The estimated value of human lives lost in 2015 due to NTDs was equivalent to 0.1% of the cumulative gross domestic product of the 53 continental African countries. Even though NTDs are not a major cause of death, they impact negatively on the productivity of those affected throughout their life-course. Thus, the case for investing in NTDs control should also be influenced by the value of NTD morbidity, availability of effective donated medicines, human rights arguments, and need to achieve the NTD-related target 3.3 of the United Nations Sustainable Development Goal 3 (on health) by 2030.

Measurement of the Lamb shift in the hydrogen atom (n = 2)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sokolov, Y.L.; Yakovlev, V.P.

1982-07-01

A principle is proposed for the observation of the stationary interference pattern of two phase-shifted components of the 2p (or 2s) state of the hydrogen atom (Yu. L. Sokolov, Sov. Phys. JETP 36, 243 (1973)); (Proc. 6-th Internat. Conf. on Atomic Phys., Riga, 1978, p. 207). An atomic interferometer, a device analogous in principle to a two-channel optical (such as Michelson's) interferometer, is used to measure the frequency of the (2s/sub 1/2/, F = 0)--(2p/sub 1/2/, F = 0) transition in the hydrogen atom, which is found to equal 909.9014 +- 0.0019 MHz. The corresponding Lamb shift is delta(H, nmore » = 2) = 1057.8594 +- 0.0019 MHz.« less

Department of Defense Congressional Action on FY 1984 Authorization Request.

DTIC Science & Technology

1983-10-11

AUTHORIZATION NOTE: The Military Construction Bill authorization recommendation totaIS dIO not include projects authorized using savings or authorized for...change from the request). &DE9rooi)00 ti M S in Million (Zallocki- Proc. of Ammunition. Armsy Nerve gas artillery shells .185 Bethune) Proc. of...Ammunitioin. Army Nerve gas production -96S (Gore) Missile Proc, Air Force MX Production funds -357 8 (Byron) ROTE, Air Force T-46A Trainer Aircraft . 200

Occurrences and Characterization of Antibiotic-Resistant Bacteria and Genetic Determinants of Hospital Wastewater in a Tropical Country.

PubMed

Le, Thai-Hoang; Ng, Charmaine; Chen, Hongjie; Yi, Xin Zhu; Koh, Tse Hsien; Barkham, Timothy Mark Sebastian; Zhou, Zhi; Gin, Karina Yew-Hoong

2016-12-01

Wastewater discharged from clinical isolation and general wards at two hospitals in Singapore was examined to determine the emerging trends of antibiotic resistance (AR). We quantified the concentrations of 12 antibiotic compounds by analysis using liquid chromatography-tandem mass spectrometry (LC-MS/MS), antibiotic-resistant bacteria (ARB), the class 1 integrase gene (intI1), and 16 antibiotic resistance genes (ARGs) that confer resistance to 10 different clinically relevant antibiotics. A subset of 119 antibiotic-resistant isolates were phylogenetically classified and tested for the presence of ARGs encoding resistance to β-lactam antibiotics (bla NDM , bla KPC , bla SHV , bla CTX-M ), amikacin [aac(6')-Ib], co-trimoxazole (sul1, sul2, dfrA), ciprofloxacin (qnrA, qnrB), and the intI1 gene. Among these resistant isolates, 80.7% were detected with intI1 and 66.4% were found to carry at least 1 of the tested ARGs. Among 3 sampled locations, the clinical isolation ward had the highest concentrations of ARB and the highest levels of ARGs linked to resistance to β-lactam (bla KPC ), co-trimoxazole (sul1, sul2, dfrA), amikacin [aac(6')-Ib], ciprofloxacin (qnrA), and intI1 We found strong positive correlations (P < 0.05) between concentrations of bacteria resistant to meropenem, ceftazidime, amikacin, co-trimoxazole, and ciprofloxacin and abundances of bla KPC , aac(6')-Ib, sul1, sul2, dfrA, qnrA, and intI1 genes. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

A survey for red varibles INT he LMC - II

NASA Astrophysics Data System (ADS)

Reid, Neill; Glass, I. S.; Catchpole, R. M.

1988-05-01

Infrared photometry of a sample of 126 variables drawn from a 16 sq deg area of the northern LMC is presented. Most of these stars were previously unknown and the majority prove the be long period red-giant variables. Most of the latter stars fall within two groups in the /K(0), log(P)/ diagram, the lower luminosity ones being Miras which obey a definite period-luminosity relation. Using the latter stars as distance estimators is discussed. The /M(bol), P/ diagram is compared with the theoretical tracks calculated by Wood, Bessell & Fox (1983), and it is found that the distribution of stars is probably consistent with a lull in star formation in the LMC from about 10 to the 9th - 2 x 10 to the 8th yr ago, although this conclusion depends strongly on the luminosity at which stars of different initial mass enter the thermally pulsing AGB.

Collaborative Research: Simulation of Beam-Electron Cloud Interactions in Circular Accelerators Using Plasma Models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Katsouleas, Thomas; Decyk, Viktor

Final Report for grant DE-FG02-06ER54888, "Simulation of Beam-Electron Cloud Interactions in Circular Accelerators Using Plasma Models" Viktor K. Decyk, University of California, Los Angeles Los Angeles, CA 90095-1547 The primary goal of this collaborative proposal was to modify the code QuickPIC and apply it to study the long-time stability of beam propagation in low density electron clouds present in circular accelerators. The UCLA contribution to this collaborative proposal was in supporting the development of the pipelining scheme for the QuickPIC code, which extended the parallel scaling of this code by two orders of magnitude. The USC work was as describedmore » here the PhD research for Ms. Bing Feng, lead author in reference 2 below, who performed the research at USC under the guidance of the PI Tom Katsouleas and the collaboration of Dr. Decyk The QuickPIC code [1] is a multi-scale Particle-in-Cell (PIC) code. The outer 3D code contains a beam which propagates through a long region of plasma and evolves slowly. The plasma response to this beam is modeled by slices of a 2D plasma code. This plasma response then is fed back to the beam code, and the process repeats. The pipelining is based on the observation that once the beam has passed a 2D slice, its response can be fed back to the beam immediately without waiting for the beam to pass all the other slices. Thus independent blocks of 2D slices from different time steps can be running simultaneously. The major difficulty was when particles at the edges needed to communicate with other blocks. Two versions of the pipelining scheme were developed, for the the full quasi-static code and the other for the basic quasi-static code used by this e-cloud proposal. Details of the pipelining scheme were published in [2]. The new version of QuickPIC was able to run with more than 1,000 processors, and was successfully applied in modeling e-clouds by our collaborators in this proposal [3-8]. Jean-Luc Vay at Lawrence Berkeley National Lab later implemented a similar basic quasistatic scheme including pipelining in the code WARP [9] and found good to very good quantitative agreement between the two codes in modeling e-clouds. References [1] C. Huang, V. K. Decyk, C. Ren, M. Zhou, W. Lu, W. B. Mori, J. H. Cooley, T. M. Antonsen, Jr., and T. Katsouleas, "QUICKPIC: A highly efficient particle-in-cell code for modeling wakefield acceleration in plasmas," J. Computational Phys. 217, 658 (2006). [2] B. Feng, C. Huang, V. K. Decyk, W. B. Mori, P. Muggli, and T. Katsouleas, "Enhancing parallel quasi-static particle-in-cell simulations with a pipelining algorithm," J. Computational Phys, 228, 5430 (2009). [3] C. Huang, V. K. Decyk, M. Zhou, W. Lu, W. B. Mori, J. H. Cooley, T. M. Antonsen, Jr., and B. Feng, T. Katsouleas, J. Vieira, and L. O. Silva, "QUICKPIC: A highly efficient fully parallelized PIC code for plasma-based acceleration," Proc. of the SciDAC 2006 Conf., Denver, Colorado, June, 2006 [Journal of Physics: Conference Series, W. M. Tang, Editor, vol. 46, Institute of Physics, Bristol and Philadelphia, 2006], p. 190. [4] B. Feng, C. Huang, V. Decyk, W. B. Mori, T. Katsouleas, P. Muggli, "Enhancing Plasma Wakefield and E-cloud Simulation Performance Using a Pipelining Algorithm," Proc. 12th Workshop on Advanced Accelerator Concepts, Lake Geneva, WI, July, 2006, p. 201 [AIP Conf. Proceedings, vol. 877, Melville, NY, 2006]. [5] B. Feng, P. Muggli, T. Katsouleas, V. Decyk, C. Huang, and W. Mori, "Long Time Electron Cloud Instability Simulation Using QuickPIC with Pipelining Algorithm," Proc. of the 2007 Particle Accelerator Conference, Albuquerque, NM, June, 2007, p. 3615. [6] B. Feng, C. Huang, V. Decyk, W. B. Mori, G. H. Hoffstaetter, P. Muggli, T. Katsouleas, "Simulation of Electron Cloud Effects on Electron Beam at ERL with Pipelined QuickPIC," Proc. 13th Workshop on Advanced Accelerator Concepts, Santa Cruz, CA, July-August, 2008, p. 340 [AIP Conf. Proceedings, vol. 1086, Melville, NY, 2008]. [7] B. Feng, C. Huang, V. K. Decyk, W. B. Mori, P. Muggli, and T. Katsouleas, "Enhancing parallel quasi-static particle-in-cell simulations with a pipelining algorithm," J. Computational Phys, 228, 5430 (2009). [8] C. Huang, W. An, V. K. Decyk, W. Lu, W. B. Mori, F. S. Tsung, M. Tzoufras, S. Morshed, T. Antonsen, B. Feng, T. Katsouleas, R., A. Fonseca, S. F. Martins, J. Vieira, L. O. Silva, E. Esarey, C. G. R. Geddes, W. P. Leemans, E. Cormier-Michel, J.-L. Vay, D. L. Bruhwiler, B. Cowan, J. R. Cary, and K. Paul, "Recent results and future challenges for large scale particleion- cell simulations of plasma-based accelerator concepts," Proc. of the SciDAC 2009 Conf., San Diego, CA, June, 2009 [Journal of Physics: Conference Series, vol. 180, Institute of Physics, Bristol and Philadelphia, 2009], p. 012005. [9] J.-L. Vay, C. M. Celata, M. A. Furman, G. Penn, M. Venturini, D. P. Grote, and K. G. Sonnad, ?Update on Electron-Cloud Simulations Using the Package WARP-POSINST.? Proc. of the 2009 Particle Accelerator Conference PAC09, Vancouver, Canada, June, 2009, paper FR5RFP078.« less

Enhanced Condensation of R-113 on a Small Bundle of Horizontal Tubes

DTIC Science & Technology

1991-12-01

Anthony J. l lcaley, Ch an )epartment of Mechanic’ Engineering ABSTRACT Condensation of R-113 was studied using an evaporator/condenser test platform. The...IF 7825 FOR I=1 TO Npair5 7830 ENTER @File;Xa,Ya 7835 S×=Sx+Xa 7840 Sy=Sy+Ya 7845 5x2=Sx2+XaŖ 7850 Sxy-Sxy+Xa*Ya 7855 X=(Xa-Xmin)*Sfx 7860 Y-(Ya-Ymin...9th Int. Heat Transfer Conf., Vol. 3, pp. 15-20, 1990. 33. Fujii, T., Wang, W. Ch ., Koyama, Sh. and Y. Shimizu, Heat Transfer Enhancement for Gravity

Work cost of thermal operations in quantum thermodynamics

NASA Astrophysics Data System (ADS)

Renes, Joseph M.

2014-07-01

Adopting a resource theory framework of thermodynamics for quantum and nano systems pioneered by Janzing et al. (Int. J. Th. Phys. 39, 2717 (2000)), we formulate the cost in the useful work of transforming one resource state into another as a linear program of convex optimization. This approach is based on the characterization of thermal quasiorder given by Janzing et al. and later by Horodecki and Oppenheim (Nat. Comm. 4, 2059 (2013)). Both characterizations are related to an extended version of majorization studied by Ruch, Schranner and Seligman under the name mixing distance (J. Chem. Phys. 69, 386 (1978)).

Transition Region for Corner Cracks at Holes.

DTIC Science & Technology

1984-12-01

that ca<tastrophic failures are not caused by cracks ormin;i I i g f ro.m fast ener ho I es . This philosophy was introduced by \\;Lood aind im, l12...form throusgh- * hi fininit~ 1w b ouindaries of this reuiion is .1 , t nd rk . i’ It he l .iSclissed inT det ail in i r , -n Iv, rm ed u r es o(r (I ,i...or these results dealing strictly wi th part-t brougil c:ac k fat i que life pr-edictions in 1979, (see Chang [301). Peterson andl Vroman [31 1

Transonic and Supersonic Phenomena in Turbomachines: Proceedings of the Propulsion and Energetics (68th)(B) Specialists’ Meeting Held in Munich, Germany on 10-12 September 1986

DTIC Science & Technology

1987-03-01

stoepos Cft #A issoe lawd- tiop ~I VUse.e 85 d ’o 1 W., do wnoed foyer col Point* singuliers d’un 6coulement paridtal 𔃻 0i est enusufte oaanv I int...Blades", D. Phil Thesis , University of Oxford, 1983. * NOMA. 4-- THE BOUNDARY LAYER BEHAVIOUR OF HIGHLY LOADED COMPRESSOR 0 CASCADE AT TRANSONIC PLOW...Phenomena in Transonic Comprossors," MIT Ph.D. Thesis , September 1985. 12. McCune, J.E., "Theoretical Modelling of Stability and Unsteadiness in

An Interview with Jim Webb

DTIC Science & Technology

2010-12-01

decorated combat marine in Vietnam, assistant Secretary of defense, and Secretary of the Navy . C ou rt es y of th e O ffi ce o f S en at or Ji m...W eb b 146 | INteRVIeWS PRISM 2, no. 1 webb at the size of the Navy right now; its floor for strategic planning is 313 ships. The Navy is now, I...went from 930 down to 479 post-Vietnam, and we got it up to 568 when I was Secretary of the Navy ; now we’re back down to nearly 290. That is our

Proceedings of the Ship Control Systems Symposium (5th), Held at U. S. Naval Academy, Annapolis, Maryland on October 30 - November 3, 1978. Volume 6,

DTIC Science & Technology

1978-11-03

Engineering with endorsements in Control Engineering and Applied Electronics. He joined his present company , Y-ARD Ltd, in 1972 and has been primarily...functions Io, II is 8(t 2-a 2). These formulae are derived on the assumption that the medium is infinite in extent; so they only apply if both source and...The author is indebted to the Danish Shipping Company A.P.Moller for providing the data from the full scale experiments. C 3-26 i. = -- -nm.i i Int I

3 CFR 102.171-102.999 - [Reserved

Code of Federal Regulations, 2012 CFR

2012-01-01

... Childhood Obesity Awareness Month, 2011 55207 8703 Sept. 1 National Ovarian Cancer Awareness Month, 2011...)Child Health Day (Proc. 8729)Childhood Cancer Awareness Month, National (Proc. 8705)Childhood Obesity...

Toxic Aerosols and Pathogenic Bioaerosols

DTIC Science & Technology

2016-04-01

le s / c m 3 Po int 1...a 50- LPM Challenge (n = 3) Sample Location 0. 8 um p ar tic le s / c m 3 Po int 1 Po int 2 Po int 3 Po int 4 Po int 5 0 1000 2000 3000 4000...Minutes) 0. 8 um p ar tic le s / c m 3 0 10 20 30 40 50 0 1000 2000 3000 Point 1 Point 2 Point 3 Point 4 Point 5 Figure 9. 0.8-μm

Practically prepared? Pre-intern student views following an education package.

PubMed

McKenzie, Susan; Mellis, Craig

2017-01-01

Graduating medical students enter their internship with varied levels of practical experience in procedural skills. To address this problem, many medical schools have introduced intensive skill training courses immediately prior to graduation. This study examines the impact of a pre-intern (PrInt) education package, consisting of a short intensive course, followed by a one-month clinical attachment. In September 2014, all PrInt students (n = 53) at the Central Clinical School (Sydney, NSW, Australia) attended three days of intensive training. This included a didactic introduction, case-based scenarios, and interactive workshops. This was followed by four weeks of targeted, experiential learning during a clinical attachment (PrInt term). Immediately prior to training and following PrInt, all students were invited to complete a six-domain questionnaire containing 40 subscale closed questions to assess their knowledge, experience, and confidence in key practical skills essential for a successful internship. A total of 41/53 (77%) students completed an identical questionnaire prior to PrInt, and 37/53 (70%) immediately following PrInt. Respondents reported statistically significant increases in their experience, ability, knowledge, and confidence in a number of domains. The key changes were the following: knowledge of pharmacy skills (mean improvement = 26.48, confidence interval 95% [CI 95%] = 17.29-35.66, p ≤ 0.0001) and management of procedural skills (mean = 24.46, CI 95% = 16.58-32.34, p ≤ 0.0001). Despite the positive overall increase in most domains, some subscale results remained low following the educational package; only 44% students had inserted a nasogastric tube; only 44% reported confidence in commencing patients on warfarin; and only 42% in managing a hospital emergency. Surprisingly, there was a slight decline both in confidence in communicating with members of the hospital team (10%) and in awareness of the causes of hypoglycemia (7%). Final year students perceived substantial benefit from an educational package specifically aimed at improving their practical skills immediately prior to internship.

Practically prepared? Pre-intern student views following an education package

PubMed Central

McKenzie, Susan; Mellis, Craig

2017-01-01

Background Graduating medical students enter their internship with varied levels of practical experience in procedural skills. To address this problem, many medical schools have introduced intensive skill training courses immediately prior to graduation. This study examines the impact of a pre-intern (PrInt) education package, consisting of a short intensive course, followed by a one-month clinical attachment. Methods In September 2014, all PrInt students (n = 53) at the Central Clinical School (Sydney, NSW, Australia) attended three days of intensive training. This included a didactic introduction, case-based scenarios, and interactive workshops. This was followed by four weeks of targeted, experiential learning during a clinical attachment (PrInt term). Immediately prior to training and following PrInt, all students were invited to complete a six-domain questionnaire containing 40 subscale closed questions to assess their knowledge, experience, and confidence in key practical skills essential for a successful internship. Results A total of 41/53 (77%) students completed an identical questionnaire prior to PrInt, and 37/53 (70%) immediately following PrInt. Respondents reported statistically significant increases in their experience, ability, knowledge, and confidence in a number of domains. The key changes were the following: knowledge of pharmacy skills (mean improvement = 26.48, confidence interval 95% [CI 95%] = 17.29–35.66, p ≤ 0.0001) and management of procedural skills (mean = 24.46, CI 95% = 16.58–32.34, p ≤ 0.0001). Despite the positive overall increase in most domains, some subscale results remained low following the educational package; only 44% students had inserted a nasogastric tube; only 44% reported confidence in commencing patients on warfarin; and only 42% in managing a hospital emergency. Surprisingly, there was a slight decline both in confidence in communicating with members of the hospital team (10%) and in awareness of the causes of hypoglycemia (7%). Conclusion Final year students perceived substantial benefit from an educational package specifically aimed at improving their practical skills immediately prior to internship. PMID:28184172

3 CFR 102.171-102.999 - [Reserved

Code of Federal Regulations, 2013 CFR

2013-01-01

... Month, 2012 55091 8852 Aug. 31 National Childhood Obesity Awareness Month, 2012 55093 8853 Aug. 31...)Child Health Day (Proc. 8880)Childhood Cancer Awareness Month, National (Proc. 8851)Childhood Obesity...

3 CFR 102.171-102.999 - [Reserved

Code of Federal Regulations, 2014 CFR

2014-01-01

..., 2013 54737 9007 Aug. 30 National Childhood Obesity Awareness Month, 2013 54739 9008 Aug. 30 National... Health Day (Proc. 9036)Childhood Cancer Awareness Month, National (Proc. 9006)Childhood Obesity Awareness...

Coilable Crystalline Fiber (CCF) Lasers and their Scalability

DTIC Science & Technology

2014-03-01

Fibers: Double-Clad Design Concept of Tm:YAG-Core Fiber and Mode Simulation. Proc. SPIE 2012, 8237 , 82373M. 8. Beach, R. J.; Mitchell, S. C...Dubinskii, M. True Crystalline Fibers: Double-Clad LMA Design Concept of Tm:YAG-Core Fiber and Mode Simulation. Proc. of SPIE 2012, 8237 , 82373M-1...Tm:YAG-Core Fiber and Mode Simulation. Proc. SPIE 8237 , 82373M, 2012. 8. Beach, R. J.; Mitchell, S. C.; Meissner, H. E.; Meissner, O. R.; Krupke, W

Analysis of the Proposed Implementation of the New Army Communications and Information Systems Specialist (ACISS) Trade using the Managed Readiness Simulator (MARS)

DTIC Science & Technology

2011-11-01

Christine Scales; RDRDC CORA TM 2011- 194; R & D pour la défense Canada – CORA; Novembre 2011 Introduction ou contexte : L’Armée de terre procède... 13 2.7.1 New Recruits through DP1 Level ................................................................. 14 2.7.2 DP1 Level through DP2...Figure 13 : ACISS Positions filled in the Proposed Structure over 12 years ................................. 22 Figure 14: Trained Recruits waiting to

Tandem Repeat Regions within the Burkholderia pseudomallei Genome and their Application for High-Resolution Genotyping

DTIC Science & Technology

2007-03-30

is marked by gene dele- tions and intra-chromosomal rearrangements [4-7]. B. mallei , the etiologic agent of glanders , is an obligate para- site of the...CM: Structural flexi- bility in the Burkholderia mallei genome. Proc Natl Acad Sci U S A 2004, 101(39):14246-14251. 6. Godoy D, Randle G, Simpson AJ...and glanders , Burkholderia pseudomallei and Burkholderia mal- lei. J Clin Microbiol 2003, 41(5):2068-2079. 7. Kim HS, Schell MA, Yu Y, Ulrich RL

Development of the Microwave Radiative Transfer Program for Cloudy Atmospheres: Applications to DMSP SSM/T Channels.

DTIC Science & Technology

1979-12-30

42.22 122.52 Cloudy Green Bay 0253 Z Wisconsin (WI) 23 Nov 79 44.29 88.08 Cloudy Monterrey 0429 Z Mexico (MEX) 23 Nov 79 25.52 100.12 Cloudy Dodge City...230 250 270 290 - 35 35 Ii 30 30 / 25 / MONTERREY, MEXICO 25 GREEN DAY. WISCONSIN 23 NOV. 79,OOZ,0429Z 23 NOV. 79,OOZ,02 53Z - RAOS i -- RAO 20...bINDOW/ UP1NG2.INT)eDW(NG2.INT)eTHETA(t4),NU(INT)eLv(INT~e ICK~IINT).CK2(lNT).6UVERT(INI).CDVERT(INT) COMMON /MADATA/ PINIINGvINT) .PTIINT) . SEXT (INT

Effects of substrates and phosphate on INT (2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyl tetrazolium chloride) and CTC (5-cyano-2,3-ditolyl tetrazolium chloride) reduction in Escherichia coli

NASA Technical Reports Server (NTRS)

Smith, J. J.; McFeters, G. A.

