The development and testing of the thermal break divertor monoblock target design delivering 20 MW m-2 heat load capability

NASA Astrophysics Data System (ADS)

Fursdon, M.; Barrett, T.; Domptail, F.; Evans, Ll M.; Luzginova, N.; Greuner, N. H.; You, J.-H.; Li, M.; Richou, M.; Gallay, F.; Visca, E.

2017-12-01

The design and development of a novel plasma facing component (for fusion power plants) is described. The component uses the existing ‘monoblock’ construction which consists of a tungsten ‘block’ joined via a copper interlayer to a through CuCrZr cooling pipe. In the new concept the interlayer stiffness and conductivity properties are tuned so that stress in the principal structural element of the component (the cooling pipe) is reduced. Following initial trials with off-the-shelf materials, the concept was realized by machined features in an otherwise solid copper interlayer. The shape and distribution of the features were tuned by finite element analyses subject to ITER structural design criterion in-vessel components (SDC-IC) design rules. Proof of concept mock-ups were manufactured using a two stage brazing process verified by tomography and micrographic inspection. Full assemblies were inspected using ultrasound and thermographic (SATIR) test methods at ENEA and CEA respectively. High heat flux tests using IPP’s GLADIS facility showed that 200 cycles at 20 MW m-2 and five cycles at 25 MW m-2 could be sustained without apparent component damage. Further testing and component development is planned.

The ENEA criticality accident dosimetry system: a contribution to the 2002 international intercomparison at the SILENE reactor.

PubMed

Gualdrini, G; Bedogni, R; Fantuzzi, E; Mariotti, F

2004-01-01

The present paper summarises the activity carried out at the ENEA Radiation Protection Institute for updating the methodologies employed for the evaluation of the neutron and photon dose to the exposed workers in case of a criticality accident, in the framework of the 'International Intercomparison of Criticality Accident Dosimetry Systems' (Silène reactor, IRSN-CEA-Valduc June 2002). The evaluation of the neutron spectra and the neutron dosimetric quantities relies on activation detectors and on unfolding algorithms. Thermoluminescent detectors are employed for the gamma dose measurement. The work is aimed at accurately characterising the measurement system and, at the same time, testing the algorithms. Useful spectral information were included, based on Monte Carlo simulations, to take into account the potential accident scenarios of practical interest. All along this exercise intercomparison a particular attention was devoted to the 'traceability' of all the experimental and computational parameters and therefore, aimed at an easy treatment by the user.

Conference report on the 3rd International Symposium on Lithium Application for Fusion Devices

DOE PAGES

Mazzitelli, Guiseppe; Hirooka, Y.; Hu, J. S.; ...

2015-01-14

The third International Symposium on Lithium Application for Fusion Device (ISLA-2013) was held on 9-11 October 2013 at ENEA Frascati Centre with growing participation and interest from the community working on more general aspect of liquid metal research for fusion energy development. ISLA-2013 has been confirmed to be the largest and the most important meeting dedicated to liquid metal application for the magnetic fusion research. Overall, 45 presentation plus 5 posters were given, representing 28 institutions from 11 countries. The latest experimental results from nine magnetic fusion devices were presented in 16 presentations from NSTX (PPPL, USA), FTU (ENEA, Italy),more » T-11M (Trinity, RF), T-10 (Kurchatov Institute, RF), TJ-II (CIEMAT, Spain), EAST(ASIPP, China), HT-7 (ASIPP, China), RFX (Padova, Italy), KTM (NNC RK, Kazakhstan). Sessions were devoted to the following: (I) lithium in magnetic confinement experiments (facility overviews), (II) lithium in magnetic confinement experiments (topical issues), (III) special session on liquid lithium technology, (IV) lithium laboratory test stands, (V) Lithium theory/modelling/comments, (VI) innovative lithium applications and (VII) special Session on lithium-safety and lithium handling. There was a wide participation from the fusion technology communities, including IFMIF and TBM communities providing productive exchange with the physics oriented magnetic confinement liquid metal research groups. Furthermore, this international workshop will continue on a biennial basis (alternating with the Plasma-Surface Interactions (PSI) Conference) and the next workshop will be held at CIEMAT, Madrid, Spain, in 2015.« less

Conference Report on the 3rd International Symposium on Lithium Application for Fusion Devices

NASA Astrophysics Data System (ADS)

Mazzitelli, G.; Hirooka, Y.; Hu, J. S.; Mirnov, S. V.; Nygren, R.; Shimada, M.; Ono, M.; Tabares, F. L.

2015-02-01

The third International Symposium on Lithium Application for Fusion Device (ISLA-2013) was held on 9-11 October 2013 at ENEA Frascati Centre with growing participation and interest from the community working on more general aspect of liquid metal research for fusion energy development. ISLA-2013 has been confirmed to be the largest and the most important meeting dedicated to liquid metal application for the magnetic fusion research. Overall, 45 presentation plus 5 posters were given, representing 28 institutions from 11 countries. The latest experimental results from nine magnetic fusion devices were presented in 16 presentations from NSTX (PPPL, USA), FTU (ENEA, Italy), T-11M (Trinity, RF), T-10 (Kurchatov Institute, RF), TJ-II (CIEMAT, Spain), EAST(ASIPP, China), HT-7 (ASIPP, China), RFX (Padova, Italy), KTM (NNC RK, Kazakhstan). Sessions were devoted to the following: (I) lithium in magnetic confinement experiments (facility overviews), (II) lithium in magnetic confinement experiments (topical issues), (III) special session on liquid lithium technology, (IV) lithium laboratory test stands, (V) Lithium theory/modelling/comments, (VI) innovative lithium applications and (VII) special Session on lithium-safety and lithium handling. There was a wide participation from the fusion technology communities, including IFMIF and TBM communities providing productive exchange with the physics oriented magnetic confinement liquid metal research groups. This international workshop will continue on a biennial basis (alternating with the Plasma-Surface Interactions (PSI) Conference) and the next workshop will be held at CIEMAT, Madrid, Spain, in 2015.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mazzitelli, Guiseppe; Hirooka, Y.; Hu, J. S.

The third International Symposium on Lithium Application for Fusion Device (ISLA-2013) was held on 9-11 October 2013 at ENEA Frascati Centre with growing participation and interest from the community working on more general aspect of liquid metal research for fusion energy development. ISLA-2013 has been confirmed to be the largest and the most important meeting dedicated to liquid metal application for the magnetic fusion research. Overall, 45 presentation plus 5 posters were given, representing 28 institutions from 11 countries. The latest experimental results from nine magnetic fusion devices were presented in 16 presentations from NSTX (PPPL, USA), FTU (ENEA, Italy),more » T-11M (Trinity, RF), T-10 (Kurchatov Institute, RF), TJ-II (CIEMAT, Spain), EAST(ASIPP, China), HT-7 (ASIPP, China), RFX (Padova, Italy), KTM (NNC RK, Kazakhstan). Sessions were devoted to the following: (I) lithium in magnetic confinement experiments (facility overviews), (II) lithium in magnetic confinement experiments (topical issues), (III) special session on liquid lithium technology, (IV) lithium laboratory test stands, (V) Lithium theory/modelling/comments, (VI) innovative lithium applications and (VII) special Session on lithium-safety and lithium handling. There was a wide participation from the fusion technology communities, including IFMIF and TBM communities providing productive exchange with the physics oriented magnetic confinement liquid metal research groups. Furthermore, this international workshop will continue on a biennial basis (alternating with the Plasma-Surface Interactions (PSI) Conference) and the next workshop will be held at CIEMAT, Madrid, Spain, in 2015.« less

MM-wave cyclotron auto-resonance maser for plasma heating

NASA Astrophysics Data System (ADS)

Ceccuzzi, S.; Dattoli, G.; Di Palma, E.; Doria, A.; Gallerano, G. P.; Giovenale, E.; Mirizzi, F.; Spassovsky, I.; Ravera, G. L.; Surrenti, V.; Tuccillo, A. A.

2014-02-01

Heating and Current Drive systems are of outstanding relevance in fusion plasmas, magnetically confined in tokamak devices, as they provide the tools to reach, sustain and control burning conditions. Heating systems based on the electron cyclotron resonance (ECRH) have been extensively exploited on past and present machines DEMO, and the future reactor will require high frequencies. Therefore, high power (≥1MW) RF sources with output frequency in the 200 - 300 GHz range would be necessary. A promising source is the so called Cyclotron Auto-Resonance Maser (CARM). Preliminary results of the conceptual design of a CARM device for plasma heating, carried out at ENEA-Frascati will be presented together with the planned R&D development.

Neutral atoms facility for space sensors characterization and BepiColombo/ELENA development instrument's progresses.

NASA Astrophysics Data System (ADS)

de Angelis, E.; di Lellis, A. M.; Orsini, S.; Zanza, V.; Maggi, M.; Vertolli, N.; D'Amicis, R.; Tilia, B.; Sibio, A.

2003-04-01

An Energetic Neutral Atoms facility to test and calibrate Neutral Atoms Analyzers has been developed in the Scientific Technical Unit of Fusion at the ENEA Research Center in Frascati (Rome-Italy). In the last years a collaboration with IFSI (Interplanetary Space and Physics Institute, CNR-Rome-Italy) has allowed to use this facility for space sensors and for characterization of crucial instruments elements. The ENA beam is realized with an ion source and a neutralization cell, and allows to test any instrument in the energy range 300eV-110keV with the available masses of Hydrogen, Deuterium or Helium. At the moment, the critical elements of ELENA (Emitted Low Energy Neutral Atoms) instrument proposed for BepiColombo ESA cornerstone mission to Mercury is under development testing. The facility, its potentiality and the instrument characterization progresses are presented.

Structural modeling of HTS tapes and cables

NASA Astrophysics Data System (ADS)

Allen, N. C.; Chiesa, L.; Takayasu, M.

2016-12-01

Structural finite element analysis (FEA) has been used as an insightful tool to investigate the electromechanical behavior of HTS REBCO tapes and twisted stacked-tape cables under tension, torsion, bending and combined loads. A novel technique was developed for modeling the layered composite structure of the 2G tapes with structural solid-shell elements in ANSYS®. The FEA models produced detailed strain information for the REBCO superconducting layer which was then paired with an analytical model to predict the critical current performance of the 2G HTS tapes under various loads. Two commercially available HTS tapes (SuperPower and SuNAM) under tension, torsion and combined tension-torsion were first analyzed with FEA and compared with available experimental results at 77 K. A sharp critical current degradation was experienced at the yield strength of the tapes under tension and below a 100 mm twist-pitch under torsion. Combined tension-torsion loads had a more gradual degradation of critical current for twist-pitches of 115 mm or shorter but had a negligible difference compared to pure tension for longer twist-pitches. Using the structural solid-shell technique for modeling 2G tapes in ANSYS®, an FEA methodology for simulating full scale three-dimensional HTS stacked-tape cables under pure bending was created. A model of a Twisted-Stacked Tape Cable (TSTC), a configuration first proposed at MIT, was initially developed and then adapted to the slotted-core HTS Cable-In-Conduit Conductor produced by the ENEA laboratory in Italy. The numerical axial strain of the HTS REBCO tapes within the cables as calculated by FEA were found to agree with an analytical model for two cases: perfect-slip (frictionless) and no-slip (bonded). The ENEA CICC model was also compared with recent experimental critical current data at 77 K and was found to match best using a low friction coefficient of 0.02 indicating that the tapes within the cable freely slide with respect to each other helping to reduce the axial strain during bending.

Kinetic parameters of the GUINEVERE reference configuration in VENUS-F reactor obtained from a pile noise experiment using Rossi and Feynman methods

DOE Office of Scientific and Technical Information (OSTI.GOV)

Geslot, Benoit; Pepino, Alexandra; Blaise, Patrick

A pile noise measurement campaign has been conducted by the CEA in the VENUS-F reactor (SCK-CEN, Mol Belgium) in April 2011 in the reference critical configuration of the GUINEVERE experimental program. The experimental setup made it possible to estimate the core kinetic parameters: the prompt neutron decay constant, the delayed neutron fraction and the generation time. A precise assessment of these constants is of prime importance. In particular, the effective delayed neutron fraction is used to normalize and compare calculated reactivities of different subcritical configurations, obtained by modifying either the core layout or the control rods position, with experimental onesmore » deduced from the analysis of measurements. This paper presents results obtained with a CEA-developed time stamping acquisition system. Data were analyzed using Rossi-α and Feynman-α methods. Results were normalized to reactor power using a calibrated fission chamber with a deposit of Np-237. Calculated factors were necessary to the analysis: the Diven factor was computed by the ENEA (Italy) and the power calibration factor by the CNRS/IN2P3/LPC Caen. Results deduced with both methods are consistent with respect to calculated quantities. Recommended values are given by the Rossi-α estimator, that was found to be the most robust. The neutron generation time was found equal to 0.438 ± 0.009 μs and the effective delayed neutron fraction is 765 ± 8 pcm. Discrepancies with the calculated value (722 pcm, calculation from ENEA) are satisfactory: -5.6% for the Rossi-α estimate and -2.7% for the Feynman-α estimate. (authors)« less

Progress on the accelerator based SPES-BNCT project at INFN Legnaro

DOE Office of Scientific and Technical Information (OSTI.GOV)

Esposito, J.; Colautti, P.; Pisent, A.

2007-02-12

In the framework of an advanced Exotic Ion Beam facility, named SPES (Study and Production of Exotic Species), that will allow a frontier program both in nuclear and interdisciplinary physics, an intense thermal neutron beam facility, devoted to perform Boron Neutron Capture Therapy (BNCT) experimental treatments on skin melanoma tumor, is currently under construction based on the SPES proton driver. A vast radiobiological investigation in vitro and in vivo has started with the new 10B carriers developed. Special microdosimetric detectors have been constructed to properly measure all the BNCT dose components and their qualities. Both microdosimetric and radiobiological measurements aremore » being performed at the new HYTHOR beam shaping assembly at the Enea-Casaccia TAPIRO reactor.« less

Airborne polar experiment (APE): tests and qualification of the scientific instrumentation installed on the stratospheric platform M-55 aircraft

NASA Astrophysics Data System (ADS)

de Rossi, Giuseppe; Puccini, Massimo; Puccetti, Giuseppe

1995-12-01

The paper describes the environmental tests to be carried out on the scientific instrumentation to be flown on the M-55 Geophysika in the frame of the APE Program. The instruments, developed by different European research institutes, are for remote sensing and in situ measurements of the major components of the Earth's stratosphere. The paper presents the technological activities that ENEA (Ente Nazionale per le Nuove Tecnologie l'Energia e l'Ambiente) is carrying out in its laboratories to verify the correspondence of the various instruments to meet the requirements for airborne application. The reference documents used have been the RTCA/DO-160C and the MDB (Myasishchev Design Bureau) specifications.

JPRS Report, West Europe.

DTIC Science & Technology

1987-07-07

bluish- tinted icebergs into the Disko Bay, from where they slowly waltz south past Christianshab. From the windows of their homes the population watch...expedition we have reached our political-diplomatic goal: to join the antartic advisory committee." Italy entered the race late," added ENEA President...interests, Antartic is in this sense a unique territory. It is the most important scientific laboratory in the world where scientific research

A digital acquisition and elaboration system for nuclear fast pulse detection

NASA Astrophysics Data System (ADS)

Esposito, B.; Riva, M.; Marocco, D.; Kaschuck, Y.

2007-03-01

A new digital acquisition and elaboration system has been developed and assembled in ENEA-Frascati for the direct sampling of fast pulses from nuclear detectors such as scintillators and diamond detectors. The system is capable of performing the digital sampling of the pulses (200 MSamples/s, 14-bit) and the simultaneous (compressed) data transfer for further storage and software elaboration. The design (FPGA-based) is oriented to real-time applications and has been developed in order to allow acquisition with no loss of pulses and data storage for long-time intervals (tens of s at MHz pulse count rates) without the need of large on-board memory. A dedicated pulse analysis software, written in LabVIEWTM, performs the treatment of the acquired pulses, including pulse recognition, pile-up rejection, baseline removal, pulse shape particle separation and pulse height spectra analysis. The acquisition and pre-elaboration programs have been fully integrated with the analysis software.

Phosphoric acid fuel cell 1.3 MW plant in Milan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Colombo, M.; Vigano, A.

1997-07-01

At the end of the 80`s Aem, ENEA and Ansaldo Ricerche began to design and build a 1.3 MW phosphoric-acid-fuel-cell power plant for the production of electrical power and heat; this plant was built and installed in the Bicocca site, in the north-east area of Milan, where a great development is being promoted. Aem has been taking over the plant since July 1995. Its aim is to test the extensively advantages of this technology for both conversion efficiency and low environmental impact. The experimentation will have to recognize the key elements in order to plan and create the multi-megawatt plantsmore » with the phosphoric acid technology, opening the experimentation to international partners, like users, industries and Universities interested in the development and the application of these new systems of energy cogeneration.« less

Laser photoacoustic system for characterization of climacteric and nonclimacteric fruits in postharvest

NASA Astrophysics Data System (ADS)

Giubileo, G.; Lai, A.; Piccinelli, D.; Puiu, A.

2005-06-01

The emission of ethylene from climacteric fruit banana (Musa x paradisiaca L.) and non climacteric fruits lemon (Citrus limon Burm. F.) at different stages of ripening (from a few days after setting to full maturity stage) by the Laser Photoacoustic Spectroscopy System, developed in ENEA Frascati, was measured. A high ethylene production rate from mature banana fruit was found, as expected for climacteric fruit. Significant differences between ethylene emitted by the lemon after setting stage and by the young fruit were observed. Also ethylene emission from lemon fruits at different ripening stages (from light green to turning and full ripe) was detected. Depending on the ripening stage, differences in ethylene emission rates were found, although the emissions were low as expected for non-climacteric fruit.

Design and realization of a 300 W fuel cell generator on an electric bicycle

NASA Astrophysics Data System (ADS)

Cardinali, Luciano; Santomassimo, Saverio; Stefanoni, Marco

At ENEA Casaccia Research Center (Rome, Italy) a 300 W NUVERA fuel cell stack has been utilized for the construction of a range extender generator on a commercial electric bicycle. The generator is fully automated with a programmable logic controller (PLC) safely operating start-up, shut-down and emergencies; a volumetric compressor supplies air to the cathode, a dc/dc converter transfers energy from the stack to the battery. All ancillary equipment are commercial; only the cell voltage sensors have been developed in order to obtain miniaturized and low consumption components. With this generator the bicycle nominal range of 25 km (utilizing only the Ni-Mh battery) is extended to over 120 km, by installing a 200 bar, 5 l bottle of hydrogen.

Proton beam spatial distribution and Bragg peak imaging by photoluminescence of color centers in lithium fluoride crystals at the TOP-IMPLART linear accelerator

NASA Astrophysics Data System (ADS)

Piccinini, M.; Ronsivalle, C.; Ampollini, A.; Bazzano, G.; Picardi, L.; Nenzi, P.; Trinca, E.; Vadrucci, M.; Bonfigli, F.; Nichelatti, E.; Vincenti, M. A.; Montereali, R. M.

2017-11-01

Solid-state radiation detectors based on the photoluminescence of stable point defects in lithium fluoride crystals have been used for advanced diagnostics during the commissioning of the segment up to 27 MeV of the TOP-IMPLART proton linear accelerator for proton therapy applications, under development at ENEA C.R. Frascati, Italy. The LiF detectors high intrinsic spatial resolution and wide dynamic range allow obtaining two-dimensional images of the beam transverse intensity distribution and also identifying the Bragg peak position with micrometric precision by using a conventional optical fluorescence microscope. Results of the proton beam characterization, among which, the estimation of beam energy components and dynamics, are reported and discussed for different operating conditions of the accelerator.

Monte Carlo determination of the conversion coefficients Hp(3)/Ka in a right cylinder phantom with 'PENELOPE' code. Comparison with 'MCNP' simulations.

PubMed

Daures, J; Gouriou, J; Bordy, J M

2011-03-01

This work has been performed within the frame of the European Union ORAMED project (Optimisation of RAdiation protection for MEDical staff). The main goal of the project is to improve standards of protection for medical staff for procedures resulting in potentially high exposures and to develop methodologies for better assessing and for reducing, exposures to medical staff. The Work Package WP2 is involved in the development of practical eye-lens dosimetry in interventional radiology. This study is complementary of the part of the ENEA report concerning the calculations with the MCNP-4C code of the conversion factors related to the operational quantity H(p)(3). In this study, a set of energy- and angular-dependent conversion coefficients (H(p)(3)/K(a)), in the newly proposed square cylindrical phantom made of ICRU tissue, have been calculated with the Monte-Carlo code PENELOPE and MCNP5. The H(p)(3) values have been determined in terms of absorbed dose, according to the definition of this quantity, and also with the kerma approximation as formerly reported in ICRU reports. At a low-photon energy (up to 1 MeV), the two results obtained with the two methods are consistent. Nevertheless, large differences are showed at a higher energy. This is mainly due to the lack of electronic equilibrium, especially for small angle incidences. The values of the conversion coefficients obtained with the MCNP-4C code published by ENEA quite agree with the kerma approximation calculations obtained with PENELOPE. We also performed the same calculations with the code MCNP5 with two types of tallies: F6 for kerma approximation and *F8 for estimating the absorbed dose that is, as known, due to secondary electrons. PENELOPE and MCNP5 results agree for the kerma approximation and for the absorbed dose calculation of H(p)(3) and prove that, for photon energies larger than 1 MeV, the transport of the secondary electrons has to be taken into account.

High resolution laser-based detection of ammonia

NASA Astrophysics Data System (ADS)

Giubileo, G.; Puiu, A.; Dell'Unto, F.; Tomasi, M.; Fagnani, A.

2009-02-01

In the present paper we compare the response of two types of photoacoustic cells (resonant and nonresonant) to determine the amount of ammonia volatilized from biological liquid samples at constant temperature, pressure and pH. The home made detector was a photoacoustic spectroscopy apparatus developed by Molecular Spectroscopy Laboratory staff at ENEA Frascati Research Centre in Italy. The sensor makes use of photo-acoustic cells equipped with commercially available high sensitivity miniaturized microphones. The radiation source was a line-tunable stabilized 10 W CW CO2 laser. Ammonia measurements were performed by tuning the laser source on the 9R30 laser line (9.2197 µm radiation wavelength). Ammonium chloride standard solutions were prepared by us in laboratory, to serve as reproducible ideal samples. The photoacoustic response of the two type of photoacoustic cells was determined and compared. The feasibility study was reported.

Scanning lidar fluorosensor for remote diagnostic of surfaces

NASA Astrophysics Data System (ADS)

Caneve, Luisa; Colao, Francesco; Fantoni, Roberta; Fiorani, Luca

2013-08-01

Scanning hyperspectral systems based on laser induced fluorescence (LIF) have been developed and realized at the ENEA allowing to obtain information of analytical and qualitative interest on different materials by the study of the emission of fluorescence. This technique, for a surface analysis, is fast, remote, not invasive and specific. A new compact setup capable of fast 2D monochromatic images acquisition on up to 90 different spectral channels in the visible/UV range will be presented. It has been recently built with the aim to increase the performances in terms of space resolution, time resolved capabilities and data acquisition speed. Major achievements have been reached by a critical review of the optical design. The results recently obtained with in-situ measurements of interest for applications in the field of cultural heritage will be shown. 2001 Elsevier Science. All rights reserved

A new passive radon-thoron discriminative measurement system.

PubMed

Sciocchetti, G; Sciocchetti, A; Giovannoli, P; DeFelice, P; Cardellini, F; Cotellessa, G; Pagliari, M

2010-10-01

A new passive radon-thoron discriminative measurement system has been developed for monitoring radon and thoron individually. It consists of a 'couple' of passive integrating devices with a CR39 nuclear track detector (NTD). The experimental prototype is based on the application of a new concept of NTD instrument developed at ENEA, named Alpha-PREM, acronym of piston radon exposure meter, which allows controlling the detector exposure with a patented sampling technique (Int. Eu. Pat. and US Pat.). The 'twin diffusion chambers system' was based on two A-PREM devices consisting of the standard device, named NTD-Rn, and a modified version, named NTD-Rn/Tn, which was set up to improve thoron sampling efficiency of the diffusion chamber, without changing the geometry and the start/stop function of the NTD-Rn device. Coupling devices fitted on each device allowed getting a system, which works as a double-chamber structure when deployed at the monitoring position. In this paper both technical and physical aspects are considered.

In field application of differential Die-Away time technique for detecting gram quantities of fissile materials

NASA Astrophysics Data System (ADS)

Remetti, Romolo; Gandolfo, Giada; Lepore, Luigi; Cherubini, Nadia

2017-10-01

In the frame of Chemical, Biological, Radiological, and Nuclear defense European activities, the ENEA, the Italian National Agency for New Technologies, Energy and Sustainable Economic Development, is proposing the Neutron Active Interrogation system (NAI), a device designed to find transuranic-based Radioactive Dispersal Devices hidden inside suspected packages. It is based on Differential Die-Away time Analysis, an active neutron technique targeted in revealing the presence of fissile material through detection of induced fission neutrons. Several Monte Carlo simulations, carried out by MCNPX code, and the development of ad-hoc design methods, have led to the realization of a first prototype based on a 14 MeV d-t neutron generator coupled with a tailored moderating structure, and an array of helium-3 neutron detectors. The complete system is characterized by easy transportability, light weight, and real-time response. First results have shown device's capability to detect gram quantities of fissile materials.

Cryogenic Testing of High Current By-Pass Diode Stacks for the Protection of the Superconducting Magnets in the LHC

NASA Astrophysics Data System (ADS)

Gharib, A.; Hagedorn, D.; Della Corte, A.; Fiamozzi Zignani, C.; Turtu, S.; Brown, D.; Rout, C.

2004-06-01

For the protection of the LHC superconducting magnets, about 2100 specially developed by-pass diodes were manufactured by DYNEX SEMICONDUCTOR LTD (Lincoln, GB) and about 1300 of these diodes were mounted into diode stacks and submitted to tests at cryogenic temperatures. To date about 800 dipole diode stacks and about 250 quadrupole diode stacks for the protection of the superconducting lattice dipole and lattice quadrupole magnets have been assembled at OCEM (Bologna,Italy) and successfully tested in liquid helium at ENEA (Frascati, Italy). This report gives an overview of the test results obtained so far. After a short description of the test installations and test procedures, a statistical analysis is presented for test data during diode production as well as for the performance of the diode stacks during testing in liquid helium, including failure rates and degradation of the diodes.

Plasma Wall interaction in the IGNITOR machine

NASA Astrophysics Data System (ADS)

Ferro, C.

1998-11-01

One of the critical issues in ignited machines is the management of the heat and particle exhaust without degradation of the plasma quality (pollution and confinement time) and without damage of the material facing the plasma. The IGNITOR machine has been conceived as a ``limiter" device, i.e., with the plasma leaning nearly on the entire surface of the first wall. Peak heat loads can easily be maintained at values lower than 1.35 MW/m^2 even considering displacements of the plasma column^1. This ``limiter" choice is based on the operational performances of high density, high field machines which suggests that intrinsic physics processes in the edge of the plasma are effective in spreading heat loads and maintaining the plasma pollution at a low level. The possibility of these operating scenarios has been demonstrated recently by different machines both in limiter and divertor configurations. The basis for the different physical processes that are expected to influence the IGNITOR edge parameters ^2 are discussed and a comparison with the latest experimental results is given. ^1 C. Ferro, G. Franzoni, R. Zanino, ENEA Internal Report RT/ERG/FUS/94/14. ^2 C. Ferro, R. Zanino, J. Nucl. Mater. 543, 176 (1990).

Imaging plates calibration to X-rays

NASA Astrophysics Data System (ADS)

Curcio, A.; Andreoli, P.; Cipriani, M.; Claps, G.; Consoli, F.; Cristofari, G.; De Angelis, R.; Giulietti, D.; Ingenito, F.; Pacella, D.

2016-05-01

The growing interest for the Imaging Plates, due to their high sensitivity range and versatility, has induced, in the last years, to detailed characterizations of their response function in different energy ranges and kind of radiation/particles. A calibration of the Imaging Plates BAS-MS, BAS-SR, BAS-TR has been performed at the ENEA-Frascati labs by exploiting the X-ray fluorescence of different targets (Ca, Cu, Pb, Mo, I, Ta) and the radioactivity of a BaCs source, in order to cover the X-ray range between few keV to 80 keV.

Lidar detection of carbon dioxide in volcanic plumes

NASA Astrophysics Data System (ADS)

Fiorani, Luca; Santoro, Simone; Parracino, Stefano; Maio, Giovanni; Del Franco, Mario; Aiuppa, Alessandro

2015-06-01

Volcanic gases give information on magmatic processes. In particular, anomalous releases of carbon dioxide precede volcanic eruptions. Up to now, this gas has been measured in volcanic plumes with conventional measurements that imply the severe risks of local sampling and can last many hours. For these reasons and for the great advantages of laser sensing, the thorough development of volcanic lidar has been undertaken at the Diagnostics and Metrology Laboratory (UTAPRAD-DIM) of the Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA). In fact, lidar profiling allows one to scan remotely volcanic plumes in a fast and continuous way, and with high spatial and temporal resolution. Two differential absorption lidar instruments will be presented in this paper: BILLI (BrIdge voLcanic LIdar), based on injection seeded Nd:YAG laser, double grating dye laser, difference frequency mixing (DFM) and optical parametric amplifier (OPA), and VULLI (VULcamed Lidar), based on injection seeded Nd:YAG laser and optical parametric oscillator (OPO). The first one is funded by the ERC (European Research Council) project BRIDGE and the second one by the ERDF (European Regional Development Fund) project VULCAMED. While VULLI has not yet been tested in a volcanic site, BILLI scanned the gas emitted by Pozzuoli Solfatara (Campi Flegrei volcanic area, Naples, Italy) during a field campaign carried out from 13 to 17 October 2014. Carbon dioxide concentration maps were retrieved remotely in few minutes in the crater area. Lidar measurements were in good agreement with well-established techniques, based on different operating principles. To our knowledge, it is the first time that carbon dioxide in a volcanic plume is retrieved by lidar, representing the first direct measurement of this kind ever performed on an active volcano and showing the high potential of laser remote sensing in geophysical research.

SPES-2, an experimental program to support the AP600 development

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tarantini, M.; Medich, C.

1995-09-01

In support of the development of the AP600 reactor, ENEA, ENEL, ANSALDO and Westinghouse have signed a research agreement. In the framework of this agreement a complex Full Height Full Pressure (FHFP) integral system testing program has been planned on SPES-2 facility. The main purpose of this paper is to point out the status of the test program; describe the hot per-operational test performed and the complete test matrix, giving all the necessary references on the work already published. Two identical Small Break LOCA transients, performed with Pressurizer to Core Make-up Tank (PRZ-CMT) balance line (Test S00203) and without PRZ-CMTmore » balance line (Test S00303) are then compared, to show how the SPES-2 facility can contribute in confirming the new AP600 reactor design choices and can give useful indications to designers. Although the detailed analysis of test data has not been completed, some consideration on the analytical tools utilized and on the SPES-2 capability to simulate the reference plant is then drawn.« less

Evaluation of a digital data acquisition system and optimization of n-γ discrimination for a compact neutron spectrometer.

PubMed

Giacomelli, L; Zimbal, A; Reginatto, M; Tittelmeier, K

2011-01-01

A compact NE213 liquid scintillation neutron spectrometer with a new digital data acquisition (DAQ) system is now in operation at the Physikalisch-Technische Bundesanstalt (PTB). With the DAQ system, developed by ENEA Frascati, neutron spectrometry with high count rates in the order of 5×10(5) s(-1) is possible, roughly an order of magnitude higher than with an analog acquisition system. To validate the DAQ system, a new data analysis code was developed and tests were done using measurements with 14-MeV neutrons made at the PTB accelerator. Additional analysis was carried out to optimize the two-gate method used for neutron and gamma (n-γ) discrimination. The best results were obtained with gates of 35 ns and 80 ns. This indicates that the fast and medium decay time components of the NE213 light emission are the ones that are relevant for n-γ discrimination with the digital acquisition system. This differs from what is normally implemented in the analog pulse shape discrimination modules, namely, the fast and long decay emissions of the scintillating light.

POSEIDON: An integrated system for analysis and forecast of hydrological, meteorological and surface marine fields in the Mediterranean area

NASA Astrophysics Data System (ADS)

Speranza, A.; Accadia, C.; Casaioli, M.; Mariani, S.; Monacelli, G.; Inghilesi, R.; Tartaglione, N.; Ruti, P. M.; Carillo, A.; Bargagli, A.; Pisacane, G.; Valentinotti, F.; Lavagnini, A.

2004-07-01

The Mediterranean area is characterized by relevant hydrological, meteorological and marine processes developing at horizontal space-scales of the order of 1-100 km. In the recent past, several international programs have been addressed (ALPEX, POEM, MAP, etc.) to "resolving" the dynamics of such motions. Other projects (INTERREG-Flooding, MEDEX, etc.) are at present being developed with special emphasis on catastrophic events with major impact on human society that are, quite often, characterized in their manifestation by processes with the above-mentioned scales of motion. In the dynamical evolution of such events, however, equally important is the dynamics of interaction of the local (and sometimes very damaging) processes with others developing at larger scales of motion. In fact, some of the most catastrophic events in the history of Mediterranean countries are associated with dynamical processes covering all the range of space-time scales from planetary to local. The Prevision Operational System for the mEditerranean basIn and the Defence of the lagOon of veNice (POSEIDON) is an integrated system for the analysis and forecast of hydrological, meteorological, oceanic fields specifically designed and set up in order to bridge the gap between global and local scales of motion, by modeling explicitly the above referred to dynamical processes in the range of scales from Mediterranean to local. The core of POSEIDON consists of a "cascade" of numerical models that, starting from global scale numerical analysis-forecast, goes all the way to very local phenomena, like tidal propagation in Venice Lagoon. The large computational load imposed by such operational design requires necessarily parallel computing technology: the first model in the cascade is a parallelised version of BOlogna Limited Area Model (BOLAM) running on a Quadrics 128 processors computer (also known as QBOLAM). POSEIDON, developed in the context of a co-operation between the Italian Agency for New technologies, Energy and Environment (Ente per le Nuove tecnologie, l'Energia e l'Ambiente, ENEA) and the Italian Agency for Environmental Protection and Technical Services (Agenzia per la Protezione dell'Ambiente e per i Servizi Tecnici, APAT), has become operational in 2000 and we are presently in the condition of drawing some preliminary conclusions about its performance. In the paper we describe the scientific concepts that were at the basis of the original planning, the structure of the system, its operational cycle and some preliminary scientific and technical evaluations after two years of experimentation.

Real Time Conference 2016 Overview

NASA Astrophysics Data System (ADS)

Luchetta, Adriano

2017-06-01

This is a special issue of the IEEE Transactions on Nuclear Science containing papers from the invited, oral, and poster presentation of the 20th Real Time Conference (RT2016). The conference was held June 6-10, 2016, at Centro Congressi Padova “A. Luciani,” Padova, Italy, and was organized by Consorzio RFX (CNR, ENEA, INFN, Università di Padova, Acciaierie Venete SpA) and the Istituto Nazionale di Fisica Nucleare. The Real Time Conference is multidisciplinary and focuses on the latest developments in real-time techniques in high-energy physics, nuclear physics, astrophysics and astroparticle physics, nuclear fusion, medical physics, space instrumentation, nuclear power instrumentation, general radiation instrumentation, and real-time security and safety. Taking place every second year, it is sponsored by the Computer Application in Nuclear and Plasma Sciences technical committee of the IEEE Nuclear and Plasma Sciences Society. RT2016 attracted more than 240 registrants, with a large proportion of young researchers and engineers. It had an attendance of 67 students from many countries.

Measurements of global UV irradiance at Terranova Bay, Antactica, by a home made narrow band filter radiometer

NASA Astrophysics Data System (ADS)

Salvatore, Scaglione; di Sarcina, Ilaria; Flori, Daniele; Menchini, Francesca

2010-05-01

Filter radiometers measure the solar radiation in several channels (typically 4 to 7) with a bandwith from 2 to 10 nm. They require less maintenance than the spectroradiometer and they are able to work in hostile environment as for instance the polar regions. The spectral resolution depends on the width at half maximum (FWHM) of the filters and is generally lower than the spectroradiometer resolution (0.5 nm). Other than the robustness of this instruments, the main advantage of the filter radiometers is the high frequency with which all wavelengths can be measured, making this class of instrument well suited for investigating short term irradiance variation. In this work is presented the results of UV irradiance measurements performed by a very narrow band (FWHM less than 1 nm) filter radiometer at Antarctica Italia Base, Mario Zucchelli Station, Terranova Bay, lat. 74° 41.6084' south and lon. 164° 05.9224' est. All-dielectric Fabry-Perot filters were manufactured in the laboratories of the Optical Coating Group, ENEA, by the ion beam assistance physical vapor deposition technique. Nine filters select nine different wavelengths in the UV spectral range from 296.5 nm to 377 nm with about 1 minute of measurement period, i.e. each wavelength is measured about 1250 times per day. At the moment the radiometer are permanently located near MZS and the data are daily downloaded in ENEA, Rome, by a dedicated satellite channel. During the Antarctica winter the radiometer will be in standby mode, in this season MZS is closed, and it will be start to measure again in the Antarctica spring.

TESPI (Tool for Environmental Sound Product Innovation): a simplified software tool to support environmentally conscious design in SMEs

NASA Astrophysics Data System (ADS)

Misceo, Monica; Buonamici, Roberto; Buttol, Patrizia; Naldesi, Luciano; Grimaldi, Filomena; Rinaldi, Caterina

2004-12-01

TESPI (Tool for Environmental Sound Product Innovation) is the prototype of a software tool developed within the framework of the "eLCA" project. The project, (www.elca.enea.it)financed by the European Commission, is realising "On line green tools and services for Small and Medium sized Enterprises (SMEs)". The implementation by SMEs of environmental product innovation (as fostered by the European Integrated Product Policy, IPP) needs specific adaptation to their economic model, their knowledge of production and management processes and their relationships with innovation and the environment. In particular, quality and costs are the main driving forces of innovation in European SMEs, and well known barriers exist to the adoption of an environmental approach in the product design. Starting from these considerations, the TESPI tool has been developed to support the first steps of product design taking into account both the quality and the environment. Two main issues have been considered: (i) classic Quality Function Deployment (QFD) can hardly be proposed to SMEs; (ii) the environmental aspects of the product life cycle need to be integrated with the quality approach. TESPI is a user friendly web-based tool, has a training approach and applies to modular products. Users are guided through the investigation of the quality aspects of their product (customer"s needs and requirements fulfilment) and the identification of the key environmental aspects in the product"s life cycle. A simplified check list allows analyzing the environmental performance of the product. Help is available for a better understanding of the analysis criteria. As a result, the significant aspects for the redesign of the product are identified.

A travelling standard for radiopharmaceutical production centres in Italy

NASA Astrophysics Data System (ADS)

Capogni, M.; de Felice, P.; Fazio, A.

Short-lived radionuclides, γ, β+ and/or β- emitters, such as 18F, and 99mTc, particularly useful for nuclear medicine applications, both diagnostic and in radiotherapy, can be produced with high-specific activity in a small biomedical cyclotron or by a radionuclide generator. While [18F]Fludeoxyglucose ([18F]FDG) is a widely used radiopharmaceutical for positron emission tomography, the development of innovative diagnostic techniques and therapies involves the use of new radio-labelled molecules and emerging radionuclides, such as 64Cu and 124I. During the last 3 years, an extensive supply of [18F]FDG was started by many production sites in Italy, and new radiopharmaceuticals are being studied for future nuclear medical applications. Therefore, a special nuclear medicine research programme for primary standard development and transferral to the end-users has been carried out by the ENEA-INMRI. Because of the short half-lives of these nuclides, a portable well-type ionisation chamber was established as a secondary travelling standard. This device has been calibrated and transported to the radiopharmaceutical production centres in Italy where the local instrumentation, typically radionuclide calibrators, has been calibrated by a simple comparison, with an uncertainty level lower than 2%.

STARDUST-U experiments on fluid-dynamic conditions affecting dust mobilization during LOVAs

NASA Astrophysics Data System (ADS)

Poggi, L. A.; Malizia, A.; Ciparisse, J. F.; Tieri, F.; Gelfusa, M.; Murari, A.; Del Papa, C.; Giovannangeli, I.; Gaudio, P.

2016-07-01

Since 2006 the Quantum Electronics and Plasma Physics (QEP) Research Group together with ENEA FusTech of Frascati have been working on dust re-suspension inside tokamaks and its potential capability to jeopardize the integrity of future fusion nuclear plants (i.e. ITER or DEMO) and to be a risk for the health of the operators. Actually, this team is working with the improved version of the "STARDUST" facility, i.e. "STARDUST-Upgrade". STARDUST-U facility has four new air inlet ports that allow the experimental replication of Loss of Vacuum Accidents (LOVAs). The experimental campaign to detect the different pressurization rates, local air velocity, temperature, have been carried out from all the ports in different accident conditions and the principal results will be analyzed and compared with the numerical simulations obtained through a CFD (Computational Fluid Dynamic) code. This preliminary thermo fluid-dynamic analysis of the accident is crucial for numerical model development and validation, and for the incoming experimental campaign of dust resuspension inside STARDUST-U due to well-defined accidents presented in this paper.

Neutron Data Compilation Centre, European Nuclear Energy Agency, Newsletter No. 13

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1972-02-15

This edition of the newsletter is intended to inform all users of neutron data about the content of the CCDN Experimental Neutron Data Library as of February 1972. It supercedes the last index issue, no. 11, published in October 1969. Since then, the database has been greatly enlarged thanks to the collaboration of neutron data users in the ENEA area (Western Europe plus Japan) and to the truly worldwide cooperation between the four existing data centers: NNCSC at Brookhaven Lab. in Upton, NY, United States, CCDN in Gif-sur_yvette, France, Centr po Jadernym Dannym in Obninsk, USSR, and the Nuclear Datamore » Section, IAEA, Vienna, Austria.« less

A new protocol in La Spezia for elementary and secondary school students for monitoring Perception towards Science and Performance in Science Classrooms

NASA Astrophysics Data System (ADS)

Stroobant, Mascha; Mori, Anna; Merlino, Silvia; Bianucci, Marco; Delfanti, Roberta; Furia, Stefania; Carmisciano, Cosmo; Locritani, Marina; Muccini, Filippo; La Tassa, Hebert; Talamoni, Roberta; Nacini, Francesca; Benedetti, Alessandro; Nardi, Elisabetta; Parodi, Alice; Giacomazzi, Fabio; Mioni, Erika; Associazione Festival della Scienza

2014-05-01

Technological and scientific research in La Spezia (an Italian town with a population of 95.378) is, unfortunately, unknown to most people and often the existence of excellent research Centres (such as CNR-ISMAR, CNR-IENI, ENEA-UTMAR, INGV, CMRE, CSSN and University) is barely known, even just outside the La Spezia area. The current economic crisis has played a major role in determining the decline in maritime business (affecting all companies in the area and particularly SMEs). Therefore it is important to re-establish the relationship with the traditional maritime culture of the city. This objective can be achieved by enhancing research visibility (national and european) by dissemination of the activities carried out by research institutions, university and local enterprises. La Spezia has a long maritime tradition and it is vital for these customs to be kept alive and cultivated within the community. The cultural scene is positive: in fact, in the last decade the general public's perception on the importance of science in the context of human activities has been considerably strengthened. In La Spezia, especially since 2007, an increasing number of disseminating activities (carried out by CNR-ISMAR, CNR-IENI, ENEA-UTMAR, INGV, CMRE, CSSN, LABTER - the La Spezia association for environmental education- ASSOCIAZIONE FESTIVAL DELLA SCIENZA - the association that organizes the Genoa Science Festival- Genoa University and ISA 2 - "2 GIUGNO" - a local primary and secondary public school that has started a pilot project for marine biology), has revealed an educational and cultural path which now requires a monitoring protocol to be carried out for at least two years. In this paper we will present a new test that will be administered to the entire student population (aged 6 to 18 years) with the aim to fully understand the effectiveness of initiatives for popularizing science and the impact that they are having on new generations (professional choices, scientific careers, environmental awareness, etc..).

Analysis of unmitigated large break loss of coolant accidents using MELCOR code

NASA Astrophysics Data System (ADS)

Pescarini, M.; Mascari, F.; Mostacci, D.; De Rosa, F.; Lombardo, C.; Giannetti, F.

2017-11-01

In the framework of severe accident research activity developed by ENEA, a MELCOR nodalization of a generic Pressurized Water Reactor of 900 MWe has been developed. The aim of this paper is to present the analysis of MELCOR code calculations concerning two independent unmitigated large break loss of coolant accident transients, occurring in the cited type of reactor. In particular, the analysis and comparison between the transients initiated by an unmitigated double-ended cold leg rupture and an unmitigated double-ended hot leg rupture in the loop 1 of the primary cooling system is presented herein. This activity has been performed focusing specifically on the in-vessel phenomenology that characterizes this kind of accidents. The analysis of the thermal-hydraulic transient phenomena and the core degradation phenomena is therefore here presented. The analysis of the calculated data shows the capability of the code to reproduce the phenomena typical of these transients and permits their phenomenological study. A first sequence of main events is here presented and shows that the cold leg break transient results faster than the hot leg break transient because of the position of the break. Further analyses are in progress to quantitatively assess the results of the code nodalization for accident management strategy definition and fission product source term evaluation.

Membrane electrode gasket assembly (MEGA) technology for polymer electrolyte fuel cells

NASA Astrophysics Data System (ADS)

Pozio, A.; Giorgi, L.; De Francesco, M.; Silva, R. F.; Lo Presti, R.; Danzi, A.

A new technology for the production of a membrane electrode gasket assembly (MEGA) for polymer electrolyte fuel cells (PEFCs) is defined. The MEGA system was prepared by sealing a previously prepared membrane electrode assembly (MEA) in a moulded gasket. For this aim, a proprietary silicone based liquid mixture was injected directly into the MEA borders. Gaskets obtained in different shapes and hardness grades are stable in a wide temperature range. The MEGA technology shows several advantages with respect to traditional PEFCs stack assembling systems: effective membrane saving, reduced fabrication time, possibility of quality control and failed elements substitution. This technology was successfully tested at the ENEA laboratories and the results were acquired in laboratory scale, but industrial production appears to be simple and cheap.

Laser Irradiated Foam Targets: Absorption and Radiative Properties

NASA Astrophysics Data System (ADS)

Salvadori, Martina; Luigi Andreoli, Pier; Cipriani, Mattia; Consoli, Fabrizio; Cristofari, Giuseppe; De Angelis, Riccardo; di Giorgio, Giorgio; Giulietti, Danilo; Ingenito, Francesco; Gus'kov, Sergey Yu.; Rupasov, Alexander A.

2018-01-01

An experimental campaign to characterize the laser radiation absorption of foam targets and the subsequent emission of radiation from the produced plasma was carried out in the ABC facility of the ENEA Research Center in Frascati (Rome). Different targets have been used: plastic in solid or foam state and aluminum targets. The activated different diagnostics allowed to evaluate the plasma temperature, the density distribution, the fast particle spectrum and the yield of the X-Ray radiation emitted by the plasma for the different targets. These results confirm the foam homogenization action on laser-plasma interaction, mainly attributable to the volume absorption of the laser radiation propagating in such structured materials. These results were compared with simulation absorption models of the laser propagating into a foam target.

Application of MELCOR Code to a French PWR 900 MWe Severe Accident Sequence and Evaluation of Models Performance Focusing on In-Vessel Thermal Hydraulic Results

DOE Office of Scientific and Technical Information (OSTI.GOV)

De Rosa, Felice

2006-07-01

In the ambit of the Severe Accident Network of Excellence Project (SARNET), funded by the European Union, 6. FISA (Fission Safety) Programme, one of the main tasks is the development and validation of the European Accident Source Term Evaluation Code (ASTEC Code). One of the reference codes used to compare ASTEC results, coming from experimental and Reactor Plant applications, is MELCOR. ENEA is a SARNET member and also an ASTEC and MELCOR user. During the first 18 months of this project, we performed a series of MELCOR and ASTEC calculations referring to a French PWR 900 MWe and to themore » accident sequence of 'Loss of Steam Generator (SG) Feedwater' (known as H2 sequence in the French classification). H2 is an accident sequence substantially equivalent to a Station Blackout scenario, like a TMLB accident, with the only difference that in H2 sequence the scram is forced to occur with a delay of 28 seconds. The main events during the accident sequence are a loss of normal and auxiliary SG feedwater (0 s), followed by a scram when the water level in SG is equal or less than 0.7 m (after 28 seconds). There is also a main coolant pumps trip when {delta}Tsat < 10 deg. C, a total opening of the three relief valves when Tric (core maximal outlet temperature) is above 603 K (330 deg. C) and accumulators isolation when primary pressure goes below 1.5 MPa (15 bar). Among many other points, it is worth noting that this was the first time that a MELCOR 1.8.5 input deck was available for a French PWR 900. The main ENEA effort in this period was devoted to prepare the MELCOR input deck using the code version v.1.8.5 (build QZ Oct 2000 with the latest patch 185003 Oct 2001). The input deck, completely new, was prepared taking into account structure, data and same conditions as those found inside ASTEC input decks. The main goal of the work presented in this paper is to put in evidence where and when MELCOR provides good enough results and why, in some cases mainly referring to its specific models (candling, corium pool behaviour, etc.) they were less good. A future work will be the preparation of an input deck for the new MELCOR 1.8.6. and to perform a code-to-code comparison with ASTEC v1.2 rev. 1. (author)« less

The radiation fields around a proton therapy facility: A comparison of Monte Carlo simulations

NASA Astrophysics Data System (ADS)

Ottaviano, G.; Picardi, L.; Pillon, M.; Ronsivalle, C.; Sandri, S.

2014-02-01

A proton therapy test facility with a beam current lower than 10 nA in average, and an energy up to 150 MeV, is planned to be sited at the Frascati ENEA Research Center, in Italy. The accelerator is composed of a sequence of linear sections. The first one is a commercial 7 MeV proton linac, from which the beam is injected in a SCDTL (Side Coupled Drift Tube Linac) structure reaching the energy of 52 MeV. Then a conventional CCL (coupled Cavity Linac) with side coupling cavities completes the accelerator. The linear structure has the important advantage that the main radiation losses during the acceleration process occur to protons with energy below 20 MeV, with a consequent low production of neutrons and secondary radiation. From the radiation protection point of view the source of radiation for this facility is then almost completely located at the final target. Physical and geometrical models of the device have been developed and implemented into radiation transport computer codes based on the Monte Carlo method. The scope is the assessment of the radiation field around the main source for supporting the safety analysis. For the assessment independent researchers used two different Monte Carlo computer codes named FLUKA (FLUktuierende KAskade) and MCNPX (Monte Carlo N-Particle eXtended) respectively. Both are general purpose tools for calculations of particle transport and interactions with matter, covering an extended range of applications including proton beam analysis. Nevertheless each one utilizes its own nuclear cross section libraries and uses specific physics models for particle types and energies. The models implemented into the codes are described and the results are presented. The differences between the two calculations are reported and discussed pointing out disadvantages and advantages of each code in the specific application.

Experimental and numerical analysis of interfilament resistances in NbTi strands

NASA Astrophysics Data System (ADS)

Breschi, M.; Massimini, M.; Ribani, P. L.; Spina, T.; Corato, V.

2014-05-01

Superconducting strands are composite wires made of fine superconducting filaments embedded in a metallic matrix. The transverse resistivity among superconducting filaments affects the coupling losses during electromagnetic transients and the electro-thermal behavior of the wire in case of a quench. A direct measurement of the transverse interfilament resistance as a function of temperature in NbTi multi-filamentary wires was performed at the ENEA Frascati Superconductivity Division, Italy by means of a four-probe method. The complexity of these measurements is remarkable, due to the current distribution phenomena that occur among superconducting filaments during these tests. A two-dimensional finite element method model of the wire cross section and a three-dimensional electrical circuit model of the wire sample developed at the University of Bologna are applied here to derive qualitative and quantitative information about the transverse electrical resistance matrix. The experiment is aimed at verifying the qualitative behaviors and trends predicted by the numerical calculations, especially concerning the current redistribution length and consequent length effects of the sample under test. A fine tuning of the model parameters at the filament level allowed us to reproduce the experimental results and get quantitative information about the current distribution phenomena between filaments.

Phase-Sensitive Reflective Imaging Device in the mm-wave and Terahertz Regions

NASA Astrophysics Data System (ADS)

Gallerano, Gian Piero; Doria, Andrea; Germini, Marzia; Giovenale, Emilio; Messina, Giovanni; Spassovsky, Ivan P.

2009-12-01

Two Free Electron Laser sources have been developed at ENEA-Frascati for a variety of applications: A Compact Free Electron Laser (C-FEL) that provides coherent radiation in the frequency range between 90 and 150 GHz Gallerano et al. (Infrared Phys. and Techn. 40:161, 1999), and a second source, FEL-CATS, which utilizes a peculiar radio-frequency structure to generate coherent emission in the range 0.4 to 0.7 THz Doria et al. (Phys. Rev. Lett 93:264801, 2004). The high peak power of several kW in 15 to 50 ps pulses, makes these sources particularly suitable for the assessment of exposure limits in biological systems and for long range detection. In this paper we present a phase-sensitive reflective imaging device in the mm-wave and THz regions, which has proven to be a valuable tool in the biological Ramundo-Orlando et al. (Bioelectromagnetics 28:587-598, 2007), environmental Doria et al. (2005) and art conservation fields Gallerano et al. (2008). Different setups have been tested at different levels of spatial resolution to image objects from a few centimeter square to larger sizes. Images have been compared to identify and characterize the contrast mechanism.

Leak-Before-Break: Further developments in regulatory policies and supporting research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilkowski, G.M.; Chao, K.-S.

1990-02-01

The fourth in a series of international Leak-Before-Break (LBB) Seminars supported in part by the US Nuclear Regulatory Commission was held at the National Central Library in Taipei, Taiwan on May 11 and 12, 1989. The seminar updated the international polices and supporting research on LBB. Attendees included representatives from regulatory agencies, electric utilities, nuclear power plant fabricators, research organizations, and academic institutions. Regulatory policy was the subject of presentations by Mr. G. Arlotto (US NRC, USA) Dr. B. Jarman (AECB, Canada), Dr.P. Milella (ENEA-DISP, Italy), Dr. C. Faidy (EDF/Septen, France ), and Dr. K. Takumi (NUPEC, Japan). A papermore » by Mr. K. Wichman and Mr. A. Lee of the US NRC Office of Nuclear Reactor Regulation is included as background material to these proceedings; it discusses the history and status of LBB applications in US nuclear power plants. In addition, several papers on the supporting research programs described regulatory policy or industry standards for flaw evaluations, e.g., the ASME Section XI code procedures. Supporting research programs were reviewed on the first and second day by several participants from Taiwan, US, Japan, Canada, Italy, and France. Each individual paper has been cataloged separately.« less

Results for the response function determination of the Compact Neutron Spectrometer

NASA Astrophysics Data System (ADS)

Gagnon-Moisan, F.; Reginatto, M.; Zimbal, A.

2012-03-01

The Compact Neutron Spectrometer (CNS) is a Joint European Torus (JET) Enhancement Project, designed for fusion diagnostics in different plasma scenarios. The CNS is based on a liquid scintillator (BC501A) which allows good discrimination between neutron and gamma radiation. Neutron spectrometry with a BC501A spectrometer requires the use of a reliable, fully characterized detector. The determination of the response matrix was carried out at the Ion Accelerator Facility (PIAF) of the Physikalisch-Technische Bundesanstalt (PTB). This facility provides several monoenergetic beams (2.5, 8, 10, 12 and 14 MeV) and a white field (Emax ~ 17 MeV), which allows for a full characterization of the spectrometer in the region of interest (from ~ 1.5 MeV to ~ 17 MeV). The energy of the incoming neutrons was determined by the time of flight method (TOF), with time resolution in the order of 1 ns. To check the response matrix, the measured pulse height spectra were unfolded with the code MAXED and the resulting energy distributions were compared with those obtained from TOF. The CNS project required modification of the PTB BC501A spectrometer design, to replace an analog data acquisition system (NIM modules) with a digital system developed by the Ente per le Nuove tecnologie, l'Energia e l'Ambiente (ENEA). Results for the new digital system were evaluated using new software developed specifically for this project.

ANITA-IEAF activation code package - updating of the decay and cross section data libraries and validation on the experimental data from the Karlsruhe Isochronous Cyclotron

NASA Astrophysics Data System (ADS)

Frisoni, Manuela

2017-09-01

ANITA-IEAF is an activation package (code and libraries) developed in the past in ENEA-Bologna in order to assess the activation of materials exposed to neutrons with energies greater than 20 MeV. An updated version of the ANITA-IEAF activation code package has been developed. It is suitable to be applied to the study of the irradiation effects on materials in facilities like the International Fusion Materials Irradiation Facility (IFMIF) and the DEMO Oriented Neutron Source (DONES), in which a considerable amount of neutrons with energies above 20 MeV is produced. The present paper summarizes the main characteristics of the updated version of ANITA-IEAF, able to use decay and cross section data based on more recent evaluated nuclear data libraries, i.e. the JEFF-3.1.1 Radioactive Decay Data Library and the EAF-2010 neutron activation cross section library. In this paper the validation effort related to the comparison between the code predictions and the activity measurements obtained from the Karlsruhe Isochronous Cyclotron is presented. In this integral experiment samples of two different steels, SS-316 and F82H, pure vanadium and a vanadium alloy, structural materials of interest in fusion technology, were activated in a neutron spectrum similar to the IFMIF neutron field.

SeaDataNet : Pan-European infrastructure for marine and ocean data management - Project objectives, structure and components

NASA Astrophysics Data System (ADS)

Maudire, G.; Maillard, C.; Fichaut, M.; Manzella, G.; Schaap, D. M. A.

2009-04-01

SeaDataNet : Pan-European infrastructure for marine and ocean data management Project objectives, structure and components G. Maudire (1), C. Maillard (1), G. Manzella (2), M. Fichaut (1), D.M.A. Schaap (3), E. Iona (4) and the SeaDataNet consortium. (1) IFREMER, Brest, France (Gilbert.Maudire@ifremer.fr), (2) ENEA, La Spezia, Italy, (3) Mariene Informatie Service 'MARIS', Voorburg, The Netherlands, (4) Hellenic Centre for Marine Research-HCMR, Anavyssos, Greece. Since a large part of the earth population lives near the oceans or carries on activities directly or indirectly linked to the seas (fishery and aquaculture, exploitation of sea bottom resources, international shipping, tourism), knowledge of oceans is of primary importance for security and economy. However, observation and monitoring of the oceans remains difficult and expensive even if real improvements have been achieved using research vessels and submersibles, satellites and automatic observatories like buoys, floats and seafloor observatories transmitting directly to the shore using global transmission systems. More than 600 governmental or private organizations are active in observation of seas bordering Europe, but European oceanographic data are fragmented, not always validated and not always easily accessible. That highlights the need of international collaboration to tend toward a comprehensive view of ocean mechanisms, resources and changes. SeaDataNet is an Integrated research Infrastructure Initiative (I3) in European Union Framework Program 6 (2006 - 2011) to provide the data management system adapted both to the fragmented observation systems and to the users need for an integrated access to data, meta-data, products and services. Its major objectives are to: - encourage long-term archiving at national level to secure ocean data taking into account that all the observations made in the variable oceanic environment can never be remade if they are lost; - promote best practices for data management, taking benefits of the development of international initiatives and standards on data quality insurance, data descriptions (metadata and common vocabulary) and interoperability. Software tools are developed or adapted accordingly to support these practices and the adoption of standards; - establish online services to facilitate data discovery, data requests, data visualisation and data download for the users; - process data sets of reference like ocean climatologies at a regional basin scale to provide comprehensive data sets Sustainability of the provided services is researched by a balance between the activities mostly undertaken at National level by the National Oceanographic data centres or some thematic data centres and the effort done at the Pan-European level by the project. The SeaDataNet consortium brings now together a unique group of 49 partners from major oceanographic institutes of 35 countries. Taking in account that valuable work on ocean data management must be done at basin level, most of countries bordering Black Sea, Mediterranean Sea, North-East Atlantic, North Sea, Baltic Sea and Artic Sea are part of the project. Capacity building of consortium members is necessary to meet project objectives and a comprehensive training program is conducted both for data management and for IT technologies which are necessary to establish such a distributed system: databases management, XML language, web portal and services, GIS technologies. SeaDataNet Partners: IFREMER (France), MARIS (Netherlands), HCMR/HNODC (Greece), ULg (Belgium), OGS (Italy),NERC/BODC (UK), BSH/DOD (Germany), SMHI (Sweden), IEO (Spain), RIHMI/WDC (Russia), IOC (International), ENEA (Italy), INGV (Italy), METU (Turkey), CLS (France), AWI (Germany), IMR (Norway), NERI (Denmark), ICES (International), EC-DG JRC (International), MI (Ireland), IHPT (Portugal), RIKZ (Netherlands), RBINS/MUMM (Belgium), VLIZ (Belgium), MRI (Iceland), FIMR (Finland ), IMGW (Poland), MSI (Estonia), IAE/UL (Latvia), CMR (Lithuania), SIO/RAS (Russia), MHI/DMIST (Ukraine), IO/BAS (Bulgaria), NIMRD (Romania), TSU (Georgia), INRH (Morocco), IOF (Croatia), PUT (Albania), NIB (Slovenia), UoM (Malta), OC/UCY (Cyprus), IOLR (Israel), NCSR/NCMS (Lebanon), CNR-ISAC (Italy), ISMAL (Algeria), INSTM (Tunisia)

Workplace testing of the new single sphere neutron spectrometer based on Dysprosium activation foils (Dy-SSS)

NASA Astrophysics Data System (ADS)

Bedogni, R.; Gómez-Ros, J. M.; Esposito, A.; Gentile, A.; Chiti, M.; Palacios-Pérez, L.; Angelone, M.; Tana, L.

