Equilibrium Line Altitude fluctuations at HualcaHualca volcano (southern Peru).

NASA Astrophysics Data System (ADS)

Alcalá, Jesus; Palacios, David; Juan Zamorano, Jose

2015-04-01

Interest in Andean glaciers has substantially increased during the last decades, due to its high sensitivity to climate fluctuations. In this sense, Equilibrium Line Altitude (ELA) is a reliable indicator of climate variability that has been frequently used to reconstruct palaeoenvironmental conditions at different temporal and spatial scales. However, the number of sites with ELA reconstructions is still insufficient to determine patterns in tropical climate or estimations of atmospheric cooling since the Last Glacial Maximum. The main purpose of this study is to contribute in resolving tropical climate evolution through ELA calculations on HualcaHualca (15° 43' S; 71° 52' W; 6,025 masl), a large andesitic stratovolcano located in the south-western Peruvian Andes approximately 70 km north-west of Arequipa. We applied Terminus Headwall Altitude Ratio (THAR) with 0.2; 0.4; 0.5; 0.57 ratios, Accumulation Area Ratio (AAR) and Accumulation Area Balance Ratio (AABR) methods in four valleys of HualcaHualca volcano: Huayuray (north side), Pujro Huayjo (southwest side), Mollebaya (east side) and Mucurca (west side). To estimate ELA depression, we calculated the difference between the ELA on 1955 with its position in the Maximum Glacier Extent (MGE), Tardiglacial phases, little Ice Age (LIA) and 2000. Paleotemperature reconstructions derived from vertical temperature gradient 6.5° C / 1 km, based on GODDARD global observation system considered the most appropriate model for arid Andes. During MGE, the ELA was located between 5,005 (AABR) and 5,215 (AAR 0.67) masl. But in 1955, ELA rose to 5,685 (AABR) - 5,775 (AAR 0.67) masl. The ELA depression between those two phases is 560 - 680 m that implies a temperature decrease of 3.5° - 4.4° C. The experimental process based in the use and contrast of different ELA reconstruction techniques applied in this study suggests that THAR (0.57), AAR (0.67) or AABR are the most consistent procedures for HualcaHualca glaciers, while THAR with ratios 0.2; 0.4 and 0.5 tend to underestimate it's position. Research funded by Cryocrisis project (CGL2012-35858), Government of Spain.

Strategic avionics technology definition studies. Subtask 3-1A3: Electrical Actuation (ELA) Systems Test Facility

NASA Technical Reports Server (NTRS)

Rogers, J. P.; Cureton, K. L.; Olsen, J. R.

1994-01-01

Future aerospace vehicles will require use of the Electrical Actuator systems for flight control elements. This report presents a proposed ELA Test Facility for dynamic evaluation of high power linear Electrical Actuators with primary emphasis on Thrust Vector Control actuators. Details of the mechanical design, power and control systems, and data acquisition capability of the test facility are presented. A test procedure for evaluating the performance of the ELA Test Facility is also included.

Web-Based Mapping Puts the World at Your Fingertips

NASA Technical Reports Server (NTRS)

2008-01-01

NASA's award-winning Earth Resources Laboratory Applications Software (ELAS) package was developed at Stennis Space Center. Since 1978, ELAS has been used worldwide for processing satellite and airborne sensor imagery data of the Earth's surface into readable and usable information. DATASTAR Inc., of Picayune, Mississippi, has used ELAS software in the DATASTAR Image Processing Exploitation (DIPEx) desktop and Internet image processing, analysis, and manipulation software. The new DIPEx Version III includes significant upgrades and improvements compared to its esteemed predecessor. A true World Wide Web application, this product evolved with worldwide geospatial dimensionality and numerous other improvements that seamlessly support the World Wide Web version.

Elastase-2, an angiotensin II-generating enzyme, contributes to increased angiotensin II in resistance arteries of mice with myocardial infarction.

PubMed

Becari, Christiane; Silva, Marcondes A B; Durand, Marina T; Prado, Cibele M; Oliveira, Eduardo B; Ribeiro, Mauricio S; Salgado, Helio C; Salgado, Maria Cristina O; Tostes, Rita C

2017-05-01

Angiotensin II (Ang II), whose generation largely depends on angiotensin-converting enzyme (ACE) activity, mediates most of the renin-angiotensin-system (RAS) effects. Elastase-2 (ELA-2), a chymotrypsin-serine protease elastase family member 2A, alternatively generates Ang II in rat arteries. Myocardial infarction (MI) leads to intense RAS activation, but mechanisms involved in Ang II-generation in resistance arteries are unknown. We hypothesized that ELA-2 contributes to vascular Ang II generation and cardiac damage in mice subjected to MI. Concentration-effect curves to Ang I and Ang II were performed in mesenteric resistance arteries from male wild type (WT) and ELA-2 knockout (ELA-2KO) mice subjected to left anterior descending coronary artery ligation (MI). MI size was similar in WT and ELA-2KO mice. Ejection fraction and fractional shortening after MI similarly decreased in both strains. However, MI decreased stroke volume and cardiac output in WT, but not in ELA-2KO mice. Ang I-induced contractions increased in WT mice subjected to MI (MI-WT) compared with sham-WT mice. No differences were observed in Ang I reactivity between arteries from ELA-2KO and ELA-2KO subjected to MI (MI-ELA-2KO). Ang I contractions increased in arteries from MI-WT versus MI-ELA-2KO mice. Chymostatin attenuated Ang I-induced vascular contractions in WT mice, but did not affect Ang I responses in ELA-2KO arteries. These results provide the first evidence that ELA-2 contributes to increased Ang II formation in resistance arteries and modulates cardiac function after MI, implicating ELA-2 as a key player in ACE-independent dysregulation of the RAS. © 2017 The British Pharmacological Society.

Effect of excimer laser annealing on a-InGaZnO thin-film transistors passivated by solution-processed hybrid passivation layers

NASA Astrophysics Data System (ADS)

Bermundo, Juan Paolo; Ishikawa, Yasuaki; Fujii, Mami N.; Nonaka, Toshiaki; Ishihara, Ryoichi; Ikenoue, Hiroshi; Uraoka, Yukiharu

2016-01-01

We demonstrate the use of excimer laser annealing (ELA) as a low temperature annealing alternative to anneal amorphous InGaZnO (a-IGZO) thin-film transistors (TFTs) passivated by a solution-processed hybrid passivation layer. Usually, a-IGZO is annealed using thermal annealing at high temperatures of up to 400 °C. As an alternative to high temperature thermal annealing, two types of ELA, XeCl (308 nm) and KrF (248 nm) ELA, are introduced. Both ELA types enhanced the electrical characteristics of a-IGZO TFTs leading to a mobility improvement of ~13 cm2 V-1 s-1 and small threshold voltage which varied from ~0-3 V. Furthermore, two-dimensional heat simulation using COMSOL Multiphysics was used to identify possible degradation sites, analyse laser heat localization, and confirm that the substrate temperature is below 50 °C. The two-dimensional heat simulation showed that the substrate temperature remained at very low temperatures, less than 30 °C, during ELA. This implies that any flexible material can be used as the substrate. These results demonstrate the large potential of ELA as a low temperature annealing alternative for already-passivated a-IGZO TFTs.

Impacts of excimer laser annealing on Ge epilayer on Si

NASA Astrophysics Data System (ADS)

Huang, Zhiwei; Mao, Yichen; Yi, Xiaohui; Lin, Guangyang; Li, Cheng; Chen, Songyan; Huang, Wei; Wang, Jianyuan

2017-02-01

The impacts of excimer laser annealing on the crystallinity of Ge epilayers on Si substrate grown by low- and high-temperature two-step approach in an ultra-high vacuum chemical vapor deposition system were investigated. The samples were treated by excimer laser annealing (ELA) at various laser power densities with the temperature above the melting point of Ge, while below that of Si, resulting in effective reduction of point defects and dislocations in the Ge layer with smooth surface. The full-width at half-maximum (FWHM) of X-ray diffraction patterns of the low-temperature Ge epilayer decreases with the increase in laser power density, indicating the crystalline improvement and negligible effect of Ge-Si intermixing during ELA processes. The short laser pulse time and large cooling rate cause quick melting and recrystallization of Ge epilayer on Si in the non-thermal equilibrium process, rendering tensile strain in Ge epilayer as calculated quantitatively with thermal mismatch between Si and Ge. The FWHM of X-ray diffraction patterns is significantly reduced for the two-step grown samples after treated by a combination of ELA and conventional furnace thermal annealing, indicating that the crystalline of Ge epilayer is improved more effectively with pre- annealing by excimer laser.

Development of a 32-bit UNIX-based ELAS workstation

NASA Technical Reports Server (NTRS)

Spiering, Bruce A.; Pearson, Ronnie W.; Cheng, Thomas D.

1987-01-01

A mini/microcomputer UNIX-based image analysis workstation has been designed and is being implemented to use the Earth Resources Laboratory Applications Software (ELAS). The hardware system includes a MASSCOMP 5600 computer, which is a 32-bit UNIX-based system (compatible with AT&T System V and Berkeley 4.2 BSD operating system), a floating point accelerator, a 474-megabyte fixed disk, a tri-density magnetic tape drive, and an 1152 by 910 by 12-plane color graphics/image interface. The software conversion includes reconfiguring the ELAs driver Master Task, recompiling and then testing the converted application modules. This hardware and software configuration is a self-sufficient image analysis workstation which can be used as a stand-alone system, or networked with other compatible workstations.

Dysregulation of the cortisol diurnal rhythm following prenatal alcohol exposure and early life adversity.

PubMed

McLachlan, Kaitlyn; Rasmussen, Carmen; Oberlander, Tim F; Loock, Christine; Pei, Jacqueline; Andrew, Gail; Reynolds, James; Weinberg, Joanne

2016-06-01

The hypothalamic-pituitary-adrenal (HPA) axis is impacted by a multitude of pre- and postnatal factors. Developmental programming of HPA axis function by prenatal alcohol exposure (PAE) has been demonstrated in animal models and in human infants, but remains understudied in older children and adolescents. Moreover, early life adversity (ELA), which occurs at higher rates in children with PAE than in non-exposed children, may also play a role in programming the stress response system. In a cohort of children and adolescents with PAE and ELA (PAE + ELA), we evaluated HPA function through assessment of diurnal cortisol activity compared to that in typically developing controls, as well as the associations among specific ELAs, adverse outcomes, protective factors, and diurnal cortisol. Morning and evening saliva samples were taken under basal conditions from 42 children and adolescents (5-18 years) with PAE + ELA and 43 typically developing controls. High rates of ELA were shown among children with PAE, and significantly higher evening cortisol levels and a flatter diurnal slope were observed in children with PAE + ELA, compared to controls. Medication use in the PAE + ELA group was associated with lower morning cortisol levels, which were comparable to controls. Complex associations were found among diurnal cortisol patterns in the PAE + ELA group and a number of ELAs and later adverse outcomes, whereas protective factors were associated with more typical diurnal rhythms. These results complement findings from research on human infants and animal models showing dysregulated HPA function following PAE, lending weight to the suggestion that PAE and ELA may interact to sensitize the developing HPA axis. The presence of protective factors may buffer altered cortisol regulation, underscoring the importance of early assessment and interventions for children with FASD, and in particular, for the many children with FASD who also have ELA. Copyright © 2016 Elsevier Inc. All rights reserved.

Dysregulation of the cortisol diurnal rhythm following prenatal alcohol exposure and early life adversity

PubMed Central

McLachlan, Kaitlyn; Rasmussen, Carmen; Oberlander, Tim F.; Loock, Christine; Pei, Jacqueline; Andrew, Gail; Reynolds, James; Weinberg, Joanne

2016-01-01

The hypothalamic-pituitary-adrenal (HPA) axis is impacted by a multitude of pre- and postnatal factors. Developmental programming of HPA axis function by prenatal alcohol exposure (PAE) has been demonstrated in animal models and in human infants, but remains understudied in older children and adolescents. Moreover, early life adversity (ELA), which occurs at higher rates in children with PAE than in non-exposed children, may also play a role in programming the HPA or stress response system. In a cohort of children and adolescents with PAE and ELA (PAE + ELA), we evaluated HPA function through assessment of diurnal cortisol activity compared to that in typically developing controls, as well as the associations among specific ELAs, adverse outcomes, protective factors, and diurnal cortisol. Morning and evening saliva samples were taken under basal conditions from 42 children and adolescents (5–18 years) with PAE + ELA and 43 typically developing controls. High rates of ELA were shown among children with PAE, and significantly higher evening cortisol levels and a flatter diurnal slope were observed in children with PAE + ELA, compared to controls. Medication use in the PAE + ELA group was associated with lower morning cortisol levels, which were comparable to controls. Complex associations were found among diurnal cortisol patterns in the PAE + ELA group and a number of ELAs and later adverse outcomes, whereas protective factors were associated with more typical diurnal rhythms. These results complement findings from research on human infants and animal models showing dysregulated HPA function following PAE, lending weight to the suggestion that PAE and ELA may interact to sensitize the developing HPA axis. The presence of protective factors may buffer altered cortisol regulation, underscoring the importance of early assessment and interventions for children with FASD, and in particular, for the many children with FASD who also have ELA. PMID:27286932

T Cell Immunosenescence after Early Life Adversity: Association with Cytomegalovirus Infection.

PubMed

Elwenspoek, Martha M C; Sias, Krystel; Hengesch, Xenia; Schaan, Violetta K; Leenen, Fleur A D; Adams, Philipp; Mériaux, Sophie B; Schmitz, Stephanie; Bonnemberger, Fanny; Ewen, Anouk; Schächinger, Hartmut; Vögele, Claus; Muller, Claude P; Turner, Jonathan D

2017-01-01

Early life adversity (ELA) increases the risk for multiple age-related diseases, such as diabetes type 2 and cardiovascular disease. As prevalence is high, ELA poses a major and global public health problem. Immunosenescence, or aging of the immune system, has been proposed to underlie the association between ELA and long-term health consequences. However, it is unclear what drives ELA-associated immunosenescence and which cells are primarily affected. We investigated different biomarkers of immunosenescence in a healthy subset of the EpiPath cohort. Participants were either parent-reared (Ctrl, n  = 59) or had experienced separation from their parents in early childhood and were subsequently adopted (ELA, n  = 18). No difference was observed in telomere length or in methylation levels of age-related CpGs in whole blood, containing a heterogeneous mixture of immune cells. However, when specifically investigating T cells, we found a higher expression of senescence markers (CD57) in ELA. In addition, senescent T cells (CD57 + ) in ELA had an increased cytolytic potential compared to senescent cells in controls. With a mediation analysis we demonstrated that cytomegalovirus (CMV) infection, which is an important driving force of immunosenescence, largely accounted for elevated CD57 expression observed in ELA. Leukocyte telomere length may obscure cell-specific immunosenescence; here, we demonstrated that the use of cell surface markers of senescence can be more informative. Our data suggest that ELA may increase the risk of CMV infection in early childhood, thereby mediating the effect of ELA on T cell-specific immunosenescence. Thus, future studies should include CMV as a confounder or selectively investigate CMV seronegative cohorts.

T Cell Immunosenescence after Early Life Adversity: Association with Cytomegalovirus Infection

PubMed Central

Elwenspoek, Martha M. C.; Sias, Krystel; Hengesch, Xenia; Schaan, Violetta K.; Leenen, Fleur A. D.; Adams, Philipp; Mériaux, Sophie B.; Schmitz, Stephanie; Bonnemberger, Fanny; Ewen, Anouk; Schächinger, Hartmut; Vögele, Claus; Muller, Claude P.; Turner, Jonathan D.

2017-01-01

Early life adversity (ELA) increases the risk for multiple age-related diseases, such as diabetes type 2 and cardiovascular disease. As prevalence is high, ELA poses a major and global public health problem. Immunosenescence, or aging of the immune system, has been proposed to underlie the association between ELA and long-term health consequences. However, it is unclear what drives ELA-associated immunosenescence and which cells are primarily affected. We investigated different biomarkers of immunosenescence in a healthy subset of the EpiPath cohort. Participants were either parent-reared (Ctrl, n = 59) or had experienced separation from their parents in early childhood and were subsequently adopted (ELA, n = 18). No difference was observed in telomere length or in methylation levels of age-related CpGs in whole blood, containing a heterogeneous mixture of immune cells. However, when specifically investigating T cells, we found a higher expression of senescence markers (CD57) in ELA. In addition, senescent T cells (CD57+) in ELA had an increased cytolytic potential compared to senescent cells in controls. With a mediation analysis we demonstrated that cytomegalovirus (CMV) infection, which is an important driving force of immunosenescence, largely accounted for elevated CD57 expression observed in ELA. Leukocyte telomere length may obscure cell-specific immunosenescence; here, we demonstrated that the use of cell surface markers of senescence can be more informative. Our data suggest that ELA may increase the risk of CMV infection in early childhood, thereby mediating the effect of ELA on T cell-specific immunosenescence. Thus, future studies should include CMV as a confounder or selectively investigate CMV seronegative cohorts. PMID:29089944

A New Image Processing and GIS Package

NASA Technical Reports Server (NTRS)

Rickman, D.; Luvall, J. C.; Cheng, T.

1998-01-01

The image processing and GIS package ELAS was developed during the 1980's by NASA. It proved to be a popular, influential and powerful in the manipulation of digital imagery. Before the advent of PC's it was used by hundreds of institutions, mostly schools. It is the unquestioned, direct progenitor or two commercial GIS remote sensing packages, ERDAS and MapX and influenced others, such as PCI. Its power was demonstrated by its use for work far beyond its original purpose, having worked several different types of medical imagery, photomicrographs of rock, images of turtle flippers and numerous other esoteric imagery. Although development largely stopped in the early 1990's the package still offers as much or more power and flexibility than any other roughly comparable package, public or commercial. It is a huge body or code, representing more than a decade of work by full time, professional programmers. The current versions all have several deficiencies compared to current software standards and usage, notably its strictly command line interface. In order to support their research needs the authors are in the process of fundamentally changing ELAS, and in the process greatly increasing its power, utility, and ease of use. The new software is called ELAS II. This paper discusses the design of ELAS II.

ELaNa - Educational Launch of Nanosatellite Enhance Education Through Space Flight

NASA Technical Reports Server (NTRS)

Skrobot, Garrett Lee

2011-01-01

One of NASA's missions is to attract and retain students in the science, technology, engineering and mathematics (STEM) disciplines. Creating missions or programs to achieve this important goal helps strengthen NASA and the nation's future work force as well as engage and inspire Americans and the rest of the world. During the last three years, in an attempt to revitalize educational space flight, NASA generated a new and exciting initiative. This initiative, NASA's Educational Launch of Nanosatellite (ELaNa), is now fully operational and producing exciting results. Nanosatellites are small secondary satellite payloads called CubeSats. One of the challenges that the CubeSat community faced over the past few years was the lack of rides into space. Students were building CubeSats but they just sat on the shelf until an opportunity arose. In some cases, these opportunities never developed and so the CubeSat never made it to orbit. The ELaNa initiative is changing this by providing sustainable launch opportunities for educational CubeSats. Across America, these CubeSats are currently being built by students in high school all the way through graduate school. Now students know that if they build their CubeSat, submit their proposal and are selected for an ELaNa mission, they will have the opportunity to fly their satellite. ELaNa missions are the first educational cargo to be carried on expendable launch vehicles (ELY) for NASA's Launch Services Program (LSP). The first ELaNa CubeSats were slated to begin their journey to orbit in February 2011 with NASA's Glory mission. Due to an anomaly with the launch vehicle, ELaNa II and Glory failed to reach orbit. This first ELaNa mission was comprised of three IU CubeSats built by students at Montana State University (Explorer Prime Flight 1), the University of Colorado (HERMES), and Kentucky Space, a consortium of state universities (KySat). The interface between the launch vehicle and the CubeSat, the Poly-Picosatellite Orbital Deployer (P-POD), was developed and built by students at California Polytechnic State University (Cal Poly). Integrating a P-POD on a NASA ELV was not an easy task. The creation of new processes and requirements as well as numerous reviews and approvals were necessary within NASA before the first ELaNa mission could be attached to a NASA launch vehicle (LV). One of the key objectives placed on an ELaNa mission is that the CubeSat and PPOD does not increase the baseline risk to the primary mission and launch vehicle. The ELaNa missions achieve this objective by placing a rigorous management and engineering process on both the LV and CubeSat teams. So, what is the future of ELaNa? Currently there are 16 P-POD missions manifested across four launch vehicles to support educational CubeSats selected under the NASA CubeSat Initiative. From this initiative, a rigorous selection process produced 22-student CubeSat missions that are scheduled to fly before the end of 2012. For the initiative to continue, organizations need to submit proposals to the annual CubeSat initiative call so they have the opportunity to be manifested and launched.

ELAS: A powerful, general purpose image processing package

NASA Technical Reports Server (NTRS)

Walters, David; Rickman, Douglas

1991-01-01

ELAS is a software package which has been utilized as an image processing tool for more than a decade. It has been the source of several commercial packages. Now available on UNIX workstations it is a very powerful, flexible set of software. Applications at Stennis Space Center have included a very wide range of areas including medicine, forestry, geology, ecological modeling, and sonar imagery. It remains one of the most powerful image processing packages available, either commercially or in the public domain.

Development of an ELA-DRA gene typing method based on pyrosequencing technology.

PubMed

Díaz, S; Echeverría, M G; It, V; Posik, D M; Rogberg-Muñoz, A; Pena, N L; Peral-García, P; Vega-Pla, J L; Giovambattista, G

2008-11-01

The polymorphism of equine lymphocyte antigen (ELA) class II DRA gene had been detected by polymerase chain reaction-single-strand conformational polymorphism (PCR-SSCP) and reference strand-mediated conformation analysis. These methodologies allowed to identify 11 ELA-DRA exon 2 sequences, three of which are widely distributed among domestic horse breeds. Herein, we describe the development of a pyrosequencing-based method applicable to ELA-DRA typing, by screening samples from eight different horse breeds previously typed by PCR-SSCP. This sequence-based method would be useful in high-throughput genotyping of major histocompatibility complex genes in horses and other animal species, making this system interesting as a rapid screening method for animal genotyping of immune-related genes.

Medical Imaging System

NASA Technical Reports Server (NTRS)

1991-01-01

The MD Image System, a true-color image processing system that serves as a diagnostic aid and tool for storage and distribution of images, was developed by Medical Image Management Systems, Huntsville, AL, as a "spinoff from a spinoff." The original spinoff, Geostar 8800, developed by Crystal Image Technologies, Huntsville, incorporates advanced UNIX versions of ELAS (developed by NASA's Earth Resources Laboratory for analysis of Landsat images) for general purpose image processing. The MD Image System is an application of this technology to a medical system that aids in the diagnosis of cancer, and can accept, store and analyze images from other sources such as Magnetic Resonance Imaging.

Effects of early life adversity on cortisol/salivary alpha-amylase symmetry in free-ranging juvenile rhesus macaques.

PubMed

Petrullo, Lauren A; Mandalaywala, Tara M; Parker, Karen J; Maestripieri, Dario; Higham, James P

2016-11-01

Early life adversity (ELA) affects physiological and behavioral development. One key component is the relationship between the developing Hypothalamic-Pituitary-Adrenal (HPA) axis and the Sympathetic Nervous System (SNS). Recent studies suggest a relationship between early life adversity and asymmetry in cortisol (a measure of HPA activation) and salivary alpha-amylase (sAA: a correlate of SNS activation) responses to stress among human children, but to our knowledge there have been no comparable studies in nonhumans. Here, we investigate the responses of these two analytes in "low stress" and "high stress" situations in free-ranging juvenile rhesus macaques (Macaca mulatta) on Cayo Santiago, Puerto Rico. Behavioral data on maternal maltreatment were collected during the first 3months of life to determine individual rates of ELA, and saliva samples were collected from subjects noninvasively during juvenility. Irrespective of ELA, salivary alpha-amylase levels were lower in low stress situations and higher in high stress situations. For cortisol however, high ELA subjects exhibited higher low stress concentrations and blunted acute responses during high stress situations compared to moderate and low ELA subjects. Cortisol and sAA values were positively correlated among low ELA subjects, suggesting symmetry, but were uncorrelated or negatively correlated among moderate and high ELA subjects, suggesting asymmetry in these individuals. These findings indicate dysregulation of the stress response among juveniles maltreated during infancy: specifically, attenuated cortisol reactivity coupled with typical sAA reactivity characterize the stress response profiles of juveniles exposed to higher rates of ELA during the first 3months of life. Copyright © 2016 Elsevier Inc. All rights reserved.

Two Arabidopsis cytochrome P450 monooxygenases, CYP714A1 and CYP714A2, function redundantly in plant development through gibberellin deactivation.

PubMed

Zhang, Yingying; Zhang, Baichen; Yan, Dawei; Dong, Weixin; Yang, Weibing; Li, Qun; Zeng, Longjun; Wang, Jianjun; Wang, Linyou; Hicks, Leslie M; He, Zuhua

2011-07-01

The rice gene ELONGATED UPPERMOST INTERNODE1 (EUI1) encodes a P450 monooxygenase that epoxidizes gibberellins (GAs) in a deactivation reaction. The Arabidopsis genome contains a tandemly duplicated gene pair ELA1 (CYP714A1) and ELA2 (CYP714A2) that encode EUI homologs. In this work, we dissected the functions of the two proteins. ELA1 and ELA2 exhibited overlapping yet distinct gene expression patterns. We showed that while single mutants of ELA1 or ELA2 exhibited no obvious morphological phenotype, simultaneous elimination of ELA1 and ELA2 expression in ELA1-RNAi/ela2 resulted in increased biomass and enlarged organs. By contrast, transgenic plants constitutively expressing either ELA1 or ELA2 were dwarfed, similar to those overexpressing the rice EUI gene. We also discovered that overexpression of ELA1 resulted in a severe dwarf phenotype, while overexpression of ELA2 gave rise to a breeding-favored semi-dwarf phenotype in rice. Consistent with the phenotypes, we found that the ELA1-RNAi/ela2 plants increased amounts of biologically active GAs that were decreased in the internodes of transgenic rice with ELA1 and ELA2 overexpression. In contrast, the precursor GA(12) slightly accumulated in the transgenic rice, and GA(19) highly accumulated in the ELA2 overexpression rice. Taken together, our study strongly suggests that the two Arabidopsis EUI homologs subtly regulate plant growth most likely through catalyzing deactivation of bioactive GAs similar to rice EUI. The two P450s may also function in early stages of the GA biosynthetic pathway. Our results also suggest that ELA2 could be an excellent tool for molecular breeding for high yield potential in cereal crops. © 2011 The Authors. The Plant Journal © 2011 Blackwell Publishing Ltd.

Climate Reconstructions of the Younger Dryas: An ELA Model Investigating Variability in ELA Depressions, Temperature, and Precipitation Changes for the Graubϋnden Alps

NASA Astrophysics Data System (ADS)

Keeler, D. G.; Rupper, S.; Schaefer, J. M.; Finkel, R. C.

2015-12-01

The high sensitivity of mountain glaciers to even small perturbations in climate, combined with a near global distribution, make alpine glaciers an important target for terrestrial paleoclimate reconstructions. The geomorphic remnant of past glaciers can yield important insights into past climate, particularly in regions where other methods of reconstruction are not possible. The quantitative conversion of these changes in geomorphology to a climate signal, however, presents a significant challenge. A particular need exists for a versatile climate reconstruction method applicable to diverse glacierized regions around the globe. Because the glacier equilibrium line altitude (ELA) provides a more explicit comparison of climate than properties such as glacier length or area, ELA methods lend themselves well to such a need, and allow for a more direct investigation of the primary drivers of mountain glaciations during specific events. Here, we present an ELA model for quantifying changes in climate based on changes in glacier extent, while accounting for differences in glacier width, glacier shape, bed topography, ice thickness, and glacier length. The model furthermore provides bounds on the ΔELA using Monte Carlo simulations. These methods are validated using published mass balances and ELA measurements from 4 modern glaciers in the European Alps. We then use this ELA model, combined with a surface mass and energy balance model, to estimate the changes in temperature/precipitation between the Younger Dryas (constrained by 10Be surface exposure ages) and the present day for three glacier systems in the Graubϋnden Alps. Our results indicate an ELA depression in this area of 257 m ±45 m during the Younger Dryas (YD) relative to today. This corresponds to a 1.3 °C ±0.36 °C decrease in temperature or a 156% ±30% increase in precipitation relative to today. These results indicate the likelihood of a predominantly temperature-driven change rather than a strong dependence on precipitation. We apply these same methods to additional areas around the globe to obtain preliminary, self-consistent estimates of temperature/precipitation for multiple regions. These methods and results enhance our understanding of the global and regional patterns in the climate system during the YD.

Analyzing Sustainable Energy Opportunities for a Small Scale Off-Grid Facility: A Case Study at Experimental Lakes Area (ELA), Ontario

NASA Astrophysics Data System (ADS)

Duggirala, Bhanu

This thesis explored the opportunities to reduce energy demand and renewable energy feasibility at an off-grid science "community" called the Experimental Lakes Area (ELA) in Ontario. Being off-grid, ELA is completely dependent on diesel and propane fuel supply for all its electrical and heating needs, which makes ELA vulnerable to fluctuating fuel prices. As a result ELA emits a large amount of greenhouse gases (GHG) for its size. Energy efficiency and renewable energy technologies can reduce energy consumption and consequently energy cost, as well as GHG. Energy efficiency was very important to ELA due to the elevated fuel costs at this remote location. Minor upgrades to lighting, equipment and building envelope were able to reduce energy costs and reduce load. Efficient energy saving measures were recommended that save on operating and maintenance costs, namely, changing to LED lights, replacing old equipment like refrigerators and downsizing of ice makers. This resulted in a 4.8% load reduction and subsequently reduced the initial capital cost for biomass by 27,000, by 49,500 for wind power and by 136,500 for solar power. Many alternative energies show promise as potential energy sources to reduce the diesel and propane consumption at ELA including wind energy, solar heating and biomass. A biomass based CHP system using the existing diesel generators as back-up has the shortest pay back period of the technologies modeled. The biomass based CHP system has a pay back period of 4.1 years at 0.80 per liter of diesel, as diesel price approaches $2.00 per liter the pay back period reduces to 0.9 years, 50% the generation cost compared to present generation costs. Biomass has been successfully tried and tested in many off-grid communities particularly in a small-scale off-grid setting in North America and internationally. Also, the site specific solar and wind data show that ELA has potential to harvest renewable resources and produce heat and power at competitive rates compared to diesel and propane.

A Novel Candidate Molecule in Pathological Grading Of Gliomas: ELABELA.

PubMed

Artas, Gokhan; Ozturk, Sait; Kuloglu, Tuncay; Dagli, Adile Ferda; Gonen, Murat; Artas, Hakan; Aydin, Suleyman; Erol, Fatih Serhat

2018-04-06

This study aimed to investigate the possible role of ELABELA (ELA) in the histopathological grading of gliomas. We retrospectively assessed pathological specimens of patients who underwent surgery for intracranial space-occupying lesions. Only primary glioma specimens were included in this study. We enrolled 11 patients histologically diagnosed with low-grade glioma and 22 patients with high-grade glioma. The ELA antibody was applied to 4-6-µm-thick sections obtained from paraffin blocks. Histoscores were calculated using the distribution and intensity of staining immunoreactivity. An independent sample t-test was used for two-point inter-group assessments, whereas one-way analysis of variance was used for the other assessments. P 0.05 was considered statistically significant. The histoscores of the control brain, low-grade glioma, and high-grade glioma tissues were found to be 0.08, 0.37, and 0.92, respectively. The difference in ELA immunoreactivity between the control brain tissue and glioma tissue was statistically significant (p 0.05). In addition, a statistically significant increase was observed in ELA immunoreactivity in high-grade glioma tissues compared with that in low-grade glioma tissues (p 0.05). ELA has an angiogenetic role in the progression of glial tumors. ELA, which is an endogenous ligand of the apelin receptor, activates the apelinergic system and causes the progression of glial tumors. Further studies with a large number of patients are necessary to investigate the angiogenetic role of ELA in glial tumors.

Effects of Early-Life Adversity on Hippocampal Structures and Associated HPA Axis Functions.

PubMed

Dahmen, Brigitte; Puetz, Vanessa B; Scharke, Wolfgang; von Polier, Georg G; Herpertz-Dahlmann, Beate; Konrad, Kerstin

2018-01-01

Early-life adversity (ELA) is one of the major risk factors for serious mental and physical health risks later in life. ELA has been associated with dysfunctional neurodevelopment, especially in brain structures such as the hippocampus, and with dysfunction of the stress system, including the hypothalamic-pituitary-adrenal (HPA) axis. Children who have experienced ELA are also more likely to suffer from mental health disorders such as depression later in life. The exact interplay of aberrant neurodevelopment and HPA axis dysfunction as risks for psychopathology is not yet clear. We investigated volume differences in the bilateral hippocampus and in stress-sensitive hippocampal subfields, behavior problems, and diurnal cortisol activity in 24 children who had experienced documented ELA (including out-of-home placement) in a circumscribed duration of adversity only in their first 3 years of life in comparison to data on 25 control children raised by their biological parents. Hippocampal volumes and stress-sensitive hippocampal subfields (Cornu ammonis [CA]1, CA3, and the granule-cell layer of the dentate gyrus [GCL-DG]) were significantly smaller in children who had experienced ELA, taking psychiatric diagnoses and dimensional psychopathological symptoms into account. ELA moderated the relationship between left hippocampal volume and cortisol: in the control group, hippocampal volumes were not related to diurnal cortisol, while in ELA children, a positive linear relationship between left hippocampal volume and diurnal cortisol was present. Our findings show that ELA is associated with altered development of the hippocampus, and an altered relationship between hippocampal volume and HPA axis activity in youth in care, even after they have lived in stable and caring foster family environments for years. Altered hippocampal development after ELA could thus be associated with a risk phenotype for the development of psychiatric disorders later in life. © 2017 S. Karger AG, Basel.

Topographic context of glaciers and perennial snowfields, Glacier National Park, Montana

NASA Astrophysics Data System (ADS)

Allen, Thomas R.

1998-01-01

Equilibrium-line altitudes (ELAs) of modem glaciers in the northern Rocky Mountains are known to correspond with regional climate, but strong subregional gradients such as across the Continental Divide in Glacier National Park, Montana, also exert topoclimatic influences on the ELA. This study analyzed the relationships between glacier and snowfield morphology, ELA, and surrounding topography. Glaciers and perennial snowfields were mapped using multitemporal satellite data from the Landsat Thematic Mapper and aerial photography within an integrated Geographic Information System (GIS). Relationships between glacier morphology and ELA were investigated using discriminant analysis. Four morphological categories of perennial snow and ice patches were identified: cirque glacier, niche glacier, ice cap, and snowfield. ELA was derived from overlaid glacier boundaries and Digital Elevation Models (DEMs) within the GIs. DEMs provided topographic variables and models of solar radiation and wind exposure/shelteredness. Regression analysis showed the effects of exposure; on snow accumulation, the strong influence of local topography through upslope zone morphology such as cirque backwalls, and the tendency for glaciers with high ELAs to exhibit compactness in morphology. Results highlight the relatively compact shape and larger area of glaciers adjacent to the Continental Divide. Discriminant analysis correctly predicted the type of glacier morphology in more than half the observations using factored variables of glacier shape, elevation range, and upslope area.

H and Au diffusion in high mobility a-InGaZnO thin-film transistors via low temperature KrF excimer laser annealing

NASA Astrophysics Data System (ADS)

Bermundo, Juan Paolo S.; Ishikawa, Yasuaki; Fujii, Mami N.; Ikenoue, Hiroshi; Uraoka, Yukiharu

2017-03-01

We report the fabrication of high mobility amorphous InGaZnO (a-IGZO) thin-film transistors (TFTs) irradiated by a single shot of a 248 nm KrF excimer laser. Very high mobilities (μ) of up to 43.5 cm2/V s were obtained after the low temperature excimer laser annealing (ELA) process. ELA induces high temperatures primarily in the upper layers and maintains very low temperatures of less than 50 °C in the substrate region. Scanning Transmission Electron micrographs show no laser induced damage and clear interfaces after the laser irradiation. In addition, several characterization studies were performed to determine the μ improvement mechanism. The analysis of Secondary Ion Mass Spectrometry and X-ray Photoelectron Spectroscopy suggests incorporation of H mainly from the hybrid passivation layer into the channel. Moreover, Energy-dispersive X-ray Spectroscopy results show that Au diffused into the channel after ELA. Both KrF ELA-induced H and Au diffusion contributed to the higher μ. These results demonstrate that ELA can greatly enhance the electrical properties of a-IGZO TFTs for promising applications in large area, transparent, and flexible electronics.

Enhanced electrical and optical properties of room temperature deposited Aluminium doped Zinc Oxide (AZO) thin films by excimer laser annealing

NASA Astrophysics Data System (ADS)

El hamali, S. O.; Cranton, W. M.; Kalfagiannis, N.; Hou, X.; Ranson, R.; Koutsogeorgis, D. C.

2016-05-01

High quality transparent conductive oxides (TCOs) often require a high thermal budget fabrication process. In this study, Excimer Laser Annealing (ELA) at a wavelength of 248 nm has been explored as a processing mechanism to facilitate low thermal budget fabrication of high quality aluminium doped zinc oxide (AZO) thin films. 180 nm thick AZO films were prepared by radio frequency magnetron sputtering at room temperature on fused silica substrates. The effects of the applied RF power and the sputtering pressure on the outcome of ELA at different laser energy densities and number of pulses have been investigated. AZO films deposited with no intentional heating at 180 W, and at 2 mTorr of 0.2% oxygen in argon were selected as the optimum as-deposited films in this work, with a resistivity of 1×10-3 Ω.cm, and an average visible transmission of 85%. ELA was found to result in noticeably reduced resistivity of 5×10-4 Ω.cm, and enhancing the average visible transmission to 90% when AZO is processed with 5 pulses at 125 mJ/cm2. Therefore, the combination of RF magnetron sputtering and ELA, both low thermal budget and scalable techniques, can provide a viable fabrication route of high quality AZO films for use as transparent electrodes.

Effect of Genetic Variant in BICC1 on Functional and Structural Brain Changes in Depression

PubMed Central

Bermingham, Rachel; Carballedo, Angela; Lisiecka, Danuta; Fagan, Andrew; Morris, Derek; Fahey, Ciara; Donohoe, Gary; Meaney, James; Gill, Michael; Frodl, Thomas

2012-01-01

Genes and early-life adversity (ELA) interactively increase the risk of developing major depressive disorder (MDD). A recent genome-wide association study suggests that the minor T-allele of single-nucleotide polymorphisms in the bicaudal C homolog 1 gene (BICC1) has a protective role against MDD. The aims of the study were to investigate whether the minor T-allele of BICC1 is protective against hippocampal structural brain changes, whether it is associated with increased functional brain activity in the emotion regulation system, and how ELA would modify this association. Forty-four patients with MDD and 44 healthy controls were investigated using structural magnetic resonance imaging (MRI) and functional MRI with an emotion inhibition task. Analysis of a single-nucleotide polymorphism in the BICC1-1 (rs999845) gene was performed. Right hippocampal bodies of patients and controls without a history of ELA and who carry the protective T-allele of BICC1 were significantly larger compared with those participants homozygous for the major C-allele of BICC1. However, MDD patients with ELA, who carry the T-allele, had smaller hippocampal head volumes compared with MDD patients without ELA. FMRI showed that patients and controls carrying the protective T-allele of BICC1 activate the emotion regulation system significantly more compared with those participants homozygous for the major C-allele (p<0.05, family wise error corrected). These results are suggestive that the minor T-allele of BICC1 has a protective role against MDD and its known structural and functional brain changes. However, this protective effect seems to be lost in the case of co-occurrence of ELA. PMID:22910460

ELaNa - Educational Launch of Nanosatellite Providing Routine RideShare Opportunities

NASA Technical Reports Server (NTRS)

Skrobot, Garrett Lee; Coelho, Roland

2012-01-01

Since the creation of the NASA CubeSat Launch Initiative (NCSLI), the need for CubeSat rideshares has dramatically increased. After only three releases of the initiative, a total of 66 CubeSats now await launch opportunities. So, how is this challenge being resolved? NASA's Launch Services Program (LSP) has studied how to integrate PPODs on Athena, Atlas V, and Delta IV launch vehicles and has been instrumental in developing several carrier systems to support CubeSats as rideshares on NASA missions. In support of the first two ELaNa missions the Poly-Picosatellite Orbital Deployer (P-POD) was adapted for use on a Taurus XL (ELaNa I) and a Delta n (ELaNa III). Four P-PODs, which contained a total eight CubeSats, were used on these first ELaNa missions. Next up is ELaNa VI, which will launch on an Atlas V in August 2012. The four ELaNa VI CubeSats, in three P-PODs, are awaiting launch, having been integrated in the NPSCuLite. To increase rideshare capabilities, the Launch Services Program (LSP) is working to integrate P-PODs on Falcon 9 missions. The proposed Falcon 9 manifest will provide greater opportunities for the CubeSat community. For years, the standard CubeSat size was 1 U to 3U. As the desire to include more science in each cube grows, so does the standard CubeSat size. No longer is a 1 U, 1.5U, 2U or 3U CubeSat the only option available; the new CubeSat standard will include 6U and possibly even 12U. With each increase in CubeSat size, the CubeSat community is pushing the capability of the current P-POD design. Not only is the carrier system affected, but integration to the Launch Vehicle is also a concern. The development of a system to accommodate not only the 3U P-POD but also carriers for larger CubeSats is ongoing. LSP considers payloads in the lkg to 180 kg range rideshare or small/secondary payloads. As new and emerging small payloads are developed, rideshare opportunities and carrier systems need to be identified and secured. The development of a rideshare carrier system is not always cost effective. Sometimes a launch vehicle with an excellent performance record appears to be a great rideshare candidate however, after completing a feasibility study, LSP may determine that the cost of the rideshare carrier system is too great and, due to budget constraints, the development cannot go forward. With the current budget environment, one cost effective way to secure rideshare opportunities is to look for synergy with other government organizations that share the same interest.

ELABELA Improves Cardio-Renal Outcome in Fatal Experimental Septic Shock.

PubMed

Coquerel, David; Chagnon, Frédéric; Sainsily, Xavier; Dumont, Lauralyne; Murza, Alexandre; Côté, Jérôme; Dumaine, Robert; Sarret, Philippe; Marsault, Éric; Salvail, Dany; Auger-Messier, Mannix; Lesur, Olivier

2017-11-01

Apelin-13 was recently proposed as an alternative to the recommended β-adrenergic drugs for supporting endotoxin-induced myocardial dysfunction. Since Apelin-13 signals through its receptor (Apelin peptide jejunum) to exert singular inotropic/vasotropic actions and to optimize body fluid balance, this candidate pathway might benefit septic shock management. Whether the newly discovered ELABELA (ELA), a second endogenous ligand of the Apelin peptide jejunum receptor highly expressed in the kidney, further improves cardio-renal impairment remains unknown. Interventional study in a rat model of septic shock (128 adult males) to assess the effects of ELA and Apelin-13 on vascular and cardio-renal function. Experiments were performed in a tertiary care University-based research institute. Polymicrobial sepsis-induced cardiac dysfunction was produced by cecal ligation puncture to assess hemodynamic efficacy, cardioprotection, and biomechanics under acute or continuous infusions of the apelinergic agonists ELA or Apelin-13 (39 and 15 µg/kg/hr, respectively) versus normal saline. Apelinergic agonists improved 72-hour survival after sepsis induction, with ELA providing the best clinical outcome after 24 hours. Apelinergic agonist infusion counteracted cecal ligation puncture-induced myocardial dysfunction by improving left ventricular pressure-volume relationship. ELA-treated cecal ligation puncture rats were the only group to 1) display a significant improvement in left ventricular filling as shown by increased E-wave velocity and left ventricular end-diastolic volume, 2) exhibit a higher plasma volume, and 3) limit kidney injury and free-water clearance. These beneficial renal effects were superior to Apelin-13, likely because full-length ELA enabled a distinctive regulation of pituitary vasopressin release. Activation of the apelinergic system by exogenous ELA or Apelin-13 infusion improves cardiovascular function and survival after cecal ligation puncture-induced sepsis. However, ELA proved better than Apelin-13 by improving fluid homeostasis, cardiovascular hemodynamics recovery, and limiting kidney dysfunction in a vasopressinergic-dependent manner.

Challenge '95 - The Ariane 5 Development Programme

NASA Astrophysics Data System (ADS)

Vedrenne, M.; van Gaver, M.

1987-10-01

The Ariane-5 launcher has been assigned to the following types of missions: (1) launching geostationary and sun-synchronous commercial satellites, and scientific and trial applications satellites; (2) launching the Hermes spaceplane, and (3) launching elements of the Columbus system such as the man-tended free-flyer module, and the polar platform. A new launch complex, the ELA-3, is being built for the Ariane-5 launcher close to ESA's ELA-1 and ELA-2 launch complexes at Kourou. After two qualification flights in the automatic version in 1995 (501 and 502), it is expected that Ariane-5 will be declared operational with its first commercial flight planned for early 1996 to put an automatic payload into orbit.

Sustained ELABELA Gene Therapy in High-salt Diet-induced Hypertensive Rats.

PubMed

Schreiber, Claire A; Holditch, Sara J; Generous, Alex; Ikeda, Yasuhiro

2017-01-01

Elabela (ELA) is a recently identified apelin receptor agonist essential for cardiac development, but its biology and therapeutic potential are unclear. In humans, ELA transcripts are detected in embryonic stem cells, induced pluripotent stem cells, kidney, heart and blood vessels. ELA through the apelin (APJ) receptor promotes angiogenesis in vitro, relaxes murine aortic blood vessels and attenuates high blood pressure in vivo. The APJ receptor when bound to its original ligand, apelin, exerts peripheral vasodilatory and positive inotropic effects, conferring cardioprotection in vivo. This study initially assessed endogenous ELA expression in normal and diseased rats and then characterized the effects of long-term ELA gene delivery by adeno-associated virus serotype 9 (AAV9) vectors on cardiorenal function in Dahl salt-sensitive rats (DS) on a high-salt diet over 3 months. Endogenous ELA was predominantly expressed in the kidneys, especially in the renal collecting duct cells and was not affected by disease. Rat ELA was overexpressed in the heart via AAV9 vector by a single intravenous injection. ELA-treated animals showed delayed onset of blood pressure elevation. Prior to high-salt diet, a reduction in the fractional sodium and chloride excretion was observed in rats given the AAV9-ELA vector. After three months on a high-salt diet, ELA preserved glomerular architecture, decreased renal fibrosis and suppressed expression of fibrosis-associated genes in the kidneys. ELA is constitutively expressed in renal collecting ducts in rats. Sustained AAV-ELA expression may offer a potential long-term therapy for hypertension and renal remodeling. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

ELABELA Is an Endogenous Growth Factor that Sustains hESC Self-Renewal via the PI3K/AKT Pathway.

PubMed

Ho, Lena; Tan, Shawn Y X; Wee, Sheena; Wu, Yixuan; Tan, Sam J C; Ramakrishna, Navin B; Chng, Serene C; Nama, Srikanth; Szczerbinska, Iwona; Sczerbinska, Iwona; Chan, Yun-Shen; Avery, Stuart; Tsuneyoshi, Norihiro; Ng, Huck Hui; Gunaratne, Jayantha; Dunn, N Ray; Reversade, Bruno

2015-10-01

ELABELA (ELA) is a peptide hormone required for heart development that signals via the Apelin Receptor (APLNR, APJ). ELA is also abundantly secreted by human embryonic stem cells (hESCs), which do not express APLNR. Here we show that ELA signals in a paracrine fashion in hESCs to maintain self-renewal. ELA inhibition by CRISPR/Cas9-mediated deletion, shRNA, or neutralizing antibodies causes reduced hESC growth, cell death, and loss of pluripotency. Global phosphoproteomic and transcriptomic analyses of ELA-pulsed hESCs show that it activates PI3K/AKT/mTORC1 signaling required for cell survival. ELA promotes hESC cell-cycle progression and protein translation and blocks stress-induced apoptosis. INSULIN and ELA have partially overlapping functions in hESC medium, but only ELA can potentiate the TGFβ pathway to prime hESCs toward the endoderm lineage. We propose that ELA, acting through an alternate cell-surface receptor, is an endogenous secreted growth factor in human embryos and hESCs that promotes growth and pluripotency. Copyright © 2015 Elsevier Inc. All rights reserved.

Impact of Angioscopic Evaluation for Femoropopliteal In-Stent Restenosis Before and After Excimer Laser Atherectomy.

PubMed

Idemoto, Akiko; Okamoto, Naotaka; Tanaka, Akihiro; Mori, Naoki; Nakamura, Daisuke; Yano, Masamichi; Makino, Nobuhiko; Egami, Yasuyuki; Shutta, Ryu; Tanouchi, Jun; Nishino, Masami

2017-07-01

In-stent restenosis (ISR) is a prevalent problem following stenting of femoropopliteal lesions. A potential novel treatment modality for ISR including excimer laser atherectomy (ELA) has become available. We performed ELA for in-stent chronic total occlusion (CTO) of femoropopliteal lesions and evaluated lesion morphology before and after ELA by angioscopy in 2 patients. The angioscopic findings clearly showed removal of in-stent thrombi after ELA. Thus, ELA may be effective for in-stent CTO of femoropopliteal lesions. This is the first report describing the direct visualization of ELA effect for vaporization of thrombi in femoropopliteal in-stent lesions by angioscopy.

Sex differences in stress-induced visceral hypersensitivity following early life adversity: a two hit model.

PubMed

Prusator, D K; Greenwood-Van Meerveld, B

2016-12-01

Early life adversity (ELA) has been indicated as a risk factor for the development of stress axis dysfunction in adulthood, specifically in females. We previously showed that unpredictable ELA induces visceral hyperalgesia in adult female rats. It remains to be determined whether ELA alters visceral nociceptive responses to stress in adulthood. The current study tested the hypothesis that following ELA, exposure to an adulthood stressor, or second hit, serves as a risk factor for exaggerated stress-induced visceral hypersensitivity that is sex-specific. Following ELA, adult stress was induced via a single exposure (acute) or repetitive daily exposure, 1 h/day for 7 days (chronic), to water avoidance stress (WAS). Acute WAS increased pain behaviors in all adult female rats, however, females that experienced unpredictable ELA exhibited significantly more pain behaviors compared to those exposed to predictable ELA or controls. Following chronic WAS, all adult females exhibited increased pain responses, however, an exaggerated response was observed in rats exposed to unpredictable or predictable ELA compared to controls. Similarly, in adult male rats exposure to acute or chronic WAS increased pain behaviors, however, there were no differences in pain behaviors between ELA groups. This study highlights a novel consequence of ELA on stress-induced visceral nociception in adulthood that is sex-specific. More importantly, our study suggests that ELA not only serves as a risk factor for development of chronic pain in adulthood, but also serves as a predisposition for worsening of visceral pain following adult stress in female rats. © 2016 John Wiley & Sons Ltd.

A clinical study to evaluate the efficacy of ELA-Max (4% liposomal lidocaine) as compared with eutectic mixture of local anesthetics cream for pain reduction of venipuncture in children.

PubMed

Eichenfield, Lawrence F; Funk, Ann; Fallon-Friedlander, Sheila; Cunningham, Bari B

2002-06-01

A double-randomized, blinded crossover trial was performed to assess the efficacy of ELA-Max (4% liposomal lidocaine) as compared with eutectic mixture of local anesthetics (EMLA) for pain relief during pediatric venipuncture procedures. Safety was assessed by evaluation for topical or systemic effects and measurement of serum lidocaine concentrations. A total of 120 children who were scheduled for repeat venipuncture for non-study-related reasons at 2 sites participated in the study. Patients were doubly randomized to treatment regimen (study medication application time of either 30 or 60 minutes) and to the order of application of the topical anesthetics for each venipuncture. The primary outcome measures were the child's rating of pain immediately after the venipuncture procedures using a 100-mm visual analog scale (VAS) tool and the parent's and blinded research observer's Observed Behavioral Distress scores. Both ELA-Max and EMLA seemed to alleviate venipuncture pain. There was no clinically or statistically significant difference in the patient VAS scores within the 30-minute or 60-minute treatment groups, and there was no clinical or statistical difference in VAS scores between the 30-minute ELA-Max treatment without occlusion and the 60-minute EMLA treatment with occlusion. There were no clinically or statistically significant differences between treatment with ELA-Max and EMLA in parental or blinded researcher Observed Behavioral Distress scores, the most frequent response at any observation time being "no distress." This study demonstrates that a 30-minute application of ELA-Max without occlusion is as safe and as effective for ameliorating pain associated with venipuncture as a 60-minute application of the prescription product EMLA requiring occlusion.

Career Advancement, Career Enhancement, and Personal Growth of Pepperdine University's Educational Leadership Academy Graduate Program Alumni

ERIC Educational Resources Information Center

Nichols, Ruth I.

2012-01-01

The purpose of this phenomenological study was two-fold: (a) to explore and describe the perceived impact of Pepperdine University's Educational Leadership Academy (ELA) on 2003-2006 ELA graduates' career advancement, career enhancement, and personal growth; and (b) to obtain ELA graduates' suggestions for ELA program improvement to better prepare…

Glacial reorganization of topography in a tectonically active mountain range

NASA Astrophysics Data System (ADS)

Adams, Byron; Ehlers, Todd

2016-04-01

Tests of the interactions between tectonic and climate forcing on Earth's topography often focus on the concept of steady-state whereby processes of rock deformation and erosion are opposing and equal. However, when conditions change such as the climate or tectonic rock uplift, then surface processes act to restore the balance between rock deformation and erosion by adjusting topography. Most examples of canonical steady-state mountain ranges lie within the northern hemisphere, which underwent a radical change in the Quaternary due to the onset of widespread glaciation. The activity of glaciers changed erosion rates and topography in many of these mountain ranges, which likely violates steady-state assumptions. With new topographic analysis, and existing patterns of climate and rock uplift, we explore a mountain range previously considered to be in steady-state, the Olympic Mountains, USA. The details of our analysis suggest the dominant topographic signal in the Olympic Mountains is a spatial, and likely temporal, variation in erosional efficiency dictated by orographic precipitation, and Pleistocene glacier ELA patterns, and not tectonic rock uplift rates. Alpine glaciers drastically altered the relief structure of the Olympic Mountains. The details of these relief changes are recorded in channel profiles as overdeepenings, reduced slopes, and associated knickpoints. We find the position of these relief changes within the orogen is dependent on the position of the Pleistocene ELA. While alpine glaciers overdeepened valleys in regions near the Pleistocene ELA (which has a tendency to increase relief), headward erosion of west and north flowing glacier systems captured significant area from opposing systems and caused drainage divide lowering. This divide lowering reduced relief throughout the range. We demonstrate similar topographic effects recorded in the basin hypsometries of other Cenozoic mountain ranges around the world. The significant glacial overprint on topography makes the argument of mountain range steadiness untenable in significantly glaciated settings. Furthermore, our results suggest that most glaciated Cenozoic ranges are likely still in a mode of readjustment as fluvial systems change topography and erosion rates to equilibrate with rock uplift rates.

Reconstructed glacier geometry and inferred Equilibrium Line Altitude changes during the Late Pleistocene deglaciation in the Retezat Mountains, Southern Carpathians

NASA Astrophysics Data System (ADS)

Madarász, Balázs; Ruszkiczay-Rüdiger, Zsófia; Kern, Zoltán; Urdea, Petru

2016-04-01

Quaternary glaciations had a major imprint on the landscape and topography of the Southern Carpathians. Their transitional position between continental and Mediterranean climate zones arouses special interest concerning the timing and pattern of glaciations in this area. Probably the Retezat Mts hosted the most extended glaciation during the Late Pleistocene within this range. The peak elevations of the study area reach 2500 m asl, and the most extended glaciers descended to 1040 m in the northern and to 1130 m on the southern valleys. Major cirque floors are typically situated at 2000-2100 m asl. Glacial landforms have been mapped in order to reconstruct the past ice bodies and the elevation shifts of the paleo equilibrium line altitudes (ELA) during several deglaciation phases of the Last Glacial Maximum (LGM) and Lateglacial in the Retezat Mts. On the basis of published 10Be exposure age data on the northern valleys of the study area, deglaciation of the Retezat Mts occurred at least in five phases between ~21.0 ka and 13.5 ka [1]. Various methods (THAR, AAR, AABR) have been tested using a GIS tool to estimate the ELA of the reconstructed paleoglaciers [2] and paleo ELAs were calculated for each of the deglaciation phases. Preliminary estimates of regional LGM paleoELA employing the simplest THAR method (with a ratio of 0.5) ranged from ~1670 m during the LGM to ~2210 m for the smallest cirque glacier at 13.5 ka, respectively. The AAR and AABR methods provide somewhat higher ELAs for each phase. The obtained paleoELAs were compared to ELA reconstructions available from other Carpathian ranges and also to the Alps and Dinarides. Our data will contribute to a more accurate ELA distribution during the LGM, which may be indicative of the past state of the climate system (moisture gradient, circulation regimes). Thanks to OTKA PD83610, PD104899; NKM-96/2014, NKM-31/2015; OMAA 90öu17; LP2012-27/2012. References: [1] Ruszkiczay-Rüdiger et al. 2016 Quat. Int. (in press) doi:10.1016/j.quaint.2015.10.085 [2] Pellitero et al. 2015 Computers & Geosciences 82: 55-62

Recent changes in equilibrium line altitudes of glaciers in the Chandra-Bhaga Catchments, the Western Himalaya

NASA Astrophysics Data System (ADS)

Kumari, R.; Vijay, S.; Banerjee, A.; Singh, G.

2017-12-01

Abstract: Climatic forcing affects a glacier through a change in the corresponding equilibrium line altitude (ELA). Many approximate methods are available in the literature for estimating ELA of glaciers that are in a steady state. Some of the rudimentary methods e.g. Toe-to-Headwall-Ratio method or mid-point elevation methods are based solely on the elevation range of the glacier cover, and ignore the variations in slope, valley width or the mass-balance profile. The mean-elevation method is more accurate in that it takes into account the glacier hypsometry. In this study, we extend this method to estimate the ELA of a glacier that is not in a steady state. We assume a linear mass-balance profile, and utilize geodetic mass balance and hypsometry of the glacier to obtain ELA. This method is generally useful to track, for example, the spatial pattern of recent ELA changes in a given region. We apply the above method to 46 debris-free glaciers in the Chandra-Bhaga catchments, the Western Himalaya, to understand the regional ELA forcing during 2000 to 2012. Shuttle Radar Topographic Mission (2000) and TanDEM-X (2012) digital elevation model (DEM) are used to get elevation data. A strong correlation (r2=0.90 and p<0.001) of the estimated ELAs with the corresponding end-of-summer-snowline-elevation data derived from cloud-free Landsat images validates our method. Our estimate for the recent ELA of Chhota shigri Glacier from the region are consistent with published glaciological ELA values. On a regional scale, the estimated ELAs are negatively correlated (r2= 0.66 and p<0.001) with the mean Tropical Rainfall Measuring Mission (TRMM 2b31) precipitation data. This implies a strong control of local precipitation on glacier mass balance profile, with 18 +/- 2 m rise of ELA per 10 mm/year reduction in rainfall. We shall also discuss the regional patterns of the changes in transient ELA between 2000 and 2012.

Def1 interacts with TFIIH and modulates RNA polymerase II transcription.

PubMed

Damodaren, Nivedita; Van Eeuwen, Trevor; Zamel, Joanna; Lin-Shiao, Enrique; Kalisman, Nir; Murakami, Kenji

2017-12-12

The DNA damage response is an essential process for the survival of living cells. In a subset of stress-responsive genes in humans, Elongin controls transcription in response to multiple stimuli, such as DNA damage, oxidative stress, and heat shock. Yeast Elongin (Ela1-Elc1), along with Def1, is known to facilitate ubiquitylation and degradation of RNA polymerase II (pol II) in response to multiple stimuli, yet transcription activity has not been examined. We have found that Def1 copurifies from yeast whole-cell extract with TFIIH, the largest general transcription factor required for transcription initiation and nucleotide excision repair. The addition of recombinant Def1 and Ela1-Elc1 enhanced transcription initiation in an in vitro reconstituted system including pol II, the general transcription factors, and TFIIS. Def1 also enhanced transcription restart from TFIIS-induced cleavage in a pol II transcribing complex. In the Δdef1 strain, heat shock genes were misregulated, indicating that Def1 is required for induction of some stress-responsive genes in yeast. Taken together, our results extend the understanding of the molecular mechanism of transcription regulation on cellular stress and reveal functional similarities to the mammalian system.

The curvilinear relationship of early-life adversity and successful aging: the mediating role of mental health.

PubMed

Höltge, Jan; Mc Gee, Shauna L; Thoma, Myriam V

2018-02-15

The steeling effect suggests that early-life adversity can have a beneficial impact later in life. However, little is known about its underlying mechanisms and long-term outcomes . The study aimed to examine the role of early-life adversity (ELA) on successful aging, and whether this relationship can be explained by mental and physical health. Socio-demographics, early-life adversity (ELA), individual quality of life (iQoL), and mental and physical health of 270 individuals (M age = 66.82 years, 71.5% female) were assessed. Polynomial regressions and mediation analyses were conducted. Significant inverse U-shaped associations were found between ELA and iQoL (β = -.59, p = .005) and between ELA and mental health (β = -.64, p = .002), but not between ELA and physical health. Furthermore, mental health significantly mediated the relationship between ELA and iQoL (b = -.84, BCa CI [-1.66, -.27]). Highest level of individual quality of life (i.e. successful aging) was related to a moderate amount of ELA. Additionally, mental health significantly mediated this relationship. These findings suggest that some amount of ELA could be beneficial for successful aging. Resource-focused interventions are needed to improve health and promote successful aging for an underdetected, at-risk subgroup with low early-life adversity.

Allogeneic major histocompatibility complex-mismatched equine bone marrow-derived mesenchymal stem cells are targeted for death by cytotoxic anti-major histocompatibility complex antibodies.

PubMed

Berglund, A K; Schnabel, L V

2017-07-01

Allogeneic mesenchymal stem cells (MSCs) are a promising cell source for treating musculoskeletal injuries in horses. Controversy exists, however, over whether major histocompatibility complex (MHC)-mismatched MSCs are recognised by the recipient immune system and targeted for death by a cytotoxic antibody response. To determine if cytotoxic anti-MHC antibodies generated in vivo following MHC-mismatched MSC injections are capable of initiating complement-dependent cytotoxicity of MSCs. Experimental controlled study. Antisera previously collected at Days 0, 7, 14 and 21 post-injection from 4 horses injected with donor MHC-mismatched equine leucocyte antigen (ELA)-A2 haplotype MSCs and one control horse injected with donor MHC-matched ELA-A2 MSCs were utilised in this study. Antisera were incubated with ELA-A2 MSCs before adding complement in microcytotoxicity assays and cell death was analysed via eosin dye exclusion. ELA-A2 peripheral blood leucocytes (PBLs) were used in the assays as a positive control. Antisera from all 4 horses injected with MHC-mismatched MSCs contained antibodies that caused the death of ELA-A2 haplotype MSCs in the microcytotoxicity assays. In 2 of the 4 horses, antibodies were present as early as Day 7 post-injection. MSC death was consistently equivalent to that of ELA-A2 haplotype PBL death at all time points and antisera dilutions. Antisera from the control horse that was injected with MHC-matched MSCs did not contain cytotoxic ELA-A2 antibodies at any of the time points examined. This study examined MSC death in vitro only and utilized antisera from a small number of horses. The cytotoxic antibody response induced in recipient horses following injection with donor MHC-mismatched MSCs is capable of killing donor MSCs in vitro. These results suggest that the use of allogeneic MHC-mismatched MSCs must be cautioned against, not only for potential adverse events, but also for reduced therapeutic efficacy due to targeted MSC death. © 2016 The Authors Equine Veterinary Journal published by John Wiley & Sons Ltd on behalf of EVJ Ltd.

Calculation of former ELA depressions in the Himalaya - a comparative analysis

NASA Astrophysics Data System (ADS)

Wagner, M.

