Sample records for process control issues

  1. Design issues of a reinforcement-based self-learning fuzzy controller for petrochemical process control

    NASA Technical Reports Server (NTRS)

    Yen, John; Wang, Haojin; Daugherity, Walter C.

    1992-01-01

    Fuzzy logic controllers have some often-cited advantages over conventional techniques such as PID control, including easier implementation, accommodation to natural language, and the ability to cover a wider range of operating conditions. One major obstacle that hinders the broader application of fuzzy logic controllers is the lack of a systematic way to develop and modify their rules; as a result the creation and modification of fuzzy rules often depends on trial and error or pure experimentation. One of the proposed approaches to address this issue is a self-learning fuzzy logic controller (SFLC) that uses reinforcement learning techniques to learn the desirability of states and to adjust the consequent part of its fuzzy control rules accordingly. Due to the different dynamics of the controlled processes, the performance of a self-learning fuzzy controller is highly contingent on its design. The design issue has not received sufficient attention. The issues related to the design of a SFLC for application to a petrochemical process are discussed, and its performance is compared with that of a PID and a self-tuning fuzzy logic controller.

  2. Design issues for a reinforcement-based self-learning fuzzy controller

    NASA Technical Reports Server (NTRS)

    Yen, John; Wang, Haojin; Dauherity, Walter

    1993-01-01

    Fuzzy logic controllers have some often cited advantages over conventional techniques such as PID control: easy implementation, its accommodation to natural language, the ability to cover wider range of operating conditions and others. One major obstacle that hinders its broader application is the lack of a systematic way to develop and modify its rules and as result the creation and modification of fuzzy rules often depends on try-error or pure experimentation. One of the proposed approaches to address this issue is self-learning fuzzy logic controllers (SFLC) that use reinforcement learning techniques to learn the desirability of states and to adjust the consequent part of fuzzy control rules accordingly. Due to the different dynamics of the controlled processes, the performance of self-learning fuzzy controller is highly contingent on the design. The design issue has not received sufficient attention. The issues related to the design of a SFLC for the application to chemical process are discussed and its performance is compared with that of PID and self-tuning fuzzy logic controller.

  3. Advanced data management design for autonomous telerobotic systems in space using spaceborne symbolic processors

    NASA Technical Reports Server (NTRS)

    Goforth, Andre

    1987-01-01

    The use of computers in autonomous telerobots is reaching the point where advanced distributed processing concepts and techniques are needed to support the functioning of Space Station era telerobotic systems. Three major issues that have impact on the design of data management functions in a telerobot are covered. It also presents a design concept that incorporates an intelligent systems manager (ISM) running on a spaceborne symbolic processor (SSP), to address these issues. The first issue is the support of a system-wide control architecture or control philosophy. Salient features of two candidates are presented that impose constraints on data management design. The second issue is the role of data management in terms of system integration. This referes to providing shared or coordinated data processing and storage resources to a variety of telerobotic components such as vision, mechanical sensing, real-time coordinated multiple limb and end effector control, and planning and reasoning. The third issue is hardware that supports symbolic processing in conjunction with standard data I/O and numeric processing. A SSP that currently is seen to be technologically feasible and is being developed is described and used as a baseline in the design concept.

  4. How does a specific learning and memory system in the mammalian brain gain control of behavior?

    PubMed

    McDonald, Robert J; Hong, Nancy S

    2013-11-01

    This review addresses a fundamental, yet poorly understood set of issues in systems neuroscience. The issues revolve around conceptualizations of the organization of learning and memory in the mammalian brain. One intriguing, and somewhat popular, conceptualization is the idea that there are multiple learning and memory systems in the mammalian brain and they interact in different ways to influence and/or control behavior. This approach has generated interesting empirical and theoretical work supporting this view. One issue that needs to be addressed is how these systems influence or gain control of voluntary behavior. To address this issue, we clearly specify what we mean by a learning and memory system. We then review two types of processes that might influence which memory system gains control of behavior. One set of processes are external factors that can affect which system controls behavior in a given situation including task parameters like the kind of information available to the subject, types of training experience, and amount of training. The second set of processes are brain mechanisms that might influence what memory system controls behavior in a given situation including executive functions mediated by the prefrontal cortex; switching mechanisms mediated by ascending neurotransmitter systems, the unique role of the hippocampus during learning. The issue of trait differences in control of different learning and memory systems will also be considered in which trait differences in learning and memory function are thought to potentially emerge from differences in level of prefrontal influence, differences in plasticity processes, differences in ascending neurotransmitter control, differential access to effector systems like motivational and motor systems. Finally, we present scenarios in which different mechanisms might interact. This review was conceived to become a jumping off point for new work directed at understanding these issues. The outcome of this work, in combination with other approaches, might improve understanding of the mechanisms of volition in human and non-human animals. Copyright © 2013 Wiley Periodicals, Inc.

  5. The application of intelligent process control to space based systems

    NASA Technical Reports Server (NTRS)

    Wakefield, G. Steve

    1990-01-01

    The application of Artificial Intelligence to electronic and process control can help attain the autonomy and safety requirements of manned space systems. An overview of documented applications within various industries is presented. The development process is discussed along with associated issues for implementing an intelligence process control system.

  6. CLASS A PROCESS USAGE AND RELATED ISSUES: A PATHOGEN EQUIVALENCY COMMITTEE PERSPECTIVE

    EPA Science Inventory

    This paper looks at the factors influencing the land application of biosolids and usage of Class A processes. It reviews the commonly employed Class A processes for controlling pathogens; notes how extensively they are used; discusses issues and concerns with some of them; and it...

  7. Automation and control of off-planet oxygen production processes

    NASA Technical Reports Server (NTRS)

    Marner, W. J.; Suitor, J. W.; Schooley, L. S.; Cellier, F. E.

    1990-01-01

    This paper addresses several aspects of the automation and control of off-planet production processes. First, a general approach to process automation and control is discussed from the viewpoint of translating human process control procedures into automated procedures. Second, the control issues for the automation and control of off-planet oxygen processes are discussed. Sensors, instruments, and components are defined and discussed in the context of off-planet applications, and the need for 'smart' components is clearly established.

  8. Computer-Mediated Group Processes in Distributed Command and Control Systems

    DTIC Science & Technology

    1988-06-01

    Linville, "Michael J. Liebhaber, and Richard W. Obermayer Vreuls Corporation Jon J. Fallesen Army Research Institute DTIC SELECTEr • AUG I 1. 1988 ARI...control staffs who will operate in a computer- mediated environment. The Army Research Institute has initiated research to examine selected issues...computar-mediated group processes is needed. Procedure: The identification and selection of key research issues followed a three- step procedure. Previous

  9. Dynamic control and information processing in chemical reaction systems by tuning self-organization behavior

    NASA Astrophysics Data System (ADS)

    Lebiedz, Dirk; Brandt-Pollmann, Ulrich

    2004-09-01

    Specific external control of chemical reaction systems and both dynamic control and signal processing as central functions in biochemical reaction systems are important issues of modern nonlinear science. For example nonlinear input-output behavior and its regulation are crucial for the maintainance of the life process that requires extensive communication between cells and their environment. An important question is how the dynamical behavior of biochemical systems is controlled and how they process information transmitted by incoming signals. But also from a general point of view external forcing of complex chemical reaction processes is important in many application areas ranging from chemical engineering to biomedicine. In order to study such control issues numerically, here, we choose a well characterized chemical system, the CO oxidation on Pt(110), which is interesting per se as an externally forced chemical oscillator model. We show numerically that tuning of temporal self-organization by input signals in this simple nonlinear chemical reaction exhibiting oscillatory behavior can in principle be exploited for both specific external control of dynamical system behavior and processing of complex information.

  10. Quality by design for herbal drugs: a feedforward control strategy and an approach to define the acceptable ranges of critical quality attributes.

    PubMed

    Yan, Binjun; Li, Yao; Guo, Zhengtai; Qu, Haibin

    2014-01-01

    The concept of quality by design (QbD) has been widely accepted and applied in the pharmaceutical manufacturing industry. There are still two key issues to be addressed in the implementation of QbD for herbal drugs. The first issue is the quality variation of herbal raw materials and the second issue is the difficulty in defining the acceptable ranges of critical quality attributes (CQAs). To propose a feedforward control strategy and a method for defining the acceptable ranges of CQAs for the two issues. In the case study of the ethanol precipitation process of Danshen (Radix Salvia miltiorrhiza) injection, regression models linking input material attributes and process parameters to CQAs were built first and an optimisation model for calculating the best process parameters according to the input materials was established. Then, the feasible material space was defined and the acceptable ranges of CQAs for the previous process were determined. In the case study, satisfactory regression models were built with cross-validated regression coefficients (Q(2) ) all above 91 %. The feedforward control strategy was applied successfully to compensate the quality variation of the input materials, which was able to control the CQAs in the 90-110 % ranges of the desired values. In addition, the feasible material space for the ethanol precipitation process was built successfully, which showed the acceptable ranges of the CQAs for the concentration process. The proposed methodology can help to promote the implementation of QbD for herbal drugs. Copyright © 2013 John Wiley & Sons, Ltd.

  11. Special Issue on Optochemical and Optogenetic Control of Cellular Processes.

    PubMed

    Deiters, Alexander

    2018-06-06

    Diverse optochemical and optobiological approaches are being developed and applied to the light-regulation of cellular processes with exquisite spatial and temporal resolution in cells and multicellular model organisms. In this special issue, experts report some of the latest progress in the expanding field of the optical control of biological systems and present an overview of the state of the art of select approaches. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. Knowledge-based processing for aircraft flight control

    NASA Technical Reports Server (NTRS)

    Painter, John H.; Glass, Emily; Economides, Gregory; Russell, Paul

    1994-01-01

    This Contractor Report documents research in Intelligent Control using knowledge-based processing in a manner dual to methods found in the classic stochastic decision, estimation, and control discipline. Such knowledge-based control has also been called Declarative, and Hybid. Software architectures were sought, employing the parallelism inherent in modern object-oriented modeling and programming. The viewpoint adopted was that Intelligent Control employs a class of domain-specific software architectures having features common over a broad variety of implementations, such as management of aircraft flight, power distribution, etc. As much attention was paid to software engineering issues as to artificial intelligence and control issues. This research considered that particular processing methods from the stochastic and knowledge-based worlds are duals, that is, similar in a broad context. They provide architectural design concepts which serve as bridges between the disparate disciplines of decision, estimation, control, and artificial intelligence. This research was applied to the control of a subsonic transport aircraft in the airport terminal area.

  13. U.S.-Russian cooperation in nuclear disarmament and nonproliferation

    NASA Astrophysics Data System (ADS)

    Podvig, Pavel

    2010-02-01

    The United States and Russia, the two largest nuclear powers, have a special obligation to provide leadership in nuclear disarmament and in strengthening the nuclear non-proliferation regime. In the past year the two countries made an effort to restart the arms control process by concluding a new treaty that would bring their legal disarmament obligations in line with the realities of their post-cold war relationships. The process of negotiating deeper nuclear reductions in the new environment turned out to be rather difficult, since the approaches that the countries used in the past are not well suited to dealing with issues like conversion of strategic nuclear delivery systems to conventional missions, tactical nuclear weapons, or dismantlement of nuclear warheads. This presentation considers the recent progress in U.S.-Russian arms control process and outlines the key issues at the negotiations. It also considers prospects for further progress in bilateral nuclear disarmament and issues that will be encountered at later stages of the process. The author argues that success of the arms reductions will depend on whether the United States and Russia will be able to build an institutional framework for cooperation on a range of issues - from traditional arms control to securing nuclear materials and from missile defense to strengthening the international nuclear safeguards. )

  14. Communication Security for Control Systems in Smart Grid

    NASA Astrophysics Data System (ADS)

    Robles, Rosslin John; Kim, Tai-Hoon

    As an example of Control System, Supervisory Control and Data Acquisition systems can be relatively simple, such as one that monitors environmental conditions of a small office building, or incredibly complex, such as a system that monitors all the activity in a nuclear power plant or the activity of a municipal water system. SCADA systems are basically Process Control Systems, designed to automate systems such as traffic control, power grid management, waste processing etc. Connecting SCADA to the Internet can provide a lot of advantages in terms of control, data viewing and generation. SCADA infrastructures like electricity can also be a part of a Smart Grid. Connecting SCADA to a public network can bring a lot of security issues. To answer the security issues, a SCADA communication security solution is proposed.

  15. Contexts of Congressional Decision Behavior

    DTIC Science & Technology

    1979-01-01

    type, issue dimension measured, and data source. This research design al:o employed controls for member backgrounds and constituency characteristics...34 Contextual Theory . . 15 1. The Integration of Contending Models of the Legislative Process ............ 15 2. The Transcendence of "Static" Research Designs ...Issue.Characteristics . . ........ 1713 3. Communications Controlled by Background and Constituency Factors . . . . . . . . . . . . . . .18:3 0. Summary and

  16. Design and analysis issues of integrated control systems for high-speed civil transports

    NASA Technical Reports Server (NTRS)

    Mccarty, Craig A.; Feather, John B.; Dykman, John R.; Page, Mark A.; Hodgkinson, John

    1992-01-01

    A study was conducted to identify, rank, and define development plans for the critical guidance and control design and analysis issues as related to economically viable and environmentally acceptable high-speed civil transport. The issues were identified in a multistep process. First, pertinent literature on supersonic cruise aircraft was reviewed, and experts were consulted to establish the fundamental characteristics and problems inherent to supersonic cruise aircraft. Next, the advanced technologies and strategies being pursued for the high-speed civil transport were considered to determine any additional unique control problems the transport may have. Finally, existing technologies and methods were examined to determine their capabilities for the design and analysis of high-speed civil transport control systems and to identify the shortcomings and issues. Three priority levels - mandatory, highly beneficial, and desirable - were established. Within each of these levels, the issues were further ranked. Technology development plans for each issue were defined. Each plan contains a task breakdown and schedule.

  17. CHANGING APPROACHES TO CONTROLLING PATHOGENS IN BIOSOLIDS AND THEIR VECTOR ATTRACTIVENESS

    EPA Science Inventory

    This paper reviews the commonly employed Class A and B processes for controlling pathogens; notes how extensively they are used; and discusses issues and concerns with some of them. Processes presently being researched are also noted together with EPA's methodology for determinin...

  18. Knowledge-Based Integrated Information Systems Engineering: Highlights and Bibliography. Volume 1.

    DTIC Science & Technology

    1987-12-01

    of database technology, 0 communication technology and expert systems technology. , Organizational issues cover the process of making controlled... process of linking strategic goals, technical issues , and organizational aspects can be depicted as shown in Figure 2.2. At the top level, strategic...an integrated information system design and implementation in a short period of time [4]. 2.2.2 Emphasis on Process It was mentioned in Section 1.3

  19. Design of distributed systems of hydrolithospere processes management. Selection of optimal number of extracting wells

    NASA Astrophysics Data System (ADS)

    Pershin, I. M.; Pervukhin, D. A.; Ilyushin, Y. V.; Afanaseva, O. V.

    2017-10-01

    The article considers the important issue of designing the distributed systems of hydrolithospere processes management. Control effects on the hydrolithospere processes are implemented by a set of extractive wells. The article shows how to determine the optimal number of extractive wells that provide a distributed control impact on the management object.

  20. Atmosphere Explorer control system software (version 1.0)

    NASA Technical Reports Server (NTRS)

    Villasenor, A.

    1972-01-01

    The basic design is described of the Atmosphere Explorer Control System (AECS) software used in the testing, integration, and flight contol of the AE spacecraft and experiments. The software performs several vital functions, such as issuing commands to the spacecraft and experiments, receiving and processing telemetry data, and allowing for extensive data processing by experiment analysis programs. The major processing sections are: executive control section, telemetry decommutation section, command generation section, and utility section.

  1. ARE THERE PATHOGENS IN YOUR SEWAGE SLUDGE? CHANGING APPROAHCES TO CONTROLLING PATHOGENS IN SEWAGE SLUDGE AND THEIR VECTOR ATTRACTIVENESS.

    EPA Science Inventory

    This presentation will review the commonly employed Class A & B processes for controlling pathogens; note how extensively they are used; and discuss issues and concerns. Processes presently being researched will also be noted together with EPA's methodology for determining equiva...

  2. Optimization of Process Parameters of Edge Robotic Deburring with Force Control

    NASA Astrophysics Data System (ADS)

    Burghardt, A.; Szybicki, D.; Kurc, K.; Muszyńska, M.

    2016-12-01

    The issues addressed in the paper present a part of the scientific research conducted within the framework of the automation of the aircraft engine part manufacturing processes. The results of the research presented in the article provided information in which tolerances while using a robotic control station with the option of force control we can make edge deburring.

  3. Issue Management and the Australian Gun Debate.

    ERIC Educational Resources Information Center

    Reynolds, Christopher

    1997-01-01

    Examines the rise and fall of media coverage of the issues of gun control and political conflict in Australia after an incident of mass murder in April 1996. Aims to reveal the issue management process that occurred and the hidden agendas that motivated the political and media activity. Demonstrates the media's role in the creation of issue…

  4. Biofouling of Water Treatment Membranes: A Review of the Underlying Causes, Monitoring Techniques and Control Measures

    PubMed Central

    Nguyen, Thang; Roddick, Felicity A.; Fan, Linhua

    2012-01-01

    Biofouling is a critical issue in membrane water and wastewater treatment as it greatly compromises the efficiency of the treatment processes. It is difficult to control, and significant economic resources have been dedicated to the development of effective biofouling monitoring and control strategies. This paper highlights the underlying causes of membrane biofouling and provides a review on recent developments of potential monitoring and control methods in water and wastewater treatment with the aim of identifying the remaining issues and challenges in this area. PMID:24958430

  5. Additive Manufacturing: Ensuring Quality for Spacecraft Applications

    NASA Technical Reports Server (NTRS)

    Swanson, Theodore; Stephenson, Timothy

    2014-01-01

    Reliable manufacturing requires that material properties and fabrication processes be well defined in order to insure that the manufactured parts meet specified requirements. While this issue is now relatively straightforward for traditional processes such as subtractive manufacturing and injection molding, this capability is still evolving for AM products. Hence, one of the principal challenges within AM is in qualifying and verifying source material properties and process control. This issue is particularly critical for applications in harsh environments and demanding applications, such as spacecraft.

  6. State Analysis: A Control Architecture View of Systems Engineering

    NASA Technical Reports Server (NTRS)

    Rasmussen, Robert D.

    2005-01-01

    A viewgraph presentation on the state analysis process is shown. The topics include: 1) Issues with growing complexity; 2) Limits of common practice; 3) Exploiting a control point of view; 4) A glimpse at the State Analysis process; 5) Synergy with model-based systems engineering; and 6) Bridging the systems to software gap.

  7. Chemical Stockpile Disposal Program. Monitoring Concept Plan

    DTIC Science & Technology

    1987-09-10

    Government Owned Contractor Operated GPL General Population Limit H Bis (2-chloroethyl) sulfide or Levinstein Mustard (75% purity) P HCI Hydrogen Chloride... government agencies, will provide technical expertise and equipment necessary to monitor affected areas and resources. 2-25 SECTIO 3 PROCESS CONTROL AND...conditions and to issue correct emergency response notifications, if required. The process sensors work in conjunction with the process control system and

  8. Naval Surface Warfare Center Crane Contracts Awarded Without Competition Were Adequately Justified

    DTIC Science & Technology

    2012-04-24

    Processed Data 13 Use of Technical Assistance 14 Prior Coverage 14 B. Federal Acquisition Regulation Criteria...are operating as intended and to evaluate the effectiveness of the controls. NSWC Crane’s internal controls over their processes for issuing the...consider the problem to be systemic and are not making a recommendation. Processes at NSWC Crane Facilitate Market Research Efforts NSWC Crane

  9. Manipulating Color and Other Visual Information Influences Picture Naming at Different Levels of Processing: Evidence from Alzheimer Subjects and Normal Controls

    ERIC Educational Resources Information Center

    Zannino, Gian Daniele; Perri, Roberta; Salamone, Giovanna; Di Lorenzo, Concetta; Caltagirone, Carlo; Carlesimo, Giovanni A.

    2010-01-01

    There is now a large body of evidence suggesting that color and photographic detail exert an effect on recognition of visually presented familiar objects. However, an unresolved issue is whether these factors act at the visual, the semantic or lexical level of the recognition process. In the present study, we investigated this issue by having…

  10. Validation results of specifications for motion control interoperability

    NASA Astrophysics Data System (ADS)

    Szabo, Sandor; Proctor, Frederick M.

    1997-01-01

    The National Institute of Standards and Technology (NIST) is participating in the Department of Energy Technologies Enabling Agile Manufacturing (TEAM) program to establish interface standards for machine tool, robot, and coordinate measuring machine controllers. At NIST, the focus is to validate potential application programming interfaces (APIs) that make it possible to exchange machine controller components with a minimal impact on the rest of the system. This validation is taking place in the enhanced machine controller (EMC) consortium and is in cooperation with users and vendors of motion control equipment. An area of interest is motion control, including closed-loop control of individual axes and coordinated path planning. Initial tests of the motion control APIs are complete. The APIs were implemented on two commercial motion control boards that run on two different machine tools. The results for a baseline set of APIs look promising, but several issues were raised. These include resolving differing approaches in how motions are programmed and defining a standard measurement of performance for motion control. This paper starts with a summary of the process used in developing a set of specifications for motion control interoperability. Next, the EMC architecture and its classification of motion control APIs into two classes, Servo Control and Trajectory Planning, are reviewed. Selected APIs are presented to explain the basic functionality and some of the major issues involved in porting the APIs to other motion controllers. The paper concludes with a summary of the main issues and ways to continue the standards process.

  11. 21 CFR 1311.302 - Additional application provider requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... part, the application provider must notify practitioners or pharmacies that use the application as soon... practitioners or pharmacies with updates to any issue that makes the application non-compliant with the... practitioner or pharmacy may use the application to issue or process electronic controlled substance...

  12. 78 FR 25436 - SFIREG Environmental Quality Issues Committee; Notice of Public Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-01

    ... human health, environmental exposure to pesticides, and insight into EPA's decision-making process. You.... SUMMARY: The Association of American Pesticide Control Officials (AAPCO)/State FIFRA Issues Research and... External Affairs Division (7506P), Office of Pesticide Programs, Environmental Protection Agency, 1200...

  13. Editorial

    NASA Astrophysics Data System (ADS)

    Al-Sheikhly, Mohamad; Varca, Gustavo H. C.

    2018-02-01

    We are very proud and delighted to introduce this special issue of Radiation Physics and Chemistry (RPC). It is indeed the fruit of an outstanding, collective effort by radiation chemists and physicists, as well as radiation processing and nuclear engineers, who presented their research at the 18th International Meeting of Radiation Processing (IMRP) 2016 in Vancouver, Canada. This valuable issue covers a wide range of reported new results in the field of radiation chemistry, physics, and processing. Eminent scientists carefully selected these invited papers, followed by a thorough reviewing process. This issue presents the selected sixteen invited papers. These papers cover fundamental radiation chemistry mechanisms and kinetics, radiation-induced polymerization and kinetics, radiation effects on synthetic and natural polymers, radiation processing control and quality assurances, radiation-induced preservation of food, radiation sterilization, radiation dosimetry, and radiation synthesis of various fabrics for remediation of nuclear isotopes such as cesium.

  14. Issues in NASA Program and Project Management:: A Collection of Papers on Aerospace Management Issues (Supplement 11)

    NASA Technical Reports Server (NTRS)

    Hoffman, Edward J. (Editor); Lawbaugh, William M. (Editor)

    1996-01-01

    Papers address the following topics: NASA's project management development process; Better decisions through structural analysis; NASA's commercial technology management system; Today's management techniques and tools; Program control in NASA - needs and opportunities; and Resources for NASA managers.

  15. Regulation of Cognitive Processes through Perceived Self-Efficacy.

    ERIC Educational Resources Information Center

    Bandura, Albert

    1989-01-01

    Addresses issues concerning the extension of self-efficacy theory to memory functioning. Issues include perceived memory capabilities, memory self-appraisal, personal control over memory functioning, preservation of a favorable sense of memory self-efficacy, and strategies for generalizing the impact of training in memory skills. (RJC)

  16. The political context of health service regulation.

    PubMed

    Krause, E A

    1975-01-01

    Can regulation work in health services, given the present political context? General issues in the regulatory process are discussed, followed by a consideration of the relevance of these issues to the health care field. Regulatory processes are reviewed for the United States in four areas: credentialling of people, surveillance of delivery systems, quality of materials and technology, and rate-setting or cost control. It is concluded that the process cannot work. Four alternatives are presented and briefly evaluated: tinkering, centralized regulation, national health service, and general nationalization of most major economic sectors.

  17. Contamination Mitigation Strategies for Long Duration Human Spaceflight Missions

    NASA Technical Reports Server (NTRS)

    Lewis, Ruthan; Lupisella, Mark; Bleacher, Jake; Farrell, William

    2017-01-01

    Contamination control issues are particularly challenging for long-term human spaceflight and are associated with the search for life, dynamic environmental conditions, human-robotic-environment interaction, sample collection and return, biological processes, waste management, long-term environmental disturbance, etc. These issues impact mission success, human health, planetary protection, and research and discovery. Mitigation and control techniques and strategies may include and integrate long-term environmental monitoring and reporting, contamination control and planetary protection protocols, habitation site design, habitat design, and surface exploration and traverse pathways and area access planning.

  18. On the fragility of fractional-order PID controllers for FOPDT processes.

    PubMed

    Padula, Fabrizio; Visioli, Antonio

    2016-01-01

    This paper analyzes the fragility issue of fractional-order proportional-integral-derivative controllers applied to integer first-order plus-dead-time processes. In particular, the effects of the variations of the controller parameters on the achieved control system robustness and performance are investigated. Results show that this kind of controllers is more fragile with respect to the standard proportional-integral-derivative controllers and therefore a significant attention should be paid by the user in their tuning. Copyright © 2015 ISA. Published by Elsevier Ltd. All rights reserved.

  19. An overview of selected information storage and retrieval issues in computerized document processing

    NASA Technical Reports Server (NTRS)

    Dominick, Wayne D. (Editor); Ihebuzor, Valentine U.

    1984-01-01

    The rapid development of computerized information storage and retrieval techniques has introduced the possibility of extending the word processing concept to document processing. A major advantage of computerized document processing is the relief of the tedious task of manual editing and composition usually encountered by traditional publishers through the immense speed and storage capacity of computers. Furthermore, computerized document processing provides an author with centralized control, the lack of which is a handicap of the traditional publishing operation. A survey of some computerized document processing techniques is presented with emphasis on related information storage and retrieval issues. String matching algorithms are considered central to document information storage and retrieval and are also discussed.

  20. Intelligent monitoring and control of semiconductor manufacturing equipment

    NASA Technical Reports Server (NTRS)

    Murdock, Janet L.; Hayes-Roth, Barbara

    1991-01-01

    The use of AI methods to monitor and control semiconductor fabrication in a state-of-the-art manufacturing environment called the Rapid Thermal Multiprocessor is described. Semiconductor fabrication involves many complex processing steps with limited opportunities to measure process and product properties. By applying additional process and product knowledge to that limited data, AI methods augment classical control methods by detecting abnormalities and trends, predicting failures, diagnosing, planning corrective action sequences, explaining diagnoses or predictions, and reacting to anomalous conditions that classical control systems typically would not correct. Research methodology and issues are discussed, and two diagnosis scenarios are examined.

  1. Building new hospitals: a UK infection control perspective.

    PubMed

    Stockley, J M; Constantine, C E; Orr, K E

    2006-03-01

    Infection control input is vital throughout the planning, design and building stages of a new hospital project, and must continue through the commissioning (and decommissioning) process, evaluation and putting the facility into full clinical service. Many hospitals continue to experience problems months or years after occupying the new premises; some of these could have been avoided by infection control involvement earlier in the project. The importance of infection control must be recognized by the chief executive of the hospital trust and project teams overseeing the development. Clinical user groups and contractors must also be made aware of infection control issues. It is vital that good working relationships are built up between the infection control team (ICT) and all these parties. ICTs need the authority to influence the process. This may require their specific recognition by the Private Finance Initiative National Unit, the Department of Health or other relevant authorities. ICTs need training in how to read design plans, how to write effective specifications, and in other areas with which they may be unfamiliar. The importance of documentation and record keeping is paramount. External or independent validation of processes should be available, particularly in commissioning processes. Building design in relation to infection control needs stricter national regulations, allowing ICTs to focus on more local usage issues. Further research is needed to provide evidence regarding the relationship between building design and the prevalence of infection.

  2. Medical devices; hematology and pathology devices; classification of cord blood processing system and storage container. Final rule.

    PubMed

    2007-02-01

    The Food and Drug Administration (FDA) is classifying a cord blood processing system and storage container into class II (special controls). The special control that will apply to this device is the guidance document entitled "Class II Special Controls Guidance Document: Cord Blood Processing System and Storage Container." FDA is classifying this device into class II (special controls) in order to provide a reasonable assurance of safety and effectiveness of this device. Elsewhere in this issue of the Federal Register, FDA is announcing the availability of the guidance document that will serve as the special control for this device.

  3. Integrated Business Process Adaptation towards Friction-Free Business-to-Business Collaboration

    ERIC Educational Resources Information Center

    Shan, Zhe

    2011-01-01

    One key issue in process-aware E-commerce collaboration is the orchestration of business processes of multiple business partners throughout a supply chain network in an automated and seamless way. Since each partner has its own internal processes with different control flow structures and message interfaces, the real challenge lies in verifying…

  4. Enhancing diabetes management while teaching quality improvement methods.

    PubMed

    Sievers, Beth A; Negley, Kristin D F; Carlson, Marny L; Nelson, Joyce L; Pearson, Kristina K

    2014-01-01

    Six medical units realized that they were having issues with accurate timing of bedtime blood glucose measurement for their patients with diabetes. They decided to investigate the issues by using their current staff nurse committee structure. The clinical nurse specialists and nurse education specialists decided to address the issue by educating and engaging the staff in the define, measure, analyze, improve, control (DMAIC) framework process. They found that two issues needed to be improved, including timing of bedtime blood glucose measurement and snack administration and documentation. Several educational interventions were completed and resulted in improved timing of bedtime glucose measurement and bedtime snack documentation. The nurses understood the DMAIC process, and collaboration and cohesion among the medical units was enhanced. Copyright 2014, SLACK Incorporated.

  5. Accounting Control Technology Using SAP: A Case-Based Approach

    ERIC Educational Resources Information Center

    Ragan, Joseph; Puccio, Christopher; Talisesky, Brandon

    2014-01-01

    The Sarbanes-Oxley Act (SOX) revolutionized the accounting and audit industry. The use of preventative and process controls to evaluate the continuous audit process done via an SAP ERP ECC 6.0 system is key to compliance with SOX and managing costs. This paper can be used in a variety of ways to discuss issues associated with auditing and testing…

  6. ALTERNATIVES FOR CLASS A BIOSOLIDS

    EPA Science Inventory

    The presentation reviews the pathogenic microorganisms that may be found in sewage sludge and commonly employed Class A processes for controlling them including advanced digestion, alkaline treatment and heat drying. How extensively the processes are used as well as issues and co...

  7. CONCERNS WITH THE BENEFICIAL REUSE IN AGRICULTURE OF RESIDUALS FROM MUNICIPAL WASTEWATER TREATMENT AND ANIMAL FEEDING OPERATIONS

    EPA Science Inventory

    The pathogenic organisms that may be present in such residuals, processes commonly employed for controlling them; these processes' effectiveness and how extensively they are used; and issues and concerns with beneficial reuse will be discussed. Processes presently being researche...

  8. Compilation Process for the DOD Consolidated Financial Statements for FY 1997.

    DTIC Science & Technology

    1998-09-24

    we issued a disclaimer of opinion on the DoD Consolidated Financial Statements for FY 1997. We issued our reports on internal controls and compliance...with laws and regulations on June 22, 1998. The overall audit objective was to determine whether the DoD Consolidated Financial Statements for FY 1997

  9. Systems Engineering and Integration for Advanced Life Support System and HST

    NASA Technical Reports Server (NTRS)

    Kamarani, Ali K.

    2005-01-01

    Systems engineering (SE) discipline has revolutionized the way engineers and managers think about solving issues related to design of complex systems: With continued development of state-of-the-art technologies, systems are becoming more complex and therefore, a systematic approach is essential to control and manage their integrated design and development. This complexity is driven from integration issues. In this case, subsystems must interact with one another in order to achieve integration objectives, and also achieve the overall system's required performance. Systems engineering process addresses these issues at multiple levels. It is a technology and management process dedicated to controlling all aspects of system life cycle to assure integration at all levels. The Advanced Integration Matrix (AIM) project serves as the systems engineering and integration function for the Human Support Technology (HST) program. AIM provides means for integrated test facilities and personnel for performance trade studies, analyses, integrated models, test results, and validated requirements of the integration of HST. The goal of AIM is to address systems-level integration issues for exploration missions. It will use an incremental systems integration approach to yield technologies, baselines for further development, and possible breakthrough concepts in the areas of technological and organizational interfaces, total information flow, system wide controls, technical synergism, mission operations protocols and procedures, and human-machine interfaces.

  10. 7 CFR 981.442 - Quality control.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., pieces of kernels, meal accumulated in manufacturing, or other material, to crushers, feed manufacturers... contamination in accordance with the provisions of this section. (1) Treatment process. Treatment processes... Salmonella bacteria in almonds, pursuant to a letter of determination issued by the Food and Drug...

  11. 40 CFR 60.21 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... control equipment or process change; and (5) Final compliance. (i) Region means an air quality control... standard of performance for new stationary sources, but for which air quality criteria have not been issued... account the cost of such reduction) the Administrator has determined has been adequately demonstrated for...

  12. Encryption for Remote Control via Internet or Intranet

    NASA Technical Reports Server (NTRS)

    Lineberger, Lewis

    2005-01-01

    A data-communication protocol has been devised to enable secure, reliable remote control of processes and equipment via a collision-based network, while using minimal bandwidth and computation. The network could be the Internet or an intranet. Control is made secure by use of both a password and a dynamic key, which is sent transparently to a remote user by the controlled computer (that is, the computer, located at the site of the equipment or process to be controlled, that exerts direct control over the process). The protocol functions in the presence of network latency, overcomes errors caused by missed dynamic keys, and defeats attempts by unauthorized remote users to gain control. The protocol is not suitable for real-time control, but is well suited for applications in which control latencies up to about 0.5 second are acceptable. The encryption scheme involves the use of both a dynamic and a private key, without any additional overhead that would degrade performance. The dynamic key is embedded in the equipment- or process-monitor data packets sent out by the controlled computer: in other words, the dynamic key is a subset of the data in each such data packet. The controlled computer maintains a history of the last 3 to 5 data packets for use in decrypting incoming control commands. In addition, the controlled computer records a private key (password) that is given to the remote computer. The encrypted incoming command is permuted by both the dynamic and private key. A person who records the command data in a given packet for hostile purposes cannot use that packet after the public key expires (typically within 3 seconds). Even a person in possession of an unauthorized copy of the command/remote-display software cannot use that software in the absence of the password. The use of a dynamic key embedded in the outgoing data makes the central-processing unit overhead very small. The use of a National Instruments DataSocket(TradeMark) (or equivalent) protocol or the User Datagram Protocol makes it possible to obtain reasonably short response times: Typical response times in event-driven control, using packets sized .300 bytes, are <0.2 second for commands issued from locations anywhere on Earth. The protocol requires that control commands represent absolute values of controlled parameters (e.g., a specified temperature), as distinguished from changes in values of controlled parameters (e.g., a specified increment of temperature). Each command is issued three or more times to ensure delivery in crowded networks. The use of absolute-value commands prevents additional (redundant) commands from causing trouble. Because a remote controlling computer receives "talkback" in the form of data packets from the controlled computer, typically within a time interval < or =1 s, the controlling computer can re-issue a command if network failure has occurred. The controlled computer, the process or equipment that it controls, and any human operator(s) at the site of the controlled equipment or process should be equipped with safety measures to prevent damage to equipment or injury to humans. These features could be a combination of software, external hardware, and intervention by the human operator(s). The protocol is not fail-safe, but by adopting these safety measures as part of the protocol, one makes the protocol a robust means of controlling remote processes and equipment by use of typical office computers via intranets and/or the Internet.

  13. Independent Orbiter Assessment (IOA): CIL issues resolution report, volume 1

    NASA Technical Reports Server (NTRS)

    Urbanowicz, Kenneth J.; Hinsdale, L. W.; Barnes, J. E.

    1988-01-01

    The results of the Independent Orbiter Assessment (IOA) of the Failure Modes and Effects Analysis (FMEA) and Critical Items List (CIL) are presented. This report contains IOA assessment worksheets showing resolution of outstanding IOA CIL issues that were summarized in the IOA FMEA/CIL Assessment Interim Report, dated 9 March 1988. Each assessment worksheet has been updated with CIL issue resolution and rationale. The NASA and Prime Contractor post 51-L FMEA/CIL documentation assessed is believed to be technically accurate and complete. No assessment issues remain that has safety implications. Volume 1 contain worksheets for the following sybsystems: Landing and Deceleration Subsystem; Purge, Vent and Drain Subsystem; Active Thermal Control and Life Support Systems; Crew Equipment Subsystem; Instrumentation Subsystem; Data Processing Subsystem; Atmospheric Revitalization Pressure Control Subsystem; Hydraulics and Water Spray Boiler Subsystem; and Mechanical Actuation Subsystem.

  14. Applying Human Factors Evaluation and Design Guidance to a Nuclear Power Plant Digital Control System

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Thomas Ulrich; Ronald Boring; William Phoenix

    2012-08-01

    The United States (U.S.) nuclear industry, like similar process control industries, has moved toward upgrading its control rooms. The upgraded control rooms typically feature digital control system (DCS) displays embedded in the panels. These displays gather information from the system and represent that information on a single display surface. In this manner, the DCS combines many previously separate analog indicators and controls into a single digital display, whereby the operators can toggle between multiple windows to monitor and control different aspects of the plant. The design of the DCS depends on the function of the system it monitors, but revolvesmore » around presenting the information most germane to an operator at any point in time. DCSs require a carefully designed human system interface. This report centers on redesigning existing DCS displays for an example chemical volume control system (CVCS) at a U.S. nuclear power plant. The crucial nature of the CVCS, which controls coolant levels and boration in the primary system, requires a thorough human factors evaluation of its supporting DCS. The initial digital controls being developed for the DCSs tend to directly mimic the former analog controls. There are, however, unique operator interactions with a digital vs. analog interface, and the differences have not always been carefully factored in the translation of an analog interface to a replacement DCS. To ensure safety, efficiency, and usability of the emerging DCSs, a human factors usability evaluation was conducted on a CVCS DCS currently being used and refined at an existing U.S. nuclear power plant. Subject matter experts from process control engineering, software development, and human factors evaluated the DCS displays to document potential usability issues and propose design recommendations. The evaluation yielded 167 potential usability issues with the DCS. These issues should not be considered operator performance problems but rather opportunities identified by experts to improve upon the design of the DCS. A set of nine design recommendations was developed to address these potential issues. The design principles addressed the following areas: (1) color, (2) pop-up window structure, (3) navigation, (4) alarms, (5) process control diagram, (6) gestalt grouping, (7) typography, (8) terminology, and (9) data entry. Visuals illustrating the improved DCS displays accompany the design recommendations. These nine design principles serve as the starting point to a planned general DCS style guide that can be used across the U.S. nuclear industry to aid in the future design of effective DCS interfaces.« less

  15. The Multilingual Lexicon: Modelling Selection and Control

    ERIC Educational Resources Information Center

    de Bot, Kees

    2004-01-01

    In this paper an overview of research on the multilingual lexicon is presented as the basis for a model for processing multiple languages. With respect to specific issues relating to the processing of more than two languages, it is suggested that there is no need to develop a specific model for such multilingual processing, but at the same time we…

  16. Emotion-Related Self-Regulation in Children

    ERIC Educational Resources Information Center

    Eisenberg, Nancy; Sulik, Michael J.

    2012-01-01

    In this article, the authors review basic conceptual issues in research on children's emotion-related self-regulation, including the differentiation between self-regulation that is effortful and voluntary and control-related processes that are less amenable to effortful control. In addition, the authors summarize what researchers know about…

  17. Issues in human/computer control of dexterous remote hands

    NASA Technical Reports Server (NTRS)

    Salisbury, K.

    1987-01-01

    Much research on dexterous robot hands has been aimed at the design and control problems associated with their autonomous operation, while relatively little research has addressed the problem of direct human control. It is likely that these two modes can be combined in a complementary manner yielding more capability than either alone could provide. While many of the issues in mixed computer/human control of dexterous hands parallel those found in supervisory control of traditional remote manipulators, the unique geometry and capabilities of dexterous hands pose many new problems. Among these are the control of redundant degrees of freedom, grasp stabilization and specification of non-anthropomorphic behavior. An overview is given of progress made at the MIT AI Laboratory in control of the Salisbury 3 finger hand, including experiments in grasp planning and manipulation via controlled slip. It is also suggested how we might introduce human control into the process at a variety of functional levels.

  18. A Hypertext-Based Computer Architecture for Management of the Joint Command, Control and Communications Curriculum

    DTIC Science & Technology

    1992-06-01

    Boards) Security, Privacy, and Freedom of Speech Issues 4.1.2 Understand the relationships between information processing and collection and...to-many (Mailing and discussion Lists) ... Many-to-Many (Bulletin Boards) Security, Privacy, and Freedom of Speech Issues 69 4.1.3 Understand the...Communication one-to-one (e-mail) °o° one-to-many (Mailing and discussion Lists) ... Many-to-Many (Bulletin Boards) oo Security, Privacy, and Freedom of Speech Issues

  19. Environmental Impact Analysis Process. Final Environmental Impact Statement for Expansion of the Melrose Air Force Range, Curry and Roosevelt Counties, New Mexico

    DTIC Science & Technology

    1985-04-18

    discuss very briefly the logic, or substance, of the issues in this possible decision--why it might not be logical. And, third, the moral , or ethical...o’f the issue - authors advocating measurable effect and those indicating no effect. 38 CHABA has taken the position that current evidence is suggestive...but it does not provide definitive answers on the long-term health effect issue . CHABA encourages more definitive research with adequate controls

  20. Practical Use of Operation Data in the Process Industry

    NASA Astrophysics Data System (ADS)

    Kano, Manabu

    This paper aims to reveal real problems in the process industry and introduce recent development to solve such problems from the viewpoint of effective use of operation data. Two topics are discussed: virtual sensor and process control. First, in order to clarify the present state and problems, a part of our recent questionnaire survey of process control is quoted. It is emphasized that maintenance is a key issue not only for soft-sensors but also for controllers. Then, new techniques are explained. The first one is correlation-based just-in-time modeling (CoJIT), which can realize higher prediction performance than conventional methods and simplify model maintenance. The second is extended fictitious reference iterative tuning (E-FRIT), which can realize data-driven PID control parameter tuning without process modeling. The great usefulness of these techniques are demonstrated through their industrial applications.

  1. System Engineering and Integration of Controls for Advanced Life Support

    NASA Technical Reports Server (NTRS)

    Overland, David; Hoo, Karlene; Ciskowski, Marvin

    2006-01-01

    The Advanced Integration Matrix (AIM) project at the Johnson Space Center (JSC) was chartered to study and solve systems-level integration issues for exploration missions. One of the first issues identified was an inability to conduct trade studies on control system architectures due to the absence of mature evaluation criteria. Such architectures are necessary to enable integration of regenerative life support systems. A team was formed to address issues concerning software and hardware architectures and system controls.. The team has investigated what is required to integrate controls for the types of non-linear dynamic systems encountered in advanced life support. To this end, a water processing bioreactor testbed is being developed which will enable prototyping and testing of integration strategies and technologies. Although systems such as the water bioreactors exhibit the complexities of interactions between control schemes most vividly, it is apparent that this behavior and its attendant risks will manifest itself among any set of interdependent autonomous control systems. A methodology for developing integration requirements for interdependent and autonomous systems is a goal of this team and this testbed. This paper is a high-level summary of the current status of the investigation, the issues encountered, some tentative conclusions, and the direction expected for further research.

  2. Puppets, robots, critics, and actors within a taxonomy of attention for developmental disorders

    PubMed Central

    DENNIS, MAUREEN; SINOPOLI, KATIA J.; FLETCHER, JACK M.; SCHACHAR, RUSSELL

    2008-01-01

    This review proposes a new taxonomy of automatic and controlled attention. The taxonomy distinguishes among the role of the attendee (puppet and robot, critic and actor), the attention process (stimulus orienting vs. response control), and the attention operation (activation vs. inhibition vs. adjustment), and identifies cognitive phenotypes by which attention is overtly expressed. We apply the taxonomy to four childhood attention disorders: attention deficit hyperactivity disorder, spina bifida meningomyelocele, traumatic brain injury, and acute lymphoblastic leukemia. Variations in attention are related to specific brain regions that support normal attention processes when intact, and produce disordered attention when impaired. The taxonomy explains group differences in behavioral inattention, hyperactivity, and impulsiveness, as well as medication response. We also discuss issues relevant to theories of the cognitive and neural architecture of attention: functional dissociations within and between automatic and controlled attention; the relative importance of type of brain damage and developmental timing to attention profile; cognitive-energetic models of attention and white matter damage; temporal processing deficits, attention deficits and cerebellar damage; and the issue of cognitive phenotypes as candidate endophenotypes. PMID:18764966

  3. A Framework for WWW Query Processing

    NASA Technical Reports Server (NTRS)

    Wu, Binghui Helen; Wharton, Stephen (Technical Monitor)

    2000-01-01

    Query processing is the most common operation in a DBMS. Sophisticated query processing has been mainly targeted at a single enterprise environment providing centralized control over data and metadata. Submitting queries by anonymous users on the web is different in such a way that load balancing or DBMS' accessing control becomes the key issue. This paper provides a solution by introducing a framework for WWW query processing. The success of this framework lies in the utilization of query optimization techniques and the ontological approach. This methodology has proved to be cost effective at the NASA Goddard Space Flight Center Distributed Active Archive Center (GDAAC).

  4. Method of synchronizing independent functional unit

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kim, Changhoan

    A system for synchronizing parallel processing of a plurality of functional processing units (FPU), a first FPU and a first program counter to control timing of a first stream of program instructions issued to the first FPU by advancement of the first program counter; a second FPU and a second program counter to control timing of a second stream of program instructions issued to the second FPU by advancement of the second program counter, the first FPU is in communication with a second FPU to synchronize the issuance of a first stream of program instructions to the second stream ofmore » program instructions and the second FPU is in communication with the first FPU to synchronize the issuance of the second stream program instructions to the first stream of program instructions.« less

  5. Method of synchronizing independent functional unit

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kim, Changhoan

    2017-05-16

    A system for synchronizing parallel processing of a plurality of functional processing units (FPU), a first FPU and a first program counter to control timing of a first stream of program instructions issued to the first FPU by advancement of the first program counter; a second FPU and a second program counter to control timing of a second stream of program instructions issued to the second FPU by advancement of the second program counter, the first FPU is in communication with a second FPU to synchronize the issuance of a first stream of program instructions to the second stream ofmore » program instructions and the second FPU is in communication with the first FPU to synchronize the issuance of the second stream program instructions to the first stream of program instructions.« less

  6. Method of synchronizing independent functional unit

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kim, Changhoan

    2017-02-14

    A system for synchronizing parallel processing of a plurality of functional processing units (FPU), a first FPU and a first program counter to control timing of a first stream of program instructions issued to the first FPU by advancement of the first program counter; a second FPU and a second program counter to control timing of a second stream of program instructions issued to the second FPU by advancement of the second program counter, the first FPU is in communication with a second FPU to synchronize the issuance of a first stream of program instructions to the second stream ofmore » program instructions and the second FPU is in communication with the first FPU to synchronize the issuance of the second stream program instructions to the first stream of program instructions.« less

  7. The utilization of six sigma and statistical process control techniques in surgical quality improvement.

    PubMed

    Sedlack, Jeffrey D

    2010-01-01

    Surgeons have been slow to incorporate industrial reliability techniques. Process control methods were applied to surgeon waiting time between cases, and to length of stay (LOS) after colon surgery. Waiting times between surgeries were evaluated by auditing the operating room records of a single hospital over a 1-month period. The medical records of 628 patients undergoing colon surgery over a 5-year period were reviewed. The average surgeon wait time between cases was 53 min, and the busiest surgeon spent 291/2 hr in 1 month waiting between surgeries. Process control charting demonstrated poor overall control of the room turnover process. Average LOS after colon resection also demonstrated very poor control. Mean LOS was 10 days. Weibull's conditional analysis revealed a conditional LOS of 9.83 days. Serious process management problems were identified in both analyses. These process issues are both expensive and adversely affect the quality of service offered by the institution. Process control mechanisms were suggested or implemented to improve these surgical processes. Industrial reliability and quality management tools can easily and effectively identify process control problems that occur on surgical services. © 2010 National Association for Healthcare Quality.

  8. Badging people not on your payroll.

    PubMed

    Hogan, Mary Alice

    2009-01-01

    A complex badging process to create a culture of safety in a medical center is described by the author. Badging is not only used to control access by employees, but non-employees--medical students, vendors, contractors, volunteers, etc.--are subjected to similar processing procedures before they can be issued badges.

  9. Intuition, Reason, and Metacognition

    ERIC Educational Resources Information Center

    Thompson, Valerie A.; Prowse Turner, Jamie A.; Pennycook, Gordon

    2011-01-01

    Dual Process Theories (DPT) of reasoning posit that judgments are mediated by both fast, automatic processes and more deliberate, analytic ones. A critical, but unanswered question concerns the issue of monitoring and control: When do reasoners rely on the first, intuitive output and when do they engage more effortful thinking? We hypothesised…

  10. Issues of Teaching Metrology in Higher Education Institutions of Civil Engineering in Russia

    ERIC Educational Resources Information Center

    Pukharenko, Yurii Vladimirovich; Norin, Veniamin Aleksandrovich

    2017-01-01

    The work analyses the training process condition in teaching the discipline "Metrology, Standardization, Certification and Quality Control." It proves that the current educational standard regarding the instruction of the discipline "Metrology, Standardization, Certification and Quality Control" does not meet the needs of the…

  11. Welding wire selection critical to jet engine repair work

    NASA Astrophysics Data System (ADS)

    1992-11-01

    A review is provided of issues related to the selection of welding wire for aircraft gas-turbine engines emphasizing the importance of cleanliness in the welding wire product. A three-step metallurgical control process is described for the production of welding wire that is clean and suitable for turbine repair. The process is based on: (1) vacuum induction melting; (2) contamination-free processing of the wire; and (3) environmentally controlled packaging. Weld work on aerospace casting is shown to be useful and suitable for many alloy and superalloy materials with various filler materials.

  12. Research priorities for tobacco control in developing countries: a regional approach to a global consultative process

    PubMed Central

    Baris, E.; Brigden, L. W.; Prindiville, J.; e, S; Chitanondh, H.; Chandiwana, S.

    2000-01-01

    OBJECTIVE—To develop regional tobacco control research agendas for developing countries through a consultative process.
METHODS—Research for International Tobacco Control, located at the International Development Research Centre in Ottawa, Canada, convened three regional meetings for Latin America and the Caribbean, South and Southeast Asia, and Eastern, Central and Southern Africa. Participation by researchers, policymakers, and advocates from a wide range of disciplines ensured an accurate representation of regional issues.
RESULTS—The four main recurring themes within each regional agenda were: (1) the lack of standardised and comparable data; (2) the absence of a network for communication of information, data, and best practices; (3) a lack of adequate capacity for tobacco control research, especially in non-health related areas such as economics and policy analysis; and (4) a need for concerted mobilisation of human and financial resources in order to implement a comprehensive research agenda, build partnerships, and stimulate comparative research and analysis. Specific research issues included the need for descriptive data with respect to the supply side of the tobacco equation, and analytical data related to tobacco use, production and marketing, and taxation.
CONCLUSIONS—There was a uniform perception of tobacco as a multidisciplinary issue. All regional agendas included a balance of health, economic, agricultural, environmental, sociocultural, and international trade concerns. Research data are urgently required to provide a sound basis for the development of tobacco control policies and programmes. As tobacco control takes its rightful place on the global health agenda, it is vital that funding for tobacco control research be increased.


Keywords: regional tobacco control programmes; developing countries; tobacco control research PMID:10841859

  13. Adolescents' as active agents in the socialization process: legitimacy of parental authority and obligation to obey as predictors of obedience.

    PubMed

    Darling, Nancy; Cumsille, Patricio; Martínez, M Loreto

    2007-04-01

    Adolescents' agreement with parental standards and beliefs about the legitimacy of parental authority and their own obligation to obey were used to predict adolescents' obedience, controlling for parental monitoring, rules, and rule enforcement. Hierarchical linear models were used to predict both between-adolescent and within-adolescent, issue-specific differences in obedience in a sample of 703 Chilean adolescents (M age=15.0 years). Adolescents' global agreement with parents and global beliefs about their obligation to obey predicted between-adolescent obedience, controlling for parental monitoring, age, and gender. Adolescents' issue-specific agreement, legitimacy beliefs, and obligation to obey predicted issue-specific obedience, controlling for rules and parents' reports of rule enforcement. The potential of examining adolescents' agreement and beliefs about authority as a key link between parenting practices and adolescents' decisions to obey is discussed.

  14. Using Biodata to Select Air Traffic Controllers

    DTIC Science & Technology

    2014-10-01

    training success (Collins et al., 1990). In fact, in a study designed specifically to address the impact of education on controller suc- cess, defined...examination of adverse impact in controller selection for certain protected groups in controller selection. The concern was the use of the AT-SAT in...Broach et al., 2013). The issue is how to reduce adverse impact in controller hiring and still maintain a valid process for selecting the best

  15. Using OPC technology to support the study of advanced process control.

    PubMed

    Mahmoud, Magdi S; Sabih, Muhammad; Elshafei, Moustafa

    2015-03-01

    OPC, originally the Object Linking and Embedding (OLE) for Process Control, brings a broad communication opportunity between different kinds of control systems. This paper investigates the use of OPC technology for the study of distributed control systems (DCS) as a cost effective and flexible research tool for the development and testing of advanced process control (APC) techniques in university research centers. Co-Simulation environment based on Matlab, LabVIEW and TCP/IP network is presented here. Several implementation issues and OPC based client/server control application have been addressed for TCP/IP network. A nonlinear boiler model is simulated as OPC server and OPC client is used for closed loop model identification, and to design a Model Predictive Controller. The MPC is able to control the NOx emissions in addition to drum water level and steam pressure. Copyright © 2014 ISA. Published by Elsevier Ltd. All rights reserved.

  16. Anaerobic digestion of food waste: A review focusing on process stability.

    PubMed

    Li, Lei; Peng, Xuya; Wang, Xiaoming; Wu, Di

    2018-01-01

    Food waste (FW) is rich in biomass energy, and increasing numbers of national programs are being established to recover energy from FW using anaerobic digestion (AD). However process instability is a common operational issue for AD of FW. Process monitoring and control as well as microbial management can be used to control instability and increase the energy conversion efficiency of anaerobic digesters. Here, we review research progress related to these methods and identify existing limitations to efficient AD; recommendations for future research are also discussed. Process monitoring and control are suitable for evaluating the current operational status of digesters, whereas microbial management can facilitate early diagnosis and process optimization. Optimizing and combining these two methods are necessary to improve AD efficiency. Copyright © 2017 Elsevier Ltd. All rights reserved.

  17. Programming, budgeting, and control in health care organization: the state of the art.

    PubMed Central

    Vraciu, R A

    1979-01-01

    The planning, budgeting, and controlling processes (PBCP) largely subsume all of the planning and controlling activities of an organization. This paper discusses these activities within the context of a single management control system, focusing on three topics. First, a brief historical perspective of management concerns which relate to PBCP is presented and several important external pressures currently imposed on the health care industry are discussed. Second, normative models of the processes--programming, budgeting, and controlling--are presented. The discussion focuses on the elements and relationships of these processes, and numerous references to the literature are provided. Third, several issues related to the gap between the state of the art in PBCP for hospitals and the current state of practice are discussed. PMID:116990

  18. Weighing in on the Issue: A Longitudinal Analysis of the Influence of Selected Individual Factors and the Sports Context on the Developmental Trajectories of Eating Pathology among Adolescents

    ERIC Educational Resources Information Center

    Fay, Kristen; Lerner, Richard M.

    2013-01-01

    Eating disorders, and related issues (e.g., body dissatisfaction, weight control behaviors), represent pressing and prevalent health problems that affect American adolescents with alarming frequency and potentially chronic consequences. However, more longitudinal research is needed to elucidate the developmental processes that increase or maintain…

  19. Interactions Between Structure and Processing that Control Moisture Uptake in High-Performance Polycyanurates (Briefing Charts)

    DTIC Science & Technology

    2015-03-24

    distribution is unlimited.  . Interactions Between Structure and Processing that Control Moisture Uptake in High-Performance Polycyanurates Presenter: Dr...Edwards AFB, CA 4 California State University, Long Beach, CA 90840 2 Outline: Basic Studies of Moisture Uptake in Cyanate Ester Networks • Background...Motivation • SOTA Theories of Moisture Uptake in Thermosetting Networks • New Tools and New Discoveries • Unresolved Issues and Ways to Address Them

  20. A neuro-data envelopment analysis approach for optimization of uncorrelated multiple response problems with smaller the better type controllable factors

    NASA Astrophysics Data System (ADS)

    Bashiri, Mahdi; Farshbaf-Geranmayeh, Amir; Mogouie, Hamed

    2013-11-01

    In this paper, a new method is proposed to optimize a multi-response optimization problem based on the Taguchi method for the processes where controllable factors are the smaller-the-better (STB)-type variables and the analyzer desires to find an optimal solution with smaller amount of controllable factors. In such processes, the overall output quality of the product should be maximized while the usage of the process inputs, the controllable factors, should be minimized. Since all possible combinations of factors' levels, are not considered in the Taguchi method, the response values of the possible unpracticed treatments are estimated using the artificial neural network (ANN). The neural network is tuned by the central composite design (CCD) and the genetic algorithm (GA). Then data envelopment analysis (DEA) is applied for determining the efficiency of each treatment. Although the important issue for implementation of DEA is its philosophy, which is maximization of outputs versus minimization of inputs, this important issue has been neglected in previous similar studies in multi-response problems. Finally, the most efficient treatment is determined using the maximin weight model approach. The performance of the proposed method is verified in a plastic molding process. Moreover a sensitivity analysis has been done by an efficiency estimator neural network. The results show efficiency of the proposed approach.