2012-08-01

A photon insensitive passive neutron spectrometer consisting of a single moderating polyethylene sphere with Dysprosium activation foils arranged along three perpendicular axes was designed by CIEMAT and INFN. The device is called Dy-SSS (Dy foil-based Single Sphere Spectrometer). It shows nearly isotropic response in terms of neutron fluence up to 20 MeV. The first prototype, previously calibrated with 14 MeV neutrons, has been recently tested in workplaces having different energy and directional distributions. These are a 2.5 MeV nearly mono-chromatic and mono-directional beam available at the ENEA Frascati Neutron Generator (FNG) and the photo-neutron field produced in a 15 MV Varian CLINAC DHX medical accelerator, located in the Ospedale S. Chiara (Pisa). Both neutron spectra are known through measurements with a Bonner Sphere Spectrometer. In both cases the experimental response of the Dy-SSS agrees with the reference data. Moreover, it is demonstrated that the spectrometric capability of the new device are independent from the directional distribution of the neutron field. This opens the way to a new generation of moderation-based neutron instruments, presenting all advantages of the Bonner sphere spectrometer without the disadvantage of the repeated exposures. This concept is being developed within the NESCOFI@BTF project of INFN (Commissione Scientifica Nazionale 5).

Accelerated aging tests on ENEA-ASE solar coating for receiver tube suitable to operate up to 550 °C

NASA Astrophysics Data System (ADS)

Antonaia, A.; D'Angelo, A.; Esposito, S.; Addonizio, M. L.; Castaldo, A.; Ferrara, M.; Guglielmo, A.; Maccari, A.

2016-05-01

A patented solar coating for evacuated receiver, based on innovative graded WN-AlN cermet layer, has been optically designed and optimized to operate at high temperature with high performance and high thermal stability. This solar coating, being designed to operate in solar field with molten salt as heat transfer fluid, has to be thermally stable up to the maximum temperature of 550 °C. With the aim of determining degradation behaviour and lifetime prediction of the solar coating, we chose to monitor the variation of the solar absorptance αs after each thermal annealing cycle carried out at accelerated temperatures under vacuum. This prediction method was coupled with a preliminary Differential Thermal Analysis (DTA) in order to give evidence for any chemical-physical coating modification in the temperature range of interest before performing accelerated aging tests. In the accelerated aging tests we assumed that the temperature dependence of the degradation processes could be described by Arrhenius behaviour and we hypothesized that a linear correlation occurs between optical parameter variation rate (specifically, Δαs/Δt) and degradation process rate. Starting from Δαs/Δt values evaluated at 650 and 690 °C, Arrhenius plot gave an activation energy of 325 kJ mol-1 for the degradation phenomenon, where the prediction on the coating degradation gave a solar absorptance decrease of only 1.65 % after 25 years at 550 °C. This very low αs decrease gave evidence for an excellent stability of our solar coating, also when employed at the maximum temperature (550 °C) of a solar field operating with molten salt as heat transfer fluid.

LBE water interaction in sub-critical reactors: First experimental and modelling results

NASA Astrophysics Data System (ADS)

Ciampichetti, A.; Agostini, P.; Benamati, G.; Bandini, G.; Pellini, D.; Forgione, N.; Oriolo, F.; Ambrosini, W.

2008-06-01

This paper concerns the study of the phenomena involved in the interaction between LBE and pressurised water which could occur in some hypothetical accidents in accelerator driven system type reactors. The LIFUS 5 facility was designed and built at ENEA-Brasimone to reproduce this kind of interaction in a wide range of conditions. The first test of the experimental program was carried out injecting water at 70 bar and 235 °C in a reaction vessel containing LBE at 1 bar and 350 °C. A pressurisation up to 80 bar was observed in the test section during the considered transient. The SIMMER III code was used to simulate the performed test. The calculated data agree in a satisfactory way with the experimental results giving confidence in the possibility to use this code for safety analyses of heavy liquid metal cooled reactors.

Radon gamma-ray spectrometry with YAP:Ce scintillator

NASA Astrophysics Data System (ADS)

Plastino, Wolfango; De Felice, Pierino; de Notaristefani, Francesco

2002-06-01

The detection properties of a YAP:Ce scintillator (YAlO 3:Ce crystal) optically coupled to a Hamamatsu H5784 photomultiplier with standard bialkali photocathode have been analyzed. In particular, the application to radon and radon-daughters gamma-ray spectrometry was investigated. The crystal response has been studied under severe extreme conditions to simulate environments of geophysical interest, particularly those found in geothermal and volcanic areas. Tests in water up to a temperature of 100°C and in acids solutions such as HCl (37%), H 2SO 4 (48%) and HNO 3 (65%) have been performed. The measurements with standard radon sources provided by the National Institute for Metrology of Ionizing Radiations (ENEA) have emphasized the non-hygroscopic properties of the scintillator and a small dependence of the light yield on temperature and HNO 3. The data collected in this first step of our research have pointed out that the YAP:Ce scintillator can allow high response stability for radon gamma-ray spectrometry in environments with large temperature gradients and high acid concentrations.

International Conference on Infrared and Millimeter Waves, 18th, Univ. of Essex, Colchester, United Kingdom, Sept. 6-10, 1993, Conference Digest

NASA Astrophysics Data System (ADS)

Birch, James R.; Parker, Terence J.

Papers presented in these proceedings are grouped under the topics of FEL, detectors and sources, gas lasers, spectroscopy, windows for high-power applications, scattering, plasma diagnostics, waveguides, gyrotron, quasi-optical components, biological effects of IR and millimeter waves, and astronomical and atmospheric systems. Particular attention is given to the ENEA compact millimeter wave FEL, excitonic detectors of IR and submm waves, identification of submm CD2O lines, a two-frequency quasi-optical radiospectrometer for substance investigations, the effect of window tolerances on gyrotron performance, and analysis of scattering of the open resonator field from the cavity-backed aperture. Other papers are on submm laser interferometer-polarimeter for plasma diagnostics, the characteristics of the closed circular groove guide, a kW sixth-harmonic gyrofrequency multiplier, rugged FIR bandpass filters, millimeter waves and quantum medicines, and a horizontal atmospheric temperature sounder based on the 60-GHz oxygen absorptions.

Scenedesmus dimorphus (Turpin) Kützing growth with digestate from biogas plant in outdoor bag photobioreactors.

PubMed

Barbato, F; Venditti, A; Bianco, A; Guarcini, L; Bottari, E; Festa, M R; Cogliani, E; Pignatelli, V

2016-01-01

Digestate coming from an Anaerobic Digestion unit in a Biogas Plant, feeded on cow manure and vegetable waste from markets, has been used. About 8-35 L polyethylene transparent bags have been employed as cultivation container, outdoor. Different aliquots of digestate, alone or mixed with commercial liquid fertiliser, were employed to cultivate in batch Scenedesus dimorphus, a freshwater green microalga, in the ENEA facilities of Casaccia Research Center, near Rome, Italy. The cultivation period was June-July 2013. The average daily yields of dry microalgae biomass varied from 20 mg/L/d to 60 mg/L/d, mean 38.2 mg/L/d. Final dry biomass concentration varied from 0.18 to 1.29 g/L, mean 0.55 g/L. S. dimorphus proved to be very efficient in removing N and P from the culture medium. Another fact emerged from these trials is that S. dimorphus inner composition resulted to be variable in response to the tested different culture conditions.

Absolute reactivity calibration of accelerator-driven systems after RACE-T experiments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jammes, C. C.; Imel, G. R.; Geslot, B.

2006-07-01

The RACE-T experiments that were held in november 2005 in the ENEA-Casaccia research center near Rome allowed us to improve our knowledge of the experimental techniques for absolute reactivity calibration at either startup or shutdown phases of accelerator-driven systems. Various experimental techniques for assessing a subcritical level were inter-compared through three different subcritical configurations SC0, SC2 and SC3, about -0.5, -3 and -6 dollars, respectively. The area-ratio method based of the use of a pulsed neutron source appears as the most performing. When the reactivity estimate is expressed in dollar unit, the uncertainties obtained with the area-ratio method were lessmore » than 1% for any subcritical configuration. The sensitivity to measurement location was about slightly more than 1% and always less than 4%. Finally, it is noteworthy that the source jerk technique using a transient caused by the pulsed neutron source shutdown provides results in good agreement with those obtained from the area-ratio technique. (authors)« less

High-speed multishot pellet injector prototype for the Frascati Tokamak Upgrade

NASA Astrophysics Data System (ADS)

Frattolillo, A.; Migliori, S.; Scaramuzzi, F.; Angelone, G.; Baldarelli, M.; Capobianchi, M.; Cardoni, P.; Domma, C.; Mori, L.; Ronci, G.

1998-07-01

The Frascati Tokamak Upgrade (FTU) may require multiple high-speed pellet injection in order to achieve quasi-steady-state conditions. A research and development program was thus being pursued at ENEA Frascati, aimed at developing a multishot two-stage pellet injector (MPI), featuring eight "pipe gun" barrels and eight small two-stage pneumatic guns. According to FTU requirements, the final goal is to simultaneously produce up to eight D2 pellets, and then deliver them during a plasma pulse (1 s) with any time schedule, at speeds in the 1-2.5 km/s range. A prototype was constructed and tested to demonstrate the feasibility of the concept, and optimize pellet formation and firing sequences. This laboratory facility was automatically operated by means of a programmable logic controller (PLC), and had a full eight-shot capability. However, it was equipped as a first approach with only four two-stage guns. In this article we will describe in detail the guidelines of the MPI prototype design, which were strongly influenced by some external constraints. We will also report on the results of the experimental campaign, during which the feasibility of such a two-stage MPI was demonstrated. Sequences of four intact D2 pellets in the 1.2-1.6 mm size range, fired at time intervals of a few tens up to a few hundreds of ms, were routinely delivered in a laboratory experiment at injection speeds above 2.5 km/s, with good reproducibility and satisfactory aiming dispersion. Some preliminary effort to address the problem of propellant gas handling, based on an innovative approach, gave encouraging results, and work is in progress to carry out an experiment to definitely test the feasibility of this concept.

Comparison between Theoretical Calculation and Experimental Results of Excitation Functions for Production of Relevant Biomedical Radionuclides

NASA Astrophysics Data System (ADS)

Menapace, E.; Birattari, C.; Bonardi, M. L.; Groppi, F.; Morzenti, S.; Zona, C.

2005-05-01

The radionuclide production for biomedical applications has been brought up in the years, as a special nuclear application, at INFN LASA Laboratory, particularly in co-operation with the JRC-Ispra of EC. Mainly scientific aspects concerning radiation detection and the relevant instruments, the measurements of excitation functions of the involved nuclear reactions, the requested radiochemistry studies and further applications have been investigated. On the side of the nuclear data evaluations, based on nuclear model calculations and critically selected experimental data, the appropriate competence has been developed at ENEA Division for Advanced Physics Technologies. A series of high specific activity accelerator-produced radionuclides in no-carrier-added (NCA) form, for uses in metabolic radiotherapy and for PET radiodiagnostics, are investigated. In this work, last revised measurements and model calculations are reviewed for excitation functions of natZn(d,X)64Cu, 66Ga reactions, referring to irradiation experiments at K=38 variable energy Cyclotron of JRC-Ispra. Concerning the reaction data for producing 186gRe and 211At/211gPo (including significant emission spectra) and 210At, most recent and critically selected experimental results are considered and discussed in comparison with model calculations paying special care to pre-equilibrium effects estimate and to the appropriate overall parameterization. Model calculations are presented for 226Ra(p,2n)225Ac reaction, according to the working program of the ongoing IAEA CRP on the matter.

Color (RGB) imaging laser radar

NASA Astrophysics Data System (ADS)

Ferri De Collibus, M.; Bartolini, L.; Fornetti, G.; Francucci, M.; Guarneri, M.; Nuvoli, M.; Paglia, E.; Ricci, R.

2008-03-01

We present a new color (RGB) imaging 3D laser scanner prototype recently developed in ENEA, Italy). The sensor is based on AM range finding technique and uses three distinct beams (650nm, 532nm and 450nm respectively) in monostatic configuration. During a scan the laser beams are simultaneously swept over the target, yielding range and three separated channels (R, G and B) of reflectance information for each sampled point. This information, organized in range and reflectance images, is then elaborated to produce very high definition color pictures and faithful, natively colored 3D models. Notable characteristics of the system are the absence of shadows in the acquired reflectance images - due to the system's monostatic setup and intrinsic self-illumination capability - and high noise rejection, achieved by using a narrow field of view and interferential filters. The system is also very accurate in range determination (accuracy better than 10 -4) at distances up to several meters. These unprecedented features make the system particularly suited to applications in the domain of cultural heritage preservation, where it could be used by conservators for examining in detail the status of degradation of frescoed walls, monuments and paintings, even at several meters of distance and in hardly accessible locations. After providing some theoretical background, we describe the general architecture and operation modes of the color 3D laser scanner, by reporting and discussing first experimental results and comparing high-definition color images produced by the instrument with photographs of the same subjects taken with a Nikon D70 digital camera.

Laser diagnostic technology for early detection of pathogen infestation in orange fruits

NASA Astrophysics Data System (ADS)

Giubileo, Gianfranco; Lai, Antonella; Piccinelli, Delinda; Puiu, Adriana

2010-11-01

Due to an increased expectation of food products that respect high quality and safety standards, there is a need for the growth of accurate, fast, objective and non-destructive technologies for quality determination of food and agricultural products. For this purpose, a diagnostic system based on laser photoacoustic spectroscopy (LPAS) was developed at ENEA Frascati Molecular Spectroscopy Laboratory (Italy). In the design of the photoacoustic detector, particular emphasis was placed in attaining a high sensitivity in detecting ethylene (ET) down to sub-parts per billion level (minimum detectable concentration 0.2 ppb). This was required due to the necessity to monitor and follow up ET production at a single fruit scale. ET is normally synthesised in very low amounts by healthy citrus fruits; however stress conditions such as pathogen attack may induce a substantial increase in the synthesised ET. In the present paper, the comparison between the ET emitted by healthy oranges ( Citrus sinensis L. Osbeck) cv Navel and by Phytophthora citrophthora infested Navel orange fruits are reported. The obtained results show a well evident increase in ET emission from the infested fruit with respect to the healthy one, even 24 h after the inoculation with the pathogen; at that time the tissue necrosis was not yet visible, and the fruit was also not yet damaged. The possibility to perform a real time non-destructive detection of ET traces makes the LPAS a powerful tool for monitoring the healthy state of the citrus fruits.

Comparison between Theoretical Calculation and Experimental Results of Excitation Functions for Production of Relevant Biomedical Radionuclides

DOE Office of Scientific and Technical Information (OSTI.GOV)

Menapace, E.; Birattari, C.; Bonardi, M.L.

The radionuclide production for biomedical applications has been brought up in the years, as a special nuclear application, at INFN LASA Laboratory, particularly in co-operation with the JRC-Ispra of EC. Mainly scientific aspects concerning radiation detection and the relevant instruments, the measurements of excitation functions of the involved nuclear reactions, the requested radiochemistry studies and further applications have been investigated. On the side of the nuclear data evaluations, based on nuclear model calculations and critically selected experimental data, the appropriate competence has been developed at ENEA Division for Advanced Physics Technologies. A series of high specific activity accelerator-produced radionuclides inmore » no-carrier-added (NCA) form, for uses in metabolic radiotherapy and for PET radiodiagnostics, are investigated. In this work, last revised measurements and model calculations are reviewed for excitation functions of natZn(d,X)64Cu, 66Ga reactions, referring to irradiation experiments at K=38 variable energy Cyclotron of JRC-Ispra. Concerning the reaction data for producing 186gRe and 211At/211gPo (including significant emission spectra) and 210At, most recent and critically selected experimental results are considered and discussed in comparison with model calculations paying special care to pre-equilibrium effects estimate and to the appropriate overall parameterization. Model calculations are presented for 226Ra(p,2n)225Ac reaction, according to the working program of the ongoing IAEA CRP on the matter.« less

Conference Report on the 4rd International Symposium on Lithium Applications

NASA Astrophysics Data System (ADS)

Tabares, F. L.; Hirooka, Y.; Maingi, R.; Mazzitelli, G.; Mirnov, V.; Nygren, R.; Ono, M.; Ruzic, D. N.

2016-12-01

The fourth International Symposium on Liquid Metal Application for Fusion Devices (ISLA-2015) was held on 28-30 September 2015 at Granada, Spain, with growing participation and interest from the community working on general aspects of liquid metal research for fusion energy development. The ISLA symposia remain the largest, and arguably, the most important meetings dedicated to liquid metal application for the magnetic fusion research. Overall, 43 presentations plus 7 posters were given, representing 28 institutions from 12 countries. The latest experimental results from 9 magnetic fusion devices were given in 17 presentations from NSTX and LTX (PPPL, USA), FTU (ENEA, Italy), T-11M (Trinity, RF), T-10 (Kurchatov Institute, RF), TJ-II (CIEMAT, Spain), EAST (ASIPP, China), HT-7 (ASIPP, China), DIII-D (GA, USA), ISTTOK (IPFN, Portugal) and KTM (NNC RK, Kazakhstan). Sessions were devoted to the following: (I) liquid metals (LM) in magnetic confinement experiments (facility overviews), (II) LM in magnetic confinement experiments (topical issues), (III) laboratory experiments, (IV) LM tests in linear plasma devices, (V) LM theory/modeling (VI) LM technology and (VII) a special session on lithium-safety and lithium handling. There were contributions from fusion technology communities including IFMIF and TBM, which provided productive exchanges with physics-oriented magnetic confinement liquid metal research groups. This international workshop will continue on a biennial basis (alternating with the Plasma-Surface Interactions (PSI) Conference), with the next workshop scheduled for Moscow, Russian Federation, in 2017.

A preliminary user-friendly, digital console for the control room parameters supervision in old-generation Nuclear Plants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Memmi, F.; Falconi, L.; Cappelli, M.

2012-07-01

Improvements in the awareness of a system status is an essential requirement to achieve safety in every kind of plant. In particular, in the case of Nuclear Power Plants (NPPs), a progress is crucial to enhance the Human Machine Interface (HMI) in order to optimize monitoring and analyzing processes of NPP operational states. Firstly, as old-fashioned plants are concerned, an upgrading of the whole console instrumentation is desirable in order to replace an analog visualization with a full-digital system. In this work, we present a novel instrument able to interface the control console of a nuclear reactor, developed by usingmore » CompactRio, a National Instruments embedded architecture and its dedicated programming language. This real-time industrial controller composed by a real-time processor and FPGA modules has been programmed to visualize the parameters coming from the reactor, and to storage and reproduce significant conditions anytime. This choice has been made on the basis of the FPGA properties: high reliability, determinism, true parallelism and re-configurability, achieved by a simple programming method, based on LabVIEW real-time environment. The system architecture exploits the FPGA capabilities of implementing custom timing and triggering, hardware-based analysis and co-processing, and highest performance control algorithms. Data stored during the supervisory phase can be reproduced by loading data from a measurement file, re-enacting worthwhile operations or conditions. The system has been thought to be used in three different modes, namely Log File Mode, Supervisory Mode and Simulation Mode. The proposed system can be considered as a first step to develop a more complete Decision Support System (DSS): indeed this work is part of a wider project that includes the elaboration of intelligent agents and meta-theory approaches. A synoptic has been created to monitor every kind of action on the plant through an intuitive sight. Furthermore, another important aim of this work is the possibility to have a front panel available on a web interface: CompactRio acts as a remote server and it is accessible on a dedicated LAN. This supervisory system has been tested and validated on the basis of the real control console for the 1-MW TRIGA reactor RC-1 at the ENEA, Casaccia Research Center. In this paper we show some results obtained by recording each variable as the reactor reaches its maximum level of power. The choice of a research reactor for testing the developed system relies on its training and didactic importance for the education of plant operators: in this context a digital instrument can offer a better user-friendly tool for learning and training. It is worthwhile to remark that such a system does not interfere with the console instrumentation, the latter continuing to preserve the total control. (authors)« less

Climate Data Service in the FP7 EarthServer Project

NASA Astrophysics Data System (ADS)

Mantovani, Simone; Natali, Stefano; Barboni, Damiano; Grazia Veratelli, Maria

2013-04-01

EarthServer is a European Framework Program project that aims at developing and demonstrating the usability of open standards (OGC and W3C) in the management of multi-source, any-size, multi-dimensional spatio-temporal data - in short: "Big Earth Data Analytics". In order to demonstrate the feasibility of the approach, six thematic Lighthouse Applications (Cryospheric Science, Airborne Science, Atmospheric/ Climate Science, Geology, Oceanography, and Planetary Science), each with 100+ TB, are implemented. Scope of the Atmospheric/Climate lighthouse application (Climate Data Service) is to implement the system containing global to regional 2D / 3D / 4D datasets retrieved either from satellite observations, from numerical modelling and in-situ observations. Data contained in the Climate Data Service regard atmospheric profiles of temperature / humidity, aerosol content, AOT, and cloud properties provided by entities such as the European Centre for Mesoscale Weather Forecast (ECMWF), the Austrian Meteorological Service (Zentralanstalt für Meteorologie und Geodynamik - ZAMG), the Italian National Agency for new technologies, energies and sustainable development (ENEA), and the Sweden's Meteorological and Hydrological Institute (Sveriges Meteorologiska och Hydrologiska Institut -- SMHI). The system, through an easy-to-use web application permits to browse the loaded data, visualize their temporal evolution on a specific point with the creation of 2D graphs of a single field, or compare different fields on the same point (e.g. temperatures from different models and satellite observations), and visualize maps of specific fields superimposed with high resolution background maps. All data access operations and display are performed by means of OGC standard operations namely WMS, WCS and WCPS. The EarthServer project has just started its second year over a 3-years development plan: the present status the system contains subsets of the final database, with the scope of demonstrating I/O modules and visualization tools. At the end of the project all datasets will be available to the users.

Feasibility of BNCT radiobiological experiments at the HYTHOR facility

NASA Astrophysics Data System (ADS)

Esposito, J.; Ceballos, C.; Soncin, M.; Fabris, C.; Friso, E.; Moro, D.; Colautti, P.; Jori, G.; Rosi, G.; Nava, E.

2008-06-01

HYTHOR (HYbrid Thermal spectrum sHifter tapirO Reactor) is a new thermal-neutron irradiation facility, which was installed and became operative in mid 2005 at the TAPIRO (TAratura PIla Rapida potenza 0) fast reactor, in the Casaccia research centre (near Rome) of ENEA (Ente per le Nuove tecnologie Energia ed Ambiente). The facility has been designed for in vivo radiobiological studies. In HYTHOR irradiation cavity, 1-6 mice can be simultaneously irradiated to study skin melanoma treatments with the BNCT (boron neutron capture therapy). The therapeutic effects of HYTHOR radiation field on mouse melanoma has been studied as a preliminary investigation before studying the tumour local control due to boron neutron capture effect after boronated molecule injection. The method to properly irradiate small animals has been precisely defined. Results show that HYTHOR radiation field is by itself effective in reducing the tumour-growth rate. This finding has to be taken into account in studying the effectiveness of new 10B carriers. A method to properly measure the reduction of the tumour-growth rate is reported and discussed.

Higher-order harmonics coupling in different free-electron laser codes

NASA Astrophysics Data System (ADS)

Giannessi, L.; Freund, H. P.; Musumeci, P.; Reiche, S.

2008-08-01

The capability for simulation of the dynamics of a free-electron laser including the higher-order harmonics in linear undulators exists in several existing codes as MEDUSA [H.P. Freund, S.G. Biedron, and S.V. Milton, IEEE J. Quantum Electron. 27 (2000) 243; H.P. Freund, Phys. Rev. ST-AB 8 (2005) 110701] and PERSEO [L. Giannessi, Overview of Perseo, a system for simulating FEL dynamics in Mathcad, < http://www.jacow.org>, in: Proceedings of FEL 2006 Conference, BESSY, Berlin, Germany, 2006, p. 91], and has been recently implemented in GENESIS 1.3 [See < http://www.perseo.enea.it>]. MEDUSA and GENESIS also include the dynamics of even harmonics induced by the coupling through the betatron motion. In addition MEDUSA, which is based on a non-wiggler averaged model, is capable of simulating the generation of even harmonics in the transversally cold beam regime, i.e. when the even harmonic coupling arises from non-linear effects associated with longitudinal particle dynamics and not to a finite beam emittance. In this paper a comparison between the predictions of the codes in different conditions is given.

Validation of the BUGJEFF311.BOLIB, BUGENDF70.BOLIB and BUGLE-B7 broad-group libraries on the PCA-Replica (H2O/Fe) neutron shielding benchmark experiment

NASA Astrophysics Data System (ADS)

Pescarini, Massimo; Orsi, Roberto; Frisoni, Manuela

2016-03-01

The PCA-Replica 12/13 (H2O/Fe) neutron shielding benchmark experiment was analysed using the TORT-3.2 3D SN code. PCA-Replica reproduces a PWR ex-core radial geometry with alternate layers of water and steel including a pressure vessel simulator. Three broad-group coupled neutron/photon working cross section libraries in FIDO-ANISN format with the same energy group structure (47 n + 20 γ) and based on different nuclear data were alternatively used: the ENEA BUGJEFF311.BOLIB (JEFF-3.1.1) and UGENDF70.BOLIB (ENDF/B-VII.0) libraries and the ORNL BUGLE-B7 (ENDF/B-VII.0) library. Dosimeter cross sections derived from the IAEA IRDF-2002 dosimetry file were employed. The calculated reaction rates for the Rh-103(n,n')Rh-103m, In-115(n,n')In-115m and S-32(n,p)P-32 threshold activation dosimeters and the calculated neutron spectra are compared with the corresponding experimental results.

In vivo skin leptin modulation after 14 MeV neutron irradiation: a molecular and FT-IR spectroscopic study.

PubMed

Cestelli Guidi, M; Mirri, C; Fratini, E; Licursi, V; Negri, R; Marcelli, A; Amendola, R

2012-09-01

This paper discusses gene expression changes in the skin of mice treated by monoenergetic 14 MeV neutron irradiation and the possibility of monitoring the resultant lipid depletion (cross-validated by functional genomic analysis) as a marker of radiation exposure by high-resolution FT-IR (Fourier transform infrared) imaging spectroscopy. The irradiation was performed at the ENEA Frascati Neutron Generator (FNG), which is specifically dedicated to biological samples. FNG is a linear electrostatic accelerator that produces up to 1.0 × 10(11) 14-MeV neutrons per second via the D-T nuclear reaction. The functional genomic approach was applied to four animals for each experimental condition (unirradiated, 0.2 Gy irradiation, or 1 Gy irradiation) 6 hours or 24 hours after exposure. Coregulation of a subclass of keratin and keratin-associated protein genes that are physically clustered in the mouse genome and functionally related to skin and hair follicle proliferation and differentiation was observed. Most of these genes are transiently upregulated at 6 h after the delivery of the lower dose delivered, and drastically downregulated at 24 h after the delivery of the dose of 1 Gy. In contrast, the gene coding for the leptin protein was consistently upregulated upon irradiation with both doses. Leptin is a key protein that regulates lipid accumulation in tissues, and its absence provokes obesity. The tissue analysis was performed by monitoring the accumulation and the distribution of skin lipids using FT-IR imaging spectroscopy. The overall picture indicates the differential modulation of key genes during epidermis homeostasis that leads to the activation of a self-renewal process at low doses of irradiation.

Calibration of GafChromic EBT3 for absorbed dose measurements in 5 MeV proton beam and (60)Co γ-rays.

PubMed

Vadrucci, M; Esposito, G; Ronsivalle, C; Cherubini, R; Marracino, F; Montereali, R M; Picardi, L; Piccinini, M; Pimpinella, M; Vincenti, M A; De Angelis, C

2015-08-01

To study EBT3 GafChromic film in low-energy protons, and for comparison purposes, in a reference (60)Co beam in order to use it as a calibrated dosimetry system in the proton irradiation facility under construction within the framework of the Oncological Therapy with Protons (TOP)-Intensity Modulated Proton Linear Accelerator for RadioTherapy (IMPLART) Project at ENEA-Frascati, Italy. EBT3 film samples were irradiated at the Istituto Nazionale di Fisica Nucleare-Laboratori Nazionali di Legnaro, Italy, with a 5 MeV proton beam generated by a 7 MV Van de Graaff CN accelerator. The nominal dose rates used were 2.1 Gy/min and 40 Gy/min. The delivered dose was determined by measuring the particle fluence and the energy spectrum in air with silicon surface barrier detector monitors. A preliminary study of the EBT3 film beam quality dependence in low-energy protons was conducted by passively degrading the beam energy. EBT3 films were also irradiated at ENEA-National Institute of Ionizing Radiation Metrology with gamma radiation produced by a (60)Co source characterized by an absorbed dose to water rate of 0.26 Gy/min as measured by a calibrated Farmer type ionization chamber. EBT3 film calibration curves were determined by means of a set of 40 film pieces irradiated to various doses ranging from 0.5 Gy to 30 Gy absorbed dose to water. An EPSON Expression 11000XL color scanner in transmission mode was used for film analysis. Scanner response stability, intrafilm uniformity, and interfilm reproducibility were verified. Optical absorption spectra measurements were performed on unirradiated and irradiated EBT3 films to choose the most sensitive color channel to the dose range used. EBT3 GafChromic films show an under response up to about 33% for low-energy protons with respect to (60)Co gamma radiation, which is consistent with the linear energy transfer dependence already observed with higher energy protons, and a negligible dose-rate dependence in the 2-40 Gy/min range. Short- and long-term scanner stabilities were 0.5% and 1.5%, respectively; film uniformity and reproducibility were better than 0.5%. The main purpose of this study was to implement EBT3 dosimetry in the proton low-energy radiobiology line of the TOP-IMPLART accelerator, having a maximum energy of 7 MeV. Low-energy proton and (60)Co calibrated sources were used to investigate the behavior of film response vs to be written in italicum dose. The calibration in 5 MeV protons is currently used for dose assessment in the radiobiological experiments at the TOP-IMPLART accelerator carried out at that energy value.

Conventional and modified Schwarzschild objective for EUV lithography: design relations

NASA Astrophysics Data System (ADS)

Bollanti, S.; di Lazzaro, P.; Flora, F.; Mezi, L.; Murra, D.; Torre, A.

2006-12-01

The design criteria of a Schwarzschild-type optical system are reviewed in relation to its use as an imaging system in an extreme ultraviolet lithography setup. Both the conventional and the modified reductor imaging configurations are considered, and the respective performances, as far as the geometrical resolution in the image plane is concerned, are compared. In this connection, a formal relation defining the modified configuration is elaborated, refining a rather naïve definition presented in an earlier work. The dependence of the geometrical resolution on the image-space numerical aperture for a given magnification is investigated in detail for both configurations. So, the advantages of the modified configuration with respect to the conventional one are clearly evidenced. The results of a semi-analytical procedure are compared with those obtained from a numerical simulation performed by an optical design program. The Schwarzschild objective based system under implementation at the ENEA Frascati Center within the context of the Italian FIRB project for EUV lithography has been used as a model. Best-fit functions accounting for the behaviour of the system parameters vs. the numerical aperture are reported; they can be a useful guide for the design of Schwarzschild objective type optical systems.

Fission neutron source in Rome

NASA Astrophysics Data System (ADS)

Coppola, Mario; Di Majo, V.; Ingrao, G.; Rebessi, S.; Testa, A.

1997-02-01

A fission neutron source is operating in Rome at the ENEA Casaccia Research Center since 1971, consisting of a low power fast reactor named RSV-Tapiro. it is employed for a variety of experiments, including dosimetry, material testing, radiation protection and biology. In particular, application to experimental radiobiology includes studies of the biological action of neutrons in the whole-body irradiated animal, or in specialized systems in vivo or in vitro. For his purpose a vertical irradiation facility was originally constructed. Recently, a new horizontal irradiation facility has been designed to allow the exposure of larger samples or larger sample batches at one time. Dosimetry at the sample irradiation positions is routinely carried out by the conventional method of using two ion chambers. This physical dosimetry has recently been compared with the results of biological dosimetry based on the detection of chromosomal aberrations in peripheral blood human lymphocytes irradiated in vitro. A characterization of the radiation quality in the two configurations has been carried out by tissue equivalent proportional counter microdosimetry measurements. Information about the main characteristics of the reactor and the two irradiation facilities is provided and relevant results of the various measurements are summarized. Radiobiological results obtained using this neutron source are also briefly outlined.

Measurement of organic and elemental carbon in downtown Rome and background area: physical behavior and chemical speciation.

PubMed

Avino, Pasquale; Manigrasso, Maurizio; Rosada, Alberto; Dodaro, Alessandro

2015-02-01

A significant portion of the particulate matter is the total carbonaceous fraction (or total carbon, TC), composed of two main fractions, elemental carbon (EC) and organic carbon (OC), which shows a large variety of organic compounds, e.g. aliphatic, aromatic compounds, alcohols, acids, etc. In this paper, TC, EC and OC concentrations determined in a downtown Rome urban area are discussed considering the influence of meteorological conditions on the temporal-spatial aerosol distribution. Similar measurements were performed at ENEA Casaccia, an area outside Rome, which is considered as the ome background. Since 2000, TC, EC and OC measurements have been performed by means of an Ambient Carbon Particulate Monitor equipped with a NDIR detector. The EC and OC concentrations trends are compared with benzene and CO trends, which are specific indicators of autovehicular traffic, for identifying the primary EC and OC contributions and the secondary OC fraction origin. Further, a chemical investigation is reported for investigating how the main organic (i.e., n-alkanes, n-alkanoic acids, polyaromatic hydrocarbons and nitro-polyaromatic hydrocarbons) and inorganic (i.e., metals, ions) fractions vary their levels during the investigated period in relationship to new regulations and/or technological innovations.

Qualitative thermal characterization and cooling of lithium batteries for electric vehicles

NASA Astrophysics Data System (ADS)

Mariani, A.; D'Annibale, F.; Boccardi, G.; Celata, G. P.; Menale, C.; Bubbico, R.; Vellucci, F.

2014-04-01

The paper deals with the cooling of batteries. The first step was the thermal characterization of a single cell of the module, which consists in the detection of the thermal field by means of thermographic tests during electric charging and discharging. The purpose was to identify possible critical hot points and to evaluate the cooling demand during the normal operation of an electric car. After that, a study on the optimal configuration to obtain the flattening of the temperature profile and to avoid hot points was executed. An experimental plant for cooling capacity evaluation of the batteries, using air as cooling fluid, was realized in our laboratory in ENEA Casaccia. The plant is designed to allow testing at different flow rate and temperatures of the cooling air, useful for the assessment of operative thermal limits in different working conditions. Another experimental facility was built to evaluate the thermal behaviour changes with water as cooling fluid. Experimental tests were carried out on the LiFePO4 batteries, under different electric working conditions using the two loops. In the future, different type of batteries will be tested and the influence of various parameters on the heat transfer will be assessed for possible optimal operative solutions.

Proceedings of the seminar on Leak-Before-Break: Progress in regulatory policies and supporting research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kashima, K.; Wilkowski, G.M.

1988-03-01

The third in a series of international Leak-Before-Break (LBB) Seminars supported in part by the US Nuclear Regulatory Commission was held at TEPCO Hall in the Tokyo Electric Power Company's (TEPCO) Electric Power Museum on May 14 and 15, 1987. The seminar updated the international policies and supporting research on LBB. Attendees included representatives from regulatory agencies, electric utility representatives, fabricators of nuclear power plants, research organizations, and university professors. Regulatory policy was the subject of presentations by Mr. G. Arlotto (US NRC, USA), Dr. H. Schultz (GRS, W. Germany), Dr. P. Milella (ENEA-DISP, Italy), Dr. C. Faidy, P. Jamet,more » and S. Bhandari (EDF/Septen, CEA/CEN, and Framatome, France), and Mr. T. Fukuzawa (MITI, Japan). Dr. F. Nilsson presented revised nondestructive inspection requirements relative to LBB in Sweden. In addition, several papers on the supporting research programs discussed regulatory policy. Questions following the presentations of the papers focused on the impact of various LBB policies or the impact of research findings. Supporting research programs were reviewed on the first and second day by several participants from the US, Japan, Germany, Canada, Italy, Sweden, England, and France.« less

Plasma Chamber and First Wall of the Ignitor Experiment^*

NASA Astrophysics Data System (ADS)

Cucchiaro, A.; Coppi, B.; Bianchi, A.; Lucca, F.

2005-10-01

The new designs of the Plasma Chamber (PC) and of the First Wall (FW) system are based on updated scenarios for vertical plasma disruption (VDE) as well as estimates for the maximum thermal wall loadings at ignition. The PC wall thickness has been optimized to reduce the deformation during the worst disruption event without sacrificing the dimensions of the plasma column. A non linear dynamic analysis of the PC has been performed on a 360^o model of it, taking into account possible toroidal asymmetries of the halo current. Radial EM loads obtained by scaling JET measurements have been also considered. The low-cycle fatigue analysis confirms that the PC is able to meet a lifetime of few thousand cycles for the most extreme combinations of magnetic fields and plasma currents. The FW, made of Molybdenum (TZM) tiles covering the entire inner surface of the PC, has been designed to withstand thermal and EM loads, both under normal operating conditions and in case of disruption. Detailed elasto-plastic structural analyses of the most (EM) loaded tile-carriers show that these are compatible with the adopted fabrication requirements. ^*Sponsored in part by ENEA of Italy and by the U.S. DOE.

AN ALTERNATIVE CALIBRATION OF CR-39 DETECTORS FOR RADON DETECTION BEYOND THE SATURATION LIMIT.

PubMed

Franci, Daniele; Aureli, Tommaso; Cardellini, Francesco

2016-12-01

Time-integrated measurements of indoor radon levels are commonly carried out using solid-state nuclear track detectors (SSNTDs), due to the numerous advantages offered by this radiation detection technique. However, the use of SSNTD also presents some problems that may affect the accuracy of the results. The effect of overlapping tracks often results in the underestimation of the detected track density, which leads to the reduction of the counting efficiency for increasing radon exposure. This article aims to address the effect of overlapping tracks by proposing an alternative calibration technique based on the measurement of the fraction of the detector surface covered by alpha tracks. The method has been tested against a set of Monte Carlo data and then applied to a set of experimental data collected at the radon chamber of the Istituto Nazionale di Metrologia delle Radiazioni Ionizzanti, at the ENEA centre in Casaccia, using CR-39 detectors. It has been proved that the method allows to extend the detectable range of radon exposure far beyond the intrinsic limit imposed by the standard calibration based on the track density. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

High efficiency focus neutron generator

NASA Astrophysics Data System (ADS)

Sadeghi, H.; Amrollahi, R.; Zare, M.; Fazelpour, S.

2017-12-01

In the present paper, the new idea to increase the neutron yield of plasma focus devices is investigated and the results are presented. Based on many studies, more than 90% of neutrons in plasma focus devices were produced by beam target interactions and only 10% of them were due to thermonuclear reactions. While propounding the new idea, the number of collisions between deuteron ions and deuterium gas atoms were increased remarkably well. The COMSOL Multiphysics 5.2 was used to study the given idea in the known 28 plasma focus devices. In this circumstance, the neutron yield of this system was also obtained and reported. Finally, it was found that in the ENEA device with 1 Hz working frequency, 1.1 × 109 and 1.1 × 1011 neutrons per second were produced by D-D and D-T reactions, respectively. In addition, in the NX2 device with 16 Hz working frequency, 1.34 × 1010 and 1.34 × 1012 neutrons per second were produced by D-D and D-T reactions, respectively. The results show that with regards to the sizes and energy of these devices, they can be used as the efficient neutron generators.

Three-dimensional, time-dependent simulation of free-electron lasers with planar, helical, and elliptical undulators

NASA Astrophysics Data System (ADS)

Freund, H. P.; van der Slot, P. J. M.; Grimminck, D. L. A. G.; Setija, I. D.; Falgari, P.

2017-02-01

Free-electron lasers (FELs) have been built ranging in wavelength from long-wavelength oscillators using partial wave guiding through ultraviolet through hard x-ray that are either seeded or start from noise. In addition, FELs that produce different polarizations of the output radiation ranging from linear through elliptic to circular polarization are currently under study. In this paper, we develop a three-dimensional, time-dependent formulation that is capable of modeling this large variety of FEL configurations including different polarizations. We employ a modal expansion for the optical field, i.e., a Gaussian expansion with variable polarization for free-space propagation. This formulation uses the full Newton-Lorentz force equations to track the particles through the optical and magnetostatic fields. As a result, arbitrary three-dimensional representations for different undulator configurations are implemented, including planar, helical, and elliptical undulators. In particular, we present an analytic model of an APPLE-II undulator to treat arbitrary elliptical polarizations, which is used to treat general elliptical polarizations. To model oscillator configurations, and allow propagation of the optical field outside the undulator and interact with optical elements, we link the FEL simulation with the optical propagation code OPC. We present simulations using the APPLE-II undulator model to produce elliptically polarized output radiation, and present a detailed comparison with recent experiments using a tapered undulator configuration at the Linac Coherent Light Source. Validation of the nonlinear formation is also shown by comparison with experimental results obtained in the Sorgente Pulsata Auto-amplificata di Radiazione Coerente SASE FEL experiment at ENEA Frascati, a seeded tapered amplifier experiment at Brookhaven National Laboratory, and the 10 kW upgrade oscillator experiment at the Thomas Jefferson National Accelerator Facility.

[Pre-hospital adverse events: a way to go].

PubMed

Alvarez-Ortiz, Nancy Jezzi; Aranaz Andrés, Jesús María; Gea Velázquez De Castro, María Teresa; Miralles Bueno, Juan José

2010-01-01

The occurrence of adverse events is a problem at all levels of care and creates a significant burden of morbidity and mortality. In Spain there have been significant investigations of adverse effects (AE) in hospitals and primary care, however, studies of pre-hospital care are not yet developed. The aim of this study was to determine the frequency, type, preventability, severity and impact of "pre-hospital" adverse events, which were detected in the hospitalization index and the comparing those that occurred in ambulatory and non-ambulatory care. Case Series Study, with analytical components, of a sample of subjects included in the "National study of adverse events related to hospitalization (ENEAS). Qualitative data are presented as proportions with confidence intervals. For comparative analysis of qualitative data, we used the chi-square test. Of a total of 5624 patients, 2.3% (N=131) ((95%)CI: 1.94-2.72) had an AE that occurred prior to hospitalization or "pre-hospital", and 40.5% of these (N=53) ((95%)CI: 32.05-48.86) were preventable. In 44 patients the AE had its origin in ambulatory care and 85 patients in non-ambulatory care. The characteristic of patients with ambulatory AE are men and older women (median 76 years) who consulted for medical problems (84.1%) and the AE were related to medication in 77.8%. The characteristic of patients with non-ambulatory AE, were men (median 73 years), consulting for medical and surgical problems (44,7-55,3%) and the EA is related to medications, infections and procedures. The characteristics of patients with AE and undesirable effects that occurred during pre-hospitalization period depended on whether they originated during ambulatory care or non-ambulatory care. Therefore prevention strategies should take these differences into account. Copyright 2009 SECA. Published by Elsevier Espana. All rights reserved.

Using a new incentive mechanism to improve wastewater sector performance: the case study of Italy.

PubMed

De Gisi, Sabino; Petta, Luigi; Farina, Roberto; De Feo, Giovanni

2014-01-01

The system of "Service Objectives", introduced by the Italian National Strategic Framework 2007-2013, is an innovative results-oriented programme concerning 4 thematic areas (education, care for the elderly and children, management of municipal solid wastes and integrated water service) in which the Ministry of Economic Development and eight Southern Italy districts are involved. The system was initially associated to an incentive mechanism which provided subsidies for a total amount of EUR 3 billion from the national Underdeveloped Areas Fund, according to the achievement of specific targets set for 11 service indicators in 2013. The indicators used for the integrated water service refer to the efficiency in water supply service as well as the coverage of wastewater treatment service. The aim of the study is to describe the activities carried out in Italy by the ENEA Agency in order to define a new performance indicator for wastewater treatment service taking into account the appropriateness and efficiency of existing plants equipment and, consequently, evaluating economic incentives. The proposed procedure takes into account both wastewater treatment demand and quality of wastewater treatment service offered to citizens. Input data, provided by the National Institute of Statistics (ISTAT), were elaborated in order to define appropriate parameters, with a multi-criteria analysis being used to define the new performance indicator. The applicability of the proposed procedure was verified considering all the 8 Southern Italy and Island districts (Abruzzo, Molise, Campania, Apulia, Basilicata, Calabria, Sicily and Sardinia) involved in the programme. The obtained results show that the quality of municipal wastewater may influence the calculation of the incentive amount. The performance indicators defined in this work might be conveniently extended to other contexts similar to the assessed geographical area (Southern Italy and Islands). Copyright © 2013 Elsevier Ltd. All rights reserved.

Experimental investigation on predictive models for motive flow calculation through ejectors for transcritical CO2 heat pumps

NASA Astrophysics Data System (ADS)

Boccardi, G.; Lillo, G.; Mastrullo, R.; Mauro, A. W.; Saraceno, L.; Pieve, M.; Trinchieri, R.

2017-11-01

Nowadays, air conditioning systems, especially those used in residential and office buildings, contribute largely to the energy consumptions and to the direct and indirect emissions of greenhouse gases. Carbon dioxide (CO2) is an interesting option to replace traditional HFCs in vapor compression systems, due to its environmentally friendly characteristics: zero ODP and extremely low GWP. In the case of heat pumps, the use of ejection systems for the expansion phase can contribute to recovery a fraction of the mechanical energy otherwise dissipated as friction, bringing to significant benefits in terms of performance. Currently, at the laboratory DTE-PCU-SPCT of the research center ENEA (Casaccia) in cooperation with the Industrial Engineering Department of Federico II University of Naples, a project is in progress, in order to evaluate experimentally the effect of several ejectors geometries on the global performance of a CO2 heat pump working with a transcritical cycle. As a part of this project, measurements of the motive flow mass flow rate have been carried out, in transcritical CO2 conditions. The ejector sizing is a crucial point for the balancing of components and the correct operation of the CO2 heat pump and therefore the availability of reliable calculation methods for the motive flowrate would be useful. This paper presents the results obtained by a comparison between the new experimental data and the predictions of some predictive semi-empirical correlations available in the open literature for transcritical CO2 conditions. Their predictions are analyzed as a function of the main physical parameters of the process to assess their reliability compared to the experimental data. Based on these indications and of the available experimental data, a new semi-empirical correlations and a calculation method based on the hypothesis of isentropic and choked two-phase flow are presented.

Active learning innovative for the study of climatic variations in Sicily (Italy) and micro-climates in confined environments. Digitized construction of agro-meteorological laboratory and entrepreneurial development of methodical home automation systems

NASA Astrophysics Data System (ADS)

Crimi, Pietro

2017-04-01

In education to issues of environmental sustainability and the use of renewable energy resources, there are the existing laboratory teaching methodologies in Superior School "A. Volta" in Palermo (Italy) for acquisition, processing and control network of agro-meteorological data on the local area. This station was planned to allow students practical multidisciplinary learning experiences in the field of agro-meteorological applications. The School started a few months ago a project of MIUR (Italian Ministry of Education) that updates the lab through the most innovative digital technologies in the field of mechatronics, domotic and sustainable energy, that are supported by the latest needs of scientific-educational multimedia. It is an educational training that intends to implement a data collection center agro-meteorological on "digital platforms," informational purposes and applications, on current issues of climate changes and their consequences in Sicily (Italy). This active learning will interconnect the data collected from the station weather and climate of the school with those locally and regionally, with "weather-climatic patterns" correlations that are implemented in the Mediterranean area (International Program "GAW-Global Atmosphere Watch"). For this reason were enabled synergies with two major public scientific research and acquisition services-data disclosure (ENEA and SIAS-Agrometeorological Information Service, Sicily Region), both to energy efficiency of the School Station, both to support data and digital applications in GIS, with agro-meteorological services to companies operating in the agricultural and environmental sustainability, high consideration themes in European Programming. A branch of this training course is the entrepreneurship education, carried out by a few years in School with the development of "experimental models" for the creation of "innovation clusters" to make entrepreneurial experience since school, creating/managing mini-companies. In the European educational program (Erasmus + KA3) called "Innovation Cluster for Entrepreneurship Education (ICEE)", aimed at enhancing the students' creativity and entrepreneurship, one of the mini-companies, created by students at the Institute, has developed and produced with innovative software a prototype automated system, a mini-greenhouse powered by solar energy, capable of recreating the habitat suitable for house plants, through the automated control of numerous agricultural micro-climatic parameters. Creating multimedia systems such as web platforms, advanced software and app/QR-code for mobile devices, defines the most innovative tools in computer science outreach phases. This experimental approach incorporates the teaching methods that are defined by the curriculum of the "Liceo delle Scienze Applicate" that exists in the School, with the proposition of experimental models that besides being "learning models" can switch into "knowledge models" correlated with scientific and technical-scientific models that exist in the world of research. La Natura non distrugge, che per creare, e non crea, che per distruggere (Storia dell'Astronomia, 1813 - Giacomo Leopardi)

The accomplishments of lithium target and test facility validation activities in the IFMIF/EVEDA phase

NASA Astrophysics Data System (ADS)

Arbeiter, Frederik; Baluc, Nadine; Favuzza, Paolo; Gröschel, Friedrich; Heidinger, Roland; Ibarra, Angel; Knaster, Juan; Kanemura, Takuji; Kondo, Hiroo; Massaut, Vincent; Saverio Nitti, Francesco; Miccichè, Gioacchino; O'hira, Shigeru; Rapisarda, David; Sugimoto, Masayoshi; Wakai, Eiichi; Yokomine, Takehiko

2018-01-01

As part of the engineering validation and engineering design activities (EVEDA) phase for the international fusion materials irradiation facility IFMIF, major elements of a lithium target facility and the test facility were designed, prototyped and validated. For the lithium target facility, the EVEDA lithium test loop was built at JAEA and used to test the stability (waves and long term) of the lithium flow in the target, work out the startup procedures, and test lithium purification and analysis. It was confirmed by experiments in the Lifus 6 plant at ENEA that lithium corrosion on ferritic martensitic steels is acceptably low. Furthermore, complex remote handling procedures for the remote maintenance of the target in the test cell environment were successfully practiced. For the test facility, two variants of a high flux test module were prototyped and tested in helium loops, demonstrating their good capabilities of maintaining the material specimens at the desired temperature with a low temperature spread. Irradiation tests were performed for heated specimen capsules and irradiation instrumentation in the BR2 reactor at SCK-CEN. The small specimen test technique, essential for obtaining material test results with limited irradiation volume, was advanced by evaluating specimen shape and test technique influences.

Optimal Equilibria and Plasma Parameter Evolutions for the Ignitor Experiment*

NASA Astrophysics Data System (ADS)

Airoldi, A.; Cenacchi, G.; Coppi, B.

2011-10-01

In view of the operation of the Ignitor machine in both the H and the I-regime, optimal equilibrium configurations that can sustain plasma currents Ip up to 10 MA with a double X-point have been identified. In fact, the emergence of the I-regime in double X-point configurations has not been observed experimentally yet. The characteristics of the magnetic equilibrium configurations that can be produced play a crucial role in the performance of the machine. Therefore, particular care has been devoted to the study of plasma equilibria relevant to the main phases of the discharge evolution. A series of simulations to be utilized for the control of the relevant (sub-ignited) plasma parameters has been carried out using the JETTO transport code considering different values of the plasma current and, correspondingly, of the magnetic field. Special attention has been devoted to non-igniting experiments with Ip = 5 MA and BT = 8 T, where BT is the toroidal magnetic field, as they can be performed with much better duty cycles and longer duration than experiments aimed at reaching the most extreme plasma parameters and ignition in particular. The results of the relevant analyses with a discussion of the adopted transport coefficients is presented. * Sponsored in part by ENEA and the U.S. DOE.

Experimental characterization of HOTNES: A new thermal neutron facility with large homogeneity area

NASA Astrophysics Data System (ADS)

Bedogni, R.; Sperduti, A.; Pietropaolo, A.; Pillon, M.; Pola, A.; Gómez-Ros, J. M.

2017-01-01

A new thermal neutron irradiation facility, called HOTNES (HOmogeneous Thermal NEutron Source), was established in the framework of a collaboration between INFN-LNF and ENEA-Frascati. HOTNES is a polyethylene assembly, with about 70 cmx70 cm square section and 100 cm height, including a large, cylindrical cavity with diameter 30 cm and height 70 cm. The facility is supplied by a 241Am-B source located at the bottom of this cavity. The facility was designed in such a way that the iso-thermal-fluence surfaces, characterizing the irradiation volume, coincide with planes parallel to the cavity bottom. The thermal fluence rate across a given isofluence plane is as uniform as 1% on a disk with 30 cm diameter. Thermal fluence rate values from about 700 cm-2 s-1 to 1000 cm-2 s-1 can be achieved. The facility design, previously optimized by Monte Carlo simulation, was experimentally verified. The following techniques were used: gold activation foils to assess the thermal fluence rate, semiconductor-based active detector for mapping the irradiation volume, and Bonner Sphere Spectrometer to determine the complete neutron spectrum. HOTNES is expected to be attractive for the scientific community involved in neutron metrology, neutron dosimetry and neutron detector testing.

Downwelling radiation at the sea surface in the central Mediterranean: one year of shortwave and longwave irradiance measurements on the Lampedusa buoy

NASA Astrophysics Data System (ADS)

di Sarra, Alcide; Bommarito, Carlo; Anello, Fabrizio; Di Iorio, Tatiana; Meloni, Daniela; Monteleone, Francesco; Pace, Giandomenico; Piacentino, Salvatore; Sferlazzo, Damiano

2017-04-01

An oceanographic buoy has been developed and deployed in August 2015 about 3.3 miles South West of the island of Lampedusa, at 35.49°N, 12.47°E, in the central Mediterranean Sea. The buoy was developed within the Italian RITMARE flagship project, and contributes to the Italian fixed-point oceanographic observation network. The buoy is an elastic beacon type and is intended to study air-sea interactions, propagation of radiation underwater, and oceanographic properties. The buoy measurements complement the atmospheric observations carried out at the long-term Station for Climate Observations on the island of Lampedusa (www.lampedusa.enea.it; 35.52°N, 12.63°E), which is located about 15 km E-NE of the buoy. Underwater instruments and part of the atmospheric sensors are presently being installed on the buoy. Measurements of downwelling shortwave, SW, and longwave, LW, irradiance, have been made since September 2015 with a Kipp and Zonen CMP21 pyranometer and a Kipp and Zonen CGR4 pyrgeometer, respectively. The radiometers are mounted on a small platform at about 7 m above sea level, on an arm protruding southward of the buoy. High time resolution data, at 1 Hz, have been acquired since December 2015, together with the sensors' attitude. Data from the period December 2015-December 2016 are analyzed and compared with measurements made on land at the Station for Climate Observations at 50 m above mean sea level. This study aims at deriving high quality determinations of the downwelling radiation over sea in the central Mediterranean. The following aspects will be discussed: - representativeness of time averaging of irradiance measurements over moving platforms; - comparison of downwelling irradiance measurements made over land and over ocean, and identification of possible correction strategies to infer irradiances over the ocean from close by measurements made over land; - influence of dome cleaning on the quality of measurements; - envisaging possible corrections strategies for varying radiometers' attitude.

The relation between air pollution data and planetary boundary layer quantities in a complex coastal industrial site nearby populated areas.

NASA Astrophysics Data System (ADS)

Mammarella, M. C.; Grandoni, G.; Fernando, J.; Cacciani, M.; di Sabatino, S.; Favaron, M.; Fedele, P.

2010-09-01

The connection among boundary layer phenomena, atmospheric pollutant dynamics and human health is an established fact, taking many different forms depending on local characteristics, including slope and position of relief and/or coastline, surface roughness, emission patterns. The problem is especially interesting in complex and coastal terrain, where concurrence of slope and sea induced local circulation interact reciprocally, yielding a complex pattern whose interpretation may go beyond pure modeling, and devise specific measurements among which the planetary boundary layer (PBL) height. An occasion for studying this important theme has been offered by Regione Molise and Valle del Biferno Consortium (COSIB), for the specific case of the industrial complex of Valle del Biferno, 3 km inland of Termoli, in Central Italy, on the Adriatic coast. The local government, sensitive to air quality and public health in the industrial area, together with COSIB has co-financed a research project aimed at gaining knowledge about local meteorology, PBL phenomena and atmospheric pollutant dispersion in the area. Expected results include new air quality monitoring and control methodologies in Valle del Biferno for a sustainable development in an environmentally respectful manner, at a site already characterized by a high environmental and landscape value. The research project, developed by ENEA, has began in 2007 and will conclude in December 2010. Project activities involve research group from Europe, the United States of America, and the Russian Federation. Scientific and practical results will be published and presented in occasion of the final workshop to be held on project conclusion. The scientific interest of Valle del Biferno case stems from the specific local characteristics at site. Given the valley orientation respect to mean synoptic circulation, local effects as sea and slope breezes are dominant, and a complex wind regime develops affecting local transport and diffusion of pollutants emitted in the area of the industrial complex. All effects studied, although influenced by local conditions, characterize not only this industrial area but all areas located along the coastline. This location is highly frequent in Italy and the World, as most industrial complexes in the World occur at coastal sites, where access to harbors and transport networks are facilitated. The Valle del Biferno case may then yield important data to many industrial sites.

ANITA-2000 activation code package - updating of the decay data libraries and validation on the experimental data of the 14 MeV Frascati Neutron Generator

NASA Astrophysics Data System (ADS)

Frisoni, Manuela

2016-03-01

ANITA-2000 is a code package for the activation characterization of materials exposed to neutron irradiation released by ENEA to OECD-NEADB and ORNL-RSICC. The main component of the package is the activation code ANITA-4M that computes the radioactive inventory of a material exposed to neutron irradiation. The code requires the decay data library (file fl1) containing the quantities describing the decay properties of the unstable nuclides and the library (file fl2) containing the gamma ray spectra emitted by the radioactive nuclei. The fl1 and fl2 files of the ANITA-2000 code package, originally based on the evaluated nuclear data library FENDL/D-2.0, were recently updated on the basis of the JEFF-3.1.1 Radioactive Decay Data Library. This paper presents the results of the validation of the new fl1 decay data library through the comparison of the ANITA-4M calculated values with the measured electron and photon decay heats and activities of fusion material samples irradiated at the 14 MeV Frascati Neutron Generator (FNG) of the NEA-Frascati Research Centre. Twelve material samples were considered, namely: Mo, Cu, Hf, Mg, Ni, Cd, Sn, Re, Ti, W, Ag and Al. The ratios between calculated and experimental values (C/E) are shown and discussed in this paper.

NUCLEAR HEATING IN LIF DOSEMETERS IN A FUSION NEUTRON FIELD, TRIAL OF DIRECT COMPARISON OF EXPERIMENTAL AND SIMULATED RESULTS.

PubMed

Pohorecki, Wladyslaw; Obryk, Barbara

2017-09-29

The results of nuclear heating measured by means of thermoluminescent dosemeters (TLD-LiF) in a Cu block irradiated by 14 MeV neutrons are presented. The integral Cu experiment relevant for verification of copper nuclear data at neutron energies characteristic for fusion facilities was performed in the ENEA FNG Laboratory at Frascati. Five types of TLDs were used: highly photon sensitive LiF:Mg,Cu,P (MCP-N), 7LiF:Mg,Cu,P (MCP-7) and standard, lower sensitivity LiF:Mg,Ti (MTS-N), 7LiF:Mg,Ti (MTS-7) and 6LiF:Mg,Ti (MTS-6). Calibration of the detectors was performed with gamma rays in terms of air-kerma (10 mGy of 137Cs air-kerma). Nuclear heating in the Cu block was also calculated with the use of MCNP transport code Nuclear heating in Cu and air in TLD's positions was calculated as well. The nuclear heating contribution from all simulated by MCNP6 code particles including protons, deuterons, alphas tritons and heavier ions produced by the neutron interactions were calculated. A trial of the direct comparison between experimental results and results of simulation was performed. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Update of the BIPM comparison BIPM.RI(II)-K1.Cu-64 of activity measurements of the radionuclide 64Cu to include the 2009 results of the CMI-IIR (Czech Rep.) and the NPL (UK), the 2010 result of the LNE-LNHB (France) and the 2011 result of the ENEA-INMRI (Italy)

NASA Astrophysics Data System (ADS)

Michotte, C.; Ratel, G.; Courte, S.; Sochorovà, J.; Auerbach, P.; Keightley, J.; Johansson, L.; Bakhshandeiar, E.; Cassette, P.; Moune, M.; Capogni, M.; De Felice, P.

2013-01-01

Since 2009, four national metrology institutes (NMI) have submitted four samples of known activity of 64Cu to the International Reference System (SIR) for activity comparison at the Bureau International des Poids et Mesures (BIPM), with comparison identifier BIPM.RI(II)-K1.Cu-64. The values of the activity submitted were between about 3 MBq and 260 MBq. There are now five results in the BIPM.RI(II)-K1.Cu-64 comparison. A key comparison reference value (KCRV) has been calculated for the first time for this nuclide. The degrees of equivalence between each equivalent activity measured in the SIR and the KCRV have been calculated and the results are given in the form of a table. A graphical presentation is also given. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCRI, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

Assessment of ocean models in Mediterranean Sea against altimetry and gravimetry measurements

NASA Astrophysics Data System (ADS)

Fenoglio-Marc, Luciana; Uebbing, Bernd; Kusche, Jürgen

2017-04-01

This work aims at assessing in a regional study in the Mediterranean Sea the agreement between ocean model outputs and satellite altimetry and satellite gravity observations. Satellite sea level change are from altimeter data made available by the Sea Level Climate Change Initiative (SLCCI) and from satellite gravity data made available by GRACE. We consider two ocean simulations not assimilating satellite altimeter data and one ocean model reanalysis assimilating satellite altimetry. Ocean model simulations can provide some insight on the ocean variability, but they are affected by biases due to errors in model formulation, specification of initial states and forcing, and are not directly constrained by observations. Their trend can be quite different from the altimetric observations due to surface radiation biases, however they are physically consistent. Ocean reanalyses are the combination of ocean models, atmospheric forcing fluxes and ocean observations via data assimilation methods and have the potential to provide more accurate information than observation-only or model-only based ocean estimations. They will be closer to altimetry at long and short timescales, but assimilation may destroy mass consistency. We use two ocean simulations which are part of the Med-CORDEX initiative (https://www.medcordex.eu). The first is the CNRM-RCM4 fully-coupled Regional Climate System Model (RCMS) simulation developed at METEOFRANCE for 1980-2012. The second is the PROTHEUS standalone hindcast simulation developed at ENEA and covers the interval 1960-2012. The third model is the regional model MEDSEA_REANALYSIS_PHIS_006_004 assimilating satellite altimeter data (http://marine.copernicus.eu/) and available over 1987-2014. Comparison at basin and regional scale are made. First the steric, thermo-steric, halosteric and dynamic components output of the models are compared. Then the total sea level given by the models is compared to the altimeter observations. Finally the mass component derived from GRACE is compared to the difference between the total sea level and the steric component. We observe large differences between the ocean models and discuss the model which best agrees with the CCI sea level product at short and at longer timescales. We consider departure in sea level trends, inter-annual variability and seasonal cycle. The work is part of the Sea Level Climate Change Initiative project.