2009-04-01

For the reconstruction of former Equilibrium Line Altitudes (ELA) and ELA depressions in the Himalaya, the group of the Toe-to-Summit-Altitude-Methods (TSAM) is most suited. In this investigation the Kuhle (1986) method that is particularly tailored to the extreme high mountain relief, as well as the widely used Höfer (1879) method and Louis (1954/55) method, have been applied. Applying the relief specific correction factor FSD (Factor for snowline deviation) in the Kuhle method, it is thereby possible to simulate the shifting position of the ELA within the vertical extension of the glacier in dependence on the relief characteristics and glacial type. The results of this work, carried out along the Kali Gandaki in central Nepal, illustrate that as a rule, the Louis method results in the highest ELAs and the lowest ELA depressions, while the Höfer method yields the lowest ELAs and the highest ELA depressions. In affirmation of the literature, the Louis method tends to overestimate the ELA, since using the maximum peak height, especially for large glaciers in mountain ranges with high relief energy, leads to an overly high position of the glacier upper limit. With respect to the Höfer method, the suspicion already voiced by Höfer (1879) himself, that with the use of his method, the for the Himalaya typically high elevated, and with marginal gradient toward the valley moving ridge progressions, would lead to a too low ELA, can be affirmed. Clearly to be disputed, however, is the statement of Gross et al. (1976) that the Höfer method leads to an overestimation of the ELA. The reason for this can be found in a wrong computation of the mean ridge height above the ELA and consequently of the ELA itself within the Höfer method, based on the erroneous assumption that otherwise the ELA could not be calculated due to a circular conclusion (Gross et al. 1976). As is evidenced by this study, the Kuhle method mediates between the empiric overly high values of the Louis method and the overly low values of the Höfer method, because of a mediating definition of the accumulation zone upper limit. Additionally, over the FSD, Kuhle allows for a high degree of adaptation to the extreme Himalaya relief, and within limitations from the change of the relief constellation, which stems from transverse valley's characteristics of the Kali Gandaki. Therefore, the results of the Kuhle method must be affirmed as reflecting the greatest conformity with the actual values of the ELA and the ELA depression. References: Gross, G., H. Kerschner, G. Patzelt (1976): Methodische Untersuchungen über die Schneegrenze in alpinen Gletschergebieten. Zeitschrift für Gletscherkunde und Glazialgeologie 12 (2): 223-251. Höfer von Heimhalt, H. (1879): Gletscher- und Eiszeitstudien. Sitzungsberichte der Akademie der Wissenschaften in Wien, Mathematisch-Naturwissenschaftliche Klasse, Abteilung I, Biologie, Mineralogie, Erdkunde 79: 331-367. Kuhle, M. (1986): Schneegrenzberechnung und typologische Klassifikation von Gletschern anhand spezifischer Reliefparameter. Petermanns Geographische Mitteilungen 130: 41-51. Louis, H. (1954/55): Schneegrenze und Schneegrenzbestimmung. Geographisches Taschenbuch 1954/55: 414-418.

Effects of PDGF-BB delivery from heparinized collagen sutures on the healing of lacerated chicken flexor tendon in vivo.

PubMed

Younesi, Mousa; Knapik, Derrick M; Cumsky, Jameson; Donmez, Baris Ozgur; He, Ping; Islam, Anowarul; Learn, Greg; McClellan, Philip; Bohl, Michael; Gillespie, Robert J; Akkus, Ozan

2017-11-01

Flexor tendon lacerations are traditionally repaired by using non-absorbable monofilament sutures. Recent investigations have explored to improve the healing process by growth factor delivery from the sutures. However, it is difficult to conjugate growth factors to nylon or other synthetic sutures. This study explores the performance of a novel electrochemically aligned collagen suture in a flexor tendon repair model with and without platelet derived growth factor following complete tendon laceration in vivo. Collagen suture was fabricated via electrochemical alignment process. Heparin was covalently bound to electrochemically aligned collagen sutures (ELAS) to facilitate affinity bound delivery of platelet-derived growth factor-BB (PDGF-BB). Complete laceration of the flexor digitorum profundus in the third digit of the foot was performed in 36 skeletally mature White Leghorn chickens. The left foot was used as the positive control. Animals were randomly divided into three groups: control specimens treated with standard nylon suture (n=12), specimens repaired with heparinated ELAS suture without PDGF-BB (n=12) and specimens repaired with heparinated ELAS suture with affinity bound PDGF-BB (n=12). Specimens were harvested at either 4weeks or 12weeks following tendon repair. Differences between groups were evaluated by the degree of gross tendon excursion, failure load/stress, stiffness/modulus, absorbed energy at failure, elongation/strain at failure. Quantitative histological scoring was performed to assess cellularity and vascularity. Closed flexion angle measurements demonstrated no significant differences in tendon excursion between the study groups at 4 or 12weeks. Biomechanical testing showed that the group treated with PDGF-BB bound heparinated ELAS suture had significantly higher stiffness and failure load (p<0.05) at 12-weeks relative to both heparinated ELAS suture and nylon suture. Similarly, the group treated with PDGF-BB bound suture had significantly higher ultimate tensile strength and Young's modulus (p<0.05) at 12-weeks relative to both ELAS suture and nylon suture. Compared to nylon controls, heparinized ELAS with PDGF-BB improved biomechanics and vascularity during tendon healing by 12-weeks following primary repair. The ability of ELAS to deliver PDGF-BB to the lacerated area of tendon presents investigators with a functional bioinductive platform to improve repair outcomes following flexor tendon repair. A high strength aligned collagen suture was fabricated via linear electrocompaction and heparinized for prolonged delivery of PDFG-BB. When it was used to suture a complete lacerated flexor tendon in a chicken model controlled release of the PDGF-BB improved the strength of treated tendon after 12 weeks compared to tendon sutured with commercial nylon suture. Furthermore, Collagen suture with affinity bound PDGF-BB enhanced the vascularization and remodeling of lacerated tendon when it compare to synthetic nylon suture. Overall, electrocompacted collagen sutures holds potential to improve repair outcome in flexor tendon surgeries by improving repair strength and stiffness, vascularity, and remodeling via sustained delivery of the PDGF-BB. The bioinductive collagen suture introduces a platform for sustained delivery of other growth factors for a wide-array of applications. Copyright © 2017 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Sexually dimorphic effects of unpredictable early life adversity on visceral pain behavior in a rodent model.

PubMed

Chaloner, Aaron; Greenwood-Van Meerveld, Beverley

2013-03-01

Visceral pain is the hallmark feature of irritable bowel syndrome (IBS), a gastrointestinal disorder, which is more commonly diagnosed in women. Female IBS patients frequently report a history of early life adversity (ELA); however, sex differences in ELA-induced visceral pain and the role of ovarian hormones have yet to be investigated. Therefore, we tested the hypothesis that ELA induces visceral hypersensitivity through a sexually dimorphic mechanism mediated via estradiol. As a model of ELA, neonatal rats were exposed to different pairings of an odor and shock to control for trauma predictability. In adulthood, visceral sensitivity was assessed via a visceromotor response to colorectal distension. Following ovariectomy and estradiol replacement in a separate group of rats, the visceral sensitivity was quantified. We found that females that received unpredictable odor-shock developed visceral hypersensitivity in adulthood. In contrast, visceral sensitivity was not significantly different following ELA in adult males. Ovariectomy reversed visceral hypersensitivity following unpredictable ELA, whereas estradiol replacement reestablished visceral hypersensitivity in the unpredictable group. This study is the first to show sex-related differences in visceral sensitivity following unpredictable ELA. Our data highlight the activational effect of estradiol as a pivotal mechanism in maintaining visceral hypersensitivity. This article directly implicates a critical role for ovarian hormones in maintaining visceral hypersensitivity following ELA, specifically identifying the activational effect of estradiol as a key modulator of visceral sensitivity. These data suggest that ELA induces persistent functional abdominal pain in female IBS patients through an estrogen-dependent mechanism. Copyright © 2013 American Pain Society. All rights reserved.

Spatial variability and trends in Younger Dryas equilibrium line altitudes across the European Alps using a hypsometrically based ELA model: results and implications

NASA Astrophysics Data System (ADS)

Keeler, D. G.; Rupper, S.; Schaefer, J. M.; Finkel, R. C.; Maurer, J. M.

2016-12-01

Alpine glaciers constitute an important component of terrestrial paleoclimate records due to, among other characteristics, their high sensitivity to climate change, near global extent, and their integration of myriad climate variables into a single, easily detected signal. Because the glacier equilibrium line altitude (ELA) provides a more explicit representation of climate than many other glacier properties, ELA methods allow for more direct comparisons of multiple glaciers within or between regions. Such comparisons allow for more complete investigations of the ultimate causes of mountain glaciation during specific events. Many studies however tend to focus on a limited number of sites, and employ a large variety of different techniques for ELA reconstruction between studies, making wider climate implications more tenuous. Methods of ELA reconstruction that can be rapidly and consistently applied to an arbitrary number of paleo-glaciers would provide a more accurate portrayal of the changes in climate across a given region. Here we present ELA reconstructions from Egesen Stadial moraines across the European Alps using an ELA model accounting for differences in glacier width, glacier shape, bed topography, ice thickness, and glacier length, including several glaciers constrained to the Younger Dryas using surface exposure dating techniques. We compare reconstructed Younger Dryas ELA values to modern ELA values using the same model, or using end of summer snowline estimates where no glacier is currently present. We further provide uncertainty estimates on the ΔELA using bootstrapped Monte Carlo simulations for the various input parameters. Preliminary results compare favorably to previous glacier studies of the European Younger Dryas, but provide greater context from many glaciers across the region as a whole. Such results allow for a more thorough investigation of the spatial variability and trends in climate during the Younger Dryas across the European Alps, and comparisons of other regions in the future.

Elastase-2, a Tissue Alternative Pathway for Angiotensin II Generation, Plays a Role in Circulatory Sympathovagal Balance in Mice

PubMed Central

Becari, Christiane; Durand, Marina T.; Guimaraes, Alessander O.; Lataro, Renata M.; Prado, Cibele M.; de Oliveira, Mauro; Candido, Sarai C. O.; Pais, Paloma; Ribeiro, Mauricio S.; Bader, Michael; Pesquero, Joao B.; Salgado, Maria C. O.; Salgado, Helio C.

2017-01-01

In vitro and ex vivo experiments indicate that elastase-2 (ELA-2), a chymotrypsin-serine protease elastase family member 2A, is an alternative pathway for angiotensin II (Ang II) generation. However, the role played by ELA-2 in vivo is unclear. We examined ELA-2 knockout (ELA-2KO) mice compared to wild-type (WT) mice and determined whether ELA-2 played a role in hemodynamics [arterial pressure (AP) and heart rate (HR)], cardiocirculatory sympathovagal balance and baroreflex sensitivity. The variability of systolic arterial pressure (SAP) and pulse interval (PI) for evaluating autonomic modulation was examined for time and frequency domains (spectral analysis), whereas a symbolic analysis was also used to evaluate PI variability. In addition, baroreflex sensitivity was examined using the sequence method. Cardiac function was evaluated echocardiographically under anesthesia. The AP was normal whereas the HR was reduced in ELA-2KO mice (425 ± 17 vs. 512 ± 13 bpm from WT). SAP variability and baroreflex sensitivity were similar in both strains. The LF power from the PI spectrum (33.6 ± 5 vs. 51.8 ± 4.8 nu from WT) and the LF/HF ratio (0.60 ± 0.1 vs. 1.45 ± 0.3 from WT) were reduced, whereas the HF power was increased (66.4 ± 5 vs. 48.2 ± 4.8 nu from WT) in ELA-2KO mice, indicating a shift toward parasympathetic modulation of HR. Echocardiographic examination showed normal fractional shortening and an ejection fraction in ELA-2KO mice; however, the cardiac output, stroke volume, and ventricular size were reduced. These findings provide the first evidence that ELA-2 acts on the sympathovagal balance of the heart, as expressed by the reduced sympathetic modulation of HR in ELA-2KO mice. PMID:28386233

Elastase-2, a Tissue Alternative Pathway for Angiotensin II Generation, Plays a Role in Circulatory Sympathovagal Balance in Mice.

PubMed

Becari, Christiane; Durand, Marina T; Guimaraes, Alessander O; Lataro, Renata M; Prado, Cibele M; de Oliveira, Mauro; Candido, Sarai C O; Pais, Paloma; Ribeiro, Mauricio S; Bader, Michael; Pesquero, Joao B; Salgado, Maria C O; Salgado, Helio C

2017-01-01

In vitro and ex vivo experiments indicate that elastase-2 (ELA-2), a chymotrypsin-serine protease elastase family member 2A, is an alternative pathway for angiotensin II (Ang II) generation. However, the role played by ELA-2 in vivo is unclear. We examined ELA-2 knockout (ELA-2KO) mice compared to wild-type (WT) mice and determined whether ELA-2 played a role in hemodynamics [arterial pressure (AP) and heart rate (HR)], cardiocirculatory sympathovagal balance and baroreflex sensitivity. The variability of systolic arterial pressure (SAP) and pulse interval (PI) for evaluating autonomic modulation was examined for time and frequency domains (spectral analysis), whereas a symbolic analysis was also used to evaluate PI variability. In addition, baroreflex sensitivity was examined using the sequence method. Cardiac function was evaluated echocardiographically under anesthesia. The AP was normal whereas the HR was reduced in ELA-2KO mice (425 ± 17 vs. 512 ± 13 bpm from WT). SAP variability and baroreflex sensitivity were similar in both strains. The LF power from the PI spectrum (33.6 ± 5 vs. 51.8 ± 4.8 nu from WT) and the LF/HF ratio (0.60 ± 0.1 vs. 1.45 ± 0.3 from WT) were reduced, whereas the HF power was increased (66.4 ± 5 vs. 48.2 ± 4.8 nu from WT) in ELA-2KO mice, indicating a shift toward parasympathetic modulation of HR. Echocardiographic examination showed normal fractional shortening and an ejection fraction in ELA-2KO mice; however, the cardiac output, stroke volume, and ventricular size were reduced. These findings provide the first evidence that ELA-2 acts on the sympathovagal balance of the heart, as expressed by the reduced sympathetic modulation of HR in ELA-2KO mice.

Mississippi Company Using NASA Software Program to Provide Unique Imaging Service: DATASTAR Success Story

NASA Technical Reports Server (NTRS)

2001-01-01

DATASTAR, Inc., of Picayune, Miss., has taken NASA's award-winning Earth Resources Laboratory Applications (ELAS) software program and evolved it to the point that the company is now providing a unique, spatial imagery service over the Internet. ELAS was developed in the early 80's to process satellite and airborne sensor imagery data of the Earth's surface into readable and useable information. While there are several software packages on the market that allow the manipulation of spatial data into useable products, this is usually a laborious task. The new program, called the DATASTAR Image Processing Exploitation, or DIPX, Delivery Service, is a subscription service available over the Internet that takes the work out of the equation and provides normalized geo-spatial data in the form of decision products.

Climatic implications of reconstructed early - Mid Pliocene equilibrium-line altitudes in the McMurdo Dry Valleys, Antarctica

USGS Publications Warehouse

Krusic, A.G.; Prentice, M.L.; Licciardi, J.M.

2009-01-01

Early-mid Pliocene moraines in the McMurdo Dry Valleys, Antarctica, are more extensive than the present alpine glaciers in this region, indicating substantial climatic differences between the early-mid Pliocene and the present. To quantify this difference in the glacier-climate regime, we estimated the equilibrium-line altitude (ELA) change since the early-mid Pliocene by calculating the modern ELA and reconstructing the ELAs of four alpine glaciers in Wright and Taylor Valleys at their early-mid Pliocene maxima. The area-altitude balance ratio method was used on modern and reconstructed early-mid Pliocene hypsometry. In Wright and Victoria Valleys, mass-balance data identify present-day ELAs of 800-1600 m a.s.l. and an average balance ratio of 1.1. The estimated ELAs of the much larger early-mid Pliocene glaciers in Wright and Taylor Valleys range from 600 to 950 ?? 170 m a.s.l., and thus are 250-600 ??170 m lower than modern ELAs in these valleys. The depressed ELAs during the early-mid-Pliocene most likely indicate a wetter and therefore warmer climate in the Dry Valleys during this period than previous studies have recognized.

Early life adversity and/or posttraumatic stress disorder severity are associated with poor diet quality, including consumption of trans fatty acids, and fewer hours of resting or sleeping in a US middle-aged population: A cross-sectional and prospective study.

PubMed

Gavrieli, Anna; Farr, Olivia M; Davis, Cynthia R; Crowell, Judith A; Mantzoros, Christos S

2015-11-01

Early life adversity (ELA) and post-traumatic stress disorder (PTSD) are associated with poorer psychological and physical health. Potential underlying mechanisms and mediators remain to be elucidated, and the lifestyle habits and characteristics of individuals with ELA and/or PTSD have not been fully explored. We investigated whether the presence of ELA and/or PTSD are associated with nutrition, physical activity, resting and sleeping and smoking. A cross-sectional sample of 151 males and females (age: 45.6±3.5 years, BMI: 30.0±7.1 kg/m(2)) underwent anthropometric measurements, as well as detailed questionnaires for dietary assessment, physical activity, resting and sleeping, smoking habits and psychosocial assessments. A prospective follow-up visit of 49 individuals was performed 2.5 years later and the same outcomes were assessed. ELA and PTSD were evaluated as predictors, in addition to a variable assessing the combined presence/severity of ELA-PTSD. Data were analyzed using analysis of covariance after adjusting for several socioeconomic, psychosocial and anthropometric characteristics. Individuals with higher ELA or PTSD severity were found to have a poorer diet quality (DASH score: p=0.006 and p=0.003, respectively; aHEI-2010 score: ELA p=0.009), including further consumption of trans fatty acids (ELA p=0.003); the differences were significantly attenuated null after adjusting mainly for education or income and/or race. Further, individuals with higher ELA severity reported less hours of resting and sleeping (p=0.043) compared to those with zero/lower ELA severity, and the difference remained significant in the fully adjusted model indicating independence from potential confounders. When ELA and PTSD were combined, an additive effect was observed on resting and sleeping (p=0.001); results remained significant in the fully adjusted model. They also consumed more energy from trans fatty acids (p=0.017) tended to smoke more (p=0.008), and have less physical activity (PTSD p=0.024) compared to those with no or lower ELA and PTSD severity. Adjustments for sociodemographic factors and/or BMI rendered results of the above lifestyle parameters non-significant. The analysis of the prospective data showed similar trends to the cross-sectional analysis, further supporting the conclusions, although statistical significance of results was lower due to the lower number of participants. Fewer hours of resting and sleeping and poorer diet quality are linked to ELA and/or PTSD, indicating that these pathways might underlie the development of several metabolic abnormalities in individuals with ELA and/or PTSD. Differences in terms of diet quality are significantly attenuated by race and/or education and/or income, whereas differences in other lifestyle habits of individuals with and without ELA and/or PTSD, such as physical activity, are mostly explained by confounding sociodemographic variables and/or body mass index. Copyright © 2015 Elsevier Inc. All rights reserved.

Early life adversity is associated with a smaller hippocampus in male but not female depressed in-patients: a case-control study.

PubMed

Colle, Romain; Segawa, Tomoyuki; Chupin, Marie; Tran Dong, Minh Ngoc Thien Kim; Hardy, Patrick; Falissard, Bruno; Colliot, Olivier; Ducreux, Denis; Corruble, Emmanuelle

2017-02-15

Three studies assessed the association of early life adversity (ELA) and hippocampal volumes in depressed patients, of which one was negative and the two others did not control for several potential confounding variables. Since the association of ELA and hippocampal volumes differ in male and female healthy volunteers, we investigated the association of ELA and hippocampal volumes in depressed patients, while focusing specifically on sex and controlling for several relevant socio-demographic and clinical variables. Sixty-three depressed in-patients treated in a psychiatric setting, with a current Major Depressive Episode (MDE) and a Major Depressive Disorder (MDD) were included and assessed for ELA. Hippocampal volumes were measured with brain magnetic resonance imaging (MRI) and automatic segmentation. They were compared between patients with (n = 28) or without (n = 35) ELA. After bivariate analyses, multivariate regression analyses tested the interaction of sex and ELA on hippocampal volume and were adjusted for several potential confounding variables. The subgroups of men (n = 26) and women (n = 37) were assessed separately. Patients with ELA had a smaller hippocampus than those without ELA (4.65 (±1.11) cm 3 versus 5.25 (±1.01) cm 3 ), bivariate: p = 0.03, multivariate: HR = 0.40, 95%CI [0.23;0.71], p = 0.002), independently from other factors. This association was found in men (4.43 (±1.22) versus 5.67 (±0.77) cm 3 ), bivariate: p = 0.006, multivariate HR = 0.23, 95%CI [0.06;0.82], p = 0.03) but not in women. ELA is associated with a smaller hippocampus in male but not female depressed in-patients. The reasons for this association should be investigated in further studies.

Late Pleistocene equilibrium-line reconstructions in the northern Peruvian Andes

USGS Publications Warehouse

Rodbell, D.T.

1992-01-01

ELA reconstructions using the toe-to-headwall-altitude ratio method for paleoglaciers in the Cordilleras Blanca and Oriental, northern Peruvian Andes indicate that ELAs during the last glacial maximum (LGM; marine isotope stage 2)) were c.4300 m in the Cordillera Blanca, c.3900-3600 m on the west side of the Cordillera Oriental, and c.3200 m on the east (Amazon Basin) side of the Cordillera Oriental. Comparison with estimated modern ELAs and glaciation thresholds indicate that ELA depression ranged from c.700 m in the Cordillera Blanca to c.1200 m on the east side of the Cordillera Oriental. Palynological evidence for drier conditions during the LGM in the tropical Andes suggests that ELA depression of this amount involved a temperature reduction (>5-6??C) that greatly exceeded the tropical sea-surface temperature depression estimates of CLIMAP (<2??C). The west to east increase in ELA depression during the LGM indicates that the steep modern precipitation gradients may have been even steeper during the LGM. -from Author

Recombination Suppression in PbS Quantum Dot Heterojunction Solar Cells by Energy-Level Alignment in the Quantum Dot Active Layers.

PubMed

Ding, Chao; Zhang, Yaohong; Liu, Feng; Nakazawa, Naoki; Huang, Qingxun; Hayase, Shuzi; Ogomi, Yuhei; Toyoda, Taro; Wang, Ruixiang; Shen, Qing

2017-09-22

Using spatial energy-level gradient engineering with quantum dots (QDs) of different sizes to increase the generated carrier collection at the junction of a QD heterojunction solar cell (QDHSC) is a hopeful route for improving the energy-conversion efficiency. However, the results of current related research have shown that a variable band-gap structure in a QDHSC will create an appreciable increase, not in the illumination current density, but rather in the fill factor. In addition, there are a lack of studies on the mechanism of the effect of these graded structures on the photovoltaic performance of QDHSCs. This study presents the development of air atmosphere solution-processed TiO 2 /PbS QDs/Au QDHSCs by engineering the energy-level alignment (ELA) of the active layer via the use of a sorted order of differently sized QD layers (four QD sizes). In comparison to the ungraded device (without the ELA), the optimized graded architecture (containing the ELA) solar cells exhibited a great increase (21.4%) in short-circuit current density (J sc ). As a result, a J sc value greater than 30 mA/cm 2 has been realized in planar, thinner absorption layer (∼300 nm) PbS QDHSCs, and the open-circuit voltage (V oc ) and power-conversion efficiency (PCE) were also improved. Through characterization by the light intensity dependences of the J sc and V oc and transient photovoltage decay, we find that (i) the ELA structure, serving as an electron-blocking layer, reduces the interfacial recombination at the PbS/anode interface, and (ii) the ELA structure can drive more carriers toward the desirable collection electrode, and the additional carriers can fill the trap states, reducing the trap-assisted recombination in the PbS QDHSCs. This work has clearly elucidated the mechanism of the recombination suppression in the graded QDHSCs and demonstrated the effects of ELA structure on the improvement of J sc . The charge recombination mechanisms characterized in this work would be able to shed light on further improvements of QDHSCs, which could even benefit other types of solar cells.

Determining the Current and Future Health of Low-Latitude Andean Glaciers Using an Equilibrium Line Altitude Model and Hypsometric Data from the Randolph Glacier Inventory

NASA Astrophysics Data System (ADS)

Malone, A.; MacAyeal, D. R.

2015-12-01

Mountain glaciers have been described as the water towers of world, and for many populations in the low-latitude South American Andes, glacial runoff is vital for agricultural, industrial, and basic water needs. Previous studies of low-latitude Andean glaciers suggest a precarious future due to contemporary warming. These studies have looked at trends in freezing level heights or observations of contemporary retreat. However, regional-scale understanding of low-latitude glacial responses to present and future climate change is limited, in part due to incomplete information about the extent and elevation distribution of low-latitude glaciers. The recently published Randolph Glacier Inventory (RGI) (5.0) provides the necessary information about the size and elevation distribution of low-latitude glaciers to begin such studies. We determine the contemporary equilibrium line altitudes (ELAs) for low-latitude Andean glaciers in the RGI, using a numerical energy balance ablation model driven with reanalysis and gridded data products. Contemporary ELAs tend to fall around the peak of the elevation histogram, with an exception being the southern-most outer tropical glaciers whose modeled ELAs tend to be higher than the elevation histogram for that region (see below figure). Also, we use the linear tends in temperature and precipitation from the contemporary climatology to extrapolate 21stcentury climate forcings. Modeled ELAs by the middle on the century are universally predicted to rise, with outer tropical ELAs rising more than the inner tropical glaciers. These trends continue through the end of the century. Finally, we explore how climate variables and parameters in our numerical model may vary for different warming scenarios from United Nation's IPCC AR5 report. We quantify the impacts of these changes on ELAs for various climate change trajectories. These results support previous work on the precarious future of low latitude Andean glaciers, while providing a richer understanding of the glacial impacts of contemporary and future warming. Also, this work provides analysis of processes and feedbacks between different climate variables important to glacier mass balances in a warming world, improving predictions for the fate of low-latitude Andean glaciers.

ELA-max: A new topical lidocaine formulation.

PubMed

Goldman, Ran D

2004-05-01

To evaluate the role of a new formulation of lidocaine (ELA-max) in local anesthesia in children and compare it with the eutectic mixture of local anesthetics (EMLA). Relevant literature was identified by a MEDLINE search (1966-November 2003) using the search terms ELA-max and EMLA. Bibliographies of selected articles were also examined to include all relevant investigations. The product manufacturer was contacted for inclusion of the most recent data available. Topical anesthesia in children is clinically challenging. ELA-max has been shown to be as effective as EMLA for venipuncture in children, but with faster onset. Adverse effects, such as transient blanching with redness and erythema, have been reported. Further investigation is needed to determine the effectiveness of ELA-max on other painful procedures in children, as well as its safety.

Fate of Glaciers in the Tibetan Plateau by 2100

NASA Astrophysics Data System (ADS)

Duan, K.

2017-12-01

As the third polar on the Earth, the Tibetan plateau holds more than 40,000 glaciers which have experienced a rapid retreat in recent decades. The variability of equilibrium line altitude (ELA) indicates expansion and wastage of glacier directly. Here we simulated the ELA variability in the Tibetan Plateau based on a full surface energy and mass balance model. The simulation results are agreement with the observations. The ELAs have risen at a rate of 2-8m/a since 1970 throughout the Plateau, especially in the eastern Plateau where the ELAs have risen to or over the top altitude of glacier, indicating the glaciers are accelerating to melting over there. Two glaciers, XD glacier in the center of the Plateau and Qiyi glacier in the Qilian Mountain, are chosen to simulate its future ELA variability in the scenarios of RCP2.6, RCP4.5 and RCP 8.5 given by IPCC. The results show the ELAs will arrive to its maximum in around 2040 in RCP2.6, while the ELAs will be over the top altitude of glaciers in 2035-2045 in RCP4.5 and RCP8.5, suggesting the glaciers in the eastern Plateau will be melting until the disappear of the glaciers by the end of 2100.

Early life adversity and/or posttraumatic stress disorder severity are associated with poor diet quality, including consumption of trans fatty acids, and fewer hours of resting or sleeping in a US middle-aged population: A cross-sectional and prospective study

PubMed Central

Gavrieli, Anna; Farr, Olivia M; Davis, Cynthia R; Crowell, Judith A; Mantzoros, Christos S.

2015-01-01

Background Early life adversity (ELA) and post-traumatic stress disorder (PTSD) are associated with poorer psychological and physical health. Potential underlying mechanisms and mediators remain to be elucidated, and the lifestyle habits and characteristics of individuals with ELA and/or PTSD have not been fully explored. We investigated whether the presence of ELA and/or PTSD are associated with nutrition, physical activity, resting and sleeping and smoking. Methods A cross-sectional sample of 151 males and females (age: 45.6±3.5 y, BMI: 30.0±7.1kg/m2) underwent anthropometric measurements, as well as detailed questionnaires for dietary assessment, physical activity, resting and sleeping, smoking habits and psychosocial assessments. A prospective follow-up visit of 49 individuals was performed 2.5 years later and the same outcomes were assessed. ELA and PTSD were evaluated as predictors, in addition to a variable assessing the combined presence/severity of ELA–PTSD. Data were analyzed using analysis of covariance after adjusting for several socioeconomic, psychosocial and anthropometric characteristics. Results Individuals with higher ELA or PTSD severity were found to have a poorer diet quality (DASH score: p=0.006 and p=0.003, respectively; aHEI-2010 score: ELA p=0.009), including further consumption of trans fatty acids (ELA p=0.003); the differences were significantly attenuated null after adjusting mainly for education or income and/or race. Further, individuals with higher ELA severity reported less hours of resting and sleeping (p=0.043) compared to those with zero/lower ELA severity, and the difference remained significant in the fully adjusted model indicating independence from potential confounders. When ELA and PTSD were combined, an additive effect was observed on resting and sleeping (p=0.001); results remained significant in the fully adjusted model. They also consumed more energy from trans fatty acids (p=0.017) tended to smoke more (p=0.008), and have less physical activity (PTSD p=0.024) compared to those with no or lower ELA and PTSD severity. Adjustments for sociodemographic factors and/or BMI rendered results of the above life style parameters non-significant. The analysis of the prospective data showed similar trends to the cross-sectional analysis, further supporting the conclusions, although statistical significance of results was lower due to the lower number of participants. Conclusion Fewer hours of resting and sleeping and poorer diet quality are linked to ELA and/or PTSD, indicating that these pathways might underlie the development of several metabolic abnormalities in individuals with ELA and/or PTSD. Differences in terms of diet quality are significantly attenuated by race and/or education and/or income, whereas differences in other lifestyle habits of individuals with and without ELA and/or PTSD, such as physical activity, are mostly explained by confounding sociodemographic variables and/or body mass index. PMID:26404481

Risk factors for alcoholism in the Oklahoma Family Health Patterns project: impact of early life adversity and family history on affect regulation and personality.

PubMed

Sorocco, Kristen H; Carnes, Nathan C; Cohoon, Andrew J; Vincent, Andrea S; Lovallo, William R

2015-05-01

This study examined the impact of early lifetime adversity (ELA) on affect regulation and personality in persons with family history (FH+) and without (FH-) a family history of alcoholism. We examined the impact of early life adversity in healthy young adults, 18-30 years of age enrolled in a long-term study on risk for alcohol and other substance abuse. ELA was assessed by a composite score of low socioeconomic status and personal experience of physical or sexual abuse and/or separation from parents before age 16, resulting in a score of 0, 1-2, or >3 adverse events. Unstable affect regulation and personality variables were obtained via self-report measures. Higher ELA scores were seen in FH+ (χ(2)=109.2, p<0.0001) and in women (χ(2)=17.82, p=0.0019). Although higher ELA predicted less emotional stability and more behavioral undercontrol, further analysis including both FH and ELA showed that FH+ persons are prone to poor affect regulation, negative moods, and have risky drinking and drug abuse tendencies independent of ELA level. ELA predicts reduced stress reactivity and poorer cognitive control over impulsive behaviors as shown elsewhere. The present work shows that FH+ have poor mood regulation and antisocial characteristics. The greater prevalence of ELA in FH+ persons indicates that life experience and FH+ work in tandem to result in risky patterns of alcohol and drug experimentation to elevate risk for alcoholism. Further studies of genetic and environmental contributions to alcoholism are called for. Published by Elsevier Ireland Ltd.

Application of the indirect enzyme-labeled antibody microtest to the detection and surveillance of animal diseases. [Brucellosis, cholera, and trichinosis in cattle and swine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Saunders, G.C. Clinard, E.H.; Bartlett, M.L.; Sanders, W.M.

1976-01-01

The rapid, indirect enzyme-labeled antibody (ELA) microplate test has been developed as a diagnostic and surveillance tool to aid in the control of animal disease. Data are presented, which illustrate the application of the test to viral (hog cholera), parasitic (trichinosis), and bacterial (brucellosis) diseases of animals. A greater than 95 percent correlation was observed between the hog cholera ELA test and the hog cholera serum neutralization test performed on over 2000 mixed hog cholera positive and negative field samples obtained during the 1976 New Jersey epizootic. Of 56 swine naturally infected with Trichinella spiralis at a level considered dangerousmore » to man, all were ELA positive, while only one of 360 T. spiralis negative packing house sera was ELA positive. Preliminary experiments with bovine brucellosis (Brucella abortus) indicate that the ELA test is more sensitive than other test methods currently in use. ELA procedures should soon become tests of choice for the detection of antibodies to animal disease agents.« less

The Experimental Lakes Area: Over 45 Years of Whole Ecosystem Monitoring and Manipulation Experiments and a Focus on the Future

NASA Astrophysics Data System (ADS)

Emmerton, C. A.

2015-12-01

The IISD Experimental Lakes Area is a unique facility which has existed since 1968 and consists of 58 lakes and their watersheds set aside for research purposes. The IISD-ELA also boasts an on-site water chemistry lab, accommodations and facilities for up to 60 personnel. Since its inception in 1968 over 50 whole ecosystem experiments have been conducted at the ELA including eutrophication, acidification of lakes, environmental mercury fates, hydro-electric reservoir impacts and much more. The recent partnership between IISD and ELA has allowed ELA to refocus on freshwater research and policy development in a time where the preservation of the earth's most precious resource is of the utmost concern. In addition to water quality monitoring, the ELA is also focused on autotrophic ecology, zooplankton community structures, fish population and behaviour and food-web interactions. Monitoring all of these disciplines and their inter-relationships gives the research facility a unique perspective and along with the long term dataset stretching back to 1968 the ELA can look at historical records to monitor long term changes in the environment.

Hydrologic impacts of changes in climate and glacier extent in the Gulf of Alaska watershed

NASA Astrophysics Data System (ADS)

Beamer, J. P.; Hill, D. F.; McGrath, D.; Arendt, A.; Kienholz, C.

2017-09-01

High-resolution regional-scale hydrologic models were used to quantify the response of late 21st century runoff from the Gulf of Alaska (GOA) watershed to changes in regional climate and glacier extent. NCEP Climate Forecast System Reanalysis data were combined with five Coupled Model Intercomparison Project Phase 5 general circulation models (GCMs) for two representative concentration pathway (RCP) scenarios (4.5 and 8.5) to develop meteorological forcing for the period 2070-2099. A hypsographic model was used to estimate future glacier extent given assumed equilibrium line altitude (ELA) increases of 200 and 400 m. GCM predictions show an increase in annual precipitation of 12% for RCP 4.5 and 21% for RCP 8.5, and an increase in annual temperature of 2.5°C for RCP 4.5 and 4.3°C for RCP 8.5, averaged across the GOA. Scenarios with perturbed climate and glaciers predict annual GOA-wide runoff to increase by 9% for RCP4.5/ELA200 case and 14% for the RCP8.5/ELA400 case. The glacier runoff decreased by 14% for RCP4.5/ELA200 and by 34% for the RCP8.5/ELA400 case. Intermodel variability in annual runoff was found to be approximately twice the variability in precipitation input. Additionally, there are significant changes in runoff partitioning and increases in snowpack runoff are dominated by increases in rain-on-snow events. We present results aggregated across the entire GOA and also for individual watersheds to illustrate the range in hydrologic regime changes and explore the sensitivities of these results by independently perturbing only climate forcings and only glacier cover.

Study on the efficacy of ELA-Max (4% liposomal lidocaine) compared with EMLA cream (eutectic mixture of local anesthetics) using thermosensory threshold analysis in adult volunteers.

PubMed

Tang, M B Y; Goon, A T J; Goh, C L

2004-04-01

ELA-Max and EMLA cream are topical anesthetics that have been shown to have similar anesthetic efficacy in previous studies. To evaluate the analgesic efficacy of ELA-Max in comparison with EMLA cream using a novel method of thermosensory threshold analysis. A thermosensory analyzer was used to assess warmth- and heat-induced pain thresholds. No statistically significant difference was found in pain thresholds using either formulation. However, EMLA cream increased the heat-induced pain threshold to a greater extent than ELA-Max. Thermosensory measurement and analysis was well tolerated and no adverse events were encountered. EMLA cream may be superior to ELA-Max for heat-induced pain. This study suggests that thermosensory measurement may be another suitable tool for future topical anesthetic efficacy studies.

Prospects for use of the ELA test in control of trichinellosis in swine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clinard, E.H.; Saunders, G.C.; Leighty, J.C.

1976-01-01

A practicable system for examining food animals at the time of slaughter to detect the presence of humoral antibodies against diseases of significance to human or animal health would be a valuable adjunct to meat inspection. Trichinosis, which has the characteristics of many of the disease problems that are of interest to the Meat and Poultry Inspection Program, was selected as a model for this purpose. Preliminary work indicated that the enzyme-labeled antibody test (ELA) could be used for detection of antibodies to Trichinella spiralis in swine. Other characteristics of the ELA test, such as its low cost, sensitivity, specificity,more » and potential for automation, supported its further development. The ultimate goal of this work is to provide a rapid, economical, automated test which will identify all swine constituting a human health hazard due to presence of infective T. spiralis larvae at the time of slaughter and identify all animals which have been infected by this parasite.« less

Manipulating the dipole layer of polar organic molecules on metal surfaces via different charge-transfer channels

NASA Astrophysics Data System (ADS)

Lin, Meng-Kai; Nakayama, Yasuo; Zhuang, Ying-Jie; Wang, Chin-Yung; Pi, Tun-Wen; Ishii, Hisao; Tang, S.-J.

The key properties of organic films such as energy level alignment (ELA), work functions, and injection barriers are closely linked to this dipole layer. Using angle resolved photoemission spectroscopy (ARPES), we systemically investigate the coverage-dependent work functions and spectra line shapes of occupied molecular orbital states of a polar molecule, chloroaluminium phthalocyanine (ClAlPc), grown on Ag(111) to show that the orientations of the first ClAlPc layer can be manipulated via the molecule deposition rate and post annealing, causing ELA at organic-metal interface to differ for about 0.3 eV between Cl-up and Cl-down configuration. Moreover, by comparing the experimental results with the calculations based on both gas-phase model and realistic model of ClAlPc on Ag(111) , we evidence that the different orientations of ClAlPc dipole layers lead to different charge-transfer channels between ClAlPc and Ag, a key factor that controls the ELA at organic-metal interface.

Electrical and Structural Analysis on the Formation of n-type Junction in Germanium

NASA Astrophysics Data System (ADS)

Aziz, Umar Abdul; Nadhirah Mohamad Rashid, Nur; Rahmah Aid, Siti; Centeno, Anthony; Ikenoue, Hiroshi; Xie, Fang

2017-05-01

Germanium (Ge) has re-emerged as a potential candidate to replace silicon (Si) as a substrate, due to its higher carrier mobility properties that are the key point for the realization of devices high drive current. However, the fabrication process of Ge is confronted with many problems such as low dopant electrical activation and the utilization of heavy n-type dopant atoms during ion implantation. These problems result in more damage and defects that can affect dopant activation. This paper reports the electrical and structural analysis on the formation of n-type junction in Ge substrate by ion implantation, followed by excimer laser annealing (ELA) using KrF laser. ELA parameters such as laser fluences were varied from 100 - 2000 mJ/cm2 and shot number between 1 - 1000 to obtain the optimized parameter of ELA with a high degree of damage and defect removal. Low resistance with a high degree of crystallinity is obtained for the samples annealed with less than five shot number. Higher shot number with high laser fluence, shows a high degree of ablation damage.

Simulation and prediction of equilibrium line altitude of glaciers in the eastern Tibetan plateau

NASA Astrophysics Data System (ADS)

Duan, Keqin

2017-04-01

As the third polar on the Earth, the Tibetan plateau holds more than 40,000 glaciers which have experienced a rapid retreat in recent decades. Glacier loss has increased concern for water resources around the Tibetan plateau. The variability of equilibrium line altitude (ELA) indicates expansion and wastage of glacier directly. Here we simulated the ELA variability in the eastern Tibetan Plateau based on a full surface energy and mass balance model. The simulation results are agreement with the observations. The ELAs have risen at a rate of 2-8m/a since 1970 throughout the eastern Plateau, especially in the Qilian Mountain and the southeastern Plateau where the ELAs have risen to or over the top altitude of glacier, indicating the glaciers are accelerating to melting over there. Two typical glacier, Xiaodongkemadi glacier in the center of the Plateau and Qiyi glacier in the Qilian Mountain, are chosen to simulate its future ELA variability in the scenarios of RCP2.6, RCP4.5 and RCP 8.5 given by IPCC. The results show the ELAs will arrive to its maximum in around 2040 in the scenario of RCP2.6, while the ELAs will be over the top altitude of glaciers in 2035-2045 in the scenarios of RCP4.5 and RCP8.5, suggesting the glaciers in the eastern plateau will be melting until the disappear of the glaciers.

ptf1a+, ela3l− cells are developmentally maintained progenitors for exocrine regeneration following extreme loss of acinar cells in zebrafish larvae

PubMed Central

Schmitner, Nicole; Kohno, Kenji

2017-01-01

ABSTRACT The exocrine pancreas displays a significant capacity for regeneration and renewal. In humans and mammalian model systems, the partial loss of exocrine tissue, such as after acute pancreatitis or partial pancreatectomy induces rapid recovery via expansion of surviving acinar cells. In mouse it was further found that an almost complete removal of acinar cells initiates regeneration from a currently not well-defined progenitor pool. Here, we used the zebrafish as an alternative model to study cellular mechanisms of exocrine regeneration following an almost complete removal of acinar cells. We introduced and validated two novel transgenic approaches for genetically encoded conditional cell ablation in the zebrafish, either by caspase-8-induced apoptosis or by rendering cells sensitive to diphtheria toxin. By using the ela3l promoter for exocrine-specific expression, we show that both approaches allowed cell-type-specific removal of >95% of acinar tissue in larval and adult zebrafish without causing any signs of unspecific side effects. We find that zebrafish larvae are able to recover from a virtually complete acinar tissue ablation within 2 weeks. Using short-term lineage-tracing experiments and EdU incorporation assays, we exclude duct-associated Notch-responsive cells as the source of regeneration. Rather, a rare population of slowly dividing ela3l-negative cells expressing ptf1a and CPA was identified as the origin of the newly forming exocrine cells. Cells are actively maintained, as revealed by a constant number of these cells at different larval stages and after repeated cell ablation. These cells establish ela3l expression about 4-6 days after ablation without signs of increased proliferation in between. With onset of ela3l expression, cells initiate rapid proliferation, leading to fast expansion of the ela3l-positive population. Finally, we show that this proliferation is blocked by overexpression of the Wnt-signaling antagonist dkk1b. In conclusion, we show a conserved requirement for Wnt signaling in exocrine tissue expansion and reveal a potential novel progenitor or stem cell population as a source for exocrine neogenesis after complete loss of acinar cells. PMID:28138096

Equine allogeneic bone marrow-derived mesenchymal stromal cells elicit antibody responses in vivo.

PubMed

Pezzanite, Lynn M; Fortier, Lisa A; Antczak, Douglas F; Cassano, Jennifer M; Brosnahan, Margaret M; Miller, Donald; Schnabel, Lauren V

2015-04-12

This study tested the hypothesis that Major Histocompatibility Complex (MHC) incompatible equine mesenchymal stromal cells (MSCs) would induce cytotoxic antibodies to donor MHC antigens in recipient horses after intradermal injection. No studies to date have explored recipient antibody responses to allogeneic donor MSC transplantation in the horse. This information is critical because the horse is a valuable species for assessing the safety and efficacy of MSC treatment prior to human clinical application. Six MHC heterozygote horses were identified as non-ELA-A2 haplotype by microsatellite typing and used as allogeneic MHC-mismatched MSC recipients. MHC homozygote horses of known ELA-A2 haplotype were used as MSC and peripheral blood leukocyte (PBL) donors. One MHC homozygote horse of the ELA-A2 haplotype was the recipient of ELA-A2 donor MSCs as an MHC-matched control. Donor MSCs, which were previously isolated and immunophenotyped, were thawed and culture expanded to achieve between 30x10(6) and 50x10(6) cells for intradermal injection into the recipient's neck. Recipient serum was collected and tested for the presence of anti-donor antibodies prior to MSC injection and every 7 days after MSC injection for the duration of the 8-week study using the standard two-stage lymphocyte microcytotoxicity dye-exclusion test. In addition to anti-ELA-A2 antibodies, recipient serum was examined for the presence of cross-reactive antibodies including anti-ELA-A3 and anti-RBC antibodies. All MHC-mismatched recipient horses produced anti-ELA-A2 antibodies following injection of ELA-A2 MSCs and developed a wheal at the injection site that persisted for the duration of the experiment. Anti-ELA-A2 antibody responses were varied both in terms of strength and timing. Four recipient horses had high-titered anti-ELA-A2 antibody responses resulting in greater than 80% donor PBL death in the microcytotoxicity assays and one of these horses also developed antibodies that cross-reacted when tested on lymphocyte targets from a horse with an unrelated MHC type. Allogeneic MSCs are capable of eliciting antibody responses in vivo that can be strong and also cross-reactive with MHC types other than that of the donor. Such responses could limit the effectiveness of repeated allogeneic MSC use in a single horse, and could also result in untoward inflammatory responses in recipients.

Present and former equilibrium-line altitudes near Mount Everest, Nepal and Tibet

USGS Publications Warehouse

Williams, V.S.

1983-01-01

New information on equilibrium-line altitudes (ELAs) of present and former glaciers in the Mount Everest area of eastern Nepal and southern Tibet has been derived from field mapping and interpretation of topographic maps and Landsat imagery. Present ELAs rise from south to north across the Himalayan Range from 5200 to 5800 m, as indicated by the altitudes of lowest cirque glaciers and highest lateral and medial moraines on valley glaciers. In contrast, ELAs during maximum late Pleistocene glaciation rose in altitude from 4300 to 5500 m across the range, as indicated by altitudes of lowest cirque floors and maximum extent of glacial deposits. Highest ELAs occurred on previously unrecognized ice caps that formerly covered extensive highland areas in Tibet north of the range crest. During four distinct Holocene glacial advances of subequal magnitude, ELAs were depressed about 30% as much as the late Pleistocene maximum depression. Depression of ELAs during the late Pleistocene glaciation was about twice as great south of the range crest (950 m) as north of it (400 m). Although the present northward decrease in precipitation causes ELAs to rise northward for 85 km at 7.1 m km-1, the gradient during maximum late Pleistocene glaciation was 11 m km-1. Such a great contrast in glacier response to climate change over a short distance is remarkable and probably reflects increased aridity on the Tibetan Plateau and increased climatic contrast across the Himalayan Range during glacial ages.

Investigating the Language Demands in the Common Core State Standards for English Language Learners: A Comparison Study of Standards

ERIC Educational Resources Information Center

Wolf, Mikyung Kim; Wang, Yuan; Huang, Becky H.; Blood, Ian

2014-01-01

This study reports on a critical review of the language demands contained in the Common Core State Standards for English language arts (CCSS-ELA) with the aim of deriving important implications for the instruction of English language learners. The language demands of the CCSS-ELA were compared with those of existing English language arts (ELA) and…

Response of ELA-A1 horses immunized with lipopeptide containing an equine infectious anemia virus ELA-A1-restricted CTL epitope to virus challenge.

PubMed

Ridgely, Sherritta L; Zhang, Baoshan; McGuire, Travis C

2003-01-17

Lipopeptide containing an ELA-A1-restricted cytotoxic T lymphocyte (CTL) epitope from the envelope surface unit (SU) protein of the EIAV(WSU5) strain was used to immunize three horses having the ELA-A1 haplotype. Peptide-specific ELA-A1-restricted CTL were induced in all three horses, although these were present transiently in PBMC. These horses were further immunized with lipopeptide containing the corresponding CTL epitope from the EIAV(PV) strain. Then, the three immunized horses and three non-immunized horses were challenged by intravenous inoculation with 300 TCID(50) EIAV(PV). All horses developed cell free viremia, fever and thrombocytopenia. However, there was a statistically lower fever and thrombocytopenia severity score in the immunized group. Shorter duration of plasma viral load in two of the three immunized horses likely explains the less severe clinical disease in this group. Results indicate that lipopeptide immunization had a protective effect against development of clinical disease following virus challenge.

"A Respect for the Past, a Knowledge of the Present, and a Concern for the Future": The Role of History in English Education

ERIC Educational Resources Information Center

Thomas, P. L.

2011-01-01

This article argues that ELA teacher candidates and inservice ELA teachers need historical perspectives in their coursework and their practice. Using the life and career of Lou LaBrant, the author examines the value of placing current practice in the context of practice throughout the history of the field of teaching ELA. Patterns examined in…

Resolving a genetic paradox throughout preimplantation genetic diagnosis for autosomal dominant severe congenital neutropenia.

PubMed

Malcov, Mira; Reches, Adi; Ben-Yosef, Dalit; Cohen, Tania; Amit, Ami; Dgany, Orly; Tamary, Hannah; Yaron, Yuval

2010-03-01

Severe congenital neutropenia is an inherited disease characterized by low peripheral blood neutrophils, amenable to bone marrow transplantation. Genetic analysis in the family here described detected a ELA2 splice-site mutation in the affected child and also in his asymptomatic father. The parents requested preimplantation genetic diagnosis (PGD), coupled with HLA matching, to obtain a suitable bone marrow donor for the affected child. A PGD protocol was developed, based on multiplex nested PCR for direct analysis of the ELA2 mutation, flanking polymorphic markers and HLA typing. The amplification efficiency of the mutation was > 90% in single leukocytes from the affected child but only 67% in the father. Analysis of single haploid sperm cells from the father demonstrated three different sperm-cell populations: (1) sperm cells harboring the ELA2 mutation on the 'affected' haplotype, (2) sperm cells without the ELA2 mutation on the 'normal' haplotype, and (3) sperm cells without the ELA2 mutation on the 'affected' haplotype. These data demonstrate that the ELA2 mutation in the father occurred de novo during his embryonic development, resulting in somatic as well as germ-line mosaicism. This conclusion was also taken into consideration when PGD was performed. Copyright (c) 2010 John Wiley & Sons, Ltd.

Early life adversity and inflammation in African Americans and whites in the midlife in the United States survey.

PubMed

Slopen, Natalie; Lewis, Tené T; Gruenewald, Tara L; Mujahid, Mahasin S; Ryff, Carol D; Albert, Michelle A; Williams, David R

2010-09-01

To determine whether early life adversity (ELA) was predictive of inflammatory markers and to determine the consistency of these associations across racial groups. We analyzed data from 177 African Americans and 822 whites aged 35 to 86 years from two preliminary subsamples of the Midlife in the United States biomarker study. ELA was measured via retrospective self-report. We used multivariate linear regression models to examine the associations between ELA and C-reactive protein, interleukin-6, fibrinogen, endothelial leukocyte adhesion molecule-1, and soluble intercellular adhesion molecule-1, independent of age, gender, and medications. We extended race-stratified models to test three potential mechanisms for the observed associations. Significant interactions between ELA and race were observed for all five biomarkers. Models stratified by race revealed that ELA predicted higher levels of log interleukin-6, fibrinogen, endothelial leukocyte adhesion molecule-1, and soluble intercellular adhesion molecule-1 among African Americans (p < .05), but not among whites. Some, but not all, of these associations were attenuated after adjustment for health behaviors and body mass index, adult stressors, and depressive symptoms. ELA was predictive of high concentrations of inflammatory markers at midlife for African Americans, but not whites. This pattern may be explained by an accelerated course of age-related disease development for African Americans.

Enhanced resolution of eosinophilic liver abscess associated with toxocariasis by albendazole treatment.

PubMed

Jang, Eun Young; Choi, Moon Seok; Gwak, Geum Youn; Koh, Kwang Cheol; Paik, Seung Woon; Lee, Joon Hyeok; Paik, Yong Han; Yoo, Byung Chul

2015-04-01

Visceral larva migrans, caused by Toxocara canis and Toxocara cati, has emerged as a significant cause of eosinophilic liver abscess (ELA). Differentiation of ELA associated with toxocariasis (ELA-T) from metastasis or primary liver malignancy is sometimes difficult. However, the role of albendazole treatment remains uncertain in this condition. The aim of this study was to evaluate whether albendazole can enhance the radiologic resolution of ELA-T. We retrospectively reviewed the medical records of the patients diagnosed with ELA-T at our institution between January 2008 and December 2011. ELA-T was diagnosed based on the imaging findings on computed tomography or magnetic resonance imaging and the presence of positive serum IgG antibody for Toxocara canis. Among a total of 163 patients, 32 patients received albendazole (albendazole group) and 131 did not (control group). Baseline characteristics and fate of liver nodules were compared between the two groups. Baseline characteristics (age, sex, number and maximal size of lesions, eosinophil count) were similar between the two groups. Median duration for achieving radiologic resolution in the albendazole group was significantly shorter than in the control group (207 days [range 186-228] vs. 302 days [range 224-380], p=0.023). In Cox regression analysis of the cumulative rates of radiologic resolution, the hazard ratio for albendazole treatment was 1.99 (95% confidence interval, 1.22-3.23). Radiologic resolution of ELA-T can be accelerated with albendazole treatment. Hence, inconvenience associated with long-term follow-up and unnecessary worries among patients can be eliminated with albendazole treatment.

Polymorphism at Expressed DQ and DR Loci in Five Common Equine MHC Haplotypes

PubMed Central

Miller, Donald; Tallmadge, Rebecca L.; Binns, Matthew; Zhu, Baoli; Mohamoud, Yasmin Ali; Ahmed, Ayeda; Brooks, Samantha A.; Antczak, Douglas F.

2016-01-01

The polymorphism of Major Histocompatibility Complex (MHC) class II DQ and DR genes in five common Equine Leukocyte Antigen (ELA) haplotypes was determined through sequencing of mRNA transcripts isolated from lymphocytes of eight ELA homozygous horses. Ten expressed MHC class II genes were detected in horses of the ELA-A3 haplotype carried by the donor horses of the equine Bacterial Artificial Chromosome (BAC) library and the reference genome sequence: four DR genes and six DQ genes. The other four ELA haplotypes contained at least eight expressed polymorphic MHC class II loci. Next Generation Sequencing (NGS) of genomic DNA of these four MHC haplotypes revealed stop codons in the DQA3 gene in the ELA-A2, ELA-A5, and ELA-A9 haplotypes. Few NGS reads were obtained for the other MHC class II genes that were not amplified in these horses. The amino acid sequences across haplotypes contained locus-specific residues, and the locus clusters produced by phylogenetic analysis were well supported. The MHC class II alleles within the five tested haplotypes were largely non-overlapping between haplotypes. The complement of equine MHC class II DQ and DR genes appears to be well conserved between haplotypes, in contrast to the recently described variation in class I gene loci between equine MHC haplotypes. The identification of allelic series of equine MHC class II loci will aid comparative studies of mammalian MHC conservation and evolution and may also help to interpret associations between the equine MHC class II region and diseases of the horse. PMID:27889800

Differences in patient selection and outcomes between SilverHawk atherectomy and laser ablation in the treatment of femoropopliteal in-stent restenosis: a retrospective analysis from a single center.

PubMed

Shammas, Nicolas W; Shammas, Gail A; Jerin, Michael

2013-12-01

To analyze differences in the application and outcomes of SilverHawk atherectomy (SH) and excimer laser ablation (ELA) in the treatment of femoropopliteal in-stent restenosis (ISR) in an unselected cohort of patients treated at a single center. Between January 2005 and June 2010, 81 consecutive patients (46 men; mean age 69.1 years, range 43-86) underwent directional atherectomy (41 SH, 40 ELA) for femoropopliteal ISR lesions. Data were reviewed retrospectively on procedural outcomes, major adverse events, and 1-year target lesion revascularization (TLR) obtained from medical records and supplemented with telephone calls. The primary endpoint was symptom-driven TLR at 1 year; secondary endpoints were death and amputation. ELA was utilized more frequently than SH in longer lesions (210.4±104 vs. 126.2±79.3 mm, respectively; p=0.001), subacute presentation (55% vs. 14.6%, p=0.001), TASC D lesions (47.5% vs. 12.2%), and in patients with more angiographic thrombus (42.5% vs. 4.9%, p=0.001). Final angiographic success (<30% residual narrowing post final treatment) was similar between ELA and SH (92.5% vs. 100%, respectively, p=0.12). Bailout stenting was significantly higher with ELA vs. SH (50.0% vs. 24.4%, p=0.022). At 1 year, TLR had occurred in 48.7% of the ELA patients vs. 31.7% of the SH cases (p=0.171). Regression analysis confirmed that SH was a predictor of TLR at 1 year (hazard ratio 2.679, 95% CI 1.015 to 7.073, p=0.047). Both SH and ELA continue to have a high TLR rate in treating ISR of the femoral and popliteal arteries. A higher rate of delayed failure is seen with SH and an earlier, steeper loss of TLR-free survival is seen with ELA.

Characterization of pancreatic lesions from MT-tgf alpha, Ela-myc and MT-tgf alpha/Ela-myc single and double transgenic mice.

PubMed

Liao, Dezhong Joshua; Wang, Yong; Wu, Jiusheng; Adsay, Nazmi Volkan; Grignon, David; Khanani, Fayyaz; Sarkar, Fazlul H

2006-07-05

In order to identify good animal models for investigating therapeutic and preventive strategies for pancreatic cancer, we analyzed pancreatic lesions from several transgenic models and made a series of novel findings. Female MT-tgf alpha mice of the MT100 line developed pancreatic proliferation, acinar-ductal metaplasia, multilocular cystic neoplasms, ductal adenocarcinomas and prominent fibrosis, while the lesions in males were less severe. MT-tgf alpha-ES transgenic lines of both sexes developed slowly progressing lesions that were similar to what was seen in MT100 males. In both MT100 and MT-tgf alpha-ES lines, TGF alpha transgene was expressed mainly in proliferating ductal cells. Ela-myc transgenic mice with a mixed C57BL/6, SJL and FVB genetic background developed pancreatic tumors at 2-7 months of age, and half of the tumors were ductal adenocarcinomas, similar to what was reported originally by Sandgren et al 1. However, in 20% of the mice, the tumors metastasized to the liver. MT100/Ela-myc and MT-tgf alpha-ES/Ela-myc double transgenic mice developed not only acinar carcinomas and mixed carcinomas as previously reported but also various ductal-originated lesions, including multilocular cystic neoplasms and ductal adenocarcinomas. The double transgenic tumors were more malignant and metastasized to the liver at a higher frequency (33%) compared with the Ela-myc tumors. Sequencing of the coding region of p16ink4, k-ras and Rb cDNA in small numbers of pancreatic tumors did not identify mutations. The short latency for tumor development, the variety of tumor morphology and the liver metastases seen in Ela-myc and MT-tgf alpha/Ela-myc mice make these animals good models for investigating new therapeutic and preventive strategies for pancreatic cancer.

MIDAS - A microcomputer-based image display and analysis system with full Landsat frame processing capabilities

NASA Technical Reports Server (NTRS)

Hofman, L. B.; Erickson, W. K.; Donovan, W. E.

1984-01-01

Image Display and Analysis Systems (MIDAS) developed at NASA/Ames for the analysis of Landsat MSS images is described. The MIDAS computer power and memory, graphics, resource-sharing, expansion and upgrade, environment and maintenance, and software/user-interface requirements are outlined; the implementation hardware (including 32-bit microprocessor, 512K error-correcting RAM, 70 or 140-Mbyte formatted disk drive, 512 x 512 x 24 color frame buffer, and local-area-network transceiver) and applications software (ELAS, CIE, and P-EDITOR) are characterized; and implementation problems, performance data, and costs are examined. Planned improvements in MIDAS hardware and design goals and areas of exploration for MIDAS software are discussed.

Glacier change in the Gangdise Mountains, southern Tibet, since the Little Ice Age

NASA Astrophysics Data System (ADS)

Zhang, Qian; Yi, Chaolu; Fu, Ping; Wu, Yubin; Liu, Jinhua; Wang, Ninglian

2018-04-01

Delineating glacier change during the Little Ice Age (LIA) is of great importance when attempting to understand regional climatic changes and can also help to improve the understanding of any predictions of future glacial changes. However, such knowledge is still lacking for some critical regions of the Tibetan Plateau (TP). In this study, we mapped 4188 contemporary glaciers and reconstructed 1216 LIA areas of glacial coverage in the Gangdise Mountains to the north of the Himalaya using Google Earth satellite imagery. We estimated their paleoglacial areas and equilibrium line altitudes (ELAs) based on the toe-to-headwall altitude ratio (THAR) method. Results show that most glaciers are small (<1 km2), with slope/hanging glaciers the most common (2844 out of 4188 glaciers), while valley glaciers have the greatest coverage (1009.0 km2 out of a total area of 1723.7 km2). Contemporary glaciers have retreated significantly since the LIA, with reductions in length of between 5.5% and 94.7% (mean glacier length 696 m; mean reduction in length 41.7%) and reductions in glacier area of between 4.1% and 94.9% (mean glacier area 0.42 km2; mean reduction in area 44.8%). These reductions have occurred under different local climatic and topographic conditions. The contemporary ELA ranges from 5516 to 6337 m asl; the LIA ELA ranged from 5476 to 6329 m asl. Contemporary and LIA ELA values rise from southeast to northwest. As a general rule, the rise in the ELA value decreases from the eastern to the central Gangdise Mountains and then increases westward, with a mean ELA rise of 45 m. Multiple regression models suggest that 46.8% of the glacier area loss can be explained by glacier elevation, area, and slope. However, only 15.5% of the rise in ELA values can be explained by glacial geometric, topographic, or locational parameters. The spatial pattern of modern ELA values in this region appears inversely related to precipitation, which decreases from southeast to northwest, implying that precipitation is one of the key controls of ELAs. This is also consistent with results from elsewhere in High Asia. In contrast to the Gangdise Mountains' eastern and western sectors, glaciers in the central sector have undergone less change, i.e., in terms of reductions in length, area loss, and rises in ELA. Topography can of course also influence glacial change by creating shielding and/or rainshadow effects and by affecting local temperatures.

Late Pleistocene deglaciation and paleo-environment in the Retezat Mountains, Southern Carpathians

NASA Astrophysics Data System (ADS)

Ruszkiczay-Rüdiger, Zsófia; Madarász, Balázs; Kern, Zoltán; Urdea, Petru; Braucher, Régis; Aster Team

2017-04-01

This study aims to use in situ produced 10Be based Cosmic Ray Exposure (CRE) ages to reconstruct glacier evolution in the Retezat Mts, the Southern Carpathians most glaciated area with peak elevations up to 2509 m asl. In the study area currently devoid of glaciers, the calculated theoretical ELA is at ˜2860 m asl. The paleo-Equilibrium Line Altitudes (ELAs) were calculated over the ˜21 to ˜13 ka time period based on the reconstructed glacial stillstands or re-advances geometries using the ssAAR method [1, 2]. Regarding the Northern side of the Retezat Mts, new and re-evaluated 10Be CRE ages (n=34) [3] were used while regarding the Southern side, they all result from a new sampling (n=25). According to the data, the most extended glaciation occurred during the LGM, down to ˜1050 m asl. on both sides of the Retezat Mts with most probable 10Be CRE ages of 21.0 -1.5+0.8 ka and 20.7 -1.0+0.9 ka. The reconstructed ELA depression in the North was ˜1010 m while it was ˜1190 m, in the South where the valleys glacial system (Lăpuşnicu - Judele) was significantly larger with longer glacier tongues. At the beginning of the Lateglacial (˜17-18 ka) the glaciers withdrew and the North-South difference between the ELA depression was decreased (˜885 m and ˜945 m, respectively). The ELA differences further reduced and vanished for the ˜15.3 ka glacial event - the last cold stage before the abrupt Bölling/Alleröd warming - with ELA depressions of ˜728 m and ˜712 m, respectively. The last glacial phase in the area characterized by small cirque glaciers occurred at 13.5 -0.6+0.6 ka in the North and 13.9 -0.4+0.9 ka in the South. By this time, the ELA depression was reduced to ˜660-680 m. Due to the small glacier size this value may have been influenced by local topoclimatic factors. So far, no data support Younger Dryas or Holocene glaciation of the Retezat Mts. The elevation difference of the ELAs suggests more precipitation on the Southern side of the Retezat Mts during the LGM. This may indicate a southerly wind regime at this part of Europe, which subsequently gave place to the westerly winds during the warming climate of the Lateglacial. Using a Chironomidae-based summer temperature (T) reconstruction from the area [4], T and mean annual precipitation (P) at the ELA were calculated for the ˜15.3 ka stage. Based on Ohmura et al. [5] a ˜4.5-4.9 ˚ C decrease of T and a ˜10-15% increase of P compared to the present values were calculated. Thanks to OTKA PD83610, PD104899; NKM-96/2014, NKM-31/2015; OMAA 90öu17; LP2012-27/2012, INSU/CNRS, the ANR through the program "EQUIPEX Investissement d'Avenir", IRD and CEA. References: [1] Pellitero et al. 2015 Computers & Gerosciences 82: 55-62 [2] Kern and László, 2010. Quat. Sci. Rev. 29, 2781-2787. [3] Ruszkiczay-Rüdiger et al. 2016 Quat. Int. 415. 216-229. [4] Tóth et al., 2012. Quat. Res. 77. 122-131. [5] Ohmura et al. 1992. J. of Glaciology, 38. 397-411.