  1. Acute stress affects prospective memory functions via associative memory processes.

    PubMed

    Szőllősi, Ágnes; Pajkossy, Péter; Demeter, Gyula; Kéri, Szabolcs; Racsmány, Mihály

    2018-01-01

    Recent findings suggest that acute stress can improve the execution of delayed intentions (prospective memory, PM). However, it is unclear whether this improvement can be explained by altered executive control processes or by altered associative memory functioning. To investigate this issue, we used physical-psychosocial stressors to induce acute stress in laboratory settings. Then participants completed event- and time-based PM tasks requiring the different contribution of control processes and a control task (letter fluency) frequently used to measure executive functions. According to our results, acute stress had no impact on ongoing task performance, time-based PM, and verbal fluency, whereas it enhanced event-based PM as measured by response speed for the prospective cues. Our findings indicate that, here, acute stress did not affect executive control processes. We suggest that stress affected event-based PM via associative memory processes. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. Preface to the special issue on "Integrated Microwave Photonic Signal Processing"

    NASA Astrophysics Data System (ADS)

    Azaña, José; Yao, Jianping

    2016-08-01

    As Guest Editors, we are pleased to introduce this special issue on ;Integrated Microwave Photonic Signal Processing; published by the Elsevier journal Optics Communications. Microwave photonics is a field of growing importance from both scientific and practical application perspectives. The field of microwave photonics is devoted to the study, development and application of optics-based techniques and technologies aimed to the generation, processing, control, characterization and/or distribution of microwave signals, including signals well into the millimeter-wave frequency range. The use of photonic technologies for these microwave applications translates into a number of key advantages, such as the possibility of dealing with high-frequency, wide bandwidth signals with minimal losses and reduced electromagnetic interferences, and the potential for enhanced reconfigurability. The central purpose of this special issue is to provide an overview of the state of the art of generation, processing and characterization technologies for high-frequency microwave signals. It is now widely accepted that the practical success of microwave photonics at a large scale will essentially depend on the realization of high-performance microwave-photonic signal-processing engines in compact and integrated formats, preferably on a chip. Thus, the focus of the issue is on techniques implemented using integrated photonic technologies, with the goal of providing an update of the most recent advances toward realization of this vision.

  3. Weathering and landscape evolution

    NASA Astrophysics Data System (ADS)

    Turkington, Alice V.; Phillips, Jonathan D.; Campbell, Sean W.

    2005-04-01

    In recognition of the fundamental control exerted by weathering on landscape evolution and topographic development, the 35th Binghamton Geomorphology Symposium was convened under the theme of Weathering and Landscape Evolution. The papers and posters presented at the conference imparted the state-of-the-art in weathering geomorphology, tackled the issue of scale linkage in geomorphic studies and offered a vehicle for interdisciplinary communication on research into weathering and landscape evolution. The papers included in this special issue are encapsulated here under the general themes of weathering mantles, weathering and relative dating, weathering and denudation, weathering processes and controls and the 'big picture'.

  4. A model for the control mode man-computer interface dialogue

    NASA Technical Reports Server (NTRS)

    Chafin, R. L.

    1981-01-01

    A four stage model is presented for the control mode man-computer interface dialogue. It consists of context development, semantic development syntactic development, and command execution. Each stage is discussed in terms of the operator skill levels (naive, novice, competent, and expert) and pertinent human factors issues. These issues are human problem solving, human memory, and schemata. The execution stage is discussed in terms of the operators typing skills. This model provides an understanding of the human process in command mode activity for computer systems and a foundation for relating system characteristics to operator characteristics.

  5. Evaluation of Chemical Coating Processes for AXAF

    NASA Technical Reports Server (NTRS)

    Engelhaupt, Darell E.

    1997-01-01

    The need existed at MSFC for the development and fabrication of radioisotope calibration sources of cadmium 109 and iron 55 isotopes. This was in urgent response to the AXAF program. Several issues persisted in creating manufacturing difficulties for the supplier. In order to meet the MSFC requirements very stringent control needed to be maintained for the coating quality, specific activity and thickness. Due to the difficulties in providing the precisely controlled devices for testing, the delivery of the sources was seriously delayed. It became imperative that these fabrication issues be resolved to avoid further delays in this AXAF observatory key component.

  6. On the meaning of meaning when being mean: commentary on Berkowitz's "on the consideration of automatic as well as controlled psychological processes in aggression".

    PubMed

    Dodge, Kenneth A

    2008-01-01

    Berkowitz (this issue) makes a cogent case for his cognitive neo-associationist (CNA) model that some aggressive behaviors occur automatically, emotionally, and through conditioned association with other stimuli. He also proposes that they can occur without "processing," that is, without meaning. He contrasts his position with that of social information processing (SIP) models, which he casts as positing only controlled processing mechanisms for aggressive behavior. However, both CNA and SIP models posit automatic as well as controlled processes in aggressive behavior. Most aggressive behaviors occur through automatic processes, which are nonetheless rule governed. SIP models differ from the CNA model in asserting the essential role of meaning (often through nonconscious, automatic, and emotional processes) in mediating the link between a stimulus and an angry aggressive behavioral response. Copyright 2008 Wiley-Liss, Inc.

  7. Classification Trees for Quality Control Processes in Automated Constructed Response Scoring.

    ERIC Educational Resources Information Center

    Williamson, David M.; Hone, Anne S.; Miller, Susan; Bejar, Isaac I.

    As the automated scoring of constructed responses reaches operational status, the issue of monitoring the scoring process becomes a primary concern, particularly when the goal is to have automated scoring operate completely unassisted by humans. Using a vignette from the Architectural Registration Examination and data for 326 cases with both human…

  8. Contextual Modulation of N400 Amplitude to Lexically Ambiguous Words

    ERIC Educational Resources Information Center

    Titone, Debra A.; Salisbury, Dean F.

    2004-01-01

    Through much is known about the N400 component, an event-related EEG potential that is sensitive to semantic manipulations, it is unclear whether modulations of N400 amplitude reflect automatic processing, controlled processing, or both. We examined this issue using a semantic judgment task that manipulated local and global contextual cues. Word…

  9. Operational Test and Evaluation Handbook for Aircrew Training Devices. Volume I. Planning and Management.

    DTIC Science & Technology

    1982-02-01

    of i, nd to (! Lvel op an awareness of the T&E roles and responsioi Ii ties Viir~dte various Air Force organizations involved in the T&EC process... mathematical models to determine controller messages and issue controller messages using computer generated speech. AUTOMATED PERFORMANCE ALERTS: Signals

  10. 77 FR 34046 - Advisory Committee to the Director (ACD), Centers for Disease Control and Prevention (CDC)-Ethics...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-08

    ... Committee to the Director (ACD), Centers for Disease Control and Prevention (CDC)--Ethics Subcommittee (ES... ACD, CDC, regarding a broad range of public health ethics questions and issues arising from programs... ethics standards to the accreditation process for public health departments; ethical considerations...

  11. A parallel expert system for the control of a robotic air vehicle

    NASA Technical Reports Server (NTRS)

    Shakley, Donald; Lamont, Gary B.

    1988-01-01

    Expert systems can be used to govern the intelligent control of vehicles, for example the Robotic Air Vehicle (RAV). Due to the nature of the RAV system the associated expert system needs to perform in a demanding real-time environment. The use of a parallel processing capability to support the associated expert system's computational requirement is critical in this application. Thus, algorithms for parallel real-time expert systems must be designed, analyzed, and synthesized. The design process incorporates a consideration of the rule-set/face-set size along with representation issues. These issues are looked at in reference to information movement and various inference mechanisms. Also examined is the process involved with transporting the RAV expert system functions from the TI Explorer, where they are implemented in the Automated Reasoning Tool (ART), to the iPSC Hypercube, where the system is synthesized using Concurrent Common LISP (CCLISP). The transformation process for the ART to CCLISP conversion is described. The performance characteristics of the parallel implementation of these expert systems on the iPSC Hypercube are compared to the TI Explorer implementation.

  12. Energy issues in microwave food processing: A review of developments and the enabling potentials of solid-state power delivery.

    PubMed

    Atuonwu, J C; Tassou, S A

    2018-01-23

    The enormous magnitude and variety of microwave applications in household, commercial and industrial food processing creates a strong motivation for improving the energy efficiency and hence, sustainability of the process. This review critically assesses key energy issues associated with microwave food processing, focusing on previous energy performance studies, energy performance metrics, standards and regulations. Factors affecting energy-efficiency are categorised into source, load and source-load matching factors. This highlights the need for highly-flexible and controllable power sources capable of receiving real-time feedback on load properties, and effecting rapid control actions to minimise reflections, heating non-uniformities and other imperfections that lead to energy losses. A case is made for the use of solid-state amplifiers as alternatives to conventional power sources, magnetrons. By a full-scale techno-economic analysis, including energy aspects, it is shown that the use of solid-state amplifiers as replacements to magnetrons is promising, not only from an energy and overall technical perspective, but also in terms of economics.

  13. To naturalize or not to naturalize? An issue for cognitive science as well as anthropology.

    PubMed

    Stenning, Keith

    2012-07-01

    Several of Beller, Bender, and Medin's (2012) issues are as relevant within cognitive science as between it and anthropology. Knowledge-rich human mental processes impose hermeneutic tasks, both on subjects and researchers. Psychology's current philosophy of science is ill suited to analyzing these: Its demand for ''stimulus control'' needs to give way to ''negotiation of mutual interpretation.'' Cognitive science has ways to address these issues, as does anthropology. An example from my own work is about how defeasible logics are mathematical models of some aspects of simple hermeneutic processes. They explain processing relative to databases of knowledge and belief-that is, content. A specific example is syllogistic reasoning, which raises issues of experimenters' interpretations of subjects' reasoning. Science, especially since the advent of understandings of computation, does not have to be reductive. How does this approach transfer onto anthropological topics? Recent cognitive science approaches to anthropological topics have taken a reductive stance in terms of modules. We end with some speculations about a different cognitive approach to, for example, religion. Copyright © 2012 Cognitive Science Society, Inc.

  14. Evaluation of Chemical Coating Processes for AXAF

    NASA Technical Reports Server (NTRS)

    Engelhaupt, Darell; Ramsey, Brian; Mendrek, Mitchell

    1998-01-01

    The need existed at MSFC for the development and fabrication of radioisotope calibration sources of cadmium 109 and iron 55 isotopes. This was in urgent response to the AXA-F program. Several issues persisted in creating manufacturing difficulties for the supplier. In order to meet the MSFC requirements very stringent control needed to be maintained for the coating quality, specific activity and thickness. Due to the difficulties in providing the precisely controlled devices for testing, the delivery of the sources was seriously delayed. It became imperative that these fabrication issues be resolved to avoid further delays in this AXA-F observatory key component. The objectives are: 1) Research and provide expert advice on coating materials and procedures. 2) Research and recommend solutions to problems that have been experienced with the coating process. 3) Provide recommendations on the selection and preparation of substrates. 4) Provide consultation on the actual coating process including the results of the qualification and acceptance test programs. 5) Perform independent tests at UAH or MSFC as necessary.

  15. Application of parameter estimation to aircraft stability and control: The output-error approach

    NASA Technical Reports Server (NTRS)

    Maine, Richard E.; Iliff, Kenneth W.

    1986-01-01

    The practical application of parameter estimation methodology to the problem of estimating aircraft stability and control derivatives from flight test data is examined. The primary purpose of the document is to present a comprehensive and unified picture of the entire parameter estimation process and its integration into a flight test program. The document concentrates on the output-error method to provide a focus for detailed examination and to allow us to give specific examples of situations that have arisen. The document first derives the aircraft equations of motion in a form suitable for application to estimation of stability and control derivatives. It then discusses the issues that arise in adapting the equations to the limitations of analysis programs, using a specific program for an example. The roles and issues relating to mass distribution data, preflight predictions, maneuver design, flight scheduling, instrumentation sensors, data acquisition systems, and data processing are then addressed. Finally, the document discusses evaluation and the use of the analysis results.

  16. Daily Readiness Huddles in Radiology-Improving Communication, Coordination, and Problem-Solving Reliability.

    PubMed

    Donnelly, Lane F

    Deploying an intentional daily management process is a key part to create high-reliability culture. Key components described in the literature for a successfully daily management process include leadership standard work, visual controls, daily accountability processes, and the discipline to stick to the process over the long term. We believe that the institution of a daily readiness huddle has helped us better coordinate and communicate as a department and improved our ability to deliver imaging services on a daily basis. The daily readiness huddle has enabled us to more rapidly identify issues and has brought accountability to seeing solutions to those issues brought to fruition. In addition, it has helped with team building, including between the radiologists and the nonphysician staff. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. Crosscultural Issues in the Process of Sending U.S. Employees of Multinational Corporations for Overseas Service: Theoretical Considerations with Practical Implications.

    ERIC Educational Resources Information Center

    Griffis, Betty Ann

    Defining the multinational as a producing enterprise motivated by profit and owning or controlling facilities in more than one country, this paper analyzes the process employed by United States multinationals in sending parent country nationals abroad for service in a subsidiary. It first examines the process in its fullest form by citing…

  18. [How to adapt to the requirements of "clinical value-oriented drug innovation" for pharmaceutical research in application process of new traditional Chinese medicine].

    PubMed

    Jin, Fang

    2017-05-01

    On August 9, 2015, the State Council promulgated the "Opinions of the State Council on the reform of drug and medical device review and approval system" (Guofa 2015 No. 44), and established the "clinical value-oriented drug innovation" model to encourage the research and development of new drugs. Following that, China Food and Drug Administration (CFDA) promulgated the "Notice on several policies for drug registration review and approval" (2015 No. 230 ) on November 11, 2015, clearly specifying that CFDA would "implement one-time approval for clinical trials application of the new drugs, and no longer take a phased declaration, review and approval system; for the new drugs that apply for clinical trials, mainly review the scientific natureof the clinical protocols and the risk control of the new drugs to guarantee the safety of subjects". Accordingly, the evaluation ideas and forms of new drug registration have also been adjusted greatly. For example, issues like the rationality of the drug manufacturing process, whether the scale can reflect the stability of the process, whether the preparation process is sufficient, and whether the choice of dosage form is reasonable are no longer the focus of evaluation before clinical trials. Issues regarding whether the preparation process design is reasonable, whether the effective components can be transferred to the preparation to a maximum extent, whether the process parameters determined in small and middle pilot trials can adapt to the requirements of mass production, no longer act as the reasons for refusing the clinical trials. The corresponding risks shall be borne by the applicant as the subject of liability. The focus in registration evaluation is mainly transferred to how to ensure the consistence of quality between clinical trial samples and the samples already available on market by guaranteeing stable sources of drug raw materials and stable quality of medicines as well as control of the whole preparation process. These issues run through the whole process of new drug development, but also have different focuses in different stages. According to the "Measures on communicating about drug research and development and technical review" (2016 No. 94) (On Trial) issued by CFDA on June 2, 2016, the applicants may communicate with the drug evaluation center in different phases in the process of new drugs registration in respects of medicine material problems, technological problems, and quality control of the preparations. In this paper, the transformation of Chinese medicine research model was described mainly in the following aspects: how to control the quality of medicines from origins, technology design of the preparation and technology process research, and how to establish whole-process quality system. The paper also reflects the concept that the quality of new Chinese drugs research and development comes from design. Copyright© by the Chinese Pharmaceutical Association.

  19. Current issues and problems in welding science

    NASA Astrophysics Data System (ADS)

    David, S. A.; Debroy, T.

    1992-07-01

    Recent advances in welding science are examined with consideration given to the progress made in understanding physical processes of welding and in understanding weldment microstructure and properties and the correlation between microstructure and properties of the welds. Particular attention is given to the methods used for intelligent control and automation of welding. Also discussed are issues and problems that were brought to the surface by technological advances and interdisciplinary research on welding.

  20. In-plant control applications and their effect on treatability of a textile mill wastewater.

    PubMed

    Dulkadiroglu, H; Eremektar, G; Dogruel, S; Uner, H; Germirli-Babuna, F; Orhon, D

    2002-01-01

    Water minimization and exploration of the potential for wastewater recovery and reuse are priority issues of industrial wastewater management. They are extremely significant for the textile industry commonly characterized with a high water demand. The study presents a detailed in-plant control survey for a wool finishing plant. A comprehensive process profile and wastewater characterization indicate that process water consumption can be reduced by 34%, and 23% of the wastewater volume can be recovered for reuse. Treatability of reusable wastewater fraction and the effect of in-plant control applications on effluent treatability were also investigated.

  1. Neural responses to facial expressions support the role of the amygdala in processing threat

    PubMed Central

    Sormaz, Mladen; Flack, Tessa; Asghar, Aziz U. R.; Fan, Siyan; Frey, Julia; Manssuer, Luis; Usten, Deniz; Young, Andrew W.; Andrews, Timothy J.

    2014-01-01

    The amygdala is known to play an important role in the response to facial expressions that convey fear. However, it remains unclear whether the amygdala’s response to fear reflects its role in the interpretation of danger and threat, or whether it is to some extent activated by all facial expressions of emotion. Previous attempts to address this issue using neuroimaging have been confounded by differences in the use of control stimuli across studies. Here, we address this issue using a block design functional magnetic resonance imaging paradigm, in which we compared the response to face images posing expressions of fear, anger, happiness, disgust and sadness with a range of control conditions. The responses in the amygdala to different facial expressions were compared with the responses to a non-face condition (buildings), to mildly happy faces and to neutral faces. Results showed that only fear and anger elicited significantly greater responses compared with the control conditions involving faces. Overall, these findings are consistent with the role of the amygdala in processing threat, rather than in the processing of all facial expressions of emotion, and demonstrate the critical importance of the choice of comparison condition to the pattern of results. PMID:24097376

  2. Validation of gamma irradiator controls for quality and regulatory compliance

    NASA Astrophysics Data System (ADS)

    Harding, Rorry B.; Pinteric, Francis J. A.

    1995-09-01

    Since 1978 the U.S. Food and Drug Administration (FDA) has had both the legal authority and the Current Good Manufacturing Practice (CGMP) regulations in place to require irradiator owners who process medical devices to produce evidence of Irradiation Process Validation. One of the key components of Irradiation Process Validation is the validation of the irradiator controls. However, it is only recently that FDA audits have focused on this component of the process validation. What is Irradiator Control System Validation? What constitutes evidence of control? How do owners obtain evidence? What is the irradiator supplier's role in validation? How does the ISO 9000 Quality Standard relate to the FDA's CGMP requirement for evidence of Control System Validation? This paper presents answers to these questions based on the recent experiences of Nordion's engineering and product management staff who have worked with several US-based irradiator owners. This topic — Validation of Irradiator Controls — is a significant regulatory compliance and operations issue within the irradiator suppliers' and users' community.

  3. Quality by control: Towards model predictive control of mammalian cell culture bioprocesses.

    PubMed

    Sommeregger, Wolfgang; Sissolak, Bernhard; Kandra, Kulwant; von Stosch, Moritz; Mayer, Martin; Striedner, Gerald

    2017-07-01

    The industrial production of complex biopharmaceuticals using recombinant mammalian cell lines is still mainly built on a quality by testing approach, which is represented by fixed process conditions and extensive testing of the end-product. In 2004 the FDA launched the process analytical technology initiative, aiming to guide the industry towards advanced process monitoring and better understanding of how critical process parameters affect the critical quality attributes. Implementation of process analytical technology into the bio-production process enables moving from the quality by testing to a more flexible quality by design approach. The application of advanced sensor systems in combination with mathematical modelling techniques offers enhanced process understanding, allows on-line prediction of critical quality attributes and subsequently real-time product quality control. In this review opportunities and unsolved issues on the road to a successful quality by design and dynamic control implementation are discussed. A major focus is directed on the preconditions for the application of model predictive control for mammalian cell culture bioprocesses. Design of experiments providing information about the process dynamics upon parameter change, dynamic process models, on-line process state predictions and powerful software environments seem to be a prerequisite for quality by control realization. © 2017 The Authors. Biotechnology Journal published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. Towards a New Science: Control and Accountability in Collaborations between Workers and Scientists.

    ERIC Educational Resources Information Center

    Merrifield, Juliet; Lippin, Tobi

    1989-01-01

    An occupational health survey conducted by union members in collaboration with an epidemiologist found that stress is a major occupational hazard. Conflict over dissemination of the results raised issues about who controls the research process and its outcomes, to whom are researchers accountable, and whether the scientific method can be used to…

  5. Real-time monitoring, prognosis, and resilient control for wind turbine systems

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gao, Zhiwei; Sheng, Shuangwen

    This special issue aims to provide a platform for academic and industrial communities to report recent results and emerging research in real-time monitoring, fault diagnosis, prognosis, and resilient control and design of wind turbine systems. After a strict peer-review process, 20 papers were selected, which represent the most recent progress of the real-time monitoring, diagnosis, prognosis, and resilient control methods/techniques in wind turbine systems.

  6. Reusable Solid Rocket Motor - Accomplishment, Lessons, and a Culture of Success

    NASA Technical Reports Server (NTRS)

    Moore, D. R.; Phelps, W. J.

    2011-01-01

    The Reusable Solid Rocket Motor (RSRM) represents the largest solid rocket motor (SRM) ever flown and the only human-rated solid motor. High reliability of the RSRM has been the result of challenges addressed and lessons learned. Advancements have resulted by applying attention to process control, testing, and postflight through timely and thorough communication in dealing with all issues. A structured and disciplined approach was taken to identify and disposition all concerns. Careful consideration and application of alternate opinions was embraced. Focus was placed on process control, ground test programs, and postflight assessment. Process control is mandatory for an SRM, because an acceptance test of the delivered product is not feasible. The RSRM maintained both full-scale and subscale test articles, which enabled continuous improvement of design and evaluation of process control and material behavior. Additionally RSRM reliability was achieved through attention to detail in post flight assessment to observe any shift in performance. The postflight analysis and inspections provided invaluable reliability data as it enables observation of actual flight performance, most of which would not be available if the motors were not recovered. RSRM reusability offered unique opportunities to learn about the hardware. NASA is moving forward with the Space Launch System that incorporates propulsion systems that takes advantage of the heritage Shuttle and Ares solid motor programs. These unique challenges, features of the RSRM, materials and manufacturing issues, and design improvements will be discussed in the paper.

  7. PEP Run Report for Integrated Test A, Caustic Leaching in UFP-VSL-T01A, Oxidative Leaching in UFP-VSL-T02A

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Guzman-Leong, Consuelo E.; Bredt, Ofelia P.; Burns, Carolyn A.

    2009-12-04

    Pacific Northwest National Laboratory (PNNL) was tasked by Bechtel National Inc. (BNI) on the River Protection Project-Hanford Tank Waste Treatment and Immobilization Plant (RPP-WTP) project to perform research and development activities to resolve technical issues identified for the Pretreatment Facility (PTF). The Pretreatment Engineering Platform (PEP) was designed and constructed and operated as part of a plan to respond to issue M12, “Undemonstrated Leaching Processes.”(a) The PEP, located in the Process Engineering Laboratory-West (PDLW) located in Richland, Washington, is a 1/4.5-scale test platform designed to simulate the WTP pretreatment caustic leaching, oxidative leaching, ultrafiltration solids concentration, and slurry washing processes.more » The PEP replicates the WTP leaching processes using prototypic equipment and control strategies. The PEP also includes non-prototypic ancillary equipment to support the core processing.« less

  8. National Historic Preservation Act (NHPA) Section 106 Process: Florence Copper, Inc. (FCI)

    EPA Pesticide Factsheets

    Collection of National Historic Preservation Act (NHPA) documents relating to Public Notice of Intent to Issue a Class III Underground Injection Control Area Permit for Florence Copper, Inc. (FCI) - Florence, AZ (closed)

  9. Neural Correlates of Emotion Regulation in the Ventral Prefrontal Cortex and the Encoding of Subjective Value and Economic Utility

    PubMed Central

    Viviani, Roberto

    2014-01-01

    In many studies of the interaction between cognitive control and emotion, the orbitofrontal cortex/ventromedial prefrontal cortex (mOFC/vmPFC) has been associated with an inhibitory function on limbic areas activated by emotionally arousing stimuli, such as the amygdala. This has led to the hypothesis of an inhibitory or regulatory role of mOFC/vmPFC. In studies of cognition and executive function, however, this area is deactivated by focused effort, raising the issue of the nature of the putative regulatory process associated with mOFC/vmPFC. This issue is here revisited in light of findings in the neuroeconomics field demonstrating the importance of mOFC/vmPFC to encoding the subjective value of stimuli or their economic utility. Many studies show that mOFC/vmPFC activity may affect response by activating personal preferences, instead of resorting to effortful control mechanisms typically associated with emotion regulation. Based on these findings, I argue that a simple automatic/controlled dichotomy is insufficient to describe the data on emotion and control of response adequately. Instead, I argue that the notion of subjective value from neuroeconomics studies and the notion of attentional orienting may play key roles in integrating emotion and cognition. mOFC/vmPFC may work together with the inferior parietal lobe, the cortical region associated with attentional orienting, to convey information about motivational priorities and facilitate processing of inputs that are behaviorally relevant. I also suggest that the dominant mode of function of this ventral network may be a distinct type of process with intermediate properties between the automatic and the controlled, and which may co-operate with effortful control processes in order to steer response. PMID:25309459

  10. [Related issues in clinical translational application of adipose-derived stem cells].

    PubMed

    Liu, Hongwei; Cheng, Biao; Fu, Xiaobing

    2012-10-01

    To introduce the related issues in the clinical translational application of adipose-derived stem cells (ASCs). The latest papers were extensively reviewed, concerning the issues of ASCs production, management, transportation, use, and safety during clinical application. ASCs, as a new member of adult stem cells family, bring to wide application prospect in the field of regenerative medicine. Over 40 clinical trials using ASCs conducted in 15 countries have been registered on the website (http://www.clinicaltrials.gov) of the National Institutes of Health (NIH), suggesting that ASCs represents a promising approach to future cell-based therapies. In the clinical translational application, the related issues included the quality control standard that management and production should follow, the prevention measures of pathogenic microorganism pollution, the requirements of enzymes and related reagent in separation process, possible effect of donor site, age, and sex in sampling, low temperature storage, product transportation, and safety. ASCs have the advantage of clinical translational application, much attention should be paid to these issues in clinical application to accelerate the clinical translation process.

  11. The influence of viewing an entertainment-education program on cornea donation intention: a test of the theory of planned behavior.

    PubMed

    Bae, Hyuhn-Suhck; Kang, Seok

    2008-01-01

    This study was designed to examine the role of issue involvement and the 3 components of the theory of planned behavior in predicting intentions to sign a cornea donor card. This study also compares viewers and nonviewers of an entertainment-education program in terms of issue involvement and the theory of planned behavior. The breakdown of effects for the latent constructs confirms that issue involvement is an important intermediary in the persuasion process. Issue involvement is a common causal antecedent of attitude, subjective norm, and perceived behavioral control, the last 2 of which, in turn, predict intentions, whereas attitude does not. The revised path model confirms that involvement directly influences intentions. In the comparison of viewers with nonviewers, viewers exhibit a significantly higher degree of involvement, attitude toward cornea donation, subjective norm, perceived behavioral control, and intention to sign a cornea donor card. The overall findings of this study suggest that adding issue involvement in the theory of planned behavior enhances the explanatory power of the theory in predicting intentions.

  12. Distributed digital signal processors for multi-body flexible structures

    NASA Technical Reports Server (NTRS)

    Lee, Gordon K. F.

    1992-01-01

    Multi-body flexible structures, such as those currently under investigation in spacecraft design, are large scale (high-order) dimensional systems. Controlling and filtering such structures is a computationally complex problem. This is particularly important when many sensors and actuators are located along the structure and need to be processed in real time. This report summarizes research activity focused on solving the signal processing (that is, information processing) issues of multi-body structures. A distributed architecture is developed in which single loop processors are employed for local filtering and control. By implementing such a philosophy with an embedded controller configuration, a supervising controller may be used to process global data and make global decisions as the local devices are processing local information. A hardware testbed, a position controller system for a servo motor, is employed to illustrate the capabilities of the embedded controller structure. Several filtering and control structures which can be modeled as rational functions can be implemented on the system developed in this research effort. Thus the results of the study provide a support tool for many Control/Structure Interaction (CSI) NASA testbeds such as the Evolutionary model and the nine-bay truss structure.

  13. Magellan aerobraking periapse corridor design

    NASA Technical Reports Server (NTRS)

    Cook, Richard A.; Lyons, Daniel T.

    1992-01-01

    One extended mission idea for the Magellan project uses aerobraking techniques to circularize the current orbit. A major technical issue in this proposal is the design of the periapse altitude corridor. Aerobraking would cause a number of significant side effects on both the spacecraft and ground system. Heating and aerodynamic torques on the spacecraft are key issues, as are the corridor control maneuver frequency and aerobrake duration. Spacecraft and ground systems operational limits have been identified in an attempt to constrain the corridor design. A simulation program has been developed to model the aerobraking corridor control process. This paper presents study results using this program which relate to the feasibility of this aerobraking concept.

  14. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    This report contains papers on the following topics: NREN Security Issues: Policies and Technologies; Layer Wars: Protect the Internet with Network Layer Security; Electronic Commission Management; Workflow 2000 - Electronic Document Authorization in Practice; Security Issues of a UNIX PEM Implementation; Implementing Privacy Enhanced Mail on VMS; Distributed Public Key Certificate Management; Protecting the Integrity of Privacy-enhanced Electronic Mail; Practical Authorization in Large Heterogeneous Distributed Systems; Security Issues in the Truffles File System; Issues surrounding the use of Cryptographic Algorithms and Smart Card Applications; Smart Card Augmentation of Kerberos; and An Overview of the Advanced Smart Card Access Control System.more » Selected papers were processed separately for inclusion in the Energy Science and Technology Database.« less

  15. Thick resist for MEMS processing

    NASA Astrophysics Data System (ADS)

    Brown, Joe; Hamel, Clifford

    2001-11-01

    The need for technical innovation is always present in today's economy. Microfabrication methods have evolved in support of the demand for smaller and faster integrated circuits with price performance improvements always in the scope of the manufacturing design engineer. The dispersion of processing technology spans well beyond IC fabrication today with batch fabrication and wafer scale processing lending advantages to MEMES applications from biotechnology to consumer electronics from oil exploration to aerospace. Today the demand for innovative processing techniques that enable technology is apparent where only a few years ago appeared too costly or not reliable. In high volume applications where yield and cost improvements are measured in fractions of a percent it is imperative to have process technologies that produce consistent results. Only a few years ago thick resist coatings were limited to thickness less than 20 microns. Factors such as uniformity, edge bead and multiple coatings made high volume production impossible. New developments in photoresist formulation combined with advanced coating equipment techniques that closely controls process parameters have enable thick photoresist coatings of 70 microns with acceptable uniformity and edge bead in one pass. Packaging of microelectronic and micromechanical devices is often a significant cost factor and a reliability issue for high volume low cost production. Technologies such as flip- chip assembly provide a solution for cost and reliability improvements over wire bond techniques. The processing for such technology demands dimensional control and presents a significant cost savings if it were compatible with mainstream technologies. Thick photoresist layers, with good sidewall control would allow wafer-bumping technologies to penetrate the barriers to yield and production where costs for technology are the overriding issue. Single pass processing is paramount to the manufacturability of packaging technology. Uniformity and edge bead control defined the success of process implementation. Today advanced packaging solutions are created with thick photoresist coatings. The techniques and results will be presented.

  16. Cost Analysis In A Multi-Mission Operations Environment

    NASA Technical Reports Server (NTRS)

    Newhouse, M.; Felton, L.; Bornas, N.; Botts, D.; Roth, K.; Ijames, G.; Montgomery, P.

    2014-01-01

    Spacecraft control centers have evolved from dedicated, single-mission or single missiontype support to multi-mission, service-oriented support for operating a variety of mission types. At the same time, available money for projects is shrinking and competition for new missions is increasing. These factors drive the need for an accurate and flexible model to support estimating service costs for new or extended missions; the cost model in turn drives the need for an accurate and efficient approach to service cost analysis. The National Aeronautics and Space Administration (NASA) Huntsville Operations Support Center (HOSC) at Marshall Space Flight Center (MSFC) provides operations services to a variety of customers around the world. HOSC customers range from launch vehicle test flights; to International Space Station (ISS) payloads; to small, short duration missions; and has included long duration flagship missions. The HOSC recently completed a detailed analysis of service costs as part of the development of a complete service cost model. The cost analysis process required the team to address a number of issues. One of the primary issues involves the difficulty of reverse engineering individual mission costs in a highly efficient multimission environment, along with a related issue of the value of detailed metrics or data to the cost model versus the cost of obtaining accurate data. Another concern is the difficulty of balancing costs between missions of different types and size and extrapolating costs to different mission types. The cost analysis also had to address issues relating to providing shared, cloud-like services in a government environment, and then assigning an uncertainty or risk factor to cost estimates that are based on current technology, but will be executed using future technology. Finally the cost analysis needed to consider how to validate the resulting cost models taking into account the non-homogeneous nature of the available cost data and the decreasing flight rate. This paper presents the issues encountered during the HOSC cost analysis process, and the associated lessons learned. These lessons can be used when planning for a new multi-mission operations center or in the transformation from a dedicated control center to multi-center operations, as an aid in defining processes that support future cost analysis and estimation. The lessons can also be used by mature serviceoriented, multi-mission control centers to streamline or refine their cost analysis process.

  17. Cost Analysis in a Multi-Mission Operations Environment

    NASA Technical Reports Server (NTRS)

    Felton, Larry; Newhouse, Marilyn; Bornas, Nick; Botts, Dennis; Ijames, Gayleen; Montgomery, Patty; Roth, Karl

    2014-01-01

    Spacecraft control centers have evolved from dedicated, single-mission or single mission-type support to multi-mission, service-oriented support for operating a variety of mission types. At the same time, available money for projects is shrinking and competition for new missions is increasing. These factors drive the need for an accurate and flexible model to support estimating service costs for new or extended missions; the cost model in turn drives the need for an accurate and efficient approach to service cost analysis. The National Aeronautics and Space Administration (NASA) Huntsville Operations Support Center (HOSC) at Marshall Space Flight Center (MSFC) provides operations services to a variety of customers around the world. HOSC customers range from launch vehicle test flights; to International Space Station (ISS) payloads; to small, short duration missions; and has included long duration flagship missions. The HOSC recently completed a detailed analysis of service costs as part of the development of a complete service cost model. The cost analysis process required the team to address a number of issues. One of the primary issues involves the difficulty of reverse engineering individual mission costs in a highly efficient multi-mission environment, along with a related issue of the value of detailed metrics or data to the cost model versus the cost of obtaining accurate data. Another concern is the difficulty of balancing costs between missions of different types and size and extrapolating costs to different mission types. The cost analysis also had to address issues relating to providing shared, cloud-like services in a government environment, and then assigning an uncertainty or risk factor to cost estimates that are based on current technology, but will be executed using future technology. Finally the cost analysis needed to consider how to validate the resulting cost models taking into account the non-homogeneous nature of the available cost data and the decreasing flight rate. This paper presents the issues encountered during the HOSC cost analysis process, and the associated lessons learned. These lessons can be used when planning for a new multi-mission operations center or in the transformation from a dedicated control center to multi-center operations, as an aid in defining processes that support future cost analysis and estimation. The lessons can also be used by mature service-oriented, multi-mission control centers to streamline or refine their cost analysis process.

  18. Operationalizing Space Weather Products - Process and Issues

    NASA Astrophysics Data System (ADS)

    Scro, K. D.; Quigley, S.

    2006-12-01

    Developing and transitioning operational products for any customer base is a complicated process. This is the case for operational space weather products and services for the USAF. This presentation will provide information on the current state of affairs regarding the process required to take an idea from the research field to the real-time application of 24-hour space weather operations support. General principles and specific issues are discussed and will include: customer requirements, organizations in-play, funding, product types, acquisition of engineering and validation data, security classification, version control, and various important changes that occur during the process. The author's viewpoint is as an individual developing space environmental system-impact products for the US Air Force: 1) as a member of its primary research organization (Air Force Research Laboratory), 2) working with its primary space environment technology transition organization (Technology Application Division of the Space and Missile Systems Center, SMC/WXT), and 3) delivering to the primary sponsor/customer of such system-impact products (Air Force Space Command). The experience and focus is obviously on specific military operationalization process and issues, but most of the paradigm may apply to other (commercial) enterprises as well.

  19. Replacing Gasoline : Alternative Fuels for Light-Duty Vehicles

    DOT National Transportation Integrated Search

    1990-09-01

    Among the several major issues that Congress addressed in the process of reauthorizing the Clean Air Act was the future role of alternative highway transportation fuels in reducing urban smog. As vehicular emissions control efficiencies rose past 90 ...

  20. Clients as Teachers.

    ERIC Educational Resources Information Center

    Journal of Counseling and Development, 1988

    1988-01-01

    Contains eight accounts: "But Kids Don't Commit Suicide" (Sharon Andreozzi); "Learning from Multiplicity" (Kathryn Ellis); "Autonomy, Control, and Affiliation: Your Issues or Mine?" (Claudia Haferkamp); "Role Players" (Dennis Heitzmann); "Grief Counseling: Facilitating the Healing Process" (Rosemary Hughes); "Hospital Referral: A Test of Counselor…

  1. Hybrid intelligent control of substrate feeding for industrial fed-batch chlortetracycline fermentation process.

    PubMed

    Jin, Huaiping; Chen, Xiangguang; Yang, Jianwen; Wu, Lei; Wang, Li

    2014-11-01

    The lack of accurate process models and reliable online sensors for substrate measurements poses significant challenges for controlling substrate feeding accurately, automatically and optimally in fed-batch fermentation industries. It is still a common practice to regulate the feeding rate based upon manual operations. To address this issue, a hybrid intelligent control method is proposed to enable automatic substrate feeding. The resulting control system consists of three modules: a presetting module for providing initial set-points; a predictive module for estimating substrate concentration online based on a new time interval-varying soft sensing algorithm; and a feedback compensator using expert rules. The effectiveness of the proposed approach is demonstrated through its successful applications to the industrial fed-batch chlortetracycline fermentation process. Copyright © 2014 ISA. Published by Elsevier Ltd. All rights reserved.

  2. Qualification Procedures for VHSIC/VLSI

    DTIC Science & Technology

    1990-12-01

    alternative approach for qualification of complex microcircuits. To address the technical issues related to a process oriented qualification approach, the...methodology of microcircuit process control to promote the United States to a position of supplying the nighest quality and most reliable...available resources . o Coordinate document reviews with weekly and monthly status reviews on progress. o Summarize results and collate into four basic

  3. Improve T Cell Therapy in Neuroblastoma

    DTIC Science & Technology

    2013-07-01

    ear, and spleen of treated mice. Control mice showed evidence of chronic dermatitis , with moderate diffuse epithelial hyperplasia, hyperkeratosis and...treated mice. Control mice showed evidence of chronic dermatitis , with moderate diffuse epithelial hyperplasia, hyperkeratosis and marked multi- focal...in question to contact us about making the changes. Please note, however, that the manuscript would be held from further processing until this issue

  4. Attacking invasive grasses

    USGS Publications Warehouse

    Keeley, Jon E.

    2015-01-01

    In grasslands fire may play a role in the plant invasion process, both by creating disturbances that potentially favour non-native invasions and as a possible tool for controlling alien invasions. Havill et al. (Applied Vegetation Science, 18, 2015, this issue) determine how native and non-native species respond to different fire regimes as a first step in understanding the potential control of invasive grasses.

  5. Some Ecological Contexts of Attitudes Concerning Issues of Civil Defense.

    DTIC Science & Technology

    1983-03-01

    Urban Research AEAWOKUINMER University of Pittsburgh 48121 Pittsburgh, PA 15260 It. CONTROLLING OFFICE NAME AND ADDRESS IS. REPORT OATS March, 1983...Federal Emergency Management Agency 13. NUJMBER OF PAGES Washington, D.C. 2047227 14. MONITORING AGENCY NAME & AODRIESS(lf different 1mm Controlling ...period and prior to any Presidential action) is also quite credible (since in such a process, the individual families " control ," so to say, the time of

  6. Interoperability for Space Mission Monitor and Control: Applying Technologies from Manufacturing Automation and Process Control Industries

    NASA Technical Reports Server (NTRS)

    Jones, Michael K.

    1998-01-01

    Various issues associated with interoperability for space mission monitor and control are presented in viewgraph form. Specific topics include: 1) Space Project Mission Operations Control Architecture (SuperMOCA) goals and methods for achieving them; 2) Specifics on the architecture: open standards ad layering, enhancing interoperability, and promoting commercialization; 3) An advertisement; 4) Status of the task - government/industry cooperation and architecture and technology demonstrations; and 5) Key features of messaging services and virtual devices.

  7. Planetary protection, legal ambiguity and the decision making process for Mars sample return

    NASA Technical Reports Server (NTRS)

    Race, M. S.

    1996-01-01

    As scientists and mission planners develop planetary protection requirements for future Mars sample return missions, they must recognize the socio-political context in which decisions about the mission will be made and pay careful attention to public concerns about potential back contamination of Earth. To the extent that planetary protection questions are unresolved or unaddressed at the time of an actual mission, they offer convenient footholds for public challenges in both legal and decision making realms, over which NASA will have little direct control. In this paper, two particular non-scientific areas of special concern are discussed in detail: 1) legal issues and 2) the decision making process. Understanding these areas is critical for addressing legitimate public concerns as well as for fulfilling procedural requirements regardless whether sample return evokes public controversy. Legal issues with the potential to complicate future missions include: procedural review under National Environmental Policy Act (NEPA); uncertainty about institutional control and authority; conflicting regulations and overlapping jurisdictions; questions about international treaty obligations and large scale impacts; uncertanities about the nature of the organism; and constitutional and regulatory concerns about quarantine, public health and safety. In light of these important legal issues, it is critical that NASA consider the role and timing of public involvement in the decision making process as a way of anticipating problem areas and preparing for legitimate public questions and challenges to sample return missions.

  8. Controlling the leakage of liquid bismuth cathode elements in ceramic crucibles used for the electrowinning process in pyroprocessing

    NASA Astrophysics Data System (ADS)

    Kim, Dae-Young; Hwang, Il-Soon; Lee, Jong-Hyeon

    2016-09-01

    Pyroprocessing has shown promise as an alternative to wet processing for the recycling of transuranics with a high proliferation resistance. However, a critical issue for pyroprocessing is the ceramic crucibles used in the electrowinning process. These ceramic crucibles are frequently damaged by thermal stress, which results in significant volumes of crucible waste that must be properly disposed. Transuranic waste (TRU) elements intrude throughout the pores of a damaged crucible. The volume of generated radioactive waste is a concern when dealing with nuclear power plants and decontamination issues. In this study, laser treatment and sintering were performed on the crucibles to minimize the TRU elements trapped within. Secondary ion mass spectroscopy was used to measure the intrusion depth of Li in the surface-treated ceramics.

  9. A management-control system to assist with the development, contracting, and monitoring of new services for older people: you can always get what you want (with apologies to the Rolling Stones).

    PubMed

    Jacobs, Stephen

    2007-10-01

    Implementing community services can be a very complex process where people end up "not seeing the wood for the trees" and then accepting a compromise nobody wants. Neither agency theory nor stewardship theory is particularly robust when explaining the reality that funders and managers of community health service for older people face in managing contracts. There are particular difficulties with goal divergence between policy directives and implementation practices, which result from goals not being well understood and performance requirements being ambiguously defined and infrequently monitored. This leads to accountability issues for public managers, and raises efficiency and effectiveness issues. This paper provides an interim report on a project developing a management-control system to provide a process for health planners and funders to use when developing and contracting services. A major focus is inviting stakeholders into a process of communication that ensures that they have shared understandings of where they want to get to, and what has to be done to get there.

  10. Controlled versus automatic processes: which is dominant to safety? The moderating effect of inhibitory control.

    PubMed

    Xu, Yaoshan; Li, Yongjuan; Ding, Weidong; Lu, Fan

    2014-01-01

    This study explores the precursors of employees' safety behaviors based on a dual-process model, which suggests that human behaviors are determined by both controlled and automatic cognitive processes. Employees' responses to a self-reported survey on safety attitudes capture their controlled cognitive process, while the automatic association concerning safety measured by an Implicit Association Test (IAT) reflects employees' automatic cognitive processes about safety. In addition, this study investigates the moderating effects of inhibition on the relationship between self-reported safety attitude and safety behavior, and that between automatic associations towards safety and safety behavior. The results suggest significant main effects of self-reported safety attitude and automatic association on safety behaviors. Further, the interaction between self-reported safety attitude and inhibition and that between automatic association and inhibition each predict unique variances in safety behavior. Specifically, the safety behaviors of employees with lower level of inhibitory control are influenced more by automatic association, whereas those of employees with higher level of inhibitory control are guided more by self-reported safety attitudes. These results suggest that safety behavior is the joint outcome of both controlled and automatic cognitive processes, and the relative importance of these cognitive processes depends on employees' individual differences in inhibitory control. The implications of these findings for theoretical and practical issues are discussed at the end.

  11. Controlled versus Automatic Processes: Which Is Dominant to Safety? The Moderating Effect of Inhibitory Control

    PubMed Central

    Xu, Yaoshan; Li, Yongjuan; Ding, Weidong; Lu, Fan

    2014-01-01

    This study explores the precursors of employees' safety behaviors based on a dual-process model, which suggests that human behaviors are determined by both controlled and automatic cognitive processes. Employees' responses to a self-reported survey on safety attitudes capture their controlled cognitive process, while the automatic association concerning safety measured by an Implicit Association Test (IAT) reflects employees' automatic cognitive processes about safety. In addition, this study investigates the moderating effects of inhibition on the relationship between self-reported safety attitude and safety behavior, and that between automatic associations towards safety and safety behavior. The results suggest significant main effects of self-reported safety attitude and automatic association on safety behaviors. Further, the interaction between self-reported safety attitude and inhibition and that between automatic association and inhibition each predict unique variances in safety behavior. Specifically, the safety behaviors of employees with lower level of inhibitory control are influenced more by automatic association, whereas those of employees with higher level of inhibitory control are guided more by self-reported safety attitudes. These results suggest that safety behavior is the joint outcome of both controlled and automatic cognitive processes, and the relative importance of these cognitive processes depends on employees' individual differences in inhibitory control. The implications of these findings for theoretical and practical issues are discussed at the end. PMID:24520338

  12. 3D image processing architecture for camera phones

    NASA Astrophysics Data System (ADS)

    Atanassov, Kalin; Ramachandra, Vikas; Goma, Sergio R.; Aleksic, Milivoje

    2011-03-01

    Putting high quality and easy-to-use 3D technology into the hands of regular consumers has become a recent challenge as interest in 3D technology has grown. Making 3D technology appealing to the average user requires that it be made fully automatic and foolproof. Designing a fully automatic 3D capture and display system requires: 1) identifying critical 3D technology issues like camera positioning, disparity control rationale, and screen geometry dependency, 2) designing methodology to automatically control them. Implementing 3D capture functionality on phone cameras necessitates designing algorithms to fit within the processing capabilities of the device. Various constraints like sensor position tolerances, sensor 3A tolerances, post-processing, 3D video resolution and frame rate should be carefully considered for their influence on 3D experience. Issues with migrating functions such as zoom and pan from the 2D usage model (both during capture and display) to 3D needs to be resolved to insure the highest level of user experience. It is also very important that the 3D usage scenario (including interactions between the user and the capture/display device) is carefully considered. Finally, both the processing power of the device and the practicality of the scheme needs to be taken into account while designing the calibration and processing methodology.

  13. Producing thin strips by twin-roll casting—part I: Process aspects and quality issues

    NASA Astrophysics Data System (ADS)

    Li, Ben Q.

    1995-05-01

    This two-part paper discusses recent advances in research and development for the direct production of coilable thin strips by twin-roll casting in both the aluminum and steel industries. While the former is empowering the casters to approach the theoretical productivity limit, the latter is striving to put pilot casters into commercial operation. These intensive R&D efforts are derived from the advantages, both economic and metallurgical, offered by the process. As twin-roll casting combines solidification and hot rolling into a single operation, the process requires low capital investment and low operational cost. Also, because of the high solidification rate attained in the process, the thin strips produced have a refined metallurgical structure, characterized by columnar and equiaxed zones with fine intermetallic particles. The enthusiasm about twin-roll casting is now being spread worldwide. This paper focuses on the process aspects and quality control of twin-roll casting. Part II, which will appear in the August issue, will review process modeling and pilot-plant development activities.

  14. TREATMENT OF MUNICIPAL SLUDGE FOR PATHOGEN REDUCTION

    EPA Science Inventory

    This presentation reviews the pathogenic microorganisms that may be found in municipal sewage sludge and the commonly employed Class A and B processes for controlling pathogens. It notes how extensively they are used and discusses issues and concerns with their application. The...

  15. PATHOGENS: VIEWS OF EPA'S PATHOGEN EQUIVALENCY COMMITTEE

    EPA Science Inventory

    This presentation reviews the pathogenic microorganisms that may be found in municipal sewage sludge and the commonly employed Class A and B processes for controlling pathogens. It notes how extensively they are used and discusses issues and concerns with their application. Pre...

  16. 2011 Quantum Control of Light & Matter Gordon Research Conference (July 31-August 5, 2011, Mount Holyoke College, South Hadley, MA)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Thomas Weinacht

    2011-08-05

    Quantum control of light and matter is the quest to steer a physical process to a desirable outcome, employing constructive and destructive interference. Three basic questions address feasibility of quantum control: (1) The problem of controllability, does a control field exist for a preset initial and target state; (2) Synthesis, constructively finding the field that leads to the target; and (3) Optimal Control Theory - optimizing the field that carries out this task. These continue to be the fundamental theoretical questions to be addressed in the conference. How to realize control fields in the laboratory is an ongoing challenge. Thismore » task is very diverse viewing the emergence of control scenarios ranging from attoseconds to microseconds. How do the experimental observations reflect on the theoretical framework? The typical arena of quantum control is an open environment where much of the control is indirect. How are control scenarios realized in dissipative open systems? Can new control opportunities emerge? Can one null decoherence effects? An ideal setting for control is ultracold matter. The initial and final state can be defined more precisely. Coherent control unifies many fields of physical science. A lesson learned in one field can reflect on another. Currently quantum information processing has emerged as a primary target of control where the key issue is controlling quantum gate operation. Modern nonlinear spectroscopy has emerged as another primary field. The challenge is to unravel the dynamics of molecular systems undergoing strong interactions with the environment. Quantum optics where non-classical fields are to be generated and employed. Finally, coherent control is the basis for quantum engineering. These issues will be under the limelight of the Gordon conference on Quantum Control of Light and Matter.« less

  17. Implementation of object-oriented programming in study of electrical race car

    NASA Astrophysics Data System (ADS)

    Nowak, M.; Baier, M.

    2016-08-01

    The paper covers issue of conducting advanced research of electrical race car participating in international competition called Sileverline Corporate Challenge. Process of designing race cars in Silesian Greenpower team is aided by a professional engine test stand built particularly in purpose of this research. Phase of testing and simulation is an important part of the implementation of new technologies. Properly developed solutions and test procedures are able to significantly shorten development time and reduce design costs. Testing process must be controlled by a modular and flexible application, easy to modify and ensuring safety. This paper describes the concept of object-oriented programming in LabVIEW and exemplary architecture of object-oriented control application designed to control engine test stand of the electrical race car. Eventually, the task of application will be to steer the electromagnetic brake and the engine load torque to perform according to data from the actual race track. During the designing process of the car, minimizing energy losses and maximizing powertrain efficiency are the main aspects taken into consideration. One of the crucial issues to accomplish these goals is to maintain optimal performance of the motor by applying effective cooling. The paper covers the research verifying the effectiveness of the cooling system.

  18. Transplantable tissue growth-a commercial space venture

    NASA Astrophysics Data System (ADS)

    Giuntini, Ronald E.; Vardaman, William K.

    1997-01-01

    Rantek was incorporated in 1984 to pursue research toward product development in space based biotechnology. The company has maintained an aggressive experiment flight program since 1989 having flown biotechnology experiments in six Consort rockets flights, one Joust rocket flight and eight Space Shuttle missions. The objective of these flights was to conduct a series of research experiments to resolve issues affecting transplantable tissue growth feasibility. The purpose of the flight research was to determine the behavior of lymphocyte mixing, activation, magnetic mixing and process control, drug studies in a model leukemia cell line, and various aspects of the hardware system process control in the low gravity of space. The company is now preparing for a two Space Shuttle flight program as precursors to a sustained, permanent, commercial venture at the Space Station. The shuttle flights will enable new, larger scale tissue growth systems to be tested to determine fundamental process control sensitivity and growth rates unique to a number of tissue types. The answer to these issues will ultimately determine the commercial viability of the Rantek Biospace program. This paper addresses considerations that will drive the cost of a space venture-the largest cost driver will be the cost to and from the station and the cost at the station.

  19. Root Cause Analysis of Quality Defects Using HPLC-MS Fingerprint Knowledgebase for Batch-to-batch Quality Control of Herbal Drugs.

    PubMed

    Yan, Binjun; Fang, Zhonghua; Shen, Lijuan; Qu, Haibin

    2015-01-01

    The batch-to-batch quality consistency of herbal drugs has always been an important issue. To propose a methodology for batch-to-batch quality control based on HPLC-MS fingerprints and process knowledgebase. The extraction process of Compound E-jiao Oral Liquid was taken as a case study. After establishing the HPLC-MS fingerprint analysis method, the fingerprints of the extract solutions produced under normal and abnormal operation conditions were obtained. Multivariate statistical models were built for fault detection and a discriminant analysis model was built using the probabilistic discriminant partial-least-squares method for fault diagnosis. Based on multivariate statistical analysis, process knowledge was acquired and the cause-effect relationship between process deviations and quality defects was revealed. The quality defects were detected successfully by multivariate statistical control charts and the type of process deviations were diagnosed correctly by discriminant analysis. This work has demonstrated the benefits of combining HPLC-MS fingerprints, process knowledge and multivariate analysis for the quality control of herbal drugs. Copyright © 2015 John Wiley & Sons, Ltd.

  20. Policy statement--pediatric organ donation and transplantation.

    PubMed

    2010-04-01

    Pediatric organ donation and organ transplantation can have a significant life-extending benefit to the young recipients of these organs and a high emotional impact on donor and recipient families. Pediatricians, pediatric medical specialists, and pediatric transplant surgeons need to be better acquainted with evolving national strategies that involve organ procurement and organ transplantation to help acquaint families with the benefits and risks of organ donation and transplantation. Efforts of pediatric professionals are needed to shape public policies to provide a system in which procurement, distribution, and cost are fair and equitable to children and adults. Major issues of concern are availability of and access to donor organs; oversight and control of the process; pediatric medical and surgical consultation and continued care throughout the organ-donation and transplantation process; ethical, social, financial, and follow-up issues; insurance-coverage issues; and public awareness of the need for organ donors of all ages.

  1. Addendum report to atmospheric science facility pallet-only mode space transportation system payload feasibility study, volume 3, revision A

    NASA Technical Reports Server (NTRS)

    1976-01-01

    The feasibility of accomplishing selected atmospheric science mission using a pallet-only mode was studied. Certain unresolved issues were identified. The first issue was that of assuring that the on-board computer facility was adequate to process scientific data, control subsystems such as instrument pointing, provide mission operational program capability, and accomplish display and control. The second issue evolved from an investigation of the availability of existing substitute instruments that could be used instead of the prime instrumentation where the development tests and schedules are incompatible with the realistic budgets and shuttle vehicle schedules. Some effort was expended on identifying candidate substitute instruments, and the performance, cost, and development schedule trade-offs found during that effort were significant enough to warrant a follow-on investigation. This addendum documents the results of that follow-on effort, as it applies to the Atmospheric Sciences Facility.

  2. Deployment Simulation of Ultra-Lightweight Inflatable Structures

    NASA Technical Reports Server (NTRS)

    Wang, John T.; Johnson, Arthur R.

    2002-01-01

    Dynamic deployment analyses of folded inflatable tubes are conducted to investigate modeling issues related to the deployment of solar sail booms. The analyses are necessary because ground tests include gravity effects and may poorly represent deployment in space. A control volume approach, available in the LS-DYNA nonlinear dynamic finite element code, and the ideal gas law are used to simulate the dynamic inflation deployment process. Three deployment issues are investigated for a tube packaged in a Z-fold configuration. The issues are the effect of the rate of inflation, the effect of residual air, and the effect of gravity. The results of the deployment analyses reveal that the time and amount of inflation gas required to achieve a full deployment are related to these issues.

  3. Totally Integrated Munitions Enterprise ''Affordable Munitions Production for the 21st Century''

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Burleson, R.R.; Poggio, M.E.; Rosenberg, S.J.

    2000-09-13

    The U.S. Army faces several munitions manufacturing issues: downsizing of the organic production base, timely fielding of affordable smart munitions, and munitions replenishment during national emergencies. Totally Integrated Munitions Enterprise (TIME) is addressing these complex issues via the development and demonstration of an integrated enterprise. The enterprise will include the tools, network, and open modular architecture controllers to enable accelerated acquisition, shortened concept to volume production, lower life cycle costs, capture of critical manufacturing processes, and communication of process parameters between remote sites to rapidly spin-off production for replenishment by commercial sources. TIME addresses the enterprise as a system, integratingmore » design, engineering, manufacturing, administration, and logistics.« less

  4. Totally Integrated Munitions Enterprise ''Affordable Munitions Production for the 21st Century''

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Burleson, R.R.; Poggio, M.E.; Rosenberg, S.J.

    2000-07-14

    The U.S. Army faces several munitions manufacturing issues: downsizing of the organic production base, timely fielding of affordable smart munitions, and munitions replenishment during national emergencies. TIME is addressing these complex issues via the development and demonstration of an integrated enterprise. The enterprise will include the tools, network, and open modular architecture controller to enable accelerated acquisition, shortened concept to volume production, lower life cycle costs, capture of critical manufacturing processes, and communication of process parameters between remote sites to rapidly spin-off production for replenishment by commercial sources. TIME addresses the enterprise as a system, integrating design, engineering, manufacturing, administration,more » and logistics.« less

  5. Totally Integrated Munitions Enterprise ''Affordable Munitions Production for the 21st Century''

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Burleson, R.R.; Poggio, M.E.; Rosenberg, S.J.