Survey Methods for Earthquake Damages in the "CAMERA degli SPOSI" of Mantegna (mantova)

NASA Astrophysics Data System (ADS)

Fratus de Balestrini, E.; Ballarin, M.; Balletti, C.; Buttolo, V.; Gottardi, C.; Guerra, F.; Mander, S.; Pilot, L.; Vernier, P.

2013-07-01

Cultural Heritage constitutes a fundamental resource for all Countries, even in economic terms, as it can be considered an extraordinary tourist attraction. This is particularly true for Italy, which is one of the Countries with the richest artistic heritage in the world. For this reason, restoration becomes an essential step towards the conservation and therefore valorisation of architecture. In this context, this paper focuses on one of the first stages that allow us to reach a complete knowledge of a building. Because of the earthquake of May 2012, the Castle of San Giorgio in Mantova (Italy) presented a series of structural damages. On the occasion of its upcoming re-opening to the public, the Soprintendenza per i Beni Architettonici e Paesaggistici per le province di Brescia, Cremona e Mantova has requested an analysis and evaluation of the damages for the development of an intervention project. In particular, a special attention was given to the "Camera degli Sposi" ("Bridal Chamber"), also known as the Camera picta ("painted chamber"). It is a frescoed room, with illusionistic paintings by Andrea Mantegna, located in the northeast tower of the Castle. It was painted between 1465 and 1474 and commissioned by Ludovico Gonzaga, and it is well-known for the use of trompe l'oeil details and for the decoration of its ceiling. The seismic shakes damaged the wall decorated with the "Scena della Corte" ("Court Scene"), above the chimney, re-opening an old crack that had to be analysed, in order to understand whether the damage was structural or just superficial. The diagnostic analyses constitute a fundamental prerequisite for the elaboration of any kind of intervention or restoration in any architectural, artistic or archaeological framework. To obtain a description of the conservation state of the Camera, non-invasive integrated survey techniques were applied. The purpose of the study presented here is the definition of a methodology able to support the necessity of a rapid restoration. In order to acquire the useful data for the damage evaluation, we used three different kinds of laser scanners. These were chosen according to the dimension of the object that had to be surveyed. The first is Riegl LMS-Z390i, a time of flight laser scanner that was used to survey the external surface of one of the fronts of the Castle. The second one is Faro Focus 3D, a phase-based scanner, used for the indoor survey of the "Camera degli Sposi" and the touristic path from the "Scalone di Enea" to the Camera itself. Finally, a triangulation laser scanner, Konika Minolta Vivid VI-9i, was used to measure the dimension of the crack, for its whole length. All the data acquired by these scanners were georeferenced in the same reference system, defined through a topographic network. The data collected were processed in order to obtain a number of representations, both in two and three dimensions, useful for a complete knowledge of the state of condition of the building. This paper analyses the surveying process in all its different phases: from the planning, to the data collection, and the postelaborations.

Test of FBG sensors for monitoring high pressure pipes

NASA Astrophysics Data System (ADS)

Paolozzi, Antonio; Paris, Claudio; Vendittozzi, Cristian; Felli, Ferdinando; Mongelli, Marialuisa; De Canio, Gerardo; Colucci, Alessandro; Asanuma, Hiroshi

2017-04-01

Fibre Bragg Grating (FBG) sensors are increasingly being used on a wide range of civil, industrial and aerospace structures. The sensors are created inside optical fibres (usually standard telecommunication fibres); the optical fibres technology allows to install the sensors on structures working in harsh environments, since the materials are almost insensitive to corrosion, the monitoring system can be positioned far away from the sensors without sensible signal losses, and there is no risk of electric discharge. FBG sensors can be used to create strain gages, thermometers or accelerometers, depending on the coating on the grating, on the way the grating is fixed to the structure, and on the presence of a specifically designed interface that can act as a transducer. This paper describes a test of several different FBG sensors to monitor an high pressure pipe that feeds the hydraulic actuators of a 6 degrees-of-freedom shaking table at the ENEA Casaccia research centre. A bare FBG sensor and a copper coated FBG sensor have been glued on the pipe. A third sensor has been mounted on a special interface to amplify the vibrations; this last sensor can be placed on the steel pipe by a magnetic mounting system, that also allows the its removal. All the sensor are placed parallel to the axis of the pipe. The analysis of the data recorded when the shaking table is operated will allow to determine which kind of sensor is best suited for structural monitoring of high pressure pipelines.

List of Participants

NASA Astrophysics Data System (ADS)

2014-07-01

Alba Paolo (Università di Torino) Becattini Francesco (Università di Firenze) Bombaci Ignazio (Università di Pisa) Bonaccorso Angela (INFN Pisa) Colonna Maria (INFN-LNS Catania) Coraggio Luigi (INFN Napoli) Covello Aldo (Università di Napoli) Di Toro Massimo (Università di Catania) De Angelis Giacomo (INFN-LNL Legnaro) Gargano Angela (INFN Napoli) Gattobigio Mario (INLN, Université de Nice-Sophia Antipolis, CNRS, France) Gensini Paolo (INFN Lecce) Giannini Mauro (Università di Genova) Girlanda Luca (Università del Salento) Giusti Carlotta (Università di Pavia) Greco Vincenzo (Università di Catania) Grossi Eduardo (Università di Firenze) Itaco Nunzio (Università di Napoli) Kievsky Alejandro (INFN Pisa) Lanza Edoardo (INFN Catania) Lavagno Andrea (Politecnico di Torino) Logoteta Domenico (Universidade de Coimbra, Coimbra, Portugal) Lo Iudice Nicola (Università di Napoli) Lombardo Maria Paola (INFN-LNF Frascati) Lo Meo Sergio (ENEA Bologna) Mannarelli Massimo (INFN-LNGS Assergi) Marcucci Laura Elisa (Università di Pisa) Matera Francesco (Università di Firenze) Orlandini Giuseppina (Università di Trento) Pacati Franco (Università di Pavia) Pederiva Francesco (Università di Trento) Pirrone Sara (INFN Catania) Puglisi Armando (Università di Catania) Radici Marco (INFN Pavia) Rinaldi Matteo (Università di Perugia) Roggero Alessandro (Università di Trento) Rolando Valentina (Università di Ferrara) Rosati Sergio (Università di Pisa) Ruggieri Marco (Università di Catania) Salmè Gianni (INFN Roma) Santopinto Elena (INFN Genova) Scopetta Sergio (Università di Perugia) Taiuti Mauro (Università di Genova) Vigezzi Enrico (INFN Milano) Viviani Michele (INFN Pisa) Vorabbi Matteo (Università di Pavia)

[Pleural mesothelioma mortality in Italy: time series reconstruction (1970-2009) and comparison with incidence (2003-2008)].

PubMed

Ferrante, Pierpaolo; Mastrantonio, Marina; Uccelli, Raffaella; Corfiati, Marisa; Marinaccio, Alessandro

2016-01-01

the large amount of asbestos used in many Countries (including Italy) is causing an epidemic of asbestos related diseases, which is still ongoing because of their long latency. this study is aimed at reconstructing Italian time series of deaths for mesothelioma in the period 1970-2009 and comparing Italian incidence and mortality data. deaths for pleural cancer (1970-2003,2006-2009) and mesothelioma (2003, 2006-2009) were recorded by the Italian Institute of Statistics (Istat) and provided by the Italian National Agency for New Technologies, Energy and the Environment (ENEA), incidence cases (1993-2008) were provided by the Italian mesotheliomas register (ReNaM) at the Italian National Workers' Compensation Authority (Inail). For the period before ICD-10 implementation (1970-2002) and when Istat data (2004-2005) are lacking, mesothelioma deaths were estimated through statistical models (logistic, Poisson). National incidence and mortality data were compared during the overlapping period (2003, 2006-2008). the mortality curve strongly rises from 1970 and seems to be smoothed in the last years. Mortality caused by mesothelioma and incident cases with certain diagnosis are overlapping, as are mortality due to pleural cancer other than mesothelioma and mesothelioma incidence with uncertain diagnosis (probable/possible). this epidemiological analysis of deaths encoded as pleural tumour suggests to carefully investigate space-temporal distribution before excluding they could be mesotheliomas. Some new lights have been thrown on the statistical behaviour of mesothelioma mortality.

GENESI-DR Portal: a scientific gateway to distributed repositories

NASA Astrophysics Data System (ADS)

Goncalves, Pedro; Brito, Fabrice; D'Andria, Fabio; Cossu, Roberto; Fusco, Luigi

2010-05-01

GENESI-DR (Ground European Network for Earth Science Interoperations - Digital Repositories) is a European Commission (EC)-funded project, kicked-off early 2008 lead by ESA; partners include Space Agencies (DLR, ASI, CNES), both space and no-space data providers such as ENEA (I), Infoterra (UK), K-SAT (N), NILU (N), JRC (EU) and industry as Elsag Datamat (I), CS (F) and TERRADUE (I). GENESI-DR intends to meet the challenge of facilitating "time to science" from different Earth Science disciplines in discovery, access and use (combining, integrating, processing, …) of historical and recent Earth-related data from space, airborne and in-situ sensors, which are archived in large distributed repositories. "Discovering" which data are available on a "geospatial web" is one of the main challenges ES scientists have to face today. Some well- known data sets are referred to in many places, available from many sources. For core information with a common purpose many copies are distributed, e.g., VMap0, Landsat, and SRTM. Other data sets in low or local demand may only be found in a few places and niche communities. Relevant services, results of analysis, applications and tools are accessible in a very scattered and uncoordinated way, often through individual initiatives from Earth Observation mission operators, scientific institutes dealing with ground measurements, service companies or data catalogues. In the discourse of Spatial Data Infrastructures, there are "catalogue services" - directories containing information on where spatial data and services can be found. For metadata "records" describing spatial data and services, there are "registries". The Geospatial industry coins specifications for search interfaces, where it might do better to reach out to other information retrieval and Internet communities. These considerations are the basis for the GENESI-DR scientific portal, which adopts a simple model allowing the geo-spatial classification and discovery of information as a loosely connected federation of nodes. This network had however to be resilient to node failures and able to scale with the growing addition of new information about data and services. The GENESI-DR scientific portal is still evolving as the project deploys the different components amongst the different partners, but the aim is to provide the connection to information, establish rights, access it and in some cases apply algorithms using the computer power available on the infrastructure with simple interfaces. As information is discovered in the network, it can be further exploited, filtered or enhanced according to the user goals. To implement this vision two specialized graphical interfaces were designed on the portal. The first, concentrates on the text-based search of information, while the second is a command and control of submission and order status on a distributed processing environment. The text search uses natural language features that extract the spatial temporal components from the user query. This is then propagated to the nodes by mapping them to OpenSearch extensions, and then returned to the user as an aggregated list of the resources. These can either be access points to dataset series or services that can be further analysed and processed. At this stage, the user is presented with dedicated interfaces that correspond to context of the action that is performing. Be it a bulk data download, data processing or data mining, the different services offer specialized interfaces that are integrated on the portal. In the overall, the GENESI-DR project identifies best practices and supporting context for the use of a minimal abstract model to loosely connect a federation of Digital Repositories. Surpassing the apparent lack of cost effectiveness of the Spatial Data Infrastructures effort in developing "catalogue services" is achieved by trimming the use cases to the most common and relevant. The GENESI-DR scientific portal is, as such, the visible front-end of a dedicated infrastructure providing transparent access to information and allowing Earth Science communities to easily and quickly derive objective information and share knowledge based on all environmentally sensitive domains.

SPES-2, AP600 intergral system test S01007 2 inch CL to core make-up tank pressure balance line break

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bacchiani, M.; Medich, C.; Rigamonti, M.

1995-09-01

The SPES-2 is a full height, full pressure experimental test facility reproducing the Westinghouse AP600 reactor with a scaling factor of 1/395. The experimental plant, designed and operated by SIET in Piacenza, consists of a full simulation of the AP600 primary core cooling system including all the passive and active safety systems. In 1992, Westinghouse, in cooperation with ENEL (Ente Nazionale per l` Energia Elettrica), ENEA (Enter per le numove Technlogie, l` Energia e l` Ambient), Siet (Societa Informazioni Esperienze Termoidraulich) and ANSALDO developed an experimental program to test the integrated behaviour of the AP600 passive safety systems. The SPES-2more » test matrix, concluded in November 1994, has examined the AP600 passive safety system response for a range of small break LOCAs at different locations on the primary system and on the passive system lines; single steam generator tube ruptures with passive and active safety systems and a main steam line break transient to demonstrate the boration capability of passive safety systems for rapid cooldown. Each of the tests has provided detailed experimental results for verification of the capability of the analysis methods to predict the integrated passive safety system behaviour. Cold and hot shakedown tests have been performed on the facility to check the characteristics of the plant before starting the experimental campaign. The paper first presents a description of the SPES-2 test facility then the main results of S01007 test {open_quotes}2{close_quotes} Cold Leg (CL) to Core Make-up Tank (CMT) pressure balance line break{close_quotes} are reported and compared with predictions performed using RELAP5/mod3/80 obtained by ANSALDO through agreement with U.S.N.R.C. (U.S. Nuclear Regulatory Commission). The SPES-2 nodalization and all the calculations here presented were performed by ANSALDO and sponsored by ENEL as a part of pre-test predictions for SPES-2.« less

The Ligurian Cluster for Marine Technologies (DLTM): matching local research and industrial needs on oceanographic data.

NASA Astrophysics Data System (ADS)

Stroobant, M.; Locritani, M.; Marini, D.; Sabbadini, L.; Carmisciano, C.; Manzella, G.; Magaldi, M.; Aliani, S.

2012-04-01

DLTM is the Ligurian Region (north Italy) cluster of Centre of Excellence (CoE) in waterborne technologies, that involves about 120 enterprises - of which, more than 100 SMEs -, the University of Genoa, all the main National Research Centres dealing with maritime and marine technologies established in Liguria (CNR, INGV, ENEA-UTMAR), the NATO Undersea Research Centre (NURC) and the Experimental Centre of the Italian Navy (CSSN), the Bank, the Port Authority and the Chamber of Commerce of the city of La Spezia. Following its mission, DLTM has recently established three Collaborative Research Laboratories focused on: 1. Computational Fluid dynamics (CFD_Lab) 2. High Performance Computing (HPC_Lab) 3. Monitoring and Analysis of Marine Ecosystems (MARE_Lab). The main role of them is to improve the relationships among the research centres and the enterprises, encouraging a systematic networking approach and sharing of knowledge, data, services, tools and human resources. Two of the key objectives of Lab_MARE are the establishment of: - an integrated system of observation and sea forecasting; - a Regional Marine Instrument Centre (RMIC) for oceanographic and metereological instruments (assembled using 'shared' tools and facilities). Besides, an important and innovative research project has been recently submitted to the Italian Ministry for Education, University and Research (MIUR). This project, in agreement with the European Directives (COM2009 (544)), is aimed to develop a Management Information System (MIS) for oceanographic and meteorological data in the Mediterranean Sea. The availability of adequate HPC inside DLTM is, of course, an important asset for achieving useful results; for example, the Regional Ocean Modeling System (ROMS) model is currently running on a high-resolution mesh on the cluster to simulate and reproduce the circulation within the Ligurian Sea. ROMS outputs will have broad and multidisciplinary impacts because ocean circulation affects the dispersion of different substances like oil spills and other pollutants but also sediments, nutrients and larvae. This could be an important tool for the environmental preservation, prevention and remediation, by placing the bases for the integrated management of the ocean.

GENESI-DR: Discovery, Access and on-Demand Processing in Federated Repositories

NASA Astrophysics Data System (ADS)

Cossu, Roberto; Pacini, Fabrizio; Parrini, Andrea; Santi, Eliana Li; Fusco, Luigi

2010-05-01

GENESI-DR (Ground European Network for Earth Science Interoperations - Digital Repositories) is a European Commission (EC)-funded project, kicked-off early 2008 lead by ESA; partners include Space Agencies (DLR, ASI, CNES), both space and no-space data providers such as ENEA (I), Infoterra (UK), K-SAT (N), NILU (N), JRC (EU) and industry as Elsag Datamat (I), CS (F) and TERRADUE (I). GENESI-DR intends to meet the challenge of facilitating "time to science" from different Earth Science disciplines in discovery, access and use (combining, integrating, processing, …) of historical and recent Earth-related data from space, airborne and in-situ sensors, which are archived in large distributed repositories. In fact, a common dedicated infrastructure such as the GENESI-DR one permits the Earth Science communities to derive objective information and to share knowledge in all environmental sensitive domains over a continuum of time and a variety of geographical scales so addressing urgent challenges such as Global Change. GENESI-DR federates data, information and knowledge for the management of our fragile planet in line with one of the major goals of the many international environmental programmes such as GMES, GEO/GEOSS. As of today, 12 different Digital Repositories hosting more than 60 heterogeneous dataset series are federated in GENESI-DR. Series include satellite data, in situ data, images acquired by airborne sensors, digital elevation models and model outputs. ESA has started providing access to: Category-1 data systematically available on Internet; level 3 data (e.g., GlobCover map, MERIS Global Vegetation Index); ASAR products available in ESA Virtual Archive and related to the Supersites initiatives. In all cases, existing data policies and security constraints are fully respected. GENESI-DR also gives access to Grid and Cloud computing resources allowing authorized users to run a number of different processing services on the available data. The GENESI-DR operational platform is currently being validated against several applications from different domains, such as: automatic orthorectification of SPOT data; SAR Interferometry; GlobModel results visualization and verification by comparison with satellite observations; ozone estimation from ERS-GOME products and comparison with in-situ LIDAR measures; access to ocean-related heterogeneous data and on-the-fly generated products. The project is adopting, ISO 19115, ISO 19139 and OGC standards for geospatial metadata discovery and processing, is compliant with the basis of INSPIRE Implementing Rules for Metadata and Discovery, and uses the OpenSearch protocol with Geo extensions for data and services discovery. OpenSearch is now considered by OGC a mass-market standard to provide machine accessible search interface to data repositories. GENESI-DR is gaining momentum in the Earth Science community thanks to the active participation to the GEO task force "Data Integration and Analysis Systems" and to the several collaborations with EC projects. It is now extending international cooperation agreements specifically with the NASA (Goddard Earth Sciences Data Information Services), with CEODE (the Center of Earth Observation for Digital Earth of Beijing), with the APN (Asia-Pacific Network), with University of Tokyo (Japanese GeoGrid and Data Integration and Analysis System).

Radiation hardness test of un-doped CsI crystals and Silicon Photomultipliers for the Mu2e calorimeter

NASA Astrophysics Data System (ADS)

Baccaro, S.; Cemmi, A.; Cordelli, M.; Diociaiuti, E.; Donghia, R.; Giovannella, S.; Loreti, S.; Miscetti, S.; Pillon, M.; Sarra, I.

2017-11-01

The Mu2e calorimeter is composed by 1400 un-doped CsI crystals coupled to large area UV extended Silicon Photomultipliers arranged in two annular disks. This calorimeter has to provide precise information on energy, timing and position. It should also be fast enough to handle the high rate background and it must operate and survive in a high radiation environment. Simulation studies estimated that, in the hottest regions, each crystal will absorb a dose of 300 Gy and will be exposed to a neutron fluency of 6 × 1011 n/cm2 in 3 years of running. Test of un-doped CsI crystals irradiated up to 900 Gy and to a neutron fluency up to 9 × 1011 n/cm2 have been performed at CALLIOPE and FNG ENEA facilities in Italy. We present our study on the variation of light yield (LY) and longitudinal response uniformity (LRU) of these crystals after irradiation. The ionization dose does not modify LRU while a 20% reduction in LY is observed at 900 Gy. Similarly, the neutron flux causes an acceptable LY deterioration (≤ 15%). A neutron irradiation test on different types of SIPMs (two different array models from Hamamatsu and one from FBK) have also been carried out by measuring the variation of the leakage current and the charge response to an ultraviolet led. We concluded that, in the experiment, we will need to cool down the SIPMs to 0 °C reduce the leakage current to an acceptable level.

A new small-footprint external-beam PIXE facility for cultural heritage applications using pulsed proton beams

NASA Astrophysics Data System (ADS)

Vadrucci, M.; Bazzano, G.; Borgognoni, F.; Chiari, M.; Mazzinghi, A.; Picardi, L.; Ronsivalle, C.; Ruberto, C.; Taccetti, F.

2017-09-01

In the framework of the COBRA project, elemental analyses of cultural heritage objects based on the particle induced X-ray emission (PIXE) are planned in a collaboration between the APAM laboratory of ENEA-Frascati and the LABEC laboratory of INFN in Florence. With this aim a 3-7 MeV pulsed proton beam, driven by the injector of the protontherapy accelerator under construction for the TOP-IMPLART project, will be used to demonstrate the feasibility of the technique with a small-footprint pulsed accelerator to Italian small and medium enterprises interested in the composition analysis of ancient artifacts. The experimental set-up for PIXE analysis on the TOP-IMPLART machine consists of a modified assembly of the vertical beam line usually dedicated to radiobiology experiments: the beam produced by the injector (RFQ + DTL, a PL7 ACCSYSHITACHI model) is bent to 90° by a magnet, is collimated by a 300 μm aperture inserted in the end nozzle and extracted into ambient pressure by an exit window consisting of a Upilex foil 7.5 μm thick. The beam is pulsed with a variable pulse duration of 20-100 μs and a repetition rate variable from 10 to 100 Hz. The X-ray detection system is based on a Ketek Silicon Drift Detector (SDD) with 7 mm2 active area and 450 μm thickness, with a thin Beryllium entrance window (8 μm). The results of the calibration of this new PIXE set-up using thick target standards and of the analysis of the preliminary measurements on pigments are presented.

Irradiation study of UV Silicon Photomultipliers for the Mu2e calorimeter

NASA Astrophysics Data System (ADS)

Baccaro, S.; Cemmi, A.; Cordelli, M.; Diociaiuti, E.; Donghia, R.; Ferrari, A.; Giovannella, S.; Loreti, S.; Miscetti, S.; Müller, S.; Pillon, M.; Sarra, I.

2017-02-01

The Mu2e calorimeter is composed of 1400 un-doped CsI crystals, coupled to large area UV extended Silicon Photomultipliers (SiPMs), arranged in two annular disks. This calorimeter has to provide precise information on energy, timing and position resolutions. It should also be fast enough to handle the high rate background and it must operate and survive in the high radiation environment. Simulation studies estimated that, in the highest irradiated regions, each photo-sensor will absorb a dose of 20 krad and will be exposed to a neutron fluency of 5.5×1011n1 MeV/cm2 in three years of running, with a safety factor of 3 included. At the end of 2015, we have concluded an irradiation campaign at the Frascati Neutron Generator (FNG, Frascati, Italy) measuring the response of two different 16 array models from Hamamatsu, which differ for the protection windows and a SiPM from FBK. In 2016, we have carried out two additional irradiation campaigns with neutrons and photons at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR, Dresden, Germany) and at the Calliope gamma irradiation facility at ENEA-Casaccia, respectively. A negligible increment of the leakage current and no gain change have been observed with the dose irradiation. On the other hand, at the end of the neutron irradiation, the gain does not show large changes whilst the leakage current increases by around a factor of 2000. In these conditions, the too high leakage current makes problematic to bias the SiPMs, thus requiring to cool them down to a running temperature of ~0oC.

Patient safety and adverse events related with obstetric care.

PubMed

Aibar, Laura; Rabanaque, María José; Aibar, Carlos; Aranaz, Jesús María; Mozas, Juan

2015-04-01

To determine the frequency and distribution of Adverse Events (AE) in obstetrics departments at Spanish hospitals. We present a retrospective cohort study including 816 women admitted to the obstetrics departments at 41 hospitals that took part in the National Adverse Effects Study in Spain (ENEAS) and an extension of this study in all hospitals located in two Autonomous Regions. To identify AE, nurses from each participating hospital examined all medical records, and completed a validated screening guide. A team of external reviewers evaluated the medical records of all women who met at least one of the criteria in the screening guide to verify all AE. The main outcome measure was the incidence of AE during hospitalization. The cumulative incidence of patients with obstetric care-related AE was 3.6% (95% CI 2.3-4.8). The most frequent AE were those related with surgical interventions or procedures (59.4%). None of the AE detected were considered severe. 36.7% of the AE lengthened the woman's hospital stay, and 13.3% led to hospital admission. Additional procedures were needed after 71.9% of the AE, and additional treatment was needed after 59.4%. 56.3% of the AE were considered preventable. Obstetric care is characterized by generally younger ages among patients, their low frequency of comorbidities and high expectations for successful outcomes of care. However, some factors can increase obstetric risk and favor the appearance of preventable incidents and AE. Systems are needed to detect preventable AE, and measures are needed to reduce risks or attenuate their consequences.

The Physics and Applications of High Brightness Beams: Working Group C Summary on Applications to FELS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nuhn, Heinz-Dieter

2003-03-19

This is the summary of the activities in working group C, ''Application to FELs,'' which was based in the Bithia room at the Joint ICFA Advanced Accelerator and Beam Dynamics Workshop on July 1-6, 2002 in Chia Laguna, Sardinia, Italy. Working group C was small in relation to the other working groups at that workshop. Attendees include Enrica Chiadroni, University of Rome ape with an identical pulse length. ''La Sapienza'', Luca Giannessi, ENEA, Steve Lidia, LBNL, Vladimir Litvinenko, Duke University, Patrick Muggli, UCLA, Alex Murokh, UCLA, Heinz-Dieter Nuhn, SLAC, Sven Reiche, UCLA, Jamie Rosenzweig, UCLA, Claudio Pellegrini, UCLA, Susan Smith,more » Daresbury Laboratory, Matthew Thompson, UCLA, Alexander Varfolomeev, Russian Research Center, plus a small number of occasional visitors. The working group addressed a total of nine topics. Each topic was introduced by a presentation, which initiated a discussion of the topic during and after the presentation. The speaker of the introductory presentation facilitated the discussion. There were six topics that were treated in stand-alone sessions of working group C. In addition, there were two joint sessions, one with working group B, which included one topic, and one with working group C, which included two topics. The presentations that were given in the joint sessions are summarized in the working group summary reports for groups B and D, respectively. This summary will only discuss the topics that were addressed in the stand-alone sessions, including Start-To-End Simulations, SASE Experiment, PERSEO, ''Optics Free'' FEL Oscillators, and VISA II.« less

PLASMA-2013: International Conference on Research and Applications of Plasmas (Warsaw, Poland, 2-6 September 2013)

NASA Astrophysics Data System (ADS)

Sadowski, Marek J.

2014-05-01

The PLASMA-2013 International Conference on Research and Applications of Plasmas was held in Warsaw (Poland) from 2 to 6 September 2013. The conference was organized by the Institute of Plasma Physics and Laser Microfusion, under the auspices of the Polish Physical Society. The scope of the PLASMA conferences, which have been organized every two years since 1993, covers almost all issues of plasma physics and fusion research as well as selected problems of plasma technology. The PLASMA-2013 conference topics included: •Elementary processes and general plasma physics. •Plasmas in tokamaks and stellarators (magnetic confinement fusion). •Plasmas generated by laser beams and inertial confinement fusion. •Plasmas produced by Z-pinch and plasma-focus discharges. •Low-temperature plasma physics. •Space plasmas and laboratory astrophysics. •Plasma diagnostic methods and applications of plasmas. This conference was designed not only for plasma researchers and engineers, but also for students from all over the world, in particular for those from Central and Eastern Europe. Almost 140 participants had the opportunity to hear 9 general lectures, 11 topical talks and 26 oral presentations, as well as to see and discuss around 120 posters. From about 140 contributions, after the preparation of about 100 papers and the peer review process, only 74 papers have been accepted for publication in this topical issue. Acknowledgments Acting on behalf of the International Scientific Committee I would like to express our thanks to all the invited speakers and all the participants of the PLASMA-2013 conference for their numerous contributions. In particular, I wish to thank all of the authors of papers submitted for publication in this topical issue of Physica Scripta . Particular thanks are due to all of the reviewers for their valuable reports and comments, which helped to improve the quality of many of the papers. International Scientific Committee Marek J Sadowski, NCBJ, Otwock, Poland—Chairman Dimitri Batani, Universite Bordeaux, France Sergio Ciattaglia, ITER, Cadarache, France Michael Dudeck, UPMC, Paris, France Igor E Garkusha, NSC KIPT, Kharkov, Ukraine Zbigniew Kłos, CBK PAN, Warsaw Giorgio Maddaluno, ENEA Frascati, Italy Andrea Murari, EFDA JET, Culham, UK Józef Musielok, University of Opole, Poland Svetlana Ratynskaia, RIT, Stockholm, Sweden Karel Rohlena, IP CAS, Prague, Czech Republic Valentin Smirnov, Rosatom, Moscow, Russia Francisco Tabares, CIEMAT, Madrid, Spain Lorenzo Torrisi, University of Messina, Messina, Italy Jerzy Wołowski, IFPiLM, Warsaw, Poland Urszula Woźnicka, IFJ PAN, Cracow, Poland Local Organizing Committee Jerzy Wołowski—Chairman Paweł Gąsior—Secretary Zofia Kalinowska Ewa Kowalska-Strzęciwilk Monika Kubkowska Anita Pokorska Ryszard Panfil Joanna Dziak-Beme Conference website: http://plasma2013.ipplm.pl/

Seismic and tsunami hazard investigation in Valparaiso in the framework of the project "MAR VASTO"

NASA Astrophysics Data System (ADS)

Romanelli, F.; Razafindrakoto, H.

2009-04-01

In the framework of the MAR VASTO Project ("Risk Management in Valparaíso/Manejo de Riesgos en Valparaíso"), completed in 2008 and funded by BID/IDB (Banco InterAmericano de Desarrollo/ InterAmerican Development Bank), managed by ENEA (Italian Agency for New Technologies, Energy and Environment), with the participation of Italian and Chilean partners and the support of local stakeholders, the most important hazards have been investigated carried out. Valparaíso represents a distinctive case of growth, inside a remarkable landscape, of an important Pacific Ocean seaport (over the 19th and 20th centuries), up to reaching a strategic importance in shipping trade, declined after the Panama Canal opening (1914). Thus, Valparaíso tells the never-ending story of a tight interaction between society and environment, stratifying different urban and architectonic layers, sometimes struck by disasters and always in danger. Certainly, the city has been subjected to various natural hazards (seismic events, but also tsunamis, landslides, etc.) and anthropic calamities (mainly wild and human-induced fires). These features make Valparaíso a paradigmatic study case about hazard mitigation, and risk factors must be very well evaluated during the restoration phases to be planned in the future. Seismic Hazrad. The major goal is to provide a dataset of synthetic time series representative of the potential ground motion at the bedrock of Valparaiso, especially at selected sites (e.g. the three important churches located in the Valparaiso urban area: La Matriz, San Francisco, Las Hermanitas de la Providencia), for different scenarios; the characteristics of the calculated signals (e.g. amplitude, frequency content and duration of shaking) are determined by the earthquake source process and the wave propagation effects of the path between the source and the site. The synthetic signals, to be used as seismic input in a subsequent engineering analysis, have been produced at a very low cost/benefit ratio taking into account a broad range of source characteristics, path and local (geological and geotechnical) conditions. The realistic modeling of ground motion requires the simultaneous knowledge of the geotechnical, lithological, geophysical parameters and topography of the medium, on one side, and tectonic, historical, paleoseismological, seismotectonic models, on the other, for the best possible definition of the probable seismic source. Many parametric studies of the ground motion have been performed, taking into account the variations due to the choice of the focal mechanism parameters, the geometry of the seismic source and the rupture process. Tsunami Hazard. The Chilean coast is currently exposed to the effects of near and far field tsunamis generated in the Pacific Ocean. For instance, the catastrophic events of the last century, 1868 and 1877, overwhelmed the coast of the northern region of the country. This historic situation has contributed to an awareness of the risk involved and therefore to the development of research on the subject in Chile. The organisation in charge of detecting and issuing the warning is the Hydrographic and Oceanographic Service of the Chilean Navy (SHOA). The SHOA report has been used as the reference document for the tsunami hazard assessement for the Valparaiso site and it has been complemented with a) set of parametric studies about the tsunamigenic potential of the 1985 and 1906 scenario earthquakes; b) analytical modelling of tsunami waveforms for different scenarios, in order to provide a complementary dataset to be used for the tsunami hazard assessment at Valparaiso. Using as a base of knowledge the inundation map provided by SHOA associated to the 1906 event, an upper bound of the multiplication factor for the tsunami hazard associated to be used for the different scenarios has been obtained.

Accurate Wavelength Measurements and Modeling of Fe XV to Fe XIX Spectra Recorded in High-Density Plasmas between 13.5 and 17 Å

NASA Astrophysics Data System (ADS)

May, M. J.; Beiersdorfer, P.; Dunn, J.; Jordan, N.; Hansen, S. B.; Osterheld, A. L.; Faenov, A. Ya.; Pikuz, T. A.; Skobelev, I. Yu.; Flora, F.; Bollanti, S.; Di Lazzaro, P.; Murra, D.; Reale, A.; Reale, L.; Tomassetti, G.; Ritucci, A.; Francucci, M.; Martellucci, S.; Petrocelli, G.

2005-06-01

Iron spectra have been recorded from plasmas created at three different laser plasma facilities: the Tor Vergata University laser in Rome (Italy), the Hercules laser at ENEA in Frascati (Italy), and the Compact Multipulse Terawatt (COMET) laser at LLNL in California (USA). The measurements provide a means of identifying dielectronic satellite lines from Fe XVI and Fe XV in the vicinity of the strong 2p-->3d transitions of Fe XVII. About 80 Δn>=1 lines of Fe XV (Mg-like) to Fe XIX (O-like) were recorded between 13.8 and 17.1 Å with a high spectral resolution (λ/Δλ~4000) about 30 of these lines are from Fe XVI and Fe XV. The laser-produced plasmas had electron temperatures between 100 and 500 eV and electron densities between 1020 and 1022 cm-3. The Hebrew University Lawrence Livermore Atomic Code (HULLAC) was used to calculate the atomic structure and atomic rates for Fe XV-XIX. HULLAC was used to calculate synthetic line intensities at Te=200 eV and ne=1021 cm-3 for three different conditions to illustrate the role of opacity: optically thin plasmas with no excitation-autoionization/dielectronic recombination (EA/DR) contributions to the line intensities, optically thin plasmas that included EA/DR contributions to the line intensities, and optically thick plasmas (optical depth ~200 μm) that included EA/DR contributions to the line intensities. The optically thick simulation best reproduced the recorded spectrum from the Hercules laser. However, some discrepancies between the modeling and the recorded spectra remain.

Natural circulation in a liquid metal one-dimensional loop

NASA Astrophysics Data System (ADS)

Tarantino, M.; De Grandis, S.; Benamati, G.; Oriolo, F.

2008-06-01

A wide use of pure lead, as well as its alloys (such as lead-bismuth, lead-lithium), is foreseen in several nuclear-related fields: it is studied as coolant in critical and sub-critical nuclear reactors, as spallation target for neutron generation in several applications and for tritium generation in fusion systems. In this framework, a new facility named NAtural CIrculation Experiment (NACIE), has been designed at ENEA-Brasimone Research Centre. NACIE is a rectangular loop, made by stainless steel pipes. It consists mainly of a cold and hot leg and an expansion tank installed on the top of the loop. A fuel bundle simulator, made by three electrical heaters placed in a triangular lattice, is located in the lower part of the cold leg, while a tube in tube heat exchanger is installed in the upper part of the hot leg. The adopted secondary fluid is THT oil, while the foreseen primary fluid for the tests is lead-bismuth in eutectic composition (LBE). The aim of the facility is to carry out experimental tests of natural circulation and collect data on the heat transfer coefficient (HTC) for heavy liquid metal flowing through rod bundles. The paper is focused on the preliminary estimation of the LBE flow rate along the loop. An analytical methodology has been applied, solving the continuity, momentum and energy transport equations under appropriate hypothesis. Moreover numerical simulations have been performed. The FLUENT 6.2 CFD code has been utilized for the numerical simulations. The main results carried out from the pre-tests simulations are illustrated in the paper, and a comparison with the theoretical estimations is done.

Copper benchmark experiment for the testing of JEFF-3.2 nuclear data for fusion applications

NASA Astrophysics Data System (ADS)

Angelone, M.; Flammini, D.; Loreti, S.; Moro, F.; Pillon, M.; Villar, R.; Klix, A.; Fischer, U.; Kodeli, I.; Perel, R. L.; Pohorecky, W.

2017-09-01

A neutronics benchmark experiment on a pure Copper block (dimensions 60 × 70 × 70 cm3) aimed at testing and validating the recent nuclear data libraries for fusion applications was performed in the frame of the European Fusion Program at the 14 MeV ENEA Frascati Neutron Generator (FNG). Reaction rates, neutron flux spectra and doses were measured using different experimental techniques (e.g. activation foils techniques, NE213 scintillator and thermoluminescent detectors). This paper first summarizes the analyses of the experiment carried-out using the MCNP5 Monte Carlo code and the European JEFF-3.2 library. Large discrepancies between calculation (C) and experiment (E) were found for the reaction rates both in the high and low neutron energy range. The analysis was complemented by sensitivity/uncertainty analyses (S/U) using the deterministic and Monte Carlo SUSD3D and MCSEN codes, respectively. The S/U analyses enabled to identify the cross sections and energy ranges which are mostly affecting the calculated responses. The largest discrepancy among the C/E values was observed for the thermal (capture) reactions indicating severe deficiencies in the 63,65Cu capture and elastic cross sections at lower rather than at high energy. Deterministic and MC codes produced similar results. The 14 MeV copper experiment and its analysis thus calls for a revision of the JEFF-3.2 copper cross section and covariance data evaluation. A new analysis of the experiment was performed with the MCNP5 code using the revised JEFF-3.3-T2 library released by NEA and a new, not yet distributed, revised JEFF-3.2 Cu evaluation produced by KIT. A noticeable improvement of the C/E results was obtained with both new libraries.

Accurate wavelength measurements and modeling of FeXV to FeXIX spectra recorded in high density plasmas between 13.5 to 17 A.

DOE Office of Scientific and Technical Information (OSTI.GOV)

May, M; Beiersdorfer, P; Dunn, J

Iron spectra have been recorded from plasmas created at three different laser plasma facilities, the Tor Vergata University laser in Rome (Italy), the Hercules laser at ENEA in Frascati (Italy), and the Compact Multipulse Terawatt (COMET) laser at LLNL in California (USA). The measurements provide a means of identifying dielectronic satellite lines from FeXVI and FeXV in the vicinity of the strong 2p {yields} 3d transitions of FeXVII. About 80 {Delta}n {ge} 1 lines of FeXV (Mg-like) to FeXIX (O-like) were recorded between 13.8 to 17.1 {angstrom} with a high spectral resolution ({lambda}/{Delta}{lambda} {approx} 4000), about thirty of these linesmore » are from FeXVI and FeXV. The laser produced plasmas had electron temperatures between 100 to 500 eV and electron densities between 10{sup 20} to 10{sup 22} cm{sup -3}. The Hebrew University Lawrence Livermore Atomic Code (HULLAC) was used to calculate the atomic structure and atomic rates for FeXV to FeXIX. HULLAC was used to calculate synthetic line intensities at T{sub e} = 200 eV and n{sub e} = 10{sup 21}cm{sup -3} for three different conditions to illustrate the role of opacity: optically thin plasmas with no excitation-autoionization/dielectronic recombination (EA/DR) contributions to the line intensities, optically thin plasmas that included EA/DR contributions to the line intensities, and optically thick plasmas (optical depth {approx} 200 {micro}m) that included EA/DR contributions to the line intensities. The optically thick simulation best reproduced the recorded spectrum from the Hercules laser. However some discrepancies between the modeling and the recorded spectra remain.« less

Pre-test analysis of protected loss of primary pump transients in CIRCE-HERO facility

NASA Astrophysics Data System (ADS)

Narcisi, V.; Giannetti, F.; Del Nevo, A.; Tarantino, M.; Caruso, G.

2017-11-01

In the frame of LEADER project (Lead-cooled European Advanced Demonstration Reactor), a new configuration of the steam generator for ALFRED (Advanced Lead Fast Reactor European Demonstrator) was proposed. The new concept is a super-heated steam generator, double wall bayonet tube type with leakage monitoring [1]. In order to support the new steam generator concept, in the framework of Horizon 2020 SESAME project (thermal hydraulics Simulations and Experiments for the Safety Assessment of MEtal cooled reactors), the ENEA CIRCE pool facility will be refurbished to host the HERO (Heavy liquid mEtal pRessurized water cOoled tubes) test section to investigate a bundle of seven full scale bayonet tubes in ALFRED-like thermal hydraulics conditions. The aim of this work is to verify thermo-fluid dynamic performance of HERO during the transition from nominal to natural circulation condition. The simulations have been performed with RELAP5-3D© by using the validated geometrical model of the previous CIRCE-ICE test section [2], in which the preceding heat exchanger has been replaced by the new bayonet bundle model. Several calculations have been carried out to identify thermal hydraulics performance in different steady state conditions. The previous calculations represent the starting points of transient tests aimed at investigating the operation in natural circulation. The transient tests consist of the protected loss of primary pump, obtained by reducing feed-water mass flow to simulate the activation of DHR (Decay Heat Removal) system, and of the loss of DHR function in hot conditions, where feed-water mass flow rate is absent. According to simulations, in nominal conditions, HERO bayonet bundle offers excellent thermal hydraulic behavior and, moreover, it allows the operation in natural circulation.

Drinking water contamination from perfluoroalkyl substances (PFAS): an ecological mortality study in the Veneto Region, Italy.

PubMed

Mastrantonio, Marina; Bai, Edoardo; Uccelli, Raffaella; Cordiano, Vincenzo; Screpanti, Augusto; Crosignani, Paolo

2018-02-01

Perfluoroalkyl substances (PFAS), a heterogeneous group of highly stable man-made chemicals, have been widely used since 1960s and can be detected almost ubiquitously in all environmental matrices. In Italy, on January 2014, drinking water contamination in an area of the Veneto Region was detected mainly due to the drain of fluorinated chemicals by a manufacturing company operating since 1964. The present ecological mortality study was aimed at comparing mortality for some causes of death selected on the basis of previous reported associations, during the period 1980-2013, in municipalities with PFAS contaminated and uncontaminated drinking water on the basis of the levels indicated by the Italian National Health Institute (ISS). Sex-specific number, standardized mortality rates and rate ratios (RR) for PFAS contaminated and uncontaminated areas were computed for each cause of death through the ENEA epidemiological database. In both sexes, statistically significant RRs were detected for all causes mortality, diabetes, cerebrovascular diseases, myocardial infarction and Alzheimer's disease. In females, RRs significantly higher than 1.0 were also observed for kidney and breast cancer, and Parkinson's disease. Increased risk, although not statistically significant, was observed for bladder cancer in both sexes, and for testicular cancer, pancreatic cancer and leukemia in males only. Higher mortality levels for some causes of death, possibly associated with PFAS exposure, were detected in contaminated municipalities in comparison with uncontaminated ones with similar socioeconomic status and smoking habits. These results warrant further individual level analytic studies to delineate casual associations. © The Author 2017. Published by Oxford University Press on behalf of the European Public Health Association. All rights reserved.

[Regional Study of Patient Safety Incidents (ERIDA) in the Emergency Services].

PubMed

Alcaraz-Martínez, J; Aranaz-Andrés, J M; Martínez-Ros, C; Moreno-Reina, S; Escobar-Álvaro, L; Ortega-Liarte, J V

2016-01-01

Evaluate the patient safety incidents that occur in the emergency departments of our region. Observational study conducted in all the hospital emergency departments in the Regional Health Service of Murcia. After systematic random sampling, data were collected during care and a week later by telephone survey. Health professionals of each service were trained and collected the information, following the methodology of the National Study of Adverse Events Related to Hospitalization -ENEAS- and the Adverse Events Related to Spanish Hospital Emergency Department Care -EVADUR-. A total of 393 samples were collected, proportional to the cases treated in each hospital. In 10 cases (3.1%) the complaint was a previous safety incident. At least one incident was detected in 47 patients (11.95%; 8.7 to 15.1%). In 3 cases there were 2 incidents, bringing the number of incidents to 50. Regarding the impact, the 51% of incidents caused harm to the patients. The effects more frequent in patients were the need for repeat visits (9 cases), and mismanagement of pain (8 cases). In 24 cases (51.1%) health care was not affected, although 3 cases required an additional test, 11 cases required further consultation, and led to hospitalisation in 2 cases. The most frequent causal factors of these incidents were medication (14) and care (12). The incidents were considered preventable in 60% of cases. A rate of incidents in the emergency departments, representative of the region, has been obtained. The implications of the results for the population means that 12 out of every 100 patients treated in emergency departments have an adverse event, and 7 of these are avoidable. Copyright © 2016 SECA. Publicado por Elsevier España, S.L.U. All rights reserved.

Towards a HPC-oriented parallel implementation of a learning algorithm for bioinformatics applications

PubMed Central

2014-01-01

Background The huge quantity of data produced in Biomedical research needs sophisticated algorithmic methodologies for its storage, analysis, and processing. High Performance Computing (HPC) appears as a magic bullet in this challenge. However, several hard to solve parallelization and load balancing problems arise in this context. Here we discuss the HPC-oriented implementation of a general purpose learning algorithm, originally conceived for DNA analysis and recently extended to treat uncertainty on data (U-BRAIN). The U-BRAIN algorithm is a learning algorithm that finds a Boolean formula in disjunctive normal form (DNF), of approximately minimum complexity, that is consistent with a set of data (instances) which may have missing bits. The conjunctive terms of the formula are computed in an iterative way by identifying, from the given data, a family of sets of conditions that must be satisfied by all the positive instances and violated by all the negative ones; such conditions allow the computation of a set of coefficients (relevances) for each attribute (literal), that form a probability distribution, allowing the selection of the term literals. The great versatility that characterizes it, makes U-BRAIN applicable in many of the fields in which there are data to be analyzed. However the memory and the execution time required by the running are of O(n3) and of O(n5) order, respectively, and so, the algorithm is unaffordable for huge data sets. Results We find mathematical and programming solutions able to lead us towards the implementation of the algorithm U-BRAIN on parallel computers. First we give a Dynamic Programming model of the U-BRAIN algorithm, then we minimize the representation of the relevances. When the data are of great size we are forced to use the mass memory, and depending on where the data are actually stored, the access times can be quite different. According to the evaluation of algorithmic efficiency based on the Disk Model, in order to reduce the costs of the communications between different memories (RAM, Cache, Mass, Virtual) and to achieve efficient I/O performance, we design a mass storage structure able to access its data with a high degree of temporal and spatial locality. Then we develop a parallel implementation of the algorithm. We model it as a SPMD system together to a Message-Passing Programming Paradigm. Here, we adopt the high-level message-passing systems MPI (Message Passing Interface) in the version for the Java programming language, MPJ. The parallel processing is organized into four stages: partitioning, communication, agglomeration and mapping. The decomposition of the U-BRAIN algorithm determines the necessity of a communication protocol design among the processors involved. Efficient synchronization design is also discussed. Conclusions In the context of a collaboration between public and private institutions, the parallel model of U-BRAIN has been implemented and tested on the INTEL XEON E7xxx and E5xxx family of the CRESCO structure of Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), developed in the framework of the European Grid Infrastructure (EGI), a series of efforts to provide access to high-throughput computing resources across Europe using grid computing techniques. The implementation is able to minimize both the memory space and the execution time. The test data used in this study are IPDATA (Irvine Primate splice- junction DATA set), a subset of HS3D (Homo Sapiens Splice Sites Dataset) and a subset of COSMIC (the Catalogue of Somatic Mutations in Cancer). The execution time and the speed-up on IPDATA reach the best values within about 90 processors. Then the parallelization advantage is balanced by the greater cost of non-local communications between the processors. A similar behaviour is evident on HS3D, but at a greater number of processors, so evidencing the direct relationship between data size and parallelization gain. This behaviour is confirmed on COSMIC. Overall, the results obtained show that the parallel version is up to 30 times faster than the serial one. PMID:25077818

Towards a HPC-oriented parallel implementation of a learning algorithm for bioinformatics applications.

PubMed

D'Angelo, Gianni; Rampone, Salvatore

2014-01-01

The huge quantity of data produced in Biomedical research needs sophisticated algorithmic methodologies for its storage, analysis, and processing. High Performance Computing (HPC) appears as a magic bullet in this challenge. However, several hard to solve parallelization and load balancing problems arise in this context. Here we discuss the HPC-oriented implementation of a general purpose learning algorithm, originally conceived for DNA analysis and recently extended to treat uncertainty on data (U-BRAIN). The U-BRAIN algorithm is a learning algorithm that finds a Boolean formula in disjunctive normal form (DNF), of approximately minimum complexity, that is consistent with a set of data (instances) which may have missing bits. The conjunctive terms of the formula are computed in an iterative way by identifying, from the given data, a family of sets of conditions that must be satisfied by all the positive instances and violated by all the negative ones; such conditions allow the computation of a set of coefficients (relevances) for each attribute (literal), that form a probability distribution, allowing the selection of the term literals. The great versatility that characterizes it, makes U-BRAIN applicable in many of the fields in which there are data to be analyzed. However the memory and the execution time required by the running are of O(n(3)) and of O(n(5)) order, respectively, and so, the algorithm is unaffordable for huge data sets. We find mathematical and programming solutions able to lead us towards the implementation of the algorithm U-BRAIN on parallel computers. First we give a Dynamic Programming model of the U-BRAIN algorithm, then we minimize the representation of the relevances. When the data are of great size we are forced to use the mass memory, and depending on where the data are actually stored, the access times can be quite different. According to the evaluation of algorithmic efficiency based on the Disk Model, in order to reduce the costs of the communications between different memories (RAM, Cache, Mass, Virtual) and to achieve efficient I/O performance, we design a mass storage structure able to access its data with a high degree of temporal and spatial locality. Then we develop a parallel implementation of the algorithm. We model it as a SPMD system together to a Message-Passing Programming Paradigm. Here, we adopt the high-level message-passing systems MPI (Message Passing Interface) in the version for the Java programming language, MPJ. The parallel processing is organized into four stages: partitioning, communication, agglomeration and mapping. The decomposition of the U-BRAIN algorithm determines the necessity of a communication protocol design among the processors involved. Efficient synchronization design is also discussed. In the context of a collaboration between public and private institutions, the parallel model of U-BRAIN has been implemented and tested on the INTEL XEON E7xxx and E5xxx family of the CRESCO structure of Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), developed in the framework of the European Grid Infrastructure (EGI), a series of efforts to provide access to high-throughput computing resources across Europe using grid computing techniques. The implementation is able to minimize both the memory space and the execution time. The test data used in this study are IPDATA (Irvine Primate splice- junction DATA set), a subset of HS3D (Homo Sapiens Splice Sites Dataset) and a subset of COSMIC (the Catalogue of Somatic Mutations in Cancer). The execution time and the speed-up on IPDATA reach the best values within about 90 processors. Then the parallelization advantage is balanced by the greater cost of non-local communications between the processors. A similar behaviour is evident on HS3D, but at a greater number of processors, so evidencing the direct relationship between data size and parallelization gain. This behaviour is confirmed on COSMIC. Overall, the results obtained show that the parallel version is up to 30 times faster than the serial one.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Klix, A.; Fischer, U.; Raj, P.

Fusion power reactors will rely on the internal production of the fuel tritium from lithium in the tritium breeding blanket. Test Blanket Modules (TBM) will be installed in ITER with the aim to investigate the nuclear performance of different breeding blanket designs. Currently there is no fully qualified nuclear instrumentation available for the measurement of neutron fluxes and tritium production rates which would be able to withstand the harsh environment conditions in the TBM such as high temperature (>400 deg. C) and, depending on the operation scenario, intense radiation levels. As partner of the European Consortium on Nuclear Data andmore » Measurement Techniques in the framework of several F4E specific grants and contracts, KIT and ENEA have jointly studied the possibility to develop and test detectors suitable to operate in ITER-TBMs. Here we present an overview of ongoing work on three types of neutron flux monitors under development for the TBMs with focus on the KIT activities. A neutron activation system (NAS) with pneumatic sample transport could provide absolute neutron flux measurements in selected positions. A test system for investigating activation materials with short half-lives was constructed at the DT neutron generator laboratory of Technical University of Dresden to investigate the neutronics aspects. Several irradiations have been performed with focus on the simultaneous measurement of the extracted activated probes. An engineering assessment of a TBM NAS in the conceptual design phase has been done which considered issues of design requirements and integration. Last but not least, a mechanical test bench is under construction at KIT which will address issues of driving the activation probes, solutions for loading the system etc. experimentally. Self-powered neutron detectors (SPND) are widely applied in fission reactor monitoring, and the commercially available SPNDs are sensitive to thermal neutrons. We are investigating novel materials for SPND which would be sensitive also to the fast neutron flux expected in the TBMs. To this end simulations were done with the European Activation System EASY and neutron flux spectra which were calculated with MCNP for the HCPB TBM. Preliminary tests with commercial SPND in a fast reactor were performed. As a result of these activities, several materials have been found which may be suitable for the measurement of fast neutron fluxes in the TBM. Test detectors are under preparation for testing with DT neutron generators. Within the I{sub S}MART project, funded by KIC InnoEnergy, KIT is developing an online detector based on silicon carbide electronics for the TBMs. The operation of such detectors at TBM relevant temperatures is expected to incur lower accumulated radiation damage to them than at room temperature due to annealing effects. Detectors of several designs have been already irradiated with DT neutrons. Irradiation tests at elevated temperatures have been done and further tests are currently underway. This paper summarizes the status of the work for these three neutron flux monitor systems. (authors)« less

La Spezia and the research network for outreach and education in marine sciences.

NASA Astrophysics Data System (ADS)

Locritani, Marina; Furia, Stefania; Giacomazzi, Fabio; Merlino, Silvia; Mori, Anna; Nacini, Francesca; Nardi, Elisabetta; Stroobant, Mascha; Talamoni, Roberta; Zocco, Olivia

2013-04-01

La Spezia is a small town located in the southeastern corner of the Liguria Region (Italy). The close relationship with the sea conditioned the ancient and recent activities of the town that embraces the namesake gulf. The Gulf of La Spezia overlooks on the Liguria Sea which is characterized by a high biodiversity, due to the heritage of coastal habitats, where numerous interesting species to preserve live, often a priority for the EC Directives. Therefore, along the Liguria arc, five coastal Marine Protected Areas have been instituted, two of them insist in La Spezia Province: the Marine Protected Areas of Cinque Terre National Park and Porto Venere Regional Park, both included in the UNESCO World Heritage Site. Moreover, the importance of the cetacean communities in the Ligurian Sea led to the establishment of the Cetacean Sanctuary. Resulting from a positive geographic coincidence, six Research Institutions are located in La Spezia: CMRE-NATO (Centre for Maritime Research and Experimentation, formerly NURC-NATO Undersea Research Centre), CNR (National Research Council), CSSN (Naval Experimentation and Support Centre - Navy), ENEA (Italian National Agency for New Technologies, Energy and Sustainable Economic Development), INGV (National Institute of Geophysics and Volcanology), Polo Universitario Marconi (University of Genoa - seat of La Spezia). These Institutions share a long time experience of work at sea and in coastal environments according to their different scientific interests (biology, engineering, geology, physic, and oceanography). Moreover, in 2009 the Liguria Region promoted the institution of the Liguria Cluster of Marine Technologies (Distretto Ligure delle Tecnologie Marine), whose core target is the regional development of marine technologies and science. This unique concentration of Research Institutes, Marine Protected Areas and sea activities (civil and military) brought to implement a collaborative network among the scientific and territorial institutions, resulting in a wealth of knowledge ready to be shared with the territory to increase economy competitiveness and raise society awareness. Marine science is a general interest topic suitable to be spread in the schools: it is multi-disciplinary and offers technological and social arguments. The Research Institutions of La Spezia deal with different fields of investigation which are complementary and integrated in a complete and effective education proposal. Results are improved by the cooperation with LABTER (Laboratorio Territoriale di Educazione Ambientale - Territory Laboratory of Environmental Education) afferent to La Spezia Municipality. This panel intends to show the activities carried out from 2009 to 2012 and resulting from the cooperation among the Research Institutions and Local Authorities to improve the education and information effectiveness in the field of marine science. Considering all the above mentioned assumptions, La Spezia is, finally, a "cultural hotspot" for marine science issues.

Hazard Evaluation in Valparaíso: the MAR VASTO Project

NASA Astrophysics Data System (ADS)

Indirli, Maurizio; Razafindrakoto, Hoby; Romanelli, Fabio; Puglisi, Claudio; Lanzoni, Luca; Milani, Enrico; Munari, Marco; Apablaza, Sotero

2011-03-01

The Project "MAR VASTO" (Risk Management in Valparaíso/Manejo de Riesgos en Valparaíso), funded by BID/IADB (Banco InterAmericano de Desarrollo/InterAmerican Development Bank), has been managed by ENEA, with an Italian/Chilean joined partnership and the support of local institutions. Valparaíso tells the never-ending story of a tight interaction between society and environment and the city has been declared a Patrimony of Humanity by UNESCO since 2003. The main goals of the project have been to evaluate in the Valparaíso urban area the impact of main hazards (earthquake, tsunami, fire, and landslide), defining scenarios and maps on a geo-referenced GIS database. In particular, for earthquake hazard assessment the realistic modelling of ground motion is a very important base of knowledge for the preparation of groundshaking scenarios which serve as a valid and economic tool to be fruitfully used by civil engineers, supplying a particularly powerful tool for the prevention aspects of Civil Defense. When numerical modelling is successfully compared with records (as in the case of the Valparaíso, 1985 earthquake), the resulting synthetic seismograms permit the generation of groundshaking maps, based upon a set of possible scenario earthquakes. Where no recordings are available for the scenario event, synthetic signals can be used to estimate ground motion without having to wait for a strong earthquake to occur (pre-disaster microzonation). For the tsunami hazard, the available reports, [e.g., SHOA (1999) Carta de Inundacion por Tsunami para la bahia de Valparaíso, Chile, http://www.shoa.cl/servicios/citsu/citsu.php], have been used as the reference documents for the hazard assessment for the Valparaíso site. The deep and detailed studies already carried out by SHOA have been complemented with (a) sets of parametric studies of the tsunamigenic potential of the 1985 and 1906 scenario earthquakes; and (b) analytical modelling of tsunami waveforms for different scenarios, in order to provide a complementary dataset to be used for the tsunami hazard assessment at Valparaíso. In addition, other targeted activities have been carried out, such as architectonic/urban planning studies/vulnerability evaluation for a pilot building stock in a historic area and a vulnerability analysis for three monumental churches. In this paper, a general description of the work is given, taking into account the in situ work that drove the suggestion of guidelines for mitigation actions.

Determination of the Kwall correction factor for a cylindrical ionization chamber to measure air-kerma in 60Co gamma beams.

PubMed

Laitano, R F; Toni, M P; Pimpinella, M; Bovi, M

2002-07-21

The factor Kwall to correct for photon attenuation and scatter in the wall of ionization chambers for 60Co air-kerma measurement has been traditionally determined by a procedure based on a linear extrapolation of the chamber current to zero wall thickness. Monte Carlo calculations by Rogers and Bielajew (1990 Phys. Med. Biol. 35 1065-78) provided evidence, mostly for chambers of cylindrical and spherical geometry, of appreciable deviations between the calculated values of Kwall and those obtained by the traditional extrapolation procedure. In the present work an experimental method other than the traditional extrapolation procedure was used to determine the Kwall factor. In this method the dependence of the ionization current in a cylindrical chamber was analysed as a function of an effective wall thickness in place of the physical (radial) wall thickness traditionally considered in this type of measurement. To this end the chamber wall was ideally divided into distinct regions and for each region an effective thickness to which the chamber current correlates was determined. A Monte Carlo calculation of attenuation and scatter effects in the different regions of the chamber wall was also made to compare calculation to measurement results. The Kwall values experimentally determined in this work agree within 0.2% with the Monte Carlo calculation. The agreement between these independent methods and the appreciable deviation (up to about 1%) between the results of both these methods and those obtained by the traditional extrapolation procedure support the conclusion that the two independent methods providing comparable results are correct and the traditional extrapolation procedure is likely to be wrong. The numerical results of the present study refer to a cylindrical cavity chamber like that adopted as the Italian national air-kerma standard at INMRI-ENEA (Italy). The method used in this study applies, however, to any other chamber of the same type.

Microwave measurements of temperature profiles, integrated water vapour, and liquid water path at Thule Air Base, Greenland.

NASA Astrophysics Data System (ADS)

Pace, Giandomenico; Di Iorio, Tatiana; di Sarra, Alcide; Iaccarino, Antonio; Meloni, Daniela; Mevi, Gabriele; Muscari, Giovanni; Cacciani, Marco

2017-04-01

A RPG Humidity And Temperature PROfiler (HATPRO-G2 ) radiometer was installed at Thule Air Base (76.5° N, 68.8° W), Greenland, in June 2016 in the framework of the Study of the water VApour in the polar AtmosPhere (SVAAP) project. The Danish Meteorological Institute started measurements of atmospheric properties at Thule Air Base in early '90s. The Thule High Arctic Atmospheric Observatory (THAAO) has grown in size and observing capabilities during the last three decades through the international effort of United States (NCAR and University of Alaska Fairbanks) and Italian (ENEA, INGV, University of Roma and Firenze) institutions (http://www.thuleatmos-it.it). Within this context, the intensive field campaign of the SVAAP project was aimed at the investigation of the surface radiation budget and took place from 5 to 28 July, 2016. After the summer campaign the HATPRO has continued to operate in order to monitor the annual variability of the temperature profile and integrated water vapour as well as the presence and characteristics of liquid clouds in the Artic environment. The combined use of the HATPRO together with other automatic instruments, such as a new microwave spectrometer (the water Vapour Emission Spectrometer for Polar Atmosphere VESPA-22), upward- and downward-looking pyranometers and pyrgeometers, a zenith-looking pyrometer operating in the 9.6-11.5 µm spectral range, an all sky camera, and a meteorological station, allows to investigate the clouds' physical and optical properties, as well as their impact on the surface radiation budget. This study will present and discuss the first few months of HATPRO observations; the effectiveness of the statistical retrieval used to derive the physical parameters from the HATPRO brightness temperatures will also be investigated through the comparison of the temperature and humidity profiles, and integrated water vapour, with data from radiosondes launched during the summer campaign and in winter time.

A graphite calorimeter for absolute measurements of absorbed dose to water: application in medium-energy x-ray filtered beams.