1996-01-01

The effects of substrates of primary aerobic dehydrogenases, and inorganic phosphate on aerobic INT and CTC reduction in Escherichia coli were examined. In general, INT produced less formazan than CTC, but INT (+) cell counts remained near values of CTC (+) cells. INT and CTC (+) cell numbers were higher than plate counts on R2A medium using succinate, formate, lactate, casamino acids, glucose, glycerol (INT only) and no substrate. Formate resulted in the greatest amount of INT and CTC formazan. Reduction of both INT and CTC was inhibited above 10 mmol l-1 phosphate, and this appeared to be related to decreased rates of O2 consumption. Formation of fluorescent CTC (+), but not INT (+) cells was also inhibited in a concentration dependent manner by phosphate above 10 mmol l-1. From light microscopic observations it appeared CTC formed increasing amounts of poorly or non-fluorescent formazan with increasing phosphate. Therefore, use of phosphate buffer in excess of 10 mmol l-1 may not be appropriate in CTC and INT reduction assays.

Individual fluid plans versus ad libitum on hydration status in minor professional ice hockey players.

PubMed

Emerson, Dawn M; Torres-McGehee, Toni M; Emerson, Charles C; LaSalle, Teri L

2017-01-01

Despite exercising in cool environments, ice hockey players exhibit several dehydration risk factors. Individualized fluid plans (IFPs) are designed to mitigate dehydration by matching an individual's sweat loss in order to optimize physiological systems and performance. A randomized control trial was used to examine IFP versus ad libitum fluid ingestion on hydration in 11 male minor professional ice hockey players (mean age = 24.4 ± 2.6 years, height = 183.0 ± 4.6 cm, weight = 92.9 ± 7.8 kg). Following baseline measures over 2 practices, participants were randomly assigned to either control (CON) or intervention (INT) for 10 additional practices. CON participants were provided water and/or carbohydrate electrolyte beverage to drink ad libitum. INT participants were instructed to consume water and an electrolyte-enhanced carbohydrate electrolyte beverage to match sweat and sodium losses. Urine specific gravity, urine color, and percent body mass change characterized hydration status. Total fluid consumed during practice was assessed. INT consumed significantly more fluid than CON (1180.8 ± 579.0 ml vs. 788.6 ± 399.7 ml, p  = 0.002). However, CON participants replaced only 25.4 ± 12.9% of their fluid needs and INT 35.8 ± 17.5%. Mean percent body mass loss was not significantly different between groups and overall indicated minimal dehydration (<1.2% loss). Pre-practice urine specific gravity indicated CON and INT began hypohydrated (mean = 1.024 ± 0.007 and 1.024 ± 0.006, respectively) and experienced dehydration during practice (post = 1.026 ± 0.006 and 1.027 ± 0.005, respectively, p  < 0.001). Urine color increased pre- to post-practice for CON (5 ± 2 to 6 ± 1, p  < 0.001) and INT (5 ± 1 to 6 ± 1, p <  0.001). Participants consistently reported to practice hypohydrated. Ad libitum fluid intake was not significantly different than IFP on hydration status. Based on urine measures, both methods were unsuccessful in preventing dehydration during practice, suggesting practice-only hydration is inadequate to maintain euhydration in this population when beginning hypohydrated.

Genome-wide Analysis of Germline CNPs and SNPs in Prostate Cancer

DTIC Science & Technology

2010-03-01

colorectal adenomas. Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):15992-7. 12) Iliopoulos D, Guler G, Han SY, Druck T, Ottey M, McCorkell KA...SNPs and copy number variation. Nat Genet. 2008 Oct;40(10):1166-74. 17) Qin HR, Iliopoulos D, Semba S, Fabbri M, Druck T, Volinia S, Croce CM

Autonomous Adaptive Acoustic Relay Positioning

DTIC Science & Technology

2013-09-01

underwater acoustic sensor networks . In Proc. 1st ACM International Work- shop on Underwater Networks , pages 7–16, 2006. [4] A Alvarez, A...routing in underwater delay/disruption tolerant sensor networks . In Wireless on Demand Network Systems and Services, 2008. WONS 2008. Fifth Annual...the development of multi-vehicle applications in the ocean, and the main mode of wireless data transmission underwater is acoustic .

MBL, P2X7, and SLC11A1 gene polymorphisms in patients with oropharyngeal tularemia.

PubMed

Somuk, Battal Tahsin; Koc, Sema; Ates, Omer; Göktas, Göksel; Soyalic, Harun; Uysal, Ismail Onder; Gurbuzler, Levent; Sapmaz, Emrah; Sezer, Saime; Eyibilen, Ahmet

2016-11-01

A significant association was found of oropharyngeal tularemia with SLC11A1 allele polymorphism (INT4 G/C) and MBL2 C + 4T (P/Q). These results indicate C allele and Q allele might be a risk factor for the development of oropharyngeal tularemia. This study aimed to investigate the relationship of SLC11A1, MBL, and P2X 7 gene polymorphism with oropharyngeal tularemia. The study included totally 120 patients who were diagnosed with oropharyngeal tularemia. Frequencies of polymorphisms in the following genes were analyzed both in the patient and control groups in the study: SLC11A1 (5'(GT) n Allele 2/3, Int4 G/C, 3' UTR, D543N G/A), MBL (MBL2 C + 4T (P/Q), and P2X 7 (-762 C/T and 1513 A/C). Among all polymorphisms that were investigated in this study, SLC11A1 gene showed a significance in the distriburtion of polymorphism allelle frequency at the INT4 region. Frequency of C allele was 54 (28%) in patients with oropharyngeal tularemia, and 31 (13%) in the control group (p = 0.006 and OR = 1.96 (1.21-3.20)). An association was detected between MBL2 C + 4T (P/Q) gene polymorphism and oropharyngeal tularemia (p < 0.005 and OR = 0.30 (0.19-0.48)). No significant relation was found between P2X 7 (-762 C/T and 1513 A/C) gene polymorphism and oropharyngeal tularemia in this study (p > 0.05).

pROC: an open-source package for R and S+ to analyze and compare ROC curves.

PubMed

Robin, Xavier; Turck, Natacha; Hainard, Alexandre; Tiberti, Natalia; Lisacek, Frédérique; Sanchez, Jean-Charles; Müller, Markus

2011-03-17

Receiver operating characteristic (ROC) curves are useful tools to evaluate classifiers in biomedical and bioinformatics applications. However, conclusions are often reached through inconsistent use or insufficient statistical analysis. To support researchers in their ROC curves analysis we developed pROC, a package for R and S+ that contains a set of tools displaying, analyzing, smoothing and comparing ROC curves in a user-friendly, object-oriented and flexible interface. With data previously imported into the R or S+ environment, the pROC package builds ROC curves and includes functions for computing confidence intervals, statistical tests for comparing total or partial area under the curve or the operating points of different classifiers, and methods for smoothing ROC curves. Intermediary and final results are visualised in user-friendly interfaces. A case study based on published clinical and biomarker data shows how to perform a typical ROC analysis with pROC. pROC is a package for R and S+ specifically dedicated to ROC analysis. It proposes multiple statistical tests to compare ROC curves, and in particular partial areas under the curve, allowing proper ROC interpretation. pROC is available in two versions: in the R programming language or with a graphical user interface in the S+ statistical software. It is accessible at http://expasy.org/tools/pROC/ under the GNU General Public License. It is also distributed through the CRAN and CSAN public repositories, facilitating its installation.

Polymorphisms in antithrombin and in tissue factor pathway inhibitor genes are associated with recurrent pregnancy loss.

PubMed

Guerra-Shinohara, Elvira M; Bertinato, Juliano Felix; Tosin Bueno, Carolina; Cordeiro da Silva, Kelma; Burlacchini de Carvalho, Mário Henrique; Pulcineli Vieira Francisco, Rossana; Zugaib, Marcelo; Cerda, Alvaro; Morelli, Vânia Maris

2012-10-01

Recurrent pregnancy loss (RPL) is a multifactorial condition. The effect of antithrombin (SERPINC1), protein C (PROC), thrombomodulin (THBD) and tissue factor pathway inhibitor (TFPI) single nucleotide polymorphisms (SNPs) on the risk of RPL is thus far unknown. Our objective was to determine the association of SNPs in the above mentioned genes with RPL. We included 117 non-pregnant women with three or more consecutive losses prior to 20 weeks of pregnancy without a previous history of carrying a fetus to viability, and 264 healthy fertile non-pregnant women who had at least two term deliveries and no known pregnancy losses. The PROC (rs1799809 and rs1799808), SERPINC1 (rs2227589), THBD (rs1042579) and TFPI (rs10931292, rs8176592 and rs10153820) SNPs were analysed by Real Time PCR. Genotype frequencies for PROC 2418A>G, PROC 2405C>T, THBD 1418C>T, TFPI (T-33C and TFPI C-399T) SNPs were similar in cases and controls. The carriers of SERPINC1 786A allele (GA + AA genotypes) had an increased risk for RPL (odds ratio [OR]: 1.77, 95% confidence interval [CI]: 1.05-3.00, p= 0.034) while women carrying the TFPI -287C allele (TC + CC genotypes) had a protection effect on having RPL (OR: 0.46, 95% CI: 0.26-0.83, p= 0.009). The TCC haplotype for TFPI T-33C/ TFPI T-287C/ TFPI C-399T SNPs was less frequent in cases (5.7%) than in controls (11.6%) (OR: 0.45, 95% CI: 0.23-0.90, p= 0.025). In conclusion, our data indicate that SERPINC1 786G>A variant increases the risk for RPL, while TFPI T-287C variant is protective; however, further studies are required to confirm our findings.

Low doses of allergen and probiotic supplementation separately or in combination alleviate allergic reactions to cow β-lactoglobulin in mice.

PubMed

Thang, Cin L; Boye, Joyce I; Zhao, Xin

2013-02-01

Probiotic supplementation and oral tolerance induction can reduce certain types of food allergy. The objectives of this study were to investigate the allergy-reducing effects of probiotics (VSL#3) and/or oral tolerance induction via low doses of an allergen supplementation in β-lactoglobulin (BLG)-sensitized mice. Three-week-old, male BALB/c mice were divided into 6 groups (n = 8/group): sham-sensitized negative control (CTL-), BLG-sensitized positive control (CTL+), oral tolerance-induced and BLG-sensitized group (OT), probiotic-supplemented OT group (OTP), probiotic-supplemented CTL- (PRO), and probiotic-supplemented and BLG-sensitized (PROC) groups. Mice were i.p. sensitized with BLG and alum and then orally challenged with BLG. Immunological responses were assessed by monitoring hypersensitivity scores and measuring levels of BLG-specific serum Igs, total serum IgE and fecal IgA, and cytokines from serum and spleen lysates. Hypersensitivity scores were significantly lower in the PROC (2.00 ± 0.53), OT (0.75 ± 0.46), and OTP mice (1.00 ± 0.53) than in the CTL+ mice (2.63 ± 0.52) as were BLG-specific serum IgE concentrations (34.3 ± 10, 0.442 ± 0.36, 3.54 ± 3.5, and 78.5 ± 8.7 μg/L for PROC, OT, OTP, and CTL+, respectively). Our results suggest that supplementation of VSL#3 suppressed the allergic reaction mainly through increased intestinal secretary IgA (sIgA) in PROC mice, and oral tolerance offered allergen-specific protective effects to BLG-induced allergy, probably through CD4+CD25+ regulatory T cell-mediated active suppression. In OTP mice, probiotics did not induce a further reduction of hypersensitivity score compared with OT mice but may provide additional protection to unforeseen nonspecific challenges through increased intestinal sIgA.

Decreased eIF3e/Int6 expression causes epithelial-to-mesenchymal transition in breast epithelial cells.

PubMed

Gillis, L D; Lewis, S M

2013-08-01

eIF3e/Int6 is a component of the multi-subunit eIF3 complex, which binds directly to the 40S ribosome to facilitate ribosome recruitment to mRNA and hence protein synthesis. Reduced expression of eIF3e/Int6 has been found in up to 37% of human breast cancers, and expression of a truncated mutant version of the mouse eIF3e/Int6 protein leads to malignant transformation of normal mammary cells. These findings suggest that eIF3e/Int6 is a tumor suppressor; however, a recent study has reported that a reduction of eIF3e/Int6 expression in breast cancer cells leads to reduced translation of oncogenes, suggesting that eIF3e/Int6 may in fact have an oncogenic role in breast cancer. To gain a better understanding of the role of eIF3e/Int6 in breast cancer, we have examined the effects of decreased eIF3e/Int6 expression in an immortalized breast epithelial cell line, MCF-10A. Surprisingly, we find that decreased expression of eIF3e/Int6 causes breast epithelial cells to undergo epithelial-to-mesenchymal transition (EMT). We show that EMT induced by a decrease in eIF3e/Int6 expression imparts invasive and migratory properties to breast epithelial cells, suggesting that regulation of EMT by eIF3e/Int6 may have an important role in breast cancer metastasis. Furthermore, we show that reduced eIF3e/Int6 expression in breast epithelial cells causes a specific increase in the expression of the key EMT regulators Snail1 and Zeb2, which occurs at both the transcriptional and post-transcriptional levels. Together, our data indicate a novel role of eIF3e/Int6 in the regulation of EMT in breast epithelial cells and support a tumor suppressor role of eIF3e/Int6.

The MIntAct project—IntAct as a common curation platform for 11 molecular interaction databases

PubMed Central

Orchard, Sandra; Ammari, Mais; Aranda, Bruno; Breuza, Lionel; Briganti, Leonardo; Broackes-Carter, Fiona; Campbell, Nancy H.; Chavali, Gayatri; Chen, Carol; del-Toro, Noemi; Duesbury, Margaret; Dumousseau, Marine; Galeota, Eugenia; Hinz, Ursula; Iannuccelli, Marta; Jagannathan, Sruthi; Jimenez, Rafael; Khadake, Jyoti; Lagreid, Astrid; Licata, Luana; Lovering, Ruth C.; Meldal, Birgit; Melidoni, Anna N.; Milagros, Mila; Peluso, Daniele; Perfetto, Livia; Porras, Pablo; Raghunath, Arathi; Ricard-Blum, Sylvie; Roechert, Bernd; Stutz, Andre; Tognolli, Michael; van Roey, Kim; Cesareni, Gianni; Hermjakob, Henning

2014-01-01

IntAct (freely available at http://www.ebi.ac.uk/intact) is an open-source, open data molecular interaction database populated by data either curated from the literature or from direct data depositions. IntAct has developed a sophisticated web-based curation tool, capable of supporting both IMEx- and MIMIx-level curation. This tool is now utilized by multiple additional curation teams, all of whom annotate data directly into the IntAct database. Members of the IntAct team supply appropriate levels of training, perform quality control on entries and take responsibility for long-term data maintenance. Recently, the MINT and IntAct databases decided to merge their separate efforts to make optimal use of limited developer resources and maximize the curation output. All data manually curated by the MINT curators have been moved into the IntAct database at EMBL-EBI and are merged with the existing IntAct dataset. Both IntAct and MINT are active contributors to the IMEx consortium (http://www.imexconsortium.org). PMID:24234451

Soil Biogeochemical Properties and Erosion Source Prediction Model Summary for the Buffalo Bayou Watershed, Houston, Texas

NASA Astrophysics Data System (ADS)

Ahmed, I.

2015-12-01

We draw conclusions on the research output and findings from a 4-year multidisciplinary USDA-CBG collaborative program in sustainable integrated monitoring of soil organic carbon (SOC) loss prediction via erosion. The underlying method uses the state-of-the-art stable isotope science of sediment tracing under uncertain hydrologic influences. The research finds are rooted in the (i) application of Bayesian Markov Chain Monte Carlo statistical models to assess the relationship between rainfall-runoff and soil erosion in space and time, (ii) capture of the episodic nature of rainfall events and its role in the spatial distribution of SOC loss from water erosion, (iii) stable isotope composition guided fingerprinting (source and quantity) of eroded soil, and (iv) the creation of an integrated watershed scale statistical soil loss monitoring model driven by spatial and temporal correlation of flow and stable isotope composition. The research theme was successfully applied on the urbanized Buffalo Bayou Watershed in Houston, Texas. The application brought to light novel future research conceptual outlines which will also be discussed in this deliverable to the AGU meeting. These include but not limited to: regional rainfall cluster research, physics of muddy river-bank soil and suspended sediment interaction, and friction & mobility that together make up the plasticity of soil aggregates that control erosion processes and landscape changes in a riparian corridor. References: Ahmed, I., Karim, A., Boutton, T.W., and Strom, K.B. (2013a). "Monitoring Soil Organic Carbon Loss from Erosion Using Stable Isotopes." Proc., Soil Carbon Sequestration, International Conference, May 26-29, Reykjavik, Iceland. Ahmed, I, Bouttom, T.W., Strom, K. B., Karim, A., and Irvin-Smith, N. (2013b). "Soil carbon distribution and loss monitoring in the urbanized Buffalo Bayou watershed, Houston, Texas." Proc., 4th Annual All Investigators Meeting of the North American Carbon Program, February 4-7, Albuquerque, NM. Fox, J.F. and Papanicolaou, A.N. (2008). An un-mixing model to study watershed erosion processes. Advances in Water Resources, 31, 96-108.

Cognitive inhibition of number/length interference in a Piaget-like task in young adults: evidence from ERPs and fMRI.

PubMed

Leroux, Gaëlle; Joliot, Marc; Dubal, Stéphanie; Mazoyer, Bernard; Tzourio-Mazoyer, Nathalie; Houdé, Olivier

2006-06-01

We sought to determine whether the neural traces of a previous cognitive developmental stage could be evidenced in young adults. In order to do so, 12 young adults underwent two functional imaging acquisitions (EEG then fMRI). During each session, two experimental conditions were applied: a Piaget-like task with number/length interference (INT), and a reference task with number/length covariation (COV). To succeed at Piaget's numerical task, which children under the age of 7 years usually fail, the subjects had to inhibit a misleading strategy, namely, the visuospatial length-equals-number bias, a quantification heuristic that is often relevant and that continues to be used through adulthood. Behavioral data confirmed that although there was an automation in the young adult subjects as assessed by the very high number of accurate responses (>97%), the inhibition of the "length equals number strategy" had a cognitive cost, as the reaction times were significantly higher in INT than in COV (with a difference of 230 ms). The event-related potential results acquired during the first session showed electrophysiological markers of the cognitive inhibition of the number/length interference. Indeed, the frontal N2 was greater during INT than during COV, and a P3(late)/P6 was detected only during INT. During the fMRI session, a greater activation of unimodal areas (the right middle and superior occipital cortex) and in the ventral route (the left inferior temporal cortex) was observed in INT than in COV. These results seem to indicate that when fully automated in adults, inhibition processes might take place in unimodal areas. Copyright 2005 Wiley-Liss, Inc.

Lin- CD34hi CD117int/hi FcεRI+ cells in human blood constitute a rare population of mast cell progenitors.

PubMed

Dahlin, Joakim S; Malinovschi, Andrei; Öhrvik, Helena; Sandelin, Martin; Janson, Christer; Alving, Kjell; Hallgren, Jenny

2016-01-28

Mast cells are rare tissue-resident immune cells that are involved in allergic reactions, and their numbers are increased in the lungs of asthmatics. Murine lung mast cells arise from committed bone marrow-derived progenitors that enter the blood circulation, migrate through the pulmonary endothelium, and mature in the tissue. In humans, mast cells can be cultured from multipotent CD34(+) progenitor cells. However, a population of distinct precursor cells that give rise to mast cells has remained undiscovered. To our knowledge, this is the first report of human lineage-negative (Lin(-)) CD34(hi) CD117(int/hi) FcεRI(+) progenitor cells, which represented only 0.0053% of the isolated blood cells in healthy individuals. These cells expressed integrin β7 and developed a mast cell-like phenotype, although with a slow cell division capacity in vitro. Isolated Lin(-) CD34(hi) CD117(int/hi) FcεRI(+) blood cells had an immature mast cell-like appearance and expressed high levels of many mast cell-related genes as compared with human blood basophils in whole-transcriptome microarray analyses. Furthermore, serglycin, tryptase, and carboxypeptidase A messenger RNA transcripts were detected by quantitative reverse transcription-polymerase chain reaction. Altogether, we propose that the Lin(-) CD34(hi) CD117(int/hi) FcεRI(+) blood cells are closely related to human tissue mast cells and likely constitute an immediate precursor population, which can give rise to predominantly mast cells. Furthermore, asthmatics with reduced lung function had a higher frequency of Lin(-) CD34(hi) CD117(int/hi) FcεRI(+) blood mast cell progenitors than asthmatics with normal lung function. © 2016 by The American Society of Hematology.

Productivity losses associated with tuberculosis deaths in the World Health Organization African region.

PubMed

Kirigia, Joses Muthuri; Muthuri, Rosenabi Deborah Karimi

2016-06-01

In 2014, almost half of the global tuberculosis deaths occurred in the World Health Organization (WHO) African Region. Approximately 21.5 % of the 6 060 742 TB cases (new and relapse) reported to the WHO in 2014 were in the African Region. The specific objective of this study was to estimate future gross domestic product (GDP) losses associated with TB deaths in the African Region for use in advocating for better strategies to prevent and control tuberculosis. The cost-of-illness method was used to estimate non-health GDP losses associated with TB deaths. Future non-health GDP losses were discounted at 3 %. The analysis was conducted for three income groups of countries. One-way sensitivity analysis at 5 and 10 % discount rates was undertaken to assess the impact on the expected non-health GDP loss. The 0.753 million tuberculosis deaths that occurred in the African Region in 2014 would be expected to decrease the future non-health GDP by International Dollars (Int$) 50.4 billion. Nearly 40.8, 46.7 and 12.5 % of that loss would come from high and upper-middle- countries or lower-middle- and low-income countries, respectively. The average total non-health GDP loss would be Int$66 872 per tuberculosis death. The average non-health GDP loss per TB death was Int$167 592 for Group 1, Int$69 808 for Group 2 and Int$21 513 for Group 3. Tuberculosis exerts a sizeable economic burden on the economies of the WHO AFR countries. This implies the need to strongly advocate for better strategies to prevent and control tuberculosis and to help countries end the epidemic of tuberculosis by 2030, as envisioned in the United Nations General Assembly resolution on Sustainable Development Goals (SDGs).

Proposal of a novel system for the staging of thymic epithelial tumors.

