78 FR 54626 - Announcing Approval of Federal Information Processing Standard (FIPS) Publication 201-2, Personal...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-05

... its virtual contact interface be made mandatory as soon as possible for the many beneficial features... messaging and the virtual contact interface in the Standard, some Federal departments and agencies have... Laboratory Programs. [FR Doc. 2013-21491 Filed 9-4-13; 8:45 am] BILLING CODE 3510-13-P ...

What do We Know about Family Interventions for Psychosis at the Process Level? A Systematic Review.

PubMed

Grácio, Jaime; Gonçalves-Pereira, Manuel; Leff, Julian

2016-03-01

The evidence regarding effectiveness of family interventions for psychosis (FIP) is strong and consistent. However, there is a gap in the research on the process of these interventions, and little is known about their active ingredients. This review aims to identify the active ingredients of FIP. We conducted a systematic literature review, focusing on qualitative research, and analyzed 22 papers in total. We found a single study comprehensively exploring the process of FIP. All other studies focused on particular aspects of process-related variables. The key elements of FIP seem to be the so-called "common therapeutic factors", followed by education about the illness and coping skills training. This review supports the value of a stepped model of intervention according to the needs of the families. However, the evidence reviewed also reveals a gap in the research findings based on the limited research available. FIP are complex, psychosocial interventions with multiple components, and more intensive, qualitative research is needed to establish linkages between process and outcome. © 2015 Family Process Institute.

28 CFR 51.28 - Supplemental contents.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Information Processing Standards (FIPS-55) code. (v) Census tracts shall be left justified, and census blocks shall be left justified and blank filled if less than four characters. (vi) Unused plan fields shall be... affected, containing the following information: (1) The prior and new boundaries of the voting unit or...

Do Family Interventions Improve Outcomes in Early Psychosis? A Systematic Review and Meta-Analysis

PubMed Central

Claxton, Melanie; Onwumere, Juliana; Fornells-Ambrojo, Miriam

2017-01-01

Family interventions for psychosis (FIp) are effective in reducing service user relapse and carer distress in people with schizophrenia-spectrum conditions. Several treatment and best practice guidelines recommend FIp for all people with schizophrenia. However, outcome findings in relation to early psychosis groups have been inconsistent. The current paper reports a systematic review and meta-analyses of articles that evaluated FIp in early psychosis with a clearly defined comparison group. A combination of electronic database searches (using PsychINFO, Medline, and CENTRAL), citation searches and hand searches of key journals and reviews was conducted. Peer-reviewed articles published in English from database inception to June 2016 were included. Methodological quality was assessed using the Effective Public Health Practice Project Quality Assessment Tool (EPHPP). Seventeen papers from 14 studies met inclusion criteria for review, the overall quality of which was moderate. Meta-analytic synthesis showed that FIp improved service user functioning and reduced the likelihood of relapse by the end of treatment. Psychotic symptoms were significantly reduced in the FIp group at follow up, but this was not evident at end of treatment. In terms of FIp target mechanisms, carers receiving FIp were more likely to shift from high to low expressed emotion and less likely to report patient focused criticism or engage in conflict communication than carers randomized to standard care. Carer burden and well-being were improved by the end of treatment but gains were not sustained at follow up. FIp had no impact on carer emotional over-involvement. The findings indicate that FIp is an effective intervention for early psychosis service users and their relatives. However, further research is required to establish which key therapeutic components of FIp are most effective for whom, in addition to understanding the mechanisms by which FIp might affect positive change. PMID:28396643

77 FR 40338 - Announcing Revised Draft Federal Information Processing Standard (FIPS) 201-2, Personal Identity...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-09

... may be sent to: Chief, Computer Security Division, Information Technology Laboratory, ATTN: Comments... introduces the concept of a virtual contact interface, over which all functionality of the PIV Card is... Laboratory Programs. [FR Doc. 2012-16725 Filed 7-6-12; 8:45 am] BILLING CODE 3510-13-P ...

Performances of different diagnostic tests for feline infectious peritonitis in challenging clinical cases.

PubMed

Giori, L; Giordano, A; Giudice, C; Grieco, V; Paltrinieri, S

2011-03-01

Feline infectious peritonitis (FIP) can be difficult to diagnose. Histopathology is considered the gold standard test but immunohistochemistry (IHC) is mandatory to confirm/exclude the disease. This study aimed to assess the performances of tests carried out in vivo or at postmortem examination in challenging cases in which FIP was confirmed or excluded based on IHC or on adequate follow-up. Twelve cases (four without FIP, eight with FIP) were retrospectively studied. Clinical findings, serum protein electrophoresis (SPE), analysis of the effusions (AE), antifeline coronavirus serology, serum concentration of α1-acid glycoprotein (AGP) and histopathology were classified as consistent, doubtful or non-consistent with FIP. Sensitivity, specificity and concordance (κ) with the final diagnosis were calculated. Concordance was absent for serology (κ=-0·08) and AE (κ=-0·52), poor for histopathology (κ=0·09), fair for SPE (κ=0·25) and perfect for AGP (κ=1·00). Sensitivity was high for AGP (100%) and low for AE (50%), SPE (37·5%) and histopathology (37·5%). Specificity was high for AGP or histopathology (100%) and low for SPE (50%) and AE (0%). IHC must always be performed to confirm FIP. If this is not possible, when histopathology is controversial, elevated AGP concentrations may support the diagnosis of FIP. © 2011 British Small Animal Veterinary Association.

Raster profile development for the spatial data transfer standard

USGS Publications Warehouse

Szemraj, John A.

1993-01-01

The Spatial Data Transfer Standard (SDTS), recently approved as Federal Information Processing Standard (FIPS) Publication 173, is designed to transfer various types of spatial data. Implementing all of the standard's options at one time is impractical. Profiles, or limited subsets of the SDTS, are the mechanisms by which the standards will be implemented. The development of a raster profile is being coordinated by the U.S. Geological Survey's (USGS) SDTS Task Force. This raster profile is intended to accommodate digital georeferenced image data and regularly spaces, georeferenced gridded data. The USGS's digital elevation models (DEMs) and digital orthophoto quadrangles (DOQs), National Oceanic and Atmospheric Administration's (NOAA) advanced very huh resolution radiometer (AVHRR) and Landsat data, and National Aeronautics and Space Administration's (NASA) Earth observing system (EOS) data are among the candidate data sets for this profile. Other raster profiles, designed to support nongeoreferenced and other types of "raw" sensor data will be consider in the future. As with the Topological Vector Profile (TVP) for the SDTS, development of the raster profile includes designing a prototype profile, testing the prototype profile using sample data sets, and finally, requesting and receiving FIPS approval.

FipsOrtho: A Spell Checker for Learners of French

ERIC Educational Resources Information Center

L'Haire, Sebastien

2007-01-01

This paper presents FipsOrtho, a spell checker targeted at learners of French, and a corpus of learners' errors which has been gathered to test the system and to get a sample of specific language learners' errors. Spell checkers are a standard feature of many software products, however they are not designed for specific language learners' errors.…

An Analysis of the General Services Administration Board of Contract Appeals Bid Protest Decisions and the Effect on Automated Data Processing Equipment/Federal Information Processing Resources Procurements

DTIC Science & Technology

1991-12-01

associated with ADP/FIP protests. Navy and Marine Corps contracting agencies w\\ere contacted to determine their current experience in ADP/’FIP contracting...an emphasis on the GSBCA. A protestor has many options in vhich to "avenge" their wrong. A Contracting Officer can therefore expect a variety of...subject to their exclusive procurement authority. The term ADPE and ADP/FIP will be used somewhat loosely. In most cases, the acronyms include

Fip1 regulates mRNA alternative polyadenylation to promote stem cell self-renewal

PubMed Central

Lackford, Brad; Yao, Chengguo; Charles, Georgette M; Weng, Lingjie; Zheng, Xiaofeng; Choi, Eun-A; Xie, Xiaohui; Wan, Ji; Xing, Yi; Freudenberg, Johannes M; Yang, Pengyi; Jothi, Raja; Hu, Guang; Shi, Yongsheng

2014-01-01

mRNA alternative polyadenylation (APA) plays a critical role in post-transcriptional gene control and is highly regulated during development and disease. However, the regulatory mechanisms and functional consequences of APA remain poorly understood. Here, we show that an mRNA 3′ processing factor, Fip1, is essential for embryonic stem cell (ESC) self-renewal and somatic cell reprogramming. Fip1 promotes stem cell maintenance, in part, by activating the ESC-specific APA profiles to ensure the optimal expression of a specific set of genes, including critical self-renewal factors. Fip1 expression and the Fip1-dependent APA program change during ESC differentiation and are restored to an ESC-like state during somatic reprogramming. Mechanistically, we provide evidence that the specificity of Fip1-mediated APA regulation depends on multiple factors, including Fip1-RNA interactions and the distance between APA sites. Together, our data highlight the role for post-transcriptional control in stem cell self-renewal, provide mechanistic insight on APA regulation in development, and establish an important function for APA in cell fate specification. PMID:24596251

Creating an Assured Joint DOD and Interagency Interoperable Net-Centric Enterprise. Report of the Defense Science Board Task Force on Achieving Interoperability in a Net-Centric Environment

DTIC Science & Technology

2009-03-01

policy, elliptic curve public key cryptography using the 256 -bit prime modulus elliptic curve as specified in FIPS-186-2 and SHA - 256 are appropriate for...publications/fips/fips186-2/fips186-2-change1.pdf 76 I P ART I . CH A PT E R 5 Hashing via the Secure Hash Algorithm (using SHA - 256 and...lithography and processing techniques. Field programmable gate arrays ( FPGAs ) are a chip design of interest. These devices are extensively used in

Diffusion in the chromosphere and the composition of the solar corona and energetic particles

NASA Technical Reports Server (NTRS)

Vauclair, S.; Meyer, J. P.

1985-01-01

Composition observations, in the solar photosphere, and in the upper transition region (TR) and corona imply a change of composition of the solar atmosphere somewhere between the photosphere and the upper TR. Heavy elements with first ionization potential (FIP) 9 eV (high-FIP element) are approx. 4 times less abundant in the TR and corona than in the photosphere, as compared to both hydrogen and heavy elements with lower low-FIP elements. A separation is suggested between neutral and ionized elements in a region where the high-FIP elements are mostly neutral, and the low-FIP elements ionized. This occurs in the chromosphere at altitudes above 600 km and below 2000 km above Photosphere. Whether the diffusion processes can explain the observed change in composition is investigated.

FIP BIAS EVOLUTION IN A DECAYING ACTIVE REGION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baker, D.; Yardley, S. L.; Driel-Gesztelyi, L. van

Solar coronal plasma composition is typically characterized by first ionization potential (FIP) bias. Using spectra obtained by Hinode’s EUV Imaging Spectrometer instrument, we present a series of large-scale, spatially resolved composition maps of active region (AR)11389. The composition maps show how FIP bias evolves within the decaying AR during the period 2012 January 4–6. Globally, FIP bias decreases throughout the AR. We analyzed areas of significant plasma composition changes within the decaying AR and found that small-scale evolution in the photospheric magnetic field is closely linked to the FIP bias evolution observed in the corona. During the AR’s decay phase,more » small bipoles emerging within supergranular cells reconnect with the pre-existing AR field, creating a pathway along which photospheric and coronal plasmas can mix. The mixing timescales are shorter than those of plasma enrichment processes. Eruptive activity also results in shifting the FIP bias closer to photospheric in the affected areas. Finally, the FIP bias still remains dominantly coronal only in a part of the AR’s high-flux density core. We conclude that in the decay phase of an AR’s lifetime, the FIP bias is becoming increasingly modulated by episodes of small-scale flux emergence, i.e., decreasing the AR’s overall FIP bias. Our results show that magnetic field evolution plays an important role in compositional changes during AR development, revealing a more complex relationship than expected from previous well-known Skylab results showing that FIP bias increases almost linearly with age in young ARs.« less

Abundance ratios of oxygen, neon, and magnesium in solar active regions and flares: The FIP effect

NASA Technical Reports Server (NTRS)

Widing, K. G.; Feldman, U.

1995-01-01

Relative abundances of oxygen, neon, and magnesium have been derived for a sample of nine solar active regions, flares, and an erupting prominance by combining plots of the ion differential emission measures. The observations were photographed in the 300-600 A range by the Naval Research Laboratory (NRL) spectroheliograph on Skylab. Methods for deriving the Mg/Ne abundance ratio-which measures the separation between the low- first ionization potential (FIP) and high-FIP abundnace plateaus-have been described in previous papers. In this paper we describe the spectroscopic methods for deriving the O/Ne abundance ratio, which gives the ratio between two high-FIP elements. The plot of the O/Ne ratio versus the Mg/Ne ratio in the sample of nine Skylab events is shown. The variation in the Mg/Ne ratio by a factor of 6 is associated with a much smaller range in the O/Ne ratio. This is broadly consistent with the presence of the standard FIP pattern of abundances in the outer atmosphere of the Sun. However, a real change in the relative abundances of oxygen and neon by a factor of 1.5 cannot be excluded.

Composition of Coronal Mass Ejections

NASA Technical Reports Server (NTRS)

Zurbuchen, T. H.; Weberg, M.; von Steiger, R.; Mewaldt, R. A.; Lepri, S. T.; Antiochos, S. K.

2016-01-01

We analyze the physical origin of plasmas that are ejected from the solar corona. To address this issue, we perform a comprehensive analysis of the elemental composition of interplanetary coronal mass ejections (ICMEs) using recently released elemental composition data for Fe, Mg, Si, S, C, N, Ne, and He as compared to O and H. We find that ICMEs exhibit a systematic abundance increase of elements with first ionization potential (FIP) less than 10 electronvolts, as well as a significant increase of Ne as compared to quasi-stationary solar wind. ICME plasmas have a stronger FIP effect than slow wind, which indicates either that an FIP process is active during the ICME ejection or that a different type of solar plasma is injected into ICMEs. The observed FIP fractionation is largest during times when the Fe ionic charge states are elevated above Q (sub Fe) is greater than 12.0. For ICMEs with elevated charge states, the FIP effect is enhanced by 70 percent over that of the slow wind. We argue that the compositionally hot parts of ICMEs are active region loops that do not normally have access to the heliosphere through the processes that give rise to solar wind. We also discuss the implications of this result for solar energetic particles accelerated during solar eruptions and for the origin of the slow wind itself.

Composition of Coronal Mass Ejections

NASA Astrophysics Data System (ADS)

Zurbuchen, T. H.; Weberg, M.; von Steiger, R.; Mewaldt, R. A.; Lepri, S. T.; Antiochos, S. K.

2016-07-01

We analyze the physical origin of plasmas that are ejected from the solar corona. To address this issue, we perform a comprehensive analysis of the elemental composition of interplanetary coronal mass ejections (ICMEs) using recently released elemental composition data for Fe, Mg, Si, S, C, N, Ne, and He as compared to O and H. We find that ICMEs exhibit a systematic abundance increase of elements with first ionization potential (FIP) < 10 eV, as well as a significant increase of Ne as compared to quasi-stationary solar wind. ICME plasmas have a stronger FIP effect than slow wind, which indicates either that an FIP process is active during the ICME ejection or that a different type of solar plasma is injected into ICMEs. The observed FIP fractionation is largest during times when the Fe ionic charge states are elevated above Q Fe > 12.0. For ICMEs with elevated charge states, the FIP effect is enhanced by 70% over that of the slow wind. We argue that the compositionally hot parts of ICMEs are active region loops that do not normally have access to the heliosphere through the processes that give rise to solar wind. We also discuss the implications of this result for solar energetic particles accelerated during solar eruptions and for the origin of the slow wind itself.

Evidence for the in vivo polymerization of ependymin: a brain extracellular glycoprotein.

PubMed

Shashoua, V E; Hesse, G W; Milinazzo, B

1990-07-09

Ependymin, a glycoprotein of the brain extracellular fluid, has been implicated in synaptic changes associated with the consolidation process of long-term memory formation and the activity-dependent sharpening of connections of regenerating optic nerve. In vitro experiments have demonstrated that ependymin has the capacity to form fibrous insoluble polymers (FIP) when the solvent Ca2+ concentration is reduced by the addition of EGTA. Such products, once formed, do not dissolve in 2% sodium dodecyl sulfate (SDS) in 5 M urea. This property was used to develop a method for isolating brain FIP. A reproducible quantity of FIP was found in goldfish and mouse brain. This was highly concentrated in the synaptosomal fraction and had identical immunoreactivity properties to FIP obtained by the polymerization of pure ependymin in vitro as well as a cross-reactivity to other protein components of the extracellular matrix such as fibronectin and laminin. Labeling studies with [35S]methionine showed that labeled FIP aggregates are synthesized in vivo and become associated with the synaptosomal fraction. A comparison of the amino acid sequence of ependymin with those for proteins of the extracellular matrix indicated that common sequences 5-6 amino acids long exist in the molecules. These homologies may explain why antibodies to fibronectin, laminin and tubulin can recognize the FIP prepared from pure ependymin. These results suggest that ependymin can polymerize in vivo to form FIP aggregates which have similar immunoreactivity properties to major components of the brain extracellular matrix.

Bringing it all back home: Understanding the medical difficulties encountered by newly released prisoners in New Orleans, Louisiana - a qualitative study.

PubMed

Vail, William Lee; Niyogi, Anjali; Henderson, Norris; Wennerstrom, Ashley

2017-07-01

Formerly incarcerated persons (FIPs) face a disproportionate risk of death and serious illness in the immediate post-release period. Therefore, it is a critical time to initiate community-based care for chronic illnesses and behavioural disorders. Little is known about the unique transitional health and social support needs of FIPs in Louisiana, which has the highest incarceration rate in the world. As the average age of prisoners in the United States rises, the release of older prisoners with chronic conditions will become increasingly common. The aim of this study was to explore the healthcare experiences of FIPs in Louisiana in order to inform delivery of services tailored to this population. This research was done in partnership with a community organisation that advocates for restoration of voting rights to FIPs and helps newly released individuals transition back into society. This organisation identified FIPs in the Greater New Orleans area, and from January to May 2015, we conducted 24 semi-structured, in-person, audio-recorded interviews at the community organisation's transitional living facility. The interviews assessed FIPs' experiences with and barriers to receiving healthcare during and after incarceration. These discussions also explored FIPs' desires for services and attitudes towards health and healthcare. Interviews were transcribed and independently coded by two researchers. Interviewees reported negative experiences with healthcare during incarceration, and limited health guidance during the pre-release process. Post-release concerns included lack of insurance, difficulty accessing care and medication, and interest in learning about healthy lifestyles. Results suggest a need for a formalised system of transitional healthcare for FIPs. Findings are being used to inform a pilot transitional care clinic in New Orleans, Louisiana. © 2017 John Wiley & Sons Ltd.

The Rab11 Effector Protein FIP1 Regulates Adiponectin Trafficking and Secretion

PubMed Central

Moreno-Navarrete, Jose Maria; Fernandez-Real, Jose Manuel; Mora, Silvia

2013-01-01

Adiponectin is an adipokine secreted by white adipocytes involved in regulating insulin sensitivity in peripheral tissues. Secretion of adiponectin in adipocytes relies on the endosomal system, however, the intracellular machinery involved in mediating adiponectin release is unknown. We have previously reported that intracellular adiponectin partially compartmentalizes with rab 5 and rab11, markers for the early/sorting and recycling compartments respectively. Here we have examined the role of several rab11 downstream effector proteins (rab11 FIPs) in regulating adiponectin trafficking and secretion. Overexpression of wild type rab11 FIP1, FIP3 and FIP5 decreased the amount of secreted adiponectin expressed in HEK293 cells, whereas overexpression of rab11 FIP2 or FIP4 had no effect. Furthermore shRNA-mediated depletion of FIP1 enhanced adiponectin release whereas knock down of FIP5 decreased adiponectin secretion. Knock down of FIP3 had no effect. In 3T3L1 adipocytes, endogenous FIP1 co-distributed intracellularly with endogenous adiponectin and FIP1 depletion enhanced adiponectin release without altering insulin-mediated trafficking of the glucose transporter Glut4. While adiponectin receptors internalized with transferrin receptors, there were no differences in transferrin receptor recycling between wild type and FIP1 depleted adipocytes. Consistent with its inhibitory role, FIP1 expression was decreased during adipocyte differentiation, by treatment with thiazolidinediones, and with increased BMI in humans. In contrast, FIP1 expression increased upon exposure of adipocytes to TNFα. In all, our findings identify FIP1 as a novel protein involved in the regulation of adiponectin trafficking and release. PMID:24040321

Measuring Elemental Abundances in Impulsive Heating Events with EIS

NASA Astrophysics Data System (ADS)

Warren, Harry; Doschek, George A.; Young, Peter

2015-04-01

It is well established that elemental abundances vary in the solar atmosphere and that this variation is organized by first ionization potential (FIP). Previous studies have indicated that in the solar corona low FIP elements, such as Fe, Si, and Mg, are enriched relative to high FIP elements, such as H, He, C, N, and O. In this paper we report on measurements of plasma composition made during transient heating events observed at transition region temperatures with the Extreme Ultraviolet Imaging Spectrometer (EIS) on Hinode. During these events the intensities of O IV, V, and VI emission lines are enhanced relative to emission lines from Mg V, VI, and VII and indicate a composition close to that of the photosphere. Differential emission measure calculations show a broad distribution of temperatures in these events. Long-lived coronal structures, in contrast, show an enrichment of low FIP elements and relatively narrow temperature distributions. We conjecture that plasma composition is an important signature of the coronal heating process, with impulsive heating leading to the evaporation of unfractionated material from the lower layers of the solar atmosphere and higher frequency heating leading to the accumulation of low-FIP elements in the corona.

Transition Region Abundance Measurements During Impulsive Heating Events

NASA Astrophysics Data System (ADS)

Warren, Harry P.; Brooks, David H.; Doschek, George A.; Feldman, Uri

2016-06-01

It is well established that elemental abundances vary in the solar atmosphere and that this variation is organized by first ionization potential (FIP). Previous studies have shown that in the solar corona, low-FIP elements such as Fe, Si, Mg, and Ca, are generally enriched relative to high-FIP elements such as C, N, O, Ar, and Ne. In this paper we report on measurements of plasma composition made during impulsive heating events observed at transition region temperatures with the Extreme Ultraviolet Imaging Spectrometer (EIS) on Hinode. During these events the intensities of O IV, v, and VI emission lines are enhanced relative to emission lines from Mg v, VI, and vii and Si VI and vii, and indicate a composition close to that of the photosphere. Long-lived coronal fan structures, in contrast, show an enrichment of low-FIP elements. We conjecture that the plasma composition is an important signature of the coronal heating process, with impulsive heating leading to the evaporation of unfractionated material from the lower layers of the solar atmosphere and higher-frequency heating leading to long-lived structures and the accumulation of low-FIP elements in the corona.

Government Open Systems Interconnection Profile (GOSIP) transition strategy

NASA Astrophysics Data System (ADS)

Laxen, Mark R.

1993-09-01

This thesis analyzes the Government Open Systems Interconnection Profile (GOSIP) and the requirements of the Federal Information Processing Standard (FIPS) Publication 146-1. It begins by examining the International Organization for Standardization (ISO) Open Systems Interconnection (OSI) architecture and protocol suites and the distinctions between GOSIP version one and two. Additionally, it explores some of the GOSIP protocol details and discusses the process by which standards organizations have developed their recommendations. Implementation considerations from both government and vendor perspectives illustrate the barriers and requirements faced by information systems managers, as well as basic transition strategies. The result of this thesis is to show a transition strategy through an extended and coordinated period of coexistence due to extensive legacy systems and GOSIP product unavailability. Recommendations for GOSIP protocol standards to include capabilities outside the OSI model are also presented.

Heterologous expression of the immunomodulatory protein gene from Ganoderma sinense in the basidiomycete Coprinopsis cinerea.

PubMed

Han, F; Liu, Y; Guo, L Q; Zeng, X L; Liu, Z M; Lin, J F

2010-11-01

FIP-gsi, a fungal immunomodulatory protein found in Ganoderma sinense, has antitumour, anti-allergy and immunomodulatory activities and is regulated by the fip-gsi gene. In this study, we aimed to express the fip-gsi gene from G. sinense in Coprinopsis cinerea to increase yield of FIPs-gsi. A fungal expression vector pBfip-gsi containing the gpd promoter from Agaricus bisporus and the fip-gsi gene from the G. sinense was constructed and transformed into C. cinerea. PCR and Southern blotting analysis verified the successful integration of the exogenous gene fip-gsi into the genome of C. cinerea. RT-PCR and Northern blotting analysis confirmed that the fip-gsi gene was transcribed in C. cinerea. The yield of the FIP-gsi protein reached 314mg kg(-1) fresh mycelia. The molecular weight of the FIP-gsi was 13kDa, and the FIP-gsi was capable of hemagglutinating mouse red blood cells, but no such activity was observed towards human red blood cells in vitro. The fip-gsi from G. sinense has been successfully translated in C. cinerea, and the yield of bioactive FIP-gsi protein was high. This is the first report using the C. cinerea for the heterologous expression of FIP-gsi protein and it might supply a basis for large-scale production of the protein. © 2010 The Authors. Journal of Applied Microbiology © 2010 The Society for Applied Microbiology.

Fisher-Level Decision Making to Participate in Fisheries Improvement Projects (FIPs) for Yellowfin Tuna in the Philippines

PubMed Central

Berentsen, Paul; Bush, Simon R.; Digal, Larry; Oude Lansink, Alfons

2016-01-01

This study identifies the capabilities needed by small-scale fishers to participate in Fishery Improvement Projects (FIPs) for yellowfin tuna in the Philippines. The current literature provides little empirical evidence on how different models, or types of FIPs, influence the participation of fishers in their programs and the degree which FIPs are able to foster improvements in fishing practices. To address this literature gap, two different FIPs are empirically analysed, each with different approaches for fostering improvement. The first is the non-governmental organisation-led Partnership Programme Towards Sustainable Tuna, which adopts a bottom-up or development oriented FIP model. The second is the private-led Artesmar FIP, which adopts a top-down or market-oriented FIP approach. The data were obtained from 350 fishers surveyed and were analysed using two separate models run in succession, taking into consideration full, partial, and non-participation in the two FIPs. The results demonstrate that different types of capabilities are required in order to participate in different FIP models. Individual firm capabilities are more important for fishers participation in market-oriented FIPs, which use direct economic incentives to encourage improvements in fisher practices. Collective capabilities are more important for fishers to participate in development-oriented FIPs, which drive improvement by supporting fishers, fisher associations, and governments to move towards market requirements. PMID:27732607

Fisher-Level Decision Making to Participate in Fisheries Improvement Projects (FIPs) for Yellowfin Tuna in the Philippines.

PubMed

Tolentino-Zondervan, Frazen; Berentsen, Paul; Bush, Simon R; Digal, Larry; Oude Lansink, Alfons

2016-01-01

This study identifies the capabilities needed by small-scale fishers to participate in Fishery Improvement Projects (FIPs) for yellowfin tuna in the Philippines. The current literature provides little empirical evidence on how different models, or types of FIPs, influence the participation of fishers in their programs and the degree which FIPs are able to foster improvements in fishing practices. To address this literature gap, two different FIPs are empirically analysed, each with different approaches for fostering improvement. The first is the non-governmental organisation-led Partnership Programme Towards Sustainable Tuna, which adopts a bottom-up or development oriented FIP model. The second is the private-led Artesmar FIP, which adopts a top-down or market-oriented FIP approach. The data were obtained from 350 fishers surveyed and were analysed using two separate models run in succession, taking into consideration full, partial, and non-participation in the two FIPs. The results demonstrate that different types of capabilities are required in order to participate in different FIP models. Individual firm capabilities are more important for fishers participation in market-oriented FIPs, which use direct economic incentives to encourage improvements in fisher practices. Collective capabilities are more important for fishers to participate in development-oriented FIPs, which drive improvement by supporting fishers, fisher associations, and governments to move towards market requirements.

A snoRNA modulates mRNA 3′ end processing and regulates the expression of a subset of mRNAs

PubMed Central

Huang, Chunliu; Shi, Junjie; Guo, Yibin; Huang, Weijun; Huang, Shanshan; Ming, Siqi; Wu, Xingui; Zhang, Rui; Ding, Junjun; Zhao, Wei; Jia, Jie; Huang, Xi; Xiang, Andy Peng

2017-01-01

Abstract mRNA 3′ end processing is an essential step in gene expression. It is well established that canonical eukaryotic pre-mRNA 3′ processing is carried out within a macromolecular machinery consisting of dozens of trans-acting proteins. However, it is unknown whether RNAs play any role in this process. Unexpectedly, we found that a subset of small nucleolar RNAs (snoRNAs) are associated with the mammalian mRNA 3′ processing complex. These snoRNAs primarily interact with Fip1, a component of cleavage and polyadenylation specificity factor (CPSF). We have functionally characterized one of these snoRNAs and our results demonstrated that the U/A-rich SNORD50A inhibits mRNA 3′ processing by blocking the Fip1-poly(A) site (PAS) interaction. Consistently, SNORD50A depletion altered the Fip1–RNA interaction landscape and changed the alternative polyadenylation (APA) profiles and/or transcript levels of a subset of genes. Taken together, our data revealed a novel function for snoRNAs and provided the first evidence that non-coding RNAs may play an important role in regulating mRNA 3′ processing. PMID:28911119

The Coronal Abundance Anomalies of M Dwarfs

NASA Astrophysics Data System (ADS)

Wood, Brian E.; Laming, J. Martin; Karovska, Margarita

2012-07-01

We analyze Chandra X-ray spectra of the M0 V+M0 V binary GJ 338. As quantified by X-ray surface flux, these are the most inactive M dwarfs ever observed with X-ray grating spectroscopy. We focus on measuring coronal abundances, in particular searching for evidence of abundance anomalies related to first ionization potential (FIP). In the solar corona and wind, low-FIP elements are overabundant, which is the so-called FIP effect. For other stars, particularly very active ones, an "inverse FIP effect" is often observed, with low-FIP elements being underabundant. For both members of the GJ 338 binary, we find evidence for a modest inverse FIP effect, consistent with expectations from a previously reported correlation between spectral type and FIP bias. This amounts to strong evidence that all M dwarfs should exhibit the inverse FIP effect phenomenon, not just the active ones. We take the first step toward modeling the inverse FIP phenomenon in M dwarfs, building on past work that has demonstrated that MHD waves coursing through coronal loops can lead to a ponderomotive force that fractionates elements in a manner consistent with the FIP effect. We demonstrate that in certain circumstances this model can also lead to an inverse FIP effect, pointing the way to more detailed modeling of M dwarf coronal abundances in the future.

40 CFR Appendix A to Subpart A of... - Tables

Code of Federal Regulations, 2010 CFR

2010-07-01

... phone number ✓ ✓ (6) FIPS code ✓ ✓ (7) Facility ID codes ✓ ✓ (8) Unit ID code ✓ ✓ (9) Process ID code... for Reporting on Emissions From Nonpoint Sources and Nonroad Mobile Sources, Where Required by 40 CFR... start date ✓ ✓ (3) Inventory end date ✓ ✓ (4) Contact name ✓ ✓ (5) Contact phone number ✓ ✓ (6) FIPS...

MARK2/EMK1/Par-1Balpha phosphorylation of Rab11-family interacting protein 2 is necessary for the timely establishment of polarity in Madin-Darby canine kidney cells.

PubMed

Ducharme, Nicole A; Hales, Chadwick M; Lapierre, Lynne A; Ham, Amy-Joan L; Oztan, Asli; Apodaca, Gerard; Goldenring, James R

2006-08-01

Rab11a, myosin Vb, and the Rab11-family interacting protein 2 (FIP2) regulate plasma membrane recycling in epithelial cells. This study sought to characterize more fully Rab11-FIP2 function by identifying kinase activities modifying Rab11-FIP2. We have found that gastric microsomal membrane extracts phosphorylate Rab11-FIP2 on serine 227. We identified the kinase that phosphorylated Rab11-FIP2 as MARK2/EMK1/Par-1Balpha (MARK2), and recombinant MARK2 phosphorylated Rab11-FIP2 only on serine 227. We created stable Madin-Darby canine kidney (MDCK) cell lines expressing enhanced green fluorescent protein-Rab11-FIP2 wild type or a nonphosphorylatable mutant [Rab11-FIP2(S227A)]. Analysis of these cell lines demonstrates a new role for Rab11-FIP2 in addition to that in the plasma membrane recycling system. In calcium switch assays, cells expressing Rab11-FIP2(S227A) showed a defect in the timely reestablishment of p120-containing junctional complexes. However, Rab11-FIP2(S227A) did not affect localization with recycling system components or the normal function of apical recycling and transcytosis pathways. These results indicate that phosphorylation of Rab11-FIP2 on serine 227 by MARK2 regulates an alternative pathway modulating the establishment of epithelial polarity.

76 FR 79609 - Federal Acquisition Regulation; Clarification of Standards for Computer Generation of Forms

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-22

... Regulation; Clarification of Standards for Computer Generation of Forms AGENCY: Department of Defense (DoD... American National Standards Institute X12, as the valid standard to use for computer-generated forms. FAR... optional forms on their computers. In addition to clarifying that FIPS 161 is no longer in use, public...

77 FR 11063 - Privacy Act of 1974, System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-24

... provided through the use of internal standard operating procedures in accordance with the FIPS- 201, and NIST 800-53 standards. Retention and disposal: Records are retained using the appropriate, approved... Drive, 11th Floor, Arlington, VA 22202. Notification procedures: Individuals requesting notification of...

Ferrous iron phosphorus in sediments: development of a quantification method through 2,2'-bipyridine extraction.

PubMed

Li, Qingman; Wang, Xingxiang; Bartlett, Rebecca; Pinay, Gilles; Kan, Dan; Zhang, Wen; Sun, Jingxian

2012-11-01

The role of ferrous iron in the phosphorus cycle of an aquatic ecosystem is poorly understood because of a lack of suitable methods to quantitatively evaluate ferrous iron phosphorus (FIP) phases. Using sediments sampled from Fubao Bay of Dianchi Lake in China, a novel extraction method for FIP using 2,2'-bipyridine was explored. Total phosphorus and iron in the sediments ranged from 1.0 to 5.0 mg/g (dry weight) and 28.5 to 90.6 mg/g, respectively. Organic content (as indicated by loss on ignition or LOI) and iron(II) ranged from 3.1 to 27.0% and 26.5 to 64.9 mg/g, respectively. The dissolution dynamics of FIP extraction with a low solid/liquid ratio (1:25) indicated that a single application of 0.2% 2,2'-bipyridine extracted both iron(II) (Fe(II)) and phosphorus (as PO4(3-)) in sediments with different organic contents with low efficiency. The extraction efficiency of Fe(II) was improved by alteration of the solid/liquid ratio, but the effect was limited. However, addition of a 1:1000 solid/liquid ratio of 0.5 M potassium chloride to a 0.2% 2,2'-bipyridine solution significantly accelerated extraction of FIP with the release of Fe(II) and phosphorus toward equilibrium at approximately 150 hours. Further investigation demonstrated that 2,2'-bipyridine exhibited a higher selectivity in distinguishing FIP from phosphorus bound to ferric (Fe(III)) oxides or precipitated by calcium (Ca2+). Air-drying sediments significantly decreased the amount of extracted FIP, which indicates that fresh, wet sediment should be used in this type of FIP extraction. Based on experimental results using the proposed extraction protocol, (1) FIP in sediments of Fubao Bay had a predominant status in the lake sediment and accounted for 23.4 to 39.8% of total phosphorus, and (2) Fe(II)(FIP) released in the extraction is directly proportional to phosphorus(FIP) (Fe(II)(FIP) = 2.84 x P(FIP) + 0.0007; R2 = 0.97) with an average molar ratio of Fe(II)(FIP)/P(FIP) of 2.7. This study shows that FIP extraction with 2,2'-bipyridine is a robust method for releasing ferrous iron associated with phosphorus. Further, the high percentage of FIP in total phosphorus (40%) measured in the study site using this extraction method suggests that FIP might have been often underestimated in previous studies.

Thioredoxin is required for filamentous phage assembly.

PubMed Central

Russel, M; Model, P

1985-01-01

Sequence comparisons show that the fip gene product of Escherichia coli, which is required for filamentous phage assembly, is thioredoxin. Thioredoxin serves as a cofactor for reductive processes in many cell types and is a constituent of phage T7 DNA polymerase. The fip-1 mutation makes filamentous phage and T7 growth temperature sensitive in cells that carry it. The lesion lies within a highly conserved thioredoxin active site. Thioredoxin reductase (NADPH), as well as thioredoxin, is required for efficient filamentous phage production. Mutant phages defective in phage gene I are particularly sensitive to perturbations in the fip-thioredoxin system. A speculative model is presented in which thioredoxin reductase, thioredoxin, and the gene I protein interact to drive an engine for filamentous phage assembly. Images PMID:3881756

Overexpression of Rab11-FIP2 in colorectal cancer cells promotes tumor migration and angiogenesis through increasing secretion of PAI-1.

PubMed

Dong, Wenjie; Wu, Xinai

2018-01-01

Rab11 family-interacting protein 2 (Rab11-FIP2) can interact with MYO5B and plays an important role in regulating plasma membrane recycling. However, little is known about the clinical significance of DUSP2 in colorectal cancer (CRC). In this study, we investigated Rab11-FIP2 expression by immunohistochemistry in 125 patients with colorectal cancer. Conditioned media containing all secreted factors was harvested. Chemokine secretion and expression were analyzed by Chemi-array. We found that the expression level of Rab11-FIP2 was significantly increased in colorectal cancer tissues and high expression of Rab11-FIP2 was closely correlated with nodal metastasis in colorectal cancer patients. Rab11-FIP2 overexpression promoted colorectal cancer metastasis in vitro and in vivo. Finally, we demonstrated that Rab11-FIP2 overexpression may contribute to increased secretion of PAI-1 in human colorectal cancer cells. Our findings reveal a novel mechanism underlying the role of Rab11-FIP2 in colorectal cancer dissemination, suggesting that targeting Rab11-FIP2 might be a promising therapeutic strategy for CRC.

Polyprenyl Immunostimulant Treatment of Cats with Presumptive Non-Effusive Feline Infectious Peritonitis In a Field Study

PubMed Central

Legendre, Alfred M.; Kuritz, Tanya; Galyon, Gina; Baylor, Vivian M.; Heidel, Robert Eric

2017-01-01

Feline infectious peritonitis (FIP) is a fatal disease with no clinically effective treatment. This field study evaluated treatment with Polyprenyl Immunostimulant (PI) in cats with the non-effusive form of FIP. Because immune suppression is a major component in the pathology of FIP, we hypothesized that treatment with an immune system stimulant would increase survival times of cats with dry FIP. Sixty cats, diagnosed with dry FIP by primary care and specialist veterinarians and meeting the acceptance criteria, were treated with PI without intentional selection of less severe cases. The survival time from the start of PI treatment in cats diagnosed with dry FIP showed that of the 60 cats with dry FIP treated with PI, 8 survived over 200 days, and 4 of 60 survived over 300 days. A literature search identified 59 cats with non-effusive or dry FIP; no cat with only dry FIP lived longer than 200 days. Veterinarians of cats treated with PI that survived over 30 days reported improvements in clinical signs and behavior. The survival times in our study were significantly longer in cats who were not treated with corticosteroids concurrently with PI. While not a cure, PI shows promise in the treatment of dry form FIP, but a controlled study will be needed to verify the benefit. PMID:28261584

Detection of feline coronavirus using microcantilever sensors

NASA Astrophysics Data System (ADS)

Velanki, Sreepriya; Ji, Hai-Feng

2006-11-01

This work demonstrated the feasibility of detecting severe acute respiratory syndrome associated coronavirus (SARS-CoV) using microcantilever technology by showing that the feline coronavirus (FIP) type I virus can be detected by a microcantilever modified by feline coronavirus (FIP) type I anti-viral antiserum. A microcantilever modified by FIP type I anti-viral antiserum was developed for the detection of FIP type I virus. When the FIP type I virus positive sample is injected into the fluid cell where the microcantilever is held, the microcantilever bends upon the recognition of the FIP type I virus by the antiserum on the surface of the microcantilever. A negative control sample that does not contain FIP type I virus did not cause any bending of the microcantilever. The detection limit of the sensor was 0.1 µg ml-1 when the assay time was <1 h.

Coronal Diagnostics of Intermediate Activity Star XI Boo A

NASA Technical Reports Server (NTRS)

Drake, Jeremy

2005-01-01

The analysis of Xi Boo A proved difficult to adapt to our line-by-line approach because of the strong wings of the RGS instrumental profile, as has been detailed in earlier reports. While progress was also delayed because of problems in using SAS v4, we succeeded in the past year or so to bring the analysis to conclusion. Abundances have been derived using both EPIC and RGS data, confirming earlier EUVE findings of a mild solar-like FIP effect, though with some evidence of a turn-up in abundances of elements with higher FIP. Plasma densities appear normal for a moderately active stellar corona. Xi Boo A nicely bridges the gap between the very active stars and stars like the Sun, and it indeed does appear that these are the stars in which the solar-like FIP effects begins to change to the "inverse FIP" type of effect seen in the very active stars. Probing this divide was the main goal of the proposal. These results are in the process of being prepared for publication, though we have not decided the target journal as yet.

Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase.

PubMed

Kaufmann, Isabelle; Martin, Georges; Friedlein, Arno; Langen, Hanno; Keller, Walter

2004-02-11

In mammals, polyadenylation of mRNA precursors (pre-mRNAs) by poly(A) polymerase (PAP) depends on cleavage and polyadenylation specificity factor (CPSF). CPSF is a multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal. Based on sequence similarity to the Saccharomyces cerevisiae polyadenylation factor Fip1p, we have identified human Fip1 (hFip1) and found that the protein is an integral subunit of CPSF. hFip1 interacts with PAP and has an arginine-rich RNA-binding motif that preferentially binds to U-rich sequence elements on the pre-mRNA. Recombinant hFip1 is sufficient to stimulate the in vitro polyadenylation activity of PAP in a U-rich element-dependent manner. hFip1, CPSF160 and PAP form a ternary complex in vitro, suggesting that hFip1 and CPSF160 act together in poly(A) site recognition and in cooperative recruitment of PAP to the RNA. These results show that hFip1 significantly contributes to CPSF-mediated stimulation of PAP activity.

Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase

PubMed Central

Kaufmann, Isabelle; Martin, Georges; Friedlein, Arno; Langen, Hanno; Keller, Walter

2004-01-01

In mammals, polyadenylation of mRNA precursors (pre-mRNAs) by poly(A) polymerase (PAP) depends on cleavage and polyadenylation specificity factor (CPSF). CPSF is a multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal. Based on sequence similarity to the Saccharomyces cerevisiae polyadenylation factor Fip1p, we have identified human Fip1 (hFip1) and found that the protein is an integral subunit of CPSF. hFip1 interacts with PAP and has an arginine-rich RNA-binding motif that preferentially binds to U-rich sequence elements on the pre-mRNA. Recombinant hFip1 is sufficient to stimulate the in vitro polyadenylation activity of PAP in a U-rich element-dependent manner. hFip1, CPSF160 and PAP form a ternary complex in vitro, suggesting that hFip1 and CPSF160 act together in poly(A) site recognition and in cooperative recruitment of PAP to the RNA. These results show that hFip1 significantly contributes to CPSF-mediated stimulation of PAP activity. PMID:14749727

Perioperative Bromelain Therapy after Wisdom Teeth Extraction - A Randomized, Placebo-Controlled, Double-Blinded, Three-Armed, Cross-Over Dose-Finding Study.

PubMed

Bormann, Kai-Hendrik; Weber, Kristina; Kloppenburg, Heike; Staude, Pia; Koch, Armin; Meiser, Peter; Gellrich, Nils-Claudius

2016-12-01

Reduction in postoperative edema and inflammatory reactions is the key to the posttraumatic regeneration process. Use of bromelain is well established in this indication, but there is some controversy with regard to the optimal dosing of this drug. The aim of our study was therefore to investigate the efficacy of dosage-dependent therapy with bromelain in patients after wisdom teeth extraction by comparing the registered dosage 1000 FIP (Fédération Internationale Pharmaceutique) against higher dosages of 3000 FIP and 4500 FIP. A total of 75 patients were randomized to one of the three dosage arms, and 68 of these patients were finally analyzed in the modified intention-to-treat population. Patients involved underwent two surgery sessions: one study period being conducted under treatment with bromelain and the other with placebo. Postoperative swelling determined by a 3D face scanning system was defined as the primary endpoint; further efficacy parameters were maximum swelling, pain, difficulty in swallowing, and use of analgesics. A superiority of treatment with 3000 FIP and 4500 FIP versus 1000 FIP could not be demonstrated. The analysis of pooled bromelain treatments versus placebo did, however, show a clear trend in favor of bromelain for all assessments. Adverse events did not occur more frequently under bromelain therapy compared with placebo. This study thus clearly supports the clinical relevance of treatment of postoperative conditions with bromelain, and the recommended daily dose was sufficiently effective in this trial and indication. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

48 CFR 11.102 - Standardization program.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Standardization Manual, FSPM-0001; for DoD components, DoD 4120.24-M, Defense Standardization Program Policies and... (see address in 11.201(d)(1)). DoD 4120.24-M may be obtained from DoD (see 11.201(d)(2) or 11.201(d)(3)). FIPS PUBS may be obtained from the Government Printing Office (GPO), or the Department of Commerce's...

Rab11-family of interacting protein 2 associates with chlamydial inclusions through its Rab-binding domain and promotes bacterial multiplication.

PubMed

Leiva, Natalia; Capmany, Anahí; Damiani, María Teresa

2013-01-01

Chlamydia trachomatis, an obligate intracellular pathogen, survives within host cells in a special compartment named 'inclusion' and takes advantage of host vesicular transport pathways for its growth and replication. Rab GTPases are key regulatory proteins of intracellular trafficking. Several Rabs, among them Rab11 and Rab14, are implicated in chlamydial development. FIP2, a member of the Rab11-Family of Interacting Proteins, presents at the C-terminus a Rab-binding domain that interacts with both Rab11 and Rab14. In this study, we determined and characterized the recruitment of endogenous and GFP-tagged FIP2 to the chlamydial inclusions. The recruitment of FIP2 is specific since other members of the Rab11-Family of Interacting Proteins do not associate with the chlamydial inclusions. The Rab-binding domain of FIP2 is essential for its association. Our results indicate that FIP2 binds to Rab11 at the chlamydial inclusion membrane through its Rab-binding domain. The presence of FIP2 at the chlamydial inclusion favours the recruitment of Rab14. Furthermore, our results show that FIP2 promotes inclusion development and bacterial replication. In agreement, the silencing of FIP2 decreases the bacterial progeny. C. trachomatis likely recruits FIP2 to hijack host intracellular trafficking to redirect vesicles full of nutrients towards the inclusion. © 2012 Blackwell Publishing Ltd.

Recombinant FIP-gat, a Fungal Immunomodulatory Protein from Ganoderma atrum, Induces Growth Inhibition and Cell Death in Breast Cancer Cells.

PubMed

Xu, Hui; Kong, Ying-Yu; Chen, Xin; Guo, Meng-Yuan; Bai, Xiao-Hui; Lu, Yu-Jia; Li, Wei; Zhou, Xuan-Wei

2016-04-06

FIP-gat, an immunomodulatory protein isolated from Ganoderma atrum, is a new member of the FIP family. Little is known, however, about its expressional properties and antitumor activities. It was availably expressed in Escherichia coli with a total yield of 29.75 mg/L. The migration of recombinant FIP-gat (rFIP-gat) on SDS-PAGE corresponded to the predicted molecular mass, and the band was correctly detected by a specific antibody. To characterize the direct effects of rFIP-gat on MDA-MB-231 breast cancer cells, MDA-MB-231 cells were treated with different concentrations of rFIP-gat in vitro; the results showed that this protein could reduce cell viability dose-dependently with a median inhibitory concentration (IC50) of 9.96 μg/mL and agglutinate the MDA-MB-231 cells at a concentration as low as 5 μg/mL. Furthermore, FIP-gat at a concentration of 10 μg/mL can induce significant growth inhibition and cell death in MDA-MB-231 cells. Notably, FIP-gat treatment triggers significant cell cycle arrest at the G1/S transition and pronounced increase in apoptotic cell population. Molecular assays based on microarray and real-time PCR further revealed the potential mechanisms encompassing growth arrest, apoptosis, and autophagy underlying the phenotypic effects.

Drosophila Fip200 is an essential regulator of autophagy that attenuates both growth and aging.

PubMed

Kim, Myungjin; Park, Hae Li; Park, Hwan-Woo; Ro, Seung-Hyun; Nam, Samuel G; Reed, John M; Guan, Jun-Lin; Lee, Jun Hee

2013-08-01

Autophagy-related 1 (Atg1)/Unc-51-like protein kinases (ULKs) are evolutionarily conserved proteins that play critical physiological roles in controlling autophagy, cell growth and neurodevelopment. RB1-inducible coiled-coil 1 (RB1CC1), also known as PTK2/FAK family-interacting protein of 200 kDa (FIP200) is a recently discovered binding partner of ULK1. Here we isolated the Drosophila RB1CC1/FIP200 homolog (Fip200/CG1347) and showed that it mediates Atg1-induced autophagy as a genetically downstream component in diverse physiological contexts. Fip200 loss-of-function mutants experienced severe mobility loss associated with neuronal autophagy defects and neurodegeneration. The Fip200 mutants were also devoid of both developmental and starvation-induced autophagy in salivary gland and fat body, while having no defects in axonal transport and projection in developing neurons. Interestingly, moderate downregulation of Fip200 accelerated both developmental growth and aging, accompanied by target of rapamycin (Tor) signaling upregulation. These results suggest that Fip200 is a critical downstream component of Atg1 and specifically mediates Atg1's autophagy-, aging- and growth-regulating functions.