PubMed

Pinto, M; Pimpinella, M; Quini, M; D'Arienzo, M; Astefanoaei, I; Loreti, S; Guerra, A S

2016-02-21

The Italian National Institute of Ionizing Radiation Metrology (ENEA-INMRI) has designed and built a graphite calorimeter that, in a water phantom, has allowed the determination of the absorbed dose to water in medium-energy x-rays with generating voltages from 180 to 250 kV. The new standard is a miniaturized three-bodies calorimeter, with a disc-shaped core of 21 mm diameter and 2 mm thickness weighing 1.134 g, sealed in a PMMA waterproof envelope with air-evacuated gaps. The measured absorbed dose to graphite is converted into absorbed dose to water by means of an energy-dependent conversion factor obtained from Monte Carlo simulations. Heat-transfer correction factors were determined by FEM calculations. At a source-to-detector distance of 100 cm, a depth in water of 2 g cm(-2), and at a dose rate of about 0.15 Gy min(-1), results of calorimetric measurements of absorbed dose to water, D(w), were compared to experimental determinations, D wK, obtained via an ionization chamber calibrated in terms of air kerma, according to established dosimetry protocols. The combined standard uncertainty of D(w) and D(wK) were estimated as 1.9% and 1.7%, respectively. The two absorbed dose to water determinations were in agreement within 1%, well below the stated measurement uncertainties. Advancements are in progress to extend the measurement capability of the new in-water-phantom graphite calorimeter to other filtered medium-energy x-ray qualities and to reduce the D(w) uncertainty to around 1%. The new calorimeter represents the first implementation of in-water-phantom graphite calorimetry in the kilovoltage range and, allowing independent determinations of D(w), it will contribute to establish a robust system of absorbed dose to water primary standards for medium-energy x-ray beams.

Main natural hazards and vulnerability studies for some historical constructions and urban sectors of Valparaiso City (Chile)

NASA Astrophysics Data System (ADS)

Romanelli, F.

2009-04-01

The Project "MAR VASTO" ("Risk Management in Valparaíso/Manejo de Riesgos en Valparaíso, Servicios Técnicos", 2007) started in March 2007, with coordination of ENEA (Italian Agency for New Technologies, Energy and Environment), participation of several partners (Italy: University of Ferrara, Faculties of Architecture and Engineering; University of Padua, Faculty of Engineering; Abdus Salam International Centre for Theoretical Physics of Trieste; Chile: Valparaíso Technical University Federico Santa Maria, Civil Works Department; Santiago University of Chile, Division Structures Constructions Geotechnics), and support of local stakeholders. Being Valparaíso included since 2003 in the UNESCO Word Heritage List of protected sites, the project main goals are the following: to collect, analyze and elaborate the existing information, with a satisfying evaluation of main hazards; to develop a GIS digital archive, well organized, user-friendly and easy to be implemented in the future, providing maps and scenarios of specific and multiple risk; to provide a vulnerability analysis for three historical churches (San Francisco del Baron, Las Hermanitas de la Providencia, La Matríz, made by various materials - masonry, concrete, wood and adobe - and located in different city sites) and for a building stock in the Cerro Cordillera (partially inside the UNESCO area), analyzing more than 200 constructions; to suggest guidelines for future urban planning and strengthening interventions. In the framework of the MAR VASTO Project, the most important hazards have been investigated carried out. With regard to seismic hazard, "state-of-the-art" information has been provided by Chilean partners and stakeholders, using materials of several studies and stored in original earthquake reports, local newspapers and magazines. The activities performed by the Italian team regarded the definition, for the city of Valparaiso, of earthquake scenarios and maps based on the neo-deterministic approach. With regard to tsunami, the information has been provided by SHOA (Servicio Hidrografico y Oceanografico de la Armada de Chile). Tsunami scenarios and inundation maps (for both the 1906 and 1985 earthquakes) have been evaluated by the Italian team, taking into account also worse scenarios (namely the 1730 seismic event). Landslide hazard (identifying main flow areas and pointing out most affected zones, with a deeper investigation in the Cerro Cordillera, pilot area for the MAR VASTO Project) and fire hazard have been also evaluated. Finally, a GIS database has been developed, to store the hazard maps produced in the project. In addition, the GIS database has been verified by using the data obtained by a DGPS survey, performed during the in situ work in Valparaiso. In the framework of the MAR VASTO Project a building stock located in the Cerro Cordillera, partially inside the UNESCO area, has been investigated. The work done in the above said Cerro Cordillera sector by the Italian team can be considered a pilot experience which would be enlarged to all the Valparaiso City area in the framework of the town planning, actually in progress.

X-ray sterilization of insects and microorganisms for cultural heritage applications

NASA Astrophysics Data System (ADS)

Borgognoni, F.; Vadrucci, M.; Bazzano, G.; Ferrari, P.; Massa, S.; Moretti, R.; Calvitti, M.; Ronsivalle, C.; Moriani, A.; Picardi, L.

2017-09-01

The APAM (Development of Particle Accelerators and Medical Applications) Laboratory of the ENEA Frascati Research Center is engaged in the preservation of cultural heritage as part of the COBRA (Sviluppo e diffusione di metodi, tecnologie e strumenti avanzati per la COnservazione dei Beni culturali, basati sull'applicazione di Radiazioni e di tecnologie Abilitanti) project addressed to the transfer of innovative technologies and methodologies from research to small and medium enterprises involved in the restorative measures. This work aims to demonstrate the effectiveness of ionizing radiation on the disinfection of biodegraded art objects. The conventional methods for the disinfestation of works of art, using chemicals toxic to humans and environment, might cause some damage to the treated material even on micrometric scale (i. e. either cellulose degradation). Ionizing radiations interact with the infesting biological material causing an irreversible DNA degradation. For this reason, they are certainly suitable for removal treatments of both macro organisms and bacterial colonies. A 4.8 MeV electron linear accelerator, normally dedicated to the characterization of dose detectors and radiographies, has been employed to produce Bremsstrahlung X-rays through a lead converter. The spectral fluence of the radiation source has been calculated using the Monte Carlo MCNPX code. The dosimetric characterization of the radiation field has been made using radiochromic films sensitive in the dose range of our interest (from 50 to 500 Gy) calibrated with a Markus ionization chamber. The irradiation of the artifact prototypes are made within a lead shielded room at a variable distance from the X-rays source. Samples subjected to irradiation consist of a soil bacterium, Agrobacterium rhizogenes, and an insect, Stegobium paniceum, that are found as wall paintings invasive coloniser and as a pest of books, wood works and paintings, respectively. Tests of irradiation have been performed on pest organisms as well as on woods mock-ups to evaluate potential damage to the material during the sterilization. The growing capacity of the treated bacterial cells re-cultured at the end of the treatment was evaluated on the bacterial sample and resulted to strongly inhibit cell growth during post-irradiation incubation, so that after incubation periods at 28 °C, no significant cell growth was observed. The induced levels of insect mortality and sterility vs absorbed dose and operative conditions have been also evaluated, demonstrating the induction of full sterility since the lower dose and 40% mortality by two days after the higher dose treatment. The experiments proved the ability to efficaciously treat objects of cultural heritage with X-rays in order to prevent the increase of the biodeterioration without damaging the materials: in fact, mechanical tests on both irradiated and not irradiated woods have demonstrated the absence of any induced degradation after the radiation exposition.

Androgen and Progesterone Receptors Are Targets for Bisphenol A (BPA), 4-Methyl-2,4-bis-(P-Hydroxyphenyl)Pent-1-Ene--A Potent Metabolite of BPA, and 4-Tert-Octylphenol: A Computational Insight.

PubMed

Rehan, Mohd; Ahmad, Ejaz; Sheikh, Ishfaq A; Abuzenadah, Adel M; Damanhouri, Ghazi A; Bajouh, Osama S; AlBasri, Samera F; Assiri, Mansour M; Beg, Mohd A

2015-01-01

Exposure to toxic industrial chemicals that have capacity to disrupt the endocrine system, also known as endocrine disrupting chemicals (EDCs), has been increasingly associated with reproductive problems in human population. Bisphenol A (BPA; 4,4'-(propane-2,2-diyl)diphenol) and 4-tert-octylphenol (OP; 4-(1,1,3,3-tetramethylbutyl)phenol) are among the most common environmental contaminants possessing endocrine disruption properties and are present in plastics, epoxy resins, detergents and other commercial products of common personal and industrial use. A metabolite of BPA, 4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP) is about 1000 times more biologically active compared to BPA. Epidemiological, clinical, and experimental studies have shown association of BPA and OP with adverse effects on male and female reproductive system in human and animals. The endocrine disruption activity can occur through multiple pathways including binding to steroid receptors. Androgen receptor (AR) and progesterone receptor (PR) are critical for reproductive tract growth and function. Structural binding characterization of BPA, MBP, and OP with AR and PR using molecular docking simulation approaches revealed novel interactions of BPA with PR, and MBP and OP with AR and PR. For BPA, MBP, and OP, five AR interacting residues Leu-701, Leu-704, Asn-705, Met-742, and Phe-764 overlapped with those of native AR ligand testosterone, and four PR interacting residues Leu-715, Leu-718, Met-756, and Met-759 overlapped with those of PR co-complex ligand, norethindrone. For both the receptors the binding strength of MBP was maximum among the three compounds. Thus, these compounds have the potential to block or interfere in the binding of the endogenous native AR and PR ligands and, hence, resulting in dysfunction. The knowledge of the key interactions and the important amino-acid residues also allows better prediction of potential of xenobiotic molecules for disrupting AR- and PR-mediated pathways, thus, helping in design of less potent alternatives for commercial use.

Cognitive Assessment of Patients With Alzheimer's Disease by Telemedicine: Pilot Study.

PubMed

Carotenuto, Anna; Rea, Raffaele; Traini, Enea; Ricci, Giovanna; Fasanaro, Angiola Maria; Amenta, Francesco

2018-05-11

Approximately 46.8 million people are living with dementia worldwide and their number will grow in the next years. Any potential treatment should be administered as early as possible because it is important to provide an early cognitive assessment and to regularly monitor the mental function of patients. Information and communication technologies can be helpful to reach and follow patients without displacing them, but there may be doubts about the reliability of cognitive tests performed by telemedicine. The purpose of this study was to evaluate the reliability of the Mini Mental State Examination (MMSE) and the Alzheimer's Disease Assessment Scale cognitive subscale (ADAS-cog) tests administered in hospital by videoconference to patients with mild to moderate Alzheimer's disease. The tests were administered to 28 Alzheimer's disease outpatients (8 male, mean age 73.88, SD 7.45 years; 20 female mean age 76.00, SD 5.40 years) recruited and followed in the Alzheimer's Unit of the A Cardarelli National Hospital (Naples, Italy) at baseline and after 6, 12, 18, and 24 months of observation. Patients were evaluated first face-to-face by a psychologist and then, after 2 weeks, by another psychologist via videoconference in hospital. This study showed no differences in the MMSE and ADAS-cog scores when the tests were administered face-to-face or by videoconference, except in patients with more pronounced cognitive deficits (MMSE<17), in which the assessment via videoconference overestimated the cognitive impairment (face to face, MMSE mean 13.9, SD 4.9 and ADAS-cog mean 9.0, SD 3.8; videoconference, MMSE mean 42.8, SD 12.5 and ADAS-cog mean 56.9, SD 5.5). We found that videoconferencing is a reliable approach to document cognitive stability or decline, and to measure treatment effects in patients with mild to moderate dementia. A more extended study is needed to confirm these results. ©Anna Carotenuto, Raffaele Rea, Enea Traini, Giovanna Ricci, Angiola Maria Fasanaro, Francesco Amenta. Originally published in JMIR Mental Health (http://mental.jmir.org), 11.05.2018.

MATER - Pianeta Terra-Mare: an interactive and multidisciplinary approach to Geosphere sciences

NASA Astrophysics Data System (ADS)

Piangiamore, Giovanna Lucia; Fanelli, Emanuela; Furia, Stefania; Garau, Daniela; Merlino, Silvia; Musacchio, Gemma; Carla Centineo, Maria

2016-04-01

Recent studies demonstrate that Earth and Marine Sciences are not properly treated in scholastic programs and in textbooks are included in a superficial way. These topics are interdisciplinary and experimental (biology, ecology, oceanography and geology) and the recent advance in these fields is strictly linked to technologic improvement. School cannot keep up with the huge advances of knowledge experimented in the last 20 years, also for the lack of didactic laboratories sufficiently updated to support experimental activities. In this context, in 2014-15 three Italian Research Institutes (INGV, ISMAR-CNR and ENEA-CRAM) have decided to support the Unified School District "ISA 10"of Lerici (Liguria, Italy) - comprehensive of kindergartner, primary and middle schools - to develop the project MATER - Pianeta Terra-Mare (Planet Earth and Sea). The acronym MATER (MARe and TERra) has also a gender value, as people involved in the projects were women, mostly researchers and teachers, which have worked side by side with other women belonging to environmental and cultural associations of the territory. This heterogeneous group has a common objective: to promote the diffusion of a scientific culture and to sensitize students from 3 to 14 years towards problems occurring in marine and terrestrial environments, fostering the settlement of a sustainable attitude to the exploitation of natural resources and consciousness to natural hazards, such as earthquakes and floods, quite common in the Ligurian region. MATER has been considered as one of the best projects funded by MIUR (Italian Ministry of Education, University and Research) inside the Dissemination of Scientific and Technological Culture call for the year 2014. Natural hazards (Planet Earth) and the chemical-physical aspects and resources of the marine environment (Planet Sea) were the two modules of the project. Planet Earth developed through Piovono Idee! (Cloudy with a chance of Ideas!), an interactive exhibition on hydro-geological risk and climate change targeted to students from 8 to 14 years; Planet Sea was articulated in a series of laboratories on the physical-chemical properties ("a sustaining sea") and of the bio-ecological aspects ("a sea of resources") of the sea, engaging students from 4 to 14 years. Scientific conferences, targeted from teenagers and up and open to public, have been organized during the opening and closing weeks of the project, inside the "Week of Planet Earth" 2014 and 2015. The project was also a "peer-education experiment", where students of the High School "Pacinotti" (La Spezia) and of "ISA 10" (Lerici) and "ISA 2" (La Spezia) have played the role of guides in the interactive paths. MATER has reached ca. 1000 students and had excellent feedbacks from teachers and students, supported by questionnaires and press releases. Through the dedicated website, MATER is expected to reach a broader scholastic community, outside its local context. The project was a good example of cooperation of different territorial institutions/associations, working together to promote the culture of prevention and sustainability, involving future citizens to reflect on the values of appropriate behaviors and best practices towards an ethical and sustainable interaction between human activities with the geosphere.

Shaking Table Tests Validating Two Strengthening Interventions on Masonry Buildings

NASA Astrophysics Data System (ADS)

De Canio, Gerardo; Muscolino, Giuseppe; Palmeri, Alessandro; Poggi, Massimo; Clemente, Paolo

2008-07-01

Masonry buildings constitute quite often a precious cultural heritage for our cities. In order to future generations can enjoy this heritage, thence, effective projects of protection should be developed against all the anthropical and natural actions which may irreparably damage old masonry buildings. However, the strengthening interventions on these constructions have to respect their authenticity, without altering the original conception, not only functionally and aesthetically of course, but also statically. These issues are of central interests in the Messina area, where the seismic protection of new and existing constructions is a primary demand. It is well known, in fact, that the city of Messina lies in a highly seismic zone, and has been subjected to two destructive earthquakes in slightly more than one century, the 1783 Calabria earthquake and the more famous 1908 Messina-Reggio Calabria earthquake. It follows that the retrofitting projects on buildings which survived these two events should be designed with the aim to save the life of occupants operating with "light" techniques, i.e. respecting the original structural scheme. On the other hand, recent earthquakes, and in particular the 1997 Umbria-Marche sequence, unequivocally demonstrated that some of the most popular retrofitting interventions adopted in the second half the last century are absolutely ineffective, or even unsafe. Over these years, in fact, a number of "heavy" techniques proliferated, and therefore old masonry buildings suffered, among others, the substitution of existing timber slabs with more ponderous concrete slabs and/or the insertion of RC and steel members coupled with the original masonry elements (walls, arches, vaults). As a result, these buildings have been transformed by unwise engineers into hybrid structures, having a mixed behaviour (which frequently proved to be also unpredictable) between those of historic masonry and new members. Starting from these considerations, a numerical and experimental research has been carried out, aimed at validating two different strengthening interventions on masonry buildings: (i) the substitution of the existing roof with timber-concrete composite slabs, which are able to improve the dynamic behaviour of the structure without excessively increase the mass, and (ii) the reinforcement of masonry walls with FRP materials, which allow increasing both stiffness and strength of the construction. The experimental tests have been performed on a 1:2 scale model of a masonry building resembling a special type, the so-called "tipo misto messinese", which is proper to the reconstruction of the city of Messina after the 1783 Calabria earthquake. The model, incorporating a novel timber-concrete composite slab, has been tested on the main shaking table available at the ENEA Research Centre "Casaccia," both before and after the reinforcement with FRP materials. Some aspects related to the definition of the model and to the selection of an appropriate seismic input will be discussed, and numerical results confirming the effectiveness of the interventions mentioned above will be presented.

Shaking Table Tests Validating Two Strengthening Interventions on Masonry Buildings

DOE Office of Scientific and Technical Information (OSTI.GOV)

De Canio, Gerardo; Poggi, Massimo; Clemente, Paolo

2008-07-08

Masonry buildings constitute quite often a precious cultural heritage for our cities. In order to future generations can enjoy this heritage, thence, effective projects of protection should be developed against all the anthropical and natural actions which may irreparably damage old masonry buildings. However, the strengthening interventions on these constructions have to respect their authenticity, without altering the original conception, not only functionally and aesthetically of course, but also statically. These issues are of central interests in the Messina area, where the seismic protection of new and existing constructions is a primary demand. It is well known, in fact, thatmore » the city of Messina lies in a highly seismic zone, and has been subjected to two destructive earthquakes in slightly more than one century, the 1783 Calabria earthquake and the more famous 1908 Messina-Reggio Calabria earthquake. It follows that the retrofitting projects on buildings which survived these two events should be designed with the aim to save the life of occupants operating with 'light' techniques, i.e. respecting the original structural scheme. On the other hand, recent earthquakes, and in particular the 1997 Umbria-Marche sequence, unequivocally demonstrated that some of the most popular retrofitting interventions adopted in the second half the last century are absolutely ineffective, or even unsafe. Over these years, in fact, a number of 'heavy' techniques proliferated, and therefore old masonry buildings suffered, among others, the substitution of existing timber slabs with more ponderous concrete slabs and/or the insertion of RC and steel members coupled with the original masonry elements (walls, arches, vaults). As a result, these buildings have been transformed by unwise engineers into hybrid structures, having a mixed behaviour (which frequently proved to be also unpredictable) between those of historic masonry and new members. Starting from these considerations, a numerical and experimental research has been carried out, aimed at validating two different strengthening interventions on masonry buildings: (i) the substitution of the existing roof with timber-concrete composite slabs, which are able to improve the dynamic behaviour of the structure without excessively increase the mass, and (ii) the reinforcement of masonry walls with FRP materials, which allow increasing both stiffness and strength of the construction. The experimental tests have been performed on a 1:2 scale model of a masonry building resembling a special type, the so-called 'tipo misto messinese', which is proper to the reconstruction of the city of Messina after the 1783 Calabria earthquake. The model, incorporating a novel timber-concrete composite slab, has been tested on the main shaking table available at the ENEA Research Centre 'Casaccia', both before and after the reinforcement with FRP materials. Some aspects related to the definition of the model and to the selection of an appropriate seismic input will be discussed, and numerical results confirming the effectiveness of the interventions mentioned above will be presented.« less

Ocean data management in OMP Data Service

NASA Astrophysics Data System (ADS)

Fleury, Laurence; André, François; Belmahfoud, Nizar; Boichard, Jean-Luc; Brissebrat, Guillaume; Ferré, Hélène; Mière, Arnaud

2014-05-01

The Observatoire Midi-Pyrénées Data Service (SEDOO) is a development team, dedicated to environmental data management and dissemination application set up, in the framework of intensive field campaigns and long term observation networks. SEDOO developped some applications dealing with ocean data only, but also generic databases that enable to store and distribute multidisciplinary datasets. SEDOO is in charge of the in situ data management and the data portal for international and multidisciplinary programmes as large as African Monsoon Multidisciplinary Analyses (AMMA) and Mediterranean Integrated STudies at Regional And Local Scales (MISTRALS). The AMMA and MISTRALS databases are distributed and the data portals enable to access datasets managed by other data centres (IPSL, CORIOLIS...) through interoperability protocols (OPeNDAP, xml requests...). AMMA and MISTRALS metadata (data description) are standardized and comply with international standards (ISO 19115-19139; INSPIRE European Directive; Global Change Master Directory Thesaurus). Most of the AMMA and MISTRALS in situ ocean data sets are homogenized and inserted in a relational database, in order to enable accurate data selection and download of different data sets in a shared format. Data selection criteria are location, period, physical property name, physical property range... The data extraction procedure include format output selection among CSV, NetCDF, Nasa Ames... The AMMA database - http://database.amma-international.org/ - contains field campaign observations in the Guinea Gulf (EGEE 2005-2007) and Atlantic Tropical Ocean (AEROSE-II 2006...), as well as long term monitoring data (PIRATA, ARGO...). Operational analysis (MERCATOR) and satellite products (TMI, SSMI...) are managed by IPSL data centre and can be accessed too. They have been projected over regular latitude-longitude grids and converted into the NetCDF format. The MISTRALS data portal - http://mistrals.sedoo.fr/ - enables to access ocean datasets produced by the contributing programmes: Hydrological cycle in the Mediterranean eXperiment (HyMeX), Chemistry-Aerosol Mediterranean eXperiment (ChArMEx), Marine Mediterranean eXperiment (MERMeX)... The programmes include many field campaigns from 2011 to 2015, collecting general and specific properties. Long term monitoring networks, like Mediterranean Ocean Observing System on Environment (MOOSE) or Mediterranean Eurocentre for Underwater Sciences and Technologies (MEUST-SE), contribute to the MISTRALS data portal as well. Relevant model outputs and satellite products managed by external data centres (IPSL, ENEA...) can be accessed too. SEDOO manages the SSS (Sea Surface Salinity) national observation service data: http://sss.sedoo.fr/. SSS aims at collecting, validating, archiving and distributing in situ SSS measurements derived from Voluntary Observing Ship programs. The SSS data user interface enables to built multicriteria data request and download relevant datasets. SEDOO contributes to the SOLWARA project that aims at understanding the oceanic circulation in the Coral Sea and the Solomon Sea and their role in both the climate system and the oceanic chemistry. The research programme include in situ measurements, numerical modelling and compiled analyses of past data. The website http://thredds.sedoo.fr/solwara/ enables to access, visualize and download Solwara gridded data and model simulations, using Thredds associated services (OPEnDAP, NCSS and WMS). In order to improve the application user-friendliness, SSS and SOLWARA web interfaces are JEE applications build with GWT Framework, and share many modules.

Sexual and ethnic identity development among gay-bisexual-questioning (GBQ) male ethnic minority adolescents.

PubMed

Jamil, Omar B; Harper, Gary W; Fernandez, M Isabel

2009-07-01

Identity development is a critical task of adolescence and occurs across multiple areas of self-identification. Although research on the identity development process among individuals who are ethnic and sexual minorities has been conducted for individuals who have 1 minority status or the other, few studies have examined these processes in people who are both ethnic and sexual minorities. In this qualitative study, the authors examined the dual identity development processes related to ethnic and sexual identity among gay-bisexual-questioning (GBQ) Latino and African American male adolescents. Results indicated that the processes associated with the development of sexual orientation and ethnic identity occur concurrently. However, the actual processes involved with the development of each identity not only differed, but seemed to be independent of each other because neither process was referenced in the development of the other. Overall, the process of ethnic identity development involved the process of becoming aware of one's ethnic and cultural heritage, whereas sexual identity development involved finding one's own personally relevant sexual orientation label and connecting to that community. The implications of these findings for the development of interventions to assist in the healthy development of GBQ adolescents are discussed.

Sexual and Ethnic Identity Development among Gay/Bisexual/Questioning (GBQ) Male Ethnic Minority Adolescents

PubMed Central

Jamil, Omar B.; Harper, Gary W.; Fernandez, M. Isabel

2010-01-01

Identity development is a critical task of adolescence and occurs across multiple areas of self identification. Though research on the identity development process among individuals who are ethnic and sexual minorities has been conducted for individuals who have one minority status or the other, few studies have examined these processes in persons who are both ethnic and sexual minorities. This qualitative study examined the dual identity development processes related to ethnic and sexual identity among gay/bisexual/questioning (GBQ) Latino and African American male adolescents. Results indicated that the processes associated with the development of sexual orientation and ethnic identity occur concurrently. However, the actual processes involved with the development of each identity not only differed, but seemed to be independent of each other since neither process was referenced in the development of the other. Overall, the process of ethnic identity development involved the process of becoming aware of one’s ethnic and cultural heritage, while sexual identity development involved finding one’s own personally relevant sexual orientation label and connecting to that community. The implications of these findings for the development of interventions to assist in the healthy development of GBQ adolescents are discussed. PMID:19594249

Process Correlation Analysis Model for Process Improvement Identification

PubMed Central

Park, Sooyong

2014-01-01

Software process improvement aims at improving the development process of software systems. It is initiated by process assessment identifying strengths and weaknesses and based on the findings, improvement plans are developed. In general, a process reference model (e.g., CMMI) is used throughout the process of software process improvement as the base. CMMI defines a set of process areas involved in software development and what to be carried out in process areas in terms of goals and practices. Process areas and their elements (goals and practices) are often correlated due to the iterative nature of software development process. However, in the current practice, correlations of process elements are often overlooked in the development of an improvement plan, which diminishes the efficiency of the plan. This is mainly attributed to significant efforts and the lack of required expertise. In this paper, we present a process correlation analysis model that helps identify correlations of process elements from the results of process assessment. This model is defined based on CMMI and empirical data of improvement practices. We evaluate the model using industrial data. PMID:24977170

Process correlation analysis model for process improvement identification.

PubMed

Choi, Su-jin; Kim, Dae-Kyoo; Park, Sooyong

2014-01-01

Software process improvement aims at improving the development process of software systems. It is initiated by process assessment identifying strengths and weaknesses and based on the findings, improvement plans are developed. In general, a process reference model (e.g., CMMI) is used throughout the process of software process improvement as the base. CMMI defines a set of process areas involved in software development and what to be carried out in process areas in terms of goals and practices. Process areas and their elements (goals and practices) are often correlated due to the iterative nature of software development process. However, in the current practice, correlations of process elements are often overlooked in the development of an improvement plan, which diminishes the efficiency of the plan. This is mainly attributed to significant efforts and the lack of required expertise. In this paper, we present a process correlation analysis model that helps identify correlations of process elements from the results of process assessment. This model is defined based on CMMI and empirical data of improvement practices. We evaluate the model using industrial data.

Development and demonstration of manufacturing processes for fabricating graphite/LARC 160 polyimide structural elements

NASA Technical Reports Server (NTRS)

Frost, R. K.; Jones, J. S.; Dynes, P. J.; Wykes, D. H.

1981-01-01

The development and demonstration of manufacturing technologies for the structural application of Celion graphite/LARC-160 polyimide composite material is discussed. Process development and fabrication of demonstration components are discussed. Process development included establishing quality assurance of the basic composite material and processing, nondestructive inspection of fabricated components, developing processes for specific structural forms, and qualification of processes through mechanical testing. Demonstration components were fabricated. The demonstration components consisted of flat laminates, skin/stringer panels, honeycomb panels, chopped fiber compression moldings, and a technology demonstrator segment (TDS) representative of the space shuttle aft body flap.

Optimum processing of mammographic film.

PubMed

Sprawls, P; Kitts, E L

1996-03-01

Underprocessing of mammographic film can result in reduced contrast and visibility of breast structures and an unnecessary increase in radiation dose to the patient. Underprocessing can be caused by physical factors (low developer temperature, inadequate development time, insufficient developer agitation) or chemical factors (developer not optimized for film type; overdiluted, underreplenished, contaminated, or frequently changed developer). Conventional quality control programs are designed to produce consistent processing but do not address the issue of optimum processing. Optimum processing is defined as the level of processing that produces the film performance characteristics (contrast and sensitivity) specified by the film manufacturer. Optimum processing of mammographic film can be achieved by following a two-step protocol. The first step is to set up the processing conditions according to recommendations from the film and developer chemistry manufacturers. The second step is to verify the processing results by comparing them with sensitometric data provided by the film manufacturer.

78 FR 47012 - Developing Software Life Cycle Processes Used in Safety Systems of Nuclear Power Plants

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-02

... NUCLEAR REGULATORY COMMISSION [NRC-2012-0195] Developing Software Life Cycle Processes Used in... revised regulatory guide (RG), revision 1 of RG 1.173, ``Developing Software Life Cycle Processes for... Developing a Software Project Life Cycle Process,'' issued 2006, with the clarifications and exceptions as...

A Software Development Simulation Model of a Spiral Process

NASA Technical Reports Server (NTRS)

Mizell, Carolyn; Malone, Linda

2007-01-01

There is a need for simulation models of software development processes other than the waterfall because processes such as spiral development are becoming more and more popular. The use of a spiral process can make the inherently difficult job of cost and schedule estimation even more challenging due to its evolutionary nature, but this allows for a more flexible process that can better meet customers' needs. This paper will present a discrete event simulation model of spiral development that can be used to analyze cost and schedule effects of using such a process in comparison to a waterfall process.

Building a Training and Development Program.

ERIC Educational Resources Information Center

Bare, Alan C.

An approach to building an effective training and development (T&D) process within postsecondary institutions is described. The process involves three distinct phases: developing an inservice skills training program, institutionalizing an on-the-job career development process, and conducting organizational development activities. The focus of the…

Developments in Signature Process Control

NASA Astrophysics Data System (ADS)

Keller, L. B.; Dominski, Marty

1993-01-01

Developments in the adaptive process control technique known as Signature Process Control for Advanced Composites (SPCC) are described. This computer control method for autoclave processing of composites was used to develop an optimum cure cycle for AFR 700B polyamide and for an experimental poly-isoimide. An improved process cycle was developed for Avimid N polyamide. The potential for extending the SPCC technique to pre-preg quality control, press modeling, pultrusion and RTM is briefly discussed.

A Dual-Process Account of the Development of Scientific Reasoning: The Nature and Development of Metacognitive Intercession Skills

ERIC Educational Resources Information Center

Amsel, Eric; Klaczynski, Paul A.; Johnston, Adam; Bench, Shane; Close, Jason; Sadler, Eric; Walker, Rick

2008-01-01

Metacognitive knowledge of the dual-processing basis of judgment is critical to resolving conflict between analytic and experiential processing responses [Klaczynski, P. A. (2004). A dual-process model of adolescent development: Implications for decision making, reasoning, and identity. In R. V. Kail (Ed.), "Advances in child development and…

Technology and development requirements for advanced coal conversion systems

NASA Technical Reports Server (NTRS)

1981-01-01

A compendium of coal conversion process descriptions is presented. The SRS and MC data bases were utilized to provide information paticularly in the areas of existing process designs and process evaluations. Additional information requirements were established and arrangements were made to visit process developers, pilot plants, and process development units to obtain information that was not otherwise available. Plant designs, process descriptions and operating conditions, and performance characteristics were analyzed and requirements for further development identified and evaluated to determine the impact of these requirements on the process commercialization potential from the standpoint of economics and technical feasibility. A preliminary methodology was established for the comparative technical and economic assessment of advanced processes.

76 FR 19100 - Maria Carmen Palazzo: Debarment Order

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-06

... development or approval, including the process for development or approval, of any drug product or otherwise... development or approval, including the process for development or approval, of any drug product or otherwise... approval, including the process for development or approval, of any drug product and otherwise relating to...

An Implicit Model Development Process for Bounding External, Seemingly Intangible/Non-Quantifiable Factors

DTIC Science & Technology

2017-06-01

This research expands the modeling and simulation (M and S) body of knowledge through the development of an Implicit Model Development Process (IMDP...When augmented to traditional Model Development Processes (MDP), the IMDP enables the development of models that can address a broader array of...where a broader, more holistic approach of defining a models referent is achieved. Next, the IMDP codifies the process for implementing the improved model

Technological Improvements for Digital Fire Control Systems

DTIC Science & Technology

2017-09-30

Final Technical Status Report For DOTC-12-01-INIT061 Technological Improvements for Digital Fire Control Systems Reporting Period: 30 Sep...Initiative Information Develop and fabricate next generation designs using advanced materials and processes. This will include but is not limited to...4.2 Develop manufacturing processes 100% 4.3 Develop manufacturing processes 100% 4.4 Develop manufacturing processes 100% 5 Design Tooling

Business Development Process

DTIC Science & Technology

2001-10-31

832-4736. DISTRIBUTION STATEMENT A Approved for Public Release Distribution Unlimited Attorney Docket No. 83042 BUSINESS DEVELOPMENT PROCESS TO... BUSINESS DEVELOPMENT PROCESS 3 4 STATEMENT OF GOVERNMENT INTEREST 5 The invention described herein may be manufactured and used 6 by or for the...INVENTION 11 (1) Field of the Invention 12 This invention generally relates to a business 13 development process for assessing new business ideas

24 CFR 1003.304 - Funding process.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 4 2012-04-01 2012-04-01 false Funding process. 1003.304 Section 1003.304 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED... Application and Selection Process § 1003.304 Funding process. (a) Notification. Area ONAPs will notify...

24 CFR 1003.304 - Funding process.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 4 2011-04-01 2011-04-01 false Funding process. 1003.304 Section 1003.304 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED... Application and Selection Process § 1003.304 Funding process. (a) Notification. Area ONAPs will notify...

24 CFR 1003.304 - Funding process.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 4 2014-04-01 2014-04-01 false Funding process. 1003.304 Section 1003.304 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED... Application and Selection Process § 1003.304 Funding process. (a) Notification. Area ONAPs will notify...

24 CFR 1003.304 - Funding process.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 4 2013-04-01 2013-04-01 false Funding process. 1003.304 Section 1003.304 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED... Application and Selection Process § 1003.304 Funding process. (a) Notification. Area ONAPs will notify...

24 CFR 1003.304 - Funding process.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Funding process. 1003.304 Section 1003.304 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... Application and Selection Process § 1003.304 Funding process. (a) Notification. Area ONAPs will notify...

Flat-plate solar array project. Volume 5: Process development

NASA Technical Reports Server (NTRS)

Gallagher, B.; Alexander, P.; Burger, D.

1986-01-01

The goal of the Process Development Area, as part of the Flat-Plate Solar Array (FSA) Project, was to develop and demonstrate solar cell fabrication and module assembly process technologies required to meet the cost, lifetime, production capacity, and performance goals of the FSA Project. R&D efforts expended by Government, Industry, and Universities in developing processes capable of meeting the projects goals during volume production conditions are summarized. The cost goals allocated for processing were demonstrated by small volume quantities that were extrapolated by cost analysis to large volume production. To provide proper focus and coverage of the process development effort, four separate technology sections are discussed: surface preparation, junction formation, metallization, and module assembly.

Investigation of the Relationship Between Sensory Processing and Motor Development in Preterm Infants.

PubMed

Celik, Halil Ibrahim; Elbasan, Bulent; Gucuyener, Kivilcim; Kayihan, Hulya; Huri, Meral

The aim of this study was to analyze the correlation between sensory processing and motor development in preterm infants. We included 30 preterm and 30 term infants with corrected and chronological ages between 10 and 12 mo. We used the Test of Sensory Functions in Infants to evaluate sensory processing and the Alberta Infant Motor Scale to evaluate motor development. The Spearman correlation test indicated a strong positive relationship between sensory processing and motor development in preterm infants (r = .63, p < .001). Given the relationship between sensory processing and motor development in the preterm group, the evaluation of sensory processing and motor development in preterm infants was considered necessary for the effective implementation of physiotherapy assessment and interventions. Copyright © 2018 by the American Occupational Therapy Association, Inc.

ASRM test report: Autoclave cure process development

NASA Technical Reports Server (NTRS)

Nachbar, D. L.; Mitchell, Suzanne

1992-01-01

ASRM insulated segments will be autoclave cured following insulation pre-form installation and strip wind operations. Following competitive bidding, Aerojet ASRM Division (AAD) Purchase Order 100142 was awarded to American Fuel Cell and Coated Fabrics Company, Inc. (Amfuel), Magnolia, AR, for subcontracted insulation autoclave cure process development. Autoclave cure process development test requirements were included in Task 3 of TM05514, Manufacturing Process Development Specification for Integrated Insulation Characterization and Stripwind Process Development. The test objective was to establish autoclave cure process parameters for ASRM insulated segments. Six tasks were completed to: (1) evaluate cure parameters that control acceptable vulcanization of ASRM Kevlar-filled EPDM insulation material; (2) identify first and second order impact parameters on the autoclave cure process; and (3) evaluate insulation material flow-out characteristics to support pre-form configuration design.

Life cycle analysis within pharmaceutical process optimization and intensification: case study of active pharmaceutical ingredient production.

PubMed

Ott, Denise; Kralisch, Dana; Denčić, Ivana; Hessel, Volker; Laribi, Yosra; Perrichon, Philippe D; Berguerand, Charline; Kiwi-Minsker, Lioubov; Loeb, Patrick

2014-12-01

As the demand for new drugs is rising, the pharmaceutical industry faces the quest of shortening development time, and thus, reducing the time to market. Environmental aspects typically still play a minor role within the early phase of process development. Nevertheless, it is highly promising to rethink, redesign, and optimize process strategies as early as possible in active pharmaceutical ingredient (API) process development, rather than later at the stage of already established processes. The study presented herein deals with a holistic life-cycle-based process optimization and intensification of a pharmaceutical production process targeting a low-volume, high-value API. Striving for process intensification by transfer from batch to continuous processing, as well as an alternative catalytic system, different process options are evaluated with regard to their environmental impact to identify bottlenecks and improvement potentials for further process development activities. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

SOI-CMOS Process for Monolithic, Radiation-Tolerant, Science-Grade Imagers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Williams, George; Lee, Adam

In Phase I, Voxtel worked with Jazz and Sandia to document and simulate the processes necessary to implement a DH-BSI SOI CMOS imaging process. The development is based upon mature SOI CMOS process at both fabs, with the addition of only a few custom processing steps for integration and electrical interconnection of the fully-depleted photodetectors. In Phase I, Voxtel also characterized the Sandia process, including the CMOS7 design rules, and we developed the outline of a process option that included a “BOX etch”, that will permit a “detector in handle” SOI CMOS process to be developed The process flows weremore » developed in cooperation with both Jazz and Sandia process engineers, along with detailed TCAD modeling and testing of the photodiode array architectures. In addition, Voxtel tested the radiation performance of the Jazz’s CA18HJ process, using standard and circular-enclosed transistors.« less

Processes of Personality Development in Adulthood: The TESSERA Framework.

PubMed

Wrzus, Cornelia; Roberts, Brent W

2017-08-01

The current article presents a theoretical framework of the short- and long-term processes underlying personality development throughout adulthood. The newly developed TESSERA framework posits that long-term personality development occurs due to repeated short-term, situational processes. These short-term processes can be generalized as recursive sequence of Triggering situations, Expectancy, States/State expressions, and Reactions (TESSERA). Reflective and associative processes on TESSERA sequences can lead to personality development (i.e., continuity and lasting changes in explicit and implicit personality characteristics and behavioral patterns). We illustrate how the TESSERA framework facilitates a more comprehensive understanding of normative and differential personality development at various ages during the life span. The TESSERA framework extends previous theories by explicitly linking short- and long-term processes of personality development, by addressing different manifestations of personality, and by being applicable to different personality characteristics, for example, behavioral traits, motivational orientations, or life narratives.

Achieving continuous manufacturing for final dosage formation: challenges and how to meet them. May 20-21, 2014 Continuous Manufacturing Symposium.

PubMed

Byrn, Stephen; Futran, Maricio; Thomas, Hayden; Jayjock, Eric; Maron, Nicola; Meyer, Robert F; Myerson, Allan S; Thien, Michael P; Trout, Bernhardt L

2015-03-01

We describe the key issues and possibilities for continuous final dosage formation, otherwise known as downstream processing or drug product manufacturing. A distinction is made between heterogeneous processing and homogeneous processing, the latter of which is expected to add more value to continuous manufacturing. We also give the key motivations for moving to continuous manufacturing, some of the exciting new technologies, and the barriers to implementation of continuous manufacturing. Continuous processing of heterogeneous blends is the natural first step in converting existing batch processes to continuous. In heterogeneous processing, there are discrete particles that can segregate, versus in homogeneous processing, components are blended and homogenized such that they do not segregate. Heterogeneous processing can incorporate technologies that are closer to existing technologies, where homogeneous processing necessitates the development and incorporation of new technologies. Homogeneous processing has the greatest potential for reaping the full rewards of continuous manufacturing, but it takes long-term vision and a more significant change in process development than heterogeneous processing. Heterogeneous processing has the detriment that, as the technologies are adopted rather than developed, there is a strong tendency to incorporate correction steps, what we call below "The Rube Goldberg Problem." Thus, although heterogeneous processing will likely play a major role in the near-term transformation of heterogeneous to continuous processing, it is expected that homogeneous processing is the next step that will follow. Specific action items for industry leaders are: Form precompetitive partnerships, including industry (pharmaceutical companies and equipment manufacturers), government, and universities. These precompetitive partnerships would develop case studies of continuous manufacturing and ideally perform joint-technology development, including development of small-scale equipment and processes. Develop ways to invest internally in continuous manufacturing. How best to do this will depend on the specifics of a given organization, in particular the current development projects. Upper managers will need to energize their process developers to incorporate continuous manufacturing in at least part of their processes to gain experience and demonstrate directly the benefits. Training of continuous manufacturing technologies, organizational approaches, and regulatory approaches is a key area that industrial leaders should pursue together. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.

Improving Video Game Development: Facilitating Heterogeneous Team Collaboration through Flexible Software Processes

NASA Astrophysics Data System (ADS)

Musil, Juergen; Schweda, Angelika; Winkler, Dietmar; Biffl, Stefan

Based on our observations of Austrian video game software development (VGSD) practices we identified a lack of systematic processes/method support and inefficient collaboration between various involved disciplines, i.e. engineers and artists. VGSD includes heterogeneous disciplines, e.g. creative arts, game/content design, and software. Nevertheless, improving team collaboration and process support is an ongoing challenge to enable a comprehensive view on game development projects. Lessons learned from software engineering practices can help game developers to increase game development processes within a heterogeneous environment. Based on a state of the practice survey in the Austrian games industry, this paper presents (a) first results with focus on process/method support and (b) suggests a candidate flexible process approach based on Scrum to improve VGSD and team collaboration. Results showed (a) a trend to highly flexible software processes involving various disciplines and (b) identified the suggested flexible process approach as feasible and useful for project application.

A Prototype for the Support of Integrated Software Process Development and Improvement

NASA Astrophysics Data System (ADS)

Porrawatpreyakorn, Nalinpat; Quirchmayr, Gerald; Chutimaskul, Wichian

An efficient software development process is one of key success factors for quality software. Not only can the appropriate establishment but also the continuous improvement of integrated project management and of the software development process result in efficiency. This paper hence proposes a software process maintenance framework which consists of two core components: an integrated PMBOK-Scrum model describing how to establish a comprehensive set of project management and software engineering processes and a software development maturity model advocating software process improvement. Besides, a prototype tool to support the framework is introduced.

Model for Simulating a Spiral Software-Development Process

NASA Technical Reports Server (NTRS)

Mizell, Carolyn; Curley, Charles; Nayak, Umanath

2010-01-01

A discrete-event simulation model, and a computer program that implements the model, have been developed as means of analyzing a spiral software-development process. This model can be tailored to specific development environments for use by software project managers in making quantitative cases for deciding among different software-development processes, courses of action, and cost estimates. A spiral process can be contrasted with a waterfall process, which is a traditional process that consists of a sequence of activities that include analysis of requirements, design, coding, testing, and support. A spiral process is an iterative process that can be regarded as a repeating modified waterfall process. Each iteration includes assessment of risk, analysis of requirements, design, coding, testing, delivery, and evaluation. A key difference between a spiral and a waterfall process is that a spiral process can accommodate changes in requirements at each iteration, whereas in a waterfall process, requirements are considered to be fixed from the beginning and, therefore, a waterfall process is not flexible enough for some projects, especially those in which requirements are not known at the beginning or may change during development. For a given project, a spiral process may cost more and take more time than does a waterfall process, but may better satisfy a customer's expectations and needs. Models for simulating various waterfall processes have been developed previously, but until now, there have been no models for simulating spiral processes. The present spiral-process-simulating model and the software that implements it were developed by extending a discrete-event simulation process model of the IEEE 12207 Software Development Process, which was built using commercially available software known as the Process Analysis Tradeoff Tool (PATT). Typical inputs to PATT models include industry-average values of product size (expressed as number of lines of code), productivity (number of lines of code per hour), and number of defects per source line of code. The user provides the number of resources, the overall percent of effort that should be allocated to each process step, and the number of desired staff members for each step. The output of PATT includes the size of the product, a measure of effort, a measure of rework effort, the duration of the entire process, and the numbers of injected, detected, and corrected defects as well as a number of other interesting features. In the development of the present model, steps were added to the IEEE 12207 waterfall process, and this model and its implementing software were made to run repeatedly through the sequence of steps, each repetition representing an iteration in a spiral process. Because the IEEE 12207 model is founded on a waterfall paradigm, it enables direct comparison of spiral and waterfall processes. The model can be used throughout a software-development project to analyze the project as more information becomes available. For instance, data from early iterations can be used as inputs to the model, and the model can be used to estimate the time and cost of carrying the project to completion.

77 FR 17460 - Multistakeholder Process To Develop Consumer Data Privacy Codes of Conduct

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-26

.... 120214135-2203-02] RIN 0660-XA27 Multistakeholder Process To Develop Consumer Data Privacy Codes of Conduct... request for public comments on the multistakeholder process to develop consumer data privacy codes of...-multistakeholder-process without change. All personal identifying information (for example, name, address...

77 FR 50724 - Developing Software Life Cycle Processes for Digital Computer Software Used in Safety Systems of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-22

... NUCLEAR REGULATORY COMMISSION [NRC-2012-0195] Developing Software Life Cycle Processes for Digital... Software Life Cycle Processes for Digital Computer Software used in Safety Systems of Nuclear Power Plants... clarifications, the enhanced consensus practices for developing software life-cycle processes for digital...

An intraorganizational model for developing and spreading quality improvement innovations.

PubMed

Kellogg, Katherine C; Gainer, Lindsay A; Allen, Adrienne S; OʼSullivan, Tatum; Singer, Sara J

Recent policy reforms encourage quality improvement (QI) innovations in primary care, but practitioners lack clear guidance regarding spread inside organizations. We designed this study to identify how large organizations can facilitate intraorganizational spread of QI innovations. We conducted ethnographic observation and interviews in a large, multispecialty, community-based medical group that implemented three QI innovations across 10 primary care sites using a new method for intraorganizational process development and spread. We compared quantitative outcomes achieved through the group's traditional versus new method, created a process model describing the steps in the new method, and identified barriers and facilitators at each step. The medical group achieved substantial improvement using its new method of intraorganizational process development and spread of QI innovations: standard work for rooming and depression screening, vaccine error rates and order compliance, and Pap smear error rates. Our model details nine critical steps for successful intraorganizational process development (set priorities, assess the current state, develop the new process, and measure and refine) and spread (develop support, disseminate information, facilitate peer-to-peer training, reinforce, and learn and adapt). Our results highlight the importance of utilizing preexisting organizational structures such as established communication channels, standardized roles, common workflows, formal authority, and performance measurement and feedback systems when developing and spreading QI processes inside an organization. In particular, we detail how formal process advocate positions in each site for each role can facilitate the spread of new processes. Successful intraorganizational spread is possible and sustainable. Developing and spreading new QI processes across sites inside an organization requires creating a shared understanding of the necessary process steps, considering the barriers that may arise at each step, and leveraging preexisting organizational structures to facilitate intraorganizational process development and spread.

An intraorganizational model for developing and spreading quality improvement innovations

PubMed Central

Kellogg, Katherine C.; Gainer, Lindsay A.; Allen, Adrienne S.; O'Sullivan, Tatum; Singer, Sara J.

2017-01-01

Background: Recent policy reforms encourage quality improvement (QI) innovations in primary care, but practitioners lack clear guidance regarding spread inside organizations. Purpose: We designed this study to identify how large organizations can facilitate intraorganizational spread of QI innovations. Methodology/Approach: We conducted ethnographic observation and interviews in a large, multispecialty, community-based medical group that implemented three QI innovations across 10 primary care sites using a new method for intraorganizational process development and spread. We compared quantitative outcomes achieved through the group’s traditional versus new method, created a process model describing the steps in the new method, and identified barriers and facilitators at each step. Findings: The medical group achieved substantial improvement using its new method of intraorganizational process development and spread of QI innovations: standard work for rooming and depression screening, vaccine error rates and order compliance, and Pap smear error rates. Our model details nine critical steps for successful intraorganizational process development (set priorities, assess the current state, develop the new process, and measure and refine) and spread (develop support, disseminate information, facilitate peer-to-peer training, reinforce, and learn and adapt). Our results highlight the importance of utilizing preexisting organizational structures such as established communication channels, standardized roles, common workflows, formal authority, and performance measurement and feedback systems when developing and spreading QI processes inside an organization. In particular, we detail how formal process advocate positions in each site for each role can facilitate the spread of new processes. Practice Implications: Successful intraorganizational spread is possible and sustainable. Developing and spreading new QI processes across sites inside an organization requires creating a shared understanding of the necessary process steps, considering the barriers that may arise at each step, and leveraging preexisting organizational structures to facilitate intraorganizational process development and spread. PMID:27428788

Integrated approaches to the application of advanced modeling technology in process development and optimization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Allgor, R.J.; Feehery, W.F.; Tolsma, J.E.

The batch process development problem serves as good candidate to guide the development of process modeling environments. It demonstrates that very robust numerical techniques are required within an environment that can collect, organize, and maintain the data and models required to address the batch process development problem. This paper focuses on improving the robustness and efficiency of the numerical algorithms required in such a modeling environment through the development of hybrid numerical and symbolic strategies.

Developing Worksheet (LKS) Base on Process Skills in Curriculum 2013 at Elementary School Grade IV,V,VI

NASA Astrophysics Data System (ADS)

Subhan, M.; Oktolita, N.; Kn, M.

2018-04-01

The Lacks of students' skills in the learning process is due to lacks of exercises in the form of LKS. In the curriculum of 2013, there is no LKS as a companion to improve the students' skills. In order to solve those problem, it is necessary to develop LKS based on process skills as a teaching material to improve students' process skills. The purpose of this study is to develop LKS Process Skills based elementary school grade IV, V, VI which is integrated by process skill. The development of LKS can be used to develop the thematic process skills of elementary school students grade IV, V, VI based on curriculum 2013. The expected long-term goal is to produce teaching materials LKS Process Skill based of Thematic learning that is able to develop the process skill of elementary school students grade IV, V, VI. This development research refers to the steps developed by Borg & Gall (1983). The development process is carried out through 10 stages: preliminary research and gathering information, planning, draft development, initial test (limited trial), first product revision, final trial (field trial), product operational revision, Desemination and implementation. The limited subject of the this research is the students of SDN in Dharmasraya grade IV, V, VI. The field trial subjects in the experimental class are the students of SDN Dharmasraya grade IV, V, VI who have implemented the curriculum 2013. The data are collected by using LKS validation sheets, process skill observation sheets, and Thematic learning test (pre-test And post-test). The result of LKS development on the validity score is 81.70 (very valid), on practical score is 83.94 (very practical), and on effectiveness score is 86.67 (very effective). In the trial step the use of LKS using One Group Pretest-Posttest Design research design. The purpose of this trial is to know the effectiveness level of LKS result of development for improving the process skill of students in grade IV, V, and VI of elementary school. The data collection in this research uses the test result sheet of the process skill through pre-test and post-test. Observation results were analyzed with SPSS 16.0 software. The Result of analysis learning process of student skill of Sig value. (2-tailed) (0,000) <α (0.005) then H0 is rejected. There is a significant difference to the development of process skills between students using LKS with students who do not use LKS. It can be concluded that LKS have accuracy, ease and can improve result learn on aspect of skill process of student of grade IV, V and VI elementary school.

Distillate fuel-oil processing for phosphoric acid fuel cell power plants

NASA Astrophysics Data System (ADS)

1980-02-01

Efforts to develop distillate oil steam reforming processes are reviewed, and the applicability of these processes for integration with the fuel cell are discussed. The development efforts can be grouped into the following processing approaches: high temperature steam reforming; autothermal reforming; autothermal gasification; and ultra desulfurization followed by steam reforming. Sulfur in the feed is a problem in the process development.

Development of environmentally conscious cleaning process for leadless chip carrier assemblies. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adams, B.E.

1995-04-01

A cross-functional team of process, product, quality, material, and design lab engineers was assembled to develop an environmentally friendly cleaning process for leadless chip carrier assemblies (LCCAs). Using flush and filter testing, Auger surface analysis, GC-Mass spectrophotometry, production yield results, and electrical testing results over an extended testing period, the team developed an aqueous cleaning process for LCCAs. The aqueous process replaced the Freon vapor degreasing/ultrasonic rinse process.

A Process Research Framework: The International Process Research Consortium

DTIC Science & Technology

2006-12-01

projects ? 52 Theme P | IPRC Framework 5 P-30 How should a process for collaborative development be formulated? The development at different companies...requires some process for the actual collaboration . How should it be handled? P-31 How do we handle change? Requirements change during development ...source projects employ a single-site development model in which there is no large community of testers but rather a single-site small group

Drug Development Process

MedlinePlus

... Home Food Drugs Medical Devices Radiation-Emitting Products Vaccines, Blood & Biologics Animal & Veterinary Cosmetics Tobacco Products For Patients Home For Patients Learn About Drug and Device Approvals The Drug Development Process The Drug Development Process Share Tweet Linkedin Pin ...

A Petri Net-Based Software Process Model for Developing Process-Oriented Information Systems

NASA Astrophysics Data System (ADS)

Li, Yu; Oberweis, Andreas

Aiming at increasing flexibility, efficiency, effectiveness, and transparency of information processing and resource deployment in organizations to ensure customer satisfaction and high quality of products and services, process-oriented information systems (POIS) represent a promising realization form of computerized business information systems. Due to the complexity of POIS, explicit and specialized software process models are required to guide POIS development. In this chapter we characterize POIS with an architecture framework and present a Petri net-based software process model tailored for POIS development with consideration of organizational roles. As integrated parts of the software process model, we also introduce XML nets, a variant of high-level Petri nets as basic methodology for business processes modeling, and an XML net-based software toolset providing comprehensive functionalities for POIS development.

Developing Elementary Math and Science Process Skills Through Engineering Design Instruction

NASA Astrophysics Data System (ADS)

Strong, Matthew G.

This paper examines how elementary students can develop math and science process skills through an engineering design approach to instruction. The performance and development of individual process skills overall and by gender were also examined. The study, preceded by a pilot, took place in a grade four extracurricular engineering design program in a public, suburban school district. Students worked in pairs and small groups to design and construct airplane models from styrofoam, paper clips, and toothpicks. The development and performance of process skills were assessed through a student survey of learning gains, an engineering design packet rubric (student work), observation field notes, and focus group notes. The results indicate that students can significantly develop process skills, that female students may develop process skills through engineering design better than male students, and that engineering design is most helpful for developing the measuring, suggesting improvements, and observing process skills. The study suggests that a more regular engineering design program or curriculum could be beneficial for students' math and science abilities both in this school and for the elementary field as a whole.

Thread, Web and Tapestry-making: Processes of Development and Language.

ERIC Educational Resources Information Center

Robinson, Clinton D. W.

1999-01-01

Reviews the major features of participatory development, asking how far similar processes are applied in promoting the use of local languages. Argues that language development processes must figure into participatory approaches to develop multilingual environments and that attention to language must proceed along similar participatory lines. (CMK)

Introduction of male circumcision for HIV prevention in Uganda: analysis of the policy process.

PubMed

Odoch, Walter Denis; Kabali, Kenneth; Ankunda, Racheal; Zulu, Joseph Mumba; Tetui, Moses

2015-06-20

Health policy analysis is important for all health policies especially in fields with ever changing evidence-based interventions such as HIV prevention. However, there are few published reports of health policy analysis in sub-Saharan Africa in this field. This study explored the policy process of the introduction of male circumcision (MC) for HIV prevention in Uganda in order to inform the development processes of similar health policies. Desk review of relevant documents was conducted between March and May 2012. Thematic analysis was used to analyse the data. Conceptual frameworks that demonstrate the interrelationship within the policy development processes and influence of actors in the policy development processes guided the analysis. Following the introduction of MC on the national policy agenda in 2007, negotiation and policy formulation preceded its communication and implementation. Policy proponents included academic researchers in the early 2000s and development partners around 2007. Favourable contextual factors that supported the development of the policy included the rising HIV prevalence, adoption of MC for HIV prevention in other sub-Saharan African countries, and expertise on MC. Additionally, the networking capability of proponents facilitated the change in position of non-supportive or neutral actors. Non-supportive and neutral actors in the initial stages of the policy development process included the Ministry of Health, traditional and Muslim leaders, and the Republican President. Using political authority, legitimacy, and charisma, actors who opposed the policy tried to block the policy development process. Researchers' initial disregard of the Ministry of Health in the research process of MC and the missing civil society advocacy arm contributed to delays in the policy development process. This study underscores the importance of securing top political leadership as well as key implementing partners' support in policy development processes. Equally important is the appreciation of the various forms of actors' power and how such power shapes the policy agenda, development process, and content.

Analysis of complex decisionmaking processes. [with application to jet engine development

NASA Technical Reports Server (NTRS)

Hill, J. D.; Ollila, R. G.

1978-01-01

The analysis of corporate decisionmaking processes related to major system developments is unusually difficult because of the number of decisionmakers involved in the process and the long development cycle. A method for analyzing such decision processes is developed and illustrated through its application to the analysis of the commercial jet engine development process. The method uses interaction matrices as the key tool for structuring the problem, recording data, and analyzing the data to establish the rank order of the major factors affecting development decisions. In the example, the use of interaction matrices permitted analysts to collect and analyze approximately 50 factors that influenced decisions during the four phases of the development cycle, and to determine the key influencers of decisions at each development phase. The results of this study indicate that the cost of new technology installed on an aircraft is the prime concern of the engine manufacturer.

Engaged for Change: A Community-Engaged Process for Developing Interventions to Reduce Health Disparities.

PubMed

Rhodes, Scott D; Mann-Jackson, Lilli; Alonzo, Jorge; Simán, Florence M; Vissman, Aaron T; Nall, Jennifer; Abraham, Claire; Aronson, Robert E; Tanner, Amanda E

2017-12-01

The science underlying the development of individual, community, system, and policy interventions designed to reduce health disparities has lagged behind other innovations. Few models, theoretical frameworks, or processes exist to guide intervention development. Our community-engaged research partnership has been developing, implementing, and evaluating efficacious interventions to reduce HIV disparities for over 15 years. Based on our intervention research experiences, we propose a novel 13-step process designed to demystify and guide intervention development. Our intervention development process includes steps such as establishing an intervention team to manage the details of intervention development; assessing community needs, priorities, and assets; generating intervention priorities; evaluating and incorporating theory; developing a conceptual or logic model; crafting activities; honing materials; administering a pilot, noting its process, and gathering feedback from all those involved; and editing the intervention based on what was learned. Here, we outline and describe each of these 13 steps.

Developing a practice guideline for the occupational health services by using a community of practice approach: a process evaluation of the development process.

PubMed

Kwak, Lydia; Wåhlin, Charlotte; Stigmar, Kjerstin; Jensen, Irene

2017-01-18

One way to facilitate the translation of research into the occupational health service practice is through clinical practice guidelines. To increase the implementability of guidelines it is important to include the end-users in the development, for example by a community of practice approach. This paper describes the development of an occupational health practice guideline aimed at the management of non-specific low back pain (LBP) by using a community of practice approach. The paper also includes a process evaluation of the development providing insight into the feasibility of the process. A multidisciplinary community of practice group (n = 16) consisting of occupational nurses, occupational physicians, ergonomists/physical therapists, health and safety engineers, health educators, psychologists and researchers from different types of occupational health services and geographical regions within Sweden met eleven times (June 2012-December 2013) to develop the practice guideline following recommendations of guideline development handbooks. Process-outcomes recruitment, reach, context, satisfaction, feasibility and fidelity were assessed by questionnaire, observations and administrative data. Group members attended on average 7.5 out of 11 meetings. Half experienced support from their workplace for their involvement. Feasibility was rated as good, except for time-scheduling. Most group members were satisfied with the structure of the process (e.g. presentations, multidisciplinary group). Fidelity was rated as fairly high. The described development process is a feasible process for guideline development. For future guideline development expectations of the work involved should be more clearly communicated, as well as the purpose and tasks of the CoP-group. Moreover, possibilities to improve support from managers and colleagues should be explored. This paper has important implications for future guideline development; it provides valuable information on how practitioners can be included in the development process, with the aim of increasing the implementability of the developed guidelines.

Dimpled ball grid array process development for space flight applications

NASA Technical Reports Server (NTRS)

Barr, S. L.; Mehta, A.

2000-01-01

A 472 dimpled ball grid array (D-BGA) package has not been used in past space flight environments, therefore it was necessary to develop a process that would yield robust and reliable solder joints. The process developing assembly, inspection and rework techniques, were verified by conducting environmental tests. Since the 472 D-BGA packages passed the above environmental tests within the specifications, the process was successfully developed for space flight electronics.

Review of Exploration Systems Development (ESD) Integrated Hazard Development Process. Volume 1; Appendices

NASA Technical Reports Server (NTRS)

Smiles, Michael D.; Blythe, Michael P.; Bejmuk, Bohdan; Currie, Nancy J.; Doremus, Robert C.; Franzo, Jennifer C.; Gordon, Mark W.; Johnson, Tracy D.; Kowaleski, Mark M.; Laube, Jeffrey R.

2015-01-01

The Chief Engineer of the Exploration Systems Development (ESD) Office requested that the NASA Engineering and Safety Center (NESC) perform an independent assessment of the ESD's integrated hazard development process. The focus of the assessment was to review the integrated hazard analysis (IHA) process and identify any gaps/improvements in the process (e.g., missed causes, cause tree completeness, missed hazards). This document contains the outcome of the NESC assessment.

