Can a More User-Friendly Medicare Plan Finder Improve Consumers' Selection of Medicare Plans?

PubMed

Martino, Steven C; Kanouse, David E; Miranda, David J; Elliott, Marc N

2017-10-01

To evaluate the efficacy for consumers of two potential enhancements to the Medicare Plan Finder (MPF)-a simplified data display and a "quick links" home page designed to match the specific tasks that users seek to accomplish on the MPF. Participants (N = 641) were seniors and adult caregivers of seniors who were recruited from a national online panel. Participants browsed a simulated version of the MPF, made a hypothetical plan choice, and reported on their experience. Participants were randomly assigned to one of eight conditions in a fully factorial design: 2 home pages (quick links, current MPF home page) × 2 data displays (simplified, current MPF display) × 2 plan types (stand-alone prescription drug plan [PDP], Medicare Advantage plan with prescription drug coverage [MA-PD]). The quick links page resulted in more favorable perceptions of the MPF, improved users' understanding of the information, and increased the probability of choosing the objectively best plan. The simplified data display resulted in a more favorable evaluation of the website, better comprehension of the displayed information, and, among those choosing a PDP only, an increased probability of choosing the best plan. Design enhancements could markedly improve average website users' understanding, ability to use, and experience of using the MPF. © Health Research and Educational Trust.

The Impact of Additives on the Phosphorus, Potassium, and Sodium Content of Commonly Consumed Meat, Poultry, and Fish Products Among Patients With Chronic Kidney Disease.

PubMed

Parpia, Arti Sharma; L'Abbé, Mary; Goldstein, Marc; Arcand, Joanne; Magnuson, Bernadene; Darling, Pauline B

2018-03-01

Patients with chronic kidney disease (CKD) are advised to limit their dietary intake of phosphorus and potassium as hyperphosphatemia and hyperkalemia are both associated with an increased risk of mortality. There is uncertainty concerning the actual content of these minerals in the Canadian food supply, as phosphorus and potassium are increasingly being used as food additives. This study aimed to determine the impact of food additives on the chemically analyzed content of phosphorus, potassium, sodium, and protein in commonly consumed meat, poultry, and fish products (MPFs). Foods representing commonly consumed MPF identified by a food frequency questionnaire in dialysis patients were purchased from three major grocery store chains in Canada. MPF with and without phosphorus and potassium additives listed on their ingredient list (n = 76) as well as reference MPF that was additive free (n = 15) were chemically analyzed for phosphorus, potassium, sodium, and protein content according to Association of Analytical Community official methods. Phosphorus, potassium, and sodium additives were present on the ingredient list in 37%, 9%, and 72% of MPF, respectively. Among MPF categories that contained a phosphorus additive, phosphorus content was significantly (P < .05) higher in MPF with phosphorus additives versus MPF without phosphorus additives and MPF reference foods (median [min, max]): (270 [140, 500] mg/100 g) versus (200 [130, 510] mg/100 g) versus (210 [100, 260] mg/100 g), respectively. Among MPF categories containing a potassium additive, foods listing a potassium additive had significantly more (P < .05) potassium than foods that did not list potassium additives and reference foods (900 [750, 1100] mg/100 g) versus (325 [260, 470] mg/100 g) versus (420 [270, 450] mg/100 g). The use of additives in packaged MPF products as indicated by the ingredient list can significantly contribute to the dietary phosphorus and potassium loads in patients with CKD. Patients with CKD should be educated to avoid MPF foods listing phosphorus and/or potassium additives on the ingredient list, which may lead to improved dietary adherence. Copyright © 2017 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

Effect of dehydroleucodine on meiosis reinitiation in Bufo arenarum denuded oocytes.

PubMed

Sánchez Toranzo, G; Giordano, O S; López, L A; Bühler, M I

2007-05-01

In amphibian oocytes meiosis, the transition from G2 to M phase is regulated by the maturation promoting factor (MPF), a complex of the cyclin-dependent kinase p34/cdc2 and cyclin B. In immature oocytes there is an inactive complex (pre-MPF), in which cdc2 is phosphorylated on both Thr-161 and Thr-14/Tyr-15 residues. The dephosphorylation of Thr-14/Tyr-15 is necessary for the start of MPF activation and it is induced by the activation of cdc25 phosphatase. Late, to complete the activation, a small amount of active MPF induces an auto-amplification loop of MPF stimulation (MPF amplification). Dehydroleucodine (DhL) is a sesquiterpenic lactone that inhibits mammalian cell proliferation in G2. We asked whether DhL interferes with MPF activation. For this question, the effect of DhL (up to 30 microM) on the resumption of meiosis was evaluated, and visualized by germinal vesicle break down (GVBD), of Bufo arenarum oocytes induced in vitro by either: (i) removing follicle cells; (ii) progesterone stimulation; (iii) VG-content injection; or (iv) injection of mature cytoplasm. The results show that DhL induced GVBD inhibition, in a dose-dependent manner, in spontaneous and progesterone-induced oocyte maturation. Nevertheless, DhL at the doses assayed had no effect on GVBD induced by mature cytoplasm injection, but exerted an inhibitory effect on GVBD induced by GV content. On the basis of these results, we interpreted that DhL does not inhibit MPF amplification and that the target of DhL is any event in the early stages of the cdc25 activation cascade.

Paternal Multiple Partner Fertility and Environmental Chaos Among Unmarried Nonresident Fathers

PubMed Central

Petren, Raymond E.

2017-01-01

This study examined the association between paternal multiple partner fertility (MPF; having children with two or more partners) and indicators of environmental chaos (partnership instability, residential instability, work stability, material hardship, and perceived social support) among unmarried, non-resident fathers. Survey data from the Fragile Families and Child Wellbeing Study (N = 873) were used to compare unmarried non-resident fathers who experienced MPF to those who had children with one partner. Results show that paternal MPF is associated with most indicators of environmental chaos (greater partnership instability, residential instability, work instability, material hardship), but not social support. Results suggest that fathers who experience MPF face challenges beyond those of other non-resident fathers. Policies and interventions should address aspects of instability and hardship that are unique to paternal MPF in order to encourage fathers’ positive contributions to children and families. Directions for future research are discussed. PMID:29755155

Resolution-improved in situ DNA hybridization detection based on microwave photonic interrogation.

PubMed

Cao, Yuan; Guo, Tuan; Wang, Xudong; Sun, Dandan; Ran, Yang; Feng, Xinhuan; Guan, Bai-ou

2015-10-19

In situ bio-sensing system based on microwave photonics filter (MPF) interrogation method with improved resolution is proposed and experimentally demonstrated. A microfiber Bragg grating (mFBG) is used as sensing probe for DNA hybridization detection. Different from the traditional wavelength monitoring technique, we use the frequency interrogation scheme for resolution-improved bio-sensing detection. Experimental results show that the frequency shift of MPF notch presents a linear response to the surrounding refractive index (SRI) change over the range of 1.33 to 1.38, with a SRI resolution up to 2.6 × 10(-5) RIU, which has been increased for almost two orders of magnitude compared with the traditional fundamental mode monitoring technique (~3.6 × 10(-3) RIU). Due to the high Q value (about 27), the whole process of DNA hybridization can be in situ monitored. The proposed MPF-based bio-sensing system provides a new interrogation method over the frequency domain with improved sensing resolution and rapid interrogation rate for biochemical and environmental measurement.

Mars Pathfinder Spacecraft, Lander, and Rover Testing in Simulated Deep Space and Mars Surface Environments

NASA Technical Reports Server (NTRS)

Johnson, Kenneth R.

1997-01-01

The Mars Pathfinder (MPF) Spacecraft was built and tested at the Jet Propulsion Laboratory during 1995/96. MPF is scheduled to launch in December 1996 and to land on Mars on July 4, 1997. The testing program for MPF required subjecting the mission hardware to both deep space and Mars surface conditions. A series of tests were devised and conducted from 1/95 to 7/96 to study the thermal response of the MPF spacecraft to the environmental conditions in which it will be exposed during the cruise phase (on the way to Mars) and the lander phase (landed on Mars) of the mission. Also, several tests were conducted to study the thermal characteristics of the Mars rover, Sojourner, under Mars surface environmental conditions. For these tests, several special test fixtures and methods were devised to simulate the required environmental conditions. Creating simulated Mars surface conditions was a challenging undertaking since Mars' surface is subjected to diurnal cycling between -20 C and -85 C, with windspeeds to 20 m/sec, occurring in an 8 torr CO2 atmosphere. This paper describes the MPF test program which was conducted at JPL to verify the MPF thermal design.

Unintended Relevance: The Role of the Stryker Brigade Combat Team in the Decisive Action Environment

DTIC Science & Technology

2017-05-25

Systems , 30MM 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF PAGES 19a. NAME OF RESPONSIBLE PERSON Walter C. Gray II...Facilities- Policy FCS Future Combat System FM Field Manual FMTV Family of Medium Tactical Vehicles GCV Ground Combat Vehicle GWOT...Vehicle MGS Mobile Gun System MPF Mobile Protected Firepower NATO North Atlantic Treaty Organization ONS Operational Needs Statement RPG

Translational control by cytoplasmic polyadenylation during Xenopus oocyte maturation: characterization of cis and trans elements and regulation by cyclin/MPF.

PubMed

McGrew, L L; Richter, J D

1990-11-01

The expression of certain maternal mRNAs during oocyte maturation is regulated by cytoplasmic polyadenylation. To understand this process, we have focused on a maternal mRNA from Xenopus termed G10. This mRNA is stored in the cytoplasm of stage 6 oocytes until maturation when the process of poly(A) elongation stimulates its translation. Deletion analysis of the 3' untranslated region of G10 RNA has revealed that two sequence elements, UUUUUUAU and AAUAAA were both necessary and sufficient for polyadenylation and polysomal recruitment. In this communication, we have defined the U-rich region that is optimal for polyadenylation as UUUUUUAUAAAG, henceforth referred to as the cytoplasmic polyadenylation element (CPE). We have also identified unique sequence requirements in the 3' terminus of the RNA that can modulate polyadenylation even in the presence of wild-type cis elements. A time course of cytoplasmic polyadenylation in vivo shows that it is an early event of maturation and that it requires protein synthesis within the first 15 min of exposure to progesterone. MPF and cyclin can both induce polyadenylation but, at least with respect to MPF, cannot obviate the requirement for protein synthesis. To identify factors that may be responsible for maturation-specific polyadenylation, we employed extracts from oocytes and unfertilized eggs, the latter of which correctly polyadenylates exogenously added RNA. UV crosslinking demonstrated that an 82 kd protein binds to the U-rich CPE in egg, but not oocyte, extracts. The data suggest that progesterone, either in addition to or through MPF/cyclin, induces the synthesis of a factor during very early maturation that stimulates polyadenylation.(ABSTRACT TRUNCATED AT 250 WORDS)

A reconfigurable microwave photonic filter with flexible tunability using a multi-wavelength laser and a multi-channel phase-shifted fiber Bragg grating

NASA Astrophysics Data System (ADS)

Shi, Nuannuan; Hao, Tengfei; Li, Wei; Zhu, Ninghua; Li, Ming

2018-01-01

We propose a photonic scheme to realize a reconfigurable microwave photonic filter (MPF) with flexible tunability using a multi-wavelength laser (MWL) and a multi-channel phase-shifted fiber Bragg grating (PS-FBG). The proposed MPF is capable of performing reconfigurability including single bandpass filter, two independently bandpass filter and a flat-top bandpass filter. The performance such as the central frequency and the bandwidth of passband is tuned by controlling the wavelengths of the MWL. In the MPF, The light waves from a MWL are sent to a phase modulator (PM) to generate the phase-modulated optical signals. By applying a multi-channel PS-FBG, which has a series of narrow notches in the reflection spectrum with the free spectral range (FSR) of 0.8 nm, the +1st sidebands are removed in the notches and the phased-modulated signals are converted to the intensity-modulated signals without beating signals generation between each two optical carriers. The proposed MPF is also experimentally verified. The 3-dB bandwidth of the MPF is broadened from 35 MHz to 135 MHz and the magnitude deviation of the top from the MPF is less than 0.2 dB within the frequency tunable range from 1 GHz to 5 GHz.

The influence of electromyographic recording methods and the innervation zone on the mean power frequency-torque relationships.

PubMed

Herda, Trent J; Zuniga, Jorge M; Ryan, Eric D; Camic, Clayton L; Bergstrom, Haley C; Smith, Doug B; Weir, Joseph P; Cramer, Joel T; Housh, Terry J

2015-06-01

This study examined the effects of electromyographic (EMG) recording methods and innervation zone (IZ) on the mean power frequency (MPF)-torque relationships. Nine subjects performed isometric ramp muscle actions of the leg extensors from 5% to 100% of maximal voluntary contraction with an eight channel linear electrode array over the IZ of the vastus lateralis. The slopes were calculated from the log-transformed monopolar and bipolar EMG MPF-torque relationships for each channel and subject and 95% confidence intervals (CI) were constructed around the slopes for each relationship and the composite of the slopes. Twenty-two to 55% of the subjects exhibited 95% CIs that did not include a slope of zero for the monopolar EMG MPF-torque relationships while 25-75% of the subjects exhibited 95% CIs that did not include a slope of zero for the bipolar EMG MPF-torque relationships. The composite of the slopes from the EMG MPF-torque relationships were not significantly different from zero for any method or channel, however, the method and IZ location slightly influenced the number of significant slopes on a subject-by-subject basis. The log-transform model indicated that EMG MPF-torque patterns were nonlinear regardless of recording method or distance from the IZ. Copyright © 2015 Elsevier Ltd. All rights reserved.

The M Phase Kinase Greatwall (Gwl) Promotes Inactivation of PP2A/B55δ, a Phosphatase Directed Against CDK Phosphosites

PubMed Central

Castilho, Priscila V.; Williams, Byron C.; Mochida, Satoru; Zhao, Yong

2009-01-01

We have previously shown that Greatwall kinase (Gwl) is required for M phase entry and maintenance in Xenopus egg extracts. Here, we demonstrate that Gwl plays a crucial role in a novel biochemical pathway that inactivates, specifically during M phase, “antimitotic” phosphatases directed against phosphorylations catalyzed by cyclin-dependent kinases (CDKs). A major component of this phosphatase activity is heterotrimeric PP2A containing the B55δ regulatory subunit. Gwl is activated during M phase by Cdk1/cyclin B (MPF), but once activated, Gwl promotes PP2A/B55δ inhibition with no further requirement for MPF. In the absence of Gwl, PP2A/B55δ remains active even when MPF levels are high. The removal of PP2A/B55δ corrects the inability of Gwl-depleted extracts to enter M phase. These findings support the hypothesis that M phase requires not only high levels of MPF function, but also the suppression, through a Gwl-dependent mechanism, of phosphatase(s) that would otherwise remove MPF-driven phosphorylations. PMID:19793917

Mixture of Peanut Skin Extract and Fish Oil Improves Memory in Mice via Modulation of Anti-Oxidative Stress and Regulation of BDNF/ERK/CREB Signaling Pathways

PubMed Central

Xiang, Lan; Cao, Xue-Li; Xing, Tian-Yan; Mori, Daisuke; Tang, Rui-Qi; Li, Jing; Gao, Li-Juan; Qi, Jian-Hua

2016-01-01

Long-term use of fish oil (FO) is known to induce oxidative stress and increase the risk of Alzheimer’s disease in humans. In the present study, peanut skin extract (PSE), which has strong antioxidant capacity, was mixed with FO to reduce its side effects while maintaining its beneficial properties. Twelve-week Institute of Cancer Research (ICR) mice were used to conduct animal behavior tests in order to evaluate the memory-enhancing ability of the mixture of peanut skin extract and fish oil (MPF). MPF significantly increased alternations in the Y-maze and cognitive index in the novel object recognition test. MPF also improved performance in the water maze test. We further sought to understand the mechanisms underlying these effects. A significant decrease in superoxide dismutase (SOD) activity and an increase in malonyldialdehyde (MDA) in plasma were observed in the FO group. The MPF group showed reduced MDA level and increased SOD activity in the plasma, cortex and hippocampus. Furthermore, the gene expression levels of brain-derived neurotrophic factor (BDNF) and cAMP responsive element-binding protein (CREB) in the hippocampus were increased in the MPF group, while phosphorylation of protein kinase B (AKT), extracellular signal-regulated kinase (ERK) and CREB in the hippocampus were enhanced. MPF improves memory in mice via modulation of anti-oxidative stress and activation of BDNF/ERK/CREB signaling pathways. PMID:27136583

Magnetic Enrichment of Dendritic Cell Vaccine in Lymph Node with Fluorescent-Magnetic Nanoparticles Enhanced Cancer Immunotherapy

PubMed Central

Jin, Honglin; Qian, Yuan; Dai, Yanfeng; Qiao, Sha; Huang, Chuan; Lu, Lisen; Luo, Qingming; Chen, Jing; Zhang, Zhihong

2016-01-01

Dendritic cell (DC) migration to the lymph node is a key component of DC-based immunotherapy. However, the DC homing rate to the lymphoid tissues is poor, thus hindering the DC-mediated activation of antigen-specific T cells. Here, we developed a system using fluorescent magnetic nanoparticles (α-AP-fmNPs; loaded with antigen peptide, iron oxide nanoparticles, and indocyanine green) in combination with magnetic pull force (MPF) to successfully manipulate DC migration in vitro and in vivo. α-AP-fmNPs endowed DCs with MPF-responsiveness, antigen presentation, and simultaneous optical and magnetic resonance imaging detectability. We showed for the first time that α-AP-fmNP-loaded DCs were sensitive to MPF, and their migration efficiency could be dramatically improved both in vitro and in vivo through MPF treatment. Due to the enhanced migration of DCs, MPF treatment significantly augmented antitumor efficacy of the nanoparticle-loaded DCs. Therefore, we have developed a biocompatible approach with which to improve the homing efficiency of DCs and subsequent anti-tumor efficacy, and track their migration by multi-modality imaging, with great potential applications for DC-based cancer immunotherapy. PMID:27698936

Photonic crystal nanocavity assisted rejection ratio tunable notch microwave photonic filter

PubMed Central

Long, Yun; Xia, Jinsong; Zhang, Yong; Dong, Jianji; Wang, Jian

2017-01-01

Driven by the increasing demand on handing microwave signals with compact device, low power consumption, high efficiency and high reliability, it is highly desired to generate, distribute, and process microwave signals using photonic integrated circuits. Silicon photonics offers a promising platform facilitating ultracompact microwave photonic signal processing assisted by silicon nanophotonic devices. In this paper, we propose, theoretically analyze and experimentally demonstrate a simple scheme to realize ultracompact rejection ratio tunable notch microwave photonic filter (MPF) based on a silicon photonic crystal (PhC) nanocavity with fixed extinction ratio. Using a conventional modulation scheme with only a single phase modulator (PM), the rejection ratio of the presented MPF can be tuned from about 10 dB to beyond 60 dB. Moreover, the central frequency tunable operation in the high rejection ratio region is also demonstrated in the experiment. PMID:28067332

Photonic crystal nanocavity assisted rejection ratio tunable notch microwave photonic filter

NASA Astrophysics Data System (ADS)

Long, Yun; Xia, Jinsong; Zhang, Yong; Dong, Jianji; Wang, Jian

2017-01-01

Driven by the increasing demand on handing microwave signals with compact device, low power consumption, high efficiency and high reliability, it is highly desired to generate, distribute, and process microwave signals using photonic integrated circuits. Silicon photonics offers a promising platform facilitating ultracompact microwave photonic signal processing assisted by silicon nanophotonic devices. In this paper, we propose, theoretically analyze and experimentally demonstrate a simple scheme to realize ultracompact rejection ratio tunable notch microwave photonic filter (MPF) based on a silicon photonic crystal (PhC) nanocavity with fixed extinction ratio. Using a conventional modulation scheme with only a single phase modulator (PM), the rejection ratio of the presented MPF can be tuned from about 10 dB to beyond 60 dB. Moreover, the central frequency tunable operation in the high rejection ratio region is also demonstrated in the experiment.

Photonic crystal nanocavity assisted rejection ratio tunable notch microwave photonic filter.

PubMed

Long, Yun; Xia, Jinsong; Zhang, Yong; Dong, Jianji; Wang, Jian

2017-01-09

Driven by the increasing demand on handing microwave signals with compact device, low power consumption, high efficiency and high reliability, it is highly desired to generate, distribute, and process microwave signals using photonic integrated circuits. Silicon photonics offers a promising platform facilitating ultracompact microwave photonic signal processing assisted by silicon nanophotonic devices. In this paper, we propose, theoretically analyze and experimentally demonstrate a simple scheme to realize ultracompact rejection ratio tunable notch microwave photonic filter (MPF) based on a silicon photonic crystal (PhC) nanocavity with fixed extinction ratio. Using a conventional modulation scheme with only a single phase modulator (PM), the rejection ratio of the presented MPF can be tuned from about 10 dB to beyond 60 dB. Moreover, the central frequency tunable operation in the high rejection ratio region is also demonstrated in the experiment.

Effects of the innervation zone on the time and frequency domain parameters of the surface electromyographic signal.

PubMed

Smith, Cory M; Housh, Terry J; Herda, Trent J; Zuniga, Jorge M; Ryan, Eric D; Camic, Clayton L; Bergstrom, Haley C; Smith, Doug B; Weir, Joseph P; Cramer, Joel T; Hill, Ethan C; Cochrane, Kristen C; Jenkins, Nathaniel D M; Schmidt, Richard J; Johnson, Glen O

2015-08-01

The purposes of the present study were to examine the effects of electrode placements over, proximal, and distal to the innervation zone (IZ) on electromyographic (EMG) amplitude (RMS) and frequency (MPF) responses during: (1) a maximal voluntary isometric contraction (MVIC), and; (2) a sustained, submaximal isometric muscle action. A linear array was used to record EMG signals from the vastus lateralis over the IZ, 30mm proximal, and 30mm distal to the IZ during an MVIC and a sustained isometric muscle action of the leg extensors at 50% MVIC. During the MVIC, lower EMG RMS (p>0.05) and greater EMG MPF (p<0.05) values were recorded over the IZ compared to away from the IZ, however, no differences in slope coefficients for the EMG RMS and MPF versus time relationships over, proximal, and distal to the IZ occurred. Thus, the results of the present study indicated that during an MVIC, EMG RMS and MPF values recorded over the IZ are not comparable to those away from the IZ. However, the rates of fatigue-induced changes in EMG RMS and MPF during sustained, submaximal isometric muscle actions of the leg extensors were the same regardless of the electrode placement locations relative to the IZ. Copyright © 2015 Elsevier Ltd. All rights reserved.

Regulation of cAMP on the first mitotic cell cycle of mouse embryos.

PubMed

Yu, Aiming; Zhang, Zhe; Bi, Qiang; Sun, Bingqi; Su, Wenhui; Guan, Yifu; Mu, Runqing; Miao, Changsheng; Zhang, Jie; Yu, Bingzhi

2008-03-01

Mitosis promoting factor (MPF) plays a central role during the first mitosis of mouse embryo. We demonstrated that MPF activity increased when one-cell stage mouse embryo initiated G2/M transition following the decrease of cyclic adenosine 3', 5'-monophosphate (cAMP) and cAMP-dependent protein kinase (PKA) activity. When cAMP and PKA activity increases again, MPF activity decreases and mouse embryo starts metaphase-anaphase transition. In the downstream of cAMP/PKA, there are some effectors such as polo-like kinase 1 (Plk1), Cdc25, Mos (mitogen-activated protein kinase kinase kinase), MEK (mitogen-activated protein kinase kinase), mitogen-activated protein kinase (MAPK), Wee1, anaphase-promoting complex (APC), and phosphoprotein phosphatase that are involved in the regulation of MPF activity. Here, we demonstrated that following activation of MPF, MAPK activity was steady, whereas Plk1 activity fluctuated during the first cell cycle. Plk1 activity was the highest at metaphase and decreased at metaphase-anaphase transition. Further, we established a mathematical model using Gepasi algorithm and the simulation was in agreement with the experimental data. Above all the evidences, we suggested that cAMP and PKA might be the upstream factors which were included in the regulation of the first cell cycle development of mouse embryo. Copyright 2007 Wiley-Liss, Inc.

Chemical activation in Rhinella arenarum oocytes: effect of dehydroleucodine (DhL) and its hydrogenated derivative (2H-DhL).

PubMed

Medina, M F; Bühler, M I; Sánchez-Toranzo, G

2015-12-01

Mature oocytes are arrested in metaphase II due to the presence of high levels of active maturation promoting factor (MPF). After fertilization, active MPF levels decline abruptly, enabling oocytes to complete meiosis II. One of the first and universal events of oocyte activation is an increase in cytosolic Ca2+ that would be responsible for MPF inactivation. Mature oocytes can also be activated by parthenogenetic activation. The aims of this work are to test the ability of dehydroleucodine (DhL) and its hydrogenated derivative 11,13-dihydro-dehydroleucodine (2H-DhL) to induce chemical activation in amphibian oocytes and to study the participation of calcium in the process. Results indicated that DhL and 2H-DhL induced oocyte activation in a dose-dependent manner. After 90 min of treatment, DhL 36 μM was able to induce 95% activation, while 2H-DhL 36 μM was less active, with only 40% activation. Our results suggest that DhL induced the inhibition of MPF activity, probably by an increase in intracellular Ca2+ concentration. Extracellular Ca2+ would not be significant, although Ca2+ release from intracellular stores is critical. In this sense, IP3Rs and RyRs were involved in the Ca2+ transient induced by lactones. In this species, RyRs appears to be the largest contributor to Ca2+ release in DhL-induced activation. Although more studies are needed on the mechanism of action through which these lactones induce oocyte activation in Rhinella arenarum, the results of this research provide interesting perspectives for the use of these lactones as chemical activators in in vitro fertilization and cloning.

Multipartnered Fertility and Depression among Fragile Families

ERIC Educational Resources Information Center

Turney, Kristin; Carlson, Marcia J.

2011-01-01

We used data from the Fragile Families and Child Wellbeing Study to examine the association between multipartnered fertility (MPF)--when parents have children with more than one partner--and depression. Random-effects models suggested that MPF is associated with a greater likelihood of depression, net of family structure and other covariates.…

Generating Adaptive Behaviour within a Memory-Prediction Framework

PubMed Central

Rawlinson, David; Kowadlo, Gideon

2012-01-01

The Memory-Prediction Framework (MPF) and its Hierarchical-Temporal Memory implementation (HTM) have been widely applied to unsupervised learning problems, for both classification and prediction. To date, there has been no attempt to incorporate MPF/HTM in reinforcement learning or other adaptive systems; that is, to use knowledge embodied within the hierarchy to control a system, or to generate behaviour for an agent. This problem is interesting because the human neocortex is believed to play a vital role in the generation of behaviour, and the MPF is a model of the human neocortex. We propose some simple and biologically-plausible enhancements to the Memory-Prediction Framework. These cause it to explore and interact with an external world, while trying to maximize a continuous, time-varying reward function. All behaviour is generated and controlled within the MPF hierarchy. The hierarchy develops from a random initial configuration by interaction with the world and reinforcement learning only. Among other demonstrations, we show that a 2-node hierarchy can learn to successfully play “rocks, paper, scissors” against a predictable opponent. PMID:22272231

Mobility power flow analysis of an L-shaped plate structure subjected to distributed loading

NASA Technical Reports Server (NTRS)

Cuschieri, J. M.; Cimmerman, B.

1990-01-01

An analytical investigation based in the Mobility Power Flow (MPF) method is presented for the determination of the vibrational response and power flow for two coupled flat plate structures in an L-shaped configuration, subjected to distributed excitation. The principle of the MPF method consists of dividing the global structure into a series of subsystems coupled together using mobility functions. Each separate subsystem is analyzed independently to determine the structural mobility functions for the junction and excitation locations. The mobility functions, together with the characteristics of the junction between the subsystems, are then used to determine the response of the global structure and the MPF. In the considered coupled plate structure, MPF expressions are derived for distributed mechanical excitation which is independent of the structure response. However using a similar approach with some modifications excitation by an acoustic plane wave can be considered. Some modifications are required to deal with the latter case are necessary because the forces (acoustic pressure) acting on the structure are dependent on the response of the structure due to the presence of the scattered pressure.

Effects of Velocity on Electromyographic, Mechanomyographic, and Torque Responses to Repeated Eccentric Muscle Actions.

PubMed

Hill, Ethan C; Housh, Terry J; Camic, Clayton L; Smith, Cory M; Cochrane, Kristen C; Jenkins, Nathaniel D M; Cramer, Joel T; Schmidt, Richard J; Johnson, Glen O

2016-06-01

The purposes of this study were to examine the effects of the velocity of repeated eccentric muscle actions on the torque and neuromuscular responses during maximal isometric and eccentric muscle actions. Twelve resistance-trained men performed 30 repeated, maximal, eccentric, isokinetic muscle actions at randomly ordered velocities of 60, 120, or 180°·s on separate days. Maximal voluntary isometric contractions (MVICs) were performed before (pretest) and after (posttest) the repeated eccentric muscle actions on each day. Eccentric isokinetic peak torque (EIPT) values were the averages of the first 3 and last 3 repetitions of the 30 repeated eccentric muscle actions. During the EIPT and MVIC muscle actions, electromyographic (EMG) and mechanomyographic (MMG) amplitude (EMG AMP and MMG AMP) and mean power frequency (EMG MPF and MMG MPF) values were assessed. These results indicated that the repeated eccentric muscle actions had no effects on EIPT, or the EMG AMP, EMG MPF, or MMG MPF values assessed during the EIPT muscle actions, but decreased MMG AMP. The repeated eccentric muscle actions, however, decreased MVIC torque, and also the EMG AMP and MMG MPF values assessed during the MVIC muscle actions, but increased MMG AMP. The results indicated that the velocity of the repeated eccentric muscle actions affected the MVIC torque responses, but not EIPT or any of the neuromuscular parameters. Furthermore, there are differences in the torque and neuromuscular responses for isometric vs. eccentric muscle actions after repeated eccentric muscle actions.

The effect of epoch length on time and frequency domain parameters of electromyographic and mechanomyographic signals.

PubMed

Keller, Joshua L; Housh, Terry J; Camic, Clayton L; Bergstrom, Haley C; Smith, Doug B; Smith, Cory M; Hill, Ethan C; Schmidt, Richard J; Johnson, Glen O; Zuniga, Jorge M

2018-06-01

The selection of epoch lengths affects the time and frequency resolution of electromyographic (EMG) and mechanomyographic (MMG) signals, as well as decisions regarding the signal processing techniques to use for determining the power density spectrum. No previous studies, however, have examined the effects of epoch length on parameters of the MMG signal. The purpose of this study was to examine the differences between epoch lengths for EMG amplitude, EMG mean power frequency (MPF), MMG amplitude, and MMG MPF from the VL and VM muscles during MVIC muscle actions as well as at each 10% of the time to exhaustion (TTE) during a continuous isometric muscle action of the leg extensors at 50% of MVIC. During the MVIC trial, there were no significant (p > 0.05) differences between epoch lengths (0.25, 0.50, 1.00, and 2.00-s) for mean absolute values for any of the EMG or MMG parameters. During the submaximal, sustained muscle action, however, absolute MMG amplitude and MMG MPF were affected by the length of epoch. All epoch related differences were eliminated by normalizing the absolute values to MVIC. These findings supported normalizing EMG and MMG parameter values to MVIC and utilizing epoch lengths that ranged from 0.25 to 2.00-s. Copyright © 2018 Elsevier Ltd. All rights reserved.

Mapping Rock and Soil Units in the MPF IMP SuperPan Using a Kohonen Self Organizing Map

NASA Technical Reports Server (NTRS)

Farrand, W.; Merenyi, E.; Murchie, S.; Barnouin-Jha, O.; Johnson, J.

2004-01-01

The 1997 Mars Pathfinder mission provided information on a site in the Ares Vallis floodplain. Initial analysis of multispectral data from the Imager for Mars Pathfinder (IMP) indicated the presence of only a single rock type, the 'gray rock' spectral class and various coated variants thereof (e.g., 'maroon rock'). Continued analysis of the IMP 'SuperPan' mosaic has confirmed multiple examples of a second 'black rock' spectral class existing as small cobbles in the near field and as boulders in the far field. These results are consistent with recent analysis of MGS Thermal Emission Spectrometer (TES) data which indicates that there is likely a mix of both 'Surface Type 1' (ST1) and 'Surface Type 2' (ST2) spectral classes at the MPF landing site. Nominally, the black rock spectral class would correspond to ST1 (basalts) and 'gray rock' would correspond to ST2 (andesites). Orbital remote sensing has also revealed the pervasive presence of layering on Mars. Recently it was suggested that there are extensive outcrops of the black rock spectral class in the SuperPan far field on the flanks of the Twin Peaks and on the rim of Big Crater. These authors suggested that these exposures represented outcrops of black rock from beneath a surficial, flood deposited layer. In this work, we have reexamined the MPF IMP SuperPan mosaic using an artificial neural network self organizing map (SOM) processing architecture in order to classify the distribution of spectral classes within the SuperPan. In this paper, we present initial results from that work and draw specific attention to a subset of the identified spectral classes in order to address questions relating to whether there are extensive exposures of black rock in the IMP far field, what other materials might be exposed in the far field, and what evidence there is for subsurface layering at the MPF landing site.

High speed and high resolution interrogation of a fiber Bragg grating sensor based on microwave photonic filtering and chirped microwave pulse compression.

PubMed

Xu, Ou; Zhang, Jiejun; Yao, Jianping

2016-11-01

High speed and high resolution interrogation of a fiber Bragg grating (FBG) sensor based on microwave photonic filtering and chirped microwave pulse compression is proposed and experimentally demonstrated. In the proposed sensor, a broadband linearly chirped microwave waveform (LCMW) is applied to a single-passband microwave photonic filter (MPF) which is implemented based on phase modulation and phase modulation to intensity modulation conversion using a phase modulator (PM) and a phase-shifted FBG (PS-FBG). Since the center frequency of the MPF is a function of the central wavelength of the PS-FBG, when the PS-FBG experiences a strain or temperature change, the wavelength is shifted, which leads to the change in the center frequency of the MPF. At the output of the MPF, a filtered chirped waveform with the center frequency corresponding to the applied strain or temperature is obtained. By compressing the filtered LCMW in a digital signal processor, the resolution is improved. The proposed interrogation technique is experimentally demonstrated. The experimental results show that interrogation sensitivity and resolution as high as 1.25 ns/με and 0.8 με are achieved.

Preliminary Results of the 115 kJ Dense Plasma Focus Device IR-MPF-100

NASA Astrophysics Data System (ADS)

Salehizadeh, A.; Sadighzadeh, A.; Movahhed, M. Sedaghat; Zaeem, A. A.; Heidarnia, A.; Sabri, R.; Mahmoudi, M. Bakhshzad; Rahimi, H.; Rahimi, S.; Johari, E.; Torabi, M.; Damideh, V.

2013-04-01

This work summarizes the design and construction of the first Iranian 115 kJ Mather type plasma focus (PF) machine (IR-MPF-100). This machine consists of a 6.25 cm radius and 22 cm height brass made anode with a 50 mm height insulator which separates the anode and cathode electrodes. Twelve copper made 22 cm height rods play the role of cathode with 10.2 cm radius. Twenty four 6 μF capacitors were used with the maximum charging voltage of 40 kV (maximum energy of 115 kJ) as the capacitor bank and maximum theoretical current around 1.224 MA. The total inductance of the system is 120 nH. By using NE-102 plastic Scintillator, Rogowski coil, current and voltage probes, hard X-ray, current derivative, current and voltage signals of IR-MPF-100 were measured. The primary result of neutron detection by neutron activation counter represents approximately 109 neutrons per shot at 65 kJ discharge energy while using deuterium filling gas. Also IR-MPF-100 PF has been tested successfully at 90 kJ by using the argon gas.

A precipitation organization climatology for North Carolina: Development and GIS-based analysis

NASA Astrophysics Data System (ADS)

Zarzar, Christopher M.

A climatology of precipitation organization is developed for the Southeast United States and is analyzed in a GIS framework. This climatology is created using four years (2009-2012) of daily-averaged data from the NOAA high-resolution multi-sensor precipitation estimation (MPE) dataset, specifically the radar-based quantitative precipitation estimation (QPE) product and the mosaic reflectivity. The analysis associates precipitation at each pixel with the spatial scale of precipitation organization, either a mesoscale precipitation feature (MPF) or isolated storm. While the long-term averaged precipitation totals of these systems may be similar, their hydrological and climatological impacts are very different, especially at a local scale. The classification of these modes of precipitation organization in the current precipitation climatology provides information beyond standard precipitation climatologies that will benefit a range of hydrological and climatological applications. This study focuses on North Carolina and takes advantage of a GIS framework to examine hydrological responses to different modes of precipitation organization. Specifically, the following questions are addressed: First, what are the discharge response characteristics to precipitation events in different watersheds across the state, from the mountains to the coastal plain? Second, what are the different impacts on watershed discharge between MPF precipitation and isolated precipitation? We first present seasonal and annual composites of precipitation and duration of MPF and isolated storms across three regions of North Carolina: the western mountains, the central Piedmont, and the eastern coastal plain. Further analysis in a GIS framework provides information about the impacts this seasonal and geographic variability in precipitation has on watershed discharge. This analysis defines five watersheds in North Carolina based on five North Carolina river basins using ArcGIS watershed delineation techniques. The amount of precipitation that comes from MPF and isolated convection in each watershed is estimated using ArcGIS and QPE data from a climatology of precipitation organization. Comparing these estimates to USGS streamflow data provides information about the impact different modes of precipitation organization have on watershed discharge in North Carolina. It was found that precipitation from MPF and isolated events had substantial spatial and temporal variability. While MPF average daily precipitation was greatest in the winter, isolated average daily precipitation was greatest in the summer. This resulted in seasonal and spatial variations in precipitation-discharge correlations. Precipitation originating from MPF events produced stronger precipitation-discharge correlations in the winter and fall than in the summer and spring, while most isolated precipitation-discharge correlations were relatively weak. Additionally, the watersheds in the western mountains experienced stronger correlations with a shorter time lag than coastal watersheds. It was determined that much of this spatial variability in precipitation-discharge correlations could be explained by watershed characteristics. Overall, it was found that MPF precipitation is the main mode of precipitation organization that drives daily watershed discharge, and differences in watershed precipitation-discharge lag times can be best explained by the watershed characteristics.

Motor unit recruitment and EMG power spectra during ramp contractions of a bifunctional muscle.

PubMed

Dupont, L; Gamet, D; Pérot, C

2000-08-01

Surface electromyograms (EMGs) were analysed on the short and long head of the biceps brachii (BBSH and BBLH) during single (F and S) or dual (F+S) flexion and supination tasks. It was confirmed, by the analysis of EMG root-mean-square (RMS) values, that the highest activations of BBSH and BBLH were obtained during a maximal dual task. This study was essentially concerned with the analysis of power spectra data obtained during progressive or ramp contractions (RCs). The shape of the power spectra established during the first second of the RCs differs between F, S and F+S tasks. Differences in mean power frequency (MPF) calculated during RCs would be representative of a recruitment of motor units (MUs) that is, at least partly, task-dependent. In order to compare MPF values calculated from RCs performed under different mechanical conditions (F, S and F+S), MPF-RMS(PSD) relationships have been established (RMS(PSD) being defined as the power spectrum density RMS). Both BBSH and BBLH exhibited initial MPF values higher in supination RC than in flexion RC. Because of plateau values reached at the same level of muscle activation whatever the task performed, the slope of the MPF-RMS(PSD) relationship was lower in S than in F. These results are in favour of MU recruitment that is, at least partly, different in F and in S conditions. Dual submaximal tasks seem to mix the activation of the F and S subpopulations of MUs as revealed by the spectral parameters obtained during F+S ramp contractions. This study could find some implication in the field of muscle rehabilitation or reinforcement.

Regulation of oocyte maturation in fish.

PubMed

Nagahama, Yoshitaka; Yamashita, Masakane

2008-06-01

A period of oocyte growth is followed by a process called oocyte maturation (the resumption of meiosis) which occurs prior to ovulation and is a prerequisite for successful fertilization. Our studies using fish models have revealed that oocyte maturation is a three-step induction process involving gonadotropin (LH), maturation-inducing hormone (MIH), and maturation-promoting factor (MPF). LH acts on the ovarian follicle layer to produce MIH (17alpha, 20beta-dihydroxy-4-pregnen-3-one, 17alpha, 20beta-DP, in most fishes). The interaction of ovarian thecal and granulosa cell layers (two-cell type model), is required for the synthesis of 17alpha,20beta-DP. The dramatic increase in the capacity of postvitellogenic follicles to produce 17alpha,20beta-DP in response to LH is correlated with decreases in P450c17 (P450c17-I) and P450 aromatase (oP450arom) mRNA and increases in the novel form of P450c17 (P450c17-II) and 20beta-hydroxysteroid dehydrogenase (20beta-HSD) mRNA. Transcription factors such as Ad4BP/SF-1, Foxl2, and CREB may be involved in the regulation of expression of these steroidogenic enzymes. A distinct family of G-protein-coupled membrane-bound MIH receptors has been shown to mediate non-genomic actions of 17alpha, 20beta-DP. The MIH signal induces the de novo synthesis of cyclin B from the stored mRNA, which activates a preexisting 35 kDa cdc2 kinase via phosphorylation of its threonine 161 by cyclin-dependent kinase activating kinase, thus producing the 34 kDa active cdc2 (active MPF). Upon egg activation, MPF is inactivated by degradation of cyclin B. This process is initiated by the 26S proteasome through the first cut in its NH(2) terminus at lysine 57.

Isometric quadriceps strength determines sailing performance and neuromuscular fatigue during an upwind sailing emulation.

PubMed

Bourgois, Jan G; Callewaert, Margot; Celie, Bert; De Clercq, Dirk; Boone, Jan

2016-01-01

This study investigates the physiological responses to upwind sailing on a laser emulation ergometer and analyses the components of the physical profile that determine the physiological responses related to sailing level. Ten male high-level laser sailors performed an upwind sailing test, incremental cycling test and quadriceps strength test. During the upwind sailing test, heart rate (HR), oxygen uptake, ventilation, respiratory exchange ratio, rating of perceived exertion (RPE) and lactate concentration were measured, combined with near-infrared spectroscopy (NIRS) and electromyography (EMG) registration of the M. Vastus lateralis. Repeated measures ANOVA showed for the cardio-respiratory, metabolic and muscles responses (mean power frequency [MPF], root mean square [RMS], deoxy[Hb+Mb]) during the upwind sailing test an initial significant increase followed by a stabilisation, despite a constant increase in RPE. Stepwise regression analysis showed that better sailing level was for 46.5% predicted by lower MPF decrease. Lower MPF decrease was for 57.8% predicted by a higher maximal isometric quadriceps strength. In conclusion, this study indicates that higher sailing level was mainly determined by a lower rate of neuromuscular fatigue during the upwind sailing test (as indicated by MPF decrease). Additionally, the level of neuromuscular fatigue was mainly determined by higher maximal isometric quadriceps strength stressing the importance of resistance training in the planning of training.

Muscle- and Mode-Specific Responses of the Forearm Flexors to Fatiguing, Concentric Muscle Actions

PubMed Central

Hill, Ethan; Housh, Terry; Smith, Cory; Schmidt, Richard; Johnson, Glen

2016-01-01

Background: Electromyographic (EMG) and mechanomyographic (MMG) studies of fatigue have generally utilized maximal isometric or dynamic muscle actions, but sport- and work-related activities involve predominately submaximal movements. Therefore, the purpose of the present investigation was to examine the torque, EMG, and MMG responses as a result of submaximal, concentric, isokinetic, forearm flexion muscle actions. Methods: Twelve men performed concentric peak torque (PT) and isometric PT trials before (pretest) and after (posttest) performing 50 submaximal (65% of concentric PT), concentric, isokinetic (60°·s−1), forearm flexion muscle actions. Surface EMG and MMG signals were simultaneously recorded from the biceps brachii and brachioradialis muscles. Results: The results of the present study indicated similar decreases during both the concentric PT and isometric PT measurements for torque, EMG mean power frequency (MPF), and MMG MPF following the fatiguing workbout, but no changes in EMG amplitude (AMP) or MMG AMP. Conclusions: These findings suggest that decreases in torque as a result of fatiguing, dynamic muscle actions may have been due to the effects of metabolic byproducts on excitation–contraction coupling as indicated by the decreases in EMG MPF and MMG MPF, but lack of changes in EMG AMP and MMG AMP from both the biceps brachii and brachioradialis muscles.

Polishing Step Purification of High-Strength Wastewaters by Nanofiltration and Reverse Osmosis

PubMed Central

Zhou, Jinxiang; Baker, Brian O.; Grimsley, Charles T.; Husson, Scott M.

2016-01-01

This article reports findings on the use of nanofiltration (NF) and reverse osmosis (RO) for secondary treatment of high-strength rendering facility wastewaters following an ultrafiltration step. These wastewaters present significant challenges to classical treatment technologies. Constant-pressure, direct-flow membrane filtration experiments were done to screen for flux and effluent water permeate quality of ten commercial NF and RO membranes. All membranes tested were effective in reducing total dissolved salts (TDS) and chemical oxygen demand (COD); however, only two membranes (Koch MPF-34 and Toray 70UB) gave sufficiently stable flux values to warrant longer term cross-flow filtration studies. Cross-flow flux measurements, scanning electron microscopy (SEM), X-ray dispersive spectroscopy (EDS), and attenuated total reflectance-Fourier-transform infrared spectroscopy (ATR-FTIR) indicated that both membranes were eventually fouled by organic and inorganic foulants; however, the Toray 70UB RO membrane yielded a capacity of 1600 L/m2 prior to cleaning. A preliminary economic analysis compared the estimated costs of energy and consumables for a dual-stage UF/RO membrane process and dissolved air floatation (DAF) and found membrane process costs could be less than about 40% of the current DAF process. PMID:26978407

The Effect of a Microprocessor Prosthetic Foot on Function and Quality of Life in Transtibial Amputees Who Are Limited Community Ambulators

DTIC Science & Technology

2017-09-01

parallel, randomized, controlled clinical trial designed to determine if a microprocessor controlled prosthetic foot (MPF), with greater range of...clinical trial designed to determine if a microprocessor controlled prosthetic foot (MPF), with greater range of motion and active power, will...Department of the Army position, policy or decision unless so designated by other documentation. CONTRACTING ORGANIZATION: University of Tennessee

Future Seabasing Technology Analysis: Logistics Systems

DTIC Science & Technology

2006-08-01

tech- nologies in the MPF(F) and, thus, the sea base will be through back- fit. The lack of backfit plans and engineering-level designs has created...the challenge of backfitting, there are no current plans for funding the backfitting of logistics technologies on the MPF(F) ships. In the absence of...Because of the overlap between the near-term technology develop- ment and the shipbuilding schedule, ONR and the Navy need to plan for incorporating

The influence of confounding factors on the relationship between muscle contraction level and MF and MPF values of EMG signal: a review.

PubMed

Roman-Liu, Danuta

2016-01-01

The purpose of this article is to gather results of studies on the relationship between median frequency (MF) and mean power frequency (MPF) and the level of muscle contraction, and to use those results to discuss the differences in the trends according to factors related to measurement technique and subject. Twenty-one studies with 63 cases for upper limb muscles and nine studies with 31 cases for lower limb muscles were analysed. Most results showed an increase in parameters with an increased level of muscle contraction, only some studies showed a decrease. The influence on parameters of the level of muscle contraction and factors such as subjects, type of contraction, muscle length and electrodes was analysed for each muscle. It was concluded that when analysing the influence of different factors on MF and MPF, because those factors interact they should be considered together, not separately.

Navy-Marine Corps Amphibious and Maritime Prepositioning Ship Programs: Background and Oversight Issues for Congress

DTIC Science & Technology

2007-06-12

up Northrop Grumman Ship Systems ( NGSS ). Table 2. FY2008-FY2013 Amphibious and MPF(F) Ship Procurement Plan (Ships fully funded in FY2006 shown for... Plan . . 13 Navy-Marine Corps Amphibious and Maritime Prepositioning Ship Programs: Background and Oversight Issues for Congress Introduction The...is whether to approve, modify, or reject the Navy’s plans for procuring amphibious and MPF(F) ships. Decisions that Congress makes on this CRS-2 1 The

Sustaining the Single Naval Battle: Enhancing USMC Expeditionary Logistics with the Addition of the Maritime Prepositioning Force (MPF) Auxiliary Dry Cargo / Ammunition Ships (T-AKES)

DTIC Science & Technology

2012-04-18

of Employment. Official Message. (CMC WASHINGTON DC PPO POE), DTG: 291447Z Mar 2010. 28 Military Sealift Command, Combat Logistics Force Webpage...Ammunition Ship (F-AKE) Concept of Employment. Official Message. (CMC WASHINGTON DC PPO POE), DTG: 291447Z Mar 2010. 28 30 Headquarters u.s. Marine Corps...Maritime Prepositioning Force (MPF) Auxiliary Dry Cargo/Ammunition Ship (I’-AKE) Concept of Employment. Official Message. (CMC WASHINGTON DC PPO POE

Best Practices in Shift Handover Communication: Mars Exploration Rover Surface Operations

NASA Astrophysics Data System (ADS)

Parke, Bonny; Mishkin, Andrew

2005-12-01

During its prime mission, Mars Exploration Rover (MER) had many shift handovers in its surface operations. Because of the increased rates of accidents and errors historically associated with shift handovers, MER Mission management paid close attention to shift handovers and, when possible, developed them in accordance with best handover practices.We review the most important of these best practices, and include a generic "Checklist for Effective Handovers" to aid in the development of handovers.We present charts that depict structured information transfer across shifts. These charts show personnel schedules, meetings attended, handovers, and hand-offs on both the MER and on the earlier Mars Pathfinder Mission (MPF). It is apparent from these charts that although the MER Mission had a much larger number of surface operations personnel than MPF (approximately 300 vs. 178), and had three shifts instead of two, that it used many of the successful MPF communication strategies. Charts such as these can be helpful to those designing complicated and unique mission surface operations.

The influence of confounding factors on the relationship between muscle contraction level and MF and MPF values of EMG signal: a review

PubMed Central

Roman-Liu, Danuta

2016-01-01

The purpose of this article is to gather results of studies on the relationship between median frequency (MF) and mean power frequency (MPF) and the level of muscle contraction, and to use those results to discuss the differences in the trends according to factors related to measurement technique and subject. Twenty-one studies with 63 cases for upper limb muscles and nine studies with 31 cases for lower limb muscles were analysed. Most results showed an increase in parameters with an increased level of muscle contraction, only some studies showed a decrease. The influence on parameters of the level of muscle contraction and factors such as subjects, type of contraction, muscle length and electrodes was analysed for each muscle. It was concluded that when analysing the influence of different factors on MF and MPF, because those factors interact they should be considered together, not separately. PMID:26654476

Effects of Litter Manipulation on Litter Decomposition in a Successional Gradients of Tropical Forests in Southern China

PubMed Central

Chen, Hao; Gurmesa, Geshere A.; Liu, Lei; Zhang, Tao; Fu, Shenglei; Liu, Zhanfeng; Dong, Shaofeng; Ma, Chuan; Mo, Jiangming

2014-01-01

Global changes such as increasing CO2, rising temperature, and land-use change are likely to drive shifts in litter inputs to forest floors, but the effects of such changes on litter decomposition remain largely unknown. We initiated a litter manipulation experiment to test the response of litter decomposition to litter removal/addition in three successional forests in southern China, namely masson pine forest (MPF), mixed coniferous and broadleaved forest (MF) and monsoon evergreen broadleaved forest (MEBF). Results showed that litter removal decreased litter decomposition rates by 27%, 10% and 8% and litter addition increased litter decomposition rates by 55%, 36% and 14% in MEBF, MF and MPF, respectively. The magnitudes of changes in litter decomposition were more significant in MEBF forest and less significant in MF, but not significant in MPF. Our results suggest that change in litter quantity can affect litter decomposition, and this impact may become stronger with forest succession in tropical forest ecosystem. PMID:24901698

(abstract) Scaling Nominal Solar Cell Impedances for Array Design

NASA Technical Reports Server (NTRS)

Mueller, Robert L; Wallace, Matthew T.; Iles, Peter

1994-01-01

This paper discusses a task the objective of which is to characterize solar cell array AC impedance and develop scaling rules for impedance characterization of large arrays by testing single solar cells and small arrays. This effort is aimed at formulating a methodology for estimating the AC impedance of the Mars Pathfinder (MPF) cruise and lander solar arrays based upon testing single cells and small solar cell arrays and to create a basis for design of a single shunt limiter for MPF power control of flight solar arrays having very different inpedances.

A TALEN-Exon Skipping Design for a Bethlem Myopathy Model in Zebrafish.

PubMed

Radev, Zlatko; Hermel, Jean-Michel; Elipot, Yannick; Bretaud, Sandrine; Arnould, Sylvain; Duchateau, Philippe; Ruggiero, Florence; Joly, Jean-Stéphane; Sohm, Frédéric

2015-01-01

Presently, human collagen VI-related diseases such as Ullrich congenital muscular dystrophy (UCMD) and Bethlem myopathy (BM) remain incurable, emphasizing the need to unravel their etiology and improve their treatments. In UCMD, symptom onset occurs early, and both diseases aggravate with ageing. In zebrafish fry, morpholinos reproduced early UCMD and BM symptoms but did not allow to study the late phenotype. Here, we produced the first zebrafish line with the human mutation frequently found in collagen VI-related disorders such as UCMD and BM. We used a transcription activator-like effector nuclease (TALEN) to design the col6a1ama605003-line with a mutation within an essential splice donor site, in intron 14 of the col6a1 gene, which provoke an in-frame skipping of exon 14 in the processed mRNA. This mutation at a splice donor site is the first example of a template-independent modification of splicing induced in zebrafish using a targetable nuclease. This technique is readily expandable to other organisms and can be instrumental in other disease studies. Histological and ultrastructural analyzes of homozygous and heterozygous mutant fry and 3 months post-fertilization (mpf) fish revealed co-dominantly inherited abnormal myofibers with disorganized myofibrils, enlarged sarcoplasmic reticulum, altered mitochondria and misaligned sarcomeres. Locomotion analyzes showed hypoxia-response behavior in 9 mpf col6a1 mutant unseen in 3 mpf fish. These symptoms worsened with ageing as described in patients with collagen VI deficiency. Thus, the col6a1ama605003-line is the first adult zebrafish model of collagen VI-related diseases; it will be instrumental both for basic research and drug discovery assays focusing on this type of disorders.

A TALEN-Exon Skipping Design for a Bethlem Myopathy Model in Zebrafish

PubMed Central

Elipot, Yannick; Bretaud, Sandrine; Arnould, Sylvain; Duchateau, Philippe; Ruggiero, Florence; Joly, Jean-Stéphane; Sohm, Frédéric

2015-01-01

Presently, human collagen VI-related diseases such as Ullrich congenital muscular dystrophy (UCMD) and Bethlem myopathy (BM) remain incurable, emphasizing the need to unravel their etiology and improve their treatments. In UCMD, symptom onset occurs early, and both diseases aggravate with ageing. In zebrafish fry, morpholinos reproduced early UCMD and BM symptoms but did not allow to study the late phenotype. Here, we produced the first zebrafish line with the human mutation frequently found in collagen VI-related disorders such as UCMD and BM. We used a transcription activator-like effector nuclease (TALEN) to design the col6a1ama605003-line with a mutation within an essential splice donor site, in intron 14 of the col6a1 gene, which provoke an in-frame skipping of exon 14 in the processed mRNA. This mutation at a splice donor site is the first example of a template-independent modification of splicing induced in zebrafish using a targetable nuclease. This technique is readily expandable to other organisms and can be instrumental in other disease studies. Histological and ultrastructural analyzes of homozygous and heterozygous mutant fry and 3 months post-fertilization (mpf) fish revealed co-dominantly inherited abnormal myofibers with disorganized myofibrils, enlarged sarcoplasmic reticulum, altered mitochondria and misaligned sarcomeres. Locomotion analyzes showed hypoxia-response behavior in 9 mpf col6a1 mutant unseen in 3 mpf fish. These symptoms worsened with ageing as described in patients with collagen VI deficiency. Thus, the col6a1ama605003-line is the first adult zebrafish model of collagen VI-related diseases; it will be instrumental both for basic research and drug discovery assays focusing on this type of disorders. PMID:26221953

Mars Exploration Rover Entry, Descent, and Landing: A Thermal Perspective

NASA Technical Reports Server (NTRS)

Tsuyuki, Glenn T.; Sunada, Eric T.; Novak, Keith S.; Kinsella, Gary M.; Phillip, Charles J.

2005-01-01

Perhaps the most challenging mission phase for the Mars Exploration Rovers was the Entry, Descent, and Landing (EDL). During this phase, the entry vehicle attached to its cruise stage was transformed into a stowed tetrahedral Lander that was surrounded by inflated airbags through a series of complex events. There was only one opportunity to successfully execute an automated command sequence without any possible ground intervention. The success of EDL was reliant upon the system thermal design: 1) to thermally condition EDL hardware from cruise storage temperatures to operating temperature ranges; 2) to maintain the Rover electronics within operating temperature ranges without the benefit of the cruise single phase cooling loop, which had been evacuated in preparation for EDL; and 3) to maintain the cruise stage propulsion components for the critical turn to entry attitude. Since the EDL architecture was inherited from Mars Pathfinder (MPF), the initial EDL thermal design would be inherited from MPF. However, hardware and implementation differences from MPF ultimately changed the MPF inheritance approach for the EDL thermal design. With the lack of full inheritance, the verification and validation of the EDL thermal design took on increased significance. This paper will summarize the verification and validation approach for the EDL thermal design along with applicable system level thermal testing results as well as appropriate thermal analyses. In addition, the lessons learned during the system-level testing will be discussed. Finally, the in-flight EDL experiences of both MER-A and -B missions (Spirit and Opportunity, respectively) will be presented, demonstrated how lessons learned from Spirit were applied to Opportunity.