PubMed

Bedini, Amedeo Vittorio; Andreani, Stefano Michele; Tavecchio, Luca; Fabbri, Alessandra; Giardini, Roberto; Camerini, Tiziana; Bufalino, Rosaria; Morabito, Alberto; Rosai, Juan

2005-12-01

We designed and assessed a new TNM staging system (herein called the INT [Istituto Nazionale Tumori] system) for thymic epithelial tumors in order to overcome the perceived drawbacks of Masaoka's system, which represents the current standard. In all, 123 cases were evaluated. The histologic types according to the World Health Organization (WHO) classification were as follows: subtype A: 5 cases; AB: 40; B1: 16; B2: 29; B3: 16; and C: 17 cases. There were 45 Masaoka's stage I, 33 stage II, 26 stage III, and 19 stage IV cases. A total of 11 INT definitions were grouped into three stages: locally restricted disease (75 cases), which included Masaoka's stage I and selected stage II cases (no pleural invasion); locally advanced disease (37 cases), which included Masaoka's stage III cases plus those staged II owing to pleural invasion and those staged IV owing to intrathoracic nodal or limited pleuropericardial involvement; and systemic disease (11 cases), which included the remaining Masaoka's stage IV cases. Completeness of resection, WHO types, and both staging systems were significant prognostic factors (p < 0.0001) on univariate analysis. The 95-month progression-free survival rates according to Masaoka's system were stage I: 100%; II: 93.6%; III: 46.3%; and IV: 23.2%. The INT system corresponding figures were as follows: locally restricted disease: 98.6%; locally advanced disease: 46.9%; and systemic disease: 11.7%. The INT system was the prognostic factor with the greatest impact (p = 0.0218) on multivariate analysis (Masaoka's system: p = 0.2012; completeness of resection: p = 0.6855; histology: p = 0.9386). The INT system allows finer disease descriptions than Masaoka's system, resulting in a stage grouping with higher prognostic distinctiveness.

PROC IRT: A SAS Procedure for Item Response Theory

PubMed Central

Matlock Cole, Ki; Paek, Insu

2017-01-01

This article reviews the procedure for item response theory (PROC IRT) procedure in SAS/STAT 14.1 to conduct item response theory (IRT) analyses of dichotomous and polytomous datasets that are unidimensional or multidimensional. The review provides an overview of available features, including models, estimation procedures, interfacing, input, and output files. A small-scale simulation study evaluates the IRT model parameter recovery of the PROC IRT procedure. The use of the IRT procedure in Statistical Analysis Software (SAS) may be useful for researchers who frequently utilize SAS for analyses, research, and teaching.

An alternative hypothesis for high-T 40Ar/39Ar age spectrum discordance in polyphase extraterrestrial materials

NASA Astrophysics Data System (ADS)

Cassata, W. S.; Shuster, D. L.; Renne, P. R.; Weiss, B. P.

2009-12-01

A common feature observed in 40Ar/39Ar age spectra of extraterrestrial (ET) rocks is a conspicuous decrease in the ages of high temperature extractions relative to lower temperature steps and a correlated increase in Ca/K, often succeeded by a monotonic increase in ages. This feature is routinely attributed to recoil-implanted 39Ar from a potassium (K)-rich donor phase into a K-poor receptor phase (e.g., 1,2). While 39Ar recoil redistribution is undoubtedly manifested in many terrestrial and ET 40Ar/39Ar whole-rock age spectra, it cannot easily explain the magnitude of high release temperature 40Ar*/39ArK anomalies observed in Martian meteorites ALH 84001 and Nakhla, as well as other course-grained meteorites and lunar rocks. Depending on the aliquot and sample, 50 - 100% of the pyroxene release spectra in ALH 84001 and Nakhla appear strongly perturbed to lower ages. As the mean recoil distance of 39Ar ~0.1 µm, the recoil hypothesis demands that a high-K phase be ubiquitously distributed amongst sub-micron to micron sized pyroxene crystals to account for the observed pyroxene age spectra. However, in both Nakhla and ALH 84001, pyroxene is often completely isolated from high-K phases and individual grains commonly exceed 100 µm in diameter. 40Ar/39Ar analyses of pyroxene-bearing terrestrial basalts, wherein fine-grained pyroxene and plagioclase are intimately adjoined, show that recoil-implanted 39Ar into pyroxene produces much less precipitous anomalies in 40Ar*/39ArK, as predicted by the recoil lengthscale. An alternative hypothesis is that whole-rock age spectra of ET samples with anomalously low ages at high temperatures may reflect diffusive 40Ar distributions within considerably degassed pyroxene grains. Owing to apparent differences in activation energies between glass and/or plagioclase and pyroxene, 40Ar may diffuse more rapidly from pyroxene under certain high-temperature conditions (i.e., above the temperature at which the extrapolated Ar Arrhenius relationships intersect). Thus, very brief, high-temperature shock-heating events may preferentially degas pyroxene without significantly resetting glass and plagioclase 40Ar/39Ar age spectra. This effect would be enhanced by highly localized shock-heating focused along pyroxene (sub)grain boundaries, as has been inferred in other cases (e.g., 3). The shock and impact origin of this feature may explain its frequent appearance in ET samples, regardless of grain size, as well as the general absence of terrestrial analogs. We will present new 40Ar/39Ar data from Martian meteorites and physical models to distinguish between these competing hypotheses. References Cited: 1. Turner & Cadogan, 1974, Possible effects of 39Ar recoil in 40Ar-39Ar dating. Proc. 5th LPSC, 1601- 1615. 2. Huneke & Smith, 1976, The realities of recoil: 39Ar recoil out of small grains and anomalous age patterns in 40Ar-39Ar dating. Proc. 7th LPSC, 1987-2008. 3. Min et al., 2003, Single grain (U-Th)/He ages from phosphates in Acapulco meteorite and implications for thermal history. EPSL 209, 323-336.

Compressive Acceleration of Solar Energetic Particles within Coronal Mass Ejections: Observations and Theory Relevant to the Solar Probe Plus and Solar Orbiter Missions

NASA Astrophysics Data System (ADS)

Roelof, E. C.

2015-12-01

Observations of solar energetic particles (SEPs) over Solar Cycles 22-24 included the measurement of their pitch-angle distributions (PADs). When only magnetically "well-connected" SEP events were selected, i.e., with the spacecraft on interplanetary magnetic field (IMF) lines whose coronal foot-points were within about 30 deg of the associated flare site, the PADs were usually "beam-like" during the rise-to-maximum phase (RTM) of the events. This nearly "scatter-free" propagation (due to magnetic focusing of the IMF) revealed that the injection times of the SEPs were delayed up to 10s of minutes after the onset of electromagnetic emissions from the flare. Direct comparison with the flare-associated coronal mass ejections (CMEs) from the western hemisphere indicated that the SEP acceleration/injection was occurring at least 1 Rs into the corona (and often continuing well above that radial distance). Moreover, the RTM profiles exhibited a continuum of shapes, from "spikes" to "pulses" to "ramps", and these shape characterizations ordered the properties of the associated CMEs. Most importantly, when compared at nearly the same near-relativistic velocities, electrons and protons exhibited similar PADs and RTM profiles. Clearly, such orderly patterns in the data call for a single dominant acceleration process that treats all particles of similar velocities the same, regardless of mass and charge. A simple theory that meets all of these requirements, based on nearly scatter-free propagation and energy change within particle "reservoirs" (such as the closed magnetic structure of a CME), has recently been proposed [Roelof, Proc. 14th Ann. Int'l. Astrophys. Conf., IOP, in press, 2015]. The acceleration results from compression (-divV) of the driver plasma, well sunward of the CME shock. Acceleration (e-folding) times of only a few minutes can be obtained from representative parameters of 1000 km/s CMEs. A companion paper [Roelof and Vourlidas, op. cit.], proposed a new observational technique by which (divV) may be extracted directly from coronograph white-light movies of out-going CMEs, thus offering observational closure of the new theory for SEP acceleration/injection that should be relevant to the Solar Probe Plus and Solar Orbiter missions.

Multireceiver Acoustic Communications in Time-Varying Environments

DTIC Science & Technology

2014-06-01

Canberra, ACT, 2012, pp. 1–7. [7] W. Chen and F. Yanjun, “Physical layer design consideration for underwater acoustic sensor networks ,”3rd IEEE Int...analysis of underwater acoustic MIMO communications,”OCEANS, Sydney, NSW, 2010, pp. 1–8. [9] Wines lab (2013). Wireless networks and embedded... NETWORKS ......................................................................3 B. CHALLENGES OF UNDERWATER ACOUSTIC COMMUNICATIONS

The determination of residence times in a pilot plant

NASA Astrophysics Data System (ADS)

Ramírez, F. Pablo; Cortés, M. Eugenia

2004-01-01

It is well known that residence time distributions (RTD) are very important in many chemical processes such as separation, reforming, hydrocracking, fluid catalytic cracking, hydrodesulfuration, hydrogenation among others [3 Procédés de transformation, Editions Technip, Institute Francais du Petrole, Paris, France, 1998]. In addition, tracers can be used to measure the velocity, distribution and residence time of any stream through any part of an industrial [Guidebook on Radioisotope Tracers in Industry, IAEA, Vienna, 1990] or experimental system. Perhaps the best quality of radiotracers is that they do not interfere with normal unit operations or production scheduling. In this paper are presented the RTDs obtained in a pilot plant for a hydrogenation process [IMP, Technical Report, Determinación del tiempo de residencia promedio en el reactor de la planta piloto de hidroagotamiento de crudo, 2002]. The RTDs show a random phenomenon, which is not typical of this type of chemical processes. Several RTDs were determined in order to confirm this random behavior. The data were obtained using as a tracer a radioactive form of sodium iodide containing iodine-131 [The Condensed Chemical Dictionary, 10th Ed., Van Nostrand Reinhold, USA, 1981]. The process works with two phases in a countercurrent flow, inside a packed column. The liquid phase goes down by gravity. The gas phase goes up due to pressure difference [3 Procédés de transformation, Editions Technip, Institute Francais du Petrole, Paris, France, 1998]. The tracer was selected such that it would follow the liquid phase.

Possiblités de mesure quantitative avec un appareillage de réflectométrie X utilisant le mode angulaire dispersif

NASA Astrophysics Data System (ADS)

Chihab, J.; Naudon, A.

1992-12-01

A normalization procedure for reflectivity curves obtained with a new apparatus using the angle-resolved dispersive mode (J. Appl. Cryst., 1989) is described here. Simulation of spectra with the optical theory of X-rays is then possible. It allows to determine with a good accuracy the density, thickness and interfacial rugosities of layers when their thicknesses are less than about 200 nm. In order to check the normalization procedure a bulk silicon sample and a layer of evaporated nickel are analysed. Dans cet article nous présentons une procédure pour la normalisation des courbes de réflectivité obtenues par un nouvel appareillage de réflectométrie X utilisant le mode angulaire dispersif (J. Appl. Cryst., 1989). La simulation de ces courbes, dans le cadre de la théorie optique, devient alors possible. Pour les dépôts d'épaisseur inférieure à environ 200 nm, elle permet de déterminer précisément l'épaisseur, les rugosités interfaciales et la compacité. Afin de vérifier la validité de notre procédure de normalisation, nous analysons à titre d'exemples le cas d'un échantillon massif de silicium, et celui d'une couche mince de nickel évaporée sur un support en silicium.

Probabilistic Reverse dOsimetry Estimating Exposure Distribution (PROcEED)

EPA Pesticide Factsheets

PROcEED is a web-based application used to conduct probabilistic reverse dosimetry calculations.The tool is used for estimating a distribution of exposure concentrations likely to have produced biomarker concentrations measured in a population.

Settling of abutments into implants and changes in removal torque in five different implant-abutment connections. Part 1: Cyclic loading.

PubMed

Kim, Ki-Seong; Han, Jung-Suk; Lim, Young-Jun

2014-01-01

The aim of this study was to evaluate and compare the settling of abutments into implants and the removal torque values (RTVs) before and after cyclic loading. Five different implant-abutment connections were tested: Ext = external butt joint + two-piece abutment; Int-H2 = internal hexagon + two-piece abutment; Int-H1 = internal hexagon + one-piece abutment; Int-O2 = internal octagon + two-piece abutment; and Int-O1 = internal octagon + one-piece abutment. Ten abutments from each group were secured to their corresponding implants (total n = 50). All samples were tested in a universal testing machine with a vertical load of 250 N for 100,000 cycles of 14 Hz. The amount of settling of the abutment into the implant was calculated from the change in the total length of the implant-abutment sample before and after loading, as measured with an electronic digital micrometer. The RTV after cyclic loading was compared to the initial RTV with a digital torque gauge. Statistical analysis was performed at a 5% significance level. A multiple-comparison test showed specific significant differences in settling values in each group after 250 N cyclic loading (Int-H1, Ext < Int-H2 < Int-O2 < Int-O1). There were statistically significant decreases in RTVs after loading compared to the initial RTVs in the Int-H2 and Int-O2 groups. No statistically significant differences were found in the Ext, Int-H1, and Int-O1 groups. The results of this study demonstrated that the settling amount and RTV (loss of preload) after cyclic loading were specific to the abutment type and related to the design characteristics of the implant-abutment connection.

Detection of genetic association and functional polymorphisms of UGDH affecting milk production trait in Chinese Holstein cattle.

PubMed

Xu, Qing; Mei, Gui; Sun, Dongxiao; Zhang, Qin; Zhang, Yuan; Yin, Cengceng; Chen, Huiyong; Ding, Xiangdong; Liu, Jianfeng

2012-11-02

We previously localized a quantitative trait locus (QTL) on bovine chromosome 6 affecting milk production traits to a 1.5-Mb region between BMS483 and MNB-209 via genome scanning followed by fine mapping. Totally 15 genes were mapped within such linkage region through bioinformatic analysis of the cattle-human comparative map and bovine genome assembly. Of them, the UDP-glucose dehydrogenase (UGDH) was suggested as a potential positional candidate gene for milk production traits based on its corresponding physiological and biochemical functions and genetic effects. By sequencing all the coding exons and the untranslated regions in UGDH with pooled DNA of 8 sires represented the separated families detected in our previous studies, a total of ten SNPs were identified and genotyped in 1417 Holstein cows of 8 separation families. Individual SNP-based association analysis revealed 4 significant associations of SNP Ex1-1, SNP Int3-1, SNP Int5-1, and SNP Ex12-3 with milk yield (P < 0.05), and 2 significant associations of SNP Ex1-1 and SNP Ex12-3 with protein yield (P < 0.05). Furthermore, our haplotype-based association analyses indicated that haplotypes G-C-C, formed by SNP Ex12-2-SNP Int11-1-SNP Ex11-1, T-G, formed by SNP Int9-3-SNP Int9-2, and C-C, formed by SNP Int5-1-SNP Int3-1, are significantly associated with protein percentage (F=4.15; P=0.0418) and fat percentage (F=5.18~7.25; P=0.0072~0.0231). Finally, by using an in vitro expression assay, we demonstrated that the A allele of SNP Ex1-1 and T allele of SNP Ex11-1of UGDH significantly decreases the expression of UGDH by 68.0% at the RNA, and 50.1% at the protein level, suggesting that SNP Ex1-1 and Ex11-1 represent two functional polymorphisms affecting expression of UGDH and may partly contributed to the observed association of the gene with milk production traits in our samples. Taken together, our findings strongly indicate that UGDH gene could be involved in genetic variation underlying the QTL for milk production traits.

Areal Crater Density Analysis of Volcanic Smooth Plains: A New Approach to Distinguishing Age Units

NASA Astrophysics Data System (ADS)

Ostrach, L. R.; Robinson, M. S.

2013-12-01

It is well documented that the lunar maria were emplaced over an extended period of time [e.g., 1-3], and mare units exhibit significant color differences in multispectral data that are interpreted to correlate with distinct mineralogical compositions and ages [e.g., 3-7]. Areal crater density (ACD) analysis is used as a novel approach to identify resurfacing boundaries within Mare Imbrium as a test case for mercurian studies. Absolute model age dating and measures of ACD from crater counts on Lunar Reconnaissance Orbiter Wide Angle Camera (LRO WAC) mosaics reveal two spatially expansive, statistically separable units in Mare Imbrium. The older, spectrally red unit (~15-18 wt% FeO, ~2-5 wt% TiO2 [8]) in the east is ~3.3 Ga, and the younger, spectrally blue unit (~17-20 wt% FeO, ~7-10 wt% TiO2 [8]) in the west is ~2.2 Ga. ACD measurements show a regional boundary at the contact between these two regions. The geologic contact is confidently observed in ACD maps derived for regions with model age differences >300-500 million years and spatial extents >1 × 104 km2. The older, spectrally red unit exhibits higher ACD (>35000 craters with diameters ≥500 m per 106 km2) and the younger, spectrally blue unit has a lower ACD (<26000 craters with diameters ≥500 m per 106 km2); the absolute model ages and ACD results agree with other dating studies of this region [5, 9-12]. Thus, ACD measurements provide a reliable technique to distinguish relative ages among geologic units as well as a means to explore the statistical significance of published absolute model ages. Moreover, the ability to distinguish surface units of different ages from measures of crater frequencies in Mare Imbrium, when spectral information is not available or units do not exhibit spectral contrasts, shows that the ACD technique may be applied to other planetary bodies to search for age boundaries within contiguous smooth plains units. For example, multispectral differences within volcanic units (age and composition) are not observed on Mercury [e.g., 13-15], so the ACD method can be used to test hypotheses concerning timing of smooth plains emplacement [15]. [1] Hartmann W.K. et al. (1981) In: BVTP, 1049-1127. [2] Stöffler D. et al. (2006) Rev. Mineral. Geochem, 60, 519-596. [3] Hiesinger H. et al. (2011) Spec. Pap. - Geol. Soc. Am, 477, 1-51. [4] Pieters C.M. (1978) Proc. Lunar Plan. Sci. Conf, 9th, 2825-2849. [5] Hiesinger H. et al. (2000) J. Geophys. Res, 105, 29239-29275. [6] Staid M.I. and C.M. Pieters (2001) J. Geophys. Res, 106, 27887-27900. [7] Staid M.I. et al. (2011) J. Geophys. Res, 116, E00G10. [8] Lucey P.G. et al. (2000) J. Geophys. Res, 105, 20297-20306. [9] Schaber G.G. (1973) In: Apollo 17 PSR, NASA SP-330, 30-17 to 30-25. [10] Schaber G.G. et al. (1975) The Moon, 13, 395-423. [11] Boyce J.M. and A.L. Dial Jr. (1975) Proc. Lunar Sci. Conf, 6th, 2585-2595. [12] Bugiolacchi R. and J.E. Guest (2008) Icarus, 197, 1-18. [13] Robinson M.S. et al. (2008) Science, 321, 66-69. [14] Denevi B.W. et al. (2009) Science, 324, 613-618. [15] Denevi B.W. et al. (2013) J. Geophys. Res, 118, 1-17.

9. Historic American Buildings Survey Arthur C. Haskell, Photographer Nov. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Historic American Buildings Survey Arthur C. Haskell, Photographer Nov. 2, 1937 (i) INT.- SOUTHEAST WALL, WEST ROOM, 1st. FLOOR - General Joseph Dwight House, U.S. Route 7 & State Route 23, Great Barrington, Berkshire County, MA

The Present Status of the Field of Digital Computer Based Industrial Control Systems and the Work of the International Purdue Workshop in Helping to Promote this Field

DTIC Science & Technology

1978-09-01

Strategy for a Class of Static Systems", IEEE Trans, on Auto. Cont., AC-17, 7-15 (1972). 14. Findeisen , W., and Lefkowitz, I., "Design and Applications...of Multilayer Control", Proc. Fourth IFAC Congress, Warsaw, 1969. 15. Findeisen , W., Multilevel Control Systems, Panstwowe Wydawnictwo Naukowe

The Hermod Behavioral Synthesis System

DTIC Science & Technology

1988-06-08

LDescription 1 lib tech-independent Transformation & Parser Optimization lib Hardware • g - utSynhesze Generator li Datapath lb Hardware liCotllb...Proc. 22nd Design Automation Conference, ACM/IEEE, June 1985, pp. 475-481. [7] G . De Micheli, "Synthesis of Control Systems", in Design Systems for...VLSI Circuits: Logic Synthesis and Silicon Compilation, G . De Micheli, A. Sangiovanni-Vincentelli, and P. Antognetti, (editor), Martinus Nijhoff

Distributed Fusion in Sensor Networks with Information Genealogy

DTIC Science & Technology

2011-06-28

image processing [2], acoustic and speech recognition [3], multitarget tracking [4], distributed fusion [5], and Bayesian inference [6-7]. For...Adaptation for Distant-Talking Speech Recognition." in Proc Acoustics. Speech , and Signal Processing, 2004 |4| Y Bar-Shalom and T 1-. Fortmann...used in speech recognition and other classification applications [8]. But their use in underwater mine classification is limited. In this paper, we

An enhanced Planetary Radar Operating Centre (PROC)

NASA Astrophysics Data System (ADS)

Catallo, C.

2010-12-01

Planetary exploration by means of radar systems, mainly using GPRs is an important role of Italy and numerous scientific international space programs are carried out jointly with ESA and NASA by Italian Space Agency, the scientific community and the industry. Three experiments under Italian leadership ( designed and manufactured by the Italian industry) provided by ASI within a NASA/ESA/ASI joint venture framework are successfully operating: MARSIS on-board MEX, SHARAD on-board MRO and CASSINI Radar on-board Cassini spacecraft: the missions have been further extended . Three dedicated operational centers, namely SHOC, (Sharad Operating Centre), MOC (Marsis Operating Center) and CASSINI PAD are operating from the missions beginning to support all the scientific communities, institutional customers and experiment teams operation Each center is dedicated to a single instrument management and control, data processing and distribution and even if they had been conceived to operate autonomously and independently one from each other, synergies and overlaps have been envisaged leading to the suggestion of a unified center, the Planetary Radar Processing Center (PROC). In order to harmonize operations either from logistics point of view and from HW/SW capabilities point of view PROC is designed and developed for offering improved functionalities to increase capabilities, mainly in terms of data exchange, comparison, interpretation and exploitation. PROC is, therefore, conceived as the Italian support facility to the scientific community for on-going and future Italian planetary exploration programs, such as Europa-Jupiter System Mission (EJSM) The paper describes how the new PROC is designed and developed, to allow SHOC, MOC and CASSINI PAD to operate as before, and to offer improved functionalities to increase capabilities, mainly in terms of data exchange, comparison, interpretation and exploitation aiding scientists to increase their knowledge in the field of surface radar sounding: furthermore the flexibility and the big dimensions of the PROC archives allow easy integration of other missions (e.g. EJSM). A specific PROC Web facility and a dedicated high capacity on line storage allow PROC missions status and scientific results spreading, scientific requests submission, news, studies, technical information, radar data images publication and data retrieving (the latter only on science team members request), according to different permissions assigned both to science team members and generic users

The IntAct molecular interaction database in 2012

PubMed Central

Kerrien, Samuel; Aranda, Bruno; Breuza, Lionel; Bridge, Alan; Broackes-Carter, Fiona; Chen, Carol; Duesbury, Margaret; Dumousseau, Marine; Feuermann, Marc; Hinz, Ursula; Jandrasits, Christine; Jimenez, Rafael C.; Khadake, Jyoti; Mahadevan, Usha; Masson, Patrick; Pedruzzi, Ivo; Pfeiffenberger, Eric; Porras, Pablo; Raghunath, Arathi; Roechert, Bernd; Orchard, Sandra; Hermjakob, Henning

2012-01-01

IntAct is an open-source, open data molecular interaction database populated by data either curated from the literature or from direct data depositions. Two levels of curation are now available within the database, with both IMEx-level annotation and less detailed MIMIx-compatible entries currently supported. As from September 2011, IntAct contains approximately 275 000 curated binary interaction evidences from over 5000 publications. The IntAct website has been improved to enhance the search process and in particular the graphical display of the results. New data download formats are also available, which will facilitate the inclusion of IntAct's data in the Semantic Web. IntAct is an active contributor to the IMEx consortium (http://www.imexconsortium.org). IntAct source code and data are freely available at http://www.ebi.ac.uk/intact. PMID:22121220

RISK CHARACTERIZATION OF DIOXINS

EPA Science Inventory

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD; "Dioxin") is the most toxic member of a family of structurally related compounds which are ubiquitous environmental pollutants. The most potent of these, the polyhalogenated dibenzo-p-dioxins and furans, were never produced int...