Review of Exploration Systems Development (ESD) Integrated Hazard Development Process. Appendices; Volume 2

NASA Technical Reports Server (NTRS)

Smiles, Michael D.; Blythe, Michael P.; Bejmuk, Bohdan; Currie, Nancy J.; Doremus, Robert C.; Franzo, Jennifer C.; Gordon, Mark W.; Johnson, Tracy D.; Kowaleski, Mark M.; Laube, Jeffrey R.

2015-01-01

The Chief Engineer of the Exploration Systems Development (ESD) Office requested that the NASA Engineering and Safety Center (NESC) perform an independent assessment of the ESD's integrated hazard development process. The focus of the assessment was to review the integrated hazard analysis (IHA) process and identify any gaps/improvements in the process (e.g. missed causes, cause tree completeness, missed hazards). This document contains the outcome of the NESC assessment.

Technology development for lunar base water recycling

NASA Technical Reports Server (NTRS)

Schultz, John R.; Sauer, Richard L.

1992-01-01

This paper will review previous and ongoing work in aerospace water recycling and identify research activities required to support development of a lunar base. The development of a water recycle system for use in the life support systems envisioned for a lunar base will require considerable research work. A review of previous work on aerospace water recycle systems indicates that more efficient physical and chemical processes are needed to reduce expendable and power requirements. Development work on biological processes that can be applied to microgravity and lunar environments also needs to be initiated. Biological processes are inherently more efficient than physical and chemical processes and may be used to minimize resupply and waste disposal requirements. Processes for recovering and recycling nutrients such as nitrogen, phosphorus, and sulfur also need to be developed to support plant growth units. The development of efficient water quality monitors to be used for process control and environmental monitoring also needs to be initiated.

Data Processing and First Products from the Hyperspectral Imager for the Coastal Ocean (HICO) on the International Space Station

DTIC Science & Technology

2010-04-01

NRL Stennis Space Center (NRL-SSC) for further processing using the NRL SSC Automated Processing System (APS). APS was developed for processing...have not previously developed automated processing for 73 hyperspectral ocean color data. The hyperspectral processing branch includes several

The Importance of Process-Oriented Accessibility Guidelines for Web Developers.

PubMed

Steen-Hansen, Linn; Fagernes, Siri

2016-01-01

Current accessibility research shows that in the web development, the process itself may lead to inaccessible web sites and applications. Common practices typically do not allow sufficient testing. The focus is mainly on complying with minimum standards, and treating accessibility compliance as a sort of bug-fixing process, missing the user perspective. In addition, there is an alarming lack of knowledge and experience with accessibility issues. It has also been argued that bringing accessibility into the development process at all stages is the only way to achieve the highest possible level of accessibility. The work presented in this paper is based on a previous project focusing on guidelines for developing accessible rich Internet applications. The guidelines were classified as either process-oriented or technology-oriented. In this paper, we examine the process-oriented guidelines and give a practical perspective on how these guidelines will make the development process more accessibility-friendly.

Automated Array Assembly, Phase 2

NASA Technical Reports Server (NTRS)

Carbajal, B. G.

1979-01-01

The solar cell module process development activities in the areas of surface preparation are presented. The process step development was carried out on texture etching including the evolution of a conceptual process model for the texturing process; plasma etching; and diffusion studies that focused on doped polymer diffusion sources. Cell processing was carried out to test process steps and a simplified diode solar cell process was developed. Cell processing was also run to fabricate square cells to populate sample minimodules. Module fabrication featured the demonstration of a porcelainized steel glass structure that should exceed the 20 year life goal of the low cost silicon array program. High efficiency cell development was carried out in the development of the tandem junction cell and a modification of the TJC called the front surface field cell. Cell efficiencies in excess of 16 percent at AM1 have been attained with only modest fill factors. The transistor-like model was proposed that fits the cell performance and provides a guideline for future improvements in cell performance.

Developing Cultural Literacy through the Writing Process: Empowering All Learners.

ERIC Educational Resources Information Center

Palmer, Barbara C.; And Others

Combining the expansion of cultural literacy with the development of process-based writing, this book addresses each stage of the writing process, with emphasis on the recursive and overlapping nature of these stages. Numerous related model activities at the end of each chapter show how to develop the writing process, while expanding the writer's…

Development and efficiency assessment of process lubrication for hot forging

NASA Astrophysics Data System (ADS)

Kargin, S.; Artyukh, Viktor; Ignatovich, I.; Dikareva, Varvara

2017-10-01

The article considers innovative technologies in testing and production of process lubricants for hot bulk forging. There were developed new compositions of eco-friendly water-graphite process lubricants for hot extrusion and forging. New approaches to efficiency assessment of process lubricants are developed and described in the following article. Laboratory and field results are presented.

77 FR 56646 - Wayne E. Spencer: Debarment Order

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-13

..., including the process for development or approval, of a drug product under the FD&C Act. Dr. Spencer was..., including the process for development or approval, of a drug product under the FD&C Act. On March 7, 2012... to the development or approval, including the process for development or approval, of a drug product...

Matthew Oliver | NREL

Science.gov Websites

Process Development Unit. NREL's Thermal and Catalytic Process Development Unit can process 1/2 ton per biomass to fuels and chemicals Affiliated Research Programs Thermochemical Process Integration, Scale-Up

Large-scale production of diesel-like biofuels - process design as an inherent part of microorganism development.

PubMed

Cuellar, Maria C; Heijnen, Joseph J; van der Wielen, Luuk A M

2013-06-01

Industrial biotechnology is playing an important role in the transition to a bio-based economy. Currently, however, industrial implementation is still modest, despite the advances made in microorganism development. Given that the fuels and commodity chemicals sectors are characterized by tight economic margins, we propose to address overall process design and efficiency at the start of bioprocess development. While current microorganism development is targeted at product formation and product yield, addressing process design at the start of bioprocess development means that microorganism selection can also be extended to other critical targets for process technology and process scale implementation, such as enhancing cell separation or increasing cell robustness at operating conditions that favor the overall process. In this paper we follow this approach for the microbial production of diesel-like biofuels. We review current microbial routes with both oleaginous and engineered microorganisms. For the routes leading to extracellular production, we identify the process conditions for large scale operation. The process conditions identified are finally translated to microorganism development targets. We show that microorganism development should be directed at anaerobic production, increasing robustness at extreme process conditions and tailoring cell surface properties. All the same time, novel process configurations integrating fermentation and product recovery, cell reuse and low-cost technologies for product separation are mandatory. This review provides a state-of-the-art summary of the latest challenges in large-scale production of diesel-like biofuels. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Exploring the Role of Usability in the Software Process: A Study of Irish Software SMEs

NASA Astrophysics Data System (ADS)

O'Connor, Rory V.

This paper explores the software processes and usability techniques used by Small and Medium Enterprises (SMEs) that develop web applications. The significance of this research is that it looks at development processes used by SMEs in order to assess to what degree usability is integrated into the process. This study seeks to gain an understanding into the level of awareness of usability within SMEs today and their commitment to usability in practice. The motivation for this research is to explore the current development processes used by SMEs in developing web applications and to understand how usability is represented in those processes. The background for this research is provided by the growth of the web application industry beyond informational web sites to more sophisticated applications delivering a broad range of functionality. This paper presents an analysis of the practices of several Irish SMEs that develop web applications through a series of case studies. With the focus on SMEs that develop web applications as Management Information Systems and not E-Commerce sites, informational sites, online communities or web portals. This study gathered data about the usability techniques practiced by these companies and their awareness of usability in the context of the software process in those SMEs. The contribution of this study is to further the understanding of the current role of usability within the software development processes of SMEs that develop web applications.

An assessment of space shuttle flight software development processes

NASA Technical Reports Server (NTRS)

1993-01-01

In early 1991, the National Aeronautics and Space Administration's (NASA's) Office of Space Flight commissioned the Aeronautics and Space Engineering Board (ASEB) of the National Research Council (NRC) to investigate the adequacy of the current process by which NASA develops and verifies changes and updates to the Space Shuttle flight software. The Committee for Review of Oversight Mechanisms for Space Shuttle Flight Software Processes was convened in Jan. 1992 to accomplish the following tasks: (1) review the entire flight software development process from the initial requirements definition phase to final implementation, including object code build and final machine loading; (2) review and critique NASA's independent verification and validation process and mechanisms, including NASA's established software development and testing standards; (3) determine the acceptability and adequacy of the complete flight software development process, including the embedded validation and verification processes through comparison with (1) generally accepted industry practices, and (2) generally accepted Department of Defense and/or other government practices (comparing NASA's program with organizations and projects having similar volumes of software development, software maturity, complexity, criticality, lines of code, and national standards); (4) consider whether independent verification and validation should continue. An overview of the study, independent verification and validation of critical software, and the Space Shuttle flight software development process are addressed. Findings and recommendations are presented.

A conceptual model for the development process of confirmatory adaptive clinical trials within an emergency research network.

PubMed

Mawocha, Samkeliso C; Fetters, Michael D; Legocki, Laurie J; Guetterman, Timothy C; Frederiksen, Shirley; Barsan, William G; Lewis, Roger J; Berry, Donald A; Meurer, William J

2017-06-01

Adaptive clinical trials use accumulating data from enrolled subjects to alter trial conduct in pre-specified ways based on quantitative decision rules. In this research, we sought to characterize the perspectives of key stakeholders during the development process of confirmatory-phase adaptive clinical trials within an emergency clinical trials network and to build a model to guide future development of adaptive clinical trials. We used an ethnographic, qualitative approach to evaluate key stakeholders' views about the adaptive clinical trial development process. Stakeholders participated in a series of multidisciplinary meetings during the development of five adaptive clinical trials and completed a Strengths-Weaknesses-Opportunities-Threats questionnaire. In the analysis, we elucidated overarching themes across the stakeholders' responses to develop a conceptual model. Four major overarching themes emerged during the analysis of stakeholders' responses to questioning: the perceived statistical complexity of adaptive clinical trials and the roles of collaboration, communication, and time during the development process. Frequent and open communication and collaboration were viewed by stakeholders as critical during the development process, as were the careful management of time and logistical issues related to the complexity of planning adaptive clinical trials. The Adaptive Design Development Model illustrates how statistical complexity, time, communication, and collaboration are moderating factors in the adaptive design development process. The intensity and iterative nature of this process underscores the need for funding mechanisms for the development of novel trial proposals in academic settings.

Flood replenishment: a new method of processor control.

PubMed

Frank, E D; Gray, J E; Wilken, D A

1980-01-01

In mechanized radiographic film processors that process medium to low volumes of film, roll films, and those that process single-emulsion films from nuclear medicine scans, computed tomography, and ultrasound, it is difficult to maintain the developer solution at a stable processing level. We describe our experience using flood replenishment, which is a method in which developer replenisher containing starter solution is introduced in the processor at timed intervals, independent of the number of films being processed. By this process, a stable level of developer activity is maintained in a processor used to develop a medium to low volume of single-emulsion film.

Spacelab Data Processing Facility (SLDPF) quality assurance expert systems development

NASA Technical Reports Server (NTRS)

Basile, Lisa R.; Kelly, Angelita C.

1987-01-01

The Spacelab Data Processing Facility (SLDPF) is an integral part of the Space Shuttle data network for missions that involve attached scientific payloads. Expert system prototypes were developed to aid in the performance of the quality assurance function of the Spacelab and/or Attached Shuttle Payloads processed telemetry data. The Spacelab Input Processing System (SIPS) and the Spacelab Output Processing System (SOPS), two expert systems, were developed to determine their feasibility and potential in the quality assurance of processed telemetry data. The capabilities and performance of these systems are discussed.

Is There Room for "Development" in Developmental Models of Information Processing Biases to Threat in Children and Adolescents?

ERIC Educational Resources Information Center

Field, Andy P.; Lester, Kathryn J.

2010-01-01

Clinical and experimental theories assume that processing biases in attention and interpretation are a causal mechanism through which anxiety develops. Despite growing evidence that these processing biases are present in children and, therefore, develop long before adulthood, these theories ignore the potential role of child development. This…

Implementing a Process to Measure Return on Investment for Nursing Professional Development.

PubMed

Garrison, Elisabeth; Beverage, Jodie

Return on investment (ROI) is one way to quantify the value that nursing professional development brings to the organization. This article describes a process to begin tracking ROI for nursing professional development. Implementing a process of tracking nursing professional development practitioners' ROI increased awareness of the financial impact and effectiveness of the department.

42 CFR 137.295 - May Self-Governance Tribes elect to develop their own environmental review process?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false May Self-Governance Tribes elect to develop their... SELF-GOVERNANCE Construction Nepa Process § 137.295 May Self-Governance Tribes elect to develop their own environmental review process? Yes, Self-Governance Tribes may develop their own environmental...

Facilitating Behavior Change with Low-Literacy Patient Education Materials

ERIC Educational Resources Information Center

Seligman, Hilary K.; Wallace, Andrea S.; DeWalt, Darren A.; Schillinger, Dean; Arnold, Connie L.; Shilliday, Betsy Bryant; Delgadillo, Adriana; Bengal, Nikki; Davis, Terry C.

2007-01-01

Objective: To describe a process for developing low-literacy health education materials that increase knowledge and activate patients toward healthier behaviors. Methods: We developed a theoretically informed process for developing educational materials. This process included convening a multidisciplinary creative team, soliciting stakeholder…

Some Evaluative Comments Based on a Review of the Curriculum Development Processes Operating in the Stanford Program on International and Cross Cultural Education. [and] A Review of the Curriculum. Development Processes Operating in the Stanford Program on International and Cross-Cultural Education.

ERIC Educational Resources Information Center

Kennedy, Kerry J.

The processes of instructional materials development and dissemination used in four Stanford Program on International and Cross Cultural Education (SPICE) projects dealing with Latin America, Africa, China, and Japan are described, and evaluative comments based on a review of the curriculum development process are made. The major purpose of the…

The Racial and Ethnic Identity Formation Process of Second-Generation Asian Indian Americans: A Phenomenological Study.

PubMed

Iwamoto, Derek Kenji; Negi, Nalini Junko; Partiali, Rachel Negar; Creswell, John W

2013-10-01

This phenomenological study elucidates the identity development processes of 12 second-generation adult Asian Indian Americans. The results identify salient sociocultural factors and multidimensional processes of racial and ethnic identity development. Discrimination, parental, and community factors seemed to play a salient role in influencing participants' racial and ethnic identity development. The emergent Asian Indian American racial and ethnic identity model provides a contextualized overview of key developmental periods and turning points within the process of identity development.

Virtual Collaborative Simulation Environment for Integrated Product and Process Development

NASA Technical Reports Server (NTRS)

Gulli, Michael A.

1997-01-01

Deneb Robotics is a leader in the development of commercially available, leading edge three- dimensional simulation software tools for virtual prototyping,, simulation-based design, manufacturing process simulation, and factory floor simulation and training applications. Deneb has developed and commercially released a preliminary Virtual Collaborative Engineering (VCE) capability for Integrated Product and Process Development (IPPD). This capability allows distributed, real-time visualization and evaluation of design concepts, manufacturing processes, and total factory and enterprises in one seamless simulation environment.

The Racial and Ethnic Identity Formation Process of Second-Generation Asian Indian Americans: A Phenomenological Study

PubMed Central

Iwamoto, Derek Kenji; Negi, Nalini Junko; Partiali, Rachel Negar; Creswell, John W.

2014-01-01

This phenomenological study elucidates the identity development processes of 12 second-generation adult Asian Indian Americans. The results identify salient sociocultural factors and multidimensional processes of racial and ethnic identity development. Discrimination, parental, and community factors seemed to play a salient role in influencing participants’ racial and ethnic identity development. The emergent Asian Indian American racial and ethnic identity model provides a contextualized overview of key developmental periods and turning points within the process of identity development. PMID:25298617

Self-Reacting Friction Stir Welding for Aluminum Complex Curvature Applications

NASA Technical Reports Server (NTRS)

Brown, Randy J.; Martin, W.; Schneider, J.; Hartley, P. J.; Russell, Carolyn; Lawless, Kirby; Jones, Chip

2003-01-01

This viewgraph representation provides an overview of sucessful research conducted by Lockheed Martin and NASA to develop an advanced self-reacting friction stir technology for complex curvature aluminum alloys. The research included weld process development for 0.320 inch Al 2219, sucessful transfer from the 'lab' scale to the production scale tool and weld quality exceeding strenght goals. This process will enable development and implementation of large scale complex geometry hardware fabrication. Topics covered include: weld process development, weld process transfer, and intermediate hardware fabrication.

Exploiting mAb structure characteristics for a directed QbD implementation in early process development.

PubMed

Karlberg, Micael; von Stosch, Moritz; Glassey, Jarka

2018-03-07

In today's biopharmaceutical industries, the lead time to develop and produce a new monoclonal antibody takes years before it can be launched commercially. The reasons lie in the complexity of the monoclonal antibodies and the need for high product quality to ensure clinical safety which has a significant impact on the process development time. Frameworks such as quality by design are becoming widely used by the pharmaceutical industries as they introduce a systematic approach for building quality into the product. However, full implementation of quality by design has still not been achieved due to attrition mainly from limited risk assessment of product properties as well as the large number of process factors affecting product quality that needs to be investigated during the process development. This has introduced a need for better methods and tools that can be used for early risk assessment and predictions of critical product properties and process factors to enhance process development and reduce costs. In this review, we investigate how the quantitative structure-activity relationships framework can be applied to an existing process development framework such as quality by design in order to increase product understanding based on the protein structure of monoclonal antibodies. Compared to quality by design, where the effect of process parameters on the drug product are explored, quantitative structure-activity relationships gives a reversed perspective which investigates how the protein structure can affect the performance in different unit operations. This provides valuable information that can be used during the early process development of new drug products where limited process understanding is available. Thus, quantitative structure-activity relationships methodology is explored and explained in detail and we investigate the means of directly linking the structural properties of monoclonal antibodies to process data. The resulting information as a decision tool can help to enhance the risk assessment to better aid process development and thereby overcome some of the limitations and challenges present in QbD implementation today.

[Contention on the theory of processing techniques of Chinese materia medica in the Ming-Qing period].

PubMed

Chen, Bin; Jia, Tianzhu

2015-03-01

On the basis of the golden stage of development of processing techniques of medicinals in the Song dynasty, the theory and techniques of processing in the Ming-Qing dynasties developed and accomplished further. The knowledge of some physicians on the processing of common medicinal, such as Radix rehmannia and Radixophiopogonis, was questioned, with new idea of processing methods put forward and argued against those insisting traditional ones, marking the progress of the art of processing. By reviewing the contention of technical theory of medicinal processing in the Ming-Qing period, useful references can be provided for the inheritance and development of the traditional art of processing medicinals.

A continuous process for the development of Kodak Aerochrome Infrared Film 2443 as a negative

NASA Astrophysics Data System (ADS)

Klimes, D.; Ross, D. I.

1993-02-01

A process for the continuous dry-to-dry development of Kodak Aerochrome Infrared Film 2443 as a negative (CIR-neg) is described. The process is well suited for production processing of long film lengths. Chemicals from three commercial film processes are used with modifications. Sensitometric procedures are recommended for the monitoring of processing quality control. Sensitometric data and operational aerial exposures indicate that films developed in this process have approximately the same effective aerial film speed as films processed in the reversal process recommended by the manufacturer (Kodak EA-5). The CIR-neg process is useful when aerial photography is acquired for resources management applications which require print reproductions. Originals can be readily reproduced using conventional production equipment (electronic dodging) in black and white or color (color compensation).

Digital Signal Processing Based Biotelemetry Receivers

NASA Technical Reports Server (NTRS)

Singh, Avtar; Hines, John; Somps, Chris

1997-01-01

This is an attempt to develop a biotelemetry receiver using digital signal processing technology and techniques. The receiver developed in this work is based on recovering signals that have been encoded using either Pulse Position Modulation (PPM) or Pulse Code Modulation (PCM) technique. A prototype has been developed using state-of-the-art digital signal processing technology. A Printed Circuit Board (PCB) is being developed based on the technique and technology described here. This board is intended to be used in the UCSF Fetal Monitoring system developed at NASA. The board is capable of handling a variety of PPM and PCM signals encoding signals such as ECG, temperature, and pressure. A signal processing program has also been developed to analyze the received ECG signal to determine heart rate. This system provides a base for using digital signal processing in biotelemetry receivers and other similar applications.

Pre- and Post-Processing Tools to Streamline the CFD Process

NASA Technical Reports Server (NTRS)

Dorney, Suzanne Miller

2002-01-01

This viewgraph presentation provides information on software development tools to facilitate the use of CFD (Computational Fluid Dynamics) codes. The specific CFD codes FDNS and CORSAIR are profiled, and uses for software development tools with these codes during pre-processing, interim-processing, and post-processing are explained.

Developing a Phonological Awareness Curriculum: Reflections on an Implementation Science Framework

ERIC Educational Resources Information Center

Goldstein, Howard; Olszewski, Arnold

2015-01-01

Purpose: This article describes the process of developing and implementing a supplemental early literacy curriculum designed for preschoolers demonstrating delays in literacy development. Method: Intervention research and implementation research have traditionally been viewed as sequential processes. This article illustrates a process of…

43 CFR 10005.17 - Plan development process.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Plan development process. 10005.17 Section 10005.17 Public Lands: Interior Regulations Relating to Public Lands (Continued) UTAH RECLAMATION...'S MITIGATION AND CONSERVATION PLAN § 10005.17 Plan development process. Following adoption of the...

40 CFR 35.613 - Competitive process.

Code of Federal Regulations, 2012 CFR

2012-07-01

... STATE AND LOCAL ASSISTANCE Environmental Program Grants for Tribes Wetlands Development Grant Program (section 104(b)(3)) § 35.613 Competitive process. Wetlands development grants are awarded on a competitive... process is complete, the recipient can, at its discretion, accept the award as a wetlands development...

40 CFR 35.613 - Competitive process.

Code of Federal Regulations, 2011 CFR

2011-07-01

... STATE AND LOCAL ASSISTANCE Environmental Program Grants for Tribes Wetlands Development Grant Program (section 104(b)(3)) § 35.613 Competitive process. Wetlands development grants are awarded on a competitive... process is complete, the recipient can, at its discretion, accept the award as a wetlands development...

40 CFR 35.613 - Competitive process.

Code of Federal Regulations, 2013 CFR

2013-07-01

... STATE AND LOCAL ASSISTANCE Environmental Program Grants for Tribes Wetlands Development Grant Program (section 104(b)(3)) § 35.613 Competitive process. Wetlands development grants are awarded on a competitive... process is complete, the recipient can, at its discretion, accept the award as a wetlands development...

Recent Developments in Advanced Automated Post-Processing at AMOS

DTIC Science & Technology

2014-09-01

Borelli KJS Consulting Lisa Thompson Air Force Research Laboratory ABSTRACT A new automated post-processing system has been developed to...the existing algorithms in addition to the development of new data processing features. 6. REFERENCES 1 Matson, C.L., Beckner, C.C., Borelli , K

Government Open Systems Interconnection Profile (GOSIP) Transition Strategy

DTIC Science & Technology

1993-09-01

it explores some of the GOSIP protocol details and discusses the process by which standards organizations have developed their...version 1 and 2. Additionally, it explores some of the GOSIP protocol details and discusses the process by which standards organizations have developed ...ORGANIZATION OF STUDY 1. The Standards Process Chapter II describes the process whereby standards are developed and adopted by the ISO and how the

Integration of utility and environmental activities in the project development process.

DOT National Transportation Integrated Search

2010-01-01

Two sources of delay during the project development process are utility adjustments and the environmental : review and clearance process. There are several efforts underway at the Texas Department of Transportation : (TxDOT) to optimize these process...

IMPROVING INDUSTRIAL WASTEWATER TREATMENT PROCESS RELIABILITY TO ENHANCE SUSTAINABLE DEVELOPMENT

EPA Science Inventory

Sustainable development includes the recovery of resources from industrial manufacturing processes. One valuable resource that can often be purified and reused is process wastewater. Typically, pollutants are removed from process wastewater using physical, chemical, and biologica...

A Decision Tool that Combines Discrete Event Software Process Models with System Dynamics Pieces for Software Development Cost Estimation and Analysis

NASA Technical Reports Server (NTRS)

Mizell, Carolyn Barrett; Malone, Linda

2007-01-01

The development process for a large software development project is very complex and dependent on many variables that are dynamic and interrelated. Factors such as size, productivity and defect injection rates will have substantial impact on the project in terms of cost and schedule. These factors can be affected by the intricacies of the process itself as well as human behavior because the process is very labor intensive. The complex nature of the development process can be investigated with software development process models that utilize discrete event simulation to analyze the effects of process changes. The organizational environment and its effects on the workforce can be analyzed with system dynamics that utilizes continuous simulation. Each has unique strengths and the benefits of both types can be exploited by combining a system dynamics model and a discrete event process model. This paper will demonstrate how the two types of models can be combined to investigate the impacts of human resource interactions on productivity and ultimately on cost and schedule.

Developing evidence-based physical therapy clinical practice guidelines.

PubMed

Kaplan, Sandra L; Coulter, Colleen; Fetters, Linda

2013-01-01

Recommended strategies for developing evidence-based clinical practice guidelines (CPGs) are provided. The intent is that future CPGs developed with the support of the Section on Pediatrics of the American Physical Therapy Association would consistently follow similar developmental processes to yield consistent quality and presentation. Steps in the process of developing CPGs are outlined and resources are provided to assist CPG developers in carrying out their task. These recommended processes may also be useful to CPG developers representing organizations with similar structures, objectives, and resources.

Development and demonstration of manufacturing processes for fabricating graphite/LARC-160 polyimide structural elements, part 4, paragraph B

NASA Technical Reports Server (NTRS)

1980-01-01

A quality assurance program was developed which included specifications for celion/LARC-160 polyimide materials and quality control of materials and processes. The effects of monomers and/or polymer variables and prepeg variables on the processibility of celion/LARC prepeg were included. Processes for fabricating laminates, honeycomb core panels, and chopped fiber moldings were developed. Specimens and conduct tests were fabricated to qualify the processes for fabrication of demonstration components.

Rehabilitation centers in change: participatory methods for managing redesign and renovation.

PubMed

Lahtinen, Marjaana; Nenonen, Suvi; Rasila, Heidi; Lehtelä, Jouni; Ruohomäki, Virpi; Reijula, Kari

2014-01-01

The aim of this article is to describe a set of participatory methods that we have either developed or modified for developing future work and service environments to better suit renewable rehabilitation processes. We discuss the methods in a larger framework of change process model and participatory design. Rehabilitation organizations are currently in transition; customer groups, financing, services, and the processes of rehabilitation centers are changing. The pressure for change challenges the centers to develop both their processes and facilities. There is a need for methods that support change management. Four participatory methods were developed: future workshop, change survey, multi-method assessment tool, and participatory design generator cards. They were tested and evaluated in three rehabilitation centers at the different phases of their change process. The developed methods were considered useful in creating a mutual understanding of the change goals between different stakeholders, providing a good picture of the work community's attitudes toward the change, forming an integrated overview of the built and perceived environment, inspiring new solutions, and supporting the management in steering the change process. The change process model described in this article serves as a practical framework that combined the viewpoints of organizational and facility development. However, participatory design continues to face challenges concerning communication between different stakeholders, and further development of the methods and processes is still needed. Intervention studies could provide data on the success factors that enhance the transformations in the rehabilitation sector. Design process, methodology, organizational transformation, planning, renovation.

An Ibm PC/AT-Based Image Acquisition And Processing System For Quantitative Image Analysis

NASA Astrophysics Data System (ADS)

Kim, Yongmin; Alexander, Thomas

1986-06-01

In recent years, a large number of applications have been developed for image processing systems in the area of biological imaging. We have already finished the development of a dedicated microcomputer-based image processing and analysis system for quantitative microscopy. The system's primary function has been to facilitate and ultimately automate quantitative image analysis tasks such as the measurement of cellular DNA contents. We have recognized from this development experience, and interaction with system users, biologists and technicians, that the increasingly widespread use of image processing systems, and the development and application of new techniques for utilizing the capabilities of such systems, would generate a need for some kind of inexpensive general purpose image acquisition and processing system specially tailored for the needs of the medical community. We are currently engaged in the development and testing of hardware and software for a fairly high-performance image processing computer system based on a popular personal computer. In this paper, we describe the design and development of this system. Biological image processing computer systems have now reached a level of hardware and software refinement where they could become convenient image analysis tools for biologists. The development of a general purpose image processing system for quantitative image analysis that is inexpensive, flexible, and easy-to-use represents a significant step towards making the microscopic digital image processing techniques more widely applicable not only in a research environment as a biologist's workstation, but also in clinical environments as a diagnostic tool.

Collaboration process for integrated social and health care strategy implementation.

PubMed

Korpela, Jukka; Elfvengren, Kalle; Kaarna, Tanja; Tepponen, Merja; Tuominen, Markku

2012-01-01

To present a collaboration process for creating a roadmap for the implementation of a strategy for integrated health and social care. The developed collaboration process includes multiple phases and uses electronic group decision support system technology (GDSS). A case study done in the South Karelia District of Social and Health Services in Finland during 2010-2011. An expert panel of 13 participants was used in the planning process of the strategy implementation. The participants were interviewed and observed during the case study. As a practical result, a roadmap for integrated health and social care strategy implementation has been developed. The strategic roadmap includes detailed plans of several projects which are needed for successful integration strategy implementation. As an academic result, a collaboration process to create such a roadmap has been developed. The collaboration process and technology seem to suit the planning process well. The participants of the meetings were satisfied with the collaboration process and the GDSS technology. The strategic roadmap was accepted by the participants, which indicates satisfaction with the developed process.

A neuroconstructivist model of past tense development and processing.

PubMed

Westermann, Gert; Ruh, Nicolas

2012-07-01

We present a neural network model of learning and processing the English past tense that is based on the notion that experience-dependent cortical development is a core aspect of cognitive development. During learning the model adds and removes units and connections to develop a task-specific final architecture. The model provides an integrated account of characteristic errors during learning the past tense, adult generalization to pseudoverbs, and dissociations between verbs observed after brain damage in aphasic patients. We put forward a theory of verb inflection in which a functional processing architecture develops through interactions between experience-dependent brain development and the structure of the environment, in this case, the statistical properties of verbs in the language. The outcome of this process is a structured processing system giving rise to graded dissociations between verbs that are easy and verbs that are hard to learn and process. In contrast to dual-mechanism accounts of inflection, we argue that describing dissociations as a dichotomy between regular and irregular verbs is a post hoc abstraction and is not linked to underlying processing mechanisms. We extend current single-mechanism accounts of inflection by highlighting the role of structural adaptation in development and in the formation of the adult processing system. In contrast to some single-mechanism accounts, we argue that the link between irregular inflection and verb semantics is not causal and that existing data can be explained on the basis of phonological representations alone. This work highlights the benefit of taking brain development seriously in theories of cognitive development. Copyright 2012 APA, all rights reserved.

Development of the Upgraded DC Brush Gear Motor for Spacebus Platforms

NASA Technical Reports Server (NTRS)

Berning, Robert H.; Viout, Olivier

2010-01-01

The obsolescence of materials and processes used in the manufacture of traditional DC brush gear motors has necessitated the development of an upgraded DC brush gear motor (UBGM). The current traditional DC brush gear motor (BGM) design was evaluated using Six-Sigma process to identify potential design and production process improvements. The development effort resulted in a qualified UBGM design which improved manufacturability and reduced production costs. Using Six-Sigma processes and incorporating lessons learned during the development process also improved motor performance for UBGM making it a more viable option for future use as a deployment mechanism in space flight applications.

Transforming nanomedicine manufacturing toward Quality by Design and microfluidics.

PubMed

Colombo, Stefano; Beck-Broichsitter, Moritz; Bøtker, Johan Peter; Malmsten, Martin; Rantanen, Jukka; Bohr, Adam

2018-04-05

Nanopharmaceuticals aim at translating the unique features of nano-scale materials into therapeutic products and consequently their development relies critically on the progression in manufacturing technology to allow scalable processes complying with process economy and quality assurance. The relatively high failure rate in translational nanopharmaceutical research and development, with respect to new products on the market, is at least partly due to immature bottom-up manufacturing development and resulting sub-optimal control of quality attributes in nanopharmaceuticals. Recently, quality-oriented manufacturing of pharmaceuticals has undergone an unprecedented change toward process and product development interaction. In this context, Quality by Design (QbD) aims to integrate product and process development resulting in an increased number of product applications to regulatory agencies and stronger proprietary defense strategies of process-based products. Although QbD can be applied to essentially any production approach, microfluidic production offers particular opportunities for QbD-based manufacturing of nanopharmaceuticals. Microfluidics provides unique design flexibility, process control and parameter predictability, and also offers ample opportunities for modular production setups, allowing process feedback for continuously operating production and process control. The present review aims at outlining emerging opportunities in the synergistic implementation of QbD strategies and microfluidic production in contemporary development and manufacturing of nanopharmaceuticals. In doing so, aspects of design and development, but also technology management, are reviewed, as is the strategic role of these tools for aligning nanopharmaceutical innovation, development, and advanced industrialization in the broader pharmaceutical field. Copyright © 2018 Elsevier B.V. All rights reserved.

Proposal for establishing structure and process in the development of implicit chiropractic standards of care and practice guidelines.

PubMed

Hansen, D T; Adams, A H; Meeker, W C; Phillips, R B

1992-09-01

With the advent of health care's "era of accountability", the chiropractic profession is now faced with generating implicit standards and guidelines for care or having it done for us by outside agencies. Already we see chiropractic groups in individual states and provinces being pressured into naive efforts of guideline development. Current knowledge and experience are available through recent health care literature that clearly defines the structure and process of guideline development and offers suggestions on how to measure outcomes of those processes. In addition, the United States Congress has directed a new federal agency to oversee this activity and monitor outcomes of quality improvement programs. The time has come for the chiropractic profession to define its exact role in health care delivery and develop implicit standards of care and practice guidelines. This sentinel effort should be managed by a commissioned body of empaneled experts that generally represent the academic and clinical chiropractic profession. A protocol for selection of these panelists and the panel chairperson needs to be developed and memorialized. Appropriate methodology (with definitions) needs to be developed for the process of standards/guideline development. Adherence to the accepted structure and process of guideline development will ensure the continuity of this dynamic process in the coming generations. This proposal offers a preliminary definition of the structure and process, including a "seed" policy statement and decision flow chart, specific to guideline development. Once the structure and process of guideline development for chiropractic are defined, the profession can then present this product to federal and state agencies, private sector health care purchasers, patient advocacy groups and other stakeholders of chiropractic care.(ABSTRACT TRUNCATED AT 250 WORDS)

High-power ultrasonic processing: Recent developments and prospective advances

NASA Astrophysics Data System (ADS)

Gallego-Juarez, Juan A.

2010-01-01

Although the application of ultrasonic energy to produce or to enhance a wide variety of processes have been explored since about the middle of the 20th century, only a reduced number of ultrasonic processes have been established at industrial level. However, during the last ten years the interest in ultrasonic processing has revived particularly in industrial sectors where the ultrasonic technology may represent a clean and efficient tool to improve classical existing processes or an innovation alternative for the development of new processes. Such seems to be the case of relevant sectors such as food industry, environment, pharmaceuticals and chemicals manufacture, machinery, mining, etc where power ultrasound is becoming an emerging technology for process development. The possible major problem in the application of high-intensity ultrasound on industrial processing is the design and development of efficient power ultrasonic systems (generators and reactors) capable of large scale successful operation specifically adapted to each individual process. In the area of ultrasonic processing in fluid media and more specifically in gases, the development of the steppedplate transducers and other power ge with extensive radiating surface has strongly contributed to the implementation at semi-industrial and industrial stage of several commercial applications, in sectors such as food and beverage industry (defoaming, drying, extraction, etc), environment (air cleaning, sludge filtration, etc...), machinery and process for manufacturing (textile washing, paint manufacture, etc). The development of different cavitational reactors for liquid treatment in continuous flow is helping to introduce into industry the wide potential of the area of sonochemistry. Processes such as water and effluent treatment, crystallization, soil remediation, etc have been already implemented at semi-industrial and/or industrial stage. Other single advances in sectors like mining or energy have also to be mentioned. The objective of this paper is to review some recent developments in ultrasonic processing to show the present situation and the prospective progresses of high-power ultrasonics as an innovative technology in many industrial sectors.

High-throughput process development: I. Process chromatography.

PubMed

Rathore, Anurag S; Bhambure, Rahul

2014-01-01

Chromatographic separation serves as "a workhorse" for downstream process development and plays a key role in removal of product-related, host cell-related, and process-related impurities. Complex and poorly characterized raw materials and feed material, low feed concentration, product instability, and poor mechanistic understanding of the processes are some of the critical challenges that are faced during development of a chromatographic step. Traditional process development is performed as trial-and-error-based evaluation and often leads to a suboptimal process. High-throughput process development (HTPD) platform involves an integration of miniaturization, automation, and parallelization and provides a systematic approach for time- and resource-efficient chromatography process development. Creation of such platforms requires integration of mechanistic knowledge of the process with various statistical tools for data analysis. The relevance of such a platform is high in view of the constraints with respect to time and resources that the biopharma industry faces today. This protocol describes the steps involved in performing HTPD of process chromatography step. It described operation of a commercially available device (PreDictor™ plates from GE Healthcare). This device is available in 96-well format with 2 or 6 μL well size. We also discuss the challenges that one faces when performing such experiments as well as possible solutions to alleviate them. Besides describing the operation of the device, the protocol also presents an approach for statistical analysis of the data that is gathered from such a platform. A case study involving use of the protocol for examining ion-exchange chromatography of granulocyte colony-stimulating factor (GCSF), a therapeutic product, is briefly discussed. This is intended to demonstrate the usefulness of this protocol in generating data that is representative of the data obtained at the traditional lab scale. The agreement in the data is indeed very significant (regression coefficient 0.93). We think that this protocol will be of significant value to those involved in performing high-throughput process development of process chromatography.

Biochemical Process Development and Integration | Bioenergy | NREL

Science.gov Websites

Process Development We develop and scale fermentation processes that produce fuels and chemicals from guide experimental designs. Our newly updated fermentation laboratory houses 38 bench-scale fermentors current projects cover the fermentation spectrum including anaerobic, micro-aerobic, aerobic, and gas-to

[Development and innovation of traditional Chinese medicine processing discipline and Chinese herbal pieces industry].

PubMed

Xiao, Yong-Qing; Li, Li; Liu, Ying; Ma, Yin-Lian; Yu, Ding-Rong

2016-01-01

To elucidate the key issues in the development and innovation of traditional Chinese medicine processing discipline and Chinese herbal pieces industry Chinese herbal pieces industry. According to the author's accumulated experience over years and demand of the development of the Chinese herbal pieces industry, the key issues in the development and innovation on the Chinese herbal pieces industry were summarized. According to the author, the traditional Chinese medicine processing discipline shall focus on a application basis research. The development of this discipline should be closely related to the development of Chinese herbal pieces. The traditional Chinese medicine processing discipline can be improved and its results can be transformed only if this discipline were correlated with the Chinese herbal pieces industry, matched with the development of the Chinese herbal pieces industry, and solved the problems in the development on the Chinese herbal pieces industry. The development of traditional Chinese medicine processing discipline and the Chinese herbal pieces industry also requires scientific researchers to make constant innovations, realize the specialty of the researches, and innovate based on inheritance. Copyright© by the Chinese Pharmaceutical Association.

The Hyperspectral Imager for the Coastal Ocean (HICO): Sensor and Data Processing Overview

DTIC Science & Technology

2010-01-20

backscattering coefficients, and others. Several of these software modules will be developed within the Automated Processing System (APS), a data... Automated Processing System (APS) NRL developed APS, which processes satellite data into ocean color data products. APS is a collection of methods...used for ocean color processing which provide the tools for the automated processing of satellite imagery [1]. These tools are in the process of

Transformation from manufacturing process taxonomy to repair process taxonomy: a phenetic approach

NASA Astrophysics Data System (ADS)

Raza, Umair; Ahmad, Wasim; Khan, Atif

2018-02-01

The need of taxonomy is vital for knowledge sharing. This need has been portrayed by through-life engineering services/systems. This paper addresses this issue by repair process taxonomy development. Framework for repair process taxonomy was developed followed by its implementation. The importance of repair process taxonomy has been highlighted.

Development of numerical processing in children with typical and dyscalculic arithmetic skills—a longitudinal study

PubMed Central

Landerl, Karin

2013-01-01

Numerical processing has been demonstrated to be closely associated with arithmetic skills, however, our knowledge on the development of the relevant cognitive mechanisms is limited. The present longitudinal study investigated the developmental trajectories of numerical processing in 42 children with age-adequate arithmetic development and 41 children with dyscalculia over a 2-year period from beginning of Grade 2, when children were 7; 6 years old, to beginning of Grade 4. A battery of numerical processing tasks (dot enumeration, non-symbolic and symbolic comparison of one- and two-digit numbers, physical comparison, number line estimation) was given five times during the study (beginning and middle of each school year). Efficiency of numerical processing was a very good indicator of development in numerical processing while within-task effects remained largely constant and showed low long-term stability before middle of Grade 3. Children with dyscalculia showed less efficient numerical processing reflected in specifically prolonged response times. Importantly, they showed consistently larger slopes for dot enumeration in the subitizing range, an untypically large compatibility effect when processing two-digit numbers, and they were consistently less accurate in placing numbers on a number line. Thus, we were able to identify parameters that can be used in future research to characterize numerical processing in typical and dyscalculic development. These parameters can also be helpful for identification of children who struggle in their numerical development. PMID:23898310

Development of oral health policy in Nigeria: an analysis of the role of context, actors and policy process.

PubMed

Etiaba, Enyi; Uguru, Nkoli; Ebenso, Bassey; Russo, Giuliano; Ezumah, Nkoli; Uzochukwu, Benjamin; Onwujekwe, Obinna

2015-05-06

In Nigeria, there is a high burden of oral health diseases, poor coordination of health services and human resources for delivery of oral health services. Previous attempts to develop an Oral Health Policy (OHP) to decrease the oral disease burden failed. However, a policy was eventually developed in November 2012. This paper explores the role of contextual factors, actors and the policy process in the development of the OHP and possible reasons why the current approved OHP succeeded. The study was undertaken across Nigeria; information gathered through document reviews and in-depth interviews with five groups of purposively selected respondents. Analysis of the policy development process was guided by the policy triangle framework, examining context, policy process and actors involved in the policy development. The foremost enabling factor was the yearning among policy actors for a policy, having had four failed attempts. Other factors were the presence of a democratically elected government, a framework for health sector reform instituted by the Federal Ministry of Health (FMOH). The approved OHP went through all stages required for policy development unlike the previous attempts. Three groups of actors played crucial roles in the process, namely academics/researchers, development partners and policy makers. They either had decision making powers or influenced policy through funding or technical ability to generate credible research evidence, all sharing a common interest in developing the OHP. Although evidence was used to inform the development of the policy, the complex interactions between the context and actors facilitated its approval. The OHP development succeeded through a complex inter-relationship of context, process and actors, clearly illustrating that none of these factors could have, in isolation, catalyzed the policy development. Availability of evidence is necessary but not sufficient for developing policies in this area. Wider socio-political contexts in which actors develop policy can facilitate and/or constrain actors' roles and interests as well as policy process. These must be taken into consideration at stages of policy development in order to produce policies that will strengthen the health system, especially in low and middle-income countries, where policy processes and influences can be often less than transparent.

Case study: Lockheed-Georgia Company integrated design process

NASA Technical Reports Server (NTRS)

Waldrop, C. T.

1980-01-01

A case study of the development of an Integrated Design Process is presented. The approach taken in preparing for the development of an integrated design process includes some of the IPAD approaches such as developing a Design Process Model, cataloging Technical Program Elements (TPE's), and examining data characteristics and interfaces between contiguous TPE's. The implementation plan is based on an incremental development of capabilities over a period of time with each step directed toward, and consistent with, the final architecture of a total integrated system. Because of time schedules and different computer hardware, this system will not be the same as the final IPAD release; however, many IPAD concepts will no doubt prove applicable as the best approach. Full advantage will be taken of the IPAD development experience. A scenario that could be typical for many companies, even outside the aerospace industry, in developing an integrated design process for an IPAD-type environment is represented.

The 4 T's of Adulthood Development.

ERIC Educational Resources Information Center

Wood, Joanne M.

Although it may be so subtle that it is not noticed or sudden and life altering, adult development occurs in a cycle of four inherent processes: transaction, transition, transformation, and transcendence. These processes exist in a cycle characterized by growth and development. The processes can be defined as follows: (1) transaction--personal,…

Developing Partnerships To Meet Clients' Needs in Changing Government Organizations: A Consultative Process.

ERIC Educational Resources Information Center

Borgen, William A.

2000-01-01

Outlines the development of partnerships across three employment-related government ministries, in a context of organizational restructuring and downsizing. Describes a consultation process regarding effective collaboration to assess unemployed clients' employability needs. In meetings, the workers developed a process that involved the cooperation…

Sustaining Innovation: Developing an Instructional Technology Assessment Process

ERIC Educational Resources Information Center

Carmo, Monica Cristina

2013-01-01

This case study developed an instructional technology assessment process for the Gevirtz Graduate School of Education (GGSE). The theoretical framework of Adelman and Taylor (2001) guided the development of this instructional technology assessment process and the tools to aid in its facilitation. GGSE faculty, staff, and graduate students…

24 CFR 291.304 - Bidding process.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Bidding process. 291.304 Section 291.304 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... Family Mortgage Loans § 291.304 Bidding process. (a) Submission of bids. All bids must be submitted to...

Developing a taxonomy for mission architecture definition

NASA Technical Reports Server (NTRS)

Neubek, Deborah J.

1990-01-01

The Lunar and Mars Exploration Program Office (LMEPO) was tasked to define candidate architectures for the Space Exploration Initiative to submit to NASA senior management and an externally constituted Outreach Synthesis Group. A systematic, structured process for developing, characterizing, and describing the alternate mission architectures, and applying this process to future studies was developed. The work was done in two phases: (1) national needs were identified and categorized into objectives achievable by the Space Exploration Initiative; and (2) a program development process was created which both hierarchically and iteratively describes the program planning process.

Final Report - Energy Reduction and Advanced Water Removal via Membrane Solvent Extraction Technology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reed, John; Fanselow, Dan; Abbas, Charles

2014-08-06

3M and Archer Daniels Midland (ADM) collaborated with the U.S. Department of Energy (DOE) to develop and demonstrate a novel membrane solvent extraction (MSE) process that can substantially reduce energy and water consumption in ethanol production, and accelerate the fermentation process. A cross-flow membrane module was developed, using porous membrane manufactured by 3M. A pilot process was developed that integrates fermentation, MSE and vacuum distillation. Extended experiments of 48-72 hours each were conducted to develop the process, verify its performance and begin establishing commercial viability.

The Use of the Nursing Process in Spain as Compared to the United States and Canada.

PubMed

Huitzi-Egilegor, Joseba Xabier; Elorza-Puyadena, Maria Isabel; Asurabarrena-Iraola, Carmen

2017-05-18

To analyze the development of the nursing method process in Spain, and compare it with the development in the United States and Canada. This is a narrative review. The teaching of the nursing process in nursing schools started in Spain as from 1977 and that it started being used in professional practice in the 1990's. The development, the difficulties, the nursing models used and its application form are discussed. The development of the nursing process in the United States and Canada started to happen in Spain about 15-20 years later and, today, is a reality. Cross-sectional studies are needed to determine the changes in the development of the nursing process in Spain. © 2017 NANDA International, Inc.

The developmental processes for NANDA International Nursing Diagnoses.

PubMed

Scroggins, Leann M

2008-01-01

This study aims to provide a step-by-step procedural guideline for the development of a nursing diagnosis that meets the necessary criteria for inclusion in the NANDA International and NNN classification systems. The guideline is based on the processes developed by the Diagnosis Development Committee of NANDA International and includes the necessary processes for development of Actual, Wellness, Health Promotion, and Risk nursing diagnoses. Definitions of Actual, Wellness, Health Promotion, and Risk nursing diagnoses along with inclusion criteria and taxonomy rules have been incorporated into the guideline to streamline the development and review processes for submitted diagnoses. A step-by-step procedural guideline will assist the submitter to move efficiently and effectively through the submission process, resulting in increased submissions and enhancement of the NANDA International and NNN classification systems.

Facilitating Behavior Change With Low-literacy Patient Education Materials

PubMed Central

Seligman, Hilary K.; Wallace, Andrea S.; DeWalt, Darren A.; Schillinger, Dean; Arnold, Connie L.; Shilliday, Betsy Bryant; Delgadillo, Adriana; Bengal, Nikki; Davis, Terry C.

2014-01-01

Objective To describe a process for developing low-literacy health education materials that increase knowledge and activate patients toward healthier behaviors. Methods We developed a theoretically informed process for developing educational materials. This process included convening a multidisciplinary creative team, soliciting stakeholder input, identifying key concepts to be communicated, mapping concepts to a behavioral theory, creating a supporting behavioral intervention, designing and refining materials, and assessing efficacy. Results We describe the use of this process to develop a diabetes self-management guide. Conclusions Developing low-literacy health education materials that will activate patients toward healthier behaviors requires attention to factors beyond reading level. PMID:17931139

Computer-aided software development process design

NASA Technical Reports Server (NTRS)

Lin, Chi Y.; Levary, Reuven R.

1989-01-01

The authors describe an intelligent tool designed to aid managers of software development projects in planning, managing, and controlling the development process of medium- to large-scale software projects. Its purpose is to reduce uncertainties in the budget, personnel, and schedule planning of software development projects. It is based on dynamic model for the software development and maintenance life-cycle process. This dynamic process is composed of a number of time-varying, interacting developmental phases, each characterized by its intended functions and requirements. System dynamics is used as a modeling methodology. The resulting Software LIfe-Cycle Simulator (SLICS) and the hybrid expert simulation system of which it is a subsystem are described.

Application of high-throughput mini-bioreactor system for systematic scale-down modeling, process characterization, and control strategy development.

PubMed

Janakiraman, Vijay; Kwiatkowski, Chris; Kshirsagar, Rashmi; Ryll, Thomas; Huang, Yao-Ming

2015-01-01

High-throughput systems and processes have typically been targeted for process development and optimization in the bioprocessing industry. For process characterization, bench scale bioreactors have been the system of choice. Due to the need for performing different process conditions for multiple process parameters, the process characterization studies typically span several months and are considered time and resource intensive. In this study, we have shown the application of a high-throughput mini-bioreactor system viz. the Advanced Microscale Bioreactor (ambr15(TM) ), to perform process characterization in less than a month and develop an input control strategy. As a pre-requisite to process characterization, a scale-down model was first developed in the ambr system (15 mL) using statistical multivariate analysis techniques that showed comparability with both manufacturing scale (15,000 L) and bench scale (5 L). Volumetric sparge rates were matched between ambr and manufacturing scale, and the ambr process matched the pCO2 profiles as well as several other process and product quality parameters. The scale-down model was used to perform the process characterization DoE study and product quality results were generated. Upon comparison with DoE data from the bench scale bioreactors, similar effects of process parameters on process yield and product quality were identified between the two systems. We used the ambr data for setting action limits for the critical controlled parameters (CCPs), which were comparable to those from bench scale bioreactor data. In other words, the current work shows that the ambr15(TM) system is capable of replacing the bench scale bioreactor system for routine process development and process characterization. © 2015 American Institute of Chemical Engineers.

24 CFR 3288.110 - Alternative Process agreements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Alternative Process agreements... HOUSING AND URBAN DEVELOPMENT MANUFACTURED HOME DISPUTE RESOLUTION PROGRAM Alternative Process in HUD-Administered States § 3288.110 Alternative Process agreements. (a) Required agreement. To use the Alternative...

Advanced Research Deposition System (ARDS) for processing CdTe solar cells

NASA Astrophysics Data System (ADS)

Barricklow, Keegan Corey

CdTe solar cells have been commercialized at the Gigawatt/year level. The development of volume manufacturing processes for next generation CdTe photovoltaics (PV) with higher efficiencies requires research systems with flexibility, scalability, repeatability and automation. The Advanced Research Deposition Systems (ARDS) developed by the Materials Engineering Laboratory (MEL) provides such a platform for the investigation of materials and manufacturing processes necessary to produce the next generation of CdTe PV. Limited by previous research systems, the ARDS was developed to provide process and hardware flexibility, accommodating advanced processing techniques, and capable of producing device quality films. The ARDS is a unique, in-line process tool with nine processing stations. The system was designed, built and assembled at the Materials Engineering Laboratory. Final assembly, startup, characterization and process development are the focus of this research. Many technical challenges encountered during the startup of the ARDS were addressed in this research. In this study, several hardware modifications needed for the reliable operation of the ARDS were designed, constructed and successfully incorporated into the ARDS. The effect of process condition on film properties for each process step was quantified. Process development to achieve 12% efficient baseline solar cell required investigation of discrete processing steps, troubleshooting process variation, and developing performance correlations. Subsequent to this research, many advances have been demonstrated with the ARDS. The ARDS consistently produces devices of 12% +/-.5% by the process of record (POR). The champion cell produced to date utilizing the ARDS has an efficiency of 16.2% on low cost commercial sodalime glass and utilizes advanced films. The ARDS has enabled investigation of advanced concepts for processing CdTe devices including, Plasma Cleaning, Plasma Enhanced Closed Space Sublimation (PECSS), Electron Reflector (ER) using Cd1-xMgxTe (CMT) structure and alternative device structures. The ARDS has been instrumental in the collaborative research with many institutions.

Bockron as a Medium of Learning in The Process of Inquiry based Learning to Improve Science Process Skills of Junior High School Students in Growth and Development Concept

NASA Astrophysics Data System (ADS)

Mayasari, D.

2017-02-01

Investigative research on Influence of bockron as a medium of learning in process of inquiry-based learning to the development of science process skills on the concept of growth and development. This research was done in an effort to follow up underdeveloped skills of observing, communicating andconclude on students. This research was conducted using classroom action research (PTK), which consisted of 3 cycles. Cycle 1 students observe differences in growth and development, cycle 2 students measure the growth rate, cycle 3 students observe factors that influence growth and development, In these three cycles is used as a planting medium bocron (bottles and dacron). It involves 8th grade junior high-school students of 14-15 years old as research subjects in six meetings. Indicators of process skill include observation, communication, interpretation and inference. Data is collected through students’ work sheets, written tests and observation. Processing of the data to see N-Gain used Microsoft Excel 2007, and the results showed that an increase in science process skills with a value of medium N-Gain (0,63). Bokron learning medium easily and cheaply obtainable around the students, particularly those in urban areas is quite difficult to get land to be used as aplanting medium. In addition to observation of growth and development, bokron media can also be used to observe the motion in plants. The use bokron as a learning medium can train and develop science process skills, attitude and scientific method also gives students concrete experience of the process of growth and development in plants.

[Research advances in secondary development of Chinese patent medicines based on quality by design concept].

PubMed

Gong, Xing-Chu; Chen, Teng; Qu, Hai-Bin

2017-03-01

Quality by design (QbD) concept is an advanced pharmaceutical quality control concept. The application of QbD concept in the research and development of pharmaceutical processes of traditional Chinese medicines (TCM) mainly contains five parts, including the definition of critical processes and their evaluation criteria, the determination of critical process parameters and critical material attributes, the establishment of quantitative models, the development of design space, as well as the application and continuous improvement of control strategy. In this work, recent research advances in QbD concept implementation methods in the secondary development of Chinese patent medicines were reviewed, and five promising fields of the implementation of QbD concept were pointed out, including the research and development of TCM new drugs and Chinese medicine granules for formulation, modeling of pharmaceutical processes, development of control strategy based on industrial big data, strengthening the research of process amplification rules, and the development of new pharmaceutical equipment.. Copyright© by the Chinese Pharmaceutical Association.

Children's episodic memory.

PubMed

Ghetti, Simona; Lee, Joshua

2011-07-01

Episodic memory develops during childhood and adolescence. This trajectory depends on several underlying processes. In this article, we first discuss the development of the basic binding processes (e.g., the processes by which elements are bound together to form a memory episode) and control processes (e.g., reasoning and metamemory processes) involved in episodic remembering. Then, we discuss the role of these processes in false-memory formation. In the subsequent sections, we examine the neural substrates of the development of episodic memory. Finally, we discuss atypical development of episodic memory. As we proceed through the article, we suggest potential avenues for future research. WIREs Cogni Sci 2011 2 365-373 DOI: 10.1002/wcs.114 For further resources related to this article, please visit the WIREs website. Copyright © 2010 John Wiley & Sons, Ltd.

Flexible, secure agent development framework

DOEpatents

Goldsmith,; Steven, Y [Rochester, MN

2009-04-07

While an agent generator is generating an intelligent agent, it can also evaluate the data processing platform on which it is executing, in order to assess a risk factor associated with operation of the agent generator on the data processing platform. The agent generator can retrieve from a location external to the data processing platform an open site that is configurable by the user, and load the open site into an agent substrate, thereby creating a development agent with code development capabilities. While an intelligent agent is executing a functional program on a data processing platform, it can also evaluate the data processing platform to assess a risk factor associated with performing the data processing function on the data processing platform.

Risk management in medical product development process using traditional FMEA and fuzzy linguistic approach: a case study

NASA Astrophysics Data System (ADS)

Kirkire, Milind Shrikant; Rane, Santosh B.; Jadhav, Jagdish Rajaram

2015-12-01

Medical product development (MPD) process is highly multidisciplinary in nature, which increases the complexity and the associated risks. Managing the risks during MPD process is very crucial. The objective of this research is to explore risks during MPD in a dental product manufacturing company and propose a model for risk mitigation during MPD process to minimize failure events. A case study approach is employed. The existing MPD process is mapped with five phases of the customized phase gate process. The activities during each phase of development and risks associated with each activity are identified and categorized based on the source of occurrence. The risks are analyzed using traditional Failure mode and effect analysis (FMEA) and fuzzy FMEA. The results of two methods when compared show that fuzzy approach avoids the duplication of RPNs and helps more to convert cognition of experts into information to get values of risk factors. The critical, moderate, low level and negligible risks are identified based on criticality; risk treatments and mitigation model are proposed. During initial phases of MPD, the risks are less severe, but as the process progresses the severity of risks goes on increasing. The MPD process should be critically designed and simulated to minimize the number of risk events and their severity. To successfully develop the products/devices within the manufacturing companies, the process risk management is very essential. A systematic approach to manage risks during MPD process will lead to the development of medical products with expected quality and reliability. This is the first research of its kind having focus on MPD process risks and its management. The methodology adopted in this paper will help the developers, managers and researchers to have a competitive edge over the other companies by managing the risks during the development process.

Optimization of a novel enzyme treatment process for early-stage processing of sheepskins.

PubMed

Lim, Y F; Bronlund, J E; Allsop, T F; Shilton, A N; Edmonds, R L

2010-01-01

An enzyme treatment process for early-stage processing of sheepskins has been previously reported by the Leather and Shoe Research Association of New Zealand (LASRA) as an alternative to current industry operations. The newly developed process had marked benefits over conventional processing in terms of a lowered energy usage (73%), processing time (47%) as well as water use (49%), but had been developed as a "proof of principle''. The objective of this work was to develop the process further to a stage ready for adoption by industry. Mass balancing was used to investigate potential modifications for the process based on the understanding developed from a detailed analysis of preliminary design trials. Results showed that a configuration utilising a 2 stage counter-current system for the washing stages and segregation and recycling of enzyme float prior to dilution in the neutralization stage was a significant improvement. Benefits over conventional processing include a reduction of residual TDS by 50% at the washing stages and 70% savings on water use overall. Benefits over the un-optimized LASRA process are reduction of solids in product after enzyme treatment and neutralization stages by 30%, additional water savings of 21%, as well as 10% savings of enzyme usage.

Incorporating consideration of health impacts into land use development approval processes: Development of a Health Background Study Framework.

PubMed

Moloughney, Brent W; Bursey, Gayle E; Neumann, Jana; Leeming, Daniel H; Gutmann, Christine E; Sivanand, Bhavna; Mowat, David L

2014-09-12

This project involved development of a Health Background Study (HBS) Framework to support consideration of health impacts within municipalities' approval process for land use development. Peel Public Health and Toronto Public Health led the project with the participation of planners, urban designers, engineers, public health staff and development industry representatives. Historical growth in the Region of Peel and suburban Toronto has resulted in extensive low-density development, creating car-dependent communities with disconnected streets and segregated land uses. The inclusion of an HBS in developers' applications to municipalities is one approach by which health-related expectations for the built environment can be established within the approval process. Development of the HBS Framework used the six core elements of the built environment with the strongest evidence for impact on health and was informed by analysis of the provincial and local policy contexts, practices of other municipalities and stakeholder interviews. The Framework's contents were refined according to feedback from multidisciplinary stakeholder workshops. The HBS Framework identifies minimum standards for built environment core elements that developers need to address in their applications. The Framework was created to be simple and instructive with applicability to a range of development locations and scales, and to various stages of the development approval process. Peel Public Health is leading several initiatives to support the use of the HBS as a part of the development application process. The HBS Framework is a tool that public health and planning can use to support the consideration of health impacts within municipalities' land use development processes.

Low-cost Solar Array Project. Feasibility of the Silane Process for Producing Semiconductor-grade Silicon

NASA Technical Reports Server (NTRS)

1979-01-01

The feasibility of Union Carbide's silane process for commercial application was established. An integrated process design for an experimental process system development unit and a commercial facility were developed. The corresponding commercial plant economic performance was then estimated.

Capability Maturity Model (CMM) for Software Process Improvements

NASA Technical Reports Server (NTRS)

Ling, Robert Y.

2000-01-01

This slide presentation reviews the Avionic Systems Division's implementation of the Capability Maturity Model (CMM) for improvements in the software development process. The presentation reviews the process involved in implementing the model and the benefits of using CMM to improve the software development process.

Flat-plate solar array project: Experimental process system development unit for producing semiconductor-grade silicon using the silane-to-silicon process

NASA Technical Reports Server (NTRS)

1981-01-01

The engineering design, fabrication, assembly, operation, economic analysis, and process support research and development for an Experimental Process System Development Unit for producing semiconductor-grade silicon using the slane-to-silicon process are reported. The design activity was completed. About 95% of purchased equipment was received. The draft of the operations manual was about 50% complete and the design of the free-space system continued. The system using silicon power transfer, melting, and shotting on a psuedocontinuous basis was demonstrated.

Reasoning with case histories of process knowledge for efficient process development

NASA Technical Reports Server (NTRS)

Bharwani, Seraj S.; Walls, Joe T.; Jackson, Michael E.