Inter-individual variability in the patterns of responses for electromyography and mechanomyography during cycle ergometry using an RPE-clamp model.

PubMed

Cochrane-Snyman, Kristen C; Housh, Terry J; Smith, Cory M; Hill, Ethan C; Jenkins, Nathaniel D M; Schmidt, Richard J; Johnson, Glen O

2016-09-01

To examine inter-individual variability versus composite models for the patterns of responses for electromyography (EMG) and mechanomyography (MMG) versus time relationships during moderate and heavy cycle ergometry using a rating of perceived exertion (RPE) clamp model. EMG amplitude (amplitude root-mean-square, RMS), EMG mean power frequency (MPF), MMG-RMS, and MMG-MPF were collected during two, 60-min rides at a moderate (RPE at the gas exchange threshold; RPEGET) and heavy (RPE at 15 % above the GET; RPEGET+15 %) intensity when RPE was held constant (clamped). Composite (mean) and individual responses for EMG and MMG parameters were compared during each 60-min ride. There was great inter-individual variability for each EMG and MMG parameters at RPEGET and RPEGET+15 %. Composite models showed decreases in EMG-RMS (r (2) = -0.92 and R (2) = 0.96), increases in EMG-MPF (R (2) = 0.90), increases in MMG-RMS (r (2) = 0.81 and 0.55), and either no change or a decrease (r (2) = 0.34) in MMG-MPF at RPEGET and RPEGET+15 %, respectively. The results of the present study indicated that there were differences between composite and individual patterns of responses for EMG and MMG parameters during moderate and heavy cycle ergometry at a constant RPE. Thus, composite models did not represent the unique muscle activation strategies exhibited by individual responses when cycling in the moderate and heavy intensity domains when using an RPE-clamp model.

The effects of accumulated muscle fatigue on the mechanomyographic waveform: implications for injury prediction.

PubMed

Tosovic, D; Than, C; Brown, J M M

2016-08-01

Muscle fatigue has been identified as a risk factor for spontaneous muscle injuries in sport. However, few studies have investigated the accumulated effects of muscle fatigue on human muscle contractile properties. This study aimed to determine whether repeated bouts of exercise inducing acute fatigue leads to longer-term fatigue-related changes in muscle contractile properties. Maximum voluntary contraction (MVC), electromyographic (EMG) and mechanomyographic (MMG) measures were recorded in the biceps brachii of 11 participants for 13 days, before and after a maximally fatiguing exercise protocol. The exercise protocol involved participants repetitively lifting a weight (concentric contractions only) equal to 40 % MVC, until failure. A significant (p < 0.05) acute pre- to post-exercise decline of biceps brachii MVC and median power frequency (MPF) was observed each day, whilst no difference existed between pre-exercise MVC or MPF values on subsequent days (days 2-13). However, decreases in number of lift repetitions and in pre-exercise MMG values of muscle belly displacement, contraction velocity and half-relaxation velocity were observed through to day 13. Whilst MVC and MPF measures resolved by the following day's test session, MMG measures indicated an ongoing decrement in muscle performance through days 2-13 consistent with the decline in lift repetitions observed. These results suggest that MMG may be more sensitive in detecting accumulated muscle fatigue than the 'gold standard' measures of MVC/MPF. Considering that muscle fatigue leads to injury, the on-going monitoring of MMG derived contractile properties of muscles in athletes may aid in the prediction of fatigued-induced muscle injury.

Gold nanoparticles modified electrode via simple electrografting of in situ generated mercaptophenyl diazonium cations for development of DNA electrochemical biosensor.

PubMed

Li, Feng; Feng, Yan; Dong, Pingjun; Yang, Limin; Tang, Bo

2011-01-15

A novel protocol for development of DNA electrochemical biosensor based on gold nanoparticles (AuNPs) modified glassy carbon electrode (GCE) was proposed, which was carried out by the self-assembly of AuNPs on the mercaptophenyl film (MPF) via simple electrografting of in situ generated mercaptophenyl diazonium cations. The resulting MPF was covalently immobilized on GCE surface via C-C bond with high stability, which was desirable in fabrication of excellent performance biosensors. Probe DNA was self-assembled on AuNPs through the well-known Au-thiol binding. The recognition of fabricated DNA electrochemical biosensor toward complementary single-stranded DNA was determined by differential pulse voltammetry with the use of Co(phen)(3)(3+) as the electrochemical indicator. Taking advantage of amplification effects of AuNPs and stability of MPF, the developed biosensor could detect target DNA with the detection limit of 7.2×10(-11) M, which also exhibits good selectivity, stability and regeneration ability for DNA detection. Copyright © 2010 Elsevier B.V. All rights reserved.

The influence of muscle fiber type composition on the patterns of responses for electromyographic and mechanomyographic amplitude and mean power frequency during a fatiguing submaximal isometric muscle action.

PubMed

Beck, T W; Housh, T J; Fry, A C; Cramer, J T; Weir, J P; Schilling, B K; Falvo, M J; Moore, C A

2007-07-01

The purpose of this investigation was to examine the influence of muscle fiber type composition on the patterns of responses for electromyographic (EMG) and mechanomyographic (MMG) amplitude and mean power frequency (MPF) during a fatiguing submaximal isometric muscle action. Five resistance-trained (mean +/- SD age = 23.2 +/- 3.7 yrs) and five aerobically-trained (mean +/- SD age = 32.6 +/- 5.2 yrs) men volunteered to perform a fatiguing, 30-sec submaximal isometric muscle action of the leg extensors at 50% of the maximum voluntary contraction (MVC). Muscle biopsies from the vastus lateralis revealed that the myosin heavy chain (MHC) composition for the resistance-trained subjects was 59.0 +/- 4.2% Type IIa, 0.1 +/- 0.1% Type IIx, and 40.9 +/- 4.3% Type I. The aerobically-trained subjects had 27.4 +/- 7.8% Type IIa, 0.0 +/- 0.0% Type IIx, and 72.6 +/- 7.8% Type I MHC. The patterns of responses and mean values for absolute and normalized EMG amplitude and MPF during the fatiguing muscle action were similar for the resistance-trained and aerobically-trained subjects. The resistance-trained subjects demonstrated relatively stable levels for absolute and normalized MMG amplitude and MPF across time, but the aerobically-trained subjects showed increases in MMG amplitude and decreases in MMG MPE The absolute MMG amplitude and MPF values for the resistance-trained subjects were also greater than those for the aerobi-cally-trained subjects. These findings suggested that unlike surface EMG, MMG may be a useful noninvasive technique for examining fatigue-related differences in muscle fiber type composition.

Zebrafish as a possible bioindicator of organic pollutants with effects on reproduction in drinking waters.

PubMed

Martínez-Sales, M; García-Ximénez, F; Espinós, F J

2015-07-01

Organic contaminants can be detected at low concentrations in drinking water, raising concerns for human health, particularly in reproduction. In this respect, we attempted to use the zebrafish as a bioindicator to detect the possible presence of these substances in drinking water, aiming to define the most relevant parameters to detect these substances, which particularly affect the development and reproduction of zebrafish. To this end, batches of 30 embryos with the chorion intact were cultured in drinking waters from different sources, throughout their full life-cycle up to 5 months, in 20 L tanks. Six replicates were performed in all water groups, with a total of 24 aquariums. Two generations (F0 and F1) were studied and the following parameters were tested: in the F0 generation, survival and abnormality rates evaluated at 5 dpf (days post-fertilization) and at 5 mpf (months post-fertilization), the onset of spawning and the fertility rate from 3 mpf to 5 mpf, and the sex ratio and underdeveloped specimens at 5 mpf. Furthermore, in the F0 offspring (F1), survival and abnormality rates were evaluated at 5 dpf and the hatching rate at 72 hpf. These results revealed that the hatching rate is the most sensitive parameter to distinguish different levels of effects between waters during the early life stages, whereas the rate of underdeveloped specimens is more suitable at later life stages. Regarding adult reproduction, fertility rate was the most sensitive parameter. The possible reversibility or accumulative nature of such effects will be studied in future work. Copyright © 2015. Published by Elsevier B.V.

Optimization of D-lactic acid production using unutilized biomass as substrates by multiple parallel fermentation.

PubMed

Mufidah, Elya; Wakayama, Mamoru

2016-12-01

This study investigated the optimization of D-lactic acid production from unutilized biomass, specifically banana peel and corncob by multiple parallel fermentation (MPF) with Leuconostoc mesenteroides and Aspergillus awamori. The factors involved in MPF that were assessed in this study comprised banana peel and corncob, KH 2 PO 4 , Tween 80, MgSO 4 ·7H 2 O, NaCl, yeast extract, and diammonium hydrogen citrate to identify the optimal concentration for D-lactic acid production. Optimization of these component factors was performed using the Taguchi method with an L8 orthogonal array. The optimal concentrations for the effectiveness of MPF using biomass substrates were as follows: (1) banana peel, D-lactic acid production was 31.8 g/L in medium containing 15 % carbon source, 0.5 % KH 2 PO 4 , 0.1 % Tween 80, 0.05 % MgSO 4 ·7H 2 O, 0.05 % NaCl, 1.5 % yeast extract, and 0.2 % diammonium hydrogen citrate. (2) corncob, D-lactic acid production was 38.3 g/L in medium containing 15 % of a carbon source, 0.5 % KH 2 PO 4 , 0.1 % Tween 80, 0.05 % MgSO 4 ·7H 2 O, 0.1 % NaCl, 1.0 % yeast extract, and 0.4 % diammonium hydrogen citrate. Thus, both banana peel and corncob are unutilized potential resources for D-lactic acid production. These results indicate that MPF using L. mesenteroides and A. awamori could constitute part of a potential industrial application of the currently unutilized banana peel and corncob biomass for D-lactic acid production.

Effect of vibration during fatiguing resistance exercise on subsequent muscle activity during maximal voluntary isometric contractions.

PubMed

McBride, Jeffrey M; Porcari, John P; Scheunke, Mark D

2004-11-01

This investigation was designed to determine if vibration during fatiguing resistance exercise would alter associated patterns of muscle activity. A cross-over design was employed with 8 subjects completing a resistance exercise bout once with a vibrating dumbbell (V) (44 Hz, 3 mm displacement) and once without vibration (NV). For both exercise bouts, 10 sets were performed with a load that induced concentric muscle failure during the 10th repetition. The appropriate load for each set was determined during a pretest. Each testing session was separated by 1 week. Electromyography (EMG) was obtained from the biceps brachii muscle at 12 different time points during a maximum voluntary contraction (MVC) at a 170 degrees elbow angle after each set of the dumbbell exercise. The time points were as follows: pre (5 minutes before the resistance exercise bout), T1-T10 (immediately following each set of resistance exercise), and post (15 minutes after the resistance exercise bout). EMG was analyzed for median power frequency (MPF) and maximum (mEMG). NV resulted in a significant decrease in MPF at T1-T4 (p < or 0.05) and a significant increase in mEMG at T2 during the MVC. V had an overall trend of lower mEMG in comparison to NV. The mEMG and MPF values associated with NV were similar to previously reported investigations. The lower mEMG values and the higher MPF of V in comparison to NV are undocumented. The EMG patterns observed with vibration may indicate a more efficient and effective recruitment of high threshold motor units during fatiguing contractions. This may indicate the usage of vibration with resistance exercise as an effective tool for strength training athletes.

Ultra-wideband microwave photonic filter with a high Q-factor using a semiconductor optical amplifier.

PubMed

Chen, Han

2017-04-01

An ultra-wideband microwave photonic filter (MPF) with a high quality (Q)-factor based on the birefringence effects in a semiconductor optical amplifier (SOA) is presented, and the theoretical fundamentals of the design are explained. The proposed MPF along orthogonal polarization in an active loop operates at up to a Ku-band and provides a tunable free spectral range from 15.44 to 19.44 GHz by controlling the SOA injection current. A prototype of the equivalent second-order infinite impulse response filter with a Q-factor over 6300 and a rejection ration exceeding 41 dB is experimentally demonstrated.

Three-Dimensional Biomechanical Analysis of Rearfoot and Forefoot Running.

PubMed

Knorz, Sebastian; Kluge, Felix; Gelse, Kolja; Schulz-Drost, Stefan; Hotfiel, Thilo; Lochmann, Matthias; Eskofier, Björn; Krinner, Sebastian

2017-07-01

In the running community, a forefoot strike (FFS) pattern is increasingly preferred compared with a rearfoot strike (RFS) pattern. However, it has not been fully understood which strike pattern may better reduce adverse joint forces within the different joints of the lower extremity. To analyze the 3-dimensional (3D) stress pattern in the ankle, knee, and hip joint in runners with either a FFS or RFS pattern. Descriptive laboratory study. In 22 runners (11 habitual rearfoot strikers, 11 habitual forefoot strikers), RFS and FFS patterns were compared at 3.0 m/s (6.7 mph) on a treadmill with integrated force plates and a 3D motion capture analysis system. This combined analysis allowed characterization of the 3D biomechanical forces differentiated for the ankle, knee, and hip joint. The maximum peak force (MPF) and maximum loading rate (LR) were determined in their 3 ordinal components: vertical, anterior-posterior (AP), and medial-lateral (ML). For both strike patterns, the vertical components of the MPF and LR were significantly greater than their AP or ML components. In the vertical axis, FFS was generally associated with a greater MPF but significantly lower LR in all 3 joints. The AP components of MPF and LR were significantly lower for FFS in the knee joint but significantly greater in the ankle and hip joints. The ML components of MPF and LR tended to be greater for FFS but mostly did not reach a level of significance. FFS and RFS were associated with different 3D stress patterns in the ankle, knee, and hip joint, although there was no global advantage of one strike pattern over the other. The multimodal individual assessment for the different anatomic regions demonstrated that FFS seems favorable for patients with unstable knee joints in the AP axis and RFS may be recommended for runners with unstable ankle joints. Different strike patterns show different 3D stress in joints of the lower extremity. Due to either rehabilitation after injuries or training in running sports, rearfoot or forefoot running should be preferred to prevent further damage or injuries caused by inadequate biomechanical load. Runners with a history of knee joint injuries may benefit from FFS whereas RFS may be favorable for runners with a history of ankle joint injuries.

Three-Dimensional Biomechanical Analysis of Rearfoot and Forefoot Running

PubMed Central

Knorz, Sebastian; Kluge, Felix; Gelse, Kolja; Schulz-Drost, Stefan; Hotfiel, Thilo; Lochmann, Matthias; Eskofier, Björn; Krinner, Sebastian

2017-01-01

Background: In the running community, a forefoot strike (FFS) pattern is increasingly preferred compared with a rearfoot strike (RFS) pattern. However, it has not been fully understood which strike pattern may better reduce adverse joint forces within the different joints of the lower extremity. Purpose: To analyze the 3-dimensional (3D) stress pattern in the ankle, knee, and hip joint in runners with either a FFS or RFS pattern. Study Design: Descriptive laboratory study. Methods: In 22 runners (11 habitual rearfoot strikers, 11 habitual forefoot strikers), RFS and FFS patterns were compared at 3.0 m/s (6.7 mph) on a treadmill with integrated force plates and a 3D motion capture analysis system. This combined analysis allowed characterization of the 3D biomechanical forces differentiated for the ankle, knee, and hip joint. The maximum peak force (MPF) and maximum loading rate (LR) were determined in their 3 ordinal components: vertical, anterior-posterior (AP), and medial-lateral (ML). Results: For both strike patterns, the vertical components of the MPF and LR were significantly greater than their AP or ML components. In the vertical axis, FFS was generally associated with a greater MPF but significantly lower LR in all 3 joints. The AP components of MPF and LR were significantly lower for FFS in the knee joint but significantly greater in the ankle and hip joints. The ML components of MPF and LR tended to be greater for FFS but mostly did not reach a level of significance. Conclusion: FFS and RFS were associated with different 3D stress patterns in the ankle, knee, and hip joint, although there was no global advantage of one strike pattern over the other. The multimodal individual assessment for the different anatomic regions demonstrated that FFS seems favorable for patients with unstable knee joints in the AP axis and RFS may be recommended for runners with unstable ankle joints. Clinical Relevance: Different strike patterns show different 3D stress in joints of the lower extremity. Due to either rehabilitation after injuries or training in running sports, rearfoot or forefoot running should be preferred to prevent further damage or injuries caused by inadequate biomechanical load. Runners with a history of knee joint injuries may benefit from FFS whereas RFS may be favorable for runners with a history of ankle joint injuries. PMID:28812039

Plant hormones including ethylene are recruited in calyx inflation in Solanaceous plants.

PubMed

Khan, Muhammad Ramzan; Hu, Jinyong; He, Chaoying

2012-07-01

Plant hormones direct many processes of floral and post-floral morphogenesis in Angiosperms. However, their role in shaping floral morphological novelties, such as inflated calyx syndrome (ICS) exhibited by a few genera of the Solanaceae, remains unknown. In Withania and Physalis, sepals resume growth after pollination and encapsulate the mature fruit to form a balloon-like structure, i.e. ICS. The epidermal cells of calyx show enlargement and lobation post-fertilization. Application of hormones to depistillated flower buds of Withania revealed that cytokinins and gibberellins mimic fertilization signals. The ICS development is a synchronous step with fruit development; both processes are under the control of more or less the same set of hormones, including cytokinins and gibberellic acids. Interestingly, inhibition of ethylene in the system is sufficient to yield inflated calyx in Withania. In contrast, Tubocapsicum, a closely related species and an evolutionary natural loss mutant of ICS - showed no response to applied hormones, and ethylene led to inflation of the receptacle indirectly. In addition to hormones, the expression of an MPF2-like MADS-box transcription factor in sepals is essential for ICS formation. Nevertheless, the interactions between MPF2-like genes and hormones are barely detectable at the transcript level. Our data provide insight into the role of hormones in generating floral morphological diversity during evolution. Copyright © 2012 Elsevier GmbH. All rights reserved.

Induction of a Mitosis Delay and Cell Lysis by High-Level Secretion of Mouse α-Amylase from Saccharomyces cerevisiae

PubMed Central

Wang, Bi-Dar; Kuo, Tsong-Teh

2001-01-01

Some foreign proteins are produced in yeast in a cell cycle-dependent manner, but the cause of the cell cycle dependency is unknown. In this study, we found that Saccharomyces cerevisiae cells secreting high levels of mouse α-amylase have elongated buds and are delayed in cell cycle completion in mitosis. The delayed cell mitosis suggests that critical events during exit from mitosis might be disturbed. We found that the activities of PP2A (protein phosphatase 2A) and MPF (maturation-promoting factor) were reduced in α-amylase-oversecreting cells and that these cells showed a reduced level of assembly checkpoint protein Cdc55, compared to the accumulation in wild-type cells. MPF inactivation is due to inhibitory phosphorylation on Cdc28, as a cdc28 mutant which lacks an inhibitory phosphorylation site on Cdc28 prevents MPF inactivation and prevents the defective bud morphology induced by overproduction of α-amylase. Our data also suggest that high levels of α-amylase may downregulate PPH22, leading to cell lysis. In conclusion, overproduction of heterologous α-amylase in S. cerevisiae results in a negative regulation of PP2A, which causes mitotic delay and leads to cell lysis. PMID:11472949

Wind Tunnel Testing of Various Disk-Gap-Band Parachutes

NASA Technical Reports Server (NTRS)

Cruz, Juan R.; Mineck, Raymond E.; Keller, Donald F.; Bobskill, Maria V.

2003-01-01

Two Disk-Gap-Band model parachute designs were tested in the NASA Langley Transonic Dynamics Tunnel. The purposes of these tests were to determine the drag and static stability coefficients of these two model parachutes at various subsonic Mach numbers in support of the Mars Exploration Rover mission. The two model parachute designs were designated 1.6 Viking and MPF. These model parachute designs were chosen to investigate the tradeoff between drag and static stability. Each of the parachute designs was tested with models fabricated from MIL-C-7020 Type III or F-111 fabric. The reason for testing model parachutes fabricated with different fabrics was to evaluate the effect of fabric permeability on the drag and static stability coefficients. Several improvements over the Viking-era wind tunnel tests were implemented in the testing procedures and data analyses. Among these improvements were corrections for test fixture drag interference and blockage effects, and use of an improved test fixture for measuring static stability coefficients. The 1.6 Viking model parachutes had drag coefficients from 0.440 to 0.539, while the MPF model parachutes had drag coefficients from 0.363 to 0.428. The 1.6 Viking model parachutes had drag coefficients 18 to 22 percent higher than the MPF model parachute for equivalent fabric materials and test conditions. Model parachutes of the same design tested at the same conditions had drag coefficients approximately 11 to 15 percent higher when manufactured from F-111 fabric as compared to those fabricated from MIL-C-7020 Type III fabric. The lower fabric permeability of the F-111 fabric was the source of this difference. The MPF model parachutes had smaller absolute statically stable trim angles of attack as compared to the 1.6 Viking model parachutes for equivalent fabric materials and test conditions. This was attributed to the MPF model parachutes larger band height to nominal diameter ratio. For both designs, model parachutes fabricated from F-111 fabric had significantly greater statically stable absolute trim angles of attack at equivalent test conditions as compared to those fabricated from MILC-7020 Type III fabric. This reduction in static stability exhibited by model parachutes fabricated from F-111 fabric was attributed to the lower permeability of the F-111 fabric. The drag and static stability coefficient results were interpolated to obtain their values at Mars flight conditions using total porosity as the interpolating parameter.

Determination of chemical composition of soils and rocks at the MER landing sites Gusev crater and Meridiani Planum using the APXS

NASA Astrophysics Data System (ADS)

Brueckner, J.

2004-05-01

The new Alpha Particle X-Ray Spectrometer (APXS) is a small, light-weight instrument to obtain x-ray spectra from Martian surface samples. The sensor head contains a high-resolution x-ray detector that is surrounded by a circle of radioactive Cm-244 sources. Alpha and x-ray radiation emitted by the sources is used to induce x-ray excitation in the sample. Elements from sodium to zinc (increasing by atomic weight) are detected and their concentrations determined. The APXS is mounted on each Instrument Deployment Device (IDD) of the two Mars Exploration Rovers (MER) Spirit and Opportunity. Rover Spirit landed in the large Gusev crater that seems to have been altered by water activities in the past based on evidence of orbital images. Rover Opportunity landed in a very small crater of the Meridiani Planum, where the mineral hematite that points to water-related processes is expected to be found. Inside the little crater, a light-colored outcrop is exposed that shows widespread fine layering. The first APXS high-resolution x-ray spectrum of a Gusev soil indicated many similarities to the composition of the Mars Pathfinder (MPF) and Viking soils. However, differences are also noticeable: Low-Z elements are somewhat higher compared to MPF soils, while high-Z elements are depleted, notably Ti. Potassium in the soils reflects the K concentration of the local rocks at the different landing sites pointing toward a local contribution to the soil's composition. The Rock Abrasion Tool was used to grind the first rock on Mars at Gusev: Adirondack's undisturbed and ground surface was measured by the APXS. The composition of its fresh surface is different from the MPF soilfree rock, noticeably in Mg and Al, and clearly exhibits a basaltic nature related to the composition of basaltic shergottites. The first rock at the Meridiani crater outcrop (dubbed Robert-E) exhibited a very high sulfur concentration, more than a factor of 15 compared to rock Adirondack, indicating it is doubtful that this outcrop is from igneous activity. Camera based observations of the layering of rock Robert-E and its chemical composition are pointing to a sedimentary process where sulfate played a significant role in the cementation of the outcrop.

Effects of voluntary and automatic control of center of pressure sway during quiet standing.

PubMed

Ueta, Kozo; Okada, Yohei; Nakano, Hideki; Osumi, Michihiro; Morioka, Shu

2015-01-01

The authors investigated the effects of voluntary and automatic control on the spatial variables (envelope area, maximal amplitude, and root mean square [RMS]) of center of pressure (COP) displacement during quiet standing and identified differences in their postural control strategies (mean velocity [MV], mean power frequency [MPF], and power density). COP data were recorded under relaxed (experimental control), still (voluntary control), and dual (automatic control) conditions. RMS was significantly lower in the still and dual conditions than in the relaxed condition. MV, MPF, and power density were significantly higher in the still condition than in the dual condition. These results indicate that both voluntary and automatic control decrease the spatial variables of COP displacement; however, their postural control strategies are different.

General geology and geomorphology of the Mars Pathfinder landing site

USGS Publications Warehouse

Ward, A.W.; Gaddis, L.R.; Kirk, R.L.; Soderblom, L.A.; Tanaka, K.L.; Golombek, M.P.; Parker, T.J.; Greeley, Ronald; Kuzmin, R.O.

1999-01-01

The Mars Pathfinder (MPF) spacecraft landed on relatively young (late Hesperian-early Amazonian; 3.1-0.7 Ga) plains in Chryse Planitia near the mouth of Ares Vallis. Images returned from the spacecraft reveal a complex landscape of ridges and troughs, large hills and crater rims, rocks and boulders of various sizes and shapes, and surficial deposits, indicating a complex, multistage geologic history of the landing site. After the deposition of one or more bedrock units, depositional and erosional fluvial processes shaped much of the present landscape. Multiple erosional events are inferred on the basis of observations of numerous channels, different orientations of many streamlined tails from their associated knobs and hills, and superposition of lineations and streamlines. Medium- and small-scale features, interpreted to be related to late-stage drainage of floodwaters, are recognized in several areas at the landing site. Streamlined knobs and hills seen in Viking orbiter images support this inference, as they seem to be complex forms, partly erosional and partly depositional, and may also indicate a series of scouring and depositional events that, in some cases, further eroded or partially buried these landforms. Although features such as these are cited as evidence for catastrophic flooding at Ares Vallis, some of these features may also be ascribed to alternative primary or secondary depositional processes, such as glacial or mass-wasting processes. Close inspection of the landing site reveals rocks that are interpreted to be volcanic in origin and others that may be conglomeratic. If such sedimentary rocks are confirmed, fluvial processes have had a greater significance on Mars than previously thought. For the last several hundred million to few billion years, eolian processes have been dominant. Dunes and dune-like features, ventifacts, and deflation and exhumation features around several rocks probably are the most recent landforms. The relatively pristine nature of the overall landscape at the MPF site suggests weathering and erosion processes on Mars are exceptionally slow.

32 CFR 179.6 - Procedures.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Pathway Factor (MPF), which indicates environmental migration pathways, and contributes a level of H, M, or L based on Evident, Potential or Confined pathways, respectively. (See appendix A, table 21.) (3...

32 CFR 179.6 - Procedures.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Pathway Factor (MPF), which indicates environmental migration pathways, and contributes a level of H, M, or L based on Evident, Potential or Confined pathways, respectively. (See appendix A, table 21.) (3...

Effect of insulin on spontaneous and progesterone-induced GVBD on Bufo arenarum denuded oocytes.

PubMed

Sánchez Toranzo, G; Bonilla, F; Zelarayán, L; Oterino, J; Bühler, M I

2004-08-01

Progesterone is considered as the physiological steroid hormone that triggers meiosis reinitiation in amphibian oocytes. Nevertheless, isolated oocytes can be induced to undergo germinal vesicle breakdown (GVBD) in a saline medium by means of treatment with various hormones or inducing agents such as other steroid hormones, insulin or an insulin-like growth factor. It has been demonstrated that Bufo arenarum oocytes obtained during the reproductive period (spring-summer) resume meiosis with no need of an exogenous hormonal stimulus if deprived of their enveloping follicle cells, a phenomenon called spontaneous maturation. This study was undertaken to evaluate the participation of the purine and phosphoinositide pathway in the insulin-induced maturation of oocytes competent and incompetent to mature spontaneously, as well as to determine whether the activation of the maturation promoting factor (MPF) involved the activation of cdc25 phosphatase in Bufo arenarum denuded oocytes. Our results indicate that insulin was able to induce GBVD in oocytes incompetent to mature spontaneously and to enhance spontaneous and progesterone-induced maturation. In addition, high intracellular levels of purines such as cAMP or guanosine can reversibly inhibit the progesterone and insulin-induced maturation process in Bufo arenarum as well as spontaneous maturation. Assays of the inhibition of phosphatidylinositol-4,5-bisphosphate (PIP2) hydrolysis and its turnover by neomycin and lithium chloride respectively exhibited a different response in insulin- or progesterone-treated oocytes, suggesting that phosphoinositide turnover or hydrolysis of PIP2 is involved in progesterone- but not in insulin-induced maturation. In addition, the inhibitory effect of vanadate suggests that an inactive pre-maturation promoting factor (pre-MPF), activated by dephosphorylation of Thr-14 and Tyr-15 on p34cdc2, is present in Bufo arenarum full-grown oocytes; this step would be common to both spontaneous and hormone-induced maturation. The data presented here strongly suggest that insulin initiates at the cell surface a chain of events leading to GVBD. However, our studies point to the existence of certain differences between the steroid and the peptide hormone pathways, although both involve the decrease in intracellular levels of cAMP, the activation of phosphodiesterase (PDE) and the activation of pre-MPF.

Unfertilized frog eggs die by apoptosis following meiotic exit

PubMed Central

2011-01-01

Background A characteristic feature of frog reproduction is external fertilization accomplished outside the female's body. Mature fertilization-competent frog eggs are arrested at the meiotic metaphase II with high activity of the key meiotic regulators, maturation promoting factor (MPF) and cytostatic factor (CSF), awaiting fertilization. If the eggs are not fertilized within several hours of ovulation, they deteriorate and ultimately die by as yet unknown mechanism. Results Here, we report that the vast majority of naturally laid unfertilized eggs of the African clawed frog Xenopus laevis spontaneously exit metaphase arrest under various environmental conditions and degrade by a well-defined apoptotic process within 48 hours after ovulation. The main features of this process include cytochrome c release, caspase activation, ATP depletion, increase of ADP/ATP ratio, apoptotic nuclear morphology, progressive intracellular acidification, and egg swelling. Meiotic exit seems to be a prerequisite for execution of the apoptotic program, since (i) it precedes apoptosis, (ii) apoptotic events cannot be observed in the eggs maintaining high activity of MPF and CSF, and (iii) apoptosis in unfertilized frog eggs is accelerated upon early meiotic exit. The apoptotic features cannot be observed in the immature prophase-arrested oocytes, however, the maturation-inducing hormone progesterone renders oocytes susceptible to apoptosis. Conclusions The study reveals that naturally laid intact frog eggs die by apoptosis if they are not fertilized. A maternal apoptotic program is evoked in frog oocytes upon maturation and executed after meiotic exit in unfertilized eggs. The meiotic exit is required for execution of the apoptotic program in eggs. The emerging anti-apoptotic role of meiotic metaphase arrest needs further investigation. PMID:22195698

Nutrient Intake, Diet Quality, and Weight Measures in Breakfast Patterns Consumed by Children Compared with Breakfast Skippers: NHANES 2001-2008.

PubMed

O'Neil, Carol E; Nicklas, Theresa A; Fulgoni, Victor L

2015-01-01

Most studies showing that children consuming breakfast have better nutrient intakes, diet quality, and lower weight than breakfast skippers have the incorrect premise that breakfast meals are homogeneous. The purpose of this study was to classify breakfast meals into patterns and determine the association of the breakfast patterns with daily and breakfast nutrient intakes, diet quality, and weight. Data from children (2-18 years of age; N = 14,200) participating in the National Health and Nutrition Examination Survey 2001-2008 were used. Intake was determined from one day 24-hour dietary recalls. Diet quality was measured using the Healthy Eating Index-2005 (HEI-2005). Body mass index (BMI) z-scores were determined. Twelve patterns (including No Breakfast [∼19% of population]), explaining 63% of the variance in energy from breakfast, were examined. Covariate adjusted general linear models were used to compare outcome variables of consumers of different patterns with breakfast skippers. The p value was Bonferroni corrected (< 0.05/12 = < 0.0042). Consumers of the Eggs/Grain/Meat, Poultry, Fish (MPF)/ Fruit Juice (FJ) and MPF/ Grain/FJ patterns showed higher daily intakes of saturated fats, solid fats, and sodium and lower daily intakes of added sugars than breakfast skippers. Consumers of most breakfast patterns showed higher daily intakes of some nutrients of public health concern (dietary fiber, vitamin D, calcium, and potassium); however, those consuming the Grain or MPF/Grain/FJ pattern did not. Consumers of the Grain/Lower Fat Milk (LFM)/Sweets/FJ, Presweetened (PS) Ready-to-eat Cereal (RTEC)/ LFM, RTEC/LFM, Cooked Cereal/Milk/FJ, and Whole Fruit patterns had higher total HEI-2005 scores than breakfast skippers; those consuming the MPF/ Grain/FJ pattern had lower diet quality than breakfast skippers. Consumption of the Grain/ LFM/Sweets/FJ, PSRTEC/whole milk, Soft Drinks/ FJ/Grain/Potatoes, RTEC/whole milk, and Cooked Cereal/ Milk/ FJ patterns was associated with lower BMI z-scores than seen in breakfast skippers. There are dietary and weight advantages of consuming breakfast, especially breakfasts that include grains, cereals, LFM, and fruit/ FJ, in contrast to the potential adverse effects of skipping breakfast.

Practical application of a bidirectional microwave photonic filter: simultaneous transmission of analog TV signals

NASA Astrophysics Data System (ADS)

Correa-Mena, Ana Gabriela; Zaldívar-Huerta, Ignacio E.; Abril García, Jose Humberto; García-Juárez, Alejandro; Vera-Marquina, Alicia

2016-10-01

A practical application of a bidirectional microwave photonic filter (MPF) to transmit simultaneous analog TV signals coded on microwave carriers is experimentally demonstrated. The frequency response of the bidirectional MPF is obtained by the interaction of an externally modulated multimode laser diode emitting at 1.55 μm associated to the free-spectral range of the optical source, the chromatic dispersion parameter of the optical fiber, as well as the length of the optical link. The filtered microwave bandpass window generated around 2 GHz is used as electrical carrier in order to simultaneously transmit TV signals of 67.25 and 61.25 MHz in both directions. The obtained signal-to-noise ratios for the transmitted signals of 67.25 and 61.25 MHz are 37.62 and 44.77 dB, respectively.

Correlation of Rock Spectra with Quantitative Morphologic Indices: Evidence for a Single Rock Type at the Mars Pathfinder Landing Site

NASA Technical Reports Server (NTRS)

Yingst, R. A.; Biedermann, K. L.; Pierre, N. M.; Haldemann, A. F. C.; Johnson, J. R.

2005-01-01

The Mars Pathfinder (MPF) landing site was predicted to contain a broad sampling of rock types varying in mineralogical, physical, mechanical and geochemical characteristics. Although rocks have been divided into several spectral categories based on Imager for Mars Pathfinder (IMP) visible/near-infrared data, efforts in isolating and classifying spectral units among MPF rocks and soils have met with varying degrees of success, as many factors influencing spectral signatures cannot be quantified to a sufficient level to be removed. It has not been fully determined which spectral categories stem from intrinsic mineralogical differences between rocks or rock surfaces, and which result from factors such as physical or chemical weathering. This has made isolation of unique rock mineralogies difficult. Morphology, like composition, is a characteristic tied to the intrinsic properties and geologic and weathering history of rocks. Rock morphologies can be assessed quantitatively and compared with spectral data, to identify and classify rock types at the MPF landing site. They can also isolate actual rock spectra from spectral types that are surficial in origin, as compositions associated with mantling dust or chemical coatings would presumably not influence rock morphology during weathering events. We previously reported on an initial classification of rocks using the quantitative morphologic indices of size, roundness, sphericity and elongation. Here, we compare this database of rock characteristics with associated rock surface spectra to improve our ability to discriminate between spectra associated with rock types and those from other sources.

The vastus lateralis neuromuscular activity during all-out cycling exercise.

PubMed

Bercier, Stephane; Halin, Renaud; Ravier, Philippe; Kahn, Jean-Francois; Jouanin, Jean-Claude; Lecoq, Anne-Marie; Buttelli, Olivier

2009-10-01

The objective of this work was to study modifications in motor control through surface electromyographic (sEMG) activity during a very short all-out cycling exercise. Twelve male cyclists (age 23+/-4 years) participated in this study. After a warm-up period, each subject performed three all-out cycling exercises of 6s separated by 2 min of complete rest. This protocol was repeated three times with a minimum of 2 days between each session. The braking torque imposed on cycling motion was 19 Nm. The sEMG of the vastus lateralis was recorded during the first seven contractions of the sprint. Time-frequency analysis of sEMG was performed using continuous wavelet transform. The mean power frequency (MPF, qualitative modifications in the recruitment of motor units) and signal energy (a quantitative indicator of modifications in the motor units recruitment) were computed for the frequency range 10-500 Hz. sEMG energy increased (P0.05) between contraction number 1 and 2, decreased (P < or =0.05) between contraction number 2 and 3 then stabilized between contraction number 3 and 7 during the all-out test. MPF increased (P < or =0.05) during the all-out test. This increase was more marked during the first two contractions. The decrease in energy and the increase in the sEMG MPF suggest a large spatial recruitment of motor units (MUs) at the beginning of the sprint followed by a preferential recruitment of faster MUs at the end of the sprint, respectively.

Effect of transmission intensity on hotspots and micro-epidemiology of malaria in sub-Saharan Africa.

PubMed

Mogeni, Polycarp; Omedo, Irene; Nyundo, Christopher; Kamau, Alice; Noor, Abdisalan; Bejon, Philip

2017-06-30

Malaria transmission intensity is heterogeneous, complicating the implementation of malaria control interventions. We provide a description of the spatial micro-epidemiology of symptomatic malaria and asymptomatic parasitaemia in multiple sites. We assembled data from 19 studies conducted between 1996 and 2015 in seven countries of sub-Saharan Africa with homestead-level geospatial data. Data from each site were used to quantify spatial autocorrelation and examine the temporal stability of hotspots. Parameters from these analyses were examined to identify trends over varying transmission intensity. Significant hotspots of malaria transmission were observed in most years and sites. The risk ratios of malaria within hotspots were highest at low malaria positive fractions (MPFs) and decreased with increasing MPF (p < 0.001). However, statistical significance of hotspots was lowest at extremely low and extremely high MPFs, with a peak in statistical significance at an MPF of ~0.3. In four sites with longitudinal data we noted temporal instability and variable negative correlations between MPF and average age of symptomatic malaria across all sites, suggesting varying degrees of temporal stability. We observed geographical micro-variation in malaria transmission at sites with a variety of transmission intensities across sub-Saharan Africa. Hotspots are marked at lower transmission intensity, but it becomes difficult to show statistical significance when cases are sparse at very low transmission intensity. Given the predictability with which hotspots occur as transmission intensity falls, malaria control programmes should have a low threshold for responding to apparent clustering of cases.

Involvement of the dehydroleucodine alpha-methylene-gamma-lactone function in GVBD inhibition in Bufo arenarum oocytes.

PubMed

Sánchez Toranzo, G; López, L A; Martínez, J Zapata; Bühler, M C Gramajo; Bühler, M I

2010-02-01

Dehydroleucodine (DhL), a sesquiterpenic lactone, was isolated and purified from aerial parts of Artemisia douglasiana Besser, a medicinal herb used in Argentina. DhL is an alpha-methylene butyro-gamma-lactone ring connected to a seven-membered ring fused to an exocyclic alpha,beta-unsaturated cyclopentenone ring. It has been previously shown that DhL selectively induces a dose-dependent transient arrest in G2 of both meristematic cells and vascular smooth muscle cells. Treatment with DhL induces an inhibition of spontaneous and progesterone-induced maturation in a dose-dependent manner in Bufo arenarum fully grown oocytes arrested at G2, at the beginning of meiosis I. However, the nature of the mechanisms involved in the process is still unknown. The aim of this work was to analyse whether DhL's alpha-methylene-gamma-lactone function is responsible for the inhibition effect on meiosis reinitiation of Bufo arenarum oocytes as well as some of the transduction pathways that could be involved in this effect using a derivative of DhL inactivated for alpha-methylenelactone, the 11,13-dihydro-dehydroleucodine (2H-DhL). The use of 2H-DhL in the maturation promoting factor (MPF) amplification experiments by injection of both cytoplasm with active MPF and of germinal vesicle content showed results similar to the ones obtained with DhL, suggesting that the hydrogenated derivative would act in a similar way to DhL. Pretreatment with DhL or 2H-DhL did not affect the percentage of germinal vesicle breakdown (GVBD) induced by H89, a protein kinase A (PKA) inhibitor, which suggests that these lactones would act on another step of the signalling pathway that induces MPF activation. The fact that both DhL and 2H-Dhl inhibit GVBD induced by okadaic acid microinjection suggests that they could act on the activity of the Myt1 kinase. This idea is supported by the experiments of injection of GV contents in which an inhibitory effect of these lactones on GVBD was also observed. Our results indicate that the inhibitory effect on meiosis progression of DhL does not depend only on the activity of the alpha-methylenelactone function, as its hydrogenated derivative, 2H-DhL, in which this function has been inactivated, causes similar effects on amphibian oocytes. However, 2H-DhL was less active than DhL as higher doses were required to obtain a significant inhibition. On the other hand, the analysis of the participation of certain mediators in some of the signalling pathways leading to MPF activation suggests that the Myt1 kinase could be a target of these lactones, while cdc25 phosphatase would not be affected. Besides, the PKA inhibition assays indicate that these lactones would act earlier in the signalling pathways.

The challenge associated with the robust computation of meteor velocities from video and photographic records

NASA Astrophysics Data System (ADS)

Egal, A.; Gural, P. S.; Vaubaillon, J.; Colas, F.; Thuillot, W.

2017-09-01

The CABERNET project was designed to push the limits for obtaining accurate measurements of meteoroids orbits from photographic and video meteor camera recordings. The discrepancy between the measured and theoretic orbits of these objects heavily depends on the semi-major axis determination, and thus on the reliability of the pre-atmospheric velocity computation. With a spatial resolution of 0.01° per pixel and a temporal resolution of up to 10 ms, CABERNET should be able to provide accurate measurements of velocities and trajectories of meteors. To achieve this, it is necessary to improve the precision of the data reduction processes, and especially the determination of the meteor's velocity. In this work, most of the steps of the velocity computation are thoroughly investigated in order to reduce the uncertainties and error contributions at each stage of the reduction process. The accuracy of the measurement of meteor centroids is established and results in a precision of 0.09 pixels for CABERNET, which corresponds to 3.24‧‧. Several methods to compute the velocity were investigated based on the trajectory determination algorithms described in Ceplecha (1987) and Borovicka (1990), as well as the multi-parameter fitting (MPF) method proposed by Gural (2012). In the case of the MPF, many optimization methods were implemented in order to find the most efficient and robust technique to solve the minimization problem. The entire data reduction process is assessed using simulated meteors, with different geometrical configurations and deceleration behaviors. It is shown that the multi-parameter fitting method proposed by Gural(2012)is the most accurate method to compute the pre-atmospheric velocity in all circumstances. Many techniques that assume constant velocity at the beginning of the path as derived from the trajectory determination using Ceplecha (1987) or Borovicka (1990) can lead to large errors for decelerating meteors. The MPF technique also allows one to reliably compute the velocity for very low convergence angles (∼ 1°). Despite the better accuracy of this method, the poor conditioning of the velocity propagation models used in the meteor community and currently employed by the multi-parameter fitting method prevent us from optimally computing the pre-atmospheric velocity. Specifically, the deceleration parameters are particularly difficult to determine. The quality of the data provided by the CABERNET network limits the error induced by this effect to achieve an accuracy of about 1% on the velocity computation. Such a precision would not be achievable with lower resolution camera networks and today's commonly used trajectory reduction algorithms. To improve the performance of the multi-parameter fitting method, a linearly independent deceleration formulation needs to be developed.

Operations and Autonomy of the Mars Pathfinder Microrover

NASA Technical Reports Server (NTRS)

Mishkin, A. H.; Morrison, J. C.; Nguyen, T. T.; Stone, H. W.; Cooper, B. K.

1998-01-01

The Microrover Flight Experiment (MFEX) is a NSAS OACT (Office of Advanced Concepts and Technology) flight experiment which, integrated with the Mars Pathfinder (MPF) lander and spacecraft system, landed on Mars on July 4, 1997.

Improved MPF 360-degree Color Panorama

NASA Image and Video Library

1999-03-19

This is a more recent geometrically improved, color enhanced version of the 360-degree Gallery Pan, the first contiguous, uniform panorama taken by the Imager for Mars IMP over the course of Sols 8, 9, and 10.

Demodulation of an optical fiber MEMS pressure sensor based on single bandpass microwave photonic filter.

PubMed

Wang, Yiping; Ni, Xiaoqi; Wang, Ming; Cui, Yifeng; Shi, Qingyun

2017-01-23

In this paper, a demodulation method for optic fiber micro-electromechanical systems (MEMS) extrinsic Fabry-Perot interferometer (EFPI) pressure sensor exploiting microwave photonics filter technique is firstly proposed and experimentally demonstrated. A single bandpass microwave photonic filter (MPF) which mainly consists of a spectrum-sliced light source, a pressurized optical fiber MEMS EFPI, a phase modulator (PM) and a length of dispersion compensating fiber (DCF) is demonstrated. The frequency response of the filter with respect to the pressure is studied. By detecting the resonance frequency shifts of the MPF, the pressure can be determined. The theoretical and experimental results show that the proposed EFPI pressure demodulation method has a higher resolution and higher speed than traditional methods based on optical spectrum analysis. The sensitivity of the sensor is measured to be as high as 86 MHz/MPa in the range of 0-4Mpa. Moreover, the sensitivity can be easily adjusted.

Pension reforms in Hong Kong: using residual and collaborative strategies to deal with the government's financial responsibility in providing retirement protection.

PubMed

Yu, Sam Wai-Kam

2008-01-01

In 2000, the Hong Kong government introduced the first compulsory retirement saving scheme intended to protect the entire workforce, the Mandatory Provident Fund (MPF). Prior to the introduction of this scheme, the government's main measure for giving financial protection to retirees was the Comprehensive Social Security Assistance (CSSA) scheme, which is a noncontributory, means-tested financial assistance scheme. This paper studies the government's attempt to introduce the MPF on top of the CSSA scheme as a means to illustrate how governments might address their financial responsibilities in providing pension schemes by adopting both the residual strategy-centered reform approach and the collaborative strategy-centered reform approach. The former approach is concerned with developing noncontributory schemes using residual strategies, and the latter is concerned with developing contributory schemes using collaborative strategies. The paper shows the difficulties involved in carrying out these two reform approaches simultaneously.

Analysis of linear electrode array EMG for assessment of hemiparetic biceps brachii muscles.

PubMed

Yao, Bo; Zhang, Xu; Li, Sheng; Li, Xiaoyan; Chen, Xiang; Klein, Cliff S; Zhou, Ping

2015-01-01

This study presents a frequency analysis of surface electromyogram (EMG) signals acquired by a linear electrode array from the biceps brachii muscles bilaterally in 14 hemiparetic stroke subjects. For different levels of isometric contraction ranging from 10 to 80% of the maximum voluntary contraction (MVC), the power spectra of 19 bipolar surface EMG channels arranged proximally to distally along the muscle fibers were examined in both paretic and contralateral muscles. It was found that across all stroke subjects, the median frequency (MF) and the mean power frequency (MPF), averaged from different surface EMG channels, were significantly smaller in the paretic muscle compared to the contralateral muscle at each of the matched percent MVC contractions. The muscle fiber conduction velocity (MFCV) was significantly slower in the paretic muscle than in the contralateral muscle. No significant correlation between the averaged MF, MPF, or MFCV vs. torque was found in both paretic and contralateral muscles. However, there was a significant positive correlation between the global MFCV and MF. Examination of individual EMG channels showed that electrodes closest to the estimated muscle innervation zones produced surface EMG signals with significantly higher MF and MPF than more proximal or distal locations in both paretic and contralateral sides. These findings suggest complex central and peripheral neuromuscular alterations (such as selective loss of large motor units, disordered control of motor units, increased motor unit synchronization, and atrophy of muscle fibers, etc.) which can collectively influence the surface EMG signals. The frequency difference with regard to the innervation zone also confirms the relevance of electrode position in surface EMG analysis.

Role of cytoskeleton in regulating fusion of nucleoli: a study using the activated mouse oocyte model.

PubMed

Lian, Hua-Yu; Jiao, Guang-Zhong; Wang, Hui-Li; Tan, Xiu-Wen; Wang, Tian-Yang; Zheng, Liang-Liang; Kong, Qiao-Qiao; Tan, Jing-He

2014-09-01

Although fusion of nucleoli was observed during pronuclear development of zygotes and the behavior of nucleoli in pronuclei has been suggested as an indicator of embryonic developmental potential, the mechanism for nucleolar fusion is unclear. Although both cytoskeleton and the nucleolus are important cellular entities, there are no special reports on the relationship between the two. Role of cytoskeleton in regulating fusion of nucleoli was studied using the activated mouse oocyte model. Mouse oocytes were cultured for 6 h in activating medium (Ca²⁺-free CZB medium containing 10 mM SrCl₂) supplemented with or without inhibitors for cytoskeleton or protein synthesis before pronuclear formation, nucleolar fusion, and the activity of maturation-promoting factor (MPF) were examined. Whereas treatment with microfilament inhibitor cytochalasin D or B or intermediate filament inhibitor acrylamide suppressed nucleolar fusion efficiently, treatment with microtubule inhibitor demecolcine or nocodazole or protein synthesis inhibitor cycloheximide had no effect. The cytochalasin D- or acrylamide-sensitive temporal window coincided well with the reported temporal window for nucleolar fusion in activated oocytes. Whereas a continuous incubation with demecolcine prevented pronuclear formation, pronuclei formed normally when demecolcine was excluded during the first hour of activation treatment when the MPF activity dropped dramatically. The results suggest that 1) microfilaments and intermediate filaments but not microtubules support nucleolar fusion, 2) proteins required for nucleolar fusion including microfilaments and intermediate filaments are not de novo synthesized, and 3) microtubule disruption prevents pronuclear formation by activating MPF. © 2014 by the Society for the Study of Reproduction, Inc.

Myoelectrical Manifestation of Fatigue Less Prominent in Patients with Cancer Related Fatigue

PubMed Central

Kisiel-Sajewicz, Katarzyna; Siemionow, Vlodek; Seyidova-Khoshknabi, Dilara; Davis, Mellar P.; Wyant, Alexandria; Ranganathan, Vinoth K.; Walsh, Declan; Yan, Jin H.; Hou, Juliet; Yue, Guang H.

2013-01-01

Purpose A lack of fatigue-related muscle contractile property changes at time of perceived physical exhaustion and greater central than peripheral fatigue detected by twitch interpolation technique have recently been reported in cancer survivors with fatigue symptoms. Based on these observations, it was hypothesized that compared to healthy people, myoelectrical manifestation of fatigue in the performing muscles would be less significant in these individuals while sustaining a prolonged motor task to self-perceived exhaustion (SPE) since their central fatigue was more prominent. The purpose of this study was to test this hypothesis by examining electromyographic (EMG) signal changes during fatiguing muscle performance. Methods Twelve individuals who had advanced solid cancer and cancer-related fatigue (CRF), and 12 age- and gender-matched healthy controls performed a sustained elbow flexion at 30% maximal voluntary contraction till SPE. Amplitude and mean power frequency (MPF) of EMG signals of the biceps brachii, brachioradialis, and triceps brachii muscles were evaluated when the individuals experienced minimal, moderate, and severe fatigue. Results CRF patients perceived physical “exhaustion” significantly sooner than the controls. The myoelectrical manifestation of muscular fatigue assessed by EMG amplitude and MPF was less significant in CRF than controls. The lower MPF even at minimal fatigue stage in CRF may indicate pathophysiologic condition of the muscle. Conclusions CRF patients experience less myoelectrical manifestation of muscle fatigue than healthy individuals near the time of SPE. The data suggest that central nervous system fatigue plays a more important role in limiting endurance-type of motor performance in patients with CRF. PMID:24391800

Nutrient Intake, Diet Quality, and Weight Measures in Breakfast Patterns Consumed by Children Compared with Breakfast Skippers: NHANES 2001–2008

PubMed Central

O'Neil, Carol E.; Nicklas, Theresa A.; Fulgoni, Victor L.

2015-01-01

Most studies showing that children consuming breakfast have better nutrient intakes, diet quality, and lower weight than breakfast skippers have the incorrect premise that breakfast meals are homogeneous. The purpose of this study was to classify breakfast meals into patterns and determine the association of the breakfast patterns with daily and breakfast nutrient intakes, diet quality, and weight. Data from children (2–18 years of age; N = 14,200) participating in the National Health and Nutrition Examination Survey 2001–2008 were used. Intake was determined from one day 24-hour dietary recalls. Diet quality was measured using the Healthy Eating Index-2005 (HEI-2005). Body mass index (BMI) z-scores were determined. Twelve patterns (including No Breakfast [∼19% of population]), explaining 63% of the variance in energy from breakfast, were examined. Covariate adjusted general linear models were used to compare outcome variables of consumers of different patterns with breakfast skippers. The p value was Bonferroni corrected (< 0.05/12 = < 0.0042). Consumers of the Eggs/Grain/Meat, Poultry, Fish (MPF)/ Fruit Juice (FJ) and MPF/ Grain/FJ patterns showed higher daily intakes of saturated fats, solid fats, and sodium and lower daily intakes of added sugars than breakfast skippers. Consumers of most breakfast patterns showed higher daily intakes of some nutrients of public health concern (dietary fiber, vitamin D, calcium, and potassium); however, those consuming the Grain or MPF/Grain/FJ pattern did not. Consumers of the Grain/Lower Fat Milk (LFM)/Sweets/FJ, Presweetened (PS) Ready-to-eat Cereal (RTEC)/ LFM, RTEC/LFM, Cooked Cereal/Milk/FJ, and Whole Fruit patterns had higher total HEI-2005 scores than breakfast skippers; those consuming the MPF/ Grain/FJ pattern had lower diet quality than breakfast skippers. Consumption of the Grain/ LFM/Sweets/FJ, PSRTEC/whole milk, Soft Drinks/ FJ/Grain/Potatoes, RTEC/whole milk, and Cooked Cereal/ Milk/ FJ patterns was associated with lower BMI z-scores than seen in breakfast skippers. There are dietary and weight advantages of consuming breakfast, especially breakfasts that include grains, cereals, LFM, and fruit/ FJ, in contrast to the potential adverse effects of skipping breakfast. PMID:29546119

Grain coarsening in two-dimensional phase-field models with an orientation field

NASA Astrophysics Data System (ADS)

Korbuly, Bálint; Pusztai, Tamás; Henry, Hervé; Plapp, Mathis; Apel, Markus; Gránásy, László

2017-05-01

In the literature, contradictory results have been published regarding the form of the limiting (long-time) grain size distribution (LGSD) that characterizes the late stage grain coarsening in two-dimensional and quasi-two-dimensional polycrystalline systems. While experiments and the phase-field crystal (PFC) model (a simple dynamical density functional theory) indicate a log-normal distribution, other works including theoretical studies based on conventional phase-field simulations that rely on coarse grained fields, like the multi-phase-field (MPF) and orientation field (OF) models, yield significantly different distributions. In a recent work, we have shown that the coarse grained phase-field models (whether MPF or OF) yield very similar limiting size distributions that seem to differ from the theoretical predictions. Herein, we revisit this problem, and demonstrate in the case of OF models [R. Kobayashi, J. A. Warren, and W. C. Carter, Physica D 140, 141 (2000), 10.1016/S0167-2789(00)00023-3; H. Henry, J. Mellenthin, and M. Plapp, Phys. Rev. B 86, 054117 (2012), 10.1103/PhysRevB.86.054117] that an insufficient resolution of the small angle grain boundaries leads to a log-normal distribution close to those seen in the experiments and the molecular scale PFC simulations. Our paper indicates, furthermore, that the LGSD is critically sensitive to the details of the evaluation process, and raises the possibility that the differences among the LGSD results from different sources may originate from differences in the detection of small angle grain boundaries.

Neuromuscular function during knee extension exercise after cold water immersion.

PubMed

Wakabayashi, Hitoshi; Wijayanto, Titis; Tochihara, Yutaka

2017-06-23

Human adaptability to cold environment has been focused on in the physiological anthropology and related research area. Concerning the human acclimatization process in the natural climate, it is necessary to conduct a research assessing comprehensive effect of cold environment and physical activities in cold. This study investigated the effect of cold water immersion on the exercise performance and neuromuscular function during maximal and submaximal isometric knee extension. Nine healthy males participated in this study. They performed maximal and submaximal (20, 40, and 60% maximal load) isometric knee extension pre- and post-immersion in 23, 26, and 34 °C water. The muscle activity of the rectus femoris (RF) and vastus lateralis (VL) was measured using surface electromyography (EMG). The percentages of the maximum voluntary contraction (%MVC) and mean power frequency (MPF) of EMG data were analyzed. The post-immersion maximal force was significantly lower in 23 °C than in 26 and 34 °C conditions (P < 0.05). The post-immersion %MVC of RF was significantly higher than pre-immersion during 60% maximal exercise in 23 and 26 °C conditions (P < 0.05). In the VL, the post-immersion %MVC was significantly higher than pre-immersion in 23 and 26 °C conditions during 20% maximal exercise and in 26 °C at 40 and 60% maximal intensities (P < 0.05). The post-immersion %MVC of VL was significantly higher in 26 °C than in 34 °C at 20 and 60% maximal load (P < 0.05). The post-immersion MPF of RF during 20% maximal intensity was significantly lower in 23 °C than in 26 and 34 °C conditions (P < 0.05), and significantly different between three water temperature conditions at 40 and 60% maximal intensities (P < 0.05). The post-immersion MPF of VL during three submaximal trials were significantly lower in 23 and 26 °C than in 34 °C conditions (P < 0.05). The lower shift of EMG frequency would be connected with the decrease in the nerve and muscle fibers conduction velocity. To compensate for the impairment of each muscle fibers function, more muscle fibers might be recruited to maintain the working load. This might result in the greater amplitude of EMG after the cold immersion.