Encapsulation and Annealing of Sulfur and Selenium Implanted Gallium Arsenide

DTIC Science & Technology

1978-03-24

Nisse, and F. L. Vook, Plenum Press, New York 1974 (p. 141). 3. J. A. Borders and S. T. Picraux, Proc. IEEE 62, 1224 (1974). 4. A. Hiraki , M. A. Nicolet...and J. W. Mayer, Appl. Phys. Letters 18, 178 (1971). 5. A. Hiraki and E. Lugujjo, J. Vacuum Sci. Technol. 9, 155 (1972). 6. A. Hiraki , E. Lugujjo, M...A. Nicolet, and J. W. Mayer, phys. stat. sol (a) 7, 401 (1971). 7. A. Hiraki , E. Lugujjo, and J. W. Mayer, J. Appl. Phys. 43, 3643 (1972). 8. J. M

Application of Mahler measure theory to the face-centred cubic lattice Green function at the origin and its associated logarithmic integral

NASA Astrophysics Data System (ADS)

Joyce, G. S.

2012-07-01

The mathematical properties of the face-centred cubic lattice Green function \\begin{equation*} \\fl G(w) \\equiv {1\\over {\\pi ^3}}\\int _{0}^{\\pi }\\int _{0}^{\\pi }\\int _{0}^{\\pi } {{d\\theta _1\\,d\\theta _2\\,d\\theta _3}\\over {w-c(\\theta _1)\\,c(\\theta _2)- c(\\theta _2)\\,c(\\theta _3)-c(\\theta _3)\\,c(\\theta _1)}} \\end{equation*} and the associated logarithmic integral \\begin{eqnarray*} \\fl S(w) \\equiv {1\\over {\\pi ^3}}\\int _{0}^{\\pi }\\int _{0}^{\\pi }\\int _{0}^{\\pi } \\ln [ w-c(\\theta _1)\\,c(\\theta _2)-c(\\theta _2)\\,c(\\theta _3)\

The Role of Oxytocin in Social Buffering: What Do Primate Studies Add?

PubMed

Crockford, Catherine; Deschner, Tobias; Wittig, Roman M

2017-09-02

The ability to maintain close social bonds impacts on reproductive success, longevity, stress and health in social mammals, including humans (Silk et al., Curr Biol 20(15):1359-1361, 2010; Crockford et al., Horm Behav 53(1):254-265, 2008; Wittig et al., Horm Behav 54(1):170-177, 2008; Archie et al., Proc R Soc B 281(1793):20141261, 2014; Cameron et al., Proc Natl Acad Sci U S A 106:13850-13853, 2009; Schülke et al., Curr Biol 20:2207-2210, 2010; Silk et al., Science 302:1231-1234, 2003; Holt-Lunstad et al., PLoS Med 7(7):e1000316, 2010). Close social bonds provide an important social support system, at least in part by acting as a buffer against the deleterious effects of chronic exposure to stressors (Young et al., Proc Natl Acad Sci U S A 51:18195-18200, 2014; Heinrichs et al., Biol Psychiatry 54:1389-1398, 2003). There is accumulating evidence that individuals that provide predictable affiliation or support to others (bond partners) may moderate the perception of the stressor as well as of the physiological stress response. The neuropeptide, oxytocin, may mediate social buffering by down-regulating HPA activity and thus reducing the stress response. However, much within this process remains unclear, such as whether oxytocin is always released when exposed to a stressor, whether more oxytocin is released if there is social support, what aspect of stress or social support triggers oxytocin release and whether social support in the absence of a stressor also impacts oxytocin release and HPA activity, during everyday life. We review the literature that addresses each of these questions in an attempt to clarify where future research effort will be helpful. A better understanding of these dynamics is likely to have implications for enhancing social and health gains from human social relationships.

Aerobic Interval Training and Cardiometabolic Health in Patients with Type 2 Diabetes: A Meta-Analysis

PubMed Central

Qiu, Shanhu; Cai, Xue; Sun, Zilin; Zügel, Martina; Steinacker, Jürgen M.; Schumann, Uwe

2017-01-01

Vigorous to maximal aerobic interval training (INT) has received remarkable interest in improving cardiometabolic outcomes for type 2 diabetes patients recently, yet with inconsistent findings. This meta-analysis was aimed to quantify its effectiveness in type 2 diabetes. Randomized controlled trials (RCTs) were identified by searches of 3 databases to October 2017, which evaluated the effects of INT with a minimal training duration of 8 weeks vs. moderate-intensity continuous training (MICT) or non-exercise training (NET) among type 2 diabetes patients on outcomes including cardiorespiratory fitness, glycemic control, body composition, blood pressure, and lipid profiles. Weighted mean differences with 95% confidence intervals (CIs) were calculated with the random-effects model. Nine datasets from 7 RCTs with 189 patients were included. Compared with MICT, INT improved maximal oxygen consumption (VO2max) by 2.60 ml/kg/min (95% CI: 1.32 to 3.88 ml/kg/min, P <0.001) and decreased hemoglobin A1c (HbA1c) by 0.26% (95% CI: −0.46% to −0.07%, P = 0.008). These outcomes for INT were also significant vs. energy expenditure-matched MICT, with VO2max increased by 2.18 ml/kg/min (P = 0.04) and HbA1c decreased by 0.28% (P = 0.01). Yet their magnitudes of changes were larger compared with NET, with VO2max increased by 6.38 ml/kg/min (P <0.001) and HbA1c reduced by 0.83% (P = 0.004). Systolic blood pressure could be lowered by INT compared with energy expenditure-matched MICT or NET (both P <0.05), but other cardiometabolic markers and body composition were not significantly altered in general. In conclusion, despite a limited number of studies, INT improves cardiometabolic health especially for VO2max and HbA1c among patients with type 2 diabetes, and might be considered an alternative to MICT. Yet the optimal training protocols still require to be established. PMID:29218018

The Economic Cost of Implementing Maternal and Neonatal Death Review in a District of Bangladesh.

PubMed

Biswas, Animesh; Halim, Abdul; Rahman, Fazlur; Eriksson, Charli; Dalal, Koustuv

2016-12-09

Maternal and neonatal death review (MNDR) introduced in Bangladesh and initially piloted in a district during 2010. MNDR is able to capture each of the maternal, neonatal deaths and stillbirths from the community and government facilities (hospitals). This study aimed to estimate the cost required to implement MNDR in a district of Bangladesh during 2010-2012. MNDR was implemented in Thakurgaon district in 2010 and later gradually extended until 2015. MNDR implementation framework, guidelines, tools and manual were developed at the national level with national level stakeholders including government health and family planning staff at different cadre for piloting at Thakurgaon. Programme implementation costs were calculated by year of costing and costing as per component of MNDR in 2013. The purchasing power parity conversion rate was 1 $INT = 24.46 BDT, as of 31 st Dec 2012. Overall programme implementation costs required to run MNDR were 109,02,754 BDT (445,738 $INT $INT) in the first year (2010). In the following years cost reduced to 8,208,995 BDT (335,609 $INT, during 2011) and 6,622,166 BDT (270,735 $INT, during 2012). The average cost per activity required was 3070 BDT in 2010, 1887 BDT and 2207 BDT required in 2011 and 2012 respectively. Each death notification cost 4.09 $INT, verbal autopsy cost 8.18 $INT, and social autopsy cost 16.35 $INT. Facility death notification cost 2.04 $INT and facility death review meetings cost 20.44 $INT. One death saved by MNDR costs 53,654 BDT (2193 $INT). Programmatic implementation cost of conducting MPDR give an idea on how much cost will be required to run a death review system for a low income country settings using government health system.

Vertebral Volumetric Bone Density and Strength Are Impaired in Women With Low-Weight and Atypical Anorexia Nervosa

PubMed Central

Bachmann, Katherine N.; Schorr, Melanie; Bruno, Alexander G.; Bredella, Miriam A.; Lawson, Elizabeth A.; Gill, Corey M.; Singhal, Vibha; Meenaghan, Erinne; Gerweck, Anu V.; Slattery, Meghan; Eddy, Kamryn T.; Ebrahimi, Seda; Koman, Stuart L.; Greenblatt, James M.; Keane, Robert J.; Weigel, Thomas; Misra, Madhusmita; Bouxsein, Mary L.; Klibanski, Anne

2017-01-01

Context: Areal bone mineral density (BMD) is lower, particularly at the spine, in low-weight women with anorexia nervosa (AN). However, little is known about vertebral integral volumetric BMD (Int.vBMD) or vertebral strength across the AN weight spectrum, including “atypical” AN [body mass index (BMI) ≥18.5 kg/m2]. Objective: To investigate Int.vBMD and vertebral strength, and their determinants, across the AN weight spectrum Design: Cross-sectional observational study Setting: Clinical research center Participants: 153 women (age 18 to 45): 64 with low-weight AN (BMI <18.5 kg/m2; 58% amenorrheic), 44 with atypical AN (18.5≤BMI<23 kg/m2; 30% amenorrheic), 45 eumenorrheic controls (19.2≤BMI<25 kg/m2). Measures: Int.vBMD and cross-sectional area (CSA) by quantitative computed tomography of L4; estimated vertebral strength (derived from Int.vBMD and CSA) Results: Int.vBMD and estimated vertebral strength were lowest in low-weight AN, intermediate in atypical AN, and highest in controls. CSA did not differ between groups; thus, vertebral strength (calculated using Int.vBMD and CSA) was driven by Int.vBMD. In AN, Int.vBMD and vertebral strength were associated positively with current BMI and nadir lifetime BMI (independent of current BMI). Int.vBMD and vertebral strength were lower in AN with current amenorrhea and longer lifetime amenorrhea duration. Among amenorrheic AN, Int.vBMD and vertebral strength were associated positively with testosterone. Conclusions: Int.vBMD and estimated vertebral strength (driven by Int.vBMD) are impaired across the AN weight spectrum and are associated with low BMI and endocrine dysfunction, both current and previous. Women with atypical AN experience diminished vertebral strength, partially due to prior low-weight and/or amenorrhea. Lack of current low-weight or amenorrhea in atypical AN does not preclude compromise of vertebral strength. PMID:27732336

Vertebral Volumetric Bone Density and Strength Are Impaired in Women With Low-Weight and Atypical Anorexia Nervosa.

PubMed

Bachmann, Katherine N; Schorr, Melanie; Bruno, Alexander G; Bredella, Miriam A; Lawson, Elizabeth A; Gill, Corey M; Singhal, Vibha; Meenaghan, Erinne; Gerweck, Anu V; Slattery, Meghan; Eddy, Kamryn T; Ebrahimi, Seda; Koman, Stuart L; Greenblatt, James M; Keane, Robert J; Weigel, Thomas; Misra, Madhusmita; Bouxsein, Mary L; Klibanski, Anne; Miller, Karen K

2017-01-01

Areal bone mineral density (BMD) is lower, particularly at the spine, in low-weight women with anorexia nervosa (AN). However, little is known about vertebral integral volumetric BMD (Int.vBMD) or vertebral strength across the AN weight spectrum, including "atypical" AN [body mass index (BMI) ≥18.5 kg/m2]. To investigate Int.vBMD and vertebral strength, and their determinants, across the AN weight spectrum. Cross-sectional observational study. Clinical research center. 153 women (age 18 to 45): 64 with low-weight AN (BMI <18.5 kg/m2; 58% amenorrheic), 44 with atypical AN (18.5≤BMI<23 kg/m2; 30% amenorrheic), 45 eumenorrheic controls (19.2≤BMI<25 kg/m2). Int.vBMD and cross-sectional area (CSA) by quantitative computed tomography of L4; estimated vertebral strength (derived from Int.vBMD and CSA). Int.vBMD and estimated vertebral strength were lowest in low-weight AN, intermediate in atypical AN, and highest in controls. CSA did not differ between groups; thus, vertebral strength (calculated using Int.vBMD and CSA) was driven by Int.vBMD. In AN, Int.vBMD and vertebral strength were associated positively with current BMI and nadir lifetime BMI (independent of current BMI). Int.vBMD and vertebral strength were lower in AN with current amenorrhea and longer lifetime amenorrhea duration. Among amenorrheic AN, Int.vBMD and vertebral strength were associated positively with testosterone. Int.vBMD and estimated vertebral strength (driven by Int.vBMD) are impaired across the AN weight spectrum and are associated with low BMI and endocrine dysfunction, both current and previous. Women with atypical AN experience diminished vertebral strength, partially due to prior low-weight and/or amenorrhea. Lack of current low-weight or amenorrhea in atypical AN does not preclude compromise of vertebral strength. Copyright © 2017 by the Endocrine Society

Novel Method for Simultaneous Quantification of Phenotypic Resistance to Maturation, Protease, Reverse Transcriptase, and Integrase HIV Inhibitors Based on 3′Gag(p2/p7/p1/p6)/PR/RT/INT-Recombinant Viruses: a Useful Tool in the Multitarget Era of Antiretroviral Therapy▿†

PubMed Central

Weber, Jan; Vazquez, Ana C.; Winner, Dane; Rose, Justine D.; Wylie, Doug; Rhea, Ariel M.; Henry, Kenneth; Pappas, Jennifer; Wright, Alison; Mohamed, Nizar; Gibson, Richard; Rodriguez, Benigno; Soriano, Vicente; King, Kevin; Arts, Eric J.; Olivo, Paul D.; Quiñones-Mateu, Miguel E.

2011-01-01

Twenty-six antiretroviral drugs (ARVs), targeting five different steps in the life cycle of the human immunodeficiency virus type 1 (HIV-1), have been approved for the treatment of HIV-1 infection. Accordingly, HIV-1 phenotypic assays based on common cloning technology currently employ three, or possibly four, different recombinant viruses. Here, we describe a system to assess HIV-1 resistance to all drugs targeting the three viral enzymes as well as viral assembly using a single patient-derived, chimeric virus. Patient-derived p2-INT (gag-p2/NCp7/p1/p6/pol-PR/RT/IN) products were PCR amplified as a single fragment (3,428 bp) or two overlapping fragments (1,657 bp and 2,002 bp) and then recombined into a vector containing a near-full-length HIV-1 genome with the Saccharomyces cerevisiae uracil biosynthesis gene (URA3) replacing the 3,428 bp p2-INT segment (Dudley et al., Biotechniques 46:458–467, 2009). P2-INT-recombinant viruses were employed in drug susceptibility assays to test the activity of protease (PI), nucleoside/nucleotide reverse transcriptase (NRTI), nonnucleoside reverse transcriptase (NNRTI), and integrase strand-transfer (INSTI) inhibitors. Using a single standardized test (ViralARTS HIV), this new technology permits the rapid and automated quantification of phenotypic resistance for all known and candidate antiretroviral drugs targeting all viral enzymes (PR, RT, including polymerase and RNase H activities, and IN), some of the current and potential assembly inhibitors, and any drug targeting Pol or Gag precursor cleavage sites (relevant for PI and maturation inhibitors) This novel assay may be instrumental (i) in the development and clinical assessment of novel ARV drugs and (ii) to monitor patients failing prior complex treatment regimens. PMID:21628544

3 CFR 102.171-102.999 - [Reserved

Code of Federal Regulations, 2011 CFR

2011-01-01

... Aug. 31 National Wilderness Month, 2010 54455 8554 Sept. 1 National Childhood Obesity Awareness Month...: Establishing a Task Force on Childhood Obesity 7197 Feb. 23 Notice: Continuation of the National Emergency... (Proc. 8578)Childhood Cancer Awareness Month, National (Proc. 8556)Childhood Obesity Awareness Month...

Protein structure refinement using a quantum mechanics-based chemical shielding predictor.

PubMed

Bratholm, Lars A; Jensen, Jan H

2017-03-01

The accurate prediction of protein chemical shifts using a quantum mechanics (QM)-based method has been the subject of intense research for more than 20 years but so far empirical methods for chemical shift prediction have proven more accurate. In this paper we show that a QM-based predictor of a protein backbone and CB chemical shifts (ProCS15, PeerJ , 2016, 3, e1344) is of comparable accuracy to empirical chemical shift predictors after chemical shift-based structural refinement that removes small structural errors. We present a method by which quantum chemistry based predictions of isotropic chemical shielding values (ProCS15) can be used to refine protein structures using Markov Chain Monte Carlo (MCMC) simulations, relating the chemical shielding values to the experimental chemical shifts probabilistically. Two kinds of MCMC structural refinement simulations were performed using force field geometry optimized X-ray structures as starting points: simulated annealing of the starting structure and constant temperature MCMC simulation followed by simulated annealing of a representative ensemble structure. Annealing of the CHARMM structure changes the CA-RMSD by an average of 0.4 Å but lowers the chemical shift RMSD by 1.0 and 0.7 ppm for CA and N. Conformational averaging has a relatively small effect (0.1-0.2 ppm) on the overall agreement with carbon chemical shifts but lowers the error for nitrogen chemical shifts by 0.4 ppm. If an amino acid specific offset is included the ProCS15 predicted chemical shifts have RMSD values relative to experiments that are comparable to popular empirical chemical shift predictors. The annealed representative ensemble structures differ in CA-RMSD relative to the initial structures by an average of 2.0 Å, with >2.0 Å difference for six proteins. In four of the cases, the largest structural differences arise in structurally flexible regions of the protein as determined by NMR, and in the remaining two cases, the large structural change may be due to force field deficiencies. The overall accuracy of the empirical methods are slightly improved by annealing the CHARMM structure with ProCS15, which may suggest that the minor structural changes introduced by ProCS15-based annealing improves the accuracy of the protein structures. Having established that QM-based chemical shift prediction can deliver the same accuracy as empirical shift predictors we hope this can help increase the accuracy of related approaches such as QM/MM or linear scaling approaches or interpreting protein structural dynamics from QM-derived chemical shift.

Tunable Optical Sources.

DTIC Science & Technology

1980-11-01

finite aperture size 5. A. E. Siegman , "Unstable optical resonators for laser of the YAG rod, applications," Proc. IEEE 53, 217-287 (1965); "Unstable...Pumped LiNbO3 Tunable Source Radial Birefringent Element Computer Controlled Laser Attenuator Slab Configuration Laser Source 20. ABSTRACT (Continue on...have invented and demonstrated a computer controlled laser attenu- ator. .... Cont inued DD Il 7 1473 EDITION OF I NOV 01 IS OBSOLETE UNCLASSIFIEDAN

Magnetic Sensors with Picotesla Magnetic Field Sensitivity at Room Temperature

DTIC Science & Technology

2008-06-01

such small fields require cryogenic cooling such as SQUID sensors, require sophisticated detection systems such as atomic magnetometers and fluxgate ... magnetometers , or have large size and poor low frequency performance such as coil systems. [3-7] The minimum detectable field (the field noise times...Kingdon, "Development of a Combined EMI/ Magnetometer Sensor for UXO Detection," Proc. Symposium on the Applications of Geophysics to Environmental and

The Shock and Vibration Digest. Volume 14, Number 7

DTIC Science & Technology

1982-07-01

Yang, ed., pp 93-107, 13 figs, 4 refs Key Words: Tube arrays. Heat exchangers . Wind tunnel testing . Critical speeds. Fluid-induced excitation...the Eighties," Proc. Const. Indus. Res. Inform. Assoc. Conf., Lon- don, UK (Nov 1980). 38 BOOK REVIEWS FLOW-INDUCED HEAT EXCHANGER TUBE...1980 Heat exchanger problems caused by flow-induced vibration are of concern to designers and operators of heat exchangers . Flow-induced vibration

Study of application rates of aerosol and pump hair sprays. Final report, July 1986-November 1987

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boggs, R.R.; Belmont, B.

Application rates of three hair spray dispensing systems, aerosol, pump, and Exxel packaging were determined through a six-week user panel of approximately 300 people. In addition, photochemically reactive organic compounds (PROC) application rates were determined through chemical analysis of the products. The user panel was stratified on the basis of sex, dispenser (pump/aerosol), and age (adult/teen). Weighted-application rates and weighted PROC application rates are included. A Mann-Whitney evaluation was made to evaluate differences between data sets. Product-usage data for both male and female adult groups support the conclusion that increased use of either pumps or Exxel packaging for hair spraymore » would reduce PROC emissions in California. Data from adult groups also indicate that use of Exxel packaging in place of pumps would not reduce PROC. Consumer preference was also sampled. Adult pump users were not very willing to switch to aerosols, but on the order of half of aerosol users were willing to switch to pumps.« less

Automated Extraction and Characterisation of Social Network Data from Unstructured Sources -- An Ontology-Based Approach

DTIC Science & Technology

2013-06-01

o provide da ocessed to e alyst can sea mation, it jus g the results e this, the SN iting for new  is  download  be modified  define  the  p xpression...ste y carving ou various steps n a notificati gies  from th logies of inte r  use  is  simi n refer to c s a generic    i.e.,  if  the  the quality a...on  the ust take  into ata  model a f the same d otype provid cument. The acts about th  in figure 4,  platform po always hold  xception  is  f fact

Diffusivity in Alumina Scales Grown on Al-MAX Phases

NASA Technical Reports Server (NTRS)

Smialek, James L.

2014-01-01

Ti3AlC2, Ti2AlC, and Cr2AlC are oxidation resistant MAX phase compounds distinguished by the formation of protective Al2O3 scales with well controlled kinetics. A modified Wagner treatment was used to obtain interfacial grain boundary diffusivity, deltaD(sub gb,O,int.), from scale growth rates and corresponding grain size. It is based on the p(O2)(exp -1/6) dependency of the double charged oxygen vacancy and oxygen diffusivity, coupled with the effective diffusion constant for short circuit grain boundary paths. Data from the literature for MAX phases was analyzed accordingly, and deltaD(sub gb,O,int.) was found to nearly coincide with the Arrhenius line developed for Zr-doped FeCrAl, where: deltaD(sub gb,O,int.) = 1.8x10(exp -10) exp(-375 kJ/RT) cubic meters/s. Furthermore, this oxidation relation suggests the more general format applicable to bulk samples under ambient conditions: deltaD(sub gb,O) = 7.567x10(exp -8) exp(-544 kJ/RT) p(O2)(exp -1/6) cubic meters/[s x Pa(exp -1/6)]. Data from many other FeCrAl(X) studies were similarly assessed to show general agreement with the relation for deltaD(sub gb,O,int.). This analysis reinforces the view that protective alumina scales grow by similar mechanisms for these Al-MAX phases and oxidation resistant FeCrAl alloys.