1988-01-01

The significance of compiling case histories of empirical process knowledge and the role of such histories in improving the efficiency of manufacturing process development is discussed in this paper. Methods of representing important investigations as cases and using the information from such cases to eliminate redundancy of empirical investigations in analogous process development situations are also discussed. A system is proposed that uses such methods to capture the problem-solving framework of the application domain. A conceptual design of the system is presented and discussed.

Assessing the capability of high resolution climatic model experiments to simulate Mediterranean cyclonic tracks

NASA Astrophysics Data System (ADS)

Hatzaki, M.; Flocas, H. A.; Giannakopoulos, C.; Kostopoulou, E.; Kouroutzoglou, I.; Keay, K.; Simmonds, I.

2010-09-01

In this study, a comparison of a reanalysis driven simulation to a GCM driven simulation of a regional climate model is performed in order to assess the model's ability to capture the climatic characteristics of cyclonic tracks in the Mediterranean in the present climate. The ultimate scope of the study will be to perform a future climate projection related to cyclonic tracks in order to better understand and assess climate change in the Mediterranean. The climatology of the cyclonic tracks includes inter-monthly variations, classification of tracks according to their origin domain, dynamic and kinematic characteristics, as well as trend analysis. For this purpose, the ENEA model is employed based on PROTHEUS system composed of the RegCM atmospheric regional model and the MITgcm ocean model, coupled through the OASIS3 flux coupler. These model data became available through the EU Project CIRCE which aims to perform, for the first time, climate change projections with a realistic representation of the Mediterranean Sea. Two experiments are employed; a) the ERA402 with lateral Boundary conditions from ERA40 for the 43-year period 1958-2000, and b) the EH5OM_20C3M where the lateral boundary conditions for the atmosphere (1951-2000) are taken from the ECHAM5-MPIOM 20c3m global simulation (run3) included in the IPCC-AR4. The identification and tracking of cyclones is performed with the aid of the Melbourne University algorithm (MS algorithm), according to the Lagrangian perspective. MS algorithm characterizes a cyclone only if a vorticity maximum could be connected with a local pressure minimum. This approach is considered to be crucial, since open lows are also incorporated into the storm life-cycle, preventing possible inappropriate time series breaks, if a temporary weakening to an open-low state occurs. The model experiments verify that considerable inter-monthly variations of track density occur in the Mediterranean region, consistent with previous studies. The classification of the tracks according to their origin domain show that the vast majority originate within the examined area itself. The study of the kinematic and dynamic parameters of tracks according to their origin demonstrate that deeper cyclones follow the SW track. ACKNOWLEDGMENTS: M. Hatzaki would like to thank the Greek State Scholarships Foundation for financial support through the program of postdoctoral research. The support of EU-FP6 project CIRCE Integrated Project-Climate Change and Impact Research: the Mediterranean Environment (http://www.circeproject.eu) for climate model data provision is also greatly acknowledged.

Mitigation of Parallel RF Potentials by an Appropriate Antenna Design Using TOPICA

NASA Astrophysics Data System (ADS)

Maggiora, R.; Milanesio, D.

2011-12-01

A substantial effort has been devoted in recent years to the optimization of the ITER Ion Cyclotron (IC) launcher [1], above all with the aim of maximizing the coupling performances of the antenna; good improvements have been documented by using TOPICA code [2], a predictive tool for the design and optimization of RF launchers in front of a plasma region. Despite the progresses in the mentioned topic, this is not the only issue related to the design of IC antennas: a second crucial aspect is the impurities production, which is driven by the parallel RF potentials generated by the antenna itself and by the surrounding structures. The goal of this work is to analyze a set of innovative solutions that could be implemented in the next generation of IC antennas in order to mitigate the parallel RF potentials without reducing the power delivered to plasma. To achieve this challenging task, the TOPICA code has been adopted, taking advantage of recently introduced features. In particular, the code permits to compute the electric field distribution everywhere inside the antenna enclosure and in the plasma column, allowing to determine not only the magnitude and shape of the fields in front of the antenna, but also to evaluate their radial decay. Provided the electric field map, it is then possible to determine the parallel RF potentials and, even more important, to directly verify the impact of geometrical modifications of the front elements of the antenna on the RF potentials themselves. Furthermore, the capability to simulate the full 3D antenna with a high geometrical accuracy (as the one provided by commercial codes) and to account for an accurate plasma model indicates in TOPICA code a perfect candidate for this specific task. To lower the parallel RF potentials, two complementary approaches are outlined in the paper: the first one acts on the reduction of the electric field values, the second works on the minimization of the geometrical asymmetries. Pros and cons of the adopted solutions are discussed in detail. Two realistic cases have been taken into account in this work. Firstly, an ITER-like IC launcher has been adopted as a reference and optimized, then few solutions have been proposed for the ASDEX Upgrade experiment, with the final goal of testing the most promising concept for the machine in the coming years. This second activity has been carried out in collaboration with IPP-Garching and ENEA-Frascati.

Shear Wave Structure of Umbria and Marche, Italy, Strong Motion Seismometer Sites Affected by the 1997-98 Umbria-Marche, Italy, Earthquake Sequence

USGS Publications Warehouse

Kayen, Robert; Scasserra, Giuseppe; Stewart, Jonathan P.; Lanzo, Giuseppe

2008-01-01

A long sequence of earthquakes, eight with magnitudes between 5 and 6, struck the Umbria and Marche regions of central Italy between September 26, 1997 and July 1998. The earthquake swarm caused severe structural damage, particularly to masonry buildings, and resulted in the loss of twelve lives and about 150 injuries. The source of the events was a single seismogenic structure that consists of several faults with a prevailing northwest-southeast strike and crosses the Umbria-Marche border. The focal mechanism of the largest shocks indicates that the events were the product of shallow extensional normal faulting along a NE-SW extension perpendicular to the trend of the Apennines. The network of analog seismometer stations in the Umbria and Marche regions recorded motions of the main September and October 1997 events and a dense array of mobile digital stations, installed since September 29, recorded most of the swarm. The permanent national network Rete Accelerometrica Nazionale (RAN) is administered and maintained by Dipartimento delle Protezione Civile (DPC: Civil Protection Department); the temporary array was managed by Servizio Sismico Nazionale (SSN) in cooperation with small agencies and Universities. ENEA, the operator of many seismometer stations in Umbria, is the public Italian National Agency for New Technologies, Energy and the Environment. Many of the temporary and permanent stations in the Italian seismic network have little or no characterization of seismic velocities. In this study, we investigated 17 Italian sites using an active-source approach that employs low frequency harmonic waves to measure the dispersive nature of surface waves in the ground. We used the Spectral Analysis of Surface Wave (SASW) approach, coupled with an array of harmonic-wave electro-mechanical sources that are driven in-phase to excite the ground. An inversion algorithm using a non-linear least-squares best-fit method is used to compute shear wave velocities for up to 100 meters of the soil column. A draft report was published in the summer of 2008, followed by a comment period, lengthy discussions with Italian colleagues, and improved knowledge of the subsurface at the sites from soil logs. Four of the sites were reprocessed in order to correct issues with phase unwrapping of the field dispersion curves that complicated the velocity profile calculations at the lowest velocity sites. This report presents the final results from the reprocessing effort.

EFG Ribbon Technology

NASA Astrophysics Data System (ADS)

Schwirtlich, I. A.

Since the beginning of solar cell development based on crystalline silicon, there have been efforts to produce wafers directly from the melt instead of through crystallization of ingots. Ingots require slicing into the blocs and wafers which form the basis of solar cells. In the last 30 years, several dozen processes have been published that describe a variety of concepts. Only few of these processes could be developed to an acceptable degree of technical maturity. Among those successful technologies are the Dendritic Web process, the Edge Supported Pulling (ESP) process and the Edge-Defined-Film-Fed-Growth (EFG) process. The EFG Process was originally developed by Mobil Solar and, since the mid-1990s, belongs to SCHOTT Solar GmbH and its predecessors, respectively. The Ribbon Growth on Substrate (RGS) process was originally developed by Bayer AG and is now in a pilot project at the ECN, Petten. Considering the past 20 to 30 years, the EFG process has reached the most advanced state in terms of industrialization.

A mathematical study of a random process proposed as an atmospheric turbulence model

NASA Technical Reports Server (NTRS)

Sidwell, K.

1977-01-01

A random process is formed by the product of a local Gaussian process and a random amplitude process, and the sum of that product with an independent mean value process. The mathematical properties of the resulting process are developed, including the first and second order properties and the characteristic function of general order. An approximate method for the analysis of the response of linear dynamic systems to the process is developed. The transition properties of the process are also examined.

Reports of Planetary Geology Program, 1982

NASA Technical Reports Server (NTRS)

Holt, H. E. (Compiler)

1982-01-01

Work conducted in the Planetary Geology program is summarized. The following categories are presented: outer solar system satellites; asteroids and comets; Venus; cratering processes and landform development; volcanic processes and landforms; aolian processes and landforms; fluvial processes and landform development; periglacial and permafrost processes; structure, tectonics and stratigraphy; remote sensing and regolith studies; geologic mapping, cartography and geodesy.

Development of functionally-oriented technological processes of electroerosive processing

NASA Astrophysics Data System (ADS)

Syanov, S. Yu

2018-03-01

The stages of the development of functionally oriented technological processes of electroerosive processing from the separation of the surfaces of parts and their service functions to the determination of the parameters of the process of electric erosion, which will provide not only the quality parameters of the surface layer, but also the required operational properties, are described.

19 CFR 10.178 - Direct costs of processing operations performed in the beneficiary developing country.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 1 2011-04-01 2011-04-01 false Direct costs of processing operations performed in... processing operations performed in the beneficiary developing country. (a) Items included in the direct costs of processing operations. As used in § 10.176, the words “direct costs of processing operations...

System Engineering Processes at Kennedy Space Center for Development of the SLS and Orion Launch Systems

NASA Technical Reports Server (NTRS)

Schafer, Eric J.

2012-01-01

There are over 40 subsystems being developed for the future SLS and Orion Launch Systems at Kennedy Space Center. These subsystems developed at the Kennedy Space Center Engineering Directorate follow a comprehensive design process which requires several different product deliverables during each phase of each of the subsystems. This Paper describes this process and gives an example of where the process has been applied.

Development of shared decision-making resources to help inform difficult healthcare decisions: An example focused on dysvascular partial foot and transtibial amputations.

PubMed

Quigley, Matthew; Dillon, Michael P; Fatone, Stefania

2018-02-01

Shared decision making is a consultative process designed to encourage patient participation in decision making by providing accurate information about the treatment options and supporting deliberation with the clinicians about treatment options. The process can be supported by resources such as decision aids and discussion guides designed to inform and facilitate often difficult conversations. As this process increases in use, there is opportunity to raise awareness of shared decision making and the international standards used to guide the development of quality resources for use in areas of prosthetic/orthotic care. To describe the process used to develop shared decision-making resources, using an illustrative example focused on decisions about the level of dysvascular partial foot amputation or transtibial amputation. Development process: The International Patient Decision Aid Standards were used to guide the development of the decision aid and discussion guide focused on decisions about the level of dysvascular partial foot amputation or transtibial amputation. Examples from these shared decision-making resources help illuminate the stages of development including scoping and design, research synthesis, iterative development of a prototype, and preliminary testing with patients and clinicians not involved in the development process. Lessons learnt through the process, such as using the International Patient Decision Aid Standards checklist and development guidelines, may help inform others wanting to develop similar shared decision-making resources given the applicability of shared decision making to many areas of prosthetic-/orthotic-related practice. Clinical relevance Shared decision making is a process designed to guide conversations that help patients make an informed decision about their healthcare. Raising awareness of shared decision making and the international standards for development of high-quality decision aids and discussion guides is important as the approach is introduced in prosthetic-/orthotic-related practice.

Life-Span Learning: A Developmental Perspective

ERIC Educational Resources Information Center

Thornton, James E.

2003-01-01

The article discusses learning as embedded processes of development and aging, and as social activity over the life course. The concept of life-span learning is proposed and outlined to discuss these processes as aspects of and propositions in life-span development and aging theory. Life-span learning processes arise and continuously develop in a…

42 CFR 137.295 - May Self-Governance Tribes elect to develop their own environmental review process?

Code of Federal Regulations, 2011 CFR

2011-10-01

... own environmental review process? Yes, Self-Governance Tribes may develop their own environmental... 42 Public Health 1 2011-10-01 2011-10-01 false May Self-Governance Tribes elect to develop their own environmental review process? 137.295 Section 137.295 Public Health PUBLIC HEALTH SERVICE...

75 FR 41452 - Withdrawal of the Environmental Impact Statement (EIS) Development Process for the Proposed...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-16

... DEPARTMENT OF DEFENSE Department of the Army, Corps of Engineers Withdrawal of the Environmental Impact Statement (EIS) Development Process for the Proposed Beluga to Fairbanks (B2F) Natural Gas... discontinuing the EIS development process associated with the proposed B2F pipeline. FOR FURTHER INFORMATION...

78 FR 23550 - Department of Energy's (DOE) Participation in Development of the International Energy...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-19

...: Notice. SUMMARY: The DOE participates in the code development process of the International Code Council... notice outlines the process by which DOE produces code change proposals, and participates in the ICC code development process. FOR FURTHER INFORMATION CONTACT: Jeremiah Williams, U.S. Department of Energy, Office of...

This Is How We Do It: A Glimpse at Gamelab's Design Process

ERIC Educational Resources Information Center

Daer, Alice J.

2010-01-01

This article explicates the ways that developers working at an independent game company in New York City organized their development process around a deep concern for how players make meaning from their games. Two designers' descriptions of their processes are used to illustrate the company's commitment to developing games that invite…

Sensori-Motor Experience Leads to Changes in Visual Processing in the Developing Brain

ERIC Educational Resources Information Center

James, Karin Harman

2010-01-01

Since Broca's studies on language processing, cortical functional specialization has been considered to be integral to efficient neural processing. A fundamental question in cognitive neuroscience concerns the type of learning that is required for functional specialization to develop. To address this issue with respect to the development of neural…

The Development of Reading for Comprehension: An Information Processing Analysis. Final Report.

ERIC Educational Resources Information Center

Schadler, Margaret; Juola, James F.

This report summarizes research performed at the Universtiy of Kansas that involved several topics related to reading and learning to read, including the development of automatic word recognition processes, reading for comprehension, and the development of new computer technologies designed to facilitate the reading process. The first section…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simpson, L.; Britt, J.; Birkmire, R.

ITN Energy Systems, Inc., and Global Solar Energy, Inc., assisted by NREL's PV Manufacturing R&D program, have continued to advance CIGS production technology by developing trajectory-oriented predictive/control models, fault-tolerance control, control platform development, in-situ sensors, and process improvements. Modeling activities included developing physics-based and empirical models for CIGS and sputter-deposition processing, implementing model-based control, and applying predictive models to the construction of new evaporation sources and for control. Model-based control is enabled by implementing reduced or empirical models into a control platform. Reliability improvement activities include implementing preventive maintenance schedules; detecting failed sensors/equipment and reconfiguring to tinue processing; and systematicmore » development of fault prevention and reconfiguration strategies for the full range of CIGS PV production deposition processes. In-situ sensor development activities have resulted in improved control and indicated the potential for enhanced process status monitoring and control of the deposition processes. Substantial process improvements have been made, including significant improvement in CIGS uniformity, thickness control, efficiency, yield, and throughput. In large measure, these gains have been driven by process optimization, which in turn have been enabled by control and reliability improvements due to this PV Manufacturing R&D program.« less

Engineering Change Management Method Framework in Mechanical Engineering

NASA Astrophysics Data System (ADS)

Stekolschik, Alexander

2016-11-01

Engineering changes make an impact on different process chains in and outside the company, and lead to most error costs and time shifts. In fact, 30 to 50 per cent of development costs result from technical changes. Controlling engineering change processes can help us to avoid errors and risks, and contribute to cost optimization and a shorter time to market. This paper presents a method framework for controlling engineering changes at mechanical engineering companies. The developed classification of engineering changes and accordingly process requirements build the basis for the method framework. The developed method framework comprises two main areas: special data objects managed in different engineering IT tools and process framework. Objects from both areas are building blocks that can be selected to the overall business process based on the engineering process type and change classification. The process framework contains steps for the creation of change objects (both for overall change and for parts), change implementation, and release. Companies can select singleprocess building blocks from the framework, depending on the product development process and change impact. The developed change framework has been implemented at a division (10,000 employees) of a big German mechanical engineering company.

Managing the Public Sector Research and Development Portfolio Selection Process: A Case Study of Quantitative Selection and Optimization

DTIC Science & Technology

2016-09-01

PUBLIC SECTOR RESEARCH & DEVELOPMENT PORTFOLIO SELECTION PROCESS: A CASE STUDY OF QUANTITATIVE SELECTION AND OPTIMIZATION by Jason A. Schwartz...PUBLIC SECTOR RESEARCH & DEVELOPMENT PORTFOLIO SELECTION PROCESS: A CASE STUDY OF QUANTITATIVE SELECTION AND OPTIMIZATION 5. FUNDING NUMBERS 6...describing how public sector organizations can implement a research and development (R&D) portfolio optimization strategy to maximize the cost

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eshraghi, Ray

In September 2008, the U.S. Department of Energy and Martin County Economic Development Corporation entered into an agreement to further the advancement of a microtubular PEM fuel cell developed by Microcell Corporation. The overall focus of this project was on research and development related to high volume manufacturing of fuel cells and cost reduction in the fuel cell manufacturing process. The extrusion process used for the microfiber fuel cells in this project is inherently a low cost, high volume, high speed manufacturing process. In order to take advantage of the capabilities that the extrusion process provides, all subsequent manufacturing processesmore » must be enhanced to meet the extrusion line’s speed and output. Significant research and development was completed on these subsequent processes to ensure that power output and performance were not negatively impacted by the higher speeds, design changes and process improvements developed in this project. All tasks were successfully completed resulting in cost reductions, performance improvements and process enhancements in the areas of speed and quality. These results support the Department of Energy’s goal of fuel cell commercialization.« less

Methyl chloride via oxyhydrochlorination of methane: A building block for chemicals and fuels from natural gas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Benson, R.L.; Brown, S.S.D.; Ferguson, S.P.

1995-12-31

The objectives of this program are to (a) develop a process for converting natural gas to methyl chloride via an oxyhydrochlorination route using highly selective, stable catalysts in a fixed-bed, (b) design a reactor capable of removing the large amount of heat generated in the process so as to control the reaction, (c) develop a recovery system capable of removing the methyl chloride from the product stream and (d) determine the economics and commercial viability of the process. The general approach has been as follows: (a) design and build a laboratory scale reactor, (b) define and synthesize suitable OHC catalystsmore » for evaluation, (c) select first generation OHC catalyst for Process Development Unit (PDU) trials, (d) design, construct and startup PDU, (e) evaluate packed bed reactor design, (f) optimize process, in particular, product recovery operations, (g) determine economics of process, (h) complete preliminary engineering design for Phase II and (i) make scale-up decision and formulate business plan for Phase II. Conclusions regarding process development and catalyst development are presented.« less

KSC Shuttle ground turnaround evaluation

NASA Technical Reports Server (NTRS)

Ragusa, J. M.

1983-01-01

Payload/mission development, processing flows, facilities/systems, and the various environments to which a payload is exposed during ground processing are described. These considerations are important for payload design and ground processing requirements development.

Rapid process development of chromatographic process using direct analysis in real time mass spectrometry as a process analytical technology tool.

PubMed

Yan, Binjun; Chen, Teng; Xu, Zhilin; Qu, Haibin

2014-06-01

The concept of quality by design (QbD) is widely applied in the process development of pharmaceuticals. However, the additional cost and time have caused some resistance about QbD implementation. To show a possible solution, this work proposed a rapid process development method, which used direct analysis in real time mass spectrometry (DART-MS) as a process analytical technology (PAT) tool for studying the chromatographic process of Ginkgo biloba L., as an example. The breakthrough curves were fast determined by DART-MS at-line. A high correlation coefficient of 0.9520 was found between the concentrations of ginkgolide A determined by DART-MS and HPLC. Based on the PAT tool, the impacts of process parameters on the adsorption capacity were discovered rapidly, which showed a decreased adsorption capacity with the increase of the flow rate. This work has shown the feasibility and advantages of integrating PAT into QbD implementation for rapid process development. Copyright © 2014 Elsevier B.V. All rights reserved.

A ten-step process to develop case management plans.

PubMed

Tahan, Hussein A

2002-01-01

The use of case management plans has contained cost and improved quality of care successfully. However, the process of developing these plans remains a great challenge for healthcare executives, in this article, the author presents the answer to this challenge by discussing a 10-step formal process that administrators of patient care services and case managers can adapt to their institutions. It also can be used by interdisciplinary team members as a practical guide to develop a specific case management plan. This process is applicable to any care setting (acute, ambulatory, long term, and home care), diagnosis, or procedure. It is particularly important for those organizations that currently do not have a deliberate and systematic process to develop case management plans and are struggling with how to improve the efficiency and productivity of interdisciplinary teams charged with developing case management plans.

The software development process at the Chandra X-ray Center

NASA Astrophysics Data System (ADS)

Evans, Janet D.; Evans, Ian N.; Fabbiano, Giuseppina

2008-08-01

Software development for the Chandra X-ray Center Data System began in the mid 1990's, and the waterfall model of development was mandated by our documents. Although we initially tried this approach, we found that a process with elements of the spiral model worked better in our science-based environment. High-level science requirements are usually established by scientists, and provided to the software development group. We follow with review and refinement of those requirements prior to the design phase. Design reviews are conducted for substantial projects within the development team, and include scientists whenever appropriate. Development follows agreed upon schedules that include several internal releases of the task before completion. Feedback from science testing early in the process helps to identify and resolve misunderstandings present in the detailed requirements, and allows review of intangible requirements. The development process includes specific testing of requirements, developer and user documentation, and support after deployment to operations or to users. We discuss the process we follow at the Chandra X-ray Center (CXC) to develop software and support operations. We review the role of the science and development staff from conception to release of software, and some lessons learned from managing CXC software development for over a decade.

Development and evaluation of low cost honey heating-cum-filtration system.

PubMed

Alam, Md Shafiq; Sharma, D K; Sehgal, V K; Arora, M; Bhatia, S

2014-11-01

A fully mechanized honey heating-cum-filtration system was designed, developed, fabricated and evaluated for its performance. The system comprised of two sections; the top heating section and the lower filtering section. The developed system was evaluated for its performance at different process conditions (25 kg and 50 kg capacity using processing condition: 50 °C heating temperature and 60 °C heating temperature with 20 and 40 min holding time, respectively) and it was found that the total time required for heating, holding and filtration of honey was 108 and 142 min for 25 kg and 50 kg capacity of machine, respectively, irrespective of the processing conditions. The optimum capacity of the system was found to be 50 kg and it involved an investment of Rs 40,000 for its fabrication. The honey filtered through the developed filtration system was compared with the honey filtered in a high cost honey processing plant and raw honey for its microbial and biochemical (reducing sugars (%), moisture, acidity and pH) quality attributes. It was observed that the process of filtering through the developed unit resulted in reduction of microbes. The microbiological quality of honey filtered through the developed filtration system was better than that of raw honey and commercially processed honey. The treatment conditions found best in context of microbiological counts were 60 °C temperature for 20 min. There was 1.97 fold reductions in the plate count and 2.14 reductions in the fungal count of honey processed through the developed filtration system as compared to the raw honey. No coliforms were found in the processed honey. Honey processed through developed unit witnessed less moisture content, acidity and more reducing sugars as compared to raw honey, whereas its quality was comparable to the commercially processed honey.

Application of process mapping to understand integration of high risk medicine care bundles within community pharmacy practice.

PubMed

Weir, Natalie M; Newham, Rosemary; Corcoran, Emma D; Ali Atallah Al-Gethami, Ashwag; Mohammed Abd Alridha, Ali; Bowie, Paul; Watson, Anne; Bennie, Marion

2017-11-21

The Scottish Patient Safety Programme - Pharmacy in Primary Care collaborative is a quality improvement initiative adopting the Institute of Healthcare Improvement Breakthrough Series collaborative approach. The programme developed and piloted High Risk Medicine (HRM) Care Bundles (CB), focused on warfarin and non-steroidal anti-inflammatories (NSAIDs), within 27 community pharmacies over 4 NHS Regions. Each CB involves clinical assessment and patient education, although the CB content varies between regions. To support national implementation, this study aims to understand how the pilot pharmacies integrated the HRM CBs into routine practice to inform the development of a generic HRM CB process map. Regional process maps were developed in 4 pharmacies through simulation of the CB process, staff interviews and documentation of resources. Commonalities were collated to develop a process map for each HRM, which were used to explore variation at a national event. A single, generic process map was developed which underwent validation by case study testing. The findings allowed development of a generic process map applicable to warfarin and NSAID CB implementation. Five steps were identified as required for successful CB delivery: patient identification; clinical assessment; pharmacy CB prompt; CB delivery; and documentation. The generic HRM CB process map encompasses the staff and patients' journey and the CB's integration into routine community pharmacy practice. Pharmacist involvement was required only for clinical assessment, indicating suitability for whole-team involvement. Understanding CB integration into routine practice has positive implications for successful implementation. The generic process map can be used to develop targeted resources, and/or be disseminated to facilitate CB delivery and foster whole team involvement. Similar methods could be utilised within other settings, to allow those developing novel services to distil the key processes and consider their integration within routine workflows to effect maximal, efficient implementation and benefit to patient care. Copyright © 2017 Elsevier Inc. All rights reserved.

Analytical method for promoting process capability of shock absorption steel.

PubMed

Sung, Wen-Pei; Shih, Ming-Hsiang; Chen, Kuen-Suan

2003-01-01

Mechanical properties and low cycle fatigue are two factors that must be considered in developing new type steel for shock absorption. Process capability and process control are significant factors in achieving the purpose of research and development programs. Often-used evaluation methods failed to measure process yield and process centering; so this paper uses Taguchi loss function as basis to establish an evaluation method and the steps for assessing the quality of mechanical properties and process control of an iron and steel manufacturer. The establishment of this method can serve the research and development and manufacturing industry and lay a foundation in enhancing its process control ability to select better manufacturing processes that are more reliable than decision making by using the other commonly used methods.

The Iterative Design Process in Research and Development: A Work Experience Paper

NASA Technical Reports Server (NTRS)

Sullivan, George F. III

2013-01-01

The iterative design process is one of many strategies used in new product development. Top-down development strategies, like waterfall development, place a heavy emphasis on planning and simulation. The iterative process, on the other hand, is better suited to the management of small to medium scale projects. Over the past four months, I have worked with engineers at Johnson Space Center on a multitude of electronics projects. By describing the work I have done these last few months, analyzing the factors that have driven design decisions, and examining the testing and verification process, I will demonstrate that iterative design is the obvious choice for research and development projects.

An Information System Development Method Combining Business Process Modeling with Executable Modeling and its Evaluation by Prototyping

NASA Astrophysics Data System (ADS)

Okawa, Tsutomu; Kaminishi, Tsukasa; Hirabayashi, Syuichi; Suzuki, Ryo; Mitsui, Hiroyasu; Koizumi, Hisao

The business in the enterprise is closely related with the information system to such an extent that the business activities are difficult without the information system. The system design technique that considers the business process well, and that enables a quick system development is requested. In addition, the demand for the development cost is also severe than before. To cope with the current situation, the modeling technology named BPM(Business Process Management/Modeling)is drawing attention and becoming important as a key technology. BPM is a technology to model business activities as business processes and visualize them to improve the business efficiency. However, a general methodology to develop the information system using the analysis result of BPM doesn't exist, and a few development cases are reported. This paper proposes an information system development method combining business process modeling with executable modeling. In this paper we describe a guideline to support consistency of development and development efficiency and the framework enabling to develop the information system from model. We have prototyped the information system with the proposed method and our experience has shown that the methodology is valuable.

Software-Engineering Process Simulation (SEPS) model

NASA Technical Reports Server (NTRS)

Lin, C. Y.; Abdel-Hamid, T.; Sherif, J. S.

1992-01-01

The Software Engineering Process Simulation (SEPS) model is described which was developed at JPL. SEPS is a dynamic simulation model of the software project development process. It uses the feedback principles of system dynamics to simulate the dynamic interactions among various software life cycle development activities and management decision making processes. The model is designed to be a planning tool to examine tradeoffs of cost, schedule, and functionality, and to test the implications of different managerial policies on a project's outcome. Furthermore, SEPS will enable software managers to gain a better understanding of the dynamics of software project development and perform postmodern assessments.

A review of the silicon material task

NASA Technical Reports Server (NTRS)

Lutwack, R.

1984-01-01

The Silicon Material Task of the Flat-Plate Solar Array Project was assigned the objective of developing the technology for low-cost processes for producing polysilicon suitable for terrestrial solar-cell applications. The Task program comprised sections for process developments for semiconductor-grade and solar-cell-grade products. To provide information for deciding upon process designs, extensive investigations of the effects of impurities on material properties and the performance of cells were conducted. The silane process of the Union Carbide Corporation was carried through several stages of technical and engineering development; a pilot plant was the culmination of this effort. The work to establish silane fluidized-bed technology for a low-cost process is continuing. The advantages of the use of dichlorosilane is a siemens-type were shown by Hemlock Semiconductor Corporation. The development of other processes is described.

High‐Volume Processed, ITO‐Free Superstrates and Substrates for Roll‐to‐Roll Development of Organic Electronics

PubMed Central

Hösel, Markus; Angmo, Dechan; Søndergaard, Roar R.; dos Reis Benatto, Gisele A.; Carlé, Jon E.; Jørgensen, Mikkel

2014-01-01

The fabrication of substrates and superstrates prepared by scalable roll‐to‐roll methods is reviewed. The substrates and superstrates that act as the flexible carrier for the processing of functional organic electronic devices are an essential component, and proposals are made about how the general availability of various forms of these materials is needed to accelerate the development of the field of organic electronics. The initial development of the replacement of indium‐tin‐oxide (ITO) for the flexible carrier materials is described and a description of how roll‐to‐roll processing development led to simplification from an initially complex make‐up to higher performing materials through a more simple process is also presented. This process intensification through process simplification is viewed as a central strategy for upscaling, increasing throughput, performance, and cost reduction. PMID:27980893

A review of the silicon material task

NASA Astrophysics Data System (ADS)

Lutwack, R.

1984-02-01

The Silicon Material Task of the Flat-Plate Solar Array Project was assigned the objective of developing the technology for low-cost processes for producing polysilicon suitable for terrestrial solar-cell applications. The Task program comprised sections for process developments for semiconductor-grade and solar-cell-grade products. To provide information for deciding upon process designs, extensive investigations of the effects of impurities on material properties and the performance of cells were conducted. The silane process of the Union Carbide Corporation was carried through several stages of technical and engineering development; a pilot plant was the culmination of this effort. The work to establish silane fluidized-bed technology for a low-cost process is continuing. The advantages of the use of dichlorosilane is a siemens-type were shown by Hemlock Semiconductor Corporation. The development of other processes is described.

Basic visual perceptual processes in children with typical development and cerebral palsy: The processing of surface, length, orientation, and position.

PubMed

Schmetz, Emilie; Magis, David; Detraux, Jean-Jacques; Barisnikov, Koviljka; Rousselle, Laurence

2018-03-02

The present study aims to assess how the processing of basic visual perceptual (VP) components (length, surface, orientation, and position) develops in typically developing (TD) children (n = 215, 4-14 years old) and adults (n = 20, 20-25 years old), and in children with cerebral palsy (CP) (n = 86, 5-14 years old) using the first four subtests of the Battery for the Evaluation of Visual Perceptual and Spatial processing in children. Experiment 1 showed that these four basic VP processes follow distinct developmental trajectories in typical development. Experiment 2 revealed that children with CP present global and persistent deficits for the processing of basic VP components when compared with TD children matched on chronological age and nonverbal reasoning abilities.

Principles Supporting the Perceptional Teaching of Physics: A ``Practical Teaching Philosophy''

NASA Astrophysics Data System (ADS)

Kurki-Suonio, Kaarle

2011-03-01

This article sketches a framework of ideas developed in the context of decades of physics teacher-education that was entitled the "perceptional approach". Individual learning and the scientific enterprise are interpreted as different manifestations of the same process aimed at understanding the natural and social worlds. The process is understood to possess the basic nature of perception, where empirical meanings are first born and then conceptualised. The accumulation of perceived gestalts in the "structure of the mind" leads to structural perception and the generation of conceptual hierarchies, which form a general principle for the expansion of our understanding. The process undergoes hierarchical development from early sensory perception to individual learning and finally to science. The process is discussed in terms of a three-process dynamic. Scientific and technological processes are driven by the interaction of the mind and nature. They are embedded in the social process due to the interaction of individual minds. These sub-processes are defined by their aims: The scientific process affects the mind and aims at understanding; the technological process affects nature and aims at human well-being; and the social process aims at mutual agreement and cooperation. In hierarchical development the interaction of nature and the mind gets structured into a "methodical cycle" by procedures involving conscious activities. Its intuitive nature is preserved due to subordination of the procedures to empirical meanings. In physics, two dimensions of hierarchical development are distinguished: Unification development gives rise to a generalisation hierarchy of concepts; Quantification development transfers the empirical meanings to quantities, laws and theories representing successive hierarchical levels of quantitative concepts. Consequences for physics teaching are discussed in principle, and in the light of examples and experiences from physics teacher education.

Design, Development and Hotfire Testing of Monolithic Copper and Bimetallic Additively Manufactured Combustion Chambers

NASA Technical Reports Server (NTRS)

Gradl, Paul; Barnett, Greg; Brandsmeier, Will; Greene, Sandy Elam; Protz, Chris

2016-01-01

NASA and industry partners are working towards fabrication process development to reduce costs and schedules associated with manufacturing liquid rocket engine components with the goal of reducing overall mission costs. One such technique being evaluated is powder-bed fusion or selective laser melting (SLM) otherwise commonly referred to as additive manufacturing. The NASA Low Cost Upper Stage Propulsion (LCUSP) program was designed to develop processes and material characterization for the GRCop-84 copper-alloy commensurate with powder bed additive manufacturing, evaluate bimetallic deposition and complete testing of a full scale combustion chamber. As part of this development, the process has been transferred to industry partners to enable a long-term supply chain of monolithic copper combustion chambers. As a direct spin off of this program, NASA is working with industry partners to further develop the printing process for the GRCop-84 material in addition to the C-18150 (CuCrZr) material. To advance the process further and allow for optimization with multiple materials, NASA is also investigating the feasibility of bimetallic additively manufactured chambers. A 1.2k sized thrust-chamber was designed and developed to compare the printing process of the GRCop-84 and C-18150 SLM materials. A series of similar MCC liners also completed development with an Inconel 625 jacket bonded to the GRcop-84 liner evaluating direct metal deposition (DMD) laser and arc-based techniques. This paper describes the design, development, manufacturing and testing of these combustion chambers and associated lessons learned throughout the design and development process.

A Proven Method for Meeting Export Control Objectives in Postal and Shipping Sectors

DTIC Science & Technology

2015-02-01

Mellon University for the operation of the Software Engineering Institute, a federally funded research and development center sponsored by the United...Export Control at USPS 5 3.3 Objectives for Improving Export Screening at USPS 6 4 Development of the New Screening Process 7 4.1 “Walking the Model...Export Screening Development Process 10 Figure 2: Induction and Processing of International Mail 10 Figure 3: The Export Screening Process 11

System Engineering Processes at Kennedy Space Center for Development of SLS and Orion Launch Systems

NASA Technical Reports Server (NTRS)

Schafer, Eric; Stambolian, Damon; Henderson, Gena

2013-01-01

There are over 40 subsystems being developed for the future SLS and Orion Launch Systems at Kennedy Space Center. These subsystems are developed at the Kennedy Space Center Engineering Directorate. The Engineering Directorate at Kennedy Space Center follows a comprehensive design process which requires several different product deliverables during each phase of each of the subsystems. This Presentation describes this process with examples of where the process has been applied.

Exploratory Development on a New Process to Produce Improved RDX crystals: Supercritical Fluid Anti-Solvent Recrystallization

DTIC Science & Technology

1988-05-02

G. and J. Chiovini. Decaffeination Process . U.S. Patent 4,251.559; 17 February 1981. 43. Friedrich, J.P.. G.R. List, and A.J. Leakin. Petroleum...0 CONTRACT REPORT BRL-CR-606 EXPLORATORY DEVELOPMENT ON A NEW PROCESS TO PRODUCE IMPROVED RDX CRYSTALS: SUPERCRITICAL FLUID ANTI-SOLVENT...CCESSION NO. 11. TITLE (icnude Sun• y Uasuihcanon) I . • EXPLORATORY DEVELOPMENT ON A NEW PROCESS TO PRODUCE IMPROVED RDX CRYSTALS: SUPERCRITICAL

The Package-Based Development Process in the Flight Dynamics Division

NASA Technical Reports Server (NTRS)

Parra, Amalia; Seaman, Carolyn; Basili, Victor; Kraft, Stephen; Condon, Steven; Burke, Steven; Yakimovich, Daniil

1997-01-01

The Software Engineering Laboratory (SEL) has been operating for more than two decades in the Flight Dynamics Division (FDD) and has adapted to the constant movement of the software development environment. The SEL's Improvement Paradigm shows that process improvement is an iterative process. Understanding, Assessing and Packaging are the three steps that are followed in this cyclical paradigm. As the improvement process cycles back to the first step, after having packaged some experience, the level of understanding will be greater. In the past, products resulting from the packaging step have been large process documents, guidebooks, and training programs. As the technical world moves toward more modularized software, we have made a move toward more modularized software development process documentation, as such the products of the packaging step are becoming smaller and more frequent. In this manner, the QIP takes on a more spiral approach rather than a waterfall. This paper describes the state of the FDD in the area of software development processes, as revealed through the understanding and assessing activities conducted by the COTS study team. The insights presented include: (1) a characterization of a typical FDD Commercial Off the Shelf (COTS) intensive software development life-cycle process, (2) lessons learned through the COTS study interviews, and (3) a description of changes in the SEL due to the changing and accelerating nature of software development in the FDD.

E-Learning Quality Assurance: A Process-Oriented Lifecycle Model

ERIC Educational Resources Information Center

Abdous, M'hammed

2009-01-01

Purpose: The purpose of this paper is to propose a process-oriented lifecycle model for ensuring quality in e-learning development and delivery. As a dynamic and iterative process, quality assurance (QA) is intertwined with the e-learning development process. Design/methodology/approach: After reviewing the existing literature, particularly…

Development of Pulsed Processes for the Manufacture of Solar Cells

NASA Technical Reports Server (NTRS)

1979-01-01

The development status of the process based upon ion implantation for the introduction of junctions and back surface fields is described. A process sequence is presented employing ion implantation and pulse processing. Efforts to improve throughout and descrease process element costs for furnace annealing are described. Design studies for a modular 3,000 wafer per hour pulse processor are discussed.

Aqueous and pyrochemical reprocessing of actinide fuels

NASA Astrophysics Data System (ADS)

Toth, L. Mac; Bond, Walter D.; Avens, Larry R.

1993-02-01

Processing of the nuclear fuel actinides has developed in two independent directions—aqueous processing and pyroprocessing. Similarities in the two processes, their goals, and restraints are indicated in brief parallel descriptions along with distinguishing advantages and areas of future development. It is suggested that from a technical viewpoint, the ultimate process might be a hybrid which incorporates the best steps of each process.

Collaborative Measurement Development as a Tool in CBPR: Measurement Development and Adaptation within the Cultures of Communities

PubMed Central

Gonzalez, John; Trickett, Edison J.

2014-01-01

This paper describes the processes we engaged in to develop a measurement protocol used to assess the outcomes in a community based suicide and alcohol abuse prevention project with two Alaska Native communities. While the literature on community-based participatory research (CBPR) is substantial regarding the importance of collaborations, few studies have reported on this collaboration in the process of developing measures to assess CBPR projects. We first tell a story of the processes around the standard issues of doing cross-cultural work on measurement development related to areas of equivalence. A second story is provided that highlights how community differences within the same cultural group can affect both the process and content of culturally relevant measurement selection, adaptation, and development. PMID:24748283

Collaborative measurement development as a tool in CBPR: measurement development and adaptation within the cultures of communities.

PubMed

Gonzalez, John; Trickett, Edison J

2014-09-01

This paper describes the processes we engaged into develop a measurement protocol used to assess the outcomes in a community based suicide and alcohol abuse prevention project with two Alaska Native communities. While the literature on community-based participatory research (CBPR) is substantial regarding the importance of collaborations, few studies have reported on this collaboration in the process of developing measures to assess CBPR projects. We first tell a story of the processes around the standard issues of doing cross-cultural work on measurement development related to areas of equivalence. A second story is provided that highlights how community differences within the same cultural group can affect both the process and content of culturally relevant measurement selection, adaptation, and development.

Space experiment development process

NASA Technical Reports Server (NTRS)

Depauw, James F.

1987-01-01

Described is a process for developing space experiments utilizing the Space Shuttle. The role of the Principal Investigator is described as well as the Principal Investigator's relation with the project development team. Described also is the sequence of events from an early definition phase through the steps of hardware development. The major interactions between the hardware development program and the Shuttle integration and safety activities are also shown. The presentation is directed to people with limited Shuttle experiment experience. The objective is to summarize the development process, discuss the roles of major participants, and list some lessons learned. Two points should be made at the outset. First, no two projects are the same so the process varies from case to case. Second, the emphasis here is on Code EN/Microgravity Science and Applications Division (MSAD).

The Use of Multi-Criteria Evaluation and Network Analysis in the Area Development Planning Process

DTIC Science & Technology

2013-03-01

layouts. The alternative layout scoring process, base in multi-criteria evaluation, returns a quantitative score for each alternative layout and a...The purpose of this research was to develop improvements to the area development planning process. These plans are used to improve operations within...an installation sub-section by altering the physical layout of facilities. One methodology was developed based on apply network analysis concepts to

76 FR 81906 - Advance Notice of Proposed Rulemaking Regarding a Competitive Process for Leasing Public Lands...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-29

... Solar and Wind Energy Development AGENCY: Bureau of Land Management. ACTION: Advance notice of proposed... to establish a competitive process for leasing public lands for solar and wind energy development... process for issuing Right-of-Way (ROW) leases for solar and wind energy development that is based upon the...

The Community Development Process: The Rediscovery of Local Initiative.

ERIC Educational Resources Information Center

Biddle, William W.; Biddle, Loureide J.

The development process in two communities, a mining county in rural Appalachia and a deteriorating neighborhood in a northern industrial city, is presented in case-study form. Concepts and commonly used terms are defined; a process of development is identified that can be used in groups small enough to permit attention to the growth of persons.…

Concept Development in Learning Physics: The Case of Electric Current and Voltage Revisited

ERIC Educational Resources Information Center

Koponen, Ismo T.; Huttunen, Laura

2013-01-01

In learning conceptual knowledge in physics, a common problem is the development and differentiation of concepts in the learning process. An important part of this development process is the re-organisation or re-structuring process in which students' conceptual knowledge and concepts change. This study proposes a new view of concept…

Airport Planning and Development Process: Analysis and Documentation Report

DOT National Transportation Integrated Search

1997-01-01

The Federal Aviation Administration (FAA) is facing extreme resource constraints : and increasing demands on the aviation system. The Airport Planning and : Development Process (APDP) links organizations, people, and processes together : to provide c...

Developing the JPL Engineering Processes

NASA Technical Reports Server (NTRS)

Linick, Dave; Briggs, Clark

2004-01-01

This paper briefly recounts the recent history of process reengineering at the NASA Jet Propulsion Laboratory, with a focus on the engineering processes. The JPL process structure is described and the process development activities of the past several years outlined. The main focus of the paper is on the current process structure, the emphasis on the flight project life cycle, the governance approach that lead to Flight Project Practices, and the remaining effort to capture process knowledge at the detail level of the work group.

On the facilitative effects of face motion on face recognition and its development

PubMed Central

Xiao, Naiqi G.; Perrotta, Steve; Quinn, Paul C.; Wang, Zhe; Sun, Yu-Hao P.; Lee, Kang

2014-01-01

For the past century, researchers have extensively studied human face processing and its development. These studies have advanced our understanding of not only face processing, but also visual processing in general. However, most of what we know about face processing was investigated using static face images as stimuli. Therefore, an important question arises: to what extent does our understanding of static face processing generalize to face processing in real-life contexts in which faces are mostly moving? The present article addresses this question by examining recent studies on moving face processing to uncover the influence of facial movements on face processing and its development. First, we describe evidence on the facilitative effects of facial movements on face recognition and two related theoretical hypotheses: the supplementary information hypothesis and the representation enhancement hypothesis. We then highlight several recent studies suggesting that facial movements optimize face processing by activating specific face processing strategies that accommodate to task requirements. Lastly, we review the influence of facial movements on the development of face processing in the first year of life. We focus on infants' sensitivity to facial movements and explore the facilitative effects of facial movements on infants' face recognition performance. We conclude by outlining several future directions to investigate moving face processing and emphasize the importance of including dynamic aspects of facial information to further understand face processing in real-life contexts. PMID:25009517

Multilayer ultra thick resist development for MEMS

NASA Astrophysics Data System (ADS)

Washio, Yasushi; Senzaki, Takahiro; Masuda, Yasuo; Saito, Koji; Obiya, Hiroyuki

2005-05-01

MEMS (Micro-Electro-Mechanical Systems) is achieved through a process technology, called Micro-machining. There are two distinct methods to manufacture a MEMS-product. One method is to form permanent film through photolithography, and the other is to form a non-permanent film resist after photolithography proceeded by etch or plating process. The three-dimensional ultra-fine processing technology based on photolithography, and is assembled by processes, such as anode junction, and post lithography processes such as etching and plating. Currently ORDYL PR-100 (Dry Film Type) is used for the permanent resist process. TOK has developed TMMR S2000 (Liquid Type) and TMMF S2000 (Dry Film Type) also. TOK has developed a new process utilizing these resist. The electro-forming method by photolithography is developed as one of the methods for enabling high resolution and high aspect formation. In recent years, it has become possible to manufacture conventionally difficult multilayer through our development with material and equipment project (M&E). As for material for electro-forming, it was checked that chemically amplified resist is optimal from the reaction mechanism as it is easily removed by the clean solution. Moreover, multiple plating formations were enabled with the resist through a new process. As for the equipment, TOK developed Applicator (It can apply 500 or more μms) and Developer, which achieves high throughput and quality. The detailed plating formations, which a path differs, and air wiring are realizable through M&E. From the above results, opposed to metallic mold plating, electro-forming method by resist, enabled to form high resolution and aspect pattern, at low cost. It is thought that the infinite possibility spreads by applying this process.

Process development of a New Haemophilus influenzae type b conjugate vaccine and the use of mathematical modeling to identify process optimization possibilities.

PubMed

Hamidi, Ahd; Kreeftenberg, Hans; V D Pol, Leo; Ghimire, Saroj; V D Wielen, Luuk A M; Ottens, Marcel

2016-05-01

Vaccination is one of the most successful public health interventions being a cost-effective tool in preventing deaths among young children. The earliest vaccines were developed following empirical methods, creating vaccines by trial and error. New process development tools, for example mathematical modeling, as well as new regulatory initiatives requiring better understanding of both the product and the process are being applied to well-characterized biopharmaceuticals (for example recombinant proteins). The vaccine industry is still running behind in comparison to these industries. A production process for a new Haemophilus influenzae type b (Hib) conjugate vaccine, including related quality control (QC) tests, was developed and transferred to a number of emerging vaccine manufacturers. This contributed to a sustainable global supply of affordable Hib conjugate vaccines, as illustrated by the market launch of the first Hib vaccine based on this technology in 2007 and concomitant price reduction of Hib vaccines. This paper describes the development approach followed for this Hib conjugate vaccine as well as the mathematical modeling tool applied recently in order to indicate options for further improvements of the initial Hib process. The strategy followed during the process development of this Hib conjugate vaccine was a targeted and integrated approach based on prior knowledge and experience with similar products using multi-disciplinary expertise. Mathematical modeling was used to develop a predictive model for the initial Hib process (the 'baseline' model) as well as an 'optimized' model, by proposing a number of process changes which could lead to further reduction in price. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 32:568-580, 2016. © 2016 American Institute of Chemical Engineers.

The roles of a process development group in biopharmaceutical process startup.

PubMed

Goochee, Charles F

2002-01-01

The transfer of processes for biotherapeutic products into finalmanufacturing facilities was frequently problematic during the 1980's and early 1990's, resulting in costly delays to licensure(Pisano 1997). While plant startups for this class of products can become chaotic affairs, this is not an inherent or intrinsic feature. Major classes of process startup problems have been identified andmechanisms have been developed to reduce their likelihood of occurrence. These classes of process startup problems and resolution mechanisms are the major topic of this article. With proper planning and sufficient staffing, the probably of a smooth process startup for a biopharmaceutical product can be very high - i.e., successful process performance will often beachieved within the first two full-scale process lots in the plant. The primary focus of this article is the role of the Process Development Group in helping to assure this high probability of success.

Massively parallel information processing systems for space applications

NASA Technical Reports Server (NTRS)

Schaefer, D. H.

1979-01-01

NASA is developing massively parallel systems for ultra high speed processing of digital image data collected by satellite borne instrumentation. Such systems contain thousands of processing elements. Work is underway on the design and fabrication of the 'Massively Parallel Processor', a ground computer containing 16,384 processing elements arranged in a 128 x 128 array. This computer uses existing technology. Advanced work includes the development of semiconductor chips containing thousands of feedthrough paths. Massively parallel image analog to digital conversion technology is also being developed. The goal is to provide compact computers suitable for real-time onboard processing of images.

Multiscale and Multiphysics Modeling of Additive Manufacturing of Advanced Materials

NASA Technical Reports Server (NTRS)

Liou, Frank; Newkirk, Joseph; Fan, Zhiqiang; Sparks, Todd; Chen, Xueyang; Fletcher, Kenneth; Zhang, Jingwei; Zhang, Yunlu; Kumar, Kannan Suresh; Karnati, Sreekar

2015-01-01

The objective of this proposed project is to research and develop a prediction tool for advanced additive manufacturing (AAM) processes for advanced materials and develop experimental methods to provide fundamental properties and establish validation data. Aircraft structures and engines demand materials that are stronger, useable at much higher temperatures, provide less acoustic transmission, and enable more aeroelastic tailoring than those currently used. Significant improvements in properties can only be achieved by processing the materials under nonequilibrium conditions, such as AAM processes. AAM processes encompass a class of processes that use a focused heat source to create a melt pool on a substrate. Examples include Electron Beam Freeform Fabrication and Direct Metal Deposition. These types of additive processes enable fabrication of parts directly from CAD drawings. To achieve the desired material properties and geometries of the final structure, assessing the impact of process parameters and predicting optimized conditions with numerical modeling as an effective prediction tool is necessary. The targets for the processing are multiple and at different spatial scales, and the physical phenomena associated occur in multiphysics and multiscale. In this project, the research work has been developed to model AAM processes in a multiscale and multiphysics approach. A macroscale model was developed to investigate the residual stresses and distortion in AAM processes. A sequentially coupled, thermomechanical, finite element model was developed and validated experimentally. The results showed the temperature distribution, residual stress, and deformation within the formed deposits and substrates. A mesoscale model was developed to include heat transfer, phase change with mushy zone, incompressible free surface flow, solute redistribution, and surface tension. Because of excessive computing time needed, a parallel computing approach was also tested. In addition, after investigating various methods, a Smoothed Particle Hydrodynamics Model (SPH Model) was developed to model wire feeding process. Its computational efficiency and simple architecture makes it more robust and flexible than other models. More research on material properties may be needed to realistically model the AAM processes. A microscale model was developed to investigate heterogeneous nucleation, dendritic grain growth, epitaxial growth of columnar grains, columnar-to-equiaxed transition, grain transport in melt, and other properties. The orientations of the columnar grains were almost perpendicular to the laser motion's direction. Compared to the similar studies in the literature, the multiple grain morphology modeling result is in the same order of magnitude as optical morphologies in the experiment. Experimental work was conducted to validate different models. An infrared camera was incorporated as a process monitoring and validating tool to identify the solidus and mushy zones during deposition. The images were successfully processed to identify these regions. This research project has investigated multiscale and multiphysics of the complex AAM processes thus leading to advanced understanding of these processes. The project has also developed several modeling tools and experimental validation tools that will be very critical in the future of AAM process qualification and certification.

The Effects of Radiation Chemistry on Solvent Extraction: 1. Conditions in Acidic Solution and a Review of TBP Radiolysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bruce J. Mincher; Guiseppe Modolo; Strephen P. Mezyk

2009-01-01

Solvent extraction is the most commonly used process scale separation technique for nuclear applications and it benefits from more than 60 years of research and development and proven experience at the industrial scale. Advanced solvent extraction processes for the separation of actinides and fission products from dissolved nuclear fuel are now being investigated worldwide by numerous groups (US, Europe, Russia, Japan etc.) in order to decrease the radiotoxic inventories of nuclear waste. While none of the advanced processes have yet been implemented at the industrial scale their development studies have sometimes reached demonstration tests at the laboratory scale. Most ofmore » the partitioning strategies rely on the following four separations: 1. Partitioning of uranium and/or plutonium from spent fuel dissolution liquors. 2. Separation of the heat generating fission products such as strontium and cesium. 3. Coextraction of the trivalent actinides and lanthanides. 4. Separation of the trivalent actinides from the trivalent lanthanides. Tributylphosphate (TBP) in the first separation is the basis of the PUREX, UREX and COEX processes, developed in Europe and the US, whereas monoamides as alternatives for TBP are being developed in Japan and India. For the second separation, many processes were developed worldwide, including the use of crown-ether extractants, like the FPEX process developed in the USA, and the CCD-PEG process jointly developed in the USA and Russia for the partitioning of cesium and strontium. In the third separation, phosphine oxides (CMPOs), malonamides, and diglycolamides are used in the TRUEX, DIAMEX and the ARTIST processes, respectively developed in US, Europe and Japan. Trialkylphosphine oxide(TRPO) developed in China, or UNEX (a mixture of several extractants) jointly developed in Russia and the USA allow all actinides to be co-extracted from acidic radioactive liquid waste. For the final separation, soft donor atom-containing ligands such as the bistriazinylbipyridines (BTBPs) or dithiophosphinic acids have been developed in Europe and China to selectively extract the trivalent actinides. However, in the TALSPEAK process developed in the USA, the separation is based on the relatively high affinity of aminopolycarboxylic acid complexants such as DTPA for trivalent actinides over lanthanides. In the DIDPA, SETFICS and the GANEX processes, developed in Japan and France, the group separation is accomplished in a reverse TALSPEAK process. A typical scenario is shown in Figure 1 for the UREX1a (Uranium Extraction version 1a) process. The initial step is the TBP extraction for the separation of recyclable uranium. The second step partitions the short-lived, highly radioactive cesium and strontium to minimize heat loading in the high-level waste repository. The third step is a group separation of the trivalent actinides and lanthanides with the last step being partitioning of the trivalent lanthanides from the actinides.« less

Materials, Processes and Manufacturing in Ares 1 Upper Stage: Integration with Systems Design and Development

NASA Technical Reports Server (NTRS)

Bhat, Biliyar N.

2008-01-01

Ares I Crew Launch Vehicle Upper Stage is designed and developed based on sound systems engineering principles. Systems Engineering starts with Concept of Operations and Mission requirements, which in turn determine the launch system architecture and its performance requirements. The Ares I-Upper Stage is designed and developed to meet these requirements. Designers depend on the support from materials, processes and manufacturing during the design, development and verification of subsystems and components. The requirements relative to reliability, safety, operability and availability are also dependent on materials availability, characterization, process maturation and vendor support. This paper discusses the roles and responsibilities of materials and manufacturing engineering during the various phases of Ares IUS development, including design and analysis, hardware development, test and verification. Emphasis is placed how materials, processes and manufacturing support is integrated over the Upper Stage Project, both horizontally and vertically. In addition, the paper describes the approach used to ensure compliance with materials, processes, and manufacturing requirements during the project cycle, with focus on hardware systems design and development.

How does Learning Impact Development in Infancy? The Case of Perceptual Organization

PubMed Central

Bhatt, Ramesh S.; Quinn, Paul C.

2011-01-01

Pattern perception and organization are critical functions of the visual cognition system. Many organizational processes are available early in life, such that infants as young 3 months of age are able to readily utilize a variety of cues to organize visual patterns. However, other processes are not readily evident in young infants, and their development involves perceptual learning. We describe a theoretical framework that addresses perceptual learning in infancy and the manner in which it affects visual organization and development. It identifies five kinds of experiences that induce learning, and suggests that they work via attentional and unitization mechanisms to modify visual organization. In addition, the framework proposes that this kind of learning is abstract, domain general, functional at different ages in a qualitatively similar manner, and has a long-term impact on development through a memory reactivation process. Although most models of development assume that experience is fundamental to development, very little is actually known about the process by which experience affects development. The proposed framework is an attempt to account for this process in the domain of perception. PMID:21572570

Development of a data acquisition system using a RISC/UNIX TM workstation

NASA Astrophysics Data System (ADS)

Takeuchi, Y.; Tanimori, T.; Yasu, Y.

1993-05-01

We have developed a compact data acquisition system on RISC/UNIX workstations. A SUN TM SPARCstation TM IPC was used, in which an extension bus "SBus TM" was linked to a VMEbus. The transfer rate achieved was better than 7 Mbyte/s between the VMEbus and the SUN. A device driver for CAMAC was developed in order to realize an interruptive feature in UNIX. In addition, list processing has been incorporated in order to keep the high priority of the data handling process in UNIX. The successful developments of both device driver and list processing have made it possible to realize the good real-time feature on the RISC/UNIX system. Based on this architecture, a portable and versatile data taking system has been developed, which consists of a graphical user interface, I/O handler, user analysis process, process manager and a CAMAC device driver.

Scale-up of mild gasification to be a process development unit mildgas 24 ton/day PDU design report. Final report, November 1991--July 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

From November 1991 to April 1996, Kerr McGee Coal Corporation (K-M Coal) led a project to develop the Institute of Gas Technology (IGT) Mild Gasification (MILDGAS) process for near-term commercialization. The specific objectives of the program were to: design, construct, and operate a 24-tons/day adiabatic process development unit (PDU) to obtain process performance data suitable for further design scale-up; obtain large batches of coal-derived co-products for industrial evaluation; prepare a detailed design of a demonstration unit; and develop technical and economic plans for commercialization of the MILDGAS process. The project team for the PDU development program consisted of: K-M Coal,more » IGT, Bechtel Corporation, Southern Illinois University at Carbondale (SIUC), General Motors (GM), Pellet Technology Corporation (PTC), LTV Steel, Armco Steel, Reilly Industries, and Auto Research.« less

Advanced technology development for image gathering, coding, and processing

NASA Technical Reports Server (NTRS)

Huck, Friedrich O.

1990-01-01

Three overlapping areas of research activities are presented: (1) Information theory and optimal filtering are extended to visual information acquisition and processing. The goal is to provide a comprehensive methodology for quantitatively assessing the end-to-end performance of image gathering, coding, and processing. (2) Focal-plane processing techniques and technology are developed to combine effectively image gathering with coding. The emphasis is on low-level vision processing akin to the retinal processing in human vision. (3) A breadboard adaptive image-coding system is being assembled. This system will be used to develop and evaluate a number of advanced image-coding technologies and techniques as well as research the concept of adaptive image coding.

Conjecturing and Generalization Process on The Structural Development

NASA Astrophysics Data System (ADS)

Ni'mah, Khomsatun; Purwanto; Bambang Irawan, Edy; Hidayanto, Erry

2017-06-01

This study aims to describe how conjecturing process and generalization process of structural development to thirty children in middle school at grade 8 in solving problems of patterns. Processing of the data in this study uses qualitative data analysis techniques. The analyzed data is the data obtained through direct observation technique, documentation, and interviews. This study based on research studies Mulligan et al (2012) which resulted in a five - structural development stage, namely prestructural, emergent, partial, structural, and advance. From the analysis of the data in this study found there are two phenomena that is conjecturing and generalization process are related. During the conjecturing process, the childrens appropriately in making hypothesis of patterns problem through two phases, which are numerically and symbolically. Whereas during the generalization of process, the childrens able to related rule of pattern on conjecturing process to another context.

Development of a beam builder for automatic fabrication of large composite space structures

NASA Technical Reports Server (NTRS)

Bodle, J. G.

1979-01-01

The composite material beam builder which will produce triangular beams from pre-consolidated graphite/glass/thermoplastic composite material through automated mechanical processes is presented, side member storage, feed and positioning, ultrasonic welding, and beam cutoff are formed. Each process lends itself to modular subsystem development. Initial development is concentrated on the key processes for roll forming and ultrasonic welding composite thermoplastic materials. The construction and test of an experimental roll forming machine and ultrasonic welding process control techniques are described.

Low cost solar array project: Experimental process system development unit for producing semiconductor-grade silicon using silane-to-silicon process

NASA Technical Reports Server (NTRS)

1980-01-01

The design, fabrication, and installation of an experimental process system development unit (EPSDU) were analyzed. Supporting research and development were performed to provide an information data base usable for the EPSDU and for technological design and economical analysis for potential scale-up of the process. Iterative economic analyses were conducted for the estimated product cost for the production of semiconductor grade silicon in a facility capable of producing 1000-MT/Yr.

Women Education and Economic Development in Kenya: Implications for Curriculum Development and Implementation Processes

ERIC Educational Resources Information Center

Syomwene, Anne; Kindiki, Jonah Nyaga

2015-01-01

This paper is a discussion of the relationship between women education and sustainable economic development in Kenya and its implications for curriculum development and implementation processes. The argument advanced in this paper is that the solution to the development problems in Kenya and other developing nations lies on women education.…

Big Data Analysis of Manufacturing Processes

NASA Astrophysics Data System (ADS)

Windmann, Stefan; Maier, Alexander; Niggemann, Oliver; Frey, Christian; Bernardi, Ansgar; Gu, Ying; Pfrommer, Holger; Steckel, Thilo; Krüger, Michael; Kraus, Robert

2015-11-01

The high complexity of manufacturing processes and the continuously growing amount of data lead to excessive demands on the users with respect to process monitoring, data analysis and fault detection. For these reasons, problems and faults are often detected too late, maintenance intervals are chosen too short and optimization potential for higher output and increased energy efficiency is not sufficiently used. A possibility to cope with these challenges is the development of self-learning assistance systems, which identify relevant relationships by observation of complex manufacturing processes so that failures, anomalies and need for optimization are automatically detected. The assistance system developed in the present work accomplishes data acquisition, process monitoring and anomaly detection in industrial and agricultural processes. The assistance system is evaluated in three application cases: Large distillation columns, agricultural harvesting processes and large-scale sorting plants. In this paper, the developed infrastructures for data acquisition in these application cases are described as well as the developed algorithms and initial evaluation results.