MPF Lander Measured Surface Pressure

NASA Image and Video Library

1997-10-14

In this figure from NASA's Mars Pathfinder, you can see a significant increase in pressure on Sol 81, Sept. 25 1997. This is an indication of a frontal system has moved across the landing sight. http://photojournal.jpl.nasa.gov/catalog/PIA00977

Resource Letter MPF-1: Mechanical Properties of Fluids

ERIC Educational Resources Information Center

Stanley, R. C.

1974-01-01

Presents an annotated bibliography concerning the mechanical properties of fluids, including topics for use at elementary, secondary, undergraduate, and graduate levels. Indicates that the material can particularly help college physicists in improving course contents in specified fields of physics. (CC)

Participation of IP3R, RyR and L-type Ca2+ channel in the nuclear maturation of Rhinella arenarum oocytes.

PubMed

Toranzo, G Sánchez; Bühler, M C Gramajo; Bühler, M I

2014-05-01

During meiosis resumption, oocytes undergo a series of nuclear and cytosolic changes that prepare them for fertilization and that are referred to as oocyte maturation. These events are characterized by germinal vesicle breakdown (GVBD), chromatin condensation and spindle formation and, among cytosolic changes, organelle redistribution and maturation of Ca2+-release mechanisms. The progression of the meiotic cell cycle is regulated by M phase/maturation-promoting factor (MPF) and mitogen-activated protein kinase (MAPK). Changes in the levels of intracellular free Ca2+ ion have also been implicated strongly in the triggering of the initiation of the M phase. Ca2+ signals can be generated by Ca2+ release from intracellular Ca2+ stores (endoplasmic reticulum; ER) or by Ca2+ influx from the extracellular space. In this sense, the L-type Ca2+ channel plays an important role in the incorporation of Ca2+ from the extracellular space. Two types of intracellular Ca2+ receptor/channels are known to mediate the intracellular Ca2+ release from the ER lumen. The most abundant, the inositol 1,4,5-trisphosphate receptor (IP3R), and the other Ca2+ channel, the ryanodine receptor (RyR), have also been reported to mediate Ca2+ release in several oocytes. In amphibians, MPF and MAPK play a central role during oocyte maturation, controlling several events. However, no definitive relationships have been identified between Ca2+ and MPF or MAPK. We investigated the participation of Ca2+ in the spontaneous and progesterone-induced nuclear maturation in Rhinella arenarum oocytes and the effect of different pharmacological agents known to produce modifications in the Ca2+ channels. We demonstrated that loading competent and incompetent oocytes with the intracellular calcium chelator BAPTA/AM produced suppression of spontaneous and progesterone-induced GVBD. In our results, the capacity of progesterone to trigger meiosis reinitiation in Rhinella in the presence of L-type Ca2+ channel blockers (nifedipine and lanthane) indicated that spontaneous and progesterone-induced maturation would be independent of extracellular calcium influx, but would be sensitive to intracellular Ca2+ deprivation. As demonstrated by the effect of thimerosal and heparin in Rhinella arenarum, the intracellular increase in Ca2+ during maturation is also mediated mainly by IP3R. In addition, our results using caffeine, an agonist of the RyR, could suggest that Ca2+ release from ryanodine-sensitive stores is not essential for oocyte maturation in Rhinella. The decrease in MPF activity with NaVO3 negatively affected the percentage of thimerosal-induced GVBD. This finding suggests that Ca2+ release through the IP3R could be involved in the signalling pathway that induces MPF activation. However, the inhibition of MAP/ERK kinase (MEK) by PD98128 or P90 by geldanamycin produced a significant decrease in the percentages of GVBD induced by thimerosal. This finding suggests that Ca2+ release per se cannot bypass the inhibition of the MAPK activity.

Classification and Distribution of Mars Pathfinder Rocks Using Quantitative Morphologic Indices

NASA Technical Reports Server (NTRS)

Yingst, R. A.; Biederman, K. L.; Monhead, A. M.; Haldemann, A. F. C.; Kowalczyk, M. R.

2004-01-01

The Mars Pathfinder (MPF) landing site was predicted to contain a broad sampling of rock types varying in mineralogical, physical, mechanical and geochemical characteristics. Although rocks have been divided into several spectral categories based on Imager for Mars Pathfinder visible/near-infrared spectra, it has not been fully determined which of these stem from intrinsic mineralogical differences between rocks or rock surfaces, and which result from factors such as physical or chemical weathering. This has made isolation of unique mineralogy's difficult. Efforts in isolating and classifying spectral units among MPF rocks and soils have met with varying degrees of success, and the current understanding is such that many factors influencing spectral signatures cannot be quantified to a sufficient level so they may be removed. The result is that fundamental questions regarding information needed to reveal the present and past interactions between the rocks and rock surfaces and the Martian environment remain unanswered. But it is possible to approach the issue of identifying distinct rock and rock surface types from a different angle.

Hydrodynamic optimality of balistiform and gymnotiform locomotion

NASA Astrophysics Data System (ADS)

Sprinkle, Brennan; Bale, Rahul; Bhalla, Amneet Pal Singh; MacIver, Malcolm A.; Patankar, Neelesh A.

2017-03-01

Some groups of fish have evolved to generate propulsion using undulatory elongated fins while maintaining a relatively rigid body. The fins run along the body axis and can be dorsal, ventral, dorsoventral pairs or left-right pairs. These fish are termed as median/paired fin (MPF) swimmers. The movement of these groups of fish was studied in an influential series of papers by Lighthill and Blake. In this work, we revisit this problem by performing direct numerical simulations. We interrogate two issues. First, we investigate and explain a key morphological feature, which is the diagonal fin insertion found in many MPF swimmers such as the knifefish. Not only are these results of biological relevance, but these are also useful in engineering to design bioinspired highly maneuverable underwater vehicles. Second, we investigate whether there is a mechanical advantage in the form of reduced cost of transport (COT) (energy spent per unit distance traveled) for not undulating the entire body. We find that a rigid body attached to an undulating fin leads to a reduced COT.

Inference of genetic network of Xenopus frog egg: improved genetic algorithm.

PubMed

Wu, Shinq-Jen; Chou, Chia-Hsien; Wu, Cheng-Tao; Lee, Tsu-Tian

2006-01-01

An improved genetic algorithm (IGA) is proposed to achieve S-system gene network modeling of Xenopus frog egg. Via the time-courses training datasets from Michaelis-Menten model, the optimal parameters are learned. The S-system can clearly describe activative and inhibitory interaction between genes as generating and consuming process. We concern the mitotic control in cell-cycle of Xenopus frog egg to realize cyclin-Cdc2 and Cdc25 for MPF activity. The proposed IGA can achieve global search with migration and keep the best chromosome with elitism operation. The generated gene regulatory networks can provide biological researchers for further experiments in Xenopus frog egg cell cycle control.

Participation of MAPK, PKA and PP2A in the regulation of MPF activity in Bufo arenarum oocytes.

PubMed

Toranzo, G Sánchez; Bonilla, F; Bühler, M C Gramajo; Bühler, M I

2011-05-01

The objectives of the present paper were to study the involvement and possible interactions of both cAMP-PKA and protein phosphatases in Bufo arenarum oocyte maturation and to determine if these pathways are independent or not of the MAP kinase (MAPK) cascade. Our results indicated that the inhibition of PKA by treatment with H-89, an inhibitor of the catalytic subunit of PKA, was capable of inducing GVBD in a dose-dependent manner by a pathway in which Cdc25 phosphatase but not the MAPK cascade is involved. The injection of 50 nl of H-89 10 μM produced GVBD percentages similar to those obtained with treatment with progesterone. In addition, the assays with okadaic acid (OA), a PP2A inhibitor, significantly enhanced the percentage of oocytes that resumed meiosis by a signal transducing pathway in which the activation of the MEK-MAPK pathway is necessary, but in which Cdc25 phosphatase was not involved. Treatment with H-89, was able to overcome the inhibitory effect of PKA on GVBD; however, the inhibition of Cdc25 activity with NaVO3 was able to overcome the induction of GVBD by H-89. Although the connections between PKA and other signalling molecules that regulate oocytes maturation are still unclear, our results suggest that phosphatase Cdc25 may be the direct substrate of PKA. In Xenopus oocytes it was proposed that PP2A, a major Ser/Thr phosphatase present, is a negative regulator of Cdc2 activation. However, in Bufo arenarum oocytes, inhibition of Cdc25 with NaVO₃ did not inhibit OA-induced maturation, suggesting that the target of PP2A was not the Cdc25 phosphatase. MAPK activation has been reported to be essential in Xenopus oocytes GVBD. In B. arenarum oocytes we demonstrated that the inhibition of MAPK by PD 98059 prevented the activation of MPF induced by OA, suggesting that the activation of the MAPK cascade produced an inhibition of Myt1 and, in consequence, the activation of MPF without participation of the Cdc25 phosphatase. Our results suggest that in incompetent oocytes of B. arenarum two signal transduction pathways may be involved in the control of MPF activation: (1) the inhibition of phosphatase 2A that through the MEK-MAPK pathway regulates the activity of the Myt1; and (2) the inhibition of AMPc-PKA, which affects the activity of the Cdc25 phosphatase.

Experimentally induced central sensitization in the cervical spine evokes postural stiffening strategies in healthy young adults.

PubMed

Huntley, Andrew H; Srbely, John Z; Zettel, John L

2015-02-01

Dysequilibrium of cervicogenic origin can result from pain and injury to cervical paraspinal tissues post-whiplash; however, the specific physiological mechanisms still remain unclear. Central sensitization is a neuradaptive process which has been clinically associated with conditions of chronic pain and hypersensitivity. Strong links have been demonstrated between pain hypersensitivity and postural deficits post-whiplash; however, the precise mechanisms are still poorly understood. The purpose of this study was to explore the mechanisms of cervicogenic disequilibrium by investigating the effect of experimentally induced central sensitization in the cervical spine on postural stability in young healthy adults. Sixteen healthy young adults (7 males (22.6±1.13 years) and 9 females (22±2.69 years)) performed 30-s full-tandem stance trials on an AMTI force plate under normal and centrally sensitized conditions. The primary outcome variables included the standard deviation of the center of pressure (COP) position in medio-lateral (M-L) and antero-posterior (A-P) directions; sway range of the COP in M-L and A-P directions and the mean power frequency (MPF) of the COP and horizontal ground shear forces. Variability and sway range of the COP decreased with experimental induction of central sensitization, accompanied by an increase in MPF of COP displacement in both M-L and A-P directions, suggesting an increase in postural stiffening post-sensitization versus non-sensitized controls. Future studies need to further explore this relationship in clinical (whiplash, chronic pain) populations. Copyright © 2015 Elsevier B.V. All rights reserved.

77 FR 70444 - Agency Information Collection Activities: Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-26

... Collection Request: New collection; Title: Medicare Plan Finder Experiment; Use: The mission of the Centers... experimental design to assess the effectiveness of two potential enhancements to the Medicare Plan Finder tool... experiment is to test the effects of two prospective enhancements to the Medicare Plan Finder (MPF) Web site...

Patterns of Change in Collaboration Are Associated with Baseline Characteristics and Predict Outcome and Dropout Rates in Treatment of Multi-Problem Families. A Validation Study

PubMed Central

Bachler, Egon; Fruehmann, Alexander; Bachler, Herbert; Aas, Benjamin; Nickel, Marius; Schiepek, Guenter K.

2017-01-01

Objective: The present study validates the Multi-Problem Family (MPF)-Collaboration Scale), which measures the progress of goal directed collaboration of patients in the treatment of families with MPF and its relation to drop-out rates and treatment outcome. Method: Naturalistic study of symptom and competence-related changes in children of ages 4–18 and their caregivers. Setting: Integrative, structural outreach family therapy. Measures: The data of five different groups of goal directed collaboration (deteriorating collaboration, stable low collaboration, stable medium collaboration, stable high collaboration, improving collaboration) were analyzed in their relation to treatment expectation, individual therapeutic goals (ITG), family adversity index, severity of problems and global assessment of a caregiver’s functioning, child, and relational aspects. Results: From N = 810 families, 20% displayed stable high collaboration (n = 162) and 21% had a pattern of improving collaboration. The families with stable high or improving collaboration rates achieved significantly more progress throughout therapy in terms of treatment outcome expectancy (d = 0.96; r = 0.43), reaching ITG (d = 1.17; r = 0.50), family adversities (d = 0.55; r = 0.26), and severity of psychiatric symptoms (d = 0.31; r = 0.15). Furthermore, families with stable high or improving collaboration maintained longer treatments and had a bigger chance of finishing the therapy as planned. The odds of having a stable low or deteriorating collaboration throughout treatment were significantly higher for subjects who started treatment with low treatment expectation or high family-related adversities. Conclusion: The positive outcomes of homebased interventions for multi-problem families are closely related to “stable high” and an “improving” collaboration as measured with the MPF-Collaboration Scale. Patients who fall into these groups have a high treatment outcome expectancy and reduce psychological stress. For therapeutic interventions with multi-problem families it seems beneficial to maintain a stable high collaboration or help the collaboration, e.g., by fostering treatment expectation. PMID:28785232

Post-fusion treatment with MG132 increases transcription factor expression in somatic cell nuclear transfer embryos in pigs.

PubMed

You, Jinyoung; Lee, Joohyeong; Kim, Jinyoung; Park, Junhong; Lee, Eunsong

2010-02-01

The objective of this study was to examine the effect of post-fusion treatment of somatic cell nuclear transfer (SCNT) oocytes with the proteasomal inhibitor MG132 on maturation promoting factor (MPF) activity, nuclear remodeling, embryonic development, and gene expression of cloned pig embryos. Immediately after electrofusion, SCNT oocytes were treated with MG132 and/or caffeine for 2 hr, vanadate for 0.5 hr, or vanadate for 0.5 hr followed by MG132 for 1.5 hr. Of the MG132 concentrations tested (0-5 microM), the 1 microM concentration showed a higher rate of blastocyst formation (25.9%) than 0 (14.2%), 0.5 (16.9%), and 5 microM (16.9%). Post-fusion treatment with MG132, caffeine, and both MG132 and caffeine improved blastocyst formation (22.1%, 21.4%, and 24.4%, respectively), whereas vanadate treatment inhibited blastocyst formation (6.5%) compared to the control (11.1%). When examined 2 hr after fusion and 1 hr after activation, MPF activity remained at a higher (P < 0.05) level in SCNT oocytes that were treated post-fusion with caffeine and/or MG132, but it was decreased by vanadate. The rate of oocytes showing premature chromosome condensation was not altered by MG132 but was decreased by vanadate treatment. In addition, formation of single pronuclei was increased by MG132 compared to control and vanadate treatment. MG132-treated embryos showed increased expression of POU5F1, DPPA2, DPPA3, DPPA5, and NDP52l1 genes compared to control embryos. Our results demonstrate that post-fusion treatment of SCNT oocytes with MG132 prevents MPF degradation and increases expression of transcription factors in SCNT embryos, which are necessary for normal development of SCNT embryos. (c) 2009 Wiley-Liss, Inc.

Timing of metamorphism of the Lansang gneiss and implications for left-lateral motion along the Mae Ping (Wang Chao) strike-slip fault, Thailand

NASA Astrophysics Data System (ADS)

Palin, R. M.; Searle, M. P.; Morley, C. K.; Charusiri, P.; Horstwood, M. S. A.; Roberts, N. M. W.

2013-10-01

The Mae Ping fault (MPF), western Thailand, exhibits dominantly left-lateral strike-slip motion and stretches for >600 km, reportedly branching off the right-lateral Sagaing fault in Myanmar and extending southeast towards Cambodia. Previous studies have suggested that the fault assisted the large-scale extrusion of Sundaland that occurred during the Late Eocene-Early Oligocene, with a geological offset of ˜120-150 km estimated from displaced high-grade gneisses and granites of the Chiang Mai-Lincang belt. Exposures of high-grade orthogneiss in the Lansang National Park, part of this belt, locally contain strong mylonitic textures and are bounded by strike-slip ductile shear zones and brittle faults. Geochronological analysis of monazite from a sample of sheared biotite-K-feldspar orthogneiss suggests two episodes of crystallization, with core regions documenting Th-Pb ages between c. 123 and c. 114 Ma and rim regions documenting a significantly younger age range between c. 45-37 Ma. These data are interpreted to represent possible magmatic protolith emplacement for the Lansang orthogneiss during the Early Cretaceous, with a later episode of metamorphism occurring during the Eocene. Textural relationships provided by in situ analysis suggest that ductile shearing along the MPF occurred during the latter stages of, or after, this metamorphic event. In addition, monazite analyzed from an undeformed garnet-two-mica granite dyke intruding metamorphic units at Bhumipol Lake outside of the Mae Ping shear zone produced a Th-Pb age of 66.2 ± 1.6 Ma. This age is interpreted to date the timing of dyke emplacement, implying that the MPF cuts through earlier formed magmatic and high-grade metamorphic rocks. These new data, when combined with regional mapping and earlier geochronological work, show that neither metamorphism, nor regional cooling, was directly related to strike-slip motion.

A new approach to compute accurate velocity of meteors

NASA Astrophysics Data System (ADS)

Egal, Auriane; Gural, Peter; Vaubaillon, Jeremie; Colas, Francois; Thuillot, William

2016-10-01

The CABERNET project was designed to push the limits of meteoroid orbit measurements by improving the determination of the meteors' velocities. Indeed, despite of the development of the cameras networks dedicated to the observation of meteors, there is still an important discrepancy between the measured orbits of meteoroids computed and the theoretical results. The gap between the observed and theoretic semi-major axis of the orbits is especially significant; an accurate determination of the orbits of meteoroids therefore largely depends on the computation of the pre-atmospheric velocities. It is then imperative to dig out how to increase the precision of the measurements of the velocity.In this work, we perform an analysis of different methods currently used to compute the velocities and trajectories of the meteors. They are based on the intersecting planes method developed by Ceplecha (1987), the least squares method of Borovicka (1990), and the multi-parameter fitting (MPF) method published by Gural (2012).In order to objectively compare the performances of these techniques, we have simulated realistic meteors ('fakeors') reproducing the different error measurements of many cameras networks. Some fakeors are built following the propagation models studied by Gural (2012), and others created by numerical integrations using the Borovicka et al. 2007 model. Different optimization techniques have also been investigated in order to pick the most suitable one to solve the MPF, and the influence of the geometry of the trajectory on the result is also presented.We will present here the results of an improved implementation of the multi-parameter fitting that allow an accurate orbit computation of meteors with CABERNET. The comparison of different velocities computation seems to show that if the MPF is by far the best method to solve the trajectory and the velocity of a meteor, the ill-conditioning of the costs functions used can lead to large estimate errors for noisy data.

Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish

PubMed Central

Evason, Kimberley J.; Francisco, Macrina T.; Juric, Vladislava; Balakrishnan, Sanjeev; Lopez Pazmino, Maria del Pilar; Gordan, John D.; Kakar, Sanjay; Spitsbergen, Jan; Goga, Andrei; Stainier, Didier Y. R.

2015-01-01

Hepatocellular carcinoma (HCC) is one of the most lethal human cancers. The search for targeted treatments has been hampered by the lack of relevant animal models for the genetically diverse subsets of HCC, including the 20-40% of HCCs that are defined by activating mutations in the gene encoding β-catenin. To address this chemotherapeutic challenge, we created and characterized transgenic zebrafish expressing hepatocyte-specific activated β-catenin. By 2 months post fertilization (mpf), 33% of transgenic zebrafish developed HCC in their livers, and 78% and 80% of transgenic zebrafish showed HCC at 6 and 12 mpf, respectively. As expected for a malignant process, transgenic zebrafish showed significantly decreased mean adult survival compared to non-transgenic control siblings. Using this novel transgenic model, we screened for druggable pathways that mediate β-catenin-induced liver growth and identified two c-Jun N-terminal kinase (JNK) inhibitors and two antidepressants (one tricyclic antidepressant, amitriptyline, and one selective serotonin reuptake inhibitor) that suppressed this phenotype. We further found that activated β-catenin was associated with JNK pathway hyperactivation in zebrafish and in human HCC. In zebrafish larvae, JNK inhibition decreased liver size specifically in the presence of activated β-catenin. The β-catenin-specific growth-inhibitory effect of targeting JNK was conserved in human liver cancer cells. Our other class of hits, antidepressants, has been used in patient treatment for decades, raising the exciting possibility that these drugs could potentially be repurposed for cancer treatment. In support of this proposal, we found that amitriptyline decreased tumor burden in a mouse HCC model. Our studies implicate JNK inhibitors and antidepressants as potential therapeutics for β-catenin-induced liver tumors. PMID:26134322

Dust devil vortices seen by the Mars Pathfinder camera

USGS Publications Warehouse

Metzger, S.M.; Carr, J.R.; Johnson, J. R.; Parker, T.J.; Lemmon, M.T.

1999-01-01

Discovery of dust devil vortices in Mars Pathfinder (MPF) images reveals a dust entrainment mechanism at work on Mars. Scattering of visible light by dust in the Martian atmosphere creates a pronounced haze, preventing conventional image processing from displaying dust plumes. Spectral differencing techniques have enhanced five localized dust plumes from the general haze in images acquired near midday, which we determine to be dust devils. Processing of 440 nm images highlights dust devils as distinct occultation features against the horizon. The dust devils are interpreted to be 14-79 m wide, 46-350 m tall, travel at 0.5-4.6 m/s, with dust loading of 7E-5 kg m-3, relative to the general haze of 9E-8 kg m-3, and total particulate transport of 2.2 - 700 kg. The vortices match predictions from terrestrial analog studies. Copyright 1999 by the American Geophysical Union.

MPF Top-Mast Measured Temperature

NASA Image and Video Library

1997-10-14

This temperature figure shows the change in the mean and variance of the temperature fluctuations at the Pathfinder landing site. Sol 79 and 80 are very similar, with a significant reduction of the mean and variance on Sol 81. The science team suspects that a cold front has past of the landing sight between Sols 80 and 81. http://photojournal.jpl.nasa.gov/catalog/PIA00978

Maritime Pre-Positioning Force-Future: Bill Payer or Sea Basing Enabler?

DTIC Science & Technology

2008-03-25

Ship Building Plan , UAV CLASSIFICATION: Unclassified Actions at sea no longer suffice to influence world events; actions from the sea must...in amphibious ships or fall victim to an untenable Navy ship building plan . Premature consideration of cost issues hindered MPF-F program...fiscal environment and an illusory Navy ship building plan . Given the demonstrated capability and success of the current Maritime Pre-positioning

Constraints on Martian Soil Composition as Inferred from Viking XRFS and Pathfinder APXS and IMP Data

NASA Technical Reports Server (NTRS)

Bridges, N. T.; Crisp, J. A.

2000-01-01

With the successful operation of the Alpha Proton X-Ray Spectrometer (APXS) during 1997's Mars Pathfinder (MPF) mission, geochemistry data are now available from three sites on Mars. APXS raw spectra for six soils and five rocks have been converted to compositional abundances. The Viking Lander X-Ray Fluorescence Spectrometer (XRFS) successfully measured elemental abundances of nine soils at Viking 1 and eight soils at Viking 2. Although the three landing sites are located in different parts of Mars, the soils exhibit broad similarities, with an iron-rich chemistry similar to that of palagonite. However, the Pathfinder sods show some significant differences from Viking soils, notably an enrichment in silica and depletion in sulfur. The XRFS samples consisted of near-surface and deep (up to 22 cm) soils acquired by a collector head at the cod of a retractable boom. It was possible to collect and analyze pebbles as large a 2 cm, but only sod, some in the form of consolidated clods, was sampled. In contrast, the APXS measured materials in situ. This resulted in MPF "rock" analyses that probably had a significant dust component and, as explored here, "soil" analyses that may have contained a rocky component We examine several possibilities to explain these differences and other attributes of the APXS and XRFS data sets: 1) The APXS soil measurements actually sampled a mixture of Viking-like soil and small bits of high-silica, low-sulfur rock, 2) The soils were derived from high-silica rocks mixed with a minor component of globally-homogenized dust; these soils are chemically distinct and have a separate geologic history from the Viking soils. 3) The weathering environment was different at the Pathfinder landing site compared to the Viking sites, and 4) Uncertainties in the XRFS and APXS measurements result in reported elemental abundances different than those that are actually present We show that none of the possibilities can be discounted, but that an MPF soil distinct in composition from Viking sods is best supported by the available data.

[PKA-regulated phosphorylation status of S149 and S321 sites of CDC25B inhibits mitosis of fertilized mouse eggs].

PubMed

Xiao, Jian-Ying; Liu, Chao; Sun, Xiao-Han; Yu, Bing-Zhi

2012-02-25

To further test whether protein kinase A (PKA) can affect the mitotic cell cycle, one-cell stage mouse embryos at S phase (22 h after hCG injection) were incubated in M16 medium containing various concentrations of H-89, a PKA inhibitor. With increasing concentrations of H-89 (0-50 μmol/L), the G(2) phase of eggs was decreased and the cleavage rate was accelerated. A concentration of 40 μmol/L H-89 led to all of the mouse eggs entering the M phase of mitosis. Furthermore, to study the role of PKA in regulating the phosphorylation status of S149 and S321 sites of cell division cycle 25B (CDC25B) on one-cell stage fertilized mouse eggs, pBSK-CDC25B-WT, pBSK-CDC25B-S149A, pBSK-CDC25B-S321A and pBSK-CDC25B-S149A/S321A were transcribed into mRNAs in vitro, then mRNAs were microinjected into S phase of mouse fertilized eggs and cultured in M16 medium pretreated with H-89. Then, the cleavage of fertilized eggs, maturation promoting factor (MPF) activity and phosphorylation status of CDC2-Tyr15 were observed. In the presence of 40 μmol/L H-89, the cleavage rate of fertilized eggs in CDC25B-S/A-mRNAs and CDC25B-WT-mRNA injected groups was significantly higher than that in the control groups, and the peak of MPF activity appeared in the CDC25B-S/A-mRNAs and CDC25B-WT-mRNA injected groups earlier than that in the control groups. CDC2-Tyr15 phosphorylation state was consistent with MPF activity. In conclusion, the present study suggests that PKA regulates the early development of mouse embryos by phosphorylation of S149 and S321 of CDC25B, which plays an important role in the regulation of G(2)/M transition in the mitotic cell cycle of fertilized mouse eggs.

The interrelationship between muscle oxygenation, muscle activation, and pulmonary oxygen uptake to incremental ramp exercise: influence of aerobic fitness.

PubMed

Boone, Jan; Barstow, Thomas J; Celie, Bert; Prieur, Fabrice; Bourgois, Jan

2016-01-01

We investigated whether muscle and ventilatory responses to incremental ramp exercise would be influenced by aerobic fitness status by means of a cross-sectional study with a large subject population. Sixty-four male students (age: 21.2 ± 3.2 years) with a heterogeneous peak oxygen uptake (51.9 ± 6.3 mL·min(-1)·kg(-1), range 39.7-66.2 mL·min(-1)·kg(-1)) performed an incremental ramp cycle test (20-35 W·min(-1)) to exhaustion. Breath-by-breath gas exchange was recorded, and muscle activation and oxygenation were measured with surface electromyography and near-infrared spectroscopy, respectively. The integrated electromyography (iEMG), mean power frequency (MPF), deoxygenated [hemoglobin and myoglobin] (deoxy[Hb+Mb]), and total[Hb+Mb] responses were set out as functions of work rate and fitted with a double linear function. The respiratory compensation point (RCP) was compared and correlated with the breakpoints (BPs) (as percentage of peak oxygen uptake) in muscle activation and oxygenation. The BP in total[Hb+Mb] (83.2% ± 3.0% peak oxygen uptake) preceded (P < 0.001) the BP in iEMG (86.7% ± 4.0% peak oxygen uptake) and MPF (86.3% ± 4.1% peak oxygen uptake), which in turn preceded (P < 0.01) the BP in deoxy[Hb+Mb] (88.2% ± 4.5% peak oxygen uptake) and RCP (87.4% ± 4.5% peak oxygen uptake). Furthermore, the peak oxygen uptake was significantly (P < 0.001) positively correlated to the BPs and RCP, indicating that the BPs in total[Hb+Mb] (r = 0.66; P < 0.001), deoxy[Hb+Mb] (r = 0.76; P < 0.001), iEMG (r = 0.61; P < 0.001), MPF (r = 0.63; P < 0.001), and RCP (r = 0.75; P < 0.001) occurred at a higher percentage of peak oxygen uptake in subjects with a higher peak oxygen uptake. In this study a close relationship between muscle oxygenation, activation, and pulmonary oxygen uptake was found, occurring in a cascade of events. In subjects with a higher aerobic fitness level this cascade occurred at a higher relative intensity.

Insufficient amount of Cdc2 and continuous activation of Wee1 B are the cause of meiotic failure in porcine growing oocytes.

PubMed

Nishimura, Takanori; Shimaoka, Takuma; Kano, Kiyoshi; Naito, Kunihiko

2009-10-01

In mammals, growing oocytes with a diameter less than 80% of that of full-grown oocytes cannot start meiotic maturation, and their maturation promoting factor (MPF) cannot be activated by hormonal stimulation or isolation from follicles. The aim of the present study was to identify the key molecules responsible for meiotic failure of these growing oocytes (referred to as "small oocytes" in the present study). To this end, we altered the expression of the molecules involved in MPF activation in the small oocytes of pigs by injecting them with mRNA or antisense RNA (asRNA) and examined the effects on the meiotic ability of the small oocytes. Immunoblotting analyses revealed three defects in small oocytes compared with full-grown oocytes, an inactive mitogen activated protein kinase (MAPK) cascade, a failure of cyclin B synthesis and an insufficient amount of Cdc2. Injection with mRNAs of Mos, the uppermost molecule of the MAPK cascade, cyclin B1, cyclin B2 or Cdc2 into small porcine oocytes indicated directly and for the first time that the cause of meiotic failure of porcine small oocytes is an insufficient amount of Cdc2 rather than MAPK inactivation or failure of cyclin B synthesis. Next, in order to suppress Myt1 and Wee1B, which phosphorylates at inhibitory phosphorylation sites of Cdc2 and inactive MPF, we injected their asRNAs into the porcine small oocytes and found that the Wee1B asRNA significantly increased meiotic ability, whereas the Myt1 asRNA had no effect. When Cdc2 overexpression and suppression of Wee1B expression were simultaneously induced in the small oocytes of pigs, about 70% of the small oocytes resumed meiosis, and this rate was nearly comparable with that of the full-grown oocytes. These results strongly suggest that an insufficient amount of Cdc2 and continuous activation of Wee1 B are the cause of meiotic failure of small oocytes in pigs.

An Investigation of bat durability by wood species

Treesearch

Eric Ruggiero; James Sherwood; Patrick Drane; David Kretschmann

2012-01-01

Northern white ash had been the wood of choice for Major League Baseball (MLB) bats until the introduction of hard maple in the late 1990s. Since the introduction of maple to the game, there has been a perceived increase in the rate of bats to exhibit multi-piece failures (MPF)—both ash and maple. Lab and field data indicate that while a maple bat is as...

Marine Corps Systems Command (MCSC) Advanced Planning Briefing To Industry (APBI)

DTIC Science & Technology

2008-05-14

High force protection bill associated with establishing and maintaining a secure lodgment – Ships densely packed, assemble ashore • MPF(F) – Operates...14 May 08 EXPEDITIONARY FIGHTING VEHICLE (EFV) Provide High Speed Transport of Embarked Marine Infantry From Ships Located Beyond the Horizon to...Business Size Crafting your RFI Response DO - Focus exclusively on Past Performance Provide a “Team” Brief Focus on “non-Priorities” Include

Navy-Marine Corps Amphibious and Maritime Prepositioning Ship Programs: Background and Oversight Issues for Congress

DTIC Science & Technology

2006-07-26

FY2008. Although the Navy’s proposed force of 31 amphibious ships includes 10 LPD-17 class ships, the Navy is planning to end LPD-17 procurement in...expresses concerns about the planned reduction in amphibious ships, the sea basing concept, and the MPF(F) program, and requires a report on sea basing...Ship Force Structure Plan . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 Sea Basing Concept of Operations

The kinematic history of the Khlong Marui and Ranong Faults, southern Thailand

NASA Astrophysics Data System (ADS)

Watkinson, Ian; Elders, Chris; Hall, Robert

2008-12-01

The Khlong Marui Fault (KMF) and Ranong Fault (RF) are major NNE-trending strike-slip faults which dissect peninsular Thailand. They have been assumed to be conjugate to the NW-trending Three Pagodas Fault (TPF) and Mae Ping Fault (MPF) in Northern Thailand, which experienced a diachronous reversal in shear sense during India-Eurasia collision. It follows that the KMF and RF are expected to show the opposite shear sense and a slip sense reversal at a similar time to the TPF and MPF. New field data from the KMF and RF reveal two phases of ductile dextral shear separated by Campanian magmatism. Paleocene to Eocene post-kinematic granites date the end of this phase, while a brittle sinistral phase deforms the granites, and has exhumed the ductile fault rocks. The timing of these movements precludes formation of the faults in response to Himalayan extrusion tectonics. Instead, they formed near the southern margin of a Late Cretaceous-Paleocene orogen, and may have been influenced by variations in the rate of subduction ahead of India and Australia. North-south compression prior to reactivation of the subduction zone around southern Sundaland in the Eocene caused widespread deformation in the over-riding plate, including sinistral transpression on the KMF and RF.

Locus of frequency-dependent depression identified with multiple-probability fluctuation analysis at rat climbing fibre-Purkinje cell synapses

PubMed Central

Silver, R Angus; Momiyama, Akiko; Cull-Candy, Stuart G

1998-01-01

EPSCs were recorded under whole-cell voltage clamp at room temperature from Purkinje cells in slices of cerebellum from 12- to 14-day-old rats. EPSCs from individual climbing fibre (CF) inputs were identified on the basis of their large size, paired-pulse depression and all-or-none appearance in response to a graded stimulus. Synaptic transmission was investigated over a wide range of experimentally imposed release probabilities by analysing fluctuations in the peak of the EPSC. Release probability was manipulated by altering the extracellular [Ca2+] and [Mg2+]. Quantal parameters were estimated from plots of coefficient of variation (CV) or variance against mean conductance by fitting a multinomial model that incorporated both spatial variation in quantal size and non-uniform release probability. This ‘multiple-probability fluctuation’ (MPF) analysis gave an estimate of 510 ± 50 for the number of functional release sites (N) and a quantal size (q) of 0.5 ± 0.03 nS (n = 6). Control experiments, and simulations examining the effects of non-uniform release probability, indicate that MPF analysis provides a reliable estimate of quantal parameters. Direct measurement of quantal amplitudes in the presence of 5 mm Sr2+, which gave asynchronous release, yielded distributions with a mean quantal size of 0.55 ± 0.01 nS and a CV of 0.37 ± 0.01 (n = 4). Similar estimates of q were obtained in 2 mm Ca2+ when release probability was lowered with the calcium channel blocker Cd2+. The non-NMDA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX; 1 μm) reduced both the evoked current and the quantal size (estimated with MPF analysis) to a similar degree, but did not affect the estimate of N. We used MPF analysis to identify those quantal parameters that change during frequency-dependent depression at climbing fibre-Purkinje cell synaptic connections. At low stimulation frequencies, the mean release probability (P¯r) was unusually high (0.90 ± 0.03 at 0.033 Hz, n = 5), but as the frequency of stimulation was increased, pr fell dramatically (0.02 ± 0.01 at 10 Hz, n = 4) with no apparent change in either q or N. This indicates that the observed 50-fold depression in EPSC amplitude is presynaptic in origin. Presynaptic frequency-dependent depression was investigated with double-pulse and multiple-pulse protocols. EPSC recovery, following simultaneous release at practically all sites, was slow, being well fitted by the sum of two exponential functions (time constants of 0.35 ± 0.09 and 3.2 ± 0.4 s, n = 5). EPSC recovery following sustained stimulation was even slower. We propose that presynaptic depression at CF synapses reflects a slow recovery of release probability following release of each quantum of transmitter. The large number of functional release sites, relatively large quantal size, and unusual dynamics of transmitter release at the CF synapse appear specialized to ensure highly reliable olivocerebellar transmission at low frequencies but to limit transmission at higher frequencies. PMID:9660900

Navy LPD-17 Amphibious Ship Procurement: Background, Issues, and Options for Congress

DTIC Science & Technology

2008-10-01

planned 313-ship fleet calls for a 31-ship amphibious force that includes 10 LPD-17s, and the Marine Corps states that a 33-ship amphibious force that...state, reflects responsibilities assigned to Marine Corps forces in U.S. regional war plans . The Navy’s FY2009 30-year (FY2009-FY2038) shipbuilding plan ...13 Service Life Extensions for Amphibious Ships . . . . . . . . . . . . . . . . . . 13 Planned MPF(F) Squadron

Cell cycle in ascidian eggs and embryos.

PubMed

McDougall, Alex; Chenevert, Janet; Lee, Karen W; Hebras, Celine; Dumollard, Remi

2011-01-01

In ascidians the cell cycle machinery has been studied mainly in oocytes while ascidian embryos have been used to dissect the mechanism that controls asymmetric cell division (ACD). Here we overview the most specific and often exceptional points and events in cell cycle control in ascidian oocytes and early embryos. Mature stage IV eggs are arrested at metaphase I due to cytostatic factor (CSF). In vertebrates, unfertilized eggs are arrested at metaphase II by CSF. Meta II-CSF is mediated by the Mos/MEK/MAPK/Erp1 pathway, which inhibits the ubiquitin ligase APC/C(cdc20) preventing cyclin B destruction thus stabilizing MPF activity. CSF is inactivated by the fertilization Ca(2+) transient that stimulates the destruction of Erp1 thus releasing APC/C(cdc20) from inhibition. Although many of the components of CSF are conserved between the ascidian and the vertebrates, the lack of Erp1 in the ascidians (and indeed other invertebrates) is notable since the Mos/MAPK pathway nonetheless mediates Meta I-CSF. Moreover, since the fertilization Ca(2+) transient targets Erp1, it is not clear how the sperm-triggered Ca(2+) transient in ascidians (and again other invertebrates) stimulates cyclin B destruction in the absence of Erp1. Nonetheless, like mammalian eggs, sperm trigger a series of Ca(2+) oscillations that increases the rate of cyclin B destruction and the subsequent loss of MAPK activity leading to meiotic exit in ascidians. Positive feedback from MPF maintains the Ca(2+) oscillations in fertilized ascidian eggs ensuring the eventual loss of MPF stimulating the egg-to-embryo transition. Embryonic cell cycles in the ascidian are highly stereotyped where both the rate of cell division and the orientation of cell division planes are precisely controlled. Three successive rounds of ACD generate two small posterior germ cell precursors at the 64 cell stage. The centrosome-attracting body (CAB) is a macroscopic cortical structure visible by light microscopy that causes these three rounds of ACD. Entry into mitosis activates the CAB causing the whole mitotic spindle to rotate and migrate toward the cortical CAB leading to a highly ACD whereby one small cell is formed that inherits the CAB and approximately 40 maternal postplasmic/PEM RNAs including the germ cell marker vasa.

A CBO Study. Sea Basing and Alternatives for Deploying and Sustaining Ground Combat Forces

DTIC Science & Technology

2007-07-01

ships in the planned MPF(F) will not be large enough to receive aircraft capable of delivering cargo over intercontinental ranges. A high - speed ... speed roll-on/roll-off ship (top) and an intratheater high - speed vessel (bottom) are shown alongside a notional mobile landing platform (center) with...might be needed to fully support sea-based ground forces. Those other ships could include tankers and high - speed ships for spe- cial

Navy Force Structure and Shipbuilding Plans: Background and Issues for Congress

DTIC Science & Technology

2006-08-14

number. 1. REPORT DATE 14 AUG 2006 2. REPORT TYPE 3. DATES COVERED 00-00-2006 to 00-00-2006 4. TITLE AND SUBTITLE Navy Force Structure and...ES) 10. SPONSOR/MONITOR’S ACRONYM(S) 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 12. DISTRIBUTION/ AVAILABILITY STATEMENT Approved for public release...MPF(F), squadron with 12 new-construction amphibious and sealift- type ships. In conjunction with this proposed 313-ship fleet, the Navy submitted a

The signaling pathways by which the Fas/FasL system accelerates oocyte aging.

PubMed

Zhu, Jiang; Lin, Fei-Hu; Zhang, Jie; Lin, Juan; Li, Hong; Li, You-Wei; Tan, Xiu-Wen; Tan, Jing-He

2016-02-01

In spite of great efforts, the mechanisms for postovulatory oocyte aging are not fully understood. Although our previous work showed that the FasL/Fas signaling facilitated oocyte aging, the intra-oocyte signaling pathways are unknown. Furthermore, the mechanisms by which oxidative stress facilitates oocyte aging and the causal relationship between Ca2+ rises and caspase-3 activation and between the cell cycle and apoptosis during oocyte aging need detailed investigations. Our aim was to address these issues by studying the intra-oocyte signaling pathways for Fas/FasL to accelerate oocyte aging. The results indicated that sFasL released by cumulus cells activated Fas on the oocyte by increasing reactive oxygen species via activating NADPH oxidase. The activated Fas triggered Ca2+ release from the endoplasmic reticulum by activating phospholipase C-γ pathway and cytochrome c pathway. The cytoplasmic Ca2+ rises activated calcium/calmodulin-dependent protein kinase II (CaMKII) and caspase-3. While activated CaMKII increased oocyte susceptibility to activation by inactivating maturation-promoting factor (MPF) through cyclin B degradation, the activated caspase-3 facilitated further Ca2+releasing that activates more caspase-3 leading to oocyte fragmentation. Furthermore, caspase-3 activation and fragmentation were prevented in oocytes with a high MPF activity, suggesting that an oocyte must be in interphase to undergo apoptosis.

Upper Limb Muscle and Brain Activity in Light Assembly Task on Different Load Levels

NASA Astrophysics Data System (ADS)

Zadry, Hilma Raimona; Dawal, Siti Zawiah Md.; Taha, Zahari

2010-10-01

A study was conducted to investigate the effect of load on upper limb muscles and brain activities in light assembly task. The task was conducted at two levels of load (Low and high). Surface electromyography (EMG) was used to measure upper limb muscle activities of twenty subjects. Electroencephalography (EEG) was simultaneously recorded with EMG to record brain activities from Fz, Pz, O1 and O2 channels. The EMG Mean Power Frequency (MPF) of the right brachioradialis and the left upper trapezius activities were higher on the high-load task compared to low-load task. The EMG MPF values also decrease as time increases, that reflects muscle fatigue. Mean power of the EEG alpha bands for the Fz-Pz channels were found to be higher on the high-load task compared to low-load task, while for the O1-O2 channels, they were higher on the low-load task than on the high-load task. These results indicated that the load levels effect the upper limb muscle and brain activities. The high-load task will increase muscle activities on the right brachioradialis and the left upper tapezius muscles, and will increase the awareness and motivation of the subjects. Whilst the low-load task can generate drowsiness earlier. It signified that the longer the time and the more heavy of the task, the subjects will be more fatigue physically and mentally.

Numerical experiments on neutron yield and soft x-ray study of a ˜100 kJ plasma focus using the current profile fitting technique

NASA Astrophysics Data System (ADS)

Ong, S. T.; Chaudhary, K.; Ali, J.; Lee, S.

2014-07-01

Numerical experiments using the Lee model were performed to study the neutron yield and soft x-ray emission from the IR-MPF-100 plasma focus using the current fitting technique. The mass sweeping factor and the current factor for the axial and radial phase were used to represent the imperfections encountered in experiments. All gross properties including the yields were realistically simulated once the computed and measured current profiles were well fitted. The computed neutron yield Yn was in agreement with the experimentally measured Yn at 20 kV (E0 ˜ 30 kJ) charging voltage. The optimum computed neutron yield of Yn = 1.238 × 109 neutrons per shot was obtained at optimum physics parameters of the plasma focus operated with deuterium gas. It was also observed that no soft x-rays were emitted from the IR-MPF-100 plasma focus operated with argon gas due to the absence of helium-like and hydrogen-like ions at a low plasma temperature (˜0.094 keV) and axial speed (8.12 cm µs-1). However, the soft x-ray yield can be achieved by increasing the charging voltage, using a higher ratio of outer anode radius to inner anode radius c or shorter anode length z0, or using neon as the operating gas.

Building on the EGIPPS performance assessment: the multipolar framework as a heuristic to tackle the complexity of performance of public service oriented health care organisations.

PubMed

Marchal, Bruno; Hoerée, Tom; da Silveira, Valéria Campos; Van Belle, Sara; Prashanth, Nuggehalli S; Kegels, Guy

2014-04-17

Performance of health care systems is a key concern of policy makers and health service managers all over the world. It is also a major challenge, given its multidimensional nature that easily leads to conceptual and methodological confusion. This is reflected by a scarcity of models that comprehensively analyse health system performance. In health, one of the most comprehensive performance frameworks was developed by the team of Leggat and Sicotte. Their framework integrates 4 key organisational functions (goal attainment, production, adaptation to the environment, and values and culture) and the tensions between these functions.We modified this framework to better fit the assessment of the performance of health organisations in the public service domain and propose an analytical strategy that takes it into the social complexity of health organisations. The resulting multipolar performance framework (MPF) is a meta-framework that facilitates the analysis of the relations and interactions between the multiple actors that influence the performance of health organisations. Using the MPF in a dynamic reiterative mode not only helps managers to identify the bottlenecks that hamper performance, but also the unintended effects and feedback loops that emerge. Similarly, it helps policymakers and programme managers at central level to better anticipate the potential results and side effects of and required conditions for health policies and programmes and to steer their implementation accordingly.

Navy LPD-17 Amphibious Ship Procurement: Background, Issues, and Options for Congress

DTIC Science & Technology

2008-05-06

planned 313-ship fleet calls for a 31-ship amphibious force that includes 10 LPD-17s, and the Marine Corps states that a 33-ship amphibious force that...reflects responsibilities assigned to Marine Corps forces in U.S. regional war plans . The Navy’s FY2009 30-year (FY2009-FY2038) shipbuilding plan , if...extensions for existing amphibious ships, whether all the ships in the planned complementary Maritime Prepositionning Force of the Future (MPF[F

Intracellular and Extracellular pH and Ca Are Bound to Control Mitosis in the Early Sea Urchin Embryo via ERK and MPF Activities

PubMed Central

Ciapa, Brigitte; Philippe, Laetitia

2013-01-01

Studies aiming to predict the impact on marine life of ocean acidification and of altered salinity have shown altered development in various species including sea urchins. We have analyzed how external Na, Ca, pH and bicarbonate control the first mitotic divisions of sea urchin embryos. Intracellular free Ca (Cai) and pH (pHi) and the activities of the MAP kinase ERK and of MPF regulate mitosis in various types of cells including oocytes and early embryos. We found that intracellular acidification of fertilized eggs by Na-acetate induces a huge activation of ERK at time of mitosis. This also stops the cell cycle and leads to cell death, which can be bypassed by treatment with the MEK inhibitor U0126. Similar intracellular acidification induced in external medium containing low sodium or 5-(N-Methyl-N-isobutyl) amiloride, an inhibitor of the Na+/H+ exchanger, also stops the cell cycle and leads to cell death. In that case, an increase in Cai and in the phosphorylation of tyr-cdc2 occurs during mitosis, modifications that depend on external Ca. Our results indicate that the levels of pHi and Cai determine accurate levels of Ptyr-Cdc2 and P-ERK capable of ensuring progression through the first mitotic cycles. These intracellular parameters rely on external Ca, Na and bicarbonate, alterations of which during climate changes could act synergistically to perturb the early marine life. PMID:23785474

Intracellular and extracellular pH and Ca are bound to control mitosis in the early sea urchin embryo via ERK and MPF activities.

PubMed

Ciapa, Brigitte; Philippe, Laetitia

2013-01-01

Studies aiming to predict the impact on marine life of ocean acidification and of altered salinity have shown altered development in various species including sea urchins. We have analyzed how external Na, Ca, pH and bicarbonate control the first mitotic divisions of sea urchin embryos. Intracellular free Ca (Cai) and pH (pHi) and the activities of the MAP kinase ERK and of MPF regulate mitosis in various types of cells including oocytes and early embryos. We found that intracellular acidification of fertilized eggs by Na-acetate induces a huge activation of ERK at time of mitosis. This also stops the cell cycle and leads to cell death, which can be bypassed by treatment with the MEK inhibitor U0126. Similar intracellular acidification induced in external medium containing low sodium or 5-(N-Methyl-N-isobutyl) amiloride, an inhibitor of the Na(+)/H(+) exchanger, also stops the cell cycle and leads to cell death. In that case, an increase in Cai and in the phosphorylation of tyr-cdc2 occurs during mitosis, modifications that depend on external Ca. Our results indicate that the levels of pHi and Cai determine accurate levels of Ptyr-Cdc2 and P-ERK capable of ensuring progression through the first mitotic cycles. These intracellular parameters rely on external Ca, Na and bicarbonate, alterations of which during climate changes could act synergistically to perturb the early marine life.

Building on the EGIPPS performance assessment: the multipolar framework as a heuristic to tackle the complexity of performance of public service oriented health care organisations

PubMed Central

2014-01-01

Background Performance of health care systems is a key concern of policy makers and health service managers all over the world. It is also a major challenge, given its multidimensional nature that easily leads to conceptual and methodological confusion. This is reflected by a scarcity of models that comprehensively analyse health system performance. Discussion In health, one of the most comprehensive performance frameworks was developed by the team of Leggat and Sicotte. Their framework integrates 4 key organisational functions (goal attainment, production, adaptation to the environment, and values and culture) and the tensions between these functions. We modified this framework to better fit the assessment of the performance of health organisations in the public service domain and propose an analytical strategy that takes it into the social complexity of health organisations. The resulting multipolar performance framework (MPF) is a meta-framework that facilitates the analysis of the relations and interactions between the multiple actors that influence the performance of health organisations. Summary Using the MPF in a dynamic reiterative mode not only helps managers to identify the bottlenecks that hamper performance, but also the unintended effects and feedback loops that emerge. Similarly, it helps policymakers and programme managers at central level to better anticipate the potential results and side effects of and required conditions for health policies and programmes and to steer their implementation accordingly. PMID:24742181

Entry descent and landing systems for small planetary missions: Parametric comparison of parachutes and inflatable systems for the proposed Vanguard Mars mission

NASA Astrophysics Data System (ADS)

Allouis, E.; Ellery, A.; Welch, C. S.

2006-10-01

Here, the feasibility of a post-Beagle2 robotic Mars mission of modest size, mass and cost with a high scientific return is assessed. Based on a triad of robotics comprising a lander, a rover and three penetrating moles, the mission is astrobiology focussed, but also provides a platform for technology demonstration. The study is investigating two Entry, Descent and Landing Systems (EDLS) for the 120 kg—mission based on the conventional heatshield/parachute duo and on the use of inflatable technologies as demonstrated by the IRDT/IRDT2 projects. Moreover, to make use of existing aerodynamic databases, both EDLS are considered with two geometries: the Mars pathfinder (MPF) and Huygens/Beagle2 (B2) configurations. A versatile EDL model has been developed to provide a preliminary sizing for the different EDL systems such as heatshield, parachute, and inflatables for small to medium planetary missions. With a landed mass of 65 kg, a preliminary mass is derived for each system of the mission to provide a terminal velocity compatible with the use of airbags. On both conventional and inflatable options, the MPF configuration performs slightly better mass-wise since its cone half-angle is flatter at 70. Overall, the inflatable braking device (IBD) option performs better than the conventional one and would provide in this particular case a decrease in mass of the EDLS of about 15 18% that can be redistributed to the payload.

Entry Descent and Landing Systems for small planetary missions: parametric comparison of parachutes and inflatable systems for the proposed Vanguard Mars mission

NASA Astrophysics Data System (ADS)

Allouis, E.; Ellery, A.; Welch, C. S.

2003-11-01

Here the feasibility of a post-Beagle2 robotic Mars mission of modest size, mass and cost with a high scientific return is assessed. Based on a triad of robotics comprising a lander, a rover and three penetrating moles, the mission is astrobiology focussed, but also provides a platform for technology demonstration. The study is investigating two Entry, Descent and Landing Systems (EDLS) for the 120kg - mission based on the conventional heatshield/parachute duo and on the use of inflatable technologies as demonstrated by the IRDT/IRDT2 projects. Moreover, to make use of existing aerodynamic databases, both EDLS are considered with two geometries: the Mars Pathfinder (MPF) and Huygens/Beagle2 (B2) configurations. A versatile EDL model has been developed to provide a preliminary sizing for the different EDL systems such as heatshield, parachute, and inflatables for small to medium planetary missions. With a landed mass of 65 kg, a preliminary mass is derived for each system of the mission to provide a terminal velocity compatible with the use of airbags. On both conventional and inflatable options, the MPF configuration performs slightly better mass-wise since its cone half-angle is flatter at 70 degrees. Overall, the Inflatable Braking Device (IBD) option performs better than the conventional one and would provide in this particular case a decrease in mass of the EDLS of about 15-18% that can be redistributed to the payload.

Isokinetic and Electromyographic Properties of Muscular Endurance in Short and Long-Term Type 2 Diabetes

PubMed Central

Hatef, Boshra; Ghanjal, Ali; Meftahi, Gholam Hossein; Askary-Ashtiani, Ahmadreza

2016-01-01

Background: Patients with type 2 diabetes mellitus (T2DM) are subject to progressive reduction of muscle mass and strength. The aim of this study was to assess muscle forces and electromyography (EMG) indices in short and long-term diabetes during an isokinetic exercise. Methods: The peak torque, work, mean power frequency (MPF) and root mean square (RMS) of knee flexors and extensors during 40 isokinetic knee extension-flexion repetitions with a velocity of 150 degree/s were recorded. 18 patients with less than 10 years with T2DM and 12 patients with equal and more than 10 years of disease were compared with 20 gender, body mass index, physical activity and peripheral circulation matched healthy controls. Results: The fatigue index and slope of line across the peak torque values of the knee flexor indicate that patients with long-term T2DM were significantly more resistant to fatigue in comparison with the two other groups (p<0.009). Whereas the MPF decrease during isokinetic protocol interact with grouping in the medial hamstring (p<0.042), but it was independent to groups in other muscles (p<0.0001). The increase of RMS after fatigue protocol interacted with sex for the medial hamstring and vastus lateralis (p<0.039) and interacted with group for the extensor muscles (p<0.045). Discussion & Conclusion: It seems that long-term T2DM cause some neuromuscular adaptations to maintain knee flexor muscle performance during functional activity especially postural control. PMID:27045412

Sport-specific functional movement can simulate aspects of neuromuscular fatigue occurring in team sports.

PubMed

Wilke, Jan; Fleckenstein, Johannes; Krause, Frieder; Vogt, Lutz; Banzer, Winfried

2016-06-01

Fatigue protocols have been used over the years to examine muscular exhaustion. As an alternative to approaches in laboratory settings, functional agility protocols claiming to mimic the multifaceted loads of athletic activity have been proposed. This study aimed to examine the effects of a functional agility short-term fatigue protocol (FAST-FP) on neuromuscular function. Twenty-eight healthy sports students (15 males, aged 24.3 ± 2.4 years) completed the FAST-FP, which consists of four components: three counter-movement jumps (90% of individual maximum), a 20-s bout of step-ups, three bodyweight squats and an agility run. Tasks were repeated until the participants no longer achieved the required jump height in two consecutive sets. Outcomes (pre-post) encompassed subjective exhaustion (visual analogue scale [VAS]), maximum isometric voluntary force of the knee extensors (MIVF), reactive strength index (RSI), mean power frequency (MPF, measured using surface electromyography) and maximum knee range of motion (ROM). Post-intervention, VAS (+54 mm) increased significantly, while MIVF (-6.1%), RSI (-10.7%) and MPF (-4.1%) were reduced (p < 0.05). No changes were observed for ROM (p > 0.05). The FAST-FP induces small-to-moderate impairments in neuromuscular function and considerable self-perceived fatigue. Current evidence on exhaustion developing in team sports suggests that this magnitude of fatigue is similar. The protocol might thus be valuable in the evaluation of treatments counteracting post-match fatigue in team sports.

Relationship between oxygen uptake slow component and surface EMG during heavy exercise in humans: influence of pedal rate.

PubMed

Vercruyssen, Fabrice; Missenard, Olivier; Brisswalter, Jeanick

2009-08-01

The aim of this study was to test the hypothesis that extreme pedal rates contributed to the slow component of oxygen uptake (VO(2) SC) in association with changes in surface electromyographic (sEMG) during heavy-cycle exercise. Eight male trained cyclists performed two square-wave transitions at 50 and 110 rpm at a work rate that would elicit a VO(2) corresponding to 50% of the difference between peak VO(2) and the ventilatory threshold. Pulmonary gas exchange was measured breath-by-breath and sEMG was obtained from the vastus lateralis and medialis muscles. Integrated EMG flow (QiEMG) and mean power frequency (MPF) were computed. The relative amplitude of the VO(2) SC was significantly higher during the 110-rpm bout (556+/-186 ml min(-1), P<0.05) with compared to the 50-rpm bout (372+/-227 ml min(-1)). QiEMG values increased throughout exercise only during the 110-rpm bout and were associated with the greater amplitude of the VO(2) SC observed for this condition (P<0.05). MPF values remained relatively constant whatever the cycle bout. These findings indicated a VO(2) SC at the two pedal rates but the association with sEMG responses was observed only at high pedal rate. Possible changes in motor units recruitment pattern, muscle energy turnover and muscle temperature have been suggested to explain the different VO(2) SC to heavy pedal rate bouts.