Drosophila Fip200 is an essential regulator of autophagy that attenuates both growth and aging

PubMed Central

Kim, Myungjin; Park, Hae Li; Park, Hwan-Woo; Ro, Seung-Hyun; Nam, Samuel G.; Reed, John M.; Guan, Jun-Lin; Lee, Jun Hee

2013-01-01

Autophagy-related 1 (Atg1)/Unc-51-like protein kinases (ULKs) are evolutionarily conserved proteins that play critical physiological roles in controlling autophagy, cell growth and neurodevelopment. RB1-inducible coiled-coil 1 (RB1CC1), also known as PTK2/FAK family-interacting protein of 200 kDa (FIP200) is a recently discovered binding partner of ULK1. Here we isolated the Drosophila RB1CC1/FIP200 homolog (Fip200/CG1347) and showed that it mediates Atg1-induced autophagy as a genetically downstream component in diverse physiological contexts. Fip200 loss-of-function mutants experienced severe mobility loss associated with neuronal autophagy defects and neurodegeneration. The Fip200 mutants were also devoid of both developmental and starvation-induced autophagy in salivary gland and fat body, while having no defects in axonal transport and projection in developing neurons. Interestingly, moderate downregulation of Fip200 accelerated both developmental growth and aging, accompanied by target of rapamycin (Tor) signaling upregulation. These results suggest that Fip200 is a critical downstream component of Atg1 and specifically mediates Atg1’s autophagy-, aging- and growth-regulating functions. PMID:23819996

United Information Services, Inc. , CRAY 1-s/2000, FORTRAN CFT 1. 10. Validation summary report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1983-12-13

This Validation Summary Report (VSR) for the United Information Services, Inc., FORTRAN CFT 1.10 running under the COS Level C12 1.11 provides a consolidated summary of the results obtained from the validation of the subject compiler against the 1978 FORTRAN Standard (X3.9-1978/FIPS PUB 69). The compiler was validated against the Full Level FORTRAN level of FIPS PUB 69. The VSR is made up of several sections showing all the discrepancies found -if any. These include an overview of the validation which lists all categories of discrepancies within X3.9-1978, and a detailed listing of discrepancies together with the tests which failed.

Cray Research, Inc. Cray 1-s, Cray FORTRAN translator CFT) version 1. 11 Bugfix 1. Validation summary report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1983-09-09

This Validation Summary Report (VSR) for the Cray Research, Inc., CRAY FORTRAN Translator (CFT) Version 1.11 Bugfix 1 running under the CRAY Operating System (COS) Version 1.12 provides a consolidated summary of the results obtained from the validation of the subject compiler against the 1978 FORTRAN Standard (X3.9-1978/FIPS PUB 69). The compiler was validated against the Full Level FORTRAN level of FIPS PUB 69. The VSR is made up of several sections showing all the discrepancies found -if any. These include an overview of the validation which lists all categories of discrepancies together with the tests which failed.

DNA as a Target for Anticancer Phen-Imidazole Pd(II) Complexes.

PubMed

Heydari, Maryam; Moghadam, Mahboube Eslami; Tarlani, AliAkbar; Farhangian, Hossein

2017-05-01

Imidazole ring is a known structure in many natural or synthetic drug molecules and its metal complexes can interact with DNA and do the cleavage. Hence, to study the influence of the structure and size of the ligand on biological behavior of metal complexes, two water-soluble Pd(II) complexes of phen and FIP ligands (where phen is 1,10-phenanthroline and FIP is 2-(Furan-2-yl)-1H-Imidazo[4,5-f][1, 10]phenanthroline) with the formula of [Pd(phen)(FIP)](NO 3 ) 2 and [Pd(FIP) 2 ]Cl 2 , that were activated against chronic myelogenous leukemia cell line, K562, were selected. Also, the interaction of these anticancer Pd(II) complexes with highly polymerized calf thymus DNA was extensively studied by means of electronic absorption, fluorescence, and circular dichroism in Tris-buffer. The results showed that the binding was positive cooperation and [Pd(phen)(FIP)](NO 3 ) 2 (K f  = 127 M -1 G = 1.2) exhibited higher binding constant and number of binding sites than [Pd(FIP) 2 ]Cl 2 (K f  = 13 M -1 G = 1.03) upon binding to DNA. The fluorescence data indicates that quenching effect for [Pd(phen)(FIP)](NO 3 ) 2 (K SV  = 58 mM -1 ) was higher than [Pd(FIP) 2 ]Cl 2 (K SV  = 12 mM -1 ). Also, [Pd(FIP) 2 ]Cl 2 interacts with ethidium bromide-DNA, as non-competitive inhibition, and can bind to DNA via groove binding and [Pd(phen)(FIP)](NO 3 ) 2 can intercalate in DNA. These results were confirmed by circular dichroism spectra. Docking data revealed that longer complexes have higher interaction energy and bind to DNA via groove binding. Graphical Abstract Two anticancer Pd(II) complexes of imidazole derivative have been synthesized and interacted with calf thymus DNA. Modes of binding have been studied by electronic absorption, fluorescence, and CD measurements. [Pd(FIP) 2 ]Cl 2 can bind to DNA via groove binding while intercalation mode of binding is observed for [Pd(phen)(FIP)](NO 3 ) 2 .

FIP bias in a sigmoidal active region

NASA Astrophysics Data System (ADS)

Baker, D.; Brooks, D. H.; Démoulin, P.; van Driel-Gesztelyi, Lidia; Green, L. M.; Steed, K.; Carlyle, J.

2014-01-01

We investigate first ionization potential (FIP) bias levels in an anemone active region (AR) - coronal hole (CH) complex using an abundance map derived from Hinode/EIS spectra. The detailed, spatially resolved abundance map has a large field of view covering 359'' × 485''. Plasma with high FIP bias, or coronal abundances, is concentrated at the footpoints of the AR loops whereas the surrounding CH has a low FIP bias, ~1, i.e. photospheric abundances. A channel of low FIP bias is located along the AR's main polarity inversion line containing a filament where ongoing flux cancellation is observed, indicating a bald patch magnetic topology characteristic of a sigmoid/flux rope configuration.

Communication performance analysis and comparison of two patterns for data exchange between nodes in WorldFIP fieldbus network.

PubMed

Liang, Geng; Wang, Hong; Li, Wen; Li, Dazhong

2010-10-01

Data exchange patterns between nodes in WorldFIP fieldbus network are quite important and meaningful in improving the communication performance of WorldFIP network. Based on the basic communication ways supported in WorldFIP protocol, we propose two patterns for implementation of data exchange between peer nodes over WorldFIP network. Effects on communication performance of WorldFIP network in terms of some network parameters, such as number of bytes in user's data and turn-around time, in both the proposed patterns, are analyzed at length when different network speeds are applied. Such effects with the patterns of periodic message transmission using acknowledged and non-acknowledged messages, are also studied. Communication performance in both the proposed patterns are analyzed and compared. Practical applications of the research are presented. Through the study, it can be seen that different data exchange patterns make a great difference in improving communication efficiency with different network parameters, which is quite useful and helpful in the practical design of distributed systems based on WorldFIP network. Copyright © 2010 ISA. Published by Elsevier Ltd. All rights reserved.

Positive immunostaining for feline infectious peritonitis (FIP) in a Sphinx cat with cutaneous lesions and bilateral panuveitis.

PubMed

Bauer, Bianca S; Kerr, Moira E; Sandmeyer, Lynne S; Grahn, Bruce H

2013-07-01

Feline infectious peritonitis (FIP) is a common, fatal, systemic disease of cats. This case report describes the antemortem diagnosis of FIP in a 2-year-old spayed female Sphinx cat that presented with a bilateral panuveitis and multiple papular cutaneous lesions. Histopathologically, the skin lesions were characterized by perivascular infiltrates of macrophages, neutrophils, with fewer plasma cells, mast cells, and small lymphocytes in the mid- to deep dermis. Immunohistochemistry for intracellular feline coronavirus (FeCoV) antigen demonstrated positive staining in dermal macrophages providing an antemortem diagnosis of a moderate, nodular to diffuse, pyogranulomatous perivascular dermatitis due to FIP infection. Obtaining an antemortem diagnosis of FIP can be a challenge and cutaneous lesions are rare in the disease. Recognition and biopsy of any cutaneous lesions in cats with panuveitis and suspected FIP can help establish an antemortem diagnosis of the disease. © 2013 American College of Veterinary Ophthalmologists.

An Evaluation Methodology for the Usability and Security of Cloud-based File Sharing Technologies

DTIC Science & Technology

2012-09-01

FISMA, ISO 27001 , FIPS 140-2, and ISO 270001) indicate a cloud-based service’s compliance with industry standard security controls, management and...Information Assurance IEEE Institute of Electrical and Electronics Engineers IT Information Technology ITS Insider Threat Study ISO International...effectively, efficiently and with satisfaction” (International Organization for Standardization [ ISO ], 1998). Alternately, information security

Why people drink shampoo? Food Imitating Products are fooling brains and endangering consumers for marketing purposes.

PubMed

Basso, Frédéric; Robert-Demontrond, Philippe; Hayek, Maryvonne; Anton, Jean-Luc; Nazarian, Bruno; Roth, Muriel; Oullier, Olivier

2014-01-01

A Food Imitating Product (FIP) is a household cleaner or a personal care product that exhibits food attributes in order to enrich consumption experience. As revealed by many cases worldwide, such a marketing strategy led to unintentional self-poisonings and deaths. FIPs therefore constitute a very serious health and public policy issue. To understand why FIPs are a threat, we first conducted a qualitative analysis on real-life cases of household cleaners and personal care products-related phone calls at a poison control center followed by a behavioral experiment. Unintentional self-poisoning in the home following the accidental ingestion of a hygiene product by a healthy adult is very likely to result from these products being packaged like foodstuffs. Our hypothesis is that FIPs are non-verbal food metaphors that could fool the brain of consumers. We therefore conducted a subsequent functional neuroimaging (fMRI) experiment that revealed how visual processing of FIPs leads to cortical taste inferences. Considered in the grounded cognition perspective, the results of our studies reveal that healthy adults can unintentionally categorize a personal care product as something edible when a food-like package is employed to market nonedible and/or dangerous products. Our methodology combining field (qualitative) and laboratory (behavioral and functional neuroimaging) findings could be of particular relevance for policy makers, as it can help screening products prior to their market release--e.g. the way they are packaged and how they can potentially confuse the mind of consumers--and therefore save lives.

The ER Contact Proteins VAPA/B Interact with Multiple Autophagy Proteins to Modulate Autophagosome Biogenesis.

PubMed

Zhao, Yan G; Liu, Nan; Miao, Guangyan; Chen, Yong; Zhao, Hongyu; Zhang, Hong

2018-04-23

The endoplasmic reticulum (ER) is the site of biogenesis of the isolation membrane (IM, autophagosome precursor) and forms extensive contacts with IMs during their expansion into double-membrane autophagosomes. Little is known about the molecular mechanism underlying the formation and/or maintenance of the ER/IM contact. The integral ER proteins VAPA and VAPB (VAPs) participate in establishing ER contacts with multiple membranes by interacting with different tethers. Here, we demonstrate that VAPs also modulate ER/IM contact formation. Depletion of VAPs impairs progression of IMs into autophagosomes. Upon autophagy induction, VAPs are recruited to autophagosome formation sites on the ER, a process mediated by their interactions with FIP200 and PI(3)P. VAPs directly interact with FIP200 and ULK1 through their conserved FFAT motifs and stabilize the ULK1/FIP200 complex at the autophagosome formation sites on the ER. The formation of ULK1 puncta is significantly reduced by VAPA/B depletion. VAPs also interact with WIPI2 and enhance the formation of the WIPI2/FIP200 ER/IM tethering complex. Depletion of VMP1, which increases the ER/IM contact, greatly elevates the interaction of VAPs with these autophagy proteins. The VAPB P56S mutation, which is associated with amyotrophic lateral sclerosis, reduces the ULK1/FIP200 interaction and impairs autophagy at an early step, similar to the effect seen in VAPA/B-depleted cells. Our study reveals that VAPs directly interact with multiple ATG proteins, thereby contributing to ER/IM contact formation for autophagosome biogenesis. Copyright © 2018 Elsevier Ltd. All rights reserved.

Why People Drink Shampoo? Food Imitating Products Are Fooling Brains and Endangering Consumers for Marketing Purposes

PubMed Central

Basso, Frédéric; Robert-Demontrond, Philippe; Hayek, Maryvonne; Anton, Jean-Luc; Nazarian, Bruno; Roth, Muriel; Oullier, Olivier

2014-01-01

A Food Imitating Product (FIP) is a household cleaner or a personal care product that exhibits food attributes in order to enrich consumption experience. As revealed by many cases worldwide, such a marketing strategy led to unintentional self-poisonings and deaths. FIPs therefore constitute a very serious health and public policy issue. To understand why FIPs are a threat, we first conducted a qualitative analysis on real-life cases of household cleaners and personal care products-related phone calls at a poison control center followed by a behavioral experiment. Unintentional self-poisoning in the home following the accidental ingestion of a hygiene product by a healthy adult is very likely to result from these products being packaged like foodstuffs. Our hypothesis is that FIPs are non-verbal food metaphors that could fool the brain of consumers. We therefore conducted a subsequent functional neuroimaging (fMRI) experiment that revealed how visual processing of FIPs leads to cortical taste inferences. Considered in the grounded cognition perspective, the results of our studies reveal that healthy adults can unintentionally categorize a personal care product as something edible when a food-like package is employed to market nonedible and/or dangerous products. Our methodology combining field (qualitative) and laboratory (behavioral and functional neuroimaging) findings could be of particular relevance for policy makers, as it can help screening products prior to their market release – e.g. the way they are packaged and how they can potentially confuse the mind of consumers – and therefore save lives. PMID:25207971

Mechanism for the decrease in the FIP1L1-PDGFRalpha protein level in EoL-1 cells by histone deacetylase inhibitors.

PubMed

Ishihara, Kenji; Kaneko, Motoko; Kitamura, Hajime; Takahashi, Aki; Hong, Jang Ja; Seyama, Toshio; Iida, Koji; Wada, Hiroshi; Hirasawa, Noriyasu; Ohuchi, Kazuo

2008-01-01

Acetylation and deacetylation of proteins occur in cells in response to various stimuli, and are reversibly catalyzed by histone acetyltransferase and histone deacetylase (HDAC), respectively. EoL-1 cells have an FIP1L1-PDGFRA fusion gene that causes transformation of eosinophilic precursor cells into leukemia cells. The HDAC inhibitors apicidin and n-butyrate suppress the proliferation of EoL-1 cells and induce differentiation into eosinophils by a decrease in the protein level of FIP1L1-PDGFRalpha without affecting the mRNA level for FIP1L1-PDGFRA. In this study, we analyzed the mechanism by which the protein level of FIP1L1-PDGFRalpha is decreased by apicidin and n-butyrate. EoL-1 cells were incubated in the presence of the HDAC inhibitors apicidin, trichostatin A or n-butyrate. The protein levels of FIP1L1-PDGFRalpha and phosphorylated eIF-2alpha were determined by Western blotting. Actinomycin D and cycloheximide were used to block RNA synthesis and protein synthesis, respectively, in the chasing experiment of the amount of FIP1L1-PDGFRalpha protein. When apicidin- and n-butyrate-treated EoL-1 cells were incubated in the presence of actinomycin D, the decrease in the protein level of FIP1L1-PDGFRalpha was significantly enhanced when compared with controls. In contrast, the protein levels were not changed by cycloheximide among these groups. Apicidin and n-butyrate induced the continuous phosphorylation of eIF-2alpha for up to 8 days. The decrease in the level of FIP1L1-PDGFRalpha protein by continuous inhibition of HDAC may be due to the decrease in the translation rate of FIP1L1-PDGFRA. Copyright 2008 S. Karger AG, Basel.

The Zinc-Finger Thylakoid-Membrane Protein FIP Is Involved With Abiotic Stress Response in Arabidopsis thaliana.

PubMed

Lopes, Karina L; Rodrigues, Ricardo A O; Silva, Marcos C; Braga, Wiliane G S; Silva-Filho, Marcio C

2018-01-01

Many plant genes have their expression modulated by stress conditions. Here, we used Arabidopsis FtsH5 protease, which expression is regulated by light stress, as bait in a yeast two-hybrid screen to search for new proteins involved in the stress response. As a result, we found FIP (FtsH5 Interacting Protein), which possesses an amino proximal cleavable transit peptide, a hydrophobic membrane-anchoring region, and a carboxyl proximal C 4 -type zinc-finger domain. In vivo experiments using FIP fused to green fluorescent protein (GFP) showed a plastid localization. This finding was corroborated by chloroplast import assays that showed FIP inserted in the thylakoid membrane. FIP expression was down-regulated in plants exposed to high light intensity, oxidative, salt, and osmotic stresses, whereas mutant plants expressing low levels of FIP were more tolerant to these abiotic stresses. Our data shows a new thylakoid-membrane protein involved with abiotic stress response in Arabidopsis thaliana .

48 CFR 1304.1301 - Policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Policy. 1304.1301 Section 1304.1301 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE GENERAL ADMINISTRATIVE MATTERS... Standards Publication (FIPS PUB) 201 and OMB guidance M-05-24 is set forth in DOC Personal Identify...

The "FIP Effect" and the Origins of Solar Energetic Particles and of the Solar Wind

NASA Astrophysics Data System (ADS)

Reames, Donald V.

2018-03-01

We find that the element abundances in solar energetic particles (SEPs) and in the slow solar wind (SSW), relative to those in the photosphere, show different patterns as a function of the first ionization potential (FIP) of the elements. Generally, the SEP and SSW abundances reflect abundance samples of the solar corona, where low-FIP elements, ionized in the chromosphere, are more efficiently conveyed upward to the corona than high-FIP elements that are initially neutral atoms. Abundances of the elements, especially C, P, and S, show a crossover from low to high FIP at {≈} 10 eV in the SEPs but {≈} 14 eV for the solar wind. Naively, this seems to suggest cooler plasma from sunspots beneath active regions. More likely, if the ponderomotive force of Alfvén waves preferentially conveys low-FIP ions into the corona, the source plasma that eventually will be shock-accelerated as SEPs originates in magnetic structures where Alfvén waves resonate with the loop length on closed magnetic field lines. This concentrates FIP fractionation near the top of the chromosphere. Meanwhile, the source of the SSW may lie near the base of diverging open-field lines surrounding, but outside of, active regions, where such resonance does not exist, allowing fractionation throughout the chromosphere. We also find that energetic particles accelerated from the solar wind itself by shock waves at corotating interaction regions, generally beyond 1 AU, confirm the FIP pattern of the solar wind.

Microstructure and mesh sensitivities of mesoscale surrogate driving force measures for transgranular fatigue cracks in polycrystals

DOE Office of Scientific and Technical Information (OSTI.GOV)

Castelluccio, Gustavo M.; McDowell, David L.

The number of cycles required to form and grow microstructurally small fatigue cracks in metals exhibits substantial variability, particularly for low applied strain amplitudes. This variability is commonly attributed to the heterogeneity of cyclic plastic deformation within the microstructure, and presents a challenge to minimum life design of fatigue resistant components. Our paper analyzes sources of variability that contribute to the driving force of transgranular fatigue cracks within nucleant grains. We also employ crystal plasticity finite element simulations that explicitly render the polycrystalline microstructure and Fatigue Indicator Parameters (FIPs) averaged over different volume sizes and shapes relative to the anticipatedmore » fatigue damage process zone. Volume averaging is necessary to both achieve description of a finite fatigue damage process zone and to regularize mesh dependence in simulations. Furthermore, results from constant amplitude remote applied straining are characterized in terms of the extreme value distributions of volume averaged FIPs. Grain averaged FIP values effectively mitigate mesh sensitivity, but they smear out variability within grains. Furthermore, volume averaging over bands that encompass critical transgranular slip planes appear to present the most attractive approach to mitigate mesh sensitivity while preserving variability within grains.« less

Microstructure and mesh sensitivities of mesoscale surrogate driving force measures for transgranular fatigue cracks in polycrystals

DOE PAGES

Castelluccio, Gustavo M.; McDowell, David L.

2015-05-22

The number of cycles required to form and grow microstructurally small fatigue cracks in metals exhibits substantial variability, particularly for low applied strain amplitudes. This variability is commonly attributed to the heterogeneity of cyclic plastic deformation within the microstructure, and presents a challenge to minimum life design of fatigue resistant components. Our paper analyzes sources of variability that contribute to the driving force of transgranular fatigue cracks within nucleant grains. We also employ crystal plasticity finite element simulations that explicitly render the polycrystalline microstructure and Fatigue Indicator Parameters (FIPs) averaged over different volume sizes and shapes relative to the anticipatedmore » fatigue damage process zone. Volume averaging is necessary to both achieve description of a finite fatigue damage process zone and to regularize mesh dependence in simulations. Furthermore, results from constant amplitude remote applied straining are characterized in terms of the extreme value distributions of volume averaged FIPs. Grain averaged FIP values effectively mitigate mesh sensitivity, but they smear out variability within grains. Furthermore, volume averaging over bands that encompass critical transgranular slip planes appear to present the most attractive approach to mitigate mesh sensitivity while preserving variability within grains.« less

Comparison of the performance of laboratory tests in the diagnosis of feline infectious peritonitis.

PubMed

Stranieri, Angelica; Giordano, Alessia; Paltrinieri, Saverio; Giudice, Chiara; Cannito, Valentina; Lauzi, Stefania

2018-05-01

We compared the performance of clinicopathologic and molecular tests used in the antemortem diagnosis of feline infectious peritonitis (FIP). From 16 FIP and 14 non-FIP cats, we evaluated retrospectively the sensitivity, specificity, and likelihood ratios (LRs) of serum protein electrophoresis, α 1 -acid glycoprotein (AGP) on peripheral blood, screening reverse-transcription nested PCR (RT-nPCR) on the 3'-untranslated region (3'-UTR), and spike (S) gene sequencing on peripheral blood, body cavity effusions, and tissue, as well as body cavity cytology and delta total nucleated cell count (ΔTNC). Any of these tests on blood, and especially the molecular tests, may support or confirm a clinical diagnosis of FIP. A negative result does not exclude the disease except for AGP. Cytology, 3'-UTR PCR, and ΔTNC may confirm a clinical diagnosis on effusions; cytology or 3'-UTR PCR may exclude FIP. Conversely, S gene sequencing is not recommended based on the LRs. On tissues, S gene sequencing is preferable when histology is highly consistent with FIP, and 3'-UTR PCR when FIP is unlikely. Combining one test with high LR+ with one with low LR- (e.g., molecular tests and AGP on blood, ΔTNC and cytology in effusions) may improve the diagnostic power of the most used laboratory tests.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baker, D.; Van Driel-Gesztelyi, L.; Green, L. M.

Using spectra obtained by the EUV Imaging Spectrometer (EIS) instrument onboard Hinode, we present a detailed spatially resolved abundance map of an active region (AR)-coronal hole (CH) complex that covers an area of 359'' × 485''. The abundance map provides first ionization potential (FIP) bias levels in various coronal structures within the large EIS field of view. Overall, FIP bias in the small, relatively young AR is 2-3. This modest FIP bias is a consequence of the age of the AR, its weak heating, and its partial reconnection with the surrounding CH. Plasma with a coronal composition is concentrated atmore » AR loop footpoints, close to where fractionation is believed to take place in the chromosphere. In the AR, we found a moderate positive correlation of FIP bias with nonthermal velocity and magnetic flux density, both of which are also strongest at the AR loop footpoints. Pathways of slightly enhanced FIP bias are traced along some of the loops connecting opposite polarities within the AR. We interpret the traces of enhanced FIP bias along these loops to be the beginning of fractionated plasma mixing in the loops. Low FIP bias in a sigmoidal channel above the AR's main polarity inversion line, where ongoing flux cancellation is taking place, provides new evidence of a bald patch magnetic topology of a sigmoid/flux rope configuration.« less

The Nature of Variations in Anomalies of the Chemical Composition of the Solar Corona with the 11-Year Cycle

NASA Astrophysics Data System (ADS)

Pipin, V. V.; Tomozov, V. M.

2018-04-01

Evidence that the distribution of the abundances of admixtures with low first-ionization potentials (FIP < 10 eV) in the lower solar corona could be associated with the typology of the largescale magnetic field is presented. Solar observations show an enhancement in the abundances of elements with low FIPs compared to elements with high FIPs (>10 eV) in active regions and closed magnetic configurations in the lower corona. Observations with the ULYSSES spacecraft and at the Stanford Solar Observatory have revealed strong correlations between the manifestation of the FIP effect in the solar wind, the strength of the open magnetic flux (without regard to sign), and the ratio of the large-scale toroidal and poloidal magnetic fields at the solar surface. Analyses of observations of the Sun as a star show that the enhancement of the abundances of admixtures with low FIPs in the corona compared to their abundances in the photosphere (the FIP effect) is closely related to the solar-activity cycle and also with variations in the topology of the large-scale magnetic field. A possible mechanism for the relationship between the FIP effect and the spectral type of a star is discussed in the framework of solar-stellar analogies.

76 FR 38747 - Review of New Sources and Modifications in Indian Country

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-01

...The EPA is finalizing a Federal Implementation Plan (FIP) under the Clean Air Act (CAA or Act) for Indian country. The FIP includes two New Source Review (NSR) regulations for the protection of air resources in Indian country. The first rule applies to new and modified minor stationary sources (minor sources) and to minor modifications at existing major stationary sources (major sources) throughout Indian country. The second rule (nonattainment major NSR rule) applies to new and modified major sources in areas of Indian country that are designated as not attaining the National Ambient Air Quality Standards (NAAQS). These rules will be implemented by EPA or a delegate Tribal agency assisting EPA with administration of the rules, until replaced by an EPA-approved implementation plan.

Sunspots, Starspots, and Elemental Abundances

NASA Astrophysics Data System (ADS)

Doschek, George A.; Warren, Harry P.

2017-08-01

The composition of plasma in solar and stellar atmospheres is not fixed, but varies from feature to feature. These variations are organized by the First Ionization Potential (FIP) of the element. Solar measurements often indicate that low FIP elements (< 10eV, such as Fe, Si, Mg) are enriched by factors of 3-4 in the corona relative to high FIP elements (>10 eV, such as C, N, O, Ar, He) compared to abundances in the photosphere. Stellar observations have also shown similar enrichments. An inverse FIP effect, where the low FIP elements are depleted, has been observed in stellar coronae of stars believed to have large starspots in their photospheres. The abundances are important for determining radiative loss rates in models, tracing the origin of the slow solar wind, and for understanding wave propagation in the chromosphere and corona. Recently, inverse FIP effects have been discovered in the Sun (Doschek, Warren, & Feldman 2015, ApJ, 808, L7) from spectra obtained by the Extreme-ultraviolet Imaging Spectrometer (EIS) on the Hinode spacecraft. The inverse FIP regions seem always to be near sunspots and cover only a very small area (characteristic length = a few arcseconds). However, in pursuing the search for inverse FIP regions, we have found that in some sunspot groups the coronal abundance at a temperature of 3-4 MK can be near photospheric over much larger areas of the sun near the sunspots (e.g., 6,000 arcsec2). Also, sometimes the abundances at 3-4 MK are in between coronal and photospheric values. This can occur in small areas of an active region. It is predicted (Laming 2015, Sol. Phys., 12, 2) that the FIP effect should be highly variable in the corona. Several examples of coronal abundance variations are presented. Our work indicates that a comprehensive re-investigation of solar abundances is highly desirable. This work is supported by a NASA Hinode grant.

21 CFR 1311.08 - Incorporation by reference.

Code of Federal Regulations, 2014 CFR

2014-04-01

... the National Institute of Standards and Technology, Computer Security Division, Information Technology... Publication (FIPS PUB) 140-2, Change Notices (12-03-2002), Security Requirements for Cryptographic Modules... §§ 1311.30(b), 1311.55(b), 1311.115(b), 1311.120(b), 1311.205(b). (i) Annex A: Approved Security Functions...

Plasma Composition in a Sigmoidal Anemone Active Region

NASA Astrophysics Data System (ADS)

Baker, D.; Brooks, D. H.; Démoulin, P.; van Driel-Gesztelyi, L.; Green, L. M.; Steed, K.; Carlyle, J.

2013-11-01

Using spectra obtained by the EUV Imaging Spectrometer (EIS) instrument onboard Hinode, we present a detailed spatially resolved abundance map of an active region (AR)-coronal hole (CH) complex that covers an area of 359'' × 485''. The abundance map provides first ionization potential (FIP) bias levels in various coronal structures within the large EIS field of view. Overall, FIP bias in the small, relatively young AR is 2-3. This modest FIP bias is a consequence of the age of the AR, its weak heating, and its partial reconnection with the surrounding CH. Plasma with a coronal composition is concentrated at AR loop footpoints, close to where fractionation is believed to take place in the chromosphere. In the AR, we found a moderate positive correlation of FIP bias with nonthermal velocity and magnetic flux density, both of which are also strongest at the AR loop footpoints. Pathways of slightly enhanced FIP bias are traced along some of the loops connecting opposite polarities within the AR. We interpret the traces of enhanced FIP bias along these loops to be the beginning of fractionated plasma mixing in the loops. Low FIP bias in a sigmoidal channel above the AR's main polarity inversion line, where ongoing flux cancellation is taking place, provides new evidence of a bald patch magnetic topology of a sigmoid/flux rope configuration.

On an LAS-integrated soft PLC system based on WorldFIP fieldbus.

PubMed

Liang, Geng; Li, Zhijun; Li, Wen; Bai, Yan

2012-01-01

Communication efficiency is lowered and real-time performance is not good enough in discrete control based on traditional WorldFIP field intelligent nodes in case that the scale of control in field is large. A soft PLC system based on WorldFIP fieldbus was designed and implemented. Link Activity Scheduler (LAS) was integrated into the system and field intelligent I/O modules acted as networked basic nodes. Discrete control logic was implemented with the LAS-integrated soft PLC system. The proposed system was composed of configuration and supervisory sub-systems and running sub-systems. The configuration and supervisory sub-system was implemented with a personal computer or an industrial personal computer; running subsystems were designed and implemented based on embedded hardware and software systems. Communication and schedule in the running subsystem was implemented with an embedded sub-module; discrete control and system self-diagnosis were implemented with another embedded sub-module. Structure of the proposed system was presented. Methodology for the design of the sub-systems was expounded. Experiments were carried out to evaluate the performance of the proposed system both in discrete and process control by investigating the effect of network data transmission delay induced by the soft PLC in WorldFIP network and CPU workload on resulting control performances. The experimental observations indicated that the proposed system is practically applicable. Copyright © 2011 ISA. Published by Elsevier Ltd. All rights reserved.

Revision of the International Pharmaceutical Federation's Basel Statements on the future of hospital pharmacy: From Basel to Bangkok.

PubMed

Vermeulen, Lee C; Moles, Rebekah J; Collins, Jack C; Gray, Andy; Sheikh, Abdul Latif; Surugue, Jacqueline; Moss, Robert J; Ivey, Marianne F; Stevenson, James G; Takeda, Yasuo; Ranjit, Eurek; Chaar, Betty; Penm, Jonathan

2016-07-15

The processes used to revise the 2008 Basel Statements on the future of hospital pharmacy are summarized, and the revised statements are presented. The process for revising the Basel Statements followed an approach similar to that used during their initial development. The Hospital Pharmacy Section (HPS) of the International Pharmaceutical Federation (FIP) revised the 2008 FIP Basel Statements in four phases, including a survey of hospital pharmacists worldwide, an internal review, online forums, and a face-to-face "World Café" workshop in Bangkok, Thailand. The global survey on the initial Basel Statements included input from 334 respondents from 62 countries. The majority of respondents agreed that most of the initial Basel Statements were acceptable as written and did not require revision. In total, 11 statements were judged by more than 10% of respondents as needing revision or deletion. The FIP HPS executive committee used the survey results to develop 69 initial revised draft statements. After an online discussion with the international hospital pharmacy community, including individuals from 28 countries representing all six World Health Organization regions, a final set of draft statements was prepared for the live discussion involving participants from 20 countries. The final 65 revised Basel Statements were voted on and accepted. Systematic revision of the FIP Basel Statements resulted in an updated reflection of aspirational goals for the future of hospital pharmacy practice. While this revision reflects the development of new goals for hospital pharmacy practice, the core principles of the Basel Statements remain an essential foundation for the discipline. Copyright © 2016 by the American Society of Health-System Pharmacists, Inc. All rights reserved.

Department of Defense Finance and Accounting Service FY 1996/1997 Biennial Budget Estimates, February 1995.

DTIC Science & Technology

1995-02-01

Descriptive Summary 2 FIP Resources and Indefinite Delivery - Quantity Contracts 3 Central Design Activity Summary 4 Accesion For NTIS CRA&IDTIC TAB...interface with financial systems should be integrated into the standard architecture of the Military Departments iii to ensure maximum cost...provided to support and maintain the DFAS enterprise local area network initiative to establish a standardized architecture for office automation and

40 CFR 52.2141 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 5 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of sulfur dioxide? 52.2141 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of sulfur dioxide? (a) The...

Finnish Prenatal Study of Autism and Autism Spectrum Disorders (FIPS-A): Overview and Design

ERIC Educational Resources Information Center

Lampi, Katja M.; Banerjee, P. Nina; Gissler, Mika; Hinkka-Yli-Salomaki, Susanna; Huttunen, Jukka; Kulmala, Ulla; Lindroos, Jarna; Niemela, Solja; Rihko, Maria; Ristkari, Terja; Saanakorpi, Kristiina; Sarlin, Tanja; Sillanmaki, Lauri; McKeague, Ian W.; Surcel, Helja-Marja; Helenius, Hans; Brown, Alan S.; Sourander, Andre

2011-01-01

This article presents an overview of the Finnish Prenatal Study of Autism and Autism Spectrum Disorders (FIPS-A), a new study designed to examine the relationship between prenatal serologic factors, mediating and moderating developmental antecedents, and risk of autism spectrum disorders (ASD). The FIPS-A is based on register linkages between…

40 CFR 52.184 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 3 2014-07-01 2014-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.184 Section 52... provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a) The owner and...

40 CFR 52.2540 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 5 2014-07-01 2014-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.2540 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.1930 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 4 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1930 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a) The...

40 CFR 52.54 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 3 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.54 Section 52.54... FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and operator of each...

40 CFR 52.1084 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 4 2014-07-01 2014-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1084 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.484 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 3 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.484 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.1784 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 4 2014-07-01 2014-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1784 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.789 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 3 2014-07-01 2014-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.789 Section 52... provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and...

40 CFR 52.984 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 3 2014-07-01 2014-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.984 Section 52... provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and...

40 CFR 52.584 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 3 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.584 Section 52... provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and...

40 CFR 52.840 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 3 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.840 Section 52...; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and...

40 CFR 52.2440 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 5 2014-07-01 2014-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.2440 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.731 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 3 2014-07-01 2014-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.731 Section 52... provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and...

40 CFR 52.1326 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 4 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1326 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.1284 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 4 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1284 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a) The...

40 CFR 52.2040 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 5 2014-07-01 2014-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.2040 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.840 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 3 2014-07-01 2014-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.840 Section 52...; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and...

40 CFR 52.1584 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 4 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1584 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.2283 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 4 2011-07-01 2011-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.2283 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.540 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 3 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.540 Section 52... provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a) The owner and...

40 CFR 52.984 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 3 2010-07-01 2010-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.984 Section 52... provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and...

40 CFR 52.1084 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 4 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1084 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.1584 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 4 2014-07-01 2014-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1584 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.2240 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 5 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.2240 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.1882 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 4 2014-07-01 2014-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1882 Section 52... provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and...

40 CFR 52.2283 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 5 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.2283 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.484 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 3 2011-07-01 2011-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.484 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.484 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 3 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.484 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.584 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 3 2014-07-01 2014-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.584 Section 52... provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and...

40 CFR 52.440 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 3 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.440 Section 52... provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and...

40 CFR 52.2140 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 4 2010-07-01 2010-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.2140 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.2240 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 5 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.2240 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.2240 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 4 2011-07-01 2011-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.2240 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.54 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 3 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.54 Section 52.54... FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and operator of each...

40 CFR 52.484 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 3 2010-07-01 2010-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.484 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.2240 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 4 2010-07-01 2010-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.2240 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.1584 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 4 2010-07-01 2010-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1584 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.2240 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 5 2014-07-01 2014-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.2240 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.1784 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 4 2010-07-01 2010-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1784 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.1428 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 4 2014-07-01 2014-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1428 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a) The...

40 CFR 52.1684 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 4 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1684 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.882 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 3 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.882 Section 52...; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and...

40 CFR 52.1882 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 4 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1882 Section 52... provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and...

40 CFR 52.440 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 3 2010-07-01 2010-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.440 Section 52... provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and...

40 CFR 52.1186 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 4 2011-07-01 2011-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1186 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.1326 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 4 2014-07-01 2014-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1326 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.2140 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 5 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.2140 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.984 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 3 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.984 Section 52... provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and...

40 CFR 52.2140 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 4 2011-07-01 2011-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.2140 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.1428 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 4 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1428 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a) The...

40 CFR 52.2440 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 5 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.2440 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.2540 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 5 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.2540 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.984 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 3 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.984 Section 52... provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and...

40 CFR 52.1326 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 4 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1326 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.1186 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 4 2014-07-01 2014-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1186 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.940 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 3 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.940 Section 52... provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and...

40 CFR 52.789 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 3 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.789 Section 52... provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and...

40 CFR 52.940 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 3 2014-07-01 2014-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.940 Section 52... provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and...

40 CFR 52.2040 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 5 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.2040 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.984 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 3 2011-07-01 2011-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.984 Section 52... provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and...

40 CFR 52.1930 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 4 2014-07-01 2014-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1930 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a) The...

40 CFR 52.2140 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 5 2014-07-01 2014-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.2140 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.540 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 3 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.540 Section 52... provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a) The owner and...

40 CFR 52.1284 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 4 2014-07-01 2014-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1284 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a) The...

40 CFR 52.1784 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 4 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1784 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.2540 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 5 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.2540 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.940 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 3 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.940 Section 52... provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and...

40 CFR 52.584 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 3 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.584 Section 52... provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and...

40 CFR 52.1784 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 4 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1784 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.440 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 3 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.440 Section 52... provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and...

40 CFR 52.1930 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 4 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1930 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a) The...

40 CFR 52.1784 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 4 2011-07-01 2011-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1784 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.1084 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 4 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1084 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.1186 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 4 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1186 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.2283 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 4 2010-07-01 2010-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.2283 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.789 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 3 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.789 Section 52... provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and...

40 CFR 52.484 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 3 2014-07-01 2014-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.484 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.2440 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 5 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.2440 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.2040 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 5 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.2040 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.840 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 3 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.840 Section 52...; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and...

40 CFR 52.882 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 3 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.882 Section 52...; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and...

40 CFR 52.1186 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 4 2010-07-01 2010-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1186 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.54 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 3 2014-07-01 2014-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.54 Section 52.54... FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and operator of each...

40 CFR 52.789 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 3 2010-07-01 2010-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.789 Section 52... provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and...

40 CFR 52.1584 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 4 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1584 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.1186 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 4 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1186 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.1684 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 4 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1684 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.184 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 3 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.184 Section 52... provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a) The owner and...

40 CFR 52.2140 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 5 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.2140 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.1428 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 4 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1428 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a) The...

40 CFR 52.1882 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 4 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1882 Section 52... provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and...

40 CFR 52.1684 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 4 2011-07-01 2011-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1684 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.440 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 3 2014-07-01 2014-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.440 Section 52... provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and...

40 CFR 52.540 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 3 2014-07-01 2014-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.540 Section 52... provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a) The owner and...

40 CFR 52.1684 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 4 2014-07-01 2014-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1684 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.2283 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 5 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.2283 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.1284 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 4 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1284 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a) The...

40 CFR 52.882 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 3 2014-07-01 2014-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.882 Section 52...; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and...

40 CFR 52.731 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 3 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.731 Section 52... provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and...

40 CFR 52.440 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 3 2011-07-01 2011-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.440 Section 52... provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1) The owner and...

40 CFR 52.2283 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 5 2014-07-01 2014-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.2283 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.1584 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 4 2011-07-01 2011-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.1584 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a)(1...

40 CFR 52.184 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 3 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? 52.184 Section 52... provisions; What are the FIP requirements for decreases in emissions of nitrogen oxides? (a) The owner and...

40 CFR 52.2441 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 5 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of sulfur dioxide? 52.2441 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of sulfur dioxide? (a) The...

40 CFR 52.485 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 3 2011-07-01 2011-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of sulfur dioxide? 52.485 Section 52.485...; What are the FIP requirements for decreases in emissions of sulfur dioxide? The owner and operator of...

40 CFR 52.2541 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 5 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of sulfur dioxide? 52.2541 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of sulfur dioxide? (a) The...

40 CFR 52.732 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 3 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of sulfur dioxide? 52.732 Section 52.732... FIP requirements for decreases in emissions of sulfur dioxide? (a) The owner and operator of each...

40 CFR 52.2284 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 5 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of sulfur dioxide? 52.2284 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of sulfur dioxide? (a) The...

40 CFR 52.55 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 3 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of sulfur dioxide? 52.55 Section 52.55... FIP requirements for decreases in emissions of sulfur dioxide? (a) The owner and operator of each...

40 CFR 52.2241 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 5 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of sulfur dioxide? 52.2241 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of sulfur dioxide? (a) The...

40 CFR 52.585 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 3 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of sulfur dioxide? 52.585 Section 52.585... FIP requirements for decreases in emissions of sulfur dioxide? (a) The owner and operator of each...

40 CFR 52.441 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 3 2011-07-01 2011-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of sulfur dioxide? 52.441 Section 52.441... FIP requirements for decreases in emissions of sulfur dioxide? The owner and operator of each SO2...

40 CFR 52.941 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 3 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of sulfur dioxide? 52.941 Section 52.941... FIP requirements for decreases in emissions of sulfur dioxide? (a) The owner and operator of each...

40 CFR 52.2588 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 5 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of sulfur dioxide? 52.2588 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of sulfur dioxide? (a) The...

40 CFR 52.441 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 3 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of sulfur dioxide? 52.441 Section 52.441... FIP requirements for decreases in emissions of sulfur dioxide? (a) The owner and operator of each SO2...

40 CFR 52.485 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 3 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of sulfur dioxide? 52.485 Section 52.485...; What are the FIP requirements for decreases in emissions of sulfur dioxide? (a) The owner and operator...

40 CFR 52.883 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 3 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of sulfur dioxide? 52.883 Section 52.883... FIP requirements for decreases in emissions of sulfur dioxide? (a) The owner and operator of each...

40 CFR 52.790 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 3 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of sulfur dioxide? 52.790 Section 52.790... FIP requirements for decreases in emissions of sulfur dioxide? (a) The owner and operator of each...

40 CFR 52.2041 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 5 2013-07-01 2013-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of sulfur dioxide? 52.2041 Section 52... transport provisions; What are the FIP requirements for decreases in emissions of sulfur dioxide? (a) The...

On the differences in element abundances of energetic ions from corotating events and from large solar events

NASA Technical Reports Server (NTRS)

Reames, D. V.; Richardson, I. G.; Barbier, L. M.

1991-01-01

The abundances of energetic ions accelerated from high-speed solar wind streams by shock waves formed at corotating interaction regions (CIRs) where high-speed streams overtake the lower-speed solar wind are examined. The observed element abundances appear to represent those of the high-speed solar wind, unmodified by the shock acceleration. These abundances, relative to those in the solar photosphere, are organized by the first ionization potential (FIP) of the ions in a way that is different from the FIP effect commonly used to describe differences between abundances in the solar photosphere and those in the solar corona, solar energetic particles (SEPs), and the low-speed solar wind. In contrast, the FIP effect of the ion abundances in the CIR events is characterized by a smaller amplitude of the differences between high-FIP and low-FIP ions and by elevated abundances of He, C, and S.

Preliminary estimates of annual agricultural pesticide use for counties of the conterminous United States, 2010-11

USGS Publications Warehouse

Baker, Nancy T.; Stone, Wesley W.

2013-01-01

This report provides preliminary estimates of annual agricultural use of 374 pesticide compounds in counties of the conterminous United States in 2010 and 2011, compiled by means of methods described in Thelin and Stone (2013). U.S. Department of Agriculture (USDA) county-level data for harvested-crop acreage were used in conjunction with proprietary Crop Reporting District (CRD)-level pesticide-use data to estimate county-level pesticide use. Estimated pesticide use (EPest) values were calculated with both the EPest-high and EPest-low methods. The distinction between the EPest-high method and the EPest-low method is that there are more counties with estimated pesticide use for EPest-high compared to EPest-low, owing to differing assumptions about missing survey data (Thelin and Stone, 2013). Preliminary estimates in this report will be revised upon availability of updated crop acreages in the 2012 Agricultural Census, to be published by the USDA in 2014. In addition, estimates for 2008 and 2009 previously published by Stone (2013) will be updated subsequent to the 2012 Agricultural Census release. Estimates of annual agricultural pesticide use are provided as downloadable, tab-delimited files, which are organized by compound, year, state Federal Information Processing Standard (FIPS) code, county FIPS code, and kg (amount in kilograms).

77 FR 75383 - Approval and Promulgation of Air Quality Implementation Plans; Illinois; Infrastructure SIP...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-20

... Requirements for the 2006 PM 2.5 NAAQS; Revisions to FIPs To Reduce Interstate Transport of PM 2.5 and Ozone..., 2011, and February 21, 2012, actions pertain to Federal Implementation Plans (FIPs) to reduce... August 8, 2011, (76 FR 48208), EPA published FIPs to reduce interstate transport of PM 2.5 and ozone. It...

Angioimmunoblastic T-cell lymphoma and hypereosinophilic syndrome with FIP1L1/PDGFRA fusion gene effectively treated with imatinib: A case report.

PubMed

Yamamoto, Masayo; Ikuta, Katsuya; Toki, Yasumichi; Hatayama, Mayumi; Shindo, Motohiro; Torimoto, Yoshihiro; Okumura, Toshikatsu

2017-09-01

Hypereosinophilic syndrome (HES) is a rare disorder characterized by hypereosinophilia and organ damage. Some cases of HES are caused by the FIP1L1/PDGFRA fusion gene and respond to imatinib. FIP1L1/PDGFRA-positive HES occasionally evolves into chronic eosinophilic leukemia or into another form of myeloproliferative neoplasm; however, the development of a malignant lymphoma is very rare. We present a rare case of angioimmunoblastic T-cell lymphoma (AITL) and HES with the FIP1L1/PDGFRA gene rearrangement. A man in his 30s presented to our hospital with fever, hypereosinophilia, widespread lymphadenopathy, and splenomegaly. Laboratory tests showed hypereosinophilia, increased soluble interleukin-2 receptor, and increased vitamin B12. Positron-emission tomography with F fluorodeoxyglucose (FDG) showed positive FDG uptake in multiple enlarged lymph nodes throughout the body and the red bone marrow. A bone-marrow biopsy showed hypereosinophilia without dysplasia and an increased number of blasts. The FIP1L1/PDGFRA fusion gene was positive upon fluorescence in situ hybridization (FISH) analysis of the peripheral blood. Furthermore, biopsy of a lymph node from the neck revealed restiform hyperplasia of capillary vessels, with small lymphoma cells arranged around the capillaries. Lymphoma cells were positive for CD3, CD4, and CD10, and negative for CD20. Lymphoma cells were also positive for the FIP1L1/PDGFRA fusion gene by FISH analysis. From these findings, the patient was diagnosed with HES and AITL with FIP1L1/PDGFRA. After the diagnosis, corticosteroid was administered but was ineffective. Imatinib was then administered. Imatinib was very effective for treating HES and AITL, and complete remission was achieved in both. This report presents the first case in which the FIP1L1/PDGFRA fusion gene was positive both in peripheral blood and lymph nodes, implying the possibility that the tumor cells acquired the FIP1L1/PDGFRA fusion gene in the early stage of hematopoietic progenitor cell developments. Imatinib was very effective in treating both HES and lymphoma, suggesting that the FIP1L1/PDGFRA fusion gene plays a key role in the pathogenesis of both HES and lymphoma.

Coronae of Stars with Supersolar Elemental Abundances

NASA Technical Reports Server (NTRS)

Peretz, Uria; Behar, Ehud; Drake, Stephen A.

2015-01-01

Coronal elemental abundances are known to deviate from the photospheric values of their parent star, with the degree of deviation depending on the first ionization potential (FIP). This study focuses on the coronal composition of stars with supersolar photospheric abundances. We present the coronal abundances of six such stars: 11 LMi, iota Hor, HR 7291, tau Boo, and alpha Cen A and B. These stars all have high-statistics X-ray spectra, three of which are presented for the first time. The abundances we measured were obtained using the line-resolved spectra of the Reflection Grating Spectrometer (RGS) in conjunction with the higher throughput EPIC-pn camera spectra onboard the XMM-Newton observatory. A collisionally ionized plasma model with two or three temperature components is found to represent the spectra well. All elements are found to be consistently depleted in the coronae compared to their respective photospheres. For 11 LMi and tau Boo no FIP effect is present, while iota Hor, HR 7291, and alpha Cen A and B show a clear FIP trend. These conclusions hold whether the comparison is made with solar abundances or the individual stellar abundances. Unlike the solar corona, where low-FIP elements are enriched, in these stars the FIP effect is consistently due to a depletion of high-FIP elements with respect to actual photospheric abundances. A comparison with solar (instead of stellar) abundances yields the same fractionation trend as on the Sun. In both cases, a similar FIP bias is inferred, but different fractionation mechanisms need to be invoked.

Papular cutaneous lesions in a cat associated with feline infectious peritonitis.

PubMed

Declercq, Jan; De Bosschere, Hendrik; Schwarzkopf, Ilona; Declercq, Lies

2008-10-01

A 7-month-old-intact male domestic shorthair cat was presented with fever, anterior uveitis in the right eye and respiratory distress when handled. These signs along with mild changes in serum protein levels and the exclusion of other potential causes were suggestive of feline infectious peritonitis (FIP). As the disease progressed, more clinical signs consistent with FIP, including renal involvement and later pleural effusion, became evident. Non-pruritic cutaneous lesions, characterized by slightly raised intradermal papules over the dorsal neck and over both lateral thoracic walls, were recognized at the end stage of the disease. The identification of papules in well-haired skin was difficult, and clipping of the fur facilitated their detection. Definitive diagnosis of FIP was made by histopathology and by immunohistochemical demonstration of coronavirus antigen in macrophages within kidney and skin lesions. The case was classified as a mixed form of FIP. Recognition of associated cutaneous lesions may facilitate a diagnosis of FIP in suspicious cases.