CSUNSat-1 CubeSat – ELaNa XVII

NASA Image and Video Library

2017-04-04

The primary mission of CSUNSat1 is to space test an innovative low temperature capable energy storage system developed by the Jet Propulsion Laboratory, raising its TRL level to 7 from 4 to 5. The success of this energy storage system will enable future missions, especially those in deep space to do more science while requiring less energy, mass and volume. This CubeSat was designed, built, programmed, and tested by a team of over 70 engineering and computer science students at CSUN.  The primary source of funding for CSUNSat1 comes from NASA’s Smallest Technology Partnership program. Launched by NASA’s CubeSat Launch Initiative on the NET April 18, 2017 ELaNa XVII mission on the seventh Orbital-ATK Cygnus Commercial Resupply Services (OA-7) to the International Space Station and deployed on tbd.

Supporting ELLs before, during, and after Reading

ERIC Educational Resources Information Center

DelliCarpini, Margo

2011-01-01

Working with English language learners in mainstream ELA classrooms can provide rich rewards in terms of developing multiple perspectives, sharing diverse experiences, and developing understanding of different cultural practices. However, these students can also challenge mainstream teachers. Supporting ELLs throughout the reading process can…

ptf1a+ , ela3l- cells are developmentally maintained progenitors for exocrine regeneration following extreme loss of acinar cells in zebrafish larvae.

PubMed

Schmitner, Nicole; Kohno, Kenji; Meyer, Dirk

2017-03-01

The exocrine pancreas displays a significant capacity for regeneration and renewal. In humans and mammalian model systems, the partial loss of exocrine tissue, such as after acute pancreatitis or partial pancreatectomy induces rapid recovery via expansion of surviving acinar cells. In mouse it was further found that an almost complete removal of acinar cells initiates regeneration from a currently not well-defined progenitor pool. Here, we used the zebrafish as an alternative model to study cellular mechanisms of exocrine regeneration following an almost complete removal of acinar cells. We introduced and validated two novel transgenic approaches for genetically encoded conditional cell ablation in the zebrafish, either by caspase-8-induced apoptosis or by rendering cells sensitive to diphtheria toxin. By using the ela3l promoter for exocrine-specific expression, we show that both approaches allowed cell-type-specific removal of >95% of acinar tissue in larval and adult zebrafish without causing any signs of unspecific side effects. We find that zebrafish larvae are able to recover from a virtually complete acinar tissue ablation within 2 weeks. Using short-term lineage-tracing experiments and EdU incorporation assays, we exclude duct-associated Notch-responsive cells as the source of regeneration. Rather, a rare population of slowly dividing ela3l- negative cells expressing ptf1a and CPA was identified as the origin of the newly forming exocrine cells. Cells are actively maintained, as revealed by a constant number of these cells at different larval stages and after repeated cell ablation. These cells establish ela3l expression about 4-6 days after ablation without signs of increased proliferation in between. With onset of ela3l expression, cells initiate rapid proliferation, leading to fast expansion of the ela3l -positive population. Finally, we show that this proliferation is blocked by overexpression of the Wnt-signaling antagonist dkk1b In conclusion, we show a conserved requirement for Wnt signaling in exocrine tissue expansion and reveal a potential novel progenitor or stem cell population as a source for exocrine neogenesis after complete loss of acinar cells. © 2017. Published by The Company of Biologists Ltd.

A comparison of buffered lidocaine versus ELA-Max before peripheral intravenous catheter insertions in children.

PubMed

Luhmann, Janet; Hurt, Sarah; Shootman, Mario; Kennedy, Robert

2004-03-01

Peripheral intravenous catheter (PIV) insertion is a common, painful experience for many children in the pediatric emergency department. Although local anesthetics such as injected buffered lidocaine have been shown to be effective at reducing pain and anxiety associated with PIV insertion, they are not routinely used. ELA-Max, a topical local anesthetic, has the advantage of needle-free administration but has not been compared with buffered lidocaine for PIV insertion. To compare the reduction of pain and anxiety during PIV insertion provided by subcutaneous buffered 1% lidocaine or topical ELA-Max in children. A randomized trial in children 4 to 17 years old undergoing PIV insertion with 22-gauge catheters was conducted. Children received either buffered lidocaine or ELA-Max. Buffered lidocaine was administered by using 30-gauge needles to inject 0.1 to 0.2 mL subcutaneously just before PIV insertion. ELA-Max was applied to the skin and occluded with Tegaderm 30 minutes before PIV insertion. Self-reported Visual Analog Scale (VAS) questionnaires (rating on a scale of 1-10; 1 = no pain, anxiety) were completed by patients and their parents before PIV insertion to assess baseline perceptions about pain and anxiety associated with PIV insertion and immediately after PIV insertion to assess pain and anxiety associated with the experience. After PIV insertion, the nurse who inserted the PIV also completed a VAS questionnaire assessing technical difficulty and satisfaction with the local anesthesia. A blinded observer also completed a VAS questionnaire to assess pain and anxiety associated with the PIV insertion. Data were analyzed by using chi2 and t tests. Sixty-nine subjects were enrolled, and questionnaires were competed by all (mean age: 12.1 +/- 4.5 years; 61% female). There were no differences for buffered lidocaine and ELA-Max groups in age, gender, race, prior IV experience, or baseline pain and anxiety. There were no significant differences between buffered lidocaine and ELA-Max in mean pain and anxiety after PIV insertion by patient, parent, and blinded observer ratings. Nurse ratings of technical difficulty, number of PIV-insertion attempts, and satisfaction with local anesthesia also were not significantly different for buffered lidocaine and ELA-Max groups. ELA-Max provided similar pain and anxiety reduction during PIV insertion in children compared with injected buffered lidocaine. Technical difficulty and satisfaction by nurses inserting the PIV also were similar.

Menstrual Cycle Hormone Changes in Women Traversing Menopause: Study of Women’s Health Across the Nation

PubMed Central

Crawford, Sybil L.; El Khoudary, Samar R.; Allshouse, Amanda A.; Burnett-Bowie, Sherri-Ann; Finkelstein, Joel; Derby, Carol; Matthews, Karen; Kravitz, Howard M.; Harlow, Sioban D.; Greendale, Gail A.; Gold, Ellen B.; Kazlauskaite, Rasa; McConnell, Dan; Neal-Perry, Genevieve; Pavlovic, Jelena; Randolph, John; Weiss, Gerson; Chen, Hsiang-Yu; Lasley, Bill

2017-01-01

Context: Menstrual cycle hormone patterns in women approaching menopause are inadequately studied. Objective: To describe day-to-day menstrual cycle hormones in women as they approach menopause from the Study of Women's Health Across the Nation Daily Hormone Study (DHS). Design: DHS enrollees collected daily urine for one entire menstrual cycle or up to 50 days, whichever came first, annually, up to the final menstrual period (FMP) or for up to 10 years. Setting: Seven sites across the United States. Participants: A total of 511 premenopausal or early perimenopausal women at enrollment, within 10 years before menopause. Intervention: Time-to-FMP measurement. Main Outcome Measures: Evidence of luteal activity (ELA), determined using objective algorithms. Menstrual cycle/segment length; whole cycle, and segment integrated urinary luteinizing hormone, follicle-stimulating hormone, estrone conjugates, and pregnanediol glucuronide (Pdg) for each year, organized around the FMP. Results: Mean menstrual cycle length was remarkably preserved at 26 to 27 days in ELA cycles; non-ELA cycles had greater variability. The percentage of cycles that were ELA remained high until 5 years before the FMP (87.9%); only 22.8% of cycles within 1 year of the FMP were ELA. Whole cycle hormones remained relatively stable up to 3 years before the FMP, when gonadotropins began to increase. Pdg excretion declined slowly with progress to the FMP, but Pdg patterns of ELA cycles remained distinguishable from non-ELA. Conclusions: Menstrual cycle hormone patterns in perimenopausal women resemble those of midreproductive-aged women until 5 years before menopause, and presumably ovulatory cycles retain a potentially fertile pattern up to the end of reproductive life. PMID:28368525

A randomized, double-blind comparison study of EMLA and ELA-Max for topical anesthesia in children undergoing intravenous insertion.

PubMed

Koh, Jeffrey L; Harrison, Dale; Myers, Robert; Dembinski, Robert; Turner, Helen; McGraw, Terrence

2004-12-01

Topical anesthetics may help reduce discomfort associated with procedures involving needle-puncture, such as intravenous (i.v.) insertions, in children. EMLA cream has become a common, noninvasive therapy for topical anesthesia in children. ELA-Max is a recently introduced topical anesthetic cream marketed as being as effective in producing topical anesthesia after a 30-min application as EMLA is after a 60-min application. The purpose of this research was to compare ELA-Max at 30 min with EMLA at 60 min for providing topical anesthesia for i.v. insertions in children. Sixty children, ages 8-17 years, requiring an i.v. were randomized to receive either the 30 min application of ELA-Max (n = 30) or the 60 min application of EMLA (n = 30). Children rated any pain associated with the i.v. insertion using a 100-mm Visual Analog Scale (VAS). The anesthesiologist assessed the presence of blanching at the site and rated the difficulty of placing the i.v. There was no clinically or statistically significant difference in pain ratings (P = 0.87) between the ELA-Max (mean = 25.7) and the EMLA (mean = 26.8) groups. ELA-Max caused significantly (P = 0.04) less blanching than EMLA, however there was no difference in the anesthesiologists' rating of the difficulty of the i.v. placement between the groups (P = 0.73). Results from this study support the claim that a 30-min application of ELA-Max (with occlusion) is as effective as a 60-min application of EMLA (with occlusion) for producing topical anesthesia for i.v. insertion in children.

Mutations in the ELA2 gene encoding neutrophil elastase are present in most patients with sporadic severe congenital neutropenia but only in some patients with the familial form of the disease.

PubMed

Ancliff, P J; Gale, R E; Liesner, R; Hann, I M; Linch, D C

2001-11-01

Severe congenital neutropenia (SCN) was originally described as an autosomal recessive disorder. Subsequently, autosomal dominant and sporadic forms of the disease have been recognized. All forms are manifest by persistent severe neutropenia and recurrent bacterial infection. In contrast, cyclical hematopoiesis is characterized by periodic neutropenia inter-spaced with (near) normal neutrophil counts. Recently, linkage analysis on 13 affected pedigrees identified chromosome 19p13.3 as the likely position for mutations in cyclical hematopoiesis. Heterozygous mutations in the ELA2 gene encoding neutrophil elastase were detected in all families studied. Further work also demonstrated mutations in ELA2 in sporadic and autosomal dominant SCN. However, all mutations described to date are heterozygous and thus appear to act in a dominant fashion, which is inconsistent with an autosomal recessive disease. Therefore, the current study investigated whether mutations in ELA2 could account for the disease phenotype in classical autosomal recessive SCN and in the sporadic and autosomal dominant types. All 5 exons of ELA2 and their flanking introns were studied in 18 patients (3 autosomal recessive, 5 autosomal dominant [from 3 kindreds], and 10 sporadic) using direct automated sequencing. No mutations were found in the autosomal recessive families. A point mutation was identified in 1 of 3 autosomal dominant families, and a base substitution was identified in 8 of 10 patients with the sporadic form, though 1 was subsequently shown to be a low-frequency polymorphism. These results suggest that mutations in ELA2 are not responsible for classical autosomal recessive Kostmann syndrome but provide further evidence for the role of ELA2 in SCN.

Associations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness.

PubMed

Gouin, J P; Zhou, Q Q; Booij, L; Boivin, M; Côté, S M; Hébert, M; Ouellet-Morin, I; Szyf, M; Tremblay, R E; Turecki, G; Vitaro, F

2017-08-07

Recent models propose deoxyribonucleic acid methylation of key neuro-regulatory genes as a molecular mechanism underlying the increased risk of mental disorder associated with early life adversity (ELA). The goal of this study was to examine the association of ELA with oxytocin receptor gene (OXTR) methylation among young adults. Drawing from a 21-year longitudinal cohort, we compared adulthood OXTR methylation frequency of 46 adults (23 males and 23 females) selected for high or low ELA exposure based on childhood socioeconomic status and exposure to physical and sexual abuse during childhood and adolescence. Associations between OXTR methylation and teacher-rated childhood trajectories of anxiousness were also assessed. ELA exposure was associated with one significant CpG site in the first intron among females, but not among males. Similarly, childhood trajectories of anxiousness were related to one significant CpG site within the promoter region among females, but not among males. This study suggests that females might be more sensitive to the impact of ELA on OXTR methylation than males.

"Winsight"™ Assessment System: Preliminary Theory of Action. Research Report. ETS RR-17-26

ERIC Educational Resources Information Center

Wylie, E. Caroline

2017-01-01

The "Winsight"™Assessment System integrates summative, interim (including both benchmark assessments and testlets), and formative assessment components initially focused on mathematics and English language arts (ELA) in Grades 3-8 and high school.This report provides a preliminary theory of action for the Winsight Assessment System. A…

Reconstruction of late Holocene glacier retreat and relevant climatic and topographic patterns in southeastern Tibet by glacier mapping and equilibrium line altitude calculation

NASA Astrophysics Data System (ADS)

Loibl, David; Lehmkuhl, Frank

2014-05-01

Temperate glaciers in the eastern Nyainqêntanglha range, southeastern Tibet, are highly sensitive to climate change and are therefore of particular high interest for research on late Holocene changes of the monsoonal climate in High Asia. However, due to the remoteness of the area, the scarcity of empirical data, and the challenges to remote sensing work posed by cloud and snow cover, knowledge about the glacier dynamics and changes is still very limited. We applied a remote sensing approach that allowed a comprehensive regional glacier survey despite the few available data. Geomorphologic characteristics, distribution and late Holocene changes of 1964 glaciers were mapped from one of the few appropriate late summer satellite images: a Landsat ETM+ scene from September 23, 1999. The glacier dataset was subsequently parameterized by DEM supported measurements. Complex climate-relief-glacier interactions were studied in detail for three large glaciers in neighboring valleys. Despite their spatial proximity, these display strong heterogeneity in terms of catchment morphology, debris cover, and glacier characteristics. The results of this case study then provided the conceptual basis to use geomorphological evidence, i.e. trimlines and latero-frontal moraines, to obtain quantitative data on the changes since the Little Ice Age (LIA) maximum glacier advance. Statistical analysis of glacier length change revealed an average retreat of ~ 40 % and a trend towards stronger retreat for smaller glaciers. An evaluation of different methods to calculate equilibrium line altitudes (ELAs) indicates that an optimized toe-to-ridge altitude method (TRAM) outperforms other methods in settings with complex topography and a lack of mass-balance measurements. However, a large number of glacier measurements is crucial for high quality TRAM results and special attention has to be paid to different morphological glacier characteristics: debris-cover, reconstitution, valley floor limitation, and detachment of glacier tributaries, are criteria that prevent reliable ELA calculations. In order to determine the best-fitting TRAM ratio value and to test the quality of the calculated ELAs, a remote sensing approach was applied: the altitudes of transient snowlines visible in the late summer Landsat scene were measured from the DEM and compared to TRAM results for each glacier. The interpolated ELA results show a southeast-northwest gradient ranging from 4,400 to 5,600 m a.s.l. and an average ELA rise of ~ 98 m since the LIA. Due to the large amount of measurements, the ELA distribution reveals topographic effects down to the catchment scale, i.e. orographic rainfalls and leeward shielding. Contrasting to the expectations for subtropical settings, glaciers on south facing slopes have not retreated strongest and ELAs on south facing slopes did not rise furthest. Instead, highly heterogeneous spatial patterns emerge that show a strong imprint of both, topography and monsoonal dynamics. The interpretation of these patterns provides insights into the monsoonal system and the characteristics of late Holocene glacier change in southeastern Tibet. For example, the ELA distribution reveals that the study area is influenced by both, Indian summer monsoon and East Asian summer monsoon, but that the latter does not reach the Tibetan Plateau.

Expression of human cationic trypsinogen (PRSS1) in murine acinar cells promotes pancreatitis and apoptotic cell death

PubMed Central

Athwal, T; Huang, W; Mukherjee, R; Latawiec, D; Chvanov, M; Clarke, R; Smith, K; Campbell, F; Merriman, C; Criddle, D; Sutton, R; Neoptolemos, J; Vlatković, N

2014-01-01

Hereditary pancreatitis (HP) is an autosomal dominant disease that displays the features of both acute and chronic pancreatitis. Mutations in human cationic trypsinogen (PRSS1) are associated with HP and have provided some insight into the pathogenesis of pancreatitis, but mechanisms responsible for the initiation of pancreatitis have not been elucidated and the role of apoptosis and necrosis has been much debated. However, it has been generally accepted that trypsinogen, prematurely activated within the pancreatic acinar cell, has a major role in the initiation process. Functional studies of HP have been limited by the absence of an experimental system that authentically mimics disease development. We therefore developed a novel transgenic murine model system using wild-type (WT) human PRSS1 or two HP-associated mutants (R122H and N29I) to determine whether expression of human cationic trypsinogen in murine acinar cells promotes pancreatitis. The rat elastase promoter was used to target transgene expression to pancreatic acinar cells in three transgenic strains that were generated: Tg(Ela-PRSS1)NV, Tg(Ela-PRSS1*R122H)NV and Tg(Ela-PRSS1*N29I)NV. Mice were analysed histologically, immunohistochemically and biochemically. We found that transgene expression is restricted to pancreatic acinar cells and transgenic PRSS1 proteins are targeted to the pancreatic secretory pathway. Animals from all transgenic strains developed pancreatitis characterised by acinar cell vacuolisation, inflammatory infiltrates and fibrosis. Transgenic animals also developed more severe pancreatitis upon treatment with low-dose cerulein than controls, displaying significantly higher scores for oedema, inflammation and overall histopathology. Expression of PRSS1, WT or mutant, in acinar cells increased apoptosis in pancreatic tissues and isolated acinar cells. Moreover, studies of isolated acinar cells demonstrated that transgene expression promotes apoptosis rather than necrosis. We therefore conclude that expression of WT or mutant human PRSS1 in murine acinar cells induces apoptosis and is sufficient to promote spontaneous pancreatitis, which is enhanced in response to cellular insult. PMID:24722290

Ela2 mutations and clinical manifestations in familial congenital neutropenia.

PubMed

Shiohara, Masaaki; Shigemura, Tomonari; Saito, Shoji; Tanaka, Miyuki; Yanagisawa, Ryu; Sakashita, Kazuo; Asada, Hiroshi; Ishii, Eizaburo; Koike, Kazutoshi; Chin, Motoaki; Kobayashi, Masao; Koike, Kenichi

2009-05-01

Three familial cases of each of severe congenital neutropenia (SCN) and cyclic neutropenia (CN) in addition to 3 sporadic cases of SCN were analyzed for neutrophil elastase (Ela2) gene mutation. The contents of the neutrophil-specific granule proteins cathelicidin antimicrobial peptide and neutrophil gelatinase-associated lipocalin were also analyzed in SCN. Genomic DNA was extracted from the patients' peripheral blood or bone marrow, and the coding sequence of the Ela2 gene was amplified by polymerase chain reaction and subjected to direct sequencing. The contents of antimicrobial peptides were analyzed by flow cytometry. Three cases of familial SCN (P13L, R52P, and S97L), 2 of familial CN (W212stop and P110L), and 1 of sporadic SCN (V72M) were shown to have heterozygous mutations in the Ela2 gene. W212stop found in a familial CN case was a novel mutation of Ela2. Prophylactic treatment for growth factors or antibiotic prophylaxis against bacterial infection was useful for lowering the frequency of infectious episodes. Adult patients tended to have less frequent infections compared with minors in the same family. The contents of both cathelicidin antimicrobial peptide and neutrophil gelatinase-associated lipocalin were significantly reduced in SCN compared with healthy controls. Prophylaxis by growth factor or antibiotics is useful for decreasing risks of bacterial infections in SCN and CN. Adults were likely to have less frequent infections than children in familial cases of SCN and CN with the same mutation of Ela2.

Low molecular weight heparin may benefit nephrotic remission in steroid‑sensitive nephrotic syndrome via inhibiting elastase.

PubMed

Zhai, Songhui; Hu, Lijuan; Zhong, Lin; Tao, Yuhong; Wang, Zheng

2017-12-01

Low molecular weight heparin (LMWH) has a structure similar to heparan sulfate, which exerts anti‑inflammatory effects via inhibiting elastase (Ela) activity. Release of Ela along the glomerular capillary wall may induce glomerular injury and proteinuria. The present study aimed to investigate the influence of LMWH on steroid‑sensitive nephrotic syndrome (SSNS) and the potential underlying mechanism. A total of 40 SSNS patients and 20 healthy controls were recruited. SSNS patients were treated with LMWH and prednisone simultaneously (LMWH+pred group) or with prednisone alone (pred group). Proteinuria, urinary glycosaminoglycans (GAGs), serum Ela and urinary creatinine levels were measured. The nephrotic period of SSNS was 15.93±5.78 days. The nephrotic period of SSNS in LMWH+pred group was significantly reduced compared with the pred group (14.13±4.56 vs. 18.63±6.49 days; P<0.05). At the follow‑up of the SSNS patients, there was no statistically significant difference in number of relapses between the LMWH+pred and pred groups. Proteinuria (2.51±0.97 g/24 h), urinary GAG levels (4.92±0.87 mg/mmol creatinine) and serum Ela levels (77.64±10.99 ng/l) were significantly greater in the nephrotic period of SSNS compared with the remission period (0.107±0.026 g/24 h, 1.53±0.27 mg/mmol Cr and 41.92±7.81 ng/l, respectively) and the healthy control group (0.098±0.027 g/24 h, 1.40±0.26 mg/mmol creatinine and 38.43±9.83 ng/l, respectively; P<0.05). During the remission period, urinary GAG and serum Ela levels in the LMWH+pred group were significantly reduced compared with the pred group (P<0.05), whereas proteinuria did not differ between these groups (P>0.05). Positive correlations were revealed between urinary GAG excretion and proteinuria (r=0.877; P<0.05), proteinuria and serum Ela levels (r=0.844; P<0.05) and serum Ela levels and urinary GAG excretion (r=0.881; P<0.05). The results of the present study indicated that elevated serum Ela levels may induce proteinuria by degrading GAGs in the glomerular basement membrane in children with SSNS. LMWH may benefit nephrotic remission of SSNS via inhibiting Ela.

Extensive Quaternary glaciations in eastern Turkey

NASA Astrophysics Data System (ADS)

Yeşilyurt, Serdar; Akçar, Naki; Doǧan, Uǧur; Yavuz, Vural; Ivy-Ochs, Susan; Vockenhuber, Christof; Schlunegger, Fritz; Schlüchter, Christian

2016-04-01

During cold periods in the Quaternary, global ice volume increased and as a result valley glaciers advanced and the vice versa occurred during the warm periods. Quaternary glacier fluctuations had been also recorded in the Turkish mountains. Recently, the chronology of Late Quaternary advances in the northern and western Turkish mountains was reconstructed by surface exposure dating. However, these advances in the eastern Turkey are not dated yet. In this study, we investigated paleoglaciations in Kavuşşahap Mountains, which is located to the south of Lake Van in eastern Turkey. These mountains are one of the extensively glaciated areas in Turkey. Glacial activity is evidenced by more than 20 U-shaped valleys. For instance, one of the prominent and well-preserved glacial landscapes of Turkey is situated in the Narlıca valley system. Lateral and terminal moraines in the valley system indicate more than 10 glacial advances. To build their chronology, 39 erratic carbonaceous boulders were sampled for surface exposure dating with cosmogenic 36Cl. We also reconstructed the ice margin reconstruction of the Narlıca paleoglacier using the accumulation area ratio and area-altitude balance ratio approaches. We estimated an equilibrium line altitude (ELA) of ca. 2900 m above sea level based on the maximum ice extend, which implied ca. 800 m decrease in the ELA during the Late Quaternary in comparison to the lower bound of the modern ELA estimate. The first results of the surface exposure dating will be presented.

A high-fat diet activates oncogenic Kras and COX2 to induce development of pancreatic ductal adenocarcinoma in mice.

PubMed

Philip, Bincy; Roland, Christina L; Daniluk, Jaroslaw; Liu, Yan; Chatterjee, Deyali; Gomez, Sobeyda B; Ji, Baoan; Huang, Haojie; Wang, Huamin; Fleming, Jason B; Logsdon, Craig D; Cruz-Monserrate, Zobeida

2013-12-01

Obesity is a risk factor for pancreatic ductal adenocarcinoma (PDAC), but it is not clear how obesity contributes to pancreatic carcinogenesis. The oncogenic form of KRAS is expressed during early stages of PDAC development and is detected in almost all of these tumors. However, there is evidence that mutant KRAS requires an additional stimulus to activate its full oncogenic activity and that this stimulus involves the inflammatory response. We investigated whether the inflammation induced by a high-fat diet, and the accompanying up-regulation of cyclooxygenase-2 (COX2), increases Kras activity during pancreatic carcinogenesis in mice. We studied mice with acinar cell-specific expression of KrasG12D (LSL-Kras/Ela-CreERT mice) alone or crossed with COX2 conditional knockout mice (COXKO/LSL-Kras/Ela-CreERT). We also studied LSL-Kras/PDX1-Cre mice. All mice were fed isocaloric diets with different amounts of fat, and a COX2 inhibitor was administered to some LSL-Kras/Ela-CreERT mice. Pancreata were collected from mice and analyzed for Kras activity, levels of phosphorylated extracellular-regulated kinase, inflammation, fibrosis, pancreatic intraepithelial neoplasia (PanIN), and PDACs. Pancreatic tissues from LSL-Kras/Ela-CreERT mice fed high-fat diets (HFDs) had increased Kras activity, fibrotic stroma, and numbers of PanINs and PDACs than LSL-Kras/Ela-CreERT mice fed control diets; the mice fed the HFDs also had shorter survival times than mice fed control diets. Administration of a COX2 inhibitor to LSL-Kras/Ela-CreERT mice prevented these effects of HFDs. We also observed a significant reduction in survival times of mice fed HFDs. COXKO/LSL-Kras/Ela-CreERT mice fed HFDs had no evidence for increased numbers of PanIN lesions, inflammation, or fibrosis, as opposed to the increases observed in LSL-Kras/Ela-CreERT mice fed HFDs. In mice, an HFD can activate oncogenic Kras via COX2, leading to pancreatic inflammation and fibrosis and development of PanINs and PDAC. This mechanism might be involved in the association between risk for PDAC and HFDs. Copyright © 2013 AGA Institute. Published by Elsevier Inc. All rights reserved.

Reconstruction of Equilibrium Line Altitudes of Nevado Coropuna Glaciers (Southern Peru) from the Late Pleistocene to the present

NASA Astrophysics Data System (ADS)

Úbeda, J.; Palacios, D.; Vázquez, L.

2009-04-01

The Nevado Coropuna (15°31'S-72°39'W) is a volcanic complex located 200 km NE of the city of Arequipa, in the Southern Peruvian Andes. The summit area in the complex is covered with a glacier system formed by dozens of branches descending in all directions totaling many km2 in surface area. The study of the volcanic complex and its glaciers is of great interest because it is the main water reserve for tens of thousands of people, because of the risk scenario created by the presence of ice masses on a volcano with relatively recent activity, and because it constitutes an excellent geoindicator of the effects of climate change on ice masses in the western mountain chain of the Central Andes. This research aims to analyze glacier evolution using as geoindicators variations in glacier surface and equilibrium line altitudes (ELAs), defining deglaciation rates based on those variations and preparing forecasts with them on when the ice masses might disappear if the same rates were to occur in the future. In addition, a first estimation is attempted of the chronologies of the last phase of volcanic activity and the last phase of maximum glacier advance that can be attributed to the Late Glacial or Last Glacial Maximum periods. To achieve these aims, digital topography with 50m contour interval, two orthophotos of the central section of the Coropuna complex (15-6-1955 and 21-10-1986), an ASTER satellite image (12-11-2007) and geomorphological mapping of the volcanic complex created in a previous phase of the research (Ubeda, 2007) were integrated into a Geographical Information System (GIS). The GIS was used to determine the global extent of the glacier system, and in more detail, that of two groups (NE and SE) in 1955, 1986 and 2007. Using the geomorphological cartography as a basis, the extent of the glaciers during their last advance in the Little Ice Age (LIA) and their last maximum advance were calculated. Next, surface areas for all phases were calculated using automatic functions within the GIS operating environment. To reconstruct the ELAs of the glaciers, the Area x Altitude Balance Ratio (AABR) method was used. This method is extensively described in Osmaston (2005). To determine the rates of deglaciation, variations observed for 2007 in surface areas and ELAs against their values in 1986, 1955 and the Little Ice Age (LIA) were used as geoindicators. Establishing deglaciation rates has allowed forecasts to be made as to when the complete disappearance of ice mass could occur for three future scenarios, considering the hypothetical reproduction in each scenario of the rates of deglaciation observed since 1986 (Scenario 1), 1955 (Scenario 2) and the LIA (Scenario 3). To determine the chronology of the last maximum advance of the glaciers and the last volcanic manifestations, samples were taken from moraine blocks and glaciated rocky thresholds, and also from lava ejected during the last eruption, in the eastern sector of the complex. Due to their recent external appearance, since they have been channeled by glacial valleys and have been affected by ice masses only at the head, these lavas had been dated as Holocene. Absolute dating was performed using cosmogenic methods (Cl36). As a result of applying the proposed method, glacial system surface areas have been estimated for 2007 (47 km2), 1986 (54 km2) and 1955 (56 km2), implying a reduction of ~18% in 52 years. The process appears to have speeded up in the last decades (~13% in only 21 years). Surfaces were also estimated and ELAs reconstructed for the NE and SE groups in 2007, 1986, 1955, the Little Ice Age and during the last maximum advance. Glaciers from the NE group show an area during all periods (2.3, 2.7, 2.9, 3.3 and 30 km2) smaller than SE group glaciers (8.1, 9.9, 10.3, 11.9 and 66.5 km2). An individual analysis of glaciers in the NE and SE groups in 2007 shows a reduction in surface area two to four times greater than that observed between 1955 and 1986. ELAs are also higher for all periods in the Northern section (5968, 5930, 5923, 5886 and 5186 m) than in the Southern section (5862, 5806, 5787 and 4951 m). The depression in ELAs during the LIA was similar in the NE (~82 m) and in the SE (~86 m). However, the 2007 ELA shows a depression of 106 m in the Southern direction. The magnitude of this depression has shown a marked tendency towards reduction in recent decades (136 m in 1955 and 124 m in 1986). Furthermore, the decrease in ELA depression seems to occur faster, with ↓Z ~12 m between 1955 and 1986 and ↓Z ~18 m between 1986 and 2007. However, during the Little Ice Age (~110 m) that value was closer to the current value (106 m). Depression in ELAs during the last maximum glacier advance has been estimated at ~782 m (NE) and ~847 m (SE). During that period, the N-S depression reached a maximum value of 235 m. These results agree with those obtained for the eastern range of the Central Andes (Smith et al. 2005 a and b) and are also within the depression intervals and trends proposed in regional-scale studies (Kelin et al. 1999). Analyses performed on a sample from a block situated on a lateral moraine in the Queñua Ranra Quebrada (NE group of the complex) suggest a chronology of ~17 Cl36 ky. for the last maximum ice mass advance. This date is in agreement with the depression in SST temperature during the same period, deduced from analyzing Mg/Ca ratios in marine foraminifera shells from the Galapagos Islands (Lea, 2006). Using surfaces and ELAs as geoindicators, deglaciation rates and the Horizon without glaciers (H0) have been calculated globally, for the complete glacier system in scenarios 1 and 2, and for glaciers in the pilot group in scenarios 1, 2 and 3. Results show that the deglaciation process is occurring differentially. Whereas several masses could disappear in a few decades, others could be preserved for centuries. Regarding the last phase of volcanic activity, a lava sample has been dated at only ~2 Cl36 ky. Testing the proposed method has allowed the modeling of glacier evolution using variations observed in surfaces and ELAs as geoindicators. Results from the global-scale analysis are only a preliminary approximation to the problem. Detailed analysis of the glaciers in the NE and SE groups has yielded more precise results. Forecasts about future glacier retreat, interest in finding out about their past evolution and the absolute chronology of the last phase of volcanic activity, which confirms their recent character, suggest the need to extend our understanding of the evolution of the Nevado Coropuna's volcanic complex and glacier system. References Klein, A.G., Seltzer, G.O. & Isacks, B.L., 1999. Modern and Local Last Glacial Maximum snowlines in the Central Andes of Peru, Bolivia and Northern Chile. Quaternary Research Reviews, 18: 3-84. Lea, D.W., D.K. Pak, C.L. Belanger, H.J. Spero, M.A. Hall, and N.J. Shackleton, 2006. Galapagos paleoclimate history of surface waters over the last 135,000 yr. Quaternary Science Reviews, 25 (11-12): 1152-1167. Osmaston, H., 2005. Estimates of glacier equilibrium line altitudes by the Area x Altitude, the Area x Altitude Balance Ratio and the Area x Altitude Balance Index methods and their validation. Quaternary International, 22-31: 138-139. Smith, J., Seltzer, G.O., Rodbellb, D.T. & Klein, A.G., 2005 a. Regional synthesis of last glacial maximum snowlines in the tropical Andes, South America. Quaternary International, 138-139:145-167. Smith, JA, Seltzer, GO, Farber, DL, Rodbell, DT & Finkel, R.C., 2005 b. Early Local Last Glacial Maximum in the Tropical Andes. Science, 308. Ubeda, J., 2007. Geomorphological characterization of the northern sector of the Central Volcanic Zone of the Central Andes. Approach to a case study: the glacier of the volcano Nevado Coropuna complex. Research work to obtain the Diploma of Advanced Studies, Universidad Complutense de Madrid, Madrid, 312 pp.

Development and evaluation of an enzyme-labeled antibody test for the rapid detection of hog cholera antibodies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Saunders, G.C.

1977-01-01

A rapid enzyme-labeled antibody (ELA) microtechnique for the screening of swine for hog cholera antibodies was developed and evaluated with a blind study, using a 640-sample hog cholera serum bank. The total time to run a group of 22 samples was approximately 1 hour. The ELA test results correlated >99% with hog cholera serum-neutralization test results on the same serums. Test results also indicated that the ELA test shares with the hog cholera serum-neutralization test the problem of cross reactions between the antibodies of hog cholera and bovine viral diarrhea.

CAPE-2 Cubesat - ELaNa IV

NASA Image and Video Library

2016-07-25

CAPE-2: Cajun Advanced Picosatellite Experiment – ELaNa IV CAPE-2 was developed by students from the University of Louisiana Lafayette to engage, inspire and educate K-12 students to encourage them to pursue STEM careers. The secondary focus is the technology demonstration of deployed solar panels to support the following payloads: text to speech, voice repeater, tweeting, email, file transfer and data collection from buoys. Launched by NASA’s CubeSat Launch Initiative on the ELaNa IV mission as an auxiliary payload aboard the U.S. Air Force-led Operationally Responsive Space (ORS-3) Mission on November 19, 2013.

A situation-specific approach to measure attention in adults with ADHD: The everyday life attention scale (ELAS).

PubMed

Groen, Yvonne; Fuermaier, Anselm B M; Tucha, Lara; Weisbrod, Matthias; Aschenbrenner, Steffen; Tucha, Oliver

2018-03-14

This study describes the development and utility of a new self-report measure of attentional capacities of adults with Attention Deficit Hyperactivity Disorder (ADHD): the Everyday Life Attention Scale (ELAS). Different from previous attention scales, attentional capacities are rated for nine everyday situations. Study 1 investigated the factor structure, validity, and reliability of the ELAS in 1206 healthy participants. Confirmatory factor analysis supported a situation-specific approach which categorizes everyday attention into nine situation scales: Reading, Movie, Activity, Lecture, Conversation, Assignment, Cooking, Cleaning up, and Driving. Each scale was composed of ratings for sustained, focused, selective, and divided attention as well as motivation, and had good internal consistency. Most scales showed weak correlations with ADHD Symptoms, Executive Functioning, and Memory Efficacy. Study 2 further investigated the sensitivity of the ELAS in 80 adults with ADHD compared to matched healthy controls and a mixed clinical group of 56 patients diagnosed with other psychiatric disorders. Compared to healthy controls, patients with ADHD reported reduced attentional capacities with large effect sizes on all situation scales and had a substantially higher number of situations with impaired attention scores. The ELAS may become useful in the clinical evaluation of ADHD and related psychiatric disorders in adults.

Polar Ice Caps: a Canary for the Greenland Ice Sheet

NASA Astrophysics Data System (ADS)

Honsaker, W.; Lowell, T. V.; Sagredo, E.; Kelly, M. A.; Hall, B. L.

2010-12-01

Ice caps are glacier masses that are highly sensitive to climate change. Because of their hypsometry they can have a binary state. When relatively slight changes in the equilibrium line altitude (ELA) either intersect or rise above the land the ice can become established or disappear. Thus these upland ice masses have a fast response time. Here we consider a way to extract the ELA signal from independent ice caps adjacent to the Greenland Ice Sheet margin. It may be that these ice caps are sensitive trackers of climate change that also impact the ice sheet margin. One example is the Istorvet Ice Cap located in Liverpool Land, East Greenland (70.881°N, 22.156°W). The ice cap topography and the underlying bedrock surface dips to the north, with peak elevation of the current ice ranging in elevation from 1050 to 745 m.a.s.l. On the eastern side of the ice mass the outlet glaciers extending down to sea level. The western margin has several small lobes in topographic depressions, with the margin reaching down to 300 m.a.s.l. Topographic highs separate the ice cap into at least 5 main catchments, each having a pair of outlet lobes toward either side of the ice cap. Because of the regional bedrock slope each catchment has its own elevation range. Therefore, as the ELA changes it is possible for some catchments of the ice cap to experience positive mass balance while others have a negative balance. Based on weather observations we estimate the present day ELA to be ~1000 m.a.s.l, meaning mass balance is negative for the majority of the ice cap. By tracking glacier presence/absence in these different catchments, we can reconstruct small changes in the ELA. Another example is the High Ice Cap (informal name) in Milne Land (70.903°N, 25.626°W, 1080 m), East Greenland. Here at least 4 unconformities in ice layers found near the southern margin of the ice cap record changing intervals of accumulation and ablation. Therefore, this location may also be sensitive to slight changes in ELA where you can track an “on-off” type of mass balance switch. To place these ELA changes into temporal context, we propose to investigate proglacial lake environments below the various catchments. We intend to take rock flour as an indicator that the individual catchment is above the ELA. By contrasting the chronology from different catchments we can assemble minor ELA changes. Such an approach could be applied for other ice caps in Greenland and other areas, such as the Quelccaya Ice Cap, Peru.

Literacy Achievement in Nongraded Classrooms

ERIC Educational Resources Information Center

Kreide, Anita Therese

2011-01-01

This longitudinal quantitative study compared literacy achievement of students from second through sixth grade based on two organizational systems: graded (traditional) and nongraded (multiage) classrooms. The California Standards Test (CST) scaled and proficiency scores for English-Language Arts (ELA) were used as the study's independent variable…

Math and ELA Meet at the Common Core

ERIC Educational Resources Information Center

Gardner, Nancy S.; Smith, Nicole

2016-01-01

Math and English language arts seem such disparate content areas but the Common Core State Standards actually draw out their similarities in the teaching and learning process. Both require students to learn grit and perseverance; both ask students to use reasons or evidence to support arguments; both require precision; both require structures to…

Electro-Mechanical Actuator. DC Resonant Link Controller

NASA Technical Reports Server (NTRS)

Schreiner, Kenneth E.

1996-01-01

This report summarizes the work performed on the 68 HP electro-mechanical actuator (EMA) system developed on NASA contract for the Electrical Actuation (ELA) Technology Bridging Program. The system was designed to demonstrate the capability of large, high power linear ELAs for applications such as Thrust Vector Control (TVC) on rocket engines. It consists of a motor controller, drive electronics and a linear actuator capable of up to 32,00 lbs loading at 7.4 inches/second. The drive electronics are based on the Resonant DC link concept and operate at a nominal frequency of 55 kHz. The induction motor is a specially designed high speed, low inertia motor capable of a 68 peak HP. The actuator was originally designed by MOOG Aerospace under an internal R & D program to meet Space Shuttle Main Engine (SSME) TVC requirements. The design was modified to meet this programs linear rate specification of 7.4 inches/second. The motor and driver were tested on a dynamometer at the Martin Marietta Space Systems facility. System frequency response, step response and force-velocity tests were conducted at the MOOG Aerospace facility. A complete description of the system and all test results can be found in the body of the report.

Hypsometric control on glacier mass balance sensitivity in Alaska

NASA Astrophysics Data System (ADS)

McGrath, D.; Sass, L.; Arendt, A. A.; O'Neel, S.; Kienholz, C.; Larsen, C.; Burgess, E. W.

2015-12-01

Mass loss from glaciers in Alaska is dominated by strongly negative surface balances, particularly on small, continental glaciers but can be highly variable from glacier to glacier. Glacier hypsometry can exert significant control on mass balance sensitivity, particularly if the equilibrium line altitude (ELA) is in a broad area of low surface slope. In this study, we explore the spatial variability in glacier response to future climate forcings on the basis of hypsometry. We first derive mass balance sensitivities (30-70 m ELA / 1° C and 40-90 m ELA / 50% decrease in snow accumulation) from the ~50-year USGS Benchmark glaciers mass balance record. We subsequently assess mean climate fields in 2090-2100 derived from the IPCC AR5/CMIP5 RCP 6.0 5-model mean. Over glaciers in Alaska, we find 2-4° C warming and 10-20% increase in precipitation relative to 2006-2015, but a corresponding 0-50% decrease in snow accumulation due to rising temperatures. We assess changes in accumulation area ratios (AAR) to a rising ELA using binned individual glacier hypsometries. For an ELA increase of 150 m, the mean statewide AAR drops by 0.45, representing a 70% reduction in accumulation area on an individual glacier basis. Small, interior glaciers are the primary drivers of this reduction and for nearly 25% of all glaciers, the new ELA exceeds the glacier's maximum elevation, portending eventual loss. The loss of small glaciers, particularly in the drier interior of Alaska will significantly modify streamflow properties (flashy hydrographs, earlier and reduced peak flows, increased interannual variability, warmer temperatures) with poorly understood downstream ecosystem and oceanographic impacts.

Sensitivity of glaciation in the arid subtropical Andes to changes in temperature, precipitation, and solar radiation

NASA Astrophysics Data System (ADS)

Vargo, L. J.; Galewsky, J.; Rupper, S.; Ward, D. J.

2018-04-01

The subtropical Andes (18.5-27 °S) have been glaciated in the past, but are presently glacier-free. We use idealized model experiments to quantify glacier sensitivity to changes in climate in order to investigate the climatic drivers of past glaciations. We quantify the equilibrium line altitude (ELA) sensitivity (the change in ELA per change in climate) to temperature, precipitation, and shortwave radiation for three distinct climatic regions in the subtropical Andes. We find that in the western cordillera, where conditions are hyper-arid with the highest solar radiation on Earth, ELA sensitivity is as high as 34 m per % increase in precipitation, and 70 m per % decrease in shortwave radiation. This is compared with the eastern cordillera, where precipitation is the highest of the three regions, and ELA sensitivity is only 10 m per % increase in precipitation, and 25 m per % decrease in shortwave radiation. The high ELA sensitivity to shortwave radiation highlights the influence of radiation on mass balance of high elevation and low-latitude glaciers. We also consider these quantified ELA sensitivities in context of previously dated glacial deposits from the regions. Our results suggest that glaciation of the humid eastern cordillera was driven primarily by lower temperatures, while glaciations of the arid Altiplano and western cordillera were also influenced by increases in precipitation and decreases in shortwave radiation. Using paleoclimate records from the timing of glaciation, we find that glaciation of the hyper-arid western cordillera can be explained by precipitation increases of 90-160% (1.9-2.6× higher than modern), in conjunction with associated decreases in shortwave radiation of 7-12% and in temperature of 3.5 °C.

Constituents of neutrophil extracellular traps induce in vitro collagen formation in mare endometrium.

PubMed

Rebordão, Maria Rosa; Amaral, Ana; Lukasik, Karolina; Szóstek-Mioduchowska, Anna; Pinto-Bravo, Pedro; Galvão, António; Skarzynski, Dariusz J; Ferreira-Dias, Graça

2018-06-01

Neutrophil extracellular traps (NETs) are DNA complexes carrying nuclear and cytoplasmic proteins, such as elastase (ELA), cathepsin-G (CAT) and myeloperoxidase (MPO). Mare endometrosis is a chronic degenerative process characterized by excessive collagen in endometrium. While NETs fight bacteria that cause endometritis, they may trigger endometrial fibrogenesis. The aim was to evaluate the in vitro effect of some NETs components on mare endometrial fibrogenesis and determine its relationship with histopathology or estrous cycle. Endometrial explants were incubated with NETs components (ELA, CAT, MPO or oxytocin). Collagen type I (COL1) protein and type I and III (COL3) gene transcription were evaluated in follicular and mid-luteal phases endometria (Kenney and Doig type I/IIA and IIB/III). Increased COL1 occurred with all NETs proteins, although endometrial response to each NETs protease depended on estrous cycle and/or endometrial category. Since ELA enhanced COL1 production, NETs persistence might be linked to endometrosis. Estrous cycle influenced COL1 protein concentration and COL3 transcripts, suggesting that follicular phase may favor endometrial collagen production. However, luteal phase endometria with moderate or severe lesions may be also susceptible to fibrotic effects of NETs constituents. These data propose that NETs involvement in chronic endometritis in mares may act as putative endometrial fibrogenic mediators. Copyright © 2018 Elsevier Inc. All rights reserved.

Racial and socioeconomic disparities in body mass index among college students: understanding the role of early life adversity.

PubMed

Curtis, David S; Fuller-Rowell, Thomas E; Doan, Stacey N; Zgierska, Aleksandra E; Ryff, Carol D

2016-10-01

The role of early life adversity (ELA) in the development of health disparities has not received adequate attention. The current study examined differential exposure and differential vulnerability to ELA as explanations for socioeconomic and racial disparities in body mass index (BMI). Data were derived from a sample of 150 college students (M age  = 18.8, SD = 1.0; 45 % African American; 55 % European American) who reported on parents' education and income as well as on exposure to 21 early adverse experiences. Body measurements were directly assessed to determine BMI. In adjusted models, African American students had higher BMI than European Americans. Similarly, background socioeconomic status was inversely associated with BMI. Significant mediation of group disparities through the pathway of ELA was detected, attenuating disparities by approximately 40 %. Furthermore, ELA was more strongly associated with BMI for African Americans than for European Americans. Efforts to achieve health equity may need to more fully consider early adversity.

Jet Injection of 1% buffered lidocaine versus topical ELA-Max for anesthesia before peripheral intravenous catheterization in children: a randomized controlled trial.

PubMed

Spanos, Stephanie; Booth, Rebekah; Koenig, Heidi; Sikes, Kendra; Gracely, Edward; Kim, In K

2008-08-01

Peripheral intravenous (PIV) catheter insertion is a frequent, painful procedure that is often performed with little or no anesthesia. Current approaches that minimize pain for PIV catheter insertion have several limitations: significant delay for onset of anesthesia, inadequate anesthesia, infectious disease exposure risk from needlestick injuries, and patients' needle phobia. Comparison of the anesthetic effectiveness of J-Tip needle-free jet injection of 1% buffered lidocaine to the anesthetic effectiveness of topical 4% ELA-Max for PIV catheter insertion. A prospective, block-randomized, controlled trial comparing J-Tip jet injection of 1% buffered lidocaine to a 30-minute application of 4% ELA-Max for topical anesthesia in children 8 to 15 years old presenting to a tertiary care pediatric emergency department for PIV catheter insertion. All subjects recorded self-reported visual analog scale (VAS) scores for pain at time of enrollment and pain felt following PIV catheter insertion. Jet injection subjects also recorded pain of jet injection. Subjects were videotaped during jet injection and PIV catheter insertion. Videotapes were reviewed by a single blinded reviewer for observer-reported VAS pain scores for jet injection and PIV catheter insertion. Of the 70 children enrolled, 35 were randomized to the J-Tip jet injection group and 35 to the ELA-Max group. Patient-recorded enrollment VAS scores for pain were similar between groups (P = 0.74). Patient-recorded VAS scores were significantly different between groups immediately after PIV catheter insertion (17.3 for J-Tip jet injection vs 44.6 for ELA-Max, P < 0.001). Blinded reviewer assessed VAS scores for pain after PIV catheter insertion demonstrated a similar trend, but the comparison was not statistically significant (21.7 for J-Tip jet injection vs 31.9 ELA-Max, P = 0.23). J-Tip jet injection of 1% buffered lidocaine provided greater anesthesia than a 30-minute application of ELA-Max according to patient self-assessment of pain for children aged 8 to 15 years undergoing PIV catheter insertion.

Reconstruction of past equilibrium line altitude using ice extent data

NASA Astrophysics Data System (ADS)

Visnjevic, Vjeran; Herman, Frederic; Podladchikov, Yuri

2017-04-01

With the end of the Last Glacial Maximum (LGM), about 20 000 years ago, ended the most recent long-lasting cold phase in Earth's history. This last glacial advance left a strong observable imprint on the landscape, such as abandoned moraines, trimlines and other glacial geomorphic features. These features provide a valuable record of past continental climate. In particular, terminal moraines reflect the extent of glaciers and ice-caps, which itself reflects past temperature and precipitation conditions. Here we present an inverse approach, based on a Tikhonov regularization, we have recently developed to reconstruct the LGM mass balance from observed ice extent data. The ice flow model is developed using the shallow ice approximation and solved explicitly using Graphical Processing Units (GPU). The mass balance field, b, is the constrained variable defined by the ice surface S, balance rate β and the spatially variable equilibrium line altitude field (ELA): b = min (β ṡ(S(x,y)- ELA (x,y)),c). (1) where c is a maximum accumulation rate. We show that such a mass balance, and thus the spatially variable ELA field, can be inferred from the observed past ice extent and ice thickness at high resolution and very efficiently. The GPU implementation allows us solve one 1024x1024 grid points forward model run under 0.5s, which significantly reduces the time needed for our inverse method to converge. We start with synthetic test to demonstrate the method. We then apply the method to LGM ice extents of South Island of New Zealand, the Patagonian Andes, where we can see a clear influence of Westerlies on the ELA, and the European Alps. These examples show that the method is capable of constraining spatial variations in mass balance at the scale of a mountain range, and provide us with information on past continental climate.

Mapping the Snow Line Altitude for Large Glacier Samples from Multitemporal Landsat Imagery

NASA Astrophysics Data System (ADS)

Rastner, P.; Nicholson, L. I.; Notarnicola, C.; Prinz, R.; Sailer, R.

2015-12-01

The cryosphere of mountain regions is fastly changing in response to climate change. This is particularly evident in global-scale glacier retreat. Trends in snow cover, however, are more difficult to determine, as annual fluctuations can be very large. Snow is an important parameter in the energy and mass balance of glaciers and the snow line altitude (SLA) at the end of the melting period can be considered as a proxy for the equilibrium line altitude (ELA). By frequently observing the SLA from satellite, region-wide monitoring of glaciers and improved calibration and validation of transient glacier (mass balance) models is possible. In the near future, frequent mapping of the SLA will be strongly facilitated by satellite missions like Sentinel 2A/B, where the same region will be covered every 5 days with 10 m spatial resolution. For this study we have developed an automated tool to derive the SLA for large glacier samples from remote sensing data. The method is first applied in the Ötztal Alps (Austria) where reliable in-situ data of mass balance and ELA are available for several glaciers over a 30-years period. The algorithm currently works with multi-temporal Landsat imagery (1972-2015), digital glacier outlines and a high-quality national DEM. All input datasets are atmospherically and topographically pre-processed before the SLA is automatically retrieved for each glacier. The remote-sensing derived SLA is generally about 200 m lower than the ELA, however, a clear trend in the altitude of the end of summer snow line is detectable (~ 200 m), which is in agreement with the ELA trend observed in the field. After bias correction and conversion to mass balance, the variability in observed mass balance can be well reproduced from the satellite-derived SLA time series. This is promising for application of the approach in other regions.

Exploration Laboratory Analysis

NASA Technical Reports Server (NTRS)

Krihak, M.; Ronzano, K.; Shaw, T.

2016-01-01

The Exploration Laboratory Analysis (ELA) project supports the Exploration Medical Capability (ExMC) risk to minimize or reduce the risk of adverse health outcomes and decrements in performance due to in-flight medical capabilities on human exploration missions. To mitigate this risk, the availability of inflight laboratory analysis instrumentation has been identified as an essential capability for manned exploration missions. Since a single, compact space-ready laboratory analysis capability to perform all exploration clinical measurements is not commercially available, the ELA project objective is to demonstrate the feasibility of emerging operational and analytical capability as a biomedical diagnostics precursor to long duration manned exploration missions. The initial step towards ground and flight demonstrations in fiscal year (FY) 2015 was the down selection of platform technologies for demonstrations in the space environment. The technologies selected included two Small Business Innovation Research (SBIR) performers: DNA Medicine Institutes rHEALTH X and Intelligent Optical Systems later flow assays combined with Holomics smartphone analyzer. The selection of these technologies were based on their compact size, breadth of analytical capability and favorable ability to process fluids in a space environment, among several factors. These two technologies will be advanced to meet ground and flight demonstration success criteria and requirements that will be finalized in FY16. Also, the down selected performers will continue the technology development phase towards meeting prototype deliverables in either late 2016 or 2017.

Exploration Laboratory Analysis

NASA Technical Reports Server (NTRS)

Krihak, M.; Ronzano, K.; Shaw, T.

2016-01-01

The Exploration Laboratory Analysis (ELA) project supports the Exploration Medical Capability (ExMC) risk to minimize or reduce the risk of adverse health outcomes and decrements in performance due to in-flight medical capabilities on human exploration missions. To mitigate this risk, the availability of inflight laboratory analysis instrumentation has been identified as an essential capability for manned exploration missions. Since a single, compact space-ready laboratory analysis capability to perform all exploration clinical measurements is not commercially available, the ELA project objective is to demonstrate the feasibility of emerging operational and analytical capability as a biomedical diagnostics precursor to long duration manned exploration missions. The initial step towards ground and flight demonstrations in fiscal year (FY) 2015 was the downselection of platform technologies for demonstrations in the space environment. The technologies selected included two Small Business Innovation Research (SBIR) performers: DNA Medicine Institute's rHEALTH X and Intelligent Optical System's lateral flow assays combined with Holomic's smartphone analyzer. The selection of these technologies were based on their compact size, breadth of analytical capability and favorable ability to process fluids in a space environment, among several factors. These two technologies will be advanced to meet ground and flight demonstration success criteria and requirements. The technology demonstrations and metrics for success will be finalized in FY16. Also, the downselected performers will continue the technology development phase towards meeting prototype deliverables in either late 2016 or 2017.

Debris-Covered Glaciers in the Sierra Nevada, California, and Their Implications for Snowline Reconstructions

USGS Publications Warehouse

Clark, D.H.; Clark, M.M.; Gillespie, A.R.

1994-01-01

Ice-walled melt ponds on the surfaces of active valley-floor rock glaciers and Matthes (Little Ice Age) moraines in the southern Sierra Nevada indicate that most of these landforms consist of glacier ice under thin (ca. 1 - 10 m) but continuous covers of rock-fall-generated debris. These debris blankets effectively insulate the underlying ice and greatly reduce rates of ablation relative to that of uncovered ice. Such insulation explains the observations that ice-cored rock glaciers in the Sierra, actually debris-covered glaciers, are apparently less sensitive to climatic warming and commonly advance to lower altitudes than do adjacent bare-ice glaciers. Accumulation-area ratios and toe-to-headwall-altitude ratios used to estimate equilibrium-line altitudes (ELAs) of former glaciers may therefore yield incorrect results for cirque glaciers subject to abundant rockfall. Inadvertent lumping of deposits from former debris-covered and bare-ice glaciers partially explains an apparently anomalous regional ELA gradient reported for the pre-Matthes Recess Peak Neoglacial advance. Distinguishing such deposits may be important to studies that rely on paleo-ELA estimates. Moreover, Matthes and Recess Peak ELA gradients along the crest evidently depend strongly on local orographic effects rather than latitudinal climatic trends, indicating that simple linear projections and regional climatic interpretations of ELA gradients of small glaciers may be unreliable.

End of Grant Report

ERIC Educational Resources Information Center

Smarter Balanced Assessment Consortium, 2015

2015-01-01

The Smarter Balanced Assessment Consortium has built a comprehensive learning and assessment system in English Language Arts/Literacy (ELA/L) and mathematics, the components of which work together toward the goal that all students leave high school prepared for postsecondary success in college or career through increased student learning and…

Paleoglaciology of the Tian Shan and Altai Mountains, Central Asia

NASA Astrophysics Data System (ADS)

Blomdin, Robin

Central Asia is home to some of the highest and most spectacular mountain ranges in the world, including the Tian Shan and Altai Mountains, and plays a major role in global and regional climate and hydrology. Understanding the glacial history of this vast region is important for several reasons, but in particular there is a general lack of paleoclimatic data from this highly continental region, at the confluence of major climate systems, and glaciers are sensitive monitors of climate change. This thesis examines the pattern and history of glacial deposition and erosion in the Tian Shan and Altai Mountains using a combined approach including 1) geomorphological mapping, 2) spatial analysis of glacial geomorphology, 3) hypsometry, 4) Equilibrium Line Altitudes (ELA), and 5) 10Be exposure dating of erratic boulders on glacial landforms. Preliminary mapping of the Altai Mountains suggests the area mainly experienced alpine style glaciations, with glacial centers as ice caps and ice fields located around the higher mountainous areas. This is consistent with previous work on the Tian Shan. For the Tian Shan we have new apparent minimum 10Be exposure ages from ~0.2 ka to ~ 180 ka, with large site-specific scatter. Most of our apparent exposure ages come from boulders with an age range between 30 ka to 0.2 ka. Although we recognize that more studies combining mapping, dating and modeling are needed to understand the full history of past glaciation in this region, our conclusions to date include: 1) The oldest recorded glacial event occurred in the Taragay Basin in the Tian Shan, dated to 92.1+/-11.4 ka, and two MIS 2 glacial advances have been recorded on opposite sides of the Ak-Shyrak Range, dated to 16.0+/-3.4 and 17.3+/-4.7 ka respectively. 2) Remote-sensing-based mapping and cosmogenic nuclide dating indicate that Pleistocene glaciations were restricted to the mountains and plateau areas of the Tian Shan. 3) Glaciation ages indicate that glacial events occurred during, MIS 2, 3 and 5. 4) There are no regional spatial trends in changes in ELA (DeltaELA) however, when comparing the distribution of ELAs to the hypsometric signature (area elevation relationship) of individual catchments across the Tian Shan, there is a range of cases from valleys experiencing "typical" or "extensive" modes of glaciation, where paleo ELAs coincide with hypsometric maxima (peaks in area-elevation curves), to valleys with more complicated signatures, either reflecting "dynamic" or "limited" glaciations at H MAX. This suggests that in future work "typical" catchments should be targeted for geochronological studies and paleo-ELA reconstructions. 5) Finally, when comparing deglaciation ages to global and regional climate records we observe both northern hemispheric and monsoonal signatures as potential drivers behind glacial expansions in the Tian Shan.

American PARCC and SBAC and Their Implications on the Construction of English Assessment System in China

ERIC Educational Resources Information Center

Zhang, Haiyan; Kang, Kai

2017-01-01

The Partnership for Assessment of Readiness for College and Careers (PARCC) and Smarter Balanced Assessment Systems (SBAC) started in the 2014-2015 academic year and has been regarded by many in the field as a radical effort to improve the American English Language Art (ELA) educational standards. These two consortia, being aligned with Common…

40 HP Electro-Mechanical Actuator

NASA Technical Reports Server (NTRS)

Fulmer, Chris

1996-01-01

This report summarizes the work performed on the 40 BP electro-mechanical actuator (EMA) system developed on NASA contract NAS3-25799 for the NASA National Launch System and Electrical Actuation (ELA) Technology Bridging Programs. The system was designed to demonstrate the capability of large, high power linear ELA's for applications such as Thrust Vector Control (TVC) on rocket engines. It consists of a motor controller, high frequency power source, drive electronics and a linear actuator. The power source is a 25kVA 20 kHz Mapham inverter. The drive electronics are based on the pulse population modulation concept and operate at a nominal frequency of 40 kHz. The induction motor is a specially designed high speed, low inertia motor capable of a 68 peak HP. The actuator was originally designed by MOOG Aerospace under an internal R & D program to meet Space Shuttle Main Engine (SSME) TVC requirements. The design was modified to meet this programs linear rate specification of 7.4 inches/second. The motor and driver were tested on a dynamometer at the Martin Marietta Space Systems facility. System frequency response and step response tests were conducted at the Marshall Space Flight Center facility. A complete description of the system and all test results can be found in the body of the report.

Direct Reading Instruction and the NYS ELA

ERIC Educational Resources Information Center

Jones-Carey, Margaret H.

2013-01-01

This study analyzed the impact of classroom based reading instruction ("direct instruction") on the standardized test scores of 6th grade students as measured by the New York State English Language Arts assessment (NYS ELA). It was hypothesized that the implementation of direct instruction in reading in grade 6 would improve NYS ELA…

Cross-District Collaboration: Curriculum and Professional Development

ERIC Educational Resources Information Center

Short, Deborah J.; Cloud, Nancy; Morris, Patricia; Motta, Julie

2012-01-01

Secondary English as a second language (ESL) curricula that address four levels of ESL proficiency and prepare students for the English language arts (ELA) curricula and state-mandated ELA tests are not common. A curriculum jointly developed by two districts is even rarer. Yet two urban districts in Rhode Island undertook such a curriculum…

Self-Portraits Wanted!

ERIC Educational Resources Information Center

Nadeau, Pamela A.

2012-01-01

When the author was training to be an art educator, she was employed as a sixth-grade English Language Arts (ELA) teacher. When the author moved into the art teacher position at the very same school, she borrowed her cooperating teacher Kim Donovan's ELA project, in which students will design an 1800s-style "wanted poster," and transformed it into…

Measuring Instructional Differentiation in a Large-Scale Experiment

ERIC Educational Resources Information Center

Williams, Ryan T.; Swanlund, Andrew; Miller, Shazia; Konstantopoulos, Spyros; Eno, Jared; van der Ploeg, Arie; Meyers, Coby

2014-01-01

This study operationalizes four measures of instructional differentiation: one for Grade 2 English language arts (ELA), one for Grade 2 mathematics, one for Grade 5 ELA, and one for Grade 5 mathematics. Our study evaluates their measurement properties of each measure in a large field experiment: the Indiana Diagnostic Assessment Tools Study, which…

Slicing and Dicing the ELA Common Core Standards

ERIC Educational Resources Information Center

Goatley, Virginia

2012-01-01

The English Language Arts Common Core State Standards (ELA CCSS) come at a time when many reading teachers, literacy coaches, and classroom teachers seek more extensive literacy practices than the policy mandates of No Child Left Behind and Reading First. These initiatives placed requirements for instruction in core aspects of reading at the…

Shock Compression of Metal Crystals: A Comparison of Eulerian and Lagrangian Elastic-Plastic Theories

DTIC Science & Technology

2014-11-01

incorporate the right Cauchy–Green strain tensor E, a function of the ( elas - tic) deformation gradient and its transpose. Such theories have been used...been compared for several anisotropic metallic single crystals (Al, Cu and Mg), with elas - tic constants of up to order four included. Differences

Teaching With(out) Technology: Secondary English Teachers and Classroom Technology Use

ERIC Educational Resources Information Center

Flanagan, Sara; Shoffner, Melanie

2013-01-01

Technology plays an integral role in the English Language Arts (ELA) classroom today, yet teachers and teacher educators continue to develop understandings of how technology influences pedagogy. This qualitative study explored how and why two ELA teachers used different technologies in the secondary English classroom to plan for and deliver…

Promoting a Culture of Collaboration and Reflection through a Professional Learning Community

ERIC Educational Resources Information Center

Murdaugh, Erica Charlanda Russell

2017-01-01

The purpose of this qualitative Action Research Study was to describe eight elementary English Language Arts (ELA) teachers' perceptions of a Professional Learning Community (PLC). The teacher-participants' opinions about the PLC were used to improve the existing PLC to promote a more reflective and collaborative environment where ELA teachers…

Analysis of ELA-DQB exon 2 polymorphism in Argentine Creole horses by PCR-RFLP and PCR-SSCP.