Amphiphilic cationic peptides mediate cell adhesion to plastic surfaces.

PubMed

Rideout, D C; Lambert, M; Kendall, D A; Moe, G R; Osterman, D G; Tao, H P; Weinstein, I B; Kaiser, E T

1985-09-01

Four amphiphilic peptides, each with net charges of +2 or more at neutrality and molecular weights under 4 kilodaltons, were found to mediate the adhesion of normal rat kidney fibroblasts to polystyrene surfaces. Two of these peptides, a model for calcitonin (peptide 1, MCT) and melittin (peptide 2, MEL), form amphiphilic alpha-helical structures at aqueous/nonpolar interfaces. The other two, a luteinizing hormone-releasing hormone model (peptide 3, LHM) and a platelet factor model (peptide 4, MPF) form beta-strand structures in amphiphilic environments. Although it contains only 10 residues, LHM mediated adhesion to surfaces coated with solutions containing as little as 10 pmoles/ml of peptide. All four of these peptides were capable of forming monolayers at air-buffer interfaces with collapse pressures greater than 20 dynes/cm. None of these four peptides contains the tetrapeptide sequence Arg-Gly-Asp-Ser, which has been associated with fibronectin-mediated cell adhesion. Ten polypeptides that also lacked the sequence Arg-Gly-Asp-Ser but were nonamphiphilic and/or had net charges less than +2 at neutrality were all incapable of mediating cell adhesion (Pierschbacher and Ruoslahti, 1984). The morphologies of NRK cells spread on polystyrene coated with peptide LHM resemble the morphologies on fibronectin-coated surfaces, whereas cells spread on surfaces coated with MCT or MEL exhibit strikingly different morphologies. The adhesiveness of MCT, MEL, LHM, and MPF implies that many amphiphilic cationic peptides could prove useful as well defined adhesive substrata for cell culture and for studies of the mechanism of cell adhesion.

Length scale effects and multiscale modeling of thermally induced phase transformation kinetics in NiTi SMA

NASA Astrophysics Data System (ADS)

Frantziskonis, George N.; Gur, Sourav

2017-06-01

Thermally induced phase transformation in NiTi shape memory alloys (SMAs) shows strong size and shape, collectively termed length scale effects, at the nano to micrometer scales, and that has important implications for the design and use of devices and structures at such scales. This paper, based on a recently developed multiscale model that utilizes molecular dynamics (MDs) simulations at small scales and MD-verified phase field (PhF) simulations at larger scales, reports results on specific length scale effects, i.e. length scale effects in martensite phase fraction (MPF) evolution, transformation temperatures (martensite and austenite start and finish) and in the thermally cyclic transformation between austenitic and martensitic phase. The multiscale study identifies saturation points for length scale effects and studies, for the first time, the length scale effect on the kinetics (i.e. developed internal strains) in the B19‧ phase during phase transformation. The major part of the work addresses small scale single crystals in specific orientations. However, the multiscale method is used in a unique and novel way to indirectly study length scale and grain size effects on evolution kinetics in polycrystalline NiTi, and to compare the simulation results to experiments. The interplay of the grain size and the length scale effect on the thermally induced MPF evolution is also shown in this present study. Finally, the multiscale coupling results are employed to improve phenomenological material models for NiTi SMA.

Validity and Reliability of Gait and Postural Control Analysis Using the Tri-axial Accelerometer of the iPod Touch.

PubMed

Kosse, Nienke M; Caljouw, Simone; Vervoort, Danique; Vuillerme, Nicolas; Lamoth, Claudine J C

2015-08-01

Accelerometer-based assessments can identify elderly with an increased fall risk and monitor interventions. Smart devices, like the iPod Touch, with built-in accelerometers are promising for clinical gait and posture assessments due to easy use and cost-effectiveness. The aim of the present study was to establish the validity and reliability of the iPod Touch for gait and posture assessment. Sixty healthy participants (aged 18-75 years) were measured with an iPod Touch and stand-alone accelerometer while they walked under single- and dual-task conditions, and while standing in parallel and semi-tandem stance with eyes open, eyes closed and when performing a dual task. Cross-correlation values (CCV) showed high correspondence of anterior-posterior and medio-lateral signal patterns (CCV's ≥ 0.88). Validity of gait parameters (foot contacts, index of harmonicity, and amplitude variability) and standing posture parameters [root mean square of accelerations, median power frequency (MPF) and sway area] as indicated by intra-class correlation (ICC) was high (ICC = 0.85-0.99) and test-retest reliability was good (ICC = 0.81-0.97), except for MPF (ICC = 0.59-0.87). Overall, the iPod Touch obtained valid and reliable measures of gait and postural control in healthy adults of all ages under different conditions. Additionally, smart devices have the potential to be used for clinical gait and posture assessments.

Task Failure during Exercise to Exhaustion in Normoxia and Hypoxia Is Due to Reduced Muscle Activation Caused by Central Mechanisms While Muscle Metaboreflex Does Not Limit Performance

PubMed Central

Torres-Peralta, Rafael; Morales-Alamo, David; González-Izal, Miriam; Losa-Reyna, José; Pérez-Suárez, Ismael; Izquierdo, Mikel; Calbet, José A. L.

2016-01-01

To determine whether task failure during incremental exercise to exhaustion (IE) is principally due to reduced neural drive and increased metaboreflex activation eleven men (22 ± 2 years) performed a 10 s control isokinetic sprint (IS; 80 rpm) after a short warm-up. This was immediately followed by an IE in normoxia (Nx, PIO2:143 mmHg) and hypoxia (Hyp, PIO2:73 mmHg) in random order, separated by a 120 min resting period. At exhaustion, the circulation of both legs was occluded instantaneously (300 mmHg) during 10 or 60 s to impede recovery and increase metaboreflex activation. This was immediately followed by an IS with open circulation. Electromyographic recordings were obtained from the vastus medialis and lateralis. Muscle biopsies and blood gases were obtained in separate experiments. During the last 10 s of the IE, pulmonary ventilation, VO2, power output and muscle activation were lower in hypoxia than in normoxia, while pedaling rate was similar. Compared to the control sprint, performance (IS-Wpeak) was reduced to a greater extent after the IE-Nx (11% lower P < 0.05) than IE-Hyp. The root mean square (EMGRMS) was reduced by 38 and 27% during IS performed after IE-Nx and IE-Hyp, respectively (Nx vs. Hyp: P < 0.05). Post-ischemia IS-EMGRMS values were higher than during the last 10 s of IE. Sprint exercise mean (IS-MPF) and median (IS-MdPF) power frequencies, and burst duration, were more reduced after IE-Nx than IE-Hyp (P < 0.05). Despite increased muscle lactate accumulation, acidification, and metaboreflex activation from 10 to 60 s of ischemia, IS-Wmean (+23%) and burst duration (+10%) increased, while IS-EMGRMS decreased (−24%, P < 0.05), with IS-MPF and IS-MdPF remaining unchanged. In conclusion, close to task failure, muscle activation is lower in hypoxia than in normoxia. Task failure is predominantly caused by central mechanisms, which recover to great extent within 1 min even when the legs remain ischemic. There is dissociation between the recovery of EMGRMS and performance. The reduction of surface electromyogram MPF, MdPF and burst duration due to fatigue is associated but not caused by muscle acidification and lactate accumulation. Despite metaboreflex stimulation, muscle activation and power output recovers partly in ischemia indicating that metaboreflex activation has a minor impact on sprint performance. PMID:26793117

A New Strategy for ECG Baseline Wander Elimination Using Empirical Mode Decomposition

NASA Astrophysics Data System (ADS)

Shahbakhti, Mohammad; Bagheri, Hamed; Shekarchi, Babak; Mohammadi, Somayeh; Naji, Mohsen

2016-06-01

Electrocardiogram (ECG) signals might be affected by various artifacts and noises that have biological and external sources. Baseline wander (BW) is a low-frequency artifact that may be caused by breathing, body movements and loose sensor contact. In this paper, a novel method based on empirical mode decomposition (EMD) for removal of baseline noise from ECG is presented. When compared to other EMD-based methods, the novelty of this research is to reach the optimized number of decomposed levels for ECG BW de-noising using mean power frequency (MPF), while the reduction of processing time is considered. To evaluate the performance of the proposed method, a fifth-order Butterworth high pass filtering (BHPF) with cut-off frequency at 0.5Hz and wavelet approach are applied. Three performance indices, signal-to-noise ratio (SNR), mean square error (MSE) and correlation coefficient (CC), between pure and filtered signals have been utilized for qualification of presented techniques. Results suggest that the EMD-based method outperforms the other filtering method.

Precipitation Organization in a Warmer Climate

NASA Astrophysics Data System (ADS)

Rickenbach, T. M.; Nieto Ferreira, R.; Nissenbaum, M.

2014-12-01

This study will investigate changes in precipitation organization in a warmer climate using the Weather Research and Forecasting (WRF) model and CMIP-5 ensemble climate simulations. This work builds from an existing four-year NEXRAD radar-based precipitation climatology over the southeastern U.S. that uses a simple two-category framework of precipitation organization based on instantaneous precipitating feature size. The first category - mesoscale precipitation features (MPF) - dominates winter precipitation and is linked to the more predictable large-scale forcing provided by the extratropical cyclones. In contrast, the second category - isolated precipitation - dominates the summer season precipitation in the southern coastal and inland regions but is linked to less predictable mesoscale circulations and to local thermodynamics more crudely represented in climate models. Most climate modeling studies suggest that an accelerated water cycle in a warmer world will lead to an overall increase in precipitation, but few studies have addressed how precipitation organization may change regionally. To address this, WRF will simulate representative wintertime and summertime precipitation events in the Southeast US under the current and future climate. These events will be simulated in an environment resembling the future climate of the 2090s using the pseudo-global warming (PGW) approach based on an ensemble of temperature projections. The working hypothesis is that the higher water vapor content in the future simulation will result in an increase in the number of isolated convective systems, while MPFs will be more intense and longer-lasting. In the context of the seasonal climatology of MPF and isolated precipitation, these results have implications for assessing the predictability of future regional precipitation in the southeastern U.S.

Induction of diploid gynogenesis in an evolutionary model organism, the three-spined stickleback (Gasterosteus aculeatus)

PubMed Central

2011-01-01

Background Rapid advances in genomics have provided nearly complete genome sequences for many different species. However, no matter how the sequencing technology has improved, natural genetic polymorphism complicates the production of high quality reference genomes. To address this problem, researchers have tried using artificial modes of genome manipulation such as gynogenesis for fast production of inbred lines. Results Here, we present the first successful induction of diploid gynogenesis in an evolutionary model system, the three-spined sticklebacks (Gasterosteus aculeatus), using a combination of UV-irradiation of the sperm and heat shock (HS) of the resulting embryo to inhibit the second meiotic division. Optimal UV irradiation of the sperm was established by exposing stickleback sperm to a UV- light source at various times. Heat shock parameters like temperature, duration, and time of initiation were tested by subjecting eggs fertilized with UV inactivated sperm 5, 10, 15, 20, 25, or 30 minutes post fertilization (mpf) to 30°C, 34°C, or 38°C for 2, 4, 6 or 8 minutes. Gynogen yield was highest when stickleback eggs were activated with 2 minutes UV-irradiated sperm and received HS 5 mpf at 34°C for 4 minutes. Conclusions Diploid gynogenesis has been successfully performed in three-spined stickleback. This has been confirmed by microsatellite DNA analysis which revealed exclusively maternal inheritance in all gynogenetic fry tested. Ploidy verification by flow cytometry showed that gynogenetic embryos/larvae exhibiting abnormalities were haploids and those that developed normally were diploids, i.e., double haploids that can be raised until adult size. PMID:21910888

Sea Basing Platforms for the 21st Century - An Evaluation of Maritime Prepositioning Force (Future) [MPF(F)] and the Mobile Offshore Base (MOB) to Perform Sea Basing

DTIC Science & Technology

2004-01-01

Large, Medium Speed , Roll-On/Roll-Off (LMSR) ships . The BLA sea base ships share a common hull, a common propulsion plant, and internal design from...would have the propulsion capable of maintaining a speed of 25 knots. Cargo fuel is stored in either the centerline tanks or in the deep tanks in the...for the Marine Expeditionary Force (Forward) [MEF(FWD)]. The ships required a seaport to offload cargo , an airfield to be the aerial port of

Winter Severe Weather: A Case Study of the Intense Squall Line of 6-7 January 1995 in the Carolinas

DTIC Science & Technology

1996-01-01

line. 51 U- U- )C nM-,L Cz2r r Zr’.r - -52 cz bi2 0z CPIu Inu leu bts 533 rMPF DWPF 39 36- 30------- - - - - - - - - - - - - PMiL 014- Gusr DARR 10- 6...14u cz lo0 Go0 Go a- Nr, lou 58 ,t, 7!Ch 59 Lr, CC 7 ~ cr cz 60 z u-, II Zn zc z 11 L1X - CL Aar- c- 61 100 CCu ac- Go 62 mm IflIN Z N _ m 63 TMPF DWPF

Survey of O-GlcNAc level variations in Xenopus laevis from oogenesis to early development.

PubMed

Dehennaut, Vanessa; Lefebvre, Tony; Leroy, Yves; Vilain, Jean-Pierre; Michalski, Jean-Claude; Bodart, Jean-François

2009-04-01

Little is known about the impact of O-linked-N-acetylglucosaminylation (O-GlcNAc) in gametes production and developmental processes. Here we investigated changes in O-GlcNAc, UDP-GlcNAc and O-GlcNAc transferase (OGT) levels in Xenopus laevis from oogenesis to embryo hatching. We showed that in comparison to stage VI, stages I-V oocytes expressed higher levels of O-GlcNAc correlating changes in OGT expression, but not in UDP-GlcNAc pools. Upon progesterone stimulation, an O-GlcNAc level burst occurred during meiotic resumption long before MPF and Mos-Erk2 pathways activations. Finally, we observed high levels of O-GlcNAc, UDP-GlcNAc and OGT during segmentation that decreased concomitantly at the onset of gastrulation. Nevertheless, no correlation between the glycosylation, the nucleotide-sugar and the glycosyltransferase was observed after neurulation. Our results show that O-GlcNAc is regulated throughout oogenesis and development within a complex pattern and suggest that dysfunctions in the dynamics of this glycosylation could lead to developmental abnormalities.

Characterization of Martian Rock Shape for MER Airbag Drop Tests

NASA Astrophysics Data System (ADS)

Dimaggio, E. N.; Schroeder, R.; Castle, N.; Golombek, M.

2002-12-01

Rock distributions for the final platforms used in airbag drop tests are currently being designed for the Mars Exploration Rovers (MER) scheduled to launch in 2003. Like Mars Pathfinder (MPF), launched in 1996, MER will use a series of airbags to cushion its landing on the surface of Mars. Previous MER airbag drop tests have shown that sharp, angular (triangular) rocks >20 cm high may be hazardous. To aid in defining the rock distributions for the final airbag tests, images from the Viking Landers 1 and 2 and MPF were used to identify rocks that are >20 cm high, and characterize them as triangular, square or round. Approximately 33% of all rocks analyzed are triangular. Of the rocks analyzed that are ~20-60 cm high, ~14% are triangular. Most of these triangular rocks are small, ~20-30 cm high. Rock distributions of previous airbag platforms were similarly classified and show a greater percentage of triangular and square rocks that are ~20-60 cm high than at the landing sites. The burial of a rock (perched, partially buried or buried) was also considered because perched rocks may pose less of a threat to the airbags than those buried because perched rocks can be dislodged and roll during impact. Approximately 19% of all rocks analyzed, and ~19% of rocks that are ~20-60 cm high, are triangular and partially buried or buried. These data suggest that the platform rock distributions appropriately represented the risks to the airbags associated with triangular rocks. A similar percentage of >20 cm high triangular rocks will be added to the drop test platforms to represent landing site rock distributions.

In vitro steroid-induced meiosis in Rhinella arenarum oocytes: role of pre-MPF activation.

PubMed

Arias Torres, Ana Josefina; Bühler, Marta Inés; Zelarayán, Liliana Isabel

2016-04-01

In this work we showed the relationship between seasonal periods and the response of R. arenarum follicles and oocytes to different steroids. Using in vitro germinal vesicle breakdown (GVBD) assays, we demonstrated that P4 is the main steroid capable of inducing maturation in R. arenarum oocytes and follicles. In the second part of this work we showed that androgens can activate pre-maturation promoting factors (pre-MPFs) such as P4, by cytoplasm microinjection experiments. The results indicated that the steroids assayed induced oocyte and follicle maturation in a dose- and time-dependent manner. In oocytes, P4 was the most efficient steroid as a maturation inducer (EC50 of the reproductive period, 6 nM, EC50 of the non-reproductive period ≅ 30 nM). Androgens (DHEA, dehydroepiandrosterone; T, testosterone; and AD, androstenedione) were less efficient maturation inducers than P4 (EC50 reproductive period ≅ 50, 120 and 600 nM respectively). Similar results were obtained with intact follicles in both seasonal periods. Although the response of follicles to the different androgens was variable, in no case was it above the above the response induced by P4. Independently of the season, oocytes and follicles incubated in P4, P5 and T underwent GVBD after 6-10 h while oocytes and follicles incubated in DHEA and AD matured more slowly. Furthermore, we demonstrated that microinjection of mature cytoplasm from androgen-treated oocytes is sufficient to promote GVBD in immature recipient oocytes (DHEA, 57 ± 12%; AD, 60 ± 8%; T, 56 ± 13%). Thus, androgens such as DHEA, T and AD are as competent as P4 to activate pre-MPF.

Role of arachidonic acid cascade in Rhinella arenarum oocyte maturation.

PubMed

Ortiz, Maria Eugenia; Arias-Torres, Ana Josefina; Zelarayán, Liliana Isabel

2015-08-01

There are no studies that document the production of prostaglandins (PGs) or their role in Rhinella arenarum oocyte maturation. In this study, we analysed the effect of arachidonic acid (AA) and prostaglandins (PGs) on maturation, activation and pronuclear formation in R. arenarum oocytes. Our results demonstrated that AA was capable of inducing maturation in time-dependent and dose-dependent manner. Arachidonic acid-induced maturation was inhibited by indomethacin. PGs from AA hydrolysis, such as prostaglandin F2α (PGF2α) and, to a lesser extent, PGE2, induced meiosis resumption. Oocyte maturation in response to PGF2α was similar to that produced by progesterone (P4). Oocyte response to PGE1 was scarce. Rhinella arenarum oocyte PGF2α-induced maturation showed seasonal variation. From February to June, oocytes presented low sensitivity to PGF2α. In following periods, this response increased until a maximum was reached during October to January, a close temporal correlation with oocyte response to P4 being observed. The effect of PGF2α on maturation was verified by analysing the capacity of oocytes to activate and form pronuclei after being injected with homologous sperm. The cytological analysis of activated oocytes demonstrated the absence of cortical granules in oocytes, suggesting that PGF2α induces germinal vesicle breakdown (GVBD) and meiosis resumption up to metaphase II. In turn, oocytes matured by the action of PGF2α were able to form pronuclei after fertilization in a similar way to oocyte maturated by P4. In microinjection of mature cytoplasm experiments, the transformation of pre-maturation promoting factor (pre-MPF) to MPF was observed when oocytes were treated with PGF2α. In summary, our results illustrated the participation of the AA cascade and its metabolites in maturation, activation and pronuclei formation in R. arenarum.

Rock Abrasion on Mars: Clues from the Pathfinder and Viking Landing Sites

NASA Technical Reports Server (NTRS)

Bridges, N. T.; Parker, T. J.; Kramer, G. M.

2000-01-01

A significant discovery of the Mars Pathfinder (MPF) mission was that many rocks exhibit characteristics of ventifacts, rocks that have been sculpted by saltating particles. Diagnostic features identifying the rocks as ventifacts am elongated pits, flutes, and grooves (collectively referred to as "flutes" unless noted otherwise). Faceted rocks or rock portions, circular pits, rills, and possibly polished rock surfaces are also seen and could be due, to aeolian abrasion. Many of these features were initially identified in rover images, where spatial resolution generally exceeded that of the IMP (Imager for Mars Pathfinder) camera. These images had two major limitations: 1) Only a limited number of rocks were viewed by the rover, biasing flute statistics; and 2) The higher resolution obtained by the rover images and the lack of such pictures at the Viking landing sites hampered comparisons of rock morphologies between the Pathfinder and Viking sites. To avoid this problem, rock morphology and ventifact statistics have been examined using new "super-resolution" IMP and Viking Lander images. Analyses of these images show that: 1) Flutes are seen on about 50% or more of the rocks in the near field at the MPF site; 2) The orientation of these flutes is similar to that for flutes identified in rover images; and 3) Ventifacts are significantly more abundant at the Pathfinder landing site than at the two Viking Landing sites, where rocks have undergone only a limited amount of aeolian abrasion. This is most likely due to the ruggedness of the Pathfinder site and a greater supply of abrading particles available shortly after the Arcs and Tiu Valles outflow channel floods.

The effect of exercise hypertrophy and disuse atrophy on muscle contractile properties: a mechanomyographic analysis.

PubMed

Than, Christian; Tosovic, Danijel; Seidl, Laura; Mark Brown, J

2016-12-01

To determine whether mechanomyographic (MMG) determined contractile properties of the biceps brachii change during exercise-induced hypertrophy and subsequent disuse atrophy. Healthy subjects (mean ± SD, 23.7 ± 2.6 years, BMI 21.8 ± 2.4, n = 19) performed unilateral biceps curls (9 sets × 12 repetitions, 5 sessions per week) for 8 weeks (hypertrophic phase) before ceasing exercise (atrophic phase) for the following 8 weeks (non-dominant limb; treatment, dominant limb; control). MMG measures of muscle contractile properties (contraction time; T c , maximum displacement; D max , contraction velocity; V c ), electromyographic (EMG) measures of muscle fatigue (median power frequency; MPF), strength measures (maximum voluntary contraction; MVC) and measures of muscle thickness (ultrasound) were obtained. Two-way repeated measures ANOVA showed significant differences (P < 0.05) between treatment and control limbs. During the hypertrophic phase treatment MVC initially declined (weeks 1-3), due to fatigue (decline in MPF), followed by improvement against control during weeks 6-8. Between weeks 5 and 8 treatment, muscle thickness was greater than control, reflecting gross hypertrophy. MMG variables Dmax (weeks 2, 7) and Vc (weeks 7, 8) declined. During the atrophic phase, MVC (weeks 9-12) and muscle thickness (weeks 9, 10) initially remained high before declining to control levels, reflecting gross atrophy. MMG variables D max (weeks 9, 14) and V c (weeks 9, 14, 15) also declined during the atrophic phase. No change in T c was found throughout the hypertrophic or atrophic phases. MMG detects changes in contractile properties during stages of exercise-induced hypertrophy and disuse atrophy suggesting its applicability as a clinical tool in musculoskeletal rehabilitation.

Herbal tea extract combined with light-induced significant in vitro cytotoxicity of human bladder cancer cells

NASA Astrophysics Data System (ADS)

Nseyo, Unyime; Kim, Albert; Stavropoulos, Nicholas E.; Skalkos, Dimitris; Nseyo, U. U.; Chung, Theodore D.

2005-04-01

The anti-inflammatory, anti-microbial, antiviral, and antidepressant activities of the Greek herb, Hypericum Perforatum L, HP L, have been attributed to the total extract or single constituents. We investigated the use of the extract,specifically of the polar methanolic fraction (PMF) of Epirus"HPL in photodynamic therapy (PDT) alone and in combination with recombinant Interferon-a2b (IFN) and gemcitabine (GCB) in the treatment of human bladder cancer cells. The PMF was extracted from the dry herb with methanol, followed by liquid-liquid extraction with petroleum ether. T-24 bladder cancer cells were plated (105 cells/well) and placed in the incubator (370 C, 5%CO) for 24 hours prior to addition of drugs. PMF 60ug/ml was added and incubation continued. After 24 hours, the cells were subjected to laser light (630nm) treatment with 0, 1, 4 and 8 Joules. After reincubation for 24 hours, IFN, (50,000 IU) or GCB, (2ug/ml) was added to the PDT-treated cells. After this incubation cell survival was assessed by the MTT assay. PMF-PDT alone-induced percent cell kill of 0%, 8%, 44% and 80% versus 31%, 64 and 86 % for PMF-PDT and IFN, versus 63%, 80% and 88% for MPF-PDT plus GCB at 1, 2, 4 and 8 Joules respectively. IFN and GCB induced 20% and 53% cell kill respectively. Our data suggest that MPF may be an effective agent for in vitro photodynamic therapy. PMF-PDT combined with Intron A, or gemcitabine achieved improved kill of cultured bladder cancer cells. Confirmation of these results in preclinical studies may lead to clinical trials.

Hypersonic and Supersonic Static Aerodynamics of Mars Science Laboratory Entry Vehicle

NASA Technical Reports Server (NTRS)

Dyakonov, Artem A.; Schoenenberger, Mark; Vannorman, John W.

2012-01-01

This paper describes the analysis of continuum static aerodynamics of Mars Science Laboratory (MSL) entry vehicle (EV). The method is derived from earlier work for Mars Exploration Rover (MER) and Mars Path Finder (MPF) and the appropriate additions are made in the areas where physics are different from what the prior entry systems would encounter. These additions include the considerations for the high angle of attack of MSL EV, ablation of the heatshield during entry, turbulent boundary layer, and other aspects relevant to the flight performance of MSL. Details of the work, the supporting data and conclusions of the investigation are presented.

Sojourner at "Mermaid Dune"

NASA Image and Video Library

1997-08-08

This is an image of the rover Sojourner at the feature called Mermaid Dune at the MPF landing site. Mermaid is thought to be a low, transverse dune ridge, with its long (approximately 2 meters) axis transverse to the wind, which is thought to come from the lower left of the image and blow toward the upper right. The rover is facing to the lower left, the "upwind" direction. The rover's middle wheels are at the crestline of the small dune, and the rear wheels are on the lee side of the feature. A soil mechanics experiment was performed to dig into the dune and examine the sediments exposed. http://photojournal.jpl.nasa.gov/catalog/PIA00794

MPF Lander Measured Surface Pressure

NASA Image and Video Library

1997-10-14

Here is a comparison of the most recent 24-hour met sessions. Note the general trend of increasing pressure with time into the mission. This indicates that the South polar cap is reducing, freeing CO2 into the atmosphere. Also note small pressure features around noon, which we think are "dust-devils." Sojourner spent 83 days of a planned seven-day mission exploring the Martian terrain, acquiring images, and taking chemical, atmospheric and other measurements. The final data transmission received from Pathfinder was at 10:23 UTC on September 27, 1997. Although mission managers tried to restore full communications during the following five months, the successful mission was terminated on March 10, 1998. http://photojournal.jpl.nasa.gov/catalog/PIA00976

Studies of MGS TES and MPF MET Data

NASA Technical Reports Server (NTRS)

Barnes, Jeff R.

2003-01-01

The work supported by this grant was divided into two broad areas: (1) mesoscale modeling of atmospheric circulations and analyses of Pathfinder, Viking, and other Mars data, and (2) analyses of MGS TES temperature data. The mesoscale modeling began with the development of a suitable Mars mesoscale model based upon the terrestrial MM5 model, which was then applied to the simulation of the meteorological observations at the Pathfinder and Viking Lander 1 sites during northern summer. This extended study served a dual purpose: to validate the new mesoscale model with the best of the available in-situ data, and to use the model to aid in the interpretation of the surface meteorological data.

Crystal structure of Ca{sub 12}Al{sub 14}O{sub 32}Cl{sub 2} and luminescence properties of Ca{sub 12}Al{sub 14}O{sub 32}Cl{sub 2}:Eu{sup 2+}

DOE Office of Scientific and Technical Information (OSTI.GOV)

Iwata, Tomoyuki; Haniuda, Masahide; Fukuda, Koichiro

2008-01-15

The crystal structure of Ca{sub 12}Al{sub 14}O{sub 32}Cl{sub 2} was determined from laboratory X-ray powder diffraction data (CuK{alpha}{sub 1}) using the Rietveld method, with the anisotropic displacement parameters being assigned for all atoms. The crystal structure is cubic (space group I4-bar 3d, Z=2) with lattice dimensions a=1.200950(5) nm and V=1.73211(1) nm{sup 3}. The reliability indices calculated from the Rietveld method were R{sub wp}=8.48% (S=1.21), R{sub p}=6.05%, R{sub B}=1.27% and R{sub F}=1.01%. The validity of the structural model was verified by the three-dimensional electron density distribution, the structural bias of which was reduced as much as possible using the maximum-entropy methods-basedmore » pattern fitting (MPF). The reliability indices calculated from the MPF were R{sub B}=0.75% and R{sub F}=0.56%. In the structural model there are one Ca site, two Al sites, two O sites and one Cl site. This compound is isomorphous with Ca{sub 12}Al{sub 10.6}Si{sub 3.4}O{sub 32}Cl{sub 5.4}. Europium-doped sample Ca{sub 12}Al{sub 14}O{sub 32}Cl{sub 2}:Eu{sup 2+} was prepared and the photoluminescence properties were presented. The excitation spectrum consisted of two wide bands, which were located at about 268 and 324 nm. The emission spectrum, when excited at 324 nm, resulted in indigo light with a peak at about 442 nm. - Graphical abstract: A portion of the crystal structure of Ca{sub 12}Al{sub 14}O{sub 32}Cl{sub 2} showing eight-membered AlO{sub 4} rings and Ca-Cl-Ca unit.« less

Bovine oocyte meiotic inhibition before in vitro maturation and its value to in vitro embryo production: does it improve developmental competence?

PubMed

Bilodeau-Goeseels, S

2012-08-01

The efficiency of bovine in vitro embryo production has remained low despite extensive effort to understand the effects of culture conditions, media composition and supplementation. As bovine oocytes resume meiosis spontaneously when cultured, it was hypothesized that preventing meiosis in vitro before in vitro maturation (IVM) and in vitro fertilization (IVF) would allow more oocytes to acquire developmental competence. This article reviews some of the factors involved in meiotic arrest as well as the effects of meiotic inhibition before IVM on bovine oocytes developmental competence following IVF. Follicular components and cAMP-elevating agents can delay or inhibit meiosis in various proportions of oocytes; however, few studies have examined their effects on development following IVM and IVF because they are not practical (follicular components) or have a transient effect on meiosis (cAMP-elevating agents). Protein synthesis or phosphorylation inhibition prevented meiosis in high percentages of oocytes; however, these non-specific inhibitions led to lower developmental competence compared with non-arrested oocytes. Maturation promoting factor (MPF) inhibition with specific inhibitors has been examined in several studies. Despite faster maturation following removal from inhibition and some structural damage to the oocytes, MPF inhibition generally led to blastocyst rates similar to control, non-arrested oocytes. Future work will involve evaluating the effects on arrested oocytes of molecules that can improve developmental competence in non-arrested oocytes. It is also anticipated that new IVM systems that take into consideration new knowledge of the mechanisms involved in the control of meiosis will be developed. Moreover, global gene expression analysis studies will also provide clues to the culture conditions required for optimal expression of developmental competence. © Her Majesty the Queen in Right of Canada 2011. Reproduced with the permission of the Minister of Agriculture and Agri-Food Canada.

A multi-parametric particle-pairing algorithm for particle tracking in single and multiphase flows

NASA Astrophysics Data System (ADS)

Cardwell, Nicholas D.; Vlachos, Pavlos P.; Thole, Karen A.

2011-10-01

Multiphase flows (MPFs) offer a rich area of fundamental study with many practical applications. Examples of such flows range from the ingestion of foreign particulates in gas turbines to transport of particles within the human body. Experimental investigation of MPFs, however, is challenging, and requires techniques that simultaneously resolve both the carrier and discrete phases present in the flowfield. This paper presents a new multi-parametric particle-pairing algorithm for particle tracking velocimetry (MP3-PTV) in MPFs. MP3-PTV improves upon previous particle tracking algorithms by employing a novel variable pair-matching algorithm which utilizes displacement preconditioning in combination with estimated particle size and intensity to more effectively and accurately match particle pairs between successive images. To improve the method's efficiency, a new particle identification and segmentation routine was also developed. Validation of the new method was initially performed on two artificial data sets: a traditional single-phase flow published by the Visualization Society of Japan (VSJ) and an in-house generated MPF data set having a bi-modal distribution of particles diameters. Metrics of the measurement yield, reliability and overall tracking efficiency were used for method comparison. On the VSJ data set, the newly presented segmentation routine delivered a twofold improvement in identifying particles when compared to other published methods. For the simulated MPF data set, measurement efficiency of the carrier phases improved from 9% to 41% for MP3-PTV as compared to a traditional hybrid PTV. When employed on experimental data of a gas-solid flow, the MP3-PTV effectively identified the two particle populations and reported a vector efficiency and velocity measurement error comparable to measurements for the single-phase flow images. Simultaneous measurement of the dispersed particle and the carrier flowfield velocities allowed for the calculation of instantaneous particle slip velocities, illustrating the algorithm's strength to robustly and accurately resolve polydispersed MPFs.

Energy cost and lower leg muscle activities during erect bipedal locomotion under hyperoxia.

PubMed

Abe, Daijiro; Fukuoka, Yoshiyuki; Maeda, Takafumi; Horiuchi, Masahiro

2018-06-19

Energy cost of transport per unit distance (CoT) against speed shows U-shaped fashion in walking and linear fashion in running, indicating that there exists a specific walking speed minimizing the CoT, being defined as economical speed (ES). Another specific gait speed is the intersection speed between both fashions, being called energetically optimal transition speed (EOTS). We measured the ES, EOTS, and muscle activities during walking and running at the EOTS under hyperoxia (40% fraction of inspired oxygen) on the level and uphill gradients (+ 5%). Oxygen consumption [Formula: see text] and carbon dioxide output [Formula: see text] were measured to calculate the CoT values at eight walking speeds (2.4-7.3 km h -1 ) and four running speeds (7.3-9.4 km h - 1 ) in 17 young males. Electromyography was recorded from gastrocnemius medialis, gastrocnemius lateralis (GL), and tibialis anterior (TA) to evaluate muscle activities. Mean power frequency (MPF) was obtained to compare motor unit recruitment patterns between walking and running. [Formula: see text], [Formula: see text], and CoT values were lower under hyperoxia than normoxia at faster walking speeds and any running speeds. A faster ES on the uphill gradient and slower EOTS on both gradients were observed under hyperoxia than normoxia. GL and TA activities became lower when switching from walking to running at the EOTS under both FiO 2 conditions on both gradients, so did the MPF in the TA. ES and EOTS were influenced by reduced metabolic demands induced by hyperoxia. GL and TA activities in association with a lower shift of motor unit recruitment patterns in the TA would be related to the gait selection when walking or running at the EOTS. UMIN000017690 ( R000020501 ). Registered May 26, 2015, before the first trial.

Experimental research and numerical optimisation of multi-point sheet metal forming implementation using a solid elastic cushion system

NASA Astrophysics Data System (ADS)

Tolipov, A. A.; Elghawail, A.; Shushing, S.; Pham, D.; Essa, K.

2017-09-01

There is a growing demand for flexible manufacturing techniques that meet the rapid changes in customer needs. A finite element analysis numerical optimisation technique was used to optimise the multi-point sheet forming process. Multi-point forming (MPF) is a flexible sheet metal forming technique where the same tool can be readily changed to produce different parts. The process suffers from some geometrical defects such as wrinkling and dimpling, which have been found to be the cause of the major surface quality problems. This study investigated the influence of parameters such as the elastic cushion hardness, blank holder force, coefficient of friction, cushion thickness and radius of curvature, on the quality of parts formed in a flexible multi-point stamping die. For those reasons, in this investigation, a multipoint forming stamping process using a blank holder was carried out in order to study the effects of the wrinkling, dimpling, thickness variation and forming force. The aim was to determine the optimum values of these parameters. Finite element modelling (FEM) was employed to simulate the multi-point forming of hemispherical shapes. Using the response surface method, the effects of process parameters on wrinkling, maximum deviation from the target shape and thickness variation were investigated. The results show that elastic cushion with proper thickness and polyurethane with the hardness of Shore A90. It has also been found that the application of lubrication cans improve the shape accuracy of the formed workpiece. These final results were compared with the numerical simulation results of the multi-point forming for hemispherical shapes using a blank-holder and it was found that using cushion hardness realistic to reduce wrinkling and maximum deviation.

Investigating the two-moment characterisation of subcellular biochemical networks.

PubMed

Ullah, Mukhtar; Wolkenhauer, Olaf

2009-10-07

While ordinary differential equations (ODEs) form the conceptual framework for modelling many cellular processes, specific situations demand stochastic models to capture the influence of noise. The most common formulation of stochastic models for biochemical networks is the chemical master equation (CME). While stochastic simulations are a practical way to realise the CME, analytical approximations offer more insight into the influence of noise. Towards that end, the two-moment approximation (2MA) is a promising addition to the established analytical approaches including the chemical Langevin equation (CLE) and the related linear noise approximation (LNA). The 2MA approach directly tracks the mean and (co)variance which are coupled in general. This coupling is not obvious in CME and CLE and ignored by LNA and conventional ODE models. We extend previous derivations of 2MA by allowing (a) non-elementary reactions and (b) relative concentrations. Often, several elementary reactions are approximated by a single step. Furthermore, practical situations often require the use of relative concentrations. We investigate the applicability of the 2MA approach to the well-established fission yeast cell cycle model. Our analytical model reproduces the clustering of cycle times observed in experiments. This is explained through multiple resettings of M-phase promoting factor (MPF), caused by the coupling between mean and (co)variance, near the G2/M transition.

Mars Pathfinder Landing Site: Evidence for a Change in Wind Regime from Lander and Orbiter Data

NASA Technical Reports Server (NTRS)

Greeley, Ronald; Kraft, Michael D.; Kuzmin, Ruslan O.; Bridges, Nathan T.

2000-01-01

Surface features related to the wind are observed in the vicinity of the Mars Pathfinder (MPR landing site data from the lander and in data from orbit by the Viking Orbiter and Mars Global Surveyor missions. Features seen from the surface include wind tails associated with small rocks, barchanoid duneforms, ripplelike patterns, and ventifact flutes cut into some rocks. Features seen from orbit include wind tails associated with impact craters, ridges inferred to be duneforms, and modified crater rims interpreted to have been eroded and mantled by windblown material. The orientations of these features show two prevailing directions. One is inferred to represent winds from the northeast, which is consistent with strongest winds predicted by a general circulation model to occur during the Martian northern winter under current conditions. A second wind blowing from the ESE was responsible for modifying the crater rims and cutting some of the ventifacts. The two wind regimes could reflect a change in climate related to Mars' obliquity or some other, unknown factor. Regardless of the cause, the MPF area has been subjected to a complex pattern of winds and supply of small particles, and the original surface formed by sedimentary processes from Tiu and Ares Vallis flooding events has been modified by repeated burial and exhumation.

Muscle activities during walking and running at energetically optimal transition speed under normobaric hypoxia on gradient slopes

PubMed Central

Fukuoka, Yoshiyuki; Horiuchi, Masahiro

2017-01-01

Energy cost of transport per unit distance (CoT; J·kg-1·km-1) displays a U-shaped fashion in walking and a linear fashion in running as a function of gait speed (v; km·h-1). There exists an intersection between U-shaped and linear CoT-v relationships, being termed energetically optimal transition speed (EOTS; km·h-1). Combined effects of gradient and moderate normobaric hypoxia (15.0% O2) were investigated when walking and running at the EOTS in fifteen young males. The CoT values were determined at eight walking speeds (2.4–7.3 km·h-1) and four running speeds (7.3–9.4 km·h-1) on level and gradient slopes (±5%) at normoxia and hypoxia. Since an alteration of tibialis anterior (TA) activity has been known as a trigger for gait transition, electromyogram was recorded from TA and its antagonists (gastrocnemius medialis (GM) and gastrocnemius lateralis (GL)) for about 30 steps during walking and running corresponding to the individual EOTS in each experimental condition. Mean power frequency (MPF; Hz) of each muscle was quantified to evaluate alterations of muscle fiber recruitment pattern. The EOTS was not significantly different between normoxia and hypoxia on any slopes (ranging from 7.412 to 7.679 km·h-1 at normoxia and 7.516 to 7.678 km·h-1 at hypoxia) due to upward shifts (enhanced metabolic rate) of both U-shaped and linear CoT-v relationships at hypoxia. GM, but not GL, activated more when switching from walking to running on level and gentle downhill slopes. Significant decreases in the muscular activity and/or MPF were observed only in the TA when switching the gait pattern. Taken together, the EOTS was not slowed by moderate hypoxia in the population of this study. Muscular activities of lower leg extremities and those muscle fiber recruitment patterns are dependent on the gradient when walking and running at the EOTS. PMID:28301525

The slow component of O(2) uptake is not accompanied by changes in muscle EMG during repeated bouts of heavy exercise in humans.

PubMed

Scheuermann, B W; Hoelting, B D; Noble, M L; Barstow, T J

2001-02-15

1. We hypothesized that either the recruitment of additional muscle motor units and/or the progressive recruitment of less efficient fast-twitch muscle fibres was the predominant contributor to the additional oxygen uptake (VO2) observed during heavy exercise. Using surface electromyographic (EMG) techniques, we compared the VO2 response with the integrated EMG (iEMG) and mean power frequency (MPF) response of the vastus lateralis with the VO2 response during repeated bouts of moderate (below the lactate threshold, < LT) and heavy (above the lactate threshold, > LT) intensity cycle ergometer exercise. 2. Seven male subjects (age 29 +/- 7 years, mean +/- S.D.) performed three transitions to a work rate (WR) corresponding to 90 % LT and two transitions to a work rate that would elicit a VO2 corresponding to 50 % of the difference between peak VO2 and the LT (i.e. Delta50 %, > LT1 and > LT2). 3. The VO2 slow component was significantly reduced by prior heavy intensity exercise (> LT1, 410 +/- 196 ml min(-1); > LT2, 230 +/- 191 ml min-1). The time constant (tau), amplitude (A) and gain (DeltaVO2/DeltaWR) of the primary VO2 response (phase II) were not affected by prior heavy exercise when a three-component, exponential model was used to describe the V2 response. 4. Integrated EMG and MPF remained relatively constant and at the same level throughout both > LT1 and > LT2 exercise and therefore were not associated with the VO2 slow component. 5. These data are consistent with the view that the increased O2 cost (i.e. VO2 slow component) associated with performing heavy exercise is coupled with a progressive increase in ATP requirements of the already recruited motor units rather than to changes in the recruitment pattern of slow versus fast-twitch motor units. Further, the lack of speeding of the kinetics of the primary VO2 component with prior heavy exercise, thought to represent the initial muscle VO2 response, are inconsistent with O2 delivery being the limiting factor in V > O2 kinetics during heavy exercise.

Determining Changes in Electromyography Indices when Measuring Maximum Acceptable Weight of Lift in Iranian Male Students.

PubMed

Salehi Sahl Abadi, A; Mazloumi, A; Nasl Saraji, G; Zeraati, H; Hadian, M R; Jafari, A H

2018-03-01

In spite of the increasing degree of automation in industry, manual material handling (MMH) is still performed in many occupational settings. The aim of the current study was to determine the maximum acceptable weight of lift using psychophysical and electromyography indices. This experimental study was conducted among 15 male students recruited from Tehran University of Medical Sciences. Each participant performed 18 different lifting tasks which involved three lifting frequencies, three lifting heights and two box sizes. Each set of experiments was conducted during the 20 min work period using free-style lifting technique and subjective as well as objective assessment methodologies. SPSS version 18 software was used for descriptive and analytical analyses by Friedman, Wilcoxon and Spearman correlation techniques. The results demonstrated that muscle activity increased with increasing frequency, height of lift and box size (P<0.05). Meanwhile, MAWLs obtained in this study are lower than those in Snook table (P<0.05). In this study, the level of muscle activity in percent MVC in relation to the erector spine muscles in L3 and T9 regions as well as left and right abdominal external oblique muscles were at 38.89%, 27.78%, 11.11% and 5.55% in terms of muscle activity is more than 70% MVC, respectively. The results of Wilcoxon test revealed that for both small and large boxes under all conditions, significant differences were detected between the beginning and end of the test values for MPF of erector spine in L3 and T9 regions, and left and right abdominal external oblique muscles (P<0.05). The results of Spearman correlation test showed that there was a significant relation between the MAWL, RMS and MPF of the muscles in all test conditions (P<0.05). Based on the results of this study, it was concluded if muscle activity is more than 70% of MVC, the values of Snook tables should be revisited. Furthermore, the biomechanical perspective should receive special attention in determining the standards for MMH.

Theoretical Study of the Endogenous Production of N-13 in 115 kJ Plasma Focus Device Using Methane Gas

NASA Astrophysics Data System (ADS)

Faghih Haghani, Saeedeh; Sadighzadeh, A.; Talaei, A.; Zaeem, A. A.; Sadat Kiai, S. M.; Heydarnia, A.; Damideh, V.

2013-08-01

Mather type plasma focus device with the bank energy of 115 kJ (40 kV, 144μF) was studied for induced activity of N-13; a short-lived radioisotope β+ emitter with 511 keV of gamma rays and has a half-life of t1/2 = 9.93 min through 12C (d, n)13N nuclear reaction. N-13 radioisotope is used in Positron Emission Tomography (PET) for imaging and treatment. In this paper endogenous production of 13N is considered. It is shown by adding 3-4 % CH4 to the chamber, the induced activity of N-13 has increased about 4 %. Our study is representative of producing 106 - 109 Bq induced activity of this SLR in IR-MPF-100 device.

Mars Pathfinder Landing Site: Evidence for a Change in Wind Regime and Climate from Lander and Orbiter Data

NASA Technical Reports Server (NTRS)

Greeley, R.; Kraft, M. D.; Kuzmin, R. O.; Bridges, N. T.

1999-01-01

Surface features related to the wind are observed in data from the Mars Pathfinder lander and from orbit by the Viking Orbiter and Mars Global Surveyor missions. Features seen from the surface include wind tails associated with small rocks, barchanoid duneforms, ripplelike patterns, and ventifact flutes cut into some rocks. Features seen from orbit include wind tails associated with impact craters, ridges inferred to be duneforms, and modified crater rims interpreted to have been eroded and mantled by windblown material. The orientations of these features show two prevailing directions, one inferred to represent winds from the northeast which is consistent with strongest winds predicted by a general circulation model to occur during the Martian northern winter under current conditions, and a second wind pattern oriented approx. 90 degrees to the first. This latter wind could be from the W-NW or from the E-SE and was responsible for cutting the ventifacts and modifying the crater rims. The two wind regimes could reflect a change in climate related to Mars' obliquity or some other, unknown factor. Regardless of the cause, the MPF area has been subjected to a complex pattern of winds and supply of small particles, in which the original surface formed by sedimentary processes from Tiu and Ares Vallis events has been modified by repeated burial and exhumation.

Safeguards Approaches for Black Box Processes or Facilities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Diaz-Marcano, Helly; Gitau, Ernest TN; Hockert, John

2013-09-25

The objective of this study is to determine whether a safeguards approach can be developed for “black box” processes or facilities. These are facilities where a State or operator may limit IAEA access to specific processes or portions of a facility; in other cases, the IAEA may be prohibited access to the entire facility. The determination of whether a black box process or facility is safeguardable is dependent upon the details of the process type, design, and layout; the specific limitations on inspector access; and the restrictions placed upon the design information that can be provided to the IAEA. Thismore » analysis identified the necessary conditions for safeguardability of black box processes and facilities.« less

40 CFR 52.279 - Food processing facilities.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 3 2012-07-01 2012-07-01 false Food processing facilities. 52.279... (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS California § 52.279 Food processing facilities... emissions from food processing facilities without any accompanying analyses demonstrating that these...

40 CFR 52.279 - Food processing facilities.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 3 2014-07-01 2014-07-01 false Food processing facilities. 52.279... (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS California § 52.279 Food processing facilities... emissions from food processing facilities without any accompanying analyses demonstrating that these...

40 CFR 52.279 - Food processing facilities.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 3 2011-07-01 2011-07-01 false Food processing facilities. 52.279... (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS California § 52.279 Food processing facilities... emissions from food processing facilities without any accompanying analyses demonstrating that these...

40 CFR 52.279 - Food processing facilities.

Code of Federal Regulations, 2013 CFR

2013-07-01

... emissions from food processing facilities without any accompanying analyses demonstrating that these... 40 Protection of Environment 3 2013-07-01 2013-07-01 false Food processing facilities. 52.279... (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS California § 52.279 Food processing facilities...

15 CFR 923.13 - Energy facility planning process.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Energy facility planning process. 923... RESOURCE MANAGEMENT COASTAL ZONE MANAGEMENT PROGRAM REGULATIONS Uses Subject to Management § 923.13 Energy facility planning process. The management program must contain a planning process for energy facilities...

15 CFR 923.13 - Energy facility planning process.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 15 Commerce and Foreign Trade 3 2012-01-01 2012-01-01 false Energy facility planning process. 923... RESOURCE MANAGEMENT COASTAL ZONE MANAGEMENT PROGRAM REGULATIONS Uses Subject to Management § 923.13 Energy facility planning process. The management program must contain a planning process for energy facilities...

15 CFR 923.13 - Energy facility planning process.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 3 2013-01-01 2013-01-01 false Energy facility planning process. 923... RESOURCE MANAGEMENT COASTAL ZONE MANAGEMENT PROGRAM REGULATIONS Uses Subject to Management § 923.13 Energy facility planning process. The management program must contain a planning process for energy facilities...

15 CFR 923.13 - Energy facility planning process.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 15 Commerce and Foreign Trade 3 2011-01-01 2011-01-01 false Energy facility planning process. 923... RESOURCE MANAGEMENT COASTAL ZONE MANAGEMENT PROGRAM REGULATIONS Uses Subject to Management § 923.13 Energy facility planning process. The management program must contain a planning process for energy facilities...

15 CFR 923.13 - Energy facility planning process.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 15 Commerce and Foreign Trade 3 2014-01-01 2014-01-01 false Energy facility planning process. 923... RESOURCE MANAGEMENT COASTAL ZONE MANAGEMENT PROGRAM REGULATIONS Uses Subject to Management § 923.13 Energy facility planning process. The management program must contain a planning process for energy facilities...

A Presumptive Developmental Role for a Sea Urchin Cyclin B Splice Variant

PubMed Central

Lozano, Jean-Claude; Schatt, Philippe; Marquès, François; Peaucellier, Gérard; Fort, Philippe; Féral, Jean-Pierre; Genevière, Anne-Marie; Picard, André

1998-01-01

We show that a splice variant–derived cyclin B is produced in sea urchin oocytes and embryos. This splice variant protein lacks highly conserved sequences in the COOH terminus of the protein. It is found strikingly abundant in growing oocytes and cells committed to differentiation during embryogenesis. Cyclin B splice variant (CBsv) protein associates weakly in the cell with Xenopus cdc2 and with budding yeast CDC28p. In contrast to classical cyclin B, CBsv very poorly complements a triple CLN deletion in budding yeast, and its microinjection prevents an initial step in MPF activation, leading to an important delay in oocyte meiosis reinitiation. CBsv microinjection in fertilized eggs induces cell cycle delay and abnormal development. We assume that CBsv is produced in growing oocytes to keep them in prophase, and during embryogenesis to slow down cell cycle in cells that will be committed to differentiation. PMID:9442104

Segmentation of ECG from Surface EMG Using DWT and EMD: A Comparison Study

NASA Astrophysics Data System (ADS)

Shahbakhti, Mohammad; Heydari, Elnaz; Luu, Gia Thien

2014-10-01

The electrocardiographic (ECG) signal is a major artifact during recording the surface electromyography (SEMG). Removal of this artifact is one of the important tasks before SEMG analysis for biomedical goals. In this paper, the application of discrete wavelet transform (DWT) and empirical mode decomposition (EMD) for elimination of ECG artifact from SEMG is investigated. The focus of this research is to reach the optimized number of decomposed levels using mean power frequency (MPF) by both techniques. In order to implement the proposed methods, ten simulated and three real ECG contaminated SEMG signals have been tested. Signal-to-noise ratio (SNR) and mean square error (MSE) between the filtered and the pure signals are applied as the performance indexes of this research. The obtained results suggest both techniques could remove ECG artifact from SEMG signals fair enough, however, DWT performs much better and faster in real data.

A review of MRI evaluation of demyelination in cuprizone murine model

NASA Astrophysics Data System (ADS)

Krutenkova, E.; Pan, E.; Khodanovich, M.

2015-11-01

The cuprizone mouse model of non-autoimmune demyelination reproduces some phenomena of multiple sclerosis and is appropriate for validation and specification of a new method of non-invasive diagnostics. In the review new data which are collected using the new MRI method are compared with one or more conventional MRI tools. Also the paper reviewed the validation of MRI approaches using histological or immunohistochemical methods. Luxol fast blue histological staining and myelin basic protein immunostaining is widespread. To improve the accuracy of non-invasive conventional MRI, multimodal scanning could be applied. The new quantitative MRI method of fast mapping of the macromolecular proton fraction is a reliable biomarker of myelin in the brain and can be used for research of demyelination in animals. To date, a validation of MPF method on the CPZ mouse model of demyelination is not performed, although this method is probably the best way to evaluate demyelination using MRI.

Anticandidal activity and interleukin-1 beta and interleukin-6 production by polymorphonuclear leukocytes are preserved in subjects with AIDS.

PubMed Central

Cassone, A; Palma, C; Djeu, J Y; Aiuti, F; Quinti, I

1993-01-01

Polymorphonuclear granulocytes (PMN; or neutrophils) from uninfected or human immunodeficiency virus-infected subjects were tested for their ability to inhibit growth of Candida albicans and produce interleukin-1 beta (IL-1 beta) and IL-6 in vitro. It was seen that PMN from AIDS (Centers for Disease Control stage IV) patients expressed equal if not greater anticandidal activity compared with the activity expressed by neutrophils from all other subjects examined. On exposure to granulocyte macrophage-colony-stimulating factor or to a mannoprotein constituent (MP-F2) from C. albicans itself, PMN from AIDS patients showed enhanced antifungal activity and production of remarkable quantities of IL-1 beta and IL-6. These findings suggest that the functional abilities of PMN to inhibit Candida growth and secrete relevant proinflammatory and immunomodulatory cytokines are intrinsically preserved in AIDS patients. PMID:8501241

40 CFR 122.3 - Exclusions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... an energy or mining facility, a storage facility or a seafood processing facility, or when secured to a storage facility or a seafood processing facility, or when secured to the bed of the ocean...

40 CFR 122.3 - Exclusions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... an energy or mining facility, a storage facility or a seafood processing facility, or when secured to a storage facility or a seafood processing facility, or when secured to the bed of the ocean...

40 CFR 122.3 - Exclusions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... an energy or mining facility, a storage facility or a seafood processing facility, or when secured to a storage facility or a seafood processing facility, or when secured to the bed of the ocean...

40 CFR 122.3 - Exclusions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... an energy or mining facility, a storage facility or a seafood processing facility, or when secured to a storage facility or a seafood processing facility, or when secured to the bed of the ocean...

40 CFR 122.3 - Exclusions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... an energy or mining facility, a storage facility or a seafood processing facility, or when secured to a storage facility or a seafood processing facility, or when secured to the bed of the ocean...

State machine analysis of sensor data from dynamic processes

DOEpatents

Cook, William R.; Brabson, John M.; Deland, Sharon M.

2003-12-23

A state machine model analyzes sensor data from dynamic processes at a facility to identify the actual processes that were performed at the facility during a period of interest for the purpose of remote facility inspection. An inspector can further input the expected operations into the state machine model and compare the expected, or declared, processes to the actual processes to identify undeclared processes at the facility. The state machine analysis enables the generation of knowledge about the state of the facility at all levels, from location of physical objects to complex operational concepts. Therefore, the state machine method and apparatus may benefit any agency or business with sensored facilities that stores or manipulates expensive, dangerous, or controlled materials or information.

Shape-persistent nanosize organometallic complexes: synthesis and application in a nanofiltration membrane reactor.

PubMed

Dijkstra, Harm P; Kruithof, Cornelis A; Ronde, Niek; Van De Coevering, Rob; Ramón, Diego J; Vogt, Dieter; Van Klink, Gerard P M; Van Koten, Gerard

2003-02-07

Shape-persistent multi(NCN-palladium and/or -platinum) complexes having one- (5 and 6), two- (1 and 2), and three-dimensional (3 and 4) geometries were prepared in moderate to good yields. Two different approaches were used to construct the multimetallic materials: (i) the construction of the multisite ligands followed by the permetalation step and (ii) selective and mild one-pot coupling of monometallic buiding blocks to a multifunctional shape-persistent organic core molecule. The first approach was used to prepare the palladated and/or platinated tris- (2) and bis(NCN-pincer) (5) complexes, while the second approach afforded the palladated and platinated octakis- (3) and dodecakis(NCN-pincer) (4) complexes. Complexes 1-6 were subjected to nanofiltration (NF) experiments in order to investigate the influence of rigidity and geometry on the retention of these molecules by NF membranes. For this purpose, the corresponding (NCN-Pt-X)(n)() complexes (1c-4c, 5, and 6) were used since exposing these complexes to sulfur dioxide in solution resulted in the formation of bright orange complexes, allowing the use of UV/vis spectroscopy to accurately determine the concentrations of 1-6 in both retentate and permeate. Using the MPF-60 (MWCO = 400) NF-membrane, retention rates of 82.4 (6), 93.9 (1c), 98.7 (2c), 99.5 (3c), 99.6 (5), and >99.9% (4c) were found, while 2c and 4c in combination with the MPF-50 (MWCO = 700) NF-membrane were retained in 97.6 and 99.9%, respectively. A clear relationship is observed between the dimensions calculated by molecular modeling and the retention rates of 1-6. The one-dimensional bis(pincer-platinum) complex 5, however, shows an unexpectedly high retention rate (99.6%) that can be due to precipitation of the complex in the membrane (clogging of the membrane) and/or to the formation of larger aggregates near the membrane. In addition, comparison of 2 and 4 with flexible nickelated G0- and G1-dendrimers with similar dimensions proved that a high degree of rigidity in the backbone of macromolecular complexes indeed leads to more efficient retentions of these multimetallic materials by NF-membranes.