Hospital admissions by the oldest old: Past trends in one of the most ageing countries in the world.

PubMed

Brandão, Daniela; Ribeiro, Oscar; Freitas, Alberto; Paúl, Constança

2017-11-01

To examine discharges of octogenarians, nonagenarians and centenarians from Portuguese public hospitals, namely admission type, principal diagnoses, comorbidities and length of stay. The present study used administrative data from public acute care hospitals in the Portuguese National Health Service. All discharges of persons aged ≥80 years between 2000 and 2014 were analyzed. HCUP Clinical Classifications Software was considered to aggregate principal diagnosis, and comorbidities were assessed using the Charlson Comorbidity Index computed using International Classification of Diseases 9th Revision Clinical Modification codes. A total of 2 494 924 discharges of persons aged 80 years or older were registered. Most (73.7%) referred to inpatient episodes, of which 73% were unplanned and medical (non-surgical). Pneumonia (12.2%), acute cerebrovascular disease (7.1%) and non-hypertensive cardiac heart failure (5.3%) were the most common principal diagnoses among inpatient episodes. Congestive heart failure and diabetes without chronic complications were the two most frequent comorbidities (16.6%), and discharge diagnoses with higher median length of stay were tuberculosis, burns, and infective arthritis and osteomyelitis. The number of hospitalizations of the oldest old has suffered a significant increase in the past few years, reinforcing the need for healthcare services being prepared to the specificities of the oldest old population. Geriatr Gerontol Int 2017; 17: 2255-2265. © 2017 Japan Geriatrics Society.

Xq28 duplication overlapping the int22h-1/int22h-2 region and including RAB39B and CLIC2 in a family with intellectual and developmental disability.

PubMed

Andersen, Erica F; Baldwin, Erin E; Ellingwood, Sara; Smith, Rosemarie; Lamb, Allen N

2014-07-01

Duplications involving terminal Xq28 are a known cause of intellectual disability (ID) in males and in females with unfavorable X-inactivation patterns. Within Xq28, functional disomy of MECP2 causes a severe ID syndrome, however the dosage sensitivity of other Xq28 duplicated genes is less certain. Duplications involving the int22h-1/int22h-2 LCR-flanked region in distal Xq28 have recently been linked to a novel ID-associated phenotype. While evidence for the dosage sensitivity of this region is emerging, the phenotypic contribution of individual genes within the int22h-1/int22h-2-flanked region has yet to be determined. We report a familial case of a novel 774 kb Xq28-qter duplication, detected by cytogenomic microarray analysis, that partially overlaps the int22h-1/int22h-2-flanked region. This duplication and a 570 kb Xpter-p22.33 loss within the pseudoautosomal region were identified in three siblings, one female and two males, who presented with developmental delays/intellectual disability, mild dysmorphic features and short stature. Although unconfirmed, these results are suggestive of maternal inheritance of a recombinant X. We compare our clinical findings to patients with int22h-1/int22h-2-mediated duplications and discuss the potential pathogenicity of genes within the duplicated region, including those within the shared region of overlap, RAB39B and CLIC2. © 2014 Wiley Periodicals, Inc.

Conversion efficiency limits and bandgap designs for multi-junction solar cells with internal radiative efficiencies below unity.

PubMed

Zhu, Lin; Mochizuki, Toshimitsu; Yoshita, Masahiro; Chen, Shaoqiang; Kim, Changsu; Akiyama, Hidefumi; Kanemitsu, Yoshihiko

2016-05-16

We calculated the conversion-efficiency limit ηsc and the optimized subcell bandgap energies of 1 to 5 junction solar cells without and with intermediate reflectors under 1-sun AM1.5G and 1000-sun AM1.5D irradiations, particularly including the impact of internal radiative efficiency (ηint) below unity for realistic subcell materials on the basis of an extended detailed-balance theory. We found that the conversion-efficiency limit ηsc significantly drops when the geometric mean ηint* of all subcell ηint in the stack reduces from 1 to 0.1, and that ηsc degrades linearly to logηint* for ηint* below 0.1. For ηint*<0.1 differences in ηsc due to additional intermediate reflectors became very small if all subcells are optically thick for sun light. We obtained characteristic optimized bandgap energies, which reflect both ηint* decrease and AM1.5 spectral gaps. These results provide realistic efficiency targets and design principles.

Human Infrastructure & Human Activity Detection

DTIC Science & Technology

2007-07-01

Personnel Detection Using Seismic Sensors”, Proc. of SPIE, Vol. 5090, 2003, pp. 162-173. [3] J. M. Cathcart , “Phenomenological investigations into...personnel signatures,” Proc. of the SPIE, Vol. 5796, pp. 428-434, May 2005. [4] B. Mauro & J. M. Cathcart , “Analysis of visible band sensors for

UAS-NAS Live Virtual Constructive Distributed Environment (LVC): LVC Gateway, Gateway Toolbox, Gateway Data Logger (GDL), SaaProc Software Design Description

NASA Technical Reports Server (NTRS)

Jovic, Srboljub

2015-01-01

This document provides the software design description for the two core software components, the LVC Gateway, the LVC Gateway Toolbox, and two participants, the LVC Gateway Data Logger and the SAA Processor (SaaProc).

Greater India

NASA Astrophysics Data System (ADS)

Ali, Jason R.; Aitchison, Jonathan C.

2005-10-01

"Greater India" is an 80-yr-old concept that has been used by geoscientists in plate tectonic models of the India-Asia collision system. Numerous authors working on the orogen and/or plate models of the broader region have added various sized chunks of continental lithosphere to the now northern edge of their reconstructed Indian plate. Prior to plate tectonic theory, Emile Argand (1924) [Argand, E., 1924. La tectonique de l' Asie. Proc. 13th Int. Geol. Cong. 7 (1924), 171-372.] and Arthur Holmes (1965) [Holmes, A., 1965. Principles of Physical Geology, Second Edition. The Ronald Press Company, New York, 1128.] thought that the Himalayan Mountains and Tibetan Plateau had been raised due to the northern edge of the Indian craton under-thrusting the entire region. Since the advent of plate tectonic theory, Greater India proposals have been based principally on three lines of logic. One group of workers has added various amounts of continental lithosphere to India as part of their Mesozoic Gondwana models. A second form of reconstruction is based on Himalayan crustal-shortening estimates. A third body of researchers has used India continent extensions as means of allowing initial contact between the block and the Eurasian backstop plate in southern Tibet to take place at various times between the Late Cretaceous and late Eocene in what we call "fill-the-gap" solutions. The Indian craton and the southern edge of Eurasia were almost invariably some distance from one another when the collision was supposed to have started; extensions to the sub-continent were used to circumvent the problem. Occasionally, Greater India extensions have been based on a combination of fill-the-gap and shortening estimate arguments. In this paper, we exhume and re-examine the key Greater India proposals. From our analysis, it is clear that many proponents have ignored key information regarding the sub-continent's pre break-up position within Gondwana and the bathymetry of the Indian Ocean west of Australia, in particular the Wallaby-Zenith Plateau Ridge and the Wallaby-Zenith Fracture Zone. We suggest that the Indian continent probably extended no more than 950 km in the central portion of the Main Boundary Thrust, up to the Wallaby-Zenith Fracture Zone. At the Western Syntaxis, the extension was about 600 km. These estimates are broadly compatible with some of the geophysically-derived models depicting subducted Indian lithosphere beneath Tibet, as well as estimates of Himalayan shortening. Models requiring sub-continent extensions > 9° ahead of the craton are probably wrong. We also suggest that northern India did not have a thinned rifted passive margin due to the earlier rifting of blocks away from it when it formed part of Gondwana. Instead, the boundary developed as a transform fault and probably had a very narrow ocean-continent transition zone (5-10 km wide), similar to the Romanche Fracture Zone offshore of Ghana, West Africa.

Dietary and Environmental Exposure to Cadmium and the Risk of Breast Cancer

DTIC Science & Technology

2011-10-01

feeding history, oral contraceptive use or hormone replacement therapy. There was little difference between urinary Cd concentrations based on...Flemish adolescents and adults: associations and dose- response relationships. Environ Int, 2010, 36:330-7. Ikeda, M. , Moriguchi, J. , Ezaki, T

Effect of pH, sodium chloride and sodium pyrophosphate on the termal resistance of Escherichia coli O157:H7 in ground beef

USDA-ARS?s Scientific Manuscript database

Response to the Letter to the Editor: We have received with great satisfaction that our article “Modelling the effect of pH, sodium chloride and sodium pyrophosphate on the thermal resistance of Escherichia coli O157:H7 in ground beef” (Food Research International, 69:289-304; 2015) has awaken inte...

VizieR Online Data Catalog: Redshifts of galaxies in Abell 1351 field (Barrena+, 2014)

NASA Astrophysics Data System (ADS)

Barrena, R.; Girardi, M.; Boschin, W.; de Grandi, S.; Rossetti, M.

2015-03-01

Multi-object spectroscopic (MOS) observations of A1351 were carried out at the TNG on 2010 March 10. We used DOLORES/MOS with the LR-B Grism 1, yielding a dispersion of 187Å/mm. We used the 2048x2048 pixel E2V CCD, with a pixel size of 13.5um. In total, we observed four MOS masks including 143 slits. For each mask, the exposure time was 3x1800s. We had already observed A1351 field with the Wide Field Camera (WFC), mounted at the prime focus of the 2.5m INT telescope. We took exposures of 9x600s and 9x300s in B and R Harris filters in photometric conditions and 1.2-arcsec seeing. However, we used SDSS-DR7 data because a greater number of photometric bands are available, which allows an accurate colour analysis. INT and SDSS-DR7 photometric data are very similar. The completeness magnitude is r'=20.8. (1 data file).

Low Phase Noise Fiber Optics Links for Space Applications

DTIC Science & Technology

2005-07-13

photo- oscillateur intégré pour 17 dB de pertes optiques Liaison active à 874,2 MHz avec photo- oscillateur intégré pour 18 dB de pertes optiques Liaison...active à 874,2 MHz avec photo- oscillateur intégré pour 20 dB de pertes optiques Liaison active à 874,2 MHz avec photo- oscillateur intégré pour 23 dB...de pertes optiques Liaison active à 874,2 MHz avec photo- oscillateur intégré pour 25 dB de pertes optiques Liaison active à 874,2 MHz avec photo

CALL FOR PAPERS: 13th International Conference on Force and Mass Measurement

NASA Astrophysics Data System (ADS)

1992-01-01

10 14 May 1993, Helsinki Fair Centre, Finland Scope of the Conference The Conference reports and reviews the state of the art and future trends in force and mass measurements in science and industry. Emphasis is on the applications of new methods, current problems in calibration and quality control, as well as on advancements in new sensor technologies and industrial application of force and mass measurements. Main Themes and Topics 1. The state of the art and development trends in force and mass measurements Development and stability of high level mass standards Mass comparators and force standard machine New research topics in mass and force 2. Calibration and quality control Calibration methods Estimation of uncertainties and classification of accuracies Relations between calibration, testing and quality control Requirements for quality control Verification of weighing instruments and their main devices 3. Application of force and mass measurements Automatic weighing Mass flow measurements Quality control in process industry Sensor technologies Practical applications Special applications in industry, trade, etc. Deadline for submission of abstracts: 30 June 1992. For further information please contact: Finnish Society of Automation, Asemapäällikönkatu 12C, SF-00520 HELSINKI, Finland Phone: Int. +3580 1461 644, Fax: Int. +3580 1461 650

A Cluster-Randomized, Community-Based, Tribally Delivered Oral Health Promotion Trial in Navajo Head Start Children.

PubMed

Braun, P A; Quissell, D O; Henderson, W G; Bryant, L L; Gregorich, S E; George, C; Toledo, N; Cudeii, D; Smith, V; Johs, N; Cheng, J; Rasmussen, M; Cheng, N F; Santo, W; Batliner, T; Wilson, A; Brega, A; Roan, R; Lind, K; Tiwari, T; Shain, S; Schaffer, G; Harper, M; Manson, S M; Albino, J

2016-10-01

The authors tested the effectiveness of a community-based, tribally delivered oral health promotion (OHP) intervention (INT) at reducing caries increment in Navajo children attending Head Start. In a 3-y cluster-randomized trial, we developed an OHP INT with Navajo input that was delivered by trained Navajo lay health workers to children attending 52 Navajo Head Start classrooms (26 INT, 26 usual care [UC]). The INT was designed as a highly personalized set of oral health-focused interactions (5 for children and 4 for parents), along with 4 fluoride varnish applications delivered in Head Start during academic years of 2011 to 2012 and 2012 to 2013. The authors evaluated INT impact on decayed, missing, and filled tooth surfaces (dmfs) increment compared with UC. Other outcomes included caries prevalence and caregiver oral health-related knowledge and behaviors. Modified intention-to-treat and per-protocol analyses were conducted. The authors enrolled 1,016 caregiver-child dyads. Baseline mean dmfs/caries prevalence equaled 19.9/86.5% for the INT group and 22.8/90.1% for the UC group, respectively. INT adherence was 53% (i.e., ≥3 child OHP events, ≥1 caregiver OHP events, and ≥3 fluoride varnish). After 3 y, dmfs increased in both groups (+12.9 INT vs. +10.8 UC; P = 0.216), as did caries prevalence (86.5% to 96.6% INT vs. 90.1% to 98.2% UC; P = 0.808) in a modified intention-to-treat analysis of 897 caregiver-child dyads receiving 1 y of INT. Caregiver oral health knowledge scores improved in both groups (75.1% to 81.2% INT vs. 73.6% to 79.5% UC; P = 0.369). Caregiver oral health behavior scores improved more rapidly in the INT group versus the UC group (P = 0.006). The dmfs increment was smaller among adherent INT children (+8.9) than among UC children (+10.8; P = 0.028) in a per-protocol analysis. In conclusion, the severity of dental disease in Navajo Head Start children is extreme and difficult to improve. The authors argue that successful approaches to prevention may require even more highly personalized approaches shaped by cultural perspectives and attentive to the social determinants of oral health (ClinicalTrials.gov NCT01116739). © International & American Associations for Dental Research 2016.

Pursuit, Avoidance, and Cohesion in Flight: Multi-Purpose Control Laws and Neuromorphic VLSI

DTIC Science & Technology

2010-10-01

34 Binaural Spectral Cues for Ultrasonic Localization," Proc. International Symposium on Circuits and Systems, pp. 2110 - 2113, 2008 (DOI:10.1109/ISCAS...T. K. Horiuchi, C. Bansal, and T. M. Massoud (2009), " Binaural Intensity Comparison in the Echolocating Bat Using Synaptic Conductance," Proc

Using Continuous Voice Recognition Technology as an Input Medium to the Naval Warfare Interactive Simulation System (NWISS).

DTIC Science & Technology

1984-06-01

Co ,u’arataor, Gr 7- / ’ . c ; / , caae.ic >ar. ’ ’# d:.i II ’ ..... .. . . .. .. . ... . , rV ABSTRACT A great d-al of research has been conducted an...9 2. Continuous Voice -%ecoait.ior, ....... 11 B. VERBEX 3000 SPEECH APPLiCATION DEVELOP !ENT SYSTEM! ( SPADS ...13 C . NAVAL IAR FARE INT7EACTI7E S:AIULATIC"N SYSTEM (NWISS) ....... .................. 14 D. PURPOSE .................... 16 1. A Past

Sensitive fluorescent in situ hybridisation method for the characterisation of breast cancer cells in bone marrow aspirates.

PubMed Central

Forus, A; Høifødt, H K; Overli, G E; Myklebost, O; Fodstad, O

1999-01-01

AIM: The presence of malignant cells in the blood and bone marrow of patients with cancer at the time of surgery may be indicative of early relapse. In addition to their numbers, the phenotypes of the micrometastatic cells might be essential in determining whether overt metastases will develop. This study aimed to establish a sensitive method for the detection and characterisation of malignant cells present in bone marrow. METHODS: In spiking experiments, SKBR3 cells were mixed with mononuclear cells in known proportions to mimic bone marrow samples with micrometastatic cells. Tumour cells were extracted using SAM-M450 Dynabeads coupled to the MOC-31 anti-epithelial antibody, and were further analysed for amplification of erbB2 and int2 by fluorescent in situ hybridisation (FISH). erbB2 and int2 copy numbers were also determined in 15 primary breast cancers, and bone marrow samples from patients with amplification were analysed for micrometastatic cells by immunomagnetic enrichment and FISH. RESULTS: In model experiments, cells with amplification could be detected in bead selected fractions when ratios of tumour cells (SKBR3) to mononuclear cells were as low as 10:10(7). Among the tumour samples, eight showed increased copy numbers of erbB2 and/or int2, and three of these patients had detectable numbers of tumour cells in their bone marrow: 4000, 540, and 26 tumour cells/10(7) mononuclear cells, respectively. The patient with 540 tumour cells/10(7) mononuclear cells showed high level amplification of erbB2 and suffered from a particularly aggressive disease, whereas the patient with 4000 tumour cells/10(7) mononuclear cells had favourable disease progression. CONCLUSION: These results demonstrate the feasibility and advantage of combining immunomagnetic selection and FISH characterisation of cancer cells in bone marrow samples. It is possible that molecular characterisation of such cells could provide prognostically valuable information. PMID:10474684

The economic burden of self-reported and undiagnosed cardiovascular diseases and diabetes on Indonesian households.

PubMed

Finkelstein, Eric A; Chay, Junxing; Bajpai, Shailendra

2014-01-01

The goal of this study is: (1) to estimate the current direct out-of-pocket (OOP) and indirect non-communicable diseases (NCD) burden on Indonesian households and (2) to project NCD prevalence and burden in 2020 focusing specifically on hypertension, diabetes, heart problems and stroke. This study relies on econometric analyses based on four waves of the Indonesian Family Life Survey (IFLS). In aggregate, of the NCDs studied, heart problems exert the greatest economic burden on households, costing Int$1.56 billion in OOP and indirect burden in 2010. This was followed by hypertension (Int$1.36 billion), diabetes (Int$0.81 billion) and stroke (Int$0.29 billion). The OOP and indirect burden of these conditions is estimated to be Int$4.02 billion. Diabetes and stroke are expected to have the largest proportional increases in burden by 2020; 56.0% for diabetes and 56.9% for stroke to total Int$1.27 billion and Int$0.45 billion respectively. The burden of heart problems in 2020 is expected to increase by 34.4% to total Int$2.09 billion and hypertension burden will increase by 46.1% to Int$1.99 billion. In 2020, these conditions are expected to impose an economic burden of Int$5.80 billion. In conclusion, this study demonstrates the significant burden of 4 primary NCDs on Indonesian households. In addition to the indirect burden, hypertension, diabetes, heart problems and stroke account for 8% of the nation's OOP healthcare expenditure, and due to rising disease prevalence and an aging population, this figure is expected to increase to 12% by 2020 without a significant health intervention.

Characterization of IntA, a Bidirectional Site-Specific Recombinase Required for Conjugative Transfer of the Symbiotic Plasmid of Rhizobium etli CFN42

PubMed Central

Hernández-Tamayo, Rogelio; Sohlenkamp, Christian; Puente, José Luis; Brom, Susana

2013-01-01

Site-specific recombination occurs at short specific sequences, mediated by the cognate recombinases. IntA is a recombinase from Rhizobium etli CFN42 and belongs to the tyrosine recombinase family. It allows cointegration of plasmid p42a and the symbiotic plasmid via site-specific recombination between attachment regions (attA and attD) located in each replicon. Cointegration is needed for conjugative transfer of the symbiotic plasmid. To characterize this system, two plasmids harboring the corresponding attachment sites and intA were constructed. Introduction of these plasmids into R. etli revealed IntA-dependent recombination events occurring at high frequency. Interestingly, IntA promotes not only integration, but also excision events, albeit at a lower frequency. Thus, R. etli IntA appears to be a bidirectional recombinase. IntA was purified and used to set up electrophoretic mobility shift assays with linear fragments containing attA and attD. IntA-dependent retarded complexes were observed only with fragments containing either attA or attD. Specific retarded complexes, as well as normal in vivo recombination abilities, were seen even in derivatives harboring only a minimal attachment region (comprising the 5-bp central region flanked by 9- to 11-bp inverted repeats). DNase I-footprinting assays with IntA revealed specific protection of these zones. Mutations that disrupt the integrity of the 9- to 11-bp inverted repeats abolish both specific binding and recombination ability, while mutations in the 5-bp central region severely reduce both binding and recombination. These results show that IntA is a bidirectional recombinase that binds to att regions without requiring neighboring sequences as enhancers of recombination. PMID:23935046

The ECRH/ECCD system on Tore Supra, a major step towards continuous operation

NASA Astrophysics Data System (ADS)

Lennholm, M.; Agarici, G.; Berger-By, G.; Bosia, P.; Bouquey, F.; Cellier, E.; Clary, J.; Clapit, M.; Darbos, C.; Giruzzi, G.; Jung, M.; Magne, R.; Roux, D.; Segui, J. L.; Traisnel, E.; Zou, X.

2003-11-01

The 118 GHz electron cyclotron heating and current drive (ECRH/ECCD) system under development in Cadarache, France, for use on the Tore Supra tokamak (Pain M. et al 1994 Proc. 18th SOFT (Karlsruhe) pp 481 4: Darbos C. et al 2000 Proc. 21st SOFT (Madrid) pp 605 9), is designed to launch 2.4 MW of power for up to 10 min into the plasma. At present two out of six gyrotrons are installed and available for injection of up to 800 kW. This paper concentrates on the generation and transmission of the ECRH/ECCD power for very long pulse operation. The power is injected into the plasma as Gaussian beams by an antenna which, using actively cooled mirrors inside the Tore Supra vacuum vessel, allows extensive control of both the poloidal and toroidal injection angles. The toroidal field on Tore Supra is normally in the range of 3.8 4 T, which for 118 GHz gives almost central deposition at the fundamental electron cyclotron resonance. A pair of actively cooled corrugated mirrors is installed in each matching optics unit at the output of each gyrotron allowing complete control of the polarization of the wave transmitted to the antenna, with the result that pure O-mode—or pure X-mode—power injection can be achieved for all injection angles. In tokamak experiments, a world record energy of 17.8 MJ has been injected into the plasma. New upgraded gyrotrons specified to produce 400 kW for up to 10 min will be introduced over the next 3 4 years.

Increasing heat storage by wearing extra clothing during upper body exercise up-regulates heat shock protein 70 but does not modify the cytokine response.