    2000-08-18

    The U.S. Army faces several munitions manufacturing issues: downsizing of the organic production base, timely fielding of affordable smart munitions, and munitions replenishment during national emergencies. Totally Integrated Munitions Enterprise (TIME) is addressing these complex issues via the development and demonstration of an integrated enterprise. The enterprise will include the tools, network, and open modular architecture controllers to enable accelerated acquisition, shortened concept to volume production, lower life cycle costs, capture of critical manufacturing processes, and communication of process parameters between remote sites to rapidly spin-off production for replenishment by commercial sources. TIME addresses the enterprise as a system, integratingmore » design, engineering, manufacturing, administration, and logistics.« less

  6. Complexity and performance of on-chip biochemical assays

    NASA Astrophysics Data System (ADS)

    Kopf-Sill, Anne R.; Nikiforov, Theo; Bousse, Luc J.; Nagle, Rob; Parce, J. W.

    1997-03-01

    The use of microchips for performing biochemical processes has the potential to reduce reagent use and thus assay costs, increase throughput, and automate complex processes. We are building a multifunctional platform that provides sensing and actuation functions for a variety of microchip- based biochemical and analytical processes. Here we describe recent experiments that include on-chip dilution, reagent mixing, reaction, separation, and detection for important classes of biochemical assays. Issues in chip design and control are discussed.

  7. Energy Center Structure Optimization by using Smart Technologies in Process Control System

    NASA Astrophysics Data System (ADS)

    Shilkina, Svetlana V.

    2018-03-01

    The article deals with practical application of fuzzy logic methods in process control systems. A control object - agroindustrial greenhouse complex, which includes its own energy center - is considered. The paper analyzes object power supply options taking into account connection to external power grids and/or installation of own power generating equipment with various layouts. The main problem of a greenhouse facility basic process is extremely uneven power consumption, which forces to purchase redundant generating equipment idling most of the time, which quite negatively affects project profitability. Energy center structure optimization is largely based on solving the object process control system construction issue. To cut investor’s costs it was proposed to optimize power consumption by building an energy-saving production control system based on a fuzzy logic controller. The developed algorithm of automated process control system functioning ensured more even electric and thermal energy consumption, allowed to propose construction of the object energy center with a smaller number of units due to their more even utilization. As a result, it is shown how practical use of microclimate parameters fuzzy control system during object functioning leads to optimization of agroindustrial complex energy facility structure, which contributes to a significant reduction in object construction and operation costs.

  8. The effects of supervised learning on event-related potential correlates of music-syntactic processing.

    PubMed

    Guo, Shuang; Koelsch, Stefan

    2015-11-11

    Humans process music even without conscious effort according to implicit knowledge about syntactic regularities. Whether such automatic and implicit processing is modulated by veridical knowledge has remained unknown in previous neurophysiological studies. This study investigates this issue by testing whether the acquisition of veridical knowledge of a music-syntactic irregularity (acquired through supervised learning) modulates early, partly automatic, music-syntactic processes (as reflected in the early right anterior negativity, ERAN), and/or late controlled processes (as reflected in the late positive component, LPC). Excerpts of piano sonatas with syntactically regular and less regular chords were presented repeatedly (10 times) to non-musicians and amateur musicians. Participants were informed by a cue as to whether the following excerpt contained a regular or less regular chord. Results showed that the repeated exposure to several presentations of regular and less regular excerpts did not influence the ERAN elicited by less regular chords. By contrast, amplitudes of the LPC (as well as of the P3a evoked by less regular chords) decreased systematically across learning trials. These results reveal that late controlled, but not early (partly automatic), neural mechanisms of music-syntactic processing are modulated by repeated exposure to a musical piece. This article is part of a Special Issue entitled SI: Prediction and Attention. Copyright © 2015 Elsevier B.V. All rights reserved.

  9. Parental psychological control and dysfunctional separation-individuation: a tale of two different dynamics.

    PubMed

    Kins, Evie; Soenens, Bart; Beyers, Wim

    2012-10-01

    This study examined associations between psychologically controlling parenting and two possible manifestations of problematic separation-individuation (i.e., dysfunctional dependence and dysfunctional independence). To explain these associations, it has been argued that psychological control is an inherently independence-stifling parenting dimension that gives rise to a dysfunctional dependent orientation. In this study, it was argued that psychological control may relate to dysfunctional dependence and dysfunctional independence, depending on whether parents' use of psychological control is driven by issues of interpersonal closeness (i.e., dependency-oriented psychological control) or by issues of achievement (i.e., achievement-oriented psychological control). A Belgian sample of 232 emerging adults, involved in the process of home leaving, and their parents completed self-report questionnaires. Regression analyses indicated that domain-specific expressions of psychological control were related differentially to dysfunctional dependent and dysfunctional independent manifestations of problematic separation-individuation. Emerging adults' residential status did not moderate these associations. Implications and directions for future research are discussed. Copyright © 2012 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved.

  10. Satellite Power System (SPS)

    NASA Technical Reports Server (NTRS)

    Edler, H. G.

    1978-01-01

    Potential organizational options for a solar power satellite system (SPS) were investigated. Selection and evaluation criteria were determined to include timeliness, reliability, and adequacy to contribute meaningfully to the U.S. supply; political feasibility (both national and international); and cost effectiveness (including environmental and other external costs). Based on these criteria, four organizational alternatives appeared to offer reasonable promise as potential options for SPS. A large number of key issues emerged as being factors which would influence the final selection process. Among these issues were a variety having to do with international law, international institutions, environmental controls, economics, operational flexibility, congressional policies, commercial-vs-governmental ownership, national dedication, and national and operational stategic issues.

  11. MIMO model of an interacting series process for Robust MPC via System Identification.

    PubMed

    Wibowo, Tri Chandra S; Saad, Nordin

    2010-07-01

    This paper discusses the empirical modeling using system identification technique with a focus on an interacting series process. The study is carried out experimentally using a gaseous pilot plant as the process, in which the dynamic of such a plant exhibits the typical dynamic of an interacting series process. Three practical approaches are investigated and their performances are evaluated. The models developed are also examined in real-time implementation of a linear model predictive control. The selected model is able to reproduce the main dynamic characteristics of the plant in open-loop and produces zero steady-state errors in closed-loop control system. Several issues concerning the identification process and the construction of a MIMO state space model for a series interacting process are deliberated. 2010 ISA. Published by Elsevier Ltd. All rights reserved.

  12. Issues in Commercial Document Delivery.

    ERIC Educational Resources Information Center

    Marcinko, Randall Wayne

    1997-01-01

    Discusses (1) the history of document delivery; (2) the delivery process--end-user request, intermediary request, vendor reference, citation verification, obtaining document and source relations, quality control, transferring document to client, customer service and status, invoicing and billing, research and development, and copyright; and (3)…

  13. Quality transitivity and traceability system of herbal medicine products based on quality markers.

    PubMed

    Liu, Changxiao; Guo, De-An; Liu, Liang

    2018-05-15

    Due to a variety of factors to affect the herb quality, the existing quality management model is unable to evaluate the process control. The development of the concept of "quality marker" (Q-marker) lays basis for establishing an independent process quality control system for herbal products. To ensure the highest degree of safety, effectiveness and quality process control of herbal products, it is aimed to establish a quality transitivity and traceability system of quality and process control from raw materials to finished herbal products. Based on the key issues and challenges of quality assessment, the current status of quality and process controls from raw materials to herbal medicinal products listed in Pharmacopoeia were analyzed and the research models including discovery and identification of Q-markers, analysis and quality management of risk evaluation were designed. Authors introduced a few new technologies and methodologies, such as DNA barcoding, chromatographic technologies, fingerprint analysis, chemical markers, bio-responses, risk management and solution for quality process control. The quality and process control models for herbal medicinal products were proposed and the transitivity and traceability system from raw materials to the finished products was constructed to improve the herbal quality from the entire supply and production chain. The transitivity and traceability system has been established based on quality markers, especially on how to control the production process under Good Engineering Practices, as well as to implement the risk management for quality and process control in herbal medicine production. Copyright © 2018 Elsevier GmbH. All rights reserved.

  14. Reliability issues in PACS

    NASA Astrophysics Data System (ADS)

    Taira, Ricky K.; Chan, Kelby K.; Stewart, Brent K.; Weinberg, Wolfram S.

    1991-07-01

    Reliability is an increasing concern when moving PACS from the experimental laboratory to the clinical environment. Any system downtime may seriously affect patient care. The authors report on the several classes of errors encountered during the pre-clinical release of the PACS during the past several months and present the solutions implemented to handle them. The reliability issues discussed include: (1) environmental precautions, (2) database backups, (3) monitor routines of critical resources and processes, (4) hardware redundancy (networks, archives), and (5) development of a PACS quality control program.

  15. Blended near-optimal tools for flexible water resources decision making

    NASA Astrophysics Data System (ADS)

    Rosenberg, David

    2015-04-01

    State-of-the-art systems analysis techniques focus on efficiently finding optimal solutions. Yet an optimal solution is optimal only for the static modelled issues and managers often seek near-optimal alternatives that address un-modelled or changing objectives, preferences, limits, uncertainties, and other issues. Early on, Modelling to Generate Alternatives (MGA) formalized near-optimal as performance within a tolerable deviation from the optimal objective function value and identified a few maximally-different alternatives that addressed select un-modelled issues. This paper presents new stratified, Monte Carlo Markov Chain sampling and parallel coordinate plotting tools that generate and communicate the structure and full extent of the near-optimal region to an optimization problem. Plot controls allow users to interactively explore region features of most interest. Controls also streamline the process to elicit un-modelled issues and update the model formulation in response to elicited issues. Use for a single-objective water quality management problem at Echo Reservoir, Utah identifies numerous and flexible practices to reduce the phosphorus load to the reservoir and maintain close-to-optimal performance. Compared to MGA, the new blended tools generate more numerous alternatives faster, more fully show the near-optimal region, help elicit a larger set of un-modelled issues, and offer managers greater flexibility to cope in a changing world.

  16. A developmental approach to the treatment of bipolar disorder: IPSRT with an adolescent.

    PubMed

    Crowe, Marie; Inder, Maree; Joyce, Peter; Moor, Stephanie; Carter, Janet; Luty, Sue

    2009-01-01

    This case study explains how a psychotherapy previously used with adults can be used with adolescents by focusing on the specific developmental issues associated with adolescence. Bipolar disorder is a damaging disorder to experience during the developmental phase of adolescence. Interpersonal social rhythm psychotherapy has been developed as an adjunct to medication for managing bipolar disorder and shows some promising outcomes in adults. This is a single case study design drawn from a larger randomised control trial of two psychotherapies for bipolar disorder. The case study addressed the question: How can Interpersonal social rhythm therapy be applied with adolescents who have bipolar disorder? This study used a purposeful sampling process by selecting the youngest adolescent participating in the randomised control trial. All the subject's sessions of Interpersonal social rhythm therapy were taped, transcribed and analysed. The analysis involved describing the process of psychotherapy as it occurred over time, mapping the process as a trajectory across the three phases of psychotherapy experience and focusing the analysis around the impact of bipolar disorder and IPSRT on adolescent developmental issues, specifically the issue of identity development. Interpersonal social rhythm therapy allowed the therapist to address developmental issues within its framework. As a result of participation in the psychotherapy the adolescent was able to manage her mood symptoms and develop a sense of identity that was age-appropriate. Interpersonal social rhythm therapy provided the adolescent in the case study the opportunity to consider what it meant to have bipolar disorder and to integrate this meaning into her sense of self. Bipolar disorder is a chronic and recurring disorder that can have a serious impact on development and functioning. Interpersonal social rhythm therapy provides an approach to nursing care that enables adolescents to improve social functioning.

  17. The MIST /MIUS Integration and Subsystems Test/ laboratory - A testbed for the MIUS /Modular Integrated Utility System/ program

    NASA Technical Reports Server (NTRS)

    Beckham, W. S., Jr.; Keune, F. A.

    1974-01-01

    The MIUS (Modular Integrated Utility System) concept is to be an energy-conserving, economically feasible, integrated community utility system to provide five necessary services: electricity generation, space heating and air conditioning, solid waste processing, liquid waste processing, and residential water purification. The MIST (MIUS Integration and Subsystem Test) integrated system testbed constructed at the Johnson Space Center in Houston includes subsystems for power generation, heating, ventilation, and air conditioning (HVAC), wastewater management, solid waste management, and control and monitoring. The key design issues under study include thermal integration and distribution techniques, thermal storage, integration of subsystems controls and displays, incinerator performance, effluent characteristics, and odor control.

  18. Resiliency of the Multiscale Retinex Image Enhancement Algorithm

    NASA Technical Reports Server (NTRS)

    Rahman, Zia-Ur; Jobson, Daniel J.; Woodell, Glenn A.

    1998-01-01

    The multiscale retinex with color restoration (MSRCR) continues to prove itself in extensive testing to be very versatile automatic image enhancement algorithm that simultaneously provides dynamic range compression, color constancy, and color rendition, However, issues remain with regard to the resiliency of the MSRCR to different image sources and arbitrary image manipulations which may have been applied prior to retinex processing. In this paper we define these areas of concern, provide experimental results, and, examine the effects of commonly occurring image manipulation on retinex performance. In virtually all cases the MSRCR is highly resilient to the effects of both the image source variations and commonly encountered prior image-processing. Significant artifacts are primarily observed for the case of selective color channel clipping in large dark zones in a image. These issues are of concerning the processing of digital image archives and other applications where there is neither control over the image acquisition process, nor knowledge about any processing done on th data beforehand.

  19. A Survey on Optimal Signal Processing Techniques Applied to Improve the Performance of Mechanical Sensors in Automotive Applications

    PubMed Central

    Hernandez, Wilmar

    2007-01-01

    In this paper a survey on recent applications of optimal signal processing techniques to improve the performance of mechanical sensors is made. Here, a comparison between classical filters and optimal filters for automotive sensors is made, and the current state of the art of the application of robust and optimal control and signal processing techniques to the design of the intelligent (or smart) sensors that today's cars need is presented through several experimental results that show that the fusion of intelligent sensors and optimal signal processing techniques is the clear way to go. However, the switch between the traditional methods of designing automotive sensors and the new ones cannot be done overnight because there are some open research issues that have to be solved. This paper draws attention to one of the open research issues and tries to arouse researcher's interest in the fusion of intelligent sensors and optimal signal processing techniques.

  20. Monetization of Nigeria coal by conversion to hydrocarbon fuels through Fischer-Tropsch process

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Oguejiofor, G.C.

    Given the instability of crude oil prices and the disruptions in crude oil supply chains, this article offers a complementing investment proposal through diversification of Nigeria's energy source and dependence. Therefore, the following issues were examined and reported: A comparative survey of coal and hydrocarbon reserve bases in Nigeria was undertaken and presented. An excursion into the economic, environmental, and technological justifications for the proposed diversification and roll-back to coal-based resource was also undertaken and presented. The technology available for coal beneficiation for environmental pollution control was reviewed and reported. The Fischer-Tropsch synthesis and its advances into Sasol's slurry phasemore » distillate process were reviewed. Specifically, the adoption of Sasol's advanced synthol process and the slurry phase distillate process were recommended as ways of processing the products of coal gasification. The article concludes by discussing all the above-mentioned issues with regard to value addition as a means of wealth creation and investment.« less

  1. Narrative communication in cancer prevention and control: a framework to guide research and application.

    PubMed

    Kreuter, Matthew W; Green, Melanie C; Cappella, Joseph N; Slater, Michael D; Wise, Meg E; Storey, Doug; Clark, Eddie M; O'Keefe, Daniel J; Erwin, Deborah O; Holmes, Kathleen; Hinyard, Leslie J; Houston, Thomas; Woolley, Sabra

    2007-06-01

    Narrative forms of communication-including entertainment education, journalism, literature, testimonials, and storytelling-are emerging as important tools for cancer prevention and control. To stimulate critical thinking about the role of narrative in cancer communication and promote a more focused and systematic program of research to understand its effects, we propose a typology of narrative application in cancer control. We assert that narrative has four distinctive capabilities: overcoming resistance, facilitating information processing, providing surrogate social connections, and addressing emotional and existential issues. We further assert that different capabilities are applicable to different outcomes across the cancer control continuum (e.g., prevention, detection, diagnosis, treatment, survivorship). This article describes the empirical evidence and theoretical rationale supporting propositions in the typology, identifies variables likely to moderate narrative effects, raises ethical issues to be addressed when using narrative communication in cancer prevention and control efforts, and discusses potential limitations of using narrative in this way. Future research needs based on these propositions are outlined and encouraged.

  2. Design requirements for SRB production control system. Volume 2: System requirements and conceptual description

    NASA Technical Reports Server (NTRS)

    1981-01-01

    In the development of the business system for the SRB automated production control system, special attention had to be paid to the unique environment posed by the space shuttle. The issues posed by this environment, and the means by which they were addressed, are reviewed. The change in management philosphy which will be required as NASA switches from one-of-a-kind launches to multiple launches is discussed. The implications of the assembly process on the business system are described. These issues include multiple missions, multiple locations and facilities, maintenance and refurbishment, multiple sources, and multiple contractors. The implications of these aspects on the automated production control system are reviewed including an assessment of the six major subsystems, as well as four other subsystem. Some general system requirements which flow through the entire business system are described.

  3. Connected cane: Tactile button input for controlling gestures of iOS voiceover embedded in a white cane.

    PubMed

    Batterman, Jared M; Martin, Vincent F; Yeung, Derek; Walker, Bruce N

    2018-01-01

    Accessibility of assistive consumer devices is an emerging research area with potential to benefit both users with and without visual impairments. In this article, we discuss the research and evaluation of using a tactile button interface to control an iOS device's native VoiceOver Gesture navigations (Apple Accessibility, 2014). This research effort identified potential safety and accessibility issues for users trying to interact and control their touchscreen mobile iOS devices while traveling independently. Furthermore, this article discusses the participatory design process in creating a solution that aims to solve issues in utilizing a tactile button interface in a novel device. The overall goal of this study is to enable visually impaired white cane users to access their mobile iOS device's capabilities navigation aids more safely and efficiently on the go.

  4. Availability Control for Means of Transport in Decisive Semi-Markov Models of Exploitation Process

    NASA Astrophysics Data System (ADS)

    Migawa, Klaudiusz

    2012-12-01

    The issues presented in this research paper refer to problems connected with the control process for exploitation implemented in the complex systems of exploitation for technical objects. The article presents the description of the method concerning the control availability for technical objects (means of transport) on the basis of the mathematical model of the exploitation process with the implementation of the decisive processes by semi-Markov. The presented method means focused on the preparing the decisive for the exploitation process for technical objects (semi-Markov model) and after that specifying the best control strategy (optimal strategy) from among possible decisive variants in accordance with the approved criterion (criteria) of the activity evaluation of the system of exploitation for technical objects. In the presented method specifying the optimal strategy for control availability in the technical objects means a choice of a sequence of control decisions made in individual states of modelled exploitation process for which the function being a criterion of evaluation reaches the extreme value. In order to choose the optimal control strategy the implementation of the genetic algorithm was chosen. The opinions were presented on the example of the exploitation process of the means of transport implemented in the real system of the bus municipal transport. The model of the exploitation process for the means of transports was prepared on the basis of the results implemented in the real transport system. The mathematical model of the exploitation process was built taking into consideration the fact that the model of the process constitutes the homogenous semi-Markov process.

  5. Cognitive issues in autonomous spacecraft-control operations: An investigation of software-mediated decision making in a scaled environment

    NASA Astrophysics Data System (ADS)

    Murphy, Elizabeth Drummond

    As advances in technology are applied in complex, semi-automated domains, human controllers are distanced from the controlled process. This physical and psychological distance may both facilitate and degrade human performance. To investigate cognitive issues in spacecraft ground-control operations, the present experimental research was undertaken. The primary issue concerned the ability of operations analysts who do not monitor operations to make timely, accurate decisions when autonomous software calls for human help. Another key issue involved the potential effects of spatial-visualization ability (SVA) in environments that present data in graphical formats. Hypotheses were derived largely from previous findings and predictions in the literature. Undergraduate psychology students were assigned at random to a monitoring condition or an on-call condition in a scaled environment. The experimental task required subjects to decide on the veracity of a problem diagnosis delivered by a software process on-board a simulated spacecraft. To support decision-making, tabular and graphical data displays presented information on system status. A level of software confidence in the problem diagnosis was displayed, and subjects reported their own level of confidence in their decisions. Contrary to expectations, the performance of on-call subjects did not differ significantly from that of continuous monitors. Analysis yielded a significant interaction of sex and condition: Females in the on-call condition had the lowest mean accuracy. Results included a preference for bar charts over line graphs and faster performance with tables than with line graphs. A significant correlation was found between subjective confidence and decision accuracy. SVA was found to be predictive of accuracy but not speed; and SVA was found to be a stronger predictor of performance for males than for females. Low-SVA subjects reported that they relied more on software confidence than did medium- or high-SVA subjects. These and other findings have implications for the design of user interfaces to support human decision-making in on-call situations and to accommodate low-SVA users.

  6. Biological and social influences on cognitive control processes dependent on prefrontal cortex

    PubMed Central

    Diamond, Adele

    2014-01-01

    Cognitive control functions (“executive functions” [EFs] such as attentional control, self-regulation, working memory, and inhibition) that depend on prefrontal cortex (PFC) are critical for success in school and in life. Many children begin school lacking needed EF skills. Disturbances in EFs occur in many mental health disorders, such as ADHD and depression. This chapter addresses modulation of EFs by biology (genes and neurochemistry) and the environment (including school programs) with implications for clinical disorders and for education. Unusual properties of the prefrontal dopamine system contribute to PFC’s vulnerability to environmental and genetic variations that have little effect elsewhere. EFs depend on a late-maturing brain region (PFC), yet they can be improved even in infants and preschoolers, without specialists or fancy equipment. Research shows that activities often squeezed out of school curricula (play, physical education, and the arts) rather than detracting from academic achievement help improve EFs and enhance academic outcomes. Such practices may also head off problems before they lead to diagnoses of EF impairments, including ADHD. Many issues are not simply education issues or health issues; they are both. PMID:21489397

  7. Data Quality Assurance and Control for AmeriFlux Network at CDIAC, ORNL

    NASA Astrophysics Data System (ADS)

    Shem, W.; Boden, T.; Krassovski, M.; Yang, B.

    2014-12-01

    The Carbon Dioxide Information Analysis Center (CDIAC) at the Oak Ridge National Laboratory (ORNL) serves as the long-term data repository for the AmeriFlux network. Datasets currently available include hourly or half-hourly meteorological and flux observations, biological measurement records, and synthesis data products. Currently there is a lack of standardized nomenclature and specifically designed procedures for data quality assurance/control in processing and handling micrometeorological and ecological data at individual flux sites. CDIAC's has bridged this gap by providing efficient and accurate procedures for data quality control and standardization of the results for easier assimilation by the models used in climate science. In this presentation we highlight the procedures we have put in place to scrutinize continuous flux and meteorological data within Ameriflux network. We itemize some basic data quality issues that we have observed over the past years and include some examples of typical data quality issues. Such issues, e.g., incorrect time-stamping, poor calibration or maintenance of instruments, missing or incomplete metadata and others that are commonly over-looked by PI's, invariably impact the time-series observations.

  8. Model reduction in integrated controls-structures design

    NASA Technical Reports Server (NTRS)

    Maghami, Peiman G.

    1993-01-01

    It is the objective of this paper to present a model reduction technique developed for the integrated controls-structures design of flexible structures. Integrated controls-structures design problems are typically posed as nonlinear mathematical programming problems, where the design variables consist of both structural and control parameters. In the solution process, both structural and control design variables are constantly changing; therefore, the dynamic characteristics of the structure are also changing. This presents a problem in obtaining a reduced-order model for active control design and analysis which will be valid for all design points within the design space. In other words, the frequency and number of the significant modes of the structure (modes that should be included) may vary considerably throughout the design process. This is also true as the locations and/or masses of the sensors and actuators change. Moreover, since the number of design evaluations in the integrated design process could easily run into thousands, any feasible order-reduction method should not require model reduction analysis at every design iteration. In this paper a novel and efficient technique for model reduction in the integrated controls-structures design process, which addresses these issues, is presented.

  9. Micro guidance and control technology overview

    NASA Technical Reports Server (NTRS)

    Kissel, Glen J.; Hadaegh, Fred Y.

    1993-01-01

    This paper gives an overview of micro-guidance and control technologies and in the process previews of the technology/user and systems issues presented in the guidance and control session at the workshop. We first present a discussion of the advantages of using micro-guidance and control components and then detail six micro-guidance and control thrusts that could have a revolutionary impact on space missions and systems. Specific technologies emerging in the micro-guidance and control field will be examined. These technologies fall into two broad categories: micro-attitude determination (inertial and celestial) and micro-actuation, control and sensing. Finally, the scope of the workshop's guidance and control panel are presented.

  10. Privacy aware access controls for medical data disclosure on European healthgrids.

    PubMed

    Rahmouni, Hanene Boussi; Solomonides, Tony; Mont, Marco Casassa; Shiu, Simon

    2010-01-01

    To be processed within a healthgrid environment, medical data goes through a complete lifecycle and several stages until it is finally used for the primary reason it has been collected for. This stage is not always the final occurrence of when the data would have been manipulated. The data could rather continue to be needed for secondary purposes of legitimate or non legitimate nature. Although other privacy issues are related to the processing of patient data while it is residing on a healthgrid environment, the control of data disclosure is our primary interest. When sharing medical data between different Healthcare and biomedical research organizations in Europe, it is important that the different parties involved in the sharing handle the data in the same way indicated by the legislation of the member state where the data was originally collected as the requirements might differ from one state to another. Privacy requirements, such as patient consent, may be subject to conflicting conditions between different national frameworks as well as between different legal and ethical frameworks within a single member state. These circumstances have made the compliance management process in European healthgrid very challenging. In this paper we are presenting an approach to tackle these issues by relying on several technologies contained in the semantic web stack. Our work suggests a direct mapping from high level legislation on privacy and data protection to operational level privacy aware controls. Additionally we suggest an architecture for the enforcement of these controls on access control models adopted by healthgrids security infrastructures.

  11. TRANSPORT AND FATE OF CONTAMINANTS IN THE SUBSURFACE

    EPA Science Inventory

    This publication is based on a series of t.technology Transfer seminars that were conducted in 1987 and 1988. The document provides an overview of many of the issues associated with the physical, chemical and biological processes that control contaminant transport in the subsurfa...

  12. 40 CFR 51.367 - Inspector training and licensing or certification.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) Public relations; and (ix) Safety and health issues related to the inspection process. (2) If inspector... effects; (ii) The purpose, function, and goal of the inspection program; (iii) Inspection regulations and... control device function, configuration, and inspection; (vi) Test equipment operation, calibration, and...

  13. Guideline for Software Documentation Management.

    ERIC Educational Resources Information Center

    National Bureau of Standards (DOC), Washington, DC.

    Designed as a basic reference for federal personnel concerned with the development, maintenance, enhancement, control, and management of computer-based systems, this manual provides a general overview of the software development process and software documentation issues so that managers can assess their own documentation requirements. Reference is…

  14. Development of process control capability through the Browns Ferry Integrated Computer System using Reactor Water Clanup System as an example. Final report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Smith, J.; Mowrey, J.

    1995-12-01

    This report describes the design, development and testing of process controls for selected system operations in the Browns Ferry Nuclear Plant (BFNP) Reactor Water Cleanup System (RWCU) using a Computer Simulation Platform which simulates the RWCU System and the BFNP Integrated Computer System (ICS). This system was designed to demonstrate the feasibility of the soft control (video touch screen) of nuclear plant systems through an operator console. The BFNP Integrated Computer System, which has recently. been installed at BFNP Unit 2, was simulated to allow for operator control functions of the modeled RWCU system. The BFNP Unit 2 RWCU systemmore » was simulated using the RELAP5 Thermal/Hydraulic Simulation Model, which provided the steady-state and transient RWCU process variables and simulated the response of the system to control system inputs. Descriptions of the hardware and software developed are also included in this report. The testing and acceptance program and results are also detailed in this report. A discussion of potential installation of an actual RWCU process control system in BFNP Unit 2 is included. Finally, this report contains a section on industry issues associated with installation of process control systems in nuclear power plants.« less

  15. Crustal permeability: Introduction to the special issue

    USGS Publications Warehouse

    Ingebritsen, Steven E.; Gleeson, Tom

    2015-01-01

    The topic of crustal permeability is of broad interest in light of the controlling effect of permeability on diverse geologic processes and also timely in light of the practical challenges associated with emerging technologies such as hydraulic fracturing for oil and gas production (‘fracking’), enhanced geothermal systems, and geologic carbon sequestration. This special issue of Geofluids is also motivated by the historical dichotomy between the hydrogeologic concept of permeability as a static material property that exerts control on fluid flow and the perspective of economic geologists, geophysicists, and crustal petrologists who have long recognized permeability as a dynamic parameter that changes in response to tectonism, fluid production, and geochemical reactions. Issues associated with fracking, enhanced geothermal systems, and geologic carbon sequestration have already begun to promote a constructive dialog between the static and dynamic views of permeability, and here we have made a conscious effort to include both viewpoints. This special issue also focuses on the quantification of permeability, encompassing both direct measurement of permeability in the uppermost crust and inferential permeability estimates, mainly for the deeper crust.

  16. Continuous welding of unidirectional fiber reinforced thermoplastic tape material

    NASA Astrophysics Data System (ADS)

    Schledjewski, Ralf

    2017-10-01

    Continuous welding techniques like thermoplastic tape placement with in situ consolidation offer several advantages over traditional manufacturing processes like autoclave consolidation, thermoforming, etc. However, still there is a need to solve several important processing issues before it becomes a viable economic process. Intensive process analysis and optimization has been carried out in the past through experimental investigation, model definition and simulation development. Today process simulation is capable to predict resulting consolidation quality. Effects of material imperfections or process parameter variations are well known. But using this knowledge to control the process based on online process monitoring and according adaption of the process parameters is still challenging. Solving inverse problems and using methods for automated code generation allowing fast implementation of algorithms on targets are required. The paper explains the placement technique in general. Process-material-property-relationships and typical material imperfections are described. Furthermore, online monitoring techniques and how to use them for a model based process control system are presented.

  17. On-board processing architectures for satellite B-ISDN services

    NASA Technical Reports Server (NTRS)

    Inukai, Thomas; Shyy, Dong-Jye; Faris, Faris

    1991-01-01

    Onboard baseband processing architectures for future satellite broadband integrated services digital networks (B-ISDN's) are addressed. To assess the feasibility of implementing satellite B-ISDN services, critical design issues, such as B-ISDN traffic characteristics, transmission link design, and a trade-off between onboard circuit and fast packet switching, are analyzed. Examples of the two types of switching mechanisms and potential onboard network control functions are presented. A sample network architecture is also included to illustrate a potential onboard processing system.

  18. On-board processing satellite network architectures for broadband ISDN

    NASA Technical Reports Server (NTRS)

    Inukai, Thomas; Faris, Faris; Shyy, Dong-Jye

    1992-01-01

    Onboard baseband processing architectures for future satellite broadband integrated services digital networks (B-ISDN's) are addressed. To assess the feasibility of implementing satellite B-ISDN services, critical design issues, such as B-ISDN traffic characteristics, transmission link design, and a trade-off between onboard circuit and fast packet switching, are analyzed. Examples of the two types of switching mechanisms and potential onboard network control functions are presented. A sample network architecture is also included to illustrate a potential onboard processing system.

  19. SPECIAL ISSUE ON OPTICAL PROCESSING OF INFORMATION: Information transmission systems based on two-mode lasers with controlled emission frequencies

    NASA Astrophysics Data System (ADS)

    Naumov, N. V.; Petrovskii, V. N.; Protsenko, E. D.; Shananin, R. A.

    1995-10-01

    Various information transmission systems, based on two-mode lasers with controlled emission frequencies, are proposed. It is suggested that these systems can be implemented by modulation of the intermode spacing of a two-mode laser. An experimental investigation is reported of frequency control methods. It is shown that these methods should make it possible to construct information transmission systems with high transmission rates subject to weak nonlinear distortions of the information-carrying signal.

  20. Dynamic Controllability and Dispatchability Relationships

    NASA Technical Reports Server (NTRS)

    Morris, Paul Henry

    2014-01-01

    An important issue for temporal planners is the ability to handle temporal uncertainty. Recent papers have addressed the question of how to tell whether a temporal network is Dynamically Controllable, i.e., whether the temporal requirements are feasible in the light of uncertain durations of some processes. We present a fast algorithm for Dynamic Controllability. We also note a correspondence between the reduction steps in the algorithm and the operations involved in converting the projections to dispatchable form. This has implications for the complexity for sparse networks.

  1. Enhanced High Performance Power Compensation Methodology by IPFC Using PIGBT-IDVR

    PubMed Central

    Arumugom, Subramanian; Rajaram, Marimuthu

    2015-01-01

    Currently, power systems are involuntarily controlled without high speed control and are frequently initiated, therefore resulting in a slow process when compared with static electronic devices. Among various power interruptions in power supply systems, voltage dips play a central role in causing disruption. The dynamic voltage restorer (DVR) is a process based on voltage control that compensates for line transients in the distributed system. To overcome these issues and to achieve a higher speed, a new methodology called the Parallel IGBT-Based Interline Dynamic Voltage Restorer (PIGBT-IDVR) method has been proposed, which mainly spotlights the dynamic processing of energy reloads in common dc-linked energy storage with less adaptive transition. The interline power flow controller (IPFC) scheme has been employed to manage the power transmission between the lines and the restorer method for controlling the reactive power in the individual lines. By employing the proposed methodology, the failure of a distributed system has been avoided and provides better performance than the existing methodologies. PMID:26613101

  2. CHAM: weak signals detection through a new multivariate algorithm for process control

    NASA Astrophysics Data System (ADS)

    Bergeret, François; Soual, Carole; Le Gratiet, B.

    2016-10-01

    Derivatives technologies based on core CMOS processes are significantly aggressive in term of design rules and process control requirements. Process control plan is a derived from Process Assumption (PA) calculations which result in a design rule based on known process variability capabilities, taking into account enough margin to be safe not only for yield but especially for reliability. Even though process assumptions are calculated with a 4 sigma known process capability margin, efficient and competitive designs are challenging the process especially for derivatives technologies in 40 and 28nm nodes. For wafer fab process control, PA are declined in monovariate (layer1 CD, layer2 CD, layer2 to layer1 overlay, layer3 CD etc….) control charts with appropriated specifications and control limits which all together are securing the silicon. This is so far working fine but such system is not really sensitive to weak signals coming from interactions of multiple key parameters (high layer2 CD combined with high layer3 CD as an example). CHAM is a software using an advanced statistical algorithm specifically designed to detect small signals, especially when there are many parameters to control and when the parameters can interact to create yield issues. In this presentation we will first present the CHAM algorithm, then the case-study on critical dimensions, with the results, and we will conclude on future work. This partnership between Ippon and STM is part of E450LMDAP, European project dedicated to metrology and lithography development for future technology nodes, especially 10nm.

  3. Power MEMS Development

    DTIC Science & Technology

    2011-05-01

    wafer pair through further processing. Initial cracking issues were identified due to liquid penetration between the wafers during wet processing...free-standing MCD films we needed to address crack formation in the diamond and the Si substrate, which we observed during our initial growths due to...NCD film grown using the heated stage, and finally the thick MCD film grown on the cooled stage. We also found that the control of cracking in the

  4. Validation Methods for Fault-Tolerant avionics and control systems, working group meeting 1

    NASA Technical Reports Server (NTRS)

    1979-01-01

    The proceedings of the first working group meeting on validation methods for fault tolerant computer design are presented. The state of the art in fault tolerant computer validation was examined in order to provide a framework for future discussions concerning research issues for the validation of fault tolerant avionics and flight control systems. The development of positions concerning critical aspects of the validation process are given.

  5. A cybernetic model of global personality traits.

    PubMed

    Van Egeren, Lawrence F

    2009-05-01

    Neurobehavioral studies of human and animal temperament have shed light on how individual personality traits influence human actions. This approach, however, leaves open questions about how the entire system of traits and temperaments function together to exercise control. To address this key issue, I describe a cybernetic model of control and then apply it to the Big Five (B5) personality traits. Employing evidence from descriptive trait terms, temperamental behavioral processes associated with traits, and empirical correlates of traits, I relate distinct cybernetic processes of self-regulation to the B5 traits. The B5 traits broadly parallel basic cybernetic self-regulation processes. For example, the core behavior activation property of the B5 Extraversion trait can be mapped onto the device output function of automated cybernetic control systems. Implications and limitations of interpreting personality traits in self-regulation terms are discussed.

  6. Atmosphere Explorer control system software (version 2.0)

    NASA Technical Reports Server (NTRS)

    Mocarsky, W.; Villasenor, A.

    1973-01-01

    The Atmosphere Explorer Control System (AECS) was developed to provide automatic computer control of the Atmosphere Explorer spacecraft and experiments. The software performs several vital functions, such as issuing commands to the spacecraft and experiments, receiving and processing telemetry data, and allowing for extensive data processing by experiment analysis programs. The AECS was written for a 48K XEROX Data System Sigma 5 computer, and coexists in core with the XDS Real-time Batch Monitor (RBM) executive system. RBM is a flexible operating system designed for a real-time foreground/background environment, and hence is ideally suited for this application. Existing capabilities of RBM have been used as much as possible by AECS to minimize programming redundancy. The most important functions of the AECS are to send commands to the spacecraft and experiments, and to receive, process, and display telemetry data.

  7. Managing the transcription revolution. Industry forces shape future of field.

    PubMed

    Faulkner, Scott D

    2003-01-01

    You may be struggling with contract issues with a vendor. Or maybe you're contemplating the pros and cons of working with outsource, at-home, or overseas transcriptionists. It's a fact: if transcription processes aren't working efficiently, the entire HIM department may be adversely affected. Factor in additional concerns such as data capture for electronic health records, compliance, and patient safety, and the importance of ensuring quality and cost-efficient transcription becomes even more apparent. To help you answer some of these questions, the Journal of AHIMA is launching a four-part series dedicated to transcription issues from the HIM professional's point of view. In this issue, we begin with MTIA president Scott Faulkner's overview of the industry and where it's going next. In upcoming issues, other experts will look at controlling cost and monitoring quality, navigating new technologies, and dealing with contract-related issues.

  8. Transboundary Movements of Hazardous Wastes. A Comparative Analysis of Policy Options to Control the International Waste Trade.

    ERIC Educational Resources Information Center

    Hilz, Christoph; Ehrenfeld, John R.

    1991-01-01

    Several policy frameworks for managing hazardous waste import/export are examined with respect to economic issues, environmental sustainability, and administrative feasibility and effectiveness. Several recommendations for improving the present instrument and implementing process are offered. (Author/CW)

  9. Schoolhouse & Statehouse.

    ERIC Educational Resources Information Center

    Urschel, Jane W.

    2002-01-01

    Interviews with 11 Colorado state legislators about their views on local control reveal they have no fear of pushing the constitutional envelope when it comes to legislating school policy. School board members must get involved in the legislative process, whether by lobbying legislators on behalf of important education issues or testifying as…

  10. BIOLOGICAL WASTE AIR TREATMENT IN BIOTRICKLING FILTERS. (R825392)

    EPA Science Inventory

    Abstract

    Recent studies in the area of biological waste air treatment in biotrickling filters have addressed fundamental key issues, such as biofilm architecture, microbiology of the process culture and means to control accumulation of biomass. The results from these s...

  11. Input-output oriented computation algorithms for the control of large flexible structures

    NASA Technical Reports Server (NTRS)

    Minto, K. D.

    1989-01-01

    An overview is given of work in progress aimed at developing computational algorithms addressing two important aspects in the control of large flexible space structures; namely, the selection and placement of sensors and actuators, and the resulting multivariable control law design problem. The issue of sensor/actuator set selection is particularly crucial to obtaining a satisfactory control design, as clearly a poor choice will inherently limit the degree to which good control can be achieved. With regard to control law design, the researchers are driven by concerns stemming from the practical issues associated with eventual implementation of multivariable control laws, such as reliability, limit protection, multimode operation, sampling rate selection, processor throughput, etc. Naturally, the burden imposed by dealing with these aspects of the problem can be reduced by ensuring that the complexity of the compensator is minimized. Our approach to these problems is based on extensions to input/output oriented techniques that have proven useful in the design of multivariable control systems for aircraft engines. In particular, researchers are exploring the use of relative gain analysis and the condition number as a means of quantifying the process of sensor/actuator selection and placement for shape control of a large space platform.

  12. Major depression is associated with impaired processing of emotion in music as well as in facial and vocal stimuli.

    PubMed

    Naranjo, C; Kornreich, C; Campanella, S; Noël, X; Vandriette, Y; Gillain, B; de Longueville, X; Delatte, B; Verbanck, P; Constant, E

    2011-02-01

    The processing of emotional stimuli is thought to be negatively biased in major depression. This study investigates this issue using musical, vocal and facial affective stimuli. 23 depressed in-patients and 23 matched healthy controls were recruited. Affective information processing was assessed through musical, vocal and facial emotion recognition tasks. Depression, anxiety level and attention capacity were controlled. The depressed participants demonstrated less accurate identification of emotions than the control group in all three sorts of emotion-recognition tasks. The depressed group also gave higher intensity ratings than the controls when scoring negative emotions, and they were more likely to attribute negative emotions to neutral voices and faces. Our in-patient group might differ from the more general population of depressed adults. They were all taking anti-depressant medication, which may have had an influence on their emotional information processing. Major depression is associated with a general negative bias in the processing of emotional stimuli. Emotional processing impairment in depression is not confined to interpersonal stimuli (faces and voices), being also present in the ability to feel music accurately. © 2010 Elsevier B.V. All rights reserved.

  13. Cognitive process modelling of controllers in en route air traffic control.

    PubMed

    Inoue, Satoru; Furuta, Kazuo; Nakata, Keiichi; Kanno, Taro; Aoyama, Hisae; Brown, Mark

    2012-01-01

    In recent years, various efforts have been made in air traffic control (ATC) to maintain traffic safety and efficiency in the face of increasing air traffic demands. ATC is a complex process that depends to a large degree on human capabilities, and so understanding how controllers carry out their tasks is an important issue in the design and development of ATC systems. In particular, the human factor is considered to be a serious problem in ATC safety and has been identified as a causal factor in both major and minor incidents. There is, therefore, a need to analyse the mechanisms by which errors occur due to complex factors and to develop systems that can deal with these errors. From the cognitive process perspective, it is essential that system developers have an understanding of the more complex working processes that involve the cooperative work of multiple controllers. Distributed cognition is a methodological framework for analysing cognitive processes that span multiple actors mediated by technology. In this research, we attempt to analyse and model interactions that take place in en route ATC systems based on distributed cognition. We examine the functional problems in an ATC system from a human factors perspective, and conclude by identifying certain measures by which to address these problems. This research focuses on the analysis of air traffic controllers' tasks for en route ATC and modelling controllers' cognitive processes. This research focuses on an experimental study to gain a better understanding of controllers' cognitive processes in air traffic control. We conducted ethnographic observations and then analysed the data to develop a model of controllers' cognitive process. This analysis revealed that strategic routines are applicable to decision making.

  14. SPECIAL ISSUE ON OPTICAL PROCESSING OF INFORMATION: Characteristics of surface-plasmon liquid-crystal light modulators operating under phase modulation conditions

    NASA Astrophysics Data System (ADS)

    Nazvanov, V. F.; Afonin, O. A.; Grebennikov, A. I.

    1995-10-01

    Electrically and optically controlled liquid-crystal light modulators based on surface plasmons were developed and investigated in an ellipsometric optical system. The characteristics of these modulators were determined and compared under phase and amplitude modulation conditions.

  15. Ground Water Issue Paper: Synthesis Report on State of Understanding of Chlorinated Solvent Transformation

    EPA Science Inventory

    The U.S. EPA (1999) provided clarification of its policy on the application of MNA as a remedy for contaminated sites, and defines this alternative as “the reliance on natural attenuation processes (within the context of a carefully controlled and monitored site cleanup approach)...

  16. BIOGEOCHEMICAL PROCESSES CONTROLLING ARSENIC SPECIATION AND BIOTRANSFORMATION IN GRANULAR FERRIC HYDROXIDE COATED SAND

    EPA Science Inventory

    Arsenic mobilization from solid phase Fe (III) hydroxides is an issue of concern, as water-borne arsenic can migrate into pristine environments, endangering aquatic and human life. In general, metal oxide (hydroxides) exerts a dominating effect on the fate and transport of arseni...

  17. Bits and Pieces--Copyright Law and Australian Libraries in 1997.

    ERIC Educational Resources Information Center

    Herd, Annabelle

    1997-01-01

    Discusses issues in Australian libraries related to copyright in the digital environment. Examines what constitutes a digital copy; exceptions/limitations; the extent of liability of those who communicate/transmit digital copyright-protected works; how uses of material can be monitored/controlled; and the process of copyright reform in Australia…

  18. Footing, Resistance and Control: Negotiating a Traffic Citation

    ERIC Educational Resources Information Center

    Smith, Wendy B.

    2010-01-01

    The purpose of this article is to demonstrate the micro-interactional processes by which powerful and powerless identities are locally reconstructed. The article specifically examines the interplay between consent and resistance to law-breaking identities. Data consist of transcripts of 45 incidents in which highway patrol officers issue traffic…

  19. Systems autonomy

    NASA Technical Reports Server (NTRS)

    Lum, Henry, Jr.

    1988-01-01

    Information on systems autonomy is given in viewgraph form. Information is given on space systems integration, intelligent autonomous systems, automated systems for in-flight mission operations, the Systems Autonomy Demonstration Project on the Space Station Thermal Control System, the architecture of an autonomous intelligent system, artificial intelligence research issues, machine learning, and real-time image processing.

  20. Aerospace System Unified Life Cycle Engineering Producibility Measurement Issues

    DTIC Science & Technology

    1989-05-01

    Control .................................................................. 11-9 5 . C o st...in the development process; these computer -aided models offer clarity approaching that of a prototype model. Once a part geometry is represented...of part geometry , allowing manufacturability evaluation and possibly other computer -integrated manufacturing (CIM) tasks. (Other papers that discuss

  1. Management of Student Aid.

    ERIC Educational Resources Information Center

    Nevin, Jeanne, Ed.

    The principles, practices, responsibilities, and controls in student financial aid are described in this manual. It traces the flow of funds, management activities, and legal issues as they occur in the process. The emphasis is on sound management principles of a general and permanent nature rather than on specific government requirements that may…

  2. 34 CFR 361.16 - Establishment of an independent commission or a state rehabilitation council.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-controlled by persons who— (A) Are individuals with physical or mental impairments that substantially limit...; (iii) Includes family members, advocates, or other representatives of individuals with mental... this part; and (C) Copies of due process hearing decisions issued under this part and transmitted in a...

  3. Electronic Publishing and Document Delivery; A Case Study of Commercial Information Services on the Internet.

    ERIC Educational Resources Information Center

    Abbott, Anthony

    1992-01-01

    Discusses the electronic publishing activities of Meckler Publishing on the Internet, including a publications catalog, an electronic journal, and tables of contents databases. Broader issues of commercial network publishing are also addressed, including changes in the research process, changes in publishing, bibliographic control,…

  4. 76 FR 55380 - SFIREG EQI Working Committee; Notice of Public Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-07

    ... Association of American Pesticide Control Officials (AAPCO)/State FIFRA Issues Research and Evaluation Group... and sets forth the tentative agenda topics. DATES: The meeting will be held on Monday, October 17.... II. Tentative Agenda Topics 1. Endangered Species Act--``the services'' on their process and...

  5. Exploring Filipino Adolescents' Perceptions of the Legitimacy of Parental Authority over Academic Behaviors

    ERIC Educational Resources Information Center

    Bernardo, Allan B. I.

    2010-01-01

    Filipino adolescents' perceptions regarding the legitimacy of parental control over academic behaviors was investigated. It was assumed that the adolescents would differentiate between the issues inherent in various types or domains of academic behaviors. The results revealed three domains of academic behaviors: learning processes, college major…

  6. 76 FR 20034 - Calvin Ramsey, M.D.; Revocation of Registration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-11

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 10-25] Calvin Ramsey, M.D... Control, Drug Enforcement Administration, issued an Order to Show Cause to Calvin Ramsey, M.D. (Respondent.... Respondent's Resp., at 1. Therein, Respondent asserted that ``[d]ue process dictates that this Court must...

  7. Factors Affecting Item Difficulty in English Listening Comprehension Tests

    ERIC Educational Resources Information Center

    Sung, Pei-Ju; Lin, Su-Wei; Hung, Pi-Hsia

    2015-01-01

    Task difficulty is a critical issue affecting test developers. Controlling or balancing the item difficulty of an assessment improves its validity and discrimination. Test developers construct tests from the cognitive perspective, by making the test constructing process more scientific and efficient; thus, the scores obtained more precisely…

  8. Olfactory Processing in Male Children with Autism: Atypical Odor Threshold and Identification

    ERIC Educational Resources Information Center

    Muratori, Filippo; Tonacci, Alessandro; Billeci, Lucia; Catalucci, Tiziana; Igliozzi, Roberta; Calderoni, Sara; Narzisi, Antonio

    2017-01-01

    Sensory issues are of great interest in ASD diagnosis. However, their investigation is mainly based on external observation (parent reports), with methodological limitations. Unobtrusive olfactory assessment allows studying autism neurosensoriality. Here, 20 male children with high-functioning ASD and 20 matched controls were administered a…

  9. Development of intelligent robots - Achievements and issues

    NASA Astrophysics Data System (ADS)

    Nitzan, D.

    1985-03-01

    A flexible, intelligent robot is regarded as a general purpose machine system that may include effectors, sensors, computers, and auxiliary equipment and, like a human, can perform a variety of tasks under unpredictable conditions. Development of intelligent robots is essential for increasing the growth rate of today's robot population in industry and elsewhere. Robotics research and development topics include manipulation, end effectors, mobility, sensing (noncontact and contact), adaptive control, robot programming languages, and manufacturing process planning. Past achievements and current issues related to each of these topics are described briefly.

  10. Waste management in space: a NASA symposium. Special issue

    NASA Technical Reports Server (NTRS)

    Wydeven, T. (Principal Investigator)

    1991-01-01

    This special issue contains papers from the NASA Symposium on Waste Processing for Advanced Life Support, which was held at NASA Ames Research Center on September 11-13, 1990. Specialists in waste management from academia, government, and industry convened to exchange ideas and advise NASA in developing effective methods for waste management in a Controlled Ecological Life Support System (CELSS). Innovative and well-established methods were presented to assist in developing and managing wastes in closed systems for future long-duration space missions, especially missions to Mars.

  11. Senate and INF ratification

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jones, D.T.

    1992-11-16

    The Intermediate-Range Nuclear Forces (INF) Treaty represented one of the first major accomplishments of the post-cold war era. In contrast to all arms control agreements which preceded it, INF resulted in the elimination of a whole category of weapons systems. The author describes and analyzes many issues which impinged on the Senate ratification process and stimulated intense political debate. In addition to national and international security questions, these issues involved constitutional, political, jurisdictional, and bureaucratic factors. The author concludes with lessons and recommendations for more expeditious ratification for future agreements.

  12. Development of optical-electronic system for the separation of cullet

    NASA Astrophysics Data System (ADS)

    Solovey, Alexey A.; Alekhin, Artem A.

    2017-06-01

    Broken glass being the waste in many fields of production is usually used as a raw material in the production of construction materials. The purity level of collected and processed glass cullet, as a rule, is quite low. Direct usage of these materials without preliminary processing leads to the emergence of defects in the end product or sometimes even to technological downtime. That's why purity control of cullet should be strictly verified. The study shows the method of construction and requirements for an optical-electronic system designed for cullet separation. Moreover, the author proposes a registration channel scheme and shows a scheme of control exposure area. Also the issues of image processing for the implementation of a typical system are examined.

  13. Machine Learning: A Crucial Tool for Sensor Design

    PubMed Central

    Zhao, Weixiang; Bhushan, Abhinav; Santamaria, Anthony D.; Simon, Melinda G.; Davis, Cristina E.

    2009-01-01

    Sensors have been widely used for disease diagnosis, environmental quality monitoring, food quality control, industrial process analysis and control, and other related fields. As a key tool for sensor data analysis, machine learning is becoming a core part of novel sensor design. Dividing a complete machine learning process into three steps: data pre-treatment, feature extraction and dimension reduction, and system modeling, this paper provides a review of the methods that are widely used for each step. For each method, the principles and the key issues that affect modeling results are discussed. After reviewing the potential problems in machine learning processes, this paper gives a summary of current algorithms in this field and provides some feasible directions for future studies. PMID:20191110

  14. Blended near-optimal alternative generation, visualization, and interaction for water resources decision making

    NASA Astrophysics Data System (ADS)

    Rosenberg, David E.

    2015-04-01

    State-of-the-art systems analysis techniques focus on efficiently finding optimal solutions. Yet an optimal solution is optimal only for the modeled issues and managers often seek near-optimal alternatives that address unmodeled objectives, preferences, limits, uncertainties, and other issues. Early on, Modeling to Generate Alternatives (MGA) formalized near-optimal as performance within a tolerable deviation from the optimal objective function value and identified a few maximally different alternatives that addressed some unmodeled issues. This paper presents new stratified, Monte-Carlo Markov Chain sampling and parallel coordinate plotting tools that generate and communicate the structure and extent of the near-optimal region to an optimization problem. Interactive plot controls allow users to explore region features of most interest. Controls also streamline the process to elicit unmodeled issues and update the model formulation in response to elicited issues. Use for an example, single-objective, linear water quality management problem at Echo Reservoir, Utah, identifies numerous and flexible practices to reduce the phosphorus load to the reservoir and maintain close-to-optimal performance. Flexibility is upheld by further interactive alternative generation, transforming the formulation into a multiobjective problem, and relaxing the tolerance parameter to expand the near-optimal region. Compared to MGA, the new blended tools generate more numerous alternatives faster, more fully show the near-optimal region, and help elicit a larger set of unmodeled issues.

  15. A QRM Discussion of Microbial Contamination of Non-sterile Drug Products, Using FDA and EMA Warning Letters Recorded between 2008 and 2016.

    PubMed

    Santos, Ana M C; Doria, Mara S; Meirinhos-Soares, Luís; Almeida, António J; Menezes, José C

    2018-01-01

    Microbial quality control of non-sterile drug products has been a concern to regulatory agencies and the pharmaceutical industry since the 1960s. Despite being an old challenge to companies, microbial contamination still affects a high number of manufacturers of non-sterile products. Consequences go well beyond the obvious direct costs related to batch rejections or product recalls, as human lives and a company's reputation are significantly impacted if such events occur. To better manage risk and establish effective mitigation strategies, it is necessary to understand the microbial hazards involved in non-sterile drug products manufacturing, be able to evaluate their potential impact on final product quality, and apply mitigation actions. Herein we discuss the most likely root causes involved in microbial contaminations referenced in warning letters issued by US health authorities and non-compliance reports issued by European health authorities over a period of several years. The quality risk management tools proposed were applied to the data gathered from those databases, and a generic risk ranking was provided based on a panel of non-sterile drug product manufacturers that was assembled and given the opportunity to perform the risk assessments. That panel identified gaps and defined potential mitigation actions, based on their own experience of potential risks expected for their processes. Major findings clearly indicate that the manufacturers affected by the warning letters should focus their attention on process improvements and microbial control strategies, especially those related to microbial analysis and raw material quality control. Additionally, the WLs considered frequently referred to failures in quality-related issues, which indicates that the quality commitment should be reinforced at most companies to avoid microbiological contaminations. LAY ABSTRACT: Microbial contamination of drug products affects the quality of non-sterile drug products produced by numerous manufacturers, representing a major risk to patients. It is necessary to understand the microbial hazards involved in the manufacturing process and evaluate their impact on final product quality so that effective prevention strategies can be implemented. A risk-based classification of most likely root causes for microbial contamination found in the warning letters issued by the US Food and Drug Administration and the European Medicines Agency is proposed. To validate the likely root causes extracted from the warning letters, a subject matter expert panel made of several manufacturers was formed and consulted. A quality risk management approach to assess microbiological contamination of non-sterile drug products is proposed for the identification of microbial hazards involved in the manufacturing process. To enable ranking of microbial contamination risks, quality risk management metrics related to criticality and overall risk were applied. The results showed that manufacturers of non-sterile drug products should improve their microbial control strategy, with special attention to quality controls of raw materials, primary containers, and closures. Besides that, they should invest in a more robust quality system and culture. As a start, manufacturers may consider investigating their specific microbiological risks, adressing their sites' own microbial ecology, type of manufacturing processes, and dosage form characteristics, as these may lead to increased contamination risks. Authorities should allow and enforce innovative, more comprehensive, and more effective approaches to in-process contamination monitoring and controls. © PDA, Inc. 2018.

  16. Fuel processing for PEM fuel cells: transport and kinetic issues of system design

    NASA Astrophysics Data System (ADS)

    Zalc, J. M.; Löffler, D. G.

    In light of the distribution and storage issues associated with hydrogen, efficient on-board fuel processing will be a significant factor in the implementation of PEM fuel cells for automotive applications. Here, we apply basic chemical engineering principles to gain insight into the factors that limit performance in each component of a fuel processor. A system consisting of a plate reactor steam reformer, water-gas shift unit, and preferential oxidation reactor is used as a case study. It is found that for a steam reformer based on catalyst-coated foils, mass transfer from the bulk gas to the catalyst surface is the limiting process. The water-gas shift reactor is expected to be the largest component of the fuel processor and is limited by intrinsic catalyst activity, while a successful preferential oxidation unit depends on strict temperature control in order to minimize parasitic hydrogen oxidation. This stepwise approach of sequentially eliminating rate-limiting processes can be used to identify possible means of performance enhancement in a broad range of applications.

  17. The role of evidence-based media advocacy in the promotion of tobacco control policies.

    PubMed

    Lane, Ch'uyasonqo H; Carter, Marina I

    2012-06-01

    This article discusses the role of evidence-based media advocacy in the promotion of tobacco control policies. Evidence is a driving force for campaigns seeking to implement a tobacco control policy. An effective campaign is based in evidence that demonstrates why a policy should be implemented, and what the potential benefits are. Media advocacy is the process of disseminating information through the communications media where the aim is to effect action, such as a change of policy, or to alter the public's view of an issue. Discussion focuses on: 1) the importance of, and methods for, collecting and communicating evidence and information to make it clear and usable for legislators, the media, and the public; and 2) the role of earned and paid media in advancing tobacco control issues. The discussion is made within the context of a specific advocacy example; in this case the 2010 campaign to increase the tobacco tax in Mexico.

  18. Attention to Action: Willed and Automatic Control of Behavior.

    DTIC Science & Technology

    1980-12-15

    component is in need of supervisory assistance, has been suggested by LaBerge (1975), LaBerge and Samuels (1974); and Klein (1976). It is related to...Ed.), Motor Con- trol: Issues and Trends, New York: Academic Press, 1976. LaBerge , D., & Samuels, S.J. Toward a theory of automatic information...processing in reading. Cognitive Psychology 1974, 6, 293-323. LaBerge , D. Acquisition of automatic processing in perceptual and associative learning. In

  19. Integrated optics technology study

    NASA Technical Reports Server (NTRS)

    Chen, B.; Findakly, T.; Innarella, R.

    1982-01-01

    The status and near term potential of materials and processes available for the fabrication of single mode integrated electro-optical components are discussed. Issues discussed are host material and orientation, waveguide formation, optical loss mechanisms, wavelength selection, polarization effects and control, laser to integrated optics coupling fiber optic waveguides to integrated optics coupling, sources, and detectors. Recommendations of the best materials, technology, and processes for fabrication of integrated optical components for communications and fiber gyro applications are given.

  20. SURVIAC Bulletin: Materials Flammability in Spacecraft, Volume 25 - Issue 1

    DTIC Science & Technology

    2009-01-01

    and debris exiting the barrel of handguns is shown in the following example. Th is demonstrates the speed of the image processing algorithms to...gravity. Additionally, materials do not burn the same way. For example, when a candle burns on Earth, the hot gases from the fl ame rise, creating...cal. Th e controlling mechanisms of the combustion process change so that fi re prevention and material fl ammability considerations also change

  1. LANL Safeguards and Security Assurance Program. Revision 6

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1995-04-03

    The Safeguards and Security (S and S) Assurance Program provides a continuous quality improvement approach to ensure effective, compliant S and S program implementation throughout the Los Alamos National Laboratory. Any issues identified through the various internal and external assessments are documented, tracked and closed using the Safeguards and Security Issue Management Program. The Laboratory utilizes an integrated S and S systems approach to protect US Department of Energy (DOE) interests from theft or diversion of special nuclear material (SNM), sabotage, espionage, loss or theft of classified/controlled matter or government property, and other hostile acts that may cause unacceptable impactsmore » on national security, health and safety of employees and the public, and the environment. This document explains the basis, scope, and conduct of the S and S process to include: self-assessments, issue management, risk assessment, and root cause analysis. It also provides a discussion of S and S topical areas, roles and responsibilities, process flow charts, minimum requirements, methodology, terms, and forms.« less

  2. Laboratory Tests on Post-Filtration Precipitation in the WTP Pretreatment Process

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Russell, Renee L.; Peterson, Reid A.; Rinehart, Donald E.

    Pacific Northwest National Laboratory (PNNL) has been tasked by Bechtel National Inc. (BNI) on the River Protection Project-Hanford Tank Waste Treatment and Immobilization Plant (RPP-WTP) project to perform research and development activities to resolve technical issues identified for the Pretreatment Facility (PTF). The Pretreatment Engineering Platform (PEP) was designed, constructed, and operated as part of a plan to respond to issue M12, "Undemonstrated Leaching Processes," of the External Flowsheet Review Team (EFRT) issue response plan (Barnes et al. 2006). The PEP is a 1/4.5-scale test platform designed to simulate the WTP pretreatment caustic leaching, oxidative leaching, ultrafiltration solids concentration, andmore » slurry washing processes. The PEP replicates the WTP leaching processes using prototypic equipment and control strategies. A simplified flow diagram of the PEP system is shown in Figure 1.1. Two operating scenarios are currently being evaluated for the ultrafiltration process (UFP) and leaching operations. The first scenario has caustic leaching performed in the UFP-2 ultrafiltration feed vessels (i.e., vessel UFP-VSL-T02A in the PEP; and vessels UFP-VSL-00002A and B in the WTP PTF). The second scenario has caustic leaching conducted in the UFP-1 ultrafiltration feed preparation vessels (i.e., vessels UFP-VSL-T01A and B in the PEP; vessels UFP-VSL-00001A and B in the WTP PTF).« less

  3. The Role of Hybrid Make-to-Stock (MTS) - Make-to-Order (MTO) and Economic Order Quantity (EOQ) Inventory Control Models in Food and Beverage Processing Industry

    NASA Astrophysics Data System (ADS)

    Najhan Mohd Nagib, Ahmad; Naufal Adnan, Ahmad; Ismail, Azianti; Halim, Nurul Hayati Abdul; Syuhadah Khusaini, Nurul

    2016-11-01

    The inventory model had been utilized since the early 1900s. The implementation of the inventory management model is generally to ensure that an organisation is able to fulfil customer's demand at the lowest possible cost to improve profitability. This paper focuses on reviewing previous published papers regarding inventory control model mainly in the food and beverage processing industry. The author discusses four inventory models, which are the make-to-stock (MTS), make-to-order (MTO), economic order quantity (EOQ), and hybrid of MTS-MTO models. The issues raised by the researchers on the above techniques as well as the elements need to be considered upon selection have been discussed in this paper. The main objective of the study is to highlight the important role played by these inventory control models in the food and beverage processing industry.

  4. Quality assurance and control issues for HF radar wave and current measurements

    NASA Astrophysics Data System (ADS)

    Wyatt, Lucy

    2015-04-01

    HF radars are now widely used to provide surface current measurements over wide areas of the coastal ocean for scientific and operational applications. In general data quality is acceptable for these applications but there remain issues that impact on the quantity and quality of the data. These include problems with calibration and interference which impact on both phased array (e.g. WERA, Pisces) and direction-finding (e.g. SeaSonde) radars. These same issues and others (e.g. signal-to-noise, in-cell current variability, antenna sidelobes) also impact on the quality and quantity of wave data that can be obtained. These issues will be discussed in this paper, illustrated with examples from deployments of WERA, Pisces and SeaSonde radars in the UK, Europe, USA and Australia. These issues involve both quality assurance (making sure the radars perform to spec and the software is fully operational) and in quality control (identifying problems with the data due to radar hardware or software performance issues and flagging these in the provided data streams). Recommendations for the former, and current practice (of the author and within the Australian Coastal Ocean Radar Network, ACORN*) for the latter, will be discussed. The quality control processes for wave measurement are not yet as well developed as those for currents and data from some deployments can be rather noisy. Some new methods, currently under development by SeaView Sensing Ltd and being tested with ACORN data, will be described and results presented. *ACORN is a facility of the Australian Integrated Marine Observing System, IMOS. IMOS is a national collaborative research infrastructure, supported by Australian Government. It is led by University of Tasmania in partnership with the Australian marine and climate science community.

  5. Considerations for pattern placement error correction toward 5nm node

    NASA Astrophysics Data System (ADS)

    Yaegashi, Hidetami; Oyama, Kenichi; Hara, Arisa; Natori, Sakurako; Yamauchi, Shohei; Yamato, Masatoshi; Koike, Kyohei; Maslow, Mark John; Timoshkov, Vadim; Kiers, Ton; Di Lorenzo, Paolo; Fonseca, Carlos

    2017-03-01

    Multi-patterning has been adopted widely in high volume manufacturing as 193 immersion extension, and it becomes realistic solution of nano-order scaling. In fact, it must be key technology on single directional (1D) layout design [1] for logic devise and it becomes a major option for further scaling technique in SAQP. The requirement for patterning fidelity control is getting savior more and more, stochastic fluctuation as well as LER (Line edge roughness) has to be micro-scopic observation aria. In our previous work, such atomic order controllability was viable in complemented technique with etching and deposition [2]. Overlay issue form major potion in yield management, therefore, entire solution is needed keenly including alignment accuracy on scanner and detectability on overlay measurement instruments. As EPE (Edge placement error) was defined as the gap between design pattern and contouring of actual pattern edge, pattern registration in single process level must be considerable. The complementary patterning to fabricate 1D layout actually mitigates any process restrictions, however, multiple process step, symbolized as LELE with 193-i, is burden to yield management and affordability. Recent progress of EUV technology is remarkable, and it is major potential solution for such complicated technical issues. EUV has robust resolution limit and it must be definitely strong scaling driver for process simplification. On the other hand, its stochastic variation such like shot noise due to light source power must be resolved with any additional complemented technique. In this work, we examined the nano-order CD and profile control on EUV resist pattern and would introduce excellent accomplishments.

  6. Information Security Management (ISM)

    NASA Astrophysics Data System (ADS)

    Šalgovičová, Jarmila; Prajová, Vanessa

    2012-12-01

    Currently, all organizations have to tackle the issue of information security. The paper deals with various aspects of Information Security Management (ISM), including procedures, processes, organizational structures, policies and control processes. Introduction of Information Security Management should be a strategic decision. The concept and implementation of Information Security Management in an organization are determined by the corporate needs and objectives, security requirements, the processes deployed as well as the size and structure of the organization. The implementation of ISM should be carried out to the extent consistent with the needs of the organization.

  7. An Architecture for SCADA Network Forensics

    NASA Astrophysics Data System (ADS)

    Kilpatrick, Tim; Gonzalez, Jesus; Chandia, Rodrigo; Papa, Mauricio; Shenoi, Sujeet

    Supervisory control and data acquisition (SCADA) systems are widely used in industrial control and automation. Modern SCADA protocols often employ TCP/IP to transport sensor data and control signals. Meanwhile, corporate IT infrastructures are interconnecting with previously isolated SCADA networks. The use of TCP/IP as a carrier protocol and the interconnection of IT and SCADA networks raise serious security issues. This paper describes an architecture for SCADA network forensics. In addition to supporting forensic investigations of SCADA network incidents, the architecture incorporates mechanisms for monitoring process behavior, analyzing trends and optimizing plant performance.

  8. Panel summary of recommendations

    NASA Technical Reports Server (NTRS)

    Dunbar, Bonnie J.; Coleman, Martin E.; Mitchell, Kenneth L.

    1990-01-01

    The following Space Station internal contamination topics were addressed: past flight experience (Skylab and Spacelab missions); present flight activities (Spacelabs and Soviet Space Station Mir); future activities (materials science and life science experiments); Space Station capabilities (PPMS, FMS, ECLSS, and U.S. Laboratory overview); manned systems/crew safety; internal contamination detection; contamination control - stowage and handling; and contamination control - waste gas processing. Space Station design assumptions are discussed. Issues and concerns are discussed as they relate to (1) policy and management, (2) subsystem design, (3) experiment design, and (4) internal contamination detection and control. The recommendations generated are summarized.

  9. Issues Management Process Course # 38401

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Binion, Ula Marie

    The purpose of this training it to advise Issues Management Coordinators (IMCs) on the revised Contractor Assurance System (CAS) Issues Management (IM) process. Terminal Objectives: Understand the Laboratory’s IM process; Understand your role in the Laboratory’s IM process. Learning Objectives: Describe the IM process within the context of the CAS; Describe the importance of implementing an institutional IM process at LANL; Describe the process flow for the Laboratory’s IM process; Apply the definition of an issue; Use available resources to determine initial screening risk levels for issues; Describe the required major process steps for each risk level; Describe the personnelmore » responsibilities for IM process implementation; Access available resources to support IM process implementation.« less

  10. Optimizing the way kinematical feed chains with great distance between slides are chosen for CNC machine tools

    NASA Astrophysics Data System (ADS)

    Lucian, P.; Gheorghe, S.

    2017-08-01

    This paper presents a new method, based on FRISCO formula, for optimizing the choice of the best control system for kinematical feed chains with great distance between slides used in computer numerical controlled machine tools. Such machines are usually, but not limited to, used for machining large and complex parts (mostly in the aviation industry) or complex casting molds. For such machine tools the kinematic feed chains are arranged in a dual-parallel drive structure that allows the mobile element to be moved by the two kinematical branches and their related control systems. Such an arrangement allows for high speed and high rigidity (a critical requirement for precision machining) during the machining process. A significant issue for such an arrangement it’s the ability of the two parallel control systems to follow the same trajectory accurately in order to address this issue it is necessary to achieve synchronous motion control for the two kinematical branches ensuring that the correct perpendicular position it’s kept by the mobile element during its motion on the two slides.

  11. Dendritic cells for active immunotherapy: optimizing design and manufacture in order to develop commercially and clinically viable products.

    PubMed

    Nicolette, C A; Healey, D; Tcherepanova, I; Whelton, P; Monesmith, T; Coombs, L; Finke, L H; Whiteside, T; Miesowicz, F

    2007-09-27

    Dendritic cell (DC) active immunotherapy is potentially efficacious in a broad array of malignant disease settings. However, challenges remain in optimizing DC-based therapy for maximum clinical efficacy within manufacturing processes that permit quality control and scale-up of consistent products. In this review we discuss the critical issues that must be addressed in order to optimize DC-based product design and manufacture, and highlight the DC based platforms currently addressing these issues. Variables in DC-based product design include the type of antigenic payload used, DC maturation steps and activation processes, and functional assays. Issues to consider in development include: (a) minimizing the invasiveness of patient biological material collection; (b) minimizing handling and manipulations of tissue at the clinical site; (c) centralized product manufacturing and standardized processing and capacity for commercial-scale production; (d) rapid product release turnaround time; (e) the ability to manufacture sufficient product from limited starting material; and (f) standardized release criteria for DC phenotype and function. Improvements in the design and manufacture of DC products have resulted in a handful of promising leads currently in clinical development.

  12. Controlled ice nucleation in the field of freeze-drying: fundamentals and technology review.

    PubMed

    Geidobler, R; Winter, G

    2013-10-01

    In the scientific community as well as in commercial freeze-drying, controlled ice nucleation has received a lot of attention because increasing the ice nucleation temperature can significantly reduce primary drying duration. Furthermore, controlled ice nucleation enables to reduce the randomness of the ice nucleation temperature, which can be a serious scale-up issue during process development. In this review, fundamentals of ice nucleation in the field of freeze-drying are presented. Furthermore, the impact of controlled ice nucleation on product qualities is discussed, and methods to achieve controlled ice nucleation are presented. Copyright © 2013 Elsevier B.V. All rights reserved.

  13. A survey on the design of multiprocessing systems for artificial intelligence applications

    NASA Technical Reports Server (NTRS)

    Wah, Benjamin W.; Li, Guo Jie

    1989-01-01

    Some issues in designing computers for artificial intelligence (AI) processing are discussed. These issues are divided into three levels: the representation level, the control level, and the processor level. The representation level deals with the knowledge and methods used to solve the problem and the means to represent it. The control level is concerned with the detection of dependencies and parallelism in the algorithmic and program representations of the problem, and with the synchronization and sheduling of concurrent tasks. The processor level addresses the hardware and architectural components needed to evaluate the algorithmic and program representations. Solutions for the problems of each level are illustrated by a number of representative systems. Design decisions in existing projects on AI computers are classed into top-down, bottom-up, and middle-out approaches.

  14. Metrologies for quantitative nanomechanical testing and quality control in semiconductor manufacturing

    NASA Astrophysics Data System (ADS)

    Pratt, Jon R.; Kramar, John A.; Newell, David B.; Smith, Douglas T.

    2005-05-01

    If nanomechanical testing is to evolve into a tool for process and quality control in semiconductor fabrication, great advances in throughput, repeatability, and accuracy of the associated instruments and measurements will be required. A recent grant awarded by the NIST Advanced Technology Program seeks to address the throughput issue by developing a high-speed AFM-based platform for quantitative nanomechanical measurements. The following paper speaks to the issue of quantitative accuracy by presenting an overview of various standards and techniques under development at NIST and other national metrology institutes (NMIs) that can provide a metrological basis for nanomechanical testing. The infrastructure we describe places firm emphasis on traceability to the International System of Units, paving the way for truly quantitative, rather than qualitative, physical property testing.

  15. Explicit analytical tuning rules for digital PID controllers via the magnitude optimum criterion.

    PubMed

    Papadopoulos, Konstantinos G; Yadav, Praveen K; Margaris, Nikolaos I

    2017-09-01

    Analytical tuning rules for digital PID type-I controllers are presented regardless of the process complexity. This explicit solution allows control engineers 1) to make an accurate examination of the effect of the controller's sampling time to the control loop's performance both in the time and frequency domain 2) to decide when the control has to be I, PI and when the derivative, D, term has to be added or omitted 3) apply this control action to a series of stable benchmark processes regardless of their complexity. The former advantages are considered critical in industry applications, since 1) most of the times the choice of the digital controller's sampling time is based on heuristics and past criteria, 2) there is little a-priori knowledge of the controlled process making the choice of the type of the controller a trial and error exercise 3) model parameters change often depending on the control loop's operating point making in this way, the problem of retuning the controller's parameter a much challenging issue. Basis of the proposed control law is the principle of the PID tuning via the Magnitude Optimum criterion. The final control law involves the controller's sampling time T s within the explicit solution of the controller's parameters. Finally, the potential of the proposed method is justified by comparing its performance with the conventional PID tuning when controlling the same process. Further investigation regarding the choice of the controller's sampling time T s is also presented and useful conclusions for control engineers are derived. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.

  16. Redox Control For Hanford HLW Feeds VSL-12R2530-1, REV 0

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kruger, A. A.; Matlack, Keith S.; Pegg, Ian L.

    2012-12-13

    The principal objectives of this work were to investigate the effects of processing simulated Hanford HLW at the estimated maximum concentrations of nitrates and oxalates and to identify strategies to mitigate any processing issues resulting from high concentrations of nitrates and oxalates. This report provides results for a series of tests that were performed on the DM10 melter system with simulated C-106/AY-102 HLW. The tests employed simulated HLW feeds containing variable amounts of nitrates and waste organic compounds corresponding to maximum concentrations proj ected for Hanford HLW streams in order to determine their effects on glass production rate, processing characteristics,more » glass redox conditions, melt pool foaming, and the tendency to form secondary phases. Such melter tests provide information on key process factors such as feed processing behavior, dynamic effects during processing, processing rates, off-gas amounts and compositions, foaming control, etc., that cannot be reliably obtained from crucible melts.« less

  17. Technology for On-Chip Qubit Control with Microfabricated Surface Ion Traps

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Highstrete, Clark; Scott, Sean Michael; Nordquist, Christopher D.

    2013-11-01

    Trapped atomic ions are a leading physical system for quantum information processing. However, scalability and operational fidelity remain limiting technical issues often associated with optical qubit control. One promising approach is to develop on-chip microwave electronic control of ion qubits based on the atomic hyperfine interaction. This project developed expertise and capabilities at Sandia toward on-chip electronic qubit control in a scalable architecture. The project developed a foundation of laboratory capabilities, including trapping the 171Yb + hyperfine ion qubit and developing an experimental microwave coherent control capability. Additionally, the project investigated the integration of microwave device elements with surface ionmore » traps utilizing Sandia’s state-of-the-art MEMS microfabrication processing. This effort culminated in a device design for a multi-purpose ion trap experimental platform for investigating on-chip microwave qubit control, laying the groundwork for further funded R&D to develop on-chip microwave qubit control in an architecture that is suitable to engineering development.« less

  18. [Construction of NIRS-based process analytical system for production of salvianolic acid for injection and relative discussion].

    PubMed

    Zhang, Lei; Yue, Hong-Shui; Ju, Ai-Chun; Ye, Zheng-Liang

    2016-10-01

    Currently, near infrared spectroscopy (NIRS) has been considered as an efficient tool for achieving process analytical technology(PAT) in the manufacture of traditional Chinese medicine (TCM) products. In this article, the NIRS based process analytical system for the production of salvianolic acid for injection was introduced. The design of the process analytical system was described in detail, including the selection of monitored processes and testing mode, and potential risks that should be avoided. Moreover, the development of relative technologies was also presented, which contained the establishment of the monitoring methods for the elution of polyamide resin and macroporous resin chromatography processes, as well as the rapid analysis method for finished products. Based on author's experience of research and work, several issues in the application of NIRS to the process monitoring and control in TCM production were then raised, and some potential solutions were also discussed. The issues include building the technical team for process analytical system, the design of the process analytical system in the manufacture of TCM products, standardization of the NIRS-based analytical methods, and improving the management of process analytical system. Finally, the prospect for the application of NIRS in the TCM industry was put forward. Copyright© by the Chinese Pharmaceutical Association.

  19. Design Considerations For A Clinical XeC1 Excimer Laser Angioplasty System

    NASA Astrophysics Data System (ADS)

    Laudenslager, James B.; Goldenberg, Tsvi; Naghieh, Harry R.; Pham, Andrew A.; Narciso, Hugh L.; Tranis, Art; Pacala, Thomas J.

    1989-09-01

    Laser ablation and removal of intravascular plaque has long been a goal of physicians and physicists as an alternative treatment for coronary and peripheral artery disease. Early application of cw free light beam visible and infrared lasers such as argon ion or Nd:YAG lasers for this application were plagued by thermal side effects of the ablation process. Specifically, imprecise control of the boundary tissue injury produced by the deep penetration depth of the laser beam gave rise to early reclosure of the vessel due to the thermal nature of the ablation process. Pulsed ultraviolet laser free beam ablation of atherosclerotic plaque, however, does not produce thermal effects, cuts tissue precisely leaving a smooth wall and can ablate hard calcific lesions. We have chosen to develop a XeC1 excimer laser-fiberoptic delivery system for the clinical application of laser angioplasty based on achieving the desired therapeutic results for a laser revascularization procedure. Four major engineering design issues must be considered in order to produce a successful clinical laser angioplasty product. These engineering issues are: 1) Functional clinical engineering, 2) Regulatory design issues, 3) Hospital facility and user requirements, and 4) Economic issues for the manufacturer, the hospital and the patient.

  20. Application of Concurrent Engineering Methods to the Design of an Autonomous Aerial Robot

    DTIC Science & Technology

    1991-12-01

    power within the system, either airborne or at a ground station, was left to the team’s discretion. Data link from the aerial vehicle to the ground...Design Process 1 4 10 0% Conceptual 100% Preliminary 100% Detailed 100% Design Freedom Kowledge About the Design TIME INTO THE DESIGN PROCESS Figure 15...mission planning and control tasks was accomplished. Key system issues regarding power up and component initialization procedures began to be addressed

  1. Integrated optics technology study

    NASA Technical Reports Server (NTRS)

    Chen, B.

    1982-01-01

    The materials and processes available for the fabrication of single mode integrated electrooptical components are described. Issues included in the study are: (1) host material and orientation, (2) waveguide formation, (3) optical loss mechanisms, (4) wavelength selection, (5) polarization effects and control, (6) laser to integrated optics coupling,(7) fiber optic waveguides to integrated optics coupling, (8) souces, (9) detectors. The best materials, technology and processes for fabrication of integrated optical components for communications and fiber gyro applications are recommended.

  2. Review of Findings for Human Performance Contribution to Risk in Operating Events

    DTIC Science & Technology

    2002-03-01

    and loss of DC power. Key to this event was failure to control setpoints on safety-related equipment and failure to maintain the load tap changer...34 Therefore, "to optimize task execution at the job site, it is important to align organizational processes and values." Effective team skills are an...reactor was blocked and the water level rapidly dropped to the automatic low-level scram setpoint . Human Performance Issues Control rods were fully

  3. A Structural Characterization of Temporal Dynamic Controllability

    NASA Technical Reports Server (NTRS)

    Morris, Paul

    2006-01-01

    An important issue for temporal planners is the ability to handle temporal uncertainty. Recent papers have addressed the question of how to tell whether a temporal network is Dynamically Controllable, i.e., whether the temporal requirements are feasible in the light of uncertain durations of some processes. Previous work has presented an O(N5) algorithm for testing this property. Here, we introduce a new analysis of temporal cycles that leads to an O(N4) algorithm.

  4. Relationships among Repetitive Behaviors, Sensory Features, and Executive Functions in High Functioning Autism

    ERIC Educational Resources Information Center

    Boyd, Brian A.; McBee, Matthew; Holtzclaw, Tia; Baranek, Grace T.; Bodfish, James W.

    2009-01-01

    This study examined the relationship between repetitive behaviors and sensory processing issues in school-aged children with high functioning autism (HFA). Children with HFA (N = 61) were compared to healthy, typical controls (N = 64) to determine the relationship between these behavioral classes and to examine whether executive dysfunction…

  5. Reflections on Doing Inclusive Research in the "Making Life Good in the Community" Study

    ERIC Educational Resources Information Center

    Bigby, Christine; Frawley, Patsie

    2010-01-01

    Background: The involvement of people with intellectual disability in research is framed as inclusive, denoting their active participation in its processes. However, questions are raised about ownership and control, genuineness of involvement, and the need for honest accounts to develop practice. Such issues are particularly pressing in Australia,…

  6. 77 FR 24698 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-25

    ... Environmental Protection Agency (EPA) to support the decision making process for an industrial chemical under the Toxic Substances Control Act (TSCA) (15 U.S.C. 2601). Under TSCA, EPA has the authority to issue... exposure to chemical substances and mixtures. Drugs, cosmetics, foods, food additives, pesticides, and...

  7. THE US POSITION AND FATE OF PATHOGENS IN SEWAGE SLUDGE AND THE US 40CFR503 REGULATION

    EPA Science Inventory

    This paper reviews the pathogenic microorganisms that may be found in sewage sludge and the commonly employed Class A and B treatment processes for controlling pathogens. It notes how extensively they are used and discusses issues and concerns with them. Preliminary findings of a...

  8. Politic of Security, Privacy and Transparency in Human Learning Systems

    ERIC Educational Resources Information Center

    Jeghal, Adil; Oughdir, Lahcen; Tairi, Hamid

    2016-01-01

    The preservation of confidentiality has become a major issue for the majority of applications that process personal information, the sensitivity of this information requires creators to set rules for the sharing and use of access control policies. A great deal of research has already been conducted in educational environments. However, one aspect…

  9. Psychiatry and psychotherapy as political processes.

    PubMed

    Breggin, P R

    1975-07-01

    Therapy is applied politics. From hospitalizing a patient to offering psychoanalytic insight, a therapist's every action reflects his own attitudes toward political issues, including individual freedom vs. state control, or capitalism versus socialism. Ultimately every therapy implements some utopian political vision against which the client will measure his own success and failure in the therapy.

  10. The Fail-Safe Micro Research Paper.

    ERIC Educational Resources Information Center

    Saunders, Mary Anne

    A key element in a research paper writing assignment modified for students of English as a second language to assure their success is teacher control over most of the process. A chronological plan for action for the micro research project includes these steps: creating an awareness of current events and controversial issues, practicing necessary…

  11. Electrophysiological Evidence of Atypical Motivation and Reward Processing in Children with Attention-Deficit Hyperactivity Disorder

    ERIC Educational Resources Information Center

    Holroyd, Clay B.; Baker, Travis E.; Kerns, Kimberly A.; Muller, Ulrich

    2008-01-01

    Behavioral and neurophysiological evidence suggest that attention-deficit hyperactivity disorder (ADHD) is characterized by the impact of abnormal reward prediction error signals carried by the midbrain dopamine system on frontal brain areas that implement cognitive control. To investigate this issue, we recorded the event-related brain potential…

  12. Advanced Vehicle Control Systems (Avcs) For Maintenance Vehicle Applications, Contract No. Dtfh61-94-C-00131, Work Order 11, Prepared For: Department Of Transportation

    DOT National Transportation Integrated Search

    1996-12-20

    IT IS WIDELY BELIEVED THAT BARRIERS TO AN AUTOMATED HIGHWAY SYSTEM (AHS) : DEPLOYMENT ARE DUE MORE TO INSTITUTIONAL, ECONOMIC, AND LEGAL ISSUES THAN TECHNOLOGY LIMITATIONS. IN ORDER TO SUSTAIN AND ACCELERATE THE AHS DEPLOYMENT PROCESS, IT IS DESIRABL...

  13. Beyond Socioeconomics: Explaining Ethnic Group Differences in Parenting through Cultural and Immigration Processes

    ERIC Educational Resources Information Center

    Chao, Ruth; Kanatsu, Akira

    2008-01-01

    This study examined both socioeconomic and cultural factors in explaining ethnic differences in monitoring, behavioral control, and warmth--part of a series of coordinated studies presented in this special issue. Socioeconomic variables included mother's and father's educational levels, employment status, home ownership, number of siblings in the…

  14. Middle Atmosphere Program. Handbook for MAP. Volume 30: International School on Atmospheric Radar

    NASA Technical Reports Server (NTRS)

    Fukao, Shoichiro (Editor)

    1989-01-01

    Broad, tutorial coverage is given to the technical and scientific aspects of mesosphere stratosphere troposphere (MST) meteorological radar systems. Control issues, signal processing, atmospheric waves, the historical aspects of radar atmospheric dynamics, incoherent scatter radars, radar echoes, radar targets, and gravity waves are among the topics covered.

  15. Good manufacturing practice and viral safety.

    PubMed

    Kerner, B

    1995-07-01

    The concept of virus inactivation during the manufacture of blood products raises questions about possible recontamination of the product by the environment. A strict regime of good manufacturing practice (GMP) is mandatory. The guidelines originally issued by the World Health Organization (WHO), and now law in most countries, are an excellent basis for the operation of a production plant. The following elements of GMP require special concern: (i) All functions shall be defined in a clear organization chart. (ii) Personnel shall be appropriately trained for the job and to perfect hygiene. (iii) Buildings and facilities, as well as supply systems, shall exclude the possibility of recontamination of already virus-inactivated materials. (iv) Equipment shall be easy to clean and fully sterilizable. (v) Production shall follow appropriate written procedures. (vi) The Quality Control Organization shall monitor the process by in-process controls and review the records for possible deviations. All GMP issues are coordinated by a Quality Assurance Organization that also reviews the overall performance of the operation. The maintenance of viral safety of the products basically depends upon the full commitment of all bodies involved to proper and non-negotiable GMP.

  16. Novel approaches to improving the chemical safety of the meat chain towards toxicants.

    PubMed

    Engel, E; Ratel, J; Bouhlel, J; Planche, C; Meurillon, M

    2015-11-01

    In addition to microbiological issues, meat chemical safety is a growing concern for the public authorities, chain stakeholders and consumers. Meat may be contaminated by various chemical toxicants originating from the environment, treatments of agricultural production or food processing. Generally found at trace levels in meat, these toxicants may harm human health during chronic exposure. This paper overviews the key issues to be considered to ensure better control of their occurrence in meat and assessment of the related health risk. We first describe potential contaminants of meat products. Strategies to move towards a more efficient and systematic control of meat chemical safety are then presented in a second part, with a focus on emerging approaches based on toxicogenomics. The third part presents mitigation strategies to limit the impact of process-induced toxicants in meat. Finally, the last part introduces methodological advances to refine chemical risk assessment related to the occurrence of toxicants in meat by quantifying the influence of digestion on the fraction of food contaminants that may be assimilated by the human body. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. Dynamic Control of Plans with Temporal Uncertainty

    NASA Technical Reports Server (NTRS)

    Morris, Paul; Muscettola, Nicola; Vidal, Thierry

    2001-01-01

    Certain planning systems that deal with quantitative time constraints have used an underlying Simple Temporal Problem solver to ensure temporal consistency of plans. However, many applications involve processes of uncertain duration whose timing cannot be controlled by the execution agent. These cases require more complex notions of temporal feasibility. In previous work, various "controllability" properties such as Weak, Strong, and Dynamic Controllability have been defined. The most interesting and useful Controllability property, the Dynamic one, has ironically proved to be the most difficult to analyze. In this paper, we resolve the complexity issue for Dynamic Controllability. Unexpectedly, the problem turns out to be tractable. We also show how to efficiently execute networks whose status has been verified.

  18. Laser-Material Interactions for Flexible Applications.

    PubMed

    Joe, Daniel J; Kim, Seungjun; Park, Jung Hwan; Park, Dae Yong; Lee, Han Eol; Im, Tae Hong; Choi, Insung; Ruoff, Rodney S; Lee, Keon Jae

    2017-07-01

    The use of lasers for industrial, scientific, and medical applications has received an enormous amount of attention due to the advantageous ability of precise parameter control for heat transfer. Laser-beam-induced photothermal heating and reactions can modify nanomaterials such as nanoparticles, nanowires, and two-dimensional materials including graphene, in a controlled manner. There have been numerous efforts to incorporate lasers into advanced electronic processing, especially for inorganic-based flexible electronics. In order to resolve temperature issues with plastic substrates, laser-material processing has been adopted for various applications in flexible electronics including energy devices, processors, displays, and other peripheral electronic components. Here, recent advances in laser-material interactions for inorganic-based flexible applications with regard to both materials and processes are presented. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. Use of radiation in the production of hydrogels

    NASA Astrophysics Data System (ADS)

    Lugao, Ademar B.; Malmonge, Sônia Maria

    2001-12-01

    The first hydrogel for wound dressing processed by radiation left the laboratories in Poland in 1986 by the hands of its inventor Janusz M. Rosiak and soon, after formal tests, arrived in the local market (1992). It was a technological breakthrough due to its product characteristics as pain reliever and enhanced healing properties besides its clever production process combining sterilization and crosslinking in a simultaneous operation. IAEA invited professor Rosiak to support the transference of his technology for many laboratories around the world. The laboratories of developing countries, which face all kinds of restrictions, were seduced by the simplicity of the process and low cost of its raw materials. This was the seed of the flourishing activities in hydrogel dressings in Brazil and other developing countries. The technology transfer of the radiation production of hydrogel dressings and other hydrogels to the Brazilian industry is under way. The usual issues associated with radiation processing arise from this experience, i.e. capital costs, misinformation about radiation and lack of expertise on radiation processing. Some other issues concerning local market and social peculiarities also add to the problem. Notwithstanding, many different opportunities arise from those challenges. These technical and commercial issues are roughly: (i) There are plenty of new hydrogels in the market and all say the same. What else radiation processed hydrogels can say? (ii) Regarding to hydrogels and its industrial production as market product, what are the unique characteristics of radiation processing? It was shown that the radiation is a powerful tool for producing hydrogels the same basic formula with improved flexibility, control and purity.

  20. Incorporating Handling Qualities Analysis into Rotorcraft Conceptual Design

    NASA Technical Reports Server (NTRS)

    Lawrence, Ben

    2014-01-01

    This paper describes the initial development of a framework to incorporate handling qualities analyses into a rotorcraft conceptual design process. In particular, the paper describes how rotorcraft conceptual design level data can be used to generate flight dynamics models for handling qualities analyses. Also, methods are described that couple a basic stability augmentation system to the rotorcraft flight dynamics model to extend analysis to beyond that of the bare airframe. A methodology for calculating the handling qualities characteristics of the flight dynamics models and for comparing the results to ADS-33E criteria is described. Preliminary results from the application of the handling qualities analysis for variations in key rotorcraft design parameters of main rotor radius, blade chord, hub stiffness and flap moment of inertia are shown. Varying relationships, with counteracting trends for different handling qualities criteria and different flight speeds are exhibited, with the action of the control system playing a complex part in the outcomes. Overall, the paper demonstrates how a broad array of technical issues across flight dynamics stability and control, simulation and modeling, control law design and handling qualities testing and evaluation had to be confronted to implement even a moderately comprehensive handling qualities analysis of relatively low fidelity models. A key outstanding issue is to how to 'close the loop' with an overall design process, and options for the exploration of how to feedback handling qualities results to a conceptual design process are proposed for future work.

  1. Entertainment-education and recruitment of cornea donors: the role of emotion and issue involvement.

    PubMed

    Bae, Hyuhn-Suhck

    2008-01-01

    This study examined the role of emotional responses and viewer's level of issue involvement to an entertainment-education show about cornea donation in order to predict intention to register as cornea donors. Results confirmed that sympathy and empathy responses operated as a catalyst for issue involvement, which emerged as an important intermediary in the persuasion process. Issue involvement also was found to be a common causal antecedent of attitude, subjective norm, and perceived behavioral control, the last two of which predict intentions unlike attitude, which does not. The revised path model confirmed that involvement directly influences intention. The findings of this study suggest that adding emotion and involvement in the Theory of Planned Behavior (TPB) enhances the explanatory power of the theory in predicting intentions, which indicates the possibility of combining the Elaboration Likelihood Model (ELM) and the TPB in the prediction of human behaviors.

  2. Neurolinguistically constrained simulation of sentence comprehension: integrating artificial intelligence and brain theory

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gigley, H.M.

    1982-01-01

    An artificial intelligence approach to the simulation of neurolinguistically constrained processes in sentence comprehension is developed using control strategies for simulation of cooperative computation in associative networks. The desirability of this control strategy in contrast to ATN and production system strategies is explained. A first pass implementation of HOPE, an artificial intelligence simulation model of sentence comprehension, constrained by studies of aphasic performance, psycholinguistics, neurolinguistics, and linguistic theory is described. Claims that the model could serve as a basis for sentence production simulation and for a model of language acquisition as associative learning are discussed. HOPE is a model thatmore » performs in a normal state and includes a lesion simulation facility. HOPE is also a research tool. Its modifiability and use as a tool to investigate hypothesized causes of degradation in comprehension performance by aphasic patients are described. Issues of using behavioral constraints in modelling and obtaining appropriate data for simulated process modelling are discussed. Finally, problems of validation of the simulation results are raised; and issues of how to interpret clinical results to define the evolution of the model are discussed. Conclusions with respect to the feasibility of artificial intelligence simulation process modelling are discussed based on the current state of research.« less

  3. Adaptive harvest management of North American waterfowl populations - recent successes and future prospects

    USGS Publications Warehouse

    Nichols, J.D.; Runge, M.C.; Johnson, F.A.; Williams, B.K.; Schodde, Richard; Hannon, Susan; Scheiffarth, Gregor; Bairlein, Franz

    2006-01-01

    The history of North American waterfowl harvest management has been characterized by attempts to use population monitoring data to make informed harvest management decisions. Early attempts can be characterized as intuitive decision processes, and later efforts were guided increasingly by population models and associated predictions. In 1995, a formal adaptive management process was implemented, and annual decisions about duck harvest regulations in the United States are still based on this process. This formal decision process is designed to deal appropriately with the various forms of uncertainty that characterize management decisions, environmental uncertainty, structural uncertainty, partial controllability and partial observability. The key components of the process are (1) objectives, (2) potential management actions, (3) model(s) of population response to management actions, (4) credibility measures for these models, and (5) a monitoring program. The operation of this iterative process is described, and a brief history of a decade of its use is presented. Future challenges range from social and political issues such as appropriate objectives and management actions, to technical issues such as multispecies management, geographic allocation of harvest, and incorporation of actions that include habitat acquisition and management.

  4. Computer modeling of dynamic necking in bars

    NASA Astrophysics Data System (ADS)

    Partom, Yehuda; Lindenfeld, Avishay

    2017-06-01

    Necking of thin bodies (bars, plates, shells) is one form of strain localization in ductile materials that may lead to fracture. The phenomenon of necking has been studied extensively, initially for quasistatic loading and then also for dynamic loading. Nevertheless, many issues concerning necking are still unclear. Among these are: 1) is necking a random or deterministic process; 2) how does the specimen choose the final neck location; 3) to what extent do perturbations (material or geometrical) influence the neck forming process; and 4) how do various parameters (material, geometrical, loading) influence the neck forming process. Here we address these issues and others using computer simulations with a hydrocode. Among other things we find that: 1) neck formation is a deterministic process, and by changing one of the parameters influencing it monotonously, the final neck location moves monotonously as well; 2) the final neck location is sensitive to the radial velocity of the end boundaries, and as motion of these boundaries is not fully controlled in tests, this may be the reason why neck formation is sometimes regarded as a random process; and 3) neck formation is insensitive to small perturbations, which is probably why it is a deterministic process.

  5. Issues Management and the Role of Strategic Planning. AIR 1985 Annual Forum Paper.

    ERIC Educational Resources Information Center

    Lozier, G. Gregory; Chittipeddi, Kumar

    The integration of issues management into the institutional strategic planning process at Pennsylvania State University is discussed. The significance of issues management as an organizational process is also considered. Stages of the issues management process are: (1) scanning the external environment to identify strategic issues; (2) analyzing…

  6. Localized structures in dissipative media: from optics to plant ecology

    PubMed Central

    Tlidi, M.; Staliunas, K.; Panajotov, K.; Vladimirov, A. G.; Clerc, M. G.

    2014-01-01

    Localized structures (LSs) in dissipative media appear in various fields of natural science such as biology, chemistry, plant ecology, optics and laser physics. The proposal for this Theme Issue was to gather specialists from various fields of nonlinear science towards a cross-fertilization among active areas of research. This is a cross-disciplinary area of research dominated by nonlinear optics due to potential applications for all-optical control of light, optical storage and information processing. This Theme Issue contains contributions from 18 active groups involved in the LS field and have all made significant contributions in recent years. PMID:25246688

  7. Usage of noncontact human body measurements for development of Army Work Wear Trousers

    NASA Astrophysics Data System (ADS)

    Dabolina, Inga; Lapkovska, Eva; Vilumsone, Ausma

    2017-10-01

    The paper is based on issues related to imperfections of clothing fit, garment construction solutions and control measurement systems of finished products, which were identified in the research process analysing army soldier work wear trousers. The aim is to obtain target group body measurements using noncontact anthropometrical data acquisition method (3D scanning) for selection and analysis of scanned data suitable for trouser design. Tasks include comparison of scanned data with manually taken body measurements and different corresponding human body measurement standard data for establishing potential advantages of noncontact method usage in solving different trouser design issues.

  8. Thermal Catalytic Oxidation of Airborne Contaminants by a Reactor Using Ultra-Short Channel Length, Monolithic Catalyst Substrates

    NASA Technical Reports Server (NTRS)

    Perry, J. L.; Tomes, K. M.; Tatara, J. D.

    2005-01-01

    Contaminated air, whether in a crewed spacecraft cabin or terrestrial work and living spaces, is a pervasive problem affecting human health, performance, and well being. The need for highly effective, economical air quality processes spans a wide range of terrestrial and space flight applications. Typically, air quality control processes rely on absorption-based processes. Most industrial packed-bed adsorption processes use activated carbon. Once saturated, the carbon is either dumped or regenerated. In either case, the dumped carbon and concentrated waste streams constitute a hazardous waste that must be handled safely while minimizing environmental impact. Thermal catalytic oxidation processes designed to address waste handling issues are moving to the forefront of cleaner air quality control and process gas decontamination processes. Careful consideration in designing the catalyst substrate and reactor can lead to more complete contaminant destruction and poisoning resistance. Maintenance improvements leading to reduced waste handling and process downtime can also be realized. Performance of a prototype thermal catalytic reaction based on ultra-short waste channel, monolith catalyst substrate design, under a variety of process flow and contaminant loading conditions, is discussed.

  9. Infection prevention and control in the design of healthcare facilities.

    PubMed

    Farrow, Tye S; Black, Stephen M

    2009-01-01

    The lead paper, "Healthcare-Associated Infections as Patient Safety Indicators," written by Gardam, Lemieux, Reason, van Dijk and Goel, puts forward the design of healthcare facilities as one of many strategies to improve patient safety with respect to healthcare-associated infections. This commentary explores some of the issues in balancing infection prevention and control priorities with other needs and values brought to the design process. This balance is challenged not only by a lack of supporting evidence but also by the superficial nature in which infection prevention and control are often discussed within a design context. For the physical environment to support any patient safety initiative, the design of the processes must be developed in conjunction with that of the physical environment so that compliance can be natural and convenient. Finally, consideration is given to the value of documenting decision-making related to infection prevention and control in facility design and ongoing assessments of existing facilities.

  10. Worldwide legislative challenges related to psychoactive drugs.

    PubMed

    Negrei, Carolina; Galateanu, Bianca; Stan, Miriana; Balalau, Cristian; Dumitru, Mircea Lucian Bogdan; Ozcagli, Eren; Fenga, Concettina; Kovatsi, Leda; Fragou, Domniki; Tsatsakis, Aristidis

    2017-06-02

    The discovery of a "new" psychoactive substance is a relatively exceptional event, while the regulatory response usually involved the assessment of risks to public health and inclusion of the novel substance in the national list of controlled substances. However, in recent years we have witnessed the rapid emergence of new chemical substances, which elude international control and pose a challenge to existing processes and a threat to the credibility of control systems. We currently review and present characteristics of these legal and illegal new substances and issues regarding their global monitoring and regulatory measures already taken, or in the process of being taken, for their control. The concept of prohibition applied in active substance-related legislation is rather hazard ridden as balance is required between the ban on substances of potential therapeutic use and the access on the market of high-risk substances. Current and future laws regarding psychoactive compounds.

  11. Adaptive control and noise suppression by a variable-gain gradient algorithm

    NASA Technical Reports Server (NTRS)

    Merhav, S. J.; Mehta, R. S.

    1987-01-01

    An adaptive control system based on normalized LMS filters is investigated. The finite impulse response of the nonparametric controller is adaptively estimated using a given reference model. Specifically, the following issues are addressed: The stability of the closed loop system is analyzed and heuristically established. Next, the adaptation process is studied for piecewise constant plant parameters. It is shown that by introducing a variable-gain in the gradient algorithm, a substantial reduction in the LMS adaptation rate can be achieved. Finally, process noise at the plant output generally causes a biased estimate of the controller. By introducing a noise suppression scheme, this bias can be substantially reduced and the response of the adapted system becomes very close to that of the reference model. Extensive computer simulations validate these and demonstrate assertions that the system can rapidly adapt to random jumps in plant parameters.

  12. Evidence on public policy: methodological issues, political issues and examples.

    PubMed

    Attanasio, Orazio P

    2014-03-01

    In this paper I discuss how evidence on public policy is generated and in particular the issue of evaluation of public policies. In economics, the issue of attribution and the identification of causal links has recently received considerable attention. Important methodological issues have been tackled and new techniques have been proposed and used. Randomized Control Trials have become some sort of gold standard. However, they are not exempt from problems and have important limitations: in some case they cannot be constructed and, more generally, problems of external validity and transferability of results can be important. The paper then moves on to discuss the political economy of policy evaluations for policy evaluations to have an impact for the conduct of actual policy, it is important that the demand for evaluation comes directly from the policy making process and is generated endogenously within it. In this sense it is important that the institutional design of policy making is such that policy making institutions are incentivized to use rigorous evaluation in the process of designing policies and allocating resources to alternative options. Economists are currently involved in the design and evaluation of many policies, including policies about health, nutrition and education. The role they can play in these fields is not completely obvious. The paper argues that their main contribution is in the modelling of how individual reacts to incentives (including those provided by public policies).

  13. Issues and Techniques of CASE Integration With Configuration Management

    DTIC Science & Technology

    1992-03-01

    all four!) process architecture classes. For example, Frame Technology’s FrameMaker is a client/server tool because it provides server functions for... FrameMaker clients; it is a parent/child tool since a top-level control panel is used to "fork" child FrameMaker sessions; the "forked" FrameMaker ...sessions are persistent tools since they may be reused to create and modify any number of FrameMaker documents. Despite this, however, these process

  14. Army Airspace Command and Control (A2C2): Action Plan for Issue Resolution

    DTIC Science & Technology

    1993-09-01

    INFO Information INTEL Intelligence IPR In-Process Review IVIS Inter-Vehicular Information System JACC Joint Airspace Control Center JAOC Joint Air...base, centralized such as intelligence at Fort Huachuca and combat service support at Fort Lee , or a combination of both. It is no longer efficient to...Regiment (ATS) Ft. Bragg, NC 28307 ATTN: AFZF-ATS-C (LTC Ledbetter ) (919) 396-8899/7649 Bldg 87009, 16th Street Ft. Hood, TX 76544 Commander, 1st

  15. Transient Oscilliations in Mechanical Systems of Automatic Control with Random Parameters

    NASA Astrophysics Data System (ADS)

    Royev, B.; Vinokur, A.; Kulikov, G.

    2018-04-01

    Transient oscillations in mechanical systems of automatic control with random parameters is a relevant but insufficiently studied issue. In this paper, a modified spectral method was applied to investigate the problem. The nature of dynamic processes and the phase portraits are analyzed depending on the amplitude and frequency of external influence. It is evident from the obtained results, that the dynamic phenomena occurring in the systems with random parameters under external influence are complex, and their study requires further investigation.

  16. A standard satellite control reference model

    NASA Technical Reports Server (NTRS)

    Golden, Constance

    1994-01-01

    This paper describes a Satellite Control Reference Model that provides the basis for an approach to identify where standards would be beneficial in supporting space operations functions. The background and context for the development of the model and the approach are described. A process for using this reference model to trace top level interoperability directives to specific sets of engineering interface standards that must be implemented to meet these directives is discussed. Issues in developing a 'universal' reference model are also identified.

  17. ESSDERC (European Solid State Device Research Conference) 17th Held in Bologna, Italy on 14-17 September 1987

    DTIC Science & Technology

    1987-09-17

    T. J. Watson Research Center, Yorktown Heights, N.Y. 10598 Processing, design , and characterization issues are discussed for advanced field-effect...Graded-gate FET (GFET) Jan. 1969. designed to overcome these problems, was presented. The differential gate bias allows control [3] D. Misra, T.R...structure, the degree of freedom in zation [7) of the partially restricted active circuit or system design circuit layout, and area is to control the

  18. Using AI Planning Techniques to Automatically Generate Image Processing Procedures: A Preliminary Report

    NASA Technical Reports Server (NTRS)

    Chien, S.

    1994-01-01

    This paper describes work on the Multimission VICAR Planner (MVP) system to automatically construct executable image processing procedures for custom image processing requests for the JPL Multimission Image Processing Lab (MIPL). This paper focuses on two issues. First, large search spaces caused by complex plans required the use of hand encoded control information. In order to address this in a manner similar to that used by human experts, MVP uses a decomposition-based planner to implement hierarchical/skeletal planning at the higher level and then uses a classical operator based planner to solve subproblems in contexts defined by the high-level decomposition.

  19. PVD thermal barrier coating applications and process development for aircraft engines

    NASA Astrophysics Data System (ADS)

    Rigney, D. V.; Viguie, R.; Wortman, D. J.; Skelly, D. W.

    1997-06-01

    Thermal barrier coatings (TBCs) have been developed for application to aircraft engine components to improve service life in an increasingly hostile thermal environment. The choice of TBC type is related to the component, intended use, and economics. Selection of electron beam physical vapor deposition proc-essing for turbine blade is due in part to part size, surface finish requirements, thickness control needs, and hole closure issues. Process development of PVD TBCs has been carried out at several different sites, including GE Aircraft Engines (GEAE). The influence of processing variables on microstructure is dis-cussed, along with the GEAE development coater and initial experiences of pilot line operation.

  20. Controlling and policing substance use(rs).

    PubMed

    White, Tony

    2002-01-01

    Controlling drug use--a dynamic, global, politicalized process--is reviewed in terms of selected types of drugs, "natural levels" of drug demand and use, drug markets and the drug market environment, types of traffickers, illicit drug trade profits, approaches to drug control ("War on Drugs", "Zero Tolerance" programs and policies, "normalizing" and legalizing selected drugs), including UN's then relatively recent "Balanced Approach" and facets of drug law enforcement (drug prices and purity levels and values of drug seizures), including various rarely noted benefits to intervention programs and control agents. Unresolved issues and needed "tools" are noted while considering the implications of the first UN's World Drug Report data.

  1. [Anaerobic membrane bioreactors for treating agricultural and food processing wastewater at high strength].

    PubMed

    Wei, Yuan-Song; Yu, Da-Wei; Cao, Lei

    2014-04-01

    As the second largest amounts of COD discharged in 41 kinds of industrial wastewater, it is of great urgency for the agricultural and food processing industry to control water pollution and reduce pollutants. Generally the agricultural and food processing industrial wastewater with high strength COD of 8 000-30 000 mg x L(-1), is mainly treated with anaerobic and aerobic processes in series, but which exists some issues of long process, difficult maintenance and high operational costs. Through coupling anaerobic digestion and membrane separation together, anaerobic membrane bioreactor (AnMBR) has typical advantages of high COD removal efficiency (92%-99%), high COD organic loading rate [2.3-19.8 kg x (m3 x d)(-1)], little sludge discharged (SRT > 40 d) and low cost (HRT of 8-12 h). According to COD composition of high strength industrial wastewater, rate-limiting step of methanation could be either hydrolysis and acidification or methanogenesis. Compared with aerobic membrane bioreactor (MBR), membrane fouling of AnMBR is more complicated in characterization and more difficult in control. Measures for membrane fouling control of AnMBR are almost the same as those of MBR, including cross flow, air sparging and membrane relaxation. For meeting discharging standard of food processing wastewater with high strength, AnMBR is a promising technology with very short process, by enhancing COD removal efficiency, controlling membrane fouling and improving energy recovery.

  2. Benthic boundary layer processes in the Lower Florida Keys

    USGS Publications Warehouse

    Lavoie, D.L.; Richardson, M.D.; Holmes, C.

    1997-01-01

    This special issue of Geo-Marine Letters, "Benthic Boundary Layer Processes in the Lower Florida Keys," includes 12 papers that present preliminary results from the Key West Campaign. The Dry Tortugas and Marquesas Keys test sites were selected by a group of 115 scientists and technicians to study benthic boundary layer processes in a carbonate environment controlled by bioturbation and biogeochemical processes. Major activities included remote sediment classification; high-frequency acoustic scattering experiments; sediment sampling for radiological, geotechnical, biological, biogeochemical, physical, and geoacoustic studies; and hydrodynamic studies using an instrumented tetrapod. All these data are being used to improve our understanding of the effects of environmental processes on sediment structure and behavior.

  3. Problems and solutions in the field of improving control and supervision activities in the construction sector

    NASA Astrophysics Data System (ADS)

    Dikareva, Varvara; Mostovaya, Anna

    2018-03-01

    The improvement of control and supervision activities in high-rise construction is an important goal of the state. In the paper, the author considered the initiatives of the state in terms of improving the control activity. He shows the main approaches that will be applied by the state. The application of information and communication technologies in control activities is described in detail. It was noted that the quality of the regulation of various procedures remains a serious issue. At the same time, modern innovations in the field of control should take into account the increasing volumes of data and information about various economic processes.

  4. Performance Management as a Means of Teacher Evaluation: A South Australian Perspective

    ERIC Educational Resources Information Center

    Naidu, Sham

    2011-01-01

    The introduction of performance management in South Australian public schools raises a number of issues regarding the structure, purpose and control of the process itself and the consequences of teacher evaluation. Performance management has the potential to shape teaching and the culture of schools according to what it values and what it ignores.…

  5. Values Acquisition and Moral Development: An Integration of Freudian, Eriksonian, Kohlbergian and Gilliganian Viewpoints

    ERIC Educational Resources Information Center

    Herman, William E.

    2005-01-01

    Consider the following important questions: Should values be transmitted or developed? As children grow up, what, if anything, should change in values acquisition? How important are locus of control issues in moral development? and Why might process versus product elements be crucial in the development of values? One key element missing in the…

  6. 77 FR 42556 - Proposed Information Collection (Notice of Disagreement) Activity: Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-19

    ... information technology. Title: Notice of Disagreement, VA Form 21-0958. OMB Control Number: 2900-NEW. Type of... decision issued by Regional Office. This is the first step in the appeal process. The respondent may or may not continue with an appeal to the Board of Veterans Appeals (BVA). If the Veteran opts to continue to...

  7. Differential Effects of Social and Non-Social Reward on Response Inhibition in Children and Adolescents

    ERIC Educational Resources Information Center

    Kohls, Gregor; Peltzer, Judith; Herpertz-Dahlmann, Beate; Konrad, Kerstin

    2009-01-01

    An important issue in the field of clinical and developmental psychopathology is whether cognitive control processes, such as response inhibition, can be specifically enhanced by motivation. To determine whether non-social (i.e. monetary) and social (i.e. positive facial expressions) rewards are able to differentially improve response inhibition…

  8. The School of Hard Knocks. A Study on the Assessment of Experiential Learning.

    ERIC Educational Resources Information Center

    Thomson, Peter

    Australia's tertiary institutions and licensing authorities that control the right to work in various trades and professions have largely ignored the need for procedures and processes to recognize formally the knowledge that people gain in their life experiences. For this reason, the issue of assessing adult learners' life experiences for the…

  9. 75 FR 17003 - Reconsideration of Interpretation of Regulations That Determine Pollutants Covered by Clean Air...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-02

    ... Law Dictionary (8th Ed.) is ``the act or process of controlling by rule or restriction.'' However, an alternative meaning in this same dictionary defines the term as ``a rule or order, having legal force, usu. issued by an administrative agency or local government.'' The primary meaning in Webster's dictionary for...

  10. Processing of polysiloxane-derived porous ceramics: a review

    PubMed Central

    Manoj Kumar, B V; Kim, Young-Wook

    2010-01-01

    Because of the unique combination of their attractive properties, porous ceramics are considered as candidate materials for several engineering applications. The production of porous ceramics from polysiloxane precursors offers advantages in terms of simple processing methodology, low processing cost, and easy control over porosity and other properties of the resultant ceramics. Therefore, considerable research has been conducted to produce various Si(O)C-based ceramics from polysiloxane precursors by employing different processing strategies. The complete potential of these materials can only be achieved when properties are tailored for a specific application, whereas the control over these properties is highly dependent on the processing route. This review deals with processing strategies of polysiloxane-derived porous ceramics. The essential features of processing strategies—replica, sacrificial template, direct foaming and reaction techniques—are explained and the available literature reports are thoroughly reviewed with particular regard to the critical issues that affect pore characteristics. A short note on the cross-linking methods of polysiloxanes is also provided. The potential of each processing strategy on porosity and strength of the resultant SiC or SiOC ceramics is outlined. PMID:27877344

  11. EPA issues ANPR on significant new uses of lead

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bergeson, L.L.

    1994-12-01

    The US Environmental Protection Agency (EPA) signed off on an Advance Notice of Proposed Rulemaking (ANPR) for significant new uses of lead. The Significant New Use Rule (SNUR) would require people to notify EPA at least 90 days before commencing the manufacture, import or processing of lead and lead compounds for new uses. Section 5(a) of the Toxic Substances Control Act (TSCA) provides EPA with authority to screen new uses of a chemical substance to determine whether these uses should be regulated. The screening function is accomplished through the SNUR process. EPA may issue a SNUR for chemical substances aftermore » considering relevant factors including: the projected volume of manufacturing and processing of a chemical substance; the extent to which a use changes the type or form of human or environmental exposure to a chemical substance; the extent to which a new use increases the magnitude and duration of a human or environmental exposure to a chemical substance; and the reasonably anticipated manner and methods of manufacturing, processing, distribution in commerce and disposal of the chemical substance.« less

  12. Fuzzy logic control system to provide autonomous collision avoidance for Mars rover vehicle

    NASA Technical Reports Server (NTRS)

    Murphy, Michael G.

    1990-01-01

    NASA is currently involved with planning unmanned missions to Mars to investigate the terrain and process soil samples in advance of a manned mission. A key issue involved in unmanned surface exploration on Mars is that of supporting autonomous maneuvering since radio communication involves lengthy delays. It is anticipated that specific target locations will be designated for sample gathering. In maneuvering autonomously from a starting position to a target position, the rover will need to avoid a variety of obstacles such as boulders or troughs that may block the shortest path to the target. The physical integrity of the rover needs to be maintained while minimizing the time and distance required to attain the target position. Fuzzy logic lends itself well to building reliable control systems that function in the presence of uncertainty or ambiguity. The following major issues are discussed: (1) the nature of fuzzy logic control systems and software tools to implement them; (2) collision avoidance in the presence of fuzzy parameters; and (3) techniques for adaptation in fuzzy logic control systems.

  13. High frequency x-ray generator basics.

    PubMed

    Sobol, Wlad T

    2002-02-01

    The purpose of this paper is to present basic functional principles of high frequency x-ray generators. The emphasis is put on physical concepts that determine the engineering solutions to the problem of efficient generation and control of high voltage power required to drive the x-ray tube. The physics of magnetically coupled circuits is discussed first, as a background for the discussion of engineering issues related to high-frequency power transformer design. Attention is paid to physical processes that influence such factors as size, efficiency, and reliability of a high voltage power transformer. The basic electrical circuit of a high frequency generator is analyzed next, with focus on functional principles. This section investigates the role and function of basic components, such as power supply, inverter, and voltage doubler. Essential electronic circuits of generator control are then examined, including regulation of voltage, current and timing of electrical power delivery to the x-ray tube. Finally, issues related to efficient feedback control, including basic design of the AEC circuitry are reviewed.

  14. Development of an integrated control and measurement system

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Manges, W.W.

    1984-03-01

    This thesis presents a tutorial on the issues involved in the development of a minicomputer-based, distributed intelligence data acquisition and process control system to support complex experimental facilities. The particular system discussed in this thesis is under development for the Atomic Vapor Laser Isotope Separation (AVLIS) Program at the Oak Ridge Gaseous Diffusion Plant (ORGDP). In the AVLIS program, we were careful to integrate the computer sections of the implementation into the instrumentation system rather than adding them as an appendage. We then addressed the reliability and availability of the system as a separate concern. Thus, our concept of anmore » integrated control and measurement (ICAM) system forms the basis for this thesis. This thesis details the logic and philosophy that went into the development of this system and explains why the commercially available turn-key systems generally are not suitable. Also, the issues involved in the specification of the components for such an integrated system are emphasized.« less

  15. Understanding current steam sterilization recommendations and guidelines.

    PubMed

    Spry, Cynthia

    2008-10-01

    Processing surgical instruments in preparation for surgery is a complex multistep practice. It is impractical to culture each and every item to determine sterility; therefore, the best assurance of a sterile product is careful execution of every step in the process coupled with an ongoing quality control program. Perioperative staff nurses and managers responsible for instrument processing, whether for a single instrument or multiple sets, must be knowledgeable with regard to cleaning; packaging; cycle selection; and the use of physical, chemical, and biological monitors. Nurses also should be able to resolve issues related to loaner sets, flash sterilization, and extended cycles.

  16. High-efficiency high-reliability optical components for a large, high-average-power visible laser system

    NASA Astrophysics Data System (ADS)

    Taylor, John R.; Stolz, Christopher J.

    1993-08-01

    Laser system performance and reliability depends on the related performance and reliability of the optical components which define the cavity and transport subsystems. High-average-power and long transport lengths impose specific requirements on component performance. The complexity of the manufacturing process for optical components requires a high degree of process control and verification. Qualification has proven effective in ensuring confidence in the procurement process for these optical components. Issues related to component reliability have been studied and provide useful information to better understand the long term performance and reliability of the laser system.

  17. High-efficiency high-reliability optical components for a large, high-average-power visible laser system

    NASA Astrophysics Data System (ADS)

    Taylor, J. R.; Stolz, C. J.

    1992-12-01

    Laser system performance and reliability depends on the related performance and reliability of the optical components which define the cavity and transport subsystems. High-average-power and long transport lengths impose specific requirements on component performance. The complexity of the manufacturing process for optical components requires a high degree of process control and verification. Qualification has proven effective in ensuring confidence in the procurement process for these optical components. Issues related to component reliability have been studied and provide useful information to better understand the long term performance and reliability of the laser system.

  18. Instrument control software requirement specification for Extremely Large Telescopes

    NASA Astrophysics Data System (ADS)

    Young, Peter J.; Kiekebusch, Mario J.; Chiozzi, Gianluca

    2010-07-01

    Engineers in several observatories are now designing the next generation of optical telescopes, the Extremely Large Telescopes (ELT). These are very complex machines that will host sophisticated astronomical instruments to be used for a wide range of scientific studies. In order to carry out scientific observations, a software infrastructure is required to orchestrate the control of the multiple subsystems and functions. This paper will focus on describing the considerations, strategies and main issues related to the definition and analysis of the software requirements for the ELT's Instrument Control System using modern development processes and modelling tools like SysML.

  19. Laser processing for manufacturing nanocarbon materials

    NASA Astrophysics Data System (ADS)

    Van, Hai Hoang

    CNTs have been considered as the excellent candidate to revolutionize a broad range of applications. There have been many method developed to manipulate the chemistry and the structure of CNTs. Laser with non-contact treatment capability exhibits many processing advantages, including solid-state treatment, extremely fast processing rate, and high processing resolution. In addition, the outstanding monochromatic, coherent, and directional beam generates the powerful energy absorption and the resultant extreme processing conditions. In my research, a unique laser scanning method was developed to process CNTs, controlling the oxidation and the graphitization. The achieved controllability of this method was applied to address the important issues of the current CNT processing methods for three applications. The controllable oxidation of CNTs by laser scanning method was applied to cut CNT films to produce high-performance cathodes for FE devices. The production method includes two important self-developed techniques to produce the cold cathodes: the production of highly oriented and uniformly distributed CNT sheets and the precise laser trimming process. Laser cutting is the unique method to produce the cathodes with remarkable features, including ultrathin freestanding structure (~200 nm), greatly high aspect ratio, hybrid CNT-GNR emitter arrays, even emitter separation, and directional emitter alignment. This unique cathode structure was unachievable by other methods. The developed FE devices successfully solved the screening effect issue encounter by current FE devices. The laser-control oxidation method was further developed to sequentially remove graphitic walls of CNTs. The laser oxidation process was directed to occur along the CNT axes by the laser scanning direction. Additionally, the oxidation was further assisted by the curvature stress and the thermal expansion of the graphitic nanotubes, ultimately opening (namely unzipping) the tubular structure to produce GNRs. Therefore the developed laser scanning method optimally exploited the thermal laser-CNT interaction, successfully transforming CNTs into 2D GNRs. The solid-state laser unzipping process effectively addressed the issues of contamination and scalability encountered by the current unzipping methods. Additionally, the produced GNRs were uniquely featured with the freestanding structure and the smooth surfaces. If the scanning process was performed in an inert environment without the appearance of oxygen, the oxidation of CNTs would not happen. Instead, the greatly mobile carbon atoms of the heated CNTs would reorganize the crystal structure, inducing the graphitization process to improve the crystallinity. Many observations showing the structural improvement of CNTs under laser irradiation has been reported, confirming the capability of laser to heal graphitic defects. Laser methods were more time-efficient and energy-efficient than other annealing methods because laser can quickly heat CNTs to generate graphitization in less than one second. This subsecond heating process of laser irradiation was more effective than other heating methods because it avoided the undesired coalescence of CNTs. In my research, the laser scanning method was applied to generate the graphitization, healing the structural defects of CNTs. Different from the reported laser methods, the laser scanning directed the locally annealed areas to move along the CNT axes, migrating and coalescencing the graphitic defects to achieve better healing results. The critical information describing the CNT structural transformation caused by the moving laser irradiation was explored from the successful applications of the developed laser method. This knowledge inspires an important method to modifiy the general graphitic structure for important applications, such as carbon fiber production, CNT self-assembly process and CNT welding. This method will be effective, facile, versatile, and adaptable for laboratory and industrial facilities.

  20. Is content of medical journals related to advertisements? Case-control study.

    PubMed

    Vlassov, Vasiliy V

    2007-12-01

    To assess the relatedness of journal content to paid advertisements published in the journal. The case-control study was performed on a convenience sample of 7 journals subscribed by Central Medical Library in Moscow--4 international (American Journal of Hypertension, British Journal of General Practice, The Lancet, and New England Journal of Medicine) and 3 Russian peer reviewed journals (Terapevticheskii Arkhiv, Khirurgiia, and Voeno-Meditsinskii Zhurnal). In each issue containing a paid advertisement, classifieds excluded, we searched for articles related to the advertised product and compared this issue with a control issue - the next or a later issue without this advertisement. In American Journal of Hypertension (33 issues from 2002-2004) 94 placements of advertisements were found, 7 of which were closely related to the article topic in the same issue (7/94) vs 2/66 in the control issue. The odds ratio (OR) and 95% confidence interval (CI) for advertisements to be accompanied by related articles was OR, 2.6; 95%CI, 0.5-13). In British Journal of General Practice (27 issues from 2003-2005) there were 7/63 advertisements related to the article topic vs 0/28 in the control issue (OR, 7.2; 95% CI, 1.3 to 44). In The Lancet (49 issues from 2004) there were 8/162 advertisements related to the article topic vs 8/104 in the control issue (OR, 0.6; 95% CI, 0.3-1.5). In New England Journal of Medicine (37 issues from 2004) there were 12/81 advertisements related to the article topic vs 8/75 in the control issue (OR, 1.5; 95% CI, 0.56-3.79). In Terapevticheskii Arkhiv (10 issues from 2004) there were 38/93 advertisements related to the article topic vs 1/83 in the control issue (OR, 56.66; 95% CI, 4.4-253). In Khirurgiia (25 issues from 2003-2005) there were 3/83 advertisements related to the article topic vs 0/70 in the control issue (OR, 2.7; 95% CI, 0.3-26). In Voeno-Meditsinskii Zhurnal (33 issues from 2003-2005) there were 17/31 advertisements related to the article topic vs 2/31 in the control issue (OR,17.6; 95% CI, 3.6-87). The strong relatedness between the content of the articles and advertisements placed in 3 of 7 journals and explicit placement of the advertisements face to face or overleaf the related research articles support the hypothesis that journal content is manipulated to place more emphasis on the advertisements.

  1. Is Content of Medical Journals Related to Advertisements? Case-control Study

    PubMed Central

    Vlassov, Vasiliy V.

    2007-01-01

    Aim To assess the relatedness of journal content to paid advertisements published in the journal. Methods The case-control study was performed on a convenience sample of 7 journals subscribed by Central Medical Library in Moscow – 4 international (American Journal of Hypertension, British Journal of General Practice, The Lancet, and New England Journal of Medicine) and 3 Russian peer reviewed journals (Terapevticheskii Arkhiv, Khirurgiia, and Voeno-Meditsinskii Zhurnal). In each issue containing a paid advertisement, classifieds excluded, we searched for articles related to the advertised product and compared this issue with a control issue – the next or a later issue without this advertisement. Results In American Journal of Hypertension (33 issues from 2002-2004) 94 placements of advertisements were found, 7 of which were closely related to the article topic in the same issue (7/94) vs 2/66 in the control issue. The odds ratio (OR) and 95% confidence interval (CI) for advertisements to be accompanied by related articles was OR, 2.6; 95%CI, 0.5-13). In British Journal of General Practice (27 issues from 2003-2005) there were 7/63 advertisements related to the article topic vs 0/28 in the control issue (OR, 7.2; 95% CI, 1.3 to 44). In The Lancet (49 issues from 2004) there were 8/162 advertisements related to the article topic vs 8/104 in the control issue (OR, 0.6; 95% CI, 0.3-1.5). In New England Journal of Medicine (37 issues from 2004) there were 12/81 advertisements related to the article topic vs 8/75 in the control issue (OR, 1.5; 95% CI, 0.56-3.79). In Terapevticheskii Arkhiv (10 issues from 2004) there were 38/93 advertisements related to the article topic vs 1/83 in the control issue (OR, 56.66; 95% CI, 4.4-253). In Khirurgiia (25 issues from 2003-2005) there were 3/83 advertisements related to the article topic vs 0/70 in the control issue (OR, 2.7; 95% CI, 0.3-26). In Voeno-Meditsinskii Zhurnal (33 issues from 2003-2005) there were 17/31 advertisements related to the article topic vs 2/31 in the control issue (OR,17.6; 95% CI, 3.6-87). Conclusions The strong relatedness between the content of the articles and advertisements placed in 3 of 7 journals and explicit placement of the advertisements face to face or overleaf the related research articles support the hypothesis that journal content is manipulated to place more emphasis on the advertisements. PMID:18074412

  2. Training in Decision-making Strategies: An approach to enhance students' competence to deal with socio-scientific issues

    NASA Astrophysics Data System (ADS)

    Gresch, Helge; Hasselhorn, Marcus; Bögeholz, Susanne

    2013-10-01

    Dealing with socio-scientific issues in science classes enables students to participate productively in controversial discussions concerning ethical topics, such as sustainable development. In this respect, well-structured decision-making processes are essential for elaborate reasoning. To foster decision-making competence, a computer-based programme was developed that trains secondary school students (grades 11-13) in decision-making strategies. The main research question is: does training students to use these strategies foster decision-making competence? In addition, the influence of meta-decision aids was examined. Students conducted a task analysis to select an appropriate strategy prior to the decision-making process. Hence, the second research question is: does combining decision-making training with a task analysis enhance decision-making competence at a higher rate? To answer these questions, 386 students were tested in a pre-post-follow-up control-group design that included two training groups (decision-making strategies/decision-making strategies combined with a task analysis) and a control group (decision-making with additional ecological information instead of strategic training). An open-ended questionnaire was used to assess decision-making competence in situations related to sustainable development. The decision-making training led to a significant improvement in the post-test and the follow-up, which was administered three months after the training. Long-term effects on the quality of the students' decisions were evident for both training groups. Gains in competence when reflecting upon the decision-making processes of others were found, to a lesser extent, in the training group that received the additional meta-decision training. In conclusion, training in decision-making strategies is a promising approach to deal with socio-scientific issues related to sustainable development.

  3. Integrated Application of Quality-by-Design Principles to Drug Product Development: A Case Study of Brivanib Alaninate Film-Coated Tablets.

    PubMed

    Badawy, Sherif I F; Narang, Ajit S; LaMarche, Keirnan R; Subramanian, Ganeshkumar A; Varia, Sailesh A; Lin, Judy; Stevens, Tim; Shah, Pankaj A

    2016-01-01

    Modern drug product development is expected to follow quality-by-design (QbD) paradigm. At the same time, although there are several issue-specific examples in the literature that demonstrate the application of QbD principles, a holistic demonstration of the application of QbD principles to drug product development and control strategy, is lacking. This article provides an integrated case study on the systematic application of QbD to product development and demonstrates the implementation of QbD concepts in the different aspects of product and process design for brivanib alaninate film-coated tablets. Using a risk-based approach, the strategy for development entailed identification of product critical quality attributes (CQAs), assessment of risks to the CQAs, and performing experiments to understand and mitigate identified risks. Quality risk assessments and design of experiments were performed to understand the quality of the input raw materials required for a robust formulation and the impact of manufacturing process parameters on CQAs. In addition to the material property and process parameter controls, the proposed control strategy includes use of process analytical technology and conventional analytical tests to control in-process material attributes and ensure quality of the final product. Copyright © 2016. Published by Elsevier Inc.

  4. Visual Servoing for an Autonomous Hexarotor Using a Neural Network Based PID Controller.

    PubMed

    Lopez-Franco, Carlos; Gomez-Avila, Javier; Alanis, Alma Y; Arana-Daniel, Nancy; Villaseñor, Carlos

    2017-08-12

    In recent years, unmanned aerial vehicles (UAVs) have gained significant attention. However, we face two major drawbacks when working with UAVs: high nonlinearities and unknown position in 3D space since it is not provided with on-board sensors that can measure its position with respect to a global coordinate system. In this paper, we present a real-time implementation of a servo control, integrating vision sensors, with a neural proportional integral derivative (PID), in order to develop an hexarotor image based visual servo control (IBVS) that knows the position of the robot by using a velocity vector as a reference to control the hexarotor position. This integration requires a tight coordination between control algorithms, models of the system to be controlled, sensors, hardware and software platforms and well-defined interfaces, to allow the real-time implementation, as well as the design of different processing stages with their respective communication architecture. All of these issues and others provoke the idea that real-time implementations can be considered as a difficult task. For the purpose of showing the effectiveness of the sensor integration and control algorithm to address these issues on a high nonlinear system with noisy sensors as cameras, experiments were performed on the Asctec Firefly on-board computer, including both simulation and experimenta results.

  5. Visual Servoing for an Autonomous Hexarotor Using a Neural Network Based PID Controller

    PubMed Central

    Lopez-Franco, Carlos; Alanis, Alma Y.; Arana-Daniel, Nancy; Villaseñor, Carlos

    2017-01-01

    In recent years, unmanned aerial vehicles (UAVs) have gained significant attention. However, we face two major drawbacks when working with UAVs: high nonlinearities and unknown position in 3D space since it is not provided with on-board sensors that can measure its position with respect to a global coordinate system. In this paper, we present a real-time implementation of a servo control, integrating vision sensors, with a neural proportional integral derivative (PID), in order to develop an hexarotor image based visual servo control (IBVS) that knows the position of the robot by using a velocity vector as a reference to control the hexarotor position. This integration requires a tight coordination between control algorithms, models of the system to be controlled, sensors, hardware and software platforms and well-defined interfaces, to allow the real-time implementation, as well as the design of different processing stages with their respective communication architecture. All of these issues and others provoke the idea that real-time implementations can be considered as a difficult task. For the purpose of showing the effectiveness of the sensor integration and control algorithm to address these issues on a high nonlinear system with noisy sensors as cameras, experiments were performed on the Asctec Firefly on-board computer, including both simulation and experimenta results. PMID:28805689

  6. Robust energy-absorbing compensators for the ACTEX II test article

    NASA Astrophysics Data System (ADS)

    Blaurock, Carl A.; Miller, David W.; Nye, Ted

    1995-05-01

    The paper addresses the problem of satellite solar panel vibration. A multi-layer vibration control scheme is investigated using a flight test article. Key issues in the active control portion are presented in the paper. The paper discusses the primary control design drivers, which are the time variations in modal frequencies due to configuration and thermal changes. A local control design approach is investigated, but found to be unworkable due to sensor/actuator non-collocation. An alternate design process uses linear robust control techniques, by describing the modal shifts as uncertainties. Multiple modal design, alpha- shifted multiple model, and a feedthrough compensation scheme are examined. Ground and simulation tests demonstrate that the resulting controllers provide significant vibration reduction in the presence of expected system variations.

  7. Generic System for Remote Testing and Calibration of Measuring Instruments: Security Architecture

    NASA Astrophysics Data System (ADS)

    Jurčević, M.; Hegeduš, H.; Golub, M.

    2010-01-01

    Testing and calibration of laboratory instruments and reference standards is a routine activity and is a resource and time consuming process. Since many of the modern instruments include some communication interfaces, it is possible to create a remote calibration system. This approach addresses a wide range of possible applications and permits to drive a number of different devices. On the other hand, remote calibration process involves a number of security issues due to recommendations specified in standard ISO/IEC 17025, since it is not under total control of the calibration laboratory personnel who will sign the calibration certificate. This approach implies that the traceability and integrity of the calibration process directly depends on the collected measurement data. The reliable and secure remote control and monitoring of instruments is a crucial aspect of internet-enabled calibration procedure.

  8. On discrete control of nonlinear systems with applications to robotics

    NASA Technical Reports Server (NTRS)

    Eslami, Mansour

    1989-01-01

    Much progress has been reported in the areas of modeling and control of nonlinear dynamic systems in a continuous-time framework. From implementation point of view, however, it is essential to study these nonlinear systems directly in a discrete setting that is amenable for interfacing with digital computers. But to develop discrete models and discrete controllers for a nonlinear system such as robot is a nontrivial task. Robot is also inherently a variable-inertia dynamic system involving additional complications. Not only the computer-oriented models of these systems must satisfy the usual requirements for such models, but these must also be compatible with the inherent capabilities of computers and must preserve the fundamental physical characteristics of continuous-time systems such as the conservation of energy and/or momentum. Preliminary issues regarding discrete systems in general and discrete models of a typical industrial robot that is developed with full consideration of the principle of conservation of energy are presented. Some research on the pertinent tactile information processing is reviewed. Finally, system control methods and how to integrate these issues in order to complete the task of discrete control of a robot manipulator are also reviewed.

  9. A nonlinear disturbance-decoupled elevation axis controller for the Multiple Mirror Telescope

    NASA Astrophysics Data System (ADS)

    Clark, Dusty; Trebisky, Tom; Powell, Keith

    2008-07-01

    The Multiple Mirror Telescope (MMT), upgraded in 2000 to a monolithic 6.5m primary mirror from its original array of six 1.8m primary mirrors, was commissioned with axis controllers designed early in the upgrade process without regard to structural resonances or the possibility of the need for digital filtering of the control axis signal path. Post-commissioning performance issues led us to investigate replacement of the original control system with a more modern digital controller with full control over the system filters and gain paths. This work, from system identification through controller design iteration by simulation, and pre-deployment hardware-in-the-loop testing, was performed using latest-generation tools with Matlab® and Simulink®. Using Simulink's Real Time Workshop toolbox to automatically generate C source code for the controller from the Simulink diagram and a custom target build script, we were able to deploy the new controller into our existing software infrastructure running Wind River's VxWorks™real-time operating system. This paper describes the process of the controller design, including system identification data collection, with discussion of implementation of non-linear control modes and disturbance decoupling, which became necessary to obtain acceptable wind buffeting rejection.

  10. Banishing the Control Homunculi in Studies of Action Control and Behavior Change

    PubMed Central

    Verbruggen, Frederick; McLaren, Ian P. L.; Chambers, Christopher D.

    2014-01-01

    For centuries, human self-control has fascinated scientists and nonscientists alike. Current theories often attribute it to an executive control system. But even though executive control receives a great deal of attention across disciplines, most aspects of it are still poorly understood. Many theories rely on an ill-defined set of “homunculi” doing jobs like “response inhibition” or “updating” without explaining how they do so. Furthermore, it is not always appreciated that control takes place across different timescales. These two issues hamper major advances. Here we focus on the mechanistic basis for the executive control of actions. We propose that at the most basic level, action control depends on three cognitive processes: signal detection, action selection, and action execution. These processes are modulated via error-correction or outcome-evaluation mechanisms, preparation, and task rules maintained in working and long-term memory. We also consider how executive control of actions becomes automatized with practice and how people develop a control network. Finally, we discuss how the application of this unified framework in clinical domains can increase our understanding of control deficits and provide a theoretical basis for the development of novel behavioral change interventions. PMID:25419227

  11. Neural signature of reward-modulated unconscious inhibitory control.

    PubMed

    Diao, Liuting; Qi, Senqing; Xu, Mengsi; Li, Zhiai; Ding, Cody; Chen, Antao; Zheng, Yan; Yang, Dong

    2016-09-01

    Consciously initiated cognitive control is generally determined by motivational incentives (e.g., monetary reward). Recent studies have revealed that human cognitive control processes can nevertheless operate without awareness. However, whether monetary reward can impinge on unconscious cognitive control remains unclear. To clarify this issue, a task consisting of several runs was designed to combine a modified version of the reward-priming paradigm with an unconscious version of the Go/No-Go task. At the beginning of each run, participants were exposed to a high- or low-value coin, followed by the modified Go/No-Go task. Participants could earn the coin only if they responded correctly to each trial of the run. Event-related potential (ERP) results indicated that high-value rewards (vs. low-value rewards) induced a greater centro-parietal P3 component associated with conscious and unconscious inhibitory control. Moreover, the P3 amplitude correlated positively with the magnitude of reaction time slowing reflecting the intensity of activation of unconscious inhibitory control in the brain. These findings suggest that high-value reward may facilitate human higher-order inhibitory processes that are independent of conscious awareness, which provides insights into the brain processes that underpin motivational modulation of cognitive control. Copyright © 2016 Elsevier B.V. All rights reserved.

  12. Clinical process analysis and activity-based costing at a heart center.

    PubMed

    Ridderstolpe, Lisa; Johansson, Andreas; Skau, Tommy; Rutberg, Hans; Ahlfeldt, Hans

    2002-08-01

    Cost studies, productivity, efficiency, and quality of care measures, the links between resources and patient outcomes, are fundamental issues for hospital management today. This paper describes the implementation of a model for process analysis and activity-based costing (ABC)/management at a Heart Center in Sweden as a tool for administrative cost information, strategic decision-making, quality improvement, and cost reduction. A commercial software package (QPR) containing two interrelated parts, "ProcessGuide and CostControl," was used. All processes at the Heart Center were mapped and graphically outlined. Processes and activities such as health care procedures, research, and education were identified together with their causal relationship to costs and products/services. The construction of the ABC model in CostControl was time-consuming. However, after the ABC/management system was created, it opened the way for new possibilities including process and activity analysis, simulation, and price calculations. Cost analysis showed large variations in the cost obtained for individual patients undergoing coronary artery bypass grafting (CABG) surgery. We conclude that a process-based costing system is applicable and has the potential to be useful in hospital management.

  13. Pumped storage system model and experimental investigations on S-induced issues during transients

    NASA Astrophysics Data System (ADS)

    Zeng, Wei; Yang, Jiandong; Hu, Jinhong

    2017-06-01

    Because of the important role of pumped storage stations in the peak regulation and frequency control of a power grid, pump turbines must rapidly switch between different operating modes, such as fast startup and load rejection. However, pump turbines go through the unstable S region in these transition processes, threatening the security and stability of the pumped storage station. This issue has mainly been investigated through numerical simulations, while field experiments generally involve high risks and are difficult to perform. Therefore, in this work, the model test method was employed to study S-induced security and stability issues for a pumped storage station in transition processes. First, a pumped storage system model was set up, including the piping system, model units, electrical control systems and measurement system. In this model, two pump turbines with different S-shaped characteristics were installed to determine the influence of S-shaped characteristics on transition processes. The model platform can be applied to simulate any hydraulic transition process that occurs in real power stations, such as load rejection, startup, and grid connection. On the experimental platform, the S-shaped characteristic curves were measured to be the basis of other experiments. Runaway experiments were performed to verify the impact of the S-shaped characteristics on the pump turbine runaway stability. Full load rejection tests were performed to validate the effect of the S-shaped characteristics on the water-hammer pressure. The condition of one pump turbine rejecting its load after another defined as one-after-another (OAA) load rejection was performed to validate the possibility of S-induced extreme draft tube pressure. Load rejection experiments with different guide vane closing schemes were performed to determine a suitable scheme to adapt the S-shaped characteristics. Through these experiments, the threats existing in the station were verified, the appropriate measures were summarized, and an important experimental basis for the safe and stable operation of a pumped storage station was provided.

  14. Atomically Traceable Nanostructure Fabrication

    PubMed Central

    Ballard, Josh B.; Dick, Don D.; McDonnell, Stephen J.; Bischof, Maia; Fu, Joseph; Owen, James H. G.; Owen, William R.; Alexander, Justin D.; Jaeger, David L.; Namboodiri, Pradeep; Fuchs, Ehud; Chabal, Yves J.; Wallace, Robert M.; Reidy, Richard; Silver, Richard M.; Randall, John N.; Von Ehr, James

    2015-01-01

    Reducing the scale of etched nanostructures below the 10 nm range eventually will require an atomic scale understanding of the entire fabrication process being used in order to maintain exquisite control over both feature size and feature density. Here, we demonstrate a method for tracking atomically resolved and controlled structures from initial template definition through final nanostructure metrology, opening up a pathway for top-down atomic control over nanofabrication. Hydrogen depassivation lithography is the first step of the nanoscale fabrication process followed by selective atomic layer deposition of up to 2.8 nm of titania to make a nanoscale etch mask. Contrast with the background is shown, indicating different mechanisms for growth on the desired patterns and on the H passivated background. The patterns are then transferred into the bulk using reactive ion etching to form 20 nm tall nanostructures with linewidths down to ~6 nm. To illustrate the limitations of this process, arrays of holes and lines are fabricated. The various nanofabrication process steps are performed at disparate locations, so process integration is discussed. Related issues are discussed including using fiducial marks for finding nanostructures on a macroscopic sample and protecting the chemically reactive patterned Si(100)-H surface against degradation due to atmospheric exposure. PMID:26274555

  15. Atomically Traceable Nanostructure Fabrication.

    PubMed

    Ballard, Josh B; Dick, Don D; McDonnell, Stephen J; Bischof, Maia; Fu, Joseph; Owen, James H G; Owen, William R; Alexander, Justin D; Jaeger, David L; Namboodiri, Pradeep; Fuchs, Ehud; Chabal, Yves J; Wallace, Robert M; Reidy, Richard; Silver, Richard M; Randall, John N; Von Ehr, James

    2015-07-17

    Reducing the scale of etched nanostructures below the 10 nm range eventually will require an atomic scale understanding of the entire fabrication process being used in order to maintain exquisite control over both feature size and feature density. Here, we demonstrate a method for tracking atomically resolved and controlled structures from initial template definition through final nanostructure metrology, opening up a pathway for top-down atomic control over nanofabrication. Hydrogen depassivation lithography is the first step of the nanoscale fabrication process followed by selective atomic layer deposition of up to 2.8 nm of titania to make a nanoscale etch mask. Contrast with the background is shown, indicating different mechanisms for growth on the desired patterns and on the H passivated background. The patterns are then transferred into the bulk using reactive ion etching to form 20 nm tall nanostructures with linewidths down to ~6 nm. To illustrate the limitations of this process, arrays of holes and lines are fabricated. The various nanofabrication process steps are performed at disparate locations, so process integration is discussed. Related issues are discussed including using fiducial marks for finding nanostructures on a macroscopic sample and protecting the chemically reactive patterned Si(100)-H surface against degradation due to atmospheric exposure.

  16. Part height control of laser metal additive manufacturing process

    NASA Astrophysics Data System (ADS)

    Pan, Yu-Herng

    Laser Metal Deposition (LMD) has been used to not only make but also repair damaged parts in a layer-by-layer fashion. Parts made in this manner may produce less waste than those made through conventional machining processes. However, a common issue of LMD involves controlling the deposition's layer thickness. Accuracy is important, and as it increases, both the time required to produce the part and the material wasted during the material removal process (e.g., milling, lathe) decrease. The deposition rate is affected by multiple parameters, such as the powder feed rate, laser input power, axis feed rate, material type, and part design, the values of each of which may change during the LMD process. Using a mathematical model to build a generic equation that predicts the deposition's layer thickness is difficult due to these complex parameters. In this thesis, we propose a simple method that utilizes a single device. This device uses a pyrometer to monitor the current build height, thereby allowing the layer thickness to be controlled during the LMD process. This method also helps the LMD system to build parts even with complex parameters and to increase material efficiency.

  17. Reinventing The Design Process: Teams and Models

    NASA Technical Reports Server (NTRS)

    Wall, Stephen D.

    1999-01-01

    The future of space mission designing will be dramatically different from the past. Formerly, performance-driven paradigms emphasized data return with cost and schedule being secondary issues. Now and in the future, costs are capped and schedules fixed-these two variables must be treated as independent in the design process. Accordingly, JPL has redesigned its design process. At the conceptual level, design times have been reduced by properly defining the required design depth, improving the linkages between tools, and managing team dynamics. In implementation-phase design, system requirements will be held in crosscutting models, linked to subsystem design tools through a central database that captures the design and supplies needed configuration management and control. Mission goals will then be captured in timelining software that drives the models, testing their capability to execute the goals. Metrics are used to measure and control both processes and to ensure that design parameters converge through the design process within schedule constraints. This methodology manages margins controlled by acceptable risk levels. Thus, teams can evolve risk tolerance (and cost) as they would any engineering parameter. This new approach allows more design freedom for a longer time, which tends to encourage revolutionary and unexpected improvements in design.

  18. Optimization of controlled processes in combined-cycle plant (new developments and researches)

    NASA Astrophysics Data System (ADS)

    Tverskoy, Yu S.; Muravev, I. K.

    2017-11-01

    All modern complex technical systems, including power units of TPP and nuclear power plants, work in the system-forming structure of multifunctional APCS. The development of the modern APCS mathematical support allows bringing the automation degree to the solution of complex optimization problems of equipment heat-mass-exchange processes in real time. The difficulty of efficient management of a binary power unit is related to the need to solve jointly at least three problems. The first problem is related to the physical issues of combined-cycle technologies. The second problem is determined by the criticality of the CCGT operation to changes in the regime and climatic factors. The third problem is related to a precise description of a vector of controlled coordinates of a complex technological object. To obtain a joint solution of this complex of interconnected problems, the methodology of generalized thermodynamic analysis, methods of the theory of automatic control and mathematical modeling are used. In the present report, results of new developments and studies are shown. These results allow improving the principles of process control and the automatic control systems structural synthesis of power units with combined-cycle plants that provide attainable technical and economic efficiency and operational reliability of equipment.

  19. The Integration of COTS/GOTS within NASA's HST Command and Control System

    NASA Technical Reports Server (NTRS)

    Pfarr, Thomas; Reis, James E.; Obenschain, Arthur F. (Technical Monitor)

    2001-01-01

    NASA's mission critical Hubble Space Telescope (HST) command and control system has been re-engineered with COTS/GOTS and minimal custom code. This paper focuses on the design of this new HST Control Center System (CCS) and the lessons learned throughout its development. CCS currently utilizes 31 COTS/GOTS products with an additional 12 million lines of custom glueware code; the new CCS exceeds the capabilities of the original system while significantly reducing the lines of custom code by more than 50%. The lifecycle of COTS/GOTS products will be examined including the pack-age selection process, evaluation process, and integration process. The advantages, disadvantages, issues, concerns, and lessons teamed for integrating COTS/GOTS into the NASA's mission critical HST CCS will be examined in detail. Command and control systems designed with traditional custom code development efforts will be compared with command and control systems designed with new development techniques relying heavily on COTS/COTS integration. This paper will reveal the many hidden costs of COTS/GOTS solutions when compared to traditional custom code development efforts; this paper will show the high cost of COTS/GOTS solutions including training expenses, consulting fees, and long-term maintenance expenses.

  20. Enhancing Decision-Making in STSE Education by Inducing Reflection and Self-Regulated Learning

    NASA Astrophysics Data System (ADS)

    Gresch, Helge; Hasselhorn, Marcus; Bögeholz, Susanne

    2017-02-01

    Thoughtful decision-making to resolve socioscientific issues is central to science, technology, society, and environment (STSE) education. One approach for attaining this goal involves fostering students' decision-making processes. Thus, the present study explores whether the application of decision-making strategies, combined with reflections on the decision-making processes of others, enhances decision-making competence. In addition, this study examines whether this process is supported by elements of self-regulated learning, i.e., self-reflection regarding one's own performance and the setting of goals for subsequent tasks. A computer-based training program which involves the resolution of socioscientific issues related to sustainable development was developed in two versions: with and without elements of self-regulated learning. Its effects on decision-making competence were analyzed using a pre test-post test follow-up control-group design ( N = 242 high school students). Decision-making competence was assessed using an open-ended questionnaire that focused on three facets: consideration of advantages and disadvantages, metadecision aspects, and reflection on the decision-making processes of others. The findings suggest that students in both training groups incorporated aspects of metadecision into their statements more often than students in the control group. Furthermore, both training groups were more successful in reflecting on the decision-making processes of others. The students who received additional training in self-regulated learning showed greater benefits in terms of metadecision aspects and reflection, and these effects remained significant two months later. Overall, our findings demonstrate that the application of decision-making strategies, combined with reflections on the decision-making process and elements of self-regulated learning, is a fruitful approach in STSE education.

  1. Framing access to medicines in developing countries: an analysis of media coverage of Canada's Access to Medicines Regime.

    PubMed

    Esmail, Laura C; Phillips, Kaye; Kuek, Victoria; Cosio, Andrea Perez; Kohler, Jillian Clare

    2010-01-04

    In September 2003, the Canadian government committed to developing legislation that would facilitate greater access to affordable medicines for developing countries. Over the course of eight months, the legislation, now known as Canada's Access to Medicines Regime (CAMR), went through a controversial policy development process and the newspaper media was one of the major venues in which the policy debates took place. The purpose of this study was to examine how the media framed CAMR to determine how policy goals were conceptualized, which stakeholder interests controlled the public debate and how these variables related to the public policy process. We conducted a qualitative content analysis of newspaper coverage of the CAMR policy and implementation process from 2003-2008. The primary theoretical framework for this study was framing theory. A total of 90 articles from 11 Canadian newspapers were selected for inclusion in our analysis. A team of four researchers coded the articles for themes relating to access to medicines and which stakeholders' voice figured more prominently on each issue. Stakeholders examined included: the research-based industry, the generic industry, civil society, the Canadian government, and developing country representatives. The most frequently mentioned themes across all documents were the issues of drug affordability, intellectual property, trade agreements and obligations, and development. Issues such as human rights, pharmaceutical innovation, and economic competitiveness got little media representation. Civil society dominated the media contents, followed far behind by the Canadian government, the research-based and generic pharmaceutical industries. Developing country representatives were hardly represented in the media. Media framing obscured the discussion of some of the underlying policy goals in this case and failed to highlight issues which are now significant barriers to the use of the legislation. Using the media to engage the public in more in-depth exploration of the policy issues at stake may contribute to a more informed policy development process. The media can be an effective channel for those stakeholders with a weaker voice in policy deliberations to raise public attention to particular issues; however, the political and institutional context must be taken into account as it may outweigh media framing effects.

  2. Attentional selection in visual perception, memory and action: a quest for cross-domain integration

    PubMed Central

    Schneider, Werner X.; Einhäuser, Wolfgang; Horstmann, Gernot

    2013-01-01

    For decades, the cognitive and neural sciences have benefitted greatly from a separation of mind and brain into distinct functional domains. The tremendous success of this approach notwithstanding, it is self-evident that such a view is incomplete. Goal-directed behaviour of an organism requires the joint functioning of perception, memory and sensorimotor control. A prime candidate for achieving integration across these functional domains are attentional processes. Consequently, this Theme Issue brings together studies of attentional selection from many fields, both experimental and theoretical, that are united in their quest to find overreaching integrative principles of attention between perception, memory and action. In all domains, attention is understood as combination of competition and priority control (‘bias’), with the task as a decisive driving factor to ensure coherent goal-directed behaviour and cognition. Using vision as the predominant model system for attentional selection, many studies of this Theme Issue focus special emphasis on eye movements as a selection process that is both a fundamental action and serves a key function in perception. The Theme Issue spans a wide range of methods, from measuring human behaviour in the real word to recordings of single neurons in the non-human primate brain. We firmly believe that combining such a breadth in approaches is necessary not only for attentional selection, but also to take the next decisive step in all of the cognitive and neural sciences: to understand cognition and behaviour beyond isolated domains. PMID:24018715

  3. [Pursuit of economic efficiency in the hospital laboratory--full automatic re-test system of clinical chemistry, hematology, immunology and cost control system].

    PubMed

    Chiba, M

    2000-10-01

    Further business improvement is requested due to finance-based fluctuation and the influence of the revision in the medical treatment law. Therefore, new laboratories are needed. To achieving this in our hospital, economic efficiency is being pursued. The first issue is the use of space, the second issue is labor-saving. The third issue is the simplification of business procedures. There is individual quality control by the zonal verification method that we developed, as well as the quality control of the batch method using controlled substances. The four issue is cost control. By controlling the delivery and use of reagents and materials including the term of validity control, we made an effort to abolition defective stock. The fifth issue is correspondence to circulation style society. The disposal of laboratory garbage is a major issue. We controlled garbage that occurs unnecessarily. Furthermore, we are improving the demand for reagents that exceeds the specification and use reagent containers.

  4. Regulatory challenges in manufacturing of pancreatic islets.

    PubMed

    Linetsky, E; Ricordi, C

    2008-03-01

    At the present time, transplantation of pancreatic islet cells is considered an experimental therapy for a selected cohort of patients with type 1 diabetes, and is conducted under an Investigational New Drug (IND) application. Encouraging results of the Edmonton Protocol published in the year 2000 sparked a renewed interest in clinical transplantation of allogeneic islets, triggering a large number of IND applications for phase I clinical trials. Promising results reported by a number of centers since then prompted the Food and Drug Administration (FDA) to consider the possibility of licensing allogeneic islets as a therapeutic treatment for patients with type 1 diabetes. However, prior to licensure, issues such as safety, purity, efficacy, and potency of the islet product must be addressed. This is complicated by the intricate nature of pancreatic islets and limited characterization prior to transplantation. In this context, control of the manufacturing process plays a critical role in the definition of the final product. Despite significant progress made in standardization of the donor organ preservation methods, reagents used, and characterization assays performed to qualify an islet cell product, control of the isolation process remains a challenge. Within the scope of the FDA regulations, islet cells meet the definition of a biologic product, somatic cell therapy, and a drug. In addition, AABB standards that address cellular therapy products apply to manufacturing facilities accredited by this organization. Control of the source material, isolation process, and final product are critical issues that must be addressed in the context of FDA and other relevant regulations applicable to islet cell products.

  5. Prioritization of remedial actions for radioactive waste burials in the Chernobyl exclusion zone

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Crossland, Ian

    2013-07-01

    Large volumes of radioactive waste were urgently buried in the Chernobyl Exclusion Zone (ChEZ) in the aftermath of the 1986 accident. Twenty-six years later, decisions must be taken about whether and how to remediate these sites. An attempt to resolve two key issues is described here: 1. How to assess the hazards posed by these facilities, recognizing that, for the foreseeable future, the Chernobyl Exclusion Zone will remain under institutional control? and 2. What standards to apply in deciding the extent of remediation? This paper presents an examination of the issues and proposes a simple decision-making process. (authors)

  6. Whose Writing Is it Anyway?: Issues of Control in the Teaching of Writing

    ERIC Educational Resources Information Center

    Fisher, Ros

    2006-01-01

    In the UK, teachers have moved from a process approach to the teaching of writing to a more didactic and objectives led programme. This has given rise to concerns about the suppression of creativity and enjoyment. Writing is a convention bound activity where spelling, punctuation and expectations about different text types imply a right and wrong…

  7. Report to the Congress on the Strategic Defense Initiative, 1991

    DTIC Science & Technology

    1991-05-01

    ultraviolet, and infrared radiation-hardened charge-coupled device images , step-stare sensor signal processing algorithms , and processor...Demonstration Experiment (LODE) resolved central issues associated with wavefront sensing and control and the 4-meter I Large Advanced Mirror Program (LAMP...21 Figure 4-16 Firepond CO 2 Imaging Radar Demonstration .......................... 4-22 Figure 4-17 IBSS and the Shuttle

  8. A flexible CAMAC based data system for Space Shuttle scientific instruments

    NASA Technical Reports Server (NTRS)

    Ehrmann, C. H.; Baker, R. G.; Smith, R. L.; Kaminski, T. J.

    1979-01-01

    An effort has been made within NASA to produce a low-cost modular system for implementation of Shuttle payloads based on the CAMAC standards for packaging and data transfer. A key element of such a modular system is a means for controlling the data system, collecting and processing the data for transmission to the ground, and issuing commands to the instrument either from the ground or based on the data collected. A description is presented of such a means based on a network of digital processors and CAMAC crate controllers, which allows for the implementation of instruments ranging from those requiring only a single CAMAC crate of functional modules and no data processing to ones requiring multiple crates and multiple data processors.

  9. Understanding medical group financial and operational performance: the synergistic effect of linking statistical process control and profit and loss.

    PubMed

    Smolko, J R; Greisler, D S

    2001-01-01

    There is ongoing pressure for medical groups owned by not-for-profit health care systems or for-profit entrepreneurs to generate profit. The fading promise of superior strategy through health care integration has boards of directors clamoring for bottom-line performance. While prudent, sole focus on the bottom line through the lens of the profit-and-loss (P&L) statement provides incomplete information upon which to base executive decisions. The purpose of this paper is to suggest that placing statistical process control (SPC) charts in tandem with the P&L statement provides a more complete picture of medical group performance thereby optimizing decision making as executives deal with the whitewater issues surrounding physician practice ownership.

  10. A new approach of active compliance control via fuzzy logic control for multifingered robot hand

    NASA Astrophysics Data System (ADS)

    Jamil, M. F. A.; Jalani, J.; Ahmad, A.

    2016-07-01

    Safety is a vital issue in Human-Robot Interaction (HRI). In order to guarantee safety in HRI, a model reference impedance control can be a very useful approach introducing a compliant control. In particular, this paper establishes a fuzzy logic compliance control (i.e. active compliance control) to reduce impact and forces during physical interaction between humans/objects and robots. Exploiting a virtual mass-spring-damper system allows us to determine a desired compliant level by understanding the behavior of the model reference impedance control. The performance of fuzzy logic compliant control is tested in simulation for a robotic hand known as the RED Hand. The results show that the fuzzy logic is a feasible control approach, particularly to control position and to provide compliant control. In addition, the fuzzy logic control allows us to simplify the controller design process (i.e. avoid complex computation) when dealing with nonlinearities and uncertainties.

  11. Using Statistical Process Control for detecting anomalies in multivariate spatiotemporal Earth Observations

    NASA Astrophysics Data System (ADS)

    Flach, Milan; Mahecha, Miguel; Gans, Fabian; Rodner, Erik; Bodesheim, Paul; Guanche-Garcia, Yanira; Brenning, Alexander; Denzler, Joachim; Reichstein, Markus

    2016-04-01

    The number of available Earth observations (EOs) is currently substantially increasing. Detecting anomalous patterns in these multivariate time series is an important step in identifying changes in the underlying dynamical system. Likewise, data quality issues might result in anomalous multivariate data constellations and have to be identified before corrupting subsequent analyses. In industrial application a common strategy is to monitor production chains with several sensors coupled to some statistical process control (SPC) algorithm. The basic idea is to raise an alarm when these sensor data depict some anomalous pattern according to the SPC, i.e. the production chain is considered 'out of control'. In fact, the industrial applications are conceptually similar to the on-line monitoring of EOs. However, algorithms used in the context of SPC or process monitoring are rarely considered for supervising multivariate spatio-temporal Earth observations. The objective of this study is to exploit the potential and transferability of SPC concepts to Earth system applications. We compare a range of different algorithms typically applied by SPC systems and evaluate their capability to detect e.g. known extreme events in land surface processes. Specifically two main issues are addressed: (1) identifying the most suitable combination of data pre-processing and detection algorithm for a specific type of event and (2) analyzing the limits of the individual approaches with respect to the magnitude, spatio-temporal size of the event as well as the data's signal to noise ratio. Extensive artificial data sets that represent the typical properties of Earth observations are used in this study. Our results show that the majority of the algorithms used can be considered for the detection of multivariate spatiotemporal events and directly transferred to real Earth observation data as currently assembled in different projects at the European scale, e.g. http://baci-h2020.eu/index.php/ and http://earthsystemdatacube.net/. Known anomalies such as the Russian heatwave are detected as well as anomalies which are not detectable with univariate methods.

  12. Editorial

    NASA Astrophysics Data System (ADS)

    Goh, Gregory K. L.

    2014-06-01

    This special issue of the Journal of Solid State Chemistry is a peer-reviewed collection of papers presented at the 7th International Conference on Materials for Advanced Technologies (ICMAT2013), Symposium Q - Innovative processing of inorganic films and nanostructures of functional materials, organised by the Materials Research Society, Singapore and held at the Singapore International Convention & Exhibition Centre, Singapore, from 30 June to 5 July 2013. The symposium focused mainly on films, porous networks and nanostructures formed by innovative processing routes that reduce energy consumption, use new mediums, combine techniques or even innovative synthesis approaches. The understanding of film and nanostructure growth mechanisms and crystal shape control were also discussed. We acknowledge the invaluable contributions of all invited, oral and poster presenters. I also take this opportunity to thank reviewers from all over the world who kindly helped in reviewing the manuscripts and provided valuable comments, making the publication of this high quality issue possible.

  13. A Taxonomy on Accountability and Privacy Issues in Smart Grids

    NASA Astrophysics Data System (ADS)

    Naik, Ameya; Shahnasser, Hamid

    2017-07-01

    Cyber-Physical Systems (CPS) are combinations of computation, networking, and physical processes. Embedded computers and networks monitor control the physical processes, which affect computations and vice versa. Two applications of cyber physical systems include health-care and smart grid. In this paper, we have considered privacy aspects of cyber-physical system applicable to smart grid. Smart grid in collaboration with different stockholders can help in the improvement of power generation, communication, circulation and consumption. The proper management with monitoring feature by customers and utility of energy usage can be done through proper transmission and electricity flow; however cyber vulnerability could be increased due to an increased assimilation and linkage. This paper discusses various frameworks and architectures proposed for achieving accountability in smart grids by addressing privacy issues in Advance Metering Infrastructure (AMI). This paper also highlights additional work needed for accountability in more precise specifications such as uncertainty or ambiguity, indistinct, unmanageability, and undetectably.

  14. i-SAIRAS '90; Proceedings of the International Symposium on Artificial Intelligence, Robotics and Automation in Space, Kobe, Japan, Nov. 18-20, 1990

    NASA Technical Reports Server (NTRS)

    1990-01-01

    The present conference on artificial intelligence (AI), robotics, and automation in space encompasses robot systems, lunar and planetary robots, advanced processing, expert systems, knowledge bases, issues of operation and management, manipulator control, and on-orbit service. Specific issues addressed include fundamental research in AI at NASA, the FTS dexterous telerobot, a target-capture experiment by a free-flying robot, the NASA Planetary Rover Program, the Katydid system for compiling KEE applications to Ada, and speech recognition for robots. Also addressed are a knowledge base for real-time diagnosis, a pilot-in-the-loop simulation of an orbital docking maneuver, intelligent perturbation algorithms for space scheduling optimization, a fuzzy control method for a space manipulator system, hyperredundant manipulator applications, robotic servicing of EOS instruments, and a summary of astronaut inputs on automation and robotics for the Space Station Freedom.

  15. Software development environments: Status and trends

    NASA Technical Reports Server (NTRS)

    Duffel, Larry E.

    1988-01-01

    Currently software engineers are the essential integrating factors tying several components together. The components consist of process, methods, computers, tools, support environments, and software engineers. The engineers today empower the tools versus the tools empowering the engineers. Some of the issues in software engineering are quality, managing the software engineering process, and productivity. A strategy to accomplish this is to promote the evolution of software engineering from an ad hoc, labor intensive activity to a managed, technology supported discipline. This strategy may be implemented by putting the process under management control, adopting appropriate methods, inserting the technology that provides automated support for the process and methods, collecting automated tools into an integrated environment and educating the personnel.

  16. Droplet digital polymerase chain reaction (ddPCR) assays integrated with an internal control for quantification of bovine, porcine, chicken and turkey species in food and feed

    PubMed Central

    Shehata, Hanan R.; Li, Jiping; Redda, Helen; Cheng, Shumei; Tabujara, Nicole; Li, Honghong; Warriner, Keith; Hanner, Robert

    2017-01-01

    Food adulteration and feed contamination are significant issues in the food/feed industry, especially for meat products. Reliable techniques are needed to monitor these issues. Droplet Digital PCR (ddPCR) assays were developed and evaluated for detection and quantification of bovine, porcine, chicken and turkey DNA in food and feed samples. The ddPCR methods were designed based on mitochondrial DNA sequences and integrated with an artificial recombinant plasmid DNA to control variabilities in PCR procedures. The specificity of the ddPCR assays was confirmed by testing both target species and additional 18 non-target species. Linear regression established a detection range between 79 and 33200 copies of the target molecule from 0.26 to 176 pg of fresh animal tissue DNA with a coefficient of determination (R2) of 0.997–0.999. The quantification ranges of the methods for testing fortified heat-processed food and feed samples were 0.05–3.0% (wt/wt) for the bovine and turkey targets, and 0.01–1.0% (wt/wt) for pork and chicken targets. Our methods demonstrated acceptable repeatability and reproducibility for the analytical process for food and feed samples. Internal validation of the PCR process was monitored using a control chart for 74 consecutive ddPCR runs for quantifying bovine DNA. A matrix effect was observed while establishing calibration curves with the matrix type under testing, and the inclusion of an internal control in DNA extraction provides a useful means to overcome this effect. DNA degradation caused by heating, sonication or Taq I restriction enzyme digestion was found to reduce ddPCR readings by as much as 4.5 fold. The results illustrated the applicability of the methods to quantify meat species in food and feed samples without the need for a standard curve, and to potentially support enforcement activities for food authentication and feed control. Standard reference materials matching typical manufacturing processes are needed for future validation of ddPCR assays for absolute quantification of meat species. PMID:28796824

  17. Droplet digital polymerase chain reaction (ddPCR) assays integrated with an internal control for quantification of bovine, porcine, chicken and turkey species in food and feed.

    PubMed

    Shehata, Hanan R; Li, Jiping; Chen, Shu; Redda, Helen; Cheng, Shumei; Tabujara, Nicole; Li, Honghong; Warriner, Keith; Hanner, Robert

    2017-01-01

    Food adulteration and feed contamination are significant issues in the food/feed industry, especially for meat products. Reliable techniques are needed to monitor these issues. Droplet Digital PCR (ddPCR) assays were developed and evaluated for detection and quantification of bovine, porcine, chicken and turkey DNA in food and feed samples. The ddPCR methods were designed based on mitochondrial DNA sequences and integrated with an artificial recombinant plasmid DNA to control variabilities in PCR procedures. The specificity of the ddPCR assays was confirmed by testing both target species and additional 18 non-target species. Linear regression established a detection range between 79 and 33200 copies of the target molecule from 0.26 to 176 pg of fresh animal tissue DNA with a coefficient of determination (R2) of 0.997-0.999. The quantification ranges of the methods for testing fortified heat-processed food and feed samples were 0.05-3.0% (wt/wt) for the bovine and turkey targets, and 0.01-1.0% (wt/wt) for pork and chicken targets. Our methods demonstrated acceptable repeatability and reproducibility for the analytical process for food and feed samples. Internal validation of the PCR process was monitored using a control chart for 74 consecutive ddPCR runs for quantifying bovine DNA. A matrix effect was observed while establishing calibration curves with the matrix type under testing, and the inclusion of an internal control in DNA extraction provides a useful means to overcome this effect. DNA degradation caused by heating, sonication or Taq I restriction enzyme digestion was found to reduce ddPCR readings by as much as 4.5 fold. The results illustrated the applicability of the methods to quantify meat species in food and feed samples without the need for a standard curve, and to potentially support enforcement activities for food authentication and feed control. Standard reference materials matching typical manufacturing processes are needed for future validation of ddPCR assays for absolute quantification of meat species.

  18. Integrating end-to-end threads of control into object-oriented analysis and design

    NASA Technical Reports Server (NTRS)

    Mccandlish, Janet E.; Macdonald, James R.; Graves, Sara J.

    1993-01-01

    Current object-oriented analysis and design methodologies fall short in their use of mechanisms for identifying threads of control for the system being developed. The scenarios which typically describe a system are more global than looking at the individual objects and representing their behavior. Unlike conventional methodologies that use data flow and process-dependency diagrams, object-oriented methodologies do not provide a model for representing these global threads end-to-end. Tracing through threads of control is key to ensuring that a system is complete and timing constraints are addressed. The existence of multiple threads of control in a system necessitates a partitioning of the system into processes. This paper describes the application and representation of end-to-end threads of control to the object-oriented analysis and design process using object-oriented constructs. The issue of representation is viewed as a grouping problem, that is, how to group classes/objects at a higher level of abstraction so that the system may be viewed as a whole with both classes/objects and their associated dynamic behavior. Existing object-oriented development methodology techniques are extended by adding design-level constructs termed logical composite classes and process composite classes. Logical composite classes are design-level classes which group classes/objects both logically and by thread of control information. Process composite classes further refine the logical composite class groupings by using process partitioning criteria to produce optimum concurrent execution results. The goal of these design-level constructs is to ultimately provide the basis for a mechanism that can support the creation of process composite classes in an automated way. Using an automated mechanism makes it easier to partition a system into concurrently executing elements that can be run in parallel on multiple processors.

  19. Motor control and the management of musculoskeletal dysfunction.

    PubMed

    van Vliet, Paulette M; Heneghan, Nicola R

    2006-08-01

    This paper aims to develop understanding of three important motor control issues--feedforward mechanisms, cortical plasticity and task-specificity and assess the implications for musculoskeletal practice. A model of control for the reach-to-grasp movement illustrates how the central nervous system integrates sensorimotor processes to control complex movements. Feedforward mechanisms, an essential element of motor control, are altered in neurologically intact patients with chronic neck pain and low back pain. In healthy subjects, cortical mapping studies using transcranial magnetic stimulation have demonstrated that neural pathways adapt according to what and how much is practised. Neuroplasticity has also been demonstrated in a number of musculoskeletal conditions, where cortical maps are altered compared to normal. Behavioural and neurophysiological studies indicate that environmental and task constraints such as the goal of the task and an object's shape and size, are determinants of the motor schema for reaching and other movements. Consideration of motor control issues as well as signs and symptoms, may facilitate management of musculoskeletal conditions and improve outcome. Practice of entire everyday tasks at an early stage and systematic variation of the task is recommended. Training should be directed with the aim of re-educating feedforward mechanisms where necessary and the amount of practice should be sufficient to cause changes in cortical activity.

  20. Personnel controlling system principles and structural goals of the industrial companies

    NASA Astrophysics Data System (ADS)

    Pimenova, Anna; Kuzmina, Svetlana; Zavialov, Kirill; Ushakova, Elena

    2017-10-01

    This article peruses the basics of the controlling system, its functions and structural phases of the industrial companies. The personnel controlling of the industrial companies (for examples transportation or energy company) is examined in detail. Controlling system occurs applicable within various activity fields of an enterprise. Modern approaches of the domestic scholars are inspected. Goals and focuses of the personnel controlling system of the industrial companies have been analyzed. Foremost it occurs crucial to analyze and define the entire labor process to figure out primary requirements issued to the labor and employees. In article is offered the road map to follow to structure the purposes of all management system of personnel in the specific organization - in the transportation or energy company or other enterprises.

  1. Human vs autonomous control of planetary roving vehicles

    NASA Technical Reports Server (NTRS)

    Whitney, W. M.

    1974-01-01

    Supervisory or semiautonomous control has some compelling advantages over step-by-step human command and verification for the operation of roving vehicles on remote planetary surfaces. There are also disadvantages in relation to the complex system that must be mobilized and the chain of events that must be enacted to conduct a mission. Which of the two control methods is better on technical grounds may not be the deciding factor in its acceptance or rejection. Some of the issues that affect changes in spacecraft design and operation are summarized. To accelerate the movement toward more autonomous machines, it will be necessary to understand and to address the problems that such autonomy will create for other elements of the control system and for the control process.

  2. Control of Prosthetic Hands via the Peripheral Nervous System

    PubMed Central

    Ciancio, Anna Lisa; Cordella, Francesca; Barone, Roberto; Romeo, Rocco Antonio; Bellingegni, Alberto Dellacasa; Sacchetti, Rinaldo; Davalli, Angelo; Di Pino, Giovanni; Ranieri, Federico; Di Lazzaro, Vincenzo; Guglielmelli, Eugenio; Zollo, Loredana

    2016-01-01

    This paper intends to provide a critical review of the literature on the technological issues on control and sensorization of hand prostheses interfacing with the Peripheral Nervous System (i.e., PNS), and their experimental validation on amputees. The study opens with an in-depth analysis of control solutions and sensorization features of research and commercially available prosthetic hands. Pros and cons of adopted technologies, signal processing techniques and motion control solutions are investigated. Special emphasis is then dedicated to the recent studies on the restoration of tactile perception in amputees through neural interfaces. The paper finally proposes a number of suggestions for designing the prosthetic system able to re-establish a bidirectional communication with the PNS and foster the prosthesis natural control. PMID:27092041

  3. Mitochondrial metals as a potential therapeutic target in neurodegeneration

    PubMed Central

    Grubman, A; White, A R; Liddell, J R

    2014-01-01

    Transition metals are critical for enzyme function and protein folding, but in excess can mediate neurotoxic oxidative processes. As mitochondria are particularly vulnerable to oxidative damage due to radicals generated during ATP production, mitochondrial biometal homeostasis must therefore be tightly controlled to safely harness the redox potential of metal enzyme cofactors. Dysregulation of metal functions is evident in numerous neurological disorders including Alzheimer's disease, stroke, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis and Friedrich's ataxia. This review describes the mitochondrial metal defects in these disorders and highlights novel metal-based therapeutic approaches that target mitochondrial metal homeostasis in neurological disorders. Linked Articles This article is part of a themed issue on Mitochondrial Pharmacology: Energy, Injury & Beyond. To view the other articles in this issue visit http://dx.doi.org/10.1111/bph.2014.171.issue-8 PMID:24206195

  4. Examining the interaction between cognitive control and reward sensitivity in substance use dependence.

    PubMed

    Charles-Walsh, Kathleen; Upton, Daniel J; Hester, Robert

    2016-09-01

    Drug dependence is characterized by altered reward processing and poor cognitive control, expressed as a preference for immediate rewards and impaired inhibitory control, respectively. To examine the interaction between reward processing (via the presence or absence of reward) and mechanisms of inhibitory control in drug dependence, the current study used the Monetary Incentive Control Task (MICT) to examine whether a group of opiate dependent persons demonstrated greater difficulty exerting control over immediate rewards compared to neutral stimuli. The MICT is a Go/Stop paradigm that examines inhibitory control over immediate rewards. Performance of 32 opiate dependent individuals was compared to 29 healthy controls. Opiate users demonstrated poorer inhibitory performance than controls, irrespective of cues signaling immediate reward. Whereas control participants' responses were modulated by probability cues, the opiate group did not show a capacity to up-regulate their cognitive control performance. The present results suggest a general decrease in cognitive control in opiate dependence, accompanied by a reduced ability to optimally modulate behavior in accordance with external cues. Opiate users and controls did not differ in the interaction between cognitive control and reward. The study highlights important issues for future research to consider when further examining this interaction in drug dependence. Crown Copyright © 2016. Published by Elsevier Ireland Ltd. All rights reserved.

  5. Computer software configuration description, 241-AY and 241-AZ tank farm MICON automation system

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Winkelman, W.D.

    This document describes the configuration process, choices and conventions used during the configuration activities, and issues involved in making changes to the configuration. Includes the master listings of the Tag definitions, which should be revised to authorize any changes. Revision 2 incorporates minor changes to ensure the document setpoints accurately reflect limits (including exhaust stack flow of 800 scfm) established in OSD-T-151-00019. The MICON DCS software controls and monitors the instrumentation and equipment associated with plant systems and processes.

  6. Requirements and Usage of NVM in Advanced Onboard Data Processing Systems

    NASA Technical Reports Server (NTRS)

    Some, R.

    2001-01-01

    This viewgraph presentation gives an overview of the requirements and uses of non-volatile memory (NVM) in advanced onboard data processing systems. Supercomputing in space presents the only viable approach to the bandwidth problem (can't get data down to Earth), controlling constellations of cooperating satellites, reducing mission operating costs, and real-time intelligent decision making and science data gathering. Details are given on the REE vision and impact on NASA and Department of Defense missions, objectives of REE, baseline architecture, and issues. NVM uses and requirements are listed.

  7. Controlled confinement of DNA at the nanoscale: nanofabrication and surface bio-functionalization

    PubMed Central

    Palma, Matteo; Abramson, Justin; Gorodetsky, Alon; Nuckolls, Colin; Sheetz, Michael P.; Wind, Shalom J.; Hone, James

    2012-01-01

    Nanopatterned arrays of biomolecules are a powerful tool to address fundamental issues in many areas of biology. DNA nanoarrays, in particular, are of interest in the study of both DNA-protein interactions as well as for biodiagnostic investigations. In this context, achieving a highly specific nanoscale assembly of oligonulceotides at surfaces is critical. In this chapter we describe a method to control the immobilization of DNA on nanopatterned surfaces: the nanofabrication and the bio-functionalization involved in the process will be discussed. PMID:21674372

  8. Resolution No. 598-87, Regulations for the Functioning of the Land Tenure Registry, 27 October 1987.

    PubMed

    1988-01-01

    This Resolution sets forth Regulations for the Land Tenancy Registry of Cuba. It provides that the Registry is part of a scheme for exercising control over legal land tenure and has the following objectives: maintaining control of national land; determining the legal situation of holders of land; recognizing the number of legal holders of land; furnishing information on acquisition, exploitation, and buildings; issuing certificates; and analyzing and processing records in appeals. Further provisions of the Resolution lay down details about these functions. full text

  9. Physical Processes Controlling Earth's Climate

    NASA Technical Reports Server (NTRS)

    Genio, Anthony Del

    2013-01-01

    As background for consideration of the climates of the other terrestrial planets in our solar system and the potential habitability of rocky exoplanets, we discuss the basic physics that controls the Earths present climate, with particular emphasis on the energy and water cycles. We define several dimensionless parameters relevant to characterizing a planets general circulation, climate and hydrological cycle. We also consider issues associated with the use of past climate variations as indicators of future anthropogenically forced climate change, and recent advances in understanding projections of future climate that might have implications for Earth-like exoplanets.

  10. Corral framework: Trustworthy and fully functional data intensive parallel astronomical pipelines

    NASA Astrophysics Data System (ADS)

    Cabral, J. B.; Sánchez, B.; Beroiz, M.; Domínguez, M.; Lares, M.; Gurovich, S.; Granitto, P.

    2017-07-01

    Data processing pipelines represent an important slice of the astronomical software library that include chains of processes that transform raw data into valuable information via data reduction and analysis. In this work we present Corral, a Python framework for astronomical pipeline generation. Corral features a Model-View-Controller design pattern on top of an SQL Relational Database capable of handling: custom data models; processing stages; and communication alerts, and also provides automatic quality and structural metrics based on unit testing. The Model-View-Controller provides concept separation between the user logic and the data models, delivering at the same time multi-processing and distributed computing capabilities. Corral represents an improvement over commonly found data processing pipelines in astronomysince the design pattern eases the programmer from dealing with processing flow and parallelization issues, allowing them to focus on the specific algorithms needed for the successive data transformations and at the same time provides a broad measure of quality over the created pipeline. Corral and working examples of pipelines that use it are available to the community at https://github.com/toros-astro.

  11. Simulations of Control Schemes for Inductively Coupled Plasma Sources

    NASA Astrophysics Data System (ADS)

    Ventzek, P. L. G.; Oda, A.; Shon, J. W.; Vitello, P.

    1997-10-01

    Process control issues are becoming increasingly important in plasma etching. Numerical experiments are an excellent test-bench for evaluating a proposed control system. Models are generally reliable enough to provide information about controller robustness, fitness of diagnostics. We will present results from a two dimensional plasma transport code with a multi-species plasma chemstry obtained from a global model. [1-2] We will show a correlation of external etch parameters (e.g. input power) with internal plasma parameters (e.g. species fluxes) which in turn are correlated with etch results (etch rate, uniformity, and selectivity) either by comparison to experiment or by using a phenomenological etch model. After process characterization, a control scheme can be evaluated since the relationship between the variable to be controlled (e.g. uniformity) is related to the measurable variable (e.g. a density) and external parameter (e.g. coil current). We will present an evaluation using the HBr-Cl2 system as an example. [1] E. Meeks and J. W. Shon, IEEE Trans. on Plasma Sci., 23, 539, 1995. [2] P. Vitello, et al., IEEE Trans. on Plasma Sci., 24, 123, 1996.

  12. Characterization of integrated optical CD for process control

    NASA Astrophysics Data System (ADS)

    Yu, Jackie; Uchida, Junichi; van Dommelen, Youri; Carpaij, Rene; Cheng, Shaunee; Pollentier, Ivan; Viswanathan, Anita; Lane, Lawrence; Barry, Kelly A.; Jakatdar, Nickhil

    2004-05-01

    The accurate measurement of CD (critical dimension) and its application to inline process control are key challenges for high yield and OEE (overall equipment efficiency) in semiconductor production. CD-SEM metrology, although providing the resolution necessary for CD evaluation, suffers from the well-known effect of resist shrinkage, making accuracy and stability of the measurements an issue. For sub-100 nm in-line process control, where accuracy and stability as well as speed are required, CD-SEM metrology faces serious limitations. In contrast, scatterometry, using broadband optical spectra taken from grating structures, does not suffer from such limitations. This technology is non-destructive and, in addition to CD, provides profile information and film thickness in a single measurement. Using Timbre's Optical Digital Profililometry (ODP) technology, we characterized the Process Window, using a iODP101 integrated optical CD metrology into a TEL Clean Track at IMEC. We demonstrate the Optical CD's high sensitivity to process change and its insensitivity to measurement noise. We demonstrate the validity of ODP modeling by showing its accurate response to known process changes built into the evaluation and its excellent correlation to CD-SEM. We will further discuss the intrinsic Optical CD metrology factors that affect the tool precision, accuracy and its correlation to CD-SEM.

  13. The Asilomar Survey: Stakeholders' Opinions on Ethical Issues Related to Brain-Computer Interfacing.

    PubMed

    Nijboer, Femke; Clausen, Jens; Allison, Brendan Z; Haselager, Pim

    2013-01-01

    Brain-Computer Interface (BCI) research and (future) applications raise important ethical issues that need to be addressed to promote societal acceptance and adequate policies. Here we report on a survey we conducted among 145 BCI researchers at the 4 th International BCI conference, which took place in May-June 2010 in Asilomar, California. We assessed respondents' opinions about a number of topics. First, we investigated preferences for terminology and definitions relating to BCIs. Second, we assessed respondents' expectations on the marketability of different BCI applications (BCIs for healthy people, BCIs for assistive technology, BCIs-controlled neuroprostheses and BCIs as therapy tools). Third, we investigated opinions about ethical issues related to BCI research for the development of assistive technology: informed consent process with locked-in patients, risk-benefit analyses, team responsibility, consequences of BCI on patients' and families' lives, liability and personal identity and interaction with the media. Finally, we asked respondents which issues are urgent in BCI research.

  14. Controllability analysis and decentralized control of a wet limestone flue gas desulfurization plant

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Perales, A.L.V.; Ortiz, F.J.G.; Ollero, P.

    2008-12-15

    Presently, decentralized feedback control is the only control strategy used in wet limestone flue gas desulfurization (WLFGD) plants. Proper tuning of this control strategy is becoming an important issue in WLFGD plants because more stringent SO{sub 2} regulations have come into force recently. Controllability analysis is a highly valuable tool for proper design of control systems, but it has not been applied to WLFGD plants so far. In this paper a decentralized control strategy is designed and applied to a WLFGD pilot plant taking into account the conclusions of a controllability analysis. The results reveal that good SO{sub 2} controlmore » in WLFGD plants can be achieved mainly because the main disturbance of the process is well-aligned with the plant and interactions between control loops are beneficial to SO{sub 2} control.« less

  15. Choosing a Control Group in Effectiveness Trials of Behavioral Drug Abuse Treatments

    PubMed Central

    Brigham, Gregory S.; Feaster, Daniel J.; Wakim, Paul G.; Dempsey, Catherine L.

    2009-01-01

    Effectiveness trials are an important step in the scientific process of developing and evaluating behavioral treatments. The focus on effectiveness research presents a different set of requirements on the research design when compared with efficacy studies. The choice of a control condition has many implications for a clinical trial's internal and external validity. The purpose of this manuscript is to provide a discussion of the issues involved in choosing a control group for effectiveness trials of behavioral interventions in substance abuse treatment. The authors provide a description of four trial designs and a discussion of the advantages and disadvantages of each. PMID:19553062

  16. [Application of bioassay in quality control of Chinese materia medica-taking Radix Isatidis as an example].

    PubMed

    Yan, Dan; Ren, Yongshen; Luo, Jiaoyang; Li, Hanbing; Feng, Xue; Xiao, Xiaohe

    2010-10-01

    Bioassay, which construct the characteristics consistents with Chinese medical science, is the core mode and methods for the quality control of Chinese materia medica. Taking the bioassay of Radix Isatidis as an example, the contribution, status and application of bioassay in the quality control of Chinese materia medica were introduced in this article, and two key issue (the selection of reference and measurement methods) in the process of establishing bioassay were also explained. This article expects to provide a reference for the development and improvement of the bioassay of Chinese materia medica in a practical manipulation level.

  17. Temporal Dynamic Controllability Revisited

    NASA Technical Reports Server (NTRS)

    Morris, Paul H.; Muscettola, Nicola

    2005-01-01

    An important issue for temporal planners is the ability to handle temporal uncertainty. We revisit the question of how to determine whether a given set of temporal requirements are feasible in the light of uncertain durations of some processes. In particular, we consider how best to determine whether a network is Dynamically Controllable, i.e., whether a dynamic strategy exists for executing the network that is guaranteed to satisfy the requirements. Previous work has shown the existence of a pseudo-polynomial algorithm for testing Dynamic Controllability. Here, we greatly simplify the previous framework, and present a true polynomial algorithm with a cutoff based only on the number of nodes.

  18. Improved process robustness by using closed loop control in deep drawing applications

    NASA Astrophysics Data System (ADS)

    Barthau, M.; Liewald, M.; Christian, Held

    2017-09-01

    The production of irregular shaped deep-drawing parts with high quality requirements, which are common in today’s automotive production, permanently challenges production processes. High requirements on lightweight construction of passenger car bodies following European regulations until 2020 have been massively increasing the use of high strength steels substantially for years and are also leading to bigger challenges in sheet metal part production. Of course, the more and more complex shapes of today’s car body shells also intensify the issue due to modern and future design criteria. The metal forming technology tries to meet these challenges by developing a highly sophisticated layout of deep drawing dies that consider part quality requirements, process robustness and controlled material flow during the deep or stretch drawing process phase. A new method for controlling material flow using a closed loop system was developed at the IFU Stuttgart. In contrast to previous approaches, this new method allows a control intervention during the deep-drawing stroke. The blank holder force around the outline of the drawn part is used as control variable. The closed loop is designed as trajectory follow up with feed forward control. The used command variable is the part-wall stress that is measured with a piezo-electric measuring pin. In this paper the used control loop will be described in detail. The experimental tool that was built for testing the new control approach is explained here with its features. A method for gaining the follow up trajectories from simulation will also be presented. Furthermore, experimental results considering the robustness of the deep drawing process and the gain in process performance with developed control loop will be shown. Finally, a new procedure for the industrial application of the new control method of deep drawing will be presented by using a new kind of active element to influence the local blank holder pressure onto part flange.

  19. WE-H-BRC-04: Implement Lean Methodology to Make Our Current Process of CT Simulation to Treatment More Efficient

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Boddu, S; Morrow, A; Krishnamurthy, N

    Purpose: Our goal is to implement lean methodology to make our current process of CT simulation to treatment more efficient. Methods: In this study, we implemented lean methodology and tools and employed flowchart in excel for process-mapping. We formed a group of physicians, physicists, dosimetrists, therapists and a clinical physics assistant and huddled bi-weekly to map current value streams. We performed GEMBA walks and observed current processes from scheduling patient CT Simulations to treatment plan approval. From this, the entire workflow was categorized into processes, sub-processes, and tasks. For each process we gathered data on touch time, first time quality,more » undesirable effects (UDEs), and wait-times from relevant members of each task. UDEs were binned per frequency of their occurrence. We huddled to map future state and to find solutions to high frequency UDEs. We implemented visual controls, hard stops, and documented issues found during chart checks prior to treatment plan approval. Results: We have identified approximately 64 UDEs in our current workflow that could cause delays, re-work, compromise the quality and safety of patient treatments, or cause wait times between 1 – 6 days. While some UDEs are unavoidable, such as re-planning due to patient weight loss, eliminating avoidable UDEs is our goal. In 2015, we found 399 issues with patient treatment plans, of which 261, 95 and 43 were low, medium and high severity, respectively. We also mapped patient-specific QA processes for IMRT/Rapid Arc and SRS/SBRT, involving 10 and 18 steps, respectively. From these, 13 UDEs were found and 5 were addressed that solved 20% of issues. Conclusion: We have successfully implemented lean methodology and tools. We are further mapping treatment site specific workflows to identify bottlenecks, potential breakdowns and personnel allocation and employ tools like failure mode effects analysis to mitigate risk factors to make this process efficient.« less

  20. Transient performance analysis of the master cylinder hydraulic system of a 6.3 MN fineblanking press

    NASA Astrophysics Data System (ADS)

    Yi, Guodong; Li, Jin

    2018-03-01

    The master cylinder hydraulic system is the core component of the fineblanking press that seriously affects the machine performance. A key issue in the design of the master cylinder hydraulic system is dealing with the heavy shock loads in the fineblanking process. In this paper, an equivalent model of the master cylinder hydraulic system is established based on typical process parameters for practical fineblanking; then, the response characteristics of the master cylinder slider to the step changes in the load and control current are analyzed, and lastly, control strategies for the proportional valve are studied based on the impact of the control parameters on the kinetic stability of the slider. The results show that the kinetic stability of the slider is significantly affected by the step change of the control current, while it is slightly affected by the step change of the system load, which can be improved by adjusting the flow rate and opening time of the proportional valve.

  1. Remotely controlled fusion of selected vesicles and living cells: a key issue review

    NASA Astrophysics Data System (ADS)

    Bahadori, Azra; Moreno-Pescador, Guillermo; Oddershede, Lene B.; Bendix, Poul M.

    2018-03-01

    Remote control over fusion of single cells and vesicles has a great potential in biological and chemical research allowing both transfer of genetic material between cells and transfer of molecular content between vesicles. Membrane fusion is a critical process in biology that facilitates molecular transport and mixing of cellular cytoplasms with potential formation of hybrid cells. Cells precisely regulate internal membrane fusions with the aid of specialized fusion complexes that physically provide the energy necessary for mediating fusion. Physical factors like membrane curvature, tension and temperature, affect biological membrane fusion by lowering the associated energy barrier. This has inspired the development of physical approaches to harness the fusion process at a single cell level by using remotely controlled electromagnetic fields to trigger membrane fusion. Here, we critically review various approaches, based on lasers or electric pulses, to control fusion between individual cells or between individual lipid vesicles and discuss their potential and limitations for present and future applications within biochemistry, biology and soft matter.

  2. Robust decentralized control laws for the ACES structure

    NASA Technical Reports Server (NTRS)

    Collins, Emmanuel G., Jr.; Phillips, Douglas J.; Hyland, David C.

    1991-01-01

    Control system design for the Active Control Technique Evaluation for Spacecraft (ACES) structure at NASA Marshall Space Flight Center is discussed. The primary objective of this experiment is to design controllers that provide substantial reduction of the line-of-sight pointing errors. Satisfaction of this objective requires the controllers to attenuate beam vibration significantly. The primary method chosen for control design is the optimal projection approach for uncertain systems (OPUS). The OPUS design process allows the simultaneous tradeoff of five fundamental issues in control design: actuator sizing, sensor accuracy, controller order, robustness, and system performance. A brief description of the basic ACES configuration is given. The development of the models used for control design and control design for eight system loops that were selected by analysis of test data collected from the structure are discussed. Experimental results showing that very significant performance improvement is achieved when all eight feedback loops are closed are presented.

  3. Emotions and memory in borderline personality disorder.

    PubMed

    Winter, Dorina; Elzinga, Bernet; Schmahl, Christian

    2014-01-01

    Memory processes such as encoding, storage, and retrieval of information are influenced by emotional content. Because patients with borderline personality disorder (BPD) are particularly susceptible to emotional information, it is relevant to understand whether such memory processes are altered in this patient group. This systematic literature review collects current evidence on this issue. Research suggests that emotional information interferes more strongly with information processing and learning in BPD patients than in healthy controls. In general, BPD patients do not seem to differ from healthy control subjects in their ability to memorize emotional information, but they tend to have specific difficulties forgetting negative information. Also, BPD patients seem to recall autobiographical, particularly negative events with stronger arousal than healthy controls, while BPD patients also show specific temporo-prefrontal alterations in neural correlates. No substantial evidence was found that the current affective state influences learning and memory in BPD patients any differently than in healthy control subjects. In general, a depressive mood seems to both deteriorate and negatively bias information processing and memories, while there is evidence that dissociative symptoms impair learning and memory independently of stimulus valence. This review discusses methodological challenges of studies on memory and emotions in BPD and makes suggestions for future research and clinical implications. © 2013 S. Karger AG, Basel.

  4. Resolving critical dimension drift over time in plasma etching through virtual metrology based wafer-to-wafer control

    NASA Astrophysics Data System (ADS)

    Lee, Ho Ki; Baek, Kye Hyun; Shin, Kyoungsub

    2017-06-01

    As semiconductor devices are scaled down to sub-20 nm, process window of plasma etching gets extremely small so that process drift or shift becomes more significant. This study addresses one of typical process drift issues caused by consumable parts erosion over time and provides feasible solution by using virtual metrology (VM) based wafer-to-wafer control. Since erosion of a shower head has center-to-edge area dependency, critical dimensions (CDs) at the wafer center and edge area get reversed over time. That CD trend is successfully estimated on a wafer-to-wafer basis by a partial least square (PLS) model which combines variables from optical emission spectroscopy (OES), VI-probe and equipment state gauges. R 2 of the PLS model reaches 0.89 and its prediction performance is confirmed in a mass production line. As a result, the model can be exploited as a VM for wafer-to-wafer control. With the VM, advanced process control (APC) strategy is implemented to solve the CD drift. Three σ of CD across wafer is improved from the range (1.3-2.9 nm) to the range (0.79-1.7 nm). Hopefully, results introduced in this paper will contribute to accelerating implementation of VM based APC strategy in semiconductor industry.

  5. Transnational organizing: Issue professionals in environmental sustainability networks.

    PubMed

    Henriksen, Lasse Folke; Seabrooke, Leonard

    2016-09-01

    An ongoing question for institutional theory is how organizing occurs transnationally, where institution building occurs in a highly ambiguous environment. This article suggests that at the core of transnational organizing is competition and coordination within professional and organizational networks over who controls issues. Transnational issues are commonly organized through professional battles over how issues are treated and what tasks are involved. These professional struggles are often more important than what organization has a formal mandate over an issue. We highlight how 'issue professionals' operate in two-level professional and organizational networks to control issues. This two-level network provides the context for action in which professionals do their institutional work. The two-level network carries information about professional incentives and also norms about how issues should be treated and governed by organizations. Using network and career sequences methods, we provide a case of transnational organizing through professionals who attempt issue control and network management on transnational environmental sustainability certification. The article questions how transnational organizing happens, and how we can best identify attempts at issue control.

  6. Transnational organizing: Issue professionals in environmental sustainability networks

    PubMed Central

    Henriksen, Lasse Folke; Seabrooke, Leonard

    2015-01-01

    An ongoing question for institutional theory is how organizing occurs transnationally, where institution building occurs in a highly ambiguous environment. This article suggests that at the core of transnational organizing is competition and coordination within professional and organizational networks over who controls issues. Transnational issues are commonly organized through professional battles over how issues are treated and what tasks are involved. These professional struggles are often more important than what organization has a formal mandate over an issue. We highlight how ‘issue professionals’ operate in two-level professional and organizational networks to control issues. This two-level network provides the context for action in which professionals do their institutional work. The two-level network carries information about professional incentives and also norms about how issues should be treated and governed by organizations. Using network and career sequences methods, we provide a case of transnational organizing through professionals who attempt issue control and network management on transnational environmental sustainability certification. The article questions how transnational organizing happens, and how we can best identify attempts at issue control. PMID:28490973

  7. AHPCRC (Army High Performance Computing Research Center) Bulletin. Volume 3, Issue 1

    DTIC Science & Technology

    2011-01-01

    release; distribution is unlimited. Multiscale Modeling of Materials The rotating reflector antenna associated with airport traffic control systems is...batteries and phased-array antennas . Power and efficiency studies evaluate on-board HPC systems and advanced image processing applications. 2010 marked...giving way in some applications to a newer technology called the phased array antenna system (sometimes called a beamformer, example shown at right

  8. Space Shuttle Reusable Solid Rocket Motor

    NASA Technical Reports Server (NTRS)

    Moore, Dennis; Phelps, Jack; Perkins, Fred

    2010-01-01

    RSRM is a highly reliable human-rated Solid Rocket Motor: a) Largest diameter SRM to achieve flight status; b) Only human-rated SRM. RSRM reliability achieved by: a)Applying special attention to Process Control, Testing, and Postflight; b) Communicating often; c) Identifying and addressing issues in a disciplined approach; d) Identifying and fully dispositioning "out-of-family" conditions; e) Addressing minority opinions; and f) Learning our lessons.

  9. Risk/Requirements Trade-off Guidelines for Low Cost Satellite Systems

    NASA Technical Reports Server (NTRS)

    Cornford, Steven L.; Man, Kin F.

    1996-01-01

    The accelerating trend toward faster, better, cheaper missions places increasing emphasis on the trade-offs between requirements and risk to reduce cost and development times, while still improving quality and reliability. The Risk/Requirement Trade-off Guidelines discussed in this paper are part of an integrated approach to address the main issues by focusing on the sum of prevention, analysis, control, or test (PACT) processes.

  10. Russian Political, Economic, and Security Issues and U.S. Interests

    DTIC Science & Technology

    2007-01-18

    polonium 210 from Moscow, through Germany, to London, apparently carried by one of the Russians Litvinenko met November 1. Russian authorities deny...radio under tight state control and virtually eliminated effective political opposition. Federal forces have suppressed large-scale military resistance...Russia’s needs — food and food processing, oil and gas extraction technology, computers, communications, transportation, and investment capital — are

  11. Controllable uncertain opinion diffusion under confidence bound and unpredicted diffusion probability

    NASA Astrophysics Data System (ADS)

    Yan, Fuhan; Li, Zhaofeng; Jiang, Yichuan

    2016-05-01

    The issues of modeling and analyzing diffusion in social networks have been extensively studied in the last few decades. Recently, many studies focus on uncertain diffusion process. The uncertainty of diffusion process means that the diffusion probability is unpredicted because of some complex factors. For instance, the variety of individuals' opinions is an important factor that can cause uncertainty of diffusion probability. In detail, the difference between opinions can influence the diffusion probability, and then the evolution of opinions will cause the uncertainty of diffusion probability. It is known that controlling the diffusion process is important in the context of viral marketing and political propaganda. However, previous methods are hardly feasible to control the uncertain diffusion process of individual opinion. In this paper, we present suitable strategy to control this diffusion process based on the approximate estimation of the uncertain factors. We formulate a model in which the diffusion probability is influenced by the distance between opinions, and briefly discuss the properties of the diffusion model. Then, we present an optimization problem at the background of voting to show how to control this uncertain diffusion process. In detail, it is assumed that each individual can choose one of the two candidates or abstention based on his/her opinion. Then, we present strategy to set suitable initiators and their opinions so that the advantage of one candidate will be maximized at the end of diffusion. The results show that traditional influence maximization algorithms are not applicable to this problem, and our algorithm can achieve expected performance.

  12. Centralized and distributed control architectures under Foundation Fieldbus network.

    PubMed

    Persechini, Maria Auxiliadora Muanis; Jota, Fábio Gonçalves

    2013-01-01

    This paper aims at discussing possible automation and control system architectures based on fieldbus networks in which the controllers can be implemented either in a centralized or in a distributed form. An experimental setup is used to demonstrate some of the addressed issues. The control and automation architecture is composed of a supervisory system, a programmable logic controller and various other devices connected to a Foundation Fieldbus H1 network. The procedures used in the network configuration, in the process modelling and in the design and implementation of controllers are described. The specificities of each one of the considered logical organizations are also discussed. Finally, experimental results are analysed using an algorithm for the assessment of control loops to compare the performances between the centralized and the distributed implementations. Copyright © 2012 ISA. Published by Elsevier Ltd. All rights reserved.

  13. Decision-making process related to treatment and management in Korean women with breast cancer: Finding the right individualized healthcare trajectory.

    PubMed

    Kim, Kkotbong; Yang, Jinhyang

    2017-06-01

    After being diagnosed with breast cancer, women must make a number of decisions about their treatment and management. When the decision-making process among breast cancer patients is ineffective, it results in harm to their health. Little is known about the decision-making process of breast cancer patients during the entire course of treatment and management. We investigated women with breast cancer to explore the decision-making processes related to treatment and management. Eleven women participated, all of whom were receiving treatment or management in Korea. The average participant age was 43.5years. For data collection and analysis, a grounded theory methodology was used. Through constant comparative analyses, a core category emerged that we referred to as "finding the right individualized healthcare trajectory." The decision-making process occurred in four phases: turmoil, exploration, balance, and control. The turmoil phase included weighing the credibility of information and lowering the anxiety level. The exploration phase included assessing the expertise/promptness of medical treatment and evaluating the effectiveness of follow-up management. The balance phase included performing analyses from multiple angles and rediscovering value as a human being. The control phase included constructing an individualized management system and following prescribed and other management options. It is important to provide patients with accurate information related to the treatment and management of breast cancer so that they can make effective decisions. Healthcare providers should engage with patients on issues related to their disease, understand the burden placed on patients because of issues related to their sex, and ensure that the patient has a sufficient support system. The results of this study can be used to develop phase-specific, patient-centered, and tailored interventions for breast cancer patients. Copyright © 2017 Elsevier Inc. All rights reserved.

  14. Parallel Distributed Processing at 25: further explorations in the microstructure of cognition.

    PubMed

    Rogers, Timothy T; McClelland, James L

    2014-08-01

    This paper introduces a special issue of Cognitive Science initiated on the 25th anniversary of the publication of Parallel Distributed Processing (PDP), a two-volume work that introduced the use of neural network models as vehicles for understanding cognition. The collection surveys the core commitments of the PDP framework, the key issues the framework has addressed, and the debates the framework has spawned, and presents viewpoints on the current status of these issues. The articles focus on both historical roots and contemporary developments in learning, optimality theory, perception, memory, language, conceptual knowledge, cognitive control, and consciousness. Here we consider the approach more generally, reviewing the original motivations, the resulting framework, and the central tenets of the underlying theory. We then evaluate the impact of PDP both on the field at large and within specific subdomains of cognitive science and consider the current role of PDP models within the broader landscape of contemporary theoretical frameworks in cognitive science. Looking to the future, we consider the implications for cognitive science of the recent success of machine learning systems called "deep networks"-systems that build on key ideas presented in the PDP volumes. Copyright © 2014 Cognitive Science Society, Inc.

  15. [In vitro studies of factors possibly influencing the performance of latex condoms].

    PubMed

    Guigon, P; Breton, D; Mendes-Oustric, A C; Pech, A; Clair, P

    2005-11-01

    Male condoms are undoubtedly the best protection against sexually transmitted diseases. The French Military Health Service buys condoms from civilian manufacturers using a public purchasing process. This process includes strict technical analysis that allows selection of the best supplier. In addition each batch of condoms delivered to French armed forces undergoes quality testing in the laboratory of the Armed Services Central Pharmacy before being distributed to troops. Despite these strict control measures, several isss remain unclear. One issue involves the shelf life of condoms stored in warm humid tropical conditions. Another issue involves the effect of lubricants on condom quality. The purpose of this report is to describe a study designed to gain insight into these two issues. This study was conducted by the Armed Services Central Pharmacy in colaboration with the Procuremnt and Central Establishment Directorate. Findings showed that stage conditions have no negative effects on the intrinsic physico-chemial properties of condoms supplied by two different manufacturers. Conversely use of inadequate lubricants (alimentary or cosmetic compounds) appeared to have extremely deleterious effects on condom quality. Laboratory tests showed that lubricants composed mainly of fatty acids dramatically decreased the effectiveness of condoms.

  16. State of the art of fine patterned Si TFT

    NASA Astrophysics Data System (ADS)

    Noguchi, Takashi

    2003-05-01

    Performance and relating subject for fine patterned Si TFT (Thin Film Transistor) are reviewed and discussed from a viewpoint of device and/or fabrication process based on reported results. Poly-Si TFTs fabricated on glass using low-temperature process are studied extensively for the application to LCD (Liquid Crystal Display) or OLED (Organic Light Emitting Diode) Display. Currently, the research target for the TFT application is emphasized on the highly functional system on glass or the display on flexible substrate by adopting an effective crystallizing technique of SPC (Solid Phase Crystallization) or ELC (Excimer Laser Crystallization). Improvement of device characteristics such as an enhancement of carrier mobility has been studied intensively by enlarging the grain size. Reduction of the voltage and shrinkage of the device size are the trend of Si LSI, which arise a peculiar issue of uniformity or an anisotropy problem for the device characteristics in the large grained poly-Si film. Some trial approaches for solving the issues such as nucleation control for the grain growth or lateral grain growth are proposed, so far. By overcoming the issues, coming SOP (System on Panel) era using the Si TFTs is expected.

  17. The cognitive nature of action - functional links between cognitive psychology, movement science, and robotics.

    PubMed

    Schack, Thomas; Ritter, Helge

    2009-01-01

    This paper examines the cognitive architecture of human action, showing how it is organized over several levels and how it is built up. Basic action concepts (BACs) are identified as major building blocks on a representation level. These BACs are cognitive tools for mastering the functional demands of movement tasks. Results from different lines of research showed that not only the structure formation of mental representations in long-term memory but also chunk formation in working memory are built up on BACs and relate systematically to movement structures. It is concluded that such movement representations might provide the basis for action implementation and action control in skilled voluntary movements in the form of cognitive reference structures. To simulate action implementation we discuss challenges and issues that arise when we try to replicate complex movement abilities in robots. Among the key issues to be addressed is the question how structured representations can arise during skill acquisition and how the underlying processes can be understood sufficiently succinctly to replicate them on robot platforms. Working towards this goal, we translate our findings in studies of motor control in humans into models that can guide the implementation of cognitive robot architectures. Focusing on the issue of manual action control, we illustrate some results in the context of grasping with a five-fingered anthropomorphic robot hand.

  18. Thermographic Assessment of the HAZ Properties and Structure of Thermomechanically Treated Steel

    NASA Astrophysics Data System (ADS)

    Górka, Jacek; Janicki, Damian; Fidali, Marek; Jamrozik, Wojciech

    2017-12-01

    Thermomechanically processed steels are materials of great mechanical properties connected with more than good weldability. This mixture makes them interesting for different types of industrial applications. When creating welded joints, a specified amount of heat is introduced into the welding area and a so called heat-affected zone (HAZ) is formed. The key issue is to reduce the width of the HAZ, because properties of the material in the HAZ are worse than in the base material. In the paper, thermographic measurements of HAZ temperatures were presented as a potential tool for quality assuring the welding process in terms of monitoring and control. The main issue solved was the precise temperature measurement in terms of varying emissivity during a welding thermal cycle. A model of emissivity changes was elaborated and successfully applied. Additionally, material in the HAZ was tested to reveal its properties and connect changes of those properties with heating parameters. The obtained results prove that correctly modeled emissivity allows measurement of temperature, which is a valuable tool for welding process monitoring.

  19. Under-sampling in a Multiple-Channel Laser Vibrometry System

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Corey, Jordan

    2007-03-01

    Laser vibrometry is a technique used to detect vibrations on objects using the interference of coherent light with itself. Most vibrometry systems process only one target location at a time, but processing multiple locations simultaneously provides improved detection capabilities. Traditional laser vibrometry systems employ oversampling to sample the incoming modulated-light signal, however as the number of channels increases in these systems, certain issues arise such a higher computational cost, excessive heat, increased power requirements, and increased component cost. This thesis describes a novel approach to laser vibrometry that utilizes undersampling to control the undesirable issues associated with over-sampled systems. Undersamplingmore » allows for significantly less samples to represent the modulated-light signals, which offers several advantages in the overall system design. These advantages include an improvement in thermal efficiency, lower processing requirements, and a higher immunity to the relative intensity noise inherent in laser vibrometry applications. A unique feature of this implementation is the use of a parallel architecture to increase the overall system throughput. This parallelism is realized using a hierarchical multi-channel architecture based on off-the-shelf programmable logic devices (PLDs).« less

  20. Overview of Carbon Dioxide Control Issues During International Space Station/Space Shuttle Joint Docked Operations

    NASA Technical Reports Server (NTRS)

    Matty, Christopher M.

    2010-01-01

    Crewed space vehicles have a common requirement to remove the carbon dioxide (CO2) created by the metabolic processes of the crew. The space shuttle [Space Transportation System (STS)] and International Space Station (ISS) each have systems in place that allow control and removal of CO2 from the habitable cabin environment. During periods in which the space shuttle is docked to the ISS, known as "joint docked operations," the space shuttle and ISS share a common atmosphere environment. During this period, an elevated amount of CO2 is produced through the combined metabolic activity of the STS and ISS crews. This elevated CO2 production, together with the large effective atmosphere created by collective volumes of the docked vehicles, creates a unique set of requirements for CO2 removal. This paper will describe individual CO2 control plans implemented by STS and ISS engineering teams, as well as the integrated plans used when both vehicles are docked. The paper will also discuss some of the issues and anomalies experienced by both engineering teams.

  1. Overview of Carbon Dioxide Control Issues During International Space Station/Space Shuttle Joint Docked Operations

    NASA Technical Reports Server (NTRS)

    Matty, Christopher M.; Hayley, Elizabeth P.

    2009-01-01

    Manned space vehicles have a common requirement to remove the Carbon Dioxide (CO2) created by the metabolic processes of the crew. The Space Shuttle and International Space Station (ISS) each have systems in place to allow control and removal of CO2 from the habitable cabin environment. During periods where the Space Shuttle is docked to ISS, known as joint docked operations, the Space Shuttle and ISS share a common atmosphere environment. During this period there is an elevated production of CO2 caused by the combined metabolic activity of the Space Shuttle and ISS crew. This elevated CO2 production, combined with the large effective atmosphere created by the collective volumes of the docked vehicles, creates a unique set of requirements for CO2 removal. This paper will describe the individual CO2 control plans implemented by the Space Shuttle and ISS engineering teams, as well as the integrated plans used when both vehicles are docked. In addition, the paper will discuss some of the issues and anomalies experienced by both engineering teams.

  2. Processing mechanics of alternate twist ply (ATP) yarn technology

    NASA Astrophysics Data System (ADS)

    Elkhamy, Donia Said

    Ply yarns are important in many textile manufacturing processes and various applications. The primary process used for producing ply yarns is cabling. The speed of cabling is limited to about 35m/min. With the world's increasing demands of ply yarn supply, cabling is incompatible with today's demand activated manufacturing strategies. The Alternate Twist Ply (ATP) yarn technology is a relatively new process for producing ply yarns with improved productivity and flexibility. This technology involves self plying of twisted singles yarn to produce ply yarn. The ATP process can run more than ten times faster than cabling. To implement the ATP process to produce ply yarns there are major quality issues; uniform Twist Profile and yarn Twist Efficiency. The goal of this thesis is to improve these issues through process modeling based on understanding the physics and processing mechanics of the ATP yarn system. In our study we determine the main parameters that control the yarn twist profile. Process modeling of the yarn twist across different process zones was done. A computational model was designed to predict the process parameters required to achieve a square wave twist profile. Twist efficiency, a measure of yarn torsional stability and bulk, is determined by the ratio of ply yarn twist to singles yarn twist. Response Surface Methodology was used to develop the processing window that can reproduce ATP yarns with high twist efficiency. Equilibrium conditions of tensions and torques acting on the yarns at the self ply point were analyzed and determined the pathway for achieving higher twist efficiency. Mechanistic modeling relating equilibrium conditions to the twist efficiency was developed. A static tester was designed to zoom into the self ply zone of the ATP yarn. A computer controlled, prototypic ATP machine was constructed and confirmed the mechanistic model results. Optimum parameters achieving maximum twist efficiency were determined in this study. The successful results of this work have led to the filing of a US patent disclosing the method for producing ATP yarns with high yarn twist efficiency using a high convergence angle at the self ply point together with applying ply torque.

  3. Process identification of the SCR system of coal-fired power plant for de-NOx based on historical operation data.

    PubMed

    Li, Jian; Shi, Raoqiao; Xu, Chuanlong; Wang, Shimin

    2018-05-08

    The selective catalytic reduction (SCR) system, as one principal flue gas treatment method employed for the NO x emission control of the coal-fired power plant, is nonlinear and time-varying with great inertia and large time delay. It is difficult for the present SCR control system to achieve satisfactory performance with the traditional feedback and feedforward control strategies. Although some improved control strategies, such as the Smith predictor control and the model predictive control, have been proposed for this issue, a well-matched identification model is essentially required to realize a superior control of the SCR system. Industrial field experiment is an alternative way to identify the SCR system model in the coal-fired power plant. But it undesirably disturbs the operation system and is costly in time and manpower. In this paper, a process identification model of the SCR system is proposed and developed by applying the asymptotic method to the sufficiently excited data, selected from the original historical operation database of a 350 MW coal-fired power plant according to the condition number of the Fisher information matrix. Numerical simulations are carried out based on the practical historical operation data to evaluate the performance of the proposed model. Results show that the proposed model can efficiently achieve the process identification of the SCR system.

  4. PREFACE: 12th European Workshop on Advanced Control and Diagnosis (ACD 2015)

    NASA Astrophysics Data System (ADS)

    Straka, Ondřej; Punčochář, Ivo; Duník, Jindřich

    2015-11-01

    The 12th European Workshop on Advanced Control and Diagnosis (ACD 2015) took place at the Research Centre NTIS - New Technologies for the Information Society, Faculty of Applied Sciences, University of West Bohemia, Pilsen, Czech Republic, on November 19 - 20, 2015. The annual European Workshop on Advanced Control and Diagnosis has been organized since 2003 by Control Engineering departments of several European universities in Germany, France, the UK, Poland, Italy, Hungary, and Denmark to bring together senior and junior academics and engineers from diverse fields of automatic control, fault detection, and signal processing. The workshop provides an opportunity for researchers and developers to present their recent theoretical developments, practical applications, or even open problems. It also offers a great opportunity for industrial partners to express their needs and priorities and to review the current activities in the fields. A total of 74 papers have been submitted for ACD 2015. Based on the peer reviews 48 papers were accepted for the oral presentation and 10 papers for the poster presentation. The accepted papers covered areas of control theory and applications, identification, estimation, signal processing, and fault detection. In addition, four excellent plenary lectures were delivered by Prof. Fredrik Gustafsson (Automotive Sensor Mining for Tire Pressure Monitoring), Prof. Vladimír Havlena (Advanced Process Control for Energy Efficiency), Prof. Silvio Simani (Advanced Issues on Wind Turbine Modelling and Control), and Prof. Robert Babuška (Learning Control in Robotics). The ACD 2015 was for the first time in the workshop history co-sponsored by the International Federation of Automatic Control (IFAC). On behalf of the ACD 2015 organising committee, we would like to thank all those who prepared and submitted papers, participated in the peer review process, supported, and attended the workshop.

  5. EDITORIAL: Nonlinear optical manipulation, patterning and control in nano- and micro-scale systems Nonlinear optical manipulation, patterning and control in nano- and micro-scale systems

    NASA Astrophysics Data System (ADS)

    Denz, Cornelia; Simoni, Francesco

    2009-03-01

    Nonlinearities are becoming more and more important for a variety of applications in nanosciences, bio-medical sciences, information processing and photonics. For applications at the crossings of these fields, especially microscopic and nanoscopic imaging and manipulation, nonlinearities play a key role. They may range from simple nonlinear parameter changes up to applications in manipulating, controlling and structuring material by light, or the manipulation of light by light itself. It is this area between basic nonlinear optics and photonic applications that includes `hot' topics such as ultra-resolution optical microscopy, micro- and nanomanipulation and -structuring, or nanophotonics. This special issue contains contributions in this field, many of them from the International Conference on Nonlinear Microscopy and Optical Control held in conjunction with a network meeting of the ESF COST action MP0604 `Optical Micromanipulation by Nonlinear Nanophotonics', 19-22 February 2008, Münster, Germany. Throughout this special issue, basic investigations of material structuring by nonlinear light--matter interaction, light-induced control of nanoparticles, and novel nonlinear material investigation techniques, are presented, covering the basic field of optical manipulation and control. These papers are followed by impressive developments of optical tweezers. Nowadays, optical phase contrast tweezers, twin and especially multiple beam traps, develop particle control in a new dimension: particles can be arranged, sorted and identified with high throughput. One of the most prominent forthcoming applications of optical tweezers is in the field of microfluidics. The action of light on fluids will open new horizons in microfluidic manipulation and control. The field of optical manipulation and control is a very broad field that has developed in an impressive way, in a short time, in Europe with the installation of the MP0604 network. Top researchers from 19 countries are collaborating in this network. The editors are grateful for the active participation of all colleagues in this network, in the network meeting, and in making this special issue a success. We also extend our thanks to a great Journal of Optics A staff that have supported the editing of this special issue, especially the Publishing Editor, Julia Dickinson. Among the active colleagues in our network was also Associate Professor Erik Fällman, Umea University, Sweden. It was with great sadness that we learnt of the death of our colleague and friend in June 2008. We dedicate this special issue to his memory, and the active and always engaged contribution he made both to our conference and to the field of optical micromanipulation and optical control. Erik will be particularly remembered for his applications of optical force measurements on bacterial pili adhesion, which has stimulated a worldwide experimental and theoretical interest in this field.

  6. Sexual maturation and control issues among sexually abused and non-abused anorexia patients.

    PubMed

    Walsh, J; Burns, F

    2000-09-01

    To assess the relative salience of the maintenance of control and the avoidance of sexual maturation as sources of motivation for maintaining pathological eating behaviours among sexually abused anorexic patients. A two-factor mixed experimental design was employed. Three independent groups (sexually abused anorexics (N = 12); non-abused anorexics (N = 9); non-anorexic/non-abused controls (N = 12)) constituted the between-subjects factor. Allocation to abuse/non-abuse group was dependent upon replies to a questionnaire-based measure of unwanted sexual experience. The within-subjects factor comprised three conditions in which words of various colours were presented to participants for colour-naming (Stroop, 1935). The conditions were represented by lists of neutral words, sexual maturation words, and control-related words. Two trials were carried out in each condition and mean response times were measured. Within-group analyses revealed that interference was greater from sexual maturation words than from control-related words among the sexually-abused anorexics, but of equal magnitude among non-abused counterparts. Between-groups analyses found that abused patients experienced marginally greater cognitive interference from sexual maturation words than the non-abused patients. Theoretically, support is offered for elaborated schematic models of cognitive processing. Clinically, treatment interventions may need to pay particular attention to issues of sexual maturation among sexually abused anorexic patients.

  7. Supplemental Information for New York State Standardized Interconnection Requirements

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ingram, Michael; Narang, David J.; Mather, Barry A.

    This document is intended to aid in the understanding and application of the New York State Standardized Interconnection Requirements (SIR) and Application Process for New Distributed Generators 5 MW or Less Connected in Parallel with Utility Distribution Systems, and it aims to provide supplemental information and discussion on selected topics relevant to the SIR. This guide focuses on technical issues that have to date resulted in the majority of utility findings within the context of interconnecting photovoltaic (PV) inverters. This guide provides background on the overall issue and related mitigation measures for selected topics, including substation backfeeding, anti-islanding and considerationsmore » for monitoring and controlling distributed energy resources (DER).« less

  8. Using Community-Based Participatory Research to Identify Environmental Justice Issues in an Inner-City Community and Inform Urban Planning.

    PubMed

    Mansyur, Carol Leler; Jeng, Hueiwang Anna; Holloman, Erica; DeBrew, Linwood

    2016-01-01

    The Southeast CARE Coalition has been using community-based participatory research to examine environmental degradation in the Southeast Community, Newport News, Virginia. A survey was developed to collect assessment data. Up to 66% of respondents were concerned about environmental problems in their community. Those with health conditions were significantly more likely to identify specific environmental problems. The top 5 environmental concerns included coal dust, air quality, crime, water quality, and trash. The community-based participatory research process is building community capacity and participation, providing community input into strategic planning, and empowering community members to take control of environmental justice issues in their community.

  9. Localized structures in dissipative media: from optics to plant ecology.

    PubMed

    Tlidi, M; Staliunas, K; Panajotov, K; Vladimirov, A G; Clerc, M G

    2014-10-28

    Localized structures (LSs) in dissipative media appear in various fields of natural science such as biology, chemistry, plant ecology, optics and laser physics. The proposal for this Theme Issue was to gather specialists from various fields of nonlinear science towards a cross-fertilization among active areas of research. This is a cross-disciplinary area of research dominated by nonlinear optics due to potential applications for all-optical control of light, optical storage and information processing. This Theme Issue contains contributions from 18 active groups involved in the LS field and have all made significant contributions in recent years. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

  10. Critical Role of Transforming Growth Factor Beta in Different Phases of Wound Healing

    PubMed Central

    Pakyari, Mohammadreza; Farrokhi, Ali; Maharlooei, Mohsen Khosravi; Ghahary, Aziz

    2013-01-01

    Significance This review highlights the critical role of transforming growth factor beta (TGF-β)1–3 within different phases of wound healing, in particular, late-stage wound healing. It is also very important to identify the TGF-β1–controlling factors involved in slowing down the healing process upon wound epithelialization. Recent Advances TGF-β1, as a growth factor, is a known proponent of dermal fibrosis. Several strategies to modulate or regulate TGF's actions have been thoroughly investigated in an effort to create successful therapies. This study reviews current discourse regarding the many roles of TGF-β1 in wound healing by modulating infiltrated immune cells and the extracellular matrix. Critical Issues It is well established that TGF-β1 functions as a wound-healing promoting factor, and thereby if in excess it may lead to overhealing outcomes, such as hypertrophic scarring and keloid. Thus, the regulation of TGF-β1 in the later stages of the healing process remains as critical issue of which to better understand. Future Directions One hypothesis is that cell communication is the key to regulate later stages of wound healing. To elucidate the role of keratinocyte/fibroblast cross talk in controlling the later stages of wound healing we need to: (1) identify those keratinocyte-released factors which would function as wound-healing stop signals, (2) evaluate the functionality of these factors in controlling the outcome of the healing process, and (3) formulate topical vehicles for these antifibrogenic factors to improve or even prevent the development of hypertrophic scarring and keloids as a result of deep trauma, burn injuries, and any type of surgical incision. PMID:24527344

  11. Role of Process Control in Improving Space Vehicle Safety A Space Shuttle External Tank Example

    NASA Technical Reports Server (NTRS)

    Safie, Fayssal M.; Nguyen, Son C.; Burleson, Keith W.

    2006-01-01

    Developing a safe and reliable space vehicle requires good design and good manufacturing, or in other words "design it right and build it right". A great design can be hard to build or manufacture mainly due to difficulties related to quality. Specifically, process control can be a challenge. As a result, the system suffers from low quality which leads to low reliability and high system risk. The Space Shuttle has experienced some of those cases, but has overcome these difficulties through extensive redesign efforts and process enhancements. One example is the design of the hot gas temperature sensor on the Space Shuttle Main Engine (SSME), which resulted in failure of the sensor in flight and led to a redesign of the sensor. The most recent example is the Space Shuttle External Tank (ET) Thermal Protection System (TPS) reliability issues that contributed to the Columbia accident. As a result, extensive redesign and process enhancement activities have been performed over the last two years to minimize the sensitivities and difficulties of the manual TPS application process.

  12. Understanding and Shaping the Morphology of the Barrier Layer of Supported Porous Anodized Alumina on Gold Underlayers.

    PubMed

    Berger, Nele; Es-Souni, Mohammed

    2016-07-12

    Large-area ordered nanorod (NR) arrays of various functional materials can be easily and cost-effectively processed using on-substrate anodized porous aluminum oxide (PAO) films as templates. However, reproducibility in the processing of PAO films is still an issue because they are prone to delamination, and control of fabrication parameters such as electrolyte type and concentration and anodizing time is critical for making robust templates and subsequently mechanically reliable NR arrays. In the present work, we systematically investigate the effects of the fabrication parameters on pore base morphology, devise a method to avoid delamination, and control void formation under the barrier layer of PAO films on gold underlayers. Via systematic control of the anodization parameters, particularly the anodization current density and time, we follow the different stages of void development and discuss their formation mechanisms. The practical aspect of this work demonstrates how void size can be controlled and how void formation can be utilized to control the shape of NR bases for improving the mechanical stability of the NRs.

  13. Experimental confirmation of a PDE-based approach to design of feedback controls

    NASA Technical Reports Server (NTRS)

    Banks, H. T.; Smith, Ralph C.; Brown, D. E.; Silcox, R. J.; Metcalf, Vern L.

    1995-01-01

    Issues regarding the experimental implementation of partial differential equation based controllers are discussed in this work. While the motivating application involves the reduction of vibration levels for a circular plate through excitation of surface-mounted piezoceramic patches, the general techniques described here will extend to a variety of applications. The initial step is the development of a PDE model which accurately captures the physics of the underlying process. This model is then discretized to yield a vector-valued initial value problem. Optimal control theory is used to determine continuous-time voltages to the patches, and the approximations needed to facilitate discrete time implementation are addressed. Finally, experimental results demonstrating the control of both transient and steady state vibrations through these techniques are presented.

  14. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Martino, Mikaël M.; Briquez, Priscilla S.; Maruyama, Kenta

    Growth factors are very promising molecules to enhance bone regeneration. However, their translation to clinical use has been seriously limited, facing issues related to safety and cost-effectiveness. These problems derive from the vastly supra-physiological doses of growth factor used without optimized delivery systems. Therefore, these issues have motivated the development of new delivery systems allowing better control of the spatio-temporal release and signaling of growth factors. Because the extracellular matrix (ECM) naturally plays a fundamental role in coordinating growth factor activity in vivo, a number of novel delivery systems have been inspired by the growth factor regulatory function of themore » ECM. After introducing the role of growth factors during the bone regeneration process, this review exposes different issues that growth factor-based therapies have encountered in the clinic and highlights recent delivery approaches based on the natural interaction between growth factor and the ECM.« less

  15. Evaluation of Secure Computation in a Distributed Healthcare Setting.

    PubMed

    Kimura, Eizen; Hamada, Koki; Kikuchi, Ryo; Chida, Koji; Okamoto, Kazuya; Manabe, Shirou; Kuroda, Tomohiko; Matsumura, Yasushi; Takeda, Toshihiro; Mihara, Naoki

    2016-01-01

    Issues related to ensuring patient privacy and data ownership in clinical repositories prevent the growth of translational research. Previous studies have used an aggregator agent to obscure clinical repositories from the data user, and to ensure the privacy of output using statistical disclosure control. However, there remain several issues that must be considered. One such issue is that a data breach may occur when multiple nodes conspire. Another is that the agent may eavesdrop on or leak a user's queries and their results. We have implemented a secure computing method so that the data used by each party can be kept confidential even if all of the other parties conspire to crack the data. We deployed our implementation at three geographically distributed nodes connected to a high-speed layer two network. The performance of our method, with respect to processing times, suggests suitability for practical use.

  16. The Integration of COTS/GOTS within NASA's HST Command and Control System

    NASA Technical Reports Server (NTRS)

    Pfarr, Thomas; Reis, James E.

    2001-01-01

    NASA's mission critical Hubble Space Telescope (HST) command and control system has been re-engineered with commercial-off-the-shelf (COTS/GOTS) and minimal custom code. This paper focuses on the design of this new HST Control Center System (CCS) and the lessons learned throughout its development. CCS currently utilizes more than 30 COTS/GOTS products with an additional 1/2 million lines of custom glueware code; the new CCS exceeds the capabilities of the original system while significantly reducing the lines of custom code by more than 50%. The lifecycle of COTS/GOTS products will be examined including the package selection process, evaluation process, and integration process. The advantages, disadvantages, issues, concerns, and lessons learned for integrating COTS/GOTS into the NASA's mission critical HST CCS will be examined in detail. This paper will reveal the many hidden costs of COTS/GOTS solutions when compared to traditional custom code development efforts; this paper will show the high cost of COTS/GOTS solutions including training expenses, consulting fees, and long-term maintenance expenses.

  17. The role of the ventro-lateral prefrontal cortex in idiom comprehension: An rTMS study.

    PubMed

    Häuser, Katja I; Titone, Debra A; Baum, Shari R

    2016-10-01

    Previous research is equivocal with respect to the neural substrates of idiom processing. Particularly elusive is the role of the left ventro-lateral prefrontal cortex (VLPFC), a region implicated in semantic control generally. Although fMRI studies have shown that the left VLPFC is active during idiom processing (see Rapp et al. (2012), for review), rTMS studies have failed to corroborate a clear role of this prefrontal region (e.g., Oliveri et al., 2004). We investigated this issue using a semantic meaningfulness judgment task that compared idiom comprehension following rTMS-stimulation to the left VLPFC relative to a control site (vertex). We also investigated whether individual differences in general cognitive capacity among comprehenders modulated the effects of rTMS. The results indicate that left VLPFC stimulation particularly affected the processing of low-familiar idioms, possibly because these items involve a maximal semantic conflict between a salient literal and less-known figurative meaning. Of note, this pattern only emerged for comprehenders with higher cognitive control capacity, possibly because they were more likely to activate or maintain multiple semantic representations during idiom processing, which required VLPFC integrity. Taken together, the results support the importance of the left VLPFC to idiom processing. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. Evaluation of the External RNA Controls Consortium (ERCC) reference material using a modified Latin square design.

    PubMed

    Pine, P Scott; Munro, Sarah A; Parsons, Jerod R; McDaniel, Jennifer; Lucas, Anne Bergstrom; Lozach, Jean; Myers, Timothy G; Su, Qin; Jacobs-Helber, Sarah M; Salit, Marc

    2016-06-24

    Highly multiplexed assays for quantitation of RNA transcripts are being used in many areas of biology and medicine. Using data generated by these transcriptomic assays requires measurement assurance with appropriate controls. Methods to prototype and evaluate multiple RNA controls were developed as part of the External RNA Controls Consortium (ERCC) assessment process. These approaches included a modified Latin square design to provide a broad dynamic range of relative abundance with known differences between four complex pools of ERCC RNA transcripts spiked into a human liver total RNA background. ERCC pools were analyzed on four different microarray platforms: Agilent 1- and 2-color, Illumina bead, and NIAID lab-made spotted microarrays; and two different second-generation sequencing platforms: the Life Technologies 5500xl and the Illumina HiSeq 2500. Individual ERCC controls were assessed for reproducible performance in signal response to concentration among the platforms. Most demonstrated linear behavior if they were not located near one of the extremes of the dynamic range. Performance issues with any individual ERCC transcript could be attributed to detection limitations, platform-specific target probe issues, or potential mixing errors. Collectively, these pools of spike-in RNA controls were evaluated for suitability as surrogates for endogenous transcripts to interrogate the performance of the RNA measurement process of each platform. The controls were useful for establishing the dynamic range of the assay, as well as delineating the useable region of that range where differential expression measurements, expressed as ratios, would be expected to be accurate. The modified Latin square design presented here uses a composite testing scheme for the evaluation of multiple performance characteristics: linear performance of individual controls, signal response within dynamic range pools of controls, and ratio detection between pairs of dynamic range pools. This compact design provides an economical sample format for the evaluation of multiple external RNA controls within a single experiment per platform. These results indicate that well-designed pools of RNA controls, spiked into samples, provide measurement assurance for endogenous gene expression studies.

  19. Optimum processing of mammographic film.

    PubMed

    Sprawls, P; Kitts, E L

    1996-03-01

    Underprocessing of mammographic film can result in reduced contrast and visibility of breast structures and an unnecessary increase in radiation dose to the patient. Underprocessing can be caused by physical factors (low developer temperature, inadequate development time, insufficient developer agitation) or chemical factors (developer not optimized for film type; overdiluted, underreplenished, contaminated, or frequently changed developer). Conventional quality control programs are designed to produce consistent processing but do not address the issue of optimum processing. Optimum processing is defined as the level of processing that produces the film performance characteristics (contrast and sensitivity) specified by the film manufacturer. Optimum processing of mammographic film can be achieved by following a two-step protocol. The first step is to set up the processing conditions according to recommendations from the film and developer chemistry manufacturers. The second step is to verify the processing results by comparing them with sensitometric data provided by the film manufacturer.

  20. Simulation to coating weight control for galvanizing

    NASA Astrophysics Data System (ADS)

    Wang, Junsheng; Yan, Zhang; Wu, Kunkui; Song, Lei

    2013-05-01

    Zinc coating weight control is one of the most critical issues for continuous galvanizing line. The process has the characteristic of variable-time large time delay, nonlinear, multivariable. It can result in seriously coating weight error and non-uniform coating. We develop a control system, which can automatically control the air knives pressure and its position to give a constant and uniform zinc coating, in accordance with customer-order specification through an auto-adaptive empirical model-based feed forward adaptive controller, and two model-free adaptive feedback controllers . The proposed models with controller were applied to continuous galvanizing line (CGL) at Angang Steel Works. By the production results, the precise and stability of the control model reduces over-coating weight and improves coating uniform. The product for this hot dip galvanizing line does not only satisfy the customers' quality requirement but also save the zinc consumption.

  1. Engineering application of anaerobic ammonium oxidation process in wastewater treatment.

    PubMed

    Mao, Nianjia; Ren, Hongqiang; Geng, Jinju; Ding, Lili; Xu, Ke

    2017-08-01

    Anaerobic ammonium oxidation (Anammox), a promising biological nitrogen removal process, has been verified as an efficient, sustainable and cost-effective alternative to conventional nitrification and denitrification processes. To date, more than 110 full-scale anammox plants have been installed and are in operation, treating industrial NH 4 + -rich wastewater worldwide, and anammox-based technologies are flourishing. This review the current state of the art for engineering applications of the anammox process, including various anammox-based technologies, reactor selection and attempts to apply it at different wastewater plants. Process control and implementation for stable performance are discussed as well as some remaining issues concerning engineering application are exposed, including the start-up period, process disturbances, greenhouse gas emissions and especially mainstream anammox applications. Finally, further development of the anammox engineering application is proposed in this review.

  2. Dealing with emotions when the ability to cry is hampered: emotion processing and regulation in patients with primary Sjögren's syndrome.

    PubMed

    van Leeuwen, Ninke; Bossema, Ercolie R; van Middendorp, Henriët; Kruize, Aike A; Bootsma, Hendrika; Bijlsma, Johannes W J; Geenen, Rinie

    2012-01-01

    The hampered ability to cry in patients with Sjögren's syndrome may affect their ways of dealing with emotions. The aim of this study was to examine differences in emotion processing and regulation between people with and without Sjögren's syndrome and correlations of emotion processing and regulation with mental well-being. In 300 patients with primary Sjögren's syndrome and 100 demographically matched control participants (mean age 56.8 years, 93% female), emotion processing (affect intensity and alexithymia, i.e. difficulty identifying and describing feelings), emotion regulation (cognitive reappraisal, suppression and expression of emotions), and mental well-being were assessed. Criteria for clinical alexithymia applied to 22% of the patients and 12% of the control participants; patients had significantly more difficulty identifying feelings than control participants. No other significant differences in emotion processing and emotion regulation were found. In patients, the emotion processing styles affect intensity and alexithymia (0.32

  3. An introduction to statistical process control in research proteomics.

    PubMed

    Bramwell, David

    2013-12-16

    Statistical process control is a well-established and respected method which provides a general purpose, and consistent framework for monitoring and improving the quality of a process. It is routinely used in many industries where the quality of final products is critical and is often required in clinical diagnostic laboratories [1,2]. To date, the methodology has been little utilised in research proteomics. It has been shown to be capable of delivering quantitative QC procedures for qualitative clinical assays [3] making it an ideal methodology to apply to this area of biological research. To introduce statistical process control as an objective strategy for quality control and show how it could be used to benefit proteomics researchers and enhance the quality of the results they generate. We demonstrate that rules which provide basic quality control are easy to derive and implement and could have a major impact on data quality for many studies. Statistical process control is a powerful tool for investigating and improving proteomics research work-flows. The process of characterising measurement systems and defining control rules forces the exploration of key questions that can lead to significant improvements in performance. This work asserts that QC is essential to proteomics discovery experiments. Every experimenter must know the current capabilities of their measurement system and have an objective means for tracking and ensuring that performance. Proteomic analysis work-flows are complicated and multi-variate. QC is critical for clinical chemistry measurements and huge strides have been made in ensuring the quality and validity of results in clinical biochemistry labs. This work introduces some of these QC concepts and works to bridge their use from single analyte QC to applications in multi-analyte systems. This article is part of a Special Issue entitled: Standardization and Quality Control in Proteomics. Copyright © 2013 The Author. Published by Elsevier B.V. All rights reserved.

  4. 10 CFR 708.34 - What is the process for issuing an appeal decision?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... appeal decision to all parties and to the Head of Field Element or EC Director having jurisdiction over... 10 Energy 4 2010-01-01 2010-01-01 false What is the process for issuing an appeal decision? 708.34..., Hearing and Decision Process § 708.34 What is the process for issuing an appeal decision? (a) If there is...

  5. Continuing Education of the Professions: Issues, Ethics, and Conflicts

    ERIC Educational Resources Information Center

    Frandson, Phillip E.

    1975-01-01

    Relicensure has emerged as one of today's key issues in the continuing education of the professional. The conflict is clear: Who shall be controlling force? A grid involving the six issues focuses on the constituencies who seek to control these issues. The medical profession is used as an example. (BP)

  6. Proceedings of the Workshop on software tools for distributed intelligent control systems

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Herget, C.J.

    1990-09-01

    The Workshop on Software Tools for Distributed Intelligent Control Systems was organized by Lawrence Livermore National Laboratory for the United States Army Headquarters Training and Doctrine Command and the Defense Advanced Research Projects Agency. The goals of the workshop were to the identify the current state of the art in tools which support control systems engineering design and implementation, identify research issues associated with writing software tools which would provide a design environment to assist engineers in multidisciplinary control design and implementation, formulate a potential investment strategy to resolve the research issues and develop public domain code which can formmore » the core of more powerful engineering design tools, and recommend test cases to focus the software development process and test associated performance metrics. Recognizing that the development of software tools for distributed intelligent control systems will require a multidisciplinary effort, experts in systems engineering, control systems engineering, and compute science were invited to participate in the workshop. In particular, experts who could address the following topics were selected: operating systems, engineering data representation and manipulation, emerging standards for manufacturing data, mathematical foundations, coupling of symbolic and numerical computation, user interface, system identification, system representation at different levels of abstraction, system specification, system design, verification and validation, automatic code generation, and integration of modular, reusable code.« less

  7. Effect of fossil fuels on the parameters of CO2 capture.

    PubMed

    Nagy, Tibor; Mizsey, Peter

    2013-08-06

    The carbon dioxide capture is a more and more important issue in the design and operation of boilers and/or power stations because of increasing environmental considerations. Such processes, absorber desorber should be able to cope with flue gases from the use of different fossil primary energy sources, in order to guarantee a flexible, stable, and secure energy supply operation. The changing flue gases have significant influence on the optimal operation of the capture process, that is, where the required heating of the desorber is the minimal. Therefore special considerations are devoted to the proper design and control of such boiler and/or power stations equipped with CO2 capture process.

  8. Prediction, Measurement, and Control of Spacecraft Charging Hazards on the International Space Station(ISS)

    NASA Astrophysics Data System (ADS)

    Koontz, Steve; Alred, John; Ellison, Amy; Patton, Thomas; Minow, Joseph; Spetch, William

    2010-09-01

    Orbital inclination, 51.6 degrees, and altitude range, 300 to 400 km,(low-Earth orbit or LEO) determine the ISS spacecraft charging environment. Specific interactions of the ISS electrical power system and metallic structure with the Earth’s ionospheric plasma and the geomagnetic field dominate spacecraft charging processes for ISS. ISS also flies through auroral electron streams at high latitudes. In this paper, we report the character of ISS spacecraft charging processes in Earth’s ionosphere, the results of measurement and modelling of the subject charging processes, and the safety issues for ISS itself as well as for ISS interoperability with respect to extra vehicular activity(EVA) and visiting vehicle proximity operations.

  9. Feedback from video for virtual reality Navigation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tsap, L V

    2000-10-27

    Important preconditions for wide acceptance of virtual reality (VR) systems include their comfort, ease and naturalness to use. Most existing trackers super from discomfort-related issues. For example, body-based trackers (hand controllers, joysticks, helmet attachments, etc.) restrict spontaneity and naturalness of motion, while ground-based devices (e.g., hand controllers) limit the workspace by literally binding an operator to the ground. There are similar problems with controls. This paper describes using real-time video with registered depth information (from a commercially available camera) for virtual reality navigation. Camera-based setup can replace cumbersome trackers. The method includes selective depth processing for increased speed, and amore » robust skin-color segmentation for accounting illumination variations.« less

  10. Arms Sales: Congressional Review Process

    DTIC Science & Technology

    2015-12-17

    the Arms Export Control Act (AECA), Congress must be formally notified 30 calendar days before the Administration can take the final steps to...Commercially licensed arms sales also must be formally notified to Congress 30 calendar days before the export license is issued if they involve the sale...also be formally notified to Congress for review 30 days prior to the license for export being approved. In the case of proposed licences for such

  11. Food Safety and Quality: Who does What in the Federal Government, Volume 2

    DTIC Science & Technology

    1990-12-21

    products; (2) consumers, industry, and health professionals, to aid in promoting a better awareness and understanding of food issues; and (3) foreign...service, food stores, and food vending in the form of model codes; promoting their adoption: and evaluating state programs; " providing sanitation...34 promoting sanitation control over all phases of shellfish growing, har- vesting, processing, and marketing operations; and " disseminating information about

  12. Participants in or Reflectors of the Social Change Process? Six Selected Magazines Consider the Birth Control Controversy, 1915-1925.

    ERIC Educational Resources Information Center

    Fleener, Nickieann

    Twenty-two issues of each of six magazines published between 1915 and 1925 were analyzed to determine whether those magazines served only as mirrors of social change or took a more active role, either as agents of social change or as agents of social conservatism. Specifically, the study examined the manner in which the following magazines covered…

  13. Preceedings of the International Congress (12th), Corrosion Control for Low-Cost Reliability, Held in Houston, Texas on September 19 -24, 1993. Volume 3A. Corrosion: Specific Issues.

    DTIC Science & Technology

    1993-09-24

    Environmental Safety - nad Irreconcilable Antagonism in the Chemical 097 Application of Electrochemical Impedance Spectroscopy to Study Process Industry the...195 569 Study of Enameling Properties on the Hot-RolledTi-Containing 044 Compatability of Organic Coatings with Flame Spraying...204 COATINGS METALLIC COATING AND SURFACE TREATMENTS 025 Study of Anticorrosion Properties

  14. Stripping and splicing polyimide-coated fibers

    NASA Astrophysics Data System (ADS)

    Duke, Douglas; Kanda, Yoshiharu; Tobita, Kenyo; Yamauchi, Ryozo

    2011-05-01

    Polyimide is often used as a coating material for optical fibers used in high temperature environments such as aerospace or oil and gas sensor applications. Unfortunately, polyimide coating is very difficult to strip by conventional mechanical stripping methods. The glass fiber is easily damaged if the stripping process is not extremely well controlled. Stripping the polyimide coating by heating with a flame or arc typically results in a significant reduction in fiber strength. Strength may be maintained by using hot acid stripping, however the use of the strong hot acid presents safety hazards and also requires controlled and safe waste disposal. Another issue with polyimide coating is variability of the coating diameter from various manufacturers or due to different polyimide coating processes. This not only complicates the polyimide stripping issue, but also presents problems with precise clamping and alignment during splicing, especially when it is necessary to splice with a short cleave length. In this paper, we present new polyimide coating stripping technology. The significant feature of this stripping technology is achievement of good strength while avoiding the use of hot acid or heating. We also developed a new specialty fiber fusion splicer that enables precise alignment and splicing regardless of the variability of polyimide coating diameter, even when clamping on the coating.

  15. Study for new hardmask process scheme

    NASA Astrophysics Data System (ADS)

    Lee, Daeyoup; Tatti, Phillip; Lee, Richard; Chang, Jack; Cho, Winston; Bae, Sanggil

    2017-03-01

    Hardmask processes are a key technique to enable low-k semiconductors, but they can have an impact on patterning control, influencing defectivity, alignment, and overlay. Specifically, amorphous carbon layer (ACL) hardmask schemes can negatively affect overlay by creating distorted alignment signals. A new scheme needs to be developed that can be inserted where amorphous carbon is used but provide better alignment performance. Typical spin-on carbon (SOC) materials used in other hardmask schemes have issues with DCD-FCD skew. In this paper we will evaluate new spin-on carbon material with a higher carbon content that could be a candidate to replace amorphous carbon.

  16. Experimental studies of breaking of elastic tired wheel under variable normal load

    NASA Astrophysics Data System (ADS)

    Fedotov, A. I.; Zedgenizov, V. G.; Ovchinnikova, N. I.

    2017-10-01

    The paper analyzes the braking of a vehicle wheel subjected to disturbances of normal load variations. Experimental tests and methods for developing test modes as sinusoidal force disturbances of the normal wheel load were used. Measuring methods for digital and analogue signals were used as well. Stabilization of vehicle wheel braking subjected to disturbances of normal load variations is a topical issue. The paper suggests a method for analyzing wheel braking processes under disturbances of normal load variations. A method to control wheel baking processes subjected to disturbances of normal load variations was developed.

  17. SWiFT Software Quality Assurance Plan.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Berg, Jonathan Charles

    This document describes the software development practice areas and processes which contribute to the ability of SWiFT software developers to provide quality software. These processes are designed to satisfy the requirements set forth by the Sandia Software Quality Assurance Program (SSQAP). APPROVALS SWiFT Software Quality Assurance Plan (SAND2016-0765) approved by: Department Manager SWiFT Site Lead Dave Minster (6121) Date Jonathan White (6121) Date SWiFT Controls Engineer Jonathan Berg (6121) Date CHANGE HISTORY Issue Date Originator(s) Description A 2016/01/27 Jon Berg (06121) Initial release of the SWiFT Software Quality Assurance Plan

  18. An overview of the on-orbit contamination of the Long Duration Exposure Facility (LDEF)

    NASA Technical Reports Server (NTRS)

    Stuckey, W. K.

    1993-01-01

    Contamination that leads to degradation of critical surfaces becomes a vital design issue for many spacecraft programs. One of the processes that must be considered is the on-orbit accumulation of contaminants. The Long Duration Exposure Facility (LDEF) has presented an opportunity to examine the deposits on surfaces returned from orbit in order to help in understanding the deposition processes and the current models used to predict spacecraft contamination levels. The results from various investigators on the contamination of LDEF have implications for material selection, contamination models, and contamination control plans for the design of future spacecraft.

  19. Multicutter machining of compound parametric surfaces

    NASA Astrophysics Data System (ADS)

    Hatna, Abdelmadjid; Grieve, R. J.; Broomhead, P.

    2000-10-01

    Parametric free forms are used in industries as disparate as footwear, toys, sporting goods, ceramics, digital content creation, and conceptual design. Optimizing tool path patterns and minimizing the total machining time is a primordial issue in numerically controlled (NC) machining of free form surfaces. We demonstrate in the present work that multi-cutter machining can achieve as much as 60% reduction in total machining time for compound sculptured surfaces. The given approach is based upon the pre-processing as opposed to the usual post-processing of surfaces for the detection and removal of interference followed by precise tracking of unmachined areas.

  20. Controlled ecological life support system - biological problems

    NASA Technical Reports Server (NTRS)

    Moore, B., III (Editor); Macelroy, R. D. (Editor)

    1982-01-01

    The general processes and controls associated with two distinct experimental paradigms are examined. Specific areas for research related to biotic production (food production) and biotic decomposition (waste management) are explored. The workshop discussions were directed toward Elemental cycles and the biological factors that affect the transformations of nutrients into food, of food material into waste, and of waste into nutrients were discussed. To focus on biological issues, the discussion assumed that (1) food production would be by biological means (thus excluding chemical synthesis), (2) energy would not be a limiting factor, and (3) engineering capacity for composition and leak rate would be adequate.

  1. Framing access to medicines in developing countries: an analysis of media coverage of Canada's Access to Medicines Regime

    PubMed Central

    2010-01-01

    Background In September 2003, the Canadian government committed to developing legislation that would facilitate greater access to affordable medicines for developing countries. Over the course of eight months, the legislation, now known as Canada's Access to Medicines Regime (CAMR), went through a controversial policy development process and the newspaper media was one of the major venues in which the policy debates took place. The purpose of this study was to examine how the media framed CAMR to determine how policy goals were conceptualized, which stakeholder interests controlled the public debate and how these variables related to the public policy process. Methods We conducted a qualitative content analysis of newspaper coverage of the CAMR policy and implementation process from 2003-2008. The primary theoretical framework for this study was framing theory. A total of 90 articles from 11 Canadian newspapers were selected for inclusion in our analysis. A team of four researchers coded the articles for themes relating to access to medicines and which stakeholders' voice figured more prominently on each issue. Stakeholders examined included: the research-based industry, the generic industry, civil society, the Canadian government, and developing country representatives. Results The most frequently mentioned themes across all documents were the issues of drug affordability, intellectual property, trade agreements and obligations, and development. Issues such as human rights, pharmaceutical innovation, and economic competitiveness got little media representation. Civil society dominated the media contents, followed far behind by the Canadian government, the research-based and generic pharmaceutical industries. Developing country representatives were hardly represented in the media. Conclusions Media framing obscured the discussion of some of the underlying policy goals in this case and failed to highlight issues which are now significant barriers to the use of the legislation. Using the media to engage the public in more in-depth exploration of the policy issues at stake may contribute to a more informed policy development process. The media can be an effective channel for those stakeholders with a weaker voice in policy deliberations to raise public attention to particular issues; however, the political and institutional context must be taken into account as it may outweigh media framing effects. PMID:20044940

  2. Status of food irradiation in the United States

    NASA Astrophysics Data System (ADS)

    Derr, Donald D.; Engel, Ronald E.

    1993-07-01

    The time immediately preceding the 8th International Meeting on Radiation Processing in September 1992 has been a landmark period for food irradiation in the United States. U.S. regulatory officials, industry and media representatives, and some consumer organizations share the opinion that radiation processing may be part of the solution to microbiological contamination of products of animal origin. Several new regulations being developed by U.S. regulatory agencies and being petitioned by industry groups are outlined. Renewed interest on the part of the U.S. Army in using irradiated foods in many of their nations is reviewed. The first commercial facility designed for food irradiation and two demonstration food irradiation facilities began operations early in 1992. The progress of these facilities is discussed. The North American Free Trade Agreement (NAFTA) and the Uruguay round of GATT negotiations may significantly lower barriers that impede international agricultural trade. International agreement on appropriate control and inspection procedures would eliminate unnecessary differences and improve mutual trust thus facilitating international trade in irradiated foods. The harmonization of radiation process practices, dosimetry standards, and other issues plays a very important role in meeting the provisions of trade agreeements. It is vitally important to address these issues early in the commercialization of food irradiation throughout the trading world. Some comments in that area are provided. Much has been done already to harmonize regulations and facilitate trade; but there is still much to be done. Regardless of how these issues are resolved, they will have a significant impact on the use of radiation processing for foods and the trade of irradiated foods all over the world.

  3. 49 CFR 106.10 - Process for issuing rules.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... filing written comments or making oral presentations). (4) Whom to call if you have questions about the... 49 Transportation 2 2010-10-01 2010-10-01 false Process for issuing rules. 106.10 Section 106.10... PHMSA Rulemaking Documents § 106.10 Process for issuing rules. (a) PHMSA (“we”) uses informal rulemaking...

  4. Malaria eradication: the economic, financial and institutional challenge.

    PubMed

    Mills, Anne; Lubell, Yoel; Hanson, Kara

    2008-12-11

    Malaria eradication raises many economic, financial and institutional challenges. This paper reviews these challenges, drawing on evidence from previous efforts to eradicate malaria, with a special focus on resource-poor settings; summarizes more recent evidence on the challenges, drawing on the literature on the difficulties of scaling-up malaria control and strengthening health systems more broadly; and explores the implications of these bodies of evidence for the current call for elimination and intensified control. Economic analyses dating from the eradication era, and more recent analyses, suggest that, in general, the benefits of malaria control outweigh the costs, though few studies have looked at the relative returns to eradication versus long-term control. Estimates of financial costs are scanty and difficult to compare. In the 1960s, the consolidation phase appeared to cost less than $1 per capita and, in 1988, was estimated to be $2.31 per capita (both in 2006 prices). More recent estimates for high coverage of control measures suggest a per capita cost of several dollars. Institutional challenges faced by malaria eradication included limits to the rule of law (a major problem where malaria was concentrated in border areas with movement of people associated with illegal activities), the existence and performance of local implementing structures, and political sustainability at national and global levels. Recent analyses of the constraints to scaling-up malaria control, together with the historical evidence, are used to discuss the economic, financial and institutional challenges that face the renewed call for eradication and intensified control. The paper concludes by identifying a research agenda covering: issues of the allocative efficiency of malaria eradication, especially using macro-economic modelling to estimate the benefits and costs of malaria eradication and intensified control, and studies of the links between malaria control and economic development, the costs and consequences of the various tools and mixes of tools employed in control and eradication, issues concerning the extension of coverage of interventions and service delivery approaches, especially those that can reach the poorest, research on the processes of formulating and implementing malaria control and eradication policies, at both international and national levels, research on financing issues, at global and national levels.

  5. The development of Tobacco Harm Prevention Law in Vietnam: stakeholder tensions over tobacco control legislation in a state owned industry

    PubMed Central

    2011-01-01

    Background Building on its National Tobacco Control Policy initiated in 2000, Vietnam is currently considering introducing a comprehensive law to strengthen the implementation of tobacco control policy. This study analyses the positions of key stakeholders in the development of tobacco control legislation in the context of a largely state-owned industry, and discusses their implications for the policy process. Methods Several qualitative methods were employed for the study including: literature review and documentary analysis; key informant interview; focus groups discussion; and key stakeholders survey. Findings The Ministry of Health, Ministry of Trade and Industry, and Ministry of Finance are key players in the tobacco control policy and legislation, representing competing bureaucratic interests over health, macro-economy and revenue. High-ranking officials, including the Communist Party and National Assembly members, take a rather relaxed position reflecting the low political stakes placed on tobacco issues. The state-owned tobacco industry is regarded as an important contributor to the government revenue and gross domestic product, and the relative weight on health and socioeconomic issues placed by stakeholders determine their positions on tobacco control. Overall, short-term economic interests have more immediate influence in setting policy directions, with the consequences of health gains perceived as relegated to a distant future. This was reflected in the position of tobacco control advocates, including MOH, that presented with reluctance in insisting on some tobacco control strategies revealing a mixture attitude of concessions to the socioeconomic uncertainties and a sense of bargaining to win the strategies that are more likely to be accepted. Conclusion The state-ownership of tobacco industry poses a major paradox within the government that benefits from manufacturing of tobacco products and is also responsible for controlling tobacco consumption. The perceptions of negative implications on government revenue and the macro-economy, coupled with the reluctance to challenge these issues from health perspective too directly, means that tobacco control has yet to secure itself a place on the priority policy agenda. The overall policy environment will shift in favour of tobacco control only if the economic framing can be challenged. PMID:21923945

  6. Malaria eradication: the economic, financial and institutional challenge

    PubMed Central

    Mills, Anne; Lubell, Yoel; Hanson, Kara

    2008-01-01

    Malaria eradication raises many economic, financial and institutional challenges. This paper reviews these challenges, drawing on evidence from previous efforts to eradicate malaria, with a special focus on resource-poor settings; summarizes more recent evidence on the challenges, drawing on the literature on the difficulties of scaling-up malaria control and strengthening health systems more broadly; and explores the implications of these bodies of evidence for the current call for elimination and intensified control. Economic analyses dating from the eradication era, and more recent analyses, suggest that, in general, the benefits of malaria control outweigh the costs, though few studies have looked at the relative returns to eradication versus long-term control. Estimates of financial costs are scanty and difficult to compare. In the 1960s, the consolidation phase appeared to cost less than $1 per capita and, in 1988, was estimated to be $2.31 per capita (both in 2006 prices). More recent estimates for high coverage of control measures suggest a per capita cost of several dollars. Institutional challenges faced by malaria eradication included limits to the rule of law (a major problem where malaria was concentrated in border areas with movement of people associated with illegal activities), the existence and performance of local implementing structures, and political sustainability at national and global levels. Recent analyses of the constraints to scaling-up malaria control, together with the historical evidence, are used to discuss the economic, financial and institutional challenges that face the renewed call for eradication and intensified control. The paper concludes by identifying a research agenda covering: ∘ issues of the allocative efficiency of malaria eradication, especially using macro-economic modelling to estimate the benefits and costs of malaria eradication and intensified control, and studies of the links between malaria control and economic development ∘ the costs and consequences of the various tools and mixes of tools employed in control and eradication ∘ issues concerning the extension of coverage of interventions and service delivery approaches, especially those that can reach the poorest ∘ research on the processes of formulating and implementing malaria control and eradication policies, at both international and national levels ∘ research on financing issues, at global and national levels. PMID:19091035

  7. The development of Tobacco Harm Prevention Law in Vietnam: stakeholder tensions over tobacco control legislation in a state owned industry.

    PubMed

    Higashi, Hideki; Khuong, Tuan A; Ngo, Anh D; Hill, Peter S

    2011-09-18

    Building on its National Tobacco Control Policy initiated in 2000, Vietnam is currently considering introducing a comprehensive law to strengthen the implementation of tobacco control policy. This study analyses the positions of key stakeholders in the development of tobacco control legislation in the context of a largely state-owned industry, and discusses their implications for the policy process. Several qualitative methods were employed for the study including: literature review and documentary analysis; key informant interview; focus groups discussion; and key stakeholders survey. The Ministry of Health, Ministry of Trade and Industry, and Ministry of Finance are key players in the tobacco control policy and legislation, representing competing bureaucratic interests over health, macro-economy and revenue. High-ranking officials, including the Communist Party and National Assembly members, take a rather relaxed position reflecting the low political stakes placed on tobacco issues. The state-owned tobacco industry is regarded as an important contributor to the government revenue and gross domestic product, and the relative weight on health and socioeconomic issues placed by stakeholders determine their positions on tobacco control. Overall, short-term economic interests have more immediate influence in setting policy directions, with the consequences of health gains perceived as relegated to a distant future. This was reflected in the position of tobacco control advocates, including MOH, that presented with reluctance in insisting on some tobacco control strategies revealing a mixture attitude of concessions to the socioeconomic uncertainties and a sense of bargaining to win the strategies that are more likely to be accepted. The state-ownership of tobacco industry poses a major paradox within the government that benefits from manufacturing of tobacco products and is also responsible for controlling tobacco consumption. The perceptions of negative implications on government revenue and the macro-economy, coupled with the reluctance to challenge these issues from health perspective too directly, means that tobacco control has yet to secure itself a place on the priority policy agenda. The overall policy environment will shift in favour of tobacco control only if the economic framing can be challenged.

  8. To Punish or to Leave: Distinct Cognitive Processes Underlie Partner Control and Partner Choice Behaviors

    PubMed Central

    Martin, Justin W.; Cushman, Fiery

    2015-01-01

    When a cooperative partner defects, at least two types of response are available: Punishment, aimed at modifying behavior, and ostracism, aimed at avoiding further social interaction with the partner. These options, termed partner control and partner choice, have been distinguished at behavioral and evolutionary levels. However, little work has compared their cognitive bases. Do these disparate behaviors depend on common processes of moral evaluation? Specifically, we assess whether they show identical patterns of dependence on two key dimensions of moral evaluation: A person’s intentions, and the outcomes that they cause. We address this issue in a “trembling hand” economic game. In this game, an allocator divides a monetary stake between themselves and a responder based on a stochastic mechanism. This allows for dissociations between the allocator’s intent and the actual outcome. Responders were either given the opportunity to punish or reward the allocator (partner control) or to switch to a different partner for a subsequent round of play (partner choice). Our results suggest that partner control and partner choice behaviors are supported by distinct underlying cognitive processes: Partner control exhibits greater sensitivity to the outcomes a partner causes, while partner choice is influenced almost exclusively by a partner’s intentions. This cognitive dissociation can be understood in light of the unique adaptive functions of partner control and partner choice. PMID:25915550

  9. A Multifaceted Approach to Modernizing NASA's Advanced Multi-Mission Operations System (AMMOS) System Architecture

    NASA Technical Reports Server (NTRS)

    Estefan, Jeff A.; Giovannoni, Brian J.

    2014-01-01

    The Advanced Multi-Mission Operations Systems (AMMOS) is NASA's premier space mission operations product line offering for use in deep-space robotic and astrophysics missions. The general approach to AMMOS modernization over the course of its 29-year history exemplifies a continual, evolutionary approach with periods of sponsor investment peaks and valleys in between. Today, the Multimission Ground Systems and Services (MGSS) office-the program office that manages the AMMOS for NASA-actively pursues modernization initiatives and continues to evolve the AMMOS by incorporating enhanced capabilities and newer technologies into its end-user tool and service offerings. Despite the myriad of modernization investments that have been made over the evolutionary course of the AMMOS, pain points remain. These pain points, based on interviews with numerous flight project mission operations personnel, can be classified principally into two major categories: 1) information-related issues, and 2) process-related issues. By information-related issues, we mean pain points associated with the management and flow of MOS data across the various system interfaces. By process-related issues, we mean pain points associated with the MOS activities performed by mission operators (i.e., humans) and supporting software infrastructure used in support of those activities. In this paper, three foundational concepts-Timeline, Closed Loop Control, and Separation of Concerns-collectively form the basis for expressing a set of core architectural tenets that provides a multifaceted approach to AMMOS system architecture modernization intended to address the information- and process-related issues. Each of these architectural tenets will be further explored in this paper. Ultimately, we envision the application of these core tenets resulting in a unified vision of a future-state architecture for the AMMOS-one that is intended to result in a highly adaptable, highly efficient, and highly cost-effective set of multimission MOS products and services.

  10. Contribution au developpement d'une methode de controle des procedes dans une usine de bouletage

    NASA Astrophysics Data System (ADS)

    Gosselin, Claude

    This thesis, a collaborative effort between Ecole de technologie superieure and ArcelorMittal Company, presents the development of a methodology for monitoring and quality control of multivariable industrial production processes. This innovation research mandate was developed at ArcelorMittal Exploitation Miniere (AMEM) pellet plant in Port-Cartier (Quebec, Canada). With this undertaking, ArcelorMittal is striving to maintain its world class level of excellence and continues to pursue initiatives that can augment its competitive advantage worldwide. The plant's gravimetric classification process was retained as a prototype and development laboratory due to its effect on the company's competitiveness and its impact on subsequent steps leading to final production of iron oxide pellets. Concretely, the development of this expertise in process control and in situ monitoring will establish a firm basic knowledge in the fields of complex system physical modeling, data reconciliation, statistical observers, multivariate command and quality control using real-time monitoring of the desirability function. The hydraulic classifier is mathematically modeled. Using planned disturbances on the production line, an identification procedure was established to provide empirical estimations of the model's structural parameters. A new sampling campaign and a previously unpublished data collection and consolidation policy were implemented plant-wide. Access to these invaluable data sources has enabled the establishment of new thresholds that govern the production process and its control. Finally, as a substitute for the traditional quality control process, we have implemented a new strategy based on the use of the desirability function. Our innovation is not in using this Finally, as a substitute for the traditional quality control process, we have implemented a new strategy based on the use of the desirability function. Our innovation is not in using this function as an indicator of overall (economic) satisfaction in the production process, but rather in proposing it as an "observer" of the system's state. The first implementation steps have already demonstrated the method's feasibility as well as other numerous industrial impacts on production processes within the company. Namely, the emergence of the economical aspect as a strategic variable that assures better governance of production processes where quality variables present strategic issues.

  11. Transfer of control system interface solutions from other domains to the thermal power industry.

    PubMed

    Bligård, L-O; Andersson, J; Osvalder, A-L

    2012-01-01

    In a thermal power plant the operators' roles are to control and monitor the process to achieve efficient and safe production. To achieve this, the human-machine interfaces have a central part. The interfaces need to be updated and upgraded together with the technical functionality to maintain optimal operation. One way of achieving relevant updates is to study other domains and see how they have solved similar issues in their design solutions. The purpose of this paper is to present how interface design solution ideas can be transferred from domains with operator control to thermal power plants. In the study 15 domains were compared using a model for categorisation of human-machine systems. The result from the domain comparison showed that nuclear power, refinery and ship engine control were most similar to thermal power control. From the findings a basic interface structure and three specific display solutions were proposed for thermal power control: process parameter overview, plant overview, and feed water view. The systematic comparison of the properties of a human-machine system allowed interface designers to find suitable objects, structures and navigation logics in a range of domains that could be transferred to the thermal power domain.

  12. The moderating effect of motivation on health-related decision-making.

    PubMed

    Berezowska, Aleksandra; Fischer, Arnout R H; Trijp, Hans C M van

    2017-06-01

    This study identifies how autonomous and controlled motivation moderates the cognitive process that drives the adoption of personalised nutrition services. The cognitive process comprises perceptions of privacy risk, personalisation benefit, and their determinants. Depending on their level of autonomous and controlled motivation, participants (N = 3453) were assigned to one of four motivational orientations, which resulted in a 2 (low/high autonomous motivation) × 2 (low/high controlled motivation) quasi-experimental design. High levels of autonomous motivation strengthened the extent to which: (1) the benefits of engaging with a service determined the outcome of a risk-benefit trade-off; (2) the effectiveness of a service determined benefit perceptions. High levels of controlled motivation influenced the extent to which: (1) the risk of privacy loss determined the outcome of a risk-benefit trade-off; (2) controlling personal information after disclosure and perceiving the disclosed personal information as sensitive determined the risk of potential privacy loss. To encourage the adoption of personalised dietary recommendations, for individuals with high levels of autonomous motivation emphasis should be on benefits and its determinants. For those with high levels of controlled motivation, it is important to focus on risk-related issues such as information sensitivity.

  13. Digital mapping of the Mars Pathfinder landing site: Design, acquisition, and derivation of cartographic products for science applications

    USGS Publications Warehouse

    Gaddis, L.R.; Kirk, R.L.; Johnson, J. R.; Soderblom, L.A.; Ward, A.W.; Barrett, J.; Becker, K.; Decker, T.; Blue, J.; Cook, D.; Eliason, E.; Hare, T.; Howington-Kraus, E.; Isbell, C.; Lee, E.M.; Redding, B.; Sucharski, R.; Sucharski, T.; Smith, P.H.; Britt, D.T.

    1999-01-01

    The Imager for Mars Pathfinder (IMP) acquired more than 16,000 images and provided panoramic views of the surface of Mars at the Mars Pathfinder landing site in Ares Vallis. This paper describes the stereoscopic, multispectral IMP imaging sequences and focuses on their use for digital mapping of the landing site and for deriving cartographic products to support science applications of these data. Two-dimensional cartographic processing of IMP data, as performed via techniques and specialized software developed for ISIS (the U.S.Geological Survey image processing software package), is emphasized. Cartographic processing of IMP data includes ingestion, radiometric correction, establishment of geometric control, coregistration of multiple bands, reprojection, and mosaicking. Photogrammetric processing, an integral part of this cartographic work which utilizes the three-dimensional character of the IMP data, supplements standard processing with geometric control and topographic information [Kirk et al., this issue]. Both cartographic and photogrammetric processing are required for producing seamless image mosaics and for coregistering the multispectral IMP data. Final, controlled IMP cartographic products include spectral cubes, panoramic (360?? azimuthal coverage) and planimetric (top view) maps, and topographic data, to be archived on four CD-ROM volumes. Uncontrolled and semicontrolled versions of these products were used to support geologic characterization of the landing site during the nominal and extended missions. Controlled products have allowed determination of the topography of the landing site and environs out to ???60 m, and these data have been used to unravel the history of large- and small-scale geologic processes which shaped the observed landing site. We conclude by summarizing several lessons learned from cartographic processing of IMP data. Copyright 1999 by the American Geophysical Union.

  14. Is there a role for a test controller in the development of new ATC equipment?

    NASA Technical Reports Server (NTRS)

    Westrum, Ron

    1994-01-01

    Earl Wiener points out that human factors problems fixed during the R & D stage are paid for once. When they are not fixed during R & D, they are then paid for every day. How users are involved in the R & D process to assist in developing equipment is a critical issue. Effective involvement can produce real improvements. Ineffective involvement can produce inefficient kludges or systems that are actually dangerous. The underlying problem is the management of information and ideas. To develop a really generative system a great deal would have to change in the way that the FAA innovates. Use of test controllers would solve only some of the problems. For instance, we have cockpit resource management now for pilots; we may have it soon for controllers. But the management of ideas in the innovation process also needs intellectual resource management. Simply involving users is not enough. Brought in at the wrong point in the development process, users can block or compromise innovation. User involvement must be carefully considered. A test controller may be one solution to this problem. It might be necessary to have several kinds of test controllers (en route versus TRACON, for instance). No doubt further problems would surface in getting test controllers into operation. I would recommend that the FAA engage in a series of case studies of controller involvement in the innovation process. A systematic comparison of effective and ineffective cases would do much to clarify what we ought to do in the future. Unfortunately, I have been unable to find any cases where test controllers have been used. Perhaps we need to create some, to see how they work.

  15. The neural processing of moral sensitivity to issues of justice and care.

    PubMed

    Robertson, Diana; Snarey, John; Ousley, Opal; Harenski, Keith; DuBois Bowman, F; Gilkey, Rick; Kilts, Clinton

    2007-03-02

    The empirical and theoretical consideration of ethical decision making has focused on the process of moral judgment; however, a precondition to judgment is moral sensitivity, the ability to detect and evaluate moral issues [Rest, J. R. (1984). The major components of morality. In W. Kurtines & J. Gewirtz (Eds.), Morality, moral behaviour, and moral development (pp. 24-38). New York, NY: Wiley]. Using functional magnetic resonance imaging (fMRI) and contextually standardized, real life moral issues, we demonstrate that sensitivity to moral issues is associated with activation of the polar medial prefrontal cortex, dorsal posterior cingulate cortex, and posterior superior temporal sulcus (STS). These activations suggest that moral sensitivity is related to access to knowledge unique to one's self, supported by autobiographical memory retrieval and social perspective taking. We also assessed whether sensitivity to rule-based or "justice" moral issues versus social situational or "care" moral issues is associated with dissociable neural processing events. Sensitivity to justice issues was associated with greater activation of the left intraparietal sulcus, whereas sensitivity to care issues was associated with greater activation of the ventral posterior cingulate cortex, ventromedial and dorsolateral prefrontal cortex, and thalamus. These results suggest a role for access to self histories and identities and social perspectives in sensitivity to moral issues, provide neural representations of the subcomponent process of moral sensitivity originally proposed by Rest, and support differing neural information processing for the interpretive recognition of justice and care moral issues.

  16. Coasts: the ethical dimension.

    PubMed

    Olsen, S; Hale, L Z

    1994-01-01

    Rapidly increasing numbers of people are profoundly altering the very qualities of coastal regions that make them the preferred home for the majority of the world's population. Along with masses of people, coastal areas contain a high proportion of the world's productive and diverse ecosystems, produce most of the world's fish catch, and support major portions of the world's agriculture, industry, and tourism. Over years of development, changes have been noted to local environments. Along coastlines, global change is manifested in terms of major shifts in rainfall patterns, an increase in the number of violent and destructive storms, and a rise in sea level. However, much of the degradation and conflict noted is considered avoidable and unnecessary. National coastal management programs should prioritize bringing order and control to the process of change and consider equity issues in the development process. Moreover, a ¿two-track approach¿, which uses local-level demonstration projects to discover, test, and apply innovative governance and technical solutions to the complex matrix of coastal management issues, is recommended.

  17. Design of a liquid membrane target for high repetition rate neutron generation

    NASA Astrophysics Data System (ADS)

    Poole, Patrick; Andereck, C. David; Storm, Mike; Schumacher, Douglass

    2013-10-01

    Ultra-bright, pulsed, spatially-small sources of energetic neutrons have applications in radiography and non-destructive remote sensing. Neutrons can be generated by a process wherein ions accelerated from a laser-irradiated primary target subsequently bombard a converter material, causing neutron-producing nuclear reactions, such as 7Li(d,n)8Be. Deuterons from this process are suppressed by contamination that builds up on the rear of the solid primary target. To eliminate this issue we propose a self-replenishing liquid membrane target consisting of heavy water and deuterated surfactant, formed in-vacuum within a moveable wire frame. In addition to removing issues associated with solid target positioning and collateral damage, this apparatus provides flow rate and target thickness control, and allows for the high repetition rates required to generate desired neutron fluxes with a portable laser-based system. The apparatus design will be presented, as well as a novel interferometric method that measures the membrane thickness using tightly-focused light. This work was performed with support from DARPA.

  18. Advanced integrated enhanced vision systems

    NASA Astrophysics Data System (ADS)

    Kerr, J. R.; Luk, Chiu H.; Hammerstrom, Dan; Pavel, Misha

    2003-09-01

    In anticipation of its ultimate role in transport, business and rotary wing aircraft, we clarify the role of Enhanced Vision Systems (EVS): how the output data will be utilized, appropriate architecture for total avionics integration, pilot and control interfaces, and operational utilization. Ground-map (database) correlation is critical, and we suggest that "synthetic vision" is simply a subset of the monitor/guidance interface issue. The core of integrated EVS is its sensor processor. In order to approximate optimal, Bayesian multi-sensor fusion and ground correlation functionality in real time, we are developing a neural net approach utilizing human visual pathway and self-organizing, associative-engine processing. In addition to EVS/SVS imagery, outputs will include sensor-based navigation and attitude signals as well as hazard detection. A system architecture is described, encompassing an all-weather sensor suite; advanced processing technology; intertial, GPS and other avionics inputs; and pilot and machine interfaces. Issues of total-system accuracy and integrity are addressed, as well as flight operational aspects relating to both civil certification and military applications in IMC.

  19. SOXAL{trademark} pilot plant demonstration at Niagara Mohawk`s Dunkirk Station

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Strangway, P.K.

    The Clean Air Act Amendments of 1990 made it necessary to accelerate the development of scrubber systems for use by some utilities burning sulfur-containing fuels, primarily coal. While many types of Flue Gas Desulfurization (FGD) systems operate based on lime and limestone scrubbing, these systems have drawbacks when considered for incorporation into long-term emissions control plans. Although the costs associated with disposal of large amounts of scrubber sludge may be manageable today, the trend is toward increased disposal costs. Many new SO{sub 2} control technologies are being pursued in the hope of developing an economical regenerable FGD system did recoversmore » the SO{sub 2} as a saleable commercial product, thus minimizing the formation of disposal waste. Some new technologies include the use of exotic chemical absorbents which are alien to the utility industry and utilities` waste treatment facilities. These systems present utilities with new environmental issues. The SOXAL{trademark} process has been developed so as to eliminate such issues.« less

  20. Ethical aspects of malaria control and research.

    PubMed

    Jamrozik, Euzebiusz; de la Fuente-Núñez, Vânia; Reis, Andreas; Ringwald, Pascal; Selgelid, Michael J

    2015-12-22

    Malaria currently causes more harm to human beings than any other parasitic disease, and disproportionally affects low-income populations. The ethical issues raised by efforts to control or eliminate malaria have received little explicit analysis, in comparison with other major diseases of poverty. While some ethical issues associated with malaria are similar to those that have been the subject of debate in the context of other infectious diseases, malaria also raises distinct ethical issues in virtue of its unique history, epidemiology, and biology. This paper provides preliminary ethical analyses of the especially salient issues of: (i) global health justice, (ii) universal access to malaria control initiatives, (iii) multidrug resistance, including artemisinin-based combination therapy (ACT) resistance, (iv) mandatory screening, (v) mass drug administration, (vi) benefits and risks of primaquine, and (vii) malaria in the context of blood donation and transfusion. Several ethical issues are also raised by past, present and future malaria research initiatives, in particular: (i) controlled infection studies, (ii) human landing catches, (iii) transmission-blocking vaccines, and (iv) genetically-modified mosquitoes. This article maps the terrain of these major ethical issues surrounding malaria control and elimination. Its objective is to motivate further research and discussion of ethical issues associated with malaria--and to assist health workers, researchers, and policy makers in pursuit of ethically sound malaria control practice and policy.

  1. 10 CFR 708.30 - What process does the Hearing Officer follow to issue an initial agency decision?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... initial agency decision? 708.30 Section 708.30 Energy DEPARTMENT OF ENERGY DOE CONTRACTOR EMPLOYEE PROTECTION PROGRAM Investigation, Hearing and Decision Process § 708.30 What process does the Hearing Officer follow to issue an initial agency decision? (a) The Hearing Officer will issue an initial agency decision...

  2. Offline modeling for product quality prediction of mineral processing using modeling error PDF shaping and entropy minimization.

    PubMed

    Ding, Jinliang; Chai, Tianyou; Wang, Hong

    2011-03-01

    This paper presents a novel offline modeling for product quality prediction of mineral processing which consists of a number of unit processes in series. The prediction of the product quality of the whole mineral process (i.e., the mixed concentrate grade) plays an important role and the establishment of its predictive model is a key issue for the plantwide optimization. For this purpose, a hybrid modeling approach of the mixed concentrate grade prediction is proposed, which consists of a linear model and a nonlinear model. The least-squares support vector machine is adopted to establish the nonlinear model. The inputs of the predictive model are the performance indices of each unit process, while the output is the mixed concentrate grade. In this paper, the model parameter selection is transformed into the shape control of the probability density function (PDF) of the modeling error. In this context, both the PDF-control-based and minimum-entropy-based model parameter selection approaches are proposed. Indeed, this is the first time that the PDF shape control idea is used to deal with system modeling, where the key idea is to turn model parameters so that either the modeling error PDF is controlled to follow a target PDF or the modeling error entropy is minimized. The experimental results using the real plant data and the comparison of the two approaches are discussed. The results show the effectiveness of the proposed approaches.

  3. HealthLines: Control Blood Pressure, Protect Your Kidneys

    MedlinePlus

    ... Home Current Issue Past Issues Health Lines Control Blood Pressure, Protect Your Kidneys Past Issues / Fall 2008 Table ... on. By Shana Potash, Staff Writer, NLM High blood pressure is a leading cause of chronic kidney disease ( ...

  4. Mathematical modelling of active safety system functions as tools for development of driverless vehicles

    NASA Astrophysics Data System (ADS)

    Ryazantsev, V.; Mezentsev, N.; Zakharov, A.

    2018-02-01

    This paper is dedicated to a solution of the issue of synthesis of the vehicle longitudinal dynamics control functions (acceleration and deceleration control) based on the element base of the vehicle active safety system (ESP) - driverless vehicle development tool. This strategy helps to reduce time and complexity of integration of autonomous motion control systems (AMCS) into the vehicle architecture and allows direct control of actuators ensuring the longitudinal dynamics control, as well as reduction of time for calibration works. The “vehicle+wheel+road” longitudinal dynamics control is complicated due to the absence of the required prior information about the control object. Therefore, the control loop becomes an adaptive system, i.e. a self-adjusting monitoring system. Another difficulty is the driver’s perception of the longitudinal dynamics control process in terms of comfort. Traditionally, one doesn’t pay a lot of attention to this issue within active safety systems, and retention of vehicle steerability, controllability and stability in emergency situations are considered to be the quality criteria. This is mainly connected to its operational limits, since it is activated only in critical situations. However, implementation of the longitudinal dynamics control in the AMCS poses another challenge for the developers - providing the driver with comfortable vehicle movement during acceleration and deceleration - while the possible highest safety level in terms of the road grip is provided by the active safety system (ESP). The results of this research are: universal active safety system - AMCS interaction interface; block diagram for the vehicle longitudinal acceleration and deceleration control as one of the active safety system’s integrated functions; ideology of adaptive longitudinal dynamics control, which enables to realize the deceleration and acceleration requested by the AMCS; algorithms synthesised; analytical experiments proving the efficiency and practicability of the chosen concept.

  5. Design of freeze-drying processes for pharmaceuticals: practical advice.

    PubMed

    Tang, Xiaolin; Pikal, Michael J

    2004-02-01

    Design of freeze-drying processes is often approached with a "trial and error" experimental plan or, worse yet, the protocol used in the first laboratory run is adopted without further attempts at optimization. Consequently, commercial freeze-drying processes are often neither robust nor efficient. It is our thesis that design of an "optimized" freeze-drying process is not particularly difficult for most products, as long as some simple rules based on well-accepted scientific principles are followed. It is the purpose of this review to discuss the scientific foundations of the freeze-drying process design and then to consolidate these principles into a set of guidelines for rational process design and optimization. General advice is given concerning common stability issues with proteins, but unusual and difficult stability issues are beyond the scope of this review. Control of ice nucleation and crystallization during the freezing step is discussed, and the impact of freezing on the rest of the process and final product quality is reviewed. Representative freezing protocols are presented. The significance of the collapse temperature and the thermal transition, denoted Tg', are discussed, and procedures for the selection of the "target product temperature" for primary drying are presented. Furthermore, guidelines are given for selection of the optimal shelf temperature and chamber pressure settings required to achieve the target product temperature without thermal and/or mass transfer overload of the freeze dryer. Finally, guidelines and "rules" for optimization of secondary drying and representative secondary drying protocols are presented.

  6. A 3D bioprinting exemplar of the consequences of the regulatory requirements on customized processes.

    PubMed

    Hourd, Paul; Medcalf, Nicholas; Segal, Joel; Williams, David J

    2015-01-01

    Computer-aided 3D printing approaches to the industrial production of customized 3D functional living constructs for restoration of tissue and organ function face significant regulatory challenges. Using the manufacture of a customized, 3D-bioprinted nasal implant as a well-informed but hypothetical exemplar, we examine how these products might be regulated. Existing EU and USA regulatory frameworks do not account for the differences between 3D printing and conventional manufacturing methods or the ability to create individual customized products using mechanized rather than craft approaches. Already subject to extensive regulatory control, issues related to control of the computer-aided design to manufacture process and the associated software system chain present additional scientific and regulatory challenges for manufacturers of these complex 3D-bioprinted advanced combination products.

  7. Empirical Research on Spatial Diffusion Process of Knowledge Spillovers

    NASA Astrophysics Data System (ADS)

    Jin, Xuehui

    2018-02-01

    Firstly, this paper gave a brief review of the core issues of previous studies on spatial distribution of knowledge spillovers. That laid the theoretical foundation for further research. Secondly, this paper roughly described the diffusion process of solar patents in Bejing-Tianjin-Hebei and the Pearl River Delta regions by means of correlation analysis based on patent information of the application date and address of patentee. After that, this paper introduced the variables of spatial distance, knowledge absorptive capacity, knowledge gap and pollution control and built the empirical model of patent, and then collecting data to test them. The results showed that knowledge absorptive capacity was the most significant factor than the other three, followed by the knowledge gap. The influence of spatial distance on knowledge spillovers was limited and the most weak influence factor was pollution control.

  8. "Quitting like a Turk:" How political priority developed for tobacco control in Turkey.

    PubMed

    Hoe, Connie; Rodriguez, Daniela C; Üzümcüoğlu, Yeşim; Hyder, Adnan A

    2016-09-01

    In recent years, tobacco control emerged as a political priority in Turkey and today the country is widely regarded as one of the global leaders in tackling tobacco use. Although political priority is considered a facilitating factor to the success of addressing public health issues, there is a paucity of research to help us understand how it is developed in middle-income countries. The primary aim of this study is to understand the process and determinants of how tobacco control became a political priority in Turkey using the Multiple Streams Framework. A mixed-methods case study approach was used whereby data were gathered from three different sources: in-depth interviews (N = 19), document reviews (N = 216), and online self-administered surveys (N = 61). Qualitative data were collected for the purpose of understanding the processes and determinants that led to political prioritization of tobacco control and were analyzed using deductive and inductive coding. Quantitative data were collected to examine the actors and were analyzed using descriptive statistics and network nominations. Data were triangulated. Findings revealed that tobacco control achieved political priority in Turkey as a result of the development and convergence of multiple streams, including a fourth, separate global stream. Findings also shed light on the importance of Turkey's foreign policy in the transformation of the political stream. The country's desire for European Union accession and global visibility helped generate a political environment that was receptive to global norms for tobacco control. A diverse but cohesive network of actors joined forces with global allies to capitalize on this opportunity. Results suggest (1) the importance of global-agenda setting activities on political priority development, (2) the utility of aligning public health and foreign policy goals and (3) the need to build a strong global incentive structure to help entice governments to take action on public health issues. Copyright © 2016 Elsevier Ltd. All rights reserved.

  9. Robust Agent Control of an Autonomous Robot with Many Sensors and Actuators

    DTIC Science & Technology

    1993-05-01

    Overview 22 3.1 Issues of Controller Design ........................ 22 3.2 Robot Behavior Control Philosophy .................. 23 3.3 Overview of the... designed and built by our lab as an 9 Figure 1.1- Hannibal. 10 experimental platform to explore planetary micro-rover control issues (Angle 1991). When... designing the robot, careful consideration was given to mobility, sensing, and robustness issues. Much has been said concerning the advan- tages of

  10. Intelligence and arms control - a marriage of convenience

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hirschfeld, T.J.

    1987-01-01

    This book offers the first comprehensive look at how the vast US intelligence network enables negotiators to forge viable arms control agreements. The intelligence role in all three phases of the arms control process is discussed - from the design phase when reliable information is needed, to the execution phase when proposals are modified, to the maintenance phase when agreed-upon obligations begin to constrain adversary behavior and compliance becomes the key political issue. Contributors include: former CIA Director William E. Colby; Douglas George, Chief of the CIA's Control Intelligence Staff, Admiral Bobby R. Inman, former NSA Director; Hans Mark, formermore » Air Force Secretary and NSA administrator; Walt W. Rostow, National Security Adviser to President Johnson; and Paul Warnke, former Director of the Arms Control and Disarmament Agency and Chief Negotiator for SALT II.« less

  11. Detection and enforcement of failure-to-yield in an emergency vehicle preemption system

    NASA Technical Reports Server (NTRS)

    Bachelder, Aaron (Inventor); Wickline, Richard (Inventor)

    2007-01-01

    An intersection controlled by an intersection controller receives trigger signals from on-coming emergency vehicles responding to an emergency call. The intersection controller initiates surveillance of the intersection via cameras installed at the intersection in response to a received trigger signal. The surveillance may begin immediately upon receipt of the trigger signal from an emergency vehicle, or may wait until the intersection controller determines that the signaling emergency vehicle is in the field of view of the cameras at the intersection. Portions of the captured images are tagged by the intersection controller based on tag signals transmitted by the vehicle or based on detected traffic patterns that indicate a potential traffic violation. The captured images are downloaded to a processing facility that analyzes the images and automatically issues citations for captured traffic violations.

  12. Contamination Control and Hardware Processing Solutions at Marshall Space Flight Center

    NASA Technical Reports Server (NTRS)

    Burns, DeWitt H.; Hampton, Tammy; Huey, LaQuieta; Mitchell, Mark; Norwood, Joey; Lowrey, Nikki

    2012-01-01

    The Contamination Control Team of Marshall Space Flight Center's Materials and Processes Laboratory supports many Programs/ Projects that design, manufacture, and test a wide range of hardware types that are sensitive to contamination and foreign object damage (FOD). Examples where contamination/FOD concerns arise include sensitive structural bondline failure, critical orifice blockage, seal leakage, and reactive fluid compatibility (liquid oxygen, hydrazine) as well as performance degradation of sensitive instruments or spacecraft surfaces such as optical elements and thermal control systems. During the design phase, determination of the sensitivity of a hardware system to different types or levels of contamination/FOD is essential. A contamination control and FOD control plan must then be developed and implemented through all phases of ground processing, and, sometimes, on-orbit use, recovery, and refurbishment. Implementation of proper controls prevents cost and schedule impacts due to hardware damage or rework and helps assure mission success. Current capabilities are being used to support recent and on-going activities for multiple Mission Directorates / Programs such as International Space Station (ISS), James Webb Space Telescope (JWST), Space Launch System (SLS) elements (tanks, engines, booster), etc. The team also advances Green Technology initiatives and addresses materials obsolescence issues for NASA and external customers, most notably in the area of solvent replacement (e.g. aqueous cleaners containing hexavalent chrome, ozone depleting chemicals (CFC s and HCFC's), suspect carcinogens). The team evaluates new surface cleanliness inspection and cleaning technologies (e.g. plasma cleaning), and maintains databases for processing support materials as well as outgassing and optical compatibility test results for spaceflight environments.

  13. A Stitch in Time: Strategic Self-Control in High School and College Students.

    PubMed

    Duckworth, Angela L; White, Rachel E; Matteucci, Alyssa J; Shearer, Annie; Gross, James J

    2016-04-01

    A growing body of research indicates that self-control is critical to academic success. Surprisingly little is known, however, about the diverse strategies students use to implement self-control or how well these strategies work. To address these issues, we conducted a naturalistic investigation of self-control strategies (Study 1) and two field experiments (Studies 2 and 3). In Study 1, high school students described the strategies they use to manage interpersonal conflicts, get academic work done, eat healthfully, and manage other everyday self-control challenges. The majority of strategies in these self-nominated incidents as well as in three hypothetical academic scenarios (e.g., studying instead of texting friends) were reliably classified using the process model of self-control. As predicted by the process model, students rated strategies deployed early in the impulse-generation process (situation selection, situation modification) as being dramatically more effective than strategies deployed later (attentional deployment, cognitive change, response modulation). In Study 2, high school students randomly assigned to implement situation modification were more likely to meet their academic goals during the following week than students assigned either to implement response modulation or no strategy at all. In Study 3, college students randomly assigned to implement situation modification were also more successful in meeting their academic goals, and this effect was partially mediated by decreased feelings of temptation throughout the week. Collectively, these findings suggest that students might benefit from learning to initiate self-control when their impulses are still nascent.

  14. A Stitch in Time: Strategic Self-Control in High School and College Students

    PubMed Central

    Duckworth, Angela L.; White, Rachel E.; Matteucci, Alyssa J.; Shearer, Annie; Gross, James J.

    2015-01-01

    A growing body of research indicates that self-control is critical to academic success. Surprisingly little is known, however, about the diverse strategies students use to implement self-control or how well these strategies work. To address these issues, we conducted a naturalistic investigation of self-control strategies (Study 1) and two field experiments (Studies 2 and 3). In Study 1, high school students described the strategies they use to manage interpersonal conflicts, get academic work done, eat healthfully, and manage other everyday self-control challenges. The majority of strategies in these self-nominated incidents as well as in three hypothetical academic scenarios (e.g., studying instead of texting friends) were reliably classified using the process model of self-control. As predicted by the process model, students rated strategies deployed early in the impulse-generation process (situation selection, situation modification) as being dramatically more effective than strategies deployed later (attentional deployment, cognitive change, response modulation). In Study 2, high school students randomly assigned to implement situation modification were more likely to meet their academic goals during the following week than students assigned either to implement response modulation or no strategy at all. In Study 3, college students randomly assigned to implement situation modification were also more successful in meeting their academic goals, and this effect was partially mediated by decreased feelings of temptation throughout the week. Collectively, these findings suggest that students might benefit from learning to initiate self-control when their impulses are still nascent. PMID:27158155

  15. Top-down causation by information control: from a philosophical problem to a scientific research programme

    PubMed Central

    Auletta, G; Ellis, G.F.R; Jaeger, L

    2008-01-01

    It has been claimed that different types of causes must be considered in biological systems, including top-down as well as same-level and bottom-up causation, thus enabling the top levels to be causally efficacious in their own right. To clarify this issue, the important distinctions between information and signs are introduced here and the concepts of information control and functional equivalence classes in those systems are rigorously defined and used to characterize when top-down causation by feedback control happens, in a way that is testable. The causally significant elements we consider are equivalence classes of lower level processes, realized in biological systems through different operations having the same outcome within the context of information control and networks. PMID:18319208

  16. ISO learning approximates a solution to the inverse-controller problem in an unsupervised behavioral paradigm.

    PubMed

    Porr, Bernd; von Ferber, Christian; Wörgötter, Florentin

    2003-04-01

    In "Isotropic Sequence Order Learning" (pp. 831-864 in this issue), we introduced a novel algorithm for temporal sequence learning (ISO learning). Here, we embed this algorithm into a formal nonevaluating (teacher free) environment, which establishes a sensor-motor feedback. The system is initially guided by a fixed reflex reaction, which has the objective disadvantage that it can react only after a disturbance has occurred. ISO learning eliminates this disadvantage by replacing the reflex-loop reactions with earlier anticipatory actions. In this article, we analytically demonstrate that this process can be understood in terms of control theory, showing that the system learns the inverse controller of its own reflex. Thereby, this system is able to learn a simple form of feedforward motor control.

  17. Critical Issues in Crime Control Policy.

    ERIC Educational Resources Information Center

    Flynn, Edith Elisabeth, Ed.

    1983-01-01

    Entire issue discusses crime control policy in the United States, including such issues as the relation of social and environmental variables to criminal activity, dealing with the career offender, biological correlates of criminal behavior, juvenile delinquency, and white collar crime. (CS)

  18. [Challenges to implementation of the ECG reading center in ELSA-Brasil].

    PubMed

    Ribeiro, Antonio Luiz; Pereira, Samuel Vianney da Cunha; Bergmann, Kaiser; Ladeira, Roberto Marini; Oliveira, Rackel Aguiar Mendes; Lotufo, Paulo A; Mill, José Geraldo; Barreto, Sandhi Maria

    2013-06-01

    Electrocardiography is an established low-cost method of cardiovascular assessment, utilized for decades large epidemiological studies. Nonetheless, its use in large epidemiological studies presents challenges, especially when seeking to develop a reading center. This article describes the process, difficulties and challenges of implementing an electrocardiogram reading center in Brazilian Longitudinal Study for Adult Health (ELSA-Brasil). Among the issues discussed, we have emphasized: the criteria for selection of the electrocardiography machine and the central for storage and management of the machines; the required personnel; the procedures for acquisition and transmission of electrocardiographs to the Reading Center; coding systems, with emphasis on the Minnesota code; ethical and practical issues regarding the delivery of reports to study participants; and aspects related to quality control.

  19. Introduction to "northern Gulf of Mexico ecosystem change and hazards susceptibility"

    USGS Publications Warehouse

    Brock, J.C.; Lavoie, D.L.; Poore, R.Z.

    2009-01-01

    The northern Gulf of Mexico and its diverse natural resources are threatened by population and development pressure, and by the impacts of rising sea level and severe storms. In the wake of the devastating 2005 hurricane season, and in response to the complex management issues facing the region, the U.S. Geological Survey organized the multidisciplinary "Northern Gulf of Mexico Ecosystem Change and Hazards Susceptibility" project. This special issue of Geo-Marine Letters hosts a few of the early results in the form of 11 papers covering three themes: (1) the control exerted by the underlying geologic framework on geomorphology and nearshore processes and features; (2) impact of human activities on nearshore water quality; and (3) hurricanes and associated effects. ?? 2009 US Government.

  20. Eutrophication of lakes and reservoirs: A framework for making management decisions

    USGS Publications Warehouse

    Rast, W.; Holland, M.

    1988-01-01

    The development of management strategies for the protection of environmental quality usually involves consideration both of technical and nontechnical issues. A logical, step-by-step framework for development of such strategies is provided. Its application to the control of cultured eutrophication of lakes and reservoirs illustrates its potential usefulness. From the perspective of the policymaker, the main consideration is that the eutrophication-related water quality of a lake or reservoir can be managed for given water uses. The approach presented here allows the rational assessment of relevant water-quality parameters and establishment of water-quality goals, consideration of social and other nontechnical issues, the possibilities of public involvement in the decision-making process, and a reasonable economic analysis within a management framework.

  1. Important issues in the justification of a control treatment in paediatric drug trials.

    PubMed

    Kelly, Lauren E; Davies, Elin Haf; Saint-Raymond, Agnes; Tomasi, Paolo; Offringa, Martin

    2016-10-01

    The value of comparative effectiveness trials in informing clinical and policy decisions depends heavily on the choice of control arm (comparator). Our objective is to identify challenges in comparator reasoning and to determine justification criteria for selecting a control arm in paediatric clinical trials. A literature search was completed to identify existing sources of guidance on comparator selection. Subsequently, we reviewed a randomly selected sample of comparators selected for paediatric investigation plans (PIPs) adopted by the Paediatric Committee of the European Medicines Agency in 2013. We gathered descriptive information and evaluated their review process to identify challenges and compromises between regulators and sponsors with regard to the selection of the comparator. A tool to help investigators justify the selection of active controls and placebo arms was developed using the existing literature and empirical data. Justifying comparator selection was a challenge in 28% of PIPs. The following challenging paediatric issues in the decision-making process were identified: use of off-label medications as comparators, ethical and safe use of placebo, duration of placebo use, an undefined optimal dosing strategy, lack of age-appropriate safety and efficacy data, and drug dosing not supported by extrapolation of safety/efficacy evidence from other populations. In order to generate trials that will inform clinical decision-making and support marketing authorisations, researchers must systemically and transparently justify their selection of the comparator arm for their study. This report highlights key areas for justification in the choice of comparator in paediatric clinical trials. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  2. Can we save large carnivores without losing large carnivore science?

    USGS Publications Warehouse

    Allen, Benjamin L.; Allen, Lee R.; Andrén, Henrik; Ballard, Guy; Boitani, Luigi; Engeman, Richard M.; Fleming, Peter J.S.; Haswell, Peter M.; Ford, Adam T.; Kowalczyk, Rafał; Mech, L. David; Linnell, John D.C.; Parker, Daniel M.

    2017-01-01

    Large carnivores are depicted to shape entire ecosystems through top-down processes. Studies describing these processes are often used to support interventionist wildlife management practices, including carnivore reintroduction or lethal control programs. Unfortunately, there is an increasing tendency to ignore, disregard or devalue fundamental principles of the scientific method when communicating the reliability of current evidence for the ecological roles that large carnivores may play, eroding public confidence in large carnivore science and scientists. Here, we discuss six interrelated issues that currently undermine the reliability of the available literature on the ecological roles of large carnivores: (1) the overall paucity of available data, (2) reliability of carnivore population sampling techniques, (3) general disregard for alternative hypotheses to top-down forcing, (4) lack of applied science studies, (5) frequent use of logical fallacies, and (6) generalisation of results from relatively pristine systems to those substantially altered by humans. We first describe how widespread these issues are, and given this, show, for example, that evidence for the roles of wolves (Canis lupus) and dingoes (Canis lupus dingo) in initiating trophic cascades is not as strong as is often claimed. Managers and policy makers should exercise caution when relying on this literature to inform wildlife management decisions. We emphasise the value of manipulative experiments and discuss the role of scientific knowledge in the decision-making process. We hope that the issues we raise here prompt deeper consideration of actual evidence, leading towards an improvement in both the rigour and communication of large carnivore science.

  3. The REFLECT statement: methods and processes of creating reporting guidelines for randomized controlled trials for livestock and food safety.

    PubMed

    O'Connor, A M; Sargeant, J M; Gardner, I A; Dickson, J S; Torrence, M E; Dewey, C E; Dohoo, I R; Evans, R B; Gray, J T; Greiner, M; Keefe, G; Lefebvre, S L; Morley, P S; Ramirez, A; Sischo, W; Smith, D R; Snedeker, K; Sofos, J; Ward, M P; Wills, R

    2010-01-01

    The conduct of randomized controlled trials in livestock with production, health, and food-safety outcomes presents unique challenges that might not be adequately reported in trial reports. The objective of this project was to modify the CONSORT (Consolidated Standards of Reporting Trials) statement to reflect the unique aspects of reporting these livestock trials. A 2-day consensus meeting was held on November 18-19, 2008 in Chicago, IL, to achieve the objective. Before the meeting, a Web-based survey was conducted to identify issues for discussion. The 24 attendees were biostatisticians, epidemiologists, food-safety researchers, livestock production specialists, journal editors, assistant editors, and associate editors. Before the meeting, the attendees completed a Web-based survey indicating which CONSORT statement items would need to be modified to address unique issues for livestock trials. The consensus meeting resulted in the production of the REFLECT (Reporting Guidelines for Randomized Control Trials) statement for livestock and food safety and 22-item checklist. Fourteen items were modified from the CONSORT checklist, and an additional subitem was proposed to address challenge trials. The REFLECT statement proposes new terminology, more consistent with common usage in livestock production, to describe study subjects. Evidence was not always available to support modification to or inclusion of an item. The use of the REFLECT statement, which addresses issues unique to livestock trials, should improve the quality of reporting and design for trials reporting production, health, and food-safety outcomes.

  4. Independent Orbiter Assessment (IOA): FMEA/CIL assessment

    NASA Technical Reports Server (NTRS)

    Hinsdale, L. W.; Swain, L. J.; Barnes, J. E.

    1988-01-01

    The McDonnell Douglas Astronautics Company (MDAC) was selected to perform an Independent Orbiter Assessment (IOA) of the Failure Modes and Effects Analysis (FMEA) and Critical Items List (CIL). Direction was given by the Orbiter and GFE Projects Office to perform the hardware analysis and assessment using the instructions and ground rules defined in NSTS 22206. The IOA analysis featured a top-down approach to determine hardware failure modes, criticality, and potential critical items. To preserve independence, the analysis was accomplished without reliance upon the results contained within the NASA and Prime Contractor FMEA/CIL documentation. The assessment process compared the independently derived failure modes and criticality assignments to the proposed NASA post 51-L FMEA/CIL documentation. When possible, assessment issues were discussed and resolved with the NASA subsystem managers. Unresolved issues were elevated to the Orbiter and GFE Projects Office manager, Configuration Control Board (CCB), or Program Requirements Control Board (PRCB) for further resolution. The most important Orbiter assessment finding was the previously unknown stuck autopilot push-button criticality 1/1 failure mode. The worst case effect could cause loss of crew/vehicle when the microwave landing system is not active. It is concluded that NASA and Prime Contractor Post 51-L FMEA/CIL documentation assessed by IOA is believed to be technically accurate and complete. All CIL issues were resolved. No FMEA issues remain that have safety implications. Consideration should be given, however, to upgrading NSTS 22206 with definitive ground rules which more clearly spell out the limits of redundancy.

  5. Covert effects of "one drink" of alcohol on brain processes related to car driving: an event-related potential study.

    PubMed

    Ebe, Kazutoshi; Itoh, Kosuke; Kwee, Ingrid L; Nakada, Tsutomu

    2015-04-23

    The effects of a low dose of alcohol on car driving remain controversial. To address this issue, event-related potentials were recorded while subjects performed a simple car-following task in a driving simulator before and after consuming either "one drink" of beer (representing one standard alcoholic beverage containing 14 g of alcohol) or mineral water (control condition). Subjects who had consumed the determined amount of alcohol demonstrated no detectable outward behavioral signs of intoxication while performing the driving task, an observation in agreement with previous findings. However, the parietal P3 elicited by the brake lights of the preceding car was significantly reduced in amplitude, approximately 50% that observed under the control condition, likely indicating alteration of the neural processing of visual information critical for safe driving. The finding suggests that alcohol begins to affect neural processes for driving even at quantities too low to modify behavior. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  6. State and Local Perspective on Implementation of the Centers for Disease Control and Prevention Dog Confinement Agreement.

    PubMed

    Zaganjor, I; Sinclair, J R; Coleman, M S

    2015-12-01

    The Centers for Disease Control and Prevention (CDC) works in conjunction with state, territorial, local and tribal agencies (STLTAs) to prevent the transmission of infectious agents. Issuance of confinement agreements using CDC Form 75.37 'Notice to Owners and Importers of Dogs' to importers of dogs that are not vaccinated or incompletely vaccinated against rabies is part of the agency's regulatory programme to prevent the entry of dogs infected with rabies. Although this is a regulatory programme that depends heavily on partnerships between CDC and STLTAs, CDC had never formally evaluated the acceptability of the confinement agreement process with these partners. Thus, a short survey of nine STLTAs was conducted to evaluate whether these partners have enough personnel and resources to implement the regulation and their general opinions of the confinement agreement process. The results illustrate that CDC partners are dissatisfied to some extent with the process, and there are multiple issues limiting their success in enforcing the regulation. © 2015 Blackwell Verlag GmbH.

  7. Retrieval-practice task affects relationship between working memory capacity and retrieval-induced forgetting.

    PubMed

    Storm, Benjamin C; Bui, Dung C

    2016-11-01

    Retrieving a subset of items from memory can cause forgetting of other items in memory, a phenomenon referred to as retrieval-induced forgetting (RIF). Individuals who exhibit greater amounts of RIF have been shown to also exhibit superior working memory capacity (WMC) and faster stop-signal reaction times (SSRTs), results which have been interpreted as suggesting that RIF reflects an inhibitory process that is mediated by the processes of executive control. Across four experiments, we sought to further elucidate this issue by manipulating the way in which participants retrieved items during retrieval practice and examining how the resulting effects of forgetting correlated with WMC (Experiments 1-3) and SSRT (Experiment 4). Significant correlations were observed when participants retrieved items from an earlier study phase (within-list retrieval practice), but not when participants generated items from semantic memory (extra-list retrieval practice). These results provide important new insight into the role of executive-control processes in RIF.

  8. State of the Art Control Measures for Aluminium Fade and SEN Clogging during Steelmaking Operations

    NASA Astrophysics Data System (ADS)

    Kamaraj, Ashok; Saravanakumar, R.; Rajaguru, M.

    2018-02-01

    Crack formation, fatigue failure of components and other process interruptions in liquid steel practices such as ladle nozzle clogging, SEN clogging, break outs are mainly due to residual deoxidation products such as alumina present in steels. The present paper deals with the issues in steel processing operations and provides state-of-the-art control measures for clean steel production. Investigations regarding the residual alumina content and its consequences at integrated steel plant shows that, Al-fade of maximum 0.02% is observed, which produces equivalent of 37 Kg of alumina in the liquid steel. Furthermore, slag carry over, re-oxidation, improper argon rinsing practice, aluminium consumption at secondary steelmaking practices also influences the alumina formation during steelmaking practices. The residual alumina not only affects the quality of steel, but also results in process interruptions such as ladle choking, SEN choking, subsequent break outs etc. various steelmaking practices influences clogging and aluminium fade are discussed and possible suggestions are given to improve the cleanliness of steel.

  9. Cryogenic fluid management in space

    NASA Technical Reports Server (NTRS)

    Antar, Basil N.

    1988-01-01

    Many future space based vehicles and satellites will require on orbit refuelling procedures. Cryogenic fluid management technology is being developed to assess the requirements of such procedures as well as to aid in the design and development of these vehicles. Cryogenic fluid management technology for this application could be divided into two areas of study, one is concerned with fluid transfer process and the other with cryogenic liquid storage. This division is based upon the needed technology for the development of each area. In the first, the interaction of fluid dynamics with thermodynamics is essential, while in the second only thermodynamic analyses are sufficient to define the problem. The following specific process related to the liquid transfer area are discussed: tank chilldown and fill; tank pressurization; liquid positioning; and slosh dynamics and control. These specific issues are discussed in relation with the required technology for their development in the low gravity application area. In each process the relevant physics controlling the technology is identified and methods for resolving some of the basic questions are discussed.

  10. Export Control Requirements for Tritium Processing Design and R&D

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hollis, William Kirk; Maynard, Sarah-Jane Wadsworth

    This document will address requirements of export control associated with tritium plant design and processes. Los Alamos National Laboratory has been working in the area of tritium plant system design and research and development (R&D) since the early 1970’s at the Tritium Systems Test Assembly (TSTA). This work has continued to the current date with projects associated with the ITER project and other Office of Science Fusion Energy Science (OS-FES) funded programs. ITER is currently the highest funding area for the DOE OS-FES. Although export control issues have been integrated into these projects in the past a general guidance documentmore » has not been available for reference in this area. To address concerns with currently funded tritium plant programs and assist future projects for FES, this document will identify the key reference documents and specific sections within related to tritium research. Guidance as to the application of these sections will be discussed with specific detail to publications and work with foreign nationals.« less

  11. Modeling Negotiation by a Paticipatory Approach

    NASA Astrophysics Data System (ADS)

    Torii, Daisuke; Ishida, Toru; Bousquet, François

    In a participatory approach by social scientists, role playing games (RPG) are effectively used to understand real thinking and behavior of stakeholders, but RPG is not sufficient to handle a dynamic process like negotiation. In this study, a participatory simulation where user-controlled avatars and autonomous agents coexist is introduced to the participatory approach for modeling negotiation. To establish a modeling methodology of negotiation, we have tackled the following two issues. First, for enabling domain experts to concentrate interaction design for participatory simulation, we have adopted the architecture in which an interaction layer controls agents and have defined three types of interaction descriptions (interaction protocol, interaction scenario and avatar control scenario) to be described. Second, for enabling domain experts and stakeholders to capitalize on participatory simulation, we have established a four-step process for acquiring negotiation model: 1) surveys and interviews to stakeholders, 2) RPG, 3) interaction design, and 4) participatory simulation. Finally, we discussed our methodology through a case study of agricultural economics in the northeast Thailand.

  12. Export Control Requirements for Tritium Processing Design and R&D

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hollis, William Kirk; Maynard, Sarah-Jane Wadsworth

    2015-10-30

    This document will address requirements of export control associated with tritium plant design and processes. Los Alamos National Laboratory has been working in the area of tritium plant system design and research and development (R&D) since the early 1970’s at the Tritium Systems Test Assembly (TSTA). This work has continued to the current date with projects associated with the ITER project and other Office of Science Fusion Energy Science (OS-FES) funded programs. ITER is currently the highest funding area for the DOE OS-FES. Although export control issues have been integrated into these projects in the past a general guidance documentmore » has not been available for reference in this area. To address concerns with currently funded tritium plant programs and assist future projects for FES, this document will identify the key reference documents and specific sections within related to tritium research. Guidance as to the application of these sections will be discussed with specific detail to publications and work with foreign nationals.« less

  13. Use of Portal Monitors for Detection of Technogenic Radioactive Sources in Scrap Metal

    NASA Astrophysics Data System (ADS)

    Solovev, D. B.; Merkusheva, A. E.

    2017-11-01

    The article considers the features of organization of scrap-metal primary radiation control on the specialized enterprises engaging in its deep processing and storage at using by primary technical equipment - radiation portal monitors. The issue of this direction relevance, validity of radiation control implementation with the use of radiation portal monitors, physical and organizational bases of radiation control are considered in detail. The emphasis is put on the considerable increase in the number of technogenic radioactive sources detected in scrap-metal that results in the entering into exploitation of radioactive metallic structures as different building wares. One of reasons of such increase of the number of technogenic radioactive sources getting for processing with scrap-metal is the absence of any recommendations on the radiation portal monitors exploitation. The practical division of the article offers to recommendation on tuning of the modes of work of radiation portal monitors depending on influence the weather factor thus allowing to considerably increase the percent of technogenic radioactive sources detection.

  14. Manufacture of poly(methyl methacrylate) microspheres using membrane emulsification

    PubMed Central

    Bux, Jaiyana; Manga, Mohamed S.; Hunter, Timothy N.

    2016-01-01

    Accurate control of particle size at relatively narrow polydispersity remains a key challenge in the production of synthetic polymer particles at scale. A cross-flow membrane emulsification (XME) technique was used here in the preparation of poly(methyl methacrylate) microspheres at a 1–10 l h−1 scale, to demonstrate its application for such a manufacturing challenge. XME technology has previously been shown to provide good control over emulsion droplet sizes with careful choice of the operating conditions. We demonstrate here that, for an appropriate formulation, equivalent control can be gained for a precursor emulsion in a batch suspension polymerization process. We report here the influence of key parameters on the emulsification process; we also demonstrate the close correlation in size between the precursor emulsion and the final polymer particles. Two types of polymer particle were produced in this work: a solid microsphere and an oil-filled matrix microcapsule. This article is part of the themed issue ‘Soft interfacial materials: from fundamentals to formulation’. PMID:27298430

  15. Fall prevention modulates decisional saccadic behavior in aging.

    PubMed

    Coubard, Olivier A

    2012-01-01

    As society ages and frequency of falls increases in older adults, counteracting motor decline is a challenging issue for developed countries. Physical activity based on aerobic and strength training as well as motor activity based on skill learning both help benefit balance and reduce the risk of falls, as assessed by clinical or laboratory measures. However, how such programs influence motor control is a neglected issue. This study examined the effects of fall prevention (FP) training on saccadic control in older adults. Saccades were recorded in 12 participants aged 64-91 years before and after 2.5 months training in FP. Traditional analysis of saccade timing and dynamics was performed together with a quantitative analysis using the LATER model, enabling us to examine the underlying motor control processes. Results indicated that FP reduced the rate of anticipatory and express saccades in inappropriate directions and enhanced that of express saccades in the appropriate direction, resulting in decreased latency and higher left-right symmetry of motor responses. FP reduced within-participant variability of saccade duration, amplitude, and peak velocity. LATER analysis suggested that FP modulates decisional thresholds, extending our knowledge of motor training influence on central motor control. We introduce the Threshold Interval Modulation with Early Release-Rate of rIse Deviation with Early Release (TIMER-RIDER) model to account for the results.

  16. Software Certification - Coding, Code, and Coders

    NASA Technical Reports Server (NTRS)

    Havelund, Klaus; Holzmann, Gerard J.

    2011-01-01

    We describe a certification approach for software development that has been adopted at our organization. JPL develops robotic spacecraft for the exploration of the solar system. The flight software that controls these spacecraft is considered to be mission critical. We argue that the goal of a software certification process cannot be the development of "perfect" software, i.e., software that can be formally proven to be correct under all imaginable and unimaginable circumstances. More realistically, the goal is to guarantee a software development process that is conducted by knowledgeable engineers, who follow generally accepted procedures to control known risks, while meeting agreed upon standards of workmanship. We target three specific issues that must be addressed in such a certification procedure: the coding process, the code that is developed, and the skills of the coders. The coding process is driven by standards (e.g., a coding standard) and tools. The code is mechanically checked against the standard with the help of state-of-the-art static source code analyzers. The coders, finally, are certified in on-site training courses that include formal exams.

  17. Processing of intended and unintended strategic issues and integration into the strategic agenda.

    PubMed

    Ridder, Hans-Gerd; Schrader, Jan Simon

    2017-11-01

    Strategic change is needed in hospitals due to external and internal pressures. However, research on strategic change, as a combination of management and medical expertise in hospitals, remains scarce. We analyze how intended strategic issues are processed into deliberate strategies and how unintended strategic issues are processed into emergent strategies in the management of strategy formation in hospitals. This study empirically investigates the integration of medical and management expertise in strategy formation. The longitudinal character of the case study enabled us to track patterns of intended and unintended strategic issues over 2 years. We triangulated data from interviews, observations, and documents. In accordance with the quality standards of qualitative research procedures, we analyzed the data by pattern matching and provided analytical generalization regarding strategy formation in hospitals. Our findings suggest that strategic issues are particularly successful within the strategy formation process if interest groups are concerned with the strategic issue, prospective profits are estimated, and relevant decisions makers are involved early on. Structure and interaction processes require clear criteria and transparent procedures for effective strategy formation. There is systematic neglect of medical expertise in processes of generating strategies. Our study reveals that the decentralized structure of medical centers is an adequate template for both the operationalization of intended strategic issues and the development of unintended strategic issues. However, tasks, roles, responsibility, resources, and administrative support are necessary for effective management of strategy formation. Similarly, criteria, procedures, and decision-making are prerequisites for effective strategy formation.

  18. High-speed civil transport flight- and propulsion-control technological issues

    NASA Technical Reports Server (NTRS)

    Ray, J. K.; Carlin, C. M.; Lambregts, A. A.

    1992-01-01

    Technology advances required in the flight and propulsion control system disciplines to develop a high speed civil transport (HSCT) are identified. The mission and requirements of the transport and major flight and propulsion control technology issues are discussed. Each issue is ranked and, for each issue, a plan for technology readiness is given. Certain features are unique and dominate control system design. These features include the high temperature environment, large flexible aircraft, control-configured empennage, minimizing control margins, and high availability and excellent maintainability. The failure to resolve most high-priority issues can prevent the transport from achieving its goals. The flow-time for hardware may require stimulus, since market forces may be insufficient to ensure timely production. Flight and propulsion control technology will contribute to takeoff gross weight reduction. Similar technology advances are necessary also to ensure flight safety for the transport. The certification basis of the HSCT must be negotiated between airplane manufacturers and government regulators. Efficient, quality design of the transport will require an integrated set of design tools that support the entire engineering design team.

  19. Operational efficiency subpanel advanced mission control

    NASA Technical Reports Server (NTRS)

    Friedland, Peter

    1990-01-01

    Herein, the term mission control will be taken quite broadly to include both ground and space based operations as well as the information infrastructure necessary to support such operations. Three major technology areas related to advanced mission control are examined: (1) Intelligent Assistance for Ground-Based Mission Controllers and Space-Based Crews; (2) Autonomous Onboard Monitoring, Control and Fault Detection Isolation and Reconfiguration; and (3) Dynamic Corporate Memory Acquired, Maintained, and Utilized During the Entire Vehicle Life Cycle. The current state of the art space operations are surveyed both within NASA and externally for each of the three technology areas and major objectives are discussed from a user point of view for technology development. Ongoing NASA and other governmental programs are described. An analysis of major research issues and current holes in the program are provided. Several recommendations are presented for enhancing the technology development and insertion process to create advanced mission control environments.

  20. AHPCRC (Army High Performance Computing Research Center) Bulletin. Volume 2, Issue 1

    DTIC Science & Technology

    2010-01-01

    Researchers in AHPCRC Technical Area 4 focus on improving processes for developing scalable, accurate parallel programs that are easily ported from one...control number. 1. REPORT DATE 2011 2. REPORT TYPE 3. DATES COVERED 00-00-2011 to 00-00-2011 4 . TITLE AND SUBTITLE AHPCRC (Army High...continued on page 4 Virtual levels in Sequoia represent an abstract memory hierarchy without specifying data transfer mechanisms, giving the

  1. Aerospace Non Chrome Corrosion Inhibiting Primer Systems

    DTIC Science & Technology

    2009-09-01

    Meet all HSE specifications, TSCA, REACh, Akzo • Strippable • No weight increase over current system • Meet specification requirements for corrosion, not...Positive and negative controls • Primer only and topcoated samples Aerospace Coatings | Title 9 OEM CF Optimization/ Down Selects •Usual issues...found to be true • Good NSS ≠ Good filiform ≠ Good cure ≠ Good application properties • Down select process is to minimize ≠ and move to a balance of

  2. Mathematics and Physics Studies - Multi-Project Support

    DTIC Science & Technology

    1989-09-02

    measurements). A quaternion form is used to represent any finite rotation of a rigid body as a rotation through some angle about a fixed axis (Euler’s...many - contractual issues. Drs. Edmond Murad (GL/PHK) and Roger Van Tassel (GL/OPB) provided important suggestions and feedback on the data processing...Orbital Maneuvering System (OMS) and the Reaction Control System (RCS) resemble plumes produced by targets/events of interest. Measurements from the IBSS

  3. Effects of hypoxia on sympathetic neural control in humans

    NASA Technical Reports Server (NTRS)

    Smith, M. L.; Muenter, N. K.

    2000-01-01

    This special issue is principally focused on the time domain of the adaptive mechanisms of ventilatory responses to short-term, long-term and intermittent hypoxia. The purpose of this review is to summarize the limited literature on the sympathetic neural responses to sustained or intermittent hypoxia in humans and attempt to discern the time domain of these responses and potential adaptive processes that are evoked during short and long-term exposures to hypoxia.

  4. Data quality control in eco-environmental monitoring

    NASA Astrophysics Data System (ADS)

    Lu, Chunyan; Wang, Jing

    2007-11-01

    With the development of science and technology, a number of environmental issues, such as sustainable development, climate change, environmental pollution, and land degradation become serious. Greater attention has been attached to environmental protection. The government gradually launched some eco--environmental construction projects. In 1999, China begin to carry out the project of Grain-for-Green in the west, to improve the eco-environment, and it make some good effect, but there are some questions that still can not be answered. How about the new grass or forest? Where are they? How can we do in the future? To answer these questions, the government began to monitor the eco-environment, based on remote sensing technology. Geography information can be attained timely, but the issue of uncertainty has become increasingly recognized, and this uncertainty affects the reliability of applications using the data. This article analyzed the process of eco-environment monitoring, the uncertainty of geography information, and discussed the methods of data quality control. The Spot5 span data and multi-spectral data in 2003(2002) were used, combined with land use survey data at the scale of 1:10,000, topography data at the scale of 1:10,000, and the local Grain-for-Green project map. Also the social and economic data were collected. Eco-environmental monitoring is a process which consists of several steps, such as image geometric correction, image matching, information extraction, and so on. Based on visual and automated method, land information turned to grass and forest from cultivated land was obtained by comparing the information form remote sensing data with the land survey data, and local Grain-for-Green project data, combined with field survey. According to the process, the uncertainty in the process was analyzed. Positional uncertainty, attribute uncertainty, and thematic uncertainty was obvious. Positional uncertainty mainly derived from image geometric correction, such as data resource, the number and spatial distribution of the control points are important resource of uncertainty. Attribution uncertainty mainly derived from the process of information extraction. Land classification system, artificial error was the main factor induced uncertainty. Concept defined was not clear, and it reduced thematic uncertainty. According to the resource of uncertainty, data quality control methods were put forward to improve the data quality. At first, it is more important to choose appropriate remote sensing data and other basic data. Secondly, the accuracy of digital orthophoto map should be controlled. Thirdly, it is necessary to check the result data according to relative data quality criterion to guarantee GIS data quality.

  5. From atomistic interfaces to dendritic patterns

    NASA Astrophysics Data System (ADS)

    Galenko, P. K.; Alexandrov, D. V.

    2018-01-01

    Transport processes around phase interfaces, together with thermodynamic properties and kinetic phenomena, control the formation of dendritic patterns. Using the thermodynamic and kinetic data of phase interfaces obtained on the atomic scale, one can analyse the formation of a single dendrite and the growth of a dendritic ensemble. This is the result of recent progress in theoretical methods and computational algorithms calculated using powerful computer clusters. Great benefits can be attained from the development of micro-, meso- and macro-levels of analysis when investigating the dynamics of interfaces, interpreting experimental data and designing the macrostructure of samples. The review and research articles in this theme issue cover the spectrum of scales (from nano- to macro-length scales) in order to exhibit recently developing trends in the theoretical analysis and computational modelling of dendrite pattern formation. Atomistic modelling, the flow effect on interface dynamics, the transition from diffusion-limited to thermally controlled growth existing at a considerable driving force, two-phase (mushy) layer formation, the growth of eutectic dendrites, the formation of a secondary dendritic network due to coalescence, computational methods, including boundary integral and phase-field methods, and experimental tests for theoretical models-all these themes are highlighted in the present issue. This article is part of the theme issue `From atomistic interfaces to dendritic patterns'.

  6. Publisher's Announcement

    NASA Astrophysics Data System (ADS)

    McGlashan, Yasmin

    2008-01-01

    Important changes for 2008 As a result of reviewing several aspects of our content, both in print and online, we have made some changes for 2008. These changes are described below: Article numbering Plasma Physics and Controlled Fusion has moved from sequential page numbering to an article numbering system, offering important advantages and flexibility by speeding up the publication process. Papers in different issues or sections can be published online as soon as they are ready, without having to wait for a whole issue or section to be allocated page numbers. The bibliographic citation will change slightly. Articles should be referenced using the six-digit article number in place of a page number, and this number must include any leading zeros. For instance, from this issue: Z Y Chen et al 2008 Plasma Phys. Control. Fusion 50 015001 Articles will continue to be published on the web in advance of the print edition. A new look and feel We have also taken the opportunity to refresh the design of the journal cover, in order to modernise the typography and create a consistent look and feel across our range of publications. We hope you like the new cover. If you have any questions or comments about any of these changes, please contact us at ppcf@iop.org.

  7. Multi-team dynamics and distributed expertise in imission operations.

    PubMed

    Caldwell, Barrett S

    2005-06-01

    The evolution of space exploration has brought an increased awareness of the social and socio-technical issues associated with team performance and task coordination, both for the onboard astronauts and in mission control. Spaceflight operations create a unique environment in which to address classic group dynamics topics including communication, group process, knowledge development and sharing, and time-critical task performance. Mission operations in the early years of the 21st century have developed into a set of complex, multi-team task settings incorporating multiple mission control teams and flight crews interacting in novel ways. These more complex operational settings help highlight the emergence of a new paradigm of distributed supervisory coordination, and the need to consider multiple dimensions of expertise being supported and exchanged among team members. The creation of new mission profiles with very long-duration time scales (months, rather than days) for the International Space Station, as well as planned exploration missions to the Moon and Mars, emphasize fundamental distinctions from the 40 yr from Mercury to the Space Shuttle. Issues in distributed expertise and information flow in mission control settings from two related perspectives are described. A general conceptual view of knowledge sharing and task synchronization is presented within the context of the mission control environment. This conceptual presentation is supplemented by analysis of quasi-experimental data collected from actual flight controllers at NASA-Johnson Space Center, Houston, TX.

  8. Redox and Nitric Oxide-Mediated Regulation of Sensory Neuron Ion Channel Function

    PubMed Central

    2015-01-01

    Abstract Significance: Reactive oxygen and nitrogen species (ROS and RNS, respectively) can intimately control neuronal excitability and synaptic strength by regulating the function of many ion channels. In peripheral sensory neurons, such regulation contributes towards the control of somatosensory processing; therefore, understanding the mechanisms of such regulation is necessary for the development of new therapeutic strategies and for the treatment of sensory dysfunctions, such as chronic pain. Recent Advances: Tremendous progress in deciphering nitric oxide (NO) and ROS signaling in the nervous system has been made in recent decades. This includes the recognition of these molecules as important second messengers and the elucidation of their metabolic pathways and cellular targets. Mounting evidence suggests that these targets include many ion channels which can be directly or indirectly modulated by ROS and NO. However, the mechanisms specific to sensory neurons are still poorly understood. This review will therefore summarize recent findings that highlight the complex nature of the signaling pathways involved in redox/NO regulation of sensory neuron ion channels and excitability; references to redox mechanisms described in other neuron types will be made where necessary. Critical Issues: The complexity and interplay within the redox, NO, and other gasotransmitter modulation of protein function are still largely unresolved. Issues of specificity and intracellular localization of these signaling cascades will also be addressed. Future Directions: Since our understanding of ROS and RNS signaling in sensory neurons is limited, there is a multitude of future directions; one of the most important issues for further study is the establishment of the exact roles that these signaling pathways play in pain processing and the translation of this understanding into new therapeutics. Antioxid. Redox Signal. 22, 486–504. PMID:24735331

  9. Culpability and pain management/control in peripheral vascular disease using the ethics of principles and care.

    PubMed

    Omery, A

    1991-09-01

    The purposes of this article were to provide insight into the process of ethics and ethical inquiry and to explore the ethical issues of culpability and pain management/control. Critical care nurses who currently care for vascular patients identified these issues as occurring frequently in their practice. Authors in critical care nursing generally have limited the process of ethical inquiry to a theoretical framework built around an ethic of principles. The message many critical care nurses heard was that this one type of theoretical ethical framework was the totality of ethics. The application of these principles was ethical inquiry. For some nurses, the ethic of principles is sufficient. For others, an ethic of principles is either incomplete or foreign. This second group of nurses may believe that they have no moral voice if the language of ethics is only the language of principles. The language of principles, however, is not the only theoretical framework available. There is also the ethic of care, and ethical inquiry can include the application of that framework. Indeed, the language of the ethic of care may give a voice to nurses who previously felt morally mute. In fact, these two theoretical frameworks are not the only frameworks available to nurses. There is also virtue ethics, a framework not discussed in this article. A multiplicity of ethical frameworks is available for nurses to use in analyzing their professional and personal dilemmas. Recognizing that multiplicity, nurses can analyze their ethical dilemmas more comprehensively and effectively. Applying differing ethical frameworks can result in the same conclusions. This was the case for the issue of culpability.(ABSTRACT TRUNCATED AT 250 WORDS)

  10. Integrated Seismological Network of Brazil: Key developments in technology.

    NASA Astrophysics Data System (ADS)

    Pirchiner, Marlon; Assumpção, Marcelo; Ferreira, Joaquim; França, George

    2010-05-01

    The Integrated Seismological Network of Brazil - BRASIS - will integrate the main Brazilian seismology groups in an extensive permanent broadband network with a (near) real-time acquisition system and automatic preliminary processing of epicenters and magnitudes. About 60 stations will cover the whole country to continuously monitor the seismic activity. Most stations will be operating by the end of 2010. Data will be received from remote stations at each research group and redistributed to all other groups. In addition to issuing a national catalog of earthquakes, each institution will make its own analysis and issue their own bulletins taking into account local and regional lithospheric structure. We chose the SEED format, seedlink and SeisComP as standard data format, exchange protocol and software framework for the network management, respectively. All different existing equipment (eg, Guralp/Scream, Geotech/CD1.1, RefTek/RTP, Quanterra/seedlink) will be integrated into the same system. We plan to provide: 1) improved station management through remote control, and indexes for quality control of acquired data, sending alerts to operators in critical cases. 2) automatic processing: picking, location with local and regional models and determination of magnitudes, issuing newsletters and alerts. 3) maintainence of an earthquakes catalog, and a waveforms database. 4) query tools and access to metadata, catalogs and waveform available to all researchers. In addition, the catalog of earthquakes and other seismological data will be available as layers in a Spatial Data Infrastructure with open source standards, providing new analysis capabilities to all geoscientists. Seiscomp3 has already been installed in two centers (UFRN and USP) with successful tests of Q330, Guralp, RefTek and Geotech plug-ins to the seedlink protocol. We will discuss the main difficulties of our project and the solutions adopted to improve the Brazilian seismological infrastructure.

  11. Stability and sensitivity of ABR flow control protocols

    NASA Astrophysics Data System (ADS)

    Tsai, Wie K.; Kim, Yuseok; Chiussi, Fabio; Toh, Chai-Keong

    1998-10-01

    This tutorial paper surveys the important issues in stability and sensitivity analysis of ABR flow control of ATM networks. THe stability and sensitivity issues are formulated in a systematic framework. Four main cause of instability in ABR flow control are identified: unstable control laws, temporal variations of available bandwidth with delayed feedback control, misbehaving components, and interactions between higher layer protocols and ABR flow control. Popular rate-based ABR flow control protocols are evaluated. Stability and sensitivity is shown to be the fundamental issues when the network has dynamically-varying bandwidth. Simulation result confirming the theoretical studies are provided. Open research problems are discussed.

  12. Face processing in chronic alcoholism: a specific deficit for emotional features.

    PubMed

    Maurage, P; Campanella, S; Philippot, P; Martin, S; de Timary, P

    2008-04-01

    It is well established that chronic alcoholism is associated with a deficit in the decoding of emotional facial expression (EFE). Nevertheless, it is still unclear whether this deficit is specifically for emotions or due to a more general impairment in visual or facial processing. This study was designed to clarify this issue using multiple control tasks and the subtraction method. Eighteen patients suffering from chronic alcoholism and 18 matched healthy control subjects were asked to perform several tasks evaluating (1) Basic visuo-spatial and facial identity processing; (2) Simple reaction times; (3) Complex facial features identification (namely age, emotion, gender, and race). Accuracy and reaction times were recorded. Alcoholic patients had a preserved performance for visuo-spatial and facial identity processing, but their performance was impaired for visuo-motor abilities and for the detection of complex facial aspects. More importantly, the subtraction method showed that alcoholism is associated with a specific EFE decoding deficit, still present when visuo-motor slowing down is controlled for. These results offer a post hoc confirmation of earlier data showing an EFE decoding deficit in alcoholism by strongly suggesting a specificity of this deficit for emotions. This may have implications for clinical situations, where emotional impairments are frequently observed among alcoholic subjects.

  13. Experiments in Neural-Network Control of a Free-Flying Space Robot

    NASA Technical Reports Server (NTRS)

    Wilson, Edward

    1995-01-01

    Four important generic issues are identified and addressed in some depth in this thesis as part of the development of an adaptive neural network based control system for an experimental free flying space robot prototype. The first issue concerns the importance of true system level design of the control system. A new hybrid strategy is developed here, in depth, for the beneficial integration of neural networks into the total control system. A second important issue in neural network control concerns incorporating a priori knowledge into the neural network. In many applications, it is possible to get a reasonably accurate controller using conventional means. If this prior information is used purposefully to provide a starting point for the optimizing capabilities of the neural network, it can provide much faster initial learning. In a step towards addressing this issue, a new generic Fully Connected Architecture (FCA) is developed for use with backpropagation. A third issue is that neural networks are commonly trained using a gradient based optimization method such as backpropagation; but many real world systems have Discrete Valued Functions (DVFs) that do not permit gradient based optimization. One example is the on-off thrusters that are common on spacecraft. A new technique is developed here that now extends backpropagation learning for use with DVFs. The fourth issue is that the speed of adaptation is often a limiting factor in the implementation of a neural network control system. This issue has been strongly resolved in the research by drawing on the above new contributions.

  14. Multivariate statistical process control in product quality review assessment - A case study.

    PubMed

    Kharbach, M; Cherrah, Y; Vander Heyden, Y; Bouklouze, A

    2017-11-01

    According to the Food and Drug Administration and the European Good Manufacturing Practices (GMP) guidelines, Annual Product Review (APR) is a mandatory requirement in GMP. It consists of evaluating a large collection of qualitative or quantitative data in order to verify the consistency of an existing process. According to the Code of Federal Regulation Part 11 (21 CFR 211.180), all finished products should be reviewed annually for the quality standards to determine the need of any change in specification or manufacturing of drug products. Conventional Statistical Process Control (SPC) evaluates the pharmaceutical production process by examining only the effect of a single factor at the time using a Shewhart's chart. It neglects to take into account the interaction between the variables. In order to overcome this issue, Multivariate Statistical Process Control (MSPC) can be used. Our case study concerns an APR assessment, where 164 historical batches containing six active ingredients, manufactured in Morocco, were collected during one year. Each batch has been checked by assaying the six active ingredients by High Performance Liquid Chromatography according to European Pharmacopoeia monographs. The data matrix was evaluated both by SPC and MSPC. The SPC indicated that all batches are under control, while the MSPC, based on Principal Component Analysis (PCA), for the data being either autoscaled or robust scaled, showed four and seven batches, respectively, out of the Hotelling T 2 95% ellipse. Also, an improvement of the capability of the process is observed without the most extreme batches. The MSPC can be used for monitoring subtle changes in the manufacturing process during an APR assessment. Copyright © 2017 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

  15. Automatic assembly of micro-optical components

    NASA Astrophysics Data System (ADS)

    Gengenbach, Ulrich K.

    1996-12-01

    Automatic assembly becomes an important issue as hybrid micro systems enter industrial fabrication. Moving from a laboratory scale production with manual assembly and bonding processes to automatic assembly requires a thorough re- evaluation of the design, the characteristics of the individual components and of the processes involved. Parts supply for automatic operation, sensitive and intelligent grippers adapted to size, surface and material properties of the microcomponents gain importance when the superior sensory and handling skills of a human are to be replaced by a machine. This holds in particular for the automatic assembly of micro-optical components. The paper outlines these issues exemplified at the automatic assembly of a micro-optical duplexer consisting of a micro-optical bench fabricated by the LIGA technique, two spherical lenses, a wavelength filter and an optical fiber. Spherical lenses, wavelength filter and optical fiber are supplied by third party vendors, which raises the question of parts supply for automatic assembly. The bonding processes for these components include press fit and adhesive bonding. The prototype assembly system with all relevant components e.g. handling system, parts supply, grippers and control is described. Results of first automatic assembly tests are presented.

  16. Engineered decellularized matrices to instruct bone regeneration processes.

    PubMed

    Papadimitropoulos, Adam; Scotti, Celeste; Bourgine, Paul; Scherberich, Arnaud; Martin, Ivan

    2015-01-01

    Despite the significant progress in the field of bone tissue engineering, cell-based products have not yet reached the stage of clinical adoption. This is due to the uncertain advantages from the standard-of-care, combined with challenging cost-and regulatory-related issues. Novel therapeutic approaches could be based on exploitation of the intrinsic regenerative capacity of bone tissue, provided the development of a deeper understanding of its healing mechanisms. While it is well-established that endogenous progenitors can be activated toward bone formation by overdoses of single morphogens, the challenge to stimulate the healing processes by coordinated and controlled stimulation of specific cell populations remains open. Here, we review the recent approaches to generate osteoinductive materials based on the use of decellularized extracellular matrices (ECM) as reservoirs of multiple factors presented at physiological doses and through the appropriate ligands. We then propose the generation of customized engineered and decellularized ECM (i) as a tool to better understand the processes of bone regeneration and (ii) as safe and effective "off-the-shelf" bone grafts for clinical use. This article is part of a Special Issue entitled Stem Cells and Bone. Copyright © 2014 Elsevier Inc. All rights reserved.

  17. How individual traces and interactive timelines could support outage execution - Toward an outage historian concept

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Parfouru, S.; De-Beler, N.

    2012-07-01

    In the context of a project that is designing innovative ICT-based solutions for the organizational concept of outage management, we focus on the informational process of the OCR (Outage Control Room) underlying the execution of the outages. Informational process are based on structured and unstructured documents that have a key role in the collaborative processes and management of the outage. We especially track the structured and unstructured documents, electronically or not, from creation to sharing. Our analysis allows us to consider that the individual traces produced by an individual participant with a specific role could be multi-purpose and support sharingmore » between participants without creating duplication of work. The ultimate goal is to be able to generate an outage historian, that is not just focused on highly structured information, which could be useful to improve the continuity of information between participants. We study the implementation of this approach through web technologies and social media tools to address this issue. We also investigate the issue of data access through interactive visualization timelines coupled with other modality's to assist users in the navigation and exploration of the proposed historian. (authors)« less

  18. Hybrid overlay metrology for high order correction by using CDSEM

    NASA Astrophysics Data System (ADS)

    Leray, Philippe; Halder, Sandip; Lorusso, Gian; Baudemprez, Bart; Inoue, Osamu; Okagawa, Yutaka

    2016-03-01

    Overlay control has become one of the most critical issues for semiconductor manufacturing. Advanced lithographic scanners use high-order corrections or correction per exposure to reduce the residual overlay. It is not enough in traditional feedback of overlay measurement by using ADI wafer because overlay error depends on other process (etching process and film stress, etc.). It needs high accuracy overlay measurement by using AEI wafer. WIS (Wafer Induced Shift) is the main issue for optical overlay, IBO (Image Based Overlay) and DBO (Diffraction Based Overlay). We design dedicated SEM overlay targets for dual damascene process of N10 by i-ArF multi-patterning. The pattern is same as device-pattern locally. Optical overlay tools select segmented pattern to reduce the WIS. However segmentation has limit, especially the via-pattern, for keeping the sensitivity and accuracy. We evaluate difference between the viapattern and relaxed pitch gratings which are similar to optical overlay target at AEI. CDSEM can estimate asymmetry property of target from image of pattern edge. CDSEM can estimate asymmetry property of target from image of pattern edge. We will compare full map of SEM overlay to full map of optical overlay for high order correction ( correctables and residual fingerprints).

  19. Motor control may support mirror neuron research with new hypotheses and methods. Reply to comments on "Grasping synergies: A motor-control approach to the mirror neuron mechanism"

    NASA Astrophysics Data System (ADS)

    D'Ausilio, Alessandro; Bartoli, Eleonora; Maffongelli, Laura

    2015-03-01

    We are grateful to all commentators for their insightful commentaries and observations that enrich our proposal. One of our aims was indeed to bridge the gap between fields of research that, progressing independently, are facing similar issues regarding the neural representation of motor knowledge. In this respect, we were pleased to receive feedback from eminent researchers on both the mirror neuron as well as the motor control fields. Their expertise covers animal and human neurophysiology, as well as the computational modeling of neural and behavioral processes. Given their heterogeneous cultural perspectives and research approaches, a number of important open questions were raised. For simplicity we separated these issues into four sections. In the first section we present methodological aspects regarding how synergies can be measured in paradigms investigating the human mirror system. The second section regards the fundamental definition of what exactly synergies might be. The third concerns how synergies can generate testable predictions in mirror neuron research. Finally, the fourth section deals with the ultimate question regarding the function of the mirror neuron system.

  20. The 6th International Conference on Computer Science and Computational Mathematics (ICCSCM 2017)

    NASA Astrophysics Data System (ADS)

    2017-09-01

    The ICCSCM 2017 (The 6th International Conference on Computer Science and Computational Mathematics) has aimed to provide a platform to discuss computer science and mathematics related issues including Algebraic Geometry, Algebraic Topology, Approximation Theory, Calculus of Variations, Category Theory; Homological Algebra, Coding Theory, Combinatorics, Control Theory, Cryptology, Geometry, Difference and Functional Equations, Discrete Mathematics, Dynamical Systems and Ergodic Theory, Field Theory and Polynomials, Fluid Mechanics and Solid Mechanics, Fourier Analysis, Functional Analysis, Functions of a Complex Variable, Fuzzy Mathematics, Game Theory, General Algebraic Systems, Graph Theory, Group Theory and Generalizations, Image Processing, Signal Processing and Tomography, Information Fusion, Integral Equations, Lattices, Algebraic Structures, Linear and Multilinear Algebra; Matrix Theory, Mathematical Biology and Other Natural Sciences, Mathematical Economics and Financial Mathematics, Mathematical Physics, Measure Theory and Integration, Neutrosophic Mathematics, Number Theory, Numerical Analysis, Operations Research, Optimization, Operator Theory, Ordinary and Partial Differential Equations, Potential Theory, Real Functions, Rings and Algebras, Statistical Mechanics, Structure Of Matter, Topological Groups, Wavelets and Wavelet Transforms, 3G/4G Network Evolutions, Ad-Hoc, Mobile, Wireless Networks and Mobile Computing, Agent Computing & Multi-Agents Systems, All topics related Image/Signal Processing, Any topics related Computer Networks, Any topics related ISO SC-27 and SC- 17 standards, Any topics related PKI(Public Key Intrastructures), Artifial Intelligences(A.I.) & Pattern/Image Recognitions, Authentication/Authorization Issues, Biometric authentication and algorithms, CDMA/GSM Communication Protocols, Combinatorics, Graph Theory, and Analysis of Algorithms, Cryptography and Foundation of Computer Security, Data Base(D.B.) Management & Information Retrievals, Data Mining, Web Image Mining, & Applications, Defining Spectrum Rights and Open Spectrum Solutions, E-Comerce, Ubiquitous, RFID, Applications, Fingerprint/Hand/Biometrics Recognitions and Technologies, Foundations of High-performance Computing, IC-card Security, OTP, and Key Management Issues, IDS/Firewall, Anti-Spam mail, Anti-virus issues, Mobile Computing for E-Commerce, Network Security Applications, Neural Networks and Biomedical Simulations, Quality of Services and Communication Protocols, Quantum Computing, Coding, and Error Controls, Satellite and Optical Communication Systems, Theory of Parallel Processing and Distributed Computing, Virtual Visions, 3-D Object Retrievals, & Virtual Simulations, Wireless Access Security, etc. The success of ICCSCM 2017 is reflected in the received papers from authors around the world from several countries which allows a highly multinational and multicultural idea and experience exchange. The accepted papers of ICCSCM 2017 are published in this Book. Please check http://www.iccscm.com for further news. A conference such as ICCSCM 2017 can only become successful using a team effort, so herewith we want to thank the International Technical Committee and the Reviewers for their efforts in the review process as well as their valuable advices. We are thankful to all those who contributed to the success of ICCSCM 2017. The Secretary

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