76 FR 52387 - Approval and Promulgation of Implementation Plans; New Mexico; Federal Implementation Plan for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-22

...EPA is disapproving a portion of the State Implementation Plan (SIP) revision received from the State of New Mexico on September 17, 2007, for the purpose of addressing the ``good neighbor'' requirements of section 110(a)(2)(D)(i) of the Clean Air Act (CAA or Act) for the 1997 8-hour ozone National Ambient Air Quality Standards (NAAQS or standards) and the 1997 fine particulate matter (PM2.5) NAAQS. In this action, EPA is disapproving the New Mexico Interstate Transport SIP provisions that address the requirement of section 110(a)(2)(D)(i)(II) that emissions from New Mexico sources do not interfere with measures required in the SIP of any other state under part C of the CAA to protect visibility. We have found that New Mexico sources, except the San Juan Generating Station, are sufficiently controlled to eliminate interference with the visibility programs of other states. EPA is promulgating a Federal Implementation Plan (FIP) to address this deficiency by implementing nitrogen oxides (NOX) and sulfur dioxide (SO2) emission limits necessary at the San Juan Generating Station (SJGS), to prevent such interference. EPA found in January 2009 that New Mexico had failed to submit a SIP addressing certain regional haze (RH) requirements, including the requirement for best available retrofit technology (BART). The Clean Air Act required EPA to promulgate a FIP to address RH requirements by January 2011. This FIP addresses the RH BART requirement for NOX for SJGS. In addition, EPA is implementing sulfuric acid (H2SO4) hourly emission limits at the SJGS, to minimize the contribution of this compound to visibility impairment. This action is being taken under section 110 and part C of the CAA.

77 FR 44064 - Federal Acquisition Regulation: Clarification of Standards for Computer Generation of Forms

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-26

... Federal Register at 73 FR 51276 on September 2, 2008, by the Department of Commerce. This FIPS requirement was withdrawn by the Secretary of Commerce because it was obsolete and had not been updated to adopt...) 12866 and 13563 direct agencies to assess all costs and benefits of available regulatory alternatives...

Dasatinib inhibits the growth and survival of neoplastic human eosinophils (EOL-1) through targeting of FIP1L1-PDGFRalpha.

PubMed

Baumgartner, Christian; Gleixner, Karoline V; Peter, Barbara; Ferenc, Veronika; Gruze, Alexander; Remsing Rix, Lily L; Bennett, Keiryn L; Samorapoompichit, Puchit; Lee, Francis Y; Pickl, Winfried F; Esterbauer, Harald; Sillaber, Christian; Superti-Furga, Giulio; Valent, Peter

2008-10-01

Chronic eosinophilic leukemia (CEL) is a myeloproliferative disorder characterized by molecular and/or cytogenetic evidence of clonality of eosinophils, marked eosinophilia, and organ damage. In many patients, the transforming mutation FIP1L1-PDGFRalpha and the related CHIC2 deletion are found. The respective oncoprotein, FIP1L1-PDGFRalpha, is considered to play a major role in malignant cell growth in CEL. The tyrosine kinase (TK) inhibitor imatinib (STI571) has been described to counteract the TK activity of FIP1L1-PDGFRalpha in most patients. However, not all patients with CEL show a response to imatinib. Therefore, several attempts have been made to identify other TK inhibitors that counteract growth of neoplastic eosinophils. We provide evidence that dasatinib, a multi-targeted kinase inhibitor, blocks the growth and survival of EOL-1, an eosinophil leukemia cell line carrying FIP1L1-PDGFRalpha. The effects of dasatinib on proliferation of EOL-1 cells were dose-dependent, with an IC50 of 0.5 to 1 nM, which was found to be in the same range when compared to IC50 values produced with imatinib. Dasatinib was also found to induce apoptosis in EOL-1 cells in a dose-dependent manner (IC50: 1-10 nM). The apoptosis-inducing effects of dasatinib on EOL-1 cells were demonstrable by light microscopy, flow cytometry, and in a TUNEL assay. In Western blot experiments, dasatinib completely blocked the phosphorylation of FIP1L1-PDGFRalpha in EOL-1 cells. Dasatinib inhibits the growth of leukemic eosinophils through targeting of the disease-related oncoprotein FIP1L1-PDGFRalpha. Based on this observation, dasatinib may be considered as a new interesting treatment option for patients with CEL.

Positive immunolabelling for feline infectious peritonitis in an African lion (Panthera leo) with bilateral panuveitis.

PubMed

Mwase, M; Shimada, K; Mumba, C; Yabe, J; Squarre, D; Madarame, H

2015-01-01

A 15-year-old male African lion (Panthera leo) was presented with blindness due to bilateral panuveitis with retinal detachment. Feline coronavirus (FCoV) antigen was identified immunohistochemically in ocular macrophages, consistent with a diagnosis of feline infectious peritonitis (FIP) infection. This is the first report of FIP in an African lion and the first report of ocular FIP in a non-domestic felid. Copyright © 2014 Elsevier Ltd. All rights reserved.

RELATIVE ABUNDANCE MEASUREMENTS IN PLUMES AND INTERPLUMES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Guennou, C.; Hahn, M.; Savin, D. W., E-mail: cguennou@iac.es

2015-07-10

We present measurements of relative elemental abundances in plumes and interplumes. Plumes are bright, narrow structures in coronal holes that extend along open magnetic field lines far out into the corona. Previous work has found that in some coronal structures the abundances of elements with a low first ionization potential (FIP) <10 eV are enhanced relative to their photospheric abundances. This coronal-to-photospheric abundance ratio, commonly called the FIP bias, is typically 1 for elements with a high-FIP (>10 eV). We have used Extreme Ultraviolet Imaging Spectrometer observations made on 2007 March 13 and 14 over a ≈24 hr period tomore » characterize abundance variations in plumes and interplumes. To assess their elemental composition, we used a differential emission measure analysis, which accounts for the thermal structure of the observed plasma. We used lines from ions of iron, silicon, and sulfur. From these we estimated the ratio of the iron and silicon FIP bias relative to that for sulfur. From the results, we have created FIP-bias-ratio maps. We find that the FIP-bias ratio is sometimes higher in plumes than in interplumes and that this enhancement can be time dependent. These results may help to identify whether plumes or interplumes contribute to the fast solar wind observed in situ and may also provide constraints on the formation and heating mechanisms of plumes.« less

Rab11-FIP3 Regulation of Lck Endosomal Traffic Controls TCR Signal Transduction.

PubMed

Bouchet, Jérôme; Del Río-Iñiguez, Iratxe; Vázquez-Chávez, Elena; Lasserre, Rémi; Agüera-González, Sonia; Cuche, Céline; McCaffrey, Mary W; Di Bartolo, Vincenzo; Alcover, Andrés

2017-04-01

The role of endosomes in receptor signal transduction is a long-standing question, which remains largely unanswered. The T cell Ag receptor and various components of its proximal signaling machinery are associated with distinct endosomal compartments, but how endosomal traffic affects T cell signaling remains ill-defined. In this article, we demonstrate in human T cells that the subcellular localization and function of the protein tyrosine kinase Lck depends on the Rab11 effector FIP3 (Rab11 family interacting protein-3). FIP3 overexpression or silencing and its ability to interact with Rab11 modify Lck subcellular localization and its delivery to the immunological synapse. Importantly, FIP3-dependent Lck localization controls early TCR signaling events, such as tyrosine phosphorylation of TCRζ, ZAP70, and LAT and intracellular calcium concentration, as well as IL-2 gene expression. Interestingly, FIP3 controls both steady-state and poststimulation phosphotyrosine and calcium levels. Finally, our findings indicate that FIP3 modulates TCR-CD3 cell surface expression via the regulation of steady-state Lck-mediated TCRζ phosphorylation, which in turn controls TCRζ protein levels. This may influence long-term T cell activation in response to TCR-CD3 stimulation. Therefore, our data underscore the importance of finely regulated endosomal traffic in TCR signal transduction and T cell activation leading to IL-2 production. Copyright © 2017 by The American Association of Immunologists, Inc.

Mechanism for the differentiation of EoL-1 cells into eosinophils by histone deacetylase inhibitors.

PubMed

Kaneko, Motoko; Ishihara, Kenji; Takahashi, Aki; Hong, Jangja; Hirasawa, Noriyasu; Zee, Okpyo; Ohuchi, Kazuo

2007-01-01

EoL-1 cells have a FIP1L1-PDGFRA fusion gene which causes the transformation of eosinophilic precursor cells into leukemia cells. Recently, we suggested that the induction of differentiation of EoL-1 cells into eosinophils by the HDAC inhibitors apicidin and n-butyrate is due to the continuous inhibition of HDACs. However, neither apicidin nor n-butyrate inhibited the expression of FIP1L1-PDGFRA mRNA, although both these inhibitors suppressed cell proliferation. Therefore, in this study, we analyzed whether the levels of FIP1L1-PDGFRalpha protein and phosphorylated-Stat5 involved in the signaling for the proliferation of EoL-1 cells are attenuated by HDAC inhibitors. EoL-1 cells were incubated in the presence of apicidin, TSA or n-butyrate. FIP1L1-PDGFRalpha and phosphorylated-Stat5 were detected by Western blotting. Treatment of EoL-1 cells with apicidin at 100 nM or n-butyrate at 500 microM decreased the levels of FIP1L1-PDGFRalpha protein and phosphorylated-Stat5, while that with trichostatin A at 30 nM did not. The decrease in the level of FIP1L1-PDGFRalpha protein caused by apicidin and n-butyrate might be one of the mechanisms by which EoL-1 cells are induced to differentiate into eosinophils by these HDAC inhibitors.

Perfluoroalkyl acids (PFAAs) in indoor and outdoor dusts around a mega fluorochemical industrial park in China: Implications for human exposure.

PubMed

Su, Hongqiao; Lu, Yonglong; Wang, Pei; Shi, Yajuan; Li, Qifeng; Zhou, Yunqiao; Johnson, Andrew C

2016-09-01

The manufacture of fluorochemicals can lead to high levels of perfluoroalkyl acids (PFAAs) contaminating the surrounding environment and consequently elevated exposure to the local residents. In this study, measurements of PFAAs associated with indoor and outdoor dusts around a mega fluorochemical industrial park (FIP) were made. Perfluorooctanoic acid (PFOA) and short-chain perfluoroalkyl carboxylic acids (C4-C7 PFCAs) were the predominant forms in all samples. The signature of the PFAAs in dusts in the local area matched that found within the FIP complex. The contamination plume in the local area could be linked to the prevailing wind direction starting from the FIP. The dust concentrations decreased exponentially with distance from the FIP (noticeably in the first 5km). PFAAs contamination could be detected at the furthest location, 20km away from the FIP. The concentrations of PFAAs were higher in indoor dust (73-13,500ng/g, median: 979ng/g) than those in outdoor dust (5-9495ng/g, median: 62ng/g) at every location. The highest estimated daily intake of PFOA via dust ingestion (26.0ng/kg·bw/day) was for toddlers (2-5years) living 2km away from the FIP, which is posing human health risk, though exposure remains within the provisional tolerable daily intake values. Copyright © 2016 Elsevier Ltd. All rights reserved.

Rare variants in RTEL1 are associated with familial interstitial pneumonia.

PubMed

Cogan, Joy D; Kropski, Jonathan A; Zhao, Min; Mitchell, Daphne B; Rives, Lynette; Markin, Cheryl; Garnett, Errine T; Montgomery, Keri H; Mason, Wendi R; McKean, David F; Powers, Julia; Murphy, Elissa; Olson, Lana M; Choi, Leena; Cheng, Dong-Sheng; Blue, Elizabeth Marchani; Young, Lisa R; Lancaster, Lisa H; Steele, Mark P; Brown, Kevin K; Schwarz, Marvin I; Fingerlin, Tasha E; Schwartz, David A; Lawson, William E; Loyd, James E; Zhao, Zhongming; Phillips, John A; Blackwell, Timothy S

2015-03-15

Up to 20% of cases of idiopathic interstitial pneumonia cluster in families, comprising the syndrome of familial interstitial pneumonia (FIP); however, the genetic basis of FIP remains uncertain in most families. To determine if new disease-causing rare genetic variants could be identified using whole-exome sequencing of affected members from FIP families, providing additional insights into disease pathogenesis. Affected subjects from 25 kindreds were selected from an ongoing FIP registry for whole-exome sequencing from genomic DNA. Candidate rare variants were confirmed by Sanger sequencing, and cosegregation analysis was performed in families, followed by additional sequencing of affected individuals from another 163 kindreds. We identified a potentially damaging rare variant in the gene encoding for regulator of telomere elongation helicase 1 (RTEL1) that segregated with disease and was associated with very short telomeres in peripheral blood mononuclear cells in 1 of 25 families in our original whole-exome sequencing cohort. Evaluation of affected individuals in 163 additional kindreds revealed another eight families (4.7%) with heterozygous rare variants in RTEL1 that segregated with clinical FIP. Probands and unaffected carriers of these rare variants had short telomeres (<10% for age) in peripheral blood mononuclear cells and increased T-circle formation, suggesting impaired RTEL1 function. Rare loss-of-function variants in RTEL1 represent a newly defined genetic predisposition for FIP, supporting the importance of telomere-related pathways in pulmonary fibrosis.

Profile development for the spatial data transfer standard

USGS Publications Warehouse

Szemraj, John A.; Fegeas, Robin G.; Tolar, Billy R.

1994-01-01

The Spatial Data Transfer Standard (SDTS), or Federal Information Processing Standard (FIPS) 173, is designed to support all types of spatial data. Implementing all of the standard's options at one time is impractical. Therefore, implementation of the SDTS is being accomplished through the use of profiles. Profiles are clearly defined, limited subsets of the SDTS created for use with a specific type or model of data and designed with as few options as possible. When a profile is proposed, specific choices are made for encoding possibilities that were not addressed, left optional, or left with numerous choices within the SDTS. Profile development is coordinated by the U.S. Geological Survey's SDTS Task Force. When completed, profiles are submitted to the National Institute of Standards and Technology (NIST) for approval as official amendments to the SDTS. The first profile, the Topological Vector Profile (TVP), has been completed. A Raster Profile has been tested and is being finalized for submission to the NIST. Other vector profiles, such as those for network and nontopological data, are also being considered as future implementation options for the SDTS.

Efficacy and tolerability of bromelain in patients with chronic rhinosinusitis--a pilot study.

PubMed

Büttner, L; Achilles, N; Böhm, M; Shah-Hosseini, K; Mösges, R

2013-01-01

To evaluate the efficacy, tolerability, and impact on quality of life (QoL) of bromelain tablets (500 FIP) in patients with chronic rhinosinusitis (CRS). In this prospective, open-label observational pilot study, 12 patients suffering from CRS with (CRS+NP) or without (CRS-NP) nasal polyps who had undergone prior sinus surgery were treated with bromelain tablets (500 FIP) for three months. Efficacy was evaluated using symptom scores (Total Symptom Scores: TSS); a Total Rhinoscopy Score (TRS) was also determined. QoL was assessed by using the German, adapted version of the Sinonasal Outcome Test 20 (SNOT-20 GAV). Treatment with bromelain tablets (500 FIP) improved TSS, TRS and SNOT-20 GAV on average. This treatment was found to be more effective, however, for CRS-NP than for CRS+NP. The average intake was six tablets, equivalent to a daily dosage of 3000 FIP. No adverse events were observed. Preliminary results indicate good tolerability, symptom control, and improvement in QoL for the treatment of CRS using bromelain tablets (500 FIP).

Secure Control Systems for the Energy Sector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, Rhett; Campbell, Jack; Hadley, Mark

2012-03-31

Schweitzer Engineering Laboratories (SEL) will conduct the Hallmark Project to address the need to reduce the risk of energy disruptions because of cyber incidents on control systems. The goals is to develop solutions that can be both applied to existing control systems and designed into new control systems to add the security measures needed to mitigate energy network vulnerabilities. The scope of the Hallmark Project contains four primary elements: 1. Technology transfer of the Secure Supervisory Control and Data Acquisition (SCADA) Communications Protocol (SSCP) from Pacific Northwest National Laboratories (PNNL) to Schweitzer Engineering Laboratories (SEL). The project shall use thismore » technology to develop a Federal Information Processing Standard (FIPS) 140-2 compliant original equipment manufacturer (OEM) module to be called a Cryptographic Daughter Card (CDC) with the ability to directly connect to any PC enabling that computer to securely communicate across serial to field devices. Validate the OEM capabilities with another vendor. 2. Development of a Link Authenticator Module (LAM) using the FIPS 140-2 validated Secure SCADA Communications Protocol (SSCP) CDC module with a central management software kit. 3. Validation of the CDC and Link Authenticator modules via laboratory and field tests. 4. Creation of documents that record the impact of the Link Authenticator to the operators of control systems and on the control system itself. The information in the documents can assist others with technology deployment and maintenance.« less

Defense Information Systems Agency Technical Integration Support (DISA- TIS). MUMPS Study.

DTIC Science & Technology

1993-01-01

usable in DoD, MUMPS must continue to improve in its support of DoD and OSE standards such as SQL , X-Windows, POSIX, PHIGS, etc. MUMPS and large AlSs...Language ( SQL ), X-Windows, and Graphical Kernel Services (GKS)) 2.2.2.3 FIPS Adoption by NIST The National Institute of Standards and Technology (NIST...many of the performance tuning mechanisms that must be performed explicitly with other systems. The VA looks forward to the SQL binding (1993 ANS) that

The Mysterious Case of the Solar Argon Abundance Near Sunspots in Flares

NASA Astrophysics Data System (ADS)

Doschek, George A.; Warren, Harry

2016-05-01

Recently Doschek et al. (2015, ApJL, 808, L7) reported on an observation of an enhancement of the abundance of Ar XIV relative to Ca XIV of about a factor of 30 near a sunspot during a flare, observed in spectra recorded by the Extreme-ultraviolet Imaging Spectrometer (EIS) on the Hinode spacecraft. This enhancement yields an argon/calcium abundance ratio 7 times greater than expected from the photospheric abundances. Such a large abundance anomaly is unprecedented in the solar atmosphere. We interpreted this result as due to an inverse First Ionization Potential (FIP) effect. Argon is a high-FIP element and calcium is a low-FIP element. In the published work two lines of Ar XIV were observed and one line was tentatively identified as an Ar XI line. The number of argon lines was limited by the limitations of the flare study that was executed. In this paper we report observing a similar enhancement in a full-CCD EIS flare spectrum in argon lines with reasonable statistics and lack of blending that lie within the EIS wavelength ranges. The observed lines include two Ar XI lines, four Ar XIII lines, six Ar XIV lines, and one Ar XV line. The enhancement is far less than reported in Doschek et al. (2015) but exhibits similar morphology. The argon abundance is close to a photospheric abundance in the enhanced area, and is only marginally an inverse FIP effect. However, as for the published cases, this newly discovered enhancement occurs in association with a sunspot in a small area only a few arcsec in size and therefore we feel it is produced by the same physics that produced the strong inverse FIP case. There is no enhancement effect observed in the normally high-FIP sulfur and oxygen line ratios relative to lines of low-FIP elements available to EIS. Calculations of path lengths in the strongest enhanced area in Doschek et al. (2015) indicate that the argon/calcium enhancement is due to a depletion of low-FIP elements. This work is supported by a NASA Hinode grant.

Sweat pore reactivity as a surrogate measure of sympathetic nervous system activity in trauma-exposed individuals with and without posttraumatic stress disorder.

PubMed

Familoni, Babajide O; Gregor, Kristin L; Dodson, Thomas S; Krzywicki, Alan T; Lowery, Bobby N; Orr, Scott P; Suvak, Michael K; Rasmusson, Ann M

2016-09-01

Stress analysis by FLIR (forward-looking infrared) evaluation (SAFE) has been demonstrated to monitor sweat pore activation (SPA) as a novel surrogate measure of sympathetic nervous system (SNS) activity in a normal population. SNS responses to a series of 15 1-s, 82 dB, white noise bursts were measured by skin conductance (SC) and SAFE monitoring of SPA on the fingers (FiP) and face (FaP) in 10 participants with posttraumatic stress disorder (PTSD) and 16 trauma-exposed participants without PTSD (Mage  = 48.92 ± 12.00 years; 26.9% female). Within participants, SC and FiP responses across trials were strongly correlated (r = .92, p < .001). Correlations between SC and FaP (r = .76, p = .001) and between FiP and FaP (r = .47, p = .005) were smaller. The habituation of SNS responses across the 15 trials was substantial (SC: d = -2.97; FiP: d = -2.34; FaP: d = -1.02). There was a strong correlation between habituation effects for SC and FiP (r = .76, p < .001), but not for SC and FaP (r = .15, p = .45) or FiP and FaP (r = .29, p = .16). Participants with PTSD showed larger SNS responses to the first loud noise than those without PTSD. PTSD reexperiencing symptoms assessed by the PTSD Checklist on the day of testing were associated with the SNS responses to the first loud noise measured by SC (d = 1.19) and FiP (d = .99), but not FaP (d = .10). This study confirms convergence of SAFE and SC as valid measures of SNS activity. SAFE FiP and SC responses were highly predictive of self-rated PTSD reexperiencing symptoms. SAFE may offer an attractive alternative for applications in PTSD and similar populations. © 2016 Society for Psychophysiological Research. This article has been contributed to by US Government employees and their work is in the public domain in the USA.

Novel Regulation of Integrin Trafficking by Rab11-FIP5 in Aggressive Prostate Cancer.

PubMed

Das, Lipsa; Gard, Jaime M C; Prekeris, Rytis; Nagle, Raymond B; Morrissey, Colm; Knudsen, Beatrice S; Miranti, Cindy K; Cress, Anne E

2018-05-14

The laminin-binding integrins, α3β1 and α6β1, are needed for tumor metastasis and their surface expression is regulated by endocytic recycling. β1 integrins share the Rab11 recycling machinery but the trafficking of α3β1 and α6β1 are distinct by an unknown mechanism. Using a mouse PDX tumor model containing human metastatic prostate cancer, Rab11 family interacting protein 5 (Rab11-FIP5) was identified as a lead candidate for α6β1 trafficking. Rab11-FIP5 and its membrane binding domain were required for α6β1 recycling, without affecting the other laminin-binding integrin (i.e., α3β1) or unrelated membrane receptors like CD44, transferrin receptor, or E-cadherin. Depletion of Rab11-FIP5 resulted in the intracellular accumulation of α6β1 in the Rab11 recycling compartment, loss of cell migration on laminin, and an unexpected loss of α6β1 recycling in cell-cell locations. Taken together, these data demonstrate that α6β1 is distinct from α3β1 via Rab11-FIP5 recycling and recycles in an unexpected cell-cell location. Rab11-FIP5 dependent a6b1 integrin recycling may be selectively targeted to limit migration of prostate cancer cells into laminin-rich tissues. Copyright ©2018, American Association for Cancer Research.

Pyschometric testing of the Family Impact of Pain Scale using a sample of families in Australia.

PubMed

West, Caryn; Buettner, Petra; Foster, Kim; Usher, Kim

2012-01-01

To test the psychometric properties of the Family Impact of Pain Scale (FIPS) using a sample of families resident in North Queensland. While pain has a significant effect on the individual, the entire family can be affected when a member of the family has chronic pain. FIPS is the only tool designed to measure the effect of pain on the family. It was originally developed in the UK using a sample of people with dental pain, so to test the psychometric properties of the tool with Australians with chronic pain was essential. DATA SOURCES; Participants (n = 67) completed a survey consisting of four tools: FIPS, the Connor Davidson Resilience Scale (CD-RISC), the Medical Outcomes Study Short Form 36 (SF-36) and the Medical Outcomes Study Social Support Survey (MOS SSS). Psychometric characteristics of FIPS were consistent with previous studies, indicating that the tool can be used reliably to measure the impact of chronic pain on the family in Australia. The FIPS is a reliable tool for predicting the impact of chronic pain on the family and for use with an Australian population. The validation of a tool such as FIPS in an Australian population adds to the current body of knowledge and extends the use of the tool. Such validation supports its reliability and stability across populations and provides Australian healthcare workers with a valid tool to measure the impact of pain on the family.

Rare Variants in RTEL1 Are Associated with Familial Interstitial Pneumonia

PubMed Central

Cogan, Joy D.; Zhao, Min; Mitchell, Daphne B.; Rives, Lynette; Markin, Cheryl; Garnett, Errine T.; Montgomery, Keri H.; Mason, Wendi R.; McKean, David F.; Powers, Julia; Murphy, Elissa; Olson, Lana M.; Choi, Leena; Cheng, Dong-Sheng; Blue, Elizabeth Marchani; Young, Lisa R.; Lancaster, Lisa H.; Steele, Mark P.; Brown, Kevin K.; Schwarz, Marvin I.; Fingerlin, Tasha E.; Schwartz, David A.; Lawson, William E.; Loyd, James E.; Zhao, Zhongming; Phillips, John A.; Blackwell, Timothy S.

2015-01-01

Rationale: Up to 20% of cases of idiopathic interstitial pneumonia cluster in families, comprising the syndrome of familial interstitial pneumonia (FIP); however, the genetic basis of FIP remains uncertain in most families. Objectives: To determine if new disease-causing rare genetic variants could be identified using whole-exome sequencing of affected members from FIP families, providing additional insights into disease pathogenesis. Methods: Affected subjects from 25 kindreds were selected from an ongoing FIP registry for whole-exome sequencing from genomic DNA. Candidate rare variants were confirmed by Sanger sequencing, and cosegregation analysis was performed in families, followed by additional sequencing of affected individuals from another 163 kindreds. Measurements and Main Results: We identified a potentially damaging rare variant in the gene encoding for regulator of telomere elongation helicase 1 (RTEL1) that segregated with disease and was associated with very short telomeres in peripheral blood mononuclear cells in 1 of 25 families in our original whole-exome sequencing cohort. Evaluation of affected individuals in 163 additional kindreds revealed another eight families (4.7%) with heterozygous rare variants in RTEL1 that segregated with clinical FIP. Probands and unaffected carriers of these rare variants had short telomeres (<10% for age) in peripheral blood mononuclear cells and increased T-circle formation, suggesting impaired RTEL1 function. Conclusions: Rare loss-of-function variants in RTEL1 represent a newly defined genetic predisposition for FIP, supporting the importance of telomere-related pathways in pulmonary fibrosis. PMID:25607374

Potent Inhibition of Feline Coronaviruses with Peptidyl Compounds Targeting Coronavirus 3C-like Protease

PubMed Central

Kim, Yunjeong; Mandadapu, Sivakoteswara Rao; Groutas, William C.; Chang, Kyeong-Ok

2012-01-01

Feline coronavirus infection is common among domestic and exotic felid species and usually associated with mild or asymptomatic enteritis; however, feline infectious peritonitis (FIP) is a fatal disease of cats that is caused by systemic infection with a feline infectious peritonitis virus (FIPV), a variant of feline enteric coronavirus (FECV). Currently, there is no specific treatment approved for FIP despite the importance of FIP as the leading infectious cause of death in young cats. During the replication process, coronavirus produces viral polyproteins that are processed into mature proteins by viral proteases, the main protease (3C-like [3CL] protease) and the papain-like protease. Since the cleavages of viral polyproteins are an essential step for virus replication, blockage of viral protease is an attractive target for therapeutic intervention. Previously, we reported the generation of broad-spectrum peptidyl inhibitors against viruses that possess a 3C or 3CL protease. In this study, we further evaluated the antiviral effects of the peptidyl inhibitors against feline coronaviruses, and investigated the interaction between our protease inhibitor and a cathepsin B inhibitor, an entry blocker, against feline coronaviruses in cell culture. Herein we report that our compounds behave as reversible, competitive inhibitors of 3CL protease, potently inhibited the replication of feline coronaviruses (EC50 in a nanomolar range) and, furthermore, the combination of cathepsin B and 3CL protease inhibitors led to a strong synergistic interaction against feline coronaviruses in cell culture systems. PMID:23219425

The Views of Mental Health Manager Towards the Use of a Family Work Model for Psychosis in Guangzhou, China.

PubMed

Dixon, Jeremy; Lei, Jie; Huang, Wanyi; Sin, Jacqueline; Smith, Gina

2018-02-21

Family Interventions in Psychosis (FIP) have been promoted internationally but have been criticised for being based on western cultural models. This paper reports on a focus group study with 10 Integrated Mental Health Service Managers in Guangzhou, China using thematic analysis. Managers believed FIP might benefit families but identified potential difficulties due to (a) families avoiding services due to the 'shame' of mental illness (b) unrealistic expectations of services amongst families (c) deferral to 'key decision-makers' within families when discussing family issues with workers. The findings indicate that FIP work should focus on interaction between carers in the first instance with service users being introduced into sessions at a later date and that more attention needs to be given by the research community to how FIP may be adapted to cultural norms within China.

Risk assessment and source identification of perfluoroalkyl acids in surface and ground water: Spatial distribution around a mega-fluorochemical industrial park, China.

PubMed

Liu, Zhaoyang; Lu, Yonglong; Wang, Tieyu; Wang, Pei; Li, Qifeng; Johnson, Andrew C; Sarvajayakesavalu, Suriyanarayanan; Sweetman, Andrew J

2016-05-01

Perfluoroalkyl acids (PFAAs) can be released to water bodies during manufacturing and application of PFAA-containing products. In this study, the contamination pattern, attenuation dynamics, sources, pathways, and risk zoning of PFAAs in surface and ground water was examined within a 10km radius from a mega-fluorochemical industrial park (FIP). Among 12 detected PFAAs, perfluorooctanoic acid (PFOA) dominated, followed by shorter-chained perfluoroalkyl carboxylic acids (PFCAs). PFAA-containing waste was discharged from the FIP, with levels reaching 1.86mg/L in the nearby rivers flowing to the Bohai sea together with up to 273μg/L in the local groundwater in the catchment. These levels constitute a human health risks for PFOA and other shorter-chained PFCAs within this location. The concentrations of ∑PFAAs in surface water strongly correlated with the local groundwater. The dominant pollution pathways of PFAAs included (i) discharge into surface water then to groundwater through seepage, and (ii) atmospheric deposition from the FIP, followed by infiltration to groundwater. As the distance increased from the source, PFAAs levels in groundwater showed a sharp initial decrease followed by a gentle decline. The contamination signal from the FIP site on PFAAs in groundwater existed within a radius of 4km, and at least 3km from the polluted Dongzhulong River. The major controlling factor in PFAA attenuation processes was likely to be dilution together with dispersion and adsorption to aquifer solids. The relative abundance of PFOA (C8) declined while those of shorter-chained PFCAs (C4-C6) increased during surface water seepage and further dispersion in groundwater. Copyright © 2016 Elsevier Ltd. All rights reserved.

Finnish Prenatal Study of Bipolar Disorders (FIPS-B): overview, design and description of the sample.

PubMed

Chudal, Roshan; Sucksdorff, Dan; Suominen, Auli; Lehti, Venla; Hinkka-Yli-Salomäki, Susanna; Huttunen, Jukka; Ristkari, Terja; Gissler, Mika; McKeague, Ian W; Brown, Alan S; Sourander, Andre

2014-04-01

Bipolar disorders (BPD) are chronic mental illnesses, the development of which involves genetic factors and environmental influences. The aim of this paper is to provide an overall description of the Finnish Prenatal Study of Bipolar Disorders (FIPS-B), including the study design, national registers and linkage of the registers. FIPS-B is a population-based prenatal epidemiological study of BPD with a nested case-control study design using several national registers. The registers used are: the Finnish Medical Birth Register (FMBR), the Finnish Hospital Discharge Register (FHDR), the Population Central Register and the Finnish Maternity Cohort (FMC), which are linked using the unique personal identity code (PIC). FIPS-B includes all children born from January 1, 1983 to December 31, 1998 and diagnosed with BPD in Finland by December 31, 2008. The total number of cases included in the FIPS-B is 1887. The age at first diagnosis ranged from 4 to 25 years. Half (50.4%) of the cases utilized only outpatient services, 12.7% only inpatient services and the rest (36.9%) utilized both services. Offspring of mothers with the lowest educational level had an increased odds of BPD (OR = 1.46, 95% CI 1.13-1.88). The cumulative incidence of BPD in the population aged 25 years or younger was 11.6/10,000 in 2008. FIPS-B has all the strengths of a register-based prenatal epidemiological study, along with the availability of maternal biomarkers, enabling it to examine several prenatal, perinatal and familial risk factors for BPD.

Anomalous abundances of solar energetic particles and coronal gas: Coulomb effects and First Ionization Potential (FIP) ordering

NASA Technical Reports Server (NTRS)

Mullan, D. J.

1985-01-01

The first ionization potential (FIP) ordering of elemental abundances in solar energetic particles and in the corona which can both be explained Coulomb effects is discussed. Solar energetic particles (SEP) and coronal gas have anomalous abundances relative to the photosphere. The anomalies are similar in both cases: which led to the conclusion that SEP acceleration is not selective, but merely preserves the source abundances. It is argued that SEP acceleration can be selective, because identical selectivity operates to determine the coronal abundances. The abundance anomalies are ordered by first ionization potential (FIP).

32 CFR 161.6 - Procedures.

Code of Federal Regulations, 2014 CFR

2014-07-01

... photocopying of DoD ID cards to facilitate medical care processing, check cashing, voting, tax matters... support CAC issuance, which includes fingerprints and facial images specified in FIPS Publication 201-1... the Office of the USD(AT&L), implement the capability to obtain two segmented images (primary and...

ESUSA: US endangered species distribution file

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nagy, J.; Calef, C.E.

1979-10-01

This report describes a file containing distribution data on endangered species of the United States of Federal concern pursuant to the Endangered Species Act of 1973. Included for each species are (a) the common name, (b) the scientific name, (c) the family, (d) the group (mammal, bird, etc.), (e) Fish and Wildlife Service (FWS) listing and recovery priorities, (f) the Federal legal status, (g) the geographic distribution by counties or islands, (h) Federal Register citations and (i) the sources of the information on distribution of the species. Status types are endangered, threatened, proposed, formally under review, candidate, deleted, and rejected.more » Distribution is by Federal Information Processing Standard (FIPS) county code and is of four types: designated critical habitat, present range, potential range, and historic range.« less

NOAA Weather Radio

Science.gov Websites

Information Reception Problems NWR Alarms Automated Voices FIPS Codes NWR - Special Needs SAME USING SAME SAME does not make an audible beep. However, it will display the words "CHECK RECEPTION" until it Reception Problems General Information NWR Alarms FIPS Codes Automated Voices Spanish Voices Public

78 FR 37531 - Agency Information Collection Activities; Comment Request; Annual Performance Reporting (APR...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-21

...; Comment Request; Annual Performance Reporting (APR) System for NIDRR Grantees (RERCs, RRTCS, FIPs, ARRTs... of Collection: Annual Performance Reporting (APR) System for NIDRR Grantees (RERCs, RRTCS, FIPs... requests an extension of the Annual Performance Reporting (APR) System for NIDRR Grantees (RERCs, RRTCS...

In vivo screening of five phytochemicals/extracts and a fungal immunomodulatory protein against colibacillosis in broilers.

PubMed

Peek, H W; Halkes, S B A; Tomassen, M M M; Mes, J J; Landman, W J M

2013-01-01

Five phytochemicals/extracts (an extract from Echinacea purpurea, a β-glucan-rich extract from Shiitake, betaine [Betain™], curcumin from Curcuma longa [turmeric] powder, carvacrol and also a recombinant fungal immunomodulatory protein [FIP] from Ganoderma lucidum) cloned and expressed in Escherichia coli were investigated for their anticolibacillosis potential in three chicken experiments, which were conducted in floor pens. Birds that were inoculated with E. coli intratracheally were treated with the phytochemicals/extracts or the FIP and compared with doxycycline-medicated and non-medicated infected broilers. Non-medicated and non-infected birds were used as negative controls. Mortality, colibacillosis lesions and body weight gains were used as parameters. Considering the sum of dead birds and chickens with generalized colibacillosis per group, there was no significant difference between the positive control groups and birds treated with phytochemicals/extracts or the FIP. In contrast, doxycycline-treated birds showed significantly lower mortality and generalized colibacillosis. Moreover, none of the phytochemicals/extracts and the FIP improved recovery from colibacillosis lesions, while all doxycycline-treated broilers recovered completely. The negative control birds and doxycycline-treated groups consistently showed the highest weight gains. Pulsed-field gel electrophoresis of reisolates showed that they were genetically indistinguishable from the inoculation strain. In conclusion, none of the tested phytochemicals/extracts and the FIP significantly reduced the E. coli-induced mortality and generalized colibacillosis, and nor did they improve recovery from colibacillosis lesions.

Chemical Compositions and Abundance Anomalies in Stellar Coronae ADP 99

NASA Technical Reports Server (NTRS)

Drake, Jeremy; Oliversen, Ronald J. (Technical Monitor)

2003-01-01

Progress has been made using both EUVE (Extreme Ultraviolet Explorer) and ASCA (Advanced Satellite for Cosmology and Astrophysics) data and a new postdoctoral scientist has now been hired. Stars studied to date include YY Gem (dMe binary), xi Boo A (intermediate activity G8 V), xi UMa (more active G quadruple system) HR1099 (K1 IV + G5 V) RS CVn-like, AU Mic (dMe). In addition to a paper that concentrated on abundancies in HR1099, a paper was recently submitted on the coronal abundances of AR(tilde)Lac that revealed an interesting pattern of overabundances of very low FIP elements (Al and Ca) compared to the low FIP elements Si, Mg and Fe. Two papers are nearing completion on methods of analysis and on the abundances in the corona of AU(tilde)Mic. Additionally, two invited conference proceedings papers are being published on this work. The main conclusion of the study to date is that our existing ideas of coronal abundance anomalies need complete revision. The solar-like FIP effect is replaced by a pattern than appears to enhance high FIP elements rather than low FIP elements in very active stars. The archival studies we are undertaking now are revealing some key details of these patterns, and are beginning to map out the anomalies as a function of spectral type, a key goal of this study.

WHO Expert Committee on Specifications for Pharmaceutical Preparations. Fiftieth report.

PubMed

2016-01-01

The Expert Committee on Specifications for Pharmaceutical Preparations works towards clear, independent and practical standards and guidelines for the quality assurance of medicines. Standards are developed by the Committee through worldwide consultation and an international consensus-building process. The following new guidelines were adopted and recommended for use. Good pharmacopoeial practices; FIP-WHO technical guidelines: points to consider in the provision by health-care professionals of children-specific preparations that are not available as authorized products; Guidance on good manufacturing practices for biological products; Guidance on good manufacturing practices: inspection report, including Appendix 1: Model inspection report; Guidance on good data and record management practices; Good trade and distribution practices for starting materials; Guidelines on the conduct of surveys of the quality of medicines; Collaborative procedure between the World Health Organization (WHO) prequalification team and national regulatory authorities in the assessment and accelerated national registration of WHO-prequalified pharmaceutical products and vaccines; Guidance for organizations performing in vivo bioequivalence studies; and World Health Organization (WHO) general guidance on variations to multisource pharmaceutical products.

In vivo screening of four phytochemicals/extracts and a fungal immunomodulatory protein against an Eimeria acervulina infection in broilers.

PubMed

Peek, H W; Halkes, S B A; Mes, J J; Landman, W J M

2013-01-01

Besides the anticoccidial drug resistance problem, increasing consumer concerns about food safety and residues have propelled the quest for alternative prevention and control strategies amongst which phytotherapy has gained appeal due to a renewed interest in natural medicine. The objective was in vivo screening of four phytochemicals/extracts and a fungal immunomodulatory protein (FIP) against an Eimeria acervulina infection in broilers. Four phytochemicals/extracts (extract from Echinacea purpurea, betaine (Betain™), curcumin, carvacrol (two different doses)), and a recombinant FIP from Ganoderma lucidum cloned and expressed in Escherichia coli were investigated for their anticoccidial potential. The experiment was conducted in a battery cage trial with 54 cages of eight birds each. Broilers infected with E. acervulina (a low and high infection dose of 10(4) and 10(5) sporulated oocysts, respectively) and treated with the phytochemicals/extracts or the FIP were compared with broilers treated with the anticoccidial salinomycin sodium (Sacox®) and with an untreated uninfected and an untreated infected control group. Coccidiosis lesion scores, body weight gains and oocyst shedding were used as parameters. The results showed a coccidiosis infection dose effect on the mean coccidiosis lesion scores. The phytochemicals/extracts and the FIP failed to reduce coccidiosis lesion scores and oocyst shedding, while salinomycin efficiently controlled the E. acervulina infection and enabled significantly higher body weight gains. In conclusion, the selected phytochemicals/extracts and the FIP did not reduce the lesions of an experimentally induced E. acervulina infection.

Variability of a Stellar Corona on a Time Scale of Days: Evidence for Abundance Fractionation in an Emerging Coronal Active Region

NASA Technical Reports Server (NTRS)

Nordon, R.; Behar, E.; Drake, S. A.

2013-01-01

Elemental abundance effects in active coronae have eluded our understanding for almost three decades, since the discovery of the first ionization potential (FIP) effect on the sun. The goal of this paper is to monitor the same coronal structures over a time interval of six days and resolve active regions on a stellar corona through rotational modulation. We report on four iso-phase X-ray spectroscopic observations of the RS CVn binary EI Eri with XMM-Newton, carried out approximately every two days, to match the rotation period of EI Eri. We present an analysis of the thermal and chemical structure of the EI Eri corona as it evolves over the six days. Although the corona is rather steady in its temperature distribution, the emission measure and FIP bias both vary and seem to be correlated. An active region, predating the beginning of the campaign, repeatedly enters into our view at the same phase as it rotates from beyond the stellar limb. As a result, the abundances tend slightly, but consistently, to increase for high FIP elements (an inverse FIP effect) with phase. We estimate the abundance increase of high FIP elements in the active region to be of about 75% over the coronal mean. This observed fractionation of elements in an active region on time scales of days provides circumstantial clues regarding the element enrichment mechanism of non-flaring stellar coronae.

Crop bioaccumulation and human exposure of perfluoroalkyl acids through multi-media transport from a mega fluorochemical industrial park, China.

PubMed

Liu, Zhaoyang; Lu, Yonglong; Shi, Yajuan; Wang, Pei; Jones, Kevin; Sweetman, Andrew J; Johnson, Andrew C; Zhang, Meng; Zhou, Yunqiao; Lu, Xiaotian; Su, Chao; Sarvajayakesavaluc, Suriyanarayanan; Khan, Kifayatullah

2017-09-01

Significant quantities of perfluoroalkyl acids (PFAAs) are released to the environment from fluorochemical manufacturing processes through wastewater discharge and air emission in China, which may lead to human exposure and health risks through crop bioaccumulation from PFAAs-contaminated soil and irrigation water. This paper systematically studied the distribution and transport of PFAAs in agricultural soil, irrigation water and precipitation, followed by crop bioaccumulation and finally human exposure of PFAAs within a 10km radius around a mega-fluorochemical industrial park (FIP). Hotspots of contamination by PFAAs were found near the FIP and downstream of the effluent discharge point with the maximum concentrations of 641ng/g in agricultural soil, 480ng/g in wheat grain, 58.8ng/g in maize grain and 4,862ng/L in precipitation. As the distance increased from the FIP, PFAAs concentrations in all media showed a sharp initial decrease followed by a moderate decline. Elevated PFAA concentrations in soil and grains were still present within a radius of 10 km of the FIP. The soil contamination was associated with the presence of PFAAs in irrigation water and precipitation, and perfluorooctanoic acid (PFOA) was the dominant PFAA component in soil. However, due to bioaccumulation preference, short-chain perfluoroalkyl carboxylic acids (PFCAs), especially perfluorobutanoic acid (PFBA), became the major PFAA contaminants in grains of wheat and maize. The bioaccumulation factors (BAFs) for both grains showed a decrease with increasing chain length of PFAAs (approximately 0.5 log decrease per CF 2 group). Compared to maize grain, wheat grain showed higher BAFs, possibly related to its higher protein content. The PFCA (C4-C8) concentrations (on a log 10 basis) in agricultural soil and grain were found to show a linear positive correlation. Local human exposure of PFOA via the consumption of contaminated grains represents a health risk for local residents, especially for toddlers and children. Copyright © 2017 Elsevier Ltd. All rights reserved.

Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor

PubMed Central

Kim, Yunjeong; Liu, Hongwei; Galasiti Kankanamalage, Anushka C.; Weerasekara, Sahani; Hua, Duy H.; Groutas, William C.; Chang, Kyeong-Ok; Pedersen, Niels C.

2016-01-01

Coronaviruses infect animals and humans causing a wide range of diseases. The diversity of coronaviruses in many mammalian species is contributed by relatively high mutation and recombination rates during replication. This dynamic nature of coronaviruses may facilitate cross-species transmission and shifts in tissue or cell tropism in a host, resulting in substantial change in virulence. Feline enteric coronavirus (FECV) causes inapparent or mild enteritis in cats, but a highly fatal disease, called feline infectious peritonitis (FIP), can arise through mutation of FECV to FIP virus (FIPV). The pathogenesis of FIP is intimately associated with immune responses and involves depletion of T cells, features shared by some other coronaviruses like Severe Acute Respiratory Syndrome Coronavirus. The increasing risks of highly virulent coronavirus infections in humans or animals call for effective antiviral drugs, but no such measures are yet available. Previously, we have reported the inhibitors that target 3C-like protease (3CLpro) with broad-spectrum activity against important human and animal coronaviruses. Here, we evaluated the therapeutic efficacy of our 3CLpro inhibitor in laboratory cats with FIP. Experimental FIP is 100% fatal once certain clinical and laboratory signs become apparent. We found that antiviral treatment led to full recovery of cats when treatment was started at a stage of disease that would be otherwise fatal if left untreated. Antiviral treatment was associated with a rapid improvement in fever, ascites, lymphopenia and gross signs of illness and cats returned to normal health within 20 days or less of treatment. Significant reduction in viral titers was also observed in cats. These results indicate that continuous virus replication is required for progression of immune-mediated inflammatory disease of FIP. These findings may provide important insights into devising therapeutic strategies and selection of antiviral compounds for further development for important coronaviruses in animals and humans. PMID:27027316

Dietary patterns associated with overweight and obesity among Brazilian schoolchildren: an approach based on the time-of-day of eating events.

PubMed

Kupek, Emil; Lobo, Adriana S; Leal, Danielle B; Bellisle, France; de Assis, Maria Alice A

2016-12-01

Several studies reported that the timing of eating events has critical implications in the prevention of obesity, but dietary patterns regarding the time-of-day have not been explored in children. The aim of this study was to derive latent food patterns of daily eating events and to examine their associations with overweight/obesity among schoolchildren. A population-based cross-sectional study was conducted with 7-10-year-old Brazilian schoolchildren (n 1232) who completed the Previous Day Food Questionnaire, illustrated with twenty-one foods/beverages in six daily eating events. Latent class analysis was used to derive dietary patterns whose association with child weight status was evaluated by multivariate multinomial regression. Four mutually exclusive latent classes of dietary patterns were identified and labelled according to the time-of-day of eating events and food intake probability (FIP): (A) higher FIP only at lunch; (B) lower FIP at all eating events; (C) higher FIP at lunch, afternoon and evening snacks; (D) lower FIP at breakfast and at evening snack, higher FIP at other meals/snacks. The percentages of children within these classes were 32·3, 48·6, 15·1 and 4·0 %, respectively. After controlling for potential confounders, the mean probabilities of obesity for these classes were 6 % (95 % CI 3·0, 9·0), 13 % (95 % CI 9·0, 17·0), 12 % (95 % CI 6·0, 19) and 11 % (95 % CI 5·0, 17·0), in the same order. In conclusion, the children eating traditional lunch with rice and beans as the main meal of the day (class A) had the lowest obesity risk, thus reinforcing the importance of both the food type and the time-of-day of its intake for weight status.

NASA information resources management handbook

NASA Technical Reports Server (NTRS)

1992-01-01

This National Aeronautics and Space Administration (NASA) Handbook (NHB) implements recent changes to Federal laws and regulations involving the acquisition, management, and use of Federal Information Processing (FIP) resources. This document defines NASA's Information Resources Management (IRM) practices and procedures and is applicable to all NASA personnel. The dynamic nature of the IRM environment requires that the controlling management practices and procedures for an Agency at the leading edge of technology, such as NASA, must be periodically updated to reflect the changes in this environment. This revision has been undertaken to accommodate changes in the technology and the impact of new laws and regulations dealing with IRM. The contents of this document will be subject to a complete review annually to determine its continued applicability to the acquisition, management, and use of FIP resources by NASA. Updates to this document will be accomplished by page changes. This revision cancels NHB 2410.1D, dated April 1985.

40 CFR 52.841 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 3 2012-07-01 2012-07-01 false Interstate pollutant transport provisions; What are the FIP requirements for decreases in emissions of sulfur dioxide? 52.841 Section 52.841... requirements for decreases in emissions of sulfur dioxide? (a) The owner and operator of each source and each...

Prevalence and implications of feline coronavirus infections of captive and free-ranging cheetahs (Acinonyx jubatus).

PubMed Central

Heeney, J L; Evermann, J F; McKeirnan, A J; Marker-Kraus, L; Roelke, M E; Bush, M; Wildt, D E; Meltzer, D G; Colly, L; Lukas, J

1990-01-01

The extent and progression of exposure to feline infectious peritonitis (FIP) virus in the cheetah, Acinonyx jubatus, was monitored by a world-wide serological survey with indirect fluorescent antibody titers to coronavirus. The indirect fluorescent antibody assay was validated by Western blots, which showed that all indirect fluorescent antibody-positive cheetah sera detected both domestic cat and cheetah coronavirus structural proteins. There was a poor correlation between indirect fluorescent antibody results and the presence of coronaviruslike particles in cheetah feces, suggesting that electron microscopic detection of shed particles may not be an easily interpreted diagnostic parameter for FIP disease. Low, but verifiable (by Western blots [immunoblots]) antibody titers against coronavirus were detected in eight free-ranging cheetahs from east Africa as well as from captive cheetahs throughout the world. Of 20 North American cheetah facilities screened, 9 had cheetahs with measurable antibodies to feline coronavirus. Five facilities showed patterns of an ongoing epizootic. Retrospective FIP virus titers of an FIP outbreak in a cheetah-breeding facility in Oregon were monitored over a 5-year period and are interpreted here in terms of clinical disease progression. During that outbreak the morbidity was over 90% and the mortality was 60%, far greater than any previously reported epizootic of FIP in any cat species. Age of infection was a significant risk factor in this epizootic, with infants (less than 3 months old) displaying significantly higher risk for mortality than subadults or adults. Based upon these observations, empirical generalizations are drawn which address epidemiologic concerns for cheetahs in the context of this lethal infectious agent. Images PMID:2157864

76 FR 25177 - Determinations Concerning Need for Error Correction, Partial Approval and Partial Disapproval...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-03

... section 110(c)(1)(B), to promulgate a FIP within 2 years, and, as part of this rulemaking, EPA is... must promulgate a FIP at any time within 2 years after the disapproval, unless the state corrects the... any time within 2 years after the [finding] * * * unless the State corrects the deficiency, and [EPA...

40 CFR 52.38 - What are the requirements of the Federal Implementation Plans (FIPs) under the Transport Rule (TR...

Code of Federal Regulations, 2013 CFR

2013-07-01

... Federal Implementation Plans (FIPs) under the Transport Rule (TR) relating to emissions of nitrogen oxides... emissions of nitrogen oxides? (a)(1) The TR NOX Annual Trading Program provisions set forth in subpart AAAAA... annual emissions of nitrogen oxides (NOX). (2) The provisions of subpart AAAAA of part 97 of this chapter...

40 CFR 52.38 - What are the requirements of the Federal Implementation Plans (FIPs) under the Transport Rule (TR...

Code of Federal Regulations, 2014 CFR

2014-07-01

... Federal Implementation Plans (FIPs) under the Transport Rule (TR) relating to emissions of nitrogen oxides... emissions of nitrogen oxides? (a)(1) The TR NOX Annual Trading Program provisions set forth in subpart AAAAA... annual emissions of nitrogen oxides (NOX). (2) The provisions of subpart AAAAA of part 97 of this chapter...

40 CFR 52.38 - What are the requirements of the Federal Implementation Plans (FIPs) under the Transport Rule (TR...

Code of Federal Regulations, 2012 CFR

2012-07-01

... Federal Implementation Plans (FIPs) under the Transport Rule (TR) relating to emissions of nitrogen oxides... emissions of nitrogen oxides? (a)(1) The TR NOX Annual Trading Program provisions set forth in subpart AAAAA... annual emissions of nitrogen oxides (NOX). (2) The provisions of subpart AAAAA of part 97 of this chapter...

Field Implementation Plan for the In-Situ Bioremediation Treatability Study at the Technical Area-V Groundwater Area of Concern

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Jun

This Field Implementation Plan (FIP) was prepared by Sandia National Laboratories, New Mexico (SNL/NM) and provides instruction on conducting a series of in-situ bioremediation (ISB) tests as described in the Revised Treatability Study Work Plan for In-Situ Bioremediation at the Technical Area-V Groundwater Area of Concern, referred to as the Revised Work Plan in this FIP. The Treatability Study is designed to gravity inject an electron-donor substrate and bioaugmentation bacteria into groundwater via three injection wells to perform bioremediation of the constituents of concern (COCs), nitrate and trichloroethene (TCE), in the regions with the highest concentrations at the Technical Area-Vmore » Groundwater (TAVG) Area of Concern (AOC). The Treatability Study will evaluate the effectiveness of bioremediation solution delivery and COC treatment over time. This FIP is designed for SNL/NM work planning and management. It is not intended to be submitted for regulator’s approval. The technical details presented in this FIP are subject to change based on field conditions, availability of equipment and materials, feasibility, and inputs from Sandia personnel and Aboveground Injection System contractor.« less

The cosmic microwave background radiation power spectrum as a random bit generator for symmetric- and asymmetric-key cryptography.

PubMed

Lee, Jeffrey S; Cleaver, Gerald B

2017-10-01

In this note, the Cosmic Microwave Background (CMB) Radiation is shown to be capable of functioning as a Random Bit Generator, and constitutes an effectively infinite supply of truly random one-time pad values of arbitrary length. It is further argued that the CMB power spectrum potentially conforms to the FIPS 140-2 standard. Additionally, its applicability to the generation of a (n × n) random key matrix for a Vernam cipher is established.

Construction of phosphorylation interaction networks by text mining of full-length articles using the eFIP system.

PubMed

Tudor, Catalina O; Ross, Karen E; Li, Gang; Vijay-Shanker, K; Wu, Cathy H; Arighi, Cecilia N

2015-01-01

Protein phosphorylation is a reversible post-translational modification where a protein kinase adds a phosphate group to a protein, potentially regulating its function, localization and/or activity. Phosphorylation can affect protein-protein interactions (PPIs), abolishing interaction with previous binding partners or enabling new interactions. Extracting phosphorylation information coupled with PPI information from the scientific literature will facilitate the creation of phosphorylation interaction networks of kinases, substrates and interacting partners, toward knowledge discovery of functional outcomes of protein phosphorylation. Increasingly, PPI databases are interested in capturing the phosphorylation state of interacting partners. We have previously developed the eFIP (Extracting Functional Impact of Phosphorylation) text mining system, which identifies phosphorylated proteins and phosphorylation-dependent PPIs. In this work, we present several enhancements for the eFIP system: (i) text mining for full-length articles from the PubMed Central open-access collection; (ii) the integration of the RLIMS-P 2.0 system for the extraction of phosphorylation events with kinase, substrate and site information; (iii) the extension of the PPI module with new trigger words/phrases describing interactions and (iv) the addition of the iSimp tool for sentence simplification to aid in the matching of syntactic patterns. We enhance the website functionality to: (i) support searches based on protein roles (kinases, substrates, interacting partners) or using keywords; (ii) link protein entities to their corresponding UniProt identifiers if mapped and (iii) support visual exploration of phosphorylation interaction networks using Cytoscape. The evaluation of eFIP on full-length articles achieved 92.4% precision, 76.5% recall and 83.7% F-measure on 100 article sections. To demonstrate eFIP for knowledge extraction and discovery, we constructed phosphorylation-dependent interaction networks involving 14-3-3 proteins identified from cancer-related versus diabetes-related articles. Comparison of the phosphorylation interaction network of kinases, phosphoproteins and interactants obtained from eFIP searches, along with enrichment analysis of the protein set, revealed several shared interactions, highlighting common pathways discussed in the context of both diseases. © The Author(s) 2015. Published by Oxford University Press.

Sensitivity and specificity of a real-time reverse transcriptase polymerase chain reaction detecting feline coronavirus mutations in effusion and serum/plasma of cats to diagnose feline infectious peritonitis.

PubMed

Felten, Sandra; Leutenegger, Christian M; Balzer, Hans-Joerg; Pantchev, Nikola; Matiasek, Kaspar; Wess, Gerhard; Egberink, Herman; Hartmann, Katrin

2017-08-02

Feline coronavirus (FCoV) exists as two pathotypes, and FCoV spike gene mutations are considered responsible for the pathotypic switch in feline infectious peritonitis (FIP) pathogenesis. The aim of this study was to evaluate sensitivity and specificity of a real-time reverse transcriptase polymerase chain reaction (RT-PCR) specifically designed to detect FCoV spike gene mutations at two nucleotide positions. It was hypothesized that this test would correctly discriminate feline infectious peritonitis virus (FIPV) and feline enteric coronavirus (FECV). The study included 63 cats with signs consistent with FIP. FIP was confirmed in 38 cats. Twenty-five control cats were definitively diagnosed with a disease other than FIP. Effusion and/or serum/plasma samples were examined by real-time RT-PCR targeting the two FCoV spike gene fusion peptide mutations M1058 L and S1060A using an allelic discrimination approach. Sensitivity, specificity, negative and positive predictive values including 95% confidence intervals (95% CI) were calculated. FIPV was detected in the effusion of 25/59 cats, one of them being a control cat with chronic kidney disease. A mixed population of FIPV/FECV was detected in the effusion of 2/59 cats; all of them had FIP. RT-PCR was negative or the pathotype could not be determined in 34/59 effusion samples. In effusion, sensitivity was 68.6% (95% CI 50.7-83.2), specificity was 95.8% (95% CI 78.9-99.9). No serum/plasma samples were positive for FIPV. Although specificity of the test in effusions was high, one false positive result occurred. The use of serum/plasma cannot be recommended due to a low viral load in blood.

Significance of coronavirus mutants in feces and diseased tissues of cats suffering from feline infectious peritonitis.

PubMed

Pedersen, Niels C; Liu, Hongwei; Dodd, Kimberly A; Pesavento, Patricia A

2009-09-01

The internal FECV→FIPV mutation theory and three of its correlates were tested in four sibs/half-sib kittens, a healthy contact cat, and in four unrelated cats that died of FIP at geographically disparate regions. Coronavirus from feces and extraintestinal FIP lesions from the same cat were always >99% related in accessory and structural gene sequences. SNPs and deletions causing a truncation of the 3c gene product were found in almost all isolates from the diseased tissues of the eight cats suffering from FIP, whereas most, but not all fecal isolates from these same cats had intact 3c genes. Other accessory and structural genes appeared normal in both fecal and lesional viruses. Deliterious mutations in the 3c gene were unique to each cat, indicating that they did not originate in one cat and were subsequently passed horizontally to the others. Compartmentalization of the parental and mutant forms was not absolute; virus of lesional type was sometimes found in feces of affected cats and virus identical to fecal type was occasionally identified in diseased tissues. Although 3c gene mutants in this study were not horizontally transmitted, the parental fecal virus was readily transmitted by contact from a cat that died of FIP to its housemate. There was a high rate of mutability in all structural and accessory genes both within and between cats, leading to minor genetic variants. More than one variant could be identified in both diseased tissues and feces of the same cat. Laboratory cats inoculated with a mixture of two closely related variants from the same FIP cat developed disease from one or the other variant, but not both. Significant genetic drift existed between isolates from geographically distinct regions of the Western US.

Significance of Coronavirus Mutants in Feces and Diseased Tissues of Cats Suffering from Feline Infectious Peritonitis

PubMed Central

Pedersen, Niels C.; Liu, Hongwei; Dodd, Kimberly A.; Pesavento, Patricia A.

2009-01-01

The internal FECV→FIPV mutation theory and three of its correlates were tested in four sibs/half-sib kittens, a healthy contact cat, and in four unrelated cats that died of FIP at geographically disparate regions. Coronavirus from feces and extraintestinal FIP lesions from the same cat were always >99% related in accessory and structural gene sequences. SNPs and deletions causing a truncation of the 3c gene product were found in almost all isolates from the diseased tissues of the eight cats suffering from FIP, whereas most, but not all fecal isolates from these same cats had intact 3c genes. Other accessory and structural genes appeared normal in both fecal and lesional viruses. Deliterious mutations in the 3c gene were unique to each cat, indicating that they did not originate in one cat and were subsequently passed horizontally to the others. Compartmentalization of the parental and mutant forms was not absolute; virus of lesional type was sometimes found in feces of affected cats and virus identical to fecal type was occasionally identified in diseased tissues. Although 3c gene mutants in this study were not horizontally transmitted, the parental fecal virus was readily transmitted by contact from a cat that died of FIP to its housemate. There was a high rate of mutability in all structural and accessory genes both within and between cats, leading to minor genetic variants. More than one variant could be identified in both diseased tissues and feces of the same cat. Laboratory cats inoculated with a mixture of two closely related variants from the same FIP cat developed disease from one or the other variant, but not both. Significant genetic drift existed between isolates from geographically distinct regions of the Western US. PMID:21994544

40 CFR Appendix A to Subpart A of... - Tables

Code of Federal Regulations, 2011 CFR

2011-07-01

... precursor of PM2.5. Table 2a to Appendix A of Subpart A—Data Elements for Reporting on Emissions From Point Sources, Where Required by 40 CFR 51.30 Data elements Every-yearreporting Three-yearreporting (1... phone number ✓ ✓ (6) FIPS code ✓ ✓ (7) Facility ID codes ✓ ✓ (8) Unit ID code ✓ ✓ (9) Process ID code...

The Role of the Rab Coupling Protein in ErbB2-Driven Mammary Tumorigenesis and Metastasis

DTIC Science & Technology

2014-10-01

Coupling Protein/Rab11FIP1/RCP, Epithelial Mesenchymal Transition , Cell junctions , Cell Proliferation, Senescence. 16. SECURITY CLASSIFICATION OF: 17...Tyrosine Kinase, Her/ErbB2 signaling, Rab Coupling Protein/Rab11FIP1/RCP, Epithelial Mesenchymal Transition , Cell junctions , Cell Proliferation...lines included RCP condition to internalization and detection of E-cadherin, a well-known adherent junction and epithelial mesenchymal transition

Coronal Elemental Abundances in Solar Emerging Flux Regions

NASA Astrophysics Data System (ADS)

Baker, Deborah; Brooks, David H.; van Driel-Gesztelyi, Lidia; James, Alexander W.; Démoulin, Pascal; Long, David M.; Warren, Harry P.; Williams, David R.

2018-03-01

The chemical composition of solar and stellar atmospheres differs from the composition of their photospheres. Abundances of elements with low first ionization potential (FIP) are enhanced in the corona relative to high-FIP elements with respect to the photosphere. This is known as the FIP effect and it is important for understanding the flow of mass and energy through solar and stellar atmospheres. We used spectroscopic observations from the Extreme-ultraviolet Imaging Spectrometer on board the Hinode observatory to investigate the spatial distribution and temporal evolution of coronal plasma composition within solar emerging flux regions inside a coronal hole. Plasma evolved to values exceeding those of the quiet-Sun corona during the emergence/early-decay phase at a similar rate for two orders of magnitude in magnetic flux, a rate comparable to that observed in large active regions (ARs) containing an order of magnitude more flux. During the late-decay phase, the rate of change was significantly faster than what is observed in large, decaying ARs. Our results suggest that the rate of increase during the emergence/early-decay phase is linked to the fractionation mechanism that leads to the FIP effect, whereas the rate of decrease during the later decay phase depends on the rate of reconnection with the surrounding magnetic field and its plasma composition.

p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200.

PubMed

Morselli, Eugenia; Shen, Shensi; Ruckenstuhl, Christoph; Bauer, Maria Anna; Mariño, Guillermo; Galluzzi, Lorenzo; Criollo, Alfredo; Michaud, Mickael; Maiuri, Maria Chiara; Chano, Tokuhiro; Madeo, Frank; Kroemer, Guido

2011-08-15

The tumor suppressor protein p53 tonically suppresses autophagy when it is present in the cytoplasm. This effect is phylogenetically conserved from mammals to nematodes, and human p53 can inhibit autophagy in yeast, as we show here. Bioinformatic investigations of the p53 interactome in relationship to the autophagy-relevant protein network underscored the possible relevance of a direct molecular interaction between p53 and the mammalian ortholog of the essential yeast autophagy protein Atg17, namely RB1-inducible coiled-coil protein 1 (RB1CC1), also called FAK family kinase-interacting protein of 200 KDa (FIP200). Mutational analyses revealed that a single point mutation in p53 (K382R) abolished its capacity to inhibit autophagy upon transfection into p53-deficient human colon cancer or yeast cells. In conditions in which wild-type p53 co-immunoprecipitated with RB1CC1/FIP200, p53 (K382R) failed to do so, underscoring the importance of the physical interaction between these proteins for the control of autophagy. In conclusion, p53 regulates autophagy through a direct molecular interaction with RB1CC1/FIP200, a protein that is essential for the very apical step of autophagy initiation.

VARIATIONS IN SOLAR WIND FRACTIONATION AS SEEN BY ACE/SWICS AND THE IMPLICATIONS FOR GENESIS MISSION RESULTS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pilleri, P.; Wiens, R. C.; Reisenfeld, D. B.

We use Advanced Composition Explorer (ACE)/Solar Wind Ion Composition Spectrometer (SWICS) elemental composition data to compare the variations in solar wind (SW) fractionation as measured by SWICS during the last solar maximum (1999–2001), the solar minimum (2006–2009), and the period in which the Genesis spacecraft was collecting SW (late 2001—early 2004). We differentiate our analysis in terms of SW regimes (i.e., originating from interstream or coronal hole flows, or coronal mass ejecta). Abundances are normalized to the low-first ionization potential (low-FIP) ion magnesium to uncover correlations that are not apparent when normalizing to high-FIP ions. We find that relative tomore » magnesium, the other low-FIP elements are measurably fractionated, but the degree of fractionation does not vary significantly over the solar cycle. For the high-FIP ions, variation in fractionation over the solar cycle is significant: greatest for Ne/Mg and C/Mg, less so for O/Mg, and the least for He/Mg. When abundance ratios are examined as a function of SW speed, we find a strong correlation, with the remarkable observation that the degree of fractionation follows a mass-dependent trend. We discuss the implications for correcting the Genesis sample return results to photospheric abundances.« less

Home produced eggs: An important pathway of human exposure to perfluorobutanoic acid (PFBA) and perfluorooctanoic acid (PFOA) around a fluorochemical industrial park in China.

PubMed

Su, Hongqiao; Shi, Yajuan; Lu, Yonglong; Wang, Pei; Zhang, Meng; Sweetman, Andrew; Jones, Kevin; Johnson, Andrew

2017-04-01

Dietary intake is considered to be a major pathway of human exposure to perfluoroalkyl acids (PFAAs). Chicken egg is an important contributor to the Chinese diet. In the present study, PFAAs in home produced eggs (HPEs) and commercially produced eggs (CPEs) surrounding a fluorochemical industrial park (FIP) in China were investigated. PFAAs in HPEs decreased with increasing distance from the FIP. HPEs were much more contaminated than CPEs, with PFAAs in CPEs comparable to or lower than those in HPEs from 20km away from the FIP. PFOA concentrations in HPEs were higher than the levels of PFOA in eggs from other studies reported so far. For the first time, PFBA was reported in eggs and detected in all egg samples. PFOA and PFBA were the predominant forms in HPEs, while PFOA, PFBA and PFOS dominated in CPEs. For PFOA, estimated daily intakes (EDI) were 233ng/kg·bw/day for adults and 657ng/kg·bw/day for children who consume HPEs at households about 2km away from the FIP. The EDI of PFOA for children via HPEs exceeded the reference dose value (333ng/kg·bw/day) proposed by the Environmental Working Group. Copyright © 2017 Elsevier Ltd. All rights reserved.

WHO Expert Committee on Specifications for Pharmaceutical Preparations.

PubMed

2011-01-01

The Expert Committee on Specifications for Pharmaceutical Preparations works towards clear, independent and practical standards and guidelines for the quality assurance of medicines. Standards are developed by the Committee through worldwide consultation and an international consensus-building process. The following new guidelines were adopted and recommended for use: procedure for adoption of International Chemical Reference Substances; WHO good practices for pharmaceutical microbiology laboratories; good manufacturing practices: main principles for pharmaceutical products; good manufacturing practices for blood establishments (jointly with the Expert Committee on Biological Standardization); guidelines on good manufacturing practices for heating, ventilation and air-conditioning systems for non-sterile pharmaceutical dosage forms; good manufacturing practices for sterile pharmaceutical products; guidelines on transfer of technology in pharmaceutical manufacturing; good pharmacy practice: standards for quality of pharmacy services (joint FIP/WHO); model guidance for the storage and transport of time- and temperature-sensitive pharmaceutical products (jointly with the Expert Committee on Biological Standardization); procedure for prequalification of pharmaceutical products; guide on submission of documentation for prequalification of innovator finished pharmaceutical products approved by stringent regulatory authorities; prequalification of quality control laboratories: procedure for assessing the acceptability, in principle, of quality control laboratories for use by United Nations agencies; guidelines for preparing a laboratory information file; guidelines for drafting a site master file; guidelines on submission of documentation for a multisource (generic) finished product: general format: preparation of product dossiers in common technical document format.

WIFIP: a web-based user interface for automated synchrotron beamlines.

PubMed

Sallaz-Damaz, Yoann; Ferrer, Jean Luc

2017-09-01

The beamline control software, through the associated graphical user interface (GUI), is the user access point to the experiment, interacting with synchrotron beamline components and providing automated routines. FIP, the French beamline for the Investigation of Proteins, is a highly automatized macromolecular crystallography (MX) beamline at the European Synchrotron Radiation Facility. On such a beamline, a significant number of users choose to control their experiment remotely. This is often performed with a limited bandwidth and from a large choice of computers and operating systems. Furthermore, this has to be possible in a rapidly evolving experimental environment, where new developments have to be easily integrated. To face these challenges, a light, platform-independent, control software and associated GUI are required. Here, WIFIP, a web-based user interface developed at FIP, is described. Further than being the present FIP control interface, WIFIP is also a proof of concept for future MX control software.

IRDS prototyping with applications to the representation of EA/RA models

NASA Technical Reports Server (NTRS)

Lekkos, Anthony A.; Greenwood, Bruce

1988-01-01

The requirements and system overview for the Information Resources Dictionary System (IRDS) are described. A formal design specification for a scaled down IRDS implementation compatible with the proposed FIPS IRDS standard is contained. The major design objectives for this IRDS will include a menu driven user interface, implementation of basic IRDS operations, and PC compatibility. The IRDS was implemented using Smalltalk/5 object oriented programming system and an ATT 6300 personal computer running under MS-DOS 3.1. The difficulties encountered in using Smalltalk are discussed.

National Underground Mines Inventory

DTIC Science & Technology

1983-10-01

system is well designed to minimize water accumulation on the drift levels. In many areas, sufficient water has accumulated to make the use of boots a...four characters designate Field office. 17-18 State Code Pic 99 FIPS code for state in which minets located. 19-21 County Code Plc 999 FIPS code for... Designate a general product class based onSIC code. 28-29 Nine Type Plc 99 Natal/Nonmetal mine type code. Based on subunit operations code and canvass code

A cubic map chaos criterion theorem with applications in generalized synchronization based pseudorandom number generator and image encryption.

PubMed

Yang, Xiuping; Min, Lequan; Wang, Xue

2015-05-01

This paper sets up a chaos criterion theorem on a kind of cubic polynomial discrete maps. Using this theorem, Zhou-Song's chaos criterion theorem on quadratic polynomial discrete maps and generalized synchronization (GS) theorem construct an eight-dimensional chaotic GS system. Numerical simulations have been carried out to verify the effectiveness of theoretical results. The chaotic GS system is used to design a chaos-based pseudorandom number generator (CPRNG). Using FIPS 140-2 test suit/Generalized FIPS 140-2, test suit tests the randomness of two 1000 key streams consisting of 20 000 bits generated by the CPRNG, respectively. The results show that there are 99.9%/98.5% key streams to have passed the FIPS 140-2 test suit/Generalized FIPS 140-2 test. Numerical simulations show that the different keystreams have an average 50.001% same codes. The key space of the CPRNG is larger than 2(1345). As an application of the CPRNG, this study gives an image encryption example. Experimental results show that the linear coefficients between the plaintext and the ciphertext and the decrypted ciphertexts via the 100 key streams with perturbed keys are less than 0.00428. The result suggests that the decrypted texts via the keystreams generated via perturbed keys of the CPRNG are almost completely independent on the original image text, and brute attacks are needed to break the cryptographic system.

A cubic map chaos criterion theorem with applications in generalized synchronization based pseudorandom number generator and image encryption

NASA Astrophysics Data System (ADS)

Yang, Xiuping; Min, Lequan; Wang, Xue

2015-05-01

This paper sets up a chaos criterion theorem on a kind of cubic polynomial discrete maps. Using this theorem, Zhou-Song's chaos criterion theorem on quadratic polynomial discrete maps and generalized synchronization (GS) theorem construct an eight-dimensional chaotic GS system. Numerical simulations have been carried out to verify the effectiveness of theoretical results. The chaotic GS system is used to design a chaos-based pseudorandom number generator (CPRNG). Using FIPS 140-2 test suit/Generalized FIPS 140-2, test suit tests the randomness of two 1000 key streams consisting of 20 000 bits generated by the CPRNG, respectively. The results show that there are 99.9%/98.5% key streams to have passed the FIPS 140-2 test suit/Generalized FIPS 140-2 test. Numerical simulations show that the different keystreams have an average 50.001% same codes. The key space of the CPRNG is larger than 21345. As an application of the CPRNG, this study gives an image encryption example. Experimental results show that the linear coefficients between the plaintext and the ciphertext and the decrypted ciphertexts via the 100 key streams with perturbed keys are less than 0.00428. The result suggests that the decrypted texts via the keystreams generated via perturbed keys of the CPRNG are almost completely independent on the original image text, and brute attacks are needed to break the cryptographic system.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Xiuping, E-mail: yangxiuping-1990@163.com; Min, Lequan, E-mail: minlequan@sina.com; Wang, Xue, E-mail: wangxue-20130818@163.com

This paper sets up a chaos criterion theorem on a kind of cubic polynomial discrete maps. Using this theorem, Zhou-Song's chaos criterion theorem on quadratic polynomial discrete maps and generalized synchronization (GS) theorem construct an eight-dimensional chaotic GS system. Numerical simulations have been carried out to verify the effectiveness of theoretical results. The chaotic GS system is used to design a chaos-based pseudorandom number generator (CPRNG). Using FIPS 140-2 test suit/Generalized FIPS 140-2, test suit tests the randomness of two 1000 key streams consisting of 20 000 bits generated by the CPRNG, respectively. The results show that there are 99.9%/98.5% keymore » streams to have passed the FIPS 140-2 test suit/Generalized FIPS 140-2 test. Numerical simulations show that the different keystreams have an average 50.001% same codes. The key space of the CPRNG is larger than 2{sup 1345}. As an application of the CPRNG, this study gives an image encryption example. Experimental results show that the linear coefficients between the plaintext and the ciphertext and the decrypted ciphertexts via the 100 key streams with perturbed keys are less than 0.00428. The result suggests that the decrypted texts via the keystreams generated via perturbed keys of the CPRNG are almost completely independent on the original image text, and brute attacks are needed to break the cryptographic system.« less

Development of a mouse-feline chimeric antibody against feline tumor necrosis factor-alpha.

PubMed

Doki, Tomoyoshi; Takano, Tomomi; Hohdatsu, Tsutomu

2016-10-01

Feline infectious peritonitis (FIP) is a fatal inflammatory disease caused by FIP virus infection. Feline tumor necrosis factor (fTNF)-alpha is closely involved in the aggravation of FIP pathology. We previously described the preparation of neutralizing mouse anti-fTNF-alpha monoclonal antibody (mAb 2-4) and clarified its role in the clinical condition of cats with FIP using in vitro systems. However, administration of mouse mAb 2-4 to cat may lead to a production of feline anti-mouse antibodies. In the present study, we prepared a mouse-feline chimeric mAb (chimeric mAb 2-4) by fusing the variable region of mouse mAb 2-4 to the constant region of feline antibody. The chimeric mAb 2-4 was confirmed to have fTNF-alpha neutralization activity. Purified mouse mAb 2-4 and chimeric mAb 2-4 were repeatedly administered to cats, and the changes in the ability to induce feline anti-mouse antibody response were investigated. In the serum of cats treated with mouse mAb 2-4, feline anti-mouse antibody production was induced, and the fTNF-alpha neutralization effect of mouse mAb 2-4 was reduced. In contrast, in cats treated with chimeric mAb 2-4, the feline anti-mouse antibody response was decreased compared to that of mouse mAb 2-4-treated cats.

Autophagy-related polymorphisms predict hypertension in patients with metastatic colorectal cancer treated with FOLFIRI and bevacizumab: Results from TRIBE and FIRE-3 trials.

PubMed

Berger, Martin D; Yamauchi, Shinichi; Cao, Shu; Hanna, Diana L; Sunakawa, Yu; Schirripa, Marta; Matsusaka, Satoshi; Yang, Dongyun; Groshen, Susan; Zhang, Wu; Ning, Yan; Okazaki, Satoshi; Miyamoto, Yuji; Suenaga, Mitsukuni; Lonardi, Sara; Cremolini, Chiara; Falcone, Alfredo; Heinemann, Volker; Loupakis, Fotios; Stintzing, Sebastian; Lenz, Heinz-Josef

2017-05-01

The most frequent bevacizumab-related side-effects are hypertension, proteinuria, bleeding and thromboembolism. To date, there is no biomarker that predicts anti-VEGF-associated toxicity. As autophagy inhibits angiogenesis, we hypothesised that single-nucleotide polymorphisms (SNPs) within autophagy-related genes may predict bevacizumab-mediated toxicity in patients with metastatic colorectal cancer (mCRC). Patients with mCRC treated with first-line FOLFIRI and bevacizumab in two phase III randomised trials, namely the TRIBE trial (n = 219, discovery cohort) and the FIRE-3 trial (n = 234, validation cohort) were included in this study. Patients receiving treatment with FOLFIRI and cetuximab (FIRE-3, n = 204) served as a negative control. 12 SNPs in eight autophagy-related genes (ATG3/5/8/13, beclin 1, FIP200, unc-51-like kinase 1, UVRAG) were analysed by PCR-based direct sequencing. The FIP200 rs1129660 variant showed significant associations with hypertension in the TRIBE cohort. Patients harbouring any G allele of the FIP200 rs1129660 SNP showed a significantly lower rate of grade 2-3 hypertension compared with the A/A genotype (3% versus 15%, odds ratio [OR] 0.17; 95% confidence interval [CI], 0.02-0.73; P = 0.009). Similarly, G allele carriers of the FIP200 rs1129660 SNP were less likely to develop grade 2-3 hypertension than patients with an A/A genotype in the FIRE-3 validation cohort (9% versus 20%, OR 0.43; 95% CI, 0.14-1.11; P = 0.077), whereas this association could not be observed in the control cohort (12% versus 9%, OR 1.40; 95% CI, 0.45-4.04; P = 0.60). This is the first report demonstrating that polymorphisms in the autophagy-related FIP200 gene may predict hypertension in patients with mCRC treated with FOLFIRI and bevacizumab. Copyright © 2017 Elsevier Ltd. All rights reserved.

OSI in the NASA science internet: An analysis

NASA Technical Reports Server (NTRS)

Nitzan, Rebecca

1990-01-01

The Open Systems Interconnection (OSI) protocol suite is a result of a world-wide effort to develop international standards for networking. OSI is formalized through the International Organization for Standardization (ISO) and the International Electrotechnical Commission (IEC). The goal of OSI is to provide interoperability between network products without relying on one particular vendor, and to do so on a multinational basis. The National Institute for Standards and Technology (NIST) has developed a Government OSI Profile (GOSIP) that specified a subset of the OSI protocols as a Federal Information Processing Standard (FIPS 146). GOSIP compatibility has been adopted as the direction for all U.S. government networks. OSI is extremely diverse, and therefore adherence to a profile will facilitate interoperability within OSI networks. All major computer vendors have indicated current or future support of GOSIP-compliant OSI protocols in their products. The NASA Science Internet (NSI) is an operational network, serving user requirements under NASA's Office of Space Science and Applications. NSI consists of the Space Physics Analysis Network (SPAN) that uses the DECnet protocols and the NASA Science Network (NSN) that uses TCP/IP protocols. The NSI Project Office is currently working on an OSI integration analysis and strategy. A long-term goal is to integrate SPAN and NSN into one unified network service, using a full OSI protocol suite, which will support the OSSA user community.

Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer | Office of Cancer Genomics

Cancer.gov

Recent evidence has established a role for the small GTPase RAB25, as well as related effector proteins, in enacting both pro-oncogenic and anti-oncogenic phenotypes in specific cellular contexts. Here we report the development of all-hydrocarbon stabilized peptides derived from the RAB-binding FIP-family of proteins to target RAB25. Relative to unmodified peptides, optimized stapled peptides exhibit increased structural stability, binding affinity, cell permeability, and inhibition of RAB25:FIP complex formation.

The Genesis Mission: Solar Wind Conditions, and Implications for the FIP Fractionation of the Solar Wind.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reisenfeld, D. B.; Wiens, R. C.; Barraclough, B. L.

2005-01-01

The NASA Genesis mission collected solar wind on ultrapure materials between November 30, 2001 and April 1, 2004. The samples were returned to Earth September 8, 2004. Despite the hard landing that resulted from a failure of the avionics to deploy the parachute, many samples were returned in a condition that will permit analyses. Sample analyses of these samples should give a far better understanding of the solar elemental and isotopic composition (Burnett et al. 2003). Further, the photospheric composition is thought to be representative of the solar nebula, so that the Genesis mission will provide a new baseline formore » the average solar nebula composition with which to compare present-day compositions of planets, meteorites, and asteroids. Sample analysis is currently underway. The Genesis samples must be placed in the context of the solar and solar wind conditions under which they were collected. Solar wind is fractionated from the photosphere by the forces that accelerate the ions off of the Sun. This fractionation appears to be ordered by the first ionization potential (FIP) of the elements, with the tendency for low-FIP elements to be over-abundant in the solar wind relative to the photosphere, and high-FIP elements to be under-abundant (e.g. Geiss, 1982; von Steiger et al., 2000). In addition, the extent of elemental fractionation differs across different solarwind regimes. Therefore, Genesis collected solar wind samples sorted into three regimes: 'fast wind' or 'coronal hole' (CH), 'slow wind' or 'interstream' (IS), and 'coronal mass ejection' (CME). To carry this out, plasma ion and electron spectrometers (Barraclough et al., 2003) continuously monitored the solar wind proton density, velocity, temperature, the alpha/proton ratio, and angular distribution of suprathermal electrons, and those parameters were in turn used in a rule-based algorithm that assigned the most probable solar wind regime (Neugebauer et al., 2003). At any given time, only one of three regime-specific collectors (CH, IS, or CME) was exposed to the solar wind. Here we report on the regime-specific solar wind conditions from in-situ instruments over the course of the collection period. Further, we use composition data from the SWICS (Solar Wind Ion Composition Spectrometer) instrument on ACE (McComas et al., 1998) to examine the FIP fractionation between solar wind regimes, and make a preliminary comparison of these to the FIP analysis of Ulysses/SWICS composition data (von Steiger et al. 2000). Our elemental fractionation study includes a reevaluation of the Ulysses FIP analysis in light of newly reported photospheric abundance data (Asplund, Grevesse & Sauval, 2005). The new abundance data indicate a metallicity (Z/X) for the Sun almost a factor of two lower than that reported in the widely used compilation of Anders & Grevesse (1989). The new photospheric abundances suggest a lower degree of solar wind fractionation than previously reported by von Steiger et al. (2000) for the first Ulysses polar orbit (1991-1998).« less

Elemental and charge state composition of the fast solar wind observed with SMS instruments on WIND

NASA Technical Reports Server (NTRS)

Gloeckler, G.; Galvin, A. B.; Ipavich, F. M.; Hamilton, D. C.; Bochsler, P.; Geiss, J.; Fisk, L. A.; Wilken, B.

1995-01-01

The elemental composition and charge state distributions of heavy ions of the solar wind provide essential information about: (1) atom-ion separation processes in the solar atmosphere leading to the 'FIP effect' (the overabundance of low First Ionization potential (FIP) elements in the solar wind compared to the photosphere); and (2) coronal temperature profiles, as well as mechanisms which heat the corona and accelerate the solar wind. This information is required for solar wind acceleration models. The SWICS instrument on Ulysses measures for all solar wind flow conditions the relative abundance of about 8 elements and 20 charge states of the solar wind. Furthermore, the Ulysses high-latitude orbit provides an unprecedented look at the solar wind from the polar coronal holes near solar minimum conditions. The MASS instrument on the WIND spacecraft is a high-mass resolution solar wind ion mass spectrometer that will provide routinely not only the abundances and charge state of all elements easily measured with SWICS, but also of N, Mg, S. The MASS sensor was fully operational at the end of 1994 and has sampled the in-ecliptic solar wind composition in both the slow and the corotating fast streams. This unique combination of SWICS on Ulysses and MASS on WIND allows us to view for the first time the solar wind from two regions of the large coronal hole. Observations with SWICS in the coronal hole wind: (1) indicate that the FIP effect is small; and (2) allow us determine the altitude of the maximum in the electron temperature profile, and indicate a maximum temperature of approximately 1.5 MK. New results from the SMS instruments on Wind will be compared with results from SWICS on Ulysses.

Resolving the xi Boo Binary with Chandra, and Revealing the Spectral Type Dependence of the Coronal "Fip Effect"

NASA Technical Reports Server (NTRS)

Wood, Brian E.; Linsky, Jeffrey L.

2010-01-01

On 2008 May 2, Chandra observed the X-ray spectrum of xi Boo (G8 V+K4 V), resolving the binary for the first time in X-rays and allowing the coronae of the two stars to be studied separately. With the contributions of ξ Boo A and B to the system's total X-ray emission now observationally established (88.5% and 11.5% respectively), consideration of mass loss measurements for GK dwarfs of various activity levels (including one for xi Boo) leads to the surprising conclusion that xi Boo B may dominate the wind from the binary, with xi Boo A's wind being very weak despite its active corona. Emission measure (EM) distributions and coronal abundances are computed for both stars and compared with Chandra measurements of other moderately active stars with G8-K5 spectral types, all of which exhibit a narrow peak in EM near log T = 6.6, indicating that the coronal heating process in these stars has a strong preference for this temperature. As is the case for the Sun and many other stars, our sample of stars shows coronal abundance anomalies dependent on the first ionization potential (FIP) of the element. We see no dependence of the degree of FIP effect on activity, but there is a dependence on spectral type, a correlation that becomes more convincing when moderately active main-sequence stars with a broader range of spectral types are considered. This clear dependence of coronal abundances on spectral type weakens if the stellar sample is allowed to be contaminated by evolved stars, interacting binaries or extremely active stars with logLX 29, explaining why this correlation has not been recognized in the past.

RESOLVING THE {xi} BOO BINARY WITH CHANDRA, AND REVEALING THE SPECTRAL TYPE DEPENDENCE OF THE CORONAL 'FIP EFFECT'

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wood, Brian E.; Linsky, Jeffrey L., E-mail: brian.wood@nrl.navy.mi, E-mail: jlinsky@jila.colorado.ed

On 2008 May 2, Chandra observed the X-ray spectrum of {xi} Boo (G8 V+K4 V), resolving the binary for the first time in X-rays and allowing the coronae of the two stars to be studied separately. With the contributions of {xi} Boo A and B to the system's total X-ray emission now observationally established (88.5% and 11.5%, respectively), consideration of mass loss measurements for GK dwarfs of various activity levels (including one for {xi} Boo) leads to the surprising conclusion that {xi} Boo B may dominate the wind from the binary, with {xi} Boo A's wind being very weak despitemore » its active corona. Emission measure (EM) distributions and coronal abundances are computed for both stars and compared with Chandra measurements of other moderately active stars with G8-K5 spectral types, all of which exhibit a narrow peak in EM near log T = 6.6, indicating that the coronal heating process in these stars has a strong preference for this temperature. As is the case for the Sun and many other stars, our sample of stars shows coronal abundance anomalies dependent on the first ionization potential (FIP) of the element. We see no dependence of the degree of 'FIP effect' on activity, but there is a dependence on spectral type, a correlation that becomes more convincing when moderately active main-sequence stars with a broader range of spectral types are considered. This clear dependence of coronal abundances on spectral type weakens if the stellar sample is allowed to be contaminated by evolved stars, interacting binaries, or extremely active stars with log L{sub X} >29, explaining why this correlation has not been recognized in the past.« less

The functional interplay of Rab11, FIP3 and Rho proteins on the endosomal recycling pathway controls cell shape and symmetry.

PubMed

Bouchet, Jérôme; McCaffrey, Mary W; Graziani, Andrea; Alcover, Andrés

2018-07-04

Several families of small GTPases regulate a variety of fundamental cellular processes, encompassing growth factor signal transduction, vesicular trafficking and control of the cytoskeleton. Frequently, their action is hierarchical and complementary, but much of the detail of their functional interactions remains to be clarified. It is well established that Rab family members regulate a variety of intracellular vesicle trafficking pathways. Moreover, Rho family GTPases are pivotal for the control of the actin and microtubule cytoskeleton. However, the interplay between these 2 types of GTPases has been rarely reported. We discuss here our recent findings showing that Rab11, a key regulator of endosomal recycling, and Rac1, a central actin cytoskeleton regulator involved in lamellipodium formation and cell migration, interplay on endosomes through the Rab11 effector FIP3. In the context of the rapidly reactive T lymphocytes, Rab11-Rac1 endosomal functional interplay is important to control cell shape changes and cell symmetry during lymphocyte spreading and immunological synapse formation and ultimately modulate T cell activation.

Utilizing remote sensing of thematic mapper data to improve our understanding of estuarine processes and their influence on the productivity of estuarine-dependent fisheries

NASA Technical Reports Server (NTRS)

Browder, Joan A.; May, L. Nelson, Jr.; Rosenthal, Alan; Baumann, Robert H.; Gosselink, James G.

1987-01-01

A stochastic spatial computer model addressing coastal resource problems in Lousiana is being refined and validated using thematic mapper (TM) imagery. The TM images of brackish marsh sites were processed and data were tabulated on spatial parameters from TM images of the salt marsh sites. The Fisheries Image Processing Systems (FIPS) was used to analyze the TM scene. Activities were concentrated on improving the structure of the model and developing a structure and methodology for calibrating the model with spatial-pattern data from the TM imagery.

HIV-1 Envelope Glycoprotein Trafficking through the Endosomal Recycling Compartment Is Required for Particle Incorporation.

PubMed

Kirschman, Junghwa; Qi, Mingli; Ding, Lingmei; Hammonds, Jason; Dienger-Stambaugh, Krista; Wang, Jaang-Jiun; Lapierre, Lynne A; Goldenring, James R; Spearman, Paul

2018-03-01

The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) encodes specific trafficking signals within its long cytoplasmic tail (CT) that regulate incorporation into HIV-1 particles. Rab11-family interacting protein 1C (FIP1C) and Rab14 are host trafficking factors required for Env particle incorporation, suggesting that Env undergoes sorting from the endosomal recycling compartment (ERC) to the site of particle assembly on the plasma membrane. We disrupted outward sorting from the ERC by expressing a C-terminal fragment of FIP1C (FIP1C 560-649 ) and examined the consequences on Env trafficking and incorporation into particles. FIP1C 560-649 reduced cell surface levels of Env and prevented its incorporation into HIV-1 particles. Remarkably, Env was trapped in an exaggerated perinuclear ERC in a CT-dependent manner. Mutation of either the Yxxϕ endocytic motif or the YW 795 motif in the CT prevented Env trapping in the ERC and restored incorporation into particles. In contrast, simian immunodeficiency virus SIVmac239 Env was not retained in the ERC, while substitution of the HIV-1 CT for the SIV CT resulted in SIV Env retention in this compartment. These results provide the first direct evidence that Env traffics through the ERC and support a model whereby HIV-1 Env is specifically targeted to the ERC prior to FIP1C- and CT-dependent outward sorting to the particle assembly site on the plasma membrane. IMPORTANCE The HIV envelope protein is an essential component of the viral particle. While many aspects of envelope protein structure and function have been established, the pathway it follows in the cell prior to reaching the site of particle assembly is not well understood. The envelope protein has a very long cytoplasmic tail that interacts with the host cell trafficking machinery. Here, we utilized a truncated form of the trafficking adaptor FIP1C protein to arrest the intracellular transport of the envelope protein, demonstrating that it becomes trapped inside the cell within the endosomal recycling compartment. Intracellular trapping resulted in a loss of envelope protein on released particles and a corresponding loss of infectivity. Mutations of specific trafficking motifs in the envelope protein tail prevented its trapping in the recycling compartment. These results establish that trafficking to the endosomal recycling compartment is an essential step in HIV envelope protein particle incorporation. Copyright © 2018 American Society for Microbiology.

76 FR 31263 - Approval and Promulgation of Implementation Plans; State of California; Interstate Transport of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-31

...EPA is proposing a limited approval and limited disapproval of a State Implementation Plan (``SIP'') revision submitted by the State of California on November 17, 2007, for the purpose of addressing the ``transport SIP'' provisions of Clean Air Act (``CAA'') section 110(a)(2)(D)(i) for the 1997 8-hour ozone National Ambient Air Quality Standards (NAAQS or standards) and the 1997 fine particulate matter (``PM2.5'') NAAQS. Section 110(a)(2)(D)(i) of the CAA requires that each SIP contain adequate provisions to prohibit emissions that adversely affect air quality in other States through interstate transport. EPA is proposing a limited approval and limited disapproval of California's SIP revision for the 1997 8-hour ozone and 1997 PM2.5 NAAQS with respect to the requirement in CAA section 110(a)(2)(D)(i)(II) that each SIP contain adequate measures prohibiting emissions of air pollutants in amounts which will interfere with other States' measures required under title I, part C of the CAA to prevent significant deterioration of air quality. Specifically, EPA is proposing to approve California's SIP revision with respect to those Districts in California that implement SIP-approved permit programs meeting the approval criteria under CAA section 110(a)(2)(D)(i), as discussed in this proposal. EPA is simultaneously proposing to disapprove California's SIP revision with respect to those Districts in California that do not implement SIP-approved permit programs meeting these approval criteria. For any District for which we finalize a disapproval, EPA intends to simultaneously promulgate a limited Federal Implementation Plan (``FIP''), as discussed in this proposal, unless the relevant area is already subject to a FIP.

Non-thermal Processes in the Formation of Mercury's Tenuous Exosphere

NASA Astrophysics Data System (ADS)

Schaible, M. J.; Bennett, C.; Jones, B. M.; Orlando, T. M.

2017-12-01

Recent observations from the MESSENGER spacecraft orbiting Mercury have established that a quasi-trapped population of ions and electrons with 1-10 keV energy exists at a distance of about 1.5 RM (RM is Mercury's radius) around much of the planet. Recent observations from the Fast Imaging Plasma Spectrometer (FIPS), taken < 400 km from the surface, have shown a plasma cusp with energetic heavy ions (i.e. Na+ and O+ groups). The sources of these ions are not clear. A newly developed global kinetic transport model suggests that electron-stimulated desorption (ESD), and possibly light ion stimulated desorption (ISD), can directly yield ions that can be transported and dynamically accelerated to the plasma cusp regions observed by FIPS. Neutrals desorbed from the surface by ESD, ISD, photon-stimulated desorption (PSD) and meteorite impact may also be photoionized and transported/injected into the cusp region. Though the relative importance of these mechanisms in the formation of Mercury's tenuous atmosphere and the subsequent effects on the exosphere/magnetosphere dynamics are not known, it is likely that all of these contribute significantly. The goals of this work are to measure desorption cross-sections and ejection velocities for Na+, O+, and water group ions under relevant electron and ion bombardment energies. This program utilizes state-of-the art surface science capabilities to probe the role of ESD and ISD as a source of ions and neutrals present in the exosphere of Mercury. The experimental chamber is equipped with a dosing system, a cryogenic cooled temperature controlled sample holder, as well as pulsed ion and electron sources. The ESD and ISD ion yields and velocity measurements are obtained directly by sampling with a time-of-flight mass spectrometer. The measured ESD ion yields from adsorbate covered Mercury surface analogs such as the sulfur bearing minerals MgS, Na2S and K2S are low. Additionally, ISD experiments using incident protons also yielded low ion signals. These results implicate PSD and neutral desorption as dominant processes. The information obtained from these experiments can be directly incorporated into model simulations for comparison with data recently obtained by the FIPS instrument.

ANOMALOUS RELATIVE AR/CA CORONAL ABUNDANCES OBSERVED BY THE HINODE/EUV IMAGING SPECTROMETER NEAR SUNSPOTS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Doschek, G. A.; Warren, H. P.; Feldman, U.

2015-07-20

In determining the element abundance of argon (a high first ionization potential; FIP element) relative to calcium (a low FIP element) in flares, unexpectedly high intensities of two Ar xiv lines (194.40, 187.96 Å) relative to a Ca xiv line (193.87 Å) intensity were found in small (a few arcseconds) regions near sunspots in flare spectra recorded by the Extreme-ultraviolet Imaging Spectrometer on the Hinode spacecraft. In the most extreme case the Ar xiv line intensity relative to the Ca xiv intensity was 7 times the value expected from the photospheric abundance ratio, which is about 30 times the abundancemore » of argon relative to calcium in active regions, i.e., the measured Ar/Ca abundance ratio is about 10 instead of 0.37 as in active regions. The Ar xiv and Ca xiv lines are formed near 3.4 MK and have very similar contribution functions. This is the first observation of the inverse FIP effect in the Sun. Other regions show increases of 2–3 over photospheric abundances, or just photospheric abundances. This phenomenon appears to occur rarely and only over small areas of flares away from the regions containing multi-million degree plasma, but more work is needed to quantify the occurrences and their locations. In the bright hot regions of flares the Ar/Ca abundance ratio is coronal, i.e., the same as in active regions. In this Letter we show three examples of the inverse FIP effect.« less

THE MYSTERIOUS CASE OF THE SOLAR ARGON ABUNDANCE NEAR SUNSPOTS IN FLARES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Doschek, G. A.; Warren, H. P.

Recently we discussed an enhancement of the abundance of Ar xiv relative to Ca xiv near a sunspot during a flare, observed in spectra recorded by the Extreme-ultraviolet Imaging Spectrometer (EIS) on the Hinode spacecraft. The observed Ar xiv/Ca xiv ratio yields an argon/calcium abundance ratio seven times greater than expected from the photospheric abundance. Such a large abundance anomaly is unprecedented in the solar atmosphere. We interpreted this result as being due to an inverse first ionization potential (FIP) effect. In the published work, two lines of Ar xiv were observed, and one line was tentatively identified as anmore » Ar xi line. In this paper, we report observing a similar enhancement in a full-CCD EIS flare spectrum in 13 argon lines that lie within the EIS wavelength ranges. The observed lines include two Ar xi lines, four Ar xiii lines, six Ar xiv lines, and one Ar xv line. The enhancement is far less than reported in Doschek et al. but exhibits similar morphology. The argon abundance is close to a photospheric abundance in the enhanced area, and the abundance could be photospheric. This enhancement occurs in association with a sunspot in a small area only a few arcseconds (1″ = about 700 km) in size. There is no enhancement effect observed in the normally high-FIP sulfur and oxygen line ratios relative to lines of low-FIP elements available to EIS. Calculations of path lengths in the strongest enhanced area in Doschek et al. indicate a depletion of low-FIP elements.« less

Computational Insights into the Molecular Mechanism of the High Immunomodulatory Activity of LZ-8 Protein Isolated from the Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes).

PubMed

Bao, Da-Peng; Bai, Rui; Gao, Ying-Nv; Wu, Ying-Ying; Wang, Ying

2018-01-01

Ling zhi-8 (LZ-8) is the first fungal immunomodulatory protein (FIP) isolated from the lingzhi or reishi medicinal mushroom, Ganoderma lucidum. LZ-8 effectively induces interleukin 2 expression and secretion by forming a stable homodimer, and it is regarded as a good candidate to become a new therapeutic agent and/or functional food supplement. However, the molecular mechanism by which LZ-8 dimerization influences the regulation of interleukin 2 is not clear. In this study we performed structure-based multiple alignment of LZ-8 and an FIP from Volvariella volvacea, compared the electrostatic potential of their protein surfaces, and developed a model summarizing the unique electrostatic interaction in LZ-8 dimerization. In addition, further electrostatic potential and virtual amino acid mutation analyses suggested that L10, W12, and D45 are the key amino acid residues responsible for the protein's high immunomodulatory activity. These findings may provide useful insights into the design and construction of a new FIP mutant for use in treating and preventing autoimmune diseases.

Global Practices of Interprofessional Education (IPE) and Relevant International Activities.

PubMed

Arakawa, Naoko

2017-01-01

Activities related to interprofessional education (IPE) vary between countries according to local and national health needs and systems. The International Pharmaceutical Federation (FIP) Education Initiative endeavors to provide a global vision in IPE by the sharing of experiences and gathering of evidence collaboratively to facilitate country-level initiatives. The purpose of this paper is to contribute to the further development of IPE activities in pharmacy in Japan through sharing global perspectives and activities related to IPE. FIP Education Initiative published the Interprofessional Education in a Pharmacy Context: Global Report in September 2015, which marked a milestone in the growing recognition of IPE in pharmacy globally. The paper shared global and regional perspectives and experiences in IPE in pharmacy, both from the report and FIP activities. This paper can be seen as a snapshot of IPE-related international activities, which enables gaps and challenges in implementing IPE activities in Japan to be identified. This paper provides an opportunity to explore global trends and initiatives regarding IPE, and to consider how to form and implement IPE specifically based on Japanese health needs and systems.

Common Badging and Access Control System (CBACS)

NASA Technical Reports Server (NTRS)

Dischinger, Portia

2005-01-01

This slide presentation presents NASA's Common Badging and Access Control System. NASA began a Smart Card implementation in January 2004. Following site surveys, it was determined that NASA's badging and access control systems required upgrades to common infrastructure in order to provide flexibly, usability, and return on investment prior to a smart card implantation. Common Badging and Access Control System (CBACS) provides the common infrastructure from which FIPS-201 compliant processes, systems, and credentials can be developed and used.

Analysis of Protein Phosphorylation and Its Functional Impact on Protein-Protein Interactions via Text Mining of the Scientific Literature.

PubMed

Wang, Qinghua; Ross, Karen E; Huang, Hongzhan; Ren, Jia; Li, Gang; Vijay-Shanker, K; Wu, Cathy H; Arighi, Cecilia N

2017-01-01

Post-translational modifications (PTMs) are one of the main contributors to the diversity of proteoforms in the proteomic landscape. In particular, protein phosphorylation represents an essential regulatory mechanism that plays a role in many biological processes. Protein kinases, the enzymes catalyzing this reaction, are key participants in metabolic and signaling pathways. Their activation or inactivation dictate downstream events: what substrates are modified and their subsequent impact (e.g., activation state, localization, protein-protein interactions (PPIs)). The biomedical literature continues to be the main source of evidence for experimental information about protein phosphorylation. Automatic methods to bring together phosphorylation events and phosphorylation-dependent PPIs can help to summarize the current knowledge and to expose hidden connections. In this chapter, we demonstrate two text mining tools, RLIMS-P and eFIP, for the retrieval and extraction of kinase-substrate-site data and phosphorylation-dependent PPIs from the literature. These tools offer several advantages over a literature search in PubMed as their results are specific for phosphorylation. RLIMS-P and eFIP results can be sorted, organized, and viewed in multiple ways to answer relevant biological questions, and the protein mentions are linked to UniProt identifiers.

Simultaneous fast measurement of circuit dynamics at multiple sites across the mammalian brain

PubMed Central

Kim, Christina K; Yang, Samuel J; Pichamoorthy, Nandini; Young, Noah P; Kauvar, Isaac; Jennings, Joshua H; Lerner, Talia N; Berndt, Andre; Lee, Soo Yeun; Ramakrishnan, Charu; Davidson, Thomas J; Inoue, Masatoshi; Bito, Haruhiko; Deisseroth, Karl

2017-01-01

Real-time activity measurements from multiple specific cell populations and projections are likely to be important for understanding the brain as a dynamical system. Here we developed frame-projected independent-fiber photometry (FIP), which we used to record fluorescence activity signals from many brain regions simultaneously in freely behaving mice. We explored the versatility of the FIP microscope by quantifying real-time activity relationships among many brain regions during social behavior, simultaneously recording activity along multiple axonal pathways during sensory experience, performing simultaneous two-color activity recording, and applying optical perturbation tuned to elicit dynamics that match naturally occurring patterns observed during behavior. PMID:26878381

Severe Prolonged Cough as Presenting Manifestation of FIP1L1-PDGFRA+ Chronic Eosinophilic Leukaemia: A Widely Ignored Association.

PubMed

Roufosse, Florence; Heimann, Pierre; Lambert, Frédéric; Sidon, Pierre; Bron, Dominique; Cottin, Vincent; Cordier, Jean-François

2016-01-01

Chronic eosinophilic leukaemia associated with the FIP1L1-PDGFRA fusion gene (F/P+ CEL) is a rare cause of marked persistent hypereosinophilia, arising almost exclusively in male patients. Clinical presentations are heterogeneous with a higher incidence of eosinophil-mediated cardiomyopathy than in other hypereosinophilic syndrome variants. Features of chronic myeloproliferative disease are often present, including splenomegaly and elevated serum vitamin B12 levels. The diagnosis is made by fluorescence in situ hybridization (FISH) showing the deletion of the CHIC2 locus and/or RT-PCR showing the FIP1L1-PDGFRA fusion transcript. Treatment with imatinib mesylate, a tyrosine kinase inhibitor, results in rapid and complete resolution of hypereosinophilia and associated symptoms, except for those related to sub-endocardial fibrosis that may be irreversible. We report the case of a male patient in whom isolated intractable cough remained the only clinical manifestation of F/P+ CEL for 4 years. Furthermore, eosinophil autofluorescence, an as yet unreported artefact in this setting, precluded the detection of the CHIC2 deletion and further delayed diagnosis, underlining that both FISH and RT-PCR should be performed when this disease is suspected. © 2016 S. Karger AG, Basel.

Solar Flare Abundances of Potassium, Argon, and Sulphur

NASA Technical Reports Server (NTRS)

Oegerle, William (Technical Monitor); Phillips, K. J. H.; Sylwester, J.; Sylwester, B.; Landi, E.

2003-01-01

The absolute coronal abundances of potassium has been determined for the first time from X-ray solar flare line and continuous spectra together with absolute and relative abundances of Ar and S. Potassium is of importance in the continuing debate concerning the nature of the coronal/photospheric element abundance ratios which are widely considered to depend on first ionization potential since it has the lowest FIP of any common element in the Sun. The measurements were obtained with the RESIK crystal spectrometer on the Coronas-F spacecraft. A differential emission measure DEM = const. x exp (-(beta)T(sub e) was found to be the most consistent with the data out of three models considered. We find that the coronal ratio [K/H] = 3.7 x 10(exp - 7), a factor 3 times photospheric, in agreement with other observations using line-to-line ratios. Our measured value for the coronal ratio [Ar/H] = 1.5 x 10(exp -6) is significantly less than photospheric, indicating that there is a slight depletion of this high-FIP element in the corona. For S (an intermediate-FIP element) we obtained [S/H] = 2.2 x 10(exp - 5), approximately the same as in previous work.

Does UV CETI Suffer from the MAD Syndrome?

NASA Technical Reports Server (NTRS)

Drake, Jeremy

2000-01-01

Data have been reduced and partially analyzed and models have been fitted. ASCA data indicate a metal-poor corona, with metals down by a factor of 3 or more relative to the photospheric values. EUVE data show a FIP effect, which is expected if the metals are enhanced rather than depleted. An absolute measure of the metal abundance has not yet been performed for the EUVE data. Either the FIP effect is in operation in the presence of a global depletion of metals, or the ASCA analysis is giving the wrong answer. The latter could be the case if the plasma models applied are incomplete. Further investigation into this is warranted prior to publication.

PHOTOSPHERIC ABUNDANCES OF POLAR JETS ON THE SUN OBSERVED BY HINODE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Kyoung-Sun; Brooks, David H.; Imada, Shinsuke, E-mail: lksun@solar.isas.jaxa.jp

2015-08-20

Many jets are detected at X-ray wavelengths in the Sun's polar regions, and the ejected plasma along the jets has been suggested to contribute mass to the fast solar wind. From in situ measurements in the magnetosphere, it has been found that the fast solar wind has photospheric abundances while the slow solar wind has coronal abundances. Therefore, we investigated the abundances of polar jets to determine whether they are the same as that of the fast solar wind. For this study, we selected 22 jets in the polar region observed by Hinode/EUV Imaging Spectroscopy (EIS) and X-ray Telescope (XRT)more » simultaneously on 2007 November 1–3. We calculated the First Ionization Potential (FIP) bias factor from the ratio of the intensity between high (S) and low (Si, Fe) FIP elements using the EIS spectra. The values of the FIP bias factors for the polar jets are around 0.7–1.9, and 75% of the values are in the range of 0.7–1.5, which indicates that they have photospheric abundances similar to the fast solar wind. The results are consistent with the reconnection jet model where photospheric plasma emerges and is rapidly ejected into the fast wind.« less

77 FR 23987 - Approval and Promulgation of Implementation Plans; State of Montana; State Implementation Plan...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-20

...The Environmental Protection Agency (EPA) is proposing a Federal Implementation Plan (FIP) to address regional haze in the State of Montana. EPA developed this proposal in response to the State's decision in 2006 to not submit a regional haze State Implementation Plan (SIP) revision. EPA is proposing to determine that the FIP satisfies requirements of the Clean Air Act (CAA or ``the Act'') that require states, or EPA in promulgating a FIP, to assure reasonable progress towards the national goal of preventing any future and remedying any existing man-made impairment of visibility in mandatory Class I areas. In addition, EPA is also proposing to approve a revision to the Montana SIP submitted by the State of Montana through the Montana Department of Environmental Quality on February 17, 2012. The State's submittal contains revisions to the Montana Visibility Plan that includes amendments to the ``Smoke Management'' section, which adds a reference to Best Available Control Technology (BACT) as the visibility control measure for open burning as currently administered through the State's air quality permit program. This change was made to meet the requirements of the Regional Haze Rule. EPA will act on the remaining revisions in the State's submittal in a future action.

Chemical Compositions and Abundance Anomalies in Stellar Coronae ADP 99

NASA Technical Reports Server (NTRS)

Oliversen, Ronald J. (Technical Monitor); Drake, Jeremy

2004-01-01

New atomic data for tackling some of our spectra have been investigated by co-I Laming (NRL), including the effects of recombination on spectral line fluxes that are not included in, for example, the CHIANTI database models. Promising new progress has been made with modelling some of the recent abundance anomaly results in terms of Alven wave-driven separation of neutrals and ions in the upper chromosphere. The problems that existing models have is that they cannot simultaneously explain the low-FIP enhanced solar-like coronae and the high-FIP rich active coronae of RS CVn-like stars. The Alven wave model shows promise with both of these scenarios, with the fractionation or suppression of low-FIP ions depending on the characteristics of the chromosphere. This work is currently in the writing up stage. In summary, the work to-date is making good progress in mapping abundance anomalies as a function of spectral type and activity level. We are also making good progress with modelling that we will be able to test with our observational results. With one more year of effort, we'anticipate that the bulk of the work described above can be published, together with outstanding key studies on anomalies among the different active binaries.

Identification of Ponatinib as a potent inhibitor of growth, migration and activation of neoplastic eosinophils carrying FIP1L1-PDGFRA

PubMed Central

Sadovnik, Irina; Lierman, Els; Peter, Barbara; Herrmann, Harald; Suppan, Verena; Stefanzl, Gabriele; Haas, Oskar; Lion, Thomas; Pickl, Winfried; Cools, Jan; Vandenberghe, Peter; Valent, Peter

2015-01-01

In chronic eosinophilic leukemia (CEL), the transforming oncoprotein FIP1L1-PDGFRA is a major target of therapy. In most patients, the tyrosine kinase inhibitor (TKI) imatinib induces complete remission. For patients who are intolerant or resistant, novel TKI have been proposed. We examined the in vitro effects of 14 kinase blockers on growth and function of EOL-1 cells, a FIP1L1-PDGFRA+ eosinophil cell line. Major growth-inhibitory effects were seen with all PDGFR-blocking agents, with IC50 values in the low nM-range: ponatinib: 0.1-0.2 nM, sorafenib: 0.1-0.2 nM, masitinib: 0.2-0.5 nM, nilotinib: 0.2-1 nM, dasatinib: 0.5-2 nM, sunitinib: 1-2 nM, midostaurin: 5-10 nM. These drugs were also found to block activation of PDGFR-downstream signaling molecules, including Akt, S6, and STAT5 in EOL-1 cells. All effective TKI produced apoptosis in EOL-1 cells as determined by microscopy, Annexin-V/PI, and caspase-3-staining. In addition, PDGFR-targeting TKI were found to inhibit cytokine-induced migration of EOL-1 cells. In all bioassays employed, ponatinib was found to be the most potent compound in EOL-1 cells. In addition, ponatinib was found to downregulate expression of the activation-linked surface antigen CD63 on EOL-1 cells, and to suppress growth of primary neoplastic eosinophils. We also examined drug effects on Ba/F3 cells expressing two clinically relevant imatinib-resistant mutant-forms of FIP1L1-PDGFRA, namely T674I and D842V. Strong inhibitory effects on both mutants were only seen with ponatinib. In summary, novel PDGFR-targeting TKI may be alternative agents for the treatment of patients with imatinib-resistant CEL. Although several different PDGFR-targeting agents are effective, the most potent drug appears to be ponatinib. PMID:24407160

Ependymin, a brain extracellular glycoprotein, and CNS plasticity.

PubMed

Shashoua, V E

1991-01-01

Ependymin, a glycoprotein of the brain ECF, has been implicated in the neurochemistry of memory and neuronal regeneration. Three behavioral experiments (swimming with a float, avoidance conditioning, and classical conditioning) in the goldfish and one in the mouse (T-maze learning) indicate that ependymin has a role in the synaptic changes that take place in the consolidation step of memory formation and the activity-dependent phase of sharpening of goldfish retinotectal connections during neuronal regeneration. The ECF concentration of the protein was found to decrease after the goldfish learned to associate a light stimulus (CS) with the subsequent arrival of a shock (US): paired CS-US gave changes whereas an unpaired presentation of CS-US gave no changes relative to the unstimulated controls. Ependymin is present in ECF as a mixture of three disulfide-linked dimers of two acidic (alpha and beta) polypeptide chains (37 kDa and 31 kDa). Upon removal of its N-linked glycan fragment by N-glycosidase F, the beta chain yields gamma-ependymin (26 kDa). Determinations of the amino acid sequence of gamma-ependymin indicate that it is a unique protein with no long sequence homologies to any known polypeptide. There are, however, small segments (5-7 amino acids long) with homologies to fibronectin, laminin, and tubulin. Ependymin has the capacity to polymerize into FIP (after activation by phosphorylation) in response to events that deplete ECF calcium. FIP is insoluble in 2% SDS in 6 M urea, 10 mM Ca2+Ac2, 100% acetic acid, chloroform/methanol (2/1), saturated KCNS, and even 100% trifluoroacetic acid. FIP was found to be present in goldfish brain and to be formed as a labeled product in vivo. Ependymin's FIP-forming property was used to propose a molecular hypothesis for generating synaptic changes in response to local extracellular depletions of calcium at sites of "associating inputs." The model assumes that, following NMDA receptor stimulation, the translocated PKC that is generated activates extracellular ependymin by converting it to its phosphorylated form using presynaptically released ATP. The hypothesis was tested in studies of LTP of rat hippocampal slices at CA1. After LTP, new sites that stained with antisera to ependymin, visible at 100x, were obtained in its potentiated radiatum in the CA1 region but not in the unpotentiated CA3. Electron microscopic studies showed that the horseradish peroxidase reaction product obtained was localized at synaptic clefts and postsynaptic regions. The results suggest that FIP may be formed at extracellular and postsynaptic loci where multiple associating inputs interact at CA1.

Re-engineering the mission life cycle with ABC and IDEF

NASA Technical Reports Server (NTRS)

Mandl, Daniel; Rackley, Michael; Karlin, Jay

1994-01-01

The theory behind re-engineering a business process is to remove the non-value added activities thereby lowering the process cost. In order to achieve this, one must be able to identify where the non-value added elements are located which is not a trivial task. This is because the non-value added elements are often hidden in the form of overhead and/or pooled resources. In order to be able to isolate these non-value added processes from among the other processes, one must first decompose the overall top level process into lower layers of sub-processes. In addition, costing data must be assigned to each sub-process along with the value the sub-process adds towards the final product. IDEF0 is a Federal Information Processing Standard (FIPS) process-modeling tool that allows for this functional decomposition through structured analysis. In addition, it illustrates the relationship of the process and the value added to the product or service. The value added portion is further defined in IDEF1X which is an entity relationship diagramming tool. The entity relationship model is the blueprint of the product as it moves along the 'assembly line' and therefore relates all of the parts to each other and the final product. It also relates the parts to the tools that produce the product and all of the paper work that is used in their acquisition. The use of IDEF therefore facilitates the use of Activity Based Costing (ABC). ABC is an essential method in a high variety, product-customizing environment, to facilitate rapid response to externally caused change. This paper describes the work being done in the Mission Operations Division to re-engineer the development and operation life cycle of Mission Operations Centers using these tools.

Plasma Distribution in Mercury's Magnetosphere Derived from MESSENGER Magnetometer and Fast Imaging Plasma Spectrometer Observations

NASA Technical Reports Server (NTRS)

Korth, Haje; Anderson, Brian J.; Gershman, Daniel J.; Raines, Jim M.; Slavin, James A.; Zurbuchen, Thomas H.; Solomon, Sean C.; McNutt, Ralph L.

2014-01-01

We assess the statistical spatial distribution of plasma in Mercury's magnetosphere from observations of magnetic pressure deficits and plasma characteristics by the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft. The statistical distributions of proton flux and pressure were derived from 10months of Fast Imaging Plasma Spectrometer (FIPS) observations obtained during the orbital phase of the MESSENGER mission. The Magnetometer-derived pressure distributions compare favorably with those deduced from the FIPS observations at locations where depressions in the magnetic field associated with the presence of enhanced plasma pressures are discernible in the Magnetometer data. The magnitudes of the magnetic pressure deficit and the plasma pressure agree on average, although the two measures of plasma pressure may deviate for individual events by as much as a factor of approximately 3. The FIPS distributions provide better statistics in regions where the plasma is more tenuous and reveal an enhanced plasma population near the magnetopause flanks resulting from direct entry of magnetosheath plasma into the low-latitude boundary layer of the magnetosphere. The plasma observations also exhibit a pronounced north-south asymmetry on the nightside, with markedly lower fluxes at low altitudes in the northern hemisphere than at higher altitudes in the south on the same field line. This asymmetry is consistent with particle loss to the southern hemisphere surface during bounce motion in Mercury's offset dipole magnetic field.

Approved Air Quality Implementation Plans in Region 10

EPA Pesticide Factsheets

Landing page for information about EPA-approved air quality State Implementation Plans (SIPs), Tribal Implementation Plans (TIPs), and Federal Implementation Plans (FIPs) in Alaska, Idaho, Oregon, Washington.

County-level Estimates for Carbon Distribution in U.S. Croplands, 1990-2005

DOE Data Explorer

West, Tristram O. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

2008-01-01

Net Primary Productivity (NPP) for croplands can be estimated using a statistical method that includes factors for dry weight, harvest indices, and root:shoot ratios multiplied by yield data from the National Agricultural Statistics Service (NASS). This method has been documented and published by Prince et al. (2001), Hicke and Lobell (2004), and Hicke et al. (2004). We expanded this method by including factors for more crops and by using an estimated carbon content of 0.45 for agricultural crops to estimate (a) total net carbon uptake, (b) carbon in aboveground biomass, (c) carbon in belowground biomass, (d) carbon harvested and transported off site, and (e) the amount of carbon remaining on the surface following harvest. These five variables are included with their respective Federal Information Processing Standards (FIPS) codes for all counties in the contiguous U.S. from 1990-2005. A mean harvest efficiency of 0.95 was assumed across all crops. Total cropland NPP for the U.S. ranges from 378-527 Tg C yr^-1 within years 1990-2005, and total carbon harvested and removed ranges from 161-228 Tg C yr^-1 within years 1990-2005.

Crossed fused renal ectopia in a Persian cat

PubMed Central

Seo, Sang-Hyuk; Lee, Hyun-A; Suh, Sang-Il; Choi, Ran; Park, In-Chul; Hyun, Changbaig

2017-01-01

Case summary This report describes a rare case of crossed fused renal ectopia (CFRE) in a cat. A mature intact male Persian cat presented with bloody nasal discharge and ascites. Diagnostic studies revealed an ectopic left kidney fused with an orthotopic right kidney and a concurrent feline infectious peritonitis (FIP) infection. The FIP was responsible for clinical signs in this cat, while clinical signs associated with CFRE were not obvious. Despite receiving intensive treatment, the cat died. A post-mortem examination was not performed because the owners declined approval. Relevance and novel information To the best of our knowledge, this is the first report of L-shaped CFRE in a cat. In addition, this report describes the CT features of L-shaped CFRE in a cat. PMID:28491454

All-trans-retinoic acid enhances apoptosis induction by tyrosine kinase inhibitors in the eosinophilic leukemia-derived EoL-1 cell line.

PubMed

Robert, Carine; Apàti, Agota; Chomienne, Christine; Papp, Béla

2008-02-01

Imatinib and retinoids induce apoptosis in FIP1L1/PDGFRalpha-positive EoL-1 leukemia cells. Although imatinib induces complete remission in most FIP1L1/PDGFRalpha-positive patients, response to imatinib is sometimes suboptimal. In order to enhance the potency of the molecularly targeted therapy of eosinophilic leukemia, we investigated the effect of retinoids combined with tyrosine kinase inhibitors on EoL-1 cells. We demonstrate that retinoids combined with tyrosine kinase inhibitors lead to enhanced apoptosis induction in EoL-1 cells. Our results suggest that tyrosine kinase inhibitors combined with retinoids may constitute a valuable therapeutic approach for sensitive neoplasias that may display enhanced anti-leukemic potency when compared to single drug treatments.

Camera calibration based on the back projection process

NASA Astrophysics Data System (ADS)

Gu, Feifei; Zhao, Hong; Ma, Yueyang; Bu, Penghui

2015-12-01

Camera calibration plays a crucial role in 3D measurement tasks of machine vision. In typical calibration processes, camera parameters are iteratively optimized in the forward imaging process (FIP). However, the results can only guarantee the minimum of 2D projection errors on the image plane, but not the minimum of 3D reconstruction errors. In this paper, we propose a universal method for camera calibration, which uses the back projection process (BPP). In our method, a forward projection model is used to obtain initial intrinsic and extrinsic parameters with a popular planar checkerboard pattern. Then, the extracted image points are projected back into 3D space and compared with the ideal point coordinates. Finally, the estimation of the camera parameters is refined by a non-linear function minimization process. The proposed method can obtain a more accurate calibration result, which is more physically useful. Simulation and practical data are given to demonstrate the accuracy of the proposed method.

Familial Pulmonary Fibrosis

MedlinePlus

... called Familial Pulmonary Fibrosis (FPF) or Familial Interstitial Pneumonia (FIP). The most common definition of FPF is two or more primary biological family members (parent, child, or sibling) with the diagnosis of IPF or ...

First Identification of Foreshock Plasma Populations at Mercury

NASA Astrophysics Data System (ADS)

Glass, A. N.; Tracy, P. J.; Raines, J. M.

2018-05-01

Observations of foreshock populations at Mercury are presented for the first time utilizing measurements from the Fast Imaging Plasma Spectrometer (FIPS) aboard MESSENGER, and plausible energization mechanisms are suggested and evaluated.

Determination of State Budgets for the Final Ozone Supplemental of the Transport Rule TSD

EPA Pesticide Factsheets

In this final rulemaking, EPA finalizes Federal Implementation Plans (FIPs) to address significant contribution to nonattainment and interference with maintenance in Iowa, Michigan, Missouri, Oklahoma, and Wisconsin.

Approved Air Quality Implementation Plans in The Virgin Islands

EPA Pesticide Factsheets

This site contains information about air quality regulations called State Implementation Plans (SIPs), Federal Implementation Plans (FIPs), and Tribal Implementation Plans (TIPs) approved by EPA within the U.S. Virgin Islands.

Dynamic heterogeneity in the folding/unfolding transitions of FiP35

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mori, Toshifumi, E-mail: mori@ims.ac.jp; Saito, Shinji, E-mail: shinji@ims.ac.jp

Molecular dynamics simulations have become an important tool in studying protein dynamics over the last few decades. Atomistic simulations on the order of micro- to milliseconds are becoming feasible and are used to study the state-of-the-art experiments in atomistic detail. Yet, analyzing the high-dimensional-long-temporal trajectory data is still a challenging task and sometimes leads to contradictory results depending on the analyses. To reveal the dynamic aspect of the trajectory, here we propose a simple approach which uses a time correlation function matrix and apply to the folding/unfolding trajectory of FiP35 WW domain [Shaw et al., Science 330, 341 (2010)]. Themore » approach successfully characterizes the slowest mode corresponding to the folding/unfolding transitions and determines the free energy barrier indicating that FiP35 is not an incipient downhill folder. The transition dynamics analysis further reveals that the folding/unfolding transition is highly heterogeneous, e.g., the transition path time varies by ∼100 fold. We identify two misfolded states and show that the dynamic heterogeneity in the folding/unfolding transitions originates from the trajectory being trapped in the misfolded and half-folded intermediate states rather than the diffusion driven by a thermal noise. The current results help reconcile the conflicting interpretations of the folding mechanism and highlight the complexity in the folding dynamics. This further motivates the need to understand the transition dynamics beyond a simple free energy picture using simulations and single-molecule experiments.« less

78 FR 60186 - Airworthiness Directives; AgustaWestland S.p.A. (Agusta) Helicopters

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-01

... avionics bay and the baggage compartment resulting from an Auto Transformer Rectifier Unit internal circuit... resulting in failure of the FIPS Auto Transformer Rectifier Unit to contain the internal circuit overload...

Chemical Compositions and Anomalies in Stellar Coronae

NASA Technical Reports Server (NTRS)

Drake, Jeremy; Oliversen, Ronald J. (Technical Monitor)

2005-01-01

In summary, as the papers cited here and in earlier reports demonstrate, this award has enabled us to obtain a fairly good picture of the abundance anomalies in stellar coronae. The "inverse FIP" effect in very active stars has now been fleshed out as a more complex anomaly depending on FIP, whereas before it appeared only in terms of a general metal paucity, the recent solar abundance assessment of Asplund et a1 will, if correct, challenge some of the older interpretations of coronal abundance anomalies since they imply quite different relative abundances of CNO compared with Fe, Mg and Si. Further investigations have been in into the possibility of modeling some of the recent coronal abundance anomaly results in terms of Alfven wave-driven separation of neutrals and ions in the upper chromosphere. This work still remains in the seed stage, and future funding from a different program will be requested to pursue it further.

The roles of MCP-1 and protein kinase C delta activation in human eosinophilic leukemia EoL-1 cells.

PubMed

Lee, Ji-Sook; Yang, Eun Ju; Kim, In Sik

2009-12-01

Idiopathic hypereosinophilc syndrome is a disorder associated with clonally eosinophilic proliferation. The importance of FIP1-like-1-platelet-derived growth factor receptor-alpha (FIP1L1-PDGFRA) in the pathogenesis and classification of HES has been recently reported. In this study, we investigated the contribution of monocyte chemoattractant protein-1 (MCP-1)/CCL2 to chemotactic activity and protein kinase C delta (PKC delta in the human eosinophilic leukemia cell line EoL-1. These cells express CCR2 protein among the CC chemokine receptors (CCR1-5). MCP-1 induces strong migration of EoL-1 cells and the chemotaxis signal in response to MCP-1 involves a G(i)/G(o) protein, phospholipase C (PLC), PKC delta, p38 MAPK and NF-kappaB. MCP-1 activates p38 MAPK via G(i)/G(o) protein, PLC and PKC delta cascade. MCP-1 also induces NF-kappaB translocation and the activation is inhibited by PKC delta activation. The increase in the basal expression and activity of PKC delta in EoL-1 cells, compared to normal eosinophils, inhibits apoptosis in EoL-1 cells. Anti-apoptotic mechanism of PKC delta is related to inhibition of caspase 3 and caspase 9, but not to FIP1L1-PDGFRA. PKC delta functions as an anti-apoptotic molecule, and is involved in EoL-1 cell movement stimulated by MCP-1. This study contributes to an understanding of MCP-1 in eosinophil biology and pathogenic mechanism of eosinophilic disorders.

Cobalt-chromium alloys in fixed prosthodontics in Sweden

PubMed Central

Kassapidou, Maria; Franke Stenport, Victoria; Hjalmarsson, Lars; Johansson, Carina B.

2017-01-01

Abstract Aim: The aim of this study was to compile the usage of Co-Cr alloys in fixed prosthodontics (FP) among dental laboratories in Sweden. Methods: From March to October 2015, questionnaires were sent to 542 registered dental laboratories in Sweden. The questionnaires were divided in two parts, one for fixed dental-supported prosthodontics (FDP) and one for fixed implant-supported prosthodontics (FIP). Reminders were sent three times. Results: In total of 542 dental laboratories, 55% answered the questionnaires. Most dental laboratories use Co-Cr in FP, 134 (74%) in FDP and 89(66%) in FIP. The laboratories used Co-Cr alloys of various compositions in the prostheses, 35 for FDP and 30 for FIP. The most commonly used Co-Cr alloys for tooth-supported FDPs were (a) Wirobond® 280, (b) Cara SLM and (c) Wirobond® C. For implant-supported frameworks the frequently used alloys were: (a) Cara SLM, (b) Cara Milled and (c) Wirobond® 280. Except for the difference in composition of these alloys, they were also manufactured with various techniques. In tooth-supported prostheses the dominating technique was the cast technique while newer techniques as laser-sintering and milling were more commonly reported for implant-supported constructions. A fourth technique; the ‘pre-state’ milling was reported in FDP. Conclusion: More than 30 different Co-Cr alloys were reported as being used in FP. Thus, there is a need for studies exploring the mechanical and physical behavior and the biological response to the most commonly used Co-Cr alloys. PMID:29242813

Increased Eps15 homology domain 1 and RAB11FIP3 expression regulate breast cancer progression via promoting epithelial growth factor receptor recycling.

PubMed

Tong, Dandan; Liang, Ya-Nan; Stepanova, A A; Liu, Yu; Li, Xiaobo; Wang, Letian; Zhang, Fengmin; Vasilyeva, N V

2017-02-01

Recent research indicates that the C-terminal Eps15 homology domain 1 is associated with epithelial growth factor receptor-mediated endocytosis recycling in non-small-cell lung cancer. The aim of this study was to determine the clinical significance of Eps15 homology domain 1 gene expression in relation to phosphorylation of epithelial growth factor receptor expression in patients with breast cancer. Primary breast cancer samples from 306 patients were analyzed for Eps15 homology domain 1, RAB11FIP3, and phosphorylation of epithelial growth factor receptor expression via immunohistochemistry. The clinical significance was assessed via a multivariate Cox regression analysis, Kaplan-Meier curves, and the log-rank test. Eps15 homology domain 1 and phosphorylation of epithelial growth factor receptor were upregulated in 60.46% (185/306) and 53.92% (165/306) of tumor tissues, respectively, as assessed by immunohistochemistry. The statistical correlation analysis indicated that Eps15 homology domain 1 overexpression was positively correlated with the increases in phosphorylation of epithelial growth factor receptor ( r = 0.242, p < 0.001) and RAB11FIP3 ( r = 0.165, p = 0.005) expression. The multivariate Cox proportional hazard model analysis demonstrated that the expression of Eps15 homology domain 1 alone is a significant prognostic marker of breast cancer for the overall survival in the total, chemotherapy, and human epidermal growth factor receptor 2 (-) groups. However, the use of combined expression of Eps15 homology domain 1 and phosphorylation of epithelial growth factor receptor markers is more effective for the disease-free survival in the overall population, chemotherapy, and human epidermal growth factor receptor 2 (-) groups. Moreover, the combined markers are also significant prognostic markers of breast cancer in the human epidermal growth factor receptor 2 (+), estrogen receptor (+), and estrogen receptor (-) groups. Eps15 homology domain 1 has a tumor suppressor function, and the combined marker of Eps15 homology domain 1/phosphorylation of epithelial growth factor receptor expression was identified as a better prognostic marker in breast cancer diagnosis. Furthermore, RAB11FIP3 combines with Eps15 homology domain 1 to promote the endocytosis recycling of phosphorylation of epithelial growth factor receptor.

A U.S. Geological Survey Data Standard (Specifications for representation of geographic point locations for information interchange)

USGS Publications Warehouse

,

1983-01-01

This standard establishes uniform formats for geographic point location data. Geographic point location refers to the use of a coordinate system to define the position of a point that may be on, above, or below the Earth's surface. It provides a means for representing these data in digital form for the purpose of interchanging information among data systems and improving clarity and accuracy of interpersonal communications. This document is an expansion and clarification of National Bureau of Standards FIPS PUB 70, issued October 24, 1980. There are minor editorial changes, plus the following additions and modifications: (I) The representation of latitude and longitude using radian measure was added. (2) Alternate 2 for Representation of Hemispheric Information was deleted. (3) Use of the maximum precision for all numerical values was emphasized. The Alternate Representation of Precision was deleted. (4) The length of the zone representation for the State Plane Coordinate System was standardized. (5) The term altitude was substituted for elevation throughout to conform with international usage. (6) Section 3, Specifications for Altitude Data, was expanded and upgraded significantly to the same level of detail as for the horizontal values. (7) A table delineating the coverage of Universal Transverse Mercator zones and the longitudes of the Central Meridians was added and the other tables renumbered. (8) The total length of the representation of point location data at maximum precision was standardized.

40 CFR 52.37 - What are the requirements of the Federal Implementation Plans (FIPs) to issue permits under the...

Code of Federal Regulations, 2011 CFR

2011-07-01

... requirements to sources that emit greenhouse gases? 52.37 Section 52.37 Protection of Environment ENVIRONMENTAL... permits under the Prevention of Significant Deterioration requirements to sources that emit greenhouse...

40 CFR 52.37 - What are the requirements of the Federal Implementation Plans (FIPs) to issue permits under the...

Code of Federal Regulations, 2013 CFR

2013-07-01

... requirements to sources that emit greenhouse gases? 52.37 Section 52.37 Protection of Environment ENVIRONMENTAL... permits under the Prevention of Significant Deterioration requirements to sources that emit greenhouse...

40 CFR 52.37 - What are the requirements of the Federal Implementation Plans (FIPs) to issue permits under the...

Code of Federal Regulations, 2014 CFR

2014-07-01

... requirements to sources that emit greenhouse gases? 52.37 Section 52.37 Protection of Environment ENVIRONMENTAL... permits under the Prevention of Significant Deterioration requirements to sources that emit greenhouse...

40 CFR 52.37 - What are the requirements of the Federal Implementation Plans (FIPs) to issue permits under the...

Code of Federal Regulations, 2012 CFR

2012-07-01

... requirements to sources that emit greenhouse gases? 52.37 Section 52.37 Protection of Environment ENVIRONMENTAL... permits under the Prevention of Significant Deterioration requirements to sources that emit greenhouse...

76 FR 20249 - Department of State Acquisition Regulation

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-12

... Department's procedures regarding personal identity verification of contractor personnel, as required by... (FIPS PUB) Number 201, Personal Identity Verification (PIV) of Federal Employees and Contractors. This... Identity Verification (PIV) of Federal Employees and Contractors. (See 71 FR 208, January 3, 2006). As...

48 CFR 4.1301 - Policy.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Policy. 4.1301 Section 4.1301 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL ADMINISTRATIVE MATTERS Personal Identity Verification 4.1301 Policy. (a) Agencies must follow FIPS PUB Number 201 and the...

48 CFR 4.1301 - Policy.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Policy. 4.1301 Section 4.1301 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL ADMINISTRATIVE MATTERS Personal Identity Verification 4.1301 Policy. (a) Agencies must follow FIPS PUB Number 201 and the...

An eight-year epidemiologic study based on baculovirus-expressed type-specific spike proteins for the differentiation of type I and II feline coronavirus infections

PubMed Central

2014-01-01

Background Feline infectious peritonitis (FIP) is a fatal disease caused by feline coronavirus (FCoV). FCoVs are divided into two serotypes with markedly different infection rates among cat populations around the world. A baculovirus-expressed type-specific domain of the spike proteins of FCoV was used to survey the infection of the two viruses over the past eight years in Taiwan. Results An immunofluorescence assay based on cells infected with the recombinant viruses that was capable of distinguishing between the two types of viral infection was established. A total of 833 cases from a teaching hospital was surveyed for prevalence of different FCoV infections. Infection of the type I FCoV was dominant, with a seropositive rate of 70.4%, whereas 3.5% of cats were infected with the type II FCoV. In most cases, results derived from serotyping and genotyping were highly agreeable. However, 16.7% (4/24) FIP cats and 9.8% (6/61) clinically healthy cats were found to possess antibodies against both viruses. Moreover, most of the cats (84.6%, 22/26) infected with a genotypic untypable virus bearing a type I FCoV antibody. Conclusion A relatively simple serotyping method to distinguish between two types of FCoV infection was developed. Based on this method, two types of FCoV infection in Taiwan was first carried out. Type I FCoV was found to be predominant compared with type II virus. Results derived from serotyping and genotyping support our current understanding of evolution of disease-related FCoV and transmission of FIP. PMID:25123112

The Plasma Environment at Mercury

NASA Technical Reports Server (NTRS)

Raines, James M.; Gershman, Daniel J.; Zurbuchen, Thomas H.; Gloeckler, George; Slavin, James A.; Anderson, Brian J.; Korth, Haje; Krimigis, Stamatios M.; Killen, Rosemary M.; Sarantos, Menalos;

Abundance Variations and Flows in Plage Regions Observed with CDS/SOHO

NASA Astrophysics Data System (ADS)

Rank, G.; Bagalá, L. G.; Czaykowska, A.; Haerendel, G.

1999-10-01

We present results from CDS/SOHO observations of the spotless active region NOAA-8208, obtained on 28th April 1998 near disk center. MDI images show a bipolar magnetic configuration. The regions of enhanced He I emission correspond to the areas with strong magnetic flux and also with bright plage areas seen in Ca II and H-alpha images. A high correlation is found between intensity maps of the transition region lines He I (logTmax = 4.3), O III (logTmax = 5.0), and O V (logTmax = 5.4). The line-of-sight velocities of He I reveal a strong downflow in the plage areas. Further, the line-of-sight velocities of He I, O III, and O V are well correlated, showing that the downflow pattern exists up to temperatures of about 0.25 MK. At higher temperatures (Mg VIII at logTmax = 5.8) this flow is not detected, suggesting that material streams into the plage region from sideways in the high transition region. Maps of the electron density in the transition region have been constructed from several line ratios yielding densities of about 9.0 cm-3 in the plage regions, about dex 0.5 cm-3 higher compared to the surrounding. To study the spatial variation of the first ionization potential (FIP) effect, the abundance ratio has been mapped for the ion ratio MgVI/NeVI. The ratio is highly variable on spatial scales down to a few arcsec from photospheric values to enhancements of a factor of 10. The strongest FIP enhancements are not correlated with transition region line emission, but are found outside of the plage regions. Some areas of strong FIP enhancement appear stretched and elongated, suggesting that the material is confined in loop-like structures.

SBAR Panel: Phase I Federal Implementation Plans (FIPs) To Reduce the Regional Transport of Ozone in the Eastern United States

EPA Pesticide Factsheets

SBAR panel on regional reductions of nitrogen oxides, with focus on the windborne transport of ozone smog and nitrogen oxides from NOx-producing sources in 22 eastern states and the District of Columbia

76 FR 48006 - Limited Federal Implementation Plan; Prevention of Significant Deterioration; California; North...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-08

... Implementation Plan; Prevention of Significant Deterioration; California; North Coast Unified Air Quality Management District AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule. SUMMARY: EPA is finalizing a limited Federal Implementation Plan (FIP) for the North Coast Unified Air Quality Management...

Biomethane

Science.gov Websites

; wastewater treatment; and industrial, institutional, and commercial organic waste (IIC). The purpose of this used in any advertising or publicity to endorse or promote any product or commercial entity using or FIPS ESRI OWCH4t Methane generation potential from industrial, institutional, and commercial organic

Global sale of tobacco products and electronic nicotine delivery systems in community pharmacies.

PubMed

Hudmon, Karen Suchanek; Elkhadragy, Nervana; Kusynová, Zuzana; Besançon, Luc; Brock, Tina Penick; Corelli, Robin L

2017-12-01

To estimate the proportion of countries/territories that allow sales of tobacco products and electronic nicotine delivery systems (ENDS) in community pharmacies. International Pharmaceutical Federation (FIP) member organisations were contacted by email and asked to respond to a two-item survey assessing whether their country/territory allowed sales of (a) tobacco products and (b) ENDS in community pharmacies. Of 95 countries/territories contacted, responses were received from 60 (63.2%). Seven countries (11.7%) reported that tobacco products were sold in community pharmacies, and 11 countries (18.3%) reported that ENDS were sold in community pharmacies. Among the FIP member organisations, there are few countries that allow the sale of tobacco products and ENDS in community pharmacies, with ENDS being more likely than tobacco products to be sold. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Nilotinib and Imatinib Are Comparably Effective in Reducing Growth of Human Eosinophil Leukemia Cells in a Newly Established Xenograft Model

PubMed Central

Salamon, Johannes; Thamer, Mohammed; Herrmann, Harald; Valent, Peter; Schumacher, Udo; Ullrich, Sebastian

2012-01-01

We developed a xenograft model of human Chronic Eosinophilic Leukemia (CEL) to study disease progression and remission-induction under therapy with tyrosine kinase inhibitors using imatinib and nilotinib as examples. The FIP1L1/PDGFRA+ human CEL cell lineEOL-1 was injected intravenously into scid mice, and MR imaging and FACS analysis of mouse blood samples were performed to monitor disease development and the effects of imatinib and nilotinib. Organ infiltration was analyzed in detail by immunohistochemistry after sacrifice. All animals developed CEL and within one week of therapy, complete remissions were seen with both imatinib and nilotinib, resulting in reduced total tumor volumes by MR-imaging and almost complete disappearance of EOL-1 cells in the peripheral blood and in tissues. The new model system is feasible for the evaluation of new tyrosine kinase inhibitors and our data suggest that nilotinib may be a valuable additional targeted drug active in patients with FIP1L1/PDGFRA+ CEL. PMID:22348015

Accumulation in coastal West Antarctic ice core records and the role of cyclone activity

NASA Astrophysics Data System (ADS)

Hosking, J. Scott; Fogt, Ryan; Thomas, Elizabeth R.; Moosavi, Vahid; Phillips, Tony; Coggins, Jack; Reusch, David

2017-09-01

Cyclones are an important component of Antarctic climate variability, yet quantifying their impact on the polar environment is challenging. We assess how cyclones which pass through the Bellingshausen Sea affect accumulation over Ellsworth Land, West Antarctica, where we have two ice core records. We use self-organizing maps (SOMs), an unsupervised machine learning technique, to group cyclones into nine SOM nodes differing by their trajectories (1980-2015). The annual frequency of cyclones associated with the first SOM node (SOM1, which generally originate from lower latitudes over the South Pacific Ocean) is significantly (p < 0.001) correlated with annual accumulation, with the highest seasonal correlations (p < 0.001) found during autumn. While significant (p < 0.01) increases in vertically integrated water vapor over the South Pacific Ocean coincide with this same group of cyclones, we find no indication that this has led to an increase in moisture advection into, nor accumulation over, Ellsworth Land over this short time period.

78 FR 16825 - Approval of Air Quality Implementation Plans; Navajo Nation; Regional Haze Requirements for...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-19

... Quality Implementation Plans; Navajo Nation; Regional Haze Requirements for Navajo Generating Station... source-specific federal implementation plan (FIP) requiring the Navajo Generating Station (NGS), located... . SUPPLEMENTARY INFORMATION: Throughout this document, ``we'', ``us'', and ``our'' refer to EPA. Table of Contents...

Documents for SBAR Panel: Phase I Federal Implementation Plans (FIPs) To Reduce the Regional Transport of Ozone in the Eastern United States

EPA Pesticide Factsheets

SBAR panel on regional reductions of nitrogen oxides, with focus on the windborne transport of ozone smog and nitrogen oxides from NOx-producing sources in 22 eastern states and the District of Columbia

40 CFR 52.2305 - What are the requirements of the Federal Implementation Plan (FIP) to issue permits under the...

Code of Federal Regulations, 2011 CFR

2011-07-01

... requirements to sources that emit greenhouse gases? 52.2305 Section 52.2305 Protection of Environment... greenhouse gases? (a) The requirements of sections 160 through 165 of the Clean Air Act are not met to the...

40 CFR 52.2305 - What are the requirements of the Federal Implementation Plan (FIP) to issue permits under the...

Code of Federal Regulations, 2012 CFR

2012-07-01

... requirements to sources that emit greenhouse gases? 52.2305 Section 52.2305 Protection of Environment... greenhouse gases? (a) The requirements of sections 160 through 165 of the Clean Air Act are not met to the...

40 CFR 52.2305 - What are the requirements of the Federal Implementation Plan (FIP) to issue permits under the...

Code of Federal Regulations, 2013 CFR

2013-07-01

... requirements to sources that emit greenhouse gases? 52.2305 Section 52.2305 Protection of Environment... greenhouse gases? (a) The requirements of sections 160 through 165 of the Clean Air Act are not met to the...

40 CFR 52.2305 - What are the requirements of the Federal Implementation Plan (FIP) to issue permits under the...

Code of Federal Regulations, 2014 CFR

2014-07-01

... requirements to sources that emit greenhouse gases? 52.2305 Section 52.2305 Protection of Environment... greenhouse gases? (a) The requirements of sections 160 through 165 of the Clean Air Act are not met to the...

The current use of patient-centered/reported outcomes in implant dentistry: a systematic review.

PubMed

De Bruyn, Hugo; Raes, Stefanie; Matthys, Carine; Cosyn, Jan

2015-09-01

To provide an update on the use of Patient-Reported Outcome Measures (PROMs) in the field of implant dentistry (1); to compare PROMs for prostheses supported by one or more implants to alternative treatment options or a healthy dentition (2). The dental literature was searched on PubMed until December 31, 2014, using a general search algorithm. An overall quantitative analysis was performed, and a qualitative appraisal was made on the output of the last 6 years. Per type of edentulism and prosthetic treatment, the general search algorithm was refined in order to select controlled studies comparing PROMs for prostheses supported by one or more implants to alternative treatment options or a healthy dentition. With nearly half of the output (300 of 635) published in the last 6 years, there is a growing interest in PROMs by the scientific community. When scrutinizing the 300 most recent publications, only 84 controlled studies could be identified among which 38 RCTs and 31 cohort studies. An "ad hoc" approach is commonly employed using non-standardized questions and different scoring methods, which may compromise validity and reliability. Overall, 39 eligible papers related to fully edentulous patients treated with an implant overdenture (IOD) and 9 to fully edentulous patients treated with a fixed implant prosthesis (FIP). There is plenty of evidence from well-controlled studies showing that fully edentulous patients in the mandible experience higher satisfaction with an IOD when compared to a conventional denture (CD). This may not hold true for fully edentulous patients in the maxilla. In general, fully edentulous patients seem to opt for a fixed or removable rehabilitation on implants for specific reasons. Data pertaining to partially edentulous patients were limited (FIP: n = 6; single implants: n = 16). In these patients, the timing of implant placement does not seem to affect patient satisfaction. Patients seem to prefer straightforward implant surgery over complex surgery that includes bone grafting. There is an urgent need for standardized reporting of PROMs in the field of implant dentistry. Fully edentulous patients in the mandible experience higher satisfaction with an IOD when compared to a CD. All other types of prostheses have been underexposed to research. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Volume, size, professionals' specialization and nutrition management of NICUs and their association with treatment quality in VLBW infants.

PubMed

Miedaner, Felix; Langhammer, Kristina; Enke, Christian; Göpel, Wolfgang; Kribs, Angela; Nitzsche, Anika; Riedel, Rainer; Woopen, Christiane; Kuntz, Ludwig; Roth, Bernhard

2018-04-01

To assess the association of volume, size, the availability of highly-specialized professionals and nutrition management of NICUs with treatment quality among VLBW infants. A prospective multicenter study of 923 VLBW infants in 66 German NICUs, born between May and October 2013. Using multilevel modeling, we examined the association between the aforementioned organizational characteristics and treatment quality, measured via major morbidities (severe IVH, PVL, BPD, NEC, FIP, ROP, and discharge without severe complications) and medical process measures of VLBW infants. After risk-adjustment and accounting for other NICU characteristics, infants in low-volume NICUs were at higher risk of IVH, ROP and PVL. However, the initial effect of volume on process measures (growth velocity, administration of antenatal steroids) disappeared. Volume can only partially explain differences in the treatment quality of VLBWs. The underlying organizational mechanisms should be considered to improve the quality of care.

Status of Clean Air Act (CAA) 110(a)(2)(D)(i)(I) SIPs Final Rule TSD

EPA Pesticide Factsheets

This document describes, for each state subject to a Federal implementation plan (FIP) with respect to ozone and/or PM2.5 NAAQS under the Transport Rule, the status of each Clean Air Act state implementation plan (SIP) for the relevant NAAQS.

78 FR 41731 - Source Specific Federal Implementation Plan for Implementing Best Available Retrofit Technology...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-11

... Federal Implementation Plan for Implementing Best Available Retrofit Technology for Four Corners Power... Implementation Plan (FIP) to implement the Best Available Retrofit Technology (BART) requirement of the Regional... given the uncertainties in the electrical market in Arizona, EPA is proposing to extend the date by...

NOAA Weather Radio

Science.gov Websites

Station Search Coverage Maps Outages View Outages Report Outages Information General Information Receiver Information Reception Problems NWR Alarms Automated Voices FIPS Codes NWR - Special Needs SAME USING SAME SAME Search For Go NWS All NOAA Frequently Asked Questions This site offers a wealth of information on NOAA

NOAA Weather Radio - All Hazards

Science.gov Websites

Station Search Coverage Maps Outages View Outages Report Outages Information General Information Receiver Information Reception Problems NWR Alarms Automated Voices FIPS Codes NWR - Special Needs SAME USING SAME SAME Weather Service (NWS) warnings, watches, forecasts and other non-weather related hazard information 24

Student and Parent Perspectives on Fipping the Mathematics Classroom

ERIC Educational Resources Information Center

Muir, Tracey

2015-01-01

Traditionally, the domain of higher education, the 'flipped classroom' is gaining in popularity in secondary school settings. In the flipped classroom, digital technologies are used to shift direct instruction from the classroom to the home, providing students with increased autonomy over their learning. While advocates of the approach believe it…

Notice of Intent: Effect of Stay of Transport Rule

EPA Pesticide Factsheets

A December 30, 2011 order of the U.S. Court of Appeals for the District of Columbia Circuit stayed the Transport Rule, also known as the Cross-State Air Pollution Rule. This document sets out EPA’s interpretation of the effect of the Court’s stay on FIPs.

Calibration of stereo rigs based on the backward projection process

NASA Astrophysics Data System (ADS)

Gu, Feifei; Zhao, Hong; Ma, Yueyang; Bu, Penghui; Zhao, Zixin

2016-08-01

High-accuracy 3D measurement based on binocular vision system is heavily dependent on the accurate calibration of two rigidly-fixed cameras. In most traditional calibration methods, stereo parameters are iteratively optimized through the forward imaging process (FIP). However, the results can only guarantee the minimal 2D pixel errors, but not the minimal 3D reconstruction errors. To address this problem, a simple method to calibrate a stereo rig based on the backward projection process (BPP) is proposed. The position of a spatial point can be determined separately from each camera by planar constraints provided by the planar pattern target. Then combined with pre-defined spatial points, intrinsic and extrinsic parameters of the stereo-rig can be optimized by minimizing the total 3D errors of both left and right cameras. An extensive performance study for the method in the presence of image noise and lens distortions is implemented. Experiments conducted on synthetic and real data demonstrate the accuracy and robustness of the proposed method.

WATERSHED INFARCTION IN HYPEREOSINOPHILIC SYNDROME: A DIAGNOSTIC DILEMMA IN FIP1L1-PDGFR ALPHA-ASSOCIATED MYELOID NEOPLASM.

PubMed

Marton, Imelda; Pósfai, Éva; Annus, János Kristóf; Borbényi, Zita; Nemes, Attila; Vecsei, László; Vörös, Erika

2015-05-30

The FIP1L1-PDGFR alpha-positive, hypereosinophilic syndrome (HES) is a new category of hematological entities. Various clinical symptoms may occur, with no specific characteristics in either the clinical picture or the neuroimaging findings, and this may give rise to a diagnostic dilemma. A report on a long follow-up period (10 years) in a case of HES that presented with neuropsychiatric symptoms appears to be unique. Besides the complexity of the diagnostic process, the successful treatment is discussed. The HES was diagnosed in a male patient at the age of 33 years, with involvement of the central nervous system and the myocardium. After the onset of the clinical signs, the MRI indicated bilateral cerebral and cerebellar cortico-subcortical lesions involving the watershed areas, mainly in the parieto-occipital regions. High-dose intravenous steroid (methylprednisolone 500 mg/day) alleviated the neurological symptoms within a few weeks, and the administration of imatinib (200 mg/day) resulted in an impressive regression of the hypereosinophilia and splenomegaly within 6 weeks. During the follow-up, the patient has continued to receive imatinib. The molecular remission has persisted, no new complaints have developed and the condition of the patient has remained stable. The timely recognition of the HES and identification of the disease subtype which led to the administration of imatinib may be the key to successful treatment. The long stable follow-up period gives rise to a new dilemma in the treatment of the HES in these special cases: for how long should a patient receive a tyrosine kinase inhibitor, and may the treatment be suspended?

Systematic Profiling of Poly(A)+ Transcripts Modulated by Core 3’ End Processing and Splicing Factors Reveals Regulatory Rules of Alternative Cleavage and Polyadenylation

PubMed Central

Li, Wencheng; You, Bei; Hoque, Mainul; Zheng, Dinghai; Luo, Wenting; Ji, Zhe; Park, Ji Yeon; Gunderson, Samuel I.; Kalsotra, Auinash; Manley, James L.; Tian, Bin

2015-01-01

Alternative cleavage and polyadenylation (APA) results in mRNA isoforms containing different 3’ untranslated regions (3’UTRs) and/or coding sequences. How core cleavage/polyadenylation (C/P) factors regulate APA is not well understood. Using siRNA knockdown coupled with deep sequencing, we found that several C/P factors can play significant roles in 3’UTR-APA. Whereas Pcf11 and Fip1 enhance usage of proximal poly(A) sites (pAs), CFI-25/68, PABPN1 and PABPC1 promote usage of distal pAs. Strong cis element biases were found for pAs regulated by CFI-25/68 or Fip1, and the distance between pAs plays an important role in APA regulation. In addition, intronic pAs are substantially regulated by splicing factors, with U1 mostly inhibiting C/P events in introns near the 5’ end of gene and U2 suppressing those in introns with features for efficient splicing. Furthermore, PABPN1 inhibits expression of transcripts with pAs near the transcription start site (TSS), a property possibly related to its role in RNA degradation. Finally, we found that groups of APA events regulated by C/P factors are also modulated in cell differentiation and development with distinct trends. Together, our results support an APA code where an APA event in a given cellular context is regulated by a number of parameters, including relative location to the TSS, splicing context, distance between competing pAs, surrounding cis elements and concentrations of core C/P factors. PMID:25906188

Experimental Evidence that Hemlock Mortality Enhances Carbon Stabilization in Southern Appalachian Forest Soils

NASA Astrophysics Data System (ADS)

Fraterrigo, J.; Ream, K.; Knoepp, J.

2017-12-01

Forest insects and pathogens (FIPs) can cause uncertain changes in forest carbon balance, potentially influencing global atmospheric carbon dioxide (CO2) concentrations. We quantified the effects of hemlock (Tsuga canadensis L. Carr.) mortality on soil carbon fluxes and pools for a decade following either girdling or natural infestation by hemlock woolly adelgid (HWA; Adelges tsugae) to improve mechanistic understanding of soil carbon cycling response to FIPs. Although soil respiration (Rsoil) was similar among reference plots and plots with hemlock mortality, both girdled and HWA-infested plots had greater activities of β-glucosidase, a cellulose-hydrolyzing extracellular enzyme, and decreased O-horizon mass and fine root biomass from 2005 to 2013. During this period, total mineral soil carbon accumulated at a higher rate in disturbed plots than in reference plots in both the surface (0-10 cm) and subsurface (10-30 cm); increases were predominantly in the mineral-associated fraction of the soil organic matter. In contrast, particulate organic matter carbon accrued slowly in surface soils and declined in the subsurface of girdled plots. δ13C values of this fraction demonstrate that particulate organic matter carbon in the surface soil has become more microbially processed over time, suggesting enhanced decomposition of organic matter in this pool. Together, these findings indicate that hemlock mortality and subsequent forest regrowth has led to enhanced soil carbon stabilization in southern Appalachian forests through the translocation of carbon from detritus and particulate soil organic matter pools to the mineral-associated organic matter pool. These findings have implications for ecosystem management and modeling, demonstrating that forests may tolerate moderate disturbance without diminishing soil carbon storage when there is a compensatory growth response by non-host trees.

Report of official foreign travel to France, June 7--20, 2000

DOE Office of Scientific and Technical Information (OSTI.GOV)

J.D. Mason

2000-07-11

The Department of Energy (DOE) has moved rapidly toward electronic production, management, and dissemination of scientific and technical information. The World-Wide Web (WWW) has become a primary means of information dissemination. Electronic commerce (EC) is becoming the preferred means of procurement. DOE, like other government agencies, depends on and encourages the use of international standards in data communications. Like most government agencies, DOE has expressed a preference for openly developed standards over proprietary designs promoted as ``standards'' by vendors. In particular, there is a preference for standards developed by organizations such as the International Organization for Standardization (ISO) and themore » American National Standards Institute (ANSI) that use open, public processes to develop their standards. Among the most widely adopted international standards is the Standard Generalized Markup Language (SGML, ISO 8879:1986, FIPS 152), to which DOE long ago made a commitment. Besides the official commitment, which has resulted in several specialized projects, DOE makes heavy use of coding derived from SGML: Most documents on the WWW are coded in HTML (Hypertext Markup Language), which is an application of SGML. The World-Wide Web Consortium (W3C), with the backing of major software houses like Adobe, IBM, Microsoft, Netscape, Oracle, and Sun, is promoting XML (eXtensible Markup Language), a class of SGML applications, for the future of the WWW and the basis for EC. In support of DOE's use of these standards, the authors has served since 1985 as Chairman of the international committee responsible for SGML and related standards, ISO/IEC JTC1/SC34 (SC34) and its predecessor organizations. During his June 2000 trip, he chaired the spring 2000 meeting of SC34 in Paris, France. He also attended a major conference on the use of SGML and XML and led a meeting of the International SGML/XML Users' Group (ISUG). In addition to the widespread use of the WWW among DOE's plants and facilities in Oak Ridge and among DOE sites across the nation, there are several SGML-based projects at the Oak Ridge Y-12 Plant. The local project team developed an SGML-based publications system that has been used for several major reports at the Y-12 Plant and Oak Ridge National Laboratory (ORNL). SGML is a component of the Weapons Records Archiving and Preservation (WRAP) project at the Y-12 Plant and is the format for catalog metadata chosen for weapons records by the Nuclear Weapons Information Group (NWIG). The Ferret system for automated classification analysis will use XML to structure its knowledge base. Supporting standards development allows DOE and the Y-12 plant the opportunity both to provide input into the process and to benefit from contact with some of the leading experts in the subject matter. Oak Ridge has been for some years the location to which other DOE sites turn for expertise in SGML and related topics.« less

40 CFR 52.1240 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Minnesota § 52.1240 Interstate pollutant...) The owner and operator of each source located within the State of Minnesota and for which requirements... Administrator of a revision to the Minnesota State Implementation Plan (SIP) as meeting the requirements of CAIR...

40 CFR 52.1240 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2011 CFR

2011-07-01

...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Minnesota § 52.1240 Interstate pollutant...) The owner and operator of each source located within the State of Minnesota and for which requirements... Administrator of a revision to the Minnesota State Implementation Plan (SIP) as meeting the requirements of CAIR...

40 CFR 52.1240 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Minnesota § 52.1240 Interstate pollutant...) The owner and operator of each source located within the State of Minnesota and for which requirements... Administrator of a revision to the Minnesota State Implementation Plan (SIP) as meeting the requirements of CAIR...

40 CFR 52.1240 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2010 CFR

2010-07-01

...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Minnesota § 52.1240 Interstate pollutant...) The owner and operator of each source located within the State of Minnesota and for which requirements... Administrator of a revision to the Minnesota State Implementation Plan (SIP) as meeting the requirements of CAIR...

40 CFR 52.1240 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2014 CFR

2014-07-01

...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Minnesota § 52.1240 Interstate pollutant...) The owner and operator of each source located within the State of Minnesota and for which requirements... Administrator of a revision to the Minnesota State Implementation Plan (SIP) as meeting the requirements of CAIR...

Hearing Schedule and List of Speakers for the Public Hearing on Revisions to FIPs to Reduce Interstate Transport of Fine Particulate Matter and Ozone – October 28, 2011, Washington, D.C.

EPA Pesticide Factsheets

List of Speakers and Hearing Schedule for the October 28 Public Hearing on the proposed Revisions to the Federal Implementation Plans to Reduce Interstate Transport of Fine Particulate Matter and Ozone.

NOAA Weather Radio - Voice of NWS

Science.gov Websites

Station Search Coverage Maps Outages View Outages Report Outages Information General Information Receiver Information Reception Problems NWR Alarms Automated Voices FIPS Codes NWR - Special Needs SAME USING SAME SAME information 24 hours a day. Known as the "voice of the National Weather Service," NWR is provided as

76 FR 48207 - Federal Implementation Plans: Interstate Transport of Fine Particulate Matter and Ozone and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-08

... Problems and NAAQS Addressed 1. Air Quality Problems and NAAQS Addressed 2. FIP Authority for Each State... resolve nonattainment or maintenance problems at downwind state receptors. Downwind states also have... are fossil fuel-fired boilers and turbines producing electricity for sale, as detailed in section VII...

40 CFR 52.1628 - Interstate pollutant transport and regional haze provisions; what are the FIP requirements for...

Code of Federal Regulations, 2012 CFR

2012-07-01

... midnight. Air pollution control equipment includes baghouses, particulate or gaseous scrubbers, and any... owner or operator shall submit a plan to the Regional Administrator that identifies the air pollution... shall, to the extent practicable, maintain and operate the unit including associated air pollution...

40 CFR 52.1628 - Interstate pollutant transport and regional haze provisions; what are the FIP requirements for...

Code of Federal Regulations, 2014 CFR

2014-07-01

... midnight. Air pollution control equipment includes baghouses, particulate or gaseous scrubbers, and any... owner or operator shall submit a plan to the Regional Administrator that identifies the air pollution... shall, to the extent practicable, maintain and operate the unit including associated air pollution...

40 CFR 52.1628 - Interstate pollutant transport and regional haze provisions; what are the FIP requirements for...

Code of Federal Regulations, 2013 CFR

2013-07-01

... midnight. Air pollution control equipment includes baghouses, particulate or gaseous scrubbers, and any... owner or operator shall submit a plan to the Regional Administrator that identifies the air pollution... shall, to the extent practicable, maintain and operate the unit including associated air pollution...

40 CFR 52.2587 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2014 CFR

2014-07-01

...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Wisconsin § 52.2587 Interstate pollutant...) The owner and operator of each source located within the State of Wisconsin and for which requirements... Administrator of a revision to the Wisconsin State Implementation Plan (SIP) as meeting the requirements of CAIR...

40 CFR 52.2587 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Wisconsin § 52.2587 Interstate pollutant...) The owner and operator of each source located within the State of Wisconsin and for which requirements... Administrator of a revision to the Wisconsin State Implementation Plan (SIP) as meeting the requirements of CAIR...

40 CFR 52.2587 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2011 CFR

2011-07-01

...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Wisconsin § 52.2587 Interstate pollutant...) The owner and operator of each source located within the State of Wisconsin and for which requirements... Administrator of a revision to the Wisconsin State Implementation Plan (SIP) as meeting the requirements of CAIR...

40 CFR 52.2587 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Wisconsin § 52.2587 Interstate pollutant...) The owner and operator of each source located within the State of Wisconsin and for which requirements... Administrator of a revision to the Wisconsin State Implementation Plan (SIP) as meeting the requirements of CAIR...

40 CFR 52.2587 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2010 CFR

2010-07-01

...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Wisconsin § 52.2587 Interstate pollutant...) The owner and operator of each source located within the State of Wisconsin and for which requirements... Administrator of a revision to the Wisconsin State Implementation Plan (SIP) as meeting the requirements of CAIR...

77 FR 65125 - Approval and Promulgation of Implementation Plans; Georgia 110(a)(1) and (2) Infrastructure...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-25

... controls are enforced through the associated SIP rules or Federal Implementation Plans (FIPs). Any purchase... Promulgation of Implementation Plans; Georgia 110(a)(1) and (2) Infrastructure Requirements for the 1997 and... Agency (EPA). ACTION: Final rule. SUMMARY: EPA is taking final action to approve the State Implementation...

Securing Location Services Infrastructures: Practical Criteria for Application Developers and Solutions Architects

ERIC Educational Resources Information Center

Karamanian, Andre

2013-01-01

This qualitative, exploratory, normative study examined the security and privacy of location based services in mobile applications. This study explored risk, and controls to implement privacy and security. This study was addressed using components of the FIPS Risk Management Framework. This study found that risk to location information was…

Skin fragility syndrome in a cat with feline infectious peritonitis and hepatic lipidosis.

PubMed

Trotman, Tara K; Mauldin, Elizabeth; Hoffmann, Vickie; Del Piero, Fabio; Hess, Rebecka S

2007-10-01

A 6-year-old spayed female domestic shorthair cat with a 3-week history of inappetence, weight loss, and hiding was examined. A palpable abdominal fluid wave, dehydration, and a small tear on the left flank were noted during initial examination. When the cat was gently restrained for blood sampling, the skin on the dorsal neck tore, leaving a 15 cm x 7 cm flap of skin. Clinicopathological abnormalities included nonregenerative anaemia, hypoalbuminaemia, increased globulin concentration, and mildly elevated aspartate aminotransferase and alkaline phosphatase activities. Abdominal fluid was viscous and had a total protein of 5.3 g dL(-1) with 316 cells microL(-1), consistent with a modified transudate. Cytology of the abdominal fluid revealed 86% nondegenerate neutrophils, 13% macrophages, and 1% small lymphocytes. Histopathological evaluation and indirect immunohistochemistry confirmed a diagnosis of feline infectious peritonitis, hepatic lipidosis and feline skin fragility syndrome. Feline skin fragility syndrome has not previously been reported in association with feline infectious peritonitis (FIP). Its inclusion as a clinical sign associated with FIP may facilitate a diagnosis.

The CFHT MegaCam control system: new solutions based on PLCs, WorldFIP fieldbus and Java softwares

NASA Astrophysics Data System (ADS)

Rousse, Jean Y.; Boulade, Olivier; Charlot, Xavier; Abbon, P.; Aune, Stephan; Borgeaud, Pierre; Carton, Pierre-Henri; Carty, M.; Da Costa, J.; Deschamps, H.; Desforge, D.; Eppele, Dominique; Gallais, Pascal; Gosset, L.; Granelli, Remy; Gros, Michel; de Kat, Jean; Loiseau, Denis; Ritou, J. L.; Starzynski, Pierre; Vignal, Nicolas; Vigroux, Laurent G.

2003-03-01

MegaCam is a wide-field imaging camera built for the prime focus of the 3.6m Canada-France-Hawaii Telescope. This large detector has required new approaches from the hardware up to the instrument control system software. Safe control of the three sub-systems of the instrument (cryogenics, filters and shutter), measurement of the exposure time with an accuracy of 0.1%, identification of the filters and management of the internal calibration source are the major challenges that are taken up by the control system. Another challenge is to insure all these functionalities with the minimum space available on the telescope structure for the electrical hardware and a minimum number of cables to keep the highest reliability. All these requirements have been met with a control system which different elements are linked by a WorldFip fieldbus on optical fiber. The diagnosis and remote user support will be insured with an Engineering Control System station based on software developed on Internet JAVA technologies (applets, servlets) and connected on the fieldbus.

Neurokinin-1 enables measles virus trans-synaptic spread in neurons

DOE Office of Scientific and Technical Information (OSTI.GOV)

Makhortova, Nina R.; Askovich, Peter; Patterson, Catherine E.

2007-05-25

Measles virus (MV), a morbillivirus that remains a significant human pathogen, can infect the central nervous system, resulting in rare but often fatal diseases, such as subacute sclerosing panencephalitis. Previous work demonstrated that MV was transmitted trans-synaptically and that, while a cellular receptor for the hemagglutinin (H) protein was required for MV entry, it was dispensable for subsequent cell-to-cell spread. Here, we explored what role the other envelope protein, fusion (F), played in trans-synaptic transport. We made the following observations: (1) MV-F expression in infected neurons was similar to that seen in infected fibroblasts; (2) fusion inhibitory peptide (FIP), anmore » inhibitor of MV fusion, prevented both infection and spread in primary neurons; (3) Substance P, a neurotransmitter with the same active site as FIP, also blocked neuronal MV spread; and (4) both genetic deletion and pharmacological inhibition of the Substance P receptor, neurokinin-1 (NK-1), reduced infection of susceptible mice. Together, these data implicate a role for NK-1 in MV CNS infection and spread, perhaps serving as an MV-F receptor or co-receptor on neurons.« less

Feline coronavirus: Insights into viral pathogenesis based on the spike protein structure and function.

PubMed

Jaimes, Javier A; Whittaker, Gary R

2018-04-01

Feline coronavirus (FCoV) is an etiological agent that causes a benign enteric illness and the fatal systemic disease feline infectious peritonitis (FIP). The FCoV spike (S) protein is considered the viral regulator for binding and entry to the cell. This protein is also involved in FCoV tropism and virulence, as well as in the switch from enteric disease to FIP. This regulation is carried out by spike's major functions: receptor binding and virus-cell membrane fusion. In this review, we address important aspects in FCoV genetics, replication and pathogenesis, focusing on the role of S. To better understand this, FCoV S protein models were constructed, based on the human coronavirus NL63 (HCoV-NL63) S structure. We describe the specific structural characteristics of the FCoV S, in comparison with other coronavirus spikes. We also revise the biochemical events needed for FCoV S activation and its relation to the structural features of the protein. Copyright © 2018 Elsevier Inc. All rights reserved.

How Many Words Does a Picture Really Tell? Cross-sectional Descriptive Study of Pictogram Evaluation by Youth.

PubMed

Korenevsky, Artyom; Vaillancourt, Régis; Pouliot, Annie; Revol, Marine; Steed, Evan; Besançon, Luc; Wahrendorf, Marit-Saskia; Patel, Jaimisha R

2013-07-01

Communicating health-related instructions with pictograms is useful, but such graphics can be interpreted in different ways. It is crucial to understand which pictogram components are best for accurate communication. To catalogue pictograms used to label drugs in clinical practice; to identify the common graphic elements for defined categories of pictograms, by performing a semiotic analysis (studying how signs are perceived and how they should be designed); to identify the key graphic elements common to pictograms preferred by users; and to develop suggestions for future pictogram design on the basis of users' input. Literature and Internet searches were performed to identify pictograms and pictogram categories. A call for pictograms was also circulated through the International Pharmaceutical Federation (FIP). Youth at a Canadian pediatric hospital were asked to rate pictograms (including storyboards and prescription labels generated by FIP pictogram software) in terms of how best they represented their intended meanings. Pictograms for which at least 80% of participants "somewhat agreed", "agreed", or "strongly agreed" that the graphic conveyed the intended meaning were designated as "preferred" and were selected for analysis. Elements appearing in at least 50% of these preferred pictograms were highlighted as key graphic elements for design of future pictograms. In total, 21 categories were identified for pictograms used in clinical practice, and a total of 204 pictograms were analyzed. Eighty-six participants took part in the survey. For each pictogram category, certain elements were identified as "preferred" and as "key graphic elements", whereas other elements met neither designation. For all 21 pictogram categories, at least 80% of survey respondents agreed that the FIP storyboard conveyed the intended meaning. Certain key, preferred graphic elements are required for pharmaceutical pictograms to convey their intended meaning. The overlap between preferred and key pictogram elements indicates that both must be considered in development of future pictograms. Redesign of existing pictograms with consideration of the best semiotic elements is in progress.

Atg17/FIP200 localizes to perilysosomal Ref(2)P aggregates and promotes autophagy by activation of Atg1 in Drosophila.

PubMed

Nagy, Péter; Kárpáti, Manuéla; Varga, Agnes; Pircs, Karolina; Venkei, Zsolt; Takáts, Szabolcs; Varga, Kata; Erdi, Balázs; Hegedűs, Krisztina; Juhász, Gábor

2014-03-01

Phagophore-derived autophagosomes deliver cytoplasmic material to lysosomes for degradation and reuse. Autophagy mediated by the incompletely characterized actions of Atg proteins is involved in numerous physiological and pathological settings including stress resistance, immunity, aging, cancer, and neurodegenerative diseases. Here we characterized Atg17/FIP200, the Drosophila ortholog of mammalian RB1CC1/FIP200, a proposed functional equivalent of yeast Atg17. Atg17 disruption inhibits basal, starvation-induced and developmental autophagy, and interferes with the programmed elimination of larval salivary glands and midgut during metamorphosis. Upon starvation, Atg17-positive structures appear at aggregates of the selective cargo Ref(2)P/p62 near lysosomes. This location may be similar to the perivacuolar PAS (phagophore assembly site) described in yeast. Drosophila Atg17 is a member of the Atg1 kinase complex as in mammals, and we showed that it binds to the other subunits including Atg1, Atg13, and Atg101 (C12orf44 in humans, 9430023L20Rik in mice and RGD1359310 in rats). Atg17 is required for the kinase activity of endogenous Atg1 in vivo, as loss of Atg17 prevents the Atg1-dependent shift of endogenous Atg13 to hyperphosphorylated forms, and also blocks punctate Atg1 localization during starvation. Finally, we found that Atg1 overexpression induces autophagy and reduces cell size in Atg17-null mutant fat body cells, and that overexpression of Atg17 promotes endogenous Atg13 phosphorylation and enhances autophagy in an Atg1-dependent manner in the fat body. We propose a model according to which the relative activity of Atg1, estimated by the ratio of hyper- to hypophosphorylated Atg13, contributes to setting low (basal) vs. high (starvation-induced) autophagy levels in Drosophila.

Origins Space Telescope: The Far Infrared Imager and Polarimeter FIP

NASA Astrophysics Data System (ADS)

Staguhn, Johannes G.; Chuss, David; Howard, Joseph; Meixner, Margaret; Vieira, Joaquin; Amatucci, Edward; Bradley, Damon; Carter, Ruth; Cooray, Asantha; Flores, Anel; Leisawitz, David; Moseley, Samuel Harvey; Wollack, Edward; Origins Space Telescope Study Team

2018-01-01

The Origins Space Telescope (OST)* is the mission concept for the Far-Infrared Surveyor, one of the four science and technology definition studies of NASA Headquarters for the 2020 Astronomy and Astrophysics Decadal survey. The current "concept 1", which envisions a cold (4K) 9m space telescope, includes 5 instruments, providing a wavelength coverage ranging from 6um and 667um. The achievable sensitivity of the observatory will provide three to four orders of magnitude of improvement in sensitivity over current observational capabilities, allowing to address a wide range of new and so far inaccessible scientific questions, ranging from bio-signatures on exo-planets to mapping primordial H_2 from the "dark ages" before the universe went through the phase of re-ionization.Here we present the Far Infrared Imager and Polarimeter (FIP) for OST. The cameral will cover four bands, 40um, 80um, 120um, and 240um. It will allow for differential polarimetry in those bands with the ability to observe two colors in polarimtery mode simultaneously, while all four bands can be observed simultaneously in total power mode. While the confusion limit will be reached in only 32ms at 240um, at 40um the source density on the sky is so low, that at the angular resolution of 1" of OST at this wavelength there will be no source confusion, even for the longest integration times. Science topics that can be addressed by FIP include but are not limited to galactic and extragalactic magnetic field studies, Deep Galaxy Surveys, and Outer Solar System objects..*Origins will enable flagship-quality general observing programs led by the astronomical community in the 2030s. We welcome you to contact the Science and Technology Definition Team (STDT) with your science needs and ideas by emailing us at ost_info@lists.ipac.caltech.edu

The Heavy Nuclei eXplorer (HNX) Mission

NASA Technical Reports Server (NTRS)

Binns, W. R.; Adams, J. H.; Barbier, L. M.; Craig, N.; Cummings, A. C.; Cummings, J. R.; Doke, T.; Hasebe, N.; Hayashi, T.; Whitaker, Ann F. (Technical Monitor)

2001-01-01

The primary scientific objectives of HNX, which was recently selected by NASA for a Small Explorer (SMEX) Mission Concept Study, are to measure the age of the galactic cosmic rays (GCR) since nucleosynthesis, determine the injection mechanism for the GCR accelerator (Volatility or FIP), and study the mix of nucleosynthetic processes that contribute to the source of GCRs. The experimental goal of HNX is to measure the elemental abundances of all individual stable nuclei from neon through the actinides and possibly beyond. HNX is composed of two instruments: ECCO, which measures elemental abundances of nuclei with Z greater than or equal to 72, and ENTICE. which measures elemental abundances of nuclei with Z between 10 and 82. We describe the mission and the science that can be addressed by HNX.

75 FR 82429 - Determinations Concerning Need for Error Correction, Partial Approval and Partial Disapproval...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-30

...EPA is correcting its previous full approval of Texas's Clean Air Act (CAA) Prevention of Significant Deterioration (PSD) program to be a partial approval and partial disapproval. The state did not address, or provide adequate legal authority for, the program's application to all pollutants that would become newly subject to regulation in the future, including non-National Ambient Air Quality Standard (NAAQS) pollutants, among them greenhouse gases (GHGs). Further, EPA is promulgating a federal implementation plan (FIP), as required following the partial disapproval, to establish a PSD permitting program in Texas for GHG-emitting sources. EPA is taking this action through interim final rulemaking, effective upon publication, to ensure the availability of a permitting authority-- EPA--in Texas for GHG-emitting sources when they become subject to PSD on January 2, 2011. This will allow those sources to proceed with plans to construct or expand. This rule will expire on April 30, 2011. EPA is also proposing a notice-and-comment rulemaking that mirrors this rulemaking.

40 CFR 52.1241 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Minnesota § 52.1241 Interstate pollutant... owner and operator of each SO2 source located within the State of Minnesota and for which requirements... Administrator of a revision to the Minnesota State Implementation Plan as meeting the requirements of CAIR for...

40 CFR 52.1241 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2014 CFR

2014-07-01

...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Minnesota § 52.1241 Interstate pollutant... owner and operator of each SO2 source located within the State of Minnesota and for which requirements... Administrator of a revision to the Minnesota State Implementation Plan as meeting the requirements of CAIR for...

40 CFR 52.1241 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2011 CFR

2011-07-01

...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Minnesota § 52.1241 Interstate pollutant... owner and operator of each SO2 source located within the State of Minnesota and for which requirements... Administrator of a revision to the Minnesota State Implementation Plan as meeting the requirements of CAIR for...

40 CFR 52.1241 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2010 CFR

2010-07-01

...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Minnesota § 52.1241 Interstate pollutant... owner and operator of each SO2 source located within the State of Minnesota and for which requirements... Administrator of a revision to the Minnesota State Implementation Plan as meeting the requirements of CAIR for...

40 CFR 52.1241 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2013 CFR

2013-07-01

...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Minnesota § 52.1241 Interstate pollutant... owner and operator of each SO2 source located within the State of Minnesota and for which requirements... Administrator of a revision to the Minnesota State Implementation Plan as meeting the requirements of CAIR for...

40 CFR 52.1684 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2010 CFR

2010-07-01

...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) New York § 52.1684 Interstate pollutant...) The owner and operator of each source located within the State of New York and for which requirements... Administrator of a revision to the New York State Implementation Plan (SIP) as meeting the requirements of CAIR...

Accomplishments and economic evaluations of the Forestry Incentives Program: A review

Treesearch

Deborah A. Gaddis; Barry D. New; Fredrick W. Cubbage; Robert C. Abt; Robert J. Moulton

1995-01-01

The Forestry Incentives Program (FIP) is a federal financial cost-share program that is intended to increase the nation's timber supply by increasing tree planting and timber stand improvement on nonindustrial private forest lands. Timber harvest reductions on public lands in the West, environmental constraints on private lands throughout the U.S., and increased...

77 FR 35287 - Approval and Promulgation of Air Quality Implementation Plans; Virginia; Regional Haze State...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-13

... meeting the infrastructure requirements relating to visibility protection for the 1997 8-hour ozone...)(i)(II) and 110 (a)(2)(J), relating to visibility protection for the 1997 8-hour ozone NAAQS and the... Regional Haze SIP cannot lawfully discharge or restart the clock on a FIP obligation because EPA is already...

77 FR 42833 - Approval, Disapproval and Promulgation of Air Quality Implementation Plans; Arizona; Regional...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-20

... the problem of visibility impairment in Class I areas, states, or the EPA when implementing a FIP... explanation and rationale for its determinations. While we find these problems in all of ADEQ's BART analyses... problems resulted in control determinations that are inconsistent with the RHR and the BART Guidelines. We...

40 CFR 52.2588 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2010 CFR

2010-07-01

...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Wisconsin § 52.2588 Interstate pollutant... and operator of each SO2 source located within the State of Wisconsin and for which requirements are... revision to the Wisconsin State Implementation Plan as meeting the requirements of CAIR for PM2.5 relating...

40 CFR 52.2588 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2012 CFR

2012-07-01

...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Wisconsin § 52.2588 Interstate pollutant... owner and operator of each SO2 source located within the State of Wisconsin and for which requirements... Administrator of a revision to the Wisconsin State Implementation Plan as meeting the requirements of CAIR for...

40 CFR 52.2588 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2014 CFR

2014-07-01

...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Wisconsin § 52.2588 Interstate pollutant... owner and operator of each SO2 source located within the State of Wisconsin and for which requirements... Administrator of a revision to the Wisconsin State Implementation Plan as meeting the requirements of CAIR for...

40 CFR 52.2588 - Interstate pollutant transport provisions; What are the FIP requirements for decreases in...

Code of Federal Regulations, 2011 CFR

2011-07-01

...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Wisconsin § 52.2588 Interstate pollutant... and operator of each SO2 source located within the State of Wisconsin and for which requirements are... revision to the Wisconsin State Implementation Plan as meeting the requirements of CAIR for PM2.5 relating...

21 CFR 1311.115 - Additional requirements for two-factor authentication.

Code of Federal Regulations, 2012 CFR

2012-04-01

...) separate from the computer to which the practitioner is gaining access. (b) If one factor is a hard token, it must be separate from the computer to which it is gaining access and must meet at least the criteria of FIPS 140-2 Security Level 1, as incorporated by reference in § 1311.08, for cryptographic...

21 CFR 1311.115 - Additional requirements for two-factor authentication.

Code of Federal Regulations, 2010 CFR

2010-04-01

...) separate from the computer to which the practitioner is gaining access. (b) If one factor is a hard token, it must be separate from the computer to which it is gaining access and must meet at least the criteria of FIPS 140-2 Security Level 1, as incorporated by reference in § 1311.08, for cryptographic...

21 CFR 1311.115 - Additional requirements for two-factor authentication.

Code of Federal Regulations, 2013 CFR

2013-04-01

...) separate from the computer to which the practitioner is gaining access. (b) If one factor is a hard token, it must be separate from the computer to which it is gaining access and must meet at least the criteria of FIPS 140-2 Security Level 1, as incorporated by reference in § 1311.08, for cryptographic...

21 CFR 1311.115 - Additional requirements for two-factor authentication.

Code of Federal Regulations, 2014 CFR

2014-04-01

...) separate from the computer to which the practitioner is gaining access. (b) If one factor is a hard token, it must be separate from the computer to which it is gaining access and must meet at least the criteria of FIPS 140-2 Security Level 1, as incorporated by reference in § 1311.08, for cryptographic...

21 CFR 1311.115 - Additional requirements for two-factor authentication.

Code of Federal Regulations, 2011 CFR

2011-04-01

...) separate from the computer to which the practitioner is gaining access. (b) If one factor is a hard token, it must be separate from the computer to which it is gaining access and must meet at least the criteria of FIPS 140-2 Security Level 1, as incorporated by reference in § 1311.08, for cryptographic...

78 FR 62509 - Approval of Air Quality Implementation Plans; Navajo Nation; Regional Haze Requirements for...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-22

... Retrofit Technology (BART) provision of the Clean Air Act (CAA or Act). EPA proposed the BART FIP to reduce... included in the proposal due to the unique purpose and history of NGS and the numerous stakeholder... Use I. National Technology Transfer and Advancement Act J. Executive Order 12898: Federal Actions To...

Fe/O ratio variations during the disturbed stage in the development of the solar cosmic ray fluxes: Manifestations of the first ionization potential effect in the solar cosmic ray composition

NASA Astrophysics Data System (ADS)

Minasyants, G. S.; Minasyants, T. M.; Tomozov, V. M.

2016-03-01

The accelerated particle energy spectra in different energy intervals (from 0.06 to 75.69 MeV n-1) have been constructed for various powerful flare events (1997-2006) with the appearance of solar cosmic rays (SCRs) based on the processing of data from the Advanced Composition Explorer (ACE) and WIND spacecraft. Flares were as a rule accompanied by coronal mass ejections. Different specific features in the particle spectra behavior, possibly those related to different acceleration processes, were revealed when the events developed. The Fe/O abundance ratio in different energy intervals during the disturbed development of flareinduced fluxes has been qualitatively estimated. It has been established that ground level event (GLE) fluxes represent an individual subclass of gradual events according to the character of Fe/O variations. The manifestations of the first ionization potential (FIP) effect in the composition of SCRs during their propagation have been qualitatively described.

p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding.

PubMed

Itakura, Eisuke; Mizushima, Noboru

2011-01-10

Autophagy is an intracellular degradation process by which cytoplasmic contents are degraded in the lysosome. In addition to nonselective engulfment of cytoplasmic materials, the autophagosomal membrane can selectively recognize specific proteins and organelles. It is generally believed that the major selective substrate (or cargo receptor) p62 is recruited to the autophagosomal membrane through interaction with LC3. In this study, we analyzed loading of p62 and its related protein NBR1 and found that they localize to the endoplasmic reticulum (ER)-associated autophagosome formation site independently of LC3 localization to membranes. p62 colocalizes with upstream autophagy factors such as ULK1 and VMP1 even when autophagosome formation is blocked by wortmannin or FIP200 knockout. Self-oligomerization of p62 is essential for its localization to the autophagosome formation site. These results suggest that p62 localizes to the autophagosome formation site on the ER, where autophagosomes are nucleated. This process is similar to the yeast cytoplasm to vacuole targeting pathway.

77 FR 64908 - Extension of Administrative Stay; Approval and Promulgation of Implementation Plans; New Mexico...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-24

... the Administrative Procedure Act (APA). EPA previously stayed this rule for 90 days, from July 16... Pursuant to section 705 of the APA, the EPA hereby extends the existing administrative stay of the... obligations under the terms of the NM FIP that arise during the 135 day period. Under section 705 of the APA...

21 CFR 1311.30 - Requirements for storing and using a private key for digitally signing orders.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Requirements for storing and using a private key... Digital Certificates for Electronic Orders § 1311.30 Requirements for storing and using a private key for... and private key. (b) The certificate holder must provide FIPS-approved secure storage for the private...

21 CFR 1311.30 - Requirements for storing and using a private key for digitally signing orders.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 9 2014-04-01 2014-04-01 false Requirements for storing and using a private key... Certificates for Electronic Orders § 1311.30 Requirements for storing and using a private key for digitally... private key. (b) The certificate holder must provide FIPS-approved secure storage for the private key, as...

21 CFR 1311.30 - Requirements for storing and using a private key for digitally signing orders.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 9 2012-04-01 2012-04-01 false Requirements for storing and using a private key... Certificates for Electronic Orders § 1311.30 Requirements for storing and using a private key for digitally... private key. (b) The certificate holder must provide FIPS-approved secure storage for the private key, as...

21 CFR 1311.30 - Requirements for storing and using a private key for digitally signing orders.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 9 2011-04-01 2011-04-01 false Requirements for storing and using a private key... Certificates for Electronic Orders § 1311.30 Requirements for storing and using a private key for digitally... private key. (b) The certificate holder must provide FIPS-approved secure storage for the private key, as...

21 CFR 1311.30 - Requirements for storing and using a private key for digitally signing orders.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 9 2013-04-01 2013-04-01 false Requirements for storing and using a private key... Certificates for Electronic Orders § 1311.30 Requirements for storing and using a private key for digitally... private key. (b) The certificate holder must provide FIPS-approved secure storage for the private key, as...

40 CFR 52.35 - What are the requirements of the Federal Implementation Plans (FIPs) for the Clean Air Interstate...

Code of Federal Regulations, 2014 CFR

2014-07-01

... nitrogen oxides? 52.35 Section 52.35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... (CAIR) relating to emissions of nitrogen oxides? (a)(1) The Federal CAIR NOX Annual Trading Program... provisions that relate to annual emissions of nitrogen oxides (NOX). Each State that is described in § 51.123...

40 CFR 52.35 - What are the requirements of the Federal Implementation Plans (FIPs) for the Clean Air Interstate...

Code of Federal Regulations, 2012 CFR

2012-07-01

... nitrogen oxides? 52.35 Section 52.35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... (CAIR) relating to emissions of nitrogen oxides? (a)(1) The Federal CAIR NOX Annual Trading Program... provisions that relate to annual emissions of nitrogen oxides (NOX). Each State that is described in § 51.123...

40 CFR 52.35 - What are the requirements of the Federal Implementation Plans (FIPs) for the Clean Air Interstate...

Code of Federal Regulations, 2010 CFR

2010-07-01

... nitrogen oxides? 52.35 Section 52.35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... (CAIR) relating to emissions of nitrogen oxides? (a)(1) The Federal CAIR NOX Annual Trading Program... provisions that relate to annual emissions of nitrogen oxides (NOX). Each State that is described in § 51.123...

40 CFR 52.35 - What are the requirements of the Federal Implementation Plans (FIPs) for the Clean Air Interstate...

Code of Federal Regulations, 2011 CFR

2011-07-01

... nitrogen oxides? 52.35 Section 52.35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... (CAIR) relating to emissions of nitrogen oxides? (a)(1) The Federal CAIR NOX Annual Trading Program... provisions that relate to annual emissions of nitrogen oxides (NOX). Each State that is described in § 51.123...

40 CFR 52.35 - What are the requirements of the Federal Implementation Plans (FIPs) for the Clean Air Interstate...

Code of Federal Regulations, 2013 CFR

2013-07-01

... nitrogen oxides? 52.35 Section 52.35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... (CAIR) relating to emissions of nitrogen oxides? (a)(1) The Federal CAIR NOX Annual Trading Program... provisions that relate to annual emissions of nitrogen oxides (NOX). Each State that is described in § 51.123...

Elevated Suicide Rates at High Altitude: Sociodemographic and Health Issues May Be to Blame

ERIC Educational Resources Information Center

Betz, Marian E.; Valley, Morgan A.; Lowenstein, Steven R.; Hedegaard, Holly; Thomas, Deborah; Stallones, Lorann; Honigman, Benjamin

2011-01-01

Suicide rates are higher at high altitudes; some hypothesize that hypoxia is the cause. We examined 8,871 suicides recorded in 2006 in 15 states by the National Violent Death Reporting System, with the victim's home county altitude determined from the National Elevation Dataset through FIPS code matching. We grouped cases by altitude (low less…

77 FR 72511 - Approval, Disapproval and Promulgation of Air Quality Implementation Plans; Arizona; Regional...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-05

... Consulting & Research, Inc. (57) The initials RMC mean or refer to Regional Modeling Center. (58) The... whether an alternative test method to the one required in the SIP is acceptable for PM 10. In addition, we..., we allow the use of Method 5 as an alternative to Method 201A/202. In addition, the FIP includes a...

77 FR 24793 - Approval and Promulgation of Air Quality Implementation Plans; State of New York; Regional Haze...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-25

..., and remedy any existing, man-made impairment of visibility in mandatory Class I areas caused by....regulations.gov Web site is an ``anonymous access'' system, which means EPA will not know your identity or...: Table of Contents I. What action is EPA proposing? A. Proposed Actions B. SIP and FIP Background C...

Molecular drug targets in myeloproliferative neoplasms: mutant ABL1, JAK2, MPL, KIT, PDGFRA, PDGFRB and FGFR1

PubMed Central

Tefferi, Ayalew

2009-01-01

Abstract Therapeutically validated oncoproteins in myeloproliferative neoplasms (MPN) include BCR-ABL1 and rearranged PDGFR proteins. The latter are products of intra- (e.g. FIP1L1-PDGFRA) or inter-chromosomal (e.g.ETV6-PDGFRB) gene fusions. BCR-ABL1 is associated with chronic myelogenous leukaemia (CML) and mutant PDGFR with an MPN phenotype characterized by eosinophilia and in addition, in case of FIP1L1-PDGFRA, bone marrow mastocytosis. These genotype-phenotype associations have been effectively exploited in the development of highly accurate diagnostic assays and molecular targeted therapy. It is hoped that the same will happen in other MPN with specific genetic alterations: polycythemia vera (JAK2V617F and other JAK2 mutations), essential thrombocythemia (JAK2V617F and MPL515 mutations), primary myelofibrosis (JAK2V617F and MPL515 mutations), systemic mastocytosis (KITD816V and other KIT mutations) and stem cell leukaemia/lymphoma (ZNF198-FGFR1 and other FGFR1 fusion genes). The current review discusses the above-listed mutant molecules in the context of their value as drug targets. PMID:19175693

In Vitro Antiviral Activity of Circular Triple Helix Forming Oligonucleotide RNA towards Feline Infectious Peritonitis Virus Replication

PubMed Central

Choong, Oi Kuan; Tejo, Bimo Ario; Omar, Abdul Rahman

2014-01-01

Feline Infectious Peritonitis (FIP) is a severe fatal immune-augmented disease in cat population. It is caused by FIP virus (FIPV), a virulent mutant strain of Feline Enteric Coronavirus (FECV). Current treatments and prophylactics are not effective. The in vitro antiviral properties of five circular Triple-Helix Forming Oligonucleotide (TFO) RNAs (TFO1 to TFO5), which target the different regions of virulent feline coronavirus (FCoV) strain FIPV WSU 79-1146 genome, were tested in FIPV-infected Crandell-Rees Feline Kidney (CRFK) cells. RT-qPCR results showed that the circular TFO RNAs, except TFO2, inhibit FIPV replication, where the viral genome copy numbers decreased significantly by 5-fold log10 from 1014 in the virus-inoculated cells to 109 in the circular TFO RNAs-transfected cells. Furthermore, the binding of the circular TFO RNA with the targeted viral genome segment was also confirmed using electrophoretic mobility shift assay. The strength of binding kinetics between the TFO RNAs and their target regions was demonstrated by NanoITC assay. In conclusion, the circular TFOs have the potential to be further developed as antiviral agents against FIPV infection. PMID:24707494

Mutations in the Fusion Protein of Measles Virus That Confer Resistance to the Membrane Fusion Inhibitors Carbobenzoxy-d-Phe-l-Phe-Gly and 4-Nitro-2-Phenylacetyl Amino-Benzamide

PubMed Central

Ha, Michael N.; Delpeut, Sébastien; Noyce, Ryan S.; Sisson, Gary; Black, Karen M.; Lin, Liang-Tzung; Bilimoria, Darius; Plemper, Richard K.; Privé, Gilbert G.

2017-01-01

ABSTRACT The inhibitors carbobenzoxy (Z)-d-Phe-l-Phe-Gly (fusion inhibitor peptide [FIP]) and 4-nitro-2-phenylacetyl amino-benzamide (AS-48) have similar efficacies in blocking membrane fusion and syncytium formation mediated by measles virus (MeV). Other homologues, such as Z-d-Phe, are less effective but may act through the same mechanism. In an attempt to map the site of action of these inhibitors, we generated mutant viruses that were resistant to the inhibitory effects of Z-d-Phe-l-Phe-Gly. These 10 mutations were localized to the heptad repeat B (HRB) region of the fusion protein, and no changes were observed in the viral hemagglutinin, which is the receptor attachment protein. Mutations were validated in a luciferase-based membrane fusion assay, using transfected fusion and hemagglutinin expression plasmids or with syncytium-based assays in Vero, Vero-SLAM, and Vero-Nectin 4 cell lines. The changes I452T, D458N, D458G/V459A, N462K, N462H, G464E, and I483R conferred resistance to both FIP and AS-48 without compromising membrane fusion. The inhibitors did not block hemagglutinin protein-mediated binding to the target cell. Edmonston vaccine/laboratory and IC323 wild-type strains were equally affected by the inhibitors. Escape mutations were mapped upon a three-dimensional (3D) structure modeled from the published crystal structure of parainfluenzavirus 5 fusion protein. The most effective mutations were situated in a region located near the base of the globular head and its junction with the alpha-helical stalk of the prefusion protein. We hypothesize that the fusion inhibitors could interfere with the structural changes that occur between the prefusion and postfusion conformations of the fusion protein. IMPORTANCE Due to lapses in vaccination worldwide that have caused localized outbreaks, measles virus (MeV) has regained importance as a pathogen. Antiviral agents against measles virus are not commercially available but could be useful in conjunction with MeV eradication vaccine programs and as a safeguard in oncolytic viral therapy. Three decades ago, the small hydrophobic peptide Z-d-Phe-l-Phe-Gly (FIP) was shown to block MeV infections and syncytium formation in monkey kidney cell lines. The exact mechanism of its action has yet to be determined, but it does appear to have properties similar to those of another chemical inhibitor, AS-48, which appears to interfere with the conformational change in the viral F protein that is required to elicit membrane fusion. Escape mutations were used to map the site of action for FIP. Knowledge gained from these studies could help in the design of new inhibitors against morbilliviruses and provide additional knowledge concerning the mechanism of virus-mediated membrane fusion. PMID:28904193

Report of Official Foreign Travel to Germany, May 16-June 1, 2001

DOE Office of Scientific and Technical Information (OSTI.GOV)

J. D. Mason

2001-06-18

The Department of Energy (DOE) and associated agencies have moved rapidly toward electronic production, management, and dissemination of scientific and technical information. The World-Wide Web (WWW) has become a primary means of information dissemination. Electronic commerce (EC) is becoming the preferred means of procurement. DOE, like other government agencies, depends on and encourages the use of international standards in data communications. Like most government agencies, DOE has expressed a preference for openly developed standards over proprietary designs promoted as ''standards'' by vendors. In particular, there is a preference for standards developed by organizations such as the International Organization for Standardizationmore » (ISO) and the American National Standards Institute (ANSI) that use open, public processes to develop their standards. Among the most widely adopted international standards is the Standard Generalized Markup Language (SGML, ISO 8879:1986, FIPS 152), to which DOE long ago made a commitment. Besides the official commitment, which has resulted in several specialized projects, DOE makes heavy use of coding derived from SGML: Most documents on the WWW are coded in HTML (Hypertext Markup Language), which is an application of SGML. The World-Wide Web Consortium (W3C), with the backing of major software houses like Adobe, IBM, Microsoft, Netscape, Oracle, and Sun, is promoting XML (eXtensible Markup Language), a class of SGML applications, for the future of the WWW and the basis for EC. In support of DOE's use of these standards, I have served since 1985 as Chairman of the international committee responsible for SGML and related standards, ISO/IEC JTC1/SC34 (SC34) and its predecessor organizations. During my May 2001 trip, I chaired the spring 2001 meeting of SC34 in Berlin, Germany. I also attended XML Europe 2001, a major conference on the use of SGML and XML sponsored by the Graphic Communications Association (GCA), and chaired a meeting of the International SGML/XML Users' Group (ISUG). In addition to the widespread use of the WWW among DOE's plants and facilities in Oak Ridge and among DOE sites across the nation, there have been several past and present SGML- and XML-based projects at the Y-12 National Security Complex (Y-12). Our local project team has done SGML and XML development at Y-12 and Oak Ridge National Laboratory (ORNL) since the late 1980s. SGML is a component of the Weapons Records Archiving and Preservation (WRAP) project at Y-12 and is the format for catalog metadata chosen for weapons records by the Nuclear Weapons Information Group (NWIG). The ''Ferret'' system for automated classification analysis uses XML to structure its knowledge base. The Ferret team also provides XML consulting to OSTI and DOE Headquarters, particularly the National Nuclear Security Administration (NNSA). Supporting standards development allows DOE and Y-12 the opportunity both to provide input into the process and to benefit from contact with some of the leading experts in the subject matter. Oak Ridge has been for some years the location to which other DOE sites turn for expertise in SGML, XML, and related topics.« less

hydroPSO: A Versatile Particle Swarm Optimisation R Package for Calibration of Environmental Models

NASA Astrophysics Data System (ADS)

Zambrano-Bigiarini, M.; Rojas, R.

2012-04-01

Particle Swarm Optimisation (PSO) is a recent and powerful population-based stochastic optimisation technique inspired by social behaviour of bird flocking, which shares similarities with other evolutionary techniques such as Genetic Algorithms (GA). In PSO, however, each individual of the population, known as particle in PSO terminology, adjusts its flying trajectory on the multi-dimensional search-space according to its own experience (best-known personal position) and the one of its neighbours in the swarm (best-known local position). PSO has recently received a surge of attention given its flexibility, ease of programming, low memory and CPU requirements, and efficiency. Despite these advantages, PSO may still get trapped into sub-optimal solutions, suffer from swarm explosion or premature convergence. Thus, the development of enhancements to the "canonical" PSO is an active area of research. To date, several modifications to the canonical PSO have been proposed in the literature, resulting into a large and dispersed collection of codes and algorithms which might well be used for similar if not identical purposes. In this work we present hydroPSO, a platform-independent R package implementing several enhancements to the canonical PSO that we consider of utmost importance to bring this technique to the attention of a broader community of scientists and practitioners. hydroPSO is model-independent, allowing the user to interface any model code with the calibration engine without having to invest considerable effort in customizing PSO to a new calibration problem. Some of the controlling options to fine-tune hydroPSO are: four alternative topologies, several types of inertia weight, time-variant acceleration coefficients, time-variant maximum velocity, regrouping of particles when premature convergence is detected, different types of boundary conditions and many others. Additionally, hydroPSO implements recent PSO variants such as: Improved Particle Swarm Optimisation (IPSO), Fully Informed Particle Swarm (FIPS), and weighted FIPS (wFIPS). Finally, an advanced sensitivity analysis using the Latin Hypercube One-At-a-Time (LH-OAT) method and user-friendly plotting summaries facilitate the interpretation and assessment of the calibration/optimisation results. We validate hydroPSO against the standard PSO algorithm (SPSO-2007) employing five test functions commonly used to assess the performance of optimisation algorithms. Additionally, we illustrate how the performance of the optimization/calibration engine is boosted by using several of the fine-tune options included in hydroPSO. Finally, we show how to interface SWAT-2005 with hydroPSO to calibrate a semi-distributed hydrological model for the Ega River basin in Spain, and how to interface MODFLOW-2000 and hydroPSO to calibrate a groundwater flow model for the regional aquifer of the Pampa del Tamarugal in Chile. We limit the applications of hydroPSO to study cases dealing with surface water and groundwater models as these two are the authors' areas of expertise. However, based on the flexibility of hydroPSO we believe this package can be implemented to any model code requiring some form of parameter estimation.

Rab11 family expression in the human placenta: Localization at the maternal-fetal interface

PubMed Central

Artemiuk, Patrycja A.; Hanscom, Sara R.; Lindsay, Andrew J.; Wuebbolt, Danielle; Breathnach, Fionnuala M.; Tully, Elizabeth C.; Khan, Amir R.; McCaffrey, Mary W.

2017-01-01

Rab proteins are a family of small GTPases involved in a variety of cellular processes. The Rab11 subfamily in particular directs key steps of intracellular functions involving vesicle trafficking of the endosomal recycling pathway. This Rab subfamily works through a series of effector proteins including the Rab11-FIPs (Rab11 Family-Interacting Proteins). While the Rab11 subfamily has been well characterized at the cellular level, its function within human organ systems is still being explored. In an effort to further study these proteins, we conducted a preliminary investigation of a subgroup of endosomal Rab proteins in a range of human cell lines by Western blotting. The results from this analysis indicated that Rab11a, Rab11c(Rab25) and Rab14 were expressed in a wide range of cell lines, including the human placental trophoblastic BeWo cell line. These findings encouraged us to further analyse the localization of these Rabs and their common effector protein, the Rab Coupling Protein (RCP), by immunofluorescence microscopy and to extend this work to normal human placental tissue. The placenta is a highly active exchange interface, facilitating transfer between mother and fetus during pregnancy. As Rab11 proteins are closely involved in transcytosis we hypothesized that the placenta would be an interesting human tissue model system for Rab investigation. By immunofluorescence microscopy, Rab11a, Rab11c(Rab25), Rab14 as well as their common FIP effector RCP showed prominent expression in the placental cell lines. We also identified the expression of these proteins in human placental lysates by Western blot analysis. Further, via fluorescent immunohistochemistry, we noted abundant localization of these proteins within key functional areas of primary human placental tissues, namely the outer syncytial layer of placental villous tissue and the endothelia of fetal blood vessels. Overall these findings highlight the expression of the Rab11 family within the human placenta, with novel localization at the maternal-fetal interface. PMID:28922401

Survival, growth, and body residues of Hyalella azteca (Saussure) exposed to fipronil contaminated sediments from non-vegetated and vegetated microcosms

USDA-ARS?s Scientific Manuscript database

We assessed chronic effects of fipronil and metabolite contaminated sediments from non-vegetated and Thallia dealbata vegetated wetland microcosms on Hyalella azteca during wet and dry exposures. Mean sediment concentrations (ng g-1) ranged from 0.72-1.26, 0.01-0.69, 0.07-0.23, and 0.49-7.87 for fip...

Seroprevalence study of feline coronavirus in owned and feral cats in Sydney, Australia.

PubMed

Bell, E T; Toribio, J A L M L; White, J D; Malik, R; Norris, J M

2006-03-01

i) To establish the seroprevalence of Feline Coronavirus (FCoV) infection in two defined groups of cats in Sydney: owned and feral cats; ii) to identify factors associated with an increased risk of infection with FCoV; and iii) to establish the seroprevalence and FCoV antibody titres of owned cats with immunohistochemically confirmed feline infectious peritonitis (FIP). Prospective multi-institutional cross sectional study. Procedure Serum samples from owned cats presented to three inner city veterinary clinics in Sydney and feral cats from a colony in South Western Sydney over an 11-month period were tested for FCoV antibodies using the Immunocomb test kit. The relationship between serological score and six major factors (breed, age, gender, number of cats per household, living environment and health status) in the owned cat sample population was analysed and compared to cats with FIR RESULTS: The seroprevalence of FCoV infection in the sample population of owned and feral cats was 34% and 0%, respectively. The median Immunocomb scores of DSH, Persian, Siamese and Devon Rex cats were significantly lower than that of Burmese, BSH, Abyssinian, Birman, Ragdoll and Russian Blue. The median lmmunocomb score of pedigree cats less than 2 years-of-age was significantly higher than for pedigree cats greater than 2 years-of-age. This distinction was not evident in DSH cats in these age groups. The number of cats per household at the time of blood collection had a strong positive association with Immunocomb score. The median Immunocomb score of cats with immunohistochemically confirmed FIP was significantly higher than cats in the sample population of owned cats but there was sufficient overlap between these two groups to make definitive diagnosis of FIP by serology impossible. This represents the first seroprevalence study of FCoV in Australia. The major determinants of antibody score of owned cats identified in this study were breed, age and the number of cats per household. The significant relationship between the breed of the cat and the FCoV antibody titre further supports the notion, proposed previously by the authors, that breed related differences exist in the immunological response to FCoV infection.

NEON AND OXYGEN ABUNDANCES AND ABUNDANCE RATIO IN THE SOLAR CORONA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Landi, E.; Testa, P., E-mail: elandi@umich.edu

2015-02-20

In this work we determine the Ne/O abundance ratio from Solar and Heliospheric Observatory (SOHO)/Solar Ultraviolet Measurement of Emitted Radiation (SUMER) off-disk observations of quiescent streamers over the 1996-2008 period. We find that the Ne/O ratio is approximately constant over solar cycle 23 from 1996 to 2005, at a value of 0.099 ± 0.017; this value is lower than the transition region determinations from the quiet Sun used to infer the neon photospheric abundance from the oxygen photospheric abundance. Also, the Ne/O ratio we determined from SUMER is in excellent agreement with in situ determinations from ACE/SWICS. In 2005-2008, the Ne/O abundancemore » ratio increased with time and reached 0.25 ± 0.05, following the same trend found in the slowest wind analyzed by ACE/SWICS. Further, we measure the absolute abundance in the corona for both oxygen and neon from the data set of 1996 November 22, obtaining A {sub o} = 8.99 ± 0.04 and A {sub Ne} = 7.92 ± 0.03, and we find that both elements are affected by the first ionization potential (FIP) effect, with oxygen being enhanced by a factor of 1.4-2.1 over its photospheric abundance, and neon being changed by a factor of 0.75-1.20. We conclude that the Ne/O ratio is not constant in the solar atmosphere, both in time and at different heights, and that it cannot be reliably used to infer the neon abundance in the photosphere. Also, we argue that the FIP effect was less effective during the minimum of solar cycle 24, and that the Ne/O = 0.25 ± 0.05 value measured at that time is closer to the true photospheric value, leading to a neon photospheric abundance larger than assumed by ≈40%. We discuss the implications of these results for the solar abundance problem, for the FIP effect, and for the identification of the source regions of the solar wind.« less

How Many Words Does a Picture Really Tell? Cross-sectional Descriptive Study of Pictogram Evaluation by Youth

PubMed Central

Korenevsky, Artyom; Vaillancourt, Régis; Pouliot, Annie; Revol, Marine; Steed, Evan; Besançon, Luc; Wahrendorf, Marit-Saskia; Patel, Jaimisha R

2013-01-01

Background Communicating health-related instructions with pictograms is useful, but such graphics can be interpreted in different ways. It is crucial to understand which pictogram components are best for accurate communication. Objectives: To catalogue pictograms used to label drugs in clinical practice; to identify the common graphic elements for defined categories of pictograms, by performing a semiotic analysis (studying how signs are perceived and how they should be designed); to identify the key graphic elements common to pictograms preferred by users; and to develop suggestions for future pictogram design on the basis of users’ input. Methods: Literature and Internet searches were performed to identify pictograms and pictogram categories. A call for pictograms was also circulated through the International Pharmaceutical Federation (FIP). Youth at a Canadian pediatric hospital were asked to rate pictograms (including storyboards and prescription labels generated by FIP pictogram software) in terms of how best they represented their intended meanings. Pictograms for which at least 80% of participants “somewhat agreed”, “agreed”, or “strongly agreed” that the graphic conveyed the intended meaning were designated as “preferred” and were selected for analysis. Elements appearing in at least 50% of these preferred pictograms were highlighted as key graphic elements for design of future pictograms. Results: In total, 21 categories were identified for pictograms used in clinical practice, and a total of 204 pictograms were analyzed. Eighty-six participants took part in the survey. For each pictogram category, certain elements were identified as “preferred” and as “key graphic elements”, whereas other elements met neither designation. For all 21 pictogram categories, at least 80% of survey respondents agreed that the FIP storyboard conveyed the intended meaning. Conclusions: Certain key, preferred graphic elements are required for pharmaceutical pictograms to convey their intended meaning. The overlap between preferred and key pictogram elements indicates that both must be considered in development of future pictograms. Redesign of existing pictograms with consideration of the best semiotic elements is in progress. PMID:23950605

Developing material for promoting problem-solving ability through bar modeling technique

NASA Astrophysics Data System (ADS)

Widyasari, N.; Rosiyanti, H.

2018-01-01

This study aimed at developing material for enhancing problem-solving ability through bar modeling technique with thematic learning. Polya’s steps of problem-solving were chosen as the basis of the study. The methods of the study were research and development. The subject of this study were five teen students of the fifth grade of Lab-school FIP UMJ elementary school. Expert review and student’ response analysis were used to collect the data. Furthermore, the data were analyzed using qualitative descriptive and quantitative. The findings showed that material in theme “Selalu Berhemat Energi” was categorized as valid and practical. The validity was measured by using the aspect of language, contents, and graphics. Based on the expert comments, the materials were easy to implement in the teaching-learning process. In addition, the result of students’ response showed that material was both interesting and easy to understand. Thus, students gained more understanding in learning problem-solving.

Unmanned Tactical Autonomous Control and Collaboration Threat and Vulnerability Assessment

DTIC Science & Technology

2015-06-01

they are evaluated separately 15 from each other [19]. One major difference between this classification method and the FIPS 199 is that no...both technical and nontechnical methods ” [31]. These different methods will enable the UTACC system to effectively mitigate vulnerabilities that...team. Marines on the battlefield communicate with each other in many different and unique methods . UTACC must be adaptable to these different methods

Coso MT Site Locations

DOE Data Explorer

Doug Blankenship

2011-05-04

This data includes the locations of the MT data collected in and around the Coso Geothermal field that covered the West Flank area. These are the data that the 3D MT models were created from that were discussed in Phase 1 of the West Flank FORGE project. The projected coordinate system is NAD 1927 State Plane California IV FIPS 0404 and the Projection is Lambert Conformal Conic. Units are in feet.

Parental Age and Risk of Autism Spectrum Disorders in a Finnish National Birth Cohort

ERIC Educational Resources Information Center

Lampi, Katja M.; Hinkka-Yli-Salomäki, Susanna; Lehti, Venla; Helenius, Hans; Gissler, Mika; Brown, Alan S.; Sourander, Andre

2013-01-01

Aim of the study was to examine the associations between parental age and autism spectrum disorders (ASD). Data were based on the FIPS-A (Finnish Prenatal Study of Autism and Autism Spectrum Disorders), a case-control study with a total of 4,713 cases with childhood autism (n = 1,132), Asperger's syndrome (n = 1,785) or other pervasive…

Reconstructing Ancient Egyptian Diet through Bone Elemental Analysis Using LIBS (Qubbet el Hawa Cemetery)

PubMed Central

Al-Khafif, Ghada Darwish; El-Banna, Rokia

2015-01-01

One of the most important advantages of LIBS that make it suitable for the analysis of archeological materials is that it is a quasi-nondestructive technique. Archeological mandibles excavated from Qubbet el Hawa Cemetery, Aswan, were subjected to elemental analysis in order to reconstruct the dietary patterns of the middle class of the Aswan population throughout three successive eras: the First Intermediate Period (FIP), the Middle Kingdom (MK), and the Second Intermediate Period (SIP). The bone Sr/Ca and Ba/Ca ratios were significantly correlated, so the Sr/Ca ratios are considered to represent the ante-mortem values. It was suggested that the significantly low FIP Sr/Ca compared to that of both the MK and the SIP was attributed to the consumption of unusual sorts of food and imported cereals during years of famine, while the MK Sr/Ca was considered to represent the amelioration of climatic, social, economic, and political conditions in this era of state socialism. The SIP Sr/Ca, which is nearly the same as that of the MK, was considered to be the reflection of the continuity of the individualism respect and state socialism and a reflection of agriculture conditions amelioration under the reign of the 17th Dynasty in Upper Egypt. PMID:26345727

Models of Cosmic-Ray Origin

NASA Astrophysics Data System (ADS)

Shapiro, M. M.

2001-08-01

Two models of cosmic-ray genesis are compared: (a) the author s red-dwarf hypothesis requiring the injection of seed particles from coronal mass ejections (CME) prior to shock acceleration, and (b) the direct acceleration of thermal ions and of grains in the ISM, proposed by Meyer, Drury and Ellison. Both models agree that shocks in the expanding envelopes of supernova remnants are principally responsible for acceleration to cosmic-ray energies. Both are designed to overcome the mismatch between the source composition of the Galactic cosmic rays (GCR) and the composition of the thermal ISM gas. Model (a) utilizes the prolific emissions of energetic particles from active dMe and dKe stars via their CME as the agents of seed-particle injection into the ISM. The composition of these seed particles is governed by the FIP (first-ionization potential) selection mechanism that operates for both Galactic cosmic rays and solar energetic particles. Hence it is consistent with the cosmic-ray source composition. Model (b) relies on the sputtering and acceleration of grains in the ISM (along with acceleration of thermal ions) to provide the known source composition. This model considers the FIP ordering of GCR abundances as purely coincidental, and it attributes the relative source abundances to selection according to volatility. Recent cosmic-ray observations in favor of each model are cited.

Demonstration of feline corona virus (FCV) antigen in organs of cats suspected of feline infectious peritonitis (FIP) disease.

PubMed

Hök, K

1990-07-01

Cryosections of organs and smears from membrana nicitians from cats suspected of having spontaneous infection with feline infectious peritonitis virus (FIPV), were investigated using an indirect immunofluorescence assay (IIFA) in order to detect the presence of feline corona virus (FCV). In 113 cats, from each of which six organs were screened, virus antigen was found most often in membrana nicitians and lung. Out of these animals an additional six organs from a group of 30 cats were screened. In these cats membrana nicitians, parotid gland, thymus and apex of caecum had the highest incidence of virus antigen (90%). The lowest incidence of virus antigen was found in the spleen (60%). There was a clear demonstration of a higher incidence of antigen present in more than half of the total number of screened organs per cat (P less than 0.0005). No statistical difference was observed between sexes when comparing the incidence of virus antigen in different organs. Virus antigen was present in less organs in cats with no lesions suggestive of FIP disease compared to cats with such lesions (P less than 0.001). A similar distribution of the incidence of FCV antigen in the investigated organs was observed in these two groups.

Approaches to education of pharmaceutical biotechnology in faculties of pharmacy.

PubMed

Calis, S; Oner, F; Kas, S; Hincal, A A

2001-06-01

Pharmaceutical biotechnology is developing rapidly both in academic institutions and in the biopharmaceutical industry. For this reason, FIP Special Interest Group of Pharmaceutical Biotechnology decided to develop a questionnaire concerning pharmaceutical biotechnology education. After preliminary studies were completed, questionnaires were sent to the leading scientists in academia and research directors or senior managers of various Pharmaceutical Biotechnology Companies in order to gather their views about how to create a satisfactory program. The objectives of this study were as follows: -To review all of the graduate and undergraduate courses which are presently available worldwide on pharmaceutical biotechnology in Faculties of Pharmacy. -To review all of the text books, references and scientific sources available worldwide in the area of pharmaceutical biotechnology. When replying to the questionnaires, the respondents were asked to consider the present status of pharmaceutical biotechnology education in academia and future learning needs in collaboration with the biotechnology industry. The data from various pharmacy faculties and biotechnology industry representatives from Asia, Europe and America were evaluated and the outcome of the survey showed that educational efforts in training qualified staff in the rapidly growing field of pharmaceutical biotechnology is promising. Part of the results of this questionnaire study have already been presented at the 57th International Congress of FIP Vancouver, Canada in 1997.

Linking microcracks and mineral zoning of detachment-exhumed granites to their tectonomagmatic history: Evidence from the Salihli and Turgutlu plutons in western Turkey (Menderes Massif)

NASA Astrophysics Data System (ADS)

Catlos, Elizabeth J.; Baker, Courteney B.; Sorensen, Sorena S.; Jacob, Lauren; Çemen, Ibrahim

2011-05-01

The Menderes Massif (western Turkey) is a metamorphic core complex that displays linked syntectonic plutonism and detachment faulting. Fabrics in S-type peraluminous granites (Salihli and Turgutlu) in the detachment (Alaşehir) footwall change from isotropic to protomylonitic to mylonitic towards the structure. Samples from the isotropic and protomylonitic zones were imaged in transmitted light, cathodoluminescence (CL), backscattered (BSE), and secondary electrons (SE), and show that these rocks contain abundant microcracks, and that plagioclase grains have zoning consistent with magma mixing. The granites contain fluid inclusion planes (FIPs), myrmekite replacing plagioclase, and the removal of blue luminescence in K-feldspar along microcracks and grain boundaries. Calcite and hydrous minerals commonly fill microcracks. The samples record features that formed due to (1) magma crystallization and ductile deformation (FIPs, mineral zoning), (2) changes in P and/or T (impingement and stress-induced microcracks in protomylonitic rocks), and (3) differences in intrinsic mineral properties (radial, cleavage, blunted, and deflected microcracks). Overprinted microcracks indicate exhumation during pulses. The Middle Miocene ages of these granites reported elsewhere are similar to those from large-scale extensional structures in Greece's Cycladic Massif. The Menderes and Cycladic core complexes may have developed simultaneously due to the widespread intrusion of subduction-related granitoids.

Folding Proteins at 500 ns/hour with Work Queue.

PubMed

Abdul-Wahid, Badi'; Yu, Li; Rajan, Dinesh; Feng, Haoyun; Darve, Eric; Thain, Douglas; Izaguirre, Jesús A

2012-10-01

Molecular modeling is a field that traditionally has large computational costs. Until recently, most simulation techniques relied on long trajectories, which inherently have poor scalability. A new class of methods is proposed that requires only a large number of short calculations, and for which minimal communication between computer nodes is required. We considered one of the more accurate variants called Accelerated Weighted Ensemble Dynamics (AWE) and for which distributed computing can be made efficient. We implemented AWE using the Work Queue framework for task management and applied it to an all atom protein model (Fip35 WW domain). We can run with excellent scalability by simultaneously utilizing heterogeneous resources from multiple computing platforms such as clouds (Amazon EC2, Microsoft Azure), dedicated clusters, grids, on multiple architectures (CPU/GPU, 32/64bit), and in a dynamic environment in which processes are regularly added or removed from the pool. This has allowed us to achieve an aggregate sampling rate of over 500 ns/hour. As a comparison, a single process typically achieves 0.1 ns/hour.

Folding Proteins at 500 ns/hour with Work Queue

PubMed Central

Abdul-Wahid, Badi’; Yu, Li; Rajan, Dinesh; Feng, Haoyun; Darve, Eric; Thain, Douglas; Izaguirre, Jesús A.

2014-01-01

Molecular modeling is a field that traditionally has large computational costs. Until recently, most simulation techniques relied on long trajectories, which inherently have poor scalability. A new class of methods is proposed that requires only a large number of short calculations, and for which minimal communication between computer nodes is required. We considered one of the more accurate variants called Accelerated Weighted Ensemble Dynamics (AWE) and for which distributed computing can be made efficient. We implemented AWE using the Work Queue framework for task management and applied it to an all atom protein model (Fip35 WW domain). We can run with excellent scalability by simultaneously utilizing heterogeneous resources from multiple computing platforms such as clouds (Amazon EC2, Microsoft Azure), dedicated clusters, grids, on multiple architectures (CPU/GPU, 32/64bit), and in a dynamic environment in which processes are regularly added or removed from the pool. This has allowed us to achieve an aggregate sampling rate of over 500 ns/hour. As a comparison, a single process typically achieves 0.1 ns/hour. PMID:25540799

Data Analysis of a Space Experiment: Common Software Tackles Uncommon Task

NASA Technical Reports Server (NTRS)

Wilkinson, R. Allen

1998-01-01

Presented here are the software adaptations developed by laboratory scientists to process the space experiment data products from three experiments on two International Microgravity Laboratory Missions (IML-1 and IML-2). The challenge was to accommodate interacting with many types of hardware and software developed by both European Space Agency (ESA) and NASA aerospace contractors, where data formats were neither commercial nor familiar to scientists. Some of the data had been corrupted by bit shifting of byte boundaries. Least-significant/most-significant byte swapping also occurred as might be expected for the various hardware platforms involved. The data consisted of 20 GBytes per experiment of both numerical and image data. A significant percentage of the bytes were consumed in NASA formatting with extra layers of packetizing structure. It was provided in various pieces to the scientists on magnetic tapes, Syquest cartridges, DAT tapes, CD-ROMS, analog video tapes, and by network FIP. In this paper I will provide some science background and present the software processing used to make the data useful in the months after the missions.

p62 targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding

PubMed Central

Itakura, Eisuke

2011-01-01

Autophagy is an intracellular degradation process by which cytoplasmic contents are degraded in the lysosome. In addition to nonselective engulfment of cytoplasmic materials, the autophagosomal membrane can selectively recognize specific proteins and organelles. It is generally believed that the major selective substrate (or cargo receptor) p62 is recruited to the autophagosomal membrane through interaction with LC3. In this study, we analyzed loading of p62 and its related protein NBR1 and found that they localize to the endoplasmic reticulum (ER)–associated autophagosome formation site independently of LC3 localization to membranes. p62 colocalizes with upstream autophagy factors such as ULK1 and VMP1 even when autophagosome formation is blocked by wortmannin or FIP200 knockout. Self-oligomerization of p62 is essential for its localization to the autophagosome formation site. These results suggest that p62 localizes to the autophagosome formation site on the ER, where autophagosomes are nucleated. This process is similar to the yeast cytoplasm to vacuole targeting pathway. PMID:21220506

FIELD IMPLEMENTATION PLAN FOR A WILLISTON BASIN BRINE EXTRACTION AND STORAGE TEST

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hamling, John; Klapperich, Ryan; Stepan, Daniel

2016-03-31

The Energy & Environmental Research Center (EERC) successfully completed all technical work of Phase I, including development of a field implementation plan (FIP) for a brine extraction and storage test (BEST) in the North Dakota portion of the Williston Basin. This implementation plan was commissioned by the U.S. Department of Energy (DOE) National Energy Technology Laboratory (NETL) as a proxy for managing formation pressure plumes and measuring/monitoring the movement of differential pressure and CO2 plumes in the subsurface for future saline CO2 storage projects. BEST comprises the demonstration and validation of active reservoir management (ARM) strategies and extracted brine treatmentmore » technologies. Two prospective commercial brine injection sites were evaluated for BEST to satisfy DOE’s goals. Ultimately, an active saltwater disposal (SWD) site, Johnsons Corner, was selected because it possesses an ideal combination of key factors making it uniquely suited to host BEST. This site is located in western North Dakota and operated by Nuverra Environmental Solutions (Nuverra), a national leader in brine handling, treatment, and injection. An integrated management approach was used to incorporate local and regional geologic characterization activities with geologic and simulation models, inform a monitoring, verification, and accounting (MVA) plan, and to conduct a risk assessment. This approach was used to design a FIP for an ARM schema and an extracted brine treatment technology test bed facility. The FIP leverages an existing pressure plume generated by two commercial SWD wells. These wells, in conjunction with a new brine extraction well, will be used to conduct the ARM schema. Results of these tests will be quantified based on their impact on the performance of the existing SWD wells and the surrounding reservoir system. Extracted brine will be injected into an underlying deep saline formation through a new injection well. The locations of proposed extraction and injection wells were selected during the Phase I efforts. These wells will be permitted as North Dakota Administrative Code Underground Injection Control Class II wells and will yield additional characterization data which will further refine the FIP in Phase II. An array of surface and downhole monitoring techniques will validate ARM performance against predictive simulation results. Infrastructure will be constructed to manage extracted fluids at the surface and provide brine to a treatment test bed facility. Treatment of extracted brine can provide a means of reducing extracted brine disposal volumes, an alternate source of water, and/or salable products for beneficial use. A test bed facility will be constructed to provide a means of demonstrating these technologies on a wide range of brine concentrations. Screening criteria based on a techno-economic and life cycle assessment were developed to select high-salinity brine treatment technologies for extended duration treatment (30–60 days) in Phase II. A detailed cost assessment determined total implementation costs for BEST of $19,901,065 million (DOE share $15,680,505). These costs are inclusive of all necessary equipment, infrastructure construction, operations and project closeout costs required to implement BEST. An ideal combination of key factors makes the Johnsons Corner site uniquely suited to be the BEST demonstration.« less

Predicting county-level cancer incidence rates and counts in the United States

PubMed Central

Yu, Binbing

2018-01-01

Many countries, including the United States, publish predicted numbers of cancer incidence and death in current and future years for the whole country. These predictions provide important information on the cancer burden for cancer control planners, policymakers and the general public. Based on evidence from several empirical studies, the joinpoint (segmented-line linear regression) model has been adopted by the American Cancer Society to estimate the number of new cancer cases in the United States and in individual states since 2007. Recently, cancer incidence in smaller geographic regions such as counties and FIPS code regions is of increasing interest by local policymakers. The natural extension is to directly apply the joinpoint model to county-level cancer incidence data. The direct application has several drawbacks and its performance has not been evaluated. To address the concerns, we developed a spatial random-effects joinpoint model for county-level cancer incidence data. The proposed model was used to predict both cancer incidence rates and counts at the county level. The standard joinpoint model and the proposed method were compared through a validation study. The proposed method out-performed the standard joinpoint model for almost all cancer sites, especially for moderate or rare cancer sites and for counties with small population sizes. As an application, we predicted county-level prostate cancer incidence rates and counts for the year 2011 in Connecticut. PMID:23670947

Investigating the Role of FIP200 in Mammary Carcinogenesis Using a Transgenic Mouse Model

DTIC Science & Technology

2006-04-01

I analyzed virgin and lactating female mice in which FAK is specifically deleted in the mammary epithelium. No morphological abnormalities were found...in the mammary gland of virgin mice however, lactating mice have severe lobulo-alveolar hypoplasia in the mammary gland. 15. SUBJECT TERMS... virgin and lactating female mice in which FAK is specifically deleted in the mammary epithelium. No morphological abnormalities were found in the

Investigating the Role of FIP200 in Mammary Carcinogenesis Using a Transgenic Mouse Model

DTIC Science & Technology

2007-04-01

analysis of virgin and lactating female mice in which FAK was specifically deleted in the mammary epithelium. No morphological abnormalities were found in...the mammary gland of virgin mice however, lactating mice have severe lobulo-alveolar hypoplasia in the mammary gland. After completing the analysis...were collected to prepare protein extracts. Organs were first snap-frozen in liquid nitrogen and then were ground using a mortar and a pestle

40 CFR 52.39 - What are the requirements of the Federal Implementation Plans (FIPs) for the Transport Rule (TR...

Code of Federal Regulations, 2013 CFR

2013-07-01

... June 1, 2013. 2016 June 1, 2014. 2017 June 1, 2014. 2018 June 1, 2015. 2019 June 1, 2015. 2020 and any... 1, 2014. 2017 June 1, 2014. 2018 June 1, 2015. 2019 June 1, 2015. 2020 and any year thereafter June... toadministrator 2014 June 1, 2013. 2015 June 1, 2013. 2016 June 1, 2014. 2017 June 1, 2014. 2018 June 1, 2015...

40 CFR 52.39 - What are the requirements of the Federal Implementation Plans (FIPs) for the Transport Rule (TR...

Code of Federal Regulations, 2012 CFR

2012-07-01

... June 1, 2013. 2016 June 1, 2014. 2017 June 1, 2014. 2018 June 1, 2015. 2019 June 1, 2015. 2020 and any... 1, 2014. 2017 June 1, 2014. 2018 June 1, 2015. 2019 June 1, 2015. 2020 and any year thereafter June.... 2019 June 1, 2015. 2020 and any year thereafter June 1 of the fourth year before the year of the...

Identification of JAK2 as a Mediator of FIP1L1-PDGFRA-Induced Eosinophil Growth and Function in CEL

PubMed Central

Li, Bin; Zhang, Guangsen; Li, Cui; He, Dan; Li, Xinying; Zhang, Chunfang; Tang, Faqing; Deng, Xiyun; Lu, Jingchen; Tang, Youhong; Li, Ruijuan; Chen, Zhuchu; Duan, Chaojun

2012-01-01

The Fip1-like1 (FIP1L1)-platelet-derived growth factor receptor alpha fusion gene (F/P) arising in the pluripotent hematopoietic stem cell (HSC),causes 14% to 60% of patients with hypereosinophilia syndrome (HES). These patients, classified as having F/P (+) chronic eosinophilic leukemia (CEL), present with clonal eosinophilia and display a more aggressive disease phenotype than patients with F/P (–) HES patients. The mechanisms underlying predominant eosinophil lineage targeting and the cytotoxicity of eosinophils in this leukemia remain unclear. Given that the Janus tyrosine kinase (JAK)/signal transducers and activators of transcription (Stat) signaling pathway is key to cytokine receptor-mediated eosinophil development and activated Stat3 and Stat5 regulate the expression of genes involved in F/P malignant transformation, we investigated whether and how JAK proteins were involved in the pathogenesis of F/P-induced CEL. F/P activation of JAK2, Stat3 and Stat5, were confirmed in all the 11 F/P (+) CEL patients examined. In vitro inhibition of JAK2 in EOL-1, primary F/P(+) CEL cells (PC) and T674I F/P Imatinib resistant cells(IR) by either JAK2-specific short interfering RNA (siRNA) or the tryphostin derivative AG490(AG490), significantly reduced cellular proliferation and induced cellular apoptosis. The F/P can enhance the IL-5-induced JAK2 activation, and further results indicated that JAK2 inhibition blocked IL-5-induced cellular migration and activation of the EOL-1 and PC cells in vitro. F/P-stimulation of the JAK2 suppressed cells led to a significantly reduction in Stat3 activation, but relatively normal induction of Stat5 activation. Interestingly, JAK2 inhibition also reduced PI3K, Akt and NF-κB activity in a dose-dependent manner, and suppressed expression levels of c-Myc and Survivin. These results strongly suggest that JAK2 is activated by F/P and is required for F/P stimulation of cellular proliferation and infiltration, possibly through induction of c-Myc and Survivin expression via activation of multiple signaling pathways, including NF-κB, Stat3, and PI3K/Akt. PMID:22523564

The First Ionization Potential Effect from the Ponderomotive Force: On the Polarization and Coronal Origin of Alfvén Waves

NASA Astrophysics Data System (ADS)

Laming, J. Martin

2017-08-01

We investigate in more detail the origin of chromospheric Alfvén waves that give rise to the separation of ions and neutrals—the first ionization potential (FIP) effect—through the action of the ponderomotive force. In open field regions, we model the dependence of fractionation on the plasma upflow velocity through the chromosphere for both shear (or planar) and torsional Alfvén waves of photospheric origin. These differ mainly in their parametric coupling to slow mode waves. Shear Alfvén waves appear to reproduce observed fractionations for a wider range of model parameters and present less of a “fine-tuning” problem than do torsional waves. In closed field regions, we study the fractionations produced by Alfvén waves with photospheric and coronal origins. Waves with a coronal origin, at or close to resonance with the coronal loop, offer a significantly better match to observed abundances than do photospheric waves, with shear and torsional waves in such a case giving essentially indistinguishable fractionations. Such coronal waves are likely the result of a nanoflare coronal heating mechanism that, as well as heating coronal plasmas, releases Alfvén waves that can travel down to loop footpoints and cause FIP fractionation through the ponderomotive force as they reflect from the chromosphere back into the corona.

The First Ionization Potential Effect from the Ponderomotive Force: On the Polarization and Coronal Origin of Alfvén Waves

DOE Office of Scientific and Technical Information (OSTI.GOV)

Laming, J. Martin, E-mail: laming@nrl.navy.mil

We investigate in more detail the origin of chromospheric Alfvén waves that give rise to the separation of ions and neutrals—the first ionization potential (FIP) effect—through the action of the ponderomotive force. In open field regions, we model the dependence of fractionation on the plasma upflow velocity through the chromosphere for both shear (or planar) and torsional Alfvén waves of photospheric origin. These differ mainly in their parametric coupling to slow mode waves. Shear Alfvén waves appear to reproduce observed fractionations for a wider range of model parameters and present less of a “fine-tuning” problem than do torsional waves. Inmore » closed field regions, we study the fractionations produced by Alfvén waves with photospheric and coronal origins. Waves with a coronal origin, at or close to resonance with the coronal loop, offer a significantly better match to observed abundances than do photospheric waves, with shear and torsional waves in such a case giving essentially indistinguishable fractionations. Such coronal waves are likely the result of a nanoflare coronal heating mechanism that, as well as heating coronal plasmas, releases Alfvén waves that can travel down to loop footpoints and cause FIP fractionation through the ponderomotive force as they reflect from the chromosphere back into the corona.« less

A study of amplitude information-frequency characteristics for underwater active electrolocation system.

PubMed

Peng, Jiegang

2015-11-04

Weakly electric fish sense their surroundings in complete darkness by their active electrolocation system. For biologists, the active electrolocation system has been investigated for near 60 years. And for engineers, bio-inspired active electrolocation sensor has been investigated for about 20 years. But how the amplitude information response will be affected by frequencies of detecting electric fields in the active electrolocation system was rarely investigated. In this paper, an electrolocation experiment system has been built. The amplitude information-frequency characteristics (AIFC) of the electrolocation system for sinusoidal electric fields of varying frequencies have been investigated. We find that AIFC of the electrolocation system have relevance to the material properties and geometric features of the probed object and conductivity of surrounding water. Detect frequency dead zone (DFDZ) and frequency inflection point (FIP) of AIFC for the electrolocation system were found. The analysis model of the electrolocation system has been investigated for many years, but DFDZ and FIP of AIFC can be difficult to explain by those models. In order to explain those AIFC phenomena for the electrolocation system, a simple relaxation model based on Cole-Cole model which is not only a mathematical explanation but it is a physical one for the electrolocation system was advanced. We also advance a hypothesis for physical mechanism of weakly electrical fish electrolocation system. It may have reference value for physical mechanism of weakly electrical fish active electrolocation system.

The Freshwater Information Platform - an online network supporting freshwater biodiversity research and policy

NASA Astrophysics Data System (ADS)

Schmidt-Kloiber, Astrid; De Wever, Aaike; Bremerich, Vanessa; Strackbein, Jörg; Hering, Daniel; Jähnig, Sonja; Kiesel, Jens; Martens, Koen; Tockner, Klement

2017-04-01

Species distribution data is crucial for improving our understanding of biodiversity and its threats. This is especially the case for freshwater environments, which are heavily affected by the global biodiversity crisis. Currently, a huge body of freshwater biodiversity data is often difficult to access, because systematic data publishing practices have not yet been adopted by the freshwater research community. The Freshwater Information Platform (FIP; www.freshwaterplatform.eu) - initiated through the BioFresh project - aims at pooling freshwater related research information from a variety of projects and initiatives to make it easily accessible for scientists, water managers and conservationists as well as the interested public. It consists of several major components, three of which we want to specifically address: (1) The Freshwater Biodiversity Data Portal aims at mobilising freshwater biodiversity data, making them online available Datasets in the portal are described and documented in the (2) Freshwater Metadatabase and published as open access articles in the Freshwater Metadata Journal. The use of collected datasets for large-scale analyses and models is demonstrated in the (3) Global Freshwater Biodiversity Atlas that publishes interactive online maps featuring research results on freshwater biodiversity, resources, threats and conservation priorities. Here we present the main components of the FIP as tools to streamline open access freshwater data publication arguing this will improve the capacity to protect and manage freshwater biodiversity in the face of global change.

Ponderomotive Acceleration in Coronal Loops

NASA Astrophysics Data System (ADS)

Dahlburg, Russell B.; Laming, J. Martin; Taylor, Brian; Obenschain, Keith

2017-08-01

Ponderomotive acceleration has been asserted to be a cause of the First Ionization Potential (FIP) effect, the by now well known enhancement in abundance by a factor of 3-4 over photospheric values of elements in the solar corona with FIP less than about 10 eV. It is shown here by means of numerical simulations that ponderomotive acceleration occurs in solar coronal loops, with the appropriate magnitude and direction, as a ``byproduct'' of coronal heating. The numerical simulations are performed with the HYPERION code, which solves the fully compressible three-dimensional magnetohydrodynamic equations including nonlinear thermal conduction and optically thin radiation. Numerical simulations of a coronal loops with an axial magnetic field from 0.005 Teslas to 0.02 Teslas and lengths from 25000 km to 75000 km are presented. In the simulations the footpoints of the axial loop magnetic field are convected by random, large-scale motions. There is a continuous formation and dissipation of field-aligned current sheets which act to heat the loop. As a consequence of coronal magnetic reconnection, small scale, high speed jets form. The familiar vortex quadrupoles form at reconnection sites. Between the magnetic footpoints and the corona the reconnection flow merges with the boundary flow. It is in this region that the ponderomotive acceleration occurs. Mirroring the character of the coronal reconnection, the ponderomotive acceleration is also found to be intermittent.

Biorelevant in vitro performance testing of orally administered dosage forms-workshop report.

PubMed

Reppas, Christos; Friedel, Horst-Dieter; Barker, Amy R; Buhse, Lucinda F; Cecil, Todd L; Keitel, Susanne; Kraemer, Johannes; Morris, J Michael; Shah, Vinod P; Stickelmeyer, Mary P; Yomota, Chikako; Brown, Cynthia K

2014-07-01

Biorelevant in vitro performance testing of orally administered dosage forms has become an important tool for the assessment of drug product in vivo behavior. An in vitro performance test which mimics the intraluminal performance of an oral dosage form is termed biorelevant. Biorelevant tests have been utilized to decrease the number of in vivo studies required during the drug development process and to mitigate the risk related to in vivo bioequivalence studies. This report reviews the ability of current in vitro performance tests to predict in vivo performance and generate successful in vitro and in vivo correlations for oral dosage forms. It also summarizes efforts to improve the predictability of biorelevant tests. The report is based on the presentations at the 2013 workshop, Biorelevant In Vitro Performance Testing of Orally Administered Dosage Forms, in Washington, DC, sponsored by the FIP Dissolution/Drug Release Focus Group in partnership with the American Association of Pharmaceutical Scientists (AAPS) and a symposium at the AAPS 2012 Annual meeting on the same topic.

How autophagy eats large mitochondria: Autophagosome formation coupled with mitochondrial fragmentation.

PubMed

Yamashita, Shun-Ichi; Kanki, Tomotake

2017-05-04

Mitochondrial autophagy (mitophagy) is thought to be a multi-step pathway wherein mitochondria are first divided into small fragments, which are subsequently recognized by the phagophore. DNM1L (dynamin 1 like) plays a pivotal role in mitochondrial division; however, its role in mitophagy remains controversial. In our recent study, we examined the contribution of DNM1L to mitophagy and showed that mitophagy and mitochondrial division occur even in DNM1L-defective cells. Furthermore, time-lapse imaging of mitophagy showed that DNM1L-independent mitochondrial division occurs concomitantly with autophagosome formation. Upstream factors of autophagosome formation, i.e., RB1CC1/FIP200, ATG14, and WIPIs, are required for mitochondrial division, whereas ATG5 and ATG3 are dispensable. These results indicate that a portion of the tubular mitochondria is first recognized and then divided into small fragments by a phagophore-mediated event, independently of DNM1L. This autophagic process suggests that autophagy has the potential to degrade substrates larger than autophagosomes.

Fungal immunomodulatory proteins in the context of biomedicine.

PubMed

Uribe-Echeverry, Paula Tatiana; Lopez-Gartner, German Ariel

2017-06-01

Fungi represent a large group of biodiverse microorganisms with potential applications ranging from industrial fields to the treatment for human diseases. A large number of pharmacologically active compounds including terpenoids, polysaccharides and proteins have been derived from these microorganisms. Fungal Immunomodulatory Proteins (FIPs) are a group of active compounds that are being considered for the treatment of asthma, allergy, autoimmune diseases and cancer. Here, we discuss the discovery, heterologous production bioactive mechanisms of action and their potential use in biomedicine.

Current Challenges and Potential Opportunities for the Pharmaceutical Sciences to Make Global Impact: An FIP Perspective.

PubMed

Tucker, Geoffrey; DeSilva, Binodh; Dressman, Jennifer; Ito, Michiho; Kumamoto, Takuya; Mager, Don; Mahler, Hanns-Christian; Maitland-van der Zee, Anke H; Pauletti, Giovanni M; Sasaki, Hitoshi; Shah, Vinod; Tang, Daniel; Ward, Michael

2016-09-01

The chairs of each of the 8 Special Interest Groups of the Board of Pharmaceutical Sciences of the International Pharmaceutical Federation have compiled opinions with regard to major challenges for the pharmaceutical sciences over the next 5-10 years. Areas covered are drug design and discovery, natural products, formulation design and pharmaceutical technology, pharmacokinetics/pharmacodynamics and systems pharmacology, translational and personalized medicine, biotechnology, analytical sciences and quality control, and regulatory science. Copyright © 2016. Published by Elsevier Inc.

PS-FW: A Hybrid Algorithm Based on Particle Swarm and Fireworks for Global Optimization

PubMed Central

Chen, Shuangqing; Wei, Lixin; Guan, Bing

2018-01-01

Particle swarm optimization (PSO) and fireworks algorithm (FWA) are two recently developed optimization methods which have been applied in various areas due to their simplicity and efficiency. However, when being applied to high-dimensional optimization problems, PSO algorithm may be trapped in the local optima owing to the lack of powerful global exploration capability, and fireworks algorithm is difficult to converge in some cases because of its relatively low local exploitation efficiency for noncore fireworks. In this paper, a hybrid algorithm called PS-FW is presented, in which the modified operators of FWA are embedded into the solving process of PSO. In the iteration process, the abandonment and supplement mechanism is adopted to balance the exploration and exploitation ability of PS-FW, and the modified explosion operator and the novel mutation operator are proposed to speed up the global convergence and to avoid prematurity. To verify the performance of the proposed PS-FW algorithm, 22 high-dimensional benchmark functions have been employed, and it is compared with PSO, FWA, stdPSO, CPSO, CLPSO, FIPS, Frankenstein, and ALWPSO algorithms. Results show that the PS-FW algorithm is an efficient, robust, and fast converging optimization method for solving global optimization problems. PMID:29675036

Report of Official foreign Travel to Spain April 17-29, 1999. (in English;)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mason, j.d.

The Department of Energy (DOE) has moved rapidly toward electronic production, management, and dissemination of scientific and technical information. The World-Wide Web (WWW) has become a primary means of information dissemination. Electronic commerce (EC) is becoming the preferred means of procurement. DOE, like other government agencies, depends on and encourages the use of international standards in data communications. Like most government agencies, DOE has expressed a preference for openly developed standards in preference to proprietary designs promoted as "standards" by vendors. In particular, there is a preference for standards developed by organizations such as the International Organization for Standardization (ISO)more » and the American National Standards Institute (ANSI) that use open, public processes to develop their standards. Among the most widely adopted international standards is the Standard Generalized Markup Language (SGML, ISO 8879:1986, FIPS 152), which DOE has selected as the basis of its electronic management of documents. Besides the official commitment, which has resulted in several specialized projects, DOE makes heavy use of coding derived from SGML, and its use is likely to increase in the future. Most documents on the WWW are coded in HTML ("Hypertext Markup Language"), which is an application of SGML. The World-Wide Web Consortium (W3C), with the backing of major software houses like Microsoft, Adobe, and Netscape, is promoting XML ("eXtensible Markup Language"), a class of SGML applications, for the future of the WWW and the basis for EC. W3C has announced its intention of discontinuing future development of HTML and replacing it with XHTML, an application of XML. In support of DOE's use of these standards, I have served since 1985 as Chairman of the international committee responsible for SGML and related standards, ISO/IEC JTC1/SC34 (SC34) and its predecessor organizations. During my April 1999 trip, I convened the spring 1999 meeting of SC34 in Granada, Spain. I also attended a major conference on the use of SGML and XML. SC34 maintains and continues to enhance several standards. In addition to SGML, which is the basis of HTML and XML, SC34 also works on the Document Style Semantics and Specification Language (DSSSL), which is the basis for W3C's XSL ("eXtensible Style Language," to be used with XML) and the Hypermedia/Time-based Document Structuring Language (HyTime), which is a major influence on W3C's XLink ("XML Linking Language"). SC34 is also involved in work with ISO's TC184, Industrial Data, on the linking of STEP (the standard for the interchange of product model data) with SGML. In addition to the widespread use of the WWW among DOE's plants and facilities in Oak Ridge and among DOE sites across the nation, there are several SGML-based projects at the Y-12 Plant. My project team in Information Technology Services developed an SGML-based publications system that has been used for several major reports at the Y-12 Plant and Oak Ridge National Laboratory (ORNL). SGML is a component of the Weapons Records Archiving and Preservation (WRAP) project at the Y-12 Plant and is the format for catalog metadata chosen for weapons records by the Nuclear Weapons Information Group (NWIG). Supporting standards development allows DOE and the Y-12 plant both input into the process and the opportunity to benefit from contact with some of the leading experts in the subject matter. Oak Ridge has been for some years the location to which other DOE sites turn for expertise in SGML and related topics.« less

FIP effect for minor heavy solar wind ions as seen with SOHO/CELIAS/MTOF

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heidrich-Meisner, Verena, E-mail: heidrich@physik.uni-kiel.de; Berger, Lars; Wimmer-Schweingruber, Robert F.

A recent paper [Shearer et al., 2014] reported that during solar maximum Ne showed a surprisingly low abundance. This leads to the question whether other elements show the same behavior. The good mass resolution of Mass-Time-Of-Flight (MTOF) as part of the Charge ELement and Isotope Analysis System (CELIAS) on the Solar Helioshperic Observatory (SOHO) allows to investigate the composition of heavy minor elements in different types of solar wind. We restrict this study to slow solar wind, where the characterisation of slow solar wind is taken from Xu and Borovsky, 2014. This classification scheme requires magnet field information. Since SOHOmore » does not carry a magnetometer, we use the Magnetometer (MAG) of the Advanced Composition Explorer (ACE) instead. The Solar Wind Ion Composition Spectrometer (ACE/SWICS) also provides composition data for cross-calibration and charge-state distributions as input for the transmission function of MTOF whenever the two spacecraft can be expected to observe the same type of wind. We illustrate the MTOF’s capability to determine the solar wind abundance compared to the photospheric abundance (called the FIP ratio in the following) for rare elements like Ti or Cr on long-time scales as a proof of concept for our analysis. And in this brief study, measurements with both ACE/SWICS indicate that the observed elements exhibit a (weak) dependence on the solar cycle, whereas the MTOF measurements are inconclusive.« less

Element Abundance Ratios in the Quiet Sun Transition Region

NASA Astrophysics Data System (ADS)

Young, P. R.

2018-03-01

Element abundance ratios of magnesium to neon (Mg/Ne) and neon to oxygen (Ne/O) in the transition region of the quiet Sun have been derived by re-assessing previously published data from the Coronal Diagnostic Spectrometer on board the Solar and Heliospheric Observatory in the light of new atomic data. The quiet Sun Mg/Ne ratio is important for assessing the effect of magnetic activity on the mechanism of the first ionization potential (FIP) effect, while the Ne/O ratio can be used to infer the solar photospheric abundance of neon, which cannot be measured directly. The average Mg/Ne ratio is found to be 0.52 ± 0.11, which applies over the temperature region 0.2–0.7 MK, and is consistent with the earlier study. The Ne/O ratio is, however, about 40% larger, taking the value 0.24 ± 0.05 that applies to the temperature range 0.08–0.40 MK. The increase is mostly due to changes in ionization and recombination rates that affect the equilibrium ionization balance. If the Ne/O ratio is interpreted as reflecting the photospheric ratio, then the photospheric neon abundance is 8.08 ± 0.09 or 8.15 ± 0.10 (on a logarithmic scale for which hydrogen is 12), according to whether the oxygen abundances of M. Asplund et al. or E. Caffau et al. are used. The updated photospheric neon abundance implies a Mg/Ne FIP bias for the quiet Sun of 1.6 ± 0.6.

The Joint NASA/Goddard-University of Maryland Research Program in Charged Particle and High Energy Photon Detector Technology

NASA Technical Reports Server (NTRS)

Ipavich, F. M.

1990-01-01

The Univ. of Maryland portion investigated the following areas. The Space Physics Group performed studies of data from the AMPTE/CCE spacecraft CHEM experiment and found that the ratio of solar wind to photospheric abundances decreased rather smoothly with the first ionization potential (FIP) of the ion with the low FIP ion being about a factor of two overabundant. Carbon and hydrogen fit this trend particularly well. Several occurrences were analyzed of field aligned beams observed when CCE was upstream of the Earth's bow shock. Also using CHEM data, ring current intensity and composition changes during the main and recovery phases of the great geomagnetic storm that occurred in February 1986 was examined in detail. Still using CHEM data, ring current characteristics were examined in a survey of 20 magnetic storms ranging in size from -50 nT to -312 nT. A study was done of energetic ion anisotropy characteristics in the Earth's magnetosheath region using data from the UMD/MPE experiment on ISEE-1. The properties were analyzed of approx. 30 to 130 keV/e protons and alpha particles upstream of six quasi-parallel interplanetary shocks that passed by the ISEE-3 spacecraft during 1978 to 1979. Work from NASA-Goddard include studies from the High Energy Cosmic Ray Group, Low Energy Cosmic Ray Group, Low Energy Gamma Ray Group, High Energy Astrophysics Theory Group, and the X ray Astronomy Group.

CrossTalk: The Journal of Defense Software Engineering. Volume 20, Number 5, May 2007

DTIC Science & Technology

2007-05-01

zation Program. Washington: GSA, DoD, and NASA , 2005 <http:// www.arnet.gov/far/>. 11. Department of Commerce. NIST. FIPS Pub 200, Minimum Security...on this Web site. The NASA Goddard Space Flight Center (GSFC) SwA http://sw-assurance.gsfc.nasa.gov The NASA GSFC SwA Web site pro- vides tools...OCT2006 c STAR WARS TO STAR TREK NOV2006 c MANAGEMENT BASICS DEC2006 c REQUIREMENTS ENG. JAN2007 c PUBLISHER’S CHOICE FEB2007 c CMMI MAR2007 c

Modified Betatron Accelerator Studies.

DTIC Science & Technology

1983-12-01

extraction ports. 29 14 Combined negative mass and beam breakup instability growth rates (solid curves) for t - 13 and Be - 2 kG. Growth of the negative...a stable beam equilibrium 0 for the duration of the acceleration period, typically thousands of revolu- tions; and (c) extraction of the beam, which...bom extraction , it was felt that it would be premature to start work eI I’l 1r a S - - Fip’S .1IU~V~~’ f mdifedbetO coflCPt’ The ajo radius of U tS W

Rab11a and its binding partners regulate the recycling of the β1-adrenergic receptor

PubMed Central

Gardner, Lidia A.; Hajjhussein, Hassan; Frederick, Katherine C.; Bahouth, Suleiman W.

2010-01-01

β1-adrenergic receptors (β1-AR) are internalized in response to agonists and then recycle back for another round of signaling. The serine 312 to alanine mutant of the β1-AR (S312A) is internalized but does not recycle. We determined that WT β1-AR and S312A were internalized initially to an early sorting compartment because they colocalized by >70% with the early endosomal markers rab5a and early endosomal antigen-1 (EEA1). Subsequently, the WT β1-AR trafficked via rab4a-expressing sorting endosomes to recycling endosomes. In recycling endosomes WT β1-AR were colocalized by >70% with the rab11 GTPase. S312A did not colocalize with either rab4a or rab11, instead they exited from early endosomes to late endosomes/lysosomes in which they were degraded. Rab11a played a prominent role in recycling of the WT β1-AR because dominant negative rab11a inhibited, while constitutively active rab11a accelerated the recycling of the β1-AR. Next, we determined the effect of each of the rab11-intercating proteins on trafficking of the WT β1-AR. The recycling of the β1-AR was markedly inhibited when myosin Vb, FIP2, FIP3 and rabphillin were knocked down. These data indicate that rab11a and a select group of its binding partners play a prominent role recycling of the human β1-AR. PMID:20727405

Detecting negative ions on board small satellites

NASA Astrophysics Data System (ADS)

Lepri, S. T.; Raines, J. M.; Gilbert, J. A.; Cutler, J.; Panning, M.; Zurbuchen, T. H.

2017-04-01

Recent measurements near comets, planets, and their satellites have shown that heavy ions, energetic neutral atoms, molecular ions, and charged dust contain a wealth of information about the origin, evolution, and interaction of celestial bodies with their space environment. Using highly sensitive plasma instruments, positively charged heavy ions have been used to trace exospheric and surface composition of comets, planets, and satellites as well as the composition of interplanetary and interstellar dust. While positive ions dominate throughout the heliosphere, negative ions are also produced from surface interactions. In fact, laboratory experiments have shown that oxygen released from rocky surfaces is mostly negatively charged. Negative ions and negatively charged nanograins have been detected with plasma electron analyzers in several different environments (e.g., by Cassini and Rosetta), though more extensive studies have been challenging without instrumentation dedicated to negative ions. We discuss an adaptation of the Fast Imaging Plasma Spectrometer (FIPS) flown on MErcury Surface, Space ENvironment, GEochemistry and Ranging (MESSENGER) for the measurement of negatively charged particles. MESSENGER/FIPS successfully measured the plasma environment of Mercury from 2011 until 2015, when the mission ended, and has been used to map multiple ion species (H+ through Na+ and beyond) throughout Mercury's space environment. Modifications to the existing instrument design fits within a 3U CubeSat volume and would provide a low mass, low power instrument, ideal for future CubeSat or distributed sensor missions seeking, for the first time, to characterize the contribution of negative particles in the heliospheric plasmas near the planets, moons, comets, and other sources.

Utility of feline coronavirus antibody tests.

PubMed

Addie, Diane D; le Poder, Sophie; Burr, Paul; Decaro, Nicola; Graham, Elizabeth; Hofmann-Lehmann, Regina; Jarrett, Oswald; McDonald, Michael; Meli, Marina L

2015-02-01

Eight different tests for antibodies to feline coronavirus (FCoV) were evaluated for attributes that are important in situations in veterinary practice. We compared four indirect immunofluorescent antibody tests (IFAT), one enzyme-linked immunosorbent assay (ELISA) (FCoV Immunocomb; Biogal) and three rapid immunochromatographic (RIM) tests against a panel of samples designated by consensus as positive or negative. Specificity was 100% for all but the two IFATs based on transmissible gastroenteritis virus (TGEV), at 83.3% and 97.5%. The IFAT and ELISA tests were best for obtaining an antibody titre and for working in the presence of virus. The RIM tests were the best for obtaining a result quickly (10-15 mins); of these, the Speed F-Corona was the most sensitive, at 92.4%, followed by FASTest feline infectious peritonitis (FIP; 84.6%) and Anigen Rapid FCoV antibody test (64.1%). Sensitivity was 100% for the ELISA, one FCoV IFAT and one TGEV IFAT; and 98.2% for a second TGEV IFA and 96.1% for a second FCoV IFAT. All tests worked with effusions, even when only blood products were stipulated in the instruction manual. The ELISA and Anigen RIM tests were best for small quantities of sample. The most appropriate FCoV antibody test to use depends on the reason for testing: in excluding a diagnosis of FIP, sensitivity, specificity, small sample quantity, rapidity and ability to work in the presence of virus all matter. For FCoV screening, speed and sensitivity are important, and for FCoV elimination antibody titre is essential. © ISFM and AAFP 2014.

Correlation of Coronal Plasma Properties and Solar Magnetic Field in a Decaying Active Region

NASA Technical Reports Server (NTRS)

Ko, Yuan-Kuen; Young, Peter R.; Muglach, Karin; Warren, Harry P.; Ugarte-Urra, Ignacio

2016-01-01

We present the analysis of a decaying active region observed by the EUV Imaging Spectrometer on Hinode during 2009 December 7-11. We investigated the temporal evolution of its structure exhibited by plasma at temperatures from 300,000 to 2.8 million degrees, and derived the electron density, differential emission measure, effective electron temperature, and elemental abundance ratios of Si/S and Fe/S (as a measure of the First Ionization Potential (FIP) Effect). We compared these coronal properties to the temporal evolution of the photospheric magnetic field strength obtained from the Solar and Heliospheric Observatory Michelson Doppler Imager magnetograms. We find that, while these coronal properties all decreased with time during this decay phase, the largest change was at plasma above 1.5 million degrees. The photospheric magnetic field strength also decreased with time but mainly for field strengths lower than about 70 Gauss. The effective electron temperature and the FIP bias seem to reach a basal state (at 1.5 x 10(exp 6) K and 1.5, respectively) into the quiet Sun when the mean photospheric magnetic field (excluding all areas <10 G) weakened to below 35 G, while the electron density continued to decrease with the weakening field. These physical properties are all positively correlated with each other and the correlation is the strongest in the high-temperature plasma. Such correlation properties should be considered in the quest for our understanding of how the corona is heated. The variations in the elemental abundance should especially be considered together with the electron temperature and density.

A small-molecule activator induces ULK1-modulating autophagy-associated cell death in triple negative breast cancer.

PubMed

Ouyang, Liang; Zhang, Lan; Fu, Leilei; Liu, Bo

2017-04-03

ULK1 (unc-51 like autophagy activating kinase 1) is well known to be required to initiate the macroautophagy/autophagy process, and thus activation of ULK1-modulating autophagy/autophagy-associated cell death (ACD) may be a possible therapeutic strategy in triple negative breast cancer (TNBC). Here, our integrated The Cancer Genome Atlas (TCGA) data set, tissue microarray-based analyses and multiple biologic evaluations together demonstrate a new small-molecule activator of ULK1 for better understanding of how ULK1, the mammalian homolog of yeast Atg1, as a potential drug target can regulate ACD by the ULK complex (ULK1-ATG13-RB1CC1/FIP200-ATG101), as well as other possible ULK1 interactors, including ATF3, RAD21 and CASP3/caspase3 in TNBC. Moreover, such new inspiring findings may help us discover that this activator of ULK1 (LYN-1604) with its anti-tumor activity and ACD-modulating mechanisms can be further exploited as a small-molecule candidate drug for future TNBC therapy.

Identification of factors required for m6 A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI.

PubMed

Růžička, Kamil; Zhang, Mi; Campilho, Ana; Bodi, Zsuzsanna; Kashif, Muhammad; Saleh, Mária; Eeckhout, Dominique; El-Showk, Sedeer; Li, Hongying; Zhong, Silin; De Jaeger, Geert; Mongan, Nigel P; Hejátko, Jan; Helariutta, Ykä; Fray, Rupert G

2017-07-01

N6-adenosine methylation (m 6 A) of mRNA is an essential process in most eukaryotes, but its role and the status of factors accompanying this modification are still poorly understood. Using combined methods of genetics, proteomics and RNA biochemistry, we identified a core set of mRNA m 6 A writer proteins in Arabidopsis thaliana. The components required for m 6 A in Arabidopsis included MTA, MTB, FIP37, VIRILIZER and the E3 ubiquitin ligase HAKAI. Downregulation of these proteins led to reduced relative m 6 A levels and shared pleiotropic phenotypes, which included aberrant vascular formation in the root, indicating that correct m 6 A methylation plays a role in developmental decisions during pattern formation. The conservation of these proteins amongst eukaryotes and the demonstration of a role in writing m 6 A for the E3 ubiquitin ligase HAKAI is likely to be of considerable relevance beyond the plant sciences. © 2017 The Authors. New Phytologist © 2017 New Phytologist Trust.

Plasma precipitation on Mercury's nightside and its implications for magnetospheric convection and exosphere generation.

NASA Astrophysics Data System (ADS)

Raines, J. M.; Slavin, J. A.; Tracy, P.; Gershman, D. J.; Zurbuchen, T.; Korth, H.; Anderson, B. J.; Solomon, S. C.

2015-12-01

Plasma impact onto Mercury's surface can be an important contributor to Mercury's exosphere through the process of ion sputtering. Under some circumstances, this process can produce a substantial fraction of the exosphere. When the impacting plasma originates from the magnetosphere itself, this sputtering process can conversely be considered as a sink for the plasma of the Mercury magnetosphere, providing evidence for the processes at work in that system. One such process is reconnection in Mercury's magnetotail, which can accelerate ions and electrons from the central plasma sheet toward the nightside of the planet. By analogy with processes at Earth, it is hypothesized that as these flows approach the planet, much of the plasma is diverted from impact onto the surface by the increasingly strong planetary magnetic field closer to the planet. The remainder of the plasma is expected to follow nearly dipolar field lines, impacting the nightside surface and potentially contributing to field-aligned currents. We present the first direct evidence that this process is operating at Mercury. We examine ion precipitation events on Mercury's nightside with the Fast Imaging Plasma Spectrometer (FIPS) on the MESSENGER spacecraft, which orbited Mercury from 2011 to 2015. We characterize the energy distributions of these events and their extent in latitude and local time. We use these observations to predict the precipitating proton flux from altitudes as low as 11 km. We use this information to bound the region of Mercury's surface that remains protected from plasma bombardment by the planetary dipole magnetic field, and to explore the implications of this information for magnetospheric convection and exosphere generation at Mercury.

Plasma precipitation on Mercury's nightside and its implications for magnetospheric convection and exosphere generation.

NASA Astrophysics Data System (ADS)

Raines, J. M.; Slavin, J. A.; Tracy, P.; Gershman, D. J.; Zurbuchen, T.; Dewey, R. M.; Sarantos, M.

2016-12-01

Plasma impact onto Mercury's surface can be an important contributor to Mercury's exosphere through the process of ion sputtering. Under some circumstances, this process can produce a substantial fraction of the exosphere. When the impacting plasma originates from the magnetosphere itself, this sputtering process can conversely be considered as a sink for the plasma of the Mercury magnetosphere, providing evidence for the processes at work in that system. One such process is reconnection in Mercury's magnetotail, which can accelerate ions and electrons from the central plasma sheet toward the nightside of the planet. By analogy with processes at Earth, it is hypothesized that as these flows approach the planet, much of the plasma is diverted from impact onto the surface by the increasingly strong planetary magnetic field closer to the planet. The remainder of the plasma is expected to follow nearly dipolar field lines, impacting the nightside surface and potentially contributing to field-aligned currents. We present the first direct evidence that this process is operating at Mercury. We examine ion precipitation events on Mercury's nightside with the Fast Imaging Plasma Spectrometer (FIPS) on the MESSENGER spacecraft, which orbited Mercury from 2011 to 2015. We characterize the energy distributions of these events and their extent in latitude and local time. We use these observations to predict the precipitating proton flux from altitudes as low as 11 km. We use this information to bound the region of Mercury's surface that remains protected from plasma bombardment by the planetary dipole magnetic field, and to explore the implications of this information for magnetospheric convection and exosphere generation at Mercury.

Fault Damage Zone Permeability in Crystalline Rocks from Combined Field and Laboratory Measurements

NASA Astrophysics Data System (ADS)

Mitchell, T.; Faulkner, D.

2008-12-01

In nature, permeability is enhanced in the damage zone of faults, where fracturing occurs on a wide range of scales. Here we analyze the contribution of microfracture damage on the permeability of faults that cut through low porosity, crystalline rocks by combining field and laboratory measurements. Microfracture densities surrounding strike-slip faults with well-constrained displacements ranging over 3 orders of magnitude (~0.12 m - 5000 m) have been analyzed. The faults studied are excellently exposed within the Atacama Fault Zone, where exhumation from 6-10 km has occurred. Microfractures in the form of fluid inclusion planes (FIPs) show a log-linear decrease in fracture density with perpendicular distance from the fault core. Damage zone widths defined by the density of FIPs scale with fault displacement, and an empirical relationship for microfracture density distribution throughout the damage zone with displacement is derived. Damage zone rocks will have experienced differential stresses that were less than, but some proportion of, the failure stress. As such, permeability data from progressively loaded, initially intact laboratory samples, in the pre-failure region provide useful insights into fluid flow properties of various parts of the damage zone. The permeability evolution of initially intact crystalline rocks under increasing differential load leading to macroscopic failure was determined at water pore pressures of 50 MPa and effective pressure of 10 MPa. Permeability is seen to increase by up to, and over, two orders of magnitude prior to macroscopic failure. Further experiments were stopped at various points in the loading history in order to correlate microfracture density within the samples with permeability. By combining empirical relationships determined from both quantitative fieldwork and experiments we present a model that allows microfracture permeability distribution throughout the damage zone to be determined as function of increasing fault displacement.

Characterization of an immunomodulatory Der p 2-FIP-fve fusion protein produced in transformed rice suspension cell culture.

PubMed

Su, Chin-Fen; Kuo, I-Chun; Chen, Peng-Wen; Huang, Chiung-Hui; Seow, See Voon; Chua, Kaw Yan; Yu, Su-May

2012-02-01

Der p 2, a major allergen of Dermatophagoides pteronyssinus mites, is one of the most clinically relevant allergens to allergic patients worldwide. FIP-fve protein (Fve) from the golden needle mushroom (Flammulina velutipes) is an immunomodulatory protein with potential Th1-skewed adjuvant properties. Here, we produced and immunologically evaluated a Der p 2-Fve fusion protein as a potential immunotherapeutic for allergic diseases. Using an inducible expression system in cultured rice suspension cells, the recombinant Der p 2-Fve fusion protein (designated as OsDp2Fve) was expressed in rice cells under the control of an α-amylase gene (αAmy8) promoter and secreted under sucrose starvation. OsDp2Fve was partially purified from the cultured medium. The conformation of Der p 2 in OsDp2Fve remains intact as reflected by its unaltered allergenicity, as assessed by human IgE ELISA and histamine release assays, compared to non-fusion Der p 2 protein. Furthermore, the Fve protein expressed in OsDp2Fve retains its in vitro lymphoproliferative activity but loses its hemagglutination and lymphoagglutination effects compared to the native protein. Notably, in vivo evaluation showed that mice administered with OsDp2Fve possessed an enhanced production of Der p 2-specific IgG antibodies without potentiating the production of Der p 2-specific IgE and Th2 effector cytokines in comparison with mice co-administered with native Fve and Der p 2 proteins. These results suggest that the recombinant Der p 2-Fve fusion protein produced in rice suspension cell cultures has a great potential for allergy immunotherapy.

Report of Official Foreign Travel to France May 8-27, 1998

DOE Office of Scientific and Technical Information (OSTI.GOV)

mason, j d

1998-06-11

The Department of Energy (DOE) has moved ever more rapidly towards electronic production, management, and dissemination of scientific and technical information. The World-Wide Web (WWW) has become a primary means of information dissemination. Electronic commerce (EC) is becoming the preferred means of procurement. DOE, like other government agencies, depends on and encourages the use of international standards in data communications. Among the most widely adopted standards is the Standard Generalized Markup Language (SGML, ISO 8879:1986, FIPS 152), which DOE has selected as the basis of its electronic management of documents. Besides the official commitment, which has resulted in several specializedmore » projects, DOE makes heavy use of coding derived from SGML, and its use is likely to increase in the future. Most documents on the WWW are coded in HTML (Hypertext Markup Language), which is an application of SGML. The World-Wide Web Consortium (W3C), with the backing of major software houses like Microsoft, Adobe, and Netscape, is promoting XML (eXtensible Markup Language), a class of SGML applications, for the future of the WWW and the basis for EC. In support of DOE's use of these standards, I have served since 1985 as Convenor of the international committee responsible for SGML and related standards, ISO/IEC JTC1/WG4 (WG4). During this trip I convened the spring 1998 meeting of WG4 in Paris, France. I also attended a major conference on the use of SGML and XML. At the close of the conference, I chaired a workshop of standards developers looking at ways of improving online searching of electronic documents. Note: Since the end of the meetings in France, JTC1 has raised the level of WG4 to a full Subcommittee; its designator is now ISO/IEC JTC1/SC34. WG4 maintains and continues to enhance several standards. In addition to SGML, which is the basis of HTML and XML, WG4 also works on the Document Style Semantics and Specification Language (DSSSL), which is the basis for the W3C's XSL (eXtensible Style Language, to be used with XML) and the Hypermedia/Time-based Document Structuring Language (HyTime), which is a major influence on the W3C's XLink (XML Linking Language). WG4 is also involved in work with the ISO's TC184, Industrial Data, on the linking of STEP (the standard for the interchange of product model data) with SGML. In addition to the widespread use of the WWW among DOE's plants and facilities in Oak Ridge and among DOE sites across the nation, there are several SGML-based projects at the Y-12 Plant. My project team in Information Technology Services has developed an SGML-based publications system that has been used for several major reports at the Y-12 Plant and Oak Ridge National Laboratory (ORNL). SGML is a component of the Weapons Records Archiving and Preservation (WRAP) project at Y-12 and is the format for catalog metadata chosen for weapons records by the Nuclear Weapons Information Group (NWIG). Supporting standards development allows DOE and Y-12 both input into the process and the opportunity to benefit from contact with some of the leading experts in the subject matter. Oak Ridge has been for some years the location to which other DOE sites turn for expertise in SGML and related topics.« less

In Pursuit of the FIP Effect in Stellar Coronae

NASA Technical Reports Server (NTRS)

Drake, Jeremy J.

2000-01-01

Observational data have been reduced. Sig Gem data have been fitted using the XSPEC software, though the treatment within this software of the Fe transitions arising from the n=2 levels is thought to be sufficiently inaccurate as to affect the results obtained. Data for the same star obtained by EUVE have been extracted from the archive and are being analyzed in order to try and constrain the coronal DEM. Results of the first sets of model fitting have been presented at an AAS meeting; a more substantial presentation of these and updated results in a main-stream referred journal is in progress.

Sequence of pNL194, a 79.3-Kilobase IncN Plasmid Carrying the blaVIM-1 Metallo-β-Lactamase Gene in Klebsiella pneumoniae▿

PubMed Central

Miriagou, V.; Papagiannitsis, C. C.; Kotsakis, S. D.; Loli, A.; Tzelepi, E.; Legakis, N. J.; Tzouvelekis, L. S.

2010-01-01

The nucleotide sequence of pNL194, a VIM-1-encoding plasmid, is described in this study. pNL194 (79,307 bp) comprised an IncN-characteristic segment (38,940 bp) and a mosaic structure (40,367 bp) including blaVIM-1, aacA7, aadA1, aadA2, dfrA1, dfrA12, aphA1, strA, strB, and sul1. Tn1000 or Tn5501 insertion within fipA probably facilitated recruitment of additional mobile elements carrying resistance genes. PMID:20660690

3D time-lapse analysis of Rab11/FIP5 complex: spatiotemporal dynamics during apical lumen formation.

PubMed

Mangan, Anthony; Prekeris, Rytis

2015-01-01

Fluorescent imaging of fixed cells grown in two-dimensional (2D) cultures is one of the most widely used techniques for observing protein localization and distribution within cells. Although this technique can also be applied to polarized epithelial cells that form three-dimensional (3D) cysts when grown in a Matrigel matrix suspension, there are still significant limitations in imaging cells fixed at a particular point in time. Here, we describe the use of 3D time-lapse imaging of live cells to observe the dynamics of apical membrane initiation site (AMIS) formation and lumen expansion in polarized epithelial cells.

Abundances, Ionization States, Temperatures, and FIP in Solar Energetic Particles

NASA Astrophysics Data System (ADS)

Reames, Donald V.

2018-04-01

The relative abundances of chemical elements and isotopes have been our most effective tool in identifying and understanding the physical processes that control populations of energetic particles. The early surprise in solar energetic particles (SEPs) was 1000-fold enhancements in {}3He/{}4He from resonant wave-particle interactions in the small "impulsive" SEP events that emit electron beams that produce type III radio bursts. Further studies found enhancements in Fe/O, then extreme enhancements in element abundances that increase with mass-to-charge ratio A/Q, rising by a factor of 1000 from He to Au or Pb arising in magnetic reconnection regions on open field lines in solar jets. In contrast, in the largest SEP events, the "gradual" events, acceleration occurs at shock waves driven out from the Sun by fast, wide coronal mass ejections (CMEs). Averaging many events provides a measure of solar coronal abundances, but A/Q-dependent scattering during transport causes variations with time; thus if Fe scatters less than O, Fe/O is enhanced early and depleted later. To complicate matters, shock waves often reaccelerate impulsive suprathermal ions left over or trapped above active regions that have spawned many impulsive events. Direct measurements of ionization states Q show coronal temperatures of 1-2 MK for most gradual events, but impulsive events often show stripping by matter traversal after acceleration. Direct measurements of Q are difficult and often unavailable. Since both impulsive and gradual SEP events have abundance enhancements that vary as powers of A/Q, we can use abundances to deduce the probable Q-values and the source plasma temperatures during acceleration, ≈3 MK for impulsive SEPs. This new technique also allows multiple spacecraft to measure temperature variations across the face of a shock wave, measurements otherwise unavailable and provides a new understanding of abundance variations in the element He. Comparing coronal abundances from SEPs and from the slow solar wind as a function of the first ionization potential (FIP) of the elements, remaining differences are for the elements C, P, and S. The theory of the fractionation of ions by Alfvén waves shows that C, P, and S are suppressed because of wave resonances during chromospheric transport on closed magnetic loops but not on open magnetic fields that supply the solar wind. Shock waves can accelerate ions from closed coronal loops that easily escape as SEPs, while the solar wind must emerge on open fields.

Emerging viruses in the Felidae: shifting paradigms.

PubMed

O'Brien, Stephen J; Troyer, Jennifer L; Brown, Meredith A; Johnson, Warren E; Antunes, Agostinho; Roelke, Melody E; Pecon-Slattery, Jill

2012-02-01

The domestic cat is afflicted with multiple viruses that serve as powerful models for human disease including cancers, SARS and HIV/AIDS. Cat viruses that cause these diseases have been studied for decades revealing detailed insight concerning transmission, virulence, origins and pathogenesis. Here we review recent genetic advances that have questioned traditional wisdom regarding the origins of virulent Feline infectious peritonitis (FIP) diseases, the pathogenic potential of Feline Immunodeficiency Virus (FIV) in wild non-domestic Felidae species, and the restriction of Feline Leukemia Virus (FeLV) mediated immune impairment to domestic cats rather than other Felidae species. The most recent interpretations indicate important new evolutionary conclusions implicating these deadly infectious agents in domestic and non-domestic felids.

[Community pharmacy and general internal medicine are at the same crossroads: some opportunities should be seized].

PubMed

Bugnon, O; Buchmann, M

2012-11-28

The medicines give some symptoms relief and save lives every day. However, the responsible use of medicines is not definitively attained for the modern health systems. The shortcomings in this area are the cause of major negative clinical outcomes for the patients and the cause of additional cost for the health financing system. The two centenarians, as the International Pharmaceutical Federation (FIP) and the "Policlinique Médicale Universitaire (PMU)" in Lausanne, preview the solutions from now on for reversing this trend, such as the interdisciplinary collaborative approaches, the introduction of adequate financial incentives and the strengthening of education and research in community medicine, pharmacy and health.

Emerging Viruses in the Felidae: Shifting Paradigms

PubMed Central

O’Brien, Stephen J.; Troyer, Jennifer L.; Brown, Meredith A.; Johnson, Warren E.; Antunes, Agostinho; Roelke, Melody E.; Pecon-Slattery, Jill

2012-01-01

The domestic cat is afflicted with multiple viruses that serve as powerful models for human disease including cancers, SARS and HIV/AIDS. Cat viruses that cause these diseases have been studied for decades revealing detailed insight concerning transmission, virulence, origins and pathogenesis. Here we review recent genetic advances that have questioned traditional wisdom regarding the origins of virulent Feline infectious peritonitis (FIP) diseases, the pathogenic potential of Feline Immunodeficiency Virus (FIV) in wild non-domestic Felidae species, and the restriction of Feline Leukemia Virus (FeLV) mediated immune impairment to domestic cats rather than other Felidae species. The most recent interpretations indicate important new evolutionary conclusions implicating these deadly infectious agents in domestic and non-domestic felids. PMID:22470834

Overview of TRMM Data Products and Services

NASA Technical Reports Server (NTRS)

Stocker, Erich Franz; Aman, A.; Bman, B.; Cman, C.

2007-01-01

November 27, 2007 marks the l0th anniversary of the launch of the Tropical Rainfall Measuring Mission (TRMM) satellite. In anticipation of this anniversary, this paper will present an overview of the various TRMM data products currently available including the standard products, near real-time products, special products, and prototype products. It also will present an easy way to obtain these data. TRMM standard products have been publicly available since a few months after launch in November 1997. TRMM is currently on version 6 of the data product. Version 3 was the "at launch" version. The approval for each of these versions came through the Joint TRMM Science Team. Standard products are divided into 3 categories: single TRMM instrument, Visible Infrared Scanner (VIRS), TRMM Microwave Imager (TMI), and Precipitation Radar (PR); combined TRMM products (PR and TMI); finally TRMM and other satellites (combined, TMI, SSMI, AMSRE, AMSU). The single TRMM instrument products are processed through 4 levels: Level lA, science data packets processed into orbital files; Level 1B and lC, geolocated data at the instrument field of view; Level 2, geolocated, geophysical parameters at the instrument field of view; Level 3, time aggregated, gridded geophysical parameters. These products are available with 24 hours of production through an anonymous ftp account on trmmopen.gsfc.nasa.gov. The TRMM data system started to produce near real-time products at the end of 1999. They are currently available only through a controlled user account. However, approval to get access to this account can be obtained by sending a note to Erich.F.Stoclter@nasa.gov providing the reason for access and contact information including a valid email. TRMM is not restricting access but needs the information to determine the usefulness of near-real time data to the general science community including applications agencies. TRMM near real-time products are swath products up to Level 2 of processing. The oldest data in the swath is generally no older than 120 minutes when it becomes available to the community. The real-time products including a VIRS level lB, a TMI parameter reduced 1B, a TMI level 2 parameter reduced rain product, a PR level 2 surface rain product, and a PR level 2 rain product with 25 vertical levels. Currently, TRMM also produces a gridded 3 hour global merged product from several radiometers including AMSU and from radiometercalibrated IR data. The paper also describes several simple-format gridded text products available fiom the trmmopen.gsfc.nasa.gov anonymous fip server denoted as 3668 products. These products were produced to provide rain estimates from the three TRMM instruments in a universal format (ASCII) that requires very little data format knowledge. The paper goes on to describe prototype L1 radiometer products that apply an early intercalibration approach that provides a starting point to be used for Global Precipitation Measurement mission radiometer products. The paper also provides a brief overview of a precipitation features data product being produced using TRMM products including the Lighting Imaging Sensor (LIS) using an algorithm developed at the University of Utah and distributed by that organization. The paper concludes with some possible changes to products that are planned for the next reprocessing cycle and special services such as geographical subsetting available to the science community.

A functional interplay between the small GTPase Rab11a and mitochondria-shaping proteins regulates mitochondrial positioning and polarization of the actin cytoskeleton downstream of Src family kinases.

PubMed

Landry, Marie-Claude; Champagne, Claudia; Boulanger, Marie-Chloé; Jetté, Alexandra; Fuchs, Margit; Dziengelewski, Claire; Lavoie, Josée N

2014-01-24

It is believed that mitochondrial dynamics is coordinated with endosomal traffic rates during cytoskeletal remodeling, but the mechanisms involved are largely unknown. The adenovirus early region 4 ORF4 protein (E4orf4) subverts signaling by Src family kinases (SFK) to perturb cellular morphology, membrane traffic, and organellar dynamics and to trigger cell death. Using E4orf4 as a model, we uncovered a functional connection between mitochondria-shaping proteins and the small GTPase Rab11a, a key regulator of polarized transport via recycling endosomes. We found that E4orf4 induced dramatic changes in the morphology of mitochondria along with their mobilization at the vicinity of a polarized actin network typifying E4orf4 action, in a manner controlled by SFK and Rab11a. Mitochondrial remodeling was associated with increased proximity between Rab11a and mitochondrial membranes, changes in fusion-fission dynamics, and mitochondrial relocalization of the fission factor dynamin-related protein 1 (Drp1), which was regulated by the Rab11a effector protein FIP1/RCP. Knockdown of FIP1/RCP or inhibition of Drp1 markedly impaired mitochondrial remodeling and actin assembly, involving Rab11a-mediated mitochondrial dynamics in E4orf4-induced signaling. A similar mobilization of mitochondria near actin-rich structures was mediated by Rab11 and Drp1 in viral Src-transformed cells and contributed to the biogenesis of podosome rosettes. These findings suggest a role for Rab11a in the trafficking of Drp1 to mitochondria upon SFK activation and unravel a novel functional interplay between Rab11a and mitochondria during reshaping of the cell cytoskeleton, which would facilitate mitochondria redistribution near energy-requiring actin-rich structures.

Nutrient-regulated Phosphorylation of ATG13 Inhibits Starvation-induced Autophagy*

PubMed Central

Puente, Cindy; Hendrickson, Ronald C.; Jiang, Xuejun

2016-01-01

Autophagy is a conserved catabolic process that utilizes a defined series of membrane trafficking events to generate a de novo double-membrane vesicle termed the autophagosome, which matures by fusing to the lysosome. Subsequently, the lysosome facilitates the degradation and recycling of the cytoplasmic cargo. In yeast, the upstream signals that regulate the induction of starvation-induced autophagy are clearly defined. The nutrient-sensing kinase Tor inhibits the activation of autophagy by regulating the formation of the Atg1-Atg13-Atg17 complex, through hyperphosphorylation of Atg13. However, in mammals, the ortholog complex ULK1-ATG13-FIP200 is constitutively formed. As such, the molecular mechanism by which mTOR regulates mammalian autophagy is unknown. Here we report the identification and characterization of novel nutrient-regulated phosphorylation sites on ATG13: Ser-224 and Ser-258. mTOR directly phosphorylates ATG13 on Ser-258 while Ser-224 is modulated by the AMPK pathway. In ATG13 knock-out cells reconstituted with an unphosphorylatable mutant of ATG13, ULK1 kinase activity is more potent, and amino acid starvation induced more rapid ATG13 and ULK1 translocation. These events culminated in a more rapid starvation-induced autophagy response. Therefore, ATG13 phosphorylation plays a crucial role in autophagy regulation. PMID:26801615

Adapting diagrams from physics textbooks: improving the autonomy of blind students

NASA Astrophysics Data System (ADS)

Dickman, Adriana; Martins, Alexandre; Ferreira, Amauri

2014-03-01

In this work we elaborate and test a glossary consisting of a set of objects and their symbols. The symbols are designed to represent objects frequently used in mechanics diagrams, such as vectors, ropes, pulleys, blocks and surfaces, and can be used to adapt drawings of physics situations in textbooks for blind high school students. The educational product was tested at a specialized school for the blind. The results indicate that adequate training can help blind students to become familiar with the symbols, and to identify them in a problem without the need of a description. This educational product can help blind students to achieve the same conditions of autonomy as sighted ones, when studying physics. Research supported by CNPq, Capes, Fapemig and FIP/PUC-MG (Brazil).

Electrical generating unit inventory 1976-1986: Illinois, Indiana, Kentucky, Ohio, Pennsylvania and West Virginia

NASA Astrophysics Data System (ADS)

Jansen, S. D.

1981-09-01

The ORBES region consists of all of Kentucky, most of West Virginia, substantial parts of Illinois, Indiana, and Ohio, and southwestern Pennsylvania. The inventory lists installed electrical generating capacity in commercial service as of December 1, 1976, and scheduled capacity additions and removals between 1977 and 1986 in the six ORBES states (Illinois, Indiana, Kentucky, Ohio, Pennsylvania, and West Virginia). The following information is included for each electrical generating unit: unit ID code, company index, whether point or industrial ownership, plant name, whether inside or outside the ORBES region, FIPS county code, type of unit, size in megawatts, type of megawatt rating, status of unit, data of commercial operation, scheduled retirement date, primary fuel, alternate fuel, type of cooling, source of cooling water, and source of information.

Feline and canine coronaviruses: common genetic and pathobiological features.

PubMed

Le Poder, Sophie

2011-01-01

A new human coronavirus responsible for severe acute respiratory syndrome (SARS) was identified in 2003, which raised concern about coronaviruses as agents of serious infectious disease. Nevertheless, coronaviruses have been known for about 50 years to be major agents of respiratory, enteric, or systemic infections of domestic and companion animals. Feline and canine coronaviruses are widespread among dog and cat populations, sometimes leading to the fatal diseases known as feline infectious peritonitis (FIP) and pantropic canine coronavirus infection in cats and dogs, respectively. In this paper, different aspects of the genetics, host cell tropism, and pathogenesis of the feline and canine coronaviruses (FCoV and CCoV) will be discussed, with a view to illustrating how study of FCoVs and CCoVs can improve our general understanding of the pathobiology of coronaviruses.

Design, synthesis, and biological evaluation of novel iso-D-2',3'-dideoxy-3'-fluorothianucleoside derivatives.

PubMed

Kim, Kyung Ran; Moon, Hyung Ryong; Park, Ah-Young; Chun, Moon Woo; Jeong, Lak Shin

2007-01-01

Novel iso-d-2',3'-dideoxythianucleoside derivatives 1-4 were designed and asymmetrically synthesized as a bioisostere of lamivudine to search for new anti-HIV agents. The information about using sulfur participation occurred on DAST fluorination and Mitsunobu reaction will be of great help in synthesizing sulfur-containing compounds. Final compounds 1-4 were evaluated against HIV-1 and 2, HSV-1 and 2, EMCV, Cox. B3, VSV, FluA (Taiwan), FluA (Johan.), FCV, and FIP. Only cytosine analogue 3 showed a potent anti-VSV activity (EC(50)=9.43microg/mL). This result implies that iso-2',3'-dideoxy sugar templates might play a role of a sugar surrogate of nucleosides for the development of anti-RNA virus agent.

A Survey of Pharmacy Education in Thailand.

PubMed

Chanakit, Teeraporn; Low, Bee Yean; Wongpoowarak, Payom; Moolasarn, Summana; Anderson, Claire

2014-11-15

To explore the current status of pharmacy education in Thailand. The International Pharmaceutical Federation of the World Health Organization's (FIP-WHO) Global Survey of Pharmacy Schools was used for this study. The survey instrument was distributed to the deans of the 19 faculties (colleges) of pharmacy in Thailand. More than half the colleges have been in existence less than 20 years, and the government owns 80% of them. There were 2 paths of admission to study pharmacy: direct admission and central admission system. The doctor of pharmacy (PharmD) programs can be divided into 4 types. Approximately 60% of all teaching staff holds a doctoral degree. Regarding the work balance among teaching staff, around 60% focus on teaching activities, 20% focus on research, and less than 20% focus on patient care services concurrent with real practice teaching. The proportion of student time dedicated to theory, practice, and research in PharmD programs is 51.5%, 46.7%, and 1.8%, respectively. Sites owned by the colleges or by others were used for student training. Colleges followed the Office of the National Education Standards' Internal Quality Assurance (IQA) and External Quality Assurance (EQA), and the Pharmacy Council's Quality Assessment (ONESQA). This study provides a picture of the current status of curriculum, teaching staff, and students in pharmacy education in Thailand. The curriculum was adapted from the US PharmD program with the aim of meeting the country's needs and includes industrial pharmacy and public health tracks as well as clinical tracks. However, this transition in pharmacy education in Thailand needs to be monitored and evaluated.

Fault Damage Zone Permeability in Crystalline Rocks from Combined Field and Laboratory Measurements: Can we Predict Damage Zone Permeability?

NASA Astrophysics Data System (ADS)

Mitchell, T. M.; Faulkner, D. R.

2009-04-01

Models predicting crustal fluid flow are important for a variety of reasons; for example earthquake models invoking fluid triggering, predicting crustal strength modelling flow surrounding deep waste repositories or the recovery of natural resources. Crustal fluid flow is controlled by both the bulk transport properties of rocks as well as heterogeneities such as faults. In nature, permeability is enhanced in the damage zone of faults, where fracturing occurs on a wide range of scales. Here we analyze the contribution of microfracture damage on the permeability of faults that cut through low porosity, crystalline rocks by combining field and laboratory measurements. Microfracture densities surrounding strike-slip faults with well-constrained displacements ranging over 3 orders of magnitude (~0.12 m - 5000 m) have been analyzed. The faults studied are excellently exposed within the Atacama Fault Zone, where exhumation from 6-10 km has occurred. Microfractures in the form of fluid inclusion planes (FIPs) show a log-linear decrease in fracture density with perpendicular distance from the fault core. Damage zone widths defined by the density of FIPs scale with fault displacement, and an empirical relationship for microfracture density distribution throughout the damage zone with displacement is derived. Damage zone rocks will have experienced differential stresses that were less than, but some proportion of, the failure stress. As such, permeability data from progressively loaded, initially intact laboratory samples, in the pre-failure region provide useful insights into fluid flow properties of various parts of the damage zone. The permeability evolution of initially intact crystalline rocks under increasing differential load leading to macroscopic failure was determined at water pore pressures of 50 MPa and effective pressure of 10 MPa. Permeability is seen to increase by up to, and over, two orders of magnitude prior to macroscopic failure. Further experiments were stopped at various points in the loading history in order to correlate microfracture density within the samples with permeability. By combining empirical relationships determined from both quantitative fieldwork and experiments we present a new model that allows microfracture permeability distribution throughout the damage zone to be determined as function of increasing fault displacement.

The development and testing of the fast imaging plasma spectrometer and its application in the plasma environment at Mercury

NASA Astrophysics Data System (ADS)

Koehn, Patrick Leo

The plasma environment at Mercury is a rich laboratory for studying the interaction of the solar wind with a planet. Three primary populations of ions exist at Mercury: solar wind, magnetospheric particles, and pickup ions. Pickup ions are generated through the ionization of Mercury's exosphere or are sputtered particles from the Mercury surface. A comprehensive mission to Mercury should include a sensor that is able to determine the dynamical properties and composition of all three plasma components. The Fast Imaging Plasma Spectrometer (FIPS) is an instrument to measure the composition of these ion populations and their three-dimensional velocity distribution functions. It is lightweight, fast, and has a very large field of view, and these properties made possible its accommodation within the highly mass- constrained payload of MESSENGER (MErcury: Surface, Space ENvironment, GEochemistry, Ranging) mission, a Mercury orbiter. This work details the development cycle of FIPS, from concept to prototype testing. It begins with science studies of the magnetospheric and pickup ion environments of Mercury, using state-of-the-art computer simulations to produce static and quasi-dynamic magnetospheric systems. Predictions are made of the spatially variable plasma environment at Mercury, and the temporally varying magnetosphere-solar wind interaction is examined. Pickup ion studies provide insights to particle loss mechanisms and the nature of the radar-bright regions at the Hermean poles. These studies produce science requirements for successfully measuring this environment with an orbiting mass spectrometer. With these science requirements in mind, a concept for a new electrostatic analyzer is created. This concept is considered from a theoretical standpoint, and compared with other, similarly performing instruments, both of the past and currently in use. The development cycle continues with instrument simulation, which allows the design to be adjusted to fit within the science requirements of the mission. Finally, a prototype electrostatic is constructed and tested in a space- simulating vacuum chamber system. The results of these tests are compared with the simulation results, and ultimately shown to fit within the science requirements for the MESSENGER mission.

Infection of cats with atypical feline coronaviruses harbouring a truncated form of the canine type I non-structural ORF3 gene.

PubMed

Le Poder, Sophie; Pham-Hung d'Alexandry d'Orangiani, Anne-Laure; Duarte, Lidia; Fournier, Annie; Horhogea, Cristina; Pinhas, Carine; Vabret, Astrid; Eloit, Marc

2013-12-01

Feline and canine coronaviruses (FCoV and CCoV, respectively) are common pathogens of cats and dogs sometimes leading to lethal infections named feline infectious peritonitis (FIP) and canine pantropic coronavirus infection. FCoV and CCoV are each subdivided into two serotypes, FCoV-I/II and CCoV-I/II. A phylogenetic relationship is evident between, on one hand, CCoV-I/FCoV-I, and on the other hand, CCoV-II/FCoV-II, suggesting that interspecies transmission can occur. The aim of the present study was to evaluate the prevalence of coronavirus (CoV)-infected cats according to their contact with dogs and to genetically analyse the CoV strains infecting cats. From 2003 to 2009, we collected 88 faecal samples from healthy cats and 11 ascitic fluids from FIP cats. We investigated the possible contact with dog in the household and collected dogs samples if appropriate. Out of 99 cat samples, 26 were coronavirus positive, with six cats living with at least one dog, thus showing that contact with dogs does not appear as a predisposing factor for cats CoV infections. Molecular and phylogenetic analyses of FCoV strains were conducted using partial N and S sequences. Six divergent strains were identified with the N gene clustering with CCoV-I whereas the 3' end of S was related to FCoV-I. Further analysis on those six samples was attempted by researching the presence of the ORF3 gene, the latter being peculiar to CCoV-I to date. We succeeded to amplify the ORF3 gene in five samples out of six. Thus, our data strongly suggest the circulation of atypical FCoV strains harbouring the CCoV-I ORF3 gene among cats. Moreover, the ORF3 genes recovered from the feline strains exhibited shared deletions, never described before, suggesting that these deletions could be critical in the adaptation of these strains to the feline host. Copyright © 2013 The Authors. Published by Elsevier B.V. All rights reserved.

Proceedings of the NASTRAN (Tradename) Users’ Colloquium (11th) Held in San Francisco, California on 2-6 May 1983

DTIC Science & Technology

1982-11-01

1430 2, 1, 0 1876 1988 1952 0, 1, 1 1953 1963 1928 1, 1, 1 2074 2089 2048 2, 1, 1 2401 2499 2440 3, 1, 0 2442 2875 2808 3, 1, 1 2866 3346 3233 f, n...PPFrPIDF/NOSET $ VEC USETD:/VP/*P*/*COMP*/*R* $ VEC USETI/Vt’/*D:*/*CDMP*/*R* $ PARTN PPF ,v VP/PPF1 ,PPF2yy,/ 1 $ PARTN PtIFv , VDi /P’I:FIP’F2, /I...PARTN MI)DtiVI:’, MDtti ,ML’D21 ,Mt’D1;2,MtiE122 $ PARTN BIIE’vVt’,/BLID). ,BiliD21 ,BDIl 2 BDE󈧚 $ PARTN KDlL’ VDI ,/KI:II vKDEI2i ,K~Ith2, KEIE󈧚

A Shared Focus: Comparing the Australian, Canadian, United Kingdom and United States Pharmacy Learning Outcome Frameworks and the Global Competency Framework.

PubMed

Stupans, Ieva; Atkinson, Jeffrey; Meštrović, Arijana; Nash, Rose; Rouse, Michael J

2016-09-10

This paper presents an analysis of the end of degree expectations, expressed as learning outcomes, for pharmacy graduates from Australia, Canada, United Kingdom and United States. The authors compare the end of degree expectations, through mapping these requirements to the International Pharmaceutical Federation (FIP) Global Competency Framework (GbCF). The anticipated end of degree expectations are similar but also reveal some individual characteristics. Irrespective of degree title, achievement of learning outcomes specified in any one of the four jurisdictions should enable students to become pharmacists who are patient-orientated medicines experts. The mapping provides impetus for cross-border institutional networking to generate a dependable set of assessment tools across national borders developing a common metric for outcome assessment irrespective of different program delivery.

CCPG1, a cargo receptor required for reticulophagy and endoplasmic reticulum proteostasis.

PubMed

Smith, Matthew D; Wilkinson, Simon

2018-06-19

The importance of selective macroautophagy/autophagy in cellular health is increasingly evident. The selective degradation of portions of the endoplasmic reticulum (ER), or reticulophagy, is an emerging example but requires further mechanistic detail and broad evidence of physiological relevance. In a recent study, we identified CCPG1, an ER-resident transmembrane protein that can bind to Atg8-family proteins and, independently and discretely, to RB1CC1/FIP200. Both of these interactions are required to facilitate CCPG1's function as a reticulophagy cargo receptor. CCPG1 transcripts are inducible by ER stress, providing a direct link between ER stress and reticulophagy. In vivo, CCPG1 prevents the hyper-accumulation of insoluble protein within the ER lumen of pancreatic acinar cells and alleviates ER stress. Accordingly, CCPG1 loss sensitizes the exocrine pancreas to tissue injury.