PubMed

Leicht, Christof A; Papanagopoulos, Aris; Haghighat, Sam; Faulkner, Steve H

2017-09-01

Plasma heat shock protein 70 (HSP70) concentrations rise during heat stress, which can independently induce cytokine production. Upper body exercise normally results in modest body temperature elevations. The aim of this study was to investigate the impacts of additional clothing on the body temperature, cytokine and HSP70 responses during this exercise modality. Thirteen males performed 45-min constant-load arm cranking at 63% maximum aerobic power (62 ± 7%V̇O 2peak ) in either a non-permeable whole-body suit (intervention, INT) or shorts and T-shirt (control, CON). Exercise resulted in a significant increase of IL-6 and IL-1ra plasma concentrations (P < 0.001), with no difference between conditions (P > 0.19). The increase in HSP70 from pre to post was only significant for INT (0.12 ± 0.11ng∙mL -1 , P < 0.01 vs. 0.04 ± 0.18 ng∙mL -1 , P = 0.77). Immediately following exercise, T core was elevated by 0.46 ± 0.29 (INT) and 0.37 ± 0.23ºC (CON), respectively (P < 0.01), with no difference between conditions (P = 0.16). The rise in mean T skin (2.88 ± 0.50 and 0.30 ± 0.89ºC, respectively) and maximum heat storage (3.24 ± 1.08 and 1.20 ± 1.04 J∙g -1 , respectively) was higher during INT (P < 0.01). Despite large differences in heat storage between conditions, the HSP70 elevations during INT, even though significant, were very modest. Possibly, the T core elevations were too low to induce a more pronounced HSP70 response to ultimately affect cytokine production.

Ricardo Oliveira | NREL

Science.gov Websites

the System Modeling & Geospatial Data Science Group in the Strategic Energy Analysis Center. Areas Publications Oliveira, R and Moreno, R. 2016. Harvesting, Integrating and Distributing Large Open Geospatial Datasets Using Free and Open-Source Software. Int. Arch. Photogramm. Remote Sens. Spatial Inf. Sci., XLI-B7

Development of Analysis Tools for Certification of Flight Control Laws

DTIC Science & Technology

2009-03-31

In Proc. Conf. on Decision and Control, pages 881-886, Bahamas, 2004. [7] G. Chesi, A. Garulli, A. Tesi , and A. Vicino. LMI-based computation of...Minneapolis, MN, 2006, pp. 117-122. [10] G. Chesi, A. Garulli, A. Tesi . and A. Vicino, "LMI-based computation of optimal quadratic Lyapunov functions...Convex Optimization. Cambridge Univ. Press. Chesi, G., A. Garulli, A. Tesi and A. Vicino (2005). LMI-based computation of optimal quadratic Lyapunov

Effect of Contact Damage on the Strength of Ceramic Materials.

DTIC Science & Technology

1982-10-01

variables that are important to erosion, and a multivariate , linear regression analysis is used to fit the data to the dimensional analysis. The...of Equations 7 and 8 by a multivariable regression analysis (room tem- perature data) Exponent Regression Standard error Computed coefficient of...1980) 593. WEAVER, Proc. Brit. Ceram. Soc. 22 (1973) 125. 39. P. W. BRIDGMAN, "Dimensional Analaysis ", (Yale 18. R. W. RICE, S. W. FREIMAN and P. F

Automatic/Control Processing and Attention.

DTIC Science & Technology

1982-04-01

changes that occur with practice have lead many researchers to propose that qualitative changes occur in the processing (e.g., James, 1890; LaBerge ...functions are similar. Perception & Psychophvsics, 1972, 12, 378-3G4. (b) March 26, 19C2 Page 22 LaBerge , D. Acquisition of automatic processing in... LaBerge & S. J. Samuels (Eds.), Lasic Proc7’-.es in reading: Perception and comprehension. Hillsdale, N.J.: Schneider, W., & Shiffrin, R. M

Role of p53 in Mammary Epithelial Cell Senescence

DTIC Science & Technology

2009-05-01

Cellular Senescence and Skin Aging . In Skin Aging Handbook: Market Perspectives, Pharmacology, Formulation, and Evaluation Techniques, ed., N. Dayan...identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A, 1995. 92(20): p. 9363-7. 12. Dimri, G.P., et al...NIH): ZAI1- BDP- I(J2), RFA-AI-08-012 ( Rejuvenating the Aged Immune System) 2009: Online Reviewer USAMRMC BCRP Concept

Thermal-Polarimetric and Visible Data Collection for Face Recognition

DTIC Science & Technology

2016-09-01

pixels • Spectral range: 7.5–13 μm • Analog image output: NTSC analog video • Digital image output: Firewire radiometric, 14-bit digital video to...PC The analog video was not used for this study. The radiometric, 14-bit digital data provided temperature measurement information for comparison...distribution unlimited. 18 9. References 1. Choi J, Hu S, Young SS, Davis LS. Thermal to visible face recognition. Proc. SPIE 8371, Sensing

Tip-over Prevention Through Heuristic Reactive Behaviors for Unmanned Ground Vehicles

DTIC Science & Technology

2014-05-01

Systems Center Pacific Unmanned Systems Group 53406 Woodward Road San Diego, CA 92152 ABSTRACT Skid-steer teleoperated robots are commonly used by...Reactive Behaviors Further author information: (Send correspondence to K.T.) K.T.: E-mail: kurt.talke@navy.mil, SPIE Proc. 9084: Unmanned Systems ...5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Space and Naval Warfare Systems Center

Optical Processing.

DTIC Science & Technology

1985-12-31

34 Optics Letters, 2 (1), 1-3 (1978). 7. Grossberg, S., "Adaptive Resonance in Development, Perception and Cognition ," SIAM-AMS Proc., 13, 107-156...Illusions," Biol. Cybernetics, 23, 187-202, (1976b). 11. Grossberg, S., "How Does A Brain Build a Cognitive Code?", Psychol. Review, 87 (1), 1-51 (1980...34perceptron" (F. Rosenblatt, Principles of Neurodynamics ), workers in the neural network field have been seeking to understand how neural networks can perform

Classificaiton and Discrimination of Sources with Time-Varying Frequency and Spatial Spectra

DTIC Science & Technology

2007-04-01

sensitivity enhancement by impulse noise excision," in Proc. IEEE Nat. Radar Conf., pp. 252-256, 1997. [7] M. Turley, " Impulse noise rejection in HF...specific time-frequency points or regions, where one or more signals reside, enhances signal-to- noise ratio (SNR) and allows source discrimination and...source separation. The proposed algorithm is developed assuming deterministic signals with additive white complex Gaussian noise . 6. Estimation of FM

The Mechanism of Blood Function and Production After Injury.

DTIC Science & Technology

1980-02-01

radioactive 59Fe labeled red cell dilution method described by Garcia7 . Red cell 2,3 diphosphoglycerate levels were measured using a commercial kit...and protein depleted rats was also associated with elevated 2,3 diphosphoglycerate levels (p<.05)(Table IV) suggesting partial compensation for anemic...Brewer, G.J.: The relationship between red cell 2,3 diphosphoglycerate and levels of hemoglobin in the human. Proc.Soc. Exp.Biol.Med. 150(1): 215-9

VizieR Online Data Catalog: 100-Mpc-scale structures of radio galaxies (Brand+, 2003)

NASA Astrophysics Data System (ADS)

Brand, K.; Rawlings, S.; Hill, G. J.; Lacy, M.; Mitchell, E.; Tufts, J.

2003-09-01

The TONS08 survey is in one of the areas covered by the 7CRS (Willott et al., 2002MNRAS.335.1120W) and the TexOx-1000 (TOOT) survey (Hill & Rawlings, 2002, ASP Conf. Proc., Leiden. Astron. Soc. Pac., San Francisco). It covers the region 08h 10m 20s <= RA <= 08h 29m 20s and 24{deg} 10' 00" <= DE<= 29{deg} 30' 00" (J2000). Unlike the low-frequency-selected 7CRS and TOOT, the TONS08 survey is selected at 1.4GHz from the NVSS. (1 data file).

Performance Sustainment of Two Man Crews During 87 Hours of Extended Wakefulness With Stimulants (Dexedrine, Caffeine, Modafinil) and Napping: Analysis of Aircrew Performance During In-Flight Emergency Situations

DTIC Science & Technology

2008-05-01

BQs ) (see Appendix B for a listing of CCOs and BQs ). The grading guidance provided direction in determining performance on a scale of 1 to 7 (table...THU FRI SAT In-Proc./ Training/ Baseline/ Testing 1/ Testing 2/ Testing 3/ Recovery/ Day 1 Day 2 Day 3 Day 4 Day 5 Day 6 Day 7 00:00 Sleep Sleep...Checklist For use of this form, see ACT Aircrew Guide CCO BQ Crew Coordination Objectives/Basic Qualities Rating I Establish and Maintain Team Relationships

Asymptotic expressions for turbulent burning velocity at the leading edge of a premixed flame brush and their validation by published measurement data

NASA Astrophysics Data System (ADS)

Lee, Jaeseo; Lee, Gwang G.; Huh, Kang Y.

2014-12-01

This paper presents validation of new analytical expressions for the turbulent burning velocity, ST, based on asymptotic behavior at the leading edge (LE) in turbulent premixed combustion. Reaction and density variation are assumed to be negligible at the LE to avoid the cold boundary difficulty in the statistically steady state. Good agreement is shown for the slopes, dST/du', with respect to Lc/δf at low turbulence, with both normalized by those of the reference cases. δf is the inverse of the maximum gradient of reaction progress variable through an unstretched laminar flame, and Lc is the characteristic length scale given as burner diameter or measured integral length scale. Comparison is made for thirty-five datasets involving different fuels, equivalence ratios, H2 fractions in fuel, pressures, and integral length scales from eight references [R. C. Aldredge et al., "Premixed-flame propagation in turbulent Taylor-Couette flow," Combust. Flame 115, 395 (1998); M. Lawes et al., "The turbulent burning velocity of iso-octane/air mixtures," Combust. Flame 159, 1949 (2012); H. Kido et al., "Influence of local flame displacement velocity on turbulent burning velocity," Proc. Combust. Inst. 29, 1855 (2002); J. Wang et al., "Correlation of turbulent burning velocity for syngas/air mixtures at high pressure up to 1.0 MPa," Exp. Therm. Fluid Sci. 50, 90 (2013); H. Kobayashi et al., "Experimental study on general correlation of turbulent burning velocity at high pressure," Proc. Combust. Inst. 27, 941 (1998); C. W. Chiu et al., "High-pressure hydrogen/carbon monoxide syngas turbulent burning velocities measured at constant turbulent Reynolds numbers," Int. J. Hydrogen Energy 37, 10935 (2012); P. Venkateswaran et al., "Pressure and fuel effects on turbulent consumption speeds of H2/CO blends," Proc. Combust. Inst. 34, 1527 (2013); M. Fairweather et al., "Turbulent burning rates of methane and methane-hydrogen mixtures," Combust. Flame 156, 780 (2009)]. The turbulent burning velocity is shown to increase as the flamelet thickness, δf, decreases at a high pressure, for an equivalence ratio slightly rich or close to stoichiometric and for mixture of a high H2 fraction. Two constants involved are C to scale turbulent diffusivity as a product of turbulent intensity and characteristic length scale and Cs to relate δf with the mean effective Lm. L m = (D m u / SL u 0) is the scale of exponential decay at the LE of an unstretched laminar flame. The combined constant, KC/Cs, is adjusted to match measured turbulent burning velocities at low turbulence in each of the eight different experimental setups. All measured S T / SL u 0 values follow the line, KDtu/Dmu + 1, at low turbulent intensities and show bending below the line due to positive mean curvature and broadened flamelet thickness at high turbulent intensities. Further work is required to determine the constants, Cs and K, and the factor, (L m / Lm * - L m (∇ ṡ n) f), that is responsible for bending in different conditions of laminar flamelet and incoming turbulence.

Evidence of human-induced morphodynamic changes along the Campania coastal areas (southern Italy) since the 3rd-4th cent. AD

NASA Astrophysics Data System (ADS)

Russo Ermolli, Elda; Romano, Paola; Liuzza, Viviana; Amato, Vincenzo; Ruello, Maria Rosaria; Di Donato, Valentino

2014-05-01

Campania has always offered suitable climatic and physiographic conditions for human settlements since prehistoric times. In particular, many Graeco-Roman towns developed along its coasts starting from the 7th-6th cent. BC. In the last decade, geoarchaelogical surveys have been carried out in the archaeological excavations of Neapolis, Paestum and Elea-Velia allowing the main steps of the landscape evolution around these towns to be defined in detail. The greek town of Neapolis rose in the late 6th cent. BC [1] on a terrace overlooking a low-relief rocky coast surrounded by volcanic hills. Port activities developed in a protected bay facing the town from the 4th-2nd cent. BC up to the 4th cent. AD, as testified by the discovery of structures and shipwrecks [2, 3, 4]. Starting from the 3rd cent. AD a spit bar formed at the bay entrance causing the progressive establishment of a lagoon which was gradually filled up by alluvial inputs and completely closed in the 5th cent. AD. During the same period, episodes of increased alluvial inputs were also recorded further west along the coast, where a narrow sandy beach formed at the cliff toe. The greek town of Poseidonia, renamed Paestum by the Romans, was founded in the 540 BC on a travertine terrace facing the sandy littoral of a prograding coastal plain [5]. In front of the main town door, a coastal lagoon developed thanks to the growth of a dune ridge and was probably used for harbor activities [5]. After this period the shoreline shifted seawards, another dune ridge formed and the back-ridge depression was filled with fluvial-marshy deposits, slowly drying up. Phases of travertine deposition, which characterized the SE sector of the plain all along the Holocene, were recorded in the northern and southern quarters of the town in historical times and were connected to the abandonment of the town in the early Medieval times. The greek colony of Elea-Velia was located on top of a siliciclastic promontory where the ruins of the first archaic settlement (late 6th cent. BC) was unearthed. The Graeco-Roman town expanded downhill, exploiting the growth of a coastal plain, where occasional phases of flooding coexisted with the life of the citizens [6]. The onset of the 3rd cent. AD was characterized by phases of extreme floods which also occurred during the 4th and 5th cent. AD leading to several meters of ground-level aggradation and the burial of buildings [6, 7]. Although the three investigated sites are located in rather different morphological context, they show the evidence of a disequilibrium in the morphodynamics which started in the 3rd-4th cent. AD. The vast amount of collected data strongly suggest that this disequilibrium is a clear sign of a socio-economic decline which affected the Roman Empire during this period rather than the consequence of a climatic deterioration towards dryer conditions, for which no detailed data are available in the Mediterranean area [8]. The abandonment of the towns and their surroundings triggered increased soil erosion on the slopes suffering deforestation and in the farmlands for reduced maintenance, enhancing accumulation rates at the foothills and along coastal areas. References [1] D'Agostino, B., Giampaola, D., 2005. Osservazioni storiche e archeologiche sulla fondazione di Neapolis, in: Harris, W.V., Lo Cascio, E. (Eds.), Noctes Campanae, studi di storia antica e archeologia dell'Italia pre-romana e romana in memoria di Martin W. Frederiksen, Napoli, 63-72. [2] Giampaola, D., Carsana, V., Boetto, G., Bartolini, M., Capretti, C., Galotta, G., Giachi, G., Macchioni, N., Nugari, M. P., Pizzo, B., 2006. La scoperta del porto di Neapolis: dalla ricostruzione topografica allo scavo e al recupero dei relitti. Arch. Mar. Medit., Int. J. Underwat. Arch. 2, 47-91, Ist. Ed. Poligr.Int. MMVI, Pisa - Roma. [3] Allevato, E., Russo Ermolli, E., Boetto, G., Di Pasquale, G., 2010. Pollen-wood analysis at the Neapolis harbour site (1st-3rd century AD, southern Italy) and its archaeobotanical implications. J. Archaeol. Sci. 37, 2365-2375. [4] Russo Ermolli E., Romano P., Ruello M.R., Barone Lumaga M.R, in press. The natural and cultural landscape of Naples (southern Italy) during the Graeco-Roman and Late Antique periods. J. Archaeol. Sci. [5] Amato, V., Aucelli, P.,D'Argenio, B., Da Prato, S., Ferraro, L., Pappone, G., Petrosino, P., Rosskopf, C.M., Russo Ermolli, E., 2012. Holocene environmental evolution of the coastal sector before the Poseidonia-Paestum archaeological area (Sele plain, southern Italy). Rend. Fis. Acc. Lincei. doi:10.1007/s12210-011-0161-1 [6] Amato V., Bisogno G., Cicala L., Cinque A., Romano P., Ruello MR., Russo Ermolli E., 2010. Palaeo-environmental changes in the archaeological settlement of Elea-Velia: climatic and/or human impact signatures? In Ciarallo A., Senatore M.R. (2010) Scienze naturali ed archeologia. Il paesaggio antico: interazione uomo/ambiente ed eventi catastrofici. Aracne Editrice, Roma, pag 13-16. ISBN 978-88-548-3525-2 [7] Russo Ermolli E., Romano P., Ruello M.R., 2013. Human-environment interactions in the southern Tyrrhenian coastal area: hypothesis from Neapolis and Elea-Velia. In: Harris W.V. (Ed.) The ancient Mediterranean environment between science and history Columbia Studies in the Classical Tradition 39, BRILL Leiden-Boston, ISBN 978-90-04-25343-8, pp. 213-232. [8] Büntgen, U., Tegel, W., Nicolussi, K., McCormick, M., Frank, D., Trouet, V., Kaplan, J.O., Herzig, F., Heussner, K-U., Wanner, H., Luterbacher, J., Esper, J., 2011. 2500 Years of European Climate Variability and Human Susceptibility. Science 331, 578-582.

Modification of hectorite by organofunctionalization for use in removing U(VI) from aqueous media: thermodynamic approach.

PubMed

Guerra, Denis L; Airoldi, Claudio; Viana, Rúbia R

2010-02-01

A Hectorite sample (H) has been chemically modified with N-propyldiethylenetrimethoxysilane and bis[3-(triethoxysilyl)propyl]tetrasulfide. The resulting materials (H(3TPT) and H(NPTM)) have been characterized through elemental analysis, X-ray diffractometry, carbon nuclear magnetic resonance in the solid state, textural analysis, and thermogravimetric analysis. The adsorption experiments were performed under batch process with pH, ionic strength, contact time, and uranyl concentration as variables. The attached basic centers adsorbed uranyl cation to give maxima adsorption capacity of 5.55+/-0.21, 14.86+/-0.05, and 18.99+/-0.05 x 10(-3) mmol g(-1) for H, H(3TPT), and H(NPTM), respectively. From calorimetric determinations the quantitative thermal effects for UO(2)(2+)/center interactions gave exothermic enthalpy (Delta(int)H=-6.90 to -7.88 kJ mol(-1)), negative Gibbs free energy (Delta(int)G=-22.34 to -24.56 kJ mol(-1)), and positive entropy (Delta(int)S=51.80-56.00 JK(-1)mol(-1)). These thermodynamic data confirmed the energetically favorable condition of such interaction solid/liquid for all systems. Copyright 2009. Published by Elsevier Ltd.

Predicting Database Requirements for Geographic Information Systems in the Year 2000: Long-Term Design Issues for GRASS

DTIC Science & Technology

1992-08-01

Image Processing. Reading, Massachusetts: Addison-Wesley (1977). Graefe, G., "Parallelizing the Volcano Query Processor," Proc. IEEE COMPCON 90...Approach to a Next Generation of Hypermedia System," Proc. IEEE COMPCON 90 (February 1990), pp 520-527. Jellinghaus, R., " Eiffel Linda: An Object

Performance Evaluation of Multihop Packet Radio Networks by Simulation

DTIC Science & Technology

1987-03-01

Multihop Packet Radio Networks," Proc. IEEE, Vol. 75, No. 1, January 1987. [15] 1. Gitman , "On the Capacity of Slotted ALOHA Networks and Some Design...Networks in the Presence of Noise," Proc. Infocom, Washington D. C., April 1985 [40] H. Frank, I. Gitman and R. Van Slyke, " Packet Radio System

Evaluation of Low-volume Sprayers Used in Asian Citrus Psyllid Control Applications

DTIC Science & Technology

2010-06-01

control, p. 149–157. In: B. Aubert, S. Tontyaporn, and D. Buangsuwon (eds.). Proc. Asia Pacific Intl. Conf. Citriculture, Chiang Mai , Thailand, 4–10...planning and management, p. 77–82. In: B. Aubert, S. Tontyaporn, and D. Buangsuwon (eds.). Proc. Asia Pacific Intl. Conf. Citriculture, Chiang Mai , Thailand

Recent Advances In Radar Polarimetry And Polarimetric SAR Interferometry

DTIC Science & Technology

2007-02-01

Workshop, ESA SERRÍN, Frascati, Italy, January 2003. [69] EUSAR 2000 Procs, VDE Verlag, Offenbach, ISBN: 3-8007-2544-4, Munich, Germany, May 2000. [70...EUSAR 2002 Procs, VDE Verlag, Offenbach, ISBN: 3-8007-2697-1, Cologne, Germany, June 2002. [71] Ferro-Famil, L. and E. Pottier, 2000, "Description of

Detection of Explosives on Surfaces Using UV Raman Spectroscopy: Effect of Substrate Color

DTIC Science & Technology

2017-10-01

Jr, editors. Proc. SPIE 5794; Detection and Remediation Technologies for Mines and Minelike Targets X; 2005; Orlando, FL. Bellingham (WA): Society of...detection of 2,4-DNT in contact with sand particles. In: Harmon RS, Broach JT, Holloway JH Jr, editors. Proc. SPIE 6217; Detection and Remediation

Study of the efficacy of aerosol versus nonaerosol laundry products. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boggs, R.R.; Belmont, B.

1987-10-01

The California Air Resources Board estimates that 6.6 tons of photochemically reactive organic compounds (PROC) are released into the environment in California every day because of the use of aerosol laundry products. The project studied the efficacy, ease of product use, and PROC content for three major brands of pre-wash stain removers in available product forms and for five starch products in their available product forms. Efficacy of pre-wash products was generally found to be limited. They were particularly useful for oil and ball point ink removal. Aerosols were found to be slightly superior. PROC content varied from 16-76% onmore » aerosols; none was found in nonaerosols. Aerosols were found to be slightly easier to use by the laboratory investigator. For starches, on synthetic fabrics Faultless aerosol was found to be superior. For natural fabrics, results were mixed. Efficacy per unit cost was found to be high for bulk starches. PROC content for the two aerosols was 5.8% for Faultless and 8.5% for Niagra. Aerosols were easiest to use and bulk products rather difficult to use.« less

Using SAS PROC CALIS to fit Level-1 error covariance structures of latent growth models.

PubMed

Ding, Cherng G; Jane, Ten-Der

2012-09-01

In the present article, we demonstrates the use of SAS PROC CALIS to fit various types of Level-1 error covariance structures of latent growth models (LGM). Advantages of the SEM approach, on which PROC CALIS is based, include the capabilities of modeling the change over time for latent constructs, measured by multiple indicators; embedding LGM into a larger latent variable model; incorporating measurement models for latent predictors; and better assessing model fit and the flexibility in specifying error covariance structures. The strength of PROC CALIS is always accompanied with technical coding work, which needs to be specifically addressed. We provide a tutorial on the SAS syntax for modeling the growth of a manifest variable and the growth of a latent construct, focusing the documentation on the specification of Level-1 error covariance structures. Illustrations are conducted with the data generated from two given latent growth models. The coding provided is helpful when the growth model has been well determined and the Level-1 error covariance structure is to be identified.