Electron density distribution and disordered crystal structure of 15R-SiAlON, SiAl{sub 4}O{sub 2}N{sub 4}

DOE Office of Scientific and Technical Information (OSTI.GOV)

Banno, Hiroki; Hanai, Takaaki; Asaka, Toru

2014-03-15

The crystal structure of SiAl{sub 4}O{sub 2}N{sub 4} was characterized by laboratory X-ray powder diffraction (CuKα{sub 1}). The title compound is trigonal with space group R3-bar m. The hexagonal unit-cell dimensions (Z=3) are a=0.301332(3) nm, c=4.18616(4) nm and V=0.3291825(5) nm{sup 3}. The initial structural model was successfully derived by the charge-flipping method and further refined by the Rietveld method. The final structural model showed the positional disordering of one of the three (Si,Al) sites. The maximum-entropy method-based pattern fitting (MPF) method was used to confirm the validity of the split-atom model, in which conventional structure bias caused by assuming intensitymore » partitioning was minimized. The reliability indices calculated from the MPF were R{sub wp}=5.05%, S (=R{sub wp}/R{sub e})=1.21, R{sub p}=3.77%, R{sub B}=1.29% and R{sub F}=1.01%. The disordered crystal structure was successfully described by overlapping three types of domains with ordered atom arrangements. The distribution of atomic positions in one of the three types of domains can be achieved in the space group R3-bar m. The atom arrangements in the other two types of domains are noncentrosymmetrical with the space group R3m. These two structural configurations are related by the pseudo-symmetry inversion. -- Graphical abstract: A bird's eye view of electron densities up to 75.3% (0.133 nm{sup −3}) of the maximum on the plane parallel to (110) with the corresponding atomic arrangements of SiAl{sub 4}O{sub 2}N{sub 4}. Highlights: • Crystal structure of SiAl{sub 4}O{sub 2}N{sub 4} is determined by laboratory X-ray powder diffraction. • The atom arrangements are represented by the split-atom model. • The maximum-entropy method-based pattern fitting method is used to confirm the validity of the model. • The disordered structure is described by overlapping three types of domains with ordered atom arrangements.« less

Proposal for a new categorization of aseptic processing facilities based on risk assessment scores.

PubMed

Katayama, Hirohito; Toda, Atsushi; Tokunaga, Yuji; Katoh, Shigeo

2008-01-01

Risk assessment of aseptic processing facilities was performed using two published risk assessment tools. Calculated risk scores were compared with experimental test results, including environmental monitoring and media fill run results, in three different types of facilities. The two risk assessment tools used gave a generally similar outcome. However, depending on the tool used, variations were observed in the relative scores between the facilities. For the facility yielding the lowest risk scores, the corresponding experimental test results showed no contamination, indicating that these ordinal testing methods are insufficient to evaluate this kind of facility. A conventional facility having acceptable aseptic processing lines gave relatively high risk scores. The facility showing a rather high risk score demonstrated the usefulness of conventional microbiological test methods. Considering the significant gaps observed in calculated risk scores and in the ordinal microbiological test results between advanced and conventional facilities, we propose a facility categorization based on risk assessment. The most important risk factor in aseptic processing is human intervention. When human intervention is eliminated from the process by advanced hardware design, the aseptic processing facility can be classified into a new risk category that is better suited for assuring sterility based on a new set of criteria rather than on currently used microbiological analysis. To fully benefit from advanced technologies, we propose three risk categories for these aseptic facilities.

77 FR 823 - Guidance for Fuel Cycle Facility Change Processes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-06

... NUCLEAR REGULATORY COMMISSION [NRC-2009-0262] Guidance for Fuel Cycle Facility Change Processes... Fuel Cycle Facility Change Processes.'' This regulatory guide describes the types of changes for which fuel cycle facility licensees should seek prior approval from the NRC and discusses how licensees can...

Spacelab Data Processing Facility

NASA Technical Reports Server (NTRS)

1983-01-01

The capabilities of the Spacelab Data Processing Facility (SPDPF) are highlighted. The capturing, quality monitoring, processing, accounting, and forwarding of vital Spacelab data to various user facilities around the world are described.

18 CFR 157.21 - Pre-filing procedures and review process for LNG terminal facilities and other natural gas...

Code of Federal Regulations, 2010 CFR

2010-04-01

... the pre-filing review of any pipeline or other natural gas facilities, including facilities not... from the subject LNG terminal facilities to the existing natural gas pipeline infrastructure. (b) Other... and review process for LNG terminal facilities and other natural gas facilities prior to filing of...

78 FR 72899 - Draft Guidance for Industry on Registration for Human Drug Compounding Outsourcing Facilities...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-04

... facilities. The draft guidance discusses the process for registration of outsourcing facilities. The draft... outsourcing facilities that will participate in the process. Estimated reporting burden until September 30...] Draft Guidance for Industry on Registration for Human Drug Compounding Outsourcing Facilities Under...

An Application of Business Process Management to Health Care Facilities.

PubMed

Hassan, Mohsen M D

The purpose of this article is to help health care facility managers and personnel identify significant elements of their facilities to address, and steps and actions to follow, when applying business process management to them. The ABPMP (Association of Business Process Management Professionals) life-cycle model of business process management is adopted, and steps from Lean, business process reengineering, and Six Sigma, and actions from operations management are presented to implement it. Managers of health care facilities can find in business process management a more comprehensive approach to improving their facilities than Lean, Six Sigma, business process reengineering, and ad hoc approaches that does not conflict with them because many of their elements can be included under its umbrella. Furthermore, the suggested application of business process management can guide and relieve them from selecting among these approaches, as well as provide them with specific steps and actions that they can follow. This article fills a gap in the literature by presenting a much needed comprehensive application of business process management to health care facilities that has specific steps and actions for implementation.

Integration Process for Payloads in the Fluids and Combustion Facility

NASA Technical Reports Server (NTRS)

Free, James M.; Nall, Marsha M.

2001-01-01

The Fluids and Combustion Facility (FCF) is an ISS research facility located in the United States Laboratory (US Lab), Destiny. The FCF is a multi-discipline facility that performs microgravity research primarily in fluids physics science and combustion science. This facility remains on-orbit and provides accommodations to multi-user and Principal investigator (PI) unique hardware. The FCF is designed to accommodate 15 PI's per year. In order to allow for this number of payloads per year, the FCF has developed an end-to-end analytical and physical integration process. The process includes provision of integration tools, products and interface management throughout the life of the payload. The payload is provided with a single point of contact from the facility and works with that interface from PI selection through post flight processing. The process utilizes electronic tools for creation of interface documents/agreements, storage of payload data and rollup for facility submittals to ISS. Additionally, the process provides integration to and testing with flight-like simulators prior to payload delivery to KSC. These simulators allow the payload to test in the flight configuration and perform final facility interface and science verifications. The process also provides for support to the payload from the FCF through the Payload Safety Review Panel (PSRP). Finally, the process includes support in the development of operational products and the operation of the payload on-orbit.

Monitoring agricultural processing electrical energy use and efficiency

USDA-ARS?s Scientific Manuscript database

Energy costs have become proportionately larger as cotton post-harvest processing facilities have utilized other inputs more efficiently. A discrepancy in energy consumption per unit processed between facilities suggests that energy could be utilized more efficiently. Cotton gin facilities were in...

KSC-2014-4149

NASA Image and Video Library

2014-09-25

CAPE CANAVERAL, Fla. – Coupled Florida East Coast Railway, or FEC, locomotives No. 433 and No. 428 make the first run past the Orbiter Processing Facility and Thermal Protection System Facility in Launch Complex 39 at NASA’s Kennedy Space Center in Florida during the Rail Vibration Test for the Canaveral Port Authority. Seismic monitors are collecting data as the train passes by. The purpose of the test is to collect amplitude, frequency and vibration test data utilizing two Florida East Coast locomotives operating on KSC tracks to ensure that future railroad operations will not affect launch vehicle processing at the center. Buildings instrumented for the test include the Rotation Processing Surge Facility, Thermal Protection Systems Facility, Vehicle Assembly Building, Orbiter Processing Facility and Booster Fabrication Facility. Photo credit: NASA/Daniel Casper

10 CFR 1016.9 - Processing security facility approval.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Processing security facility approval. 1016.9 Section 1016... § 1016.9 Processing security facility approval. The following receipt of an acceptable request for... granted pursuant to § 1016.6 of this part. ...

10 CFR 1016.9 - Processing security facility approval.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Processing security facility approval. 1016.9 Section 1016... § 1016.9 Processing security facility approval. The following receipt of an acceptable request for... granted pursuant to § 1016.6 of this part. ...

Kennedy Space Center Launch and Landing Support

NASA Technical Reports Server (NTRS)

Wahlberg, Jennifer

2010-01-01

The presentations describes Kennedy Space Center (KSC) payload processing, facilities and capabilities, and research development and life science experience. Topics include launch site processing, payload processing, key launch site processing roles, leveraging KSC experience, Space Station Processing Facility and capabilities, Baseline Data Collection Facility, Space Life Sciences Laboratory and capabilities, research payload development, International Space Station research flight hardware, KSC flight payload history, and KSC life science expertise.

77 FR 24700 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-25

... Process Facilities and Hydrochloric Acid Regeneration Plants (Renewal) AGENCY: Environmental Protection...: NESHAP for Steel Pickling, HCl Process Facilities and Hydrochloric Acid Regeneration Plants (Renewal...: Steel pickling, HCl process facilities and hydrochloric acid regeneration plants. Estimated Number of...

40 CFR 60.480a - Applicability and designation of affected facility.

Code of Federal Regulations, 2010 CFR

2010-07-01

... process improvement which is accomplished without a capital expenditure shall not by itself be considered...) within a process unit is an affected facility. (b) Any affected facility under paragraph (a) of this... “process unit” in § 60.481a of this subpart. While the definition of “process unit” is stayed, owners or...

Overview of NORM and activities by a NORM licensed permanent decontamination and waste processing facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mirro, G.A.

1997-02-01

This paper presents an overview of issues related to handling NORM materials, and provides a description of a facility designed for the processing of NORM contaminated equipment. With regard to handling NORM materials the author discusses sources of NORM, problems, regulations and disposal options, potential hazards, safety equipment, and issues related to personnel protection. For the facility, the author discusses: description of the permanent facility; the operations of the facility; the license it has for handling specific radioactive material; operating and safety procedures; decontamination facilities on site; NORM waste processing capabilities; and offsite NORM services which are available.

TEMPUS: A facility for containerless electromagnetic processing onboard spacelab

NASA Technical Reports Server (NTRS)

Lenski, H.; Willnecker, R.

1990-01-01

The electromagnetic containerless processing facility TEMPUS was recently assigned for a flight on the IML-2 mission. In comparison to the TEMPUS facility already flown on a sounding rocket, several improvements had to be implemented. These are in particular related to: safety; resource management; and the possibility to process different samples with different requirements in one mission. The basic design of this facility as well as the expected processing capabilities are presented. Two operational aspects turned out to strongly influence the facility design: control of the sample motion (first experimental results indicate that crew or ground interaction will be necessary to minimize residual sample motions during processing); and exchange of RF-coils (during processing in vacuum, evaporated sample materials will condense at the cold surface and may force a coil exchange, when a critical thickness is exceeded).

Mock Target Window OTR and IR Design and Testing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wass, Alexander Joseph

In order to fully verify temperature measurements made on the target window using infrared (IR) optical non-contact methods, actual comparative measurements are made with a real beam distribution as the heat source using Argonne National Laboratory’s (ANL) 35 MeV electron accelerator. Using Monte Carlo N-Particle (MCNP) simulations and thermal Finite Element Analysis (FEA), a cooled mock target window with thermocouple implants is designed to be used in such a test to achieve window temperatures up to 700°C. An uncoated and blackcoated mock window is designed to enhance the IR temperature measurements and verify optical transmitted radiation (OTR) imagery. This allowsmore » us to fully verify and characterize our temperature accuracy with our current IR camera method and any future method we may wish to explore using actual production conditions. This test also provides us with valuable conclusions/concerns regarding the calibration method we developed using our IR test stand at TA-53 in MPF-14.« less

A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle

PubMed Central

Xiao, Shuo; Coppeta, Jonathan R.; Rogers, Hunter B.; Isenberg, Brett C.; Zhu, Jie; Olalekan, Susan A.; McKinnon, Kelly E.; Dokic, Danijela; Rashedi, Alexandra S.; Haisenleder, Daniel J.; Malpani, Saurabh S.; Arnold-Murray, Chanel A.; Chen, Kuanwei; Jiang, Mingyang; Bai, Lu; Nguyen, Catherine T.; Zhang, Jiyang; Laronda, Monica M.; Hope, Thomas J.; Maniar, Kruti P.; Pavone, Mary Ellen; Avram, Michael J.; Sefton, Elizabeth C.; Getsios, Spiro; Burdette, Joanna E.; Kim, J. Julie; Borenstein, Jeffrey T.; Woodruff, Teresa K.

2017-01-01

The endocrine system dynamically controls tissue differentiation and homeostasis, but has not been studied using dynamic tissue culture paradigms. Here we show that a microfluidic system supports murine ovarian follicles to produce the human 28-day menstrual cycle hormone profile, which controls human female reproductive tract and peripheral tissue dynamics in single, dual and multiple unit microfluidic platforms (Solo-MFP, Duet-MFP and Quintet-MPF, respectively). These systems simulate the in vivo female reproductive tract and the endocrine loops between organ modules for the ovary, fallopian tube, uterus, cervix and liver, with a sustained circulating flow between all tissues. The reproductive tract tissues and peripheral organs integrated into a microfluidic platform, termed EVATAR, represents a powerful new in vitro tool that allows organ–organ integration of hormonal signalling as a phenocopy of menstrual cycle and pregnancy-like endocrine loops and has great potential to be used in drug discovery and toxicology studies. PMID:28350383

Microinjection of recombinant O-GlcNAc transferase potentiates Xenopus oocytes M-phase entry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dehennaut, Vanessa; EA 4020, Laboratoire de Regulation des Signaux de Division, USTL, IFR147, Villeneuve d'Ascq; Hanoulle, Xavier

2008-05-02

In order to understand the importance of the cytosolic and nuclear-specific O-linked N-acetylglucosaminylation (O-GlcNAc) on cell cycle regulation, we recently reported that inhibition of O-GlcNAc transferase (OGT) delayed or blocked Xenopus laevis oocyte germinal vesicle breakdown (GVBD). Here, we show that increased levels of the long OGT isoform (ncOGT) accelerate X. laevis oocyte GVBD. A N-terminally truncated isoform (sOGT) with a similar in vitro catalytic activity towards a synthetic CKII-derived peptide had no effect, illustrating the important role played by the N-terminal tetratrico-peptide repeats. ncOGT microinjection in the oocytes increases both the speed and extent of O-GlcNAc addition, leads tomore » a quicker activation of the MPF and MAPK pathways and finally results in a faster GVBD. Microinjection of anti-OGT antibodies leads to a delay of the GVBD kinetics. Our results hence demonstrate that OGT is a key molecule for the timely progression of the cell cycle.« less

Novel programmable microwave photonic filter with arbitrary filtering shape and linear phase.

PubMed

Zhu, Xiaoqi; Chen, Feiya; Peng, Huanfa; Chen, Zhangyuan

2017-04-17

We propose and demonstrate a novel optical frequency comb (OFC) based microwave photonic filter which is able to realize arbitrary filtering shape with linear phase response. The shape of filter response is software programmable using finite impulse response (FIR) filter design method. By shaping the OFC spectrum using a programmable waveshaper, we can realize designed amplitude of FIR taps. Positive and negative sign of FIR taps are achieved by balanced photo-detection. The double sideband (DSB) modulation and symmetric distribution of filter taps are used to maintain the linear phase condition. In the experiment, we realize a fully programmable filter in the range from DC to 13.88 GHz. Four basic types of filters (lowpass, highpass, bandpass and bandstop) with different bandwidths, cut-off frequencies and central frequencies are generated. Also a triple-passband filter is realized in our experiment. To the best of our knowledge, it is the first demonstration of a programmable multiple passband MPF with linear phase response. The experiment shows good agreement with the theoretical result.

Muscle fatigue in the temporal and masseter muscles in patients with temporomandibular dysfunction.

PubMed

Woźniak, Krzysztof; Lipski, Mariusz; Lichota, Damian; Szyszka-Sommerfeld, Liliana

2015-01-01

The aim of this study is to evaluate muscle fatigue in the temporal and masseter muscles in patients with temporomandibular dysfunction (TMD). Two hundred volunteers aged 19.3 to 27.8 years (mean 21.50, SD 0.97) participated in this study. Electromyographical (EMG) recordings were performed using a DAB-Bluetooth Instrument (Zebris Medical GmbH, Germany). Muscle fatigue was evaluated on the basis of a maximum effort test. The test was performed during a 10-second maximum isometric contraction (MVC) of the jaws. An analysis of changes in the mean power frequency of the two pairs of temporal and masseter muscles (MPF%) revealed significant differences in the groups of patients with varying degrees of temporomandibular disorders according to Di (P < 0.0000). The study showed an increase in the muscle fatigue of the temporal and masseter muscles correlated with the intensity of temporomandibular dysfunction symptoms in patients. The use of surface electromyography in assessing muscle fatigue is an excellent diagnostic tool for identifying patients with temporomandibular dysfunction.

A review of MRI evaluation of demyelination in cuprizone murine model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Krutenkova, E., E-mail: len--k@yandex.ru; Pan, E.; Khodanovich, M., E-mail: khodanovich@mail.tsu.ru

The cuprizone mouse model of non-autoimmune demyelination reproduces some phenomena of multiple sclerosis and is appropriate for validation and specification of a new method of non-invasive diagnostics. In the review new data which are collected using the new MRI method are compared with one or more conventional MRI tools. Also the paper reviewed the validation of MRI approaches using histological or immunohistochemical methods. Luxol fast blue histological staining and myelin basic protein immunostaining is widespread. To improve the accuracy of non-invasive conventional MRI, multimodal scanning could be applied. The new quantitative MRI method of fast mapping of the macromolecular protonmore » fraction is a reliable biomarker of myelin in the brain and can be used for research of demyelination in animals. To date, a validation of MPF method on the CPZ mouse model of demyelination is not performed, although this method is probably the best way to evaluate demyelination using MRI.« less

Suppression of Rayleigh backscattering noise using cascaded-SOA and microwave photonic filter for 10 Gb/s loop-back WDM-PON.

PubMed

Feng, Hanlin; Ge, Jia; Xiao, Shilin; Fok, Mable P

2014-05-19

In this paper, we present a novel Rayleigh backscattering (RB) noise mitigation scheme based on central carrier suppression for 10 Gb/s loop-back wavelength division multiplexing passive optical network (WDM-PON). Microwave modulated multi-subcarrier optical signal is used as downstream seeding light, while cascaded semiconductor optical amplifier (SOA) are used in the optical network unit (ONU) for suppressing the central carrier of the multi-subcarrier upstream signal. With central carrier suppression, interference generated by carrier RB noise at low frequency region is eliminated successfully. Transmission performance over 45 km single mode fiber (SMF) is studied experimentally, and the optical-signal-to-Rayleigh-noise-ratio (OSRNR) can be reduced to 15 dB with central carrier suppression ratio (CCSR) of 21 dB. Receiver sensitivity is further improved by 6 dB with the use of microwave photonic filter (MPF) for suppressing residual upstream microwave signal and residual carrier RB at high frequency region.

Annual reduction of solar UV exposure to the facial area of outdoor workers in Southeast Queensland by wearing a hat.

PubMed

Wong, J C; Airey, D K; Fleming, R A

1996-06-01

The total annual exposure to erythemally effective UVR was estimated for average work situations in a high exposure environment, viz, farm workers in Southeast Queensland (27.5 degrees S), and the effect of hat usage was examined. If no sun protection is used, the annual erythema exposures for this group of workers at three facial sites forehead, nose and cheek are 40, 57 and 34 J.cm-2 respectively. If a hat is worn throughout the year, the exposures are reduced to 6, 19 and 20 J.cm-2, respectively. The mean ratio of exposure without the hat to that with the hat (mean protection factor, MPF) was found to be 6 for the forehead, 3 for the nose and 2 for the cheek. The risk of non-melanoma skin cancers without the protection of the hat is estimated to increase by up to 100 times for basal cell carcinomas and 13 times for squamous cell carcinomas for a whole year of exposure.

Muscle Fatigue in the Temporal and Masseter Muscles in Patients with Temporomandibular Dysfunction

PubMed Central

Woźniak, Krzysztof; Lipski, Mariusz; Lichota, Damian

2015-01-01

The aim of this study is to evaluate muscle fatigue in the temporal and masseter muscles in patients with temporomandibular dysfunction (TMD). Two hundred volunteers aged 19.3 to 27.8 years (mean 21.50, SD 0.97) participated in this study. Electromyographical (EMG) recordings were performed using a DAB-Bluetooth Instrument (Zebris Medical GmbH, Germany). Muscle fatigue was evaluated on the basis of a maximum effort test. The test was performed during a 10-second maximum isometric contraction (MVC) of the jaws. An analysis of changes in the mean power frequency of the two pairs of temporal and masseter muscles (MPF%) revealed significant differences in the groups of patients with varying degrees of temporomandibular disorders according to Di (P < 0.0000). The study showed an increase in the muscle fatigue of the temporal and masseter muscles correlated with the intensity of temporomandibular dysfunction symptoms in patients. The use of surface electromyography in assessing muscle fatigue is an excellent diagnostic tool for identifying patients with temporomandibular dysfunction. PMID:25883949

The emergence of care facilities in Thailand for older German-speaking people: structural backgrounds and facility operators as transnational actors.

PubMed

Bender, Désirée; Hollstein, Tina; Schweppe, Cornelia

2017-12-01

This paper presents findings from an ethnographic study of old age care facilities for German-speaking people in Thailand. It analyses the conditions and processes behind the development and specific designs of such facilities. It first looks at the intertwinement, at the socio-structural level, of different transborder developments in which the facilities' emergence is embedded. Second, it analyses the processes that accompany the emergence, development and organisation of these facilities at the local level. In this regard, it points out the central role of the facility operators as transnational actors who mediate between different frames of reference and groups of actors involved in these facilities. It concludes that the processes of mediation and intertwining are an important and distinctive feature of the emergence of these facilities, necessitated by the fact that, although the facilities are located in Thailand, their 'markets' are in the German-speaking countries of their target groups.

76 FR 44049 - Guidance for Fuel Cycle Facility Change Processes

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-22

... NUCLEAR REGULATORY COMMISSION [NRC-2009-0262] Guidance for Fuel Cycle Facility Change Processes...-issued Draft Regulatory Guide, DG- 3037, ``Guidance for Fuel Cycle Facility Change Processes'' in the...-3037 from August 12, 2011 to September 16, 2011. DG-3037 describes the types of changes for fuel cycle...

EOS MLS Science Data Processing System: A Description of Architecture and Capabilities

NASA Technical Reports Server (NTRS)

Cuddy, David T.; Echeverri, Mark D.; Wagner, Paul A.; Hanzel, Audrey T.; Fuller, Ryan A.

2006-01-01

This paper describes the architecture and capabilities of the Science Data Processing System (SDPS) for the EOS MLS. The SDPS consists of two major components--the Science Computing Facility and the Science Investigator-led Processing System. The Science Computing Facility provides the facilities for the EOS MLS Science Team to perform the functions of scientific algorithm development, processing software development, quality control of data products, and scientific analyses. The Science Investigator-led Processing System processes and reprocesses the science data for the entire mission and delivers the data products to the Science Computing Facility and to the Goddard Space Flight Center Earth Science Distributed Active Archive Center, which archives and distributes the standard science products.

Facility design consideration for continuous mix production of class 1.3 propellant

NASA Technical Reports Server (NTRS)

Williamson, K. L.; Schirk, P. G.

1994-01-01

In November of 1989, NASA awarded the Advanced Solid Rocket Motor (ASRM) contract to Lockheed Missiles and Space Company (LMSC) for production of advanced solid rocket motors using the continuous mix process. Aerojet ASRM division (AAD) was selected as the facility operator and RUST International Corporation provided the engineering, procurement, and construction management services. The continuous mix process mandates that the mix and cast facilities be 'close-coupled' along with the premix facilities, creating unique and challenging requirements for the facility designer. The classical approach to handling energetic materials-division into manageable quantities, segregation, and isolation-was not available due to these process requirements and quantities involved. This paper provides a description of the physical facilities, the continuous mix process, and discusses the monitoring and detection techniques used to mitigate hazards and prevent an incident.

Development and Validation of Pathogen Environmental Monitoring Programs for Small Cheese Processing Facilities.

PubMed

Beno, Sarah M; Stasiewicz, Matthew J; Andrus, Alexis D; Ralyea, Robert D; Kent, David J; Martin, Nicole H; Wiedmann, Martin; Boor, Kathryn J

2016-12-01

Pathogen environmental monitoring programs (EMPs) are essential for food processing facilities of all sizes that produce ready-to-eat food products exposed to the processing environment. We developed, implemented, and evaluated EMPs targeting Listeria spp. and Salmonella in nine small cheese processing facilities, including seven farmstead facilities. Individual EMPs with monthly sample collection protocols were designed specifically for each facility. Salmonella was detected in only one facility, with likely introduction from the adjacent farm indicated by pulsed-field gel electrophoresis data. Listeria spp. were isolated from all nine facilities during routine sampling. The overall Listeria spp. (other than Listeria monocytogenes ) and L. monocytogenes prevalences in the 4,430 environmental samples collected were 6.03 and 1.35%, respectively. Molecular characterization and subtyping data suggested persistence of a given Listeria spp. strain in seven facilities and persistence of L. monocytogenes in four facilities. To assess routine sampling plans, validation sampling for Listeria spp. was performed in seven facilities after at least 6 months of routine sampling. This validation sampling was performed by independent individuals and included collection of 50 to 150 samples per facility, based on statistical sample size calculations. Two of the facilities had a significantly higher frequency of detection of Listeria spp. during the validation sampling than during routine sampling, whereas two other facilities had significantly lower frequencies of detection. This study provides a model for a science- and statistics-based approach to developing and validating pathogen EMPs.

Charter School Facilities: A Resource Guide on Development and Financing.

ERIC Educational Resources Information Center

Jakubowski, Lara

This manual provides information to help charter schools navigate the facility development process, including worksheets that can be customized to suit a particular school's needs. Sections cover how facility planning fits into business planning for charter schools, review a process for assessing a school's facility needs, and summarize how to…

40 CFR 60.630 - Applicability and designation of affected facility.

Code of Federal Regulations, 2010 CFR

2010-07-01

... process improvement that is accomplished without a capital expenditure shall not by itself be considered a... process unit is an affected facility. (b) Any affected facility under paragraph (a) of this section that...

NRL Review - 2009

DTIC Science & Technology

2009-01-01

for a fundamental physical understanding of electronic properties . The Materials Processing Facility includes appa- ratuses for powder production by...situ. Facilities to process powder into bulk specimens by hot and cold isostatic pressing permit a variety of consolidation possibilities. The iso...Synthesis/ Property Measurement Facility has special emphasis on polymers, surface-film processing , and directed self-assembly. The Chemical Vapor

10 CFR 1016.8 - Approval for processing access permittees for security facility approval.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Approval for processing access permittees for security facility approval. 1016.8 Section 1016.8 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) SAFEGUARDING OF RESTRICTED DATA Physical Security § 1016.8 Approval for processing access permittees for security facility...

10 CFR 1016.8 - Approval for processing access permittees for security facility approval.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Approval for processing access permittees for security facility approval. 1016.8 Section 1016.8 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) SAFEGUARDING OF RESTRICTED DATA Physical Security § 1016.8 Approval for processing access permittees for security facility...

The Facilities Audit. A Process for Improving Facilities Conditions.

ERIC Educational Resources Information Center

Kaiser, Harvey H.

The problems of deferred maintenance and decaying campus infrastructure have troubled higher education for the past two decades. This book, designed to be a tool for facilities managers, describes a process for inspecting and reporting conditions of buildings and infrastructure. The audit process is meant to be a routine part of maintenance…

A Review of the Aging Process and Facilities Topic.

PubMed

Jornitz, Maik W

2015-01-01

Aging facilities have become a concern in the pharmaceutical and biopharmaceutical manufacturing industry, so much that task forces are formed by trade organizations to address the topic. Too often, examples of aging or obsolete equipment, unit operations, processes, or entire facilities have been encountered. Major contributors to this outcome are the failure to invest in new equipment, disregarding appropriate maintenance activities, and neglecting the implementation of modern technologies. In some cases, a production process is insufficiently modified to manufacture a new product in an existing process that was used to produce a phased-out product. In other instances, manufacturers expanded the facility or processes to fulfill increasing demand and the scaling occurred in a non-uniform manner, which led to non-optimal results. Regulatory hurdles of post-approval changes in the process may thwart companies' efforts to implement new technologies. As an example, some changes have required 4 years to gain global approval. This paper will address cases of aging processes and facilities aside from modernizing options. © PDA, Inc. 2015.

Comparisons of social interaction and activities of daily living between long-term care facility and community-dwelling stroke patients.

PubMed

Yoon, Jeong-Ae; Park, Se-Gwan; Roh, Hyo-Lyun

2015-10-01

[Purpose] This study was conducted to compare the correlation between social interaction and activities of daily living (ADL) between community-dwelling and long-term care facility stroke patients. [Subjects and Methods] The Subjects were 65 chronic stroke patients (32 facility-residing, 33 community-dwelling). The Evaluation Social Interaction (ESI) tool was used to evaluate social interaction and the Assessment of Motor and Process Skills (AMPS) measure was used to evaluate ADL. [Results] Both social interaction and ADL were higher in community-dwelling than facility-residing stroke patients. There was a correlation between ESI and ADL for both motor and process skills among facility-residing patients, while only ADL process skills and ESI correlated among community-dwelling patients. In a partial correlation analysis using ADL motor and process skills as control variables, only process skills correlated with ESI. [Conclusion] For rehabilitation of stroke patients, an extended treatment process that combines ADL and social activities is likely to be required. Furthermore, treatment programs and institutional systems that can improve social interaction and promote health maintenance for community-dwelling and facility-residing chronic stroke patients are needed throughout the rehabilitation process.

Evaluation of the antipsychotic medication review process at four long-term facilities in Alberta.

PubMed

Birney, Arden; Charland, Paola; Cole, Mollie; Aslam Arain, Mubashir

2016-01-01

The goal of this evaluation was to understand how four long-term care (LTC) facilities in Alberta have implemented medication reviews for the Appropriate Use of Antipsychotics (AUA) initiative. We aimed to determine how interprofessional (IP) collaboration was incorporated in the antipsychotic medication reviews and how the reviews had been sustained. Four LTC facilities in Alberta participated in this evaluation. We conducted semistructured interviews with 18 facility staff and observed one antipsychotic medication review at each facility. We analyzed data according to the following key components that we identified as relevant to the antipsychotic medication reviews: the structure of the reviews, IP interactions between the staff members, and strategies for sustaining the reviews. The duration of antipsychotic medication reviews ranged from 1 to 1.5 hours. The number of professions in attendance ranged from 3 to 9; a pharmacist led the review at two sites, while a registered nurse led the review at one site and a nurse practitioner at the remaining site. The number of residents discussed during the review ranged from 6 to 20. The process at some facilities was highly IP, demonstrating each of the six IP competencies. Other facilities conducted the review in a less IP manner due to challenges of physician involvement and staff workload, particularly of health care aides. Facilities that had an nurse practitioner on site were more efficient with the process of implementing recommendations resulting from the medication reviews. The LTC facilities were successful in implementing the medication review process and the process seemed to be sustainable. A few challenges were observed in the implementation process at two facilities. IP practice moved forward the goals of the AUA initiative to reduce the inappropriate use of antipsychotics.

CANISTER HANDLING FACILITY DESCRIPTION DOCUMENT

DOE Office of Scientific and Technical Information (OSTI.GOV)

J.F. Beesley

The purpose of this facility description document (FDD) is to establish requirements and associated bases that drive the design of the Canister Handling Facility (CHF), which will allow the design effort to proceed to license application. This FDD will be revised at strategic points as the design matures. This FDD identifies the requirements and describes the facility design, as it currently exists, with emphasis on attributes of the design provided to meet the requirements. This FDD is an engineering tool for design control; accordingly, the primary audience and users are design engineers. This FDD is part of an iterative designmore » process. It leads the design process with regard to the flowdown of upper tier requirements onto the facility. Knowledge of these requirements is essential in performing the design process. The FDD follows the design with regard to the description of the facility. The description provided in this FDD reflects the current results of the design process.« less

Defense Waste Processing Facility Process Enhancements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bricker, Jonathan

2010-11-01

Jonathan Bricker provides an overview of process enhancements currently being done at the Defense Waste Processing Facility (DWPF) at SRS. Some of these enhancements include: melter bubblers; reduction in water use, and alternate reductant.

Project C-018H, 242-A Evaporator/PUREX Plant Process Condensate Treatment Facility, functional design criteria. Revision 3

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sullivan, N.

1995-05-02

This document provides the Functional Design Criteria (FDC) for Project C-018H, the 242-A Evaporator and Plutonium-Uranium Extraction (PUREX) Plant Condensate Treatment Facility (Also referred to as the 200 Area Effluent Treatment Facility [ETF]). The project will provide the facilities to treat and dispose of the 242-A Evaporator process condensate (PC), the Plutonium-Uranium Extraction (PUREX) Plant process condensate (PDD), and the PUREX Plant ammonia scrubber distillate (ASD).

Cutting the Cost of New Community College Facilities: Streamlining the Facilities Approval Process. Commission on Innovation Policy Discussion Paper Number 3.

ERIC Educational Resources Information Center

BW Associates, Berkeley, CA.

Intended to provide background information and preliminary options for the California Community Colleges' Commission on Innovation, this document proposes that approval processes for new facilities be simplified and that restrictions on the lease or purchase of off-campus facilities be eased. Following introductory materials detailing the…

An engine awaits processing in the new engine shop at KSC

NASA Technical Reports Server (NTRS)

1998-01-01

A new Block 2A engine awaits processing in the low bay of the Space Shuttle Main Engine Processing Facility (SSMEPF). Officially opened on July 6, the new facility replaces the Shuttle Main Engine Shop. The SSMEPF is an addition to the existing Orbiter Processing Facility Bay 3. The engine is scheduled to fly on the Space Shuttle Endeavour during the STS-88 mission in December 1998.

40 CFR 60.590 - Applicability and designation of affected facility.

Code of Federal Regulations, 2010 CFR

2010-07-01

... or replacement of equipment (defined in § 60.591) for the purpose of process improvement which is... in § 60.591) within a process unit is an affected facility. (b) Any affected facility under paragraph... “process unit” in § 60.590 of this subpart until the EPA takes final action to require compliance and...

40 CFR 60.590a - Applicability and designation of affected facility.

Code of Federal Regulations, 2010 CFR

2010-07-01

... of process improvement which is accomplished without a capital expenditure shall not by itself be... process unit is an affected facility. (b) Any affected facility under paragraph (a) of this section that... operators are not required to comply with the definition of “process unit” in § 60.590 of this subpart until...

7 CFR Appendix C to Subpart E of... - Guidelines for Loan Guarantees for Alcohol Fuel Production Facilities

Code of Federal Regulations, 2010 CFR

2010-01-01

... facilities necessary for the production and storage of alcohol and the processing of the by-products of alcohol production. The intent is to limit the alcohol and by-products processing facilities to those... alcohol or by-products in another manufacturing process, are not considered part of the alcohol production...

Cows are not mice: the role of cyclic AMP, phosphodiesterases, and adenosine monophosphate-activated protein kinase in the maintenance of meiotic arrest in bovine oocytes.

PubMed

Bilodeau-Goeseels, Sylvie

2011-01-01

Meiotic maturation in mammalian oocytes is initiated during fetal development, and is then arrested at the dictyate stage - possibly for several years. Oocyte meiosis resumes in preovulatory follicles in response to the lutenizing hormone (LH) surge or spontaneously when competent oocytes are removed from follicles and cultured. The mechanisms involved in meiotic arrest and resumption in bovine oocytes are not fully understood, and several studies point to important differences between oocytes from rodent and livestock species. This paper reviews earlier and contemporary studies on the effects of cAMP-elevating agents and phosphodiesterase (PDE) enzyme inhibitors on the maintenance of meiotic arrest in bovine oocytes in vitro. Contrary to results obtained with mouse oocytes, bovine oocyte meiosis is inhibited by activators of the energy sensor adenosine monophosphate-activated protein kinase (AMPK, mammalian gene PRKA), which is activated by AMP, the degradation product of cAMP. It is not clear whether or not the effects were due to AMPK activation, and they may depend on culture conditions. Evidence suggests that other signaling pathways (for example, the cGMP/nitric oxide pathway) are involved in bovine oocyte meiotic arrest, but further studies are needed to understand the interactions between the signaling pathways that lead to maturation promoting factor (MPF) being inactive or active. An improved understanding of the mechanisms involved in the control of bovine oocyte meiosis will facilitate better control of the process in vitro, resulting in increased developmental competence and increased efficiency of in vitro embryo production procedures. Copyright © 2011 Wiley Periodicals, Inc.

Involvement of GABAA receptor in Bufo arenarum oocyte maturation.

PubMed

Toranzo, G Sánchez; Zelarayán, L; Bonilla, F; Oterino, J; Bühler, M I

2008-05-01

Amphibian oocytes meiotic arrest is released under the stimulus of progesterone; this hormone interacts with the oocyte surface and starts a cascade of events leading to the activation of a cytoplasmic maturation promoting factor (MPF) that induces germinal vesicle breakdown (GVBD), chromosome condensation and extrusion of the first polar body. The aim of this work was to determine whether the activation of a GABAA receptor is able to induce GVBD in fully grown denuded oocytes of Bufo arenarum and to analyse its possible participation in progesterone-induced maturation. We also evaluated the role of purines and phospholipids in the maturation process induced by a GABAA receptor agonist such as muscimol. Our results indicated that the activation of the GABAA receptor by muscimol induces maturation in a dose- and time-dependent manner and that this activation is a genuine maturation that enables oocytes to form pronuclei. Assays with a receptor antagonist, picrotoxine, showed that the maturation induced by muscimol was inhibited. Treatment with picrotoxine, however, shows that the participation of GABAA receptor in progesterone-induced maturation is not significant. In addition, our results indicate that high intracellular levels of purines obtained by the use of db-AMPc and theophylline or the inhibition of the phosphatidylinositol 4,5-bisphosphate (PIP2 hydrolysis by neomycin and PIP2 turn over by LiCl, respectively, inhibited the maturation induced by muscimol. Treatment with H-7 indicated, however, that PKC activation is not necessary for GVBD induced by the GABAA receptor agonist. Results suggest that the transduction pathway used by the GABAA receptor to induce maturation is different from those used by progesterone.

Does increased postural threat lead to more conscious control of posture?

PubMed

Huffman, J L; Horslen, B C; Carpenter, M G; Adkin, A L

2009-11-01

Although it is well established that postural threat modifies postural control, little is known regarding the underlying mechanism(s) responsible for these changes. It is possible that changes in postural control under conditions of elevated postural threat result from a shift to a more conscious control of posture. The purpose of this study was to determine the influence of elevated postural threat on conscious control of posture and to determine the relationship between conscious control and postural control measures. Forty-eight healthy young adults stood on a force plate at two different surface heights: ground level (LOW) and 3.2-m above ground level (HIGH). Centre of pressure measures calculated in the anterior-posterior (AP) direction were mean position (AP-MP), root mean square (AP-RMS) and mean power frequency (AP-MPF). A modified state-specific version of the Movement Specific Reinvestment Scale was used to measure conscious motor processing (CMP) and movement self-consciousness (MSC). Balance confidence, fear of falling, perceived stability, and perceived and actual anxiety indicators were also collected. A significant effect of postural threat was found for movement reinvestment as participants reported more conscious control and a greater concern about their posture at the HIGH height. Significant correlations between CMP and MSC with AP-MP were observed as participants who consciously controlled and were more concerned for their posture leaned further away from the platform edge. It is possible that changes in movement reinvestment can influence specific aspects of posture (leaning) but other aspects may be immune to these changes (amplitude and frequency).

Strategic facility planning improves capital decision making.

PubMed

Reeve, J R

2001-03-01

A large, Midwestern IDS undertook a strategic facility-planning process to evaluate its facility portfolio and determine how best to allocate future investments in facility development. The IDS assembled a facility-planning team, which initiated the planning process with a market analysis to determine future market demands and identify service areas that warranted facility expansion. The team then analyzed each of the IDS's facilities from the perspective of uniform capacity measurements, highest and best use compared with needs, building condition and investment-worthiness, and facility growth and site development opportunities. Based on results of the analysis, the strategy adopted entailed, in part, shifting some space from inpatient care to ambulatory care services and demolishing and replacing the 11 percent of facilities deemed to be in the worst condition.

Assisted living and nursing homes: apples and oranges?

PubMed

Zimmerman, Sheryl; Gruber-Baldini, Ann L; Sloane, Philip D; Eckert, J Kevin; Hebel, J Richard; Morgan, Leslie A; Stearns, Sally C; Wildfire, Judith; Magaziner, Jay; Chen, Cory; Konrad, Thomas R

2003-04-01

The goals of this study are to describe the current state of residential care/assisted living (RC/AL) care and residents in comparison with nursing home (NH) care and residents, identify different types of RC/AL care and residents, and consider how variation in RC/AL case-mix reflects differences in care provision and/or consumer preference. Data were derived from the Collaborative Studies of Long-Term Care, a four-state study of 193 RC/AL facilities and 40 NHs. Multivariate analyses examined differences in ten process of care measures between RC/AL facilities with less than 16 beds; traditional RC/AL with 16 or more beds; new-model RC/AL; and NHs. Generalized estimating equation models determined differences in resident case-mix across RC/AL facilities using data for 2,078 residents. NHs report provision of significantly more health services and have significantly more lenient admission policies than RC/AL facilities, but provide less privacy. They do not differ from larger RC/AL facilities in policy clarity or resident control. Differences within RC/AL types are evident, with smaller and for-profit facilities scoring lower than other facilities across multiple process measures, including those related to individual freedom and institutional order. Resident impairment is substantial in both NHs and RC/AL settings, but differs by RC/AL facility characteristics. Differences in process of care and resident characteristics by facility type highlight the importance of considering: (1) the adequacy of existing process measures for evaluating smaller facilities; (2) resident case-mix when comparing facility types and outcomes; and (3) the complexity of understanding the implication of the process of care, given the importance of person-environment fit. Work is continuing to clarify the role of RC/AL vis-à-vis NHs in our nation's system of residential long-term care.

Hazardous Materials Verification and Limited Characterization Report on Sodium and Caustic Residuals in Materials and Fuel Complex Facilities MFC-799/799A

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gary Mecham

2010-08-01

This report is a companion to the Facilities Condition and Hazard Assessment for Materials and Fuel Complex Sodium Processing Facilities MFC-799/799A and Nuclear Calibration Laboratory MFC-770C (referred to as the Facilities Condition and Hazards Assessment). This report specifically responds to the requirement of Section 9.2, Item 6, of the Facilities Condition and Hazards Assessment to provide an updated assessment and verification of the residual hazardous materials remaining in the Sodium Processing Facilities processing system. The hazardous materials of concern are sodium and sodium hydroxide (caustic). The information supplied in this report supports the end-point objectives identified in the Transition Planmore » for Multiple Facilities at the Materials and Fuels Complex, Advanced Test Reactor, Central Facilities Area, and Power Burst Facility, as well as the deactivation and decommissioning critical decision milestone 1, as specified in U.S. Department of Energy Guide 413.3-8, “Environmental Management Cleanup Projects.” Using a tailored approach and based on information obtained through a combination of process knowledge, emergency management hazardous assessment documentation, and visual inspection, this report provides sufficient detail regarding the quantity of hazardous materials for the purposes of facility transfer; it also provides that further characterization/verification of these materials is unnecessary.« less

NASA-sponsored containerless processing experiments

NASA Technical Reports Server (NTRS)

Hofmeister, William H.

1990-01-01

An outline is presented of containerless processing and facilities at Intersonics which is sponsored by NASA. There are electromagnetic, acoustic, and aerodynamic levitation facilities. There are also laser beam and arc lamp heating systems along with state of the art noncontact temperature and optical property measurement facilities. Nonintrusive diagnostic techniques with Laser Induced Fluorescence and mass spectrometer are also available. Controlled atmosphere processing, gas quenching, and proven microgravity processing technology is part of the Intersonics capabilities.

Data Management Facility Operations Plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keck, Nicole N

2014-06-30

The Data Management Facility (DMF) is the data center that houses several critical Atmospheric Radiation Measurement (ARM) Climate Research Facility services, including first-level data processing for the ARM Mobile Facilities (AMFs), Eastern North Atlantic (ENA), North Slope of Alaska (NSA), Southern Great Plains (SGP), and Tropical Western Pacific (TWP) sites, as well as Value-Added Product (VAP) processing, development systems, and other network services.

Insect pest management decisions in food processing facilities

USDA-ARS?s Scientific Manuscript database

Pest management decision making in food processing facilities such as flour mills, rice mills, human and pet food manufacturing facilities, distribution centers and warehouses, and retail stores is a challenging undertaking. Insect pest management programs require an understanding of the food facili...

Lessons learned from the Siting Process of an Interim Storage Facility in Spain - 12024

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lamolla, Meritxell Martell

2012-07-01

On 29 December 2009, the Spanish government launched a site selection process to host a centralised interim storage facility for spent fuel and high-level radioactive waste. It was an unprecedented call for voluntarism among Spanish municipalities to site a controversial facility. Two nuclear municipalities, amongst a total of thirteen municipalities from five different regions, presented their candidatures to host the facility in their territories. For two years the government did not make a decision. Only in November 30, 2011, the new government elected on 20 November 2011 officially selected a non-nuclear municipality, Villar de Canas, for hosting this facility. Thismore » paper focuses on analysing the factors facilitating and hindering the siting of controversial facilities, in particular the interim storage facility in Spain. It demonstrates that involving all stakeholders in the decision-making process should not be underestimated. In the case of Spain, all regional governments where there were candidate municipalities willing to host the centralised interim storage facility, publicly opposed to the siting of the facility. (author)« less

Satellite remote sensing facility for oceanograhic applications

NASA Technical Reports Server (NTRS)

Evans, R. H.; Kent, S. S.; Seidman, J. B.

1980-01-01

The project organization, design process, and construction of a Remote Sensing Facility at Scripps Institution of Oceanography at LaJolla, California are described. The facility is capable of receiving, processing, and displaying oceanographic data received from satellites. Data are primarily imaging data representing the multispectral ocean emissions and reflectances, and are accumulated during 8 to 10 minute satellite passes over the California coast. The most important feature of the facility is the reception and processing of satellite data in real time, allowing investigators to direct ships to areas of interest for on-site verifications and experiments.

Cold Vacuum Drying facility civil structural system design description (SYS 06)

DOE Office of Scientific and Technical Information (OSTI.GOV)

PITKOFF, C.C.

This document describes the Cold Vacuum Drying (CVD) Facility civil - structural system. This system consists of the facility structure, including the administrative and process areas. The system's primary purpose is to provide for a facility to house the CVD process and personnel and to provide a tertiary level of containment. The document provides a description of the facility and demonstrates how the design meets the various requirements imposed by the safety analysis report and the design requirements document.

Adverse event reporting in Czech long-term care facilities.

PubMed

Hěib, Zdenřk; Vychytil, Pavel; Marx, David

2013-04-01

To describe adverse event reporting processes in long-term care facilities in the Czech Republic. Prospective cohort study involving a written questionnaire followed by in-person structured interviews with selected respondents. Long-term care facilities located in the Czech Republic. Staff of 111 long-term care facilities (87% of long-term care facilities in the Czech Republic). None. Sixty-three percent of long-term health-care facilities in the Czech Republic have adverse event-reporting processes already established, but these were frequently very immature programs sometimes consisting only of paper recording of incidents. Compared to questionnaire responses, in-person interview responses only partially tended to confirm the results of the written survey. Twenty-one facilities (33%) had at most 1 unconfirmed response, 31 facilities (49%) had 2 or 3 unconfirmed responses and the remaining 11 facilities (17%) had 4 or more unconfirmed responses. In-person interviews suggest that use of a written questionnaire to assess the adverse event-reporting process may have limited validity. Staff of the facilities we studied expressed an understanding of the importance of adverse event reporting and prevention, but interviews also suggested a lack of knowledge necessary for establishing a good institutional reporting system in long-term care.

Critical Protection Item classification for a waste processing facility at Savannah River Site

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ades, M.J.; Garrett, R.J.

1993-10-01

This paper describes the methodology for Critical Protection Item (CPI) classification and its application to the Structures, Systems and Components (SSC) of a waste processing facility at the Savannah River Site (SRS). The WSRC methodology for CPI classification includes the evaluation of the radiological and non-radiological consequences resulting from postulated accidents at the waste processing facility and comparison of these consequences with allowable limits. The types of accidents considered include explosions and fire in the facility and postulated accidents due to natural phenomena, including earthquakes, tornadoes, and high velocity straight winds. The radiological analysis results indicate that CPIs are notmore » required at the waste processing facility to mitigate the consequences of radiological release. The non-radiological analysis, however, shows that the Waste Storage Tank (WST) and the dike spill containment structures around the formic acid tanks in the cold chemical feed area and waste treatment area of the facility should be identified as CPIs. Accident mitigation options are provided and discussed.« less

A continuous silicon-coating facility

NASA Technical Reports Server (NTRS)

Butter, C.; Heaps, J. D.

1979-01-01

Automatic continuous silicon-coating facility is used to process 100 by 10 cm graphite-coated ceramic substrates for silicon solar cells. Process reduces contamination associated with conventional dip-coating processes, improving material service life.

Building Information Modeling (BIM) Primer. Report 1: Facility Life-Cycle Process and Technology Innovation

DTIC Science & Technology

2012-08-01

Building Information Modeling ( BIM ) Primer Report 1: Facility Life-cycle Process and Technology Innovation In fo...is unlimited. ERDC/ITL TR-12-2 August 2012 Building Information Modeling ( BIM ) Primer Report 1: Facility Life-cycle Process and Technology...and to enhance the quality of projects through the design, construction, and handover phases. Building Information Modeling ( BIM ) is a

Spacelab Data Processing Facility (SLDPF) quality assurance expert systems development

NASA Technical Reports Server (NTRS)

Kelly, Angelita C.; Basile, Lisa; Ames, Troy; Watson, Janice; Dallam, William

1987-01-01

Spacelab Data Processing Facility (SLDPF) expert system prototypes were developed to assist in the quality assurance of Spacelab and/or Attached Shuttle Payload (ASP) processed telemetry data. The SLDPF functions include the capturing, quality monitoring, processing, accounting, and forwarding of mission data to various user facilities. Prototypes for the two SLDPF functional elements, the Spacelab Output Processing System and the Spacelab Input Processing Element, are described. The prototypes have produced beneficial results including an increase in analyst productivity, a decrease in the burden of tedious analyses, the consistent evaluation of data, and the providing of concise historical records.

Spacelab Data Processing Facility (SLDPF) quality assurance expert systems development

NASA Technical Reports Server (NTRS)

Kelly, Angelita C.; Basile, Lisa; Ames, Troy; Watson, Janice; Dallam, William

1987-01-01

Spacelab Data Processing Facility (SLDPF) expert system prototypes have been developed to assist in the quality assurance of Spacelab and/or Attached Shuttle Payload (ASP) processed telemetry data. SLDPF functions include the capturing, quality monitoring, processing, accounting, and forwarding of mission data to various user facilities. Prototypes for the two SLDPF functional elements, the Spacelab Output Processing System and the Spacelab Input Processing Element, are described. The prototypes have produced beneficial results including an increase in analyst productivity, a decrease in the burden of tedious analyses, the consistent evaluation of data, and the providing of concise historical records.

Training practices of cell processing laboratory staff: analysis of a survey by the Alliance for Harmonization of Cellular Therapy Accreditation.

PubMed

Keever-Taylor, Carolyn A; Slaper-Cortenbach, Ineke; Celluzzi, Christina; Loper, Kathy; Aljurf, Mahmoud; Schwartz, Joseph; Mcgrath, Eoin; Eldridge, Paul

2015-12-01

Methods for processing products used for hematopoietic progenitor cell (HPC) transplantation must ensure their safety and efficacy. Personnel training and ongoing competency assessment is critical to this goal. Here we present results from a global survey of methods used by a diverse array of cell processing facilities for the initial training and ongoing competency assessment of key personnel. The Alliance for Harmonisation of Cellular Therapy Accreditation (AHCTA) created a survey to identify facility type, location, activity, personnel, and methods used for training and competency. A survey link was disseminated through organizations represented in AHCTA to processing facilities worldwide. Responses were tabulated and analyzed as a percentage of total responses and as a percentage of response by region group. Most facilities were based at academic medical centers or hospitals. Facilities with a broad range of activity, product sources and processing procedures were represented. Facilities reported using a combination of training and competency methods. However, some methods predominated. Cellular sources for training differed for training versus competency and also differed based on frequency of procedures performed. Most facilities had responsibilities for procedures in addition to processing for which training and competency methods differed. Although regional variation was observed, training and competency requirements were generally consistent. Survey data showed the use of a variety of training and competency methods but some methods predominated, suggesting their utility. These results could help new and established facilities in making decisions for their own training and competency programs. Copyright © 2015 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.

State Requirements for Educational Facilities, 1999.

ERIC Educational Resources Information Center

Florida State Dept. of Education, Tallahassee. Office of Educational Facilities.

This updated, two-volume document provides guidance for those involved in the educational facilities procurement process, and includes recent legislative changes affecting the state of Florida's building code. The first volume is organized by the sequence of steps required in the facilities procurement process and presents state requirements for…

Research and the planned Space Experiment Research and Processing Laboratory

NASA Technical Reports Server (NTRS)

2000-01-01

Researchers perform tests at Kennedy Space Center. New facilities for such research will be provided at the Space Experiment Research Procession Laboratory (SERPL). The SERPL is a planned 100,000-square-foot laboratory that will provide expanded and upgraded facilities for hosting International Space Station experiment processing. In addition, it will provide better support for other biological and life sciences payload processing at KSC. It will serve as a magnet facility for a planned 400-acre Space Station Commerce Park.

Extraterrestrial processing and manufacturing of large space systems. Volume 3: Executive summary

NASA Technical Reports Server (NTRS)

Miller, R. H.; Smith, D. B. S.

1979-01-01

Facilities and equipment are defined for refining processes to commercial grade of lunar material that is delivered to a 'space manufacturing facility' in beneficiated, primary processed quality. The manufacturing facilities and the equipment for producing elements of large space systems from these materials and providing programmatic assessments of the concepts are also defined. In-space production processes of solar cells (by vapor deposition) and arrays, structures and joints, conduits, waveguides, RF equipment radiators, wire cables, converters, and others are described.

The SSMEPF opens with a ribbon-cutting ceremony

NASA Technical Reports Server (NTRS)

1998-01-01

Participants in the ribbon cutting for KSC's new 34,600-square- foot Space Shuttle Main Engine Processing Facility (SSMEPF) gather to talk inside the facility following the ceremony. From left, they are Robert B. Sieck, director of Shuttle Processing; KSC Center Director Roy D. Bridges Jr.; U.S. Congressman Dave Weldon; John Plowden, vice president of Rocketdyne; and Donald R. McMonagle, manager of Launch Integration. A major addition to the existing Orbiter Processing Facility Bay 3, the SSMEPF replaces the Shuttle Main Engine Shop located in the Vehicle Assembly Building (VAB). The decision to move the shop out of the VAB was prompted by safety considerations and recent engine processing improvements. The first three main engines to be processed in the new facility will fly on Shuttle Endeavour's STS-88 mission in December 1998.

Baseline process description for simulating plutonium oxide production for precalc project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pike, J. A.

Savannah River National Laboratory (SRNL) started a multi-year project, the PreCalc Project, to develop a computational simulation of a plutonium oxide (PuO 2) production facility with the objective to study the fundamental relationships between morphological and physicochemical properties. This report provides a detailed baseline process description to be used by SRNL personnel and collaborators to facilitate the initial design and construction of the simulation. The PreCalc Project team selected the HB-Line Plutonium Finishing Facility as the basis for a nominal baseline process since the facility is operational and significant model validation data can be obtained. The process boundary as wellmore » as process and facility design details necessary for multi-scale, multi-physics models are provided.« less

Advanced technologies for maintenance of electrical systems and equipment at the Savannah River Site Defense Waste Processing Facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Husler, R.O.; Weir, T.J.