PubMed

Villegas-Castagnasso, E E; Díaz, S; Giovambattista, G; Dulout, F N; Peral-García, P

2003-08-01

The second exon of equine leucocyte antigen (ELA)-DQB genes was amplified from genomic DNA of 32 Argentine Creole horses by PCR. Amplified DNA was analysed by PCR-restriction fragment length polymorphism (RFLP) and PCR-single-strand conformation polymorphism (SSCP). The PCR-RFLP analysis revealed two HaeIII patterns, four RsaI patterns, five MspI patterns and two HinfI patterns. EcoRI showed no variation in the analysed sample. Additional patterns that did not account for known exon 2 DNA sequences were observed, suggesting the existence of novel ELA-DQB alleles. PCR-SSCP analysis exhibited seven different band patterns, and the number of bands per animal ranged from four to nine. Both methods indicated that at least two DQB genes are present. The presence of more than two alleles in each animal showed that the primers employed in this work are not specific for a unique DQB locus. The improvement of this PCR-RFLP method should provide a simple and rapid technique for an accurate definition of ELA-DQB typing in horses.

Moderate Aerobic Training Improves Cardiorespiratory Parameters in Elastase-Induced Emphysema

PubMed Central

Henriques, Isabela; Lopes-Pacheco, Miquéias; Padilha, Gisele A.; Marques, Patrícia S.; Magalhães, Raquel F.; Antunes, Mariana A.; Morales, Marcelo M.; Rocha, Nazareth N.; Silva, Pedro L.; Xisto, Débora G.; Rocco, Patricia R. M.

2016-01-01

Aim: We investigated the therapeutic effects of aerobic training on lung mechanics, inflammation, morphometry and biological markers associated with inflammation, and endothelial cell damage, as well as cardiac function in a model of elastase-induced emphysema. Methods: Eighty-four BALB/c mice were randomly allocated to receive saline (control, C) or 0.1 IU porcine pancreatic elastase (emphysema, ELA) intratracheally once weekly for 4 weeks. After the end of administration period, once cardiorespiratory impairment associated with emphysema was confirmed, each group was further randomized into sedentary (S) and trained (T) subgroups. Trained mice ran on a motorized treadmill, at moderate intensity, 30 min/day, 3 times/week for 4 weeks. Results: Four weeks after the first instillation, ELA animals, compared to C, showed: (1) reduced static lung elastance (Est,L) and levels of vascular endothelial growth factor (VEGF) in lung tissue, (2) increased elastic and collagen fiber content, dynamic elastance (E, in vitro), alveolar hyperinflation, and levels of interleukin-1β and tumor necrosis factor (TNF)-α, and (3) increased right ventricular diastolic area (RVA). Four weeks after aerobic training, ELA-T group, compared to ELA-S, was associated with reduced lung hyperinflation, elastic and collagen fiber content, TNF-α levels, and RVA, as well as increased Est,L, E, and levels of VEGF. Conclusion: Four weeks of regular and moderate intensity aerobic training modulated lung inflammation and remodeling, thus improving pulmonary function, and reduced RVA and pulmonary arterial hypertension in this animal model of elastase-induced emphysema. PMID:27536247

Exploring the ϒ (4 S ,5 S ,6 S )→hb(1 P )η hidden-bottom hadronic transitions

NASA Astrophysics Data System (ADS)

Zhang, Yawei; Li, Gang

2018-01-01

Recently, the Belle Collaboration has reported the measurement of the spin-flipping transition ϒ (4 S )→hb(1 P )η with an unexpectedly large branching ratio: B (ϒ (4 S )→hb(1 P )η )=(2.18 ±0.11 ±0.18 )×10-3 . Such a large branching fraction contradicts with the anticipated suppression for the spin flip. In this work, we examine the effects induced by intermediate bottomed meson loops and point out that these effects are significantly important. Using the effective Lagrangian approach (ELA), we find the experimental data on ϒ (4 S )→hb(1 P )η can be accommodated with the reasonable inputs. We then explore the decays ϒ (5 S ,6 S )→hb(1 P )η and find that these two channels also have sizable branching fractions. We also calculate these processes in the framework of nonrelativistic effective field theory (NREFT). For the decays ϒ (4 S )→hb(1 P )η , the NREFT results are at the same order of magnitude but smaller than the ELA results by a factor of 2 to 5. For the decays ϒ (5 S ,6 S )→hb(1 P )η , the NREFT results are smaller than the ELA results by approximately 1 order of magnitude. We suggest a future experiment Belle-II to search for the ϒ (5 S ,6 S )→hb(1 P )η decays, which will be helpful for understanding the transition mechanism.

A Plant Proteinase Inhibitor from Enterolobium contortisiliquum Attenuates Pulmonary Mechanics, Inflammation and Remodeling Induced by Elastase in Mice

PubMed Central

Theodoro-Júnior, Osmar Aparecido; Righetti, Renato Fraga; Almeida-Reis, Rafael; Martins-Oliveira, Bruno Tadeu; Oliva, Leandro Vilela; Prado, Carla Máximo; Saraiva-Romanholo, Beatriz Mangueira; Leick, Edna Aparecida; Pinheiro, Nathalia Montouro; Lobo, Yara Aparecida; Martins, Mílton de Arruda; Oliva, Maria Luiza Vilela; Tibério, Iolanda de Fátima Lopes Calvo

2017-01-01

Proteinase inhibitors have been associated with anti-inflammatory and antioxidant activities and may represent a potential therapeutic treatment for emphysema. Our aim was to evaluate the effects of a plant Kunitz proteinase inhibitor, Enterolobium contortisiliquum trypsin inhibitor (EcTI), on several aspects of experimental elastase-induced pulmonary inflammation in mice. C57/Bl6 mice were intratracheally administered elastase (ELA) or saline (SAL) and were treated intraperitoneally with EcTI (ELA-EcTI, SAL-EcTI) on days 1, 14 and 21. On day 28, pulmonary mechanics, exhaled nitric oxide (ENO) and number leucocytes in the bronchoalveolar lavage fluid (BALF) were evaluated. Subsequently, lung immunohistochemical staining was submitted to morphometry. EcTI treatment reduced responses of the mechanical respiratory system, number of cells in the BALF, and reduced tumor necrosis factor-α (TNF-α), matrix metalloproteinase-9 (MMP-9), matrix metalloproteinase-12 (MMP-12), tissue inhibitor of matrix metalloproteinase (TIMP-1), endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS)-positive cells and volume proportion of isoprostane, collagen and elastic fibers in the airways and alveolar walls compared with the ELA group. EcTI treatment reduced elastase induced pulmonary inflammation, remodeling, oxidative stress and mechanical alterations, suggesting that this inhibitor may be a potential therapeutic tool for chronic obstructive pulmonary disease (COPD) management. PMID:28216579

Increased Nucleosomes and Neutrophil Activation Link to Disease Progression in Patients with Scrub Typhus but Not Murine Typhus in Laos.

PubMed

Paris, Daniel H; Stephan, Femke; Bulder, Ingrid; Wouters, Diana; van der Poll, Tom; Newton, Paul N; Day, Nicholas P J; Zeerleder, Sacha

2015-01-01

Cell-mediated immunity is essential in protection against rickettsial illnesses, but the role of neutrophils in these intracellular vasculotropic infections remains unclear. This study analyzed the plasma levels of nucleosomes, FSAP-activation (nucleosome-releasing factor), and neutrophil activation, as evidenced by neutrophil-elastase (ELA) complexes, in sympatric Lao patients with scrub typhus and murine typhus. In acute scrub typhus elevated nucleosome levels correlated with lower GCS scores, raised respiratory rate, jaundice and impaired liver function, whereas neutrophil activation correlated with fibrinolysis and high IL-8 plasma levels, a recently identified predictor of severe disease and mortality. Nucleosome and ELA complex levels were associated with a 4.8-fold and 4-fold increased risk of developing severe scrub typhus, beyond cut off values of 1,040 U/ml for nucleosomes and 275 U/ml for ELA complexes respectively. In murine typhus, nucleosome levels associated with pro-inflammatory cytokines and the duration of illness, while ELA complexes correlated strongly with inflammation markers, jaundice and increased respiratory rates. This study found strong correlations between circulating nucleosomes and neutrophil activation in patients with scrub typhus, but not murine typhus, providing indirect evidence that nucleosomes could originate from neutrophil extracellular trap (NET) degradation. High circulating plasma nucleosomes and ELA complexes represent independent risk factors for developing severe complications in scrub typhus. As nucleosomes and histones exposed on NETs are highly cytotoxic to endothelial cells and are strongly pro-coagulant, neutrophil-derived nucleosomes could contribute to vascular damage, the pro-coagulant state and exacerbation of disease in scrub typhus, thus indicating a detrimental role of neutrophil activation. The data suggest that increased neutrophil activation relates to disease progression and severe complications, and increased plasma levels of nucleosomes and ELA complexes represent independent risk factors for developing severe scrub typhus.

Increased Nucleosomes and Neutrophil Activation Link to Disease Progression in Patients with Scrub Typhus but Not Murine Typhus in Laos

PubMed Central

Paris, Daniel H.; Stephan, Femke; Bulder, Ingrid; Wouters, Diana; van der Poll, Tom; Newton, Paul N.; Day, Nicholas P. J.; Zeerleder, Sacha

2015-01-01

Cell-mediated immunity is essential in protection against rickettsial illnesses, but the role of neutrophils in these intracellular vasculotropic infections remains unclear. This study analyzed the plasma levels of nucleosomes, FSAP-activation (nucleosome-releasing factor), and neutrophil activation, as evidenced by neutrophil-elastase (ELA) complexes, in sympatric Lao patients with scrub typhus and murine typhus. In acute scrub typhus elevated nucleosome levels correlated with lower GCS scores, raised respiratory rate, jaundice and impaired liver function, whereas neutrophil activation correlated with fibrinolysis and high IL-8 plasma levels, a recently identified predictor of severe disease and mortality. Nucleosome and ELA complex levels were associated with a 4.8-fold and 4-fold increased risk of developing severe scrub typhus, beyond cut off values of 1,040 U/ml for nucleosomes and 275 U/ml for ELA complexes respectively. In murine typhus, nucleosome levels associated with pro-inflammatory cytokines and the duration of illness, while ELA complexes correlated strongly with inflammation markers, jaundice and increased respiratory rates. This study found strong correlations between circulating nucleosomes and neutrophil activation in patients with scrub typhus, but not murine typhus, providing indirect evidence that nucleosomes could originate from neutrophil extracellular trap (NET) degradation. High circulating plasma nucleosomes and ELA complexes represent independent risk factors for developing severe complications in scrub typhus. As nucleosomes and histones exposed on NETs are highly cytotoxic to endothelial cells and are strongly pro-coagulant, neutrophil-derived nucleosomes could contribute to vascular damage, the pro-coagulant state and exacerbation of disease in scrub typhus, thus indicating a detrimental role of neutrophil activation. The data suggest that increased neutrophil activation relates to disease progression and severe complications, and increased plasma levels of nucleosomes and ELA complexes represent independent risk factors for developing severe scrub typhus. PMID:26317419

The Impact of the Fountas and Pinnell Benchmark Assessment System on Third Grade South Carolina Ready English Language Arts Scores

ERIC Educational Resources Information Center

Harrington, Shanika

2017-01-01

The purpose of this research study was to evaluate the impact of the district's use of the Fountas and Pinnell Benchmark Assessment System on 3rd grade students' reading achievement as measured by the SC READY ELA test. Educators are increasingly using assessment data in determining students' knowledge and progress. Brady, 2011 stated that…

Detecting evidence of luteal activity by least-squares quantitative basal temperature analysis against urinary progesterone metabolites and the effect of wake-time variability.

PubMed

Bedford, Jennifer L; Prior, Jerilynn C; Hitchcock, Christine L; Barr, Susan I

2009-09-01

To assess computerised least-squares analysis of quantitative basal temperature (LS-BT) against urinary pregnanediol glucuronide (PdG) as an indirect measure of ovulation, and to evaluate the stability of LS-QBT to wake-time variation. Cross-sectional study of 40 healthy, normal-weight, regularly menstruating women aged 19-34. Participants recorded basal temperature and collected first void urine daily for one complete menstrual cycle. Evidence of luteal activity (ELA), an indirect ovulation indicator, was assessed using Kassam's PdG algorithm, which identifies a sustained 3-day PdG rise, and the LS-QBT algorithm, by determining whether the temperature curve is significantly biphasic. Cycles were classified as ELA(+) or ELA(-). We explored the need to pre-screen for wake-time variations by repeating the analysis using: (A) all recorded temperatures, (B) wake-time adjusted temperatures, (C) temperatures within 2h of average wake-time, and (D) expert reviewed temperatures. Relative to PdG, classification of cycles as ELA(+) was 35 of 36 for LS-QBT methods A and B, 33 of 34 (method C) and 30 of 31 (method D). Classification of cycles as ELA(-) was 1 of 4 (methods A and B) and 0 of 3 (methods C and D). Positive predictive value was 92% for methods A-C and 91% for method D. Negative predictive value was 50% for methods A and B and 0% for methods C and D. Overall accuracy was 90% for methods A and B, 89% for method C and 88% for method D. The day of a significant temperature increase by LS-QBT and the first day of a sustained PdG rise were correlated (r=0.803, 0.741, 0.651, 0.747 for methods A-D, respectively, all p<0.001). LS-QBT showed excellent detection of ELA(+) cycles (sensitivity, positive predictive value) but poor detection of ELA(-) cycles (specificity, negative predictive value) relative to urinary PdG. Correlations between the methods and overall accuracy were good and similar for all analyses. Findings suggest that LS-QBT is robust to wake-time variability and that expert interpretation is unnecessary. This method shows promise for use as an epidemiological tool to document cyclic progesterone increase. Further validation relative to daily transvaginal ultrasound is required.

ElaC encodes a novel binuclear zinc phosphodiesterase.

PubMed

Vogel, Andreas; Schilling, Oliver; Niecke, Manfred; Bettmer, Jorg; Meyer-Klaucke, Wolfram

2002-08-09

ElaC is a widespread gene found in eubacteria, archaebacteria, and mammals with a highly conserved sequence. Two human ElaC variants were recently associated with cancer (Tavtigian, S. V., Simard, J., Teng, D. H., Abtin, V., Baumgard, M., Beck, A., Camp, N. J., Carillo, A. R., Chen, Y., Dayananth, P., Desrochers, M., Dumont, M., Farnham, J. M., Frank, D., Frye, C., Ghaffari, S., Gupte, J. S., Hu, R., Iliev, D., Janecki, T., Kort, E. N., Laity, K. E., Leavitt, A., Leblanc, G., McArthur-Morrison, J., Pederson, A., Penn, B., Peterson, K. T., Reid, J. E., Richards, S., Schroeder, M., Smith, R., Snyder, S. C., Swedlund, B., Swensen, J., Thomas, A., Tranchant, M., Woodland, A. M., Labrie, F., Skolnick, M. H., Neuhausen, S., Rommens, J., and Cannon-Albright, L. A. (2001) Nat. Genet. 27, 172-180; Yanaihara, N., Kohno, T., Takakura, S., Takei, K., Otsuka, A., Sunaga, N., Takahashi, M., Yamazaki, M., Tashiro, H., Fukuzumi, Y., Fujimori, Y., Hagiwara, K., Tanaka, T., and Yokota, J. (2001) Genomics 72, 169-179). Analysis of the primary sequence indicates homology to an arylsulfatase and predicts a metallo-beta-lactamase fold. At present, no ElaC gene product has been investigated. We cloned the Escherichia coli ElaC gene and purified the recombinant gene product. An enzymatic analysis showed that ElaC does not encode an arylsulfatase but rather encodes a phosphodiesterase that hydrolyzes bis(p-nitrophenyl)phosphate with a k(cat) of 59 s(-1) and K' of 4 mm. Kinetic analysis of the dimeric enzyme revealed positive cooperativity for the substrate bis(p-nitrophenyl)phosphate with a Hill coefficient of 1.6, whereas hydrolysis of the substrate thymidine-5'-p-nitrophenyl phosphate followed Michaelis-Menten kinetics. Furthermore, the enzyme is capable of binding two zinc or two iron ions. However, it displays phosphodiesterase activity only in the zinc form. The metal environment characterized by zinc K-edge x-ray absorption spectroscopy was modeled with two histidine residues, one carboxylate group, and 1.5 oxygen atoms. This corresponds to the coordination found in other metallo-beta-lactamase domain proteins. Phosphodiesterase activity is strongly dependent on the presence of zinc. These results identify the currently unassigned gene product ElaC to be a novel binuclear zinc phosphodiesterase.

Engagement with Cognitively-Based Compassion Training is associated with reduced salivary C-reactive protein from before to after training in foster care program adolescents.

PubMed

Pace, Thaddeus W W; Negi, Lobsang Tenzin; Dodson-Lavelle, Brooke; Ozawa-de Silva, Brendan; Reddy, Sheethal D; Cole, Steven P; Danese, Andrea; Craighead, Linda W; Raison, Charles L

2013-02-01

Children exposed to early life adversity (ELA) have been shown to have elevated circulating concentrations of inflammatory markers that persist into adulthood. Increased inflammation in individuals with ELA is believed to drive the elevated risk for medical and psychiatric illness in the same individuals. This study sought to determine whether Cognitively Based Compassion Training (CBCT) reduced C-reactive protein (CRP) in adolescents in foster care with high rates of ELA, and to evaluate the relationship between CBCT engagement and changes in CRP given prior evidence from our group for an effect of practice on inflammatory markers. It was hypothesized that increasing engagement would be associated with reduced CRP from baseline to the 6-week assessment. Seventy-one adolescents in the Georgia foster care system (31 females), aged 13-17, were randomized to either 6 weeks of CBCT or a wait-list condition. State records were used to obtain information about each participant's history of trauma and neglect, as well as reason for placement in foster care. Saliva was collected before and again after 6 weeks of CBCT or the wait-list condition. Participants in the CBCT group completed practice diaries as a means of assessing engagement with the CBCT. No difference between groups was observed in salivary CRP concentrations. Within the CBCT group, practice sessions during the study correlated with reduced CRP from baseline to the 6-week assessment. Engagement with CBCT may positively impact inflammatory measures relevant to health in adolescents at high risk for poor adult functioning as a result of significant ELA, including individuals placed in foster care. Longer term follow-up will be required to evaluate if these changes are maintained and translate into improved health outcomes. Copyright © 2012 Elsevier Ltd. All rights reserved.

Teachers' Perceptions on Preparedness and Supports to Implement the English Language Arts Common Core State Standards

ERIC Educational Resources Information Center

Fernandez, Maria Clara

2017-01-01

The purpose of this study was to: (1) describe elementary teachers' perceptions on their preparedness to implement the English Language Arts Common Core State Standards (ELA-CCSS); (2) determine how perceptions influenced changes in instructional practices; and (3) to explore ELA-CCSS implementation challenges and/or barriers in supporting teacher…

Integrating the English Language Arts Common Core State Standards into Physical Education

ERIC Educational Resources Information Center

James, Alisa R.; Bullock, Kerri

2015-01-01

Physical education teachers are expected to implement the English language arts (ELA) Common Core State Standards (CCSS) in their instruction. This has proved to be challenging for many physical educators. The purpose of this article is to provide developmentally appropriate examples of how to incorporate the ELA CCSS into physical education,…

Relations between the CCSS and RTI in Literacy and Language

ERIC Educational Resources Information Center

Wixson, Karen K.; Lipson, Marjorie Y.

2012-01-01

Initiatives such as Response to Intervention (RTI) and the Common Core State Standards for English Language Arts (CCSS-ELA) have the potential to positively impact progress toward the goal of literacy for all. Because the CCSS-ELA will guide the content of the curriculum, instruction and assessment in the large number of adopting states, they will…

Common Core Preparation in Special Education Teacher Education Programs: Beginning the Conversation

ERIC Educational Resources Information Center

Murphy, Michelle R.; Marshall, Kathleen J.

2015-01-01

The Common Core State Standards (CCSS) were developed to encourage a common focus of instruction and evaluation in the areas of mathematics, reading/language arts, writing, speaking, and listening. As of 2011, all but five states have adopted CCSS for math and English Language Arts (ELA), with another adopting only the standards for ELA. With…

Social Justice Teaching: Adopting a Critical Pedagogy to Negotiate Old and New Literacies

ERIC Educational Resources Information Center

Bender-Slack, Delane

2009-01-01

Literacy is intricately linked to social justice, and it can shape the learning that occurs in our English language arts (ELA) classrooms. Challenging the notion of the traditional secondary ELA classroom--as centered on literature and old literacies--I advocate utilizing a critical pedagogy with a new literacy approach that employs texts to teach…

Strengthen Your Music Program by Incorporating Aspects of the ELA Common Core State Standards

ERIC Educational Resources Information Center

Smith, Nancy Thompson

2014-01-01

Implementation of the English Language Arts (ELA) Common Core State Standards (CCSS) reduces the traditional separation between the study of different subjects. Increased focus on nonfiction reading and writing means more incorporation of other content, such as music, into language arts classes. CCSS's emphasis on speaking and writing across…

Teachers' Perspective on Using Technology as an Instructional Tool

ERIC Educational Resources Information Center

Davidson, Leavery Y. Jefferson

2012-01-01

Federal mandates require technology use in the classroom, but not all English language arts (ELA) teachers have implemented technology as an integral part of teaching. The purpose of this qualitative case study was to investigate why ELA teachers in 2 local high schools rarely or never use technology as an instructional tool. The study was…

Teachers' Perspective on Using Technology as an Instructional Tool

ERIC Educational Resources Information Center

Davidson, Leavery Y. Jefferson; Richardson, Martha; Jones, Don

2014-01-01

Federal mandates require technology use in the classroom, but not all English language arts (ELA) teachers have implemented technology as an integral part of teaching. The purpose of this qualitative case study was to investigate why ELA teachers in 2 local high schools rarely or never use technology as an instructional tool. The study was…

The English Language Arts Assessment: Knocking at Our Door.

ERIC Educational Resources Information Center

Peterson, Scott

2003-01-01

Describes how Michigan's English Language Arts Assessment (ELA) takes parts of the old fifth-grade writing assessment and fourth-grade reading tests, adds new elements, and wraps everything around a theme. Presents a seven-step activity to help prepare fourth graders for the ELA. Concludes that the overall impact on scores is not known. (SG)

Heterozygous M1V variant of ELA-2 gene mutation associated with G-CSF refractory severe congenital neutropenia.

PubMed

Setty, Bhuvana A; Yeager, Nicholas D; Bajwa, Rajinder P

2011-09-01

Severe congenital neutropenia is an autosomal recessive disorder characterized by maturation arrest at the promyelocyte/myelocyte phase in the bone marrow, absolute neutrophil count <0.5 × 10(9) /L and recurrent bacterial infections. Homozygous mutations of either HAX-1 or ELA-2 have been described. We report the case of a premature male infant with congenital neutropenia, associated with multiple infections, refractory to treatment with granulocyte colony stimulating factor who subsequently underwent matched sibling donor stem-cell transplant. He was found to be heterozygous for the M1V variant of the ELA-2 gene that we postulate to be causative for his severe neutropenia Copyright © 2011 Wiley-Liss, Inc.

Tropical climate at the last glacial maximum inferred from glacier mass-balance modeling

USGS Publications Warehouse

Hostetler, S.W.; Clark, P.U.

2000-01-01

Model-derived equilibrium line altitudes (ELAs) of former tropical glaciers support arguments, based on other paleoclimate data, for both the magnitude and spatial pattern of terrestrial cooling in the tropics at the last glacial maximum (LGM). Relative to the present, LGM ELAs were maintained by air temperatures that were 3.5??to 6.6 ??C lower and precipitation that ranged from 63% wetter in Hawaii to 25% drier on Mt. Kenya, Africa. Our results imply the need for a ~3 ??C cooling of LGM sea surface temperatures in the western Pacific warm pool. Sensitivity tests suggest that LGM ELAs could have persisted until 16,000 years before the present in the Peruvian Andes and on Papua, New Guinea.

Comparative Evaluation of Triphala and Ela Decoction With 0.2% Chlorhexidine as Mouthwash in the Treatment of Plaque-Induced Gingivitis and Halitosis: A Randomized Controlled Clinical Trial.

PubMed

Mamgain, Pratibha; Kandwal, Abhishek; Mamgain, Ravindra K

2016-12-08

Present study evaluates efficacy of Trifala and Ela as plaque controlling agent and compares it with chlorhexidine. To evaluate Antigingivitis, Antiplaque and Antihalitosis effect of Triphala and Ela decoction. A randomized sample of 60 patients with plaque induced gingivitis was enrolled and equally divided into two groups group A and group B. Group A was given Trifala and Ela decoction and Group B Chlorehexidine mouthwash for 21 days twice daily. Gingival inflammation index, plaque index and Organoleptic scoring scale was recorded at baseline, 14th day and 21st day. Comparing the plaque index for Group A with group B the reduction in from baseline to 14 day was 42.59 % and 38.62% respectively while from baseline to 21 day was 56.20% and 68.57% respectively. On comparing Gingival index for group A with group B the reduction from baseline to 14 day was 31.95% and 38.62 % respectively while from baseline to 21 day was 69.95 % and 68.57% respectively. Halitosis Percentage reduction at 14th day from base line was 33.33% and 38.18%; at 21 day from baseline 66.66% and 72.72% respectively for group A and group B. No statistical significant difference for intergroup comparison was found using paired t test. Intra group analysis using unpaired t test was significant for all the indices at different time intervals. Triphala and Ela decoction is organic, easy to prepare economical and equally effective as compared to chlorhexidine mouthwash. © The Author(s) 2016.

Neutrophil elastase and granulocyte colony-stimulating factor receptor mutation analyses and leukemia evolution in severe congenital neutropenia patients belonging to the original Kostmann family in northern Sweden.

PubMed

Carlsson, Göran; Aprikyan, Andrew A G; Ericson, Kim Göransdotter; Stein, Steve; Makaryan, Vahagn; Dale, David C; Nordenskjöld, Magnus; Fadeel, Bengt; Palmblad, Jan; Hentera, Jan-Inge

2006-05-01

Severe congenital neutropenia (SCN) or Kostmann syndrome was originally reported to be an autosomal recessive disease of neutrophil production causing recurrent, life-threatening infections. Mutations in the neutrophil elastase gene (ELA-2) have previously been identified in patients with sporadic or autosomal dominant SCN. We studied 14 individuals (four patients with SCN and ten close relatives) belonging to the original Kostmann family in northern Sweden for mutations in the ELA-2 and the granulocyte colony-stimulating factor (G-CSF) receptor genes. One patient belonging to the original Kostmann family harbored a novel heterozygous ELA-2 mutation (g.2310T-->A;Leu92His) that was not inherited from her parents. The mutation was identified in DNA isolated from both whole blood and skin fibroblasts, suggesting a sporadic de novo mutation. As a young adult this patient sequentially acquired two mutations in the gene for the G-CSF receptor (G-CSFR) and therefore recently received a hematopoietic stem cell transplant, due to the risk of evolution to leukemia. Moreover, another patient developed acute leukemia and was treated with transplantation. No pathogenic ELA-2 or G-CSFR gene mutations were found in this patient or the other two patients, nor in any healthy relative. Our data are the first to document leukemia evolution and G-CSFR gene mutations in the original Kostmann kindred. In addition, our findings indicate that ELA-2 mutations are not the primary cause of SCN in the Swedish Kostmann family.

Genetic risk factors for insidious equine recurrent uveitis in Appaloosa horses.

PubMed

Fritz, K L; Kaese, H J; Valberg, S J; Hendrickson, J A; Rendahl, A K; Bellone, R R; Dynes, K M; Wagner, M L; Lucio, M A; Cuomo, F M; Brinkmeyer-Langford, C L; Skow, L C; Mickelson, J R; Rutherford, M S; McCue, M E

2014-06-01

Appaloosa horses are predisposed to equine recurrent uveitis (ERU), an immune-mediated disease characterized by recurring inflammation of the uveal tract in the eye, which is the leading cause of blindness in horses. Nine genetic markers from the ECA1 region responsible for the spotted coat color of Appaloosa horses, and 13 microsatellites spanning the equine major histocompatibility complex (ELA) on ECA20, were evaluated for association with ERU in a group of 53 Appaloosa ERU cases and 43 healthy Appaloosa controls. Three markers were significantly associated (corrected P-value <0.05): a SNP within intron 11 of the TRPM1 gene on ECA1, an ELA class I microsatellite located near the boundary of the ELA class III and class II regions and an ELA class II microsatellite located in intron 1 of the DRA gene. Association between these three genetic markers and the ERU phenotype was confirmed in a second population of 24 insidious ERU Appaloosa cases and 16 Appaloosa controls. The relative odds of being an ERU case for each allele of these three markers were estimated by fitting a logistic mixed model with each of the associated markers independently and with all three markers simultaneously. The risk model using these markers classified ~80% of ERU cases and 75% of controls in the second population as moderate or high risk, and low risk respectively. Future studies to refine the associations at ECA1 and ELA loci and identify functional variants could uncover alleles conferring susceptibility to ERU in Appaloosa horses. © 2014 Stichting International Foundation for Animal Genetics.

Florida SpringBoard® Schools Efficacy Study. Statistical Report 2015-1

ERIC Educational Resources Information Center

Niu, Sunny; Li, Jun; Merriman, Jennifer; Matos-Elefonte, Haifa

2015-01-01

In this study, we compare SpringBoard® (SB) schools that had continuously used the SB English Language Arts (ELA) curriculum for at least three years with comparable non-SB schools. For high schools, the outcomes examined were school-level AP® participation and performance for a) all AP subjects, b) ELA and social science AP subjects, and c) ELA…

Reading Achievement and Reading Efficacy Changes for Middle School Students with Disabilities through Blended Learning Instruction

ERIC Educational Resources Information Center

Pace, Jesse R.; Mellard, Daryl F.

2016-01-01

This study evaluated the effects of a blended learning instructional experience for sixth-grade students in an English/language arts (ELA) course. Students at two treatment schools participated in a blended learning instructional paradigm, and their ELA test scores were compared to one comparison school that used a face-to-face delivery. Other…

Project ELaNa and NASA's CubeSat Initiative

NASA Technical Reports Server (NTRS)

Skrobot, Garrett Lee

2010-01-01

This slide presentation reviews the NASA program to use expendable lift vehicles (ELVs) to launch nanosatellites for the purpose of enhancing educational research. The Education Launch of Nanosatellite (ELaNa) project, run out of the Launch Services Program is requesting proposals for CubeSat type payload to provide information that will aid or verify NASA Projects designs while providing higher educational research

Moving beyond Compliance: Promoting Research-Based Professional Discretion in the Implementation of the Common Core State Standards in English Language Arts

ERIC Educational Resources Information Center

Woodard, Rebecca; Kline, Sonia

2015-01-01

State- and local-level mandates are currently being implemented to ensure strict compliance to the new national Common Core State Standards for English Language Arts (CCSS for ELA) and related assessments. These standards provide many potential opportunities to improve literacy education nationally and locally. However, the CCSS for ELA will…

Using Multiple Sources of Information in Establishing Text Complexity. Reading Research Report. #11.03

ERIC Educational Resources Information Center

Hiebert, Elfrieda H.

2011-01-01

A focus of the Common Core State Standards/English Language Arts (CCSS/ELA) is that students become increasingly more capable with complex text over their school careers. This focus has redirected attention to the measurement of text complexity. Although CCSS/ELA suggests multiple criteria for this task, the standards offer a single measure of…

Reading Graphically: Examining the Effects of Graphic Novels on the Reading Comprehension of High School Students

ERIC Educational Resources Information Center

Cook, Michael P.

2014-01-01

There have been few empirical studies investigating the uses of graphic novels in education, fewer still in English Language Arts (ELA). As a result, there remain misconceptions about possible uses and potential benefits of graphic texts in ELA classrooms. The purpose of this study was to investigate the effects of graphic novels on the reading…

Making Meaning with Multimedia in Secondary English Language Arts: A Multiple Case Study

ERIC Educational Resources Information Center

Mahoney, Kerrigan Rose

2016-01-01

The purpose of this multiple case study was to learn about how secondary English language arts (ELA) teachers help students to make meaning with multimedia. The study focused on how and why teachers plan and implement meaning-making learning experiences. The cases represent the experiences and perspectives of five ELA teachers who use digital and…

Common Core Standards for High School English Language Arts: A Quick-Start Guide

ERIC Educational Resources Information Center

Kendall, John; Frazee, Dana; Ryan, Susan

2012-01-01

High school teachers and leaders with responsibility for English language arts (ELA) need this handy guide to successfully implement the Common Core in their respective grade levels. Getting a copy for every staff member ensures they know: (1) How grades 11-12 ELA content differs from and builds upon 9-10 standards; (2) How the four strands…

Germination and seedling vigor in Beta vulgaris

USDA-ARS?s Scientific Manuscript database

One former commercial variety, EL-A012206 (ACH185), and the pollen parent for the commercial variety USH20, EL-A015030 (SP7622) were germinated in H2O and 0.3% H2O2. Samples were collected at 0, 3, 6, 12, 18 and 24 hours of treatment for both varieties. RNA was extracted from the tissue and RT-PCR w...

Common Core State Standards for ELA/Literacy and Next Generation Science Standards: Convergences and Discrepancies Using Argument as an Example

ERIC Educational Resources Information Center

Lee, Okhee

2017-01-01

As the Common Core State Standards (CCSS) for English language arts (ELA)/literacy and the Next Generation Science Standards (NGSS) highlight connections across subject areas, convergences and discrepancies come into view. As a prominent example, this article focuses on how the CCSS and the NGSS treat "argument," especially in Grades…

Perceptions about the Influence of Instructional Leadership Practices of Elementary Principals on Teachers' ELA Pedagogical Changes in High-Poverty NYC Elementary Schools

ERIC Educational Resources Information Center

Green, Linda D.

2017-01-01

This quantitative study examined the relationships between instructional leadership practices of elementary school principals in high-poverty schools and changes in teachers' ELA instructional practices. This research sought to identify principals' perceptions about their use of instructional leadership practices and the teaching practices used in…

The Effects of Two Scheduling Formats on Student Achievement in a Suburban High School Setting

ERIC Educational Resources Information Center

Jackson, Kenyada Morton

2013-01-01

Limited studies have been conducted on the relationship between scheduling formats and academic performance of high school students. At the target high school, students underperform on standardized tests in English language arts (ELA) and math. The purpose of this causal comparative quantitative study was to compare the means of ELA and math test…

The pancreatic niche inhibits the effectiveness of sunitinib treatment of pancreatic cancer

PubMed Central

Martínez-Bosch, Neus; Guerrero, Pedro Enrique; Moreno, Mireia; José, Anabel; Iglesias, Mar; Munné-Collado, Jessica; Anta, Héctor; Gibert, Joan; Orozco, Carlos Alberto; Vinaixa, Judith; Fillat, Cristina; Viñals, Francesc; Navarro, Pilar

2016-01-01

Current treatments for pancreatic ductal adenocarcinoma (PDA) are ineffective, making this the 4th leading cause of cancer deaths. Sunitinib is a broad-spectrum inhibitor of tyrosine kinase receptors mostly known for its anti-angiogenic effects. We tested the therapeutic effects of sunitinib in pancreatic cancer using the Ela-myc transgenic mouse model. We showed that Ela-myc pancreatic tumors express PDGFR and VEGFR in blood vessels and epithelial cells, rendering these tumors sensitive to sunitinib by more than only its anti-angiogenic activity. However, sunitinib treatment of Ela-myc mice with either early or advanced tumor progression had no impact on either survival or tumor burden. Further histopathological characterization of these tumors did not reveal differences in necrosis, cell differentiation, angiogenesis, apoptosis or proliferation. In stark contrast, in vitro sunitinib treatment of Ela-myc– derived cell lines showed high sensitivity to the drug, with increased apoptosis and reduced proliferation. Correspondingly, subcutaneous tumors generated from these cell lines completely regressed in vivo after sunitinib treatments. These data point at the pancreatic tumor microenvironment as the most likely barrier preventing sunitinib treatment efficiency in vivo. Combined treatments with drugs that disrupt tumor fibrosis may enhance sunitinib therapeutic effectiveness in pancreatic cancer treatment. PMID:27374084

Earthquake Information System

NASA Technical Reports Server (NTRS)

1991-01-01

IAEMIS (Integrated Automated Emergency Management Information System) is the principal tool of an earthquake preparedness program developed by Martin Marietta and the Mid-America Remote Sensing Center (MARC). It is a two-component set of software, data and procedures to provide information enabling management personnel to make informed decisions in disaster situations. The NASA-developed program ELAS, originally used to analyze Landsat data, provides MARC with a spatially-oriented information management system. Additional MARC projects include land resources management, and development of socioeconomic data.

[Use of COPD-6 Vitalograph in Primary Care as tool for smoking cessation].

PubMed

Antón-García, F; Pruteanu, D F; Correcher-Salvador, E

2016-03-01

To assess the evolution of smoking cessation process after using a COPD-6 Vitalograph in smokers that came to a primary care practice (PCP) during a three year period (March 2011- February 2013). To assess if there are any new COPD diagnoses and to compare the smoking cessation outcomes to those of a specific smoking cessation practice (SSCP) from another healthcare centre. Two devices were used: Vitalograph (electronic device measuring the lung function) and the CO-oximeter, in 176 patients (active search of smokers). tobacco pack-years, tobacco dependence (shortened Fagerström test), CO in exhaled breath (in parts per million-ppm), personal history of COPD or cardiovascular disease (CVD). The patients performed three forced exhalations and the Vitalograph registered the lung function (FEV1, FEV6, FEV1/FEV6) and the estimated lung age (ELA). Patient attitude was assessed (phases: pre-contemplation, contemplation, preparation) before and after the test, informing them of the outcomes. Patient progress in the smoking cessation process was also recorded. A total of 176 smokers were studied in PCP and 33 in SSCP. PCP/SSCP: age: 45.9/51.6 years old (p=042); pack-years 25.5/39.3 (p=0001); patients who quit smoking and used medicines for it 2/9. In PCP: age-ELA 45.9/57.4 (p=0.000). In SSCP: age-ELA 51.6/74.3 (p=000). Smoking habit evolution PCP/SSCP: cessation 24.5%/48.5% (p=004). Difference 24%. CI difference (6.4-42.8%). In PCP new COPD diagnosis in 6 smokers. COPD-6 Vitalograph is a fast and easy to use tool in day-to-day practice. The percentage of smoking cessation is better in SSCP, although a high smoking cessation rate was obtained in PCP (active search). Copyright © 2014 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España, S.L.U. All rights reserved.

Randomized controlled study of excimer laser atherectomy for treatment of femoropopliteal in-stent restenosis: initial results from the EXCITE ISR trial (EXCImer Laser Randomized Controlled Study for Treatment of FemoropopliTEal In-Stent Restenosis).

PubMed

Dippel, Eric J; Makam, Prakash; Kovach, Richard; George, Jon C; Patlola, Raghotham; Metzger, D Christopher; Mena-Hurtado, Carlos; Beasley, Robert; Soukas, Peter; Colon-Hernandez, Pedro J; Stark, Matthew A; Walker, Craig

2015-01-01

The purpose of this study was to evaluate the safety and efficacy of excimer laser atherectomy (ELA) with adjunctive percutaneous transluminal angioplasty (PTA) versus PTA alone for treating patients with chronic peripheral artery disease with femoropopliteal bare nitinol in-stent restenosis (ISR). Femoropopliteal stenting has shown superiority to PTA for lifestyle-limiting claudication and critical limb ischemia, although treating post-stenting artery reobstruction, or ISR, remains challenging. The multicenter, prospective, randomized, controlled EXCITE ISR (EXCImer Laser Randomized Controlled Study for Treatment of FemoropopliTEal In-Stent Restenosis) trial was conducted across 40 U.S. centers. Patients with Rutherford Class 1 to 4 and lesions of target lesion length ≥4 cm, vessel diameter 5 to 7 mm were enrolled and randomly divided into ELA + PTA and PTA groups by a 2:1 ratio. The primary efficacy endpoint was target lesion revascularization (TLR) at 6-month follow up. The primary safety endpoint was major adverse event (death, amputation, or TLR) at 30 days post-procedure. Study enrollment was stopped at 250 patients due to early efficacy demonstrated at a prospectively-specified interim analysis. A total of 169 ELA + PTA subjects (62.7% male; mean age 68.5 ± 9.8 years) and 81 PTA patients (61.7% male; mean age 67.8 ± 10.3 years) were enrolled. Mean lesion length was 19.6 ± 12.0 cm versus 19.3 ± 11.9 cm, and 30.5% versus 36.8% of patients exhibited total occlusion. ELA + PTA subjects demonstrated superior procedural success (93.5% vs. 82.7%; p = 0.01) with significantly fewer procedural complications. ELA + PTA and PTA subject 6-month freedom from TLR was 73.5% versus 51.8% (p < 0.005), and 30-day major adverse event rates were 5.8% versus 20.5% (p < 0.001), respectively. ELA + PTA was associated with a 52% reduction in TLR (hazard ratio: 0.48; 95% confidence interval: 0.31 to 0.74). The EXCITE ISR trial is the first large, prospective, randomized study to demonstrate superiority of ELA + PTA versus PTA alone for treating femoropopliteal ISR. (Randomized Study of Laser and Balloon Angioplasty Versus Balloon Angioplasty to Treat Peripheral In-stent Restenosis [EXCITE ISR]; NCT01330628). Copyright © 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Late Holocene climate change at Goat Lake, Kenai Mountains, south-central Alaska

NASA Astrophysics Data System (ADS)

Daigle, T. A.; Kaufman, D. S.

2006-12-01

Lake sediments, glacier extents, and tree rings were used to reconstruct late Holocene climate changes from Goat Lake in the Kenai Mountains, south-central Alaska (60° 14' N/149° 54' W). Two sediment cores (3.7 and 5.6 m long) were dated with 16 AMS 14C ages and record changes in watershed (organic- matter content) and within-lake (biogenic silica) productivity since ~9500 cal yr BP. Sediment analyses focused on the last 1000 yr; this interval includes a sharp transition from gyttja to inorganic mud at ~1660 AD, which marks the fist time since Pleistocene deglaciation that the north goat outlet glacier (NGO) of the Harding Icefield overtopped the drainage divide at 590 m asl to spill meltwater into Goat Lake. One 14C age of ~1535 AD from a subfossil log in the NGO valley requires ~125 yr for the NGO to thicken 150 m to the elevation of the drainage divide where it remained until ~1930. Since ~1930, the NGO has thinned 150 m and retreated 1.4 km. Equilibrium-line altitudes (ELA) were reconstructed for 12 cirque glaciers nearby Goat Lake based on the accumulation-area ratio (AAR) method following field mapping of ice-marginal features formed during the maximum Little Ice Age (LIA) in the 19th century. Maximum LIA ELA data (AAR = 0.58) were compared with 1950 ELA and yield an average lowering of 50 ± 20 m. Application of the local lapse rate of 0.47°C/100 m indicates an average ablation-season temperature reduction of 0.3°C during the maximum LIA compared to 1950, assuming no change in winter precipitation. A new tree-ring chronology from 27 hemlock trees in the Goat Lake watershed correlates with mean March through August temperature from Kenai airport (r = 0.35) and a 207 yr reconstruction indicates an average temperature reduction of 1.0°C from 1800-1900 compared with 1930-1950. Assuming no change in winter precipitation, then a 1°C cooling should have been associated with an ELA lowering by 200 m. This did not occur, and we suggest that some degree of accumulation-season drying is required to reconcile the summer temperature lowering with the limited reduction in ELA. A reduction in accumulation-season precipitation, in turn, implies a weakening of the Aleutian low pressure system during the LIA.

Younger Dryas equilibrium line altitudes and precipitation patterns in the Alps

NASA Astrophysics Data System (ADS)

Kerschner, Hanns; Moran, Andrew; Ivy-Ochs, Susan

2016-04-01

Moraine systems of the "Egesen Stadial" are widespread and easily identifiable features in the Alps. Absolute dating with terrestrial cosmogenic radionuclides shows that the maximum extent was reached during the early Younger Dryas (YD), probably as a reaction to the intense climatic downturn subsequent to Lateglacial Interstadial. In recent years, several new studies and the availability of high-quality laser-scan hillshades and orthophotos allowed a significant extension of the database of YD glaciers as "palaeoprecipitation gauges" to large hitherto unmapped regions in the Austrian and Swiss Alps. The equilibrium line altitude (ELA) of the glaciers and its lowering relative to the Little Ice Age ELA (dELA) shows a distinct and systematic spatial pattern. Along the northern slope of the Alps, dELAs are usually large (around 400 m and perhaps even more), while dELAs range around 200 m in the well sheltered areas of the central Alps, e.g. in the Engadine and in western Tyrol. Both stochastic glacier-climate models (e.g. Ohmura et al. 1992) and the heat- and mass balance equation (Kuhn 1981) allow the reconstruction of precipitation change under the assumption of a spatially constant summer temperature depression, which in turn can be estimated from biological proxies. This allows to draw the spatial pattern of precipitation change with considerable detail. Precipitation change is clearly controlled by the local relief like high mountain chains, deeply incised and long valleys and mountain passes. Generally the contrast between the northern fringe of the Alps and the interior was more pronounced than today. Climate in the Northern and and Northwestern Alps was rather wet with precipitation totals eventually exceeding modern annual sums. The central Alps received 20 - 30% less precipitation than today, mainly due to reduced winter precipitation. In the southern Alps, still scarce spatial information points to precipitation sums which were approximately similar to modern values. As winter precipitation was probably much smaller than today, seasonal contrasts were more pronounced. In total, the pattern of YD precipitation change is remarkably similar to precipitation patterns caused by westerly and northwesterly cyclonic airflow during the present-day hydrologic winter (October - March). Kerschner, H., G. Kaser, R. Sailer (2000): Alpine Younger Dryas glaciers as paleo-precipitation gauges. Annals of Glaciology 31, 80-84. Kerschner, H. and S. Ivy-Ochs (2007): Palaeoclimate from glaciers: Examples from the Eastern Alps during the Alpine Lateglacial and early Holocene. Global and Planetary Change 60, 58-71.

Early life adversity and adult biological risk profiles.

PubMed

Friedman, Esther M; Karlamangla, Arun S; Gruenewald, Tara L; Koretz, Brandon; Seeman, Teresa E

2015-01-01

To determine whether there is a relationship between early life adversity (ELA) and biological parameters known to predict health risks and to examine the extent to which circumstances in midlife mediate this relationship. We analyzed data on 1180 respondents from the biomarker subsample of the second wave of the National Survey of Midlife Development in the United States. ELA assessments were based on childhood socioeconomic disadvantage (i.e., on welfare, perceived low income, and less educated parents) and other stressors (e.g., parental death, parental divorce, and parental physical abuse). The outcome variable was cumulative allostatic load (AL), a marker of biological risk. We also incorporate information on adult circumstances, including than following: education, social relationships, and health behaviors. Childhood socioeconomic adversity and physical abuse were associated with increased AL (B = 0.094, standard error = 0.041, and B = 0.263, standard error = 0.091 respectively), with nonsignificant associations for parental divorce and death with AL. Adult education mediated the relationship between socioeconomic ELA and cumulative AL to the point of nonsignificance, with this factor alone explaining nearly 40% of the relationship. The association between childhood physical abuse and AL remained even after adjusting for adult educational attainments, social relationships, and health behaviors. These associations were most pronounced for secondary stress systems, including inflammation, cardiovascular function, and lipid metabolism. The physiological consequences of early life socioeconomic adversity are attenuated by achieving high levels of schooling later on. The adverse consequences of childhood physical abuse, on the other hand, persist in multivariable-adjusted analysis.

A "Common" Vision of Instruction? An Analysis of English/Language Arts Professional Development Materials Related to the Common Core State Standards

ERIC Educational Resources Information Center

Hodge, Emily; Benko, Susanna L.

2014-01-01

The purpose of this article is to describe the stances put forward by a selection of professional development resources interpreting the Common Core State Standards for English Language Arts (ELA) teachers, and to analyse where these resources stand in relation to research in ELA. Specifically, we analyse resources written by English educators…

The English Language Arts (ELA) Exam and Academic Achievement: Is There a Relationship? Predictive Validity of Statewide Measures

ERIC Educational Resources Information Center

Mazza, Lynn

2010-01-01

The No Child Left Behind Act is a mandate from the federal government for education to increase student performance and school accountability. As a result of this mandate, many states have issued the use of high-stakes standardized tests as a means of monitoring schools' accountability. New York State administers the English Language Arts (ELA)…

Reconstruction and paleoclimatic significance of Late Pleistocene niche glaciation at Mt Aston, Tararua Range, North Island, New Zealand

NASA Astrophysics Data System (ADS)

Brook, Martin

2017-04-01

Evidence for the timing of inter-hemispheric climate fluctuations during the Pleistocene is important, with reconstructed mountain glacier extents routinely used as a proxy for climate. While valley glaciers extended out from an ice sheet centred on New Zealand's Southern Alps during Pleistocene climate cooling to below present-day sea level, evidence of former glacial activity on the North Island of New Zealand is rare, in comparison. A newly-identified glaciated site is Mt Aston, an isolated cirque-like basin within the Tararua Range on New Zealand's North Island. Previously published cosmogenic isotope ages and paleo-glacier reconstructions of a 3 km-long valley glacier 30 km to the north show that paleo-equilibrium line altitudes (ELAs) increased northwards across New Zealand during the regional last glacial maximum (LGM). Hence, at this latitude (41˚ 00' S), only topography >1300 m above present day sea-level was of feasible elevation to intersect the prevailing south-westerly airflow and to allow niche glaciers to form. In the basin below Mt Aston, a c. 0.38 km2 cirque glacier existed with ELA of c. 1290 ± 10 m above present-day sea level. This paleo-ELA closely approximates the extrapolated ELA trend surface for the regional LGM. The mean glacier thickness of 35 m gives a maximum basal shear stress of c. 102 kPa-1, with a mean January temperature at the ELA of c. 5.5 ˚ C. It is well-established that present-day glaciers in New Zealand are particularly sensitive to climate change, manifested by glacial advances and retreats in response to simple mass balance dynamics. Consistent with this, the paleo-glacier reconstruction implies that rather than simple temperature decreases driving paleo-ELA depression, changes in south-westerly airflow over New Zealand, bringing moisture-laden but cool air, maximized snowfall and minimised winter melt. The corollary is that (1) patterns of Pleistocene glacier fluctuations may be interpreted as responses, in-part, to precipitation-driven changes, and (2) the extent of LGM glaciation on New Zealand's North Island was probably more extensive than previously assumed.

Global snowline and mountain topography: a contrasted view

NASA Astrophysics Data System (ADS)

Champagnac, Jean-Daniel; Herman, Frédéric; Valla, Pierre

2013-04-01

The examination of the relationship between Earth's topography and present and past climate (i.e., long-term elevation of glaciers Equilibrium Line Altitude) reveals that the elevation of mountain ranges may be limited or controlled by glaciations (e.g. Porter, 1989). This is of prime importance, because glacial condition would lead to a limit the mountain development, hence the accumulation of gravitational energy and prevent the development of further glacial conditions as well as setting the erosion in (peri)glacial environments. In this study, we examine the relationships between topography and the global Equilibrium Line Altitude of alpine glaciers around the world (~ long term snowline, i.e. the altitude where the ice mass balance is null). This analysis reinforce a global study previously published (Champagnac et al., 2012), and provide a much finer view of the climate-topography-tectonics relationships. Specifically, two main observations can be drawn: 1) The distance between the (averaged and maximum) topography, and the ELA decreases pole ward the poles, and even become reversed (mean elevation above to ELA) at high latitude. Correlatively, the elevation of very large portion of land at mid-latitude cannot be related to glaciations, simply because it was never glaciated (large distance between topography and long-term mean ELA). The maximum distance between the ELA and the topography is greater close to the equator and decreases poleward. In absence of glacial and periglacial erosion, this trend cannot have its origin in glacial and periglacial processes. Moreover, the ELA elevation shows a significant (1000~1500m) depression in the intertropical zone. This depression of the ELA is not reflected at all in the topography 2) The distribution of relief on Earth, if normalized by the mean elevation of mountain ranges (as a proxy for available space to create relief, see Champagnac et al., 2012 for details) shows a latitudinal band of greater relief between ~40 and ~60° (or between ELA of ~500m to ~2500m a.s.l.). This mid-latitude relatively greater relief challenges the straightforward relationship between glaciations, erosion and topography. Oppositely, it suggests that glacier may be more efficient agent in temperate area, with an important amplitude between glacial and interglacial climate. This is consistent with the view of a very variable glacier erodibility that can erode and protect the landscape, as well as with studies documenting a bimodal location of the preferred glacial erosion, at relatively high elevation (around the long-term ELA), and at much lower elevation (close to the glacial maximum lower reaches), thanks to efficient water lubrication of the glacier bases that greatly enhance the sliding velocity (Herman et al., 2011). These findings show that the relation between the mountain topography and the long term snowline is not as straightforward as previously proposed (e.g. Egholm et al., 2009) . Beside the role of tectonic forcing highlighted by several authors (e.g. Pedersen et al., 2010;Spotila and Berger, 2010),, the importance of the glacial erosion appears to be crucial at mid latitude, but more complex at both high and low latitude. Moreover, the relief at mid latitude appears to be higher, hence suggesting a positive correlation between relief and topographic control of glacier on the landscape Champagnac, J.-D., Molnar, P., Sue, C., and Herman, F.: Tectonics, Climate, and Mountain Topography, Journal of Geophysical Research B: Solid Earth, 117, doi:10.1029/2011JB008348, 2012. Egholm, D. L., Nielsen, S. B., Pedersen, V. K., and Lesemann, J. E.: Glacial effects limiting mountain height, Nature, 460, 884-888, 2009. Herman, F., Beaud, F., Champagnac, J.-D., Lemieux, J.-M., and Sternai, P.: Glacial hydrology and erosion patterns: A mechanism for carving glacial valleys, Earth and Planetary Science Letters, 310, 498-508, 2011. Pedersen, V. K., Egholm, D. L., and Nielsen, S. B.: Alpine glacial topography and the rate of rock column uplift: a global perspective, Geomorphology, 122, 129-139, 10.1016/j.geomorph.2010.06.005, 2010. Porter, S. C.: Some geological implications of average Quaternary glacial conditions., Quaternary Research, 32, 245-261, 1989. Spotila, J. A., and Berger, A. L.: Exhumation at orogenic indentor corners under long-term glacial conditions: Example of the St. Elias orogen, Southern Alaska, Tectonophysics, 490, 241-256, doi:10.1016/j.tecto.2010.05.015, 2010.

Equilibrium line altitudes and climate during the Late Holocene glacial maximum in the Andes

NASA Astrophysics Data System (ADS)

Sagredo, E. A.; Lowell, T. V.; Kelly, M. A.; Aravena, J.

2012-12-01

Documenting the spatial and temporal pattern of climate change associated with widespread glacial fluctuations during Late Holocene time is critical for understanding the mechanisms underlying these climatic/glacial events. Here, we estimate the change in equilibrium line altitudes (ELAs) associated with the most prominent glacial advance during the last millennium for four alpine glaciers in different climatic regimes in the Andes. We reconstruct scenarios of the climatic conditions (temperature and precipitation anomalies) that accommodate the ELA depressions. The glaciers studied are an unnamed glacier in the Cordillera Vilcanota (13°S), Tapado glacier (30°S), Cipreses glacier (34°S) and Tranquilo glacier (47°S). Results from the combined geomorphic analysis and application of a surface energy and mass balance model suggest that there is not a unique combination of temperature and precipitation conditions that accommodates the ELA change recorded since the Late Holocene maximum at the four sites. Assuming no change in precipitation, the ELA depressions could be explained by a cooling (with respect to present-day values) of at least -0.7°C at Cordillera Vilcanota, -1.0°C at Tapado glacier, -0.5°C at Cipreses glacier and -1.3°C at Tranquilo glacier. In contrast, assuming no change in temperature, the ELA depressions could be explained by an increase in the precipitation of at least 0.51 m (63% of the annual precipitation) at Cordillera Vilcanota, 0.33 m (95%) at Tapado glacier, 0.17 m (21%) at Cipreses glacier and 0.68 m (62%) at Tranquilo glacier. Our results serve as targets to test predictions from models of global climate dynamics for the last millennium and contribute to the understanding of the mechanisms underlying the Late Holocene glacial fluctuations.

Early-Life Adversity Interacts with FKBP5 Genotypes: Altered Working Memory and Cardiac Stress Reactivity in the Oklahoma Family Health Patterns Project.

PubMed

Lovallo, William R; Enoch, Mary-Anne; Acheson, Ashley; Cohoon, Andrew J; Sorocco, Kristen H; Hodgkinson, Colin A; Vincent, Andrea S; Goldman, David

2016-06-01

Exposure to stress during critical periods of development can have adverse effects on adult health behaviors, and genetic vulnerabilities may enhance these stress effects. We carried out an exploratory examination of psychological, physiological, and behavioral characteristics of 252 healthy young adults for the impact of early-life adversity (ELA) in relation to the G-to-A single nucleotide polymorphism (SNP), rs9296158, of the FKBP5 gene. FKBP5 is a molecular cochaperone that contributes to the functional status of the glucocorticoid receptor (GR) and to the quality of corticosteroid signaling. FKBP5 expression is upregulated by cortisol exposure during stressful episodes, with greater upregulation seen in A-allele carriers. As such, FKBP5 expression and GR function may be environmentally sensitive in A-allele carriers and therefore suitable for the study of gene-by-environment (G × E) interactions. Compared with FKBP5, GG homozygotes (N=118), A-allele carriers (N = 132) without psychiatric morbidity had progressively worse performance on the Stroop color-word task with increasing levels of ELA exposure (Genotype × ELA, F=5.14, P=0.007), indicating a G × E interaction on working memory in early adulthood. In addition, heart rate response to mental stress was diminished overall in AA/AG-allele carriers (F=5.15, P=0.024). Diminished working memory and attenuated autonomic responses to stress are both associated with risk for alcoholism and other substance use disorders. The present data suggest that FKBP5 in the GR pathway may be a point of vulnerability to ELA, as seen in this group of non-traumatized young adults. FKBP5 is accordingly a potential target for more extensive studies of the impact of ELA on health and health behaviors in adulthood.

ELA-DRA polymorphisms are not associated with Equine Arteritis Virus infection in horses from Argentina.

PubMed

Kalemkerian, P B; Metz, G E; Peral-Garcia, P; Echeverria, M G; Giovambattista, G; Díaz, S

2012-12-01

Polymorphisms at Major Histocompatibility Complex (MHC) genes have been associated with resistance/susceptibility to infectious diseases in domestic animals. The aim of this investigation was to evaluate whether polymorphisms of the DRA gene the Equine Lymphocyte Antigen is associated with susceptibility to Equine Arteritis Virus (EAV) infection in horses in Argentina. The equine DRA gene was screened for polymorphisms using Pyrosequencing® Technology which allowed the detection of three ELA-DRA exon 2 alleles. Neither allele frequencies nor genotypic differentiation exhibited any statistically significant (P-values=0.788 and 0.745) differences between the EAV-infected and no-infected horses. Fisher's exact test and OR calculations did not show any significant association. As a consequence, no association could be established between the serological condition and ELA-DRA. Copyright © 2012 Elsevier Ltd. All rights reserved.

Interpreting forest and grassland biome productivity utilizing nested scales of image resolution and biogeographical analysis

NASA Technical Reports Server (NTRS)

Iverson, L. R.; Olson, J. S.; Risser, P. G.; Treworgy, C.; Frank, T.; Cook, E.; Ke, Y.

1986-01-01

Data acquisition, initial site characterization, image and geographic information methods available, and brief evaluations of first-year for NASA's Thematic Mapper (TM) working group are presented. The TM and other spectral data are examined in order to relate local, intensive ecosystem research findings to estimates of carbon cycling rates over wide geographic regions. The effort is to span environments ranging from dry to moist climates and from good to poor site quality using the TM capability, with and without the inclusion of geographic information system (GIS) data, and thus to interpret the local spatial pattern of factors conditioning biomass or productivity. Twenty-eight TM data sets were acquired, archived, and evaluated. The ERDAS image processing and GIS system were installed on the microcomputer (PC-AT) and its capabilities are being investigated. The TM coverage of seven study areas were exported via ELAS software on the Prime to the ERDAS system. Statistical analysis procedures to be used on the spectral data are being identified.

Solar and Volcanic Modulation of Little Ice Age Climate in the Tropical Andes, Venezuela

NASA Astrophysics Data System (ADS)

Polissar, P. J.; Abbott, M. B.; Wolfe, A. P.; Rull, V.; Bezada, M.

2004-12-01

The underlying causes of late-Holocene climate variability in the tropics are incompletely understood. Here, we report a 1500-year reconstruction of climate history in the Venezuelan Andes using lake sediment records from four sites. This reconstruction is based upon accelerator mass spectrometry (AMS) radiocarbon and Pb-210 dating, sedimentology, magnetic susceptibility, geochemistry, pollen and stable isotope (C, N) measurements. In the Laguna Mucubaji watershed four distinct glacial advances occurred between 1250 and 1810 A.D. The earliest advance began during an extended period of higher global volcanic activity. The subsequent three advances were coincident with minima in solar activity (reconstructed from Be-10 and C-14 records). The Mucubají glacial activity in the Venezuelan Andes coincides with other records of Little Ice Age (LIA) glacial advances in S. America. Comparison of modern glacier equilibrium line altitudes (ELAs) in Venezuela with the Mucubaji LIA glacier ELA indicates an ELA depression of at least 300 m. Both a decline in temperature and increase in precipitation are required to explain the ELA depression. The precipitation increase is supported by increased catchment erosion recorded in L. Blanca sediments. Pollen records from two sites in the Venezuelan Andes also indicate wetter and colder conditions during the LIA.

Fluctuating snow line altitudes in the Hunza basin (Karakoram) using Landsat OLI imagery

NASA Astrophysics Data System (ADS)

Racoviteanu, Adina; Rittger, Karl; Brodzik, Mary J.; Painter, Thomas H.; Armstrong, Richard

2016-04-01

Snowline altitudes (SLAs) on glacier surfaces are needed for separating snow and ice as input for melt models. When measured at the end of the ablation season, SLAs are used for inferring stable-state glacier equilibrium line altitudes (ELAs). Direct measurements of snowlines are rarely possible particularly in remote, high altitude glacierized terrain, but remote sensing data can be used to separate these snow and ice surfaces. Snow lines are commonly visible on optical satellite images acquired at the end of the ablation season if the images are contrasted enough, and are manually digitized on screen using various satellite band combinations for visual interpretation, which is a time-consuming, subjective process. Here we use Landsat OLI imagery at 30 m resolution to estimate glacier SLAs for a subset of the Hunza basin in the Upper Indus in the Karakoram. Clean glacier ice surfaces are delineated using a standardized semi-automated band ratio algorithm with image segmentation. Within the glacier surface, snow and ice are separated using supervised classification schemes based on regions of interest, and glacier SLAs are extracted on the basis of these areas. SLAs are compared with estimates from a new automated method that relies on fractional snow covered area rather than on band ratio algorithms for delineating clean glacier ice surfaces, and on grain size (instead of supervised classification) for separating snow from glacier ice on the glacier surface. The two methods produce comparable snow/ice outputs. The fSCA-derived glacierized areas are slightly larger than the band ratio estimates. Some of the additional area is the result of better detection in shadows from spectral mixture analysis (true positive) while the rest is shallow water, which is spectrally similar to snow/ice (false positive). On the glacier surface, a thresholding the snow grain size image (grain size > 500μm) results in similar glacier ice areas derived from the supervised classification, but there is noise (snow) on edges of dirty ice/ moraines at the glacier termini and around rock outcrops on the glacier surface. Neither of the two methods distinguishes the debris-covered ice, so these were mapped separately using a combination of topographic indices (slope, terrain curvature), along with remote sensing surface temperature and texture data. Using average elevation of snow and ice areas, we calculate an ELA of 5260 m for 2013. We construct yearly time series of the ELAs around the centerlines of selected glaciers in the Hunza for the period 2000 - 2014 using Landsat imagery. We explore spatial trends in glacier ELAs within the region, as well as relationships between ELA and topographic characteristics extracted on a glacier-by-glacier basis from a digital elevation model.

Origin of the energy level alignment at organic/organic interfaces: The role of structural defects

NASA Astrophysics Data System (ADS)

Bussolotti, Fabio; Yang, Jinpeng; Hinderhofer, Alexander; Huang, Yuli; Chen, Wei; Kera, Satoshi; Wee, Andrew T. S.; Ueno, Nobuo

2014-03-01

In this paper, the electronic properties of as-deposited and N2-exposedCuPc/F16CuPc interface, a prototype system for organic photovoltaic applications, are investigated by using ultralow background, high-sensitivity photoemission spectroscopy. It is found that (i) N2 exposure significantly modifies the energy level alignment (ELA) at the interface between CuPc and F16CuPc layer and (ii) the direction of the N2-induced energy level shift of the CuPc depends on the position of the Fermi level (EF) in the CuPc highest occupied molecular orbital-lowest unoccupied molecular orbital gap of the as-deposited film. These observations are related to the changes in the density of gap states (DOGS) produced by structural imperfections in the molecular packing geometry, as introduced by the N2 penetration into the CuPc layer. This result demonstrates the key role of structure-induced DOGS in controlling the ELA at organic/organic interfaces.