Relationships between sulfachloropyridazine sodium, zinc, and sulfonamide resistance genes during the anaerobic digestion of swine manure.

PubMed

Zhang, Ranran; Gu, Jie; Wang, Xiaojuan; Qian, Xun; Duan, Manli; Sun, Wei; Zhang, Yajun; Li, Haichao; Li, Yang

2017-02-01

In this study, swine manure containing sulfachloropyridazine sodium (SCPS) and zinc was subjected to mesophilic (37°C) anaerobic digestion (AD). The absolute abundances (AAs) of antibiotic resistance genes (ARGs) were evaluated, as well as intI1 and intI2, and the degradation of SCPS according to variation in the amount of bio-available zinc (bio-Zn). In digester that only contained SCPS, the concentrations of SCPS were lower than that digesters both contain SCPS and Zn. Compared with the control digester, the addition of SCPS increased the AAs of sul1, sul3, drfA1, and drfA7 by 1.3-13.1 times. However, compared with the digester with SCPS but no added Zn, the AAs of sul3, drfA1, and drfA7 were decreased by 21.4-70.3% in the presence of SCPS and Zn, whereas sul1 and sul2 increased 1.3-10.7 times. There were significant positive correlations (P<0.05) between the concentrations of SCPS with several ARGs and bio-Zn. Copyright © 2016. Published by Elsevier Ltd.

Failure Wave in DEDF and Soda-Lime Glass During Rod Impact

NASA Astrophysics Data System (ADS)

Orphal, Dennis; Behner, Thilo; Anderson, Charles; Templeton, Douglas

2005-07-01

Investigations of glass by planar, and classical and symmetric Taylor impact experiments reveal that failure wave velocity U/F depends on impact velocity, geometry, and the type of glass. U/F typically increases with impact velocity to between ˜ 1.4 C/S and C/L (shear and longitudinal wave velocities, respectively). This paper reports the results of direct high-speed photographic measurements of the failure wave for gold rod impact from 1.2 and 2.0 km/s on DEDF glass (C/S = 2.0, C/L =3.5 km/s). The average rod penetration velocity, u, was measured using flash X-rays. Gold rods eliminated penetrator strength effects. U/F for gold rod impact on DEDF is ˜ 1.0-1.2 km/s, which is considerably less than C/S. The increase of u with impact velocity is greater than that of U/F. These results are confirmed by soda-lime glass impact on a gold rod at an impact velocity of 1300 m/s. Similar results are found in``edge-on-impact'' tests; U/F values of 1.4 km/s and 2.4-2.6 km/s in soda-lime glass are reported for W-alloy rod impact, considerably less than C/S (3.2 km/s) [1,2]. [1] Bless, et. al.(1990) AIP Proc. Shock Comp. Cond. Matter---1989, pp. 939-942 (1990) [2] E. L. Zilberbrand, et. al. (1999) Int. J. Impact Engng., 23, 995-1001 (1999).

Modelling the Contributions of Malaria, HIV, Malnutrition and Rainfall to the Decline in Paediatric Invasive Non-typhoidal Salmonella Disease in Malawi.

PubMed

Feasey, Nicholas A; Everett, Dean; Faragher, E Brian; Roca-Feltrer, Arantxa; Kang'ombe, Arthur; Denis, Brigitte; Kerac, Marko; Molyneux, Elizabeth; Molyneux, Malcolm; Jahn, Andreas; Gordon, Melita A; Heyderman, Robert S

2015-01-01

Nontyphoidal Salmonellae (NTS) are responsible for a huge burden of bloodstream infection in Sub-Saharan African children. Recent reports of a decline in invasive NTS (iNTS) disease from Kenya and The Gambia have emphasised an association with malaria control. Following a similar decline in iNTS disease in Malawi, we have used 9 years of continuous longitudinal data to model the interrelationships between iNTS disease, malaria, HIV and malnutrition. Trends in monthly numbers of childhood iNTS disease presenting at Queen's Hospital, Blantyre, Malawi from 2002 to 2010 were reviewed in the context of longitudinal monthly data describing malaria slide-positivity among paediatric febrile admissions, paediatric HIV prevalence, nutritional rehabilitation unit admissions and monthly rainfall over the same 9 years, using structural equation models (SEM). Analysis of 3,105 iNTS episodes identified from 49,093 blood cultures, showed an 11.8% annual decline in iNTS (p < 0.001). SEM analysis produced a stable model with good fit, revealing direct and statistically significant seasonal effects of malaria and malnutrition on the prevalence of iNTS disease. When these data were smoothed to eliminate seasonal cyclic changes, these associations remained strong and there were additional significant effects of HIV prevalence. These data suggest that the overall decline in iNTS disease observed in Malawi is attributable to multiple public health interventions leading to reductions in malaria, HIV and acute malnutrition. Understanding the impacts of public health programmes on iNTS disease is essential to plan and evaluate interventions.

Antibiotic resistance genes and intI1 prevalence in a swine wastewater treatment plant and correlation with metal resistance, bacterial community and wastewater parameters.

PubMed

Yuan, Qing-Bin; Zhai, Yi-Fan; Mao, Bu-Yun; Hu, Nan

2018-06-07

The livestock wastewater treatment plant represents an important reservoir of antibiotic resistance determinants in the environment. The study explored the prevalence of five antibiotic resistance genes (ARGs, including sulI, tetA, qnrD, mphB and mcr-1) and class 1 integron (intI1) in a typical livestock wastewater treatment plant, and analyzed their integrated association with two metal resistance genes (copA and czcA), two pathogens genes (Staphylococcus and Campylobacter), bacterial community and wastewater properties. Results indicated that all investigated genes were detected in the plant. The treatment plant could not completely remove ARGs abundances, with up to 2.2 × 10 4 ~3.7 × 10 8 copies/L of them remaining in the effluent. Mcr-1 was further enriched by 27-fold in the subsequent pond. The correlation analysis showed that mphB significantly correlateed with tetA and intI. Mcr-1 strongly correlated with copA. MphB and intI significantly correlated with czcA. The correlations implied a potential co-selection risk of bacterial resistant to antibiotics and metals. Redundancy analyses indicated that qnrD and mcr-1 strongly correlated with 13 and 14 bacterial genera, respectively. Most ARGs positively correlated to wastewater nutrients, indicating that an efficient reduction of wastewater nutrients would contribute to the antibiotic resistance control. The study will provide useful implications on fates and reductions of ARGs in livestock facilities and receiving environments. Copyright © 2018. Published by Elsevier Inc.

Determination of metabolic profile of anti-malarial trioxane CDRI 99/411 in rat liver microsomes using HPLC.

PubMed

Mishra, Smriti; Manickavasagam, Lakshmi; Jain, Girish Kumar

2012-01-01

CDRI 99/411 is a potent 1,2,4-trioxane anti-malarial candidate compound of the Central Drug Research Institute, India. This study aimed to conduct comprehensive in vitro metabolic investigations of CDRI 99/411 to corroborate its preclinical investigations. Preliminary in vitro metabolic investigations were performed to assess the metabolic stability [in vitro half-life (t(1/2) ) and in vitro hepatic intrinsic clearance (Cl(int) )] of CDRI 99/411 in male Sprague-Dawley rat and human liver microsomes using validated high-performance liquid chromatography with photodiode array detector. The observed in vitro t(1/2) of the compound in rat and human liver microsomes was 13 min with in vitro Cl(int) 130.7±25.0 μL/min/mg and 19 min with in vitro Cl(int) 89.3 ± 17.40 μL/min/mg. These observations suggested moderate metabolic degradation and in vitro Cl(int) with insignificant difference (p>0.05) in the metabolic stability profile in rat and human. Hence, in vitro metabolic investigations were performed with rat liver microsomes. It was observed that CDRI 99/411 exhibited sigmoidal kinetics. At nonlinear regression (r ≥ 0.99) EC(50) and Hill slope values were 17 µm and 1.50, respectively. The metabolism of CDRI 99/411 was primarily mediated by CYP3A2 and was inferred by CYP reaction phenotyping with known potent inhibitors. Two metabolites of CDRI 99/411 were detected which were undetectable on incubation with 1-aminobenzotriazole and ketoconazole. Copyright © 2011 John Wiley & Sons, Ltd.

Canadian Thesis Abstracts: Synthèse spectrale de jeunes populations stellaires dans; l'ultraviolet lointain

NASA Astrophysics Data System (ADS)

Pellerin, Anne

2005-02-01

Le but de cette thèse était de développer et tester la technique de synthè;se spectrale évolutive aux longueurs d'onde de l'ultraviolet lointain. Jusquà récemment, cette technique n'était appliqué quà des données au-delà de 1200 Å. Le lancement du satellite FUSE en 1999 a permis d'explorer le domaine de l'ultraviolet lointain (900-1200 Å) avec une grande résolution spectrale. J'ai donc utilisé les spectres du satellite FUSE de 228 étoiles chaudes de type O et B, de 24 galaxies à sursauts de formation d'étoiles et de quatre galaxies Seyfert. Dans un premier temps, j'ai caractérisé le comportement des profils de raies stellaires en fonction du type spectral, de la classe de luminosité et de la métallicité des étoiles. Les raies O vi >>1031.9, 1037.6, S iv >>1062.7, 1073.0, 1073.5, P v>>1118.0, 1128.0 et C iii >1175.6 ont été identifiées comme étant des indicateurs stellaires potentiellement intéressants pour la synthèse spectrale. Le domaine de longueur d'onde inférieur à 1000 Å couvert par FUSEmontre aussi des signatures stellaires mais qui sont peu intéressantes pour la synthèse en raison de la contamination interstellaire. J'ai ensuite crééé; une bibliothèque de spectres FUSE qui a été intégrée au code de synthèse LavalSBafin de produire des spectres de synthèse dans l'ultraviolet lointain pour diverses populations stellaires théoriques. Il s'est avéré que les raies de P vet de C iii sont d'excellents indicateurs d'âge, de métallicité et de fonction de masse initiale de la population stellaire, tandis que les raies de O vi et de S ivne sont pas aussi efficaces. La comparaison des spectres FUSEde galaxies avec les spectres synthétiques a révèlé des âges entre 2.5 et 18 millions d'années pour un large éventail de métallicités. On trouve aussi une forte dominance du mode instantané de formation stellaire. Ce travail a aussi permis d'estimer quantitativement l'extinction interne et les masses stellaires impliquées dans les sursauts. La synthèse des raies de l'ultraviolet lointain s'est avérée beaucoup plus précise que la synthèse à > 1200 Å en raison de la résolution spectrale exceptionnelle de FUSE et parce que les raies stellaires n'ont pas de profils saturés, même aux métallicités élevées. Les propriétés physiques globales des 24 galaxies à sursauts ont aussi été étudiées dans leur ensemble afin de mieux décrire le phénomène des sursauts de formation stellaires.

Etude des connaissances, attitudes et pratiques en matière de réintégration sociale des femmes victimes de fistule obstétricale: région de l'Extrême-nord, Cameroun

PubMed Central

Martin, Sanou Sobze; Adogaye, Sali Ben Béchir; Rodrigue, Mabvouna Biguioh; Maurice, Douryang; Vivaldi, Teikeu Tessa Vladimir; Amede, Saah Fopa Michael; Marie, Ovaga Eyenga Landry; Meriam, Ausseil Sandra; Colizzi, Vittorio; Gianluca, Russo

2015-01-01

Introduction La fistule obstétricale est un orifice entre le vagin et la vessie ou le rectum, voire les deux. Ses impacts sont des conséquences anatomo-fonctionnelles et sociales. On estime à plus de 19 000 le nombre de femmes qui souffrent de fistule obstétricale au Cameroun. Méthodes Il s'agissait d'une étude transversale descriptive conduite dans trois districts de santé de la région de l'Extrême-nord. Vingt-huit femmes victimes de fistules obstétricales, quarante-deux membres de leur entourage et vingt-quatre agents de santé ont été interviewés entre Novembre et Décembre 2013. Trois types de questionnaires ont été utilisés. Les données ont été analysées dans Epi Info version 7.1.4.0. Les moyennes et les fréquences ont été calculées avec un intervalle de confiance à 95%. Résultats 46,4% des femmes victimes de fistule obstétricales interviewées avaient subi une intervention chirurgicale réparatrice parmi lesquelles, 61,5% bénéficiaient de la réintégration. Le fonds de commerce (62,5%) était l'aide la plus reçue. Vingt-deux membres de l'entourage savaient pourquoi on fait la réintégration. Selon eux, les considérations socioculturelles (68,2%), sont la principale barrière de la réintégration. D'après les agents de santé, le suivi psychosocial (58,3%) est la principale activité de la réintégration dans les centres de prise en charge de la fistule. Conclusion La prise en charge des fistules obstétricales au Cameroun souffre de manque de réintégration sociale. Ceci expliquerait en partie la persistance de cette pathologie. Un accent devrait être mis sur l'appui matériel, financier et sur le suivi psychosocial des femmes victimes de fistule obstétricale. PMID:26113915

ISALE impact simulations in support of AIDA mission

NASA Astrophysics Data System (ADS)

Oklay, Nilda; Vincent, Jean-Baptiste; Michel, Patrick; Schwartz, Stephen

2016-07-01

Introduction: The Asteroid Impact Deflection Assessment (AIDA) mission is a joint project of ESA and NASA with two independent spacecraft. ESA's contribution is an observer satellite called Asteroid Impact Mission (AIM, [1]), and NASA's contribution is a projectile called Double Asteroid Redirection Test (DART, [2]). The target of the mission is a near-Earth binary asteroid system (65803) Didymos. The aim is to study the possibility of deflecting an asteroid by using a kinetic impactor, as well as to characterize the internal properties of the target and test various relevant technologies for other missions. The design is that the DART would impact the secondary of the binary system and AIM would characterize the target asteroid, observe the impact event and measure the changes in the relative orbit after the impact. Impact modeling will be used to interpret the results of the AIDA impact event. There are numerous impact simulation codes, which are planned to be used to understand the AIDA impact results. Therefore an international benchmarking program is ongoing for the comparison of the results of various codes on the defined test cases [3]. We will present the results of the test cases performed by iSALE hydrocode. Modeling: In this work we use the iSALE-2D shock physics code [4], which is based on the SALE hydrocode solution algorithm [5]. To simulate hypervelocity impact processes in solid materials SALE was modified to include an elastoplastic constitutive model, fragmentation models, various EOS, and multiple materials [6, 7]. More recent improvements include a modified strength model [8] and a porosity compaction model [4, 9]. References: [1] Michel P. et al., 2016, ASR, submitted [2] Cheng A. F. et al., (2016) PSS, 121, 27-35 [3] Stickle A. M. et al., (2016). 47th LPSC [4] Wünnemann,K. et al., (2006). Icarus, 180:514-527 [5] Amsden, A., et al., (1980) LANL Report, LA-8095:101p. [6] Melosh, H. J., et al., (1992). J. Geophys. Res., 97(E9):14735-14759 [7] Ivanov, B. A., et al., (1997) Int. J. Imp. Eng., 20:411-430; [8] Collins, G. S., et al., (2004). Met. & Planet. Sci., 39:217-231. [9] Collins, G., et al., (2011) Int. J. Imp. Eng., 38:434-439

Gene-Environment Interplay in Internalizing Disorders: Consistent Findings across Six Environmental Risk Factors

PubMed Central

Hicks, Brian M.; DiRago, Ana C.; Iacono, William G.; McGue, Matt

2009-01-01

Background Newer behavior genetic methods can better elucidate gene-environment (G-E) interplay in the development of internalizing (INT) disorders (i.e., major depression and anxiety disorders). However, no study to date has conducted a comprehensive analysis examining multiple environmental risks with the purpose of delineating how general G-E mechanisms influence the development of INT disorders. Methods The sample consisted of 1315 male and female twin pairs participating in the age 17 assessment of the Minnesota Twin Family Study. Quantitative G-E interplay models were used to examine how genetic and environmental risk for INT disorders changes as a function of environmental context. Multiple measures and informants were employed to construct composite measures of INT disorders and 6 environmental risk factors including: stressful life events, mother-child and father-child relationship problems, antisocial and prosocial peer affiliation, and academic achievement and engagement. Results Significant moderation effects were detected between each environmental risk factor and INT such that in the context of greater environmental adversity, nonshared environmental factors became more important in the etiology of INT symptoms. Conclusion Our results are consistent with the interpretation that environmental stressors have a causative effect on the emergence of INT disorders. The consistency of our results suggests a general mechanism of environmental influence on INT disorders regardless of the specific form of environmental risk. PMID:19594836

Gene-environment interplay in internalizing disorders: consistent findings across six environmental risk factors.

PubMed

Hicks, Brian M; DiRago, Ana C; Iacono, William G; McGue, Matt

2009-10-01

Behavior genetic methods can help to elucidate gene-environment (G-E) interplay in the development of internalizing (INT) disorders (i.e., major depression and anxiety disorders). To date, however, no study has conducted a comprehensive analysis examining multiple environmental risk factors with the purpose of delineating general mechanisms of G-E influence in the development of INT disorders. The sample consisted of 1315 male and female twin pairs participating in the age 17 assessment of the Minnesota Twin Family Study. Quantitative G-E interplay models were used to examine how genetic and environmental risk for INT disorders changes as a function of environmental context. Multiple measures and informants were employed to construct composite measures of INT disorders and six environmental risk factors including: stressful life events, mother-child and father-child relationship problems, antisocial and prosocial peer affiliation, and academic achievement and engagement. Significant moderation effects were detected between each environmental risk factor and INT such that in the context of greater environmental adversity, nonshared environmental factors became more important in the etiology of INT symptoms. Our results are consistent with the interpretation that environmental stressors have a causative effect on the emergence of INT disorders. The consistency of our results suggests a general mechanism of environmental influence on INT disorders regardless of the specific form of environmental risk.

Activation of int-1 and int-2 loci in GRf mammary tumors.

PubMed

Gray, D A; Jackson, D P; Percy, D H; Morris, V L

1986-10-30

The Mtv-2 locus is known to be associated with a high mammary tumor incidence (97%) and early development of mammary tumors (3-13 months) in GR mice. However, it was not previously known whether the provirus which resides at the Mtv-2 locus is tumorigenic in and of itself or whether reintegration of proviruses generated from Mtv-2 is required for tumorigenesis. Foster-nursing GR mice on C57/BL mice eliminates the milk-borne source of GR virus, and allows the study of Mtv-2 derived proviruses alone. Using this approach, we have tested predictions which follow from the "positional" versus "reintegrational" models of tumorigenesis. Specifically, we have examined tumors from primary foster-nursed (GRf) mice to determine if MMTV proviruses derived from Mtv-2 were scattered randomly throughout the genome or were clustered in the vicinity of the int-1 and int-2 loci, which are thought to be associated with mammary tumorigenesis. It was found that the majority of spontaneous GRf mammary tumors that were tested have MMTV proviral integrations in either or both of the int-1 and int-2 loci and have transcription of either or both of the int loci. Tumors induced by Mtv-2, therefore, appear to have arisen via a mechanism similar to the activation of the int loci by exogenous (milk-borne) MMTV proviruses.

Sequence specific peptidomimetic molecules inhibitors of a protein-protein interaction at the helix 1 level of c-Myc.

PubMed

Nieddu, Erika; Melchiori, A; Pescarolo, M P; Bagnasco, L; Biasotti, B; Licheri, B; Malacarne, D; Tortolina, L; Castagnino, N; Pasa, S; Cimoli, G; Avignolo, C; Ponassi, R; Balbi, C; Patrone, E; D'arrigo, C; Barboro, P; Vasile, F; Orecchia, P; Carnemolla, B; Damonte, G; Millo, E; Palomba, D; Fassina, G; Mazzei, M; Parodi, S

2005-04-01

Our work is focused in the broad area of strategies and efforts to inhibit protein-protein interactions. The possible strategies in this field are definitely much more varied than in the case of ATP-pocket inhibitors. In our previous work (10), we reported that a retro-inverso (RI) form of Helix1 (H1) of c-Myc, linked to an RI-internalization sequence arising from the third alpha-helix of Antennapedia (Int) was endowed with an antiproliferative and proapoptotic activity toward the cancer cell lines MCF-7 and HCT-116. The activity apparently was dependent upon the presence of the Myc motif. In this work, by ala-scan mapping of the H1 portion of our molecules with D-aa, we found two amino acids necessary for antiproliferative activity: D-Lys in 4 and D-Arg in 5 (numbers refer to L-forms). In the natural hetero-dimer, these two side chains project to the outside of the four alpha-helix bundle. Moreover, we were able to obtain three peptides more active than the original lead. They strongly reduced cell proliferation and survival (RI-Int-VV-H1-E2A,S6A,F8A; RI-Int-VV-H1-S6A,F8A,R11A; RI-Int-VV-H1-S6A,F8A,Q13A): after 8 days at 10 muM total cell number was approximately 1% of the number of cells initially seeded. In these more potent molecules, the ablated side chains project to the inside in the corresponding natural four alpha-helix bundle. In the present work, we also investigated the behavior of our molecules at the biochemical level. Using both a circular dichroism (CD) and a fluorescence anisotropy approach, we noted that side chains projecting at the interior of the four alpha-helix bundle are needed for inducing the partial unfolding of Myc-H2, without an opening of the leucine zipper. Side chains projecting at the outside are not required for this biochemical effect. However, antiproliferative activity had the opposite requirements: side chains projecting at the outside of the bundle were essential, and, on the contrary, ablation of one side chain at a time projecting at the inside increased rather than decreased biological activity. We conclude that our active molecules probably interfere at the level of a protein-protein interaction between Myc-Max and a third protein of the transcription complex. Finally, CD and nuclear magnetic resonance (NMR) data, plus dynamic simulations, suggest a prevalent random coil conformation of the H1 portion of our molecules, at least in diluted solutions. The introduction of a kink (substitution with proline in positions 5 or 7) led to an important reduction of biological activity. We have also synthesized a longer peptido-mimetic molecule (RI-Int-H1-S6A,F8A-loop-H2) with the intent of obtaining a wider zone of interaction and a stronger interference at the level of the higher-order structure (enhanceosome). RI-Int-H1-S6A,F8A-loop-H2 was less active rather than more active in respect to RI-Int-VV-H1-S6A,F8A, apparently because it has a clear bent to form a beta-sheet (CD and NMR data).

Impact of Excessive Weight Gain on Cardiovascular Outcomes in Type 1 Diabetes: Results From the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study.