1991-01-01

An enhanced maintenance program is being established to characterize and monitor cables, components, and process response at the Savannah River Site, Defense Waste Processing Facility. This facility was designed and constructed to immobilize the radioactive waste currently stored in underground storage tanks and is expected to begin operation in 1993. The plant is initiating the program to baseline and monitor instrument and control (I C) and electrical equipment, remote process equipment, embedded instrument and control cables, and in-cell jumper cables used in the facility. This program is based on the electronic characterization and diagnostic (ECAD) system which was modified tomore » include process response analysis and to meet rigid Department of Energy equipment requirements. The system consists of computer-automated, state-of-the-art electronics. The data that are gathered are stored in a computerized database for analysis, trending, and troubleshooting. It is anticipated that the data which are gathered and trended will aid in life extension for the facility.« less

Advanced technologies for maintenance of electrical systems and equipment at the Savannah River Site Defense Waste Processing Facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Husler, R.O.; Weir, T.J.

1991-12-31

An enhanced maintenance program is being established to characterize and monitor cables, components, and process response at the Savannah River Site, Defense Waste Processing Facility. This facility was designed and constructed to immobilize the radioactive waste currently stored in underground storage tanks and is expected to begin operation in 1993. The plant is initiating the program to baseline and monitor instrument and control (I&C) and electrical equipment, remote process equipment, embedded instrument and control cables, and in-cell jumper cables used in the facility. This program is based on the electronic characterization and diagnostic (ECAD) system which was modified to includemore » process response analysis and to meet rigid Department of Energy equipment requirements. The system consists of computer-automated, state-of-the-art electronics. The data that are gathered are stored in a computerized database for analysis, trending, and troubleshooting. It is anticipated that the data which are gathered and trended will aid in life extension for the facility.« less

Space Station Freedom: A foothold on the future

NASA Technical Reports Server (NTRS)

1989-01-01

An overview of the Space Station Freedom is given. Its modules are discussed and illustrated along with its microgravity research facilities. These facilities include the advanced protein crystal growth facility, the containerless processing facility, a furnace facility, a combustion facility, and a fluid physics/dynamics facility. The topic of living in space is also addressed.

Hazardous Waste Cleanup: Frontier Chemical Waste Process Incorporated – Royal Avenue Site in Niagara Falls, New York

EPA Pesticide Factsheets

Frontier Chemical Waste Process facility is located in a heavy industrial/commercial area. Several large industrial facilities surround the facility. The closest residential area is located about ½ mile west and the closest off-site building is located 300

75 FR 55988 - Approval and Promulgation of Implementation Plans; Commonwealth of Kentucky; Prevention of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-15

... exclude facilities that produce ethanol through a natural fermentation process from the definition of... action on Kentucky's provisions to exclude facilities that produce ethanol through a natural fermentation... facilities that produce ethanol through a natural fermentation process from the definition of ``chemical...

KSC-2014-4140

NASA Image and Video Library

2014-09-25

CAPE CANAVERAL, Fla. – Coupled Florida East Coast Railway, or FEC, locomotives No. 433 and No. 428 pass the Vehicle Assembly Building in Launch Complex 39 at NASA’s Kennedy Space Center in Florida on their way to NASA's Locomotive Maintenance Facility. Kennedy's Center Planning and Development Directorate has enlisted the locomotives to support a Rail Vibration Test for the Canaveral Port Authority. The purpose of the test is to collect amplitude, frequency and vibration test data utilizing two Florida East Coast locomotives operating on KSC tracks to ensure that future railroad operations will not affect launch vehicle processing at the center. Buildings instrumented for the test include the Rotation Processing Surge Facility, Thermal Protection Systems Facility, Vehicle Assembly Building, Orbiter Processing Facility and Booster Fabrication Facility. Photo credit: NASA/Daniel Casper

Facilities | Bioenergy | NREL

Science.gov Websites

Facilities Facilities At NREL's state-of-the-art bioenergy research facilities, researchers design options. Photo of interior of industrial, two-story building with high-bay, piping, and large processing

Ground Handling of Batteries at Test and Launch-site Facilities

NASA Technical Reports Server (NTRS)

Jeevarajan, Judith A.; Hohl, Alan R.

2008-01-01

Ground handling of flight as well as engineering batteries at test facilities and launch-site facilities is a safety critical process. Test equipment interfacing with the batteries should have the required controls to prevent a hazardous failure of the batteries. Test equipment failures should not induce catastrophic failures on the batteries. Transportation requirements for batteries should also be taken into consideration for safe transportation. This viewgraph presentation includes information on the safe handling of batteries for ground processing at test facilities as well as launch-site facilities.

Radiographic trends of dental offices and dental schools.

PubMed

Suleiman, O H; Spelic, D C; Conway, B; Hart, J C; Boyce, P R; Antonsen, R G

1999-07-01

A survey of private practice facilities in the United States that perform dental radiography was conducted in 1993 and repeated in dental schools in 1995-1996. Both surveys were conducted as part of the Nationwide Evaluation of X-ray Trends, or NEXT, survey program. A representative sample of dental facilities from each participating state were surveyed, and data on patient radiation exposure, radiographic technique, film-image quality, film-processing quality and darkroom fog were collected. The authors found that dental schools use E-speed film more frequently than do private practice facilities. The use of E-speed film and better film processing by dental schools resulted in lower patient radiation exposures without sacrificing image quality. The authors also found that dental school darkrooms had lower ambient fog levels than did those of private practice facilities. The distribution for the 1993 NEXT survey facilities was greater than that observed for dental schools for radiation exposure, film-processing quality and darkroom fog. Dental schools, in general, had better film quality and lower radiation exposures than did private practice facilities. Facilities need to emphasize better quality processing and the use of E-speed film to reduce patient exposure and improve image quality.

Thermal Storage Process and Components Laboratory | Energy Systems

Science.gov Websites

Integration Facility | NREL Process and Components Laboratory Thermal Storage Process and Components Laboratory The Energy Systems Integration Facility's Thermal Systems Process and Components Laboratory supports research and development, testing, and evaluation of new thermal energy storage systems

Facilities Condition and Hazards Assessment for Materials and Fuel Complex Facilities MFC-799, 799A, and 770C

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gary Mecham; Don Konoyer

2009-11-01

The Materials & Fuel Complex (MFC) facilities 799 Sodium Processing Facility (a single building consisting of two areas: the Sodium Process Area (SPA) and the Carbonate Process Area (CPA), 799A Caustic Storage Area, and 770C Nuclear Calibration Laboratory have been declared excess to future Department of Energy mission requirements. Transfer of these facilities from Nuclear Energy to Environmental Management, and an associated schedule for doing so, have been agreed upon by the two offices. The prerequisites for this transfer to occur are the removal of nonexcess materials and chemical inventory, deinventory of the calibration source in MFC-770C, and the reroutingmore » and/or isolation of utility and service systems. This report provides a description of the current physical condition and any hazards (material, chemical, nuclear or occupational) that may be associated with past operations of these facilities. This information will document conditions at time of transfer of the facilities from Nuclear Energy to Environmental Management and serve as the basis for disposition planning. The process used in obtaining this information included document searches, interviews and facility walk-downs. A copy of the facility walk-down checklist is included in this report as Appendix A. MFC-799/799A/770C are all structurally sound and associated hazardous or potentially hazardous conditions are well defined and well understood. All installed equipment items (tanks, filters, etc.) used to process hazardous materials remain in place and appear to have maintained their integrity. There is no evidence of leakage and all openings are properly sealed or closed off and connections are sound. The pits appear clean with no evidence of cracking or deterioration that could lead to migration of contamination. Based upon the available information/documentation reviewed and the overall conditions observed during the facilities walk-down, it is concluded that these facilities may be disposed of at minimal risk to human health, safety or the environment.« less

Nuclear Waste: Defense Waste Processing Facility-Cost, Schedule, and Technical Issues.

DTIC Science & Technology

1992-06-17

gallons of high-level radioactive waste stored in underground tanks at the savannah major facility involved Is the Defense Waste Processing Facility ( DwPF ...As a result of concerns about potential problems with the DWPF and delays in its scheduled start-up, the Chairman of the Environment, Energy, and...Natural Resources Subcommittee, House Committee on Government Operations, asked GAO to review the status of the DWPF and other facilities. This report

A Pilot Assessment of Occupational Health Hazards in the US Electronic Scrap Recycling Industry

PubMed Central

Ceballos, Diana M.; Gong, Wei; Page, Elena

2015-01-01

The National Institute for Occupational Safety and Health (NIOSH) surveyed a randomly selected sample of electronic scrap (e-scrap) recycling facilities nationwide to characterize work processes, exposures, and controls. Despite multiple attempts to contact 278 facilities, only 47 responded (17% response rate). Surveyed facilities reported recycling a wide variety of electronics. The most common recycling processes were manual dismantling and sorting. Other processes included shredding, crushing, and automated separation. Many facilities reported that they had health and safety programs in place. However, some facilities reported the use of compressed air for cleaning, a practice that can lead to increased employee dust exposures, and some facilities allowed food and drinks in the production areas, a practice that can lead to ingestion of contaminants. Although our results may not be generalizable to all US e-scrap recycling facilities, they are informative regarding health and safety programs in the industry. We concluded that e-scrap recycling has the potential for a wide variety of occupational exposures particularly because of the frequent use of manual processes. On-site evaluations of e-scrap recyclers are needed to determine if reported work processes, practices, and controls are effective and meet current standards and guidelines. Educating the e-scrap recycling industry about health and safety best practices, specifically related to safe handling of metal dust, would help protect employees. PMID:25738822

A Pilot Assessment of Occupational Health Hazards in the US Electronic Scrap Recycling Industry.

PubMed

Ceballos, Diana M; Gong, Wei; Page, Elena

2015-01-01

The National Institute for Occupational Safety and Health (NIOSH) surveyed a randomly selected sample of electronic scrap (e-scrap) recycling facilities nationwide to characterize work processes, exposures, and controls. Despite multiple attempts to contact 278 facilities, only 47 responded (17% response rate). Surveyed facilities reported recycling a wide variety of electronics. The most common recycling processes were manual dismantling and sorting. Other processes included shredding, crushing, and automated separation. Many facilities reported that they had health and safety programs in place. However, some facilities reported the use of compressed air for cleaning, a practice that can lead to increased employee dust exposures, and some facilities allowed food and drinks in the production areas, a practice that can lead to ingestion of contaminants. Although our results may not be generalizable to all US e-scrap recycling facilities, they are informative regarding health and safety programs in the industry. We concluded that e-scrap recycling has the potential for a wide variety of occupational exposures particularly because of the frequent use of manual processes. On-site evaluations of e-scrap recyclers are needed to determine if reported work processes, practices, and controls are effective and meet current standards and guidelines. Educating the e-scrap recycling industry about health and safety best practices, specifically related to safe handling of metal dust, would help protect employees.

Quality of the delivery services in health facilities in Northern Ethiopia.

PubMed

Fisseha, Girmatsion; Berhane, Yemane; Worku, Alemayehu; Terefe, Wondwossen

2017-03-09

Substantial improvements have been observed in the coverage of and access to maternal health service, especially in skilled birth attendants, in Ethiopia. However, the quality of care has been lagging behind. Therefore, this study investigated the status of the quality of delivery services in Northern Ethiopia. A facility based survey was conducted from December 2014 to February 2015 in Northern Ethiopia. The quality of delivery service was assessed in 32 health facilities using a facility audit checklist, by reviewing delivery, by conducting in-depth interview and observation, and by conducting exit interviews with eligible mothers. Facilities were considered as 'good quality' if they scored positively on 75% of the quality indicators set in the national guidelines for all the three components; input (materials, infrastructure, and human resource), process (adherence to standard care procedures during intrapartum and immediate postpartum periods) and output (the mothers' satisfaction and utilization of lifesaving procedures). Overall 2 of 32 (6.3%) of the study facilities fulfilled all the three quality components; input, process and output. Two of the three components were assessed as good in 11 of the 32 (34.4%) health facilities. The input quality was the better of the other quality components; which was good in 21 out of the 32 (65.6%) health facilities. The process and output quality was good in only 10 of the 32 (31.3%) facilities. Only 6.3% of the studied health facilities had good quality in all three dimensions of quality measures that was done in accordance to the national delivery service guidelines. The most compromised quality component was the process. Systematic and sustained efforts need to be strengthened to improve all dimensions of quality in order to achieve the desired quality of delivery services and increase the proportion of births occurring in health facilities.

A Bridge over Troubled Water: Facility Needs for Inclusive Classrooms.

ERIC Educational Resources Information Center

Pierce, Judy; And Others

1993-01-01

Focuses on ways to meet the facility needs of students with disabilities in inclusive classrooms. Provides a definition of inclusion; discusses some processes to design school environments that support a side range of student needs; and presents a process that will enable facility planning teams to move all students from self-contained classrooms…

KENNEDY SPACE CENTER, FLA. - The Space Life Sciences Lab (SLSL), formerly known as the Space Experiment Research and Processing Laboratory (SERPL), is nearing completion. The new lab is a state-of-the-art facility being built for ISS biotechnology research. Developed as a partnership between NASA-KSC and the State of Florida, NASA’s life sciences contractor will be the primary tenant of the facility, leasing space to conduct flight experiment processing and NASA-sponsored research. About 20 percent of the facility will be available for use by Florida’s university researchers through the Florida Space Research Institute.

NASA Image and Video Library

2003-09-10

KENNEDY SPACE CENTER, FLA. - The Space Life Sciences Lab (SLSL), formerly known as the Space Experiment Research and Processing Laboratory (SERPL), is nearing completion. The new lab is a state-of-the-art facility being built for ISS biotechnology research. Developed as a partnership between NASA-KSC and the State of Florida, NASA’s life sciences contractor will be the primary tenant of the facility, leasing space to conduct flight experiment processing and NASA-sponsored research. About 20 percent of the facility will be available for use by Florida’s university researchers through the Florida Space Research Institute.

KSC-98pc786

NASA Image and Video Library

1998-07-06

James W. Tibble (pointing at engine), an Engine Systems/Ground Support Equipment team manager for Rocketdyne, discusses the operation of a Space Shuttle Main Engine with Robert B. Sieck, director of Shuttle Processing; U.S. Congressman Dave Weldon; and KSC Center Director Roy D. Bridges Jr. Following the ribbon cutting ceremony for KSC's new 34,600-square-foot Space Shuttle Main Engine Processing Facility (SSMEPF), KSC employees and media explored the facility. A major addition to the existing Orbiter Processing Facility Bay 3, the SSMEPF replaces the Shuttle Main Engine Shop located in the Vehicle Assembly Building (VAB). The decision to move the shop out of the VAB was prompted by safety considerations and recent engine processing improvements. The first three main engines to be processed in the new facility will fly on Shuttle Endeavour's STS-88 mission in December 1998

The SSMEPF opens with a ribbon-cutting ceremony

NASA Technical Reports Server (NTRS)

1998-01-01

James W. Tibble (pointing at engine), an Engine Systems/Ground Support Equipment team manager for Rocketdyne, discusses the operation of a Space Shuttle Main Engine with Robert B. Sieck, director of Shuttle Processing; U.S. Congressman Dave Weldon; and KSC Center Director Roy D. Bridges Jr. Following the ribbon cutting ceremony for KSC's new 34,600-square-foot Space Shuttle Main Engine Processing Facility (SSMEPF), KSC employees and media explored the facility. A major addition to the existing Orbiter Processing Facility Bay 3, the SSMEPF replaces the Shuttle Main Engine Shop located in the Vehicle Assembly Building (VAB). The decision to move the shop out of the VAB was prompted by safety considerations and recent engine processing improvements. The first three main engines to be processed in the new facility will fly on Shuttle Endeavour's STS-88 mission in December 1998.

Patellofemoral pain syndrome: electromyography in a frequency domain analysis

NASA Astrophysics Data System (ADS)

Catelli, D. S.; Kuriki, H. U.; Polito, L. F.; Azevedo, F. M.; Negrão Filho, R. F.; Alves, N.

2011-09-01

The Patellofemoral Pain Syndrome (PFPS), has a multifactorial etiology and affects approximately 7 to 15% of the population, mostly women, youth, adults and active persons. PFPS causes anterior or retropatelar pain that is exacerbated during functional motor gestures, such as up and down stairs or spending long periods of time sitting, squatting or kneeling. As the diagnostic evaluation of this syndrome is still indirect, different mechanisms and methodologies try to make a classification that distinguishes patients with PFPS in relation to asymptomatic. Thereby, the purpose of this investigation was to determine the characteristics of the electromyographic (EMG) signal in the frequency domain of the vastus medialis oblique (VMO) and vastus lateralis (VL) in patients with PFPS, during the ascent of stairs. 33 young women (22 control group and 11 PFPS group), were evaluated by EMG during ascent of stairs. The VMO mean power frequency (MPF) and the VL frequency 95% (F95) were lower in symptomatic individuals. This may be related to the difference in muscle recruitment strategy exerted by each muscle in the PFPS group compared to the control group.

Assessment of psychosocial risks faced by workers in Almería-type greenhouses, using the Mini Psychosocial Factor method.

PubMed

Montoya-García, M E; Callejón-Ferre, A J; Pérez-Alonso, J; Sánchez-Hermosilla, J

2013-03-01

This work reports the use of the Mini Psychosocial Factor (MPF) method for assessing the psychosocial risks faced by agricultural workers in the greenhouses of Almería (Spain) with the aim of improving their health. The variables Rhythm, Mobbing, Relationships, Health, Recognition, Autonomy, Emotional Involvement, Support, Compensation, Control, Demands, and Mental Load were recorded using a pre-validated questionnaire containing 15 questions. The sex, age, and nationality of the respondents (n = 310) were also recorded, as were the type of greenhouse in which each worked, the size of the greenhouse, and the crop grown. The results showed psychosocial risks to exist for the workers. Multiple correspondence analysis, however, showed that moderate risks can be offset by new prevention programmes that improve Spanish legislation in terms of workers' salaries, worker-employer social days, work timetables to facilitate family life, and training courses. This could improve the work environment and health of Almería's greenhouse workers as well as their productivity. Copyright © 2012 Elsevier Ltd and The Ergonomics Society. All rights reserved.

Socket welds in nuclear facilities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anderson, P.A.; Torres, L.L.

1995-12-31

Socket welds are easier and faster to make than are butt welds. However, they are often not used in nuclear facilities because the crevices between the pipes and the socket sleeves may be subject to crevice corrosion. If socket welds can be qualified for wider use in facilities that process nuclear materials, the radiation exposures to welders can be significantly reduced. The current tests at the Idaho Chemical Processing Plant (ICPP) are designed to determine if socket welds can be qualified for use in the waste processing system at a nuclear fuel processing plant.

40 CFR 408.165 - Standards of performance for new sources.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Hand-Butchered Salmon Processing Subcategory § 408.165 Standards of performance for new sources. (a... this subpart: (1) Any hand-butchered salmon processing facility located in population or processing... salmon processing facility not covered under § 408.165(a)(1) shall meet the following limitations: No...

40 CFR 408.162 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... CATEGORY Alaskan Hand-Butchered Salmon Processing Subcategory § 408.162 Effluent limitations guidelines... available (BPT): (a) Any hand-butchered salmon processing facility located in population or processing... salmon processing facility not covered under § 408.162(a) shall meet the following limitations: No...

40 CFR 408.165 - Standards of performance for new sources.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Hand-Butchered Salmon Processing Subcategory § 408.165 Standards of performance for new sources. (a... this subpart: (1) Any hand-butchered salmon processing facility located in population or processing... salmon processing facility not covered under § 408.165(a)(1) shall meet the following limitations: No...

40 CFR 408.162 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2011 CFR

2011-07-01

... CATEGORY Alaskan Hand-Butchered Salmon Processing Subcategory § 408.162 Effluent limitations guidelines... available (BPT): (a) Any hand-butchered salmon processing facility located in population or processing... salmon processing facility not covered under § 408.162(a) shall meet the following limitations: No...

10 CFR 70.64 - Requirements for new facilities or new processes at existing facilities.

Code of Federal Regulations, 2011 CFR

2011-01-01

... behavior of items relied on for safety. (b) Facility and system design and facility layout must be based on... existing facilities. (a) Baseline design criteria. Each prospective applicant or licensee shall address the following baseline design criteria in the design of new facilities. Each existing licensee shall address the...

10 CFR 70.64 - Requirements for new facilities or new processes at existing facilities.

Code of Federal Regulations, 2013 CFR

2013-01-01

... behavior of items relied on for safety. (b) Facility and system design and facility layout must be based on... existing facilities. (a) Baseline design criteria. Each prospective applicant or licensee shall address the following baseline design criteria in the design of new facilities. Each existing licensee shall address the...

10 CFR 70.64 - Requirements for new facilities or new processes at existing facilities.

Code of Federal Regulations, 2012 CFR

2012-01-01

... behavior of items relied on for safety. (b) Facility and system design and facility layout must be based on... existing facilities. (a) Baseline design criteria. Each prospective applicant or licensee shall address the following baseline design criteria in the design of new facilities. Each existing licensee shall address the...

10 CFR 70.64 - Requirements for new facilities or new processes at existing facilities.

Code of Federal Regulations, 2014 CFR

2014-01-01

... behavior of items relied on for safety. (b) Facility and system design and facility layout must be based on... existing facilities. (a) Baseline design criteria. Each prospective applicant or licensee shall address the following baseline design criteria in the design of new facilities. Each existing licensee shall address the...

KSC-98pc1166

NASA Image and Video Library

1998-09-28

The orbiter Atlantis, being towed from the Shuttle Landing Facility toward the Vehicle Assembly Building (VAB) , intersects the morning sun's rays. In the background, to the right of the VAB, are the Orbiter Processing Facility 1 and 2. Atlantis spent 10 months in Palmdale, CA, undergoing extensive inspections and modifications in the orbiter processing facility there. The modifications included several upgrades enabling it to support International Space Station missions, such as adding an external airlock for ISS docking missions and installing thinner, lighter thermal protection blankets for weight reduction which will allow it to haul heavier cargo. Atlantis will undergo preparations at KSC in Orbiter Processing Facility 2 for its planned flight in June 1999

Electromagnetic Interference/Compatibility (EMI/EMC) Control Test and Measurement Facility: User Test Planning Guide

NASA Technical Reports Server (NTRS)

Scully, Robert C.

2011-01-01

Test process, milestones and inputs are unknowns to first-time users of the EMI/EMC Test Facility. The User Test Planning Guide aids in establishing expectations for both NASA and non-NASA facility customers. The potential audience for this guide includes both internal and commercial spaceflight hardware/software developers. It is intended to assist their test engineering personnel in test planning and execution. Material covered includes a roadmap of the test process, roles and responsibilities of facility and user, major milestones, facility capabilities, and inputs required by the facility. Samples of deliverables, test article interfaces, and inputs necessary to define test scope, cost, and schedule are included as an appendix to the guide.

Manufacturing Planning Guide

NASA Technical Reports Server (NTRS)

Waid, Michael

2011-01-01

Manufacturing process, milestones and inputs are unknowns to first-time users of the manufacturing facilities. The Manufacturing Planning Guide aids in establishing expectations for both NASA and non-NASA facility customers. The potential audience for this guide includes both internal and commercial spaceflight hardware/software developers. It is intended to assist their project engineering personnel in manufacturing planning and execution. Material covered includes a roadmap of the manufacturing process, roles and responsibilities of facility and user, major milestones, facility capabilities, and inputs required by the facility. Samples of deliverables, products, and inputs necessary to define test scope, cost, and schedule are included as an appendix to the guide.

Fire Hazard Assessment in Supporting Fire Protection System Design of a Chemical Process Facility

DTIC Science & Technology

1996-08-01

CSDP/Studies/FireHaz –i– 3/28/97 FIRE HAZARD ASSESSMENT IN SUPPORTING FIRE PROTECTION SYSTEM DESIGN OF A CHEMICAL PROCESS FACILITY Ali Pezeshk...Joseph Chang, Dwight Hunt, and Peter Jahn Parsons Infrastructure & Technology Group, Inc. Pasadena, California 91124 ABSTRACT Because fires in a chemical ...Assessment in Supporting Fire Protection System Design of a Chemical Process Facility 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6

KSC-00padig019

NASA Image and Video Library

2000-05-02

Researchers perform tests at Kennedy Space Center. New facilities for such research will be provided at the Space Experiment Research Procession Laboratory (SERPL). The SERPL is a planned 100,000-square-foot laboratory that will provide expanded and upgraded facilities for hosting International Space Station experiment processing. In addition, it will provide better support for other biological and life sciences payload processing at KSC. It will serve as a magnet facility for a planned 400-acre Space Station Commerce Park

KSC00padig019

NASA Image and Video Library

2000-05-02

Researchers perform tests at Kennedy Space Center. New facilities for such research will be provided at the Space Experiment Research Procession Laboratory (SERPL). The SERPL is a planned 100,000-square-foot laboratory that will provide expanded and upgraded facilities for hosting International Space Station experiment processing. In addition, it will provide better support for other biological and life sciences payload processing at KSC. It will serve as a magnet facility for a planned 400-acre Space Station Commerce Park

Phased Demolition of an Occupied Facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brede, Lawrence M.; Lauterbach, Merl J.; Witt, Brandon W.

2008-01-15

The U.S. government constructed the K-1401 facility in the late 1940's as a support building for various projects supporting the uranium gaseous diffusion process. In 2004 the U.S. Department of Energy authorized Bechtel Jacobs Company, LLC (BJC) to decontaminate and demolish the facility. The K-1401 facility was used for a variety of industrial purposes supporting the gaseous diffusion process. Many different substances were used to support these processes over the years and as a result different parts of the facility were contaminated with fluorine, chlorine trifluoride, uranium and technetium radiological contamination, asbestos, and mercury. The total facility area is 46,015more » m{sup 2} (495,000 sf) including a 6,800 m{sup 2} basement (73,200 sf). In addition to the contamination areas in the facility, a large portion was leased to businesses for re-industrialization when the D and D activities began. The work scope associated with the facility included purging and steam cleaning the former fluorine and chlorine trifluoride systems, decontaminating loose radiologically contaminated and mercury spill areas, dismantling former radiological lines contaminated with uranium oxide compounds and technetium, abating all asbestos containing material, and demolishing the facility. These various situations contributed to the challenge of successfully conducting D and D tasks on the facility. In order to efficiently utilize the work force, demolition equipment, and waste hauling trucks the normal approach of decontaminating the facility of the hazardous materials, and then conducting demolition in series required a project schedule of five years, which is not cost effective. The entire project was planned with continuous demolition as the goal end state. As a result, the first activities, Phase 1, required to prepare sections for demolition, including steam cleaning fluorine and chlorine trifluoride process lines in basement and facility asbestos abatement, were conducted while the tenants who were leasing floor space in the facility moved out. Upon completion of this phase the facility was turned over to the demolition project and the most hazardous materials were removed from the facility. Phase 2 activities included removing the process gas lines from sections C/D/E while decontaminating and preparing sections A and B for demolition. Demolition preparation activities include removing transit siding and universal waste from the area. Phase 3 began with demolition activities in sections A and B1 while continuing process gas line removal from sections C/D/E, as well as conducting demolition preparation activities to these sections. Area B was split into two sections, allowing demolition activities to occur in section B1 while personnel could still access the upper floor in sections C, D, and E. Once demolition began in section B2, personnel entry was only authorized in the basement. This timeline initiated phase 4, and the project completed cleaning the process components from the basement while section B2 demolition began. The final phase, phase 5, began once the basement was cleared. Final demolition activities began on sections C, D, E, and the basement. This material will ship for disposal and is scheduled for completion during FY07. Because the project was able to successfully phase demolition activities, the total facility demolition schedule was reduced by half to 2-1/2 years. The project was able to move portions of the demolition schedule from working in series to working in parallel, allowing the job to deliver facility demolition debris to ship for disposal 'just in time' as the facility was demolished.« less

40 CFR 60.5401 - What are the exceptions to the equipment leak standards for affected facilities at onshore...

Code of Federal Regulations, 2014 CFR

2014-07-01

... equipment leak standards for affected facilities at onshore natural gas processing plants? 60.5401 Section... for affected facilities at onshore natural gas processing plants? (a) You may comply with the... is detected. (4)(i) Any pressure relief device that is located in a nonfractionating plant that is...

40 CFR 60.5401 - What are the exceptions to the equipment leak standards for affected facilities at onshore...

Code of Federal Regulations, 2013 CFR

2013-07-01

... equipment leak standards for affected facilities at onshore natural gas processing plants? 60.5401 Section... for affected facilities at onshore natural gas processing plants? (a) You may comply with the... is detected. (4)(i) Any pressure relief device that is located in a nonfractionating plant that is...

18 CFR 157.21 - Pre-filing procedures and review process for LNG terminal facilities and other natural gas...

Code of Federal Regulations, 2011 CFR

2011-04-01

... and review process for LNG terminal facilities and other natural gas facilities prior to filing of... COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER NATURAL GAS ACT APPLICATIONS FOR CERTIFICATES OF PUBLIC CONVENIENCE AND NECESSITY AND FOR ORDERS PERMITTING AND APPROVING ABANDONMENT UNDER SECTION 7 OF THE NATURAL...

Providing security for automated process control systems at hydropower engineering facilities

NASA Astrophysics Data System (ADS)

Vasiliev, Y. S.; Zegzhda, P. D.; Zegzhda, D. P.

2016-12-01

This article suggests the concept of a cyberphysical system to manage computer security of automated process control systems at hydropower engineering facilities. According to the authors, this system consists of a set of information processing tools and computer-controlled physical devices. Examples of cyber attacks on power engineering facilities are provided, and a strategy of improving cybersecurity of hydropower engineering systems is suggested. The architecture of the multilevel protection of the automated process control system (APCS) of power engineering facilities is given, including security systems, control systems, access control, encryption, secure virtual private network of subsystems for monitoring and analysis of security events. The distinctive aspect of the approach is consideration of interrelations and cyber threats, arising when SCADA is integrated with the unified enterprise information system.

Containerless Processing Studies in the MSFC Electrostatic Levitator

NASA Technical Reports Server (NTRS)

Rogers, J. R.; SanSoucie, M. P.

2012-01-01

Levitation or containerless processing represents an important tool in materials research. Levitated specimens are free from contact with a container, which permits studies of deeply undercooled melts, and high-temperature, highly reactive materials. Containerless processing provides data for studies of thermophysical properties, phase equilibria, metastable state formation, microstructure formation, undercooling, and nucleation. Levitation techniques include: acoustic, aero-acoustic, electromagnetic, and electrostatic. In microgravity, levitation can be achieved with greatly reduced positioning forces. Microgravity also reduces the effects of buoyancy and sedimentation in melts. The European Space Agency (ESA) and the German Aerospace Center (DLR) jointly developed an electromagnetic levitator facility (MSL-EML) for containerless materials processing in space. The MSL-EML will be accommodated in the European Columbus Facility on the International Space Station (ISS). The electrostatic levitator (ESL) facility at the Marshall Space Flight Center provides support for the development of containerless processing studies for the ISS. The capabilities of the facility and recent results will be discussed.

Development of experimental facilities for processing metallic crystals in orbit

NASA Technical Reports Server (NTRS)

Duncan, Bill J.

1990-01-01

This paper discusses the evolution, current status, and planning for facilities to exploit the microgravity environment of earth orbit in applied metallic materials science. Space-Shuttle based facilities and some precursor flight programs are reviewed. Current facility development programs and planned Space Station furnace capabilities are described. The reduced gravity levels available in earth orbit allow the processing of metallic materials without the disturbing influence of gravitationally induced thermal convection, stratification due to density differences in sample components, or the effects of hydrostatic pressure.

17 CFR 37.400 - Core Principle 4-Monitoring of trading and trade processing.

Code of Federal Regulations, 2014 CFR

2014-04-01

... trading and trade processing. 37.400 Section 37.400 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION SWAP EXECUTION FACILITIES Monitoring of Trading and Trade Processing § 37.400 Core Principle 4—Monitoring of trading and trade processing. The swap execution facility shall: (a) Establish and...

40 CFR 408.175 - Standards of performance for new sources.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Mechanized Salmon Processing Subcategory § 408.175 Standards of performance for new sources. (a) The...: (1) Any mechanized salmon processing facility located in population or processing centers including... grease 28 10 pH (1) (1) 1 Within the range 6.0 to 9.0. (2) Any mechanized salmon processing facility not...

40 CFR 408.175 - Standards of performance for new sources.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Mechanized Salmon Processing Subcategory § 408.175 Standards of performance for new sources. (a) The...: (1) Any mechanized salmon processing facility located in population or processing centers including... grease 28 10 pH (1) (1) 1 Within the range 6.0 to 9.0. (2) Any mechanized salmon processing facility not...

Downgrading Nuclear Facilities to Radiological Facilities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jarry, Jeffrey F.; Farr, Jesse Oscar; Duran, Leroy

2015-08-01

Based on inventory reductions and the use of alternate storage facilities, the Sandia National Laboratories (SNL) downgraded 4 SNL Hazard Category 3 (HC-3) nuclear facilities to less-than-HC-3 radiological facilities. SNL’s Waste Management and Pollution Prevention Department (WMPPD) managed the HC-3 nuclear facilities and implemented the downgrade. This paper will examine the downgrade process,

Anodal Transcranial Direct Current Stimulation Shows Minimal, Measure-Specific Effects on Dynamic Postural Control in Young and Older Adults: A Double Blind, Sham-Controlled Study

PubMed Central

Doumas, Michail

2017-01-01

We investigated whether stimulating the cerebellum and primary motor cortex (M1) using transcranial direct current stimulation (tDCS) could affect postural control in young and older adults. tDCS was employed using a double-blind, sham-controlled design, in which young (aged 18–35) and older adults (aged 65+) were assessed over three sessions, one for each stimulatory condition–M1, cerebellar and sham. The effect of tDCS on postural control was assessed using a sway-referencing paradigm, which induced platform rotations in proportion to the participant’s body sway, thus assessing sensory reweighting processes. Task difficulty was manipulated so that young adults experienced a support surface that was twice as compliant as that of older adults, in order to minimise baseline age differences in postural sway. Effects of tDCS on postural control were assessed during, immediately after and 30 minutes after tDCS. Additionally, the effect of tDCS on corticospinal excitability was measured by evaluating motor evoked potentials using transcranial magnetic stimulation immediately after and 30 minutes after tDCS. Minimal effects of tDCS on postural control were found in the eyes open condition only, and this was dependent on the measure assessed and age group. For young adults, stimulation had only offline effects, as cerebellar stimulation showed higher mean power frequency (MPF) of sway 30 minutes after stimulation. For older adults, both stimulation conditions delayed the increase in sway amplitude witnessed between blocks one and two until stimulation was no longer active. In conclusion, despite tDCS’ growing popularity, we would caution researchers to consider carefully the type of measures assessed and the groups targeted in tDCS studies of postural control. PMID:28099522

Anodal Transcranial Direct Current Stimulation Shows Minimal, Measure-Specific Effects on Dynamic Postural Control in Young and Older Adults: A Double Blind, Sham-Controlled Study.

PubMed

Craig, Chesney E; Doumas, Michail

2017-01-01

We investigated whether stimulating the cerebellum and primary motor cortex (M1) using transcranial direct current stimulation (tDCS) could affect postural control in young and older adults. tDCS was employed using a double-blind, sham-controlled design, in which young (aged 18-35) and older adults (aged 65+) were assessed over three sessions, one for each stimulatory condition-M1, cerebellar and sham. The effect of tDCS on postural control was assessed using a sway-referencing paradigm, which induced platform rotations in proportion to the participant's body sway, thus assessing sensory reweighting processes. Task difficulty was manipulated so that young adults experienced a support surface that was twice as compliant as that of older adults, in order to minimise baseline age differences in postural sway. Effects of tDCS on postural control were assessed during, immediately after and 30 minutes after tDCS. Additionally, the effect of tDCS on corticospinal excitability was measured by evaluating motor evoked potentials using transcranial magnetic stimulation immediately after and 30 minutes after tDCS. Minimal effects of tDCS on postural control were found in the eyes open condition only, and this was dependent on the measure assessed and age group. For young adults, stimulation had only offline effects, as cerebellar stimulation showed higher mean power frequency (MPF) of sway 30 minutes after stimulation. For older adults, both stimulation conditions delayed the increase in sway amplitude witnessed between blocks one and two until stimulation was no longer active. In conclusion, despite tDCS' growing popularity, we would caution researchers to consider carefully the type of measures assessed and the groups targeted in tDCS studies of postural control.

Preliminary hazards analysis -- vitrification process

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coordes, D.; Ruggieri, M.; Russell, J.

1994-06-01

This paper presents a Preliminary Hazards Analysis (PHA) for mixed waste vitrification by joule heating. The purpose of performing a PHA is to establish an initial hazard categorization for a DOE nuclear facility and to identify those processes and structures which may have an impact on or be important to safety. The PHA is typically performed during and provides input to project conceptual design. The PHA is then followed by a Preliminary Safety Analysis Report (PSAR) performed during Title 1 and 2 design. The PSAR then leads to performance of the Final Safety Analysis Report performed during the facility`s constructionmore » and testing. It should be completed before routine operation of the facility commences. This PHA addresses the first four chapters of the safety analysis process, in accordance with the requirements of DOE Safety Guidelines in SG 830.110. The hazards associated with vitrification processes are evaluated using standard safety analysis methods which include: identification of credible potential hazardous energy sources; identification of preventative features of the facility or system; identification of mitigative features; and analyses of credible hazards. Maximal facility inventories of radioactive and hazardous materials are postulated to evaluate worst case accident consequences. These inventories were based on DOE-STD-1027-92 guidance and the surrogate waste streams defined by Mayberry, et al. Radiological assessments indicate that a facility, depending on the radioactive material inventory, may be an exempt, Category 3, or Category 2 facility. The calculated impacts would result in no significant impact to offsite personnel or the environment. Hazardous materials assessment indicates that a Mixed Waste Vitrification facility will be a Low Hazard facility having minimal impacts to offsite personnel and the environment.« less

National Biomedical Tracer Facility: Project definition study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heaton, R.; Peterson, E.; Smith, P.

The Los Alamos National Laboratory is an ideal institution and New Mexico is an ideal location for siting the National Biomedical Tracer Facility (NBTF). The essence of the Los Alamos proposal is the development of two complementary irradiation facilities that combined with our existing radiochemical processing hot cell facilities and waste handling and disposal facilities provide a low cost alternative to other proposals that seek to satisfy the objectives of the NBTF. We propose the construction of a 30 MeV cyclotron facility at the site of the radiochemical facilities, and the construction of a 100 MeV target station at LAMPFmore » to satisfy the requirements and objectives of the NBTF. We do not require any modifications to our existing radiochemical processing hot cell facilities or our waste treatment and disposal facilities to accomplish the objectives of the NBTF. The total capital cost for the facility defined by the project definition study is $15.2 M. This cost estimate includes $9.9 M for the cyclotron and associated facility, $2.0 M for the 100 MeV target station at LAMPF, and $3.3 M for design.« less

MPF model ages of the Rembrandt basin and scarp system, Mercury.

NASA Astrophysics Data System (ADS)

Ferrari, Sabrina; Massironi, Matteo; Marchi, Simone; Byrne, Paul K.; Klimczak, Christian; Cremonese, Gabriele

2013-04-01

The 715-km-diameter Rembrandt basin is the largest well-preserved impact feature of the southern hemisphere of Mercury [1] (Fig. 1), and was imaged for the first time during the second flyby of the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) mission [2]. Much of the basin interior is covered by smooth, high-reflectance plains interpreted to be of volcanic origin [1-3] that host sets of contractional and extensional tectonic structures. Notably, Rembrandt basin and its smooth plains are cross-cut by a 1,000-km-long reverse fault system [1-5] that trends ~E-W, bending toward the north within the basin. The individual faults of this system accommodated crustal shortening that resulted from global contraction as Mercury's interior cooled [1]. The current shape of the reverse fault system may have been influenced by the formation of the Rembrandt basin [5]. The emplacement of the interior smooth plains predates both the basin-related tectonism and the final development of the giant scarp, which is suggestive of either short-lived volcanic activity immediately after basin formation or a later volcanic phase set against prolonged tectonic activity. In order to quantify the duration of volcanic and tectonic activity in and around Rembrandt basin, we determined the crater count-derived ages of the involved terrains by means of the Model Production Function (MPF) chronology of Mercury [6-8], which is rely on the knowledge of the impactors flux on the planet. Crater chronology allowed us to constrain the Rembrandt basin formation to the early Calorian period and a widespread resurfacing up to 3.5 Ga ago. The volcanic activity affected both the basin and its surroundings, but ended prior to some basin-related and regional faulting. Hence, if the giant scarp begun to develop even before the basin formation (as suggested by its length-displacement profile across the basin itself, [5]) the regional tectonic activity along this structure might have started even before the Late Heavy Bombardment period and lasted for more than 300 Ma, when the volcanic activity in this part of hermean surface was already accomplished. [1] Watters T. R. et al. (2009) Science, 324, 618. [2] Solomon S. C. et al. (2008) Science, 321, 59. [3] Denevi B. W. et al. (2009) Science, 324, 613. [4] Byrne P. K. et al. (2012) LPS, 43, abstract 1722. [5] Ferrari S. et al. (2012) EPSC, 7, abstract 2012-874. [6] Marchi S. et al. (2009) The Astron. Jour., 137, 4936. [7] Massironi M. et al. (2009) Geophys. Res. Lett., 36, L21204. [8] Marchi S. et al. (2011) Plaet. Space Sci., 59, 1968.

Mars Exploration Rover Landing Site Hectometer Slopes

NASA Astrophysics Data System (ADS)

Haldemann, A. F.; Anderson, F. S.

2002-12-01

The Mars Exploration Rover (MER) airbag landing system imposes a maximum slope of 5 degrees over 100 m length-scales. This limit avoids dangerous changes in elevation over the horizontal travel distance of the lander on its parachute between the time of the last radar altimeter detection of the surface and the time the retro-rockets fire and the bridle to the airbags is cut. Stereo imagery from the MGS MOC can provide information at this length scale, but MOC stereo coverage is sparse, even when targeted to MER landing sites. Additionally, MGS spacecraft stability issues affect the DEMs at precisely the hectometric length-scale1. The MOLA instrument provides global coverage pulse-width measurements2 over a single MOLA-pulse footprint, which is about 100 m in diameter. However, the pulse spread only provides an upper bound on the 100 m slope. We chose another approach. We sample the inter-pulse root-mean-square (RMS) height deviations for MOLA track segments restricted to pixels of 0.1 deg latitude by 0.1 deg longitude. Then, under the assumption of self-affine topography, we determine the scale-dependence of the RMS deviations and extrapolate that behavior over the range of 300 m to 1.2 km downward to the 100 m scale. Shepard et al.3 clearly summarize the statistical properties of the RMS deviation (noting that it also goes by the name structure function, variogram or Allan deviation), and we follow their nomenclature. The RMS deviation is a useful measure in that it can be directly converted to RMS-slope for a given length-scale. We map the results of this self-affine extrapolation method for each of the proposed MER landing sites as well as Viking Lander 1 (VL1) and Pathfiner (MPF). In order of decreasing average hectometer RMS-slopes, Melas (about 4.5 degrees) > Elysium EP80 > Gusev > MPF > Elysium EP78 > VL1 > Athabasca > Isidis > Hematite (about 1 degree). We also map the scaling parameter (Hurst exponent); its behavior in the MER landing site regions is interesting in how it ties together the regional behavior of kilometer slopes (directly measured with MOLA) with the decameter and meter slopes (locally derived from stereo image analysis or radar scattering). 1Kirk, R. L., E. Howington-Kraus, and B. A. Archinal, Int. Arch. Photogramm. Remote Sens., XXVIII(B4), 476 (CD-ROM), 2001; Kirk, R. L., E. Howington-Kraus, and B. A. Archinal, Lunar Planet Sci., XXXIII, abs 1988, 2002. 2Garvin, J. B., and J. J. Frawley, Lunar Planet. Sci., XXXI, abs 1884, 2000. 3Shepard, M. K., R. A. Brackett, and R. E. Arvidson, J. Geophys. Res., 100, 11709-11718, 1995.; Shepard, M. K., et al., J. Geophys. Res., 106, 32777-32796, 2001.

Melatonin accelerates maturation inducing hormone (MIH): induced oocyte maturation in carps.

PubMed

Chattoraj, Asamanja; Bhattacharyya, Sharmistha; Basu, Dipanjan; Bhattacharya, Shelley; Bhattacharya, Samir; Maitra, Saumen Kumar

2005-02-01

The present communication is an attempt to demonstrate the influence of melatonin on the action of maturation inducing hormone (MIH) on the maturation of oocytes in carps. The oocytes from gravid female major carp Labeo rohita were isolated and incubated separately in Medium 199 containing (a) only MIH (1 microg/ml), (b) only melatonin (at concentrations of 50, 100 or 500 pg/ml), and (c) both melatonin and MIH, but at different time intervals. In the latter group, melatonin was added to the incubating medium either (i) 4 h before addition of MIH, (ii) 2 h before addition of MIH, (iii) co-administered with MIH (0 h interval) or (iv) 2 h after addition of MIH. In each case, oocytes were further incubated for 4, 8, 12 or 16 h post- administration of MIH, and the effects of treatment on oocyte maturation were evaluated by considering the rate (%) of germinal vesicle breakdown (GVBD). Incubation of oocytes in a medium containing only melatonin did not result in GVBD of any oocyte. Nearly all the oocytes underwent GVBD when incubated with MIH for 16 h. Administration of melatonin along with MIH (at 0 h interval) or 2 h after addition of MIH did not result in any significant change in the rate of GVBD compared to that in a medium containing only MIH. However, it was quite interesting to observe that incubation of oocytes with melatonin especially 4 h prior to addition of MIH in the medium, led to an accelerated rate of GVBD in the oocytes. Experiments with the oocytes of another major carp Cyprinus carpio following an identical schedule depicted similar results except a difference in the optimum melatonin dose. In L. rohita, 50 pg/ml melatonin had maximum acceleratory effect on MIH-induced GVBD of oocytes, while it was 100 pg/ml in C. carpio. Further study revealed that pre-incubation with melatonin accelerates the action of MIH on the formation of a complex of two proteins (MPF), a regulatory component called cyclin B and the catalytic component protein kinase known as cyclin-dependent kinase, Cdk1. Densitometric analysis of the immunoblot data collected from the melatonin pre-treated MIH incubated oocytes showed that cyclin B level continued to increase even after 4 h of incubation, and reached the peak after 12 h. Moreover, determination of H1 kinase activity as an indicator of MPF activity in oocytes revealed that melatonin pre-incubation considerably increased MIH stimulation of histone H1 phosphorylation as compared to MIH alone. Thus, the present study demonstrates for the first time that prior incubation with melatonin accelerates the action of MIH on carp oocyte maturation.

KENNEDY SPACE CENTER, FLA. - NASA Manager Steve Cain explains aspects of Space Shuttle processing to Consul General of Japan Ko Kodaira and his family in the Orbiter Processing Facility during their visit to Kennedy Space Center (KSC). From left are Kodaira's wife Marie, his daughter Reiko, Kodaira, and Cain, Senior Future International Space Station Element Manager. Kodaira is touring the facilities at KSC at the invitation of the local office of the National Space Development Agency of Japan (NASDA) to acquaint him with KSC's unique processing capabilities.

NASA Image and Video Library

2003-08-26

KENNEDY SPACE CENTER, FLA. - NASA Manager Steve Cain explains aspects of Space Shuttle processing to Consul General of Japan Ko Kodaira and his family in the Orbiter Processing Facility during their visit to Kennedy Space Center (KSC). From left are Kodaira's wife Marie, his daughter Reiko, Kodaira, and Cain, Senior Future International Space Station Element Manager. Kodaira is touring the facilities at KSC at the invitation of the local office of the National Space Development Agency of Japan (NASDA) to acquaint him with KSC's unique processing capabilities.

Space Station Furnace Facility Core. Requirements definition and conceptual design study. Volume 2: Technical report. Appendix 6: Technical summary reports

NASA Technical Reports Server (NTRS)

1992-01-01

The Space Station Furnace Facility (SSFF) is a modular facility for materials research in the microgravity environment of the Space Station Freedom (SSF). The SSFF is designed for crystal growth and solidification research in the fields of electronic and photonic materials, metals and alloys, and glasses and ceramics and will allow for experimental determination of the role of gravitational forces in the solidification process. The facility will provide a capability for basic scientific research and will evaluate the commercial viability of low-gravity processing of selected technologically important materials. The facility is designed to support a complement of furnace modules as outlined in the Science Capabilities Requirements Document (SCRD). The SSFF is a three rack facility that provides the functions, interfaces, and equipment necessary for the processing of the furnaces and consists of two main parts: the SSFF Core Rack and the two Experiment Racks. The facility is designed to accommodate two experimenter-provided furnace modules housed within the two experiment racks, and is designed to operate these two furnace modules simultaneously. The SCRD specifies a wide range of furnace requirements and serves as the basis for the SSFF conceptual design. SSFF will support automated processing during the man-tended operations and is also designed for crew interface during the permanently manned configuration. The facility is modular in design and facilitates changes as required, so the SSFF is adept to modifications, maintenance, reconfiguration, and technology evolution.

40 CFR 240.207-3 - Recommended procedures: Operations.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) SOLID WASTES GUIDELINES FOR THE THERMAL PROCESSING OF SOLID WASTES Requirements and Recommended... appearance. (b) Solid wastes that cannot be processed by the facility should be removed from the facility at...

Antenna Test Facility (ATF): User Test Planning Guide

NASA Technical Reports Server (NTRS)

Lin, Greg

2011-01-01

Test process, milestones and inputs are unknowns to first-time users of the ATF. The User Test Planning Guide aids in establishing expectations for both NASA and non-NASA facility customers. The potential audience for this guide includes both internal and commercial spaceflight hardware/software developers. It is intended to assist their test engineering personnel in test planning and execution. Material covered includes a roadmap of the test process, roles and responsibilities of facility and user, major milestones, facility capabilities, and inputs required by the facility. Samples of deliverables, test article interfaces, and inputs necessary to define test scope, cost, and schedule are included as an appendix to the guide.

Radiant Heat Test Facility (RHTF): User Test Planning Guide

NASA Technical Reports Server (NTRS)

DelPapa, Steven

2011-01-01

Test process, milestones and inputs are unknowns to first-time users of the RHTF. The User Test Planning Guide aids in establishing expectations for both NASA and non- NASA facility customers. The potential audience for this guide includes both internal and commercial spaceflight hardware/software developers. It is intended to assist their test engineering personnel in test planning and execution. Material covered includes a roadmap of the test process, roles and responsibilities of facility and user, major milestones, facility capabilities, and inputs required by the facility. Samples of deliverables, test article interfaces, and inputs necessary to define test scope, cost, and schedule are included as an appendix to the guide.

Communication Systems Simulation Laboratory (CSSL): Simulation Planning Guide

NASA Technical Reports Server (NTRS)

Schlesinger, Adam

2012-01-01

The simulation process, milestones and inputs are unknowns to first-time users of the CSSL. The Simulation Planning Guide aids in establishing expectations for both NASA and non-NASA facility customers. The potential audience for this guide includes both internal and commercial spaceflight hardware/software developers. It is intended to assist their engineering personnel in simulation planning and execution. Material covered includes a roadmap of the simulation process, roles and responsibilities of facility and user, major milestones, facility capabilities, and inputs required by the facility. Samples of deliverables, facility interfaces, and inputs necessary to define scope, cost, and schedule are included as an appendix to the guide.

Systems Engineering Simulator (SES) Simulator Planning Guide

NASA Technical Reports Server (NTRS)

McFarlane, Michael

2011-01-01

The simulation process, milestones and inputs are unknowns to first-time users of the SES. The Simulator Planning Guide aids in establishing expectations for both NASA and non-NASA facility customers. The potential audience for this guide includes both internal and commercial spaceflight hardware/software developers. It is intended to assist their engineering personnel in simulation planning and execution. Material covered includes a roadmap of the simulation process, roles and responsibilities of facility and user, major milestones, facility capabilities, and inputs required by the facility. Samples of deliverables, facility interfaces, and inputs necessary to define scope, cost, and schedule are included as an appendix to the guide.

Computational Electromagnetics (CEM) Laboratory: Simulation Planning Guide

NASA Technical Reports Server (NTRS)

Khayat, Michael A.

2011-01-01

The simulation process, milestones and inputs are unknowns to first-time users of the CEM Laboratory. The Simulation Planning Guide aids in establishing expectations for both NASA and non-NASA facility customers. The potential audience for this guide includes both internal and commercial spaceflight hardware/software developers. It is intended to assist their engineering personnel in simulation planning and execution. Material covered includes a roadmap of the simulation process, roles and responsibilities of facility and user, major milestones, facility capabilities, and inputs required by the facility. Samples of deliverables, facility interfaces, and inputs necessary to define scope, cost, and schedule are included as an appendix to the guide.

40 CFR 408.172 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... CATEGORY Alaskan Mechanized Salmon Processing Subcategory § 408.172 Effluent limitations guidelines... available (BPT): (a) Any mechanized salmon processing facility located in population or processing centers... grease 29 11 pH (1) (1) 1 Within the range 6.0 to 9.0. (b) Any mechanized salmon processing facility not...

40 CFR 408.172 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2011 CFR

2011-07-01

... CATEGORY Alaskan Mechanized Salmon Processing Subcategory § 408.172 Effluent limitations guidelines... available (BPT): (a) Any mechanized salmon processing facility located in population or processing centers... grease 29 11 pH (1) (1) 1 Within the range 6.0 to 9.0. (b) Any mechanized salmon processing facility not...

76 FR 55572 - Approval and Promulgation of Implementation Plans; Georgia: Prevention of Significant...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-08

...) Exclude facilities that produce ethanol through a natural fermentation process from the definition of... 24060) which exclude facilities that produce ethanol through a natural fermentation process from the...

Hanford Spent Nuclear Fuel Project recommended path forward

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fulton, J.C.

The Spent Nuclear Fuel Project (the Project), in conjunction with the U.S. Department of Energy-commissioned Independent Technical Assessment (ITA) team, has developed engineered alternatives for expedited removal of spent nuclear fuel, including sludge, from the K Basins at Hanford. These alternatives, along with a foreign processing alternative offered by British Nuclear Fuels Limited (BNFL), were extensively reviewed and evaluated. Based on these evaluations, a Westinghouse Hanford Company (WHC) Recommended Path Forward for K Basins spent nuclear fuel has been developed and is presented in Volume I of this document. The recommendation constitutes an aggressive series of projects to construct andmore » operate systems and facilities to safely retrieve, package, transport, process, and store K Basins fuel and sludge. The overall processing and storage scheme is based on the ITA team`s proposed passivation and vault storage process. A dual purpose staging and vault storage facility provides an innovative feature which allows accelerated removal of fuel and sludge from the basins and minimizes programmatic risks beyond any of the originally proposed alternatives. The projects fit within a regulatory and National Environmental Policy Act (NEPA) overlay which mandates a two-phased approach to construction and operation of the needed facilities. The two-phase strategy packages and moves K Basins fuel and sludge to a newly constructed Staging and Storage Facility by the year 2000 where it is staged for processing. When an adjoining facility is constructed, the fuel is cycled through a stabilization process and returned to the Staging and Storage Facility for dry interim (40-year) storage. The estimated total expenditure for this Recommended Path Forward, including necessary new construction, operations, and deactivation of Project facilities through 2012, is approximately $1,150 million (unescalated).« less

Reduction of Environmental Listeria Using Gaseous Ozone in a Cheese Processing Facility.

PubMed

Eglezos, Sofroni; Dykes, Gary A

2018-05-01

A cheese processing facility seeking to reduce environmental Listeria colonization initiated a regime of ozonation across all production areas as an adjunct to its sanitation regimes. A total of 360 environmental samples from the facility were tested for Listeria over a 12-month period. A total of 15 areas before and 15 areas after ozonation were tested. Listeria isolations were significantly ( P < 0.001) reduced from 15.0% in the preozonation samples to 1.67% in the postozonation samples in all areas. No deleterious effects of ozonation were noted on the wall paneling, seals, synthetic floors, or cheese processing equipment. The ozonation regime was readily incorporated by sanitation staff into the existing good manufacturing practice program. The application of ozone may result in a significant reduction in the prevalence of Listeria in food processing facilities.

40 CFR 60.560 - Applicability and designation of affected facilities.

Code of Federal Regulations, 2012 CFR

2012-07-01

... section in a polypropylene or polyethylene production process is a potential affected facility for both... constructed, modified, or reconstructed and, in some instances, on the type of production process. (i) The... reconstructed after January 10, 1989, regardless of the type of production process being used, is January 10...

40 CFR 60.560 - Applicability and designation of affected facilities.

Code of Federal Regulations, 2011 CFR

2011-07-01

... section in a polypropylene or polyethylene production process is a potential affected facility for both... constructed, modified, or reconstructed and, in some instances, on the type of production process. (i) The... reconstructed after January 10, 1989, regardless of the type of production process being used, is January 10...

7 CFR 4284.924 - Ineligible uses of grant and matching funds.

Code of Federal Regulations, 2013 CFR

2013-01-01

... or facility (including a processing facility); (d) Purchase, lease purchase, or install fixed equipment, including processing equipment; (e) Purchase or repair vehicles, including boats; (f) Pay for the... processing and marketing of the value-added product; (h) Fund research and development; (i) Fund political or...

7 CFR 4284.924 - Ineligible uses of grant and matching funds.

Code of Federal Regulations, 2014 CFR

2014-01-01

... or facility (including a processing facility); (d) Purchase, lease purchase, or install fixed equipment, including processing equipment; (e) Purchase or repair vehicles, including boats; (f) Pay for the... processing and marketing of the value-added product; (h) Fund research and development; (i) Fund political or...

7 CFR 4284.924 - Ineligible uses of grant and matching funds.

Code of Federal Regulations, 2012 CFR

2012-01-01

... or facility (including a processing facility); (d) Purchase, lease purchase, or install fixed equipment, including processing equipment; (e) Purchase or repair vehicles, including boats; (f) Pay for the... processing and marketing of the value-added product; (h) Fund research and development; (i) Fund political or...