Kennedy Space Center Launch and Landing Support

NASA Technical Reports Server (NTRS)

Wahlberg, Jennifer

2010-01-01

The presentations describes Kennedy Space Center (KSC) payload processing, facilities and capabilities, and research development and life science experience. Topics include launch site processing, payload processing, key launch site processing roles, leveraging KSC experience, Space Station Processing Facility and capabilities, Baseline Data Collection Facility, Space Life Sciences Laboratory and capabilities, research payload development, International Space Station research flight hardware, KSC flight payload history, and KSC life science expertise.

Emerging freeze-drying process development and scale-up issues.

PubMed

Patel, Sajal Manubhai; Pikal, Michael J

2011-03-01

Although several guidelines do exist for freeze-drying process development and scale-up, there are still a number of issues that require additional attention. The objective of this review article is to discuss some emerging process development and scale-up issue with emphasis on effect of load condition and freeze-drying in novel container systems such as syringes, Lyoguard trays, ampoules, and 96-well plates. Understanding the heat and mass transfer under different load conditions and for freeze-drying in these novel container systems will help in developing a robust freeze-drying process which is also easier to scale-up. Further research and development needs in these emerging areas have also been addressed. © 2011 American Association of Pharmaceutical Scientists

Optimization of Primary Drying in Lyophilization during Early Phase Drug Development using a Definitive Screening Design with Formulation and Process Factors.

PubMed

Goldman, Johnathan M; More, Haresh T; Yee, Olga; Borgeson, Elizabeth; Remy, Brenda; Rowe, Jasmine; Sadineni, Vikram

2018-06-08

Development of optimal drug product lyophilization cycles is typically accomplished via multiple engineering runs to determine appropriate process parameters. These runs require significant time and product investments, which are especially costly during early phase development when the drug product formulation and lyophilization process are often defined simultaneously. Even small changes in the formulation may require a new set of engineering runs to define lyophilization process parameters. In order to overcome these development difficulties, an eight factor definitive screening design (DSD), including both formulation and process parameters, was executed on a fully human monoclonal antibody (mAb) drug product. The DSD enables evaluation of several interdependent factors to define critical parameters that affect primary drying time and product temperature. From these parameters, a lyophilization development model is defined where near optimal process parameters can be derived for many different drug product formulations. This concept is demonstrated on a mAb drug product where statistically predicted cycle responses agree well with those measured experimentally. This design of experiments (DoE) approach for early phase lyophilization cycle development offers a workflow that significantly decreases the development time of clinically and potentially commercially viable lyophilization cycles for a platform formulation that still has variable range of compositions. Copyright © 2018. Published by Elsevier Inc.

An exploratory survey of methods used to develop measures of performance

NASA Astrophysics Data System (ADS)

Hamner, Kenneth L.; Lafleur, Charles A.

1993-09-01

Nonmanufacturing organizations are being challenged to provide high-quality products and services to their customers, with an emphasis on continuous process improvement. Measures of performance, referred to as metrics, can be used to foster process improvement. The application of performance measurement to nonmanufacturing processes can be very difficult. This research explored methods used to develop metrics in nonmanufacturing organizations. Several methods were formally defined in the literature, and the researchers used a two-step screening process to determine the OMB Generic Method was most likely to produce high-quality metrics. The OMB Generic Method was then used to develop metrics. A few other metric development methods were found in use at nonmanufacturing organizations. The researchers interviewed participants in metric development efforts to determine their satisfaction and to have them identify the strengths and weaknesses of, and recommended improvements to, the metric development methods used. Analysis of participants' responses allowed the researchers to identify the key components of a sound metrics development method. Those components were incorporated into a proposed metric development method that was based on the OMB Generic Method, and should be more likely to produce high-quality metrics that will result in continuous process improvement.

Professional Development Priorities Process (Needs Assessment). Leader's Handbook.

ERIC Educational Resources Information Center

Southeast Idaho Teacher Center Consortium, Twin Falls.

Step-by-step instructions are provided for implementing the Professional Development Priorities Process (PDPP), an educational needs assessment process, by a school faculty member with groups of eight peers or more. The essence of PDPP, which was designed at the Southeast Idaho Teacher Center Consortium, is a dynamic group process in which needs…

Challenges of Engaging Local Stakeholders for Statewide Program Development Process

ERIC Educational Resources Information Center

Martin, Michael J.; Leuci, Mary; Stewart, Mark

2014-01-01

The University of Missouri Extension needed to develop an annual program review process that collaboratively engaged county-level stakeholders. The results from the first 2 years highlight the results, challenges, and implications of the design process. The annual review process needs to be adaptive, responsive, and reflective from year to year…

The Development of Verbal and Visual Working Memory Processes: A Latent Variable Approach

ERIC Educational Resources Information Center

Koppenol-Gonzalez, Gabriela V.; Bouwmeester, Samantha; Vermunt, Jeroen K.

2012-01-01

Working memory (WM) processing in children has been studied with different approaches, focusing on either the organizational structure of WM processing during development (factor analytic) or the influence of different task conditions on WM processing (experimental). The current study combined both approaches, aiming to distinguish verbal and…

Basic Auditory Processing Skills and Phonological Awareness in Low-IQ Readers and Typically Developing Controls

ERIC Educational Resources Information Center

Kuppen, Sarah; Huss, Martina; Fosker, Tim; Fegan, Natasha; Goswami, Usha

2011-01-01

We explore the relationships between basic auditory processing, phonological awareness, vocabulary, and word reading in a sample of 95 children, 55 typically developing children, and 40 children with low IQ. All children received nonspeech auditory processing tasks, phonological processing and literacy measures, and a receptive vocabulary task.…

Climate Action Planning Process | Climate Neutral Research Campuses | NREL

Science.gov Websites

Action Planning Process Climate Action Planning Process For research campuses, NREL has developed a five-step process to develop and implement climate action plans: Determine baseline energy consumption Analyze technology options Prepare a plan and set priorities Implement the climate action plan Measure and

Looking for Synergies: Education for Sustainable Development and the Bologna Process

ERIC Educational Resources Information Center

Fadeeva, Zinaida; Galkute, Laima

2012-01-01

In defining quality of higher education, competences achieved by graduates are interpreted as essential criteria. There are two political processes in education dealing, among other issues, with competence development: the Bologna Process in European Higher Education Area and a global process--the United Nations (UN) Decade (2005-2014) of…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zitney, S.E.; McCorkle, D.; Yang, C.

Process modeling and simulation tools are widely used for the design and operation of advanced power generation systems. These tools enable engineers to solve the critical process systems engineering problems that arise throughout the lifecycle of a power plant, such as designing a new process, troubleshooting a process unit or optimizing operations of the full process. To analyze the impact of complex thermal and fluid flow phenomena on overall power plant performance, the Department of Energy’s (DOE) National Energy Technology Laboratory (NETL) has developed the Advanced Process Engineering Co-Simulator (APECS). The APECS system is an integrated software suite that combinesmore » process simulation (e.g., Aspen Plus) and high-fidelity equipment simulations such as those based on computational fluid dynamics (CFD), together with advanced analysis capabilities including case studies, sensitivity analysis, stochastic simulation for risk/uncertainty analysis, and multi-objective optimization. In this paper we discuss the initial phases of the integration of the APECS system with the immersive and interactive virtual engineering software, VE-Suite, developed at Iowa State University and Ames Laboratory. VE-Suite uses the ActiveX (OLE Automation) controls in the Aspen Plus process simulator wrapped by the CASI library developed by Reaction Engineering International to run process/CFD co-simulations and query for results. This integration represents a necessary step in the development of virtual power plant co-simulations that will ultimately reduce the time, cost, and technical risk of developing advanced power generation systems.« less

ASRM process development in aqueous cleaning

NASA Technical Reports Server (NTRS)

Swisher, Bill

1992-01-01

Viewgraphs are included on process development in aqueous cleaning which is taking place at the Aerojet Advanced Solid Rocket Motor (ASRM) Division under a NASA Marshall Space and Flight Center contract for design, development, test, and evaluation of the ASRM including new production facilities. The ASRM will utilize aqueous cleaning in several manufacturing process steps to clean case segments, nozzle metal components, and igniter closures. ASRM manufacturing process development is underway, including agent selection, agent characterization, subscale process optimization, bonding verification, and scale-up validation. Process parameters are currently being tested for optimization utilizing a Taguci Matrix, including agent concentration, cleaning solution temperature, agitation and immersion time, rinse water amount and temperature, and use/non-use of drying air. Based on results of process development testing to date, several observations are offered: aqueous cleaning appears effective for steels and SermeTel-coated metals in ASRM processing; aqueous cleaning agents may stain and/or attack bare aluminum metals to various extents; aqueous cleaning appears unsuitable for thermal sprayed aluminum-coated steel; aqueous cleaning appears to adequately remove a wide range of contaminants from flat metal surfaces, but supplementary assistance may be needed to remove clumps of tenacious contaminants embedded in holes, etc.; and hot rinse water appears to be beneficial to aid in drying of bare steel and retarding oxidation rate.

Novel shortcut estimation method for regeneration energy of amine solvents in an absorption-based carbon capture process.

PubMed

Kim, Huiyong; Hwang, Sung June; Lee, Kwang Soon

2015-02-03

Among various CO2 capture processes, the aqueous amine-based absorption process is considered the most promising for near-term deployment. However, the performance evaluation of newly developed solvents still requires complex and time-consuming procedures, such as pilot plant tests or the development of a rigorous simulator. Absence of accurate and simple calculation methods for the energy performance at an early stage of process development has lengthened and increased expense of the development of economically feasible CO2 capture processes. In this paper, a novel but simple method to reliably calculate the regeneration energy in a standard amine-based carbon capture process is proposed. Careful examination of stripper behaviors and exploitation of energy balance equations around the stripper allowed for calculation of the regeneration energy using only vapor-liquid equilibrium and caloric data. Reliability of the proposed method was confirmed by comparing to rigorous simulations for two well-known solvents, monoethanolamine (MEA) and piperazine (PZ). The proposed method can predict the regeneration energy at various operating conditions with greater simplicity, greater speed, and higher accuracy than those proposed in previous studies. This enables faster and more precise screening of various solvents and faster optimization of process variables and can eventually accelerate the development of economically deployable CO2 capture processes.

Materials Genome Initiative

NASA Technical Reports Server (NTRS)

Vickers, John

2015-01-01

The Materials Genome Initiative (MGI) project element is a cross-Center effort that is focused on the integration of computational tools to simulate manufacturing processes and materials behavior. These computational simulations will be utilized to gain understanding of processes and materials behavior to accelerate process development and certification to more efficiently integrate new materials in existing NASA projects and to lead to the design of new materials for improved performance. This NASA effort looks to collaborate with efforts at other government agencies and universities working under the national MGI. MGI plans to develop integrated computational/experimental/ processing methodologies for accelerating discovery and insertion of materials to satisfy NASA's unique mission demands. The challenges include validated design tools that incorporate materials properties, processes, and design requirements; and materials process control to rapidly mature emerging manufacturing methods and develop certified manufacturing processes

A Qualitative Study of Latino Lesbian and Gay Youths' Experiences with Discrimination and the Career Development Process

ERIC Educational Resources Information Center

Adams, Eve M.; Cahill, Betsy J.; Ackerlind, Stacy J.

2005-01-01

Eight Latino lesbian and gay (LG) youth were interviewed for this descriptive qualitative study. The purpose of this study was to examine the Latino LG youth career development process and to increase our understanding of how multiple identities intersect with each other and the career development process. Six themes emerged: knowing you are…

European Science Notes Information Bulletin Reports on Current European and Middle Eastern Science

DTIC Science & Technology

1992-01-01

Overcash MATERIALS Research and Development in the Abbey-Polymer Processing and Properties ................... 574 J. Magill Corrosion and Protection Centre...gressi• ely pursuing the development of powerful "* Software Engineering and microprocessors and communication chips. The Information Processing ...differential equations, processing , Europe has a number of fascinating weather forecasting) that are to be developed by a projects in distributed

Rapid Development: A Content Analysis Comparison of Literature and Purposive Sampling of AFRL Rapid Reaction Projects

DTIC Science & Technology

2011-12-01

systems engineering technical and technical management processes. Technical Planning, Stakeholders Requirements Development, and Architecture Design were...Stakeholder Requirements Definition, Architecture Design and Technical Planning. A purposive sampling of AFRL rapid development program managers and engineers...emphasize one process over another however Architecture Design , Implementation scored higher among Technical Processes. Decision Analysis, Technical

New Product Development (NPD) Process - An Example of Industrial Sector

NASA Astrophysics Data System (ADS)

Kazimierska, Marianna; Grębosz-Krawczyk, Magdalena

2017-12-01

This aim of this article is to present the process of new product introduction on example of industrial sector in context of new product development (NPD) concept. In the article, the concept of new product development is discussed and the different stages of the process of new electric motor development are analysed taking into account its objectives, implemented procedures, functions and responsibilities division. In the article, information from secondary sources and the results of empirical research - conducted in an international manufacturing company - are used. The research results show the significance of project leader and regular cooperation with final client in the NPD process.

PVD thermal barrier coating applications and process development for aircraft engines

NASA Astrophysics Data System (ADS)

Rigney, D. V.; Viguie, R.; Wortman, D. J.; Skelly, D. W.

1997-06-01

Thermal barrier coatings (TBCs) have been developed for application to aircraft engine components to improve service life in an increasingly hostile thermal environment. The choice of TBC type is related to the component, intended use, and economics. Selection of electron beam physical vapor deposition proc-essing for turbine blade is due in part to part size, surface finish requirements, thickness control needs, and hole closure issues. Process development of PVD TBCs has been carried out at several different sites, including GE Aircraft Engines (GEAE). The influence of processing variables on microstructure is dis-cussed, along with the GEAE development coater and initial experiences of pilot line operation.

Process wastewater treatability study for Westinghouse fluidized-bed coal gasification

DOE Office of Scientific and Technical Information (OSTI.GOV)

Winton, S.L.; Buvinger, B.J.; Evans, J.M.

1983-11-01

In the development of a synthetic fuels facility, water usage and wastewater treatment are major areas of concern. Coal gasification processes generally produce relatively large volumes of gas condensates. These wastewaters are typically composed of a variety of suspended and dissolved organic and inorganic solids and dissolved gaseous contaminants. Fluidized-bed coal gasification (FBG) processes are no exception to this rule. The Department of Energy's Morgantown Energy Technology Center (METC), the Gas Research Institute (GRI), and the Environmental Protection Agency (EPA/IERLRTP) recognized the need for a FBG treatment program to provide process design data for FBG wastewaters during the environmental, health,more » and safety characterization of the Westinghouse Process Development Unit (PDU). In response to this need, METC developed conceptual designs and a program plan to obtain process design and performance data for treating wastewater from commercial-scale Westinghouse-based synfuels plants. As a result of this plan, METC, GRI, and EPA entered into a joint program to develop performance data, design parameters, conceptual designs, and cost estimates for treating wastewaters from a FBG plant. Wastewater from the Westinghouse PDU consists of process quench and gas cooling condensates which are similar to those produced by other FBG processes such as U-Gas, and entrained-bed gasification processes such as Texaco. Therefore, wastewater from this facility was selected as the basis for this study. This paper outlines the current program for developing process design and cost data for the treatment of these wastewaters.« less

A model for process representation and synthesis. Ph.D. Thesis

NASA Technical Reports Server (NTRS)

Thomas, R. H.

1971-01-01

The problem of representing groups of loosely connected processes is investigated, and a model for process representation useful for synthesizing complex patterns of process behavior is developed. There are three parts, the first part isolates the concepts which form the basis for the process representation model by focusing on questions such as: What is a process; What is an event; Should one process be able to restrict the capabilities of another? The second part develops a model for process representation which captures the concepts and intuitions developed in the first part. The model presented is able to describe both the internal structure of individual processes and the interface structure between interacting processes. Much of the model's descriptive power derives from its use of the notion of process state as a vehicle for relating the internal and external aspects of process behavior. The third part demonstrates by example that the model for process representation is a useful one for synthesizing process behavior patterns. In it the model is used to define a variety of interesting process behavior patterns. The dissertation closes by suggesting how the model could be used as a semantic base for a very potent language extension facility.

A Latent Variables Examination of Processing Speed, Response Inhibition, and Working Memory during Typical Development

PubMed Central

McAuley, Tara; White, Desirée

2010-01-01

The present study addressed three related aims: (1) to replicate and extend previous work regarding the non-unitary nature of processing speed, response inhibition, and working memory during development, (2) to quantify the rate at which processing speed, response inhibition, and working memory develop and the extent to which the development of these latter abilities reflect general changes in processing speed, and (3) to evaluate whether commonly used tasks of processing speed, response inhibition, and working memory are valid and reliable when used with a developmentally diverse group. To address these aims, a latent variables approach was used to analyze data from 147 participants 6 to 24 years of age. Results showed that processing speed, response inhibition, and working memory were separable abilities and that the extent of this separability was stable cross the age range of participants. All three constructs improved as a function of age; however, only the effect of age on working memory remained significant after processing speed was controlled. The psychometric properties of tasks used to assess the constructs were age invariant, thus validating their use in studies of executive development. PMID:20888572

Diversity of thermophilic populations during thermophilic aerobic digestion of potato peel slurry.

PubMed

Ugwuanyi, J O; Harvey, L M; McNeil, B

2008-01-01

To study the diversity of thermophiles during thermophilic aerobic digestion (TAD) of agro-food waste slurries under conditions similar to full-scale processes. Population diversity and development in TAD were studied by standard microbiological techniques and the processes monitored by standard fermentation procedures. Facultative thermophiles were identified as Bacillus coagulans and B. licheniformis, while obligate thermophiles were identified as B. stearothermophilus. They developed rapidly to peaks of 10(7) to 10(8) in

Goal setting with mothers in child development services.

PubMed

Forsingdal, S; St John, W; Miller, V; Harvey, A; Wearne, P

2014-07-01

The aim of this grounded theory study was to explore mothers' perspectives of the processes of collaborative goal setting in multidisciplinary child development services involving follow-up home therapy. Semi-structured interviews were conducted in South East Queensland, Australia with 14 mothers of children aged 3-6 years who were accessing multidisciplinary child development services. Interviews were focussed around the process of goal setting. A grounded theory of Maternal Roles in Goal Setting (The M-RIGS Model) was developed from analysis of data. Mothers assumed Dependent, Active Participator and Collaborator roles when engaging with the therapist in goal-setting processes. These roles were characterized by the mother's level of dependence on the therapist and insight into their child's needs and therapy processes. Goal Factors, Parent Factors and Therapist Factors influenced and added complexity to the goal-setting process. The M-RIGS Model highlights that mothers take on a range of roles in the goal-setting process. Although family-centred practice encourages negotiation and collaborative goal setting, parents may not always be ready to take on highly collaborative roles. Better understanding of parent roles, goal-setting processes and influencing factors will inform better engagement with families accessing multidisciplinary child development services. © 2013 John Wiley & Sons Ltd.

From Discovery to Production: Biotechnology of Marine Fungi for the Production of New Antibiotics.

PubMed

Silber, Johanna; Kramer, Annemarie; Labes, Antje; Tasdemir, Deniz

2016-07-21

Filamentous fungi are well known for their capability of producing antibiotic natural products. Recent studies have demonstrated the potential of antimicrobials with vast chemodiversity from marine fungi. Development of such natural products into lead compounds requires sustainable supply. Marine biotechnology can significantly contribute to the production of new antibiotics at various levels of the process chain including discovery, production, downstream processing, and lead development. However, the number of biotechnological processes described for large-scale production from marine fungi is far from the sum of the newly-discovered natural antibiotics. Methods and technologies applied in marine fungal biotechnology largely derive from analogous terrestrial processes and rarely reflect the specific demands of the marine fungi. The current developments in metabolic engineering and marine microbiology are not yet transferred into processes, but offer numerous options for improvement of production processes and establishment of new process chains. This review summarises the current state in biotechnological production of marine fungal antibiotics and points out the enormous potential of biotechnology in all stages of the discovery-to-development pipeline. At the same time, the literature survey reveals that more biotechnology transfer and method developments are needed for a sustainable and innovative production of marine fungal antibiotics.

Process development and tooling design for intrinsic hybrid composites

NASA Astrophysics Data System (ADS)

Riemer, M.; Müller, R.; Drossel, W. G.; Landgrebe, D.

2017-09-01

Hybrid parts, which combine the advantages of different material classes, are moving into the focus of lightweight applications. This development is amplified by their high potential for usage in the field of crash relevant structures. By the current state of the art, hybrid parts are mainly made in separate, subsequent forming and joining processes. By using the concept of an intrinsic hybrid, the shaping of the part and the joining of the different materials are performed in a single process step for shortening the overall processing time and thereby the manufacturing costs. The investigated hybrid part is made from continuous fibre reinforced plastic (FRP), in which a metallic reinforcement structure is integrated. The connection between these layered components is realized by a combination of adhesive bonding and a geometrical form fit. The form fit elements are intrinsically generated during the forming process. This contribution regards the development of the forming process and the design of the forming tool for the single step production of a hybrid part. To this end a forming tool, which combines the thermo-forming and the metal forming process, is developed. The main challenge by designing the tool is the temperature management of the tool elements for the variothermal forming process. The process parameters are determined in basic tests and finite element (FE) simulation studies. On the basis of these investigations a control concept for the steering of the motion axes and the tool temperature is developed. Forming tests are carried out with the developed tool and the manufactured parts are analysed by computer assisted tomography (CT) scans.

The Building Wellness project: a case history of partnership, power sharing, and compromise.

PubMed

Jones, Drew; Franklin, Charla; Butler, Brittany T; Williams, Pluscedia; Wells, Kenneth B; Rodríguez, Michael A

2006-01-01

The Institute of Medicine has recommended development of community-focused strategies to alleviate the disproportionate burden of illness on minorities, including depression. So far, limited data exist on the process of developing such partnerships within diverse racial/ethnic environments as they strive to develop community-driven, evidence-based action plans to improve the quality of outreach services. We describe such an effort around depression in south Los Angeles and explore the issues of the process in the hopes of informing future partnership development. Community meetings, presentations, feedback, discussion groups, and consensus-based action items were implemented over an 18-month period. A writing subcommittee was designated to develop a description of the group's work and process, as well as the diverse perspectives in the partnership. Data sources included meeting minutes, materials for members and community feedback presentations, scribe notes, and the reflections of the authors. Development was seen on the formal group level, in the process, and on the realization of three categories of action plans. Designed to assist social service caseworkers in the recognition of and referral for depression, the action plans included developing a website, a tool kit (modified Delphi process), and a one-page depression "fact sheet" with region-specific referrals. Through the process of developing a means to combat depression in a racially/ ethnically diverse population, the community is not only better informed about depression but has become a true partner with the academic element in adapting these programs for local service providers, resulting in improved understanding of the partnership process.

The Role of the University in the Development Process of Less Developed Countries

ERIC Educational Resources Information Center

Tinbergen, J.

1978-01-01

The role of the university in the development process must be dealt with in an environment of widespread great poverty characteristic of the larger part of the developing world. Focuses on development policy and the satisfaction of human basic needs as the highest priority for the university. (Author/RK)

24 CFR 972.133 - Public and resident consultation process for developing a conversion plan.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 4 2012-04-01 2012-04-01 false Public and resident consultation process for developing a conversion plan. 972.133 Section 972.133 Housing and Urban Development... ASSISTANCE Required Conversion of Public Housing Developments Conversion Plans § 972.133 Public and resident...

Professional Development Sites: Revitalizing Preservice Education in Middle Schools.

ERIC Educational Resources Information Center

Bell, Nancy M.

This case study reports on the experiences of teachers and student teachers during the process of developing and implementing professional development sites (PDSs) at one urban and two rural middle schools. The study examines the phases of development that teachers go through in the process of developing PDSs and how teachers' level of development…

Recovery of Uranium from Wet Phosphoric Acid by Solvent Extraction Processes

DOE PAGES

Beltrami, Denis; Cote, Gérard; Mokhtari, Hamid; ...

2014-11-17

Between 1951 and 1991, we developed about 17 processes to recover uranium from wet phosphoric acid (WPA), but the viability of these processes was subject to the variation of the uranium price market. Nowadays, uranium from WPA appears to be attractive due to the increase of the global uranium demand resulting from the emergence of developing countries. Moreover, the increasing demand provides impetus for a new look at the applicable technology with a view to improvements as well as altogether new approaches. This paper gives an overview on extraction processes developed in the past to recover uranium from wet phosphoricmore » acid (WPA) as well as the physicochemistry involved in these processes. Recent advances concerning the development of new extraction systems are also reported and discussed.« less

Commercialization of Ultra-Hard Ceramics for Cutting Tools Final Report CRADA No. TC0279.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Landingham, R.; Neumann, T.

This was a collaborative effort between Lawrence Livermore National Security, LLC as manager and operator of Lawrence Livermore National Laboratory (LLNL) and Greenleaf Corporation (Greenleaf) to develop the technology for forming unique precursor nano-powders process that can be consolidated into ceramic products for industry. LLNL researchers have developed a solgel process for forming nano-ceramic powders. The nano powders are highly tailorable, allowing the explicit design of desired properties that lead to ultra hard materials with fine grain size. The present CRADA would allow the two parties to continue the development of the sol-gel process and the consolidation process in ordermore » to develop an industrially sound process for the manufacture of these ultra-hard materials.« less

The development of information processing biases in childhood anxiety: a review and exploration of its origins in parenting.

PubMed

Hadwin, Julie A; Garner, Matthew; Perez-Olivas, Gisela

2006-11-01

The aim of this paper is to explore parenting as one potential route through which information processing biases for threat develop in children. It reviews information processing biases in childhood anxiety in the context of theoretical models and empirical research in the adult anxiety literature. Specifically, it considers how adult models have been used and adapted to develop a theoretical framework with which to investigate information processing biases in children. The paper then considers research which specifically aims to understand the relationship between parenting and the development of information processing biases in children. It concludes that a clearer theoretical framework is required to understand the significance of information biases in childhood anxiety, as well as their origins in parenting.

Designing Training Materials for Developing Countries.

ERIC Educational Resources Information Center

Rosenweig, Fred

1984-01-01

Describes four training guides developed by the Water and Sanitation for Health Project for use in rural water supply and sanitation projects in developing countries, explains the development process, offers insights gained from the process, and presents five considerations for designing training in third world countries. (MBR)

24 CFR 581.9 - Application process.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 3 2013-04-01 2013-04-01 false Application process. 581.9 Section 581.9 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF HOUSING AND URBAN...

24 CFR 581.9 - Application process.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Application process. 581.9 Section 581.9 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF HOUSING AND URBAN...

24 CFR 581.9 - Application process.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 3 2012-04-01 2012-04-01 false Application process. 581.9 Section 581.9 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF HOUSING AND URBAN...

24 CFR 581.9 - Application process.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 3 2014-04-01 2013-04-01 true Application process. 581.9 Section 581.9 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF HOUSING AND URBAN...

24 CFR 581.9 - Application process.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 3 2011-04-01 2010-04-01 true Application process. 581.9 Section 581.9 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF HOUSING AND URBAN...

How inverse solver technologies can support die face development and process planning in the automotive industry

NASA Astrophysics Data System (ADS)

Huhn, Stefan; Peeling, Derek; Burkart, Maximilian

2017-10-01

With the availability of die face design tools and incremental solver technologies to provide detailed forming feasibility results in a timely fashion, the use of inverse solver technologies and resulting process improvements during the product development process of stamped parts often is underestimated. This paper presents some applications of inverse technologies that are currently used in the automotive industry to streamline the product development process and greatly increase the quality of a developed process and the resulting product. The first focus is on the so-called target strain technology. Application examples will show how inverse forming analysis can be applied to support the process engineer during the development of a die face geometry for Class `A' panels. The drawing process is greatly affected by the die face design and the process designer has to ensure that the resulting drawn panel will meet specific requirements regarding surface quality and a minimum strain distribution to ensure dent resistance. The target strain technology provides almost immediate feedback to the process engineer during the die face design process if a specific change of the die face design will help to achieve these specific requirements or will be counterproductive. The paper will further show how an optimization of the material flow can be achieved through the use of a newly developed technology called Sculptured Die Face (SDF). The die face generation in SDF is more suited to be used in optimization loops than any other conventional die face design technology based on cross section design. A second focus in this paper is on the use of inverse solver technologies for secondary forming operations. The paper will show how the application of inverse technology can be used to accurately and quickly develop trim lines on simple as well as on complex support geometries.

Application of agent-based system for bioprocess description and process improvement.

PubMed

Gao, Ying; Kipling, Katie; Glassey, Jarka; Willis, Mark; Montague, Gary; Zhou, Yuhong; Titchener-Hooker, Nigel J

2010-01-01

Modeling plays an important role in bioprocess development for design and scale-up. Predictive models can also be used in biopharmaceutical manufacturing to assist decision-making either to maintain process consistency or to identify optimal operating conditions. To predict the whole bioprocess performance, the strong interactions present in a processing sequence must be adequately modeled. Traditionally, bioprocess modeling considers process units separately, which makes it difficult to capture the interactions between units. In this work, a systematic framework is developed to analyze the bioprocesses based on a whole process understanding and considering the interactions between process operations. An agent-based approach is adopted to provide a flexible infrastructure for the necessary integration of process models. This enables the prediction of overall process behavior, which can then be applied during process development or once manufacturing has commenced, in both cases leading to the capacity for fast evaluation of process improvement options. The multi-agent system comprises a process knowledge base, process models, and a group of functional agents. In this system, agent components co-operate with each other in performing their tasks. These include the description of the whole process behavior, evaluating process operating conditions, monitoring of the operating processes, predicting critical process performance, and providing guidance to decision-making when coping with process deviations. During process development, the system can be used to evaluate the design space for process operation. During manufacture, the system can be applied to identify abnormal process operation events and then to provide suggestions as to how best to cope with the deviations. In all cases, the function of the system is to ensure an efficient manufacturing process. The implementation of the agent-based approach is illustrated via selected application scenarios, which demonstrate how such a framework may enable the better integration of process operations by providing a plant-wide process description to facilitate process improvement. Copyright 2009 American Institute of Chemical Engineers

The Impact of City-level Permitting Processes on Residential Photovoltaic Installation Prices and Development Times: An Empirical Analysis of Solar Systems in California Cities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wiser, Ryan; Dong, Changgui

Business process or “soft” costs account for well over 50% of the installed price of residential photovoltaic (PV) systems in the United States, so understanding these costs is crucial for identifying PV cost-reduction opportunities. Among these costs are those imposed by city-level permitting processes, which may add both expense and time to the PV development process. Building on previous research, this study evaluates the effect of city-level permitting processes on the installed price of residential PV systems and on the time required to develop and install those systems. The study uses a unique dataset from the U.S. Department of Energy’smore » Rooftop Solar Challenge Program, which includes city-level permitting process “scores,” plus data from the California Solar Initiative and the U.S. Census. Econometric methods are used to quantify the price and development-time effects of city-level permitting processes on more than 3,000 PV installations across 44 California cities in 2011. Results indicate that city-level permitting processes have a substantial and statistically significant effect on average installation prices and project development times. The results suggest that cities with the most favorable (i.e., highest-scoring) permitting practices can reduce average residential PV prices by $0.27–$0.77/W (4%–12% of median PV prices in California) compared with cities with the most onerous (i.e., lowest-scoring) permitting practices, depending on the regression model used. Though the empirical models for development times are less robust, results suggest that the most streamlined permitting practices may shorten development times by around 24 days on average (25% of the median development time). These findings illustrate the potential price and development-time benefits of streamlining local permitting procedures for PV systems.« less

[Development of Nanotechnology for X-Ray Astronomy Instrumentation

NASA Technical Reports Server (NTRS)

Schattenburg, Mark L.

2004-01-01

This Research Grant provides support for development of nanotechnology for x-ray astronomy instrumentation. MIT has made significant progress in several development areas. In the last year we have made considerable progress in demonstrating the high-fidelity patterning and replication of x-ray reflection gratings. We developed a process for fabricating blazed gratings in silicon with extremely smooth and sharp sawtooth profiles, and developed a nanoimprint process for replication. We also developed sophisticated new fixturing for holding thin optics during metrology without causing distortion. We developed a new image processing algorithm for our Shack-Hartmann tool that uses Zernike polynomials. This has resulted in much more accurate and repeatable measurements on thin optics.

The Knowledge-Based Software Assistant: Beyond CASE

NASA Technical Reports Server (NTRS)

Carozzoni, Joseph A.

1993-01-01

This paper will outline the similarities and differences between two paradigms of software development. Both support the whole software life cycle and provide automation for most of the software development process, but have different approaches. The CASE approach is based on a set of tools linked by a central data repository. This tool-based approach is data driven and views software development as a series of sequential steps, each resulting in a product. The Knowledge-Based Software Assistant (KBSA) approach, a radical departure from existing software development practices, is knowledge driven and centers around a formalized software development process. KBSA views software development as an incremental, iterative, and evolutionary process with development occurring at the specification level.

Domain Modeling and Application Development of an Archetype- and XML-based EHRS. Practical Experiences and Lessons Learnt.

PubMed

Kropf, Stefan; Chalopin, Claire; Lindner, Dirk; Denecke, Kerstin

2017-06-28

Access to patient data within the hospital or between hospitals is still problematic since a variety of information systems is in use applying different vendor specific terminologies and underlying knowledge models. Beyond, the development of electronic health record systems (EHRSs) is time and resource consuming. Thus, there is a substantial need for a development strategy of standardized EHRSs. We are applying a reuse-oriented process model and demonstrate its feasibility and realization on a practical medical use case, which is an EHRS holding all relevant data arising in the context of treatment of tumors of the sella region. In this paper, we describe the development process and our practical experiences. Requirements towards the development of the EHRS were collected by interviews with a neurosurgeon and patient data analysis. For modelling of patient data, we selected openEHR as standard and exploited the software tools provided by the openEHR foundation. The patient information model forms the core of the development process, which comprises the EHR generation and the implementation of an EHRS architecture. Moreover, a reuse-oriented process model from the business domain was adapted to the development of the EHRS. The reuse-oriented process model is a model for a suitable abstraction of both, modeling and development of an EHR centralized EHRS. The information modeling process resulted in 18 archetypes that were aggregated in a template and built the boilerplate of the model driven development. The EHRs and the EHRS were developed by openEHR and W3C standards, tightly supported by well-established XML techniques. The GUI of the final EHRS integrates and visualizes information from various examinations, medical reports, findings and laboratory test results. We conclude that the development of a standardized overarching EHR and an EHRS is feasible using openEHR and W3C standards, enabling a high degree of semantic interoperability. The standardized representation visualizes data and can in this way support the decision process of clinicians.

Image Processing Using a Parallel Architecture.

DTIC Science & Technology

1987-12-01

ENG/87D-25 Abstract This study developed a set o± low level image processing tools on a parallel computer that allows concurrent processing of images...environment, the set of tools offers a significant reduction in the time required to perform some commonly used image processing operations. vI IMAGE...step toward developing these systems, a structured set of image processing tools was implemented using a parallel computer. More important than

Sensitometric comparisons of Insight and Ektaspeed Plus films: effects of chemical developer depletion.

PubMed

Casanova, Marcia Spinelli; Haiter-Neto, Francisco; Bóscolo, Frab Norberto; de Almeida, Solange Maria

2006-01-01

The aim of this study was to compare the sensitometric properties of Insight and Ektaspeed Plus radiographic films manually and automatically processed using fresh and depleted chemical solutions. Ten sets of each type of film were obtained (1 set = 5 films), 5 sets being manually processed and 5 sets being automatically processed. A total of 100 films (50 Ektaspeed Plus and 50 Insight film) were exposed and developed. The first two sets of each film type were developed in fresh chemicals (one set per each type of processing), on the first day of the experiment. The other sets were processed in the same progressively depleted solutions once a week until the end of experiment, which was completed within 4 weeks. Characteristic curves were constructed to compare the sensitometric properties of the films: contrast, latitude and speed. Processing solution depletion had different effects on manually and automatically developed films, which was confirmed by the changes in the form of the characteristic curves in the third week of the automatic processing and fourth week of the manual processing. Ektaspeed Plus showed 11% reduction in contrast values for manual processing and 53% for automatic processing, while Insight contrast values showed a reduction of 25% and 59%, respectively. Insight film, however, showed lesser loss of speed and lesser increase of latitude than Ektaspeed Plus. In conclusion, chemical depletion in automatic film processing was faster than in manual developing. In depleted chemicals, both types of films had an increase in latitude values and a decrease in speed and contrast. Insight was more resistant than Ektaspeed Plus to decrease in speed and latitude when processed using older chemicals, whereas contrast in Ektaspeed Plus was comparatively more stable.

Understanding the effects of time on collaborative learning processes in problem based learning: a mixed methods study.

PubMed

Hommes, J; Van den Bossche, P; de Grave, W; Bos, G; Schuwirth, L; Scherpbier, A

2014-10-01

Little is known how time influences collaborative learning groups in medical education. Therefore a thorough exploration of the development of learning processes over time was undertaken in an undergraduate PBL curriculum over 18 months. A mixed-methods triangulation design was used. First, the quantitative study measured how various learning processes developed within and over three periods in the first 1,5 study years of an undergraduate curriculum. Next, a qualitative study using semi-structured individual interviews focused on detailed development of group processes driving collaborative learning during one period in seven tutorial groups. The hierarchic multilevel analyses of the quantitative data showed that a varying combination of group processes developed within and over the three observed periods. The qualitative study illustrated development in psychological safety, interdependence, potency, group learning behaviour, social and task cohesion. Two new processes emerged: 'transactive memory' and 'convergence in mental models'. The results indicate that groups are dynamic social systems with numerous contextual influences. Future research should thus include time as an important influence on collaborative learning. Practical implications are discussed.

Modeling and Analysis of the Reverse Water Gas Shift Process for In-Situ Propellant Production

NASA Technical Reports Server (NTRS)

Whitlow, Jonathan E.

2000-01-01

This report focuses on the development of mathematical models and simulation tools developed for the Reverse Water Gas Shift (RWGS) process. This process is a candidate technology for oxygen production on Mars under the In-Situ Propellant Production (ISPP) project. An analysis of the RWGS process was performed using a material balance for the system. The material balance is very complex due to the downstream separations and subsequent recycle inherent with the process. A numerical simulation was developed for the RWGS process to provide a tool for analysis and optimization of experimental hardware, which will be constructed later this year at Kennedy Space Center (KSC). Attempts to solve the material balance for the system, which can be defined by 27 nonlinear equations, initially failed. A convergence scheme was developed which led to successful solution of the material balance, however the simplified equations used for the gas separation membrane were found insufficient. Additional more rigorous models were successfully developed and solved for the membrane separation. Sample results from these models are included in this report, with recommendations for experimental work needed for model validation.

A validation study of the 1,2-indandione reagent for operational use in the UK: Part 2 - Optimization of processing conditions.

PubMed

Nicolasora, Niko; Downham, Rory; Dyer, Rachel-May; Hussey, Laura; Luscombe, Aoife; Sears, Vaughn

2018-05-02

This paper contains details of work carried out to identify the most effective processing conditions for the optimized 1,2-indandione/zn formulation developed for use under UK conditions. Using direct measurements of fluorescence taken from test spots of amino acids and eccrine sweat during oven processing, complemented with experiments on real fingermarks, it was established that processing temperatures above 120°C in the oven were detrimental to the fluorescence of the developed mark. Alternative methods of development to oven processing were found to be effective, but less controllable. High levels of humidification were also found to be detrimental to the fluorescence of 1,2-indandione developed marks, and oven processing at 100°C and 0% relative humidity is therefore recommended for further studies. It has also been shown that 1,2-indandione can develop fingermarks at temperatures as low as 20°C, making it a candidate for use at crime scenes. Copyright © 2018. Published by Elsevier B.V.

Micromechanical Machining Processes and their Application to Aerospace Structures, Devices and Systems

NASA Technical Reports Server (NTRS)

Friedrich, Craig R.; Warrington, Robert O.

1995-01-01

Micromechanical machining processes are those micro fabrication techniques which directly remove work piece material by either a physical cutting tool or an energy process. These processes are direct and therefore they can help reduce the cost and time for prototype development of micro mechanical components and systems. This is especially true for aerospace applications where size and weight are critical, and reliability and the operating environment are an integral part of the design and development process. The micromechanical machining processes are rapidly being recognized as a complementary set of tools to traditional lithographic processes (such as LIGA) for the fabrication of micromechanical components. Worldwide efforts in the U.S., Germany, and Japan are leading to results which sometimes rival lithography at a fraction of the time and cost. Efforts to develop processes and systems specific to aerospace applications are well underway.

Modeling Business Processes in Public Administration

NASA Astrophysics Data System (ADS)

Repa, Vaclav

During more than 10 years of its existence business process modeling became a regular part of organization management practice. It is mostly regarded. as a part of information system development or even as a way to implement some supporting technology (for instance workflow system). Although I do not agree with such reduction of the real meaning of a business process, it is necessary to admit that information technologies play an essential role in business processes (see [1] for more information), Consequently, an information system is inseparable from a business process itself because it is a cornerstone of the general basic infrastructure of a business. This fact impacts on all dimensions of business process management. One of these dimensions is the methodology that postulates that the information systems development provide the business process management with exact methods and tools for modeling business processes. Also the methodology underlying the approach presented in this paper has its roots in the information systems development methodology.

The Establishment of a New Friction Stir Welding Process Development Facility at NASA/MSFC

NASA Technical Reports Server (NTRS)

Carter, Robert W.

2009-01-01

Full-scale weld process development is being performed at MSFC to develop the tools, fixtures, and facilities necessary for Ares I production. Full scale development in-house at MSFC fosters technical acuity within the NASA engineering community, and allows engineers to identify and correct tooling and equipment shortcomings before they become problems on the production floor. Finally, while the new weld process development facility is currently being outfitted in support of Ares I development, it has been established to support all future Constellation Program needs. In particular, both the RWT and VWT were sized with the larger Ares V hardware in mind.

Investigation of charge coupled device correlation techniques

NASA Technical Reports Server (NTRS)

Lampe, D. R.; Lin, H. C.; Shutt, T. J.

1978-01-01

Analog Charge Transfer Devices (CTD's) offer unique advantages to signal processing systems, which often have large development costs, making it desirable to define those devices which can be developed for general system's use. Such devices are best identified and developed early to give system's designers some interchangeable subsystem blocks, not requiring additional individual development for each new signal processing system. The objective of this work is to describe a discrete analog signal processing device with a reasonably broad system use and to implement its design, fabrication, and testing.

HARM processing techniques for MEMS and MOEMS devices using bonded SOI substrates and DRIE

NASA Astrophysics Data System (ADS)

Gormley, Colin; Boyle, Anne; Srigengan, Viji; Blackstone, Scott C.

2000-08-01

Silicon-on-Insulator (SOI) MEMS devices (1) are rapidly gaining popularity in realizing numerous solutions for MEMS, especially in the optical and inertia application fields. BCO recently developed a DRIE trench etch, utilizing the Bosch process, and refill process for high voltage dielectric isolation integrated circuits on thick SOI substrates. In this paper we present our most recently developed DRIE processes for MEMS and MOEMS devices. These advanced etch techniques are initially described and their integration with silicon bonding demonstrated. This has enabled process flows that are currently being utilized to develop optical router and filter products for fiber optics telecommunications and high precision accelerometers.

Quality-by-Design (QbD): An integrated process analytical technology (PAT) approach for a dynamic pharmaceutical co-precipitation process characterization and process design space development.

PubMed

Wu, Huiquan; White, Maury; Khan, Mansoor A

2011-02-28

The aim of this work was to develop an integrated process analytical technology (PAT) approach for a dynamic pharmaceutical co-precipitation process characterization and design space development. A dynamic co-precipitation process by gradually introducing water to the ternary system of naproxen-Eudragit L100-alcohol was monitored at real-time in situ via Lasentec FBRM and PVM. 3D map of count-time-chord length revealed three distinguishable process stages: incubation, transition, and steady-state. The effects of high risk process variables (slurry temperature, stirring rate, and water addition rate) on both derived co-precipitation process rates and final chord-length-distribution were evaluated systematically using a 3(3) full factorial design. Critical process variables were identified via ANOVA for both transition and steady state. General linear models (GLM) were then used for parameter estimation for each critical variable. Clear trends about effects of each critical variable during transition and steady state were found by GLM and were interpreted using fundamental process principles and Nyvlt's transfer model. Neural network models were able to link process variables with response variables at transition and steady state with R(2) of 0.88-0.98. PVM images evidenced nucleation and crystal growth. Contour plots illustrated design space via critical process variables' ranges. It demonstrated the utility of integrated PAT approach for QbD development. Published by Elsevier B.V.

Impact of the Bologna Process on Turkish Higher Education: The Case of Izmir University of Economics

ERIC Educational Resources Information Center

Esen, Oguz; Gürleyen, Isik; Binatli, Ayla Ogus

2012-01-01

This article focuses on Turkey's experience of the Bologna Process. Its main objective is to contribute to the literature on the impact of Bologna Process on national higher education systems regarding the issue of curricula development. It argues that the Bologna Process has fostered development of transparent and systematic curricula, which…

Institutional Planning as a Participative Process: A Community College Self Study.

ERIC Educational Resources Information Center

Sturtz, Alan J.

In 1981, South Central Community College received funding to develop a long-range planning process. The process was to be modeled on the 3-year planning cycle developed by the National Center for Higher Education Management Systems and to use the college's existing organizational structure. Since November 1981, the planning process at the college…

The standards process: X3 information processing systems

NASA Technical Reports Server (NTRS)

Emard, Jean-Paul

1993-01-01

The topics are presented in viewgraph form and include the following: International Organization for Standards (ISO); International Electrotechnical Committee (IEC); ISO/IEC Joint Technical Committee 1 (JTC-1); U.S. interface to JTC-1; ANSI; national organizations; U.S. standards development processes; national and international standards developing organizations; regional organizations; and X3 information processing systems.

Learning Processes of Students in Pre-Vocational Secondary Education: Relations between Goal Orientations, Information Processing Strategies and Development of Conceptual Knowledge

ERIC Educational Resources Information Center

Koopman, Maaike; Den Brok, Perry; Beijaard, Douwe; Teune, Peter

2011-01-01

The purpose of this study was to investigate relations between goal orientations, information processing strategies and development of conceptual knowledge of pre-vocational secondary education students (n = 719; 14 schools). Students' preferences for certain types of goals and information processing strategies were examined using questionnaires.…

Welding Development: Marshall Space Flight Center

NASA Technical Reports Server (NTRS)

Ding, Jeff

2007-01-01

This paper presents the basic understanding of the friction stir welding process. It covers process description, pin tool operation and materials, metal flow theory, mechanical properties, and materials welded using the process. It also discusses the thermal stir welding process and the differences between thermal stir and friction stir welding. MSFC weld tools used for development are also presented.

Study of residue type defect formation mechanism and the effect of advanced defect reduction (ADR) rinse process

NASA Astrophysics Data System (ADS)

Arima, Hiroshi; Yoshida, Yuichi; Yoshihara, Kosuke; Shibata, Tsuyoshi; Kushida, Yuki; Nakagawa, Hiroki; Nishimura, Yukio; Yamaguchi, Yoshikazu

2009-03-01

Residue type defect is one of yield detractors in lithography process. It is known that occurrence of the residue type defect is dependent on resist development process and the defect is reduced by optimized rinsing condition. However, the defect formation is affected by resist materials and substrate conditions. Therefore, it is necessary to optimize the development process condition by each mask level. Those optimization steps require a large amount of time and effort. The formation mechanism is investigated from viewpoint of both material and process. The defect formation is affected by resist material types, substrate condition and development process condition (D.I.W. rinse step). Optimized resist formulation and new rinse technology significantly reduce the residue type defect.

Software Development and Test Methodology for a Distributed Ground System

NASA Technical Reports Server (NTRS)

Ritter, George; Guillebeau, Pat; McNair, Ann R. (Technical Monitor)

2002-01-01

The Marshall Space Flight Center's (MSFC) Payload Operations Center (POC) ground system has evolved over a period of about 10 years. During this time the software processes have migrated from more traditional to more contemporary development processes in an effort to minimize unnecessary overhead while maximizing process benefits. The Software processes that have evolved still emphasize requirements capture, software configuration management, design documenting, and making sure the products that have been developed are accountable to initial requirements. This paper will give an overview of how the Software Processes have evolved, highlighting the positives as well as the negatives. In addition, we will mention the COTS tools that have been integrated into the processes and how the COTS have provided value to the project.

24 CFR 2002.7 - OIG processing of requests.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false OIG processing of requests. 2002.7 Section 2002.7 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF INSPECTOR GENERAL, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT AVAILABILITY OF...

CORPEX{reg_sign} NORM decontamination process

DOE Office of Scientific and Technical Information (OSTI.GOV)

Azrak, R.G.

1997-02-01

This paper describes a commecial process which has been developed for application to the remediation of NORM deposits on metal parts or embedded in scales on such parts. The process employs a registered chemical process, involving non-RCRA regulated chemicals, which can remove fixed {sup 226,228}Radium, {sup 210}Lead, and {sup 210}Polonium. The author describes the capabilities of the chemical process which has been developed, the way it is offered to potential customers as a practical process, and numerous examples of its application in the field.

Low cost solar array project. Experimental process system development unit for producing semiconductor-grade silicon using the silane-to-silicon process

NASA Technical Reports Server (NTRS)

1980-01-01

Technical activities are reported in the design of process, facilities, and equipment for producing silicon at a rate and price comensurate with production goals for low cost solar cell modules. The silane-silicone process has potential for providing high purity poly-silicon on a commercial scale at a price of fourteen dollars per kilogram by 1986, (1980 dollars). Commercial process, economic analysis, process support research and development, and quality control are discussed.

Development of integrated control system for smart factory in the injection molding process

NASA Astrophysics Data System (ADS)

Chung, M. J.; Kim, C. Y.

2018-03-01

In this study, we proposed integrated control system for automation of injection molding process required for construction of smart factory. The injection molding process consists of heating, tool close, injection, cooling, tool open, and take-out. Take-out robot controller, image processing module, and process data acquisition interface module are developed and assembled to integrated control system. By adoption of integrated control system, the injection molding process can be simplified and the cost for construction of smart factory can be inexpensive.

Development and Validation of a Shear Punch Test Fixture

DTIC Science & Technology

2013-08-01

composites (MMC) manufactured by friction stir processing (FSP) that are being developed as part of a Technology Investment Fund (TIF) project, as the...leading a team of government departments and academics to develop a friction stir processing (FSP) based procedure to create metal matrix composite... friction stir process to fabricate surface metal matrix composites in aluminum alloys for potential application in light armoured vehicles. The

Measuring the software process and product: Lessons learned in the SEL

NASA Technical Reports Server (NTRS)

Basili, V. R.

1985-01-01

The software development process and product can and should be measured. The software measurement process at the Software Engineering Laboratory (SEL) has taught a major lesson: develop a goal-driven paradigm (also characterized as a goal/question/metric paradigm) for data collection. Project analysis under this paradigm leads to a design for evaluating and improving the methodology of software development and maintenance.

Clinical ethics protocols in the clinical ethics committees of Madrid.

PubMed

Herreros, Benjamin; Ramnath, Venktesh R; Bishop, Laura; Pintor, Emilio; Martín, María Dolores; Sánchez-González, Miguel A

2014-03-01

Currently, The nature and scope of Clinical Ethics Protocols (CEPs) in Madrid (Spain) are not well understood. The main objective is to describe the features of 'guideline/recommendation' type CEPs that have been or are being developed by existing Clinical Ethics Committees (CECs) in Madrid. Secondary objectives include characterisation of those CECs that have been the most prolific in reference to CEP creation and implementation and identification of any trends in future CEP development. We collected CEPs produced and in process by CECs accredited in the public hospitals in Madrid, Spain, from 1996 to 2008. CECs developed 30 CEPs, with 10 more in process. The most common topic is refusal of treatment (seven CEPs developed; two in process). If CEPs addressing terminal illness, Do-Not-Resuscitate orders and advance directives are placed into a separate 'ethical problems at the end of life' category, this CEP subject emerges as the most common (eight developed; four in process). There is a relationship between the age of the CEC and the development of CEPs (the oldest CECs have developed more CEPs). CECs now seem to be more likely to engage in CEP development. The CECs in Madrid, Spain, have developed a significant number of CEPs (30 in total and 10 in process) and there is a trend towards continued development. The most frequent topics are ethical problems at the end of life and refusal of treatment by the patient.

The Modular Modeling System (MMS): User's Manual

USGS Publications Warehouse

Leavesley, G.H.; Restrepo, Pedro J.; Markstrom, S.L.; Dixon, M.; Stannard, L.G.

1996-01-01

The Modular Modeling System (MMS) is an integrated system of computer software that has been developed to provide the research and operational framework needed to support development, testing, and evaluation of physical-process algorithms and to facilitate integration of user-selected sets of algorithms into operational physical-process models. MMS uses a module library that contains modules for simulating a variety of water, energy, and biogeochemical processes. A model is created by selectively coupling the most appropriate modules from the library to create a 'suitable' model for the desired application. Where existing modules do not provide appropriate process algorithms, new modules can be developed. The MMS user's manual provides installation instructions and a detailed discussion of system concepts, module development, and model development and application using the MMS graphical user interface.

Consolidated fuel reprocessing program

NASA Astrophysics Data System (ADS)

1985-02-01

Improved processes and components for the Breeder Reprocessing Engineering Test (BRET) were identified and developed as well as the design, procurement and development of prototypic equipment. The integrated testing of process equipment and flowsheets prototypical of a pilot scale full reprocessing plant, and also for testing prototypical remote features of specific complex components in the system are provided. Information to guide the long range activities of the Consolidated Fuel Reprocessing Program (CERP), a focal point for foreign exchange activities, and support in specialized technical areas are described. Research and development activities in HTGR fuel treatment technology are being conducted. Head-end process and laboratory scale development efforts, as well as studies specific to HTGR fuel, are reported. The development of off-gas treatment processes has generic application to fuel reprocessing, progress in this work is also reported.

The jABC Approach to Rigorous Collaborative Development of SCM Applications

NASA Astrophysics Data System (ADS)

Hörmann, Martina; Margaria, Tiziana; Mender, Thomas; Nagel, Ralf; Steffen, Bernhard; Trinh, Hong

Our approach to the model-driven collaborative design of IKEA's P3 Delivery Management Process uses the jABC [9] for model driven mediation and choreography to complement a RUP-based (Rational Unified Process) development process. jABC is a framework for service development based on Lightweight Process Coordination. Users (product developers and system/software designers) easily develop services and applications by composing reusable building-blocks into (flow-) graph structures that can be animated, analyzed, simulated, verified, executed, and compiled. This way of handling the collaborative design of complex embedded systems has proven to be effective and adequate for the cooperation of non-programmers and non-technical people, which is the focus of this contribution, and it is now being rolled out in the operative practice.

Small Business Apparel Retailing in Jamaica: An Exploratory Investigation into Product Development Processes and Practices

ERIC Educational Resources Information Center

Johnson-Leslie, Natalie; Gaskill, LuAnn R.

2006-01-01

While the process and practices of retail product development in developed countries have been documented, a void exists in descriptive analysis regarding retail product development in an international setting. The primary purpose of this study was to explore small business apparel retailing, and specifically the retail product development process…

Developmental State Policy, Educational Development, and Economic Development: Policy Processes in South Korea (1961-1979)

ERIC Educational Resources Information Center

Kim, Ki Su

2012-01-01

This paper explores two inter-connected issues--the state's role in educational development and educational contribution to economic development--in the policy processes entailed by the South Korean state's pursuit of economic development during the Park Chung Hi era, 1961-1979. It disputes the statist view that South Korea's economic development…

Annotation: Development of facial expression recognition from childhood to adolescence: behavioural and neurological perspectives.

PubMed

Herba, Catherine; Phillips, Mary

2004-10-01

Intact emotion processing is critical for normal emotional development. Recent advances in neuroimaging have facilitated the examination of brain development, and have allowed for the exploration of the relationships between the development of emotion processing abilities, and that of associated neural systems. A literature review was performed of published studies examining the development of emotion expression recognition in normal children and psychiatric populations, and of the development of neural systems important for emotion processing. Few studies have explored the development of emotion expression recognition throughout childhood and adolescence. Behavioural studies suggest continued development throughout childhood and adolescence (reflected by accuracy scores and speed of processing), which varies according to the category of emotion displayed. Factors such as sex, socio-economic status, and verbal ability may also affect this development. Functional neuroimaging studies in adults highlight the role of the amygdala in emotion processing. Results of the few neuroimaging studies in children have focused on the role of the amygdala in the recognition of fearful expressions. Although results are inconsistent, they provide evidence throughout childhood and adolescence for the continued development of and sex differences in amygdalar function in response to fearful expressions. Studies exploring emotion expression recognition in psychiatric populations of children and adolescents suggest deficits that are specific to the type of disorder and to the emotion displayed. Results from behavioural and neuroimaging studies indicate continued development of emotion expression recognition and neural regions important for this process throughout childhood and adolescence. Methodological inconsistencies and disparate findings make any conclusion difficult, however. Further studies are required examining the relationship between the development of emotion expression recognition and that of underlying neural systems, in particular subcortical and prefrontal cortical structures. These will inform understanding of the neural bases of normal and abnormal emotional development, and aid the development of earlier interventions for children and adolescents with psychiatric disorders.

A Pipeline Tool for CCD Image Processing

NASA Astrophysics Data System (ADS)

Bell, Jon F.; Young, Peter J.; Roberts, William H.; Sebo, Kim M.

MSSSO is part of a collaboration developing a wide field imaging CCD mosaic (WFI). As part of this project, we have developed a GUI based pipeline tool that is an integrated part of MSSSO's CICADA data acquisition environment and processes CCD FITS images as they are acquired. The tool is also designed to run as a stand alone program to process previously acquired data. IRAF tasks are used as the central engine, including the new NOAO mscred package for processing multi-extension FITS files. The STScI OPUS pipeline environment may be used to manage data and process scheduling. The Motif GUI was developed using SUN Visual Workshop. C++ classes were written to facilitate launching of IRAF and OPUS tasks. While this first version implements calibration processing up to and including flat field corrections, there is scope to extend it to other processing.

Development of pulsed processes for the manufacture of solar cells

NASA Technical Reports Server (NTRS)

Minnucci, J. A.

1978-01-01

The results of a 1-year program to develop the processes required for low-energy ion implantation for the automated production of silicon solar cells are described. The program included: (1) demonstrating state-of-the-art ion implantation equipment and designing an automated ion implanter, (2) making efforts to improve the performance of ion-implanted solar cells to 16.5 percent AM1, (3) developing a model of the pulse annealing process used in solar cell production, and (4) preparing an economic analysis of the process costs of ion implantation.

Vehicle Modeling for use in the CAFE model: Process description and modeling assumptions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moawad, Ayman; Kim, Namdoo; Rousseau, Aymeric

2016-06-01

The objective of this project is to develop and demonstrate a process that, at a minimum, provides more robust information that can be used to calibrate inputs applicable under the CAFE model’s existing structure. The project will be more fully successful if a process can be developed that minimizes the need for decision trees and replaces the synergy factors by inputs provided directly from a vehicle simulation tool. The report provides a description of the process that was developed by Argonne National Laboratory and implemented in Autonomie.

Process Monitoring Evaluation and Implementation for the Wood Abrasive Machining Process

PubMed Central

Saloni, Daniel E.; Lemaster, Richard L.; Jackson, Steven D.

2010-01-01

Wood processing industries have continuously developed and improved technologies and processes to transform wood to obtain better final product quality and thus increase profits. Abrasive machining is one of the most important of these processes and therefore merits special attention and study. The objective of this work was to evaluate and demonstrate a process monitoring system for use in the abrasive machining of wood and wood based products. The system developed increases the life of the belt by detecting (using process monitoring sensors) and removing (by cleaning) the abrasive loading during the machining process. This study focused on abrasive belt machining processes and included substantial background work, which provided a solid base for understanding the behavior of the abrasive, and the different ways that the abrasive machining process can be monitored. In addition, the background research showed that abrasive belts can effectively be cleaned by the appropriate cleaning technique. The process monitoring system developed included acoustic emission sensors which tended to be sensitive to belt wear, as well as platen vibration, but not loading, and optical sensors which were sensitive to abrasive loading. PMID:22163477

Processes involved in the development of latent fingerprints using the cyanoacrylate fuming method.

PubMed

Lewis, L A; Smithwick, R W; Devault, G L; Bolinger, B; Lewis, S A

2001-03-01

Chemical processes involved in the development of latent fingerprints using the cyanoacrylate fuming method have been studied. Two major types of latent prints have been investigated-clean and oily prints. Scanning electron microscopy (SEM) has been used as a tool for determining the morphology of the polymer developed separately on clean and oily prints after cyanoacrylate fuming. A correlation between the chemical composition of an aged latent fingerprint, prior to development, and the quality of a developed fingerprint has been observed in the morphology. The moisture in the print prior to fuming has been found to be more important than the moisture in the air during fuming for the development of a useful latent print. In addition, the amount of time required to develop a high quality latent print has been found to be within 2 min. The cyanoacrylate polymerization process is extremely rapid. When heat is used to accelerate the fuming process, typically a period of 2 min is required to develop the print. The optimum development time depends upon the concentration of cyanoacrylate vapors within the enclosure.