Glacial morphology in the Chinese Pamir: Connections among climate, erosion, topography, lithology and exhumation

NASA Astrophysics Data System (ADS)

Schoenbohm, Lindsay M.; Chen, Jie; Stutz, Jamey; Sobel, Edward R.; Thiede, Rasmus C.; Kirby, Benjamin; Strecker, Manfred R.

2014-09-01

Modification of the landscape by glacial erosion reflects the dynamic interplay of climate through temperature, precipitation, and prevailing wind direction, and tectonics through rock uplift and exhumation rate, lithology, and range and fault geometry. We investigate these relationships in the northeast Pamir Mountains using mapping and dating of moraines and terraces to determine the glacial history. We analyze modern glacial morphology to determine glacier area, spacing, headwall relief, debris cover, and equilibrium line altitude (ELA) using the area x altitude balance ratio (AABR), toe-to-headwall altitude ratio (THAR) and toe-to-summit altitude method (TSAM) for 156 glaciers and compare this to lithologic, tectonic, and climatic data. We observe a pronounced asymmetry in glacial ELA, area, debris cover, and headwall relief that we interpret to reflect both structural and climatic control: glaciers on the downwind (eastern) side of the range are larger, more debris covered, have steeper headwalls, and tend to erode headward, truncating the smaller glaciers of the upwind, fault-controlled side of the range. We explain this by the transfer of moisture deep into the range as wind-blown or avalanched snow and by limitations imposed on glacial area on the upwind side of the range by the geometry of the Kongur extensional system (KES). The correspondence between rapid exhumation along the KES and maxima in glacier debris cover and headwall relief and minimums in all measures of ELA suggest that taller glacier headwalls develop in a response to more rapid exhumation rates. However, we find that glaciers in the Muji valley did not extend beyond the range front until at least 43 ka, in contrast to extensive glaciation since 300 ka in the south around the high peaks, a pattern which does not clearly reflect uplift rate. Instead, the difference in glacial history and the presence of large peaks (Muztagh Ata and Kongur Shan) with flanking glaciers likely reflects lithologic control (i.e., the location of crustal gneiss domes) and the formation of peaks that rise above the ELA and escape the glacial buzzsaw.

Writing to the Common Core: Teachers' Responses to Changes in Standards and Assessments for Writing in Elementary Schools

ERIC Educational Resources Information Center

Wilcox, Kristen Campbell; Jeffery, Jill V.; Gardner-Bixler, Andrea

2016-01-01

This multiple case study investigated how the Common Core State Standards (CCSS) for writing and teacher evaluation system based in part on CCSS assessments might be influencing writing instruction in elementary schools. The sample included nine schools: Six achieved above-predicted performance on English Language Arts (ELA) as well as prior ELA…

Avoidable Software Procurements

DTIC Science & Technology

2012-09-01

software license, software usage, ELA, Software as a Service , SaaS , Software Asset...PaaS Platform as a Service SaaS Software as a Service SAM Software Asset Management SMS System Management Server SEWP Solutions for Enterprise Wide...delivery of full Cloud Services , we will see the transition of the Cloud Computing service model from Iaas to SaaS , or Software as a Service . Software

Equilibrium Line Altitudes and paleotemperature reconstructions from Nevado Hualcán (9°S) and Nevado Coropuna (15°S), Tropical Andes (Peru).

NASA Astrophysics Data System (ADS)

Úbeda, J.; Giráldez, C.; Palacios, D.

2012-04-01

We have reconstructed the Equilibrium Line Altitude (ELA) in seven valleys on the SW slope of Nevado Hualcán (9°S, 77°W; 6122 m asl) and on the SE slope of Nevado Coropuna (15°S, 72°W; 6377masl) using the Area x Altitude Balance Ratio method (Osmaston 2005). We have also deduced the paleotemperatures using the following equation: ΔT=ATLR•ΔELA; being ΔT (°C) the paleotemperature depression; ATLR (°C/m) the Atmospheric Temperature Lapse Rate; and ΔELA (m) the ELA depression. The ATLR for Coropuna was deduced through the use of data loggers. For Hualcán we used the value ATLR =0.0065°C/m, valid for the tropics (Kaser and Osmaston, 2002). We obtained the following results: 1) Hualcán: a) ELAs: 5124m (2003); 5018m (1962); 4994m during the Little Ice Age (LIA); and 4652m during the last studied maximum advance considered to be the Younger Dryas (YD, ~13-11ka) by correlation with nearby mountains (Glasser et al., 2009). b) ΔELAs: 106m (1962); 130m (LIA); and 199m (YD). c) ΔT: -0.69°C (1962); -0.85°C (LIA); -3.07°C (YD). 2) Coropuna: a) ELAs: 5862m (2007); 5853m (1986); 5787m (1955); 5776 (LIA); and 4951m in the 13-1136Cl ka phase (Ubeda, 2011). b) ΔELA: 9m (1986); 66m (1955); 86m (LIA); and 911m in 13-1136Cl ka. C) ΔT: -0.20°C (1986); -0.71°C (1955); and -7.65°C (13-1136Cl ka). The values ΔT during LIA in Hualcán and Coropuna (0.85 and 0.72°C) are consistent with the global warming considered to be 0,74°C between 1906 and 2005 (IPCC, 2007). During the mid XXth century and the LIA, ΔT is higher in Hualcán (0.69°C and 0.85°C) than in Coropuna (0.55°C and 0.72°C), with a regional gradient of -0.02°C per degree of latitude (°C/°). However, during the YD (13-1136Cl ka), ΔT was higher in Coropuna (7.65°C) than in Hualcán (3.07°C), with a gradient of 0.76°C/°. Although other evidences exist of a pantropical cooling of >5°C during the last glaciation, in Coropuna this cooling was strengthened by the retro-alimentation of its glacial system which in 13-1136Cl ka had a surface of >400 km2 (Ubeda, 2011). Glasser, N.F., Clemmens, S., Schnabel, C., Fenton, C.R. and McHargue, L., 2009. Tropical glacier fluctuations in the Cordillera Blanca, Peru between 12.5 and 7.6 ka from cosmogenic 10Be dating. Quaternary Science Reviews, 28: 3448-3458. IPCC, 2007: Climate Change 2007: Synthesis Report. Contribution of Working Groups I, II and III to the Fourth Assessment Report of the Intergovernmental Panel on Climate Change [Core Writing Team, Pachauri, R.K and Reisinger, A. (eds.)]. IPCC, Geneva, Switzerland, 104 pp. Kaser, G. and Osmaston, H., 2002. Tropical Glaciers. International Hydrology Series. Cambridge University Press, Cambridge (U.K.), 207 pp. Osmaston, H., 2005. Estimates of glacier equilibrium line altitudes by the Area x Altitude, the Area x Altitude Balance Ratio and the Area x Altitude Balance Index methods and their validation. Quaternary International, 22-31: 138-139. Úbeda, J., 2011. El impacto del cambio climático en los glaciares del complejo volcánico Nevado Coropuna (cordillera occidental de los Andes, Sur del Perú). PhD Thesis. Universidad Complutense de Madrid, (Spain), 558 pp. Available online: http://eprints.ucm.es/12076/ Research funded by CGL2009-7343 project, Government of Spain.

[Cell-ELA-based determination of binding affinity of DNA aptamer against U87-EGFRvIII cell].

PubMed

Tan, Yan; Liang, Huiyu; Wu, Xidong; Gao, Yubo; Zhang, Xingmei

2013-05-01

A15, a DNA aptamer with binding specificity for U87 glioma cells stably overexpressing the epidermal growth factor receptor variant III (U87-EGFRvIII), was generated by cell systematic evolution of ligands by exponential enrichment (cell-SELEX) using a random nucleotide library. Subsequently, we established a cell enzyme-linked assay (cell-ELA) to detect the affinity of A15 compared to an EGFR antibody. We used A15 as a detection probe and cultured U87-EGFRvIII cells as targets. Our data indicate that the equilibrium dissociation constants (K(d)) for A15 were below 100 nmol/L and had similar affinity compared to an EGFR antibody for U87-EGFRvIII. We demonstrated that the cell-ELA was a useful method to determine the equilibrium dissociation constants (K(d)) of aptamers generated by cell-SELEX.

Glacier-derived climate for the Younger Dryas in Europe

NASA Astrophysics Data System (ADS)

Pellitero, Ramon; Rea, Brice R.; Spagnolo, Matteo; Hughes, Philip; Braithwaite, Roger; Renssen, Hans; Ivy-Ochs, Susan; Ribolini, Adriano; Bakke, Jostein; Lukas, Sven

2016-04-01

We have reconstructed and calculated the glacier equilibrium line altitudes (ELA) for 120 Younger Dryas palaeoglaciers from Morocco in the south to Svalbard in the north and from Ireland in the west to Turkey in the east. The chronology of these landform were checked and, when derived from cosmogenic dates, these were recalculated based on newer production rates. Frontal moraines/limits for the palaeoglaciers were used to reconstruct palaeoglacier extent by using a GIS tool which implements a discretised solution for the assumption of perfect-plasticity ice rheology for a single flowline and extents this out to a 3D ice surface. From the resulting equilibrium profile, palaeoglaciers palaeo-ELAs were calculated using another GIS tool. Where several glaciers were reconstructed in a region, a single ELA value was generated following the methodology of Osmaston (2005). In order to utilise these ELAs for quantitative palaeo-precipitation reconstructions an independent regional temperature analysis was undertaken. A database of 121 sites was compiled where the temperature was determined from palaeoproxies other than glaciers (e.g. pollen, diatoms, choleoptera, chironimids…) in both terrestrial and offshore environments. These proxy data provides estimates of average annual, summer and winter temperatures. These data were merged and interpolated to generate maps of average temperature for the warmest and coldest months and annual average temperature. From these maps the temperature at the ELA was obtained using a lapse rate of 0.65°C/100m. Using the ELA temperature range and summer maximum in a degree-day model allows determination of the potential melt which can be taken as equivalent to precipitation given the assumption a glacier is in equilibrium with climate. Results show that during the coldest part of the Younger Dryas precipitation was high in the British Isles, the NW of the Iberian Peninsula and the Vosges. There is a general trend for declining precipitation to the east with some regional exceptions. Local rain shadow effects can be seen in NW Scotland, NW Iberian Peninsula, the Balkans and the Alps. Precipitation is lowest for glaciers in N Norway, which appear to have had their Younger Dryas maxima later in the stadial. This is interpreted to be the result of limited precipitation north of the polar front due to the presence of a near permanent sea ice cover.

The Probability of a General Education Student Placed in a Co-Taught Inclusive Classroom of Passing the 2014 New York State ELA and Mathematics Assessment in Grades 6-8

ERIC Educational Resources Information Center

St. John, Michael M.; Babo, Gerard

2015-01-01

This study examined the influence of placement in a co-taught inclusive classroom on the academic achievement of general education students in grades 6-8 in a suburban New York school district on the 2014 New York State ELA and Mathematics Assessments. Propensity Score Matching (PSM) was utilized for sample selection in order to simulate a more…

KSC-2015-1262

NASA Image and Video Library

2015-01-31

VANDENBERG AIR FORCE BASE, Calif. – Scott Higginbotham, NASA mission manager for Educational Launch of Nanosatellites, or ELaNa-X, at the Kennedy Space Center in Florida, participates in a news conference at Vandenberg Air Force Base in California, following NASA's successful launch of the Soil Moisture Active Passive satellite, or SMAP, on its mission to study the Earth's soil moisture. To learn more about ELaNa, visit http://www.nasa.gov/mission_pages/smallsats/elana. Photo credit: NASA/Kim Shiflett

Peptide-binding motifs of two common equine class I MHC molecules in Thoroughbred horses.

PubMed

Bergmann, Tobias; Lindvall, Mikaela; Moore, Erin; Moore, Eugene; Sidney, John; Miller, Donald; Tallmadge, Rebecca L; Myers, Paisley T; Malaker, Stacy A; Shabanowitz, Jeffrey; Osterrieder, Nikolaus; Peters, Bjoern; Hunt, Donald F; Antczak, Douglas F; Sette, Alessandro

2017-05-01

Quantitative peptide-binding motifs of MHC class I alleles provide a valuable tool to efficiently identify putative T cell epitopes. Detailed information on equine MHC class I alleles is still very limited, and to date, only a single equine MHC class I allele, Eqca-1*00101 (ELA-A3 haplotype), has been characterized. The present study extends the number of characterized ELA class I specificities in two additional haplotypes found commonly in the Thoroughbred breed. Accordingly, we here report quantitative binding motifs for the ELA-A2 allele Eqca-16*00101 and the ELA-A9 allele Eqca-1*00201. Utilizing analyses of endogenously bound and eluted ligands and the screening of positional scanning combinatorial libraries, detailed and quantitative peptide-binding motifs were derived for both alleles. Eqca-16*00101 preferentially binds peptides with aliphatic/hydrophobic residues in position 2 and at the C-terminus, and Eqca-1*00201 has a preference for peptides with arginine in position 2 and hydrophobic/aliphatic residues at the C-terminus. Interestingly, the Eqca-16*00101 motif resembles that of the human HLA A02-supertype, while the Eqca-1*00201 motif resembles that of the HLA B27-supertype and two macaque class I alleles. It is expected that the identified motifs will facilitate the selection of candidate epitopes for the study of immune responses in horses.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fujii, Mami N., E-mail: f-mami@ms.naist.jp; Ishikawa, Yasuaki; Bermundo, Juan Paolo Soria

In a previous work, we reported the high field effect mobility of ZnO-doped In{sub 2}O{sub 3} (IZO) thin film transistors (TFTs) irradiated by excimer laser annealing (ELA) [M. Fujii et al., Appl. Phys. Lett. 102, 122107 (2013)]. However, a deeper understanding of the effect of ELA on the IZO film characteristics based on crystallinity, carrier concentrations, and optical properties is needed to control localized carrier concentrations for fabricating self-aligned structures in the same oxide film and to adequately explain the physical characteristics. In the case of as-deposited IZO film used as the channel, a high carrier concentration due to amore » high density of oxygen vacancies was observed; such a film does not show the required TFT characteristics but can act as a conductive film. We achieved a decrease in the carrier concentration of IZO films by crystallization using ELA. This means that ELA can form localized conductive or semi-conductive areas on the IZO film. We confirmed that the reason for the carrier concentration decrease was the decrease of oxygen-deficient regions and film crystallization. The annealed IZO films showed nano-crystalline phase, and the temperature at the substrate was substantially less than the temperature limit for flexible films such as plastic, which is 50°C. This paves the way for the formation of self-aligned structures and separately formed conductive and semi-conductive regions in the same oxide film.« less

The Predictive Validity of Interim Assessment Scores Based on the Full-Information Bifactor Model for the Prediction of End-of-Grade Test Performance

ERIC Educational Resources Information Center

Immekus, Jason C.; Atitya, Ben

2016-01-01

Interim tests are a central component of district-wide assessment systems, yet their technical quality to guide decisions (e.g., instructional) has been repeatedly questioned. In response, the study purpose was to investigate the validity of a series of English Language Arts (ELA) interim assessments in terms of dimensionality and prediction of…

Evaluation of Little Ice Age cooling in Western Central Andes, suggested by paleoELAs, in contrast with global warming since late 19th century deduced from instrumental records

NASA Astrophysics Data System (ADS)

Ubeda, Jose; Palacios, David; Campos, Néstor; Giraldez, Claudia; García, Eduardo; Quiros, Tatiana

2015-04-01

This paper attempts to evaluate climate cooling (°C) during the glacial expansion phases using the product GTV•ΔELA, where GTV is the vertical air temperature gradient (°C/m) and ΔELA (m) the difference in level observed between the Equilibrium Line Altitude (ELA) reconstructions for current and past glaciers. With this aim the Area x Altitude Balance Ratio-(AABR) method was used to produce reconstructions of present ELAs (2002-2010) and paleoELAs corresponding to the last glacier advance phase. The reconstructions were produced in three study areas located along a N-S transect of the western cordillera in the Central Andes: the south-western sector of the Nevado Hualcán (9°S, 77°W; Giráldez 2011); the southern slope of the Cordillera Pariaqaqa (12°S, 76°W; Quirós, 2013) and the NW, NE, SE and SW quadrants of the Nevado Coropuna (16°S, 72°W; García 2013; Úbeda 2011; Campos, 2012). The three mountains exceed 6000 m altitude, their summit areas are covered by glaciers, and on their slopes there are existing well-conserved moraines deposited by the last advances near the present front of the ice masses. Although there are no absolute dates to confirm this hypothesis, it has been assumed that the last glacial advances occurred during the Little Ice Age (LIA), which the oxygen isotopes of the Nevado Huascarán (9°S, 77°W) date to the period 1500-1890. For the Hualcán and Pariaqaqa the mean global value of the Earth's GTV (6.5°C/km) was used, considered valid for the Tropics. On the Coropuna a GTV=8.4°C/km was used, based on high resolution sensors installed in situ since 2007 (Úbeda 2011). This gradient is approaching the upper limit of the dry adiabatic gradient (9.8°C/km), as the Coropuna region is more arid than the other case study areas. The climate cooling estimates deduced from the product GTV•ΔELA were compared with the global warming shown by the 1880-2012 series, ΔT=0.85°C, and 1850/1900-2003/2012, ΔT=0.78°C. The differences are small (averaging 0.05 and 0.12 °C) suggesting that the product GTV•ΔELA may be a good indicator of climate cooling during glacial expansion phases. However, the role played by precipitation has not yet been determined, and this will be examined in future research. Campos (2012). Glacier evolution in the South West slope of Nevado Coropuna (Cordillera Ampato, Peru). Master Thesis. Universidad Complutense de Madrid (Spain), pp. 55. http://eprints.ucm.es/19889/. García, E. (2013). Evolución glaciar del cuadrante noroeste del Nevado Coropuna. Master Thesis. Universidad Complutense de Madrid (Spain), p. 50. http://eprints.ucm.es/23671/. Giráldez, C. (2011). Glacier evolution in the South West slope of Nevado Hualcán (Cordillera Blanca, Peru). Master Thesis. Universidad Complutense de Madrid (Spain), p. 125. http://eprints.ucm.es/14013/. IPCC (2013). Climate Change 2013. The Physical Science Basis. Working Group I Contribution to the Fifth Assessment Report of the Intergovernmental Panel on Climate Change. Cambridge (UK) y New York (USA), 1535 pp. Research funded by Cryocrisis (CGL2012-35858) and www.cryoperu.pe.

Paleoglaciation of the Tibetan Plateau based on exposure ages and ELA depression estimates

NASA Astrophysics Data System (ADS)

Heyman, Jakob

2014-05-01

The Tibetan Plateau holds a major part of all glaciers outside the polar regions and an ample record of past glaciations. The glacial history of the Tibetan Plateau has attracted significant interest, with a large body of research investigating the extent, timing, and climatic implications of past glaciations. Here I present an extensive compilation of exposure ages and equilibrium line altitude (ELA) depression estimates from glacial deposits across the Tibetan Plateau to address the timing and degree of past glaciations. I compiled Be-10 exposure age data for a total of 1877 samples and recalculated exposure ages using an updated (lower) global Be-10 production rate. All samples were organized in groups of individual glacial deposits where each deposit represents one glacial event enabling evaluation of the exposure age clustering. For each glacial deposit I estimated the ELA depression based on a simple toe to headwall ratio approach using Google Earth. To discriminate good (well-clustered) from poor (scattered) exposure age groups the glacial deposits were divided into three groups based on exposure age clustering. A major part of the glacial deposits have scattered exposure ages affected by prior or incomplete exposure, complicating exposure age interpretations. The well-clustered exposure age groups are primarily from mountain ranges along the margins of the Tibetan Plateau with a main peak in age between 10 and 30 ka, indicating glacial advances during the global last glacial maximum (LGM). A large number of exposure ages older than 30 ka indicates maximum glaciation predating the LGM, but the exposure age scatter generally prohibits accurate definition of the glacial chronology. The ELA depression estimates scatter significantly, but a major part is remarkably low. Average ELA depressions of 333 ± 191 m for the LGM and 494 ± 280 m for the pre-LGM exposure indicate restricted glacier expansion and limited glacial cooling.

COPPER Students - ELaNa IV

NASA Image and Video Library

2013-07-11

The Close Orbiting Propellant Plume Elemental Recognition (COPPER) was developed by students from St. Louis University as a technology demonstration mission whose objective is to test the suitability of a commercially-available compact uncooled microbolometer (tiny infrared camera) array for scientific imagery of Earth in the long-wave infrared range (LWIR, 7-13 microns). Launched by NASA’s CubeSat Launch Initiative on the ELaNa IV mission as an auxiliary payload aboard the U.S. Air Force-led Operationally Responsive Space (ORS-3) Mission on November 19, 2013.

Genetic Induction of Cytolytic Susceptibility in Breast Cancer Cells

DTIC Science & Technology

2001-07-01

human tumor cells have been contrasted with breast cancer cells for this same reason. The original two tasks continue to provide the focus for this...tissue type but may be generally applicable to many or all types of human tumors. The complementary question to that of cell type specificity was...transfection with either the adenoviral ElA oncogene or the E7 oncogene from human papilloma virus type 18. The question was whether both ElA and E7

A modeling study of the effect of runoff variability on the effective pressure beneath Russell Glacier, West Greenland

NASA Astrophysics Data System (ADS)

de Fleurian, Basile; Morlighem, Mathieu; Seroussi, Helene; Rignot, Eric; van den Broeke, Michiel R.; Kuipers Munneke, Peter; Mouginot, Jeremie; Smeets, Paul C. J. P.; Tedstone, Andrew J.

2016-10-01

Basal sliding is a main control on glacier flow primarily driven by water pressure at the glacier base. The ongoing increase in surface melting of the Greenland Ice Sheet warrants an examination of its impact on basal water pressure and in turn on basal sliding. Here we examine the case of Russell Glacier, in West Greenland, where an extensive set of observations has been collected. These observations suggest that the recent increase in melt has had an equivocal impact on the annual velocity, with stable flow on the lower part of the drainage basin but accelerated flow above the Equilibrium Line Altitude (ELA). These distinct behaviors have been attributed to different evolutions of the subglacial draining system during and after the melt season. Here we use a high-resolution subglacial hydrological model forced by reconstructed surface runoff for the period 2008 to 2012 to investigate the cause of these distinct behaviors. We find that the increase in meltwater production at low elevation yields a more efficient drainage system compatible with the observed stagnation of the mean annual flow below the ELA. At higher elevation, the model indicates that the drainage system is mostly inefficient and is therefore strongly sensitive to an increase in meltwater availability, which is consistent with the observed increase in ice velocity.

Adhesion of Silicone Elastomer Seals for NASA's Crew Exploration Vehicle

NASA Technical Reports Server (NTRS)

deGroh, Henry C., III; Miller, Sharon K. R.; Smith, Ian M.; Daniels, Christopher C.; Steinetz, Bruce M

2008-01-01

Silicone rubber seals are being considered for a number of interfaces on NASA's Crew Exploration Vehicle (CEV). Some of these joints include the docking system, hatches, and heat shield-to-back shell interface. A large diameter molded silicone seal is being developed for the Low Impact Docking System (LIDS) that forms an effective seal between the CEV and International Space Station (ISS) and other future Constellation Program spacecraft. Seals between the heat shield and back shell prevent high temperature reentry gases from leaking into the interface. Silicone rubber seals being considered for these locations have inherent adhesive tendencies that would result in excessive forces required to separate the joints if left unchecked. This paper summarizes adhesion assessments for both as-received and adhesion-mitigated seals for the docking system and the heat shield interface location. Three silicone elastomers were examined: Parker Hannifin S0899-50 and S0383-70 compounds, and Esterline ELA-SA-401 compound. For the docking system application various levels of exposure to atomic oxygen (AO) were evaluated. Moderate AO treatments did not lower the adhesive properties of S0899-50 sufficiently. However, AO pretreatments of approximately 10(exp 20) atoms/sq cm did lower the adhesion of S0383-70 and ELA-SA-401 to acceptable levels. For the heat shield-to-back shell interface application, a fabric covering was also considered. Molding Nomex fabric into the heat shield pressure seal appreciably reduced seal adhesion for the heat shield-to-back shell interface application.

Nano-crystallization in ZnO-doped In2O3 thin films via excimer laser annealing for thin-film transistors

NASA Astrophysics Data System (ADS)

Fujii, Mami N.; Ishikawa, Yasuaki; Ishihara, Ryoichi; van der Cingel, Johan; Mofrad, Mohammad R. T.; Bermundo, Juan Paolo Soria; Kawashima, Emi; Tomai, Shigekazu; Yano, Koki; Uraoka, Yukiharu

2016-06-01

In a previous work, we reported the high field effect mobility of ZnO-doped In2O3 (IZO) thin film transistors (TFTs) irradiated by excimer laser annealing (ELA) [M. Fujii et al., Appl. Phys. Lett. 102, 122107 (2013)]. However, a deeper understanding of the effect of ELA on the IZO film characteristics based on crystallinity, carrier concentrations, and optical properties is needed to control localized carrier concentrations for fabricating self-aligned structures in the same oxide film and to adequately explain the physical characteristics. In the case of as-deposited IZO film used as the channel, a high carrier concentration due to a high density of oxygen vacancies was observed; such a film does not show the required TFT characteristics but can act as a conductive film. We achieved a decrease in the carrier concentration of IZO films by crystallization using ELA. This means that ELA can form localized conductive or semi-conductive areas on the IZO film. We confirmed that the reason for the carrier concentration decrease was the decrease of oxygen-deficient regions and film crystallization. The annealed IZO films showed nano-crystalline phase, and the temperature at the substrate was substantially less than the temperature limit for flexible films such as plastic, which is 50°C. This paves the way for the formation of self-aligned structures and separately formed conductive and semi-conductive regions in the same oxide film.

NASA Laboratory Analysis for Manned Exploration Missions

NASA Technical Reports Server (NTRS)

Krihak, Michael K.; Shaw, Tianna E.

2014-01-01

The Exploration Laboratory Analysis (ELA) project supports the Exploration Medical Capability Element under the NASA Human Research Program. ELA instrumentation is identified as an essential capability for future exploration missions to diagnose and treat evidence-based medical conditions. However, mission architecture limits the medical equipment, consumables, and procedures that will be available to treat medical conditions during human exploration missions. Allocated resources such as mass, power, volume, and crew time must be used efficiently to optimize the delivery of in-flight medical care. Although commercial instruments can provide the blood and urine based measurements required for exploration missions, these commercial-off-the-shelf devices are prohibitive for deployment in the space environment. The objective of the ELA project is to close the technology gap of current minimally invasive laboratory capabilities and analytical measurements in a manner that the mission architecture constraints impose on exploration missions. Besides micro gravity and radiation tolerances, other principal issues that generally fail to meet NASA requirements include excessive mass, volume, power and consumables, and nominal reagent shelf-life. Though manned exploration missions will not occur for nearly a decade, NASA has already taken strides towards meeting the development of ELA medical diagnostics by developing mission requirements and concepts of operations that are coupled with strategic investments and partnerships towards meeting these challenges. This paper focuses on the remote environment, its challenges, biomedical diagnostics requirements and candidate technologies that may lead to successful blood-urine chemistry and biomolecular measurements in future space exploration missions.

Transcriptome analysis of the brain of the silkworm Bombyx mori infected with Bombyx mori nucleopolyhedrovirus: A new insight into the molecular mechanism of enhanced locomotor activity induced by viral infection.

PubMed

Wang, Guobao; Zhang, Jianjia; Shen, Yunwang; Zheng, Qin; Feng, Min; Xiang, Xingwei; Wu, Xiaofeng

2015-06-01

Baculoviruses have been known to induce hyperactive behavior in their lepidopteran hosts for over a century. As a typical lepidopteran insect, the silkworm Bombyx mori displays enhanced locomotor activity (ELA) following infection with B. mori nucleopolyhedrovirus (BmNPV). Some investigations have focused on the molecular mechanisms underlying this abnormal hyperactive wandering behavior due to the virus; however, there are currently no reports about B. mori. Based on previous studies that have revealed that behavior is controlled by the central nervous system, the transcriptome profiles of the brains of BmNPV-infected and non-infected silkworm larvae were analyzed with the RNA-Seq technique to reveal the changes in the BmNPV-infected brain on the transcriptional level and to provide new clues regarding the molecular mechanisms that underlies BmNPV-induced ELA. Compared with the controls, a total of 742 differentially expressed genes (DEGs), including 218 up-regulated and 524 down-regulated candidates, were identified, of which 499, 117 and 144 DEGs could be classified into GO categories, KEGG pathways and COG annotations by GO, KEGG and COG analyses, respectively. We focused our attention on the DEGs that are involved in circadian rhythms, synaptic transmission and the serotonin receptor signaling pathway of B. mori. Our analyses suggested that these genes were related to the locomotor activity of B. mori via their essential roles in the regulations of a variety of behaviors and the down-regulation of their expressions following BmNPV infection. These results provide new insight into the molecular mechanisms of BmNPV-induced ELA. Copyright © 2015 Elsevier Inc. All rights reserved.

LighSail Students Testing - ELaNa XI

NASA Image and Video Library

2014-09-23

Students Alex Diaz and Riki Munakata of California Polytechnic State University testing the LightSail CubeSat. LightSail is a citizen-funded technology demonstration mission sponsored by the Planetary Society using solar propulsion for CubeSats. The spacecraft is designed to “sail” on the energy of solar photons striking the thin, reflective sail material. The first LightSail mission is designed to test the spacecraft’s critical systems, including the sequence to autonomously deploy a Mylar solar sail with an area of 32 square meters (344 square feet). The Planetary Society is planning a second, full solar sailing demonstration flight for 2016. Light is made of packets of energy called photons. While photons have no mass, they have energy and momentum. Solar sails use this momentum as a method of propulsion, creating flight by light. LightSail’s solar sail is packaged into a three-unit CubeSat about the size of a loaf of bread. Launched by NASA’s CubeSat Launch Initiative on the ELaNa XI mission as an auxiliary payload aboard the U.S. Air Force X-37B space plane mission on May 20, 2015.

Atmospheric dynamics over Europe during the Younger Dryas revealed by palaeoglaciers.

NASA Astrophysics Data System (ADS)

Rea, Brice; Pellitero, Ramon; Spagnolo, Matteo; Hughes, Philip; Braithwaite, Roger; Renssen, Hans; Ivy-Ochs, Susan; Ribolini, Adriano; Bakke, Jostein; Lukas, Sven

2017-04-01

A dataset of 120 palaeoglaciers ranging from Morocco in the south to Svalbard in the north and from Ireland in the west to Turkey in the east, has been assembled from the literature. A robust quality control on the chronology was undertaken and, when derived from cosmogenic nuclides, ages were recalculated using the most up-to-date production rates. All the reconstructed glaciers date to the Younger Dryas. Frontal moraines/limits were used to initiate the palaeoglacier reconstructions using GlaRe, a GIS tool which generates an equilibrium profile ice surface along a single flowline and extrapolates this to out to a 3D ice surface. From the resulting glacier surfaces palaeo-ELAs were calculated within the GIS. Where multiple glaciers were reconstructed within in a region, a single ELA value was generated. Results show that ELAs decrease with latitude but have a more complex pattern with longitude. A database of 121 sites, spanning the same geographical range as the palaeoglaciers, was compiled for Younger Dryas temperature, determined from palaeoproxies, for example pollen, diatoms, coleoptera, chironimids etc. These proxy data were merged and interpolated to generate maps of average temperature for the warmest and coldest months and annual average temperature. Results show that, in general, temperature decreases with latitude. Temperature at the palaeo-ELAs were determined from the temperature maps using a lapse rate of 0.65°C/100m and the precipitation required for equilibrium was calculated. Positive precipitation anomalies are found along much of the western seaboard of Europe, with the most striking positive anomalies present in the eastern Mediterranean. Negative precipitation anomalies appear on the northern side of the Alps. This pattern is interpreted to represent a southward displaced polar frontal jet stream with a concomitant track of Atlantic mid-latitude depressions, leading to more frequent incursions of low pressure systems especially over the relatively warm eastern Mediterranean, enhancing cyclogenesis. This is similar to the modern Scandinavia (SCAND) pattern which, in its positive phase, is characterised by a high pressure anomaly over Fennoscandia and western Russia, negative pressure anomalies around the Iberian Peninsula and enhanced cyclogenesis in the central and eastern Mediterranean. During the YD the Fennoscandian Ice Sheet and permafrost across much of northern continental Europe and Russia would have generated a high pressure region leading to a persistent, enhanced SCAND circulation.

Holocene glacier variability and Neoglacial hydroclimate at Ålfotbreen, western Norway

NASA Astrophysics Data System (ADS)

Gjerde, Marthe; Bakke, Jostein; Vasskog, Kristian; Nesje, Atle; Hormes, Anne

2016-02-01

Glaciers and small ice caps respond rapidly to climate perturbations (mainly winter precipitation, and summer temperature), and the mass-balance of glaciers located in western Norway is governed mainly by winter precipitation (Pw). Records of past Pw can offer important insight into long-term changes in atmospheric circulation, but few proxies are able to accurately capture winter climate variations in Scandinavia. Reconstructions of equilibrium-line-altitude (ELA) variations from glaciers that are sensitive to changes in Pw therefore provide a unique opportunity to quantify past winter climate in this region. Here we present a new, Holocene glacier activity reconstruction for the maritime ice cap Ålfotbreen in western Norway, based on investigations of distal glacier-fed lake sediments and modern mass balance measurements (1963-2010). Several lake sediment cores have been subject to a suite of laboratory analyses, including measurements of physical parameters such as dry bulk density (DBD) and loss-on-ignition (LOI), geochemistry (XRF), surface magnetic susceptibility (MS), and grain size distribution, to identify glacial sedimentation in the lake. Both radiocarbon (AMS 14C) and 210Pb dating were applied to establish age-depth relationships in the sediment cores. A novel approach was used to calibrate the sedimentary record against a simple ELA model, which allowed reconstruction of continuous ELA changes for Ålfotbreen during the Neoglacial (when Ålfotbreen was present, i.e. the last ∼1400 years). Furthermore, the resulting ELA variations were combined with an independent summer temperature record to calculate Neoglacial Pw using the 'Liestøl equation'. The resulting Pw record is of higher resolution than previous reconstructions from glaciers in Norway and shows the potential of glacier records to provide high-resolution data reflecting past variations in hydroclimate. Complete deglaciation of the Ålfotbreen occurred ∼9700 cal yr BP, and the ice cap was subsequently absent or very small until a short-lived glacier event is seen in the lake sediments ∼8200 cal yr BP. The ice cap was most likely completely melted until a new glacier event occurred around ∼5300 cal yr BP, coeval with the onset of the Neoglacial at several other glaciers in southwestern Norway. Ålfotbreen was thereafter absent (or very small) until the onset of the Neoglacial period ∼1400 cal yr BP. The 'Little Ice Age' (LIA) ∼650-50 cal yr BP was the largest glacier advance of Ålfotbreen since deglaciation, with a maximum extent at ∼400-200 cal yr BP, when the ELA was lowered approximately 200 m relative to today. The late onset of the Neoglacial at Ålfotbreen is suggested to be a result of its low altitude relative to the regional ELA. A synthesis of Neoglacial ELA fluctuations along the coast of Norway indicates a time-transgressive trend in the maximum extent of the LIA, which apparently seems to have occurred progressively later as we move northwards. We suggest that this trend is likely due to regional winter precipitation differences along the coast of Norway.

Parp-1 genetic ablation in Ela-myc mice unveils novel roles for Parp-1 in pancreatic cancer.

PubMed

Martínez-Bosch, Neus; Iglesias, Mar; Munné-Collado, Jessica; Martínez-Cáceres, Carlos; Moreno, Mireia; Guerra, Carmen; Yélamos, Jose; Navarro, Pilar

2014-10-01

Pancreatic cancer has a dismal prognosis and is currently the fourth leading cause of cancer-related death in developed countries. The inhibition of poly(ADP-ribose) polymerase-1 (Parp-1), the major protein responsible for poly(ADP-ribosy)lation in response to DNA damage, has emerged as a promising treatment for several tumour types. Here we aimed to elucidate the involvement of Parp-1 in pancreatic tumour progression. We assessed Parp-1 protein expression in normal, preneoplastic and pancreatic tumour samples from humans and from K-Ras- and c-myc-driven mouse models of pancreatic cancer. Parp-1 was highly expressed in acinar cells in normal and cancer tissues. In contrast, ductal cells expressed very low or undetectable levels of this protein, both in a normal and in a tumour context. The Parp-1 expression pattern was similar in human and mouse samples, thereby validating the use of animal models for further studies. To determine the in vivo effects of Parp-1 depletion on pancreatic cancer progression, Ela-myc-driven pancreatic tumour development was analysed in a Parp-1 knock-out background. Loss of Parp-1 resulted in increased tumour necrosis and decreased proliferation, apoptosis and angiogenesis. Interestingly, Ela-myc:Parp-1(-/-) mice displayed fewer ductal tumours than their Ela-myc:Parp-1(+/+) counterparts, suggesting that Parp-1 participates in promoting acinar-to-ductal metaplasia, a key event in pancreatic cancer initiation. Moreover, impaired macrophage recruitment can be responsible for the ADM blockade found in the Ela-myc:Parp-1(-/-) mice. Finally, molecular analysis revealed that Parp-1 modulates ADM downstream of the Stat3-MMP7 axis and is also involved in transcriptional up-regulation of the MDM2, VEGFR1 and MMP28 cancer-related genes. In conclusion, the expression pattern of Parp-1 in normal and cancer tissue and the in vivo functional effects of Parp-1 depletion point to a novel role for this protein in pancreatic carcinogenesis and shed light into the clinical use of Parp-1 inhibitors. Copyright © 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Southern Alaska as an Example of the Long-Term Consequences of Mountain Building Under the Influence of Glaciers

NASA Technical Reports Server (NTRS)

Meigs, Andrew; Sauber, Jeanne

2000-01-01

Southern Alaska is a continent-scale region of ongoing crustal deformation within the Pacific-North American plate boundary zone. Glaciers and glacial erosion have dictated patterns of denudation in the orogen over the last approx. 5 My. The orogen comprises three discrete topographic domains from south to north, respectively: (1) the Chugach/St. Elias Range; (2) the Wrangell Mountains; and (3) the eastern Alaska Range. Although present deformation is distributed across the orogen, much of the shortening and uplift are concentrated in the Chugach/St. Elias Range. A systematic increase in topographic wavelength of the range from east to west reflects east-to-west increases in the width of a shallowly-dipping segment of the plate interface, separation of major upper plate structures, and a decrease in the obliquity of plate motion relative to the plate boundary. Mean elevation decays exponentially from approx. 2500 m to approx. 1100 m from east to west, respectively. Topographic control on the present and past distribution of glaciers is indicated by close correspondence along the range between mean elevation and the modern equilibrium line altitude of glaciers (ELA) and differences in the modern ELA, mean annual precipitation and temperature across the range between the windward, southern and leeward, northern flanks. Net, range- scale erosion is the sum of: (1) primary bedrock erosion by glaciers and (2) erosion in areas of the landscape that are ice-marginal and are deglaciated at glacial minima. Oscillations between glacial and interglacial climates controls ice height and distribution, which, in turn, modulates the locus and mode of erosion in the landscape. Mean topography and the mean position of the ELA are coupled because of the competition between rock uplift, which tends to raise the ELA, and enhanced orographic precipitation accompanying mountain building, which tends to lower the ELA. Mean topography is controlled both by the 60 deg latitude and maritime setting of active deformation and by the feedback between shortening and uplift, glacial erosion, and orographic effects on climate accompanying mountain building.

Younger Dryas glaciers in the High Atlas, Morocco

NASA Astrophysics Data System (ADS)

Hughes, Philip; Fink, David

2016-04-01

Twelve cirque glaciers formed during the Younger Dryas on the mountains of Aksoual (3912 m a.s.l.) and Adrar el Hajj (3129 m a.s.l.) in the Marrakesh High Atlas. Moraines in two separate cirques on these mountains have been dated using 10Be and 36Cl exposure dating. In both cirques the age scatter is relatively small (13.8-10.1 ka) and all ages overlap within error with the Younger Dryas (12.9-11.7 ka). The glaciers were small and covered <2 km2 and formed on north-facing slopes. However, the altitudinal range of the glaciers was very large, with equilibrium line altitudes (ELAs) ranging from 2470 and 3560 m. This large range is attributed to local topoclimatic factors with the lowest glacier (confirmed as Younger Dryas in age by 3 exposure ages) occupying a very steep cirque floor where a combination of steep glacier gradient and a large potential avalanche catchment enabled its low-lying position. This indicates that caution should be taken when using single glacier sites for reconstructing regional palaeoclimate, especially those formed in steep catchments that have strong topoclimatic controls. The average ELA of the twelve Younger Dryas glaciers was c. 3109 m a.s.l. (St Dev = 325 m) and this represents an ELA depression of > 1000 m from the modern theoretical regional ELA. Under precipitation values similar to today this would require a mean annual temperature depression of 9°C. Moreover, the glacier-climate modelling indicates that it is very unlikely that climate was drier than today during the Younger Dryas in the Marrakesh High Atlas.

Gene expression profiles in primary pancreatic tumors and metastatic lesions of Ela-c-myc transgenic mice.

PubMed

Thakur, Archana; Bollig, Aliccia; Wu, Jiusheng; Liao, Dezhong J

2008-01-24

Pancreatic carcinoma usually is a fatal disease with no cure, mainly due to its invasion and metastasis prior to diagnosis. We analyzed the gene expression profiles of paired primary pancreatic tumors and metastatic lesions from Ela-c-myc transgenic mice in order to identify genes that may be involved in the pancreatic cancer progression. Differentially expressed selected genes were verified by semi-quantitative and quantitative RT-PCR. To further evaluate the relevance of some of the selected differentially expressed genes, we investigated their expression pattern in human pancreatic cancer cell lines with high and low metastatic potentials. Data indicate that genes involved in posttranscriptional regulation were a major functional category of upregulated genes in both primary pancreatic tumors (PT) and liver metastatic lesions (LM) compared to normal pancreas (NP). In particular, differential expression for splicing factors, RNA binding/pre-mRNA processing factors and spliceosome related genes were observed, indicating that RNA processing and editing related events may play critical roles in pancreatic tumor development and progression. High expression of insulin growth factor binding protein-1 (Igfbp1) and Serine proteinase inhibitor A1 (Serpina1), and low levels or absence of Wt1 gene expression were exclusive to liver metastatic lesion samples. We identified Igfbp1, Serpina1 and Wt1 genes that are likely to be clinically useful biomarkers for prognostic or therapeutic purposes in metastatic pancreatic cancer, particularly in pancreatic cancer where c-Myc is overexpressed.

Development of a biodegradable tissue adhesive based on functionalized 1,2-ethylene glycol bis(dilactic acid). II.

PubMed

Rohm, Henning W; Lurtz, Claudia; Wegmann, Juergen; Odermatt, Erich K; Behrend, Detlef; Schmitz, Klaus-Peter; Sternberg, Katrin

2011-04-01

In body regions where damage and bleeding must be avoided, a substitute for mechanical tissue fixation by sutures or staplers is needed. Since tissue adhesives provide easy and fast handling they are a promising alternative. The present study reports the development and analysis of a tissue adhesive that consists of two adhesive components: hexamethylene diisocyanate (HDI) functionalized 1,2-ethylene glycol bis(dilactic acid) (ELA-NCO) and chitosan chloride. This composition was chosen based on preliminary studies on several chain elongation agents. The present study evaluates this adhesive system by IR-spectroscopy, tensile tests, and gel point measurements in comparison to fibrin glue. The system's in vitro biocompatibility was tested with mouse fibroblasts (L929) according to ISO 10993-5. Furthermore, an implantation study was performed in SPF-Wistar rats. The adhesive strength of manually applied mixtures or mixtures applied by double chamber syringes with a mixing extruder was determined to be significantly higher than that of fibrin glue on bovine muscle tissue at 37°C. Tensile strength increased further when exposure time of the adhesive was increased from 10 min to 48 h. The rheological gel point determination showed that the mixture of ELA-NCO/DMSO and chitosan chloride offers a time window large enough to readjust the fused joint during surgery, as opposed to fibrin glue. Additionally, the in vitro and in vivo biocompatibility studies of the adhesive system revealed no toxic effects on the surrounding tissue. Copyright © 2010 Wiley Periodicals, Inc.

Age and significance of former low-altitude corrie glaciers on Hoy, Orkney Islands

USGS Publications Warehouse

Ballantyne, C.K.; Hall, A.M.; Phillips, W.; Binnie, S.; Kubik, P.W.

2007-01-01

Geomorphological mapping provides evidence for two former low-level corrie glaciers on Hoy, both defined by end moraines. Five 10Be exposure ages obtained from sandstone boulders on moraine crests fall within the range 12.4??1.5 ka to 10.4??1.7 ka (weighted mean 11.7??0.6 ka), confirming that these glaciers developed during the Loch Lomond (Younger Dryas) Stade (LLS) of 12.9-11.5 cal. ka BP, and demonstrate the feasibility of using this approach to establish the age of LLS glacier limits. The equilibrium line altitude (ELA) of one of the glaciers (99 m) is the lowest recorded for any LLS glacier, and the area-weighted mean ELA for both (141 m) is consistent with a general northward ELA decrease along the west coast of Britain. The size of moraines fronting these small (???0.75 km2) glaciers implies that glacier termini remained at or close to their limits for a prolonged period. The apparent restriction of LLS glaciers to only two sites on Hoy probably reflects topographic favourability, and particularly the extent of snow-contributing areas.

Glaciological and hydrological sensitivities in the Hindu Kush - Himalaya

NASA Astrophysics Data System (ADS)

Shea, Joseph; Immerzeel, Walter

2016-04-01

Glacier responses to future climate change will affect hydrology at subbasin-scales. The main goal of this study is to assess glaciological and hydrological sensitivities of sub-basins throughout the Hindu Kush - Himalaya (HKH) region. We use a simple geometrical analysis based on a full glacier inventory and digital elevation model (DEM) to estimate sub-basin equilibrium line altitudes (ELA) from assumptions of steady-state accumulation area ratios (AARs). The ELA response to an increase in temperature is expressed as a function of mean annual precipitation, derived from a range of high-altitude studies. Changes in glacier contributions to streamflow in response to increased temperatures are examined for scenarios of both static and adjusted glacier geometries. On average, glacier contributions to streamflow increase by approximately 50% for a +1K warming based on a static geometry. Large decreases (-60% on average) occur in all basins when glacier geometries are instantaneously adjusted to reflect the new ELA. Finally, we provide estimates of sub-basin glacier response times that suggest a majority of basins will experience declining glacier contributions by the year 2100.

Hypsometry and the distribution of high-alpine lakes in the European Alps

NASA Astrophysics Data System (ADS)

Prasicek, Günther; Otto, Jan-Christoph; Buckel, Johannes; Keuschnig, Markus

2017-04-01

Climate change strongly affects alpine landscapes. Cold-climate processes shape the terrain in a typical way and ice-free overdeepenings in cirques and glacial valleys as well as different types of moraines favor the formation of lakes. These water bodies act as sediment sinks and high-alpine water storage but may also favor outburst and flooding events. Glacier retreat worldwide is associated with an increasing number and size of high-alpine lakes which implies a concurrent expansion of sediment retention and natural hazard potential. Rising temperatures are regarded to be the major cause for this development, but other factors such as the distribution of area over elevation and glacier erosional and depositional dynamics may play an important role as well. While models of ice flow and glacial erosion are employed to understand the impact of glaciers on mountain landscapes, comprehensive datasets and analyses on the distribution of existing high-alpine lakes are lacking. In this study we present an exhaustive database of natural lakes in the European Alps and analyze lake distribution with respect to hypsometry. We find that the distribution of lake number and lake area over elevation only weakly coincides with hypsometry. Unsurprisingly, largest lakes are often tectonically influenced and located at the fringe of the mountain range and in prominent inter-montane basins. With increasing elevation, however, the number of lakes, lake area and total area decrease until a local minimum is reached around the equilibrium line latitude (ELA) of the last glacial maximum (LGM). Above the LGM ELA, total area further decreases, but lake number and area increase again. A local maximum in lake area coincides with an absolute maximum in lake number between the ELAs of the LGM and the little ice age around 2500 m. We conclude that glacial erosional and depositional dynamics control the distribution and size of high-alpine lakes and thus demand for exceptional attention when predicting future lake development.

Exploration Laboratory Analysis FY13

NASA Technical Reports Server (NTRS)

Krihak, Michael; Perusek, Gail P.; Fung, Paul P.; Shaw, Tianna, L.

2013-01-01

The Exploration Laboratory Analysis (ELA) project supports the Exploration Medical Capability (ExMC) risk, which is stated as the Risk of Inability to Adequately Treat an Ill or Injured Crew Member, and ExMC Gap 4.05: Lack of minimally invasive in-flight laboratory capabilities with limited consumables required for diagnosing identified Exploration Medical Conditions. To mitigate this risk, the availability of inflight laboratory analysis instrumentation has been identified as an essential capability in future exploration missions. Mission architecture poses constraints on equipment and procedures that will be available to treat evidence-based medical conditions according to the Space Medicine Exploration Medical Conditions List (SMEMCL), and to perform human research studies on the International Space Station (ISS) that are supported by the Human Health and Countermeasures (HHC) element. Since there are significant similarities in the research and medical operational requirements, ELA hardware development has emerged as a joint effort between ExMC and HHC. In 2012, four significant accomplishments were achieved towards the development of exploration laboratory analysis for medical diagnostics. These achievements included (i) the development of high priority analytes for research and medical operations, (ii) the development of Level 1 functional requirements and concept of operations documentation, (iii) the selection and head-to-head competition of in-flight laboratory analysis instrumentation, and (iv) the phase one completion of the Small Business Innovation Research (SBIR) projects under the topic Smart Phone Driven Blood-Based Diagnostics. To utilize resources efficiently, the associated documentation and advanced technologies were integrated into a single ELA plan that encompasses ExMC and HHC development efforts. The requirements and high priority analytes was used in the selection of the four in-flight laboratory analysis performers. Based upon the competition results, a down select process will be performed in the upcoming year. Looking ahead, this unified effort has positioned each element for an in-flight lab analysis demonstration of select diagnostics measurements in the 2015 timeframe.

Flexible phosphorescent OLEDs on metal foil for military and commercial applications

NASA Astrophysics Data System (ADS)

Chwang, Anna; Lu, JengPing; Shih, Chinwen; Tung, Yeh-Jiun; Hewitt, Richard; Hack, Michael; Ho, Jackson; Brown, Julie

2005-05-01

We report recent advances in the development of low power consumption, emissive, flexible active matrix displays through integration of top emitting phosphorescent OLED (T-PHOLED) and poly-Si TFT backplane technologies. The displays are fabricated on flexible stainless steel foil. The T-PHOLEDs are based on UDC phosphorescent OLED technology, and the backplane is based on PARC's Excimer Laser Annealed (ELA) poly-Si TFT process. We also present progress in operational lifetime of encapsulated T-PHOLED pixels on planarized metal foil and discuss PHOLED encapsulation strategy.

Space Environment Effects on Silicone Seal Materials

NASA Technical Reports Server (NTRS)

deGroh, Henry C., III; Daniels, Christopher C.; Dever, Joyce A.; Miller, Sharon K.; Waters, Deborah L.; Finkbeiner, Joshua R.; Dunlap, Patrick H.; Steinetz, Bruce M.

2010-01-01

A docking system is being developed by the NASA to support future space missions. It is expected to use redundant elastomer seals to help contain cabin air during dockings between two spacecraft. The sealing surfaces are exposed to the space environment when vehicles are not docked. In space, the seals will be exposed to temperatures between 125 to -75 C, vacuum, atomic oxygen, particle and ultraviolet radiation, and micrometeoroid and orbital debris (MMOD). Silicone rubber is the only class of space flight-qualified elastomeric seal material that functions across the expected temperature range. NASA Glenn has tested three silicone elastomers for such seal applications: two provided by Parker (S0899-50 and S0383-70) and one from Esterline (ELA-SA-401). The effects of atomic oxygen (AO), UV and electron particle radiation, and vacuum on the properties of these three elastomers were examined. Critical seal properties such as leakage, adhesion, and compression set were measured before and after simulated space exposures. The S0899-50 silicone was determined to be inadequate for extended space seal applications due to high adhesion and intolerance to UV, but both S0383-70 and ELA-SA-401 seals were adequate.

Proglacial River Reveals Substantial Greenland Ice Sheet Climate Sensitivity and Meltwater Routing Delays

NASA Astrophysics Data System (ADS)

van As, D.; Mikkelsen, A. B.; Holtegaard Nielsen, M.; Claesson Liljedahl, L.; Lindback, K.; Pitcher, L. H.; Hasholt, B.

2016-12-01

A 12.000 km2 area of the Greenland ice sheet discharges meltwater via the proglacial Watson River in west Greenland. In a ten-year time span of continuous monitoring (2006-2015), the river discharged 3.8 km3 to 11.2 km3 yr-1. The large interannual variability is for an important part explained by hypsometric amplification: the flattening of the ice sheet with elevation adds 70% meltwater discharge sensitivity to atmospheric temperature. Comparing river discharge with ice sheet surface meltwater production from an observation-based surface mass balance model we quantify multiple-day routing delays for meltwater transit through the supra-, en-, sub- and proglacial system. This delay increases with ice sheet surface elevation: on average five days for surface water at the previous-known equilibrium line altitude (ELA) of ca. 1550 m, and seven days at the 2009-2015 ELA of ca. 1800 m above sea level. A flooding of the Kangerlussuaq bridge as in July 2012 thus requires a multi-day high-melt episode and can therefore be anticipated by in-situ monitoring of ice sheet melt. No evidence of significant en- or subglacial meltwater retention is found.

Parent-child acculturation profiles as predictors of Chinese American adolescents' academic trajectories.

PubMed

Kim, Su Yeong; Wang, Yijie; Chen, Qi; Shen, Yishan; Hou, Yang

2015-06-01

Acculturation plays a critical role in the adjustment of Asian Americans, as a large proportion of them are immigrants in the US. However, little is known about how acculturation influences Asian American adolescents' academic trajectories over time. Using a longitudinal sample of 444 Chinese American families (54% female children), the current study explored the effect of mothers', fathers', and adolescents' individual acculturation profiles and parent-child acculturation dissonance on adolescents' academic trajectories from 8th to 12th grade. Academic performance was measured by grade point average (GPA), and by standardized test scores in English language arts (ELA) and Math every year. Latent growth modeling analyses showed that adolescents with a Chinese-oriented father showed faster decline in GPA, and Chinese-oriented adolescents had lower initial ELA scores. Adolescents whose parents had American-oriented acculturation profiles tended to have lower initial Math scores. These results suggest that Chinese and American profiles may be disadvantageous for certain aspects of academic performance, and bicultural adolescents and/or adolescents with bicultural parents are best positioned to achieve across multiple domains. In terms of the role of parent-child acculturation dissonance on academic trajectories, the current study highlighted the importance of distinguishing among different types of dissonance. Adolescents who were more Chinese-oriented than their parents tended to have the lowest initial ELA scores, and adolescents experiencing more normative acculturation dissonance (i.e., who were more American-oriented than their parents) had the highest initial ELA scores. No effects of parent-child acculturation dissonance were observed for GPAs or standardized Math scores. Altogether, the current findings add nuances to the current understanding of acculturation and adolescent adjustment.

Parent-Child Acculturation Profiles as Predictors of Chinese American Adolescents’ Academic Trajectories

PubMed Central

Kim, Su Yeong; Wang, Yijie; Chen, Qi; Shen, Yishan; Hou, Yang

2014-01-01

Acculturation plays a critical role in the adjustment of Asian Americans, as a large proportion of them are immigrants in the U.S. However, little is known about how acculturation influences Asian American adolescents’ academic trajectories over time. Using a longitudinal sample of 444 Chinese American families (54% female children), the current study explored the effect of mothers’, fathers’, and adolescents’ individual acculturation profiles and parent-child acculturation dissonance on adolescents’ academic trajectories from 8th to 12th grade. Academic performance was measured by Grade Point Average (GPA), and by standardized test scores in English Language Arts (ELA) and Math every year. Latent growth modeling analyses showed that adolescents with a Chinese-oriented father showed faster decline in GPA, and Chinese-oriented adolescents had lower initial ELA scores. Adolescents whose parents had American-oriented acculturation profiles tended to have lower initial Math scores. These results suggest that Chinese and American profiles may be disadvantageous for certain aspects of academic performance, and bicultural adolescents and/or adolescents with bicultural parents are best positioned to achieve across multiple domains. In terms of the role of parent-child acculturation dissonance on academic trajectories, the current study highlighted the importance of distinguishing among different types of dissonance. Adolescents who were more Chinese-oriented than their parents tended to have the lowest initial ELA scores, and adolescents experiencing more normative acculturation dissonance (i.e., who were more American-oriented than their parents) had the highest initial ELA scores. No effects of parent-child acculturation dissonance were observed for GPAs or standardized Math scores. Altogether, the current findings add nuances to the current understanding of acculturation and adolescent adjustment. PMID:24820295

Assessment of luteal function in the vervet monkey as a means to develop a model for obesity-related reproductive phenotype

PubMed Central

Kundu, Mila C.; May, Margaret C.; Chosich, Justin; Bradford, Andrew P.; Lasley, Bill; Gee, Nancy; Santoro, Nanette; Appt, Susan E.; Polotsky, Alex J.

2015-01-01

The objective of the current study was to characterize luteal function in vervet monkeys. Urine from 12 adult female vervets housed at an academic research center was collected for 10 weeks from single-caged monkeys in order to assess evidence of luteal activity (ELA) as determined by urinary excretion of pregnanediol glucuronide (Pdg) and estrone conjugates (E1c). Dual energy X-ray absorptiometry (DXA) was performed on the monkeys to assess body composition, bone density, and fat mass. Menstrual cyclicity was determined using records of vaginal bleeding. ELA was observed in 9 monkeys and was characterized by a late follicular rise in E1c followed by a progressive increase in Pdg excretion. Mean menstrual cycle length was 26.7 ± 3.8 days and the average day of luteal transition was 14 ± 1.8. Three monkeys without ELA had a clearly defined E1c rise (mean 12-fold from nadir) followed by an E1c drop that was not accompanied by Pdg rise and coincided with vaginal bleeding. Among the 9 ELA monkeys, excretion of E1c tended to negatively associate with fat mass, although this finding did not reach statistical significance (r = −0.61, p = 0.08). Similar to women, vervet monkeys experience an increase in E1c late in the follicular phase of the menstrual cycle which is followed by a subsequent luteal Pdg peak. Assessment of urinary reproductive hormones allows for identification of cardinal menstrual cycle events; thus, the similarity of vervet cycles to human menstrual cycles makes them a useful model for obesity-related human reproductive impairment. PMID:23278149

Investigation of Brittle Fractures in Graphite-Epoxy Composites Subjected to Impact

DTIC Science & Technology

1975-05-01

Dspertlmew of the Army position unless so des •i•ated by othr authrized documents. Men Goverment drawings. epeOsftions. or other data we used for any...FRACTURE CHARACTERISTICS OF SOME FIBER-STRENGTHEN,1ED EPOXY RESIN SYSTEMS, E. 1. duPont de Nemours and Company, Incorporated, Wilmington, Delaware...Corporation Report TR-0172(SZ816-15)- 1, December 1971. 35 a LAYERS WITH Ela DIFFERENIT C (EACH LAYER ISOTROPIC) E la E lb t Elc E’ In Vila V lb ý VIC

De-Icing Systems of Flight Vehicles. Bases of Design Methods for Testing. Part 1,

DTIC Science & Technology

1979-09-07

conducting filn; 2 - external glass; 3 - ela.tic Iajar; 4 - internal glass. Page 62. Therefore the film can be ueposited on many plastic transparent...specially developed polyester plastic "SayresijA-92011 dud of its varieties which many times are more stable agai.nst bcr~tches, than other transpar~r.t... plastics . Furthermore, aiii uaveoped the methcds of the restcratioji of glasses from solid plastic6 via the polishing of small/fine? scratches or with tho

Neutrophil elastase in cyclic and severe congenital neutropenia

PubMed Central

Duan, Zhijun; Korkmaz, Brice; Lee, Hu-Hui; Mealiffe, Matthew E.; Salipante, Stephen J.

2007-01-01

Mutations in ELA2 encoding the neutrophil granule protease, neutrophil elastase (NE), are the major cause of the 2 main forms of hereditary neutropenia, cyclic neutropenia and severe congenital neutropenia (SCN). Genetic evaluation of other forms of neutropenia in humans and model organisms has helped to illuminate the role of NE. A canine form of cyclic neutropenia corresponds to human Hermansky-Pudlak syndrome type 2 (HPS2) and results from mutations in AP3B1 encoding a subunit of a complex involved in the subcellular trafficking of vesicular cargo proteins (among which NE appears to be one). Rare cases of SCN are attributable to mutations in the transcriptional repressor Gfi1 (among whose regulatory targets also include ELA2). The ultimate biochemical consequences of the mutations are not yet known, however. Gene targeting of ELA2 has thus far failed to recapitulate neutropenia in mice. The cycling phenomenon and origins of leukemic transformation in SCN remain puzzling. Nevertheless, mutations in all 3 genes are capable of causing the mislocalization of NE and may also induce the unfolded protein response, suggesting that there might a convergent pathogenic mechanism focusing on NE. PMID:17053055

Modeling of subglacial water pressure on Russell glacier, toward a better understanding of the relation between meltwater availability and ice dynamics.

NASA Astrophysics Data System (ADS)

de Fleurian, Basile; Morlighem, Mathieu; Seroussi, Helene; Rignot, Eric

2016-04-01

Basal sliding is the main control on outlet glaciers velocity. This sliding is mainly driven by the water pressure at the base of the glaciers. The ongoing increase in surface melt of the Greenland Ice Sheet warrants an examination of its impact on basal water pressure and in turn on basal sliding. Here, we examine the case of Russell glacier, West Greenland, where a remarkably extensive set of observations have been gathered. These observations suggest that the increase in runoff has no impact on the annual velocity on the lower part of the drainage basin, but yield an acceleration of ice flow above the Equilibrium Line Altitude (ELA). It is believed that this two distinct behaviours are due to different evolutions of the subglacial draining system during and after the melt season. We use here a high-resolution new generation subglacial hydrological model forced by reconstructed surface runoff for the period 2008 to 2012 to investigate the possible causes of these distinct behaviours. The model results confirm the existence of two distinct behaviours of the subglacial water pressure, an increase in the mean annual water pressure at high elevation and a stagnation of these same mean annual pressures below the ELA. The increase in meltwater at the lower elevation leads to a more developed efficient drainage system and the overall steadiness of the annual velocities, but, at higher elevation the drainage system remains mainly inefficient and is therefore strongly sensitive to the increase in meltwater availability.

Glacier changes since Local Last Glacial Maximum in the South-West slope of Nevado Hualcán, Cordillera Blanca, Peru, deduced from moraine mapping and GIS-based analysis

NASA Astrophysics Data System (ADS)

Giráldez, Claudia; Palacios, David; Haeberli, Wilfried; Úbeda, Jose; Schauwecker, Simone; Torres, Judith

2014-05-01

Anticipating and assessing hazards and risks associated with the shrinking of surface and subsurface ice in cold mountain chains is facilitated by empirical-quantitative data on present and past rates of change, as well as by a general understanding of related landforms and landscape evolution through time. Rock/ice avalanches and devastating outburst floods from glacial lakes indeed constitute a major cause of severe damage in populated mountain areas such as the Cordillera Blanca whose combination of tectonic, topographic and glaciological characteristics make it a threatened region. This study focuses on the Río Chucchún catchment above the city of Carhuaz, which was recently affected by a flood/debris flow from a rock/ice avalanche impacting a recently grown lake (Laguna 513). Traces left by past glaciations strongly affect the current geomorphodinamic behaviour of the catchment. For instance, a prominent sediment-filled glacial overdeepening behind Younger Dryas (YD) moraines (Pampa de Shonquil) with its retention function strongly influenced the chain of processes initiated by the outburst of Laguna 513. The aim of this study is to reconstruct earlier glacial phases in the SW slope of Nevado Hualcán (Río Chucchún catchment), in order to compile quantitative information on surface areas and Equilibrium Line Altitudes (ELAs). To do so, glacier stages were assigned to five different glacial phases, through photointerpretation and moraine cartography: 2003; 1962; Hualcán-I-LIA (15th to 18th centuries); Hualcán-II-YD (~12,5 ka BP); and Hualcán-III-LLGM (~34 to 21 ka BP). Glacial stages Hualcán-I-LIA, Hualcán-II-YD and Hualcán-III-LLGM present relative dating based on previous studies from different authors in the Peruvian Andes. Once glaciers were delimited, their surface areas and Equilibrium Line Altitudes (ELAs) were calculated. For ELA estimation three different methods were used: the mid-range elevation, the Accumulation Area Ratio (AAR), and the Area x Altitude Balance Ratio (AABR). The results show a decrease in surface area with respect to Hualcán-III-LLGM of 16% for Hualcán-II-YD; 50% for Hualcán-I-LIA; and 74% for 2003. With respect to 2003, ELAs shifted ~520 m since the Local Last Glacial Maximum (LLGM), ~470 m since a marked late-glacial stage (YD?), ~130 m since the Little Ice Age (LIA) and about ~100 m since 1962. If the changes are exclusively attributed to temperature effects, warming since LLGM can be estimated at some 3°C and since the maximum glacier extent of LIA at about 0.8°C. Such values are rather close to mean global temperature change during the corresponding intervals. Most of the ELA shift since LIA appears to have taken place during recent decades characterized by very rapid glacier shrinkage, although air temperature does not seem to have risen considerably during the last 30 years. These results along with other environmental and social approaches will contribute to a better understanding of impacts from climate change and glacier shrinkage in order to develop adaptation, mitigation and disaster risk reduction strategies in the Peruvian Andes.