Guidelines for Automatic Data Processing Physical Security and Risk Management. Federal Information Processing Standards Publication 31.

ERIC Educational Resources Information Center

National Bureau of Standards (DOC), Washington, DC.

These guidelines provide a handbook for use by federal organizations in structuring physical security and risk management programs for their automatic data processing facilities. This publication discusses security analysis, natural disasters, supporting utilities, system reliability, procedural measures and controls, off-site facilities,…

DEVELOPMENT OF THE U.S. EPA'S METAL FINISHING FACILITY POLLUTION PREVENTION TOOL

EPA Science Inventory

Metal finishing processes are a type of chemical processes and can be modeled using Computer Aided Process Engineering (CAPE). Currently, the U.S. EPA is developing the Metal Finishing Facility Pollution Prevention Tool (MFFP2T), a pollution prevention software tool for the meta...

Prevalence of Clostridium difficile in uncooked ground meat products from Pittsburgh, Pennsylvania.

PubMed

Curry, Scott R; Marsh, Jane W; Schlackman, Jessica L; Harrison, Lee H

2012-06-01

The prevalence of Clostridium difficile in retail meat samples has varied widely. The food supply may be a source for C. difficile infections. A total of 102 ground meat and sausage samples from 3 grocers in Pittsburgh, PA, were cultured for C. difficile. Brand A pork sausages were resampled between May 2011 and January 2012. Two out of 102 (2.0%) meat products initially sampled were positive for C. difficile; both were pork sausage from brand A from the same processing facility (facility A). On subsequent sampling of brand A products, 10/19 samples from processing facility A and 1/10 samples from 3 other facilities were positive for C. difficile. The isolates recovered were inferred ribotype 078, comprising 6 genotypes. The prevalence of C. difficile in retail meat may not be as high as previously reported in North America. When contamination occurs, it may be related to events at processing facilities.

Canadian Innovations in Siting Hazardous Waste Management Facilities

PubMed

Kuhn; Ballard

1998-07-01

/ Siting hazardous waste facilities is an extremely complex and difficult endeavor. Public aversion to the construction of these facilities in or near their community often results in concerted opposition, referred to as the NIMBY syndrome. For the most part, siting processes do not fail because of inadequate environmental or technical considerations, but because of the adversarial decision-making strategies employed by the proponents. Innovative siting processes used in the provinces of Alberta and Manitoba offer tangible evidence of the successful application of an innovative siting approach based on the principles of decentralization of decision-making authority and full and meaningful public involvement. The purpose of this paper is to evaluate four Canadian siting processes from the perspective of public participation and access to decision-making authority. Examples of siting processes related to hazardous waste management facilities are provided from the provinces of Alberta, Manitoba, British Columbia, and Ontario. Siting has evolved from approaches dominated by top-down decision making to increasing decentralized and pluralistic approaches. Focusing on social and political concerns of potentially affected communities and on the process of decision making itself are fundamental to achieving siting success. In Alberta initially, and later in Manitoba, this new "open approach" to siting has resulted in the construction of the first two comprehensive hazardous waste treatment facilities in Canada.KEY WORDS: Hazardous waste facilities; Siting methodologies; Public participation

Simulation of mass storage systems operating in a large data processing facility

NASA Technical Reports Server (NTRS)

Holmes, R.

1972-01-01

A mass storage simulation program was written to aid system designers in the design of a data processing facility. It acts as a tool for measuring the overall effect on the facility of on-line mass storage systems, and it provides the means of measuring and comparing the performance of competing mass storage systems. The performance of the simulation program is demonstrated.

40 CFR 419.40 - Applicability; description of the lube subcategory.

Code of Federal Regulations, 2011 CFR

2011-07-01

... discharges from any facility that produces petroleum products by the use of topping, cracking, and lube oil manufacturing processes, whether or not the facility includes any process in addition to topping, cracking, and...

40 CFR 419.40 - Applicability; description of the lube subcategory.

Code of Federal Regulations, 2010 CFR

2010-07-01

... discharges from any facility that produces petroleum products by the use of topping, cracking, and lube oil manufacturing processes, whether or not the facility includes any process in addition to topping, cracking, and...

40 CFR 60.140 - Applicability and designation of affected facility.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Performance for Primary Emissions from Basic Oxygen Process Furnaces for Which Construction is Commenced After... which the provisions of this subpart apply is each basic oxygen process furnace. (b) Any facility under...

40 CFR 60.140 - Applicability and designation of affected facility.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Performance for Primary Emissions from Basic Oxygen Process Furnaces for Which Construction is Commenced After... which the provisions of this subpart apply is each basic oxygen process furnace. (b) Any facility under...

40 CFR 60.140 - Applicability and designation of affected facility.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Performance for Primary Emissions from Basic Oxygen Process Furnaces for Which Construction is Commenced After... which the provisions of this subpart apply is each basic oxygen process furnace. (b) Any facility under...

40 CFR 60.140 - Applicability and designation of affected facility.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Performance for Primary Emissions from Basic Oxygen Process Furnaces for Which Construction is Commenced After... which the provisions of this subpart apply is each basic oxygen process furnace. (b) Any facility under...

40 CFR 60.140 - Applicability and designation of affected facility.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Performance for Primary Emissions from Basic Oxygen Process Furnaces for Which Construction is Commenced After... which the provisions of this subpart apply is each basic oxygen process furnace. (b) Any facility under...

Planning and Designing Facilities. Facility Design and Development--Part 1

ERIC Educational Resources Information Center

Hypes, Michael G.

2006-01-01

Before one begins the planning process for a new facility, it is important to determine if there is a need for a new facility. The demand for a new facility can be drawn from increases in the number of users, the type of users, and the type of events to be conducted in the facility. A feasibility study should be conducted to analyze the legal…

Standard services for the capture, processing, and distribution of packetized telemetry data

NASA Technical Reports Server (NTRS)

Stallings, William H.

1989-01-01

Standard functional services for the capture, processing, and distribution of packetized data are discussed with particular reference to the future implementation of packet processing systems, such as those for the Space Station Freedom. The major functions are listed under the following major categories: input processing, packet processing, and output processing. A functional block diagram of a packet data processing facility is presented, showing the distribution of the various processing functions as well as the primary data flow through the facility.

Web-Based Requesting and Scheduling Use of Facilities

NASA Technical Reports Server (NTRS)

Yeager, Carolyn M.

2010-01-01

Automated User's Training Operations Facility Utilization Request (AutoFUR) is prototype software that administers a Web-based system for requesting and allocating facilities and equipment for astronaut-training classes in conjunction with scheduling the classes. AutoFUR also has potential for similar use in such applications as scheduling flight-simulation equipment and instructors in commercial airplane-pilot training, managing preventive- maintenance facilities, and scheduling operating rooms, doctors, nurses, and medical equipment for surgery. Whereas requesting and allocation of facilities was previously a manual process that entailed examination of documents (including paper drawings) from different sources, AutoFUR partly automates the process and makes all of the relevant information available via the requester s computer. By use of AutoFUR, an instructor can fill out a facility-utilization request (FUR) form on line, consult the applicable flight manifest(s) to determine what equipment is needed and where it should be placed in the training facility, reserve the corresponding hardware listed in a training-hardware inventory database, search for alternative hardware if necessary, submit the FUR for processing, and cause paper forms to be printed. Auto-FUR also maintains a searchable archive of prior FURs.

Conceptual design assessment for the co-firing of bio-refinery supplied lignin project. Quarterly report, July 1--September 30, 2000

DOE Office of Scientific and Technical Information (OSTI.GOV)

Berglund, T.; Ranney, J.T.; Babb, C.L.

2000-10-01

The initial design criteria of the MSW to ethanol facility have been completed along with preliminary site identification and layouts for the processing facility. These items are the first step in evaluating the feasibility of this co-located facility. Pilot facility design and modification are underway for the production and dewatering of the lignin fuel. Major process equipment identification has been completed and several key unit operations will be accomplished on rental equipment. Equipment not available for rental or at TVA has been ordered and facility modification and shakedown will begin in October. The study of the interface and resulting impactsmore » on the TVA Colbert facility are underway. The TVA Colbert fossil plant is fully capable of providing a reliable steam supply for the proposed Masada waste processing facility. The preferred supply location in the Colbert steam cycle has been identified as have possible steam pipeline routes to the Colbert boundary. Additional analysis is underway to fully predict the impact of the steam supply on Colbert plant performance and to select a final steam pipeline route.« less

ARM Mentor Selection Process

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sisterson, D. L.

2015-10-01

The Atmospheric Radiation Measurement (ARM) Program was created in 1989 with funding from the U.S. Department of Energy (DOE) to develop several highly instrumented ground stations to study cloud formation processes and their influence on radiative transfer. In 2003, the ARM Program became a national scientific user facility, known as the ARM Climate Research Facility. This scientific infrastructure provides for fixed sites, mobile facilities, an aerial facility, and a data archive available for use by scientists worldwide through the ARM Climate Research Facility—a scientific user facility. The ARM Climate Research Facility currently operates more than 300 instrument systems that providemore » ground-based observations of the atmospheric column. To keep ARM at the forefront of climate observations, the ARM infrastructure depends heavily on instrument scientists and engineers, also known as lead mentors. Lead mentors must have an excellent understanding of in situ and remote-sensing instrumentation theory and operation and have comprehensive knowledge of critical scale-dependent atmospheric processes. They must also possess the technical and analytical skills to develop new data retrievals that provide innovative approaches for creating research-quality data sets. The ARM Climate Research Facility is seeking the best overall qualified candidate who can fulfill lead mentor requirements in a timely manner.« less

Contamination control and cleanliness level integrity for the Space Shuttle Orbiter PLB, payloads and facilities at KSC

NASA Technical Reports Server (NTRS)

Bartelson, D.

1984-01-01

The PLB, its cargo, and payload canister must satisfy the cleanliness requirements of visual clean (VC) level 1, 2, 3, or special as stated in NASA document SN-C-0005A. The specific level of cleanliness is chosen by the payload bay customer for their mission. During orbiter turnaround processing at KSC, the payload bay is exposed to the environments of the Orbiter Processing Facility (OPF) and the Payload Changeout Room (PCR). In supportive response to the orbiter payload bay/facility interface, it is necessary that the facility environment be controlled and monitored to protect the cleanliness/environmental integrity of the payload bay and its cargo. Techniques used to meet environmental requirements during orbiter processing are introduced.

KSC-2014-4133

NASA Image and Video Library

2014-09-25

CAPE CANAVERAL, Fla. – Operations are underway to couple Florida East Coast Railway, or FEC, locomotives No. 433 and No. 428 on the track alongside the Indian River, north of Launch Complex 39 at NASA’s Kennedy Space Center in Florida. Kennedy's Center Planning and Development Directorate has enlisted the locomotives to support a Rail Vibration Test for the Canaveral Port Authority. The purpose of the test is to collect amplitude, frequency and vibration test data utilizing two Florida East Coast locomotives operating on KSC tracks to ensure that future railroad operations will not affect launch vehicle processing at the center. Buildings instrumented for the test include the Rotation Processing Surge Facility, Thermal Protection Systems Facility, Vehicle Assembly Building, Orbiter Processing Facility and Booster Fabrication Facility. Photo credit: NASA/Daniel Casper

A Guide for Developing Standard Operating Job Procedures for the Screening & Grinding Process Wastewater Treatment Facility. SOJP No. 1.

ERIC Educational Resources Information Center

Deal, Gerald A.; Montgomery, James A.

This guide describes standard operating job procedures for the screening and grinding process of wastewater treatment facilities. The objective of this process is the removal of coarse materials from the raw waste stream for the protection of subsequent equipment and processes. The guide gives step-by-step instructions for safety inspection,…

A Guide for Developing Standard Operating Job Procedures for the Sludge Thickening Process Wastewater Treatment Facility. SOJP No. 9.

ERIC Educational Resources Information Center

Schwing, Carl M.

This guide describes standard operating job procedures for the screening and grinding process of wastewater treatment facilities. The objective of this process is the removal of coarse materials from the raw waste stream for the protection of subsequent equipment and processes. The guide gives step-by-step instructions for safety inspection,…

Vibration and Acoustic Test Facility (VATF): User Test Planning Guide

NASA Technical Reports Server (NTRS)

Fantasia, Peter M.

2011-01-01

Test process, milestones and inputs are unknowns to first-time users of the VATF. The User Test Planning Guide aids in establishing expectations for both NASA and non-NASA facility customers. The potential audience for this guide includes both internal and commercial spaceflight hardware/software developers. It is intended to assist their test engineering personnel in test planning and execution. Material covered includes a roadmap of the test process, roles and responsibilities of facility and user, major milestones, facility capabilities, and inputs required by the facility. Samples of deliverables, test article interfaces, and inputs necessary to define test scope, cost, and schedule are included as an appendix to the guide.

Atmospheric Reentry Materials and Structures Evaluation Facility (ARMSEF). User Test Planning Guide

NASA Technical Reports Server (NTRS)

2011-01-01

Test process, milestones and inputs are unknowns to first-time users of the ARMSEF. The User Test Planning Guide aids in establishing expectations for both NASA and non-NASA facility customers. The potential audience for this guide includes both internal and commercial spaceflight hardware/software developers. It is intended to assist their test engineering personnel in test planning and execution. Material covered includes a roadmap of the test process, roles and responsibilities of facility and user, major milestones, facility capabilities, and inputs required by the facility. Samples of deliverables, test article interfaces, and inputs necessary to define test scope, cost, and schedule are included as an appendix to the guide.

Department of Energy Technology Readiness Assessments - Process Guide and Training Plan

DTIC Science & Technology

2008-09-12

Hanford Waste Treatment and Immobilization Plant ( WTP ) Analytical Laboratory, Low Activity Waste (LAW) Facility and Balance of Facilities (3 TRAs... WTP High-Level Waste (HLW) Facility – WTP Pre-Treatment (PT) Facility – Hanford River Protection Project Low Activity Waste Treatment Alternatives

State Requirements for Educational Facilities, 1997.

ERIC Educational Resources Information Center

Florida State Dept. of Education, Tallahassee. Office of Educational Facilities.

This document updates Florida's deregulation of construction of educational facilities guidelines, while keeping as the primary focus the safety of the students in pre-K through community college facilities. Organized by the sequence of steps required in the facilities procurement process, it covers general definitions, property…

New Trends in Facility Asset Management.

ERIC Educational Resources Information Center

Adams, Matt

2000-01-01

Explains new, positive trends in facility asset management that encompasses greater acceptance and involvement of facility managers in the financial planning process, greater awareness of the need for maintenance, and facility administrators taking a greater role with business officers. The new climate for alternative renewal financing proposals…

Inspired Planning

ERIC Educational Resources Information Center

Erickson, Paul W.

2009-01-01

Long-range facility planning is a comprehensive process for preparing education institutions for the future and confirm that facilities meet current needs. A long-range facilities plan (LRFP) evaluates how facilities support programs and the educational needs of students, staff and the community. Each school district or college has unique needs…

The Influence of Process Equipment on the Properties of Suspension Plasma Sprayed Yttria-Stabilized Zirconia Coatings

NASA Astrophysics Data System (ADS)

Marr, Michael; Waldbillig, David; Kesler, Olivera

2013-03-01

Suspension plasma-sprayed YSZ coatings were deposited at lab-scale and production-type facilities to investigate the effect of process equipment on coating properties. The target application for these coatings is solid oxide fuel cell (SOFC) electrolytes; hence, dense microstructures with low permeability values were preferred. Both facilities had the same torch but different suspension feeding systems, torch robots, and substrate holders. The lab-scale facility had higher torch-substrate relative speeds compared with the production-type facility. On porous stainless steel substrates, permeabilities and microstructures were comparable for coatings from both facilities, and no segmentation cracks were observed. Coating permeability was further reduced by increasing substrate temperatures during deposition or reducing suspension feed rates. On SOFC cathode substrates, coatings made in the production-type facility had higher permeabilities and more segmentation cracks compared with coatings made in the lab-scale facility. Increased cracking in coatings from the production-type facility was likely caused mainly by its lower torch-substrate relative speed.

Floating the Ball: Advances in the Technology of Electrostatic Levitation

NASA Technical Reports Server (NTRS)

Rogers, Jan R.

2006-01-01

Electrostatic Levitation (ESL) is an emerging technology. The MSFC ESL is a NASA facility that supports investigations of refractory solids and melts. The facility can be used to process a wide variety of materials including metals, alloys, ceramics, glasses and semiconductors. Containerless processing via ESL provides a high-purity environment for the study of high temperature materials and access to metastable states. Scientific topics investigated in the facility include nucleation, undercooling, metastable state formation and metallic glass formation. Additionally, the MSFC ESL provides data for the determination of phase diagrams, time-temperature-transition diagrams, viscosity, surface tension, density, heat capacity and creep resistance. In order to support a diverse research community, the MSFC ESL facility has developed a number of technical capabilities, including a portable system for in situ studies of structural tran$hrmations during processing at the high-energy X-ray beamline at the Advanced Photon Source of Argonne National Laboratory. The capabilities of the MSFC ESL facilities will be discussed and selected results of materials processing and characterization studies will be presented.

Implementing iRound: A Computer-Based Auditing Tool.

PubMed

Brady, Darcie

Many hospitals use rounding or auditing as a tool to help identify gaps and needs in quality and process performance. Some hospitals are also using rounding to help improve patient experience. It is known that purposeful rounding helps improve Hospital Consumer Assessment of Healthcare Providers and Systems scores by helping manage patient expectations, provide service recovery, and recognize quality caregivers. Rounding works when a standard method is used across the facility, where data are comparable and trustworthy. This facility had a pen-and-paper process in place that made data reporting difficult, created a silo culture between departments, and most audits and rounds were completed differently on each unit. It was recognized that this facility needed to standardize the rounding and auditing process. The tool created by the Advisory Board called iRound was chosen as the tool this facility would use for patient experience rounds as well as process and quality rounding. The success of the iRound tool in this facility depended on several factors that started many months before implementation to current everyday usage.

Spacelab Data Processing Facility

NASA Technical Reports Server (NTRS)

1983-01-01

The Spacelab Data Processing Facility (SDPF) processes, monitors, and accounts for the payload data from Spacelab and other Shuttle missions and forwards relevant data to various user facilities worldwide. The SLDPF is divided into the Spacelab Input Processing System (SIPS) and the Spacelab Output Processing System (SOPS). The SIPS division demultiplexes, synchronizes, time tags, quality checks, accounts for the data, and formats the data onto tapes. The SOPS division further edits, blocks, formats, and records the data on tape for shipment to users. User experiments must conform to the Spacelab's onboard High Rate Multiplexer (HRM) format for maximum process ability. Audio, analog, instrumentation, high density, experiment data, input/output data, quality control and accounting, and experimental channel tapes along with a variety of spacelab ancillary tapes are provided to the user by SLDPF.

Fifth anniversary of the first element of the International Spac

NASA Image and Video Library

2003-12-03

In the Space Station Processing Facility, (from left) David Bethay, Boeing/ISS Florida Operations; Charlie Precourt, deputy manager of the International Space Station Program; and Tip Talone, director of Space Station and Payload Processing, give an overview of Space Station processing for the media. Members of the media were invited to commemorate the fifth anniversary of the launch of the first element of the International Space Station by touring the Space Station Processing Facility (SSPF) at KSC. Reporters also had the opportunity to see Space Station hardware that is being processed for deployment once the Space Shuttles return to flight. The facility tour also included an opportunity for reporters to talk with NASA and Boeing mission managers about the various hardware elements currently being processed for flight.

Predictive Analytics to Support Real-Time Management in Pathology Facilities.

PubMed

Lessard, Lysanne; Michalowski, Wojtek; Chen Li, Wei; Amyot, Daniel; Halwani, Fawaz; Banerjee, Diponkar

2016-01-01

Predictive analytics can provide valuable support to the effective management of pathology facilities. The introduction of new tests and technologies in anatomical pathology will increase the volume of specimens to be processed, as well as the complexity of pathology processes. In order for predictive analytics to address managerial challenges associated with the volume and complexity increases, it is important to pinpoint the areas where pathology managers would most benefit from predictive capabilities. We illustrate common issues in managing pathology facilities with an analysis of the surgical specimen process at the Department of Pathology and Laboratory Medicine (DPLM) at The Ottawa Hospital, which processes all surgical specimens for the Eastern Ontario Regional Laboratory Association. We then show how predictive analytics could be used to support management. Our proposed approach can be generalized beyond the DPLM, contributing to a more effective management of pathology facilities and in turn to quicker clinical diagnoses.

Predictive Analytics to Support Real-Time Management in Pathology Facilities

PubMed Central

Lessard, Lysanne; Michalowski, Wojtek; Chen Li, Wei; Amyot, Daniel; Halwani, Fawaz; Banerjee, Diponkar

2016-01-01

Predictive analytics can provide valuable support to the effective management of pathology facilities. The introduction of new tests and technologies in anatomical pathology will increase the volume of specimens to be processed, as well as the complexity of pathology processes. In order for predictive analytics to address managerial challenges associated with the volume and complexity increases, it is important to pinpoint the areas where pathology managers would most benefit from predictive capabilities. We illustrate common issues in managing pathology facilities with an analysis of the surgical specimen process at the Department of Pathology and Laboratory Medicine (DPLM) at The Ottawa Hospital, which processes all surgical specimens for the Eastern Ontario Regional Laboratory Association. We then show how predictive analytics could be used to support management. Our proposed approach can be generalized beyond the DPLM, contributing to a more effective management of pathology facilities and in turn to quicker clinical diagnoses. PMID:28269873

GEOTAIL Spacecraft historical data report

NASA Technical Reports Server (NTRS)

Boersig, George R.; Kruse, Lawrence F.

1993-01-01

The purpose of this GEOTAIL Historical Report is to document ground processing operations information gathered on the GEOTAIL mission during processing activities at the Cape Canaveral Air Force Station (CCAFS). It is hoped that this report may aid management analysis, improve integration processing and forecasting of processing trends, and reduce real-time schedule changes. The GEOTAIL payload is the third Delta 2 Expendable Launch Vehicle (ELV) mission to document historical data. Comparisons of planned versus as-run schedule information are displayed. Information will generally fall into the following categories: (1) payload stay times (payload processing facility/hazardous processing facility/launch complex-17A); (2) payload processing times (planned, actual); (3) schedule delays; (4) integrated test times (experiments/launch vehicle); (5) unique customer support requirements; (6) modifications performed at facilities; (7) other appropriate information (Appendices A & B); and (8) lessons learned (reference Appendix C).

KENNEDY SPACE CENTER, FLA. - Employees check out the new chamber facilities of the Space Life Sciences Lab (SLSL), formerly known as the Space Experiment Research and Processing Laboratory (SERPL). From left are Ray Wheeler, with NASA; Debbie Wells and Larry Burns, with Dynamac; A.O. Rule, president of Environmental Growth Chambers, Inc. (ECG); Neil Yorio, with Dynamac; and John Wiezchowski, with ECG. The SLSL is a state-of-the-art facility being built for ISS biotechnology research. Developed as a partnership between NASA-KSC and the State of Florida, NASA’s life sciences contractor will be the primary tenant of the facility, leasing space to conduct flight experiment processing and NASA-sponsored research. About 20 percent of the facility will be available for use by Florida’s university researchers through the Florida Space Research Institute.

NASA Image and Video Library

2003-09-10

KENNEDY SPACE CENTER, FLA. - Employees check out the new chamber facilities of the Space Life Sciences Lab (SLSL), formerly known as the Space Experiment Research and Processing Laboratory (SERPL). From left are Ray Wheeler, with NASA; Debbie Wells and Larry Burns, with Dynamac; A.O. Rule, president of Environmental Growth Chambers, Inc. (ECG); Neil Yorio, with Dynamac; and John Wiezchowski, with ECG. The SLSL is a state-of-the-art facility being built for ISS biotechnology research. Developed as a partnership between NASA-KSC and the State of Florida, NASA’s life sciences contractor will be the primary tenant of the facility, leasing space to conduct flight experiment processing and NASA-sponsored research. About 20 percent of the facility will be available for use by Florida’s university researchers through the Florida Space Research Institute.

AERIAL SHOWING COMPLETED REMOTE ANALYTICAL FACILITY (CPP627) ADJOINING FUEL PROCESSING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

AERIAL SHOWING COMPLETED REMOTE ANALYTICAL FACILITY (CPP-627) ADJOINING FUEL PROCESSING BUILDING AND EXCAVATION FOR HOT PILOT PLANT TO RIGHT (CPP-640). INL PHOTO NUMBER NRTS-60-1221. J. Anderson, Photographer, 3/22/1960 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

Laser materials processing facility

NASA Technical Reports Server (NTRS)

Haggerty, J. S.

1982-01-01

The laser materials processing facility and its capabilities are described. A CO2 laser with continuous wave, repetitive pulse, and shaped power-time cycles is employed. The laser heated crystal growth station was used to produce metal and metal oxide single crystals and for cutting and shaping experiments using Si3N4 to displace diamond shaping processes.

Determining If Phylogenetic Relatedness of Listeria Monocytogenes Isolates Corresponds to Persistence in Poultry Processing Plants Using Whole-Genome Sequencing

USDA-ARS?s Scientific Manuscript database

Introduction: Controlling Listeria monocytogenes on ready-to-eat meat and poultry products and in food processing facilities is challenging. Surveys have found that some L. monocytogenes types are more persistent in processing facilities than others, but the reason is unknown. It is possible persist...

26 CFR 1.142(a)(6)-1 - Exempt facility bonds: solid waste disposal facilities.

Code of Federal Regulations, 2014 CFR

2014-04-01

... section), or a recycling process (as defined in paragraph (d)(3) of this section). Absent an express... product within the meaning of paragraph (e) of this section. (3) Recycling process—(i) In general. The term recycling process means reconstituting, transforming, or otherwise processing solid waste into a...

76 FR 60941 - Policy Regarding Submittal of Amendments for Processing of Equivalent Feed at Licensed Uranium...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-30

... State-licensed uranium recovery site, either conventional, heap leach, or in situ recovery. DATES... types of new uranium recovery facilities (conventional mills, heap leach facilities, and in situ... from the ground for processing at a mill. Rather, the ore is processed in-situ with the resulting...

Onboard experiment data support facility, task 1 report. [space shuttles

NASA Technical Reports Server (NTRS)

1975-01-01

The conceptual design and specifications are developed for an onboard experiment data support facility (OEDSF) to provide end to end processing of data from various payloads on board space shuttles. Classical data processing requirements are defined and modeled. Onboard processing requirements are analyzed. Specifications are included for an onboard processor.

The quality of family planning services and client satisfaction in the public and private sectors in Kenya.

PubMed

Agha, Sohail; Do, Mai

2009-04-01

To compare the quality of family planning services delivered at public and private facilities in Kenya. Data from the 2004 Kenya Service Provision Assessment were analysed. The Kenya Service Provision Assessment is a representative sample of health facilities in the public and private sectors, and comprises data obtained from a facility inventory, service provider interviews, observations of client-provider interactions and exit interviews. Quality-of-care indicators are compared between the public and private sectors along three dimensions: structure, process and outcome. Private facilities were superior to public sector facilities in terms of physical infrastructure and the availability of services. Public sector facilities were more likely to have management systems in place. There was no difference between public and private providers in the technical quality of care provided. Private providers were better at managing interpersonal aspects of care. The higher level of client satisfaction at private facilities could not be explained by differences between public and private facilities in structural and process aspects of care. Formal private sector facilities providing family planning services exhibit greater readiness to provide services and greater attention to client needs than public sector facilities in Kenya. Consistent with this, client satisfaction is much higher at private facilities. Technical quality of care provided is similar in public and private facilities.

Aeropropulsion facilities configuration control: Procedures manual

NASA Technical Reports Server (NTRS)

Lavelle, James J.

1990-01-01

Lewis Research Center senior management directed that the aeropropulsion facilities be put under configuration control. A Configuration Management (CM) program was established by the Facilities Management Branch of the Aeropropulsion Facilities and Experiments Division. Under the CM program, a support service contractor was engaged to staff and implement the program. The Aeronautics Directorate has over 30 facilities at Lewis of various sizes and complexities. Under the program, a Facility Baseline List (FBL) was established for each facility, listing which systems and their documents were to be placed under configuration control. A Change Control System (CCS) was established requiring that any proposed changes to FBL systems or their documents were to be processed as per the CCS. Limited access control of the FBL master drawings was implemented and an audit system established to ensure all facility changes are properly processed. This procedures manual sets forth the policy and responsibilities to ensure all key documents constituting a facilities configuration are kept current, modified as needed, and verified to reflect any proposed change. This is the essence of the CM program.

[Hygiene provisions for the processing of food in nurseries and child care facilities. Approaching problems in practical experience].

PubMed

Bosche, H; Schmeisser, N

2008-11-01

In Germany more than 2 million children under the age of six attend child care institutions. Among the duties, these institutions have to provide meals to the children. Several food-borne viruses pose a particular threat to infants. In accordance with the new European Law on Food Hygiene nurseries and child care facilities are business premises as they process and dispense food. Law requires guarding all stages of food acquisition, storage, preparation and dispersal against health hazards. Furthermore, facilities are legally required to provide risk control and to ensure that food issued by their kitchen does not pose a health hazard upon consumption. Overall, child care facilities are given by far a more comprehensive responsibility under the new European Law. This article introduces a hygiene manual for child care facilities in accordance with the EU Law on Hygiene, which was field tested in more than 70 child care facilities during the course of the extensive organisational process. The manual supplies easy-tohandle instructions and form sheets for documentation and hence assists in realising legal provisions.

7 CFR 1794.21 - Categorically excluded proposals without an ER.

Code of Federal Regulations, 2010 CFR

2010-01-01

... an emergency situation to return to service damaged facilities of an applicant's system. (b) Electric... electric generating or fuel processing facilities and related support structures where there is negligible... boundaries of an existing electric generating facility site. A description of the facilities to be...

FACILITY LAYOUT OF FUEL STORAGE BUILDING (CPP603) SHOWING STORAGE BASINS, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

FACILITY LAYOUT OF FUEL STORAGE BUILDING (CPP-603) SHOWING STORAGE BASINS, FUEL ELEMENT CUTTING FACILITY, AND DRY GRAPHITE STORAGE FACILITY. INL DRAWING NUMBER 200-0603-00-030-056329. - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

Process cost and facility considerations in the selection of primary cell culture clarification technology.

PubMed

Felo, Michael; Christensen, Brandon; Higgins, John

2013-01-01

The bioreactor volume delineating the selection of primary clarification technology is not always easily defined. Development of a commercial scale process for the manufacture of therapeutic proteins requires scale-up from a few liters to thousands of liters. While the separation techniques used for protein purification are largely conserved across scales, the separation techniques for primary cell culture clarification vary with scale. Process models were developed to compare monoclonal antibody production costs using two cell culture clarification technologies. One process model was created for cell culture clarification by disc stack centrifugation with depth filtration. A second process model was created for clarification by multi-stage depth filtration. Analyses were performed to examine the influence of bioreactor volume, product titer, depth filter capacity, and facility utilization on overall operating costs. At bioreactor volumes <1,000 L, clarification using multi-stage depth filtration offers cost savings compared to clarification using centrifugation. For bioreactor volumes >5,000 L, clarification using centrifugation followed by depth filtration offers significant cost savings. For bioreactor volumes of ∼ 2,000 L, clarification costs are similar between depth filtration and centrifugation. At this scale, factors including facility utilization, available capital, ease of process development, implementation timelines, and process performance characterization play an important role in clarification technology selection. In the case study presented, a multi-product facility selected multi-stage depth filtration for cell culture clarification at the 500 and 2,000 L scales of operation. Facility implementation timelines, process development activities, equipment commissioning and validation, scale-up effects, and process robustness are examined. © 2013 American Institute of Chemical Engineers.

Design Process Overview

DOE Office of Scientific and Technical Information (OSTI.GOV)

Halkjaer-Knudsen, Vibeke

2014-11-01

For the purposes of this paper, a Biocontainment facility is a laboratory, production facility, or similar building that handles contagious biological materials in a safe and responsible manner. This specialized facility, also called a containment facility or a high containment facility reduces the potential for biological agents to be released into the environment, provides a safe work environment for the employees, and supports good laboratory practices.

Space station automation study: Automation requriements derived from space manufacturing concepts,volume 2

NASA Technical Reports Server (NTRS)

1984-01-01

Automation reuirements were developed for two manufacturing concepts: (1) Gallium Arsenide Electroepitaxial Crystal Production and Wafer Manufacturing Facility, and (2) Gallium Arsenide VLSI Microelectronics Chip Processing Facility. A functional overview of the ultimate design concept incoporating the two manufacturing facilities on the space station are provided. The concepts were selected to facilitate an in-depth analysis of manufacturing automation requirements in the form of process mechanization, teleoperation and robotics, sensors, and artificial intelligence. While the cost-effectiveness of these facilities was not analyzed, both appear entirely feasible for the year 2000 timeframe.

KSC-2011-7851

NASA Image and Video Library

2011-11-21

CAPE CANAVERAL, Fla. – Members of the media tour several facilities, including the Multi-Payload Processing Facility, during the 21st Century Ground Systems Program Tour at Kennedy Space Center in Florida. Other tour stops were the Launch Equipment Test Facility, the Operations & Checkout Building and the Canister Rotation Facility. NASA’s 21st Century Ground Systems Program was initiated at Kennedy Space Center to establish the needed launch and processing infrastructure to support the Space Launch System Program and to work toward transforming the landscape of the launch site for a multi-faceted user community. Photo credit: NASA/Jim Grossmann

KSC-2011-7846

NASA Image and Video Library

2011-11-21

CAPE CANAVERAL, Fla. – Members of the media tour several facilities, including the Launch Equipment Test Facility in the Industrial Area, during the 21st Century Ground Systems Program Tour at Kennedy Space Center in Florida. Other tour stops were the Operations & Checkout Building, the Multi-Payload Processing Facility and the Canister Rotation Facility. NASA’s 21st Century Ground Systems Program was initiated at Kennedy Space Center to establish the needed launch and processing infrastructure to support the Space Launch System Program and to work toward transforming the landscape of the launch site for a multi-faceted user community. Photo credit: NASA/Jim Grossmann

KSC-2011-7847

NASA Image and Video Library

2011-11-21

CAPE CANAVERAL, Fla. – Members of the media tour several facilities, including the Launch Equipment Test Facility in the Industrial Area, during the 21st Century Ground Systems Program Tour at Kennedy Space Center in Florida. Other tour stops were the Operations & Checkout Building, the Multi-Payload Processing Facility and the Canister Rotation Facility. NASA’s 21st Century Ground Systems Program was initiated at Kennedy Space Center to establish the needed launch and processing infrastructure to support the Space Launch System Program and to work toward transforming the landscape of the launch site for a multi-faceted user community. Photo credit: NASA/Jim Grossmann

KSC-2011-1342

NASA Image and Video Library

2011-02-02

CAPE CANAVERAL, Fla. -- At NASA's Kennedy Space Center in Florida, KSC firefighters were on the scene after a backhoe inadvertently struck a natural gas line at around 8:40 a.m. EST in the area north of the Multi Function Facility (MFF). As a precaution, personnel were evacuated from Orbiter Processing Facilities 1 and 2, the MFF, Processing Control Center and Operations Support Building (OSB) I. All traffic was blocked on the Saturn Causeway near the facilities. There were no injuries or damage to any facilities and personnel were allowed back into their buildings before mid-day and the roadway open to traffic. Photo credit: NASA/Jack Pfaller

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, Executive Director of NASDA Koji Yamamoto (center) gets information about the facility while on a tour of KSC. Behind the group is the Japanese Experiment Module (JEM)/pressurized module. Mr. Yamamoto is at KSC for a welcome ceremony involving the arrival of JEM.

NASA Image and Video Library

2003-06-12

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, Executive Director of NASDA Koji Yamamoto (center) gets information about the facility while on a tour of KSC. Behind the group is the Japanese Experiment Module (JEM)/pressurized module. Mr. Yamamoto is at KSC for a welcome ceremony involving the arrival of JEM.

An integrated lean-methods approach to hospital facilities redesign.

PubMed

Nicholas, John

2012-01-01

Lean production methods for eliminating waste and improving processes in manufacturing are now being applied in healthcare. As the author shows, the methods are appropriate for redesigning hospital facilities. When used in an integrated manner and employing teams of mostly clinicians, the methods produce facility designs that are custom-fit to patient needs and caregiver work processes, and reduce operational costs. The author reviews lean methods and an approach for integrating them in the redesign of hospital facilities. A case example of the redesign of an emergency department shows the feasibility and benefits of the approach.

Using multi-disciplinary strategic master facilities planning for organizations experiencing programmatic re-direction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heubach, J.G.; Weimer, W.C.; Bruce, W.A.

Facility master planning is critical to the future productivity of a laboratory and the quality of worklife for the laboratory staff. For organizations undergoing programmatic re-direction, a master facility planning approach linked to the organization`s strategic planning process is even more important. Major changes in an organization such as programmatic re-direction can significantly impact a broad range of variables which exceed the expertise of traditional planning teams, e.g., capacity variability, work team organization, organizational culture, and work process simplification. By expanding the diversity of the participants of the planning team, there is a greater likelihood that a research organization`s scientific,more » organizational, economic, and employees` needs can be meshed in the strategic plan and facility plan. Recent recommendations from facility planners suggest drawing from diverse fields in building multi-disciplinary planning teams: Architecture, engineering, natural science, social psychology, and strategic planning (Gibson,1993). For organizations undergoing significant operational or culture change, the master facility planning team should also include members with expertise in organizational effectiveness, industrial engineering, human resources, and environmental psychology. A recent planning and design project provides an example which illustrates the use of an expanded multi-disciplinary team engaged in planning laboratory renovations for a research organization undergoing programmatic re-direction. The purpose of the proposed poster session is to present a multi-disciplinary master facility planning process linked to an organization`s strategic planning process or organizational strategies.« less

9 CFR 590.520 - Breaking room facilities.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Breaking room facilities. 590.520..., Processing, and Facility Requirements § 590.520 Breaking room facilities. (a) The breaking room shall have at.... (d) Ventilation shall provide for: (1) A positive flow of outside filtered air through the room; (2...

9 CFR 590.520 - Breaking room facilities.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Breaking room facilities. 590.520..., Processing, and Facility Requirements § 590.520 Breaking room facilities. (a) The breaking room shall have at.... (d) Ventilation shall provide for: (1) A positive flow of outside filtered air through the room; (2...

9 CFR 590.520 - Breaking room facilities.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Breaking room facilities. 590.520..., Processing, and Facility Requirements § 590.520 Breaking room facilities. (a) The breaking room shall have at.... (d) Ventilation shall provide for: (1) A positive flow of outside filtered air through the room; (2...

Capabilities and constraints of NASA's ground-based reduced gravity facilities

NASA Technical Reports Server (NTRS)

Lekan, Jack; Neumann, Eric S.; Sotos, Raymond G.

1993-01-01

The ground-based reduced gravity facilities of NASA have been utilized to support numerous investigations addressing various processes and phenomina in several disciplines for the past 30 years. These facilities, which include drop towers, drop tubes, aircraft, and sounding rockets are able to provide a low gravity environment (gravitational levels that range from 10(exp -2)g to 10(exp -6)g) by creating a free fall or semi-free fall condition where the force of gravity on an experiment is offset by its linear acceleration during the 'fall' (drop or parabola). The low gravity condition obtained on the ground is the same as that of an orbiting spacecraft which is in a state of perpetual free fall. The gravitational levels and associated duration times associated with the full spectrum of reduced gravity facilities including spaced-based facilities are summarized. Even though ground-based facilities offer a relatively short experiment time, this available test time has been found to be sufficient to advance the scientific understanding of many phenomena and to provide meaningful hardware tests during the flight experiment development process. Also, since experiments can be quickly repeated in these facilities, multistep phenomena that have longer characteristic times associated with them can sometimes be examined in a step-by-step process. There is a large body of literature which has reported the study results achieved through using reduced-gravity data obtained from the facilities.

Payload/cargo processing at the launch site

NASA Technical Reports Server (NTRS)

Ragusa, J. M.

1983-01-01

Payload processing at Kennedy Space Center is described, with emphasis on payload contamination control. Support requirements are established after documentation of the payload. The processing facilities feature enclosed, environmentally controlled conditions, with account taken of the weather conditions, door openings, accessing the payload, industrial activities, and energy conservation. Apparatus are also available for purges after Orbiter landing. The payloads are divided into horizontal, vertical, mixed, and life sciences and Getaway Special categories, which determines the processing route through the facilities. A canister/transport system features sealed containers for moving payloads from one facility building to another. All payloads are exposed to complete Orbiter bay interface checkouts in a simulator before actually being mounted in the bay.

Monitoring occurrence and persistence of Listeria monocytogenes in foods and food processing environments in the Republic of Ireland.

PubMed

Leong, Dara; Alvarez-Ordóñez, Avelino; Jordan, Kieran

2014-01-01

Although rates of listeriosis are low in comparison to other foodborne pathogenic illness, listeriosis poses a significant risk to human health as the invasive form can have a mortality rate as high as 30%. Food processors, especially those who produce ready-to-eat (RTE) products, need to be vigilant against Listeria monocytogenes, the causative pathogen of listeriosis, and as such, the occurrence of L. monocytogenes in food and in the food processing environment needs to be carefully monitored. To examine the prevalence and patterns of contamination in food processing facilities in Ireland, 48 food processors submitted 8 samples every 2 months from March 2013 to March 2014 to be analyzed for L. monocytogenes. No positive samples were detected at 38% of the processing facilities tested. Isolates found at the remaining 62% of facilities were characterized by serotyping and Pulsed Field Gel Electrophoresis (PFGE). A general L. monocytogenes prevalence of 4.6% was seen in all samples analyzed with similar rates seen in food and environmental samples. Differences in prevalence were seen across different food processors, food sectors, sampling months etc. and PFGE analysis allowed for the examination of contamination patterns and for the identification of several persistent strains. Seven of the food processing facilities tested showed contamination with persistent strains and evidence of bacterial transfer from the processing environment to food (the same pulsotype found in both) was seen in four of the food processing facilities tested.

Monitoring occurrence and persistence of Listeria monocytogenes in foods and food processing environments in the Republic of Ireland

PubMed Central

Leong, Dara; Alvarez-Ordóñez, Avelino; Jordan, Kieran

2014-01-01

Although rates of listeriosis are low in comparison to other foodborne pathogenic illness, listeriosis poses a significant risk to human health as the invasive form can have a mortality rate as high as 30%. Food processors, especially those who produce ready-to-eat (RTE) products, need to be vigilant against Listeria monocytogenes, the causative pathogen of listeriosis, and as such, the occurrence of L. monocytogenes in food and in the food processing environment needs to be carefully monitored. To examine the prevalence and patterns of contamination in food processing facilities in Ireland, 48 food processors submitted 8 samples every 2 months from March 2013 to March 2014 to be analyzed for L. monocytogenes. No positive samples were detected at 38% of the processing facilities tested. Isolates found at the remaining 62% of facilities were characterized by serotyping and Pulsed Field Gel Electrophoresis (PFGE). A general L. monocytogenes prevalence of 4.6% was seen in all samples analyzed with similar rates seen in food and environmental samples. Differences in prevalence were seen across different food processors, food sectors, sampling months etc. and PFGE analysis allowed for the examination of contamination patterns and for the identification of several persistent strains. Seven of the food processing facilities tested showed contamination with persistent strains and evidence of bacterial transfer from the processing environment to food (the same pulsotype found in both) was seen in four of the food processing facilities tested. PMID:25191314

Material Processing Facility - Skylab Experiment M512

NASA Technical Reports Server (NTRS)

1972-01-01

This chart details Skylab's Materials Processing Facility experiment (M512). This facility, located in the Multiple Docking Adapter, was developed for Skylab and accommodated 14 different experiments that were carried out during the three marned missions. The abilities to melt and mix without the contaminating effects of containers, to suppress thermal convection and buoyancy in fluids, and to take advantage of electrostatic and magnetic forces and otherwise masked by gravitation opened the way to new knowledge of material properties and processes. This beginning would ultimately lead to the production of valuable new materials for use on Earth.

Walk-through survey report: Control technology for integrated circuit fabrication, Xerox Corporation, El Segundo, California

NASA Astrophysics Data System (ADS)

Mihlan, G. J.; Ungers, L. J.; Smith, R. K.; Mitchell, R. I.; Jones, J. H.

1983-05-01

A preliminary control technology assessment survey was conducted at the facility which manufactures N-channel metal oxide semiconductor (NMOS) integrated circuits. The facility has industrial hygiene review procedures for evaluating all new and existing process equipment. Employees are trained in safety, use of personal protective equipment, and emergency response. Workers potentially exposed to arsenic are monitored for urinary arsenic levels. The facility should be considered a candidate for detailed study based on the diversity of process operations encountered and the use of state-of-the-art technology and process equipment.

Skylab materials processing facility experiment developer's report

NASA Technical Reports Server (NTRS)

Parks, P. G.

1975-01-01

The development of the Skylab M512 Materials Processing Facility is traced from the design of a portable, self-contained electron beam welding system for terrestrial applications to the highly complex experiment system ultimately developed for three Skylab missions. The M512 experiment facility was designed to support six in-space experiments intended to explore the advantages of manufacturing materials in the near-zero-gravity environment of Earth orbit. Detailed descriptions of the M512 facility and related experiment hardware are provided, with discussions of hardware verification and man-machine interfaces included. An analysis of the operation of the facility and experiments during the three Skylab missions is presented, including discussions of the hardware performance, anomalies, and data returned to earth.

Spent nuclear fuel project cold vacuum drying facility operations manual

DOE Office of Scientific and Technical Information (OSTI.GOV)

IRWIN, J.J.

This document provides the Operations Manual for the Cold Vacuum Drying Facility (CVDF). The Manual was developed in conjunction with HNF-SD-SNF-SAR-002, Safety Analysis Report for the Cold Vacuum Drying Facility, Phase 2, Supporting Installation of Processing Systems (Garvin 1998) and, the HNF-SD-SNF-DRD-002, 1997, Cold Vacuum Drying Facility Design Requirements, Rev. 3a. The Operations Manual contains general descriptions of all the process, safety and facility systems in the CVDF, a general CVD operations sequence, and has been developed for the SNFP Operations Organization and shall be updated, expanded, and revised in accordance with future design, construction and startup phases of themore » CVDF until the CVDF final ORR is approved.« less

KSC-04pd1697

NASA Image and Video Library

2004-09-01

KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, workers prepare to close the payload bay doors on Atlantis in preparation for the expected impact of Hurricane Frances on Saturday. Other preparations at KSC include powering down the Space Shuttle orbiters and stowing the landing gear. Workers are also taking precautions against flooding by moving spacecraft hardware off the ground and sandbagging facilities. The Orbiter Processing Facility is constructed of concrete and steel and was designed to withstand winds of 105 mph. The Vehicle Assembly Building is constructed of concrete and steel and was designed to withstand winds of 125 mph. Other payload and flight hardware support facilities can endure winds of 110 mph. Launch pads and the Payload Hazardous Servicing Facility can withstand 125-mph winds.

KSC-04pd1692

NASA Image and Video Library

2004-08-31

KENNEDY SPACE CENTER, FLA. - Workers in the Orbiter Processing Facility prepare to stow the landing gear on the orbiter Atlantis in preparation for the expected impact of Hurricane Frances on Saturday. Other preparations at KSC include powering down the Space Shuttle orbiters, and closing their payload bay doors. Workers are also taking precautions against flooding by moving spacecraft hardware off the ground and sandbagging facilities. The Orbiter Processing Facility is constructed of concrete and steel and was designed to withstand winds of 105 mph. The Vehicle Assembly Building is constructed of concrete and steel and was designed to withstand winds of 125 mph. Other payload and flight hardware support facilities can endure winds of 110 mph. Launch pads and the Payload Hazardous Servicing Facility can withstand 125-mph winds.

KSC-04pd1694

NASA Image and Video Library

2004-08-31

KENNEDY SPACE CENTER, FLA. - Workers in the Orbiter Processing Facility prepare the wheel bay to stow Atlantis’ landing gear in preparation for the expected impact of Hurricane Frances on Saturday. Other preparations at KSC include powering down the Space Shuttle orbiters, and closing their payload bay doors. Workers are also taking precautions against flooding by moving spacecraft hardware off the ground and sandbagging facilities. The Orbiter Processing Facility is constructed of concrete and steel and was designed to withstand winds of 105 mph. The Vehicle Assembly Building is constructed of concrete and steel and was designed to withstand winds of 125 mph. Other payload and flight hardware support facilities can endure winds of 110 mph. Launch pads and the Payload Hazardous Servicing Facility can withstand 125-mph winds.

KSC-04pd1711

NASA Image and Video Library

2004-09-01

KENNEDY SPACE CENTER, FLA. - Workers in the Orbiter Processing Facility finish Hurricane preparations on the payload bay doors of Atlantis. Preparing for the expected impact of Hurricane Frances on Saturday, workers also powered down the Space Shuttle orbiters, and stowed the landing gear. They are also taking precautions against flooding by moving spacecraft hardware off the ground and sandbagging facilities. The Orbiter Processing Facility is constructed of concrete and steel and was designed to withstand winds of 105 mph. The Vehicle Assembly Building is constructed of concrete and steel and was designed to withstand winds of 125 mph. Other payload and flight hardware support facilities can endure winds of 110 mph. Launch pads and the Payload Hazardous Servicing Facility can withstand 125-mph winds.

KSC-04pd1691

NASA Image and Video Library

2004-08-31

KENNEDY SPACE CENTER, FLA. - Workers in the Orbiter Processing Facility prepare to close the nose wheel doors on Atlantis in preparation for the expected impact of Hurricane Frances on Saturday. Preparations at KSC include powering down the Space Shuttle orbiters, closing their payload bay doors and stowing their landing gear. They are also taking precautions against flooding by moving spacecraft hardware off the ground and sandbagging facilities. The Orbiter Processing Facility is constructed of concrete and steel and was designed to withstand winds of 105 mph. The Vehicle Assembly Building is constructed of concrete and steel and was designed to withstand winds of 125 mph. Other payload and flight hardware support facilities can endure winds of 110 mph. Launch pads and the Payload Hazardous Servicing Facility can withstand 125-mph winds.

KSC-04pd1688

NASA Image and Video Library

2004-08-31

KENNEDY SPACE CENTER, FLA. - Workers in the Orbiter Processing Facility prepare the orbiter Atlantis and related equipment for the expected impact of Hurricane Frances on Saturday. Preparations at KSC include powering down the Space Shuttle orbiters, closing their payload bay doors and stowing their landing gear. They are also taking precautions against flooding by moving spacecraft hardware off the ground and sandbagging facilities. The Orbiter Processing Facility is constructed of concrete and steel and was designed to withstand winds of 105 mph. The Vehicle Assembly Building is constructed of concrete and steel and was designed to withstand winds of 125 mph. Other payload and flight hardware support facilities can endure winds of 110 mph. Launch pads and the Payload Hazardous Servicing Facility can withstand 125-mph winds.

KSC-04pd1703

NASA Image and Video Library

2004-09-01

KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, the payload bay doors on Atlantis are being closed in preparation for the expected impact of Hurricane Frances on Saturday. Other preparations at KSC include powering down the Space Shuttle orbiters and stowing the landing gear. Workers are also taking precautions against flooding by moving spacecraft hardware off the ground and sandbagging facilities. The Orbiter Processing Facility is constructed of concrete and steel and was designed to withstand winds of 105 mph. The Vehicle Assembly Building is constructed of concrete and steel and was designed to withstand winds of 125 mph. Other payload and flight hardware support facilities can endure winds of 110 mph. Launch pads and the Payload Hazardous Servicing Facility can withstand 125-mph winds.

KSC-04pd1710

NASA Image and Video Library

2004-09-01

KENNEDY SPACE CENTER, FLA. - Workers in the Orbiter Processing Facility cover up areas of Atlantis with plastic, preparing for the expected impact of Hurricane Frances on Saturday. Other preparations at KSC include powering down the Space Shuttle orbiters, closing the payload bay doors and stowing the landing gear. Workers are also taking precautions against flooding by moving spacecraft hardware off the ground and sandbagging facilities. The Orbiter Processing Facility is constructed of concrete and steel and was designed to withstand winds of 105 mph. The Vehicle Assembly Building is constructed of concrete and steel and was designed to withstand winds of 125 mph. Other payload and flight hardware support facilities can endure winds of 110 mph. Launch pads and the Payload Hazardous Servicing Facility can withstand 125-mph winds.

KSC-04pd1693

NASA Image and Video Library

2004-08-31

KENNEDY SPACE CENTER, FLA. - Workers in the Orbiter Processing Facility prepare to stow the landing gear on the orbiter Atlantis in preparation for the expected impact of Hurricane Frances on Saturday. Other preparations at KSC include powering down the Space Shuttle orbiters, and closing their payload bay doors. Workers are also taking precautions against flooding by moving spacecraft hardware off the ground and sandbagging facilities. The Orbiter Processing Facility is constructed of concrete and steel and was designed to withstand winds of 105 mph. The Vehicle Assembly Building is constructed of concrete and steel and was designed to withstand winds of 125 mph. Other payload and flight hardware support facilities can endure winds of 110 mph. Launch pads and the Payload Hazardous Servicing Facility can withstand 125-mph winds.

KSC-04pd1699

NASA Image and Video Library

2004-09-01

KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, Atlantis’ payload bay doors are being closed in preparation for the expected impact of Hurricane Frances on Saturday. Other preparations at KSC include powering down the Space Shuttle orbiters and stowing the landing gear. Workers are also taking precautions against flooding by moving spacecraft hardware off the ground and sandbagging facilities. The Orbiter Processing Facility is constructed of concrete and steel and was designed to withstand winds of 105 mph. The Vehicle Assembly Building is constructed of concrete and steel and was designed to withstand winds of 125 mph. Other payload and flight hardware support facilities can endure winds of 110 mph. Launch pads and the Payload Hazardous Servicing Facility can withstand 125-mph winds.

KSC-04pd1698

NASA Image and Video Library

2004-09-01

KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, workers prepare to close the payload bay doors on Atlantis in preparation for the expected impact of Hurricane Frances on Saturday. Other preparations at KSC include powering down the Space Shuttle orbiters and stowing the landing gear. Workers are also taking precautions against flooding by moving spacecraft hardware off the ground and sandbagging facilities. The Orbiter Processing Facility is constructed of concrete and steel and was designed to withstand winds of 105 mph. The Vehicle Assembly Building is constructed of concrete and steel and was designed to withstand winds of 125 mph. Other payload and flight hardware support facilities can endure winds of 110 mph. Launch pads and the Payload Hazardous Servicing Facility can withstand 125-mph winds.

KSC-04pd1690

NASA Image and Video Library

2004-08-31

KENNEDY SPACE CENTER, FLA. - Workers in the Orbiter Processing Facility prepare to close the nose wheel doors on Atlantis in preparation for the expected impact of Hurricane Frances on Saturday. Preparations at KSC include powering down the Space Shuttle orbiters, closing their payload bay doors and stowing their landing gear. They are also taking precautions against flooding by moving spacecraft hardware off the ground and sandbagging facilities. The Orbiter Processing Facility is constructed of concrete and steel and was designed to withstand winds of 105 mph. The Vehicle Assembly Building is constructed of concrete and steel and was designed to withstand winds of 125 mph. Other payload and flight hardware support facilities can endure winds of 110 mph. Launch pads and the Payload Hazardous Servicing Facility can withstand 125-mph winds.

KSC-04pd1689

NASA Image and Video Library

2004-08-31

KENNEDY SPACE CENTER, FLA. - Workers in the Orbiter Processing Facility prepare to close the nose wheel doors on Atlantis in preparation for the expected impact of Hurricane Frances on Saturday. Preparations at KSC include powering down the Space Shuttle orbiters, closing their payload bay doors and stowing their landing gear. They are also taking precautions against flooding by moving spacecraft hardware off the ground and sandbagging facilities. The Orbiter Processing Facility is constructed of concrete and steel and was designed to withstand winds of 105 mph. The Vehicle Assembly Building is constructed of concrete and steel and was designed to withstand winds of 125 mph. Other payload and flight hardware support facilities can endure winds of 110 mph. Launch pads and the Payload Hazardous Servicing Facility can withstand 125-mph winds.

KSC-04pd1708

NASA Image and Video Library

2004-09-01

KENNEDY SPACE CENTER, FLA. - Workers in the Orbiter Processing Facility cover up areas of Atlantis, preparing for the expected impact of Hurricane Frances on Saturday. Other preparations at KSC include powering down the Space Shuttle orbiters, closing the payload bay doors and stowing the landing gear. Workers are also taking precautions against flooding by moving spacecraft hardware off the ground and sandbagging facilities. The Orbiter Processing Facility is constructed of concrete and steel and was designed to withstand winds of 105 mph. The Vehicle Assembly Building is constructed of concrete and steel and was designed to withstand winds of 125 mph. Other payload and flight hardware support facilities can endure winds of 110 mph. Launch pads and the Payload Hazardous Servicing Facility can withstand 125-mph winds.

KSC-04pd1702

NASA Image and Video Library

2004-09-01

KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, the payload bay doors on Atlantis are being closed in preparation for the expected impact of Hurricane Frances on Saturday. Other preparations at KSC include powering down the Space Shuttle orbiters and stowing the landing gear. Workers are also taking precautions against flooding by moving spacecraft hardware off the ground and sandbagging facilities. The Orbiter Processing Facility is constructed of concrete and steel and was designed to withstand winds of 105 mph. The Vehicle Assembly Building is constructed of concrete and steel and was designed to withstand winds of 125 mph. Other payload and flight hardware support facilities can endure winds of 110 mph. Launch pads and the Payload Hazardous Servicing Facility can withstand 125-mph winds.