PubMed

Purnell, Jonathan Q; Braffett, Barbara H; Zinman, Bernard; Gubitosi-Klug, Rose A; Sivitz, William; Bantle, John P; Ziegler, Georgia; Cleary, Patricia A; Brunzell, John D

2017-12-01

Intensive treatment (INT) of type 1 diabetes reduces the incidence of cardiovascular disease (CVD) events compared with conventional treatment (CONV), but it also results in more weight gain. Our objective was to examine whether excessive weight gain from INT of type 1 diabetes is independently associated with subsequent CVD events. Quartiles (Q) of weight gain in 1,213 participants aged 18 years and older at enrollment in the Diabetes Control and Complications Trial (DCCT) were determined within randomized treatment groups (INT vs. CONV) using change in BMI from baseline to the closeout DCCT visits. Effects of this weight gain on CVD risk factors and outcomes during an additional 20 years of observational follow-up were then determined. The Q4 INT group experienced greater proportional weight gain (median change in BMI, 6.08 kg/m 2 ), increases in CVD risk factors, and need for medications for hypertension and lipids compared with the Q1-3 INT and comparable CONV groups. Over a mean of 26 years of follow-up, the numbers of major and total CVD events were not statistically different in Q4 compared with Q1-3 of either the INT or CONV group. By year 14, however, the incident CVD event curve became significantly higher in the Q4 INT group than in the Q1-3 INT groups ( P = 0.024) and was similar to that for the CONV group. For the first 13 years after DCCT, INT for type 1 diabetes reduced macrovascular events compared with CONV, even when excessive weight gain occurred. After this, total CVD events significantly increased in the Q4 INT group, becoming equivalent to those in the CONV group. Longer follow-up is needed to determine whether this trend continues and results in more major CVD events. © 2017 by the American Diabetes Association.

Initial Characterization of the Pf-Int Recombinase from the Malaria Parasite Plasmodium falciparum

PubMed Central

Ghorbal, Mehdi; Scheidig-Benatar, Christine; Bouizem, Salma; Thomas, Christophe; Paisley, Genevieve; Faltermeier, Claire; Liu, Melanie; Scherf, Artur; Lopez-Rubio, Jose-Juan; Gopaul, Deshmukh N.

2012-01-01

Background Genetic variation is an essential means of evolution and adaptation in many organisms in response to environmental change. Certain DNA alterations can be carried out by site-specific recombinases (SSRs) that fall into two families: the serine and the tyrosine recombinases. SSRs are seldom found in eukaryotes. A gene homologous to a tyrosine site-specific recombinase has been identified in the genome of Plasmodium falciparum. The sequence is highly conserved among five other members of Plasmodia. Methodology/Principal Findings The predicted open reading frame encodes for a ∼57 kDa protein containing a C-terminal domain including the putative tyrosine recombinase conserved active site residues R-H-R-(H/W)-Y. The N-terminus has the typical alpha-helical bundle and potentially a mixed alpha-beta domain resembling that of λ-Int. Pf-Int mRNA is expressed differentially during the P. falciparum erythrocytic life stages, peaking in the schizont stage. Recombinant Pf-Int and affinity chromatography of DNA from genomic or synthetic origin were used to identify potential DNA targets after sequencing or micro-array hybridization. Interestingly, the sequences captured also included highly variable subtelomeric genes such as var, rif, and stevor sequences. Electrophoretic mobility shift assays with DNA were carried out to verify Pf-Int/DNA binding. Finally, Pf-Int knock-out parasites were created in order to investigate the biological role of Pf-Int. Conclusions/Significance Our data identify for the first time a malaria parasite gene with structural and functional features of recombinases. Pf-Int may bind to and alter DNA, either in a sequence specific or in a non-specific fashion, and may contribute to programmed or random DNA rearrangements. Pf-Int is the first molecular player identified with a potential role in genome plasticity in this pathogen. Finally, Pf-Int knock-out parasite is viable showing no detectable impact on blood stage development, which is compatible with such function. PMID:23056326

76 FR 13449 - Proposed Collection; Comment Request for Revenue Procedure 2009-41 (Rev. Proc. 2002-59 Is...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-11

... Classification Elections. DATES: Written comments should be received on or before May 10, 2011 to be assured of... Classification Elections. OMB Number: 1545-1771. Revenue Procedure Number: Revenue Procedure 2009-41. (Rev. Proc... Internal Revenue Code for an eligible entity that requests relief for a late classification election filed...

Using SAS PROC MCMC for Item Response Theory Models

ERIC Educational Resources Information Center

Ames, Allison J.; Samonte, Kelli

2015-01-01

Interest in using Bayesian methods for estimating item response theory models has grown at a remarkable rate in recent years. This attentiveness to Bayesian estimation has also inspired a growth in available software such as WinBUGS, R packages, BMIRT, MPLUS, and SAS PROC MCMC. This article intends to provide an accessible overview of Bayesian…

26 CFR 601.201 - Rulings and determinations letters.

Code of Federal Regulations, 2010 CFR

2010-04-01

... entire group. See, for example, Rev. Proc. 78-15, 1978-2 C.B. 488, and Rev. Proc. 78-16, 1978-2 C.B. 489... rulings to business, trade, or industrial associations or to other similar groups relating to the application of the tax laws to members of the group. However, rulings may be issued to such groups or...

26 CFR 601.201 - Rulings and determinations letters.

Code of Federal Regulations, 2011 CFR

2011-04-01

... entire group. See, for example, Rev. Proc. 78-15, 1978-2 C.B. 488, and Rev. Proc. 78-16, 1978-2 C.B. 489... rulings to business, trade, or industrial associations or to other similar groups relating to the application of the tax laws to members of the group. However, rulings may be issued to such groups or...

26 CFR 601.201 - Rulings and determinations letters.

Code of Federal Regulations, 2014 CFR

2014-04-01

... entire group. See, for example, Rev. Proc. 78-15, 1978-2 C.B. 488, and Rev. Proc. 78-16, 1978-2 C.B. 489... rulings to business, trade, or industrial associations or to other similar groups relating to the application of the tax laws to members of the group. However, rulings may be issued to such groups or...

26 CFR 601.201 - Rulings and determinations letters.

Code of Federal Regulations, 2013 CFR

2013-04-01

... entire group. See, for example, Rev. Proc. 78-15, 1978-2 C.B. 488, and Rev. Proc. 78-16, 1978-2 C.B. 489... rulings to business, trade, or industrial associations or to other similar groups relating to the application of the tax laws to members of the group. However, rulings may be issued to such groups or...

26 CFR 601.201 - Rulings and determinations letters.

Code of Federal Regulations, 2012 CFR

2012-04-01

... entire group. See, for example, Rev. Proc. 78-15, 1978-2 C.B. 488, and Rev. Proc. 78-16, 1978-2 C.B. 489... rulings to business, trade, or industrial associations or to other similar groups relating to the application of the tax laws to members of the group. However, rulings may be issued to such groups or...

Using SAS PROC MCMC for Item Response Theory Models

PubMed Central

Samonte, Kelli

2014-01-01

Interest in using Bayesian methods for estimating item response theory models has grown at a remarkable rate in recent years. This attentiveness to Bayesian estimation has also inspired a growth in available software such as WinBUGS, R packages, BMIRT, MPLUS, and SAS PROC MCMC. This article intends to provide an accessible overview of Bayesian methods in the context of item response theory to serve as a useful guide for practitioners in estimating and interpreting item response theory (IRT) models. Included is a description of the estimation procedure used by SAS PROC MCMC. Syntax is provided for estimation of both dichotomous and polytomous IRT models, as well as a discussion on how to extend the syntax to accommodate more complex IRT models. PMID:29795834

Tropical Cyclone Wind Threat for the Bay of Bengal.

DTIC Science & Technology

1979-10-01

7 vn PROcIASILIT:T.S OF Ev=’j’S WI4t4 :40S ’.z"mS 24RS 1WS 4444S ’OtjqS or 0ADO’JESS + . STTK WTI ; LEAT N.K T r.l~ *331 .1% .01 .01 .440 00 AT LE ...the - LEAST SQUARES ViAND LINE a.variability in initial position error or more specifically LIN reconnaissance support. The first component of the

Image-Based Techniques for Digitizing Environments and Artifacts

DTIC Science & Technology

2003-01-01

renderings in Fig. 7, and Maya Martinez arranged for the use of the cultural ar- tifacts used in this work. This work has been funded by Interval...Electronic Imaging and Computer Graphics in Mu- seum and Archaeology , pages 199–209, 1996. [3] R. Baribeau, M. Rioux, and G. Godin. Color reflectance...artifacts. In Proc. 2nd Inter- national Symposium on Virtual Reality, Archaeology , and Cultural Heritage (VAST 2001), pages 333–342, December 2001. [12

Crystal Resonators with Increased Immunity to Acceleration Fields

DTIC Science & Technology

1980-07-01

D. H. Donnay, McGill University; June :977, pp. 3-7. and M . J. Buerger and C. Frondel, Harvard University. 1241 M . Ono, K. Furusawa , S. Ishigami, T...crystal boundary to the mounting ’copnens supports. The stress distribution within the crystal depends t vi ron m ents of manpack and aircraft...Sase, and M . Sato, "Quartz crystal accelerometer insensitive to temperature variation," in Proc. 31stAFCS, June 1977, pp. 62-70. REFERENCES’ [251 D

A Rapid Computational Model for Estimating the Performance of Compliant Airfoils in Cascades

DTIC Science & Technology

1992-07-01

A.R., "Fluid Dynanics of Axial Compressors ", Proc. Instn. Mech. Engrs., No. 153, p. 445, 1945 7 APPENDIX A CASCADE AERODYNAMICS Initially we wish to...GROUP Turbomachinery Aeroelasticity 19 ABSTRACT (Continue on reverse if necessary and identify by block number) We consider the problem of designing ...Avila SUMMARY By designing the blades in a turbomachine to have a specific schedule of structural stiffness (typically more compliant than normal) it is

A Finite Difference Approximation for a Coupled System of Nonlinear Size-Structured Populations

DTIC Science & Technology

2000-01-01

are available. For a classical Lotka - Volterra competition model which is represented by a system of N di erential equations, conditions on the growth...Methods Appl. Sci., 9 (1999), 1379-1391. [5] S. Ahmed, Extinction of Species in Nonautonomous Lotka - Volterra Systems, Proc. Amer. Math. Soc., 127 (1999...Walter DeGruyter, Berlin, 1995. [7] S. Ahmed and F. Montes de Oca, Extinction in Nonautonomous T -periodic Lotka - Volterra System, Appl. Math. Comput

Specifying and Verifying Concurrent Programs.

DTIC Science & Technology

1985-02-01

for Verification and Specification of Concurrent Systems, held in La - Colle - Sur - Loup , France in October, 1984. Work Supported in part by the National...Proc. ACM Symposium on Princi- 0 ples of Programming Languages, Las Vegas, (January 1980), 251-261. [7] J. V. Guttag and J. J. Horning. An Introduction...names in ’V(S). However, the two formulas behave differently under a renaming mapping p. In particu- lar. p(Vv :A( LA )) equals Vv :p(A(v)), so the

Who, When, Where: Obfuscation Preferences in Location-Sharing Applications

DTIC Science & Technology

2011-06-01

location sharing preferences. There has been prior work on using obfuscation as a privacy preserving technique in the context of location based services [1,6,7,4...2004). Privacy in location - based services , concern vs. coolness. MobileHCI 2004 workshop: Location System Privacy and Control. 3. Benisch, M... based services , and the value of location. In Proc. of Ubicomp 2010. 5. Consolvo, S., Smith, I. E., Matthews, T., LaMarca, A., Tabert, J., Powledge, P

Robust Stability and Control of Multi-Body Ground Vehicles with Uncertain Dynamics and Failures

DTIC Science & Technology

2010-01-01

and N. Zhang, 2008. “Robust stability control of vehicle rollover subject to actuator time delay”. Proc. IMechE Part I: J. of systems and control ...Dynamic Systems and Control Conference, Boston, MA, Sept 2010 R.K. Yedavalli,”Robust Stability of Linear Interval Parameter Matrix Family Problem...for control coupled output regulation for a class of systems is presented. In section 2.1.7, the control design algorithm developed in section

The Design and Performance Characteristics of a Cellular Logic 3-D Image Classification Processor.

DTIC Science & Technology

1981-04-01

34 AGARD Proc. No. 94 on Artificiel Intelligence , 217: 1-13 (1971) 7. Golay, Marcel J. E. "Hexagonal Parallel Pattern Transformations." IEEE Trans. on...nonrandom nature of the data and features must be understood in order to intelligently select a reasonable three-dimensional noise filter. This completes...tactical targets which are located hundreds of meters away and are controlled and disguised by equally intelligent human beings, the difficulty of the

Chemoprevention of Breast Cancer by Mimicking the Protective Effect of Early First Birth

DTIC Science & Technology

2010-06-01

Endocrinol 2002;16:2034–51. 7. Thordarson G, Jin E, Guzman RC, Swanson SM, Nandi S, Talamantes F. Refractoriness to mammary tumori- genesis in parous rats...nitrosourea-induced mammary carcinomas in female Lewis rats. Carcinogenesis 1999;20:623–8. 11. Rajkumar L, Guzman RC, Yang J, Thordarson G...Guzman RC, Yang J, Rajkumar L, Thordarson G, Chen X, Nandi S. Hormonal prevention of breast cancer: mimicking the protective effect of pregnancy. Proc

Protein structure refinement using a quantum mechanics-based chemical shielding predictor† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc04344e Click here for additional data file.

PubMed Central

2017-01-01

The accurate prediction of protein chemical shifts using a quantum mechanics (QM)-based method has been the subject of intense research for more than 20 years but so far empirical methods for chemical shift prediction have proven more accurate. In this paper we show that a QM-based predictor of a protein backbone and CB chemical shifts (ProCS15, PeerJ, 2016, 3, e1344) is of comparable accuracy to empirical chemical shift predictors after chemical shift-based structural refinement that removes small structural errors. We present a method by which quantum chemistry based predictions of isotropic chemical shielding values (ProCS15) can be used to refine protein structures using Markov Chain Monte Carlo (MCMC) simulations, relating the chemical shielding values to the experimental chemical shifts probabilistically. Two kinds of MCMC structural refinement simulations were performed using force field geometry optimized X-ray structures as starting points: simulated annealing of the starting structure and constant temperature MCMC simulation followed by simulated annealing of a representative ensemble structure. Annealing of the CHARMM structure changes the CA-RMSD by an average of 0.4 Å but lowers the chemical shift RMSD by 1.0 and 0.7 ppm for CA and N. Conformational averaging has a relatively small effect (0.1–0.2 ppm) on the overall agreement with carbon chemical shifts but lowers the error for nitrogen chemical shifts by 0.4 ppm. If an amino acid specific offset is included the ProCS15 predicted chemical shifts have RMSD values relative to experiments that are comparable to popular empirical chemical shift predictors. The annealed representative ensemble structures differ in CA-RMSD relative to the initial structures by an average of 2.0 Å, with >2.0 Å difference for six proteins. In four of the cases, the largest structural differences arise in structurally flexible regions of the protein as determined by NMR, and in the remaining two cases, the large structural change may be due to force field deficiencies. The overall accuracy of the empirical methods are slightly improved by annealing the CHARMM structure with ProCS15, which may suggest that the minor structural changes introduced by ProCS15-based annealing improves the accuracy of the protein structures. Having established that QM-based chemical shift prediction can deliver the same accuracy as empirical shift predictors we hope this can help increase the accuracy of related approaches such as QM/MM or linear scaling approaches or interpreting protein structural dynamics from QM-derived chemical shift. PMID:28451325

Watershed Scale Stable Isotope Distribution and Implications on Soil Organic Carbon Loss Monitoring under Hydrologic Uncertainty

NASA Astrophysics Data System (ADS)

Ahmed, I.; Karim, A.; Boutton, T. W.; Strom, K.; Fox, J.

2013-12-01

The thematic focus of this 3-year period multidisciplinary USDA-CBG collaborative applied research is integrated monitoring of soil organic carbon (SOC) loss from multi-use lands using state-of-the-art stable isotope science under uncertain hydrologic influences. In this study, SOC loss and water runoff are being monitored on a 150 square kilometer watershed in Houston, Texas, using natural rainfall events, and total organic carbon/nitrogen concentration (TOC/TN) and stable isotope ratio (δ13C, δ15N) measurements with different land-use types. The work presents the interdisciplinary research results to uncover statistically valid and scientifically sound ways to monitor SOC loss by (i) application of Bayesian Markov Chain Monte Carlo statistical models to assess the relationship between rainfall-runoff and SOC release during soil erosion in space and time, (ii) capturing the episodic nature of rainfall events and its role in the spatial distribution of SOC loss from water erosion, (iii) stable isotope composition guided fingerprinting (source and quantity) of SOC by considering various types of erosion processes common in a heterogeneous watershed, to be able to tell what percentage of SOC is lost from various land-use types (Fox and Papanicolaou, 2008), (iv) creating an integrated watershed scale statistical soil loss monitoring model driven by spatial and temporal correlation of flow and stable isotope composition (Ahmed et. al., 2013a,b), and (v) creation of an integrated decision support system (DSS) for sustainable management of SOC under hydrologic uncertainty to assist the end users. References: Ahmed, I., Karim, A., Boutton, T.W., and Strom, K.B. (2013a). 'Monitoring Soil Organic Carbon Loss from Erosion Using Stable Isotopes.' Proc., Soil Carbon Sequestration, International Conference, May 26-29, Reykjavik, Iceland. Ahmed, I, Bouttom, T.W., Strom, K. B., Karim, A., and Irvin-Smith, N. (2013b). 'Soil carbon distribution and loss monitoring in the urbanized Buffalo Bayou watershed, Houston, Texas.' Proc., 4th Annual All Investigators Meeting of the North American Carbon Program, February 4-7, Albuquerque, NM. Fox, J.F. and Papanicolaou, A.N. (2008). An un-mixing model to study watershed erosion processes. Advances in Water Resources, 31, 96-108. ______________________________ * Corresponding author';s e-mail: ifahmed@pvamu.edu

Effects of Calcium, Vitamin D, and Hormone Therapy on Cardiovascular Disease Risk Factors in the Women's Health Initiative: A Randomized Controlled Trial

PubMed Central

Schnatz, Peter F.; Jiang, Xuezhi; Aragaki, Aaron K.; Nudy, Matthew; O'Sullivan, David M.; Williams, Mark; LeBlanc, Erin S.; Martin, Lisa W.; Manson, JoAnn E.; Shikany, James M.; Johnson, Karen C.; Stefanick, Marcia L.; Payne, Martha E.; Cauley, Jane A.; Howard, Barbara V.; Robbins, John

2016-01-01

Objective To analyze the treatment effect of calcium + Vitamin D supplementation, hormone therapy, both, and neither on cardiovascular disease risk factors. Methods We conducted a prospective, randomized, double-blind, placebo controlled trial among Women's Health Initiative participants. The predefined primary outcome was low-density lipoprotein cholesterol (LDL-C). Results Between September 1993 to October 1998, a total of 68,132 women aged 50-79 were recruited and randomized to the WHI-Dietary Modification (WHI-DM) (n=48,835) and WHI-Hormone Therapy (WHI-HT) trials (n=27,347). Subsequently, 36,282 women from WHI-HT (16,089) and WHI-DM (n=25,210) trials were randomized in the WHI-calcium + Vitamin D (WHI-CaD) trial to 1,000 mg of elemental calcium carbonate plus 400 IU of vitamin D3 daily or placebo. Our study group included 1,521 women who participated in both the HT and CaD trials and were in the 6% subsample of trial participants with blood sample collections at baseline and years 1, 3, and 6. The average treatment effect with 95% confidence interval, for LDL-C, compared to placebo, was −1.6 ,(95th CI–5.5, 2.2) mg/dL for calcium + Vitamin D-alone, −9.0 (95th CI, −13.0, −5.1) mg/dL for hormone therapy alone, and −13.8 (95th CI,−17.8, −9.8) mg/dL for the combination. There was no evidence of a synergistic effect of calcium + Vitamin D + hormone therapy on LDL-C (p-value for interaction (p-int) = 0.26) except in those with low total intakes of vitamin D, for whom there was a significant synergistic effect on LDL (p-int = 0.03). Conclusion Reductions in LDL-C were greater among women randomized to both calcium + Vitamin D and hormone therapy than for those randomized to either intervention alone or to placebo. The treatment effect observed in the calcium + Vitamin D + hormone therapy combination group may be additive rather than synergistic. For clinicians and patients deciding to begin calcium + Vitamin D supplementation, current use of hormone therapy should not influence that decision. PMID:27926633

Differences in the response of soil dehydrogenase activity to Cd contamination are determined by the different substrates used for its determination.

PubMed

Tan, Xiangping; Liu, Yanju; Yan, Kaihong; Wang, Ziquan; Lu, Guannan; He, Yike; He, Wenxiang

2017-02-01

Dehydrogenase activity (DHA) is an important indicator of heavy metal toxicity in contaminated soils. Different instances of DHA were determined using various substrates and which could affect the description of heavy metal toxicity. Currently, too few investigations have been done on selecting appropriate substrates. This study employed indoor simulation to determine soil DHA and its response to external cadmium (Cd) using two substrates (TTC and INT). Hormesis for DHA obtained using the TTC method (DHA-TTC) in low Cd concentration was observed which was quickly inhibited in high Cd concentration. While DHA obtained using the INT method (DHA-INT) decreased slowly when Cd concentration increased. The DHA-TTC and DHA-INT in soils at Cd concentration of 500 mg kg -1 decreased 86% and 53%, respectively, compared to the control. The dose-response relationship of Cd to DHA can be well simulated using the logistic model (p < 0.01), which indicated DHA could be used to indicate soil Cd toxicity. Multiple stepwise regression analysis revealed that total organic matter (TOC) is the major factor influencing the toxicity of Cd to DHA-TTC, while TOC, pH and cation exchange capacity (CEC) are major factors influencing the toxicity of Cd to DHA-INT. The different responses of soil DHA-TTC and DHA-INT to Cd are due to the differences in electron transport chain characteristics between TTC and INT, as well as the influence of soil properties. Although both DHA-TTC and DHA-INT can monitor soil Cd contamination, DHA-INT is recommended as a superior bio-indicator to indicate and assess contamination of Cd in soil. Copyright © 2016 Elsevier Ltd. All rights reserved.

Steady-State Operation in Tore Supra

NASA Astrophysics Data System (ADS)

Hoang, G. T.; Tore Supra, Equipe

1999-11-01

The Tore Supra superconducting tokamak is devoted to steady-state operation. The CIEL (French acronym for internal component and limiter) project( LIPA, M., et al., Proc. of the 17th IEEE/NPSS Symp. on Fus. Engineering, San Diego, USA, 1997.) consists of a complete upgrade of the inner chamber of Tore Supra, planned to be installed during the year 2000. This project will allow physics scenarios with up to 24 MW of radio frequency heating and current drive (typically 8 - 10 MW of ICRF, 10 - 12 MW of LHCD and 2 MW of ECRF) in stationary plasmas up to 1000 s, with active particle control. This paper presents an overview of the experiments planned to explore the properties, such as the confinement and MHD stability, of various heating and current drive scenarios for long duration discharges. The expected performance for the CIEL phase is also reported.