Younger Dryas glacial stillstands on the Bolivian Altiplano: pattern and climatic implications

NASA Astrophysics Data System (ADS)

Martin, Léo; Blard, Pierre-Henri; Lave, Jérôme; Premaillon, Melody; Charreau, Julien; Jomelli, Vincent; Brunstein, Daniel

2014-05-01

Modifications of the global climate during the last deglaciation have been characterized by regional reorganization that may have in turn amplified or attenuated the global changes. Notably, the respective influences of the Southern and Northern Hemispheres are poorly understood in the Tropics. This underlines the importance of studying past climate variations in the Tropics, particularly in the poorly documented tropical moutain areas. Cosmogenic exposure dating applied to the glacial landscapes provides temporal constraints on glacier fluctuations in response of climate variations. This permits high-resolution reconstructions of regional climates. In this work we present new cosmogenic ages from two different locations of the Bolivian Altiplano, the Nevado Sajama volcano (S18.11° - W66.88°) and the Zongo Valley (S16.25°- W68.11°). On the Sajama, new cosmogenic 3He dates support a late local glacial maximum, synchronous with the plaeolake Tauca highstand (ca. 16 ka) and contemporary to the north Atlantic Heinrich 1 (H1) event, with an equilibrium line altitude (ELA) at ca. 5200 m. Our data document also several recession episodes with the youngest one, characterized by an ELA of 5350 m, that seems to correspond to the Younger Dryas (YD) stadial (ca. 12 ka). In the Zongo valley, two recessional moraines have indistinguishable cosmogenic 10Be ages of ca. 17 ka, synchronous with the transgression of the Lake Tauca, with respective ELA of 4760 and 4640 m. Upstream, we identified an intermediate recessional moraine that could either be synchronous with Heinrich 1 or with the Antarctic Cold Reversal episode. Upward along the valley, a Younger Dryas stadial is clearly established by well-clustered cosmogenic 10Be ages, yielding a moraine age of ca. 12 ka, contemporary with the paleolake Coipasa highstand, with an ELA of 5000 m. These results confirm the sensitivity of South Hemisphere tropical glaciers to North Atlantic climate events, such as H1 or the YD. These glacial stadials are probably strongly driven by the wet conditions that prevailed during the central Altiplano palaeolake episodes. The identification of a Younger Dryas stadial in the Zongo valley, and also probably on the Sajama and Tunupa volcanoes (dating dupliquates are still in progress), is an unprecedented report in this region. During the YD event, the ELAs were ~150m (Sajama) to ~300 m (Tunupa, Zongo valley) higher than during the H1 event. Whereas glaciers advances and paleolake data indicate that the YD in the tropical Altiplano was characterized by higher temperature and lower precipitation than during H1, the climatic conditions during the YD in the Southern Tropics must have been far colder and wetter than today. Indeed, present day ELAs are more than 400 m higher in the Zongo, and more than 600 m higher in the Sajama and the Tunupa than they were during the Younger Dryas.

Effects of Atomic Oxygen and Grease on Outgassing and Adhesion of Silicone Elastomers for Space Applications

NASA Astrophysics Data System (ADS)

de Groh, Henry C.; Puleo, Bernadette J.; Steinetz, Bruce M.

An investigation of silicone elastomers for seals used in docking and habitat systems for future space exploration vehicles is being conducted at NASA. For certain missions, NASA is considering androgynous docking systems where two vehicles each having a seal would be required to: dock for a period of time, seal effectively, and then separate with minimum push-off forces for undocking. Silicone materials are generally chosen for their wide operating temperatures and low leakage rates. However silicone materials are often sticky and usually exhibit considerable adhesion when mated against metals and silicone surfaces. This paper investigates the adhesion unit pressure for a space rated silicone material (S0383-70) for either seal-on-seal (SoS) or seal-on-aluminum (SoAl) operation modes in the following conditions: as-received, after ground-based atomic-oxygen (AO) pre-treatment, after application of a thin coating of a space-qualified grease (Braycote 601EF), and after a combination of AO pre-treatment and grease coating. In order of descending adhesion reduction, the AO treatment reduced seal adhesion the most, followed by the AO plus grease pre-treatment, followed by the grease treatment. The effects of various treatments on silicone (S0383-70 and ELA-SA-401) outgassing properties were also investigated. The leading adhesion AO pre-treatment reduction led to a slight decrease in outgassing for the S0383-70 material and virtually no change in ELA-SA-401 outgassing.

Effects of Atomic Oxygen and Grease on Outgassing and Adhesion of Silicone Elastomers for Space Applications

NASA Technical Reports Server (NTRS)

deGroh, Henry C., III; Puleo, Bernadette J.; Steinetz, Bruce M.

2011-01-01

An investigation of silicone elastomers for seals used in docking and habitat systems for future space exploration vehicles is being conducted at NASA. For certain missions, NASA is considering androgynous docking systems where two vehicles each having a seal would be required to: dock for a period of time, seal effectively, and then separate with minimum push-off forces for undocking. Sili-cone materials are generally chosen for their wide operating temperatures and low leakage rates. However silicone materials are often sticky and usually exhibit considerable adhesion when mated against metals and silicone surfaces. This paper investigates the adhesion unit pressure for a space rated silicone material (S0383-70) for either seal-on-seal (SoS) or seal-on-aluminum (SoAl) operation modes in the following conditions: as-received, after ground-based atomic-oxygen (AO) pre-treatment, after application of a thin coating of a space-qualified grease (Bray-cote 601EF), and after a combination of AO pre-treatment and grease coating. In order of descending adhesion reduction, the AO treatment reduced seal adhesion the most, followed by the AO plus grease pre-treatment, followed by the grease treatment. The effects of various treatments on silicone (S0383-70 and ELA-SA-401) outgassing properties were also investigated. The leading adhesion AO pre-treatment reduction led to a slight decrease in outgassing for the S0383-70 material and virtually no change in ELA-SA-401 outgassing.

Effects of Atomic Oxygen and Grease on Outgassing and Adhesion of Silicone Elastomers for Space Applications

NASA Technical Reports Server (NTRS)

deGroh, Henry C., III; Puleo, Bernadette J.; Steinetz, Bruce M.

2012-01-01

An investigation of silicone elastomers for seals used in docking and habitat systems for future space exploration vehicles is being conducted at NASA. For certain missions, NASA is considering androgynous docking systems where two vehicles each having a seal would be required to: dock for a period of time, seal effectively, and then separate with minimum push-off forces for undocking. Silicone materials are generally chosen for their wide operating temperatures and low leakage rates. However silicone materials are often sticky and usually exhibit considerable adhesion when mated against metals and silicone surfaces. This paper investigates the adhesion unit pressure for a space rated silicone material (S0383-70) for either seal-on-seal (SoS) or seal-on-aluminum (SoAl) operation modes in the following conditions: as-received, after ground-based atomic-oxygen (AO) pre-treatment, after application of a thin coating of a space-qualified grease (Braycote 601EF), and after a combination of AO pre-treatment and grease coating. In order of descending adhesion reduction, the AO treatment reduced seal adhesion the most, followed by the AO plus grease pre-treatment, followed by the grease treatment. The effects of various treatments on silicone (S0383-70 and ELA-SA-401) outgassing properties were also investigated. The leading adhesion AO pretreatment reduction led to a slight decrease in outgassing for the S0383-70 material and virtually no change in ELA-SA-401 outgassing.

Ion channels involved in cell volume regulation: effects on migration, proliferation, and programmed cell death in non adherent EAT cells and adherent ELA cells.

PubMed

Hoffmann, Else Kay

2011-01-01

This mini review outlines studies of cell volume regulation in two closely related mammalian cell lines: nonadherent Ehrlich ascites tumour cells (EATC) and adherent Ehrlich Lettre ascites (ELA) cells. Focus is on the regulatory volume decrease (RVD) that occurs after cell swelling, the volume regulatory ion channels involved, and the mechanisms (cellular signalling pathways) that regulate these channels. Finally, I shall also briefly review current investigations in these two cell lines that focuses on how changes in cell volume can regulate cell functions such as cell migration, proliferation, and programmed cell death. Copyright © 2011 S. Karger AG, Basel.

Exploration Laboratory Analysis - ARC

NASA Technical Reports Server (NTRS)

Krihak, Michael K.; Fung, Paul P.

2012-01-01

The Exploration Laboratory Analysis (ELA) project supports the Exploration Medical Capability (ExMC) risk, Risk of Inability to Adequately Treat an Ill or Injured Crew Member, and ExMC Gap 4.05: Lack of minimally invasive in-flight laboratory capabilities with limited consumables required for diagnosing identified Exploration Medical Conditions. To mitigate this risk, the availability of inflight laboratory analysis instrumentation has been identified as an essential capability in future exploration missions. Mission architecture poses constraints on equipment and procedures that will be available to treat evidence-based medical conditions according to the Space Medicine Exploration Medical Conditions List (SMEMCL). The SMEMCL provided diagnosis and treatment for the evidence-based medical conditions and hence, a basis for developing ELA functional requirements.

Recent glacier retreat over Kerguelen archipelago (49°S, 69°E) derived from field data, satellite imagery and modelling

NASA Astrophysics Data System (ADS)

Verfaillie, Deborah; Favier, Vincent; Dumont, Marie; Jomelli, Vincent; Gilbert, Adrien; Brunstein, Daniel; Frenot, Yves

2013-04-01

Situated in the Indian Ocean at 49° S, 69° E, Kerguelen archipelago represents a unique sub-polar observational site. Located at low altitude and on islands, the glaciers are particularly sensitive to oceanic and atmospheric variations (e.g. Poggi, 1977a,b; Vallon, 1987). The cryosphere on Kerguelen showed important fluctuations during the last 2 centuries (Frenot et al., 1993). After a small stable period until 1961, the ice cap showed a huge and extremely quick retreat, losing 20% of its surface during the last 40 years (Berthier et al., 2009). Relating directly this acceleration with the fluctuations of temperature and precipitation inferred from direct meteorological measurements is attractive and was generally performed (e.g. Frenot et al., 1993, 1997; Berthier et al., 2009). However, it was recently discovered that the drastic temperature change may be mainly due to changes in meteorological station characteristics in 1973 (Météo France, personal communication), challenging previous interpretation. The analysis of field data collected on Ampere glacier since 2010 presented here provides a first approach in our aim to understand the recent rapid retreat of its cryosphere. In this area, short term mass balance data from previous studies (Vallon 1977a,b, 1987) were compared to recent mass balance measurements. The analysis revealed that the spatial distribution of SMB significantly changed in 40 years. Collecting spatially distributed data of the surface characteristics and ablation was crucial to better interpret our field data. Recent variations (from 2000 to 2012) of the equilibrium line altitude (ELA) of Cook ice cap derived from MODIS imagery confirmed that the ELA rose about 100m since 2000. Additionally, we analysed meteorological and reanalysis data over Kerguelen from 1950 to 2012, in order to assess the causes and processes involved in the retreat of the ice cap, and present additional SMB and ELA estimates from a simple positive degree-day model. We concluded that the parameter with the largest variation was precipitation, which was associated to a decrease in cloud cover. The direct impact of these changes was a rise of the 0°C level that led to a reduction of the occurrence of solid precipitation at low elevation. These retroactions demonstrate that Kerguelen's glaciers are extremely sensitive to small climatic changes. These results on glaciological processes of Ampere glacier are an important base to constrain modelling approaches to assess past, present and future ice cap variations. In this framework, regional scale simulations of mass balance processes over Kerguelen archipelago have been initiated with a downscaling scheme (SMHiL) and with the regional climate model MAR (Modèle Atmosphérique Régional).

Spatial Preference Modelling for equitable infrastructure provision: an application of Sen's Capability Approach

NASA Astrophysics Data System (ADS)

Wismadi, Arif; Zuidgeest, Mark; Brussel, Mark; van Maarseveen, Martin

2014-01-01

To determine whether the inclusion of spatial neighbourhood comparison factors in Preference Modelling allows spatial decision support systems (SDSSs) to better address spatial equity, we introduce Spatial Preference Modelling (SPM). To evaluate the effectiveness of this model in addressing equity, various standardisation functions in both Non-Spatial Preference Modelling and SPM are compared. The evaluation involves applying the model to a resource location-allocation problem for transport infrastructure in the Special Province of Yogyakarta in Indonesia. We apply Amartya Sen's Capability Approach to define opportunity to mobility as a non-income indicator. Using the extended Moran's I interpretation for spatial equity, we evaluate the distribution output regarding, first, `the spatial distribution patterns of priority targeting for allocation' (SPT) and, second, `the effect of new distribution patterns after location-allocation' (ELA). The Moran's I index of the initial map and its comparison with six patterns for SPT as well as ELA consistently indicates that the SPM is more effective for addressing spatial equity. We conclude that the inclusion of spatial neighbourhood comparison factors in Preference Modelling improves the capability of SDSS to address spatial equity. This study thus proposes a new formal method for SDSS with specific attention on resource location-allocation to address spatial equity.

Equilibrium-line altitude during the Antarctic Cold Reversal at Río Tranquilo glacier (47°S), Central Patagonia

NASA Astrophysics Data System (ADS)

Sagredo, E. A.; Ward, D.; Gonzalez, M. A.; Lowell, T. V.; Kelly, M. A.; Aravena, J. C.

2013-12-01

Documenting the magnitude of former glacial fluctuations is critical for understanding the mechanisms and climate signals underlying these glacial events. Here, we estimate the equilibrium line altitudes (ELA) associated with the most prominent glacial advance occurred during the Last Glacial Termination (T1) at Tranquilo glacier (47°S). Geomorphic evidence suggest that, following the Last Glacial Maximum, several small glaciers, which today occupy the headwalls of Río Tranquilo valley, expanded and coalesced, forming the extended version of the Tranquilo glacier at least three different times. 10Be ages suggest that the most prominent of these glacial advances occurred ~13 kyr BP, at the end of the Antarctic Cold Reversal (ACR). Based on glacial geomorphic mapping and the application of a glaciological model (GC2D), we reconstruct the former glacial surface at Tranquilo glacier and estimate the ELA for this major glacial advance. Preliminary data show that the equilibrium line altitude at Tranquilo glacier during the ACR could have been up to 500 m lower than the present. This study represents the first effort to quantify the ELA during the Antarctic Cold Reversal in Patagonia, and provides a baseline to decipher the climatic signals driving this glacial event.

Errorless learning of prospective memory tasks: An experimental investigation in people with memory disorders

PubMed Central

Fish, Jessica E.; Manly, Tom; Kopelman, Michael D.; Morris, Robin G.

2015-01-01

The term prospective memory (PM) refers to memory for future intentions. PM problems are frequent in people with cognitive impairment and, because they are central to the realisation of many everyday goals, are important in rehabilitation. Event-based PM tasks (EBPM) are environmentally-cued and have primarily mnemonic demands, whereas time-based PM tasks (TBPM) require self-initiated retrieval, and have greater executive demands. Errorless learning (EL) is an encoding method that results in superior retrospective memory compared with “errorful” learning (EF). As this EL advantage (ELA) likely stems from its reduced explicit memory demands, and there is no such advantage for executive tasks, a greater ELA for EBPM than TBPM was predicted. Fourteen adults with neurological memory impairment completed PM tasks under four counterbalanced conditions: EL of EBPM, EL of TBPM, EF of EBPM, and EF of TBPM. A significant ELA was observed for EBPM (d = .63), but not TBPM (d = –.01). These results extend the evidence for EL within cognitive rehabilitation, by showing for the first time that the method can benefit future action in addition to retrospective memory. The clinical implications are also clear: errorless learning techniques may be usefully employed to support completion of day-to-day EBPM tasks. PMID:24894460

Progressive glacial retreat in the Southern Altiplano (Uturuncu volcano, 22°S) between 65 and 14 ka constrained by cosmogenic 3He dating

NASA Astrophysics Data System (ADS)

Blard, Pierre-Henri; Lave, Jérôme; Farley, Kenneth A.; Ramirez, Victor; Jimenez, Nestor; Martin, Léo C. P.; Charreau, Julien; Tibari, Bouchaïb; Fornari, Michel

2014-07-01

This work presents the first reconstruction of late Pleistocene glacier fluctuations on Uturuncu volcano, in the Southern Tropical Andes. Cosmogenic 3He dating of glacial landforms provides constraints on ancient glacier position between 65 and 14 ka. Despite important scatter in the exposure ages on the oldest moraines, probably resulting from pre-exposure, these 3He data constrain the timing of the moraine deposits and subsequent glacier recessions: the Uturuncu glacier may have reached its maximum extent much before the global LGM, maybe as early as 65 ka, with an equilibrium line altitude (ELA) at 5280 m. Then, the glacier remained close to its maximum position, with a main stillstand identified around 40 ka, and another one between 35 and 17 ka, followed by a limited recession at 17 ka. Then, another glacial stillstand is identified upstream during the late glacial period, probably between 16 and 14 ka, with an ELA standing at 5350 m. This stillstand is synchronous with the paleolake Tauca highstand. This result indicates that this regionally wet and cold episode, during the Heinrich 1 event, also impacted the Southern Altiplano. The ELA rose above 5450 m after 14 ka, synchronously with the Bolling-Allerod.

Control of the dipole layer of polar organic molecules adsorbed on metal surfaces via different charge-transfer channels

NASA Astrophysics Data System (ADS)

Lin, Meng-Kai; Nakayama, Yasuo; Zhuang, Ying-Jie; Su, Kai-Jun; Wang, Chin-Yung; Pi, Tun-Wen; Metz, Sebastian; Papadopoulos, Theodoros A.; Chiang, T.-C.; Ishii, Hisao; Tang, S.-J.

2017-02-01

Organic molecules with a permanent electric dipole moment have been widely used as a template for further growth of molecular layers in device structures. Key properties of the resulting organic films such as energy level alignment (ELA), work function, and injection/collection barrier are linked to the magnitude and direction of the dipole moment at the interface. Using angle-resolved photoemission spectroscopy (ARPES), we have systematically investigated the coverage-dependent work function and spectral line shapes of occupied molecular energy states (MESs) of chloroaluminium-phthalocyanine (ClAlPc) grown on Ag(111). We demonstrate that the dipole orientation of the first ClAlPc layer can be controlled by adjusting the deposition rate and postannealing conditions, and we find that the ELA at the interface differs by ˜0.4 eV between the Cl up and down configurations of the adsorbed ClAlPc molecules. These observations are rationalized by density functional theory (DFT) calculations based on a realistic model of the ClAlPc/Ag(111) interface, which reveal that the different orientations of the ClAlPc dipole layer lead to different charge-transfer channels between the adsorbed ClAlPc and Ag(111) substrate. Our findings provide a useful framework toward method development for ELA tuning.

A conserved segmental duplication within ELA.

PubMed

Brinkmeyer-Langford, C L; Murphy, W J; Childers, C P; Skow, L C

2010-12-01

The assembled genomic sequence of the horse major histocompatibility complex (MHC) (equine lymphocyte antigen, ELA) is very similar to the homologous human HLA, with the notable exception of a large segmental duplication at the boundary of ELA class I and class III that is absent in HLA. The segmental duplication consists of a ∼ 710 kb region of at least 11 repeated blocks: 10 blocks each contain an MHC class I-like sequence and the helicase domain portion of a BAT1-like sequence, and the remaining unit contains the full-length BAT1 gene. Similar genomic features were found in other Perissodactyls, indicating an ancient origin, which is consistent with phylogenetic analyses. Reverse-transcriptase PCR (RT-PCR) of mRNA from peripheral white blood cells of healthy and chronically or acutely infected horses detected transcription from predicted open reading frames in several of the duplicated blocks. This duplication is not present in the sequenced MHCs of most other mammals, although a similar feature at the same relative position is present in the feline MHC (FLA). Striking sequence conservation throughout Perissodactyl evolution is consistent with a functional role for at least some of the genes included within this segmental duplication. © 2010 The Authors, Journal compilation © 2010 Stichting International Foundation for Animal Genetics.

The Association between Health Behaviours and Academic Performance in Canadian Elementary School Students: A Cross-Sectional Study

PubMed Central

McIsaac, Jessie-Lee D.; Kirk, Sara F. L.; Kuhle, Stefan

2015-01-01

Background: Establishing early healthy eating and physical activity behaviours is critical in supporting children’s long-term health and well-being. The objective of the current paper was to examine the association between health behaviours and academic performance in elementary school students in a school board in Nova Scotia, Canada. Methods: Our population-based study included students in grades 4–6 across 18 schools in a rural school board. Diet and physical activity were assessed through validated instruments. Academic performance measures were obtained from the school board for Mathematics and English Language Arts (ELA). Associations between health behaviours and academic performance were assessed using multilevel logistic regression. Results: Students with unhealthy lifestyle behaviours were more likely to have poor academic performance for both ELA and Mathematics compared to students with healthy lifestyle behaviours; associations were statistically significant for diet quality, physical activity, sugar-sweetened beverage consumption for ELA; and breakfast skipping, not being physically active at morning recess, and not being physically active after school for Mathematics. The effects of diet and physical activity were independent of each other and there was no interaction between the two exposures. Conclusions: Our findings suggest that support for healthy behaviours may help to improve academic outcomes of students. PMID:26610537

NASA Laboratory Analysis for Manned Exploration Missions

NASA Technical Reports Server (NTRS)

Krihak, Michael (Editor); Shaw, Tianna

2014-01-01

The Exploration Laboratory Analysis (ELA) project supports the Exploration Medical Capability Element under the NASA Human Research Program. ELA instrumentation is identified as an essential capability for future exploration missions to diagnose and treat evidence-based medical conditions. However, mission architecture limits the medical equipment, consumables, and procedures that will be available to treat medical conditions during human exploration missions. Allocated resources such as mass, power, volume, and crew time must be used efficiently to optimize the delivery of in-flight medical care. Although commercial instruments can provide the blood and urine based measurements required for exploration missions, these commercial-off-the-shelf devices are prohibitive for deployment in the space environment. The objective of the ELA project is to close the technology gap of current minimally invasive laboratory capabilities and analytical measurements in a manner that the mission architecture constraints impose on exploration missions. Besides micro gravity and radiation tolerances, other principal issues that generally fail to meet NASA requirements include excessive mass, volume, power and consumables, and nominal reagent shelf-life. Though manned exploration missions will not occur for nearly a decade, NASA has already taken strides towards meeting the development of ELA medical diagnostics by developing mission requirements and concepts of operations that are coupled with strategic investments and partnerships towards meeting these challenges. This paper focuses on the remote environment, its challenges, biomedical diagnostics requirements and candidate technologies that may lead to successful blood/urine chemistry and biomolecular measurements in future space exploration missions. SUMMARY The NASA Exploration Laboratory Analysis project seeks to develop capability to diagnose anticipated space exploration medical conditions on future manned missions. To achieve this goal, NASA will leverage existing point-of-care technology to provide clinical laboratory measurements in space. This approach will place the project on a path to minimize sample, reagent consumption, mass, volume and power. For successful use in the space environment, NASA specific conditions such as micro gravity and radiation, for example, will also need to be addressed.

Analysis of implantable defibrillator longevity under clinical circumstances: implications for device selection.

PubMed

Knops, Paul; Theuns, Dominic A M J; Res, Jan C J; Jordaens, Luc

2009-10-01

Information about implantable cardioverter-defibrillator (ICD) longevity is mostly calculated from measurements under ideal laboratory conditions. However, little information about longevity under clinical circumstances is available. This survey gives an overview on ICD service times and generator replacements in a cohort of consecutive ICD patients. Indications for replacement were classified as a normal end-of-service (EOS), premature EOS, system malfunction, infection and device advisory, or recall actions. From the premature and normal EOS group, longevity from single-chamber (SC), dual-chamber (DC), and cardiac resynchronization therapy defibrillator (CRT-D), rate-responsive (RR) settings, high output (HO) stimulation, and indication for ICD therapy was compared. Differences between brands were compared as well. In a total of 854 patients, 203 ICD replacements (165 patients) were recorded. Premature and normal EOS replacements consisted of 32 SC, 98 DC and 24 CRT-D systems. Longevity was significantly longer in SC systems compared to DC and CRT-D systems (54 +/- 19 vs. 40 +/- 17 and 42 +/- 15 months; P = 0.008). Longevity between non-RR (n = 143) and RR (n = 11) settings was not significantly different (43 +/- 18 vs. 45 +/- 13 months) as it also was not for HO versus non-HO stimulation (43 +/- 19 vs. 46 +/- 17 months). Longevity of ICDs was not significantly different between primary and secondary prevention (42 +/- 19 vs. 44 +/- 18 months). The average longevity on account of a device-based EOS message was 43 +/- 18 months. Average longevity for Biotronik (BIO, n = 72) was 33 +/- 10 months, for ELA Medical (ELA, n = 12) 44 +/- 17 months, for Guidant (GDT, n = 36) 49 +/- 12 months, for Medtronic (MDT, n = 29) 62 +/- 22 months, and for St. Jude Medical (SJM, n = 5) 31 +/- 9 months (P < 0.001). SC ICD generators had a longer service time compared to DC and CRT-D systems. No influence of indication for ICD therapy and HO stimulation on generator longevity was observed in this study. MDT ICDs had the longest service time.

Hypsometry of lobate debris aprons on the eastern rim of Hellas Basin, Mars: Implications for climate variations

NASA Astrophysics Data System (ADS)

Rutledge, A. M.; Christensen, P. R.

2010-12-01

Geologic features on the surface of Mars show clear evidence of modification by water and water ice at various intervals in the planet’s history. Several studies have demonstrated that buried water ice most likely remains today beneath tens of centimeters of soil. Past obliquity variations are theorized to have promoted the formation and stability of ground ice near the equator, allowing the accumulation of glaciers in the midlatitudes. Potential glacial features, such as lobate debris aprons (LDA) and hourglass craters containing flow features, have also been observed on the eastern rim of Hellas Basin, ranging from latitudes of 30°S to 60°S. LDAs originate at the base of steep massifs and are characterized by lobes of gently sloping, convex-upward surfaces with relatively steep outer margins. The flow-like morphology of these features, including radial and concentric lineations, suggest these features were formed by viscous flow processes. A study targeting the Hellas LDAs by the shallow radar (SHARAD) instrument aboard the Mars Reconnaissance Orbiter (MRO) returned results consistent with massive ice deposits, supporting the hypothesis that these are debris-covered glaciers. These probable glaciers are most likely large reservoirs of present-day, near-surface ice, with implications for global hydrologic cycle modeling, astrobiology studies, and the search for resources in the Solar System. Terrestrial glaciology uses the hypsometric curve, or the empirical cumulative distribution function of elevations, as one method to evaluate parameters such as equilibrium line altitude (ELA) and mass balance of a glacier. ELA is the position, or elevation, at which accumulation is balanced by ablation. Mass balance, the difference between accumulation and ablation, is crucial to the survival of a glacier over time. Both these parameters are closely related to temperature and precipitation and can thus can serve as key indicators of climate change. We apply terrestrial glaciology inventory methods to the lobate debris aprons on the eastern rim of Hellas Basin, Mars to complete a detailed volumetric inventory of the buried ice deposits and to evaluate the hypsometric curve of each feature. We then examine the relationship between LDA hypsometry and latitude in order to understand the effect of past climatic variations on present-day ice distribution. The Thermal Emission Imaging System (THEMIS) Day IR 100m Global Mosaic was used as a base map to determine areal extent, and Mars Orbiter Laser Altimeter (MOLA) data was used to ascertain elevations. Initial results show that, at latitudes at or greater than 45°S, LDAs exhibit hypsometric curves similar to classic terrestrial alpine glaciers - that is, the curve is steep at the upper and lower boundaries, and flattens in the midsection. This type of curve is indicative of a typical glacier with both accumulation and ablation zones, and could potentially be used to determine the - probably defunct - ELA of a lobate debris apron. LDAs at latitudes closer to the equator exhibit atypical hypsometric curves. This change in hypsometry with latitude potentially signals a past shift in temperature and precipitation dependent on latitude.

Central nervous system involvement in severe congenital neutropenia: neurological and neuropsychological abnormalities associated with specific HAX1 mutations.

PubMed

Carlsson, G; van't Hooft, I; Melin, M; Entesarian, M; Laurencikas, E; Nennesmo, I; Trebińska, A; Grzybowska, E; Palmblad, J; Dahl, N; Nordenskjöld, M; Fadeel, B; Henter, J-I

2008-10-01

Homozygous mutations in the HAX1 gene were recently identified in severe congenital neutropenia patients belonging to the original Kostmann family in northern Sweden. Our observations suggested that these patients also develop neurological and neuropsychological symptoms. Detailed clinical studies and mutation analyses were performed in the surviving patients belonging to the Kostmann kindred and in two patients not related to this family, along with studies of HAX1 splice variant expression in normal human tissues. Five of six Kostmann family patients and one other patient from northern Sweden harboured homozygous HAX1 mutations (568C-->T, Q190X) and one carried a heterozygous ELA2 gene mutation. One Swedish patient of Kurdish extraction carried alternative homozygous HAX1 mutations (131G-->A, W44X). All the three patients with Q190X mutations who were alive and available for evaluation developed neurological disease with decreased cognitive function, and three of four patients who reached 10 years developed epilepsy. In contrast, the patients with the ELA2 and W44X HAX1 mutations, respectively, showed no obvious neurological abnormalities. Moreover, two alternative HAX1 splice variants were identified in normal human tissues, including the brain. Both transcripts contained exon 5, harbouring the Q190X mutation, whereas the 5' end of exon 2 containing the W44X mutation was spliced out from the second transcript. We describe neurological and neuropsychological abnormalities for the first time in Kostmann disease patients. These central nervous system symptoms appear to be associated with specific HAX1 mutations.

42 CFR 447.502 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... NDA and a covered outpatient drug approved under a product license approval (PLA), establishment... covered outpatient drug approved under a biological license application, PLA, ELA, or ADA. States means...

Excimer laser annealing for low-voltage power MOSFET

NASA Astrophysics Data System (ADS)

Chen, Yi; Okada, Tatsuya; Noguchi, Takashi; Mazzamuto, Fulvio; Huet, Karim

2016-08-01

Excimer laser annealing of lumped beam was performed to form the P-base junction for high-performance low-voltage-power MOSFET. An equivalent shallow-junction structure for the P-base junction with a uniform impurity distribution is realized by adopting excimer laser annealing (ELA). The impurity distribution in the P-base junction can be controlled precisely by the irradiated pulse energy density and the number of shots of excimer laser. High impurity activation for the shallow junction has been confirmed in the melted phase. The application of the laser annealing technology in the fabrication process of a practical low-voltage trench gate MOSFET was also examined.

Time Lapse Camera Images for Observation and Visualization of Snow Lines on two Benchmark Glaciers in High Asia - Zhadang and Halji

NASA Astrophysics Data System (ADS)

Schröter, B.; Buchroithner, M. F.; Pieczonka, T.

2015-12-01

Glaciers are characteristic elements of high mountain environments and represent key indicators for the ongoing climate change. The covering snowpack considerably affects the glacier-ice surface temperature and thus the meltdown of the glaciers which in recent decades has been accelerating worldwide. Therefore, the detailed investigation of the transient snow is of high importance. Zhadang Glacier is located in the Nyainqentanglha Mountain Range on the central part of the Tibetan Plateau (30°28.24' N, 90°38.69' E). The glacier is debris-free and flows from 6,090 to 5,515 m a.s.l. Recent measurements have shown that the whole glacier is below the ELA and experiences significant glacier volume loss. In May 2010 two terrestrial cameras had been installed there and were continuously operating until September 2012 generating 6,225 images of the glacier with a frequency of three resp. six images per day. In order to use this dataset for snow line mapping all images had to be georeferenced and orthorectified. The biggest challenge was the problem of shifting camera positions due to deformations of the ground and hence the offset in the image coordinates. This was resolved by combining the manual orthorectification of one image per week with a subsequent spline interpolation to determine the changed image coordinates. The actual orthorectification was finally realized by applying a fully automated batch processing of all images. The most favorable image of each day was chosen for the manual snow line mapping process. The final aim was the calculation of the mean elevation of the snow line for every day of the data collecting period materialized by intersecting the mapped snow lines with resampled SRTM 3 data. Considering the fact that there were several weeks either with full snow cover or without any snow this aim could be achieved. The findings have been used for the evaluation of a glacier mass balance model developed at RWTH Aachen, Germany, showing a high level of congruence. Another result is the proof of intense ablation due to snow drift and sublimation during the winter months. In 2014 a similar camera system was installed near Halji Glacier in northwestern Nepal on the southern edge of the Tibetan Plateau (30°15.80' N, 81°28.16' E; 5,730 - 5,270 m a.s.l.; ELA = 5,660 m a.s.l.). The images are currently being processed.

Timing and nature of Holocene glacier advances at the northwestern end of the Himalayan-Tibetan orogen

NASA Astrophysics Data System (ADS)

Saha, Sourav; Owen, Lewis A.; Orr, Elizabeth N.; Caffee, Marc W.

2018-05-01

Holocene glacial chronostratigraphies are developed for four glaciated valleys at the northwestern end of the Himalayan-Tibetan orogen using geomorphic mapping and cosmogenic 10Be surface exposure dating. The study areas include the Hamtah valley in the Lahul Himalaya, and the Karzok, Lato and upper Stok valleys in Zanskar. Five local glacial stages are dated to ∼10.4, ∼6.1-3.3, ∼2.1-0.9, ∼0.7-0.4, and ∼0.3-0.2 ka based on 49 new moraine boulder ages. Large age dispersions are evident for each of the local glacial stages. This is especially the case for ∼6.1-3.3 and ∼2.1-0.9 ka, which is likely a result of prior and/or incomplete exposures in very young moraine boulders. An additional compilation of 187 published 10Be moraine boulder ages help define seven Himalayan Holocene regional glacial stages (HHs) for the northwestern end of the Himalayan-Tibetan orogen. These HHs date to ∼10.9-9.3, ∼8.2-7.4, ∼6.9-4.3, ∼4.5-2.8, ∼2.7-1.8, ∼1.8-0.9, and <1 ka. Early Holocene glacier advances were generally more extensive and had larger equilibrium-line altitude depressions (ΔELA = ∼425 ± 229 m) than glacier advances during the mid-Holocene (ΔELA = ∼141 ± 106) and late Holocene (ΔELA = ∼124 ± 121 m). The early Holocene glacier advances likely correspond to orbitally-forced northerly migration of the Intertropical Convergence Zone and enhanced summer monsoon. The timing of the majority of HHs during mid- and late Holocene corresponds well with the North Atlantic cooling that is likely teleconnected via mid-latitude westerlies, particularly during ∼8 ka and after ∼5 ka. These chronostratigraphies suggest that Holocene glaciation in the northwestern part of the Himalayan-Tibetan orogen is largely influenced by long-term orbital forcing amplified by large-scale migration of the Earth's thermal equator and the associated hemispheric oceanic-atmospheric systems.

Calculation and visualisation of future glacier extent in the Swiss Alps by means of hypsographic modelling

NASA Astrophysics Data System (ADS)

Paul, F.; Maisch, M.; Rothenbühler, C.; Hoelzle, M.; Haeberli, W.

2007-02-01

The observed rapid glacier wastage in the European Alps during the past 20 years already has strong impacts on the natural environment (rock fall, lake formation) as well as on human activities (tourism, hydro-power production, etc.) and poses several new challenges also for glacier monitoring. With a further increase of global mean temperature in the future, it is likely that Alpine glaciers and the high-mountain environment as an entire system will further develop into a state of imbalance. Hence, the assessment of future glacier geometries is a valuable prerequisite for various impact studies. In order to calculate and visualize in a consistent manner future glacier extent for a large number of individual glaciers (> 100) according to a given climate change scenario, we have developed an automated and simple but robust approach that is based on an empirical relationship between glacier size and the steady-state accumulation area ratio (AAR 0) in the Alps. The model requires digital glacier outlines and a digital elevation model (DEM) only and calculates new glacier geometries from a given shift of the steady-state equilibrium line altitude (ELA 0) by means of hypsographic modelling. We have calculated changes in number, area and volume for 3062 individual glacier units in Switzerland and applied six step changes in ELA 0 (from + 100 to + 600 m) combined with four different values of the AAR 0 (0.5, 0.6, 0.67, 0.75). For an AAR 0 of 0.6 and an ELA 0 rise of 200 m (400 m) we calculate a total area loss of - 54% (- 80%) and a corresponding volume loss of - 50% (- 78%) compared to the 1973 glacier extent. In combination with a geocoded satellite image, the future glacier outlines are also used for automated rendering of perspective visualisations. This is a very attractive tool for communicating research results to the general public. Our study is illustrated for a test site in the Upper Engadine (Switzerland), where landscape changes above timberline play an important role for the local economy. The model is seen as a first-step approach, where several parts can be (and should be) further developed.

Chronic health conditions and school performance among children and youth.

PubMed

Crump, Casey; Rivera, Diana; London, Rebecca; Landau, Melinda; Erlendson, Bill; Rodriguez, Eunice

2013-04-01

Chronic health conditions are common and increasing among U.S. children and youth. We examined whether chronic health conditions are associated with low school performance. This retrospective cohort study of 22,730 children and youth (grades 2-11) in San Jose, California, was conducted from 2007 through 2010. Health conditions were defined as chronic if reported in each of the first 2 years, and school performance was measured using standardized English language arts (ELA) and math assessments. Chronic health conditions were independently associated with low ELA and math performance, irrespective of ethnicity, socioeconomic status, or grade level. Adjusted odds ratios for the association between any chronic health condition and low ("basic or below") performance were 1.25 (95% confidence interval [CI], 1.16-1.36; P < .001) for ELA and 1.28 (95% CI, 1.18-1.38; P < .001) for math, relative to students without reported health conditions. Further adjustment for absenteeism had little effect on these results. The strongest associations were found for ADHD, autism, and seizure disorders, whereas a weak association was found for asthma before but not after adjusting for absenteeism, and no associations were found for cardiovascular disorders or diabetes. Chronic neurodevelopmental and seizure disorders, but not cardiovascular disorders or diabetes, were independently associated with low school performance among children and youth. Copyright © 2013 Elsevier Inc. All rights reserved.

Using KrF ELA to Improve Gate-Stacked LaAlO₃/ZrO₂ Indium Gallium Zinc Oxide Thin-Film Transistors with Novel Atmospheric Pressure Plasma-Enhanced Chemical Vapor Deposition Technique.

PubMed

Wu, Chien-Hung; Chang, Kow-Ming; Chen, Yi-Ming; Huang, Bo-Wen; Zhang, Yu-Xin; Wang, Shui-Jinn

2018-03-01

Atmospheric pressure plasma-enhanced chemical vapor deposition (AP-PECVD) technique and KrF excimer laser annealing (ELA) were employed for the fabrication of indium gallium zinc oxide thin-film transistors (IGZO-TFTs). Device with a 150 mJ/cm2 laser annealing densities demonstrated excellent electrical characteristics with improved on/off current ratio of 4.7×107, high channel mobility of 10 cm2/V-s, and low subthreshold swing of 0.15 V/dec. The improvements are attributed to the adjustment of oxygen vacancies in the IGZO channel to an appropriate range of around 28.3% and the reduction of traps at the high-k/IGZO interface.

Geochronology and Equilibrium Line Altitudes of LLGM through Holocene Glaciations from the Tropical Cordillera Huayhuash, Peru

NASA Astrophysics Data System (ADS)

Hall, S. R.; Ramage, J. M.; Rodbell, D. T.; Finkel, R. C.; Smith, J. A.; Mark, B. G.; Farber, D. L.

2006-12-01

Geomorphologic relationships and cosmogenic 10Be ages from the Central Peruvian Andes reveal a rich record of glaciations from at least the late Holocene, Late Glacial, Last Local Glacial Maximum (LLGM), and older more extensive glaciations - dated between 50ka and 440ka in both the Cordillera Blanca, to the north and the Junin Region to the south. The Cordillera Huayhuash (10.3°S, 76.9°W) is located between these two well-studied regions. The spine of the range trends nearly north-south and contains a substantial east-west spur which together can be used to evaluate the spatial variation in paleo-ELAs. The range is thus a key location to study changes in ice extent and equilibrium line altitudes (ELAs) between the LLGM and modern periods. Modern glaciers are confined to altitudes >4800 m and the present (1997) ELA is 4800- 5100m. In order to determine the paleo-ice positions of glaciers in different valleys we have developed a new chronology from cosmogenic 10Be ages of moraine boulder and 14C basal bog core ages. Through field mapping of glacial features, analysis of satellite imagery, digital elevation models (DEMs), and geochronology, we have delineated the ice limits associated with the LLGM, Late Glacial, and Late Holocene advances. Ages in the three valleys we have studied cluster at ~29ka, ~13ka, and ~9ka and overall we have identified surfaces with ages that range from 39.9±1.4ka to 0.2ka±0.05ka. Based on these data, we have mapped the extent of the correlative paleo-glaciers in these three drainages and extracted the modern hypsometry for each paleo-glacier from the DEMs. From this data set, we have generated paleo- ELAs using a range of methods: Toe-to-Headwall-Altitude Ratio (THAR), the Accumulation Area Ratio (AAR), and Accumulation Area Balance Ratio (AABR). For each of the LLGM, Late Glacial and Holocene stages, we have calculated both: (1) the temperature depression assuming no moisture variations, and (2) the potential relative moisture gradients assuming a constant temperature depression. Our results suggest that variations in glacial extent (and therefore paleo-ELAs) are strongly correlated with differences in valley orientation and morphology as eastern drainages receive more moisture and have shallower topographic gradients than western drainages. Additionally, while there is an extensive record of older (>39.9±1.4ka) advances to the north (Cordillera Blanca) and to the south (Junin region), the confined morphology of the Cordillera Huayhaush valleys may have inhibited the preservation of older glacial geomorphologic features, thereby explaining the apparent lack of old moraines in this range.

Electrical Actuation Technology Bridging

NASA Technical Reports Server (NTRS)

Hammond, Monica (Compiler); Sharkey, John (Compiler)

1993-01-01

This document contains the proceedings of the NASA Electrical Actuation Technology Bridging (ELA-TB) Workshop held in Huntsville, Alabama, September 29-October 1, 1992. The workshop was sponsored by the NASA Office of Space Systems Development and Marshall Space Flight Center (MSFC). The workshop addressed key technologies bridging the entire field of electrical actuation including systems methodology, control electronics, power source systems, reliability, maintainability, and vehicle health management with special emphasis on thrust vector control (TVC) applications on NASA launch vehicles. Speakers were drawn primarily from industry with participation from universities and government. In addition, prototype hardware demonstrations were held at the MSFC Propulsion Laboratory each afternoon. Splinter sessions held on the final day afforded the opportunity to discuss key issues and to provide overall recommendations. Presentations are included in this document.

Electrical Actuation Technology Bridging

NASA Astrophysics Data System (ADS)

Hammond, Monica; Sharkey, John

1993-05-01

This document contains the proceedings of the NASA Electrical Actuation Technology Bridging (ELA-TB) Workshop held in Huntsville, Alabama, September 29-October 1, 1992. The workshop was sponsored by the NASA Office of Space Systems Development and Marshall Space Flight Center (MSFC). The workshop addressed key technologies bridging the entire field of electrical actuation including systems methodology, control electronics, power source systems, reliability, maintainability, and vehicle health management with special emphasis on thrust vector control (TVC) applications on NASA launch vehicles. Speakers were drawn primarily from industry with participation from universities and government. In addition, prototype hardware demonstrations were held at the MSFC Propulsion Laboratory each afternoon. Splinter sessions held on the final day afforded the opportunity to discuss key issues and to provide overall recommendations. Presentations are included in this document.

Association between the Prevalence of Indigestible Foreign Objects in the Gastrointestinal Tract of Slaughtered Cattle and Body Condition Score

PubMed Central

Nongcula, Vikhaya Vincent; Zhou, Leocadia

2017-01-01

Simple Summary The South African national cattle herd has increased from 6 million head since the 1970s to 14 million and more than two-thirds of the 14 million cattle in South Africa reside in the Eastern Cape Province (ECP), yet the Province has one of the highest poverty indexes. While this improvement is commendable, there are still many challenges to efficient livestock production notably infectious and non-infectious diseases. Many non-infectious diseases of the fore-stomach, such as rumenitis, rumen parakeratosis, traumatic reticuloperitonitis and poly bezoars, are rarely reported, but are known to obstruct the digestive functions of the fore-stomach, causing a marked reduction in animal weight, reproduction, feed absorption and productivity, and death. The pathogenesis of these diseases often begins with the consumption of indigestible foreign objects (IFOs). Animal husbandry in the ECP is mostly communal, with an extensive system of rearing animals as the most popular production system. This system of rearing animals exposes them to consumption of litter, especially when there is drought. This study provides knowledge on the prevalence, type and effect of the indigestible foreign object on the body condition score of animals slaughtered in the ECP. Abstract It is estimated that South Africa’s population will be above 65 million in 2050. Thus, food production needs to triple to alleviate poverty and food insecurity. However, infectious and non-infectious diseases affect livestock productivity, thereby hampering food supply. Non-infectious disease/conditions caused by the consumption of solid waste material are rarely reported. Hence, this study investigates the occurrence and type of indigestible foreign objects (IFOs) in the stomach of slaughtered cattle in two high-throughput abattoirs (n = 4424) in the Eastern Cape Province of South Africa. The study revealed that metallic and non-metallic indigestible objects had an overall prevalence of 63% in cattle slaughtered in Queenstown abattoir (QTA, (n = 1906)) and 64.8% at the East London abattoir (ELA, (n = 2518)). Most of the IFOs were found in the rumen (64.2% and 70.8%) and reticulum (28.5% and 20.6%) at QTA and ELA respectively. The leading IFOs in the stomach of cattle at QTA were plastics (27.7%), poly bezoars (10.7%) and ropes (10.7%), while poly bezoars (19.8%), ropes (17.6%) and stones (10.7%) were the main IFOs seen in cattle at ELA. The study showed a statistical significance (p < 0.05) between body condition score and the prevalence of indigestible objects in cattle. The study concluded that litter and waste containing IFOs could pose a threat to livestock health and productivity. The practice of good animal husbandry and efficient solid waste management will mitigate the problem of animals consuming IFOs. PMID:29084136

CeREs_VCLS_CubeSat_0002

NASA Image and Video Library

2018-04-10

A host of CubeSats, or small satellites, are undergoing the final stages of processing at Rocket Lab USA’s facility in Huntington Beach, California, for NASA’s first mission dedicated solely to spacecraft of their size. This will be the first launch under the agency’s new Venture Class Launch Services. Scientists, including those from NASA and various universities, began arriving at the facility in early April with spacecraft small enough to be a carry-on to be prepared for launch. A team from NASA’s Goddard Spaceflight Center in Greenbelt, Maryland, completed final checkouts of a CubeSat called the Compact Radiation Belt Explorer (CeREs), before placing the satellite into a dispenser to hold the spacecraft during launch inside the payload fairing. Among its missions, the satellite will examine the radiation belt and how electrons are energized and lost, particularly during events called microbursts — when sudden swarms of electrons stream into the atmosphere. This facility is the final stop for designers and builders of the CubeSats, but the journey will continue for the spacecraft. Rocket Lab will soon ship the satellites to New Zealand for launch aboard the company’s Electron orbital rocket on the Mahia Peninsula this summer. The CubeSats will be flown on an Educational Launch of Nanosatellites (ELaNa) mission to space through NASA’s CubeSat Launch Initiative. CeREs is one of the 10 ELaNa CubeSats scheduled to be a part of this mission.

Effects of Low Earth Orbit on Docking Seal Materials

NASA Technical Reports Server (NTRS)

Imka, Emily C.; Asmar, Olivia C.; deGroh, Henry C., III; Banks, Bruce A.

2014-01-01

Spacecraft docking seals are typically made of silicone elastomers. When such seals are exposed to low Earth orbit (LEO) conditions, they can suffer damage from ultraviolet (UV) radiation and atomic oxygen (AO, or monoatomic oxygen, the predominant oxygen species in LEO). An experiment flew on the International Space Station (ISS) to measure the effects of LEO on seal materials S0383-70 and ELA-SA-401 and various mating counterface materials which included anodized aluminum. Samples flown in different orientations received different amounts of UV and AO. The hypotheses were that most of the damage would be from UV, and 10 days or more of exposure in LEO would badly damage the seals. Eighteen seals were exposed for 543 days in ram (windward), zenith (away from Earth), or wake (leeward) orientations, and 15 control samples (not flown) provided undamaged baseline leakage. To determine post-flight leak rates, each of the 33 seals were placed in an O-ring groove of a leak test fixture and pressure tested over time. Resistance temperature detectors (RTDs), pressure transducers, and LabVIEW (National Instruments) programs were used to measure and analyze the temperature and pressure and calculate leakage. Average leakage of control samples was 2.6 x 10(exp -7) lbs/day. LEO exposure did not considerably damage ELA-SA-401. The S0383-70 flight samples leaked at least 10 times more than ELA-SA-401 in all cases except one, demonstrating that ELA-SA-401 may be a more suitable sealing material in LEO. AO caused greater damage than UV; samples in ram orientation (receiving an AO fluence of 4.3 x 10(exp 21) atoms/(sq cm) and in wake (2.9x 10(exp 20) atoms/(sq cm)) leaked more than those in zenith orientation (1.58 x 10(exp 20) atoms/(sq cm)), whereas variations in UV exposure did not seem to affect the samples. Exposure to LEO did less damage to the seals than hypothesized, and the data did not support the conjecture that UV causes more damage than AO.

Southwest Greenland's Alpine Glacier History: Recent Glacier Change in the Context of the Holocene Geologic Record

NASA Astrophysics Data System (ADS)

Larocca, L. J.; Axford, Y.; Lasher, G. E.; Lee, C. W.

2017-12-01

Due to anthropogenic climate change, the Arctic region is currently undergoing major transformation, and is expected to continue warming much faster than the global average. To put recent and future changes into context, a longer-term understanding of this region's past response to natural climate variability is needed. Given their sensitivity to modest climate change, small alpine glaciers and ice caps on Greenland's coastal margin (beyond the Greenland Ice Sheet) represent ideal features to record climate variability through the Holocene. Here we investigate the Holocene history of a small ( 160 square km) ice cap and adjacent alpine glaciers, located in southwest Greenland approximately 50 km south of Nuuk. We employ measurements on sediment cores from a glacier-fed lake in combination with geospatial analysis of satellite images spanning the past several decades. Sedimentary indicators of sediment source and thus glacial activity, including organic matter abundance, inferred chlorophyll-a content, sediment major element abundances, grain size, and magnetic susceptibility are presented from cores collected from a distal glacier-fed lake (informally referred to here as Per's Lake) in the summer of 2015. These parameters reflect changes in the amount and character of inorganic detrital input into the lake, which may be linked to the size of the upstream glaciers and ice cap and allow us to reconstruct their status through the Holocene. Additionally, we present a complementary record of recent changes in Equilibrium Line Altitude (ELA) for the upstream alpine glaciers. Modern ELAs are inferred using the accumulation area ratio (AAR) method in ArcGIS via Landsat and Worldview-2 satellite imagery, along with elevation data obtained from digital elevation models (DEMs). Paleo-ELAs are inferred from the positions of moraines and trim lines marking the glaciers' most recent expanded state, which we attribute to the Little Ice Age (LIA). This approach will allow us to explore the possibility of quantitatively or qualitatively linking changes in ELA (and thus the size of upstream glaciers) to specific sediment parameters. Ultimately, we aim to reconstruct glacier variability through the entire Holocene epoch, and to compare this history with 20th and 21st Century changes.

Jackson State University's Center for Spatial Data Research and Applications: New facilities and new paradigms

NASA Technical Reports Server (NTRS)

Davis, Bruce E.; Elliot, Gregory

1989-01-01

Jackson State University recently established the Center for Spatial Data Research and Applications, a Geographical Information System (GIS) and remote sensing laboratory. Taking advantage of new technologies and new directions in the spatial (geographic) sciences, JSU is building a Center of Excellence in Spatial Data Management. New opportunities for research, applications, and employment are emerging. GIS requires fundamental shifts and new demands in traditional computer science and geographic training. The Center is not merely another computer lab but is one setting the pace in a new applied frontier. GIS and its associated technologies are discussed. The Center's facilities are described. An ARC/INFO GIS runs on a Vax mainframe, with numerous workstations. Image processing packages include ELAS, LIPS, VICAR, and ERDAS. A host of hardware and software peripheral are used in support. Numerous projects are underway, such as the construction of a Gulf of Mexico environmental data base, development of AI in image processing, a land use dynamics study of metropolitan Jackson, and others. A new academic interdisciplinary program in Spatial Data Management is under development, combining courses in Geography and Computer Science. The broad range of JSU's GIS and remote sensing activities is addressed. The impacts on changing paradigms in the university and in the professional world conclude the discussion.

Characteristics of Elastomer Seals Exposed to Space Environments

NASA Technical Reports Server (NTRS)

Daniels, Christopher C.; deGroh, Henry, III; Dunlap, Patrick H., Jr.; Finkbeiner, Joshua R.; Steinetz, Bruce M.; Bastrzyk, Marta B.; Oswald, Jay J.; Banks, Bruce A.; Dever, Joyce A.; Miller, Sharon K.;

Trieu Mai | NREL

Science.gov Websites

Energy Laboratory. NREL/TP-6A20-52409-1. Brinkman, G., P. Denholm, E. Drury, E. Ela, T. Mai, R. Margolis . Brinkman, E. Drury, M. Mowers, and C. Turchi. 2012. Potential Role of Concentrating Solar Power in Enabling

Erosional Reduction of an Orogenic Wedge: Structural Response to Neogene Climate Change within the St. Elias Orogen, Alaska

NASA Astrophysics Data System (ADS)

Berger, A. L.; Spotila, J. A.; Chapman, J. B.; Pavlis, T. L.; Enkelmann, E.; Buscher, J. T.

2007-12-01

The kinematics and architecture of orogenic systems may be heavily influenced by climate, but little research has focused on the long term effects of glacial erosion on orogenesis. Apatite and zircon (U-Th)/He thermochronometry on >75 bedrock samples across the St. Elias orogen, one of the best examples of a glaciated orogenic wedge, is the basis for a new kinematic model and demonstrates an association between glacial denudation and orogenic architecture. The spatial pattern of low temperature cooling indicates that exhumation and deformation are focused within a thin-skinned fold and thrust belt on the windward flank, whereas the leeward flank of the orogen functions as a deformational backstop. A previously unrecognized structure beneath the Bagley ice field must separate these domains with south-side-up motion. We propose this structure is a backthrust making the orogen doubly-vergent. Suggestive of accelerated backthrust motion in response to climate change, cooling rates within the hanging wall block and across the entire windward flank of the orogen accelerated ten-fold coeval with enhanced glaciation. As backthrust motion increased, glacial unroofing also coincided with a regional shift in deformation away from prominent forethrusts including the North American-Yakutat terrane suture (Chugach St. Elias fault) and the seaward deformation front (Pamplona zone). Across the windward flank of the orogen, exhumation, at rates of up to 5 mm/yr, is focused within a narrow zone, where the glacial equilibrium line altitude (ELA) intersects the orogenic wedge. This zone of rapid exhumation, not present prior to the onset of enhanced glaciation, cuts across the structural trend of the orogen and is more narrowly focused than orographic precipitation. Accelerated denudation at the ELA thus appears to have redistributed strain along a series of forethrusts that lie at the zone of heaviest glacial flux, while the backthrust progressively truncates the southward-vergent forethrusts. In a cause and effect response, the expansion of glaciers therefore appears to have resulted in a narrowing of the orogenic wedge due to increased backthrust motion and a landward propagation of deformation in order to preserve topographic slope. This focusing of long- term glacial erosion and deformation at the ELA matches predictions from analytical models of orogenic wedges (i.e. Tomkin and Braun, 2002) and implies a high degree of coupling between climate and tectonics in this glacially-dominated orogen.

Climatic implications of glacial evolution in the Tröllaskagi peninsula (northern Iceland) since the Little Ice Age maximum. The cases of the Gljúfurárjökull and Tungnahryggsjökull glaciers

NASA Astrophysics Data System (ADS)

Fernández-Fernández, José M.; Andrés, Nuria; Brynjólfsson, Skafti; Sæmundsson, Þorsteinn; Palacios, David

2017-04-01

The Tröllaskagi peninsula is located in northern Iceland, between meridians 19°30'W and 18°10'W, jutting out into the North Atlantic to latitude 66°12'N and joining the central highlands to the south. About 150 glaciers located on the Tröllaskagi peninsula reached their Holocene maximum extent during the Little Ice Age (LIA) maximum at the end of the 19th century. The sudden warming at the turn of the 20th century triggered a continuous retreat from the LIA maximum positions, interrupted by a reversal trend during the mid-seventies and eighties in response to a brief period of climate cooling. The aim of this paper is to analyze the relationships between glacial and climatic evolution since the LIA maximum. For this reason, we selected three small debris-free glaciers: Gljúfurárjökull, and western and eastern Tungnahryggsjökull, at the headwalls of Skíðadalur and Kolbeinsdalur, as their absence of debris cover makes them sensitive to climatic fluctuations. To achieve this purpose, we used ArcGIS to map the glacier extent during the LIA maximum and several dates over four georeferenced aerial photos (1946, 1985, 1994 and 2000), as well as a 2005 SPOT satellite image. Then, the Equilibrium-Line Altitude (ELA) was calculated by applying the Accumulation Area Ratio (AAR) and Area Altitude Balance Ratio (AABR) approaches. Climatological data series from the nearby weather stations were used in order to analyze climate development and to estimate precipitation at the ELA with different numerical models. Our results show considerable changes of the three debris-free glaciers and demonstrates their sensitivity to climatic fluctuations. As a result of the abrupt climatic transition of the 20th century, the following warm 25-year period and the warming started in the late eighties, the three glaciers retreated by ca. 990-1330 m from the LIA maximum to 2005, supported by a 40-metre ELA rise and a reduction of their area and volume of 25% and 33% on average, respectively. The 1.5 °C warming recorded at the city of Akureyri from late 19th century to 2005 does not agree with the 0.3 °C value obtained from the ELA rise and lapse rate. On the contrary it demonstrates that other factors - for example, precipitation and wind - have been decisive in the evolution of the glaciers. All the models applied suggest a precipitation increase of 700 mm water equivalent at the mean ELA since the LIA maximum, and higher and lower values depending on warm and cold periods respectively. The overall increase in precipitation is compatible with the increase in the surface temperature of the North Atlantic and a possible negative-to-positive shift in North Atlantic Oscillation (NAO) mode. However, the link between winter accumulation and prevailing wind directions recorded at nearby weather stations remains unclear. Research funded by Deglaciation project (CGL2015-65813-R), Government of Spain.

Politics and Pragmatics in the Crosscultural Management of "Rapport"

ERIC Educational Resources Information Center

Crawshaw, Robert; Harrison, Julia

2007-01-01

This paper examines the sociopragmatic character of intercultural communication between English Language Assistants (ELAs) and their "mentors" in French primary and secondary schools. With reference to Levinson's notion of "activity type", it argues that judgements by mentors as to what constitutes "allowable…

Sensitivity of glacier mass balance and equilibrium line altitude to climatic change on King George Island, Antarctic Peninsula.

NASA Astrophysics Data System (ADS)

Falk, Ulrike; Lopez, Damian; Silva-Busso, Adrian

2017-04-01

The South Shetland Islands are located at the northern tip of the Antarctic Peninsula which is among the fastest warming regions on Earth. Surface air temperature increases (ca. 3 K in 50 years) are concurrent with retreating glacier fronts, an increase in melt areas, ice surface lowering and rapid break-up and disintegration of ice shelves. Observed surface air temperature lapse rates show a high variability during winter months (standard deviations up to ±1.0 K/100 m), and a distinct spatial heterogeneity reflecting the impact of synoptic weather patterns especially during winter glacial mass accumulation periods. The increased mesocyclonic activity during the winter time in the study area results in intensified advection of warm, moist air with high temperatures and rain, and leads to melt conditions on the ice cap, fixating surface air temperatures to the melting point. The impact on winter accumulation results in even more negative mass balance estimates. Six years of glaciological measurements on mass balance stake transects are used with a glacier melt model to assess changes in melt water input to the coastal waters, glacier surface mass balance and the equilibrium line altitude. The average equilibrium line altitude (ELA) calculated from own glaciological observations for KGI over the time period 2010 - 2015 amounts to ELA=330±100 m. Published studies suggest rather stable condition slightly negative glacier mass balance until the mid 80's with an ELA of approx. 150 m. The calculated accumulation area ratio suggests rather dramatic changes in extension of the inland ice cap for the South Shetland Islands until an equilibrium with concurrent climate conditions is reached.

Measuring past glacier fluctuations from historic photographs geolocated using Structure from Motion

NASA Astrophysics Data System (ADS)

Vargo, L.; Anderson, B.; Horgan, H. J.; Mackintosh, A.; Lorrey, A.; Thornton, M.

2017-12-01

Quantifying glacier fluctuations is important for understanding how the cryosphere responds to climate variability and change. Photographs of past ice extents have become iconic images of climate change, but until now incorporating these images into quantitative estimates of glacier change has been problematic. We present a new method to quantitatively measure past glacier fluctuations from historic images. The method uses a large set of modern geolocated photographs and Structure from Motion (SfM) to calculate the camera parameters for the historic images, including the location from which they were taken. We initially apply this method to a small maritime New Zealand glacier (Brewster Glacier, 44°S, 2 km2), and quantify annual equilibrium line altitudes (ELAs) and length changes from historic oblique aerial photographs (1981 - 2017). Results show that Brewster has retreated 364 ± 12 m since 1981 and, using independent field measurements of terminus positions (2005 - 2014), we show that this SfM-derived length record accurately captures glacier change. We calculate the uncertainties associated with this method using known coordinates of bedrock features surrounding the glacier. Mean uncertainties in the ELA and length records are 7 m and 11 m, respectively. In addition to Brewster, 49 other New Zealand glaciers have been monitored by aerial photographs since 1978. However, the length records for these glaciers only include years of relative advance or retreat, and no length changes have been quantified. We will ultimately apply this method to all 50 glaciers, expanding the database of New Zealand glacier fluctuations that until now included only a few glaciers. This method can be further applied to any glacier with historic images, and can be used to measure past changes in glacier width, area, and surface elevation in addition to ELA and length.

Glacial Buzzcutting and Scarp Encroachment Limit the Height of Tropical Mountains

NASA Astrophysics Data System (ADS)

Cunningham, M.; Stark, C. P.; Kaplan, M. R.; Schaefer, J. M.; Winckler, G.

2016-12-01

In many mountain ranges hypsometric maxima occur between the glacial equilibrium line altitude (ELA) of the Last Glacial Maximum (LGM) and that of today. A common interpretation of this large-scale observation is that a "glacial buzzsaw" acting throughout the Pleistocene concentrated area within the altitudinal band of ELA fluctuation. This hypothesis remains controversial, however, as there are many examples of uplifted relict surfaces in heavily glaciated areas that occur near the ELA by coincidence. We have focused on the role of glacial erosion in the tropics, where it is spatially restricted to high elevations and temporally limited to global glacial maxima, but appears to have nevertheless truncated vertical orogen growth. Evidence of glacial buzzcutting in some of these ranges has been obscured by post-glacial destruction of glacial valleys by expanding fluvial catchments. We deduce that a duel between glacial buzzcuting and fluvially-driven scarp encroachment has proceeded throughout the Pleistocene in these places. In Costa Rica, we use 10Be and 3He surface-exposure age dating and topographic analysis to confirm that substantial glacial denudation took place at high elevations during the LGM, and employ topographic metrics there and in the Central Range of Taiwan to reveal shrinkage of glacially buzzcut surfaces driven by post-glacial scarp encroachment. These data cast new light on the buzzsaw hypothesis by showing that glacial erosion works with remarkable efficiency in the tropics, precisely where it is likely to be least effective. Our work also draws attention to landscapes with ambiguous signs of glacial erosion, as there are apparent instances of heavily modified, pre-LGM buzzcut surfaces in several tropical ranges. These perched, possibly pre-LGM landscapes may offer a window into previous phases of buzzcutting, and place speed limits on the rate of post-glacial scarp encroachment.

Nivation landforms in the western Great Basin and their paleoclimatic significance

USGS Publications Warehouse

Dohrenwend, J.C.

1984-01-01

More than 10,000 nivation landforms occur in the higher mountain ranges of the western Great Basin. They range from small, subtle hollows with head scarps a few meters high and a few tens of meters long to broad, clearly defined terraces as much as 220 m wide bounded by bold, steeply sloping head scarps as much as 30 m high and 1600 m long. Distribution of these nivation hollows is strongly influenced by elevation, slope orientation, local relief, and substrate lithology. About 95% occur between 2200 and 3000 m elevation, and nearly 80% are situated on north-northwest-to east-northeast-facing slopes. They occur mainly in areas of moderately sloping terrain and moderate local relief, and they are preferentially developed on relatively incompetent substrates including terrigenous sedimentary deposits, volcanic and metavolcanic rocks of intermediate composition, and deeply weathered granitoid rocks. Nearly all of these nivation hollows are relict. They are most abundant near areas of late Pleistocene glaciation but rarely occur within such areas. Most are veneered with colluvium and are well vegetated, and many hollows in the Mono Basin area are veneered with volcanic ash at least 700 yr old. Distribution of nivation hollows suggests that (1) the full-glacial nivation threshold altitude (NTA) rose from north to south at 190 m per degree of latitude, subparallel to, and approximately 740 m lower than, the full-glacial equilibrium-line altitude (ELA) and about 1370 m lower than the estimated modern ELA; (2) the difference between the full-glacial and modern ELAs indicates an approximate 7??C full-glacial mean-annual-temperature depression throughout the Great Basin; and (3) the full-glacial mean annual temperature at the NTA is estimated to have been approximately 0?? to 1??C, assuming little change in accumulation-season precipitation. ?? 1984.

Intraductal delivery of adenoviruses targets pancreatic tumors in transgenic Ela-myc mice and orthotopic xenografts.

PubMed

José, Anabel; Sobrevals, Luciano; Miguel Camacho-Sánchez, Juan; Huch, Meritxell; Andreu, Núria; Ayuso, Eduard; Navarro, Pilar; Alemany, Ramon; Fillat, Cristina

2013-01-01

Gene-based anticancer therapies delivered by adenoviruses are limited by the poor viral distribution into the tumor. In the current work we have explored the feasibility of targeting pancreatic tumors through a loco-regional route. We have taken advantage of the ductal network in the pancreas to retrogradelly inject adenoviruses through the common bile duct in two different mouse models of pancreatic carcinogenesis: The transgenic Ela-myc mice that develop mixed neoplasms displaying both acinar-like and duct-like neoplastic cells affecting the whole pancreas; and mice bearing PANC-1 and BxPC-3 orthotopic xenografts that constitute a model of localized human neoplastic tumors. We studied tumor targeting and the anticancer effects of newly thymidine kinase-engineered adenoviruses both in vitro and in vivo, and conducted comparative studies between intraductal or intravenous administration. Our data indicate that the intraductal delivery of adenovirus efficiently targets pancreatic tumors in the two mouse models. The in vivo application of AduPARTKT plus ganciclovir (GCV) treatment induced tumor regression in Ela-myc mice. Moreover, the intraductal injection of ICOVIR15-TKT oncolytic adenoviruses significantly improved mean survival of mice bearing PANC-1 and BxPC-3 pancreatic xenografts from 30 to 52 days and from 20 to 68 days respectively (p less than 0.0001) when combined with GCV. Of notice, both AduPARTKT and ICOVIR15-TKT antitumoral responses were stronger by ductal viral application than intravenously, in line with the 38-fold increase in pancreas transduction observed upon ductal administration. In summary our data show that cytotoxic adenoviruses retrogradelly injected to the pancreas can be a feasible approach to treat localized pancreatic tumors.

What do We Know the Snow Darkening Effect Over Himalayan Glaciers?

NASA Technical Reports Server (NTRS)

Yasunari, T. J.; Lau, K.-U.; Koster, R. D.; Suarez, M.; Mahanama, S. P.; Gautam, R.; Kim, K. M.; Dasilva, A. M.; Colarco, P. R.

2011-01-01

The atmospheric absorbing aerosols such as dust, black carbon (BC), organic carbon (OC) are now well known warming factors in the atmosphere. However, when these aerosols deposit onto the snow surface, it causes darkening of snow and thereby absorbing more energy at the snow surface leading to the accelerated melting of snow. If this happens over Himalayan glacier surface, the glacier meltings are expected and may contribute the mass balance changes though the mass balance itself is more complicated issue. Glacier has mainly two parts: ablation and accumulation zones. Those are separated by the Equilibrium Line Altitude (ELA). Above and below ELA, snow accumulation and melting are dominant, respectively. The change of ELA will influence the glacier disappearance in future. In the Himalayan region, many glacier are debris covered glacier at the terminus (i.e., in the ablation zone). Debris is pieces of rock from local land and the debris covered parts are probably not affected by any deposition of the absorbing aerosols because the snow surface is already covered by debris (the debris covered parts have different mechanism of melting). Hence, the contribution of the snow darkening effect is considered to be most important "over non debris covered part" of the Himalayan glacier (i.e., over the snow or ice surface area). To discuss the whole glacier retreat, mass balance of each glacier is most important including the discussion on glacier flow, vertical compaction of glacier, melting amount, etc. The contribution of the snow darkening is mostly associated with "the snow/ice surface melting". Note that the surface melting itself is not always directly related to glacier retreats because sometimes melt water refreezes inside of the glacier. We should discuss glacier retreats in terms of not only the snow darkening but also other contributions to the mass balance.

42 CFR 447.502 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

...) approved by the Food and Drug Administration (FDA), including an authorized generic drug. It includes a... license approval (ELA) or antibiotic drug approval (ADA). Lagged price concession means any discount or... of natural origin, or independently by means of chemical synthesis, or by a combination of extraction...

42 CFR 447.502 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

...) approved by the Food and Drug Administration (FDA), including an authorized generic drug. It includes a... license approval (ELA) or antibiotic drug approval (ADA). Lagged price concession means any discount or... of natural origin, or independently by means of chemical synthesis, or by a combination of extraction...

42 CFR 447.502 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) approved by the Food and Drug Administration (FDA), including an authorized generic drug. It includes a... license approval (ELA) or antibiotic drug approval (ADA). Lagged price concession means any discount or... of natural origin, or independently by means of chemical synthesis, or by a combination of extraction...

42 CFR 447.502 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

...) approved by the Food and Drug Administration (FDA), including an authorized generic drug. It includes a... license approval (ELA) or antibiotic drug approval (ADA). Lagged price concession means any discount or... of natural origin, or independently by means of chemical synthesis, or by a combination of extraction...

CXBN-2 CubeSat – ELaNa XVII

NASA Image and Video Library

2016-12-08

The Cosmic X-Ray Background NanoSat-2 (CXBN-2) CubeSat Mission developed by Morehead State University and its partners the Keldysh Institute (Moscow, Russia), the Maysville Community and Technical College (Morehead, KY) and KYSpace LLC (Lexington, KY) will increase the precision of measurements of the Cosmic X-Ray Background in the 30-50 keV range to a precision of <5%, thereby constraining models that attempt to explain the relative contribution of proposed sources lending insight into the underlying physics of the early universe. The mission addresses a fundamental science question that is central to our understanding of the structure, origin, and evolution of the universe by potentially lending insight into both the high-energy background radiation and into the evolution of primordial galaxies. Launched by NASA’s CubeSat Launch Initiative NET April 18, 2017 ELaNa XVII mission on the seventh Orbital-ATK Cygnus Commercial Resupply Services (OA-7) to the International Space Station and deployed on tbd.

Remote Sensing based modelling of Annual Surface Mass Balances of Chhota Shigiri Glacier, Western Himalayas, India

NASA Astrophysics Data System (ADS)

Chandrasekharan, Anita; Ramsankaran, Raaj

2017-04-01

The current study aims at modelling glacier mass balances over Chhota Shigiri glacier (32.28o N; 77.58° E) in Himachal Pradesh, India using the Equilibrium Line Altitude (ELA) gradient approach proposed by Rabatel et al. (2005). The model requires yearly ELA, average mass balance and mass balance gradient to estimate annual mass balance of a glacier which can be obtained either through field measurements or remote sensing observations. However, in view of the general scenario of lack of field data for Himalayan glaciers, in this study the model has been applied only using the inputs derived through multi-temporal satellite remote sensing observations thus eliminating the need for any field measurements. Preliminary analysis show that the obtained results are comparable with the observed field mass balance. The results also demonstrate that this approach with remote sensing inputs has potential to be used for glacier mass balance estimations provided good quality multi-temporal remote sensing dataset are available.

Progress of p-channel bottom-gate poly-Si thin-film transistor by nickel silicide seed-induced lateral crystallization

NASA Astrophysics Data System (ADS)

Lee, Sol Kyu; Seok, Ki Hwan; Park, Jae Hyo; Kim, Hyung Yoon; Chae, Hee Jae; Jang, Gil Su; Lee, Yong Hee; Han, Ji Su; Joo, Seung Ki

2016-06-01

Excimer laser annealing (ELA) is known to be the most common crystallization technology for the fabrication of low-temperature polycrystalline-silicon (poly-Si) thin-film transistors (TFTs) in the mass production industry. This technology, however, cannot be applied to bottom-gate (BG) TFTs, which are well developed for the liquid-crystal display (LCD) back-planes, because strong laser energy of ELA can seriously damage the other layers. Here, we propose a novel high-performance BG poly-Si TFT using Ni silicide seed-induced lateral crystallization (SILC). The SILC technology renders it possible to ensure low damage in the layers, smooth surface, and longitudinal large grains in the channel. It was observed that the electrical properties exhibited a steep subthreshold slope of 110 mV/dec, high field-effect mobility of 304 cm2/Vsec, high I on/ I off ratio of 5.9 × 107, and a low threshold voltage of -3.9 V.

Late Pleistocene glacial fluctuations in Cordillera Oriental, subtropical Andes

NASA Astrophysics Data System (ADS)

Martini, Mateo A.; Kaplan, Michael R.; Strelin, Jorge A.; Astini, Ricardo A.; Schaefer, Joerg M.; Caffee, Marc W.; Schwartz, Roseanne

2017-09-01

The behavior of subtropical glaciers during Middle to Late Pleistocene global glacial maxima and abrupt climate change events, specifically in Earth's most arid low-latitude regions, remains an outstanding problem in paleoclimatology. The present-day climate of Cordillera Oriental, in arid northwestern Argentina, is influenced by shifts in subtropical climate systems, including the South American Summer Monsoon. To understand better past glacier-subtropical climates during the global Last Glacial Maximum (LGM, 26.5-19 ka) and other time periods, we combined geomorphic features with forty-two precise 10Be ages on moraine boulders and reconstructed paleo-equilibrium line altitudes (ELA) at Nevado de Chañi (24°S) in the arid subtropical Andes. We found a major glacial expansion at ∼23 ± 1.6 ka, that is, during the global LGM. Additional glacial expansions are observed before the global LGM (at ∼52-39 ka), and after, at 15 ± 0.5 and 12 ± 0.6 ka. The ∼15 ka glacial event was found on both sides of Chañi and the ∼12 ka event is only recorded on the east side. Reconstructed ELAs of the former glaciers exhibit a rise from east to west that resembles the present subtropical climate trajectory from the Atlantic side of the continent; hence, we infer that this climate pattern must have been present in the past. Based on comparison with other low-latitude paleoclimate records, such as those from lakes and caves, we infer that both temperature and precipitation influenced past glacial occurrence in this sector of the arid Andes. Our findings also imply that abrupt deglacial climate events associated with the North Atlantic, specifically curtailed meridional overturning circulation and regional cooling, may have had attendant impacts on low subtropical Southern Hemisphere latitudes, including the climate systems that affect glacial activity around Nevado de Chañi.

The response of glaciers to climate change

NASA Astrophysics Data System (ADS)

Klok, Elisabeth Jantina

2003-12-01

The research described in this thesis addresses two aspects of the response of glaciers to climate change. The first aspect deals with the physical processes that govern the interaction between glaciers and climate change and was treated by (1) studying the spatial and temporal variation of the glacier albedo from satellite images, (2) investigating the spatial distribution of the surface energy and mass balance of a glacier, and (3) investigating the sensitivity of the mass balance to climate change. All of these studies are focused on Morteratschgletscher in Switzerland. The second aspect is the climatic interpretation of glacier length fluctuations. This was studied by developing a model that calculates historical mass balance records from global glacier length fluctuations. To increase our understanding of the variations in glacier albedo, we derived surface albedos from 12 Landsat images. This constituted a stringent test for the retrieval methodology applied because Morteratschgletscher is very steep and rugged, which strongly influences the satellite signal. We aimed to retrieve surface albedos while taking into account all important processes that influence the relationship between the satellite signal and the surface albedo, e.g. the topographic effects on incoming solar radiation, and the anisotropic nature of the reflection pattern of ice and snow surfaces. We then analysed the spatial and temporal pattern of the surface albedo. We developed a two-dimensional mass balance model based on the surface energy balance to study the spatial distribution of the energy and mass balance fluxes of Morteratschgletscher. Meteorological data from weather stations in the vicinity of Morteratschgletscher serve as input for the model. We corrected incoming solar radiation for shading, aspect, slope, reflection from surrounding slopes, and obstruction of the sky. Ignoring these effects results in an increase in solar radiation of 37%, causing a decrease in the mass balance of 0.34 m w.e. We modelled the mass balance for 1999 and 2000 and analysed the spatial distribution. We then ran the model for a period of 23 years and calculated the mass balance sensitivity to climate change by perturbing air temperature and precipitation. The mass balance sensitivity to temperature and precipitation are ˜0.59 m w.e. a-1 K-1 and 0.17 m w.e. a-1 per 10 percent respectively. We also used three other albedo parameterisations to calculate the mass balance sensitivity since albedo parameterisations are often regarded as a main source of error in mass balance models. We concluded that an accurate estimate of the mass balance sensitivity requires a parameterisation that captures the process of a decreasing snow albedo when a snow pack gets older or thinner. To extract a climate signal from worldwide glacier length fluctuations, we developed a simple model. The climate signal is represented as a reconstruction of the mass balance and the equilibrium line altitude (ELA). The model was tested on seventeen European glacier length records and then applied to nineteen glacier length records from different parts of the world. Between 1910 and 1959, the average increase in the reconstructed ELAs is 33 m. This implies that during the first half of the twentieth century, the climate was warmer or drier than before. The reconstructed ELAs decrease to lower elevations after 1960 and up till 1980, when most of the reconstructions end. The results can be translated into a global temperature increase of about 0.8 K for the period 1910-1959

75 FR 24934 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-06

... student archived data (e.g., state mandated standardized test scores); follow-up surveys for students... experimental design that utilizes the random assignment. LIC is an English Language Arts (ELA)-based character education curriculum that is expected to have positive impacts on student academic performance, attendance...

Sensitivity of annual mass balance gradient and Hypsometry to the changing climate: the case of Dokriani Glacier, central Himalaya, India

NASA Astrophysics Data System (ADS)

Pratap, B.

2015-12-01

The glacier mass balance is undelayed, unfiltered and direct method to assess the impact of climate change on the glaciers. Many studies suggest that some of the Himalayan glaciers have lost their mass at an increased rate during the past few decades. Furthermore, the mass balance gradient and hypsometric analysis are important to understand the glacier response towards climatic perturbations. Our long term in-situ monitoring on the Dokriani Glacier provides great insights to understand the variability in central Himalayan glaciers. We report the relationship between glacier hypsometry and annual mass balance gradient (12 years) to understand the glacier's response towards climate change. Dokriani Glacier in the Bhagirathi basin is a small (7 km2) NNW exposed glacier in the western part of central Himalaya, India. The study analysed the annual balance, mass balance gradient and length changes observed during first decade of 21st century (2007-2013) and compare with the previous observations of 1990s (1992-2000). A large spatial variability in the mass balance gradients of two different periods has been observed. The equilibrium-line altitude (ELA) was fluctuated between 5000 and 5100 m a.s.l. and the derived time averaged ELA (ELAn) and balance budget ELA (ELA0) were 5075 and 4965 m a.s.l respectively during 1992-2013. The observed time-averaged accumulation-area ratio (AARn) and balance budget AAR (AAR0) were 0.67 and 0.72 respectively during 1992-2013. The higher value of AAR comprises due to flat and broader accumulation area (4.50 km2) of the glacier. Although, having larger accumulation area, the glacier has faced strong mass wasting with average annual ablation of -1.82 m w.e. a-1 in the ablation zone as compare to residual average annual accumulation of 0.41 m w.e. a-1. Based on the annual mass balance series (12 years) Dokriani Glacier has continuous negative annual balances with monotonically negative cumulative mass loss of -3.86 m w.e with the average loss of -0.32 m w.e a-1. Dokriani Glacier also showed continues recession from 1992 to present. Snout was ascended 95 m a.s.l. from an elevation of 3870 m a.s.l. in 1992 to an elevation of 3965 m a.s.l. in 2013. The progressive retreat of the glacier affects its extension and volume and covered by continuous enhancement of debris in the lower ablation zone.

Elaidate-Intercalated hydrotalcite as a sorbent material for metalaxyl immobilitzation in soil

NASA Astrophysics Data System (ADS)

López-Cabeza, Rocío; Cornejo, Juan; Hermosín, María C.; Cox, Lucía; Celis, Rafael

2015-04-01

Layered double hydroxides (LDHs), also known as hydrotalcite-like compounds (HTs), comprise a special group of layered materials. Their structure consists of positively charged layers of mixed divalent (MII) and trivalent (MIII) metal hydroxide [MII1-xMIIIx(OH)2]x+, with the positive charge being balanced by inorganic hydrated anions (An-x/n·mH2O), which occupy the interlayer space. LDHs have anion exchange properties and, therefore, are good sorbents for anionic pollutants. In addition, the anionic exchange properties of LDHs allow the intercalation of organic anions in the interlayer space to render the LDH surface hydrophobic. This increases its affinity to hydrophobic organic compounds. Pesticides with chiral centers are an emerging class of organic pollutants and it has become clear that addressing the different efficacy, toxicity, and environmental behavior of chiral pesticide enantiomers is necessary to avoid the incorrect assumption that enantiomers have identical environmental behavior. Appropriate soil remediation strategies accounting for the enantioselective behavior of chiral pesticide enantiomers are also needed. In this work, we evaluated the performance of elaidate-modified hydrotalcite (HT-ELA) as a sorbent to remove the chiral fungicide metalaxyl from aqueous solution and as an amendment for metalaxyl immobilization in soil. Analysis of metalaxyl by chiral high-performance liquid chromatography allowed us to monitor the sorption and mobility of the two enantiomers of metalaxyl, S-(+)-metalaxyl and R-(-)-metalaxyl, independently. Batch sorption experiments showed that HT-ELA [Mg3Al(OH)8ELA] displayed an excellent performance as an sorbent of the two enantiomers of metalaxyl from aqueous solution and that its addition to a sandy loam agricultural soil at a rate of 1% greatly enhanced the sorption of metalaxyl enantiomers by the soil. Column leaching experiments demonstrated that amending the soil top layer (0-2.5 cm) with HT-ELA at a rate of 1% reduced the leaching of S- and R-metalaxyl. The R-enantiomer of metalaxyl leached less than the S-enantiomer due to its faster degradation in the soil. Our results illustrate the ability of elaidate-modified hydrotalcite to enhance the retention of the two enantiomers of the fungicide metalaxyl in the tested soil, which may be useful in the design of immobilization strategies, particularly of the more persistent S-metalaxyl enantiomer, which may represent increased risk of ground water contamination. Acknowledgments: MINECO Project AGL2011-23779, FACCE-JPI Project Designchar4food, JA Research Group AGR-264 and FEDER-FSE (OP 2007-2013).

Glacial chronology and palaeoclimate in the Bystra catchment, Western Tatra Mountains (Poland) during the Late Pleistocene

NASA Astrophysics Data System (ADS)

Makos, Michał; Rinterknecht, Vincent; Braucher, Régis; Żarnowski, Michał

2016-02-01

Deglaciation chronology of the Bystra catchment (Western Tatra Mountains) has been reconstructed based on 10Be exposure age dating. Fourteen rock samples were collected from boulders located on three moraines that limit the horizontal extent of the LGM maximum advance and the Lateglacial recessional stage. The oldest preserved, maximum moraine was dated at 15.5 ± 0.8 ka, an age that could be explained more likely by post-depositional erosion of the moraine. Such scenario is supported by geomorphologic and palaeoclimatological evidence. The younger cold stage is represented by well-preserved termino-lateral moraine systems in the Kondratowa and Sucha Kasprowa valleys. The distribution of the moraine ridges in both valleys suggest a complex history of deglaciation of the area. The first Late-glacial re-advance (LG1) was followed by a cold oscillation (LG2), that occurred at around 14.0 ± 0.7-13.7 ± 1.2 ka. Glaciers during both stages had nearly the same horizontal extent, however, their thickness and geometry changed significantly, mainly due to local climatic conditions triggered by topography, controlling the exposition to solar radiation. The LG1 stage occurred probably during the pre-Bølling cold stage (Greenland Stadial 2.1a), however, the LG2 stage can be correlated with the cooling at around 14 ka during the Greenland Interstadial 1 (GI-1d - Older Dryas). This is the first chronological evidence of the Older Dryas in the Tatra Mountains. The ELA of the maximum Bystra glacier was located at 1480 m a.s.l. in accordance with the ELA in the High Tatra Mountains during the LGM. During the LG1 and LG2 stages, the ELA in the catchment rose up to 1520-1530 m a.s.l. and was located approximately 100-150 m lower than in the eastern part of the massif. Climate modelling results show that the Bystra glacier (maximum advance) could have advanced in the catchment when mean annual temperature was lower than today by 11-12 °C and precipitation was reduced by 40-60%. This is in accordance with LGM conditions previously reported for the High Tatras. During the LG1 and LG2 stages the temperature decrease in the study area reached 10 °C and precipitation was lower by ∼30% compare to modern conditions. This resulted in slightly higher accumulation (20-30%) in the Western Tatra Mountains compare to the High Tatra Mountains.

A Professional Learning Community Approach to Improving English/Language Arts Instructional Planning

ERIC Educational Resources Information Center

Kotsko, Adrienne

2017-01-01

Simply defined, effective English Language Arts (ELA) instruction is cohesive, integrated, and requires students to think deeply. Creating such instruction is difficult, however, because of insufficient training in instructional planning and the numerous types of curricula teachers must navigate that may not align well. Therefore, new secondary…

What's Hot: Texas and the Nation

ERIC Educational Resources Information Center

Cassidy, Jack; Ortlieb, Evan; Grote-Garcia, Stephanie

2016-01-01

For two decades the International Literacy Association (ILA) has published the "What's Hot, What's Not in Literacy Survey." In the last five years, the hottest topics featured on the lists have largely been connected to the English Language Arts Common Core State Standards (ELA CCSS)--a publication produced by the National Governors…

The Reciprocal Relationship between Text Literacy and Music Literacy among Beginning Band Students

ERIC Educational Resources Information Center

Carroll, David Lawson

2017-01-01

This dissertation examines the reciprocal relationship between text literacy and music literacy through an experimental design. Music teachers and English Language Arts (ELA) teachers often address similar components of literacy, including fluency, comprehension, and symbolic interpretation. The theory of cognitive structuralism maintains that…

Collaborative Strategic Reading: Findings from Experienced Implementers

ERIC Educational Resources Information Center

Vaughn, Sharon; Roberts, Greg; Klingner, Janette K.; Swanson, Elizabeth A.; Boardman, Alison; Stillman-Spisak, Stephanie J.; Mohammed, Sarojani S.; Leroux, Audrey J.

2013-01-01

This study examined the effects and fidelity of collaborative strategic reading (CSR) implemented by experienced CSR teachers (participated in previous study; Vaughn et al., 2011) on the reading comprehension outcomes of students in English/Language Arts (ELA) or Reading classes. Eligible teachers (12 of 17; others reassigned to teach…

Factors Affecting Minority Students' College Readiness in Mathematics

ERIC Educational Resources Information Center

Houser, Latisha Cheree-Square; An, Shuhua

2015-01-01

This study examined how gender; race/ethnicity; language; socioeconomic status; California Standards Test (CST) scores in mathematics, science, and ELA; and California High School Exit Exam mathematics predict college-ready results on the Early Assessment Program (EAP) in mathematics in urban areas of southern California. Approximately 1,700 high…

Teaching for the Fun of It

ERIC Educational Resources Information Center

Mitcham, Karen

2009-01-01

The purpose of having fun in the English language arts (ELA) classroom is twofold: (1) build community; and (2) alleviate the monotony, drudgery, and anxiety that reading, speaking, and writing often produce, especially in struggling students and any and all who are future members of Garrison Keillor's Lake Woebegone Professional Organization of…

Rhetorical Reading as a Gateway to Disciplinary Literacy

ERIC Educational Resources Information Center

Warren, James E.

2013-01-01

The Common Core State Standards (CCSS) require literacy instruction for secondary students across content areas, but they also recommend that this instruction account for the discipline-specific nature of academic texts. Since English language arts (ELA) teachers and literacy specialists are also responsible for teaching students to read across…

Literacy Instruction in the Wake of Common Core State Standards

ERIC Educational Resources Information Center

Barrett-Mynes, Jennifer

2013-01-01

As teachers modify their instruction to meet English Language Arts (ELA) Common Core State Standards (CCSS), how do these modifications influence literacy instruction and learning opportunities afforded to students? While the CCSS standardized objectives for literacy instruction, the enacted curriculum is uniquely shaped by teachers and their…

Teaching for Social Justice: From Conceptual Frameworks to Classroom Practices

ERIC Educational Resources Information Center

Dover, Alison G.

2013-01-01

In this article, the author presents the results of a multistate study examining how teachers, and specifically secondary English Language Arts (ELA) teachers, conceptualize and implement teaching for social justice in standards-based contexts. Additional analysis underscores how this practice both reflects and extends earlier equity-oriented…

Elementary ELA/Social Studies Integration: Challenges and Limitations

ERIC Educational Resources Information Center

Heafner, Tina L.

2018-01-01

Adding instructional time and holding teachers accountable for teaching social studies are touted as practical, logical steps toward reforming the age-old tradition of marginalization. This qualitative case study of an urban elementary school, examines how nine teachers and one administrator enacted district reforms that added 45 minutes to the…

MOLECULAR, PROTEIN AND HISTOLOGICAL INDICATORS IN FATHEAD MINNOWS EXPOSEDF TO EE2 IN A WHOLE-LAKE DOSING EXPERIMENT

EPA Science Inventory

A whole-lake endocrine disruption experiment was conducted by Fisheries and Oceans Canada at the Experimental Lakes Area (ELA), northwestern Ontario from 2001 to 2003. This experiment examined population, organism, biochemical and cellular-level effects in lake trout, white suck...

VITELLOGENIN GENE EXPRESSION IN FATHEAD MINNOWS EXPOSED TO EE2 IN A WHOLE LAKE DOSING EXPERIMENT

EPA Science Inventory

A whole-lake endocrine disruption experiment was conducted by Fisheries and Oceans Canada at the Experimental Lakes Area (ELA), northwestern Ontario in 2001 and 2002. This experiment examined population, organism, biochemical and cellular-level effects in lake trout, white sucke...

Material Properties of Three Candidate Elastomers for Space Seals Applications

NASA Technical Reports Server (NTRS)

Bastrzyk, Marta B.; Daniels, Christopher C.; Oswald, Jay J.; Dunlap, Patrick H., Jr.; Steinetz, Bruce M.

2010-01-01

A next-generation docking system is being developed by the National Aeronautics and Space Administration (NASA) to support Constellation Space Exploration Missions to low Earth orbit (LEO), to the Moon, and to Mars. A number of investigations were carried out to quantify the properties of candidate elastomer materials for use in the main interface seal of the Low Impact Docking System (LIDS). This seal forms the gas pressure seal between two mating spacecraft. Three candidate silicone elastomer compounds were examined: Esterline ELA-SA-401, Parker Hannifin S0383-70, and Parker Hannifin S0899-50. All three materials were characterized as low-outgassing compounds, per ASTM E595, so as to minimize the contamination of optical and solar array systems. Important seal properties such as outgas levels, durometer, tensile strength, elongation to failure, glass transition temperature, permeability, compression set, Yeoh strain energy coefficients, coefficients of friction, coefficients of thermal expansion, thermal conductivity and diffusivity were measured and are reported herein.

REPORTING OF SELECTED EPA-SPONSORED FORM EIA-767 DATA FOR 1985-1987

EPA Science Inventory

The report is a compilation of 1985-87 data based on the Energy Information Administration's (ElA's) Form 767, "Steam-Electric Plant Operation and Design Report," an annual data collection form whose major output to date has been an annual data tape which is released to the publi...

Linking the North Carolina EOG Assessments to NWEA MAP Tests

ERIC Educational Resources Information Center

Northwest Evaluation Association, 2016

2016-01-01

Northwest Evaluation Association™ (NWEA™) is committed to providing partners with useful tools to help make inferences from the Measures of Academic Progress® (MAP®) interim assessment scores. Recently, NWEA completed a concordance study to connect the scales of the North Carolina End-of-Grade (EOG) English language arts (ELA) and math with those…

Supporting the Argumentative Writing of Students in Linguistically Diverse Classrooms: An Action Research Study

ERIC Educational Resources Information Center

Campbell, Yvonne C.; Filimon, Claudia

2018-01-01

The number of English language learners (ELLs) mainstreamed into regular classrooms continues to increase. Curricular writing standards required by the Common Core State Standards require students to write essays analytically in response to text(s). Many English Language Arts (ELA) teachers may worry about effectively delivering essay writing…

The Influence of Race-Ethnicity and Physical Activity Levels on Elementary School Achievement

ERIC Educational Resources Information Center

Caldas, Stephen J.; Reilly, Monique S.

2018-01-01

The authors used structural equation modeling to map the relationships between student race-ethnicity via the mediating variable physical activity on English language arts (ELA) and mathematics achievement among 964 fourth- and fifth-grade students. The students attended a New York City Metropolitan area school district and completed the Physical…

Composing with New Technology: Teacher Reflections on Learning Digital Video

ERIC Educational Resources Information Center

Bruce, David L.; Chiu, Ming Ming

2015-01-01

This study explores teachers' reflections on their learning to compose with new technologies in the context of teacher education and/or teacher professional development. English language arts (ELA) teachers (n = 240) in 15 courses learned to use digital video (DV), completed at least one DV group project, and responded to open-ended survey…

The Fog of Peace: Planning and Executing The Restoration of Panama

DTIC Science & Technology

1992-04-15

posean armas Ilegalus., CONSTITUCION Y LAS LEVES DE lO0limpleard Ia fuerza sdlo cuando sea necesarlo y cl mifnmtoPANAMA, ~~~ti ENDFNS ELA( ucrz.a...rcqucrldw, hacienda uso tic lit ftierm. mortal PANAM , ENDEFESA D LA nlcarriente coini ultima rcuurso. DEMOCRACIA Oath Commandments 99 APPENDIX G U.S

Integrating Computational Thinking into Technology and Engineering Education

ERIC Educational Resources Information Center

Hacker, Michael

2018-01-01

Computational Thinking (CT) is being promoted as "a fundamental skill used by everyone in the world by the middle of the 21st Century" (Wing, 2006). CT has been effectively integrated into history, ELA, mathematics, art, and science courses (Settle, et al., 2012). However, there has been no analogous effort to integrate CT into…

Reading Preparation of Secondary ELA Teachers: A U.S. Survey of State Licensure Requirements

ERIC Educational Resources Information Center

Lovette, Gail E.

2013-01-01

Secondary teacher preparation in reading in the U.S. has received minimal attention from the research community despite the almost universal implementation of the Common Core State Standards. In response, numerous publications have demanded that secondary teachers be fully prepared to support the needs of struggling readers, especially ELA…

Impact Evaluation of National Writing Project Professional Development Program

ERIC Educational Resources Information Center

Gallagher, H. Alix; Woodworth, Katrina; McCaffrey, Teresa; Park, Christina J.; Wang, Haiwen

2014-01-01

Improving teacher effectiveness is a key strategy to ensure student readiness for college and careers and to address achievement gaps and persistent low performance. In response to the new Common Core State Standards for English Language Arts (CCSS-ELA) the National Writing Project (NWP) created a professional development (PD) program to support…

Tableau's Influence on the Oral Language Skills of Students with Language-Based Learning Disabilities

ERIC Educational Resources Information Center

Anderson, Alida; Berry, Katherine A.

2017-01-01

This study examined the influence of tableau on the expressive language skills of three students with language-based learning disabilities in inclusive urban fourth-grade English language arts (ELA) classroom settings. Data were collected on linguistic productivity, specificity, and narrative cohesion through analysis of students' responses to…

Common Core, Commonplaces, and Community in Teaching Reading

ERIC Educational Resources Information Center

Roskos, Kathleen; Neuman, Susan B.

2013-01-01

Joseph Schwab, a curriculum theorist, described four commonplaces, or universals, of teaching: content, students, milieu and teachers. This article considers how the Reading Standards of the ELA-CCSS are shaping these commonplaces in the teaching of reading. The organization of the Reading Standards, for example, focuses on two broad grade bands,…

Cloud-Based Collaborative Writing and the Common Core Standards

ERIC Educational Resources Information Center

Yim, Soobin; Warschauer, Mark; Zheng, Binbin; Lawrence, Joshua F.

2014-01-01

The Common Core State Standards emphasize the integration of technology skills into English Language Arts (ELA) instruction, recognizing the demand for technology-based literacy skills to be college- and career- ready. This study aims to examine how collaborative cloud-based writing is used in in a Colorado school district, where one-to-one…

California Education: Planning for a Better Future

ERIC Educational Resources Information Center

Larsen, Eric; Weston, Margaret

2011-01-01

Proficiency rates among California students continue to rise. At the end of the 2009-10 school year, the share of students who demonstrated proficiency on the California Standards Test was greater than 50 percent in both English language arts (ELA) and math. California's proficiency rates have increased more than 18 percentage points over the last…

Program Development to Study Faired Towlines.

DTIC Science & Technology

1980-02-01

34Automobiles under Crash Loading", lIT Research Institute, October 1977. [19] Antman , S. S., "Ordinary Differential Equations of Non-Linear Elas...1976. [20] Green, A. E. and N. Laws, "A General Theory of Rods", Proceedings of the Royal Society (London) A293, pp. 145-155, 1966. [21] Antman , S. S

What Can Students Do with the Words They Know? An ELA Teacher Takes on Science

ERIC Educational Resources Information Center

Hayden, H. Emily; Eades-Baird, Michelle

2016-01-01

The Common Core State Standard and Next Generation Science Standards emphasize language and literacy across disciplines, requiring shifts in teaching practices and inventive approaches. This case study focuses on the instructional decision-making and activities of one uniquely experienced and qualified seventh-grade science teacher, whose English…

Technology and Engineering Education and the Common Core Standards

ERIC Educational Resources Information Center

Rust, Terrie

2012-01-01

The nearly unanimous state acceptance of the Common Core State Standards (CCSS) in mathematics and English Language Arts (ELA) jolted many teachers out of their complacency. How was this major change going to impact their teaching and their curriculum? What changes would be made in student assessments and teacher accountability? The good news is…

Supporting Kindergartners' Science Talk in the Context of an Integrated Science and Disciplinary Literacy Curriculum

ERIC Educational Resources Information Center

Wright, Tanya S.; Gotwals, Amelia Wenk

2017-01-01

Given the growing evidence of limited attention to science, disciplinary literacy, and oral language in elementary classrooms serving low-income children, this study focused on designing and testing an integrated science and disciplinary language and literacy curriculum aligned with NGSS and CCSS ELA standards for kindergarten. We used…

Learners without Borders: Connected Learning in a Digital Third Space

ERIC Educational Resources Information Center

Moran, Clarice M.

2018-01-01

Authentic field experiences are an important aspect of most teacher education programs, yet collaboration often is difficult because of distance and limited resources. This collective case study aimed to explore the experiences of 30 ninth-grade English language arts (ELA) students and 17 preservice English education teachers as they collaborated…

Preservice Teachers' Understanding of the Language Arts: Using a Lens of Critical Literacy

ERIC Educational Resources Information Center

Bender-Slack, Delane; Young, Teresa

2016-01-01

Preservice teachers are placed in educational environments to learn about teaching literacy and about literacy's role in the English Language Arts (ELA) classroom. Of particular significance is how preservice teachers perceive and understand the varied components of language arts (i.e., reading, writing, speaking, listening, viewing, and visually…

Insight into glacier climate interaction: reconstruction of the mass balance field using ice extent data

NASA Astrophysics Data System (ADS)

Visnjevic, Vjeran; Herman, Frédéric; Licul, Aleksandar

2016-04-01

With the end of the Last Glacial Maximum (LGM), about 20 000 years ago, ended the most recent long-lasting cold phase in Earth's history. We recently developed a model that describes large-scale erosion and its response to climate and dynamical changes with the application to the Alps for the LGM period. Here we will present an inverse approach we have recently developed to infer the LGM mass balance from known ice extent data, focusing on a glacier or ice cap. The ice flow model is developed using the shallow ice approximation and the developed codes are accelerated using GPUs capabilities. The mass balance field is the constrained variable defined by the balance rate β and the equilibrium line altitude (ELA), where c is the cutoff value: b = max(βṡ(S(z) - ELA), c) We show that such a mass balance can be constrained from the observed past ice extent and ice thickness. We are also investigating several different geostatistical methods to constrain spatially variable mass balance, and derive uncertainties on each of the mass balance parameters.

Improving the social and emotional climate of classrooms: a clustered randomized controlled trial testing the RULER Approach.

PubMed

Rivers, Susan E; Brackett, Marc A; Reyes, Maria R; Elbertson, Nicole A; Salovey, Peter

2013-02-01

The RULER Approach ("RULER") is a setting-level, social and emotional learning program that is grounded in theory and evidence. RULER is designed to modify the quality of classroom social interactions so that the climate becomes more supportive, empowering, and engaging. This is accomplished by integrating skill-building lessons and tools so that teachers and students develop their emotional literacy. In a clustered randomized control trial, we tested the hypothesis that RULER improves the social and emotional climate of classrooms. Depending upon condition assignment, 62 schools either integrated RULER into fifth- and sixth-grade English language arts (ELA) classrooms or served as comparison schools, using their standard ELA curriculum only. Multi-level modeling analyses showed that compared to classrooms in comparison schools, classrooms in RULER schools were rated as having higher degrees of warmth and connectedness between teachers and students, more autonomy and leadership among students, and teachers who focused more on students' interests and motivations. These findings suggest that RULER enhances classrooms in ways that can promote positive youth development.

Enhanced Performance of GaN-Based Green Light-Emitting Diodes with Gallium-Doped ZnO Transparent Conducting Oxide

NASA Astrophysics Data System (ADS)

Oh, Min-Suk; Seo, Inseok

2014-04-01

Ga-doped ZnO (GZO) transparent conducting oxide was grown by oxygen plasma-enhanced pulsed laser deposition. GZO grown in the presence of oxygen radicals had resistivity of 1 × 10-3 Ω cm and average visible (500-700 nm) transmittance of 92.5%. A low specific contact resistance of 6.5 × 10-4 Ω cm2 of GZO on p-GaN was achieved by excimer laser annealing (ELA) treatment of p-GaN before GZO electrode deposition. The ELA-treated light emitting diode (LED) fabricated with the GZO electrode as a current-spreading layer resulted in light-output power enhanced by 56.2% at 100 mA compared with that fabricated with a conventional Ni/Au metal electrode. The high-light output and low degradation of light-output power were attributed to the decrease in contact resistance between the p-GaN layer and the GZO electrode and uniform current spreading over the p-GaN layer. In addition, low contact resistance results in a decrease of self-heat generation during current drive.

Timing and paleoclimatic significance of Holocene glacier fluctuations in the Cordillera Vilcabamba of southern Peru

NASA Astrophysics Data System (ADS)

Licciardi, J. M.; Taggart, J. R.; Schaefer, J. M.; Lund, D. C.

2009-12-01

Past fluctuations in climatically sensitive tropical glaciers provide important insight into regional paleoclimatic trends and forcings, but well-dated chronologies are scarce, particularly during the Holocene. We have established precise cosmogenic 10Be surface exposure ages of moraine sequences in the Cordillera Vilcabamba (13°20’S latitude), located in the outer tropics of southern Peru. Results indicate the dominance of two major glacial culminations and associated climatic shifts in the Vilcabamba, including an early Holocene glacial interval and a somewhat less extensive glaciation late in the ‘Little Ice Age’ (LIA) period. Lichenometric measurements on the youngest moraines support the 10Be ages, but uncertainties in the lichen ages arise from the lack of a local lichen growth curve. The Peruvian glacier chronologies differ from a recently-developed New Zealand record but are broadly correlative with well-dated glacial records in Europe, suggesting climate linkages between the tropics and the North Atlantic region. For the latest Holocene, our leading hypothesis is that climate forcings involving southward migration of the Atlantic Intertropical Convergence Zone can explain concurrent glaciations in tropical South America and northern high latitudes, but the influence of other climate drivers such as the El Niño/Southern Oscillation may have also played a role. Estimated differences between equilibrium-line altitudes (ELAs) on modern glaciers and those inferred for expanded latest Holocene glaciers reveal an ELA rise of 165-200 m since the LIA, suggesting that temperatures 1.1-1.3°C cooler than present could have sustained glaciers at their LIA maximum positions if temperature was the only control, and thus providing an upper bound on temperature depression during the LIA. However, further work is required to constrain the likely role of precipitation changes. These new Peruvian glacier chronologies and ELA reconstructions complement ice core and lacustrine paleoclimate records in the vicinity, thereby increasing spatial and temporal coverage for identifying patterns of climate change in the tropical Andes during the Holocene.

10Be exposure age chronology of the last glaciation of the Roháčská Valley in the Western Tatra Mountains, central Europe

NASA Astrophysics Data System (ADS)

Engel, Zbyněk; Mentlík, Pavel; Braucher, Régis; Křížek, Marek; Pluháčková, Markéta; Arnold, Maurice; Aumaître, Georges; Bourlès, Didier; Keddadouche, Karim; Aster Team; Arnold, Maurice; Aumaître, Georges; Bourlès, Didier; Keddadouche, Karim

2017-09-01

10Be exposure ages from moraines and bedrock sites in the Roháčská Valley provide chronology of the last glaciation in the largest valley of the Western Tatra Mts., the Western Carpathians. The minimum apparent exposure age of 19.4 ± 2.1 ka obtained for the oldest sampled boulder and the mean age of 18.0 ± 0.8 ka calculated for the terminal moraine indicate that the oldest preserved moraine was probably deposited at the time of the global Last Glacial Maximum (LGM). The age of this moraine coincides with the termination of the maximum glacier expansion in other central European ranges, including the adjacent High Tatra Mts. and the Alps. The equilibrium line altitude (ELA) of the LGM glacier in the Roháčská Valley, estimated at 1400-1410 m a.s.l., was 50-80 m lower than in the eastern part of the range, indicating a positive ELA gradient from west to east among the north-facing glaciers in the Tatra Mts. Lateglacial glacier expansion occurred no later than 13.4 ± 0.5 ka and 11.9 ± 0.5 ka, as indicated by the mean exposure ages calculated for re-advance moraines. This timing is consistent with the exposure age chronology of the last Lateglacial re-advance in the High Tatra Mts., Alps and lower mountain ranges in central Europe. The ELA in the Roháčská Valley estimated at 1690-1770 m a.s.l. in this period was located 130-300 m lower than in the north-facing valleys in the High Tatra Mts. 10Be exposure ages obtained for a rock glacier constrains the timing of this landform stabilization in the Salatínska Valley and provides the first chronological evidence for the Lateglacial activity of rock glaciers in the Carpathians.

Linking glacial erosion and low-relief landscapes in tropical orogens

NASA Astrophysics Data System (ADS)

Cunningham, M.; Stark, C. P.; Kaplan, M. R.; Schaefer, J. M.; Galewsky, J.; Yoo, J.

2015-12-01

One significant way that climate influences orogenic evolution is by modulating glacial erosion. At mid-latitudes it is hypothesized that this climate-tectonic interplay is so strong that a "glacial buzzsaw" acting throughout the Quaternary outpaced tectonic uplift in most mountain belts and concentrated topography in a zone defined by the bounds of ELA fluctuation. Less attention has been paid to how the buzzsaw might manifest itself at low latitudes, where many mountain belts are just high enough to have been glaciated at the LGM but today sit well below the ELA. We have focused on the glacial history of Costa Rica and Taiwan, where we find evidence of ice cap erosion coincident with low-relief landscapes near the LGM ELA. Previous attempts to understand the formation of these perched, low-relief landscapes has mostly concerned interactions between fluvial erosion and geodynamics. Our work aims instead to describe the role that glacial erosion played in the evolution of these landscapes, and how they fit in the buzzsaw paradigm. At Cerro Chirripó in Costa Rica we use 10-Be surface exposure age dating of moraine boulders and scoured bedrock, field mapping, and remote sensing to constrain the timing, areal extent, and pattern of glacial erosion. We made similar observations of ice extent at Nanhudashan in Taiwan, where surface exposure age dating has previously been applied to glacial landforms (e.g. Hebenstreit et al., 2011; Siame et al., 2007). In Costa Rica, our 10-Be dates from scoured bedrock near the highest peak and terminal/lateral moraines show signs of ice-cap erosion until 22 ka. Similar arguments for LGM ice cap erosion have been made for Nanhudashan. Regional climate simulations (WRF) further constrain the timing and spatial extent of glaciation in these places, and the combination of field data and climate modeling will inform estimates of the magnitude of glacial erosion on perched landscapes.

Climatic vs. tectonic control on glacial relief

NASA Astrophysics Data System (ADS)

Prasicek, Günther; Herman, Frederic; Robl, Jörg

2017-04-01

The limiting effect of a climatically-induced glacial buzz-saw on the height of mountain ranges has been extensively discussed in the geosciences. The buzz-saw concept assumes that solely climate controls the amount of topography present above the equilibrium line altitude (ELA), while the rock uplift rate plays no relevant role. This view is supported by analyses of hypsometric patterns in orogens worldwide. Furthermore, numerical landscape evolution models show that glacial erosion modifies the hypsometry and reduces the overall relief of mountain landscapes. However, such models often do not incorporate tectonic uplift and can only simulate glacial erosion over a limited amount of time, typically one or several glacial cycles. Constraints on glacial end-member landscapes from analytical, time-independent models are widely lacking. Here we present a steady-state solution for a glacier equilibrium profile in an active orogen modified from the mathematical conception presented by Headley et al. (2012). Our approach combines a glacial erosion law with the shallow ice approximation, specifically the formulations of ice sliding and deformation velocities and ice flux, to calculate ice surface and bed topography from prescribed specific mass balance and rock uplift rate. This solution allows the application of both linear and non-linear erosion laws and can be iteratively fitted to a predefined gradient of specific mass balance with elevation. We tested the influence of climate (fixed rock uplift rate, different ELAs) and tectonic forcing (fixed ELA, different rock uplift rates) on steady-state relief. Our results show that, similar to fluvial orogens, both climate and rock uplift rate exert a strong influence on glacial relief and that the relation among rock uplift rate and relief is governed by the glacial erosion law. This finding can provide an explanation for the presence of high relief in high latitudes. Headley, R.M., Roe, G., Hallet, B., 2012. Glacier longitudinal profiles in regions of active uplift. Earth and Planetary Science Letters, 317-318, 354-362.

Three-dimensional perspective software for representation of digital imagery data. [Olympic National Park, Washington

NASA Technical Reports Server (NTRS)

Junkin, B. G.

1980-01-01

A generalized three dimensional perspective software capability was developed within the framework of a low cost computer oriented geographically based information system using the Earth Resources Laboratory Applications Software (ELAS) operating subsystem. This perspective software capability, developed primarily to support data display requirements at the NASA/NSTL Earth Resources Laboratory, provides a means of displaying three dimensional feature space object data in two dimensional picture plane coordinates and makes it possible to overlay different types of information on perspective drawings to better understand the relationship of physical features. An example topographic data base is constructed and is used as the basic input to the plotting module. Examples are shown which illustrate oblique viewing angles that convey spatial concepts and relationships represented by the topographic data planes.

Using Superheroes to Visually and Critically Analyze Comics, Stereotypes, and Society

ERIC Educational Resources Information Center

Cook, Mike P.; Frey, Ryle

2017-01-01

The purpose of this article is to provide teachers and students useful methods for utilizing the power of comic books as literacy sponsors in ELA classrooms. Given the continued boom in the popularity of comics in popular culture, this provides a relevant way to introduce students to visual and critical analysis. Engaging in meaningful analysis of…

Departmentalized or Self-Contained: The Relationship between Classroom Configuration and Student Achievement

ERIC Educational Resources Information Center

Mitchell, Viola T.

2013-01-01

The purpose of this quantitative study was to determine if classroom configuration--departmentalized and self-contained--is related to the academic achievement of Grade 6 students in a large urban school district as measured by California Standards Test (CST) scores in mathematics and English Language Arts (ELA) when controlling for prior academic…

Elevating Learner Achievement Using Formative Electronic Lab Assessments in the Engineering Laboratory: A Viable Alternative to Weekly Lab Reports

ERIC Educational Resources Information Center

Chen, Baiyun; DeMara, Ronald F.; Salehi, Soheil; Hartshorne, Richard

2018-01-01

A laboratory pedagogy interweaving weekly student portfolios with onsite formative electronic laboratory assessments (ELAs) is developed and assessed within the laboratory component of a required core course of the electrical and computer engineering (ECE) undergraduate curriculum. The approach acts to promote student outcomes, and neutralize…

Strategies for Creating Work-Based Learning Experiences in Schools for Secondary Students with Disabilities

ERIC Educational Resources Information Center

Cease-Cook, Jennifer; Fowler, Catherine; Test, David W.

2015-01-01

Nationally, the recent focus has been on adopting state-developed standards in English language arts (ELA) and mathematics that build toward college and career readiness. Of the states that have elected to adopt the Common Core State Standards (CCSS; National Governors Association, Council of Chief State School Officers, 2012), states either (a)…

Getting Past "Just Because": Teaching Writing in Science Class

ERIC Educational Resources Information Center

Grymonpre, Kris; Cohn, Allison; Solomon, Stacey

2012-01-01

How many times do teachers assign writing in science class only to be exasperated by their students' lack of writing skills? They often have difficulty making claims and using evidence; instead of explaining their reasoning, they state, "Just because." But teaching writing isn't just for English/language arts (ELA) class. Over the past two years,…

Aleksandar Kubičcela (1930-2017) - An Astrophysical Research Pioneer at the Astronomical Observatory of Belgrade

NASA Astrophysics Data System (ADS)

Popović, L. Č.; Vince, I.

2018-06-01

Here, we give a short biography and summary of scientific contributions of Aleksandar Kubičela, a doyen of astronomy in Serbia, and an astrophysical research pioneer at the Astronomical Observatory of Belgrade. Additionally, we evoke some of our memories concerning scientific collaboration with Aleksandar Kubičcela.

The Role of Teacher Instructional Discourse in Scaffolding Adolescent Students' Argumentation Strategy Use in Small Group Text-Based Discussions

ERIC Educational Resources Information Center

Anderson, Alyssa T. G.

2017-01-01

The goal of this study is to investigate the role of English Language Arts (ELA) teachers' verbal discourse moves in scaffolding adolescent students' argumentative thinking in small group interpretive discussions about literature. Demands related to argumentation may present particular challenges for adolescent students (Biancarosa & Snow,…

Looking at Citizenship through a Literary Lens

ERIC Educational Resources Information Center

Tavares, Laura

2017-01-01

President Barack Obama once said he believes that he learned how to be a good citizen by reading novels. In this article, Laura Tavares looks at the ways that ELA teachers can use fiction to illustrate social and ethical awareness, humility, and a tolerance for difference--all traits that are necessary to be a good citizen. By putting themselves…

Adolescents' Motivation in the Context of an Academic Vocabulary Intervention in Urban Middle School Classrooms

ERIC Educational Resources Information Center

Lesaux, Nonie K.; Harris, Julie Russ; Sloane, Phoebe

2012-01-01

In a large urban district's ELA classrooms, an academic vocabulary intervention designed to improve linguistically diverse 6th-graders' reading and language skills was implemented and evaluated. These classrooms were characterized by high numbers of struggling readers, and linguistic diversity was the norm. As part of the evaluation, this study…

15 CFR 748.4 - Basic guidance related to applying for a license.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION... sending of items out of the United States, except for Encryption License Arrangements (ELA) (see § 750.7(d... (Additional information) must be marked “748.4(b)(2)” to indicate that the power of attorney or other written...

15 CFR 748.4 - Basic guidance related to applying for a license.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION... sending of items out of the United States, except for Encryption License Arrangements (ELA) (see § 750.7(d... (Additional information) must be marked “748.4(b)(2)” to indicate that the power of attorney or other written...

Investigating Effective Teaching Methods for a Place-Based Teacher Preparation in a Rural Community

ERIC Educational Resources Information Center

Ajayi, Lasisi

2014-01-01

In this article, I argue for the need to improve teacher preparation (TP) courses for elementary education student teachers to teach English-language arts (ELA). In particular, these TP programs need to support student teachers in delivering culturally responsive pedagogy within rural classrooms. Twenty-three student teachers participated in this…

Exploring the Contribution of Classroom Formats on Teaching Effectiveness and Achievement in Upper Elementary Classrooms

ERIC Educational Resources Information Center

Baroody, Alison E.

2017-01-01

This study examined the contribution of classroom format on teaching effectiveness and achievement in English language arts (ELA) and mathematics. Secondary data analyses of the Measures of Effective Teaching database included 464 US classrooms. Classrooms were defined as self-contained if a generalist teacher provided instruction on all subjects…

Year 3 of Implementing the Common Core State Standards: Professional Development for Teachers and Principals

ERIC Educational Resources Information Center

Kober, Nancy; McIntosh, Shelby; Rentner, Diane Stark

2013-01-01

Timely, ongoing, and effective professional development for teachers and principals will be critical to the successful implementation of the Common Core State Standards (CCSS). These voluntary state-developed standards in mathematics and English language arts (ELA) outline the knowledge and skills that students in grades kindergarten through 12…

High School Teachers' Perspectives on the English Language Arts Common Core State Standards: An Exploratory Study

ERIC Educational Resources Information Center

Ajayi, Lasisi

2016-01-01

This was an exploratory study that examined high school teachers' perspectives about their early experiences with the English language arts Common Core State Standards. The sources of data for the study included a survey and structured interviews. Twenty-three high school ELA teachers from one unified school district in Southern California…

The Nature of Error in Adolescent Student Writing

ERIC Educational Resources Information Center

Wilcox, Kristen Campbell; Yagelski, Robert; Yu, Fang

2014-01-01

This study examined the nature and frequency of error in high school native English speaker (L1) and English learner (L2) writing. Four main research questions were addressed: Are there significant differences in students' error rates in English language arts (ELA) and social studies? Do the most common errors made by students differ in ELA…

The Influence of Classroom Drama on English Learners' Academic Language Use during English Language Arts Lessons

ERIC Educational Resources Information Center

Anderson, Alida; Loughlin, Sandra M.

2014-01-01

Teacher and student academic discourse was examined in an urban arts-integrated school to better understand facilitation of students' English language learning. Participants' discourse was compared across English language arts (ELA) lessons with and without classroom drama in a third-grade classroom of English learning (EL) students (N = 18) with…

The Academic Effects of Summer Instruction and Retention in New York City

ERIC Educational Resources Information Center

Mariano, Louis T.; Martorell, Paco

2013-01-01

This article examines the impacts of summer instruction and test-based grade retention in New York City. We use a research design that exploits test score cutoffs used in assignment to these treatments. We find modest positive effects of summer instruction on English language arts (ELA) achievement for students assigned to summer instruction…

Performance Assessment for California Teachers and English-Language Arts Candidates in a Rural Border Community

ERIC Educational Resources Information Center

Ajayi, Lasisi

2014-01-01

This study explores the appropriateness of the Performance Assessment for California Teachers (PACT) as an instrument of assessing English-language arts (ELA) teacher candidates' effectiveness in a rural border community. Eight -candidates participated in the study. The findings call into question the adequacy of PACT to assess the candidates'…

A Theoretical Investigation into the Inelastic Behavior of Metal-Matrix Composites

DTIC Science & Technology

1990-06-01

Part 13. Abstract (continued): for the constraining power of the matrix due to eigenstrain accumulation and anisotropy due to fiber reinforcement. The...1 CHAPTER II ELAS Method with Elastic Constraint ......................... 10 * 2.1 Eigenstrain Terminology...10 2.2 Fundamental Equations of Elasticity with Eigenstrains ......... 11 2.3 Eshelby’s Equivalent Inclusion Problem

Research for the Classroom: Mini Vocabulary Lessons for Maximum Recall

ERIC Educational Resources Information Center

Sovereen, Deanne

2013-01-01

"Research for the Classroom" publishes mini-studies of ELA classroom practices and suggests ways in which high school and middle school English teachers may study the effectiveness of their pedagogy. The author of this mini-study notes that it takes around six minutes per day of instructional time for students to remember most of the…

Methods and Strategies: Oral Science Stories. Using Culturally Responsive Storytelling to Teach Socioeconomically Disadvantaged Students

ERIC Educational Resources Information Center

Harris, Renard; Hall, Cynthia; Hawkins, Tristan; Hartley, Megan; McCray, Willie; Sirleaf, Hammed

2016-01-01

T.A.L.E.S., Teaching And Learning with Engaging Stories, is an alternative teaching method that focuses on enhancing learning by teaching science, math, ELA, and social studies through story. A six-week research study investigating socioeconomically disadvantaged students' responses to oral stories was conducted during an afterschool tutoring…

Does a Discussion by Any Other Name Sound the Same? Teaching Discussion in Three ELA Methods Courses

ERIC Educational Resources Information Center

Alston, Chandra L.; Danielson, Katie A.; Dutro, Elizabeth; Cartun, Ashley

2018-01-01

Facilitating discussions in English Language Arts can develop students' skills as speakers and listeners and their ability to engage with diverse perspectives. However, classroom observations often demonstrate a lack of student talk, raising questions about the complexity of facilitating discussion and teachers' opportunities to learn and hone the…

Graphic Novels in Advanced English/Language Arts Classrooms: A Phenomenological Case Study

ERIC Educational Resources Information Center

Gillenwater, Cary

2012-01-01

This dissertation is a phenomenological case study of two 12th grade English/language arts (ELA) classrooms where teachers used graphic novels with their advanced students. The primary purpose of this case study was to gain insight into the phenomenon of using graphic novels with these students--a research area that is currently limited.…

The Promise of Anonymity: An Investigation of the Practices of ELA Teachers Facilitating Discourse about LGBTQ Topics

ERIC Educational Resources Information Center

Kavanagh, Sarah Schneider

2016-01-01

Background/Context: As states and districts have begun adopting texts inclusive of lesbian, gay, bisexual, transgender, and queer (LGBTQ) people, debates about how LGBTQ issues should be represented in the curricular canon have emerged. While existing research investigates curricular questions that are arising as a result of LGBTQ curricular…

RAFTing with Raptors: Connecting Science, English Language Arts, and the Common Core State Standards

ERIC Educational Resources Information Center

Senn, Gary J.; McMurtrie, Deborah H.; Coleman, Bridget K.

2013-01-01

This article explores using the RAFT strategy (Role, Audience, Format, Topic) for writing in science classes. The framework of the RAFT strategy will be explained, and connections with Common Core State Standards (CCSS) for ELA/Literacy will be discussed. Finally, there will be a discussion of a professional learning experience for teachers in…

Examining Elementary Literacy Teachers' Perceptions of Their Preparedness to Implement the English Language Arts Common Core State Standards

ERIC Educational Resources Information Center

Adams-Budde, Melissa; Miller, Samuel

2015-01-01

The purpose of our study was to examine elementary literacy teachers' perceptions of their preparedness to implement the ELA CCSS [English Language Arts Common Core State Standards]. We defined preparedness across three dimensions: teachers' perceived levels of knowledge of the standards and its components; efficacy to implement changes; and…

Carpe Diem: Seizing the Common Core with Visual Thinking Strategies in the Visual Arts Classroom

ERIC Educational Resources Information Center

Franco, Mary; Unrath, Kathleen

2014-01-01

This article demonstrates how Visual Thinking Strategies (VTS) art discussions and subsequent, inspired artmaking can help reach the goals of the Common Core State Standards for English Language Arts & Literacy in History/Social Studies, Science, & Technical Subjects (CCSS-ELA). The authors describe how this was achieved in a remedial…

Disrupting Complacency: Helping Students Find Their Voices through Inquiry, Literature, and Technology

ERIC Educational Resources Information Center

Seglem, Robyn; Bonner, Sarah

2016-01-01

This article highlights an inquiry project in an eighth-grade ELA class in a rural middle school. Using the novel "Monster" by Walter Dean Myers, we encouraged students to form questions relating the text to the larger world. To begin the unit, students participated in three anchor activities over a three-week period. Students blogged…

English Education 2.0: An Analysis of Websites that Contain Videos of English Teaching

ERIC Educational Resources Information Center

Sherry, Michael Bruce; Tremmel, Robert

2012-01-01

In this article, we address how websites intended for ELA teachers encourage user participation and what kinds of English education these sites promote or exclude. We selected sites based on assumptions drawn from interactional sociolinguistics as well as additional criteria that developed during our search. Our analysis focuses on the George…

VITELLOGENIN GENE EXPRESSION IN FATHEAD MINNOWS AND PEARL DACE FROM CONTROL (NON-DOSED) AND LAKES DOSED WITH EE2 IN THE CANADIAN EXPERIMENTAL LAKES AREA

EPA Science Inventory

A whole-lake endocrine disruption experiment was conducted by Fisheries and Oceans Canada at the Experimental Lakes Area (ELA) in northwestern Ontario for three years beginning in 2001. This experiment examined population, organismal, biochemical and cellular-level effects in la...

From the Classroom: Implementing the Common Core in English Language Arts and in Mathematics: Practitioners' Perspectives

ERIC Educational Resources Information Center

VanTassel-Baska, Joyce; Johnsen, Susan K.

2016-01-01

At the 61st National Association for Gifted Children (NAGC) Annual Conference in Baltimore, Maryland, two practitioner panels responded to questions about implementing the Common Core in English language arts (ELA) and in mathematics. After listening to their responses, the authors felt that the "Gifted Child Today" readers would enjoy…

ELA Teacher Preparation 2.0: Critical Media Literacy, Action Research, and Mashups

ERIC Educational Resources Information Center

Laughter, Judson

2015-01-01

Engaging preservice English language arts interns in the analysis of mashups accomplishes two objectives: (a) it brings interns to a deeper understanding of action research and (b) provides a critical media literacy (CML) foundation on which they might build with their own students. In this paper CML is defined and recent literature is…

The Impact of Every Classroom, Every Day on High School Student Achievement: Results from a School-Randomized Trial

ERIC Educational Resources Information Center

Early, Diane M.; Berg, Juliette K.; Alicea, Stacey; Si, Yajuan; Aber, J. Lawrence; Ryan, Richard M.; Deci, Edward L.

2016-01-01

Every Classroom, Every Day (ECED) is a set of instructional improvement interventions designed to increase student achievement in math and English/language arts (ELA). ECED includes three primary components: (a) systematic classroom observations by school leaders, (b) intensive professional development and support for math teachers and…

High School Graduation Requirements in a Time of College and Career Readiness. CSAI Report

ERIC Educational Resources Information Center

Center on Standards and Assessments Implementation, 2016

2016-01-01

Ensuring that students graduate high school prepared for college and careers has become a national priority in the last decade. To support this goal, states have adopted rigorous college and career readiness (CCR) standards in English language arts (ELA) and mathematics. Additionally, states have begun to require students to pass assessments, in…

Readin', Writin', an' 'Rithmetic: Literacy Strategies in High School Mathematics

ERIC Educational Resources Information Center

Principato, Angela M.

2017-01-01

Stagnant growth on national standardized tests in mathematics and reading and a focus on disciplinary literacy in the Common Core State Standards in ELA, history/social studies, science, and technical subjects has prompted a resurgence in utilizing literacy strategies in the content areas in high school. While literacy standards in mathematics are…

From Print Texts to e-Books: The Changing Nature of Literacy

ERIC Educational Resources Information Center

Larson, Lotta

2013-01-01

This article describes ways that e-books, a common form of technology, can be used to differentiate instruction, enhance literacy learning, and support Common Core State English Language Arts (ELA) Standards at the fifth-grade level. However, the strategies described can easily be adapted to suit a wide range of grade levels and instructional…

Pleistocene glacial evolution of Fuentes Carrionas (Cantabrian Range, NW Spain)

NASA Astrophysics Data System (ADS)

Pellitero, Ramon

2014-05-01

Fuentes Carrionas is a massif situated at the N of Spain, between Castilla y Leon and Cantabria regions. It is the second highest mountain massif of the Cantabrian Range after Picos de Europa, with peaks over 2500 m.a.s.l. and valleys well over 1000 m.a.s.l. Fuentes Carrionas was glaciated during Quaternary, and even during the Holocene and as far as Little Ice Age the presence of glaciers, or at least permafrost is controversial. Results from glacial geomorphology analysis of Fuentes Carrionas Massif are presented. Based on the interpretation of glacial landforms, glacial evolution since the Last Glacial Maximum until Pleistocene deglaciation is described. Four different glacial equilibrium phases are identified, the last one divided into two pulsations. Deglaciation process took place between 36 ka BP and 11 ka BP. Local Last Glacial Maximum is dated back to 36-38 ka. BP, therefore earlier than LGM. Glaciers reached 15 km. long and occupied valleys down to 1250 m.a.s.l. during this phase. By European LGM (20-18 ka.BP) glaciers had substantially retreated to fronts about 1700 m.a.s.l. A final stage with two marked pulsations shows only small glaciers located at cirques above 2000 m.a.s.l. and, finally, only small cirque glaciers at North and Northeast orientation above 2200 m.a.s.l. Both these phases have been correlated to Oldest and Younger Dryas, although no dates have been done yet. A palaeoenvironmental reconstruction is proposed, based on ELA (Equilibrium Line Altitude) rise. ELA has been calculated with the AAR method and 0.67 ratio. This reconstruction shows that temperatures ranged between 9°C and 10°C lower than present ones at the end of Pleistocene, depending on a precipitations variation between 30% higher and 20% lower than current ones. Further research will focus on these retreat phases, especially on Younger Dryas identification and reconstruction for this site and the rest of Cantabrian Range.

Radical Islam in Latin America and the Caribbean: Implications for U.S. National Security

DTIC Science & Technology

2015-01-01

www.Newsmax.com/International/iran-missiles-venezu- ela/2008/12/22/id/327242/#ixzz3MfAmHOjT. 66. “Washington sanciona a Cavim for venta de tecnologia a Irán...El Universal, February 11, 2013, http://www.eluni- versal.com/nacional-y-politica/130211/washington-sanciona-a-cavim-por-venta-de- tecnologia -a-iran

On the Effectiveness of Pop-Up English Language Glossary Accommodations for EL Students in Large-Scale Assessments

ERIC Educational Resources Information Center

Cohen, Dale; Tracy, Ryan; Cohen, Jon

2017-01-01

This study examined the effectiveness and influence on validity of a computer-based pop-up English glossary accommodation for English learners (ELs) in grades 3 and 7. In a randomized controlled trial, we administered pop-up English glossaries with audio to students taking a statewide accountability English language arts (ELA) and mathematics…

Middle School Configuration Relationship with Eighth Grade Achievement with Administrator Perceptions of Strengths and Weaknesses

ERIC Educational Resources Information Center

Billings, Tawny J.

2014-01-01

This mixed-method research study sought to investigate the relationship between middle school configuration and the academic achievement of eighth grade students in English Language Arts (ELA) and Algebra 1. The California Content Standards exam scores of 646 elementary middle schools (K-8) and 1,282 traditional middle schools (6-8, 7-8) in…

The Impact of Poverty and School Size on the 2015-16 Kansas State Assessment Results

ERIC Educational Resources Information Center

Carter, Ted

2017-01-01

Schools with higher percentages of students in poverty have lower student assessment results on the 2015-16 Kansas Math and ELA assessments, and larger schools have lower student achievement results than smaller schools. In addition, higher poverty schools are likely to have larger gaps in performance based on special education status and possibly…

Teacher Perceptions and Use of Data-Driven Instruction: A Qualitative Study

ERIC Educational Resources Information Center

Melucci, Laura

2013-01-01

The purpose of this study was to determine how teacher perceptions of data and use of data-driven instruction affect student performance in English language arts (ELA). This study investigated teachers' perceptions of using data in the classroom and what supports they need to do so. The goal of the research was to increase the level of knowledge…

Experts and Novices Reading Literature: An Analysis of Disciplinary Literacy in English Language Arts

ERIC Educational Resources Information Center

Reynolds, Todd; Rush, Leslie S.

2017-01-01

The purpose of this pilot study is to examine how experts and novices in the study of literary texts read those texts, and to make suggestions for an English Language Arts (ELA) disciplinary literacy based on those findings. A small sample of experts and novices, four professors of literature and four college freshmen, participated in read-alouds…

Using Evidence-Based Conceptual Frameworks to Identify Leadership Practices of Principals of Successful Schools Serving English Learners

ERIC Educational Resources Information Center

Bishop, Robert C.

2013-01-01

This study is one of five thematic dissertations investigating the leadership practices of principals leading successful schools serving ELA learners. Schools selected for participation in this study had (a) an open enrollment policy, (b) at least 40% of total enrollment consists of ELL students, (c) has earned a School Performance Framework (SPF)…

Using Assessments to Inform 12th-Grade Interventions and Accelerations. ECS Education Policy Analysis

ERIC Educational Resources Information Center

Zinth, Jennifer; Millard, Maria

2015-01-01

In the 2014-15 school year, 47 states are administering high school assessments to gauge students' mastery of college and career readiness standards in English language arts (ELA) and math. These new assessments represent a departure from prior high school exams that measured acquisition of high school (or lower) content but provided no actionable…

The Relationship between Out-of-School-Suspension and English Language Arts Achievement of Students from Low Socio-Economic Settings

ERIC Educational Resources Information Center

Lobban, Carol Janet

2012-01-01

Out-of-school suspension (OSS) links low academic achievement to at risk students. Middle school students in one low socioeconomic urban setting experience lower academic achievement and higher rates of OSS. The purpose of this study was to determine the relationship between students' English Language Arts (ELA) achievement and OSS. Glasser's…

How Much English Language Arts and Mathematics Instruction Do Students Receive? Investigating Variation in Instructional Time

ERIC Educational Resources Information Center

Phelps, Geoffrey; Corey, Douglas; DeMonte, Jenny; Harrison, Delena; Loewenberg Ball, Deborah

2012-01-01

The amount of instruction students receive has long been viewed as a foundational educational resource. This article presents an analysis of the time students spend in elementary English language arts (ELA) and mathematics instruction. In mathematics, the average student received about 140 hr of instruction, but students in the top sixth of…

Reframing Equity under Common Core: A Commentary on the Text Exemplar List for Grades 9-12

ERIC Educational Resources Information Center

Schieble, Melissa

2013-01-01

This article provides a commentary on the text exemplar list for Grade bands 9-12 included in the Common Core documents in the United States. It is argued that a critical literacy perspective supports ELA teachers to assert a professional voice when making complex text selections based on diverse students' needs and interests. Implications…

A Value-Added Study of Teacher Spillover Effects across Four Core Subjects in Middle Schools

ERIC Educational Resources Information Center

Yuan, Kun

2015-01-01

This study examined the existence, magnitude, and impact of teacher spillover effects (TSEs) across teachers of four subject areas (i.e., mathematics, English language arts [ELA], science, and social studies) on student achievement in each of the four subjects at the middle school level. The author conducted a series of value-added (VA) analyses,…

How PARCC's False Rigor Stunts the Academic Growth of All Students. White Paper No. 135

ERIC Educational Resources Information Center

McQuillan, Mark; Phelps, Richard P.; Stotsky, Sandra

2015-01-01

In July 2010, the Massachusetts Board of Elementary and Secondary Education (BESE) voted to adopt Common Core's standards in English language arts (ELA) and mathematics in place of the state's own standards in these two subjects. The vote was based largely on recommendations by Commissioner of Education Mitchell Chester and then Secretary of…

The State of State Standards--and the Common Core--in 2010

ERIC Educational Resources Information Center

Carmichael, Sheila Byrd; Martino, Gabrielle; Porter-Magee, Kathleen; Wilson, W. Stephen

2010-01-01

This review of state English language arts (ELA) and mathematics standards is the latest in a series of Fordham evaluations dating back to 1997. It comes at a critical juncture, as states across the land consider adoption of the Common Core State Standards. These are the authors' major findings: (1) Based on their criteria, the Common Core…

The Achievement Progress of English Learner Students in Utah. REL 2016-155

ERIC Educational Resources Information Center

Haas, Eric; Huang, Min; Tran, Loan; Yu, Airong

2016-01-01

The purpose of this study was to examine the cumulative progress of English learner students in Utah in English language proficiency (ELP) and in academic content knowledge in both English language arts (ELA) and mathematics. This study identified students in grades kindergarten, 3, and 6 who were designated as English learner students in 2006/07…

Informational Text and the Common Core: A Content Analysis of Three Basal Reading Programs

ERIC Educational Resources Information Center

Walters, Barbara A.

2013-01-01

The Common Core State Standards for English Language Arts (CCSS-ELA) will have a significant impact on what teachers teach and what primary students are supposed to be able to do (Bomer & Maloch, 2011). By the end of fourth grade, reading instruction should be evenly balanced between literary text and informational text (NGA Center and CCSSO,…

The Critical Concepts. Final Version: English Language Arts, Mathematics, and Science

ERIC Educational Resources Information Center

Simms, Julia A.

2016-01-01

Research indicates that most standards documents articulate far more content than can be taught in the time available to K-12 teachers. In response, analysts at Marzano Research sought to identify, as objectively as possible, a focused set of critical concepts for each K-12 grade level in the content areas of English language arts (ELA),…

Reading & Listening with Purpose: Teaching Controversial Song Lyrics Using the ELA Common Core Standards in History/Social Studies

ERIC Educational Resources Information Center

Bender, Rachel A.; Sharp, Kimberlee A.

2013-01-01

This paper presents a method for social studies teachers to incorporate song lyrics into the study of controversial historical events and issues. Using the Hunt and Metcalf "Seven Problematic Areas of the Social Studies" as the rubric for selecting appropriate songs, the Teacher Candidate (TC) explains how song lyrics make viable text…

Turn It on and Turn It up: Incorporating Music Videos in the ELA Classroom

ERIC Educational Resources Information Center

Rodesiler, Luke

2009-01-01

The author advocates music videos as great sources for narrative and social commentary that can serve as excellent prompts for student writing. With access to personal artist websites, Yahoo! Music, YouTube, and MTV.com, students can view thousands of videos at their discretion, and English language arts teachers can bring them into the classroom…

Examining the Impact of Art-Based Anchor Charts on Academic Achievement in Language Arts

ERIC Educational Resources Information Center

Fontanez, Kimberly

2017-01-01

The students at 2 middle schools in County SD, NHMS and WMS are not scoring on or above grade level on the information text portion of the English Language Arts (ELA) standardized SC Palmetto Assessment of State Standards (SCPASS) test given annually in South Carolina. The teachers developed and implemented art-based anchor charts to help close…

The Effects of Implementing an Online Professional Learning Community for Teachers of Gifted and Talented Courses: An Action Research Study

ERIC Educational Resources Information Center

Mintz, Chelsey A.

2017-01-01

The purpose of this action research study was to examine the effects of implementing an online professional learning community (PLC) designed explicitly for teachers of gifted and talented (GT) English language arts (ELA) courses. The present action research (AR) is a limited mixed design study, including quantitative and qualitative elements, to…

Environmental Methods Review: Retooling Impact Assessment for the New Century

DTIC Science & Technology

1998-03-01

strategic environmental assessment (SEA), to support sustainable development. The International Study on the Effectiveness of Environmental...Directed by Barry Sadler, initiated and supported prominently by the Canadian Environmental Assessment Agency, and facilitated by IAIA, this study reviews...toward regional ElA,and vertically toward strategic and policy ElA; Larry Canter arrays twenty-two types of methods against seven typical study

Cleft palate and ADULT phenotype in a patient with a novel TP63 mutation suggests lumping of EEC/LM/ADULT syndromes into a unique entity: ELA syndrome.

PubMed

Prontera, Paolo; Garelli, Emanuela; Isidori, Ilenia; Mencarelli, Amedea; Carando, Adriana; Silengo, Margherita Cirillo; Donti, Emilio

2011-11-01

Acro-dermato-ungual-lacrimal-tooth (ADULT) syndrome is a rare condition belonging to the group of ectodermal dysplasias caused by TP63 mutations. Its clinical phenotype is similar to ectrodactyly-ectodermal dysplasia-cleft lip/palate (EEC) and limb-mammary syndrome (LMS), and differs from these disorders mainly by the absence of cleft lip and/or palate. We report on a 39-year-old patient who was found to be heterozygous for a c.401G > T (p.Gly134Val) de novo mutation of TP63. This patient had the ADULT phenotype associated with cleft palate. Our findings, rather than extend the clinical spectrum of ADULT syndrome, suggest that cleft palate can no longer be considered an element for differential diagnosis for ADULT, EEC, and LMS. Our data, added to other reports on overlapping phenotypes, support the combining of these three phenotypes into a unique entity that we propose to call "ELA syndrome," which is an acronym of ectrodactyly-ectodermal dysplasia-cleft lip and palate, limb-mammary, and ADULT syndromes. Copyright © 2011 Wiley Periodicals, Inc.

Sinus tarsi approach (STA) versus extensile lateral approach (ELA) for treatment of closed displaced intra-articular calcaneal fractures (DIACF): A meta-analysis.

PubMed

Bai, L; Hou, Y-L; Lin, G-H; Zhang, X; Liu, G-Q; Yu, B

2018-04-01

Our aim was to compare the effect of sinus tarsi approach (STA) vs extensile lateral approach (ELA) for treatment of closed displaced intra-articular calcaneal fractures (DIACF) is still being debated. A thorough research was carried out in the MEDLINE, EMBASE and Cochrane library databases from inception to December 2016. Only prospective or retrospective comparative studies were selected in this meta-analysis. Two independent reviewers conducted literature search, data extraction and quality assessment. The primary outcomes were anatomical restoration and prevalence of complications. Secondary outcomes included operation time and functional recovery. Four randomized controlled trials involving 326 patients and three cohort studies involving 206 patients were included. STA technique for DIACFs led to a decline in both operation time and incidence of complications. There were no significant differences between the groups in American Orthopedic Foot and Ankle Society scores, nor changes in Böhler angle. This meta-analysis suggests that STA technique may reduce the operation time and incidence of complications. In conclusion, STA technique is reasonably an optimal choice for DIACF. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

Timing of glacier advances and climate in the High Tatra Mountains (Western Carpathians) during the Last Glacial Maximum

NASA Astrophysics Data System (ADS)

Makos, Michał; Dzierżek, Jan; Nitychoruk, Jerzy; Zreda, Marek

2014-07-01

During the Last Glacial Maximum (LGM), long valley glaciers developed on the northern and southern sides of the High Tatra Mountains, Poland and Slovakia. Chlorine-36 exposure dating of moraine boulders suggests two major phases of moraine stabilization, at 26-21 ka (LGM I - maximum) and at 18 ka (LGM II). The dates suggest a significantly earlier maximum advance on the southern side of the range. Reconstructing the geometry of four glaciers in the Sucha Woda, Pańszczyca, Mlynicka and Velicka valleys allowed determining their equilibrium-line altitudes (ELAs) at 1460, 1460, 1650 and 1700 m asl, respectively. Based on a positive degree-day model, the mass balance and climatic parameter anomaly (temperature and precipitation) has been constrained for LGM I advance. Modeling results indicate slightly different conditions between northern and southern slopes. The N-S ELA gradient finds confirmation in slightly higher temperature (at least 1 °C) or lower precipitation (15%) on the south-facing glaciers during LGM I. The precipitation distribution over the High Tatra Mountains indicates potentially different LGM atmospheric circulation than at the present day, with reduced northwesterly inflow and increased southerly and westerly inflows of moist air masses.

Restriction fragment length polymorphism within the class I gene loci of the equine major histocompatibility complex

DOE Office of Scientific and Technical Information (OSTI.GOV)

Alexander, A.J.; Bailey, E.; Woodward, J.G.

1986-03-05

Fourteen standard bred horses were serotyped as homozygous for 1 of 6 Equine Leukocyte Antigen (ELA) specificities. DNA was purified from peripheral leukocytes and digested with Hind III or Pvu II. Southern blot hybridization analysis was carried out using a /sup 32/P-labeled mouse cDNA probe (PH2IIa) specific for class I MHC genes. Both enzymes generated blots that contained a large number of bands (23 to 30) per horse. Significant polymorphism existed among most fragment sizes, while a dozen highly conserved band sizes suggested the presence of Qa/tla - like genes. Only 2 animals (both W6's) showed identical band patterns. Polymorphismmore » was greatest between horses of different serotypes and was significantly decreased within serotypes. Unique bands were present on both blots for both W1's and W6's and may account for the serologic specificity seen in ELA W1 and W6 horses. This study is consistent with the findings in other higher vertebrates and implies that the MHC of the horse includes a highly polymorphic class I multigene family.« less

CSUNSat-1 Team working on their CubeSat at California State University Northridge

NASA Image and Video Library

2015-03-02

CSUNSat-1 Team (Adam Kaplan, James Flynn, Donald Eckels) working on their CubeSat at California State University Northridge. The primary mission of CSUNSat1 is to space test an innovative low temperature capable energy storage system developed by the Jet Propulsion Laboratory, raising its TRL level to 7 from 4 to 5. The success of this energy storage system will enable future missions, especially those in deep space to do more science while requiring less energy, mass and volume. This CubeSat was designed, built, programmed, and tested by a team of over 70 engineering and computer science students at CSUN.  The primary source of funding for CSUNSat1 comes from NASA’s Smallest Technology Partnership program. Launched by NASA’s CubeSat Launch Initiative NET April 18, 2017 ELaNa XVII mission on the seventh Orbital-ATK Cygnus Commercial Resupply Services (OA-7) to the International Space Station and deployed on tbd.

JPSS-1 P-Pod Installation

NASA Image and Video Library

2017-10-31

At Vandenberg Air Force Base in California, a Poly Picosatellite Orbital Deployer, or P-POD, container is installed on the Joint Polar Satellite System-1, or JPSS-1, spacecraft. P-PODS are auxiliary payloads launched aboard NASA expendable launch vehicles carrying up to three small CubeSats. The small cube-shaped satellites are part of NASA’s Educational Launch of Nanosatellite, or ELaNa, missions. The small payloads are designed and built by students from high school-level classes up to college and university students. JPSS is the first in a series of four next-generation environmental satellites in a collaborative program between the NOAA and NASA. Liftoff from Vandenberg's Space Launch Compex-2 atop a United Launch Alliance Delta II rocket is scheduled for 1:47 a.m. PST (4:47 a.m. EST), on Nov. 14, 2017.

JPSS-1 P-Pod Installation

NASA Image and Video Library

2017-10-31

At Vandenberg Air Force Base in California, technicians and engineers prepare to install a Poly Picosatellite Orbital Deployer, or P-POD, container on the Joint Polar Satellite System-1, or JPSS-1, spacecraft. P-PODS are auxiliary payloads launched aboard NASA expendable launch vehicles carrying up to three small CubeSats. The small cube-shaped satellites are part of NASA’s Educational Launch of Nanosatellite, or ELaNa, missions. The small payloads are designed and built by students from high school-level classes up to college and university students. JPSS is the first in a series of four next-generation environmental satellites in a collaborative program between the NOAA and NASA. Liftoff from Vandenberg's Space Launch Compex-2 atop a United Launch Alliance Delta II rocket is scheduled for 1:47 a.m. PST (4:47 a.m. EST), on Nov. 14, 2017.

JPSS-1 P-Pod Installation

NASA Image and Video Library

2017-10-31

At Vandenberg Air Force Base in California, technicians and engineers prepare a Poly Picosatellite Orbital Deployer, or P-POD, container for installation on the Joint Polar Satellite System-1, or JPSS-1, spacecraft. P-PODS are auxiliary payloads launched aboard NASA expendable launch vehicles carrying up to three small CubeSats. The small cube-shaped satellites are part of NASA’s Educational Launch of Nanosatellite, or ELaNa, missions. The small payloads are designed and built by students from high school-level classes up to college and university students. JPSS is the first in a series of four next-generation environmental satellites in a collaborative program between the NOAA and NASA. Liftoff from Vandenberg's Space Launch Compex-2 atop a United Launch Alliance Delta II rocket is scheduled for 1:47 a.m. PST (4:47 a.m. EST), on Nov. 14, 2017.

Glacial evolution of the Ampato Volcanic Complex (Peru)

NASA Astrophysics Data System (ADS)

Alcalá, J.; Palacios, D.; Zamorano, J. J.; Vázquez, L.

2009-04-01

Ice masses on the Western range of the Central Andes are a main source of water resources and act as a geoindicator of variations in the climate of the tropics (Mark, 2008). The study of their evolution is of particular interest since they are situated in the transition zone between the tropical and mid-latitude circulation areas of the atmosphere (Zech et al., 2007). The function of this transition area is currently under debate, and understanding it is essential for the development of global climate models (Kull et al, 2008; Mark, 2008). However our understanding of the evolution of glaciers and their paleoclimatic factors for this sector of the Central Andes is still at a very basic level. This paper presents initial results of a study on the glacial evolution of the Ampato volcanic complex (15°24´- 15° 51´ S, 71° 51´ - 73° W; 6288 m a.s.l.) located in the Western Range of the Central Andes in Southern Peru, 70 km NW of the city of Arequipa. The main objectives are to identify the number of glacial phases the complex has undergone using geomorphological criteria to define a time frame for each phase, based on cosmogenic 36Cl dating of a sequence of moraine deposits; and to estimate the glacier Equilibrium Line Altitude (ELA) of each phase. The Ampato volcanic complex is formed by 3 great andesitic stratovolcanoes, the Nevados HualcaHualca-Sabancaya-Ampato, which started forming between the late Miocene and early Quaternary (Bulmer et al., 1999), aligned N-S and with summits covered with glaciers. The Sabancaya volcano is fully active, with its latest eruption occurring in 2001. Glacial landforms were identified and mapped using photointerpretation of vertical aerial photographs from 1955 (1:35,000 scale, National Geographic Institute of Peru), oblique photographs from 1943 (Aerophotographical Service of Peru), and a geo-referenced high-resolution Mrsid satellite image from 2000 (NASA). This cartography was corrected and improved through fieldwork. It was then digitized in a Geographical Information System (GIS) using the existing 1:100,000 maps (National Geographical Institute of Peru) as a topographical base. Once the geomorphological maps had been analyzed, we decided to focus on the glacial evolution of a representative section of the Ampato Complex, specifically the Huayuray valley, located north of the HualcaHualca volcano. According to the altitudinal position and the degree of conservation of the moraines along the Quebrada, glacial phases of the Last Glacial Maximum (LGM), the Neoglacial and the Little Ice Age (LIA) were identified. The GIS was then used to delimit and calculate the ice surface area of each one. The same was also done for the years 1955 and 2000 AD, based on the interpretation of aerial photographs and satellite images from those years. Next, the ELA was calculated using the Altitude Area (AA) method (Osmaston, 2005) using GIS and the glacier paleotopography was reconstructed using geomorphological evidence (Carr, S & Coleman, C, 2007). To obtain numerical ages of moraine boulders and glacially abraded bedrock we applied cosmogenic36Cl surface exposure dating (Gosse & Phillips, 2001), which is the best method for volcanic rocks with no quartz content. Samples were collected from stable boulders located at the crests of moraine ridges and over 1 m in height. They were analyzed following procedures by Zreda et al. (1999) and Phillips (2003); physical analyses were undertaken at Universidad Complutense in Spain and physic-chemical analyses at the PRIME laboratory (Purdue University). LGM moraine forms always occupy the lowest altitude position, forming well-defined moraine arcs and ridges, with large dimensions and well preserved. During this phase, the climate was colder and damper than is currently the case in the Central Andes. Calculations show mean temperature during this period to have been 4 - 6°C below present values, and with more abundant precipitation (Seltzer et al., 2002). Under these climatic conditions, glaciers expanded and their fronts descended to a minimum altitude of 3900 m a.s.l. in the Huayuray valley. The ELA was at 4980 m a.s.l., implying an ELA depression of 900 m compared to the situation in 2000 AD. The age obtained for the Ampato Volcanic Complex using cosmogenic methods is 16,500 ± 0.37 y. AP, similar to the dates proposed by Clapperton (1993) - around 18,800 y. BP-, and far away from those proposed by Seltzer (2002) -30,000 y. BP- or by Smith et al. (2005) -21,000 y. BP-, although there is no certainty that the samples represent the oldest ridges of this period. Several records exist of Neoglacial advances, mainly well preserved moraines located in the glacial valleys immediately behind LGM moraines. One of these reached a minimum altitude of 4300 m a.s.l., with the ELA at 5240 m a.s.l., which implies an ELA depression of 560 m compared to the 2000 AD situation. 36Cl dating indicates that this Neoglacial advance occurred in 11,400 ± 0.21 y. BP. Two main glacial readvancement events due to climatic conditions have been noted in the Central Andes: The first between 15,000 and 13,000 yr. BP and the second at 12,000-10,000 yr. BP (Clapperton, 1993; Zech, et al., 2007). The latter has been dated with sufficient precision on the Chimborazo (Ecuador), the Junin Plains (Peru), and the Quelccaya Glacier (Peru) (Clapperton, 1993; Seltzer, 1990 and Smith et al. 2005) and corresponds to the described event in the Ampato Complex. There is limited data on the Little Ice Age for the Central Andes. This phase is represented by small moraines, located at high altitudes, very near the current glacial fronts. Ice cores extracted from some Central Andean glaciers, such as the Quelccaya Glacier (Peru), show a cooling episode between 1500 and 1820 AD, which corresponds to the LIA (Seltzer, 1990). During this recent global cold event, the minimum altitude of glaciers on the Ampato Volcanic Complex reached 5400 m a.s.l., 250 m below their 2000 position. The ELA is estimated at 5770 m a.s.l., with a depression of 110 m compared to 2000 AD. Existing ice masses on the Ampato are currently experiencing a substantial retreat. In 1955 the surface area they covered in the Huayuray valley was 2.45 km2, with an estimated ELA of 5800 m a.s.l., whereas by 2000 the area had been reduced to 1.45 km2 and the ELA climbed to 5887 m a.s.l.. In only 45 years, the glaciers have shrunk ~1 km2 and the ELA has raised 90 m. If the current trend continues, glaciers will have disappeared from this tropical mountain in approximately 65 years time. REFERENCES Bulmer, M.; Johnston, A. & Engle, F. (1999): Analysis of Sabancaya volcano, souther Peru using Radarsat and Landsat TM data. Application Development and Research Opportunity (ADRO), 10 pp. Carr, S & Coleman, C. (2007): An improved technique for the reconstruction of former glacier mass-balance and dynamics. Geomorphology, 92: 76-90. Clapperton, C. M. (1993). Quaternary Geology and Geomorphology of South America. Elservier, Amsterdam, 779 pp. Gosse, J.C.; y Phillips, F. M. (2001): Terrestrial in situ cosmogenic nuclides: theory and application. Quaternary Science Reviews 20: 1475-560. Mark, B. (2008): Tracing tropical Andean glaciers over space and time: Some lessons and transdisciplinary implications. Global and Planetary Change, 60: 101-114. Osmaston, H. (2005): Estimates of glacier equilibrium line altitudes by the Area Ã- Altitude, the Area Ã- Altitude Balance Ratio and the Area Ã- Altitude Balance Index Methods and their validation. Quaternary International, 138-139: 22-31. Phillips, F. M. (2003): Cosmogenic Cl36 ages of Quaternary basalt flows in the Mojave Desert, California, USA. Geomorphology, 53: 199-208. Kull, C.; Imhof, S.; Grosjean, M. y Veit, H. (2008): Late Pleistocene glaciations in the Central Andes: Temperature versus humidity control - A case study from the eastern Bolivian Andes (17° S) and regional synthesis. Global and Planetary Change (en prensa). Seltzer, G.O. (1990): Recent glacial history and paleoclimate of the Peruvian - Bolivian Andes. Quaternary Science Reviews, 9: 137-152. Seltzer, G. O.; Rodbell, D. T; Baker, P. A.; Fritz, S. C.; Tapia, P. M.; Rowe, H.D.; y Dunbar, R. B. (2002): Early warming of Tropical South America at the Last Glacial-Interglacial Transition. Science, 296: 1.685-1.686. Smith, J. A.; Seltzer, G.O.; Rodbell, R.T.; y Klein, A.R. (2005): Regional synthesis of last glacial maximum snowlines in the tropical Andes, South America. Quaternary International, 138: 145 -167. Zech, R.; Kull, CH.; Kubik, P. W. y Veit, H. (2007): Exposure dating of Late Glacial and pre-LGM moraines in the Cordon de Doña Rosa, Northern/Central Chile (31° S). Climate of the Past, 3: 1-14. Zech, R.; Kull, CH.; Kubik, P. W. y Veit, H. (2007): LGM and Late Glacial glacier advances in the Cordillera Real and Cochabamba (Bolivia) deduced from 10Be surface exposure dating. Climate of the Past, 3: 623-635. Zreda, M., J. England, F. Phillips, D. Elmore, and P. Sharma, (1999): Unblocking the Nares Strait by Greenland and Ellesmere ice-sheet retreat 10,000 years ago, Nature, 398: 139-142.

The Impact of the Norton High School Early College Program on the Academic Performance of Students at Norton High School

ERIC Educational Resources Information Center

Barba, Eric Matthew

2012-01-01

The purpose of this study was to evaluate the effect of the Norton High School Early College Early College Program on academic measures for students at Norton High School. Measures of achievement include the results of the English Language Arts (ELA), Mathematics, Social Science, and Science portions of the California Standards Test (CST), Student…

The Impact of 1:1 Laptop Environments on the English Language Arts Achievement of Fifth Grade Students from Diverse Socio-Economic Backgrounds

ERIC Educational Resources Information Center

Miller, Nicole Gilner

2017-01-01

This quantitative study extends previous research on the impact of one to one (1:1) laptop environments on student outcomes in English Language Arts (ELA) by focusing on students from various socio-economic backgrounds, while using a new technology-enhanced, state-administered assessment to measure performance. This study is significant because…

Accountability Policy Outcomes Related to No Child Left Behind and Educational Equity for Big5 City Schools in New York State

ERIC Educational Resources Information Center

Shin, Hyejin

2016-01-01

The purpose of this study was to explore the association of NCLB/accountability with educational output and input for New York State, collectively. Focusing on ELA and Math achievement in 4th and 8th grades, this study demonstrated the association of accountability outcomes in three ways: "accountability design, school proficiency level, and…

Engaging 21st-Century Adolescents: Video Games in the Reading Classroom

ERIC Educational Resources Information Center

Adams, Megan Glover

2009-01-01

Cross-age tutoring, in which older and younger students work together to improve their ELA skills, is not a new concept; Linda D. Labbo and William H. Teale explored it as a tool for poor readers as early as 1990. The author has found that using tutoring with video games also works well. Students have the opportunity to read aloud collaboratively…

The Effects of Targeted English Language Arts Instruction Using Multimedia Applications on Grade Three Students' Reading Comprehension, Attitude toward Computers, and Attitude toward School

ERIC Educational Resources Information Center

Swerdloff, Matthew

2013-01-01

The purpose of this study was to investigate the specific effects of targeted English Language Arts (ELA) instruction using multimedia applications. Student reading comprehension, student attitude toward computers, and student attitude toward school were measured in this study. The study also examined the perceptions, of selected students, of the…

State Test Score Trends through 2008-09, Part 5: Progress Lags in High School, Especially for Advanced Achievers

ERIC Educational Resources Information Center

McMurrer, Jennifer; Kober, Nancy

2011-01-01

This report by the Center on Education Policy (CEP), an independent nonprofit organization, examines trends in the achievement of high school students on the state reading/English language arts (ELA) and mathematics tests used for accountability under the No Child Left Behind Act (NCLB). In most states, these tests are first administered in grade…

Legal Rights in Education: Pendulum Swings. Papers [of the] Education Law Association (ELA) Annual Conference (44th, Charleston, South Carolina, November 19-21, 1998).

ERIC Educational Resources Information Center

Education Law Association, Dayton, OH.

This document is a collection of 32 1998 Education Law Association conference papers. The collection includes the following papers: "The More We Change: Meeting the Requirements of Unitary Status" (Angela M. Sewall and Ann E. Witcher); "Everything You Need To Know about Discipline of Students with Disabilities" (David T. Duff,…

The Disheartened Teacher: Living in the Age of Standardisation, High-Stakes Assessments, and No Child Left Behind (NCLB)

ERIC Educational Resources Information Center

Rubin, Daniel Ian

2011-01-01

There has been a universal movement towards government-regulated standardisation and high-stakes assessment. In the United States, this has resulted in the No Child Left Behind Act (2001). Because of the predominant focus on high-stakes reading and writing assessments required by NCLB, teachers in the subject area of English/Language Arts (ELA)…

Vocabulary Instruction and Mexican-American Bilingual Students: How Two High School Teachers Integrate Multiple Strategies to Build Word Consciousness in English Language Arts Classrooms

ERIC Educational Resources Information Center

Ajayi, Lasisi

2015-01-01

Despite the significance of vocabulary knowledge to student learning, limited studies have examined English language arts (ELA) teachers' skills and practices that may be effective for building word consciousness in high school Mexican-American bilingual students. The research objective of the present study is to examine how two high school ELA…

Year 3 of Implementing the Common Core State Standards: An Overview of States' Progress and Challenges

ERIC Educational Resources Information Center

Rentner, Diane Stark

2013-01-01

States are in a crucial phase of implementing the Common Core State Standards (CCSS), which outline the knowledge and skills that students in grades kindergarten through 12 are expected to learn in mathematics and English language arts (ELA) to be prepared for college and careers. As of July 2013, 45 states and the District of Columbia have…

Investigating the Relevance and Importance of English Language Arts Content Knowledge Areas for Beginning Elementary School Teachers. Research Memorandum No. RM-16-08

ERIC Educational Resources Information Center

Martin-Raugh, Michelle P.; Reese, Clyde M.; Phelps, Geoffrey C.; Tannenbaum, Richard J.; Steinberg, Jonathan H.; Xu, Jun

2016-01-01

The purpose of this report is to explore the content-related validity evidence supporting the English language arts (ELA) components of the "ETS"® National Observational Teaching Exam (NOTE) assessment series, a kindergarten through 6th-grade teacher licensure assessment. To establish the content knowledge required for the effective…

The Impact of the Great Recession on Student Achievement: Evidence from Population Data. CEPA Working Paper No. 17-09

ERIC Educational Resources Information Center

Shores, Kenneth; Steinberg, Matthew P.

2017-01-01

The Great Recession was the most severe economic downturn in the United States since the Great Depression. Using newly available population-level achievement data from the Stanford Education Data Archive (SEDA), we estimate the impact of the Great Recession on the math and English language arts (ELA) achievement of all grade 3-8 students in the…

Emerging Critical Meta-Awareness among Black and Latina/o Youth during Corrective Feedback Practices in Urban English Language Arts Classrooms

ERIC Educational Resources Information Center

Martinez, Danny C.

2017-01-01

This article addresses teachers' uptake of Black and Latina/o youth linguistic repertoires within the official space of an English Language Arts (ELA) classroom and how youth respond to corrective feedback that is focused on the form of their messages, rather than their function. Corrective feedback offered by one Latina teacher indexed larger…

Year 3 of Implementing the Common Core State Standards: States Prepare for Common Core Assessments

ERIC Educational Resources Information Center

Rentner, Diane Stark

2013-01-01

With the voluntary Common Core State Standards (CCSS), states have sought to establish clear, high expectations that are consistent across participating states and that signal what K-12 students should learn in mathematics and English language arts (ELA) to be prepared for college and careers. As of July 2013, the CCSS have been adopted by 45…

The Impact of Core Knowledge Curriculum on Reading Achievement in New York City Primary Public Schools

ERIC Educational Resources Information Center

Vafiadi, Polixeni

2010-01-01

Data published on the official website of the NYC DOE indicated that slightly less than half (42%) of NYC students in grades three through eight are not proficient in ELA, and one quarter of them (25%) are not proficient in Math. School reform based on Hirsch's Cultural Literacy provided an additional dimension to exploring school reform and…

The Learning School Approach and Student Proficiency in ELA and Math: Preliminary Findings. Catalyst Schools Research Study Report

ERIC Educational Resources Information Center

Hammer, Patricia Cahape

2016-01-01

The Learning School initiative completed its pilot testing in June 2016, with 28 schools, called catalyst schools, taking part. Catalyst schools were located in all eight regional education service agencies (RESAs) and were supported by RESA staff in implementing the Learning School approach. Five schools had been part of the program for 2 years…

The Shock and Vibration Digest. Volume 18, Number 12

DTIC Science & Technology

1986-12-01

practical msthods for fracture mechanics analysis. Linear elastic methods can yield useful results. Elas- dc-plasdc methods are becoming useful with...geometry factors. Fracture mechanics analysis based on linear elastic concepts developed in the 1960s has become established during the last decade as...2) is slightly conservative [2,3]. Materials that ran be treated with linear elastic fracture mechanics usually belong in this category. No

Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice.

PubMed

Hermann, Patrick C; Sancho, Patricia; Cañamero, Marta; Martinelli, Paola; Madriles, Francesc; Michl, Patrick; Gress, Thomas; de Pascual, Ricardo; Gandia, Luis; Guerra, Carmen; Barbacid, Mariano; Wagner, Martin; Vieira, Catarina R; Aicher, Alexandra; Real, Francisco X; Sainz, Bruno; Heeschen, Christopher

2014-11-01

Although smoking is a leading risk factor for pancreatic ductal adenocarcinoma (PDAC), little is known about the mechanisms by which smoking promotes initiation or progression of PDAC. We studied the effects of nicotine administration on pancreatic cancer development in Kras(+/LSLG12Vgeo);Elas-tTA/tetO-Cre (Ela-KRAS) mice, Kras(+/LSLG12D);Trp53+/LSLR172H;Pdx-1-Cre (KPC) mice (which express constitutively active forms of KRAS), and C57/B6 mice. Mice were given nicotine for up to 86 weeks to produce blood levels comparable with those of intermediate smokers. Pancreatic tissues were collected and analyzed by immunohistochemistry and reverse transcriptase polymerase chain reaction; cells were isolated and assayed for colony and sphere formation and gene expression. The effects of nicotine were also evaluated in primary pancreatic acinar cells isolated from wild-type, nAChR7a(-/-), Trp53(-/-), and Gata6(-/-);Trp53(-/-) mice. We also analyzed primary PDAC cells that overexpressed GATA6 from lentiviral expression vectors. Administration of nicotine accelerated transformation of pancreatic cells and tumor formation in Ela-KRAS and KPC mice. Nicotine induced dedifferentiation of acinar cells by activating AKT-ERK-MYC signaling; this led to inhibition of Gata6 promoter activity, loss of GATA6 protein, and subsequent loss of acinar differentiation and hyperactivation of oncogenic KRAS. Nicotine also promoted aggressiveness of established tumors as well as the epithelial-mesenchymal transition, increasing numbers of circulating cancer cells and their dissemination to the liver, compared with mice not exposed to nicotine. Nicotine induced pancreatic cells to acquire gene expression patterns and functional characteristics of cancer stem cells. These effects were markedly attenuated in K-Ras(+/LSL-G12D);Trp53(+/LSLR172H);Pdx-1-Cre mice given metformin. Metformin prevented nicotine-induced pancreatic carcinogenesis and tumor growth by up-regulating GATA6 and promoting differentiation toward an acinar cell program. In mice, nicotine promotes pancreatic carcinogenesis and tumor development via down-regulation of Gata6 to induce acinar cell dedifferentiation. Copyright © 2014 AGA Institute. Published by Elsevier Inc. All rights reserved.

Ligand conjugation to bimodal poly(ethylene glycol) brush layers on microbubbles.

PubMed

Chen, Cherry C; Borden, Mark A

2010-08-17

Using microbubbles as model systems, we examined molecular diffusion and binding to colloidal surfaces in bimodal poly(ethylene glycol) (PEG) brush layers. A microbubble is a gaseous colloidal particle with a diameter of less than 10 mum, of which the surface comprises amphiphilic phospholipids self-assembled to form a lipid monolayer shell. Due to the compressible gas core, microbubbles provide a sensitive acoustic response and are currently used as ultrasound contrast agents. Similar to the design of long circulating liposomes, PEG chains are typically incorporated into the shell of microbubbles to form a steric barrier against coalescence and adsorption of macromolecules to the microbubble surface. We introduced a buried-ligand architecture (BLA) design where the microbubble surface was coated with a bimodal PEG brush. After microbubbles were generated, fluorescent ligands with different molecular weights were conjugated to the tethered functional groups on the shorter PEG chains, while the longer PEG chains served as a shield to protect these ligands from exposure to the surrounding environment. BLA microbubbles reduced the binding of macromolecules (>10 kDa) to the tethers due to the steric hindrance of the PEG overbrush while allowing the uninhibited attachment of small molecules (<1 kDa). Roughly 40% less fluorescein-conjugated streptavidin (SA-FITC) bound to BLA microbubbles compared to exposed-ligand architecture (ELA) microbubbles. The binding of SA-FITC to BLA microbubbles suggested a possible phase separation between the lipid species on the surface leading to populations of revealed and concealed ligands. Ligand conjugation kinetics was independent of microbubble size, regardless of ligand size or microbubble architecture. We observed, for the first time, streptavidin-induced surface structure formation for ELA microbubbles and proposed that this phenomenon may be correlated to flow cytometry scattering measurements. We therefore demonstrated the feasibility of postlabeling for small-molecule ligands to BLA microbubbles to generate stealth targeted ultrasound contrast agents.

Glacial recession in the Tropical Andes from the Little Ice Age: the case of Ampato Volcanic Complex (Southern Peru

NASA Astrophysics Data System (ADS)

Alcalá, J.; Palacios, D.; Zamorano, J. J.

2010-03-01

Data published over the last decade reveal substantial glacial recession in the tropical Andes since the Little Ice Age (LIA), (Ramirez, et al., 2001; Rabatel, et al., 2005; Rabatel, et al., 2008; Vuille, et al., 2008; Hastenrath, 2009; Jomelli, et al., 2009), and a growing rate of recession since the 1980’s caused by global warming (Ramirez, et al., 2001; Vuille, et al., 2008). Today there is great interest in the evolution of these ice masses due to heightened awareness of climate change and of the strategic importance that glaciers have as a hydrologic resource for communities in arid climate zones in the tropical Andes (Mark, 2008; Vuille et al., 2008). Cordillera Blanca forms part of the Andes Mountains of northern Peru, and is a chosen site for many studies on glacier evolution. Vuille et al. 2008 determined that a considerable area of ice mass was lost at Huascarán-Chopicalqui glacier (18% from 1920-1970) and Astesonraju glacier (20% from 1962-2003). Studies at Coropuna volcano, which has the most extensive glacier field in the western range of southern Peru, also report a strong melting trend that began with only minimal recession from 1955-1986 (4%), but increased to 14% from 1986-2007 (Úbeda et al., 2009). Only a few of the Andes glaciers are consistently monitored, and the most comprehensive data are for Chacaltaya and Zongo glaciers (16º S) in Bolivia. Since the maximum LIA, Chacaltaya has lost 89% of its surface area, particularly in recent years. By 1983, the totaled loss was five times the shrinkage for the period 1940-1963 (Ramirez, et al., 2001). Zongo glacier maintained equilibrium from 1956-1975, but later experienced a period dominated by continuous recession (Soruco, et al., 2009). This study expands current knowledge of glacier evolution since the LIA in the Central Volcanic Zone (CVZ; 14º - 27º S) (Stern, 2004) of the Andes. The study site was chosen in an area that had never been used for preliminary research of this type, concretely the Ampato volcanic complex (15º24´- 15º 51´ S, 71º 51´ - 73º W; 6.288 masl), one of the most important complexes of the northern sector of the CVZ. Photointerpretation of aerial photographs and teledetection through satellite images of Huayuray Valley (15º 41´ 14´´ S - 71º 51´ 53´´ W), located to the north of the complex, aided in accurately reconstructing the area occupied by the ice mass at different times (LIA, 1955, 2000 and 2008). Also the paleo-ELA (Equilibrium Line Altitude) and the ELA were calculated using the Accumulation Area (AA) method (Kaser and Osmaston, 2002; Osmaston, 2005) in a GIS. The ELA shows the relationship between climate and glacier mass balance (González Trueba, 2005). The data from Huayuray Valley show that the glaciers reached a minimum altitude of 5400 masl and covered an area of ~2.81 Km2 during the LIA. The paleo-ELA was located at ~5780 masl, ~120 m below the current ELA (~5900 m). Based on a vertical thermal gradient of 0.65ºC/100 m, the temperature during this event would have been about 0.7º C colder than present temperature in the Ampato volcanic complex. In 1955, Huayuray glacier covered ~2.45 km2, 12.8% less than in the LIA. In the same year, the glaciers in the Huayuray valley reached a minimum elevation of ~5660 masl and the ELA rose ~20 m, to 5800 masl. In only 45 years (1955 - 2000) the surface area of the ice was significantly reduced (~1 km2), i.e. 40.8%. The ELA continued to rise, until it reached 5890 masl in 2000. From 2000 - 2008, the Huayuray glacier was reduced to ~0.78 km2 and the ELA rised ~10 m to reach the 5900 masl These results from the CVZ confirm the dramatic recession of the glaciers in the tropical Andes during recent decades. They also suggest that if the rate of recession associated with the period 2000-2008 continues, glaciers in the Ampato volcanic complex will disappear in 10 years approximately. References González Trueba, J.J. (2005): La Pequeña Edad del Hielo en los Picos de Europa (Cordillera Cantábrica, NO de España). Análisis morfológico y reconstrucción del avance glaciar histórico. Rev. C & G., 19 (3-4), 79-94. Hastenrath, S. L. (2009): Past glaciation in the tropics. Quaternary Science Reviews, 28: 790-798. Jomelli, V.; Favier, V.; Rabatel, A.; Brunstein, D.; Hoffmann, G.; and Francou, B. (2009): Fluctuations of glaciers in the tropical Andes over the last millennium and palaeoclimatic implications: A review. Palaeogeography, Palaeoclimatology, Palaeoecology, doi: 10.1016/j.palaeo.2008.10.033. Kaser, G., Osmaston, H.A., 2002. Tropical glaciers. Cambridge University Press, Cambridge. Mark, B. (2008): Tracing tropical Andean glaciers over space and time: Some lessons and transdisciplinary implications. Global and Planetary Change, 60: 101-114. Osmaston, H. (2005): Estimates of glacier equilibrium line altitudes by the Area _ Altitude, the Area _ Altitude Balance Ratio and the Area _ Altitude Balance Index Methods and their validation. Quaternary International, 138-139: 22-31. Rabatel, A., Jomelli, V., Naveau, P., Francou, B., Grancher, D. (2005). Dating of Little Ice Age glacier fluctuations in the tropical Andes: Charquini glaciers, Bolivia, 16ºS. C. R. Geoscience, 337: 1311-1322. Rabatel, A., Francou, B., Jomelli, V., Naveau, P., Grancher, D. (2008). A chronology of the Little Ice Age in the tropical Andes of Bolivia (16º S) and its implications for climate reconstruction. Quaternary Research, 70: 198-212. Ramirez, E., Francou, B., Ribstein, P., Descloitres, M., Guerin, R., Mendoza, J., Gallaire, R., Pouyaud, B., Jordan, E., 2001. Small glaciers disappearing in the tropical Andes: a case study in Bolivia: Glaciar Chacaltaya (16°S). Journal of Glaciology 47 (157), 187-194. Soruco, A.; Vincent, C.; Francou, B.; Ribstein, P.; Berger, T.; Sicart, J. E.; Wagnon, P.; Arnaud, Y.; Favier, V.; and Lejeune, Y. (2009): Mass balance of Glacier Zongo, Bolivia, between 1956 and 2006, using glaciological, hydrological and geodetic methods. Annals of Glaciology, 50. Stern, C. R. (2004): Active Andean volcanism: it’s geologic and tectonic setting. Revista Geológica de Chile, 31: 161-206. Úbeda, J., Palacios D., Vazquez L. (2009 a) Reconstruction of Equilibrium Line Altitudes of Nevado Coropuna Glaciers (Southern Peru) from the Late Pleistocene to the present. Geophysical Research Abstracts, 11, EGU2009-8067-2, Vuille, M.; Francou, B.; Wagnon, P.; Juen, I. ; Kaser, G. ; Mark, B. ; y Bradley, R. (2008) : Climate change and tropical Andean glaciers : Past, present and future. Earth-Science Reviews, 89: 79-96.

"I'm Not Teaching English, I'm Teaching Something Else!": How New Teachers Create Curriculum under Mandates of Educational Reform

ERIC Educational Resources Information Center

Costigan, Arthur

2018-01-01

This study presents how beginning teachers create and teach an English Language Arts (ELA) curriculum in urban schools in the context of an educational reform movement driven by mandates such as Common Core State Standards (CCSS), high stakes tests, and prescribed curricula. They serve in schools with each using unique and individual curricula due…

Principal Professional Learning Community Behavior in Low Wealth High Schools with Higher and Lower Student Achievement as Measured by Mastery Scores on the New York State Eleventh Grade ELA Regents Exam

ERIC Educational Resources Information Center

Adams, Adrian

2016-01-01

This study was designed to analyze non-principal staff supervisors' perceptions of PLC efforts, encouragements, and activities in the six dimensions of a professional learning community (PLC) characterized as shared and supportive leadership, shared values and vision, collaborative culture, a focus on learning, supportive relationships, and…

What Makes Teachers "TIK"? A Study of Secondary Teacher Integrated Knowledge and Change in 1:1 iPad Classrooms

ERIC Educational Resources Information Center

Hamilton, Erica R.

2014-01-01

This yearlong, multi-case qualitative study examined the experiences of four secondary teachers who taught in a school where each student had an iPad tablet computer (1:1 iPad). The teachers taught four different subjects (i.e., English Language Arts (ELA), Social Studies, Spanish, and Chemistry). They ranged from 8 to 30 years of teaching…

How Business Leaders Can Support College and Career-Readiness: Staying the Course on Common Core. White Paper

ERIC Educational Resources Information Center

Meyer, Lori

2014-01-01

For the first time in the nation's history, a majority of students in the United States are learning based on a common set of standards for mathematics and English language arts (ELA) that will prepare them for the demands of the 21st century. The Common Core State Standards (CCSS) provide a clear, consistent framework for what students should…

How Much Do Test Scores Vary among School Districts? New Estimates Using Population Data, 2009-2015. CEPA Working Paper No. 17-02

ERIC Educational Resources Information Center

Fahle, Erin M.; Reardon, Sean F.

2017-01-01

This paper provides the first population-based evidence on how much standardized test scores vary among public school districts within each state and how segregation explains that variation. Using roughly 300 million standardized test score records in math and ELA for grades 3 through 8 from every U.S. public school district during the 2008-09 to…

Correlation between Grades 4th, 8th, and 11th English Language Arts Scores and High School Graduation

ERIC Educational Resources Information Center

Parese, Errin C.

2014-01-01

The focus of this research was on students' low graduation rate in a New York State high school, investigating a possible correlation between students' longitudinal English Language Arts (ELA) exams and their graduation status. In the 2010-11 school year, 25% of the students at the high school of study failed to graduate, a rate which was 5% lower…

Analyses of pancreas development by generation of gfp transgenic zebrafish using an exocrine pancreas-specific elastaseA gene promoter

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wan Haiyan; Korzh, Svitlana; Li Zhen

2006-05-15

In contrast to what we know on development of endocrine pancreas, the formation of exocrine pancreas remains poorly understood. To create an animal model that allows observation of exocrine cell differentiation, proliferation, and morphogenesis in living animals, we used the zebrafish elastaseA (elaA) regulatory sequence to develop transgenic zebrafish that display highly specific exocrine pancreas expression of GFP in both larvae and adult. By following GFP expression, we found that the pancreas in early development was a relatively compact organ and later extended posterior along the intestine. By transferring the elaA:gfp transgene into slow muscle omitted mutant that is deficientmore » in receiving Hedgehog signals, we further showed that Hedgehog signaling is required for exocrine morphogenesis but not for cell differentiation. We also applied the morpholino knockdown and toxin-mediated cell ablation approaches to this transgenic line. We showed that the development of exocrine pancreas is Islet-1 dependent. Injection of the diphtheria toxin A (DTA) construct under the elastaseA promoter resulted in selective ablation of exocrine cells while the endocrine cells and other endodermal derivatives (liver and intestine) were not affected. Thus, our works demonstrated the new transgenic line provided a useful experimental tool in analyzing exocrine pancreas development.« less

Maternal smoking during pregnancy and failure of the georgia first grade criterion-referenced competency test.

PubMed

Feng, Jia; Kramer, Michael R; Dever, Bridget V; Dunlop, Anne L; Williams, Bryan; Jain, Lucky

2013-05-01

Maternal smoking during pregnancy (MSDP) has been reported to be associated with impaired measures of cognitive function, but it remains unclear whether exposure to MSDP has an impact upon offspring school performance. We examined the association between MSDP and failure of the Criterion-Referenced Competency Tests (CRCT) among Georgia first grade students. A retrospective cohort was created by deterministically linking 331 531 children born in Georgia from 1998 to 2002 (inclusive) to their individual CRCT education records from 2005 to 2009. We evaluated the association between MSDP (yes/no) and failure of the CRCT Reading, English/Language Arts (ELA), and Mathematics tests, with adjustment for maternal and child sociodemographic characteristics and birth outcomes. Log-binomial models estimated the risk ratios and 95% confidence intervals. Conditional models were fitted to paired sibling data. MSDP was associated with CRCT failure with an adjusted risk ratios for Reading: 1.16 [95% CI 1.12, 1.21]; ELA: 1.12 [95%CI 1.10, 1.15]; and Mathematics: 1.13 [95%CI 1.10, 1.16]. The association remained significant in paired sibling analyses. MSDP may have independent long-term effects on offspring school performance, which does not appear to be through smoking-related adverse birth outcomes. © 2013 Blackwell Publishing Ltd.

Improving classroom quality with the RULER Approach to Social and Emotional Learning: proximal and distal outcomes.

PubMed

Hagelskamp, Carolin; Brackett, Marc A; Rivers, Susan E; Salovey, Peter

2013-06-01

The RULER Approach to Social and Emotional Learning ("RULER") is designed to improve the quality of classroom interactions through professional development and classroom curricula that infuse emotional literacy instruction into teaching-learning interactions. Its theory of change specifies that RULER first shifts the emotional qualities of classrooms, which are then followed, over time, by improvements in classroom organization and instructional support. A 2-year, cluster randomized controlled trial was conducted to test hypotheses derived from this theory. Sixty-two urban schools either integrated RULER into fifth- and sixth-grade English language arts (ELA) classrooms or served as comparison schools, using their standard ELA curriculum only. Results from multilevel modeling with baseline adjustments and structural equation modeling support RULER's theory of change. Compared to classrooms in comparison schools, classrooms in RULER schools exhibited greater emotional support, better classroom organization, and more instructional support at the end of the second year of program delivery. Improvements in classroom organization and instructional support at the end of Year 2 were partially explained by RULER's impacts on classroom emotional support at the end of Year 1. These findings highlight the important contribution of emotional literacy training and development in creating engaging, empowering, and productive learning environments.

Validation of a Custom-made Software for DQE Assessment in Mammography Digital Detectors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ayala-Dominguez, L.; Perez-Ponce, H.; Brandan, M. E.

2010-12-07

This works presents the validation of a custom-made software, designed and developed in Matlab, intended for routine evaluation of detective quantum efficiency DQE, according to algorithms described in the IEC 62220-1-2 standard. DQE, normalized noise power spectrum NNPS and pre-sampling modulation transfer function MTF were calculated from RAW images from a GE Senographe DS (FineView disabled) and a Siemens Novation system. Calculated MTF is in close agreement with results obtained with alternative codes: MTF lowbar tool (Maidment), ImageJ plug-in (Perez-Ponce) and MIQuaELa (Ayala). Overall agreement better than {approx_equal}90% was found in MTF; the largest differences were observed at frequencies closemore » to the Nyquist limit. For the measurement of NNPS and DQE, agreement is similar to that obtained in the MTF. These results suggest that the developed software can be used with confidence for image quality assessment.« less

Climate dominated topography in a tectonically active mountain range

NASA Astrophysics Data System (ADS)

Adams, B. A.; Ehlers, T. A.

2015-12-01

Tests of the interactions between tectonic and climate forcing on Earth's topography often focus on the concept of steady-state whereby processes of rock deformation and erosion are opposing and equal. However, when conditions change such as the climate or tectonic rock uplift, then surface processes act to restore the balance between rock deformation and erosion by adjusting topography. Most examples of canonical steady-state mountain ranges lie within the northern hemisphere, which underwent a radical change in the Quaternary due to the onset of widespread glaciation. The activity of glaciers changed erosion rates and topography in many of these mountain ranges, which likely violates steady-state assumptions. With new topographic analysis, and existing patterns of climate and rock uplift, we explore a mountain range previously considered to be in steady-state, the Olympic Mountains, USA. The broad spatial trend in channel steepness values suggests that the locus of high rock uplift rates is coincident with the rugged range core, in a similar position as high temperature and pressure lithologies, but not in the low lying foothills as has been previously suggested by low-temperature thermochronometry. The details of our analysis suggest the dominant topographic signal in the Olympic Mountains is a spatial, and likely temporal, variation in erosional efficiency dictated by orographic precipitation, and Pleistocene glacier ELA patterns. We demonstrate the same topographic effects are recorded in the basin hypsometries of other Cenozoic mountain ranges around the world. The significant glacial overprint on topography makes the argument of mountain range steadiness untenable in significantly glaciated settings. Furthermore, our results suggest that most glaciated Cenozoic ranges are likely still in a mode of readjustment as fluvial systems change topography and erosion rates to equilibrate with rock uplift rates.

Trends in annual minimum exposed snow and ice cover in High Mountain Asia from MODIS

NASA Astrophysics Data System (ADS)

Rittger, Karl; Brodzik, Mary J.; Painter, Thomas H.; Racoviteanu, Adina; Armstrong, Richard; Dozier, Jeff

2016-04-01

Though a relatively short record on climatological scales, data from the Moderate Resolution Imaging Spectroradiometer (MODIS) from 2000-2014 can be used to evaluate changes in the cryosphere and provide a robust baseline for future observations from space. We use the MODIS Snow Covered Area and Grain size (MODSCAG) algorithm, based on spectral mixture analysis, to estimate daily fractional snow and ice cover and the MODICE Persistent Ice (MODICE) algorithm to estimate the annual minimum snow and ice fraction (fSCA) for each year from 2000 to 2014 in High Mountain Asia. We have found that MODSCAG performs better than other algorithms, such as the Normalized Difference Index (NDSI), at detecting snow. We use MODICE because it minimizes false positives (compared to maximum extents), for example, when bright soils or clouds are incorrectly classified as snow, a common problem with optical satellite snow mapping. We analyze changes in area using the annual MODICE maps of minimum snow and ice cover for over 15,000 individual glaciers as defined by the Randolph Glacier Inventory (RGI) Version 5, focusing on the Amu Darya, Syr Darya, Upper Indus, Ganges, and Brahmaputra River basins. For each glacier with an area of at least 1 km2 as defined by RGI, we sum the total minimum snow and ice covered area for each year from 2000 to 2014 and estimate the trends in area loss or gain. We find the largest loss in annual minimum snow and ice extent for 2000-2014 in the Brahmaputra and Ganges with 57% and 40%, respectively, of analyzed glaciers with significant losses (p-value<0.05). In the Upper Indus River basin, we see both gains and losses in minimum snow and ice extent, but more glaciers with losses than gains. Our analysis shows that a smaller proportion of glaciers in the Amu Darya and Syr Darya are experiencing significant changes in minimum snow and ice extent (3.5% and 12.2%), possibly because more of the glaciers in this region are smaller than 1 km2 than in the Indus, Ganges, and Brahmaputra making analysis from MODIS (pixel area ~0.25 km2) difficult. Overall, we see 23% of the glaciers in the 5 river basins with significant trends (in either direction). We relate these changes in area to topography and climate to understand the driving processes related to these changes. In addition to annual minimum snow and ice cover, the MODICE algorithm also provides the date of minimum fSCA for each pixel. To determine whether the surface was snow or ice we use the date of minimum fSCA from MODICE to index daily maps of snow on ice (SOI), or exposed glacier ice (EGI) and systematically derive an equilibrium line altitude (ELA) for each year from 2000-2014. We test this new algorithm in the Upper Indus basin and produce annual estimates of ELA. For the Upper Indus basin we are deriving annual ELAs that range from 5350 m to 5450 m which is slightly higher than published values of 5200 m for this region.

'Sometimes They Are Fun and Sometimes They Are Not': Concept Mapping with English Language Acquisition (ELA) and Gifted/Talented (GT) Elementary Students Learning Science and Sustainability

ERIC Educational Resources Information Center

Marzetta, Katrina; Mason, Hillary; Wee, Bryan

2018-01-01

This study presents an 'education for sustainability' curricular model which promotes science learning in an elementary classroom through equity pedagogy. A total of 25 fourth-grade students from an urban, public school in Denver, Colorado participated in this mixed-methods study where concept maps were used as a tool for describing and assessing…

Why Massachusetts Should Abandon the PARCC Tests and the 2011 Coleman et al English Language Arts Standards on Which the MCAS Tests Are Based. Testimony

ERIC Educational Resources Information Center

Stotsky, Sandra

2015-01-01

In this testimony, the author first describes her qualifications, as well as the lack of relevant qualifications in Common Core's standards writers and in most of the members of Common Core's Validation Committee, on which she served in 2009-2010. The author then details some of the many problems in the 2011 Massachusetts ELA standards, written by…

The Salt-Gradient Solar Pond.

DTIC Science & Technology

1983-02-01

X rGP)**2H1*(DEFH+X1 UP)(i... X CP( *(E-’PfH+XTGP]/lo) 10851) y 1000)i(IC tZE*X~GT*0.) 109001 11110 D( I )= (,,+* IELT *PtH1 ( 2) 2/ .o+4LX ) ( I.’(Q...2.*LLX**2)( I.-(0*DRbT)/(DELX 12100 _. D *42)) +PhI()+((* iELT )/(2.*(.ELA*42) ))PHI(T-1)+(EELT/2.. -1 2 3 0 9 ... . . .... ---(1 I

Noise Abatement and Internal Vibrational Absorption in Potential Structural Materials

DTIC Science & Technology

1975-03-01

martensitic transformation tempera- ture ranges. In contrast, much acoustic activity was detected dur- ing transformation in experiments using 7^ P...S0 Hi alloys in which "burst-type" martensitic transformation is known to occur (4). The above experiments indicate that the mechanism of... martensitic trans- formation in the highly damping NiTi alloys is of the thermo-elas- tic mode. In order to establish a stable transformation behavior as

Generalized Equations and Their Solutions. Part 2. Applications to Nonlinear Programming

DTIC Science & Technology

1980-03-01

7901066. Parts of the research for this paper were carried out at the Departement de Mathematiques elaD n Uversite Paris-IX Dauphine, with financial...support from the Centre National de la Recherche Scientifique, and at the Departamento de Matematicas y Ciencias de la Computaci6 n, Universidad Simon...Bolivar, Caracas, Venezuela, with support from the United Nations Educational, Scientific and Cultural Organization under Proyecto UNESCO VEN-77-002. The

Temperature Compensated Piezoelectric Materials

DTIC Science & Technology

1982-09-01

modeling of the dielectric, elas- tic, piezoelectric and thermoelectric properties of a simple proper ferroelec- tric. In the thermodynamic...COMPOSITIONS 61 5.1 Growth of Sro.sBao.sNbaOe Thin Films 61 5.2 Growth of SraKNbsOis Thin Films 63 6.0 STRUCTURAL.AND FERROELECTRIC PROPERTIES OF...Transitions 75 6.4 Ferroelectric Data 77 6.5 Concl usi ons 82 7.0 PHOTOREFRACTIVE PROPERTIES OF SBN SINGLE CRYSTALS 85 8.0 PUBLICATIONS AND

PARCC Accessibility Features and Accommodations Manual: Guidance for Districts and Decision-Making Teams to Ensure That PARCC Summative Assessments Produce Valid Results for All Students. Fourth Edition

ERIC Educational Resources Information Center

Bowman, Trinell; Wiener, Daniel; Branson, Danielle

2015-01-01

The Partnership for Assessment of Readiness for College and Careers (PARCC) is a group of states working together to develop a set of assessments that measure whether students are on track to be successful in college and their careers. These high-quality, computer-based K-12 assessments in mathematics and English language arts (ELA)/literacy give…

English Second Language, General, Special Education, and Speech/Language Personal Teacher Efficacy, English Language Arts Scientifically-Validated Intervention Practice, and Working Memory