KSC-04pd1700

NASA Image and Video Library

2004-09-01

KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, the payload bay doors on Atlantis are being closed in preparation for the expected impact of Hurricane Frances on Saturday. Other preparations at KSC include powering down the Space Shuttle orbiters and stowing the landing gear. Workers are also taking precautions against flooding by moving spacecraft hardware off the ground and sandbagging facilities. The Orbiter Processing Facility is constructed of concrete and steel and was designed to withstand winds of 105 mph. The Vehicle Assembly Building is constructed of concrete and steel and was designed to withstand winds of 125 mph. Other payload and flight hardware support facilities can endure winds of 110 mph. Launch pads and the Payload Hazardous Servicing Facility can withstand 125-mph winds.

KSC-04pd1696

NASA Image and Video Library

2004-08-31

KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, Atlantis’ wheels are raised into their wheel bays in preparation for the expected impact of Hurricane Frances on Saturday. Other preparations at KSC include powering down the Space Shuttle orbiters, and closing their payload bay doors. Workers are also taking precautions against flooding by moving spacecraft hardware off the ground and sandbagging facilities. The Orbiter Processing Facility is constructed of concrete and steel and was designed to withstand winds of 105 mph. The Vehicle Assembly Building is constructed of concrete and steel and was designed to withstand winds of 125 mph. Other payload and flight hardware support facilities can endure winds of 110 mph. Launch pads and the Payload Hazardous Servicing Facility can withstand 125-mph winds.

KSC-04pd1704

NASA Image and Video Library

2004-09-01

KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, the payload bay doors on Atlantis are being closed in preparation for the expected impact of Hurricane Frances on Saturday. Other preparations at KSC include powering down the Space Shuttle orbiters and stowing the landing gear. Workers are also taking precautions against flooding by moving spacecraft hardware off the ground and sandbagging facilities. The Orbiter Processing Facility is constructed of concrete and steel and was designed to withstand winds of 105 mph. The Vehicle Assembly Building is constructed of concrete and steel and was designed to withstand winds of 125 mph. Other payload and flight hardware support facilities can endure winds of 110 mph. Launch pads and the Payload Hazardous Servicing Facility can withstand 125-mph winds.

KSC-04pd1701

NASA Image and Video Library

2004-09-01

KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, a worker checks out part of Atlantis after payload bay doors were closed in preparation for the expected impact of Hurricane Frances on Saturday. Other preparations at KSC include powering down the Space Shuttle orbiters and stowing the landing gear. Workers are also taking precautions against flooding by moving spacecraft hardware off the ground and sandbagging facilities. The Orbiter Processing Facility is constructed of concrete and steel and was designed to withstand winds of 105 mph. The Vehicle Assembly Building is constructed of concrete and steel and was designed to withstand winds of 125 mph. Other payload and flight hardware support facilities can endure winds of 110 mph. Launch pads and the Payload Hazardous Servicing Facility can withstand 125-mph winds.

KSC-04pd1695

NASA Image and Video Library

2004-08-31

KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, Atlantis’ wheels are raised into their wheel bays in preparation for the expected impact of Hurricane Frances on Saturday. Other preparations at KSC include powering down the Space Shuttle orbiters, and closing their payload bay doors. Workers are also taking precautions against flooding by moving spacecraft hardware off the ground and sandbagging facilities. The Orbiter Processing Facility is constructed of concrete and steel and was designed to withstand winds of 105 mph. The Vehicle Assembly Building is constructed of concrete and steel and was designed to withstand winds of 125 mph. Other payload and flight hardware support facilities can endure winds of 110 mph. Launch pads and the Payload Hazardous Servicing Facility can withstand 125-mph winds.

KSC-04pd1709

NASA Image and Video Library

2004-09-01

KENNEDY SPACE CENTER, FLA. - Workers in the Orbiter Processing Facility cover up areas of Atlantis with plastic, preparing for the expected impact of Hurricane Frances on Saturday. Other preparations at KSC include powering down the Space Shuttle orbiters, closing the payload bay doors and stowing the landing gear. Workers are also taking precautions against flooding by moving spacecraft hardware off the ground and sandbagging facilities. The Orbiter Processing Facility is constructed of concrete and steel and was designed to withstand winds of 105 mph. The Vehicle Assembly Building is constructed of concrete and steel and was designed to withstand winds of 125 mph. Other payload and flight hardware support facilities can endure winds of 110 mph. Launch pads and the Payload Hazardous Servicing Facility can withstand 125-mph winds.

40 CFR 60.480 - Applicability and designation of affected facility.

Code of Federal Regulations, 2010 CFR

2010-07-01

... subpart. (c) Addition or replacement of equipment for the purpose of process improvement which is... all equipment (defined in § 60.481) within a process unit is an affected facility. (b) Any affected... the definition of “process unit” in § 60.481 and the requirements in § 60.482-1(g) of this subpart...

Impact of Salt Waste Processing Facility Streams on the Nitric-Glycolic Flowsheet in the Chemical Processing Cell

DOE Office of Scientific and Technical Information (OSTI.GOV)

Martino, C.

An evaluation of the previous Chemical Processing Cell (CPC) testing was performed to determine whether the planned concurrent operation, or “coupled” operations, of the Defense Waste Processing Facility (DWPF) with the Salt Waste Processing Facility (SWPF) has been adequately covered. Tests with the nitricglycolic acid flowsheet, which were both coupled and uncoupled with salt waste streams, included several tests that required extended boiling times. This report provides the evaluation of previous testing and the testing recommendation requested by Savannah River Remediation. The focus of the evaluation was impact on flammability in CPC vessels (i.e., hydrogen generation rate, SWPF solvent components,more » antifoam degradation products) and processing impacts (i.e., acid window, melter feed target, rheological properties, antifoam requirements, and chemical composition).« less

A New Concept: Use of Negotiations in the Hazardous Waste Facility Permitting Process in New Mexico

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnson, G.J.; Rose, W.M.; Domenici, P.V.

This paper describes a unique negotiation process leading to authorization of the U.S. Department of Energy (DOE) to manage and dispose remote-handled (RH) transuranic (TRU) mixed wastes at the Waste Isolation Pilot Plant (WIPP). The negotiation process involved multiple entities and individuals brought together under authority of the New Mexico Environment Department (NMED) to discuss and resolve technical and facility operational issues flowing from an NMED-issued hazardous waste facility Draft Permit. The novel negotiation process resulted in numerous substantive changes to the Draft Permit, which were ultimately memorialised in a 'Draft Permit as Changed'. This paper discusses various aspects ofmore » the negotiation process, including events leading to the negotiations, regulatory basis for the negotiations, negotiation participants, and benefits of the process. (authors)« less

New Ideas on Facilities Management.

ERIC Educational Resources Information Center

Grimm, James C.

1986-01-01

Examines trends in facilities management relating to products and people. Reviews new trends in products, including processes, techniques, and programs that are being expounded by business and industry. Discusses the "people factors" involved in facilities management. (ABB)

Steel Pickling Inspection Checklist

EPA Pesticide Factsheets

Checklist to establish whether a facility or operations within a facility are subject to and are in compliance with 40 C.F.R Part 63 Subpart CCC (Steel Pickling—HCl Process Facilities and Hydrochloric Acid Regeneration Plants NESHAP).

Team processes in airway facilities operations control centers.

DOT National Transportation Integrated Search

2000-07-01

In October 2000, the Airway Facilities organization plans to transition the National Airspace System (NAS) monitoring responsibilities to three regional Operations Control Centers (OCCs). Teams in these facilities will be different from those that cu...

How work context affects operating room processes: using data mining and computer simulation to analyze facility and process design.

PubMed

Baumgart, André; Denz, Christof; Bender, Hans-Joachim; Schleppers, Alexander

2009-01-01

The complexity of the operating room (OR) requires that both structural (eg, department layout) and behavioral (eg, staff interactions) patterns of work be considered when developing quality improvement strategies. In our study, we investigated how these contextual factors influence outpatient OR processes and the quality of care delivered. The study setting was a German university-affiliated hospital performing approximately 6000 outpatient surgeries annually. During the 3-year-study period, the hospital significantly changed its outpatient OR facility layout from a decentralized (ie, ORs in adjacent areas of the building) to a centralized (ie, ORs in immediate vicinity of each other) design. To study the impact of the facility change on OR processes, we used a mixed methods approach, including process analysis, process modeling, and social network analysis of staff interactions. The change in facility layout was seen to influence OR processes in ways that could substantially affect patient outcomes. For example, we found a potential for more errors during handovers in the new centralized design due to greater interdependency between tasks and staff. Utilization of the mixed methods approach in our analysis, as compared with that of a single assessment method, enabled a deeper understanding of the OR work context and its influence on outpatient OR processes.

Remote Internet access to advanced analytical facilities: a new approach with Web-based services.

PubMed

Sherry, N; Qin, J; Fuller, M Suominen; Xie, Y; Mola, O; Bauer, M; McIntyre, N S; Maxwell, D; Liu, D; Matias, E; Armstrong, C

2012-09-04

Over the past decade, the increasing availability of the World Wide Web has held out the possibility that the efficiency of scientific measurements could be enhanced in cases where experiments were being conducted at distant facilities. Examples of early successes have included X-ray diffraction (XRD) experimental measurements of protein crystal structures at synchrotrons and access to scanning electron microscopy (SEM) and NMR facilities by users from institutions that do not possess such advanced capabilities. Experimental control, visual contact, and receipt of results has used some form of X forwarding and/or VNC (virtual network computing) software that transfers the screen image of a server at the experimental site to that of the users' home site. A more recent development is a web services platform called Science Studio that provides teams of scientists with secure links to experiments at one or more advanced research facilities. The software provides a widely distributed team with a set of controls and screens to operate, observe, and record essential parts of the experiment. As well, Science Studio provides high speed network access to computing resources to process the large data sets that are often involved in complex experiments. The simple web browser and the rapid transfer of experimental data to a processing site allow efficient use of the facility and assist decision making during the acquisition of the experimental results. The software provides users with a comprehensive overview and record of all parts of the experimental process. A prototype network is described involving X-ray beamlines at two different synchrotrons and an SEM facility. An online parallel processing facility has been developed that analyzes the data in near-real time using stream processing. Science Studio and can be expanded to include many other analytical applications, providing teams of users with rapid access to processed results along with the means for detailed discussion of their significance.

Fact Sheet - Final Air Toxics Rule for Steel Pickling and HCI Process Facilities and Hydrochloric Acid Regeneration Plants

EPA Pesticide Factsheets

Fact Sheet summarizing the main points of the national emssions standard for hazaradous air pollutants (NESHAP) for Steel Pickling— HCl Process Facilities and Hydrochloric Acid Regeneration Plants as promulgated on June 22, 1999.

77 FR 48992 - Tobacco Product Manufacturing Facility Visits

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-15

... manufacturing operations--from the receipt of raw materials to the distribution of finished products, and Learn... Manufacturing facilities for materials used for further processing in finished tobacco products (including, but..., parts, accessories, and Manufacturers of materials used for further processing in finished tobacco...

77 FR 6122 - Providing Refurbishment Services to Federal Agencies

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-07

... equipment? 5. Describe the process for disposing and recycling of failed equipment. Have all facilities in your recycling and disposal process been certified to safely recycle and manage electronics? If so... firms offering refurbishment services, including those developed specifically for recycling facilities...

47 CFR 73.1615 - Operation during modification of facilities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 4 2010-10-01 2010-10-01 false Operation during modification of facilities. 73... modification of facilities. When the licensee of an existing AM, FM, TV or Class A TV station is in the process of modifying existing facilities as authorized by a construction permit and determines it is...

9 CFR 590.506 - Candling and transfer-room facilities and equipment.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Candling and transfer-room facilities... INSPECTION ACT) Sanitary, Processing, and Facility Requirements § 590.506 Candling and transfer-room facilities and equipment. (a) The room shall be so constructed that it can be adequately darkened to assure...

9 CFR 590.506 - Candling and transfer-room facilities and equipment.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Candling and transfer-room facilities... INSPECTION ACT) Sanitary, Processing, and Facility Requirements § 590.506 Candling and transfer-room facilities and equipment. (a) The room shall be so constructed that it can be adequately darkened to assure...

9 CFR 590.506 - Candling and transfer-room facilities and equipment.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Candling and transfer-room facilities... INSPECTION ACT) Sanitary, Processing, and Facility Requirements § 590.506 Candling and transfer-room facilities and equipment. (a) The room shall be so constructed that it can be adequately darkened to assure...

9 CFR 590.506 - Candling and transfer-room facilities and equipment.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Candling and transfer-room facilities... INSPECTION ACT) Sanitary, Processing, and Facility Requirements § 590.506 Candling and transfer-room facilities and equipment. (a) The room shall be so constructed that it can be adequately darkened to assure...

Methane Emissions from United States Natural Gas Gathering and Processing.

PubMed

Marchese, Anthony J; Vaughn, Timothy L; Zimmerle, Daniel J; Martinez, David M; Williams, Laurie L; Robinson, Allen L; Mitchell, Austin L; Subramanian, R; Tkacik, Daniel S; Roscioli, Joseph R; Herndon, Scott C

2015-09-01

New facility-level methane (CH4) emissions measurements obtained from 114 natural gas gathering facilities and 16 processing plants in 13 U.S. states were combined with facility counts obtained from state and national databases in a Monte Carlo simulation to estimate CH4 emissions from U.S. natural gas gathering and processing operations. Total annual CH4 emissions of 2421 (+245/-237) Gg were estimated for all U.S. gathering and processing operations, which represents a CH4 loss rate of 0.47% (±0.05%) when normalized by 2012 CH4 production. Over 90% of those emissions were attributed to normal operation of gathering facilities (1697 +189/-185 Gg) and processing plants (506 +55/-52 Gg), with the balance attributed to gathering pipelines and processing plant routine maintenance and upsets. The median CH4 emissions estimate for processing plants is a factor of 1.7 lower than the 2012 EPA Greenhouse Gas Inventory (GHGI) estimate, with the difference due largely to fewer reciprocating compressors, and a factor of 3.0 higher than that reported under the EPA Greenhouse Gas Reporting Program. Since gathering operations are currently embedded within the production segment of the EPA GHGI, direct comparison to our results is complicated. However, the study results suggest that CH4 emissions from gathering are substantially higher than the current EPA GHGI estimate and are equivalent to 30% of the total net CH4 emissions in the natural gas systems GHGI. Because CH4 emissions from most gathering facilities are not reported under the current rule and not all source categories are reported for processing plants, the total CH4 emissions from gathering and processing reported under the EPA GHGRP (180 Gg) represents only 14% of that tabulated in the EPA GHGI and 7% of that predicted from this study.

40 CFR 1068.20 - May EPA enter my facilities for inspections?

Code of Federal Regulations, 2010 CFR

2010-07-01

..., manufacturing processes, storage facilities (including port facilities for imported engines and equipment or... inspect if we learn that local law prohibits it, but we may suspend your certificate if we are not allowed...

Update of KSC activities for the space transportation system

NASA Technical Reports Server (NTRS)

Gray, R. H.

1979-01-01

The paper is a status report on the facilities and planned operations at the Kennedy Space Center (KSC) that will support Space Shuttle launches. The conversion of KSC facilities to support efficient and economical checkout and launch operations in the era of the Space Shuttle is nearing completion. The driving force behind the KSC effort has been the necessity of providing adequate and indispensable facilities and support systems at minimum cost. This required the optimum utilization of existing buildings, equipment and systems, both at KSC and at Air Force property on Cape Canaveral, as well as the construction of two major new facilities and several minor ones. The entirely new structures discussed are the Shuttle Landing Facility and Orbiter Processing Facility. KSC stands ready to provide the rapid reliable economical landing-to-launch processing needed to ensure the success of this new space transportation system.

[Generation and phenotype analysis of zebrafish mutations of obesity-related genes lepr and mc4r].

PubMed

Fei, Fei; Sun, Shao-Yang; Yao, Yu-Xiao; Wang, Xu

2017-02-25

Obesity has become a severe public health problem across the world, and seriously affects the health and life quality of human beings. Here we generated lepr and mc4r mutant zebrafish via the CRISPR/Cas9 technique, and performed morphological and functional characterizations of those mutants. We observed that there was no significant phenotypic difference between homozygous mutants and wild-type controls before 2.5 months post-fertilization (mpf). However, the adult lepr -/- and mc4r -/- individuals displayed increased food intake, heavier weight, and higher body fat percentage, the characteristics of obesity phenotypes. Blood glucose test showed that overfeeding induced significantly impaired glucose tolerance in adult lepr -/- and mc4r -/- zebrafish. Furthermore, we analyzed 76 energy metabolism-related transcripts in lepr -/- and mc4r -/- zebrafish livers by using real-time RT-PCR, and compared the results with the published microarray data of Lep ob/ob mouse livers, and found that the changes in the expression of insulin/IGF signaling (IIS) pathway genes in lepr -/- zebrafish and Lep ob/ob mouse were positively correlated, suggesting that the IIS pathway maintains functional conservation between zebrafish and mammals during the evolution of the obesity-regulating molecule network.

Preliminary technical data summary No. 3 for the Defense Waste Processing Facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Landon, L.F.

1980-05-01

This document presents an update on the best information presently available for the purpose of establishing the basis for the design of a Defense Waste Processing Facility. Objective of this project is to provide a facility to fix the radionuclides present in Savannah River Plant (SRP) high-level liquid waste in a high-integrity form (glass). Flowsheets and material balances reflect the alternate CAB case including the incorporation of low-level supernate in concrete. (DLC)

Chemical processing in geothermal nuclear chimney

DOEpatents

Krikorian, O.H.

1973-10-01

A closed rubble filled nuclear chimney is provided in a subterranean geothermal formation by detonation of a nuclear explosive device therein, with reagent input and product output conduits connecting the chimney cavity with appropriate surface facilities. Such facilities will usually comprise reagent preparation, product recovery and recycle facilities. Proccsses are then conducted in the nuclear chimney which processes are facilitated by temperature, pressure, catalytic and other conditions existent or which are otherwise provided in the nuclear chimney. (auth)

Description of waste pretreatment and interfacing systems dynamic simulation model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Garbrick, D.J.; Zimmerman, B.D.

1995-05-01

The Waste Pretreatment and Interfacing Systems Dynamic Simulation Model was created to investigate the required pretreatment facility processing rates for both high level and low level waste so that the vitrification of tank waste can be completed according to the milestones defined in the Tri-Party Agreement (TPA). In order to achieve this objective, the processes upstream and downstream of the pretreatment facilities must also be included. The simulation model starts with retrieval of tank waste and ends with vitrification for both low level and high level wastes. This report describes the results of three simulation cases: one based on suggestedmore » average facility processing rates, one with facility rates determined so that approximately 6 new DSTs are required, and one with facility rates determined so that approximately no new DSTs are required. It appears, based on the simulation results, that reasonable facility processing rates can be selected so that no new DSTs are required by the TWRS program. However, this conclusion must be viewed with respect to the modeling assumptions, described in detail in the report. Also included in the report, in an appendix, are results of two sensitivity cases: one with glass plant water recycle steams recycled versus not recycled, and one employing the TPA SST retrieval schedule versus a more uniform SST retrieval schedule. Both recycling and retrieval schedule appear to have a significant impact on overall tank usage.« less

KENNEDY SPACE CENTER, FLA. - Dynamac employees (from left) Larry Burns, Debbie Wells and Michelle Crouch talk in a conference room of the Space Life Sciences Lab (SLSL), formerly known as the Space Experiment Research and Processing Laboratory (SERPL). They have been transferring equipment from Hangar L. The new lab is a state-of-the-art facility being built for ISS biotechnology research. Developed as a partnership between NASA-KSC and the State of Florida, NASA’s life sciences contractor will be the primary tenant of the facility, leasing space to conduct flight experiment processing and NASA-sponsored research. About 20 percent of the facility will be available for use by Florida’s university researchers through the Florida Space Research Institute.

NASA Image and Video Library

2003-09-10

KENNEDY SPACE CENTER, FLA. - Dynamac employees (from left) Larry Burns, Debbie Wells and Michelle Crouch talk in a conference room of the Space Life Sciences Lab (SLSL), formerly known as the Space Experiment Research and Processing Laboratory (SERPL). They have been transferring equipment from Hangar L. The new lab is a state-of-the-art facility being built for ISS biotechnology research. Developed as a partnership between NASA-KSC and the State of Florida, NASA’s life sciences contractor will be the primary tenant of the facility, leasing space to conduct flight experiment processing and NASA-sponsored research. About 20 percent of the facility will be available for use by Florida’s university researchers through the Florida Space Research Institute.

KENNEDY SPACE CENTER, FLA. - Dynamac employees Debbie Wells, Michelle Crouch and Larry Burns are silhouetted as they talk inside a conference room of the Space Life Sciences Lab (SLSL), formerly known as the Space Experiment Research and Processing Laboratory (SERPL). They have been transferring equipment from Hangar L. The new lab is a state-of-the-art facility being built for ISS biotechnology research. Developed as a partnership between NASA-KSC and the State of Florida, NASA’s life sciences contractor will be the primary tenant of the facility, leasing space to conduct flight experiment processing and NASA-sponsored research. About 20 percent of the facility will be available for use by Florida’s university researchers through the Florida Space Research Institute.

NASA Image and Video Library

2003-09-10

KENNEDY SPACE CENTER, FLA. - Dynamac employees Debbie Wells, Michelle Crouch and Larry Burns are silhouetted as they talk inside a conference room of the Space Life Sciences Lab (SLSL), formerly known as the Space Experiment Research and Processing Laboratory (SERPL). They have been transferring equipment from Hangar L. The new lab is a state-of-the-art facility being built for ISS biotechnology research. Developed as a partnership between NASA-KSC and the State of Florida, NASA’s life sciences contractor will be the primary tenant of the facility, leasing space to conduct flight experiment processing and NASA-sponsored research. About 20 percent of the facility will be available for use by Florida’s university researchers through the Florida Space Research Institute.

KENNEDY SPACE CENTER, FLA. - Ivan Rodriguez, with Bionetics, and Michelle Crouch and Larry Burns, with Dynamac, carry boxes of equipment into the Space Life Sciences Lab (SLSL), formerly known as the Space Experiment Research and Processing Laboratory (SERPL). They are transferring equipment from Hangar L. The new lab is a state-of-the-art facility being built for ISS biotechnology research. Developed as a partnership between NASA-KSC and the State of Florida, NASA’s life sciences contractor will be the primary tenant of the facility, leasing space to conduct flight experiment processing and NASA-sponsored research. About 20 percent of the facility will be available for use by Florida’s university researchers through the Florida Space Research Institute.

NASA Image and Video Library

2003-09-10

KENNEDY SPACE CENTER, FLA. - Ivan Rodriguez, with Bionetics, and Michelle Crouch and Larry Burns, with Dynamac, carry boxes of equipment into the Space Life Sciences Lab (SLSL), formerly known as the Space Experiment Research and Processing Laboratory (SERPL). They are transferring equipment from Hangar L. The new lab is a state-of-the-art facility being built for ISS biotechnology research. Developed as a partnership between NASA-KSC and the State of Florida, NASA’s life sciences contractor will be the primary tenant of the facility, leasing space to conduct flight experiment processing and NASA-sponsored research. About 20 percent of the facility will be available for use by Florida’s university researchers through the Florida Space Research Institute.

KENNEDY SPACE CENTER, FLA. - Dynamac employees (from left) Larry Burns, Debbie Wells and Neil Yorio carry boxes of hardware into the Space Life Sciences Lab (SLSL), formerly known as the Space Experiment Research and Processing Laboratory (SERPL). They are transferring equipment from Hangar L. The new lab is a state-of-the-art facility being built for ISS biotechnology research. Developed as a partnership between NASA-KSC and the State of Florida, NASA’s life sciences contractor will be the primary tenant of the facility, leasing space to conduct flight experiment processing and NASA-sponsored research. About 20 percent of the facility will be available for use by Florida’s university researchers through the Florida Space Research Institute.

NASA Image and Video Library

2003-09-10

KENNEDY SPACE CENTER, FLA. - Dynamac employees (from left) Larry Burns, Debbie Wells and Neil Yorio carry boxes of hardware into the Space Life Sciences Lab (SLSL), formerly known as the Space Experiment Research and Processing Laboratory (SERPL). They are transferring equipment from Hangar L. The new lab is a state-of-the-art facility being built for ISS biotechnology research. Developed as a partnership between NASA-KSC and the State of Florida, NASA’s life sciences contractor will be the primary tenant of the facility, leasing space to conduct flight experiment processing and NASA-sponsored research. About 20 percent of the facility will be available for use by Florida’s university researchers through the Florida Space Research Institute.

NASA Construction of Facilities Validation Processes - Total Building Commissioning (TBCx)

NASA Technical Reports Server (NTRS)

Hoover, Jay C.

2004-01-01

Key Atributes include: Total Quality Management (TQM) System that looks at all phases of a project. A team process that spans boundaries. A Commissioning Authority to lead the process. Commissioning requirements in contracts. Independent design review to verify compliance with Facility Project Requirements (FPR). Formal written Commissioning Plan with Documented Results. Functional performance testing (FPT) against the requirements document.

A Guide for Developing Standard Operating Job Procedures for the Activated Sludge - Aeration & Sedimentation Process Wastewater Treatment Facility. SOJP No. 5.

ERIC Educational Resources Information Center

Mason, George J.

This guide for developing standard operating job procedures for wastewater treatment facilities is devoted to the activated sludge aeration and sedimentation process. This process is for conversion of nonsettleable and nonfloatable materials in wastewater to settleable, floculated biological groups and separation of the settleable solids from the…

A Guide for Developing Standard Operating Job Procedures for the Digestion Process Wastewater Treatment Facility. SOJP No. 10.

ERIC Educational Resources Information Center

Schwing, Carl M.

This guide describes standard operating job procedures for the digestion process of wastewater treatment facilities. This process is for reducing the volume of sludge to be treated in subsequent units and to reduce the volatile content of sludge. The guide gives step-by-step instructions for pre-startup, startup, continuous operating, shutdown,…

300 Area treated effluent disposal facility sampling schedule

DOE Office of Scientific and Technical Information (OSTI.GOV)

Loll, C.M.

1994-10-11

This document is the interface between the 300 Area Liquid Effluent Process Engineering (LEPE) group and the Waste Sampling and Characterization Facility (WSCF), concerning process control samples. It contains a schedule for process control samples at the 300 Area TEDF which describes the parameters to be measured, the frequency of sampling and analysis, the sampling point, and the purpose for each parameter.

Process control and dosimetry in a multipurpose irradiation facility

NASA Astrophysics Data System (ADS)

Cabalfin, E. G.; Lanuza, L. G.; Solomon, H. M.

1999-08-01

Availability of the multipurpose irradiation facility at the Philippine Nuclear Research Institute has encouraged several local industries to use gamma radiation for sterilization or decontamination of various products. Prior to routine processing, dose distribution studies are undertaken for each product and product geometry. During routine irradiation, dosimeters are placed at the minimum and maximum dose positions of a process load.

Applications of Modeling and Simulation for Flight Hardware Processing at Kennedy Space Center

NASA Technical Reports Server (NTRS)

Marshall, Jennifer L.

2010-01-01

The Boeing Design Visualization Group (DVG) is responsible for the creation of highly-detailed representations of both on-site facilities and flight hardware using computer-aided design (CAD) software, with a focus on the ground support equipment (GSE) used to process and prepare the hardware for space. Throughout my ten weeks at this center, I have had the opportunity to work on several projects: the modification of the Multi-Payload Processing Facility (MPPF) High Bay, weekly mapping of the Space Station Processing Facility (SSPF) floor layout, kinematics applications for the Orion Command Module (CM) hatches, and the design modification of the Ares I Upper Stage hatch for maintenance purposes. The main goal of each of these projects was to generate an authentic simulation or representation using DELMIA V5 software. This allowed for evaluation of facility layouts, support equipment placement, and greater process understanding once it was used to demonstrate future processes to customers and other partners. As such, I have had the opportunity to contribute to a skilled team working on diverse projects with a central goal of providing essential planning resources for future center operations.

Chamber B Thermal/Vacuum Chamber: User Test Planning Guide

NASA Technical Reports Server (NTRS)

Montz, Mike E.

2012-01-01

Test process, milestones and inputs are unknowns to first-time users of Chamber B. The User Test Planning Guide aids in establishing expectations for both NASA and non-NASA facility customers. The potential audience for this guide includes both internal and commercial spaceflight hardware/software developers. It is intended to assist their test engineering personnel in test planning and execution. Material covered includes a roadmap of the test process, roles and responsibilities of facility and user, major milestones, facility capabilities, and inputs required by the facility. Samples of deliverables, test article interfaces, and inputs necessary to define test scope, cost, and schedule are included as an appendix to the guide.

Audio Development Laboratory (ADL) User Test Planning Guide

NASA Technical Reports Server (NTRS)

Romero, Andy

2012-01-01

Test process, milestones and inputs are unknowns to first-time users of the ADL. The User Test Planning Guide aids in establishing expectations for both NASA and non-NASA facility customers. The potential audience for this guide includes both internal and commercial spaceflight hardware/software developers. It is intended to assist their test engineering personnel in test planning and execution. Material covered includes a roadmap of the test process, roles and responsibilities of facility and user, major milestones, facility capabilities, and inputs required by the facility. Samples of deliverables, test article interfaces, and inputs necessary to define test scope, cost, and schedule are included as an appendix to the guide.

Electronic Systems Test Laboratory (ESTL) User Test Planning Guide

NASA Technical Reports Server (NTRS)

Robinson, Neil

2011-01-01

Test process, milestones and inputs are unknowns to first-time users of the ESTL. The User Test Planning Guide aids in establishing expectations for both NASA and non-NASA facility customers. The potential audience for this guide includes both internal and commercial spaceflight hardware/software developers. It is intended to assist their test engineering personnel in test planning and execution. Material covered includes a roadmap of the test process, roles and responsibilities of facility and user, major milestones, facility capabilities, and inputs required by the facility. Samples of deliverables, test article interfaces, and inputs necessary to define test scope, cost, and schedule are included as an appendix to the guide.

Perimeter security for Minnesota correctional facilities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Crist, D.; Spencer, D.D.

1996-12-31

For the past few years, the Minnesota Department of Corrections, assisted by Sandia National Laboratories, has developed a set of standards for perimeter security at medium, close, and maximum custody correctional facilities in the state. During this process, the threat to perimeter security was examined and concepts about correctional perimeter security were developed. This presentation and paper will review the outcomes of this effort, some of the lessons learned, and the concepts developed during this process and in the course of working with architects, engineers and construction firms as the state upgraded perimeter security at some facilities and planned newmore » construction at other facilities.« less

Low Gravity Freefall Facilities

NASA Technical Reports Server (NTRS)

1981-01-01

Composite of Marshall Space Flight Center's Low-Gravity Free Fall Facilities.These facilities include a 100-meter drop tower and a 100-meter drop tube. The drop tower simulates in-flight microgravity conditions for up to 4.2 seconds for containerless processing experiments, immiscible fluids and materials research, pre-flight hardware design test and flight experiment simulation. The drop tube simulates in-flight microgravity conditions for up to 4.6 seconds and is used extensively for ground-based microgravity convection research in which extremely small samples are studied. The facility can provide deep undercooling for containerless processing experiments that require materials to remain in a liquid phase when cooled below the normal solidification temperature.

Advanced Materials Laboratory User Test Planning Guide

NASA Technical Reports Server (NTRS)

Orndoff, Evelyne

2012-01-01

Test process, milestones and inputs are unknowns to first-time users of the Advanced Materials Laboratory. The User Test Planning Guide aids in establishing expectations for both NASA and non-NASA facility customers. The potential audience for this guide includes both internal and commercial spaceflight hardware/software developers. It is intended to assist their test engineering personnel in test planning and execution. Material covered includes a roadmap of the test process, roles and responsibilities of facility and user, major milestones, facility capabilities, and inputs required by the facility. Samples of deliverables, test article interfaces, and inputs necessary to define test scope, cost, and schedule are included as an appendix to the guide.

Structures Test Laboratory (STL). User Test Planning Guide

NASA Technical Reports Server (NTRS)

Zipay, John J.

2011-01-01

Test process, milestones and inputs are unknowns to first-time users of the STL. The User Test Planning Guide aids in establishing expectations for both NASA and non-NASA facility customers. The potential audience for this guide includes both internal and commercial spaceflight hardware/software developers. It is intended to assist their test engineering personnel in test planning and execution. Material covered includes a roadmap of the test process, roles and responsibilities of facility and user, major milestones, facility capabilities, and inputs required by the facility. Samples of deliverables, test article interfaces, and inputs necessary to define test scope, cost, and schedule are included as an appendix to the guide.

Vibration isolation in a free-piston driven expansion tube facility

NASA Astrophysics Data System (ADS)

Gildfind, D. E.; Jacobs, P. A.; Morgan, R. G.

2013-09-01

The stress waves produced by rapid piston deceleration are a fundamental feature of free-piston driven expansion tubes, and wave propagation has to be considered in the design process. For lower enthalpy test conditions, these waves can traverse the tube ahead of critical flow processes, severely interfering with static pressure measurements of the passing flow. This paper details a new device which decouples the driven tube from the free-piston driver, and thus prevents transmission of stress waves. Following successful incorporation of the concept in the smaller X2 facility, it has now been applied to the larger X3 facility, and results for both facilities are presented.

Feasibility study of a gamma camera for monitoring nuclear materials in the PRIDE facility

NASA Astrophysics Data System (ADS)

Jo, Woo Jin; Kim, Hyun-Il; An, Su Jung; Lee, Chae Young; Song, Han-Kyeol; Chung, Yong Hyun; Shin, Hee-Sung; Ahn, Seong-Kyu; Park, Se-Hwan

2014-05-01

The Korea Atomic Energy Research Institute (KAERI) has been developing pyroprocessing technology, in which actinides are recovered together with plutonium. There is no pure plutonium stream in the process, so it has an advantage of proliferation resistance. Tracking and monitoring of nuclear materials through the pyroprocess can significantly improve the transparency of the operation and safeguards. An inactive engineering-scale integrated pyroprocess facility, which is the PyRoprocess Integrated inactive DEmonstration (PRIDE) facility, was constructed to demonstrate engineering-scale processes and the integration of each unit process. the PRIDE facility may be a good test bed to investigate the feasibility of a nuclear material monitoring system. In this study, we designed a gamma camera system for nuclear material monitoring in the PRIDE facility by using a Monte Carlo simulation, and we validated the feasibility of this system. Two scenarios, according to locations of the gamma camera, were simulated using GATE (GEANT4 Application for Tomographic Emission) version 6. A prototype gamma camera with a diverging-slat collimator was developed, and the simulated and experimented results agreed well with each other. These results indicate that a gamma camera to monitor the nuclear material in the PRIDE facility can be developed.

PROCESS AND EQUIPMENT CHANGES FOR CLEANER PRODUCTION IN FEDERAL FACILITIES

EPA Science Inventory

The paper discusses process and equipment changes for cleaner production in federal facilities. During the 1990s, DoD and EPA conducted joint research and development, aimed at reducing the discharge of hazardous and toxic pollutants from military production and maintenance faci...

40 CFR 372.20 - Process for modifying covered chemicals and facilities.

Code of Federal Regulations, 2013 CFR

2013-07-01

... chemicals and facilities. 372.20 Section 372.20 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS TOXIC CHEMICAL RELEASE REPORTING: COMMUNITY RIGHT-TO-KNOW Reporting Requirements § 372.20 Process for modifying covered chemicals...

77 FR 42003 - TA-W-81,263, Chartis Global Services, Inc., a Subsidiary of Chartis, Inc., Regional Processing...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-17

... Processing Organization, Regional Service Center, Dallas, TX; Amended Certification Regarding Eligibility To... affiliated facility in Dallas, Texas operated in conjunction with the Houston, Texas facility and were... workers at an affiliated location [[Page 42004

Adjustment of automatic control systems of production facilities at coal processing plants using multivariant physico- mathematical models

NASA Astrophysics Data System (ADS)

Evtushenko, V. F.; Myshlyaev, L. P.; Makarov, G. V.; Ivushkin, K. A.; Burkova, E. V.

2016-10-01

The structure of multi-variant physical and mathematical models of control system is offered as well as its application for adjustment of automatic control system (ACS) of production facilities on the example of coal processing plant.

40 CFR 437.2 - General definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... any facility that treats (for disposal, recycling or recovery of material) any hazardous or non... a facility. (o) Oily absorbent recycling means the process of recycling oil-soaked or contaminated... stock for lubricants or other petroleum products. (y) Recovery means the recycling or processing of a...

40 CFR 437.2 - General definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... any facility that treats (for disposal, recycling or recovery of material) any hazardous or non... a facility. (o) Oily absorbent recycling means the process of recycling oil-soaked or contaminated... stock for lubricants or other petroleum products. (y) Recovery means the recycling or processing of a...

Measuring client satisfaction and the quality of family planning services: A comparative analysis of public and private health facilities in Tanzania, Kenya and Ghana

PubMed Central

2011-01-01

Background Public and private family planning providers face different incentive structures, which may affect overall quality and ultimately the acceptability of family planning for their intended clients. This analysis seeks to quantify differences in the quality of family planning (FP) services at public and private providers in three representative sub-Saharan African countries (Tanzania, Kenya and Ghana), to assess how these quality differentials impact upon FP clients' satisfaction, and to suggest how quality improvements can improve contraceptive continuation rates. Methods Indices of technical, structural and process measures of quality are constructed from Service Provision Assessments (SPAs) conducted in Tanzania (2006), Kenya (2004) and Ghana (2002) using direct observation of facility attributes and client-provider interactions. Marginal effects from multivariate regressions controlling for client characteristics and the multi-stage cluster sample design assess the relative importance of different measures of structural and process quality at public and private facilities on client satisfaction. Results Private health facilities appear to be of higher (interpersonal) process quality than public facilities but not necessarily higher technical quality in the three countries, though these differentials are considerably larger at lower level facilities (clinics, health centers, dispensaries) than at hospitals. Family planning client satisfaction, however, appears considerably higher at private facilities - both hospitals and clinics - most likely attributable to both process and structural factors such as shorter waiting times and fewer stockouts of methods and supplies. Conclusions Because the public sector represents the major source of family planning services in developing countries, governments and Ministries of Health should continue to implement and to encourage incentives, perhaps performance-based, to improve quality at public sector health facilities, as well as to strengthen regulatory and monitoring structures to ensure quality at both public and private facilities. In the meantime, private providers appear to be fulfilling an important gap in the provision of FP services in these countries. PMID:21864335

Measuring client satisfaction and the quality of family planning services: a comparative analysis of public and private health facilities in Tanzania, Kenya and Ghana.

PubMed

Hutchinson, Paul L; Do, Mai; Agha, Sohail

2011-08-24

Public and private family planning providers face different incentive structures, which may affect overall quality and ultimately the acceptability of family planning for their intended clients. This analysis seeks to quantify differences in the quality of family planning (FP) services at public and private providers in three representative sub-Saharan African countries (Tanzania, Kenya and Ghana), to assess how these quality differentials impact upon FP clients' satisfaction, and to suggest how quality improvements can improve contraceptive continuation rates. Indices of technical, structural and process measures of quality are constructed from Service Provision Assessments (SPAs) conducted in Tanzania (2006), Kenya (2004) and Ghana (2002) using direct observation of facility attributes and client-provider interactions. Marginal effects from multivariate regressions controlling for client characteristics and the multi-stage cluster sample design assess the relative importance of different measures of structural and process quality at public and private facilities on client satisfaction. Private health facilities appear to be of higher (interpersonal) process quality than public facilities but not necessarily higher technical quality in the three countries, though these differentials are considerably larger at lower level facilities (clinics, health centers, dispensaries) than at hospitals. Family planning client satisfaction, however, appears considerably higher at private facilities - both hospitals and clinics - most likely attributable to both process and structural factors such as shorter waiting times and fewer stockouts of methods and supplies. Because the public sector represents the major source of family planning services in developing countries, governments and Ministries of Health should continue to implement and to encourage incentives, perhaps performance-based, to improve quality at public sector health facilities, as well as to strengthen regulatory and monitoring structures to ensure quality at both public and private facilities. In the meantime, private providers appear to be fulfilling an important gap in the provision of FP services in these countries.

TA-55 change control manual

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blum, T.W.; Selvage, R.D.; Courtney, K.H.

This manual is the guide for initiating change at the Plutonium Facility, which handles the processing of plutonium as well as research on plutonium metallurgy. It describes the change and work control processes employed at TA-55 to ensure that all proposed changes are properly identified, reviewed, approved, implemented, tested, and documented so that operations are maintained within the approved safety envelope. All Laboratory groups, their contractors, and subcontractors doing work at TA-55 follow requirements set forth herein. This manual applies to all new and modified processes and experiments inside the TA-55 Plutonium Facility; general plant project (GPP) and line itemmore » funded construction projects at TA-55; temporary and permanent changes that directly or indirectly affect structures, systems, or components (SSCs) as described in the safety analysis, including Facility Control System (FCS) software; and major modifications to procedures. This manual does not apply to maintenance performed on process equipment or facility SSCs or the replacement of SSCs or equipment with documented approved equivalents.« less

KENNEDY SPACE CENTER, FLA. - From left, the Consul General of Japan Ko Kodaira, his daughter Reiko, astronaut Dr. Takao Doi, and Kodaira's wife Marie pause for a photograph in the Space Station Processing Facility during their visit to Kennedy Space Center (KSC). Doi represented Japan on Space Shuttle mission STS-87, the fourth U.S Microgravity Payload flight. Kodaira is touring the facilities at KSC at the invitation of the local office of the National Space Development Agency of Japan (NASDA) to acquaint him with KSC's unique processing capabilities.

NASA Image and Video Library

2003-08-26

KENNEDY SPACE CENTER, FLA. - From left, the Consul General of Japan Ko Kodaira, his daughter Reiko, astronaut Dr. Takao Doi, and Kodaira's wife Marie pause for a photograph in the Space Station Processing Facility during their visit to Kennedy Space Center (KSC). Doi represented Japan on Space Shuttle mission STS-87, the fourth U.S Microgravity Payload flight. Kodaira is touring the facilities at KSC at the invitation of the local office of the National Space Development Agency of Japan (NASDA) to acquaint him with KSC's unique processing capabilities.

Mitigating risks related to facilities management.

PubMed

O'Neill, Daniel P; Scarborough, Sydney

2013-07-01

By looking at metrics focusing on the functionality, age, capital investment, transparency, and sustainability (FACTS) of their organizations' facilities, facilities management teams can build potential business cases to justify upgrading the facilities. A FACTS analysis can ensure that capital spent on facilities will produce a higher or more certain ROI than alternatives. A consistent process for managing spending helps to avoid unexpected spikes that cost the enterprise more in the long run.

JSC Metal Finishing Waste Minimization Methods

NASA Technical Reports Server (NTRS)

Sullivan, Erica

2003-01-01

THe paper discusses the following: Johnson Space Center (JSC) has achieved VPP Star status and is ISO 9001 compliant. The Structural Engineering Division in the Engineering Directorate is responsible for operating the metal finishing facility at JSC. The Engineering Directorate is responsible for $71.4 million of space flight hardware design, fabrication and testing. The JSC Metal Finishing Facility processes flight hardware to support the programs in particular schedule and mission critical flight hardware. The JSC Metal Finishing Facility is operated by Rothe Joint Venture. The Facility provides following processes: anodizing, alodining, passivation, and pickling. JSC Metal Finishing Facility completely rebuilt in 1998. Total cost of $366,000. All new tanks, electrical, plumbing, and ventilation installed. Designed to meet modern safety, environmental, and quality requirements. Designed to minimize contamination and provide the highest quality finishes.

Cabana Multi-User Spaceport Tour/CRS-10

NASA Image and Video Library

2017-02-17

Robert Cabana, director of NASA’s Kennedy Space Center, accompanied news media on Friday, February 17 for a three-part tour of facilities in the Launch Complex 39 area at Kennedy. Media received an update on the transition of government facilities to the aerospace industry, and how that approach enables NASA and industry success. The tour included the Vehicle Assembly Building, where extensive work is being completed to prepare not only for NASA’s Space Launch System, but also enables members of the aerospace industry to use the facility between NASA missions. The tour completed at Boeing’s Commercial Crew and Cargo Processing Facility, previously a shuttle processing facility, where the company is manufacturing its Starliner spacecraft for flight tests and ultimately crew rotation missions with NASA’s Commercial Crew Program.

KSC-04pd1707

NASA Image and Video Library

2004-09-01

KENNEDY SPACE CENTER, FLA. - Workers in the Orbiter Processing Facility unwrap plastic for use in covering equipment as part of preparations for the expected impact of Hurricane Frances on Saturday. Other preparations at KSC include powering down the Space Shuttle orbiters, closing the payload bay doors and stowing the landing gear. Workers are also taking precautions against flooding by moving spacecraft hardware off the ground and sandbagging facilities. The Orbiter Processing Facility is constructed of concrete and steel and was designed to withstand winds of 105 mph. The Vehicle Assembly Building is constructed of concrete and steel and was designed to withstand winds of 125 mph. Other payload and flight hardware support facilities can endure winds of 110 mph. Launch pads and the Payload Hazardous Servicing Facility can withstand 125-mph winds.

Steve Nixon | NREL

Science.gov Websites

NREL. Steve has an extensive background in facilities engineering, facilities management, and Energy Manager, and a Project Management Professional. Prior to joining NREL, Steve was the Facilities manufacturing engineering, business application programming, and business process management positions

Throughput Optimization of Continuous Biopharmaceutical Manufacturing Facilities.

PubMed

Garcia, Fernando A; Vandiver, Michael W

2017-01-01

In order to operate profitably under different product demand scenarios, biopharmaceutical companies must design their facilities with mass output flexibility in mind. Traditional biologics manufacturing technologies pose operational challenges in this regard due to their high costs and slow equipment turnaround times, restricting the types of products and mass quantities that can be processed. Modern plant design, however, has facilitated the development of lean and efficient bioprocessing facilities through footprint reduction and adoption of disposable and continuous manufacturing technologies. These development efforts have proven to be crucial in seeking to drastically reduce the high costs typically associated with the manufacturing of recombinant proteins. In this work, mathematical modeling is used to optimize annual production schedules for a single-product commercial facility operating with a continuous upstream and discrete batch downstream platform. Utilizing cell culture duration and volumetric productivity as process variables in the model, and annual plant throughput as the optimization objective, 3-D surface plots are created to understand the effect of process and facility design on expected mass output. The model shows that once a plant has been fully debottlenecked it is capable of processing well over a metric ton of product per year. Moreover, the analysis helped to uncover a major limiting constraint on plant performance, the stability of the neutralized viral inactivated pool, which may indicate that this should be a focus of attention during future process development efforts. LAY ABSTRACT: Biopharmaceutical process modeling can be used to design and optimize manufacturing facilities and help companies achieve a predetermined set of goals. One way to perform optimization is by making the most efficient use of process equipment in order to minimize the expenditure of capital, labor and plant resources. To that end, this paper introduces a novel mathematical algorithm used to determine the most optimal equipment scheduling configuration that maximizes the mass output for a facility producing a single product. The paper also illustrates how different scheduling arrangements can have a profound impact on the availability of plant resources, and identifies limiting constraints on the plant design. In addition, simulation data is presented using visualization techniques that aid in the interpretation of the scientific concepts discussed. © PDA, Inc. 2017.

Monitoring the performances of a real scale municipal solid waste composting and a biodrying facility using respiration activity indices.

PubMed

Evangelou, Alexandros; Gerassimidou, Spyridoula; Mavrakis, Nikitas; Komilis, Dimitrios

2016-05-01

Objective of the work was to monitor two full-scale commingled municipal solid waste (MSW) mechanical and biological pretreatment (MBT) facilities in Greece, namely a biodrying and a composting facility. Monitoring data from a 1.5-year sampling period is presented, whilst microbial respiration indices were used to monitor the decomposition process and the stability status of the wastes in both facilities during the process. Results showed that in the composting facility, the organic matter reduced by 35 % after 8 weeks of combined composting/curing. Material exiting the biocells had a moisture content of less than 30 % (wb) indicating a moisture limitation during the active composting process. The static respiration indexes indicated that some stabilization occurred during the process, but the final material could not be characterized as stable compost. In the biodrying facility, the initial and final moisture contents were 50 % and less than 20 % wb, respectively, and the biodrying index was equal to 4.1 indicating effective biodrying. Lower heating values at the inlet and outlet were approximately 5.5 and 10 MJ/wet kg, respectively. The organic matter was reduced by 20 % during the process and specifically from a range of 63-77 % dw (inlet) to a range of 61-70 % dw. A significant respiration activity reduction was observed for some of the biodrying samples. A statistically significant correlation among all three respiration activity indices was recorded, with the two oxygen related activity indices (CRI7 and SRI24) observing the highest correlation.

Ground based ISS payload microgravity disturbance assessments.

PubMed

McNelis, Anne M; Heese, John A; Samorezov, Sergey; Moss, Larry A; Just, Marcus L

2005-01-01

In order to verify that the International Space Station (ISS) payload facility racks do not disturb the microgravity environment of neighboring facility racks and that the facility science operations are not compromised, a testing and analytical verification process must be followed. Currently no facility racks have taken this process from start to finish. The authors are participants in implementing this process for the NASA Glenn Research Center (GRC) Fluids and Combustion Facility (FCF). To address the testing part of the verification process, the Microgravity Emissions Laboratory (MEL) was developed at GRC. The MEL is a 6 degree of freedom inertial measurement system capable of characterizing inertial response forces (emissions) of components, sub-rack payloads, or rack-level payloads down to 10(-7) g's. The inertial force output data, generated from the steady state or transient operations of the test articles, are utilized in analytical simulations to predict the on-orbit vibratory environment at specific science or rack interface locations. Once the facility payload rack and disturbers are properly modeled an assessment can be made as to whether required microgravity levels are achieved. The modeling is utilized to develop microgravity predictions which lead to the development of microgravity sensitive ISS experiment operations once on-orbit. The on-orbit measurements will be verified by use of the NASA GRC Space Acceleration Measurement System (SAMS). The major topics to be addressed in this paper are: (1) Microgravity Requirements, (2) Microgravity Disturbers, (3) MEL Testing, (4) Disturbance Control, (5) Microgravity Control Process, and (6) On-Orbit Predictions and Verification. Published by Elsevier Ltd.

The used nuclear fuel problem - can reprocessing and consolidated storage be complementary?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Phillips, C.; Thomas, I.

2013-07-01

This paper describes our CISF (Consolidated Interim Storage Facilities) and Reprocessing Facility concepts and show how they can be combined with a geologic repository to provide a comprehensive system for dealing with spent fuels in the USA. The performance of the CISF was logistically analyzed under six operational scenarios. A 3-stage plan has been developed to establish the CISF. Stage 1: the construction at the CISF site of only a rail receipt interface and storage pad large enough for the number of casks that will be received. The construction of the CISF Canister Handling Facility, the Storage Cask Fabrication Facility,more » the Cask Maintenance Facility and supporting infrastructure are performed during stage 2. The construction and placement into operation of a water-filled pool repackaging facility is completed for Stage 3. By using this staged approach, the capital cost of the CISF is spread over a number of years. It also allows more time for a final decision on the geologic repository to be made. A recycling facility will be built, this facility will used the NUEX recycling process that is based on the aqueous-based PUREX solvent extraction process, using a solvent of tri-N-butyl phosphate in a kerosene diluent. It is capable of processing spent fuels at a rate of 5 MT per day, at burn-ups up to 50 GWD per ton of spent fuels and a minimum of 5 years out-of-reactor cooling.« less

Processing loaner instruments in an ambulatory surgery center.

PubMed

Huter-Kunish, Gloria G

2009-05-01

Loaner instruments often do not arrive at receiving facilities in the time frame or the condition that is needed to use them safely. Their cleaning and decontamination status may be unknown. There may be no inventory of what has been loaned or information about processing requirements for the instrument's use. These situations can create problems for both the loaning facility and the receiving facility and must be addressed to reduce costs from damage to or loss of instruments.The use of documents and checklists to verify the cleaning,decontamination, and sterilization processes used allows ambulatory surgery centers to solve these problems,cut costs, and protect staff members and patients.

The Establishment of a New Friction Stir Welding Process Development Facility at NASA/MSFC

NASA Technical Reports Server (NTRS)

Carter, Robert W.

2009-01-01

Full-scale weld process development is being performed at MSFC to develop the tools, fixtures, and facilities necessary for Ares I production. Full scale development in-house at MSFC fosters technical acuity within the NASA engineering community, and allows engineers to identify and correct tooling and equipment shortcomings before they become problems on the production floor. Finally, while the new weld process development facility is currently being outfitted in support of Ares I development, it has been established to support all future Constellation Program needs. In particular, both the RWT and VWT were sized with the larger Ares V hardware in mind.

Microgravity and Materials Processing Facility study (MMPF): Requirements and Analyses of Commercial Operations (RACO) preliminary data release

NASA Technical Reports Server (NTRS)

1988-01-01

This requirements and analyses of commercial operations (RACO) study data release reflects the current status of research activities of the Microgravity and Materials Processing Facility under Modification No. 21 to NASA/MSFC Contract NAS8-36122. Section 1 includes 65 commercial space processing projects suitable for deployment aboard the Space Station. Section 2 contains reports of the R:BASE (TM) electronic data base being used in the study, synopses of the experiments, and a summary of data on the experimental facilities. Section 3 is a discussion of video and data compression techniques used as well as a mission timeline analysis.

[Evaluating the activity of the Italian Mental Health Services inpatient and residential facilities: the PRISM (Process Indicator System for Mental health) indicators].

PubMed

Picardi, Angelo; Tarolla, Emanuele; de Girolamo, Giovanni; Gigantesco, Antonella; Neri, Giovanni; Rossi, Elisabetta; Biondi, Massimo

2014-01-01

This article describes the activities of a project aimed at developing a system of process and process/outcome indicators suitable to monitor over time the quality of psychiatric care of Italian inpatient and residential psychiatric facilities. This system, named PRISM (Process Indicator System for Mental health), was developed by means of a standardized evaluation made by a panel of experts and a consecutive pilot study in 17 inpatient and 13 residential psychiatric facilities. A total of 28 indicators were selected from a set of 251 candidate indicators developed by the most relevant and qualified Italian and international authorities. These indicators are derived by data from medical records and information about characteristics of facilities, and they cover processes of care, operational equipment of facilities, staff training and working, relationships with external agencies, and sentinel events. The procedure followed for the development of the indicator system was reliable and innovative. The data collected from the pilot study suggested a favourable benefit-cost ratio between the workload associated with regular use of the indicators into the context of daily clinical activities and the advantages related to the information gathered through regular use of the indicators. CONCLUSIONS.:The PRISM system provides additional information about the healthcare processes with respect to the information gathered via routine information systems, and it might prove useful for both continuous quality improvement programs and health services research.

Factors determining the viability of radiation processing in developing countries

NASA Astrophysics Data System (ADS)

van der Linde, HJ; Basson, RA

In the fifteen years since the introduction of radiation processing to South Africa, four commercial irradiation facilities have been established. These are involved in the processing of a large variety of products, from syringes and prostheses to strawberries and sugar yeast. Three of the facilities are devoted mainly to food irradiation and several thousand tonnes are now processed annually. During this period it was repeatedly experienced that the successful introduction of radiation processing in general, and food radurization in particular, on a commercial scale was critically dependent on the following factors: acceptance by the producer, industry and consumer; initial capital expenditure; running costs and overheads in general; and continous throughput. All of these factors contribute to the processing cost which is the ultimate factor in determing the value/price ratio for the potential entrepreneur and customer of this new technology. After a market survey had identified the need for a new food irradiation facility to cope with the growing interest in commercial food radurization in the Western Cape, the above-mentioned factors were of cardinal importance in the design and manufacture of a new irradiator. The resulting batch-pallet facility which was commisioned in August 1986, is rather inefficient as far as energy utilization is concerned but this shortcoming is compensated for by its low cost, versatility and low hold-up. Although the facility has limitations as far as the processing of really large volumes of produce is concerned, it is particularly suitable not only for developing countries, but for developed countries in the introductory phase of commercial food radurization.

Spacelab Data Processing Facility (SLDPF) quality assurance expert systems development

NASA Technical Reports Server (NTRS)

Basile, Lisa R.; Kelly, Angelita C.

1987-01-01

The Spacelab Data Processing Facility (SLDPF) is an integral part of the Space Shuttle data network for missions that involve attached scientific payloads. Expert system prototypes were developed to aid in the performance of the quality assurance function of the Spacelab and/or Attached Shuttle Payloads processed telemetry data. The Spacelab Input Processing System (SIPS) and the Spacelab Output Processing System (SOPS), two expert systems, were developed to determine their feasibility and potential in the quality assurance of processed telemetry data. The capabilities and performance of these systems are discussed.

14 CFR Special Federal Aviation... - Process for Requesting Waiver of Mandatory Separation Age for a Federal Aviation Administration...

Code of Federal Regulations, 2014 CFR

2014-01-01

... Stations, Enroute or Terminal Facilities, and the David J. Hurley Air Traffic Control System Command Center... Stations, Enroute or Terminal Facilities, and the David J. Hurley Air Traffic Control System Command Center..., enroute facilities, terminal facilities, or at the David J. Hurley Air Traffic Control System Command...

14 CFR Special Federal Aviation... - Process for Requesting Waiver of Mandatory Separation Age for a Federal Aviation Administration...

Code of Federal Regulations, 2012 CFR

2012-01-01

... Stations, Enroute or Terminal Facilities, and the David J. Hurley Air Traffic Control System Command Center... Stations, Enroute or Terminal Facilities, and the David J. Hurley Air Traffic Control System Command Center..., enroute facilities, terminal facilities, or at the David J. Hurley Air Traffic Control System Command...