Missile signal processing common computer architecture for rapid technology upgrade

NASA Astrophysics Data System (ADS)

Rabinkin, Daniel V.; Rutledge, Edward; Monticciolo, Paul

2004-10-01

Interceptor missiles process IR images to locate an intended target and guide the interceptor towards it. Signal processing requirements have increased as the sensor bandwidth increases and interceptors operate against more sophisticated targets. A typical interceptor signal processing chain is comprised of two parts. Front-end video processing operates on all pixels of the image and performs such operations as non-uniformity correction (NUC), image stabilization, frame integration and detection. Back-end target processing, which tracks and classifies targets detected in the image, performs such algorithms as Kalman tracking, spectral feature extraction and target discrimination. In the past, video processing was implemented using ASIC components or FPGAs because computation requirements exceeded the throughput of general-purpose processors. Target processing was performed using hybrid architectures that included ASICs, DSPs and general-purpose processors. The resulting systems tended to be function-specific, and required custom software development. They were developed using non-integrated toolsets and test equipment was developed along with the processor platform. The lifespan of a system utilizing the signal processing platform often spans decades, while the specialized nature of processor hardware and software makes it difficult and costly to upgrade. As a result, the signal processing systems often run on outdated technology, algorithms are difficult to update, and system effectiveness is impaired by the inability to rapidly respond to new threats. A new design approach is made possible three developments; Moore's Law - driven improvement in computational throughput; a newly introduced vector computing capability in general purpose processors; and a modern set of open interface software standards. Today's multiprocessor commercial-off-the-shelf (COTS) platforms have sufficient throughput to support interceptor signal processing requirements. This application may be programmed under existing real-time operating systems using parallel processing software libraries, resulting in highly portable code that can be rapidly migrated to new platforms as processor technology evolves. Use of standardized development tools and 3rd party software upgrades are enabled as well as rapid upgrade of processing components as improved algorithms are developed. The resulting weapon system will have a superior processing capability over a custom approach at the time of deployment as a result of a shorter development cycles and use of newer technology. The signal processing computer may be upgraded over the lifecycle of the weapon system, and can migrate between weapon system variants enabled by modification simplicity. This paper presents a reference design using the new approach that utilizes an Altivec PowerPC parallel COTS platform. It uses a VxWorks-based real-time operating system (RTOS), and application code developed using an efficient parallel vector library (PVL). A quantification of computing requirements and demonstration of interceptor algorithm operating on this real-time platform are provided.

REPORT ON TWO PROCESS EQUIPMENT CHANGES FOR FEDERAL PAINTING FACILITIES

EPA Science Inventory

EPA's National Risk Management Research Laboratory (NRMRL) has actively participated in the Strategic Environmental Research and Development Program (SERDP) to develop innovative technologies and processes for the reduction of environmental pollution. Technology developments fro...

Measuring the impact of computer resource quality on the software development process and product

NASA Technical Reports Server (NTRS)

Mcgarry, Frank; Valett, Jon; Hall, Dana

1985-01-01

The availability and quality of computer resources during the software development process was speculated to have measurable, significant impact on the efficiency of the development process and the quality of the resulting product. Environment components such as the types of tools, machine responsiveness, and quantity of direct access storage may play a major role in the effort to produce the product and in its subsequent quality as measured by factors such as reliability and ease of maintenance. During the past six years, the NASA Goddard Space Flight Center has conducted experiments with software projects in an attempt to better understand the impact of software development methodologies, environments, and general technologies on the software process and product. Data was extracted and examined from nearly 50 software development projects. All were related to support of satellite flight dynamics ground-based computations. The relationship between computer resources and the software development process and product as exemplified by the subject NASA data was examined. Based upon the results, a number of computer resource-related implications are provided.

The development of emotion perception in face and voice during infancy.

PubMed

Grossmann, Tobias

2010-01-01

Interacting with others by reading their emotional expressions is an essential social skill in humans. How this ability develops during infancy and what brain processes underpin infants' perception of emotion in different modalities are the questions dealt with in this paper. Literature review. The first part provides a systematic review of behavioral findings on infants' developing emotion-reading abilities. The second part presents a set of new electrophysiological studies that provide insights into the brain processes underlying infants' developing abilities. Throughout, evidence from unimodal (face or voice) and multimodal (face and voice) processing of emotion is considered. The implications of the reviewed findings for our understanding of developmental models of emotion processing are discussed. The reviewed infant data suggest that (a) early in development, emotion enhances the sensory processing of faces and voices, (b) infants' ability to allocate increased attentional resources to negative emotional information develops earlier in the vocal domain than in the facial domain, and (c) at least by the age of 7 months, infants reliably match and recognize emotional information across face and voice.

Chinese Scientific and Technical Information Institutions: Development and Perspective

ERIC Educational Resources Information Center

Yanning, Zheng

2011-01-01

The collection, storage, processing, and dissemination of scientific and technical information make an important basis for economic and social development as well as for scientific development. A nation has to develop the right mechanisms and modalities to collect, store, process, and disseminate scientific and technical information tailored to…

Organizational Development: Values, Process, and Technology.

ERIC Educational Resources Information Center

Margulies, Newton; Raia, Anthony P.

The current state-of-the-art of organizational development is the focus of this book. The five parts into which the book is divided are as follows: Part One--Introduction (Organizational Development in Perspective--the nature, values, process, and technology of organizational development); Part Two--The Components of Organizational Developments…

Guide Book for Curriculum Development and Adaptation. Draft.

ERIC Educational Resources Information Center

United Nations Educational, Scientific and Cultural Organization, Bangkok (Thailand). Principal Regional Office for Asia and the Pacific.

This guide was developed as a cooperative initiative by UNESCO member countries to provide information about the process of development and adaptation of a flexible, competency-based curriculum, especially in vocational education. The guidebook outlines an exemplar process of education organized in 11 stages of design and development based on…

Cognitive Processes and Theory Development: A Reply to Spencer and Karmiloff-Smith.

ERIC Educational Resources Information Center

Gellatly, Angus

1997-01-01

Focuses on the role of enculturation in children's cognitive development by distinguishing between, and elaborating upon, three factors: (1) cultural context; (2) cognitive contents; and (3) cognitive processes. Suggests problems inherent in positing homologies between children's cognitive development and the historical development of scientific…

Developing and Implementing a Process for the Review of Nonacademic Units.

ERIC Educational Resources Information Center

Brown, Marilyn K.

1989-01-01

A major research university's recently developed process for systematic evaluation of nonacademic units is described, and the steps in its development and implementation are outlined: review of literature on organizational effectiveness; survey of peer institutions; development of guidelines for review; and implementation in several campus units.…

Scriptotherapy: A Technique for Conflict Resolution.

ERIC Educational Resources Information Center

Johnson, Roy E.

Part 1 of this dissertation contains an introductory chapter entitled, "The Children Shout Fight Fight," in which the written analytical process named Scriptotherapy is discussed. In Chapter 1, "Early Adolescence an Ongoing Process," early adolescent growth and development, the process of moral development, temperament types…

Our Application of ISO 9000.

ERIC Educational Resources Information Center

Hammond, Jane

2000-01-01

Since a large, underfunded urban Colorado district initiated ISO 9000 reforms, administrators and staff have reviewed 14 central-office departments' processes to improve efficiency and enhance student outcomes. Jefferson County has saved $900,000 annually on purchasing processes, developed a quality curriculum-development process, and improved…

DEVELOPMENT OF CAPE-OPEN COMPLIANT PROCESS MODELING COMPONENTS IN MICROSOFT .NET

EPA Science Inventory

The CAPE-OPEN middleware standards were created to allow process modeling components (PMCs) developed by third parties to be used in any process modeling environment (PME) utilizing these standards. The CAPE-OPEN middleware specifications were based upon both Microsoft's Compone...

Tailoring advanced technologies for air traffic control : the importance of the development process

DOT National Transportation Integrated Search

1995-04-01

This paper describes a process that is currently being applied to the : development and assessment of an advanced air traffic control (ATC) system, the : Center TRACON Automation System (CTAS). This process deviates from established : practices of AT...

ISO 9000 and/or Systems Engineering Capability Maturity Model?

NASA Technical Reports Server (NTRS)

Gholston, Sampson E.

2002-01-01

For businesses and organizations to remain competitive today they must have processes and systems in place that will allow them to first identify customer needs and then develop products/processes that will meet or exceed the customers needs and expectations. Customer needs, once identified, are normally stated as requirements. Designers can then develop products/processes that will meet these requirements. Several functions, such as quality management and systems engineering management are used to assist product development teams in the development process. Both functions exist in all organizations and both have a similar objective, which is to ensure that developed processes will meet customer requirements. Are efforts in these organizations being duplicated? Are both functions needed by organizations? What are the similarities and differences between the functions listed above? ISO 9000 is an international standard of goods and services. It sets broad requirements for the assurance of quality and for management's involvement. It requires organizations to document the processes and to follow these documented processes. ISO 9000 gives customers assurance that the suppliers have control of the process for product development. Systems engineering can broadly be defined as a discipline that seeks to ensure that all requirements for a system are satisfied throughout the life of the system by preserving their interrelationship. The key activities of systems engineering include requirements analysis, functional analysis/allocation, design synthesis and verification, and system analysis and control. The systems engineering process, when followed properly, will lead to higher quality products, lower cost products, and shorter development cycles. The System Engineering Capability Maturity Model (SE-CMM) will allow companies to measure their system engineering capability and continuously improve those capabilities. ISO 9000 and SE-CMM seem to have a similar objective, which is to document the organization's processes and certify to potential customers the capability of a supplier to control the processes that determine the quality of the product or services being produced. The remaining sections of this report examine the differences and similarities between ISO 9000 and SE-CMM and make recommendations for implementation.

Assessment Methodology for Process Validation Lifecycle Stage 3A.

PubMed

Sayeed-Desta, Naheed; Pazhayattil, Ajay Babu; Collins, Jordan; Chen, Shu; Ingram, Marzena; Spes, Jana

2017-07-01

The paper introduces evaluation methodologies and associated statistical approaches for process validation lifecycle Stage 3A. The assessment tools proposed can be applied to newly developed and launched small molecule as well as bio-pharma products, where substantial process and product knowledge has been gathered. The following elements may be included in Stage 3A: number of 3A batch determination; evaluation of critical material attributes, critical process parameters, critical quality attributes; in vivo in vitro correlation; estimation of inherent process variability (IPV) and PaCS index; process capability and quality dashboard (PCQd); and enhanced control strategy. US FDA guidance on Process Validation: General Principles and Practices, January 2011 encourages applying previous credible experience with suitably similar products and processes. A complete Stage 3A evaluation is a valuable resource for product development and future risk mitigation of similar products and processes. Elements of 3A assessment were developed to address industry and regulatory guidance requirements. The conclusions made provide sufficient information to make a scientific and risk-based decision on product robustness.

Development of Solvent Extraction Approach to Recycle Enriched Molybdenum Material

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tkac, Peter; Brown, M. Alex; Sen, Sujat

2016-06-01

Argonne National Laboratory, in cooperation with Oak Ridge National Laboratory and NorthStar Medical Technologies, LLC, is developing a recycling process for a solution containing valuable Mo-100 or Mo-98 enriched material. Previously, Argonne had developed a recycle process using a precipitation technique. However, this process is labor intensive and can lead to production of large volumes of highly corrosive waste. This report discusses an alternative process to recover enriched Mo in the form of ammonium heptamolybdate by using solvent extraction. Small-scale experiments determined the optimal conditions for effective extraction of high Mo concentrations. Methods were developed for removal of ammonium chloridemore » from the molybdenum product of the solvent extraction process. In large-scale experiments, very good purification from potassium and other elements was observed with very high recovery yields (~98%).« less

The GA sulfur-iodine water-splitting process - A status report

NASA Astrophysics Data System (ADS)

Besenbruch, G. E.; Chiger, H. D.; McCorkle, K. H.; Norman, J. H.; Rode, J. S.; Schuster, J. R.; Trester, P. W.

The development of a sulfur-iodine thermal water splitting cycle is described. The process features a 50% thermal efficiency, plus all liquid and gas handling. Basic chemical investigations comprised the development of multitemperature and multistage sulfuric acid boost reactors, defining the phase behavior of the HI/I2/H2O/H3PO4 mixtures, and development of a decomposition process for hydrogen iodide in the liquid phase. Initial process engineering studies have led to a 47% efficiency, improvements of 2% projected, followed by coupling high-temperature solar concentrators to the splitting processes to reduce power requirements. Conceptual flowsheets developed from bench models are provided; materials investigations have concentrated on candidates which can withstand corrosive mixtures at temperatures up to 400 deg K, with Hastelloy C-276 exhibiting the best properties for containment and heat exchange to I2.

Friction Stir Welding Development at NASA-Marshall Space Flight Center

NASA Technical Reports Server (NTRS)

Bhat, Biliyar N.; Carter, Robert W.; Ding, Robert J.; Lawless, Kirby G.; Nunes, Arthur C., Jr.; Russell, Carolyn K.; Shah, Sandeep R.

2001-01-01

This paper presents an overview of friction stir welding (FSW) process development and applications at Marshall Space Flight Center (MSFC). FSW process development started as a laboratory curiosity but soon found support from many users. The FSW process advanced very quickly and has found many applications both within and outside the aerospace industry. It is currently being adapted for joining key elements of the Space Shuttle External Tank for improved producibility and reliability. FSW process modeling is done to better understand and improve the process. Special tools have been developed to weld variable thickness materials including thin and thick materials. FSW is now being applied to higher temperature materials such as copper and to advanced materials such as metal matrix composites. FSW technology is being successfully transferred from MSFC laboratory to shop floors of many commercial companies.

The GA sulfur-iodine water-splitting process - A status report

NASA Technical Reports Server (NTRS)

Besenbruch, G. E.; Chiger, H. D.; Mccorkle, K. H.; Norman, J. H.; Rode, J. S.; Schuster, J. R.; Trester, P. W.

1981-01-01

The development of a sulfur-iodine thermal water splitting cycle is described. The process features a 50% thermal efficiency, plus all liquid and gas handling. Basic chemical investigations comprised the development of multitemperature and multistage sulfuric acid boost reactors, defining the phase behavior of the HI/I2/H2O/H3PO4 mixtures, and development of a decomposition process for hydrogen iodide in the liquid phase. Initial process engineering studies have led to a 47% efficiency, improvements of 2% projected, followed by coupling high-temperature solar concentrators to the splitting processes to reduce power requirements. Conceptual flowsheets developed from bench models are provided; materials investigations have concentrated on candidates which can withstand corrosive mixtures at temperatures up to 400 deg K, with Hastelloy C-276 exhibiting the best properties for containment and heat exchange to I2.

Promoting evidence informed policy making in Nigeria: a review of the maternal, newborn and child health policy development process

PubMed Central

Uneke, Chigozie Jesse; Sombie, Issiaka; Keita, Namoudou; Lokossou, Virgil; Johnson, Ermel; Ongolo-Zogo, Pierre; Uro-Chukwu, Henry Chukwuemeka

2017-01-01

Background: There is increasing recognition worldwide that health policymaking process should be informed by best available evidence. The purpose of this study was to review the policy documents on maternal, newborn and child health (MNCH) in Nigeria to assess the extent evidence informed policymaking mechanism was employed in the policy formulation process. Methods: A comprehensive literature search of websites of the Federal Ministry of Health(FMOH) Nigeria and other related ministries and agencies for relevant health policy documents related to MNCH from year 2000 to 2015 was undertaken. The following terms were used interchangeably for the literature search: maternal, child, newborn, health, policy, strategy,framework, guidelines, Nigeria. Results: Of the 108 policy documents found, 19 (17.6%) of them fulfilled the study inclusion criteria. The policy documents focused on the major aspects of maternal health improvements in Nigeria such as reproductive health, anti-malaria treatment, development of adolescent and young people health, mid wives service scheme, prevention of mother to child transmission of HIV and family planning. All the policy documents indicated that a consultative process of collection of input involving multiple stakeholders was employed, but there was no rigorous scientific process of assessing, adapting, synthesizing and application of scientific evidence reported in the policy development process. Conclusion: It is recommended that future health policy development process on MNCH should follow evidence informed policy making process and clearly document the process of incorporating evidence in the policy development. PMID:29085794

The development of a science process assessment for fourth-grade students

NASA Astrophysics Data System (ADS)

Smith, Kathleen A.; Welliver, Paul W.

In this study, a multiple-choice test entitled the Science Process Assessment was developed to measure the science process skills of students in grade four. Based on the Recommended Science Competency Continuum for Grades K to 6 for Pennsylvania Schools, this instrument measured the skills of (1) observing, (2) classifying, (3) inferring, (4) predicting, (5) measuring, (6) communicating, (7) using space/time relations, (8) defining operationally, (9) formulating hypotheses, (10) experimenting, (11) recognizing variables, (12) interpreting data, and (13) formulating models. To prepare the instrument, classroom teachers and science educators were invited to participate in two science education workshops designed to develop an item bank of test questions applicable to measuring process skill learning. Participants formed writing teams and generated 65 test items representing the 13 process skills. After a comprehensive group critique of each item, 61 items were identified for inclusion into the Science Process Assessment item bank. To establish content validity, the item bank was submitted to a select panel of science educators for the purpose of judging item acceptability. This analysis yielded 55 acceptable test items and produced the Science Process Assessment, Pilot 1. Pilot 1 was administered to 184 fourth-grade students. Students were given a copy of the test booklet; teachers read each test aloud to the students. Upon completion of this first administration, data from the item analysis yielded a reliability coefficient of 0.73. Subsequently, 40 test items were identified for the Science Process Assessment, Pilot 2. Using the test-retest method, the Science Process Assessment, Pilot 2 (Test 1 and Test 2) was administered to 113 fourth-grade students. Reliability coefficients of 0.80 and 0.82, respectively, were ascertained. The correlation between Test 1 and Test 2 was 0.77. The results of this study indicate that (1) the Science Process Assessment, Pilot 2, is a valid and reliable instrument applicable to measuring the science process skills of students in grade four, (2) using educational workshops as a means of developing item banks of test questions is viable and productive in the test development process, and (3) involving classroom teachers and science educators in the test development process is educationally efficient and effective.

How drugs are developed and approved by the FDA: current process and future directions.

PubMed

Ciociola, Arthur A; Cohen, Lawrence B; Kulkarni, Prasad

2014-05-01

This article provides an overview of FDA's regulatory processes for drug development and approval, and the estimated costs associated with the development of a drug, and also examines the issues and challenges facing the FDA in the near future. A literature search was performed using MEDLINE to summarize the current FDA drug approval processes and future directions. MEDLINE was further utilized to search for all cost analysis studies performed to evaluate the pharmaceutical industry R&D productivity and drug development cost estimates. While the drug approval process remains at high risk and spans over multiple years, the FDA drug review and approval process has improved, with the median approval time for new molecular drugs been reduced from 19 months to 10 months. The overall cost to development of a drug remains quite high and has been estimated to range from $868M to $1,241M USD. Several new laws have been enacted, including the FDA Safety and Innovation Act (FDASIA) of 2013, which is designed to improve the drug approval process and enhance access to new medicines. The FDA's improved processes for drug approval and post-market surveillance have achieved the goal of providing patients with timely access to effective drugs while minimizing the risk of drug-related harm. The FDA drug approval process is not without controversy, as a number of well-known gastroenterology drugs have been withdrawn from the US market over the past few years. With the approval of the new FDASIA law, the FDA will continue to improve their processes and, working together with the ACG through the FDA-Related Matters Committee, continue to develop safe and effective drugs for our patients.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simpson, L.

ITN Energy Systems, Inc., and Global Solar Energy, Inc., with the assistance of NREL's PV Manufacturing R&D program, have continued the advancement of CIGS production technology through the development of trajectory-oriented predictive/control models, fault-tolerance control, control-platform development, in-situ sensors, and process improvements. Modeling activities to date include the development of physics-based and empirical models for CIGS and sputter-deposition processing, implementation of model-based control, and application of predictive models to the construction of new evaporation sources and for control. Model-based control is enabled through implementation of reduced or empirical models into a control platform. Reliability improvement activities include implementation of preventivemore » maintenance schedules; detection of failed sensors/equipment and reconfiguration to continue processing; and systematic development of fault prevention and reconfiguration strategies for the full range of CIGS PV production deposition processes. In-situ sensor development activities have resulted in improved control and indicated the potential for enhanced process status monitoring and control of the deposition processes. Substantial process improvements have been made, including significant improvement in CIGS uniformity, thickness control, efficiency, yield, and throughput. In large measure, these gains have been driven by process optimization, which, in turn, have been enabled by control and reliability improvements due to this PV Manufacturing R&D program. This has resulted in substantial improvements of flexible CIGS PV module performance and efficiency.« less

Expertise Development With Different Types of Automation: A Function of Different Cognitive Abilities.

PubMed

Jipp, Meike

2016-02-01

I explored whether different cognitive abilities (information-processing ability, working-memory capacity) are needed for expertise development when different types of automation (information vs. decision automation) are employed. It is well documented that expertise development and the employment of automation lead to improved performance. Here, it is argued that a learner's ability to reason about an activity may be hindered by the employment of information automation. Additional feedback needs to be processed, thus increasing the load on working memory and decelerating expertise development. By contrast, the employment of decision automation may stimulate reasoning, increase the initial load on information-processing ability, and accelerate expertise development. Authors of past research have not investigated the interrelations between automation assistance, individual differences, and expertise development. Sixty-one naive learners controlled simulated air traffic with two types of automation: information automation and decision automation. Their performance was captured across 16 trials. Well-established tests were used to assess information-processing ability and working-memory capacity. As expected, learners' performance benefited from expertise development and decision automation. Furthermore, individual differences moderated the effect of the type of automation on expertise development: The employment of only information automation increased the load on working memory during later expertise development. The employment of decision automation initially increased the need to process information. These findings highlight the importance of considering individual differences and expertise development when investigating human-automation interaction. The results are relevant for selecting automation configurations for expertise development. © 2015, Human Factors and Ergonomics Society.

A resource for assessing information processing in the developing brain using EEG and eye tracking

PubMed Central

Langer, Nicolas; Ho, Erica J.; Alexander, Lindsay M.; Xu, Helen Y.; Jozanovic, Renee K.; Henin, Simon; Petroni, Agustin; Cohen, Samantha; Marcelle, Enitan T.; Parra, Lucas C.; Milham, Michael P.; Kelly, Simon P.

2017-01-01

We present a dataset combining electrophysiology and eye tracking intended as a resource for the investigation of information processing in the developing brain. The dataset includes high-density task-based and task-free EEG, eye tracking, and cognitive and behavioral data collected from 126 individuals (ages: 6–44). The task battery spans both the simple/complex and passive/active dimensions to cover a range of approaches prevalent in modern cognitive neuroscience. The active task paradigms facilitate principled deconstruction of core components of task performance in the developing brain, whereas the passive paradigms permit the examination of intrinsic functional network activity during varying amounts of external stimulation. Alongside these neurophysiological data, we include an abbreviated cognitive test battery and questionnaire-based measures of psychiatric functioning. We hope that this dataset will lead to the development of novel assays of neural processes fundamental to information processing, which can be used to index healthy brain development as well as detect pathologic processes. PMID:28398357

A Systematic Process for Developing High Quality SaaS Cloud Services

NASA Astrophysics Data System (ADS)

La, Hyun Jung; Kim, Soo Dong

Software-as-a-Service (SaaS) is a type of cloud service which provides software functionality through Internet. Its benefits are well received in academia and industry. To fully utilize the benefits, there should be effective methodologies to support the development of SaaS services which provide high reusability and applicability. Conventional approaches such as object-oriented methods do not effectively support SaaS-specific engineering activities such as modeling common features, variability, and designing quality services. In this paper, we present a systematic process for developing high quality SaaS and highlight the essentiality of commonality and variability (C&V) modeling to maximize the reusability. We first define criteria for designing the process model and provide a theoretical foundation for SaaS; its meta-model and C&V model. We clarify the notion of commonality and variability in SaaS, and propose a SaaS development process which is accompanied with engineering instructions. Using the proposed process, SaaS services with high quality can be effectively developed.

A resource for assessing information processing in the developing brain using EEG and eye tracking.

PubMed

Langer, Nicolas; Ho, Erica J; Alexander, Lindsay M; Xu, Helen Y; Jozanovic, Renee K; Henin, Simon; Petroni, Agustin; Cohen, Samantha; Marcelle, Enitan T; Parra, Lucas C; Milham, Michael P; Kelly, Simon P

2017-04-11

We present a dataset combining electrophysiology and eye tracking intended as a resource for the investigation of information processing in the developing brain. The dataset includes high-density task-based and task-free EEG, eye tracking, and cognitive and behavioral data collected from 126 individuals (ages: 6-44). The task battery spans both the simple/complex and passive/active dimensions to cover a range of approaches prevalent in modern cognitive neuroscience. The active task paradigms facilitate principled deconstruction of core components of task performance in the developing brain, whereas the passive paradigms permit the examination of intrinsic functional network activity during varying amounts of external stimulation. Alongside these neurophysiological data, we include an abbreviated cognitive test battery and questionnaire-based measures of psychiatric functioning. We hope that this dataset will lead to the development of novel assays of neural processes fundamental to information processing, which can be used to index healthy brain development as well as detect pathologic processes.

Making the PACS workstation a browser of image processing software: a feasibility study using inter-process communication techniques.

PubMed

Wang, Chunliang; Ritter, Felix; Smedby, Orjan

2010-07-01

To enhance the functional expandability of a picture archiving and communication systems (PACS) workstation and to facilitate the integration of third-part image-processing modules, we propose a browser-server style method. In the proposed solution, the PACS workstation shows the front-end user interface defined in an XML file while the image processing software is running in the background as a server. Inter-process communication (IPC) techniques allow an efficient exchange of image data, parameters, and user input between the PACS workstation and stand-alone image-processing software. Using a predefined communication protocol, the PACS workstation developer or image processing software developer does not need detailed information about the other system, but will still be able to achieve seamless integration between the two systems and the IPC procedure is totally transparent to the final user. A browser-server style solution was built between OsiriX (PACS workstation software) and MeVisLab (Image-Processing Software). Ten example image-processing modules were easily added to OsiriX by converting existing MeVisLab image processing networks. Image data transfer using shared memory added <10ms of processing time while the other IPC methods cost 1-5 s in our experiments. The browser-server style communication based on IPC techniques is an appealing method that allows PACS workstation developers and image processing software developers to cooperate while focusing on different interests.

Thermal Stir Welding Development at Marshall Space Flight Center

NASA Technical Reports Server (NTRS)

Ding, Robert J.

2008-01-01

Solid state welding processes have become the focus of welding process development at NASA's Marshall Space Flight Center. Unlike fusion weld processes such as tungsten inert gas (TIG), variable polarity plasma arc (VPPA), electron beam (EB), etc., solid state welding processes do not melt the material during welding. The resultant microstructure can be characterized as a dynamically recrystallized morphology much different than the casted, dentritic structure typical of fusion weld processes. The primary benefits of solid state processes over fusion weld processes include superior mechanic properties and the elimination of thermal distortion and residual stresses. These solid state processes attributes have profoundly influenced the direction of advanced welding research and development within the NASA agency. Thermal Stir Welding (TSW) is a new solid state welding process being developed at the Marshall Space Flight Center. Unlike friction stir welding, the heating, stirring and forging elements of the weld process can be decoupled for independent control. An induction coil induces energy into a workpiece to attain a desired plastic temperature. An independently controlled stir rod, captured within non-rotating containment plates, then stirs the plasticized material followed by forging plates/rollers that work the stirred weld joint. The independent control (decoupling) of heating, stirring and forging allows, theoretically, for the precision control of microstructure morphology. The TSW process is being used to evaluate the solid state joining of Haynes 230 for ARES J-2X applications. It is also being developed for 500-in (12.5 mm) thick commercially pure grade 2 titanium for navy applications. Other interests include Inconel 718 and stainless steel. This presentation will provide metallurgical and mechanical property data for these high melting temperature alloys.

Processability Theory and the Role of Morphology in English as a Second Language Development: A Longitudinal Study

ERIC Educational Resources Information Center

Dyson, Bronwen

2009-01-01

This article tests a prediction made by Processability Theory (Pienemann, 1998; 2005) that morphological acquisition is the driving force in English as a second language (ESL) development. It first outlines the model of psycholinguistic processing assumed by Processability Theory and shows how stages fall out from it. It then presents the…

Active vs. Passive Television Viewing: A Model of the Development of Television Information Processing by Children.

ERIC Educational Resources Information Center

Wright, John C.; And Others

A conceptual model of how children process televised information was developed with the goal of identifying those parameters of the process that are both measurable and manipulable in research settings. The model presented accommodates the nature of information processing both by the child and by the presentation by the medium. Presentation is…

HYPER-­TVT: Development and Implementation of an Interactive Learning Environment for Students of Chemical and Process Engineering

ERIC Educational Resources Information Center

Santoro, Marina; Mazzotti, Marco

2006-01-01

Hyper-TVT is a computer-aided education system that has been developed at the Institute of Process Engineering at the ETH Zurich. The aim was to create an interactive learning environment for chemical and process engineering students. The topics covered are the most important multistage separation processes, i.e. fundamentals of separation…

An interfaces approach to TES ground data system processing design with the Science Investigator-led Processing System (SIPS)

NASA Technical Reports Server (NTRS)

Kurian, R.; Grifin, A.

2002-01-01

Developing production-quality software to process the large volumes of scientific data is the responsibility of the TES Ground Data System, which is being developed at the Jet Propulsion Laboratory together with support contractor Raytheon/ITSS. The large data volume and processing requirements of the TES pose significant challenges to the design.

WISE: Automated support for software project management and measurement. M.S. Thesis

NASA Technical Reports Server (NTRS)

Ramakrishnan, Sudhakar

1995-01-01

One important aspect of software development and IV&V is measurement. Unless a software development effort is measured in some way, it is difficult to judge the effectiveness of current efforts and predict future performances. Collection of metrics and adherence to a process are difficult tasks in a software project. Change activity is a powerful indicator of project status. Automated systems that can handle change requests, issues, and other process documents provide an excellent platform for tracking the status of the project. A World Wide Web based architecture is developed for (a) making metrics collection an implicit part of the software process, (b) providing metric analysis dynamically, (c) supporting automated tools that can complement current practices of in-process improvement, and (d) overcoming geographical barrier. An operational system (WISE) instantiates this architecture allowing for the improvement of software process in a realistic environment. The tool tracks issues in software development process, provides informal communication between the users with different roles, supports to-do lists (TDL), and helps in software process improvement. WISE minimizes the time devoted to metrics collection, analysis, and captures software change data. Automated tools like WISE focus on understanding and managing the software process. The goal is improvement through measurement.

Isolation and Purification of Biotechnological Products

NASA Astrophysics Data System (ADS)

Hubbuch, Jürgen; Kula, Maria-Regina

2007-05-01

The production of modern pharma proteins is one of the most rapid growing fields in biotechnology. The overall development and production is a complex task ranging from strain development and cultivation to the purification and formulation of the drug. Downstream processing, however, still accounts for the major part of production costs. This is mainly due to the high demands on purity and thus safety of the final product and results in processes with a sequence of typically more than 10 unit operations. Consequently, even if each process step would operate at near optimal yield, a very significant amount of product would be lost. The majority of unit operations applied in downstream processing have a long history in the field of chemical and process engineering; nevertheless, mathematical descriptions of the respective processes and the economical large-scale production of modern pharmaceutical products are hampered by the complexity of the biological feedstock, especially the high molecular weight and limited stability of proteins. In order to develop new operational steps as well as a successful overall process, it is thus a necessary prerequisite to develop a deeper understanding of the thermodynamics and physics behind the applied processes as well as the implications for the product.

Review of operations in the Virginia Department of Transportation's project development process.

DOT National Transportation Integrated Search

2007-01-01

The Virginia Department of Transportation's (VDOT's) project development process (PDP) directs how construction projects are developed. The purpose of this study was to evaluate the manner in which operations is currently considered throughout the PD...

77 FR 66638 - The Standard on Process Safety Management of Highly Hazardous Chemicals; Extension of the Office...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-06

... analyses and the development of other elements of the standard; developing a written action plan for..., revalidating and retaining the process hazard analysis; developing and implementing written operating [[Page 66639

High flow rate development: process optimization using megasonic immersion development (MID)

NASA Astrophysics Data System (ADS)

Courboin, Daniel; Choi, Jong Woo; Jung, Sang Hyun; Baek, Seung Hee; Kim, Lee Ju

2004-12-01

In previous study the high impact of development by-products on Critical Dimension (CD) through the microloading effect has been demonstrated for a Novolak resist. In this paper, through further tests involving Chemically Amplified Resist (CAR) and Novolak resist, the microloading effect of development is characterized and tentative mechanism is presented. Megasonic Immersion Development (MID), a high flow rate development technique similar to the Proximity Gap Suction Development (PGSD), was used and compared with spin spray development and puddle development. On TOK IP3600, a Novolak resist, we have explored a wide range of process conditions with MID. Developer temperature was varied from 5°C to 40°C with TMAH developer concentration of 1.9% and 2.38% resulting in an isofocal dose range of 90mJ to 190mJ. Exposure Focus Matrix (EFM) with a specific microloading pattern and resist cross sections were performed. The best conditions are quite far from the standard process advised by the resist supplier. Very nice standing wave profile was obtained at high temperature development. On CAR, JEOL 9000MVII, a 50kV e-beam vector scan tool, and ETEC ALTA 4300, a DUV raster scan tool, were used with different develop process techniques including MID. FujiFilm Arch FEP-171 positive CAR and Sumitomo NEB-22 negative CAR were used on 50kV writing tool. Sumitomo PEK-130 was used on DUV writing tool. FEP-171 and PEK-1300 show microloading effect on high density patterns but not NEB-22. MID shows also improved reproduction of develop features in the chrome and a 20% improvement of CD uniformity. The results of this study seem to indicate that a closer look in their development process is needed for 90nm and 65nm technologies.

Development of NASA's Sample Cartridge Assembly: Summary of GEDS Design, Development Testing, and Thermal Analyses

NASA Technical Reports Server (NTRS)

O'Connor, Brian; Hernandez, Deborah; Hornsby, Linda; Brown, Maria; Horton-Mullins, Kathryn

2017-01-01

Outline: Background of ISS (International Space Station) Material Science Research Rack; NASA SCA (Sample Cartridge Assembly) Design; GEDS (Gravitational Effects in Distortion in Sintering) Experiment Ampoule Design; Development Testing Summary; Thermal Modeling and Analysis. Summary: GEDS design development challenging (GEDS Ampoule design developed through MUGS (Microgravity) testing; Short duration transient sample processing; Unable to measure sample temperatures); MUGS Development testing used to gather data (Actual LGF (Low Gradient Furnace)-like furnace response; Provided sample for sintering evaluation); Transient thermal model integral to successful GEDS experiment (Development testing provided furnace response; PI (Performance Indicator) evaluation of sintering anchored model evaluation of processing durations; Thermal transient model used to determine flight SCA sample processing profiles).

Development and Use of a Goal Setting/Attainment Process Designed To Measure a Teacher's Ability To Engage in Professional Growth and Leadership Initiatives.

ERIC Educational Resources Information Center

Minix, Nancy; And Others

The process used to evaluate progress in identifying the goals to be used in evaluating teacher performance under the Kentucky Career Ladder Program is described. The process pertains to two areas of teacher development: (1) professional growth and development, and (2) professional leadership and initiative. A total of 1,650 individuals were asked…

Analysis and Development of a Web-Enabled Planning and Scheduling Database Application

DTIC Science & Technology

2013-09-01

establishes an entity—relationship diagram for the desired process, constructs an operable database using MySQL , and provides a web- enabled interface for...development, develop, design, process, re- engineering, reengineering, MySQL , structured query language, SQL, myPHPadmin. 15. NUMBER OF PAGES 107 16...relationship diagram for the desired process, constructs an operable database using MySQL , and provides a web-enabled interface for the population of

NASA Procurement Career Development Program

NASA Technical Reports Server (NTRS)

1987-01-01

The NASA Procurement Career Development Program establishes an agency-wide framework for the management of career development activity in the procurement field. Within this framework, installations are encouraged to modify the various components to meet installation-specific mission and organization requirements. This program provides a systematic process for the assessment of and planning for the development, training, and education required to increase the employees' competence in the procurement work functions. It includes the agency-wide basic knowledge and skills by career field and level upon which individual and organizational development plans are developed. Also, it provides a system that is compatible with other human resource management and development systems, processes, and activities. The compatibility and linkage are important in fostering the dual responsibility of the individual and the organization in the career development process.

Assessment of MSFCs Process for the Development and Activation of Space Act Agreements

NASA Technical Reports Server (NTRS)

Daugherty, Rachel A.

2014-01-01

A Space Act Agreement (SAA) is a contractual vehicle that NASA utilizes to form partnerships with non-NASA entities to stimulate cutting-edge innovation within the science and technology communities while concurrently supporting the NASA missions. SAAs are similar to traditional contracts in that they involve the commitment of Agency resources but allow more flexibility and are more cost effective to implement than traditional contracts. Consequently, the use of SAAs to develop partnerships has greatly increased over the past several years. To facilitate this influx of SAAs, Marshall Space Flight Center (MSFC) developed a process during a kaizen event to streamline and improve the quality of SAAs developed at the Center level. This study assessed the current SAA process to determine if improvements could be implemented to increase productivity, decrease time to activation, and improve the quality of deliverables. Using a combination of direct procedural observation, personnel interviews, and statistical analysis, elements of the process in need of remediation were identified and potential solutions developed. The findings focus primarily on the difficulties surrounding tracking and enforcing process adherence and communication issues among stakeholders. Potential solutions include utilizing customer relationship management (CRM) software to facilitate process coordination and co-locating or potentially merging the two separate organizations involved in SAA development and activation at MSFC.

Concise Review: Process Development Considerations for Cell Therapy

PubMed Central

Brieva, Thomas; Raviv, Lior; Rowley, Jon; Niss, Knut; Brandwein, Harvey; Oh, Steve; Karnieli, Ohad

2015-01-01

The development of robust and well-characterized methods of production of cell therapies has become increasingly important as therapies advance through clinical trials toward approval. A successful cell therapy will be a consistent, safe, and effective cell product, regardless of the cell type or application. Process development strategies can be developed to gain efficiency while maintaining or improving safety and quality profiles. This review presents an introduction to the process development challenges of cell therapies and describes some of the tools available to address production issues. This article will provide a summary of what should be considered to efficiently advance a cellular therapy from the research stage through clinical trials and finally toward commercialization. The identification of the basic questions that affect process development is summarized in the target product profile, and considerations for process optimization are discussed. The goal is to identify potential manufacturing concerns early in the process so they may be addressed effectively and thus increase the probability that a therapy will be successful. Significance The present study contributes to the field of cell therapy by providing a resource for those transitioning a potential therapy from the research stage to clinical and commercial applications. It provides the necessary steps that, when followed, can result in successful therapies from both a clinical and commercial perspective. PMID:26315572

[Development of guidance for the approval process of brand-new medical products and regenerative medicine products].

PubMed

Niimi, Shingo

2015-01-01

Ministry of Health, Labour and Weltare has been conducting development of guidance for the approval process of brand-new medical products/development of guidance for medical devices in collaboration with Ministry of Economy, Trade and Industry as part of measures to promote practical use of brand-new medical products since 2005. The objective of this project is to expedite the processes from developmental process of medical devices to approval review and to introduce the medical devices to medical front quickly.. Ministry of Health, Labour and Welfare side has been making guidance for the guide in approval process of brand-new medical products and regeneration medicine products to aim at acceleration and facilitation of development and approval process of innovative medical products. Twenty-two of the guidance have been issued as director of the evaluation and licensing division. The evaluation index about safety and efficacy required for medical devices and regenerative medicine products in progress were put together in these guidance and useful for medical devices developer to understand the point at the approved review. Therefore, I think that the evaluation index could also contribute to the efficient product development. The guidance about implantable artificial heart is issued as the representative example which was useful in the approved review.

EXTRAPOLATION FROM IN VITRO MECHANISMS TO IN VIVO EFFECTS FOR DEVELOPMENTAL NEUROTOXICOLOGY.

EPA Science Inventory

Processes that are critical to development of the nervous system can be altered by both genetic and epigenetic factors. Developmental exposure to neurotoxicants can alter these processes and lead to perturbation of normal neural development. As numerous processes occur in tande...

Using Automatic Code Generation in the Attitude Control Flight Software Engineering Process

NASA Technical Reports Server (NTRS)

McComas, David; O'Donnell, James R., Jr.; Andrews, Stephen F.

1999-01-01

This paper presents an overview of the attitude control subsystem flight software development process, identifies how the process has changed due to automatic code generation, analyzes each software development phase in detail, and concludes with a summary of our lessons learned.

The Automation of Reserve Processing.

ERIC Educational Resources Information Center

Self, James

1985-01-01

Describes an automated reserve processing system developed locally at Clemons Library, University of Virginia. Discussion covers developments in the reserve operation at Clemons Library, automation of the processing and circulation functions of reserve collections, and changes in reserve operation performance and staffing needs due to automation.…

Soil Genesis and Development, Lesson 2 - Processes of Weathering

USDA-ARS?s Scientific Manuscript database

Weathering processes — which include physical, chemical, and biological — contribute to the development of soil. The learning objectives of the lesson are: 1) Define and distinguish physical, chemical, and biological weathering processes; and 2) Describe how rock and mineral properties and environm...

Flight Dynamics Mission Support and Quality Assurance Process

NASA Technical Reports Server (NTRS)

Oh, InHwan

1996-01-01

This paper summarizes the method of the Computer Sciences Corporation Flight Dynamics Operation (FDO) quality assurance approach to support the National Aeronautics and Space Administration Goddard Space Flight Center Flight Dynamics Support Branch. Historically, a strong need has existed for developing systematic quality assurance using methods that account for the unique nature and environment of satellite Flight Dynamics mission support. Over the past few years FDO has developed and implemented proactive quality assurance processes applied to each of the six phases of the Flight Dynamics mission support life cycle: systems and operations concept, system requirements and specifications, software development support, operations planing and training, launch support, and on-orbit mission operations. Rather than performing quality assurance as a final step after work is completed, quality assurance has been built in as work progresses in the form of process assurance. Process assurance activities occur throughout the Flight Dynamics mission support life cycle. The FDO Product Assurance Office developed process checklists for prephase process reviews, mission team orientations, in-progress reviews, and end-of-phase audits. This paper will outline the evolving history of FDO quality assurance approaches, discuss the tailoring of Computer Science Corporations's process assurance cycle procedures, describe some of the quality assurance approaches that have been or are being developed, and present some of the successful results.

From Discovery to Production: Biotechnology of Marine Fungi for the Production of New Antibiotics

PubMed Central

Silber, Johanna; Kramer, Annemarie; Labes, Antje; Tasdemir, Deniz

2016-01-01

Filamentous fungi are well known for their capability of producing antibiotic natural products. Recent studies have demonstrated the potential of antimicrobials with vast chemodiversity from marine fungi. Development of such natural products into lead compounds requires sustainable supply. Marine biotechnology can significantly contribute to the production of new antibiotics at various levels of the process chain including discovery, production, downstream processing, and lead development. However, the number of biotechnological processes described for large-scale production from marine fungi is far from the sum of the newly-discovered natural antibiotics. Methods and technologies applied in marine fungal biotechnology largely derive from analogous terrestrial processes and rarely reflect the specific demands of the marine fungi. The current developments in metabolic engineering and marine microbiology are not yet transferred into processes, but offer numerous options for improvement of production processes and establishment of new process chains. This review summarises the current state in biotechnological production of marine fungal antibiotics and points out the enormous potential of biotechnology in all stages of the discovery-to-development pipeline. At the same time, the literature survey reveals that more biotechnology transfer and method developments are needed for a sustainable and innovative production of marine fungal antibiotics. PMID:27455283

The Development of a Design and Construction Process Protocol to Support the Home Modification Process Delivered by Occupational Therapists

PubMed Central

Ormerod, Marcus; Newton, Rita

2018-01-01

Modifying the home environments of older people as they age in place is a well-established health and social care intervention. Using design and construction methods to redress any imbalance caused by the ageing process or disability within the home environment, occupational therapists are seen as the experts in this field of practice. However, the process used by occupational therapists when modifying home environments has been criticised for being disorganised and not founded on theoretical principles and concepts underpinning the profession. To address this issue, research was conducted to develop a design and construction process protocol specifically for home modifications. A three-stage approach was taken for the analysis of qualitative data generated from an online survey, completed by 135 occupational therapists in the UK. Using both the existing occupational therapy intervention process model and the design and construction process protocol as the theoretical frameworks, a 4-phase, 9-subphase design and construction process protocol for home modifications was developed. Overall, the study is innovative in developing the first process protocol for home modifications, potentially providing occupational therapists with a systematic and effective approach to the design and delivery of home modification services for older and disabled people. PMID:29682348

The Development of a Design and Construction Process Protocol to Support the Home Modification Process Delivered by Occupational Therapists.

PubMed

Russell, Rachel; Ormerod, Marcus; Newton, Rita

2018-01-01

Modifying the home environments of older people as they age in place is a well-established health and social care intervention. Using design and construction methods to redress any imbalance caused by the ageing process or disability within the home environment, occupational therapists are seen as the experts in this field of practice. However, the process used by occupational therapists when modifying home environments has been criticised for being disorganised and not founded on theoretical principles and concepts underpinning the profession. To address this issue, research was conducted to develop a design and construction process protocol specifically for home modifications. A three-stage approach was taken for the analysis of qualitative data generated from an online survey, completed by 135 occupational therapists in the UK. Using both the existing occupational therapy intervention process model and the design and construction process protocol as the theoretical frameworks, a 4-phase, 9-subphase design and construction process protocol for home modifications was developed. Overall, the study is innovative in developing the first process protocol for home modifications, potentially providing occupational therapists with a systematic and effective approach to the design and delivery of home modification services for older and disabled people.

Electromagnetic mixed waste processing system for asbestos decontamination

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kasevich, R.S.; Vaux, W.; Ulerich, N.

The overall objective of this three-phase program is to develop an integrated process for treating asbestos-containing material that is contaminated with radioactive and hazardous constituents. The integrated process will attempt to minimize processing and disposal costs. The objectives of Phase 1 were to establish the technical feasibility of asbestos decomposition, inorganic radionuclide nd heavy metal removal, and organic volatilization. Phase 1 resulted in the successful bench-scale demonstration of the elements required to develop a mixed waste treatment process for asbestos-containing material (ACM) contaminated with radioactive metals, heavy metals, and organics. Using the Phase 1 data, a conceptual process was developed.more » The Phase 2 program, currently in progress, is developing an integrated system design for ACM waste processing. The Phase 3 program will target demonstration of the mixed waste processing system at a DOE facility. The electromagnetic mixed waste processing system employs patented technologies to convert DOE asbestos to a non-hazardous, radionuclide-free, stable waste. The dry, contaminated asbestos is initially heated with radiofrequency energy to remove organic volatiles. Second,the radionuclides are removed by solvent extraction coupled with ion exchange solution treatment. Third, the ABCOV method converts the asbestos to an amorphous silica suspension at low temperature (100{degrees}C). Finally the amorphous silica is solidified for disposal.« less

A comparison of multi-metal deposition processes utilising gold nanoparticles and an evaluation of their application to 'low yield' surfaces for finger mark development.

PubMed

Fairley, C; Bleay, S M; Sears, V G; NicDaeid, N

2012-04-10

This paper reports a comparison of the effectiveness and practicality of using different multi-metal deposition processes for finger mark development. The work investigates whether modifications can be made to improve the performance of the existing process published by Schnetz. Secondly, we compare the ability of different multi-metal deposition processes to develop finger marks on a range of surfaces with that of other currently used development processes. All published multi-metal deposition processes utilise an initial stage of colloidal gold deposition followed by enhancement of the marks with using a physical developer. All possible combinations of colloidal gold and physical developer stages were tested. The method proposed by Schnetz was shown to be the most effective process, however a modification which reduced the pH of the enhancement solution was revealed to provide the best combination of effectiveness and practicality. In trials comparing the modified formulation with vacuum metal deposition, superglue and powder suspensions on surfaces which typically give low finger mark yields (cling film, plasticised vinyl, leather and masking tape), the modified method produced significantly better results over existing processes for cling film and plasticised vinyl. The modified formulation was found to be ineffective on both masking tape and leather. It is recommended that further tests be carried out on the modified multi-metal deposition formulation to establish whether it could be introduced for operational work on cling film material in particular. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Computer-Controlled Cylindrical Polishing Process for Large X-Ray Mirror Mandrels

NASA Technical Reports Server (NTRS)

Khan, Gufran S.; Gubarev, Mikhail; Speegle, Chet; Ramsey, Brian

2010-01-01

We are developing high-energy grazing incidence shell optics for hard-x-ray telescopes. The resolution of a mirror shells depends on the quality of cylindrical mandrel from which they are being replicated. Mid-spatial-frequency axial figure error is a dominant contributor in the error budget of the mandrel. This paper presents our efforts to develop a deterministic cylindrical polishing process in order to keep the mid-spatial-frequency axial figure errors to a minimum. Simulation software is developed to model the residual surface figure errors of a mandrel due to the polishing process parameters and the tools used, as well as to compute the optical performance of the optics. The study carried out using the developed software was focused on establishing a relationship between the polishing process parameters and the mid-spatial-frequency error generation. The process parameters modeled are the speeds of the lap and the mandrel, the tool s influence function, the contour path (dwell) of the tools, their shape and the distribution of the tools on the polishing lap. Using the inputs from the mathematical model, a mandrel having conical approximated Wolter-1 geometry, has been polished on a newly developed computer-controlled cylindrical polishing machine. The preliminary results of a series of polishing experiments demonstrate a qualitative agreement with the developed model. We report our first experimental results and discuss plans for further improvements in the polishing process. The ability to simulate the polishing process is critical to optimize the polishing process, improve the mandrel quality and significantly reduce the cost of mandrel production

ISLE (Image and Signal Processing LISP Environment) reference manual

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sherwood, R.J.; Searfus, R.M.

1990-01-01

ISLE is a rapid prototyping system for performing image and signal processing. It is designed to meet the needs of a person doing development of image and signal processing algorithms in a research environment. The image and signal processing modules in ISLE form a very capable package in themselves. They also provide a rich environment for quickly and easily integrating user-written software modules into the package. ISLE is well suited to applications in which there is a need to develop a processing algorithm in an interactive manner. It is straightforward to develop the algorithms, load it into ISLE, apply themore » algorithm to an image or signal, display the results, then modify the algorithm and repeat the develop-load-apply-display cycle. ISLE consists of a collection of image and signal processing modules integrated into a cohesive package through a standard command interpreter. ISLE developer elected to concentrate their effort on developing image and signal processing software rather than developing a command interpreter. A COMMON LISP interpreter was selected for the command interpreter because it already has the features desired in a command interpreter, it supports dynamic loading of modules for customization purposes, it supports run-time parameter and argument type checking, it is very well documented, and it is a commercially supported product. This manual is intended to be a reference manual for the ISLE functions The functions are grouped into a number of categories and briefly discussed in the Function Summary chapter. The full descriptions of the functions and all their arguments are given in the Function Descriptions chapter. 6 refs.« less

Demand driven salt clean-up in a molten salt fast reactor - Defining a priority list.

PubMed

Merk, B; Litskevich, D; Gregg, R; Mount, A R

2018-01-01

The PUREX technology based on aqueous processes is currently the leading reprocessing technology in nuclear energy systems. It seems to be the most developed and established process for light water reactor fuel and the use of solid fuel. However, demand driven development of the nuclear system opens the way to liquid fuelled reactors, and disruptive technology development through the application of an integrated fuel cycle with a direct link to reactor operation. The possibilities of this new concept for innovative reprocessing technology development are analysed, the boundary conditions are discussed, and the economic as well as the neutron physical optimization parameters of the process are elucidated. Reactor physical knowledge of the influence of different elements on the neutron economy of the reactor is required. Using an innovative study approach, an element priority list for the salt clean-up is developed, which indicates that separation of Neodymium and Caesium is desirable, as they contribute almost 50% to the loss of criticality. Separating Zirconium and Samarium in addition from the fuel salt would remove nearly 80% of the loss of criticality due to fission products. The theoretical study is followed by a qualitative discussion of the different, demand driven optimization strategies which could satisfy the conflicting interests of sustainable reactor operation, efficient chemical processing for the salt clean-up, and the related economic as well as chemical engineering consequences. A new, innovative approach of balancing the throughput through salt processing based on a low number of separation process steps is developed. Next steps for the development of an economically viable salt clean-up process are identified.

Guideline group composition and group processes: article 3 in Integrating and coordinating efforts in COPD guideline development. An official ATS/ERS workshop report.

PubMed

Kunz, Regina; Fretheim, Atle; Cluzeau, Françoise; Wilt, Timothy J; Qaseem, Amir; Lelgemann, Monika; Kelson, Marcia; Guyatt, Gordon; Schünemann, Holger J

2012-12-01

Professional societies, like many other organizations around the world, have recognized the need to use more rigorous processes to ensure that health care recommendations are informed by the best available research evidence. This is the third of a series of 14 articles that were prepared to advise guideline developers in respiratory and other diseases on considerations for group compositions and group processes in guideline development, and how this can be effectively integrated in the context of respiratory disease guidelines on a national and international level. We updated a review of the literature addressing group composition and group process, focusing on the following questions: 1. How to compose a functioning and representative guideline group; Who should be included in a guideline panel?; How to select organizations, groups, and individuals; What expertise is needed?; Consultation with non-included groups. 2. How to assure a functioning group process; How to make the process constructive; Balancing participation and finding agreement; Administrative support; What constitutes sufficient resources? Our conclusions are based on available evidence from published literature, experience from guideline developers, and workshop discussions. Formal studies addressing optimal processes in developing guidelines are limited, and experience from guideline organizations supplement the formal studies. When resources are available, guideline development groups should aim for multidisciplinary groups, including patients. Prerequisites for a multidisciplinary group include: a strong chair experienced in group facilitation with broad acceptance in the group, training the group in guideline methodology, and professional technical support. Formal consensus developing methods have proved effective in reaching agreement on the final recommendations.

Organizational management practices for achieving software process improvement

NASA Technical Reports Server (NTRS)

Kandt, Ronald Kirk

2004-01-01

The crisis in developing software has been known for over thirty years. Problems that existed in developing software in the early days of computing still exist today. These problems include the delivery of low-quality products, actual development costs that exceed expected development costs, and actual development time that exceeds expected development time. Several solutions have been offered to overcome out inability to deliver high-quality software, on-time and within budget. One of these solutions involves software process improvement. However, such efforts often fail because of organizational management issues. This paper discusses business practices that organizations should follow to improve their chances of initiating and sustaining successful software process improvement efforts.

Low-Cost Rapid Usability Testing: Its Application in Both Product Development and System Implementation.

PubMed

Kushniruk, Andre; Borycki, Elizabeth

2017-01-01

In recent years there has been considerable discussion around the need for certification and regulation of healthcare information technology (IT). In particular, the usability of the products being developed needs to be evaluated. This has included the application of standards designed to ensure the process of system development is user-centered and takes usability into consideration while a product is being developed. In addition to this, in healthcare, organizations in the United States and Europe have also addressed the need and requirement for product certification. However, despite these efforts there are continued reports of unusable and unsafe implementations. In this paper we discuss the need to not only include (and require) usability testing in the one-time development process of health IT products (such as EHRs), but we also argue for the need to additionally develop specific usability standards and requirements for usability testing during the implementation of vendor products (i.e. post product development) in healthcare settings. It is further argued that health IT products that may have been certified regarding their development process will still require application of usability testing in the process of implementing them in real hospital settings in order to ensure usability and safety. This is needed in order to ensure that the final result of both product development and implementation processes take into account and apply the latest usability principles and methods.

The life cycles of six multi-center adaptive clinical trials focused on neurological emergencies developed for the Advancing Regulatory Science initiative of the National Institutes of Health and US Food and Drug Administration: Case studies from the Adaptive Designs Accelerating Promising Treatments Into Trials Project.

PubMed

Guetterman, Timothy C; Fetters, Michael D; Mawocha, Samkeliso; Legocki, Laurie J; Barsan, William G; Lewis, Roger J; Berry, Donald A; Meurer, William J

2017-01-01

Clinical trials are complicated, expensive, time-consuming, and frequently do not lead to discoveries that improve the health of patients with disease. Adaptive clinical trials have emerged as a methodology to provide more flexibility in design elements to better answer scientific questions regarding whether new treatments are efficacious. Limited observational data exist that describe the complex process of designing adaptive clinical trials. To address these issues, the Adaptive Designs Accelerating Promising Treatments Into Trials project developed six, tailored, flexible, adaptive, phase-III clinical trials for neurological emergencies, and investigators prospectively monitored and observed the processes. The objective of this work is to describe the adaptive design development process, the final design, and the current status of the adaptive trial designs that were developed. To observe and reflect upon the trial development process, we employed a rich, mixed methods evaluation that combined quantitative data from visual analog scale to assess attitudes about adaptive trials, along with in-depth qualitative data about the development process gathered from observations. The Adaptive Designs Accelerating Promising Treatments Into Trials team developed six adaptive clinical trial designs. Across the six designs, 53 attitude surveys were completed at baseline and after the trial planning process completed. Compared to baseline, the participants believed significantly more strongly that the adaptive designs would be accepted by National Institutes of Health review panels and non-researcher clinicians. In addition, after the trial planning process, the participants more strongly believed that the adaptive design would meet the scientific and medical goals of the studies. Introducing the adaptive design at early conceptualization proved critical to successful adoption and implementation of that trial. Involving key stakeholders from several scientific domains early in the process appears to be associated with improved attitudes towards adaptive designs over the life cycle of clinical trial development.

Development and Processing Improvement of Aerospace Aluminum Alloys

NASA Technical Reports Server (NTRS)

Lisagor, W. Barry; Bales, Thomas T.

2007-01-01

This final report, in multiple presentation format, describes a comprehensive multi-tasked contract study to improve the overall property response of selected aerospace alloys, explore further a newly-developed and registered alloy, and correlate the processing, metallurgical structure, and subsequent properties achieved with particular emphasis on the crystallographic orientation texture developed. Modifications to plate processing, specifically hot rolling practices, were evaluated for Al-Li alloys 2195 and 2297, for the recently registered Al-Cu-Ag alloy, 2139, and for the Al-Zn-Mg-Cu alloy, 7050. For all of the alloys evaluated, the processing modifications resulted in significant improvements in mechanical properties. Analyses also resulted in an enhanced understanding of the correlation of processing, crystallographic texture, and mechanical properties.

Software Design Methodology Migration for a Distributed Ground System

NASA Technical Reports Server (NTRS)

Ritter, George; McNair, Ann R. (Technical Monitor)

2002-01-01

The Marshall Space Flight Center's (MSFC) Payload Operations Center (POC) ground system has been developed and has evolved over a period of about 10 years. During this time the software processes have migrated from more traditional to more contemporary development processes. The new Software processes still emphasize requirements capture, software configuration management, design documenting, and making sure the products that have been developed are accountable to initial requirements. This paper will give an overview of how the Software Process have evolved highlighting the positives as well as the negatives. In addition, we will mention the COTS tools that have been integrated into the processes and how the COTS have provided value to the project .

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clarke, Kester Diederik

The intent of this report is to document a procedure used at LANL for HIP bonding aluminum cladding to U-10Mo fuel foils using a formed HIP can for the Domestic Reactor Conversion program in the NNSA Office of Material, Management and Minimization, and provide some details that may not have been published elsewhere. The HIP process is based on the procedures that have been used to develop the formed HIP can process, including the baseline process developed at Idaho National Laboratory (INL). The HIP bonding cladding process development is summarized in the listed references. Further iterations with Babcock & Wilcoxmore » (B&W) to refine the process to meet production and facility requirements is expected.« less

Application of NASA-developed technology to the automatic control of municipal sewage treatment plants

NASA Technical Reports Server (NTRS)

Hiser, L. L.; Herrera, W. R.

1973-01-01

A search was made of NASA developed technology and commercial technology for process control sensors and instrumentation which would be applicable to the operation of municipal sewage treatment plants. Several notable items were found from which process control concepts were formulated that incorporated these items into systems to automatically operate municipal sewage treatment plants. A preliminary design of the most promising concept was developed into a process control scheme for an activated sludge treatment plant. This design included process control mechanisms for maintaining constant food to sludge mass (F/M) ratio, and for such unit processes as primary sedimentation, sludge wastage, and underflow control from the final clarifier.

An Extensible Information Grid for Risk Management

NASA Technical Reports Server (NTRS)

Maluf, David A.; Bell, David G.

2003-01-01

This paper describes recent work on developing an extensible information grid for risk management at NASA - a RISK INFORMATION GRID. This grid is being developed by integrating information grid technology with risk management processes for a variety of risk related applications. To date, RISK GRID applications are being developed for three main NASA processes: risk management - a closed-loop iterative process for explicit risk management, program/project management - a proactive process that includes risk management, and mishap management - a feedback loop for learning from historical risks that escaped other processes. This is enabled through an architecture involving an extensible database, structuring information with XML, schemaless mapping of XML, and secure server-mediated communication using standard protocols.

Biotechnology in Food Production and Processing

NASA Astrophysics Data System (ADS)

Knorr, Dietrich; Sinskey, Anthony J.

1985-09-01

The food processing industry is the oldest and largest industry using biotechnological processes. Further development of food products and processes based on biotechnology depends upon the improvement of existing processes, such as fermentation, immobilized biocatalyst technology, and production of additives and processing aids, as well as the development of new opportunities for food biotechnology. Improvements are needed in the characterization, safety, and quality control of food materials, in processing methods, in waste conversion and utilization processes, and in currently used food microorganism and tissue culture systems. Also needed are fundamental studies of the structure-function relationship of food materials and of the cell physiology and biochemistry of raw materials.

Intelligent process development of foam molding for the Thermal Protection System (TPS) of the space shuttle external tank

NASA Technical Reports Server (NTRS)

Bharwani, S. S.; Walls, J. T.; Jackson, M. E.

1987-01-01

A knowledge based system to assist process engineers in evaluating the processability and moldability of poly-isocyanurate (PIR) formulations for the thermal protection system of the Space Shuttle external tank (ET) is discussed. The Reaction Injection Molding- Process Development Advisor (RIM-PDA) is a coupled system which takes advantage of both symbolic and numeric processing techniques. This system will aid the process engineer in identifying a startup set of mold schedules and in refining the mold schedules to remedy specific process problems diagnosed by the system.

An approach to quantitative sustainability assessment in the early stages of process design.

PubMed

Tugnoli, Alessandro; Santarelli, Francesco; Cozzani, Valerio

2008-06-15

A procedure was developed for the quantitative assessment of key performance indicators suitable for the sustainability analysis of alternative processes, mainly addressing the early stages of process design. The methodology was based on the calculation of a set of normalized impact indices allowing a direct comparison of the additional burden of each process alternative on a selected reference area. Innovative reference criteria were developed to compare and aggregate the impact indicators on the basis of the site-specific impact burden and sustainability policy. An aggregation procedure also allows the calculation of overall sustainability performance indicators and of an "impact fingerprint" of each process alternative. The final aim of the method is to support the decision making process during process development, providing a straightforward assessment of the expected sustainability performances. The application of the methodology to case studies concerning alternative waste disposal processes allowed a preliminary screening of the expected critical sustainability impacts of each process. The methodology was shown to provide useful results to address sustainability issues in the early stages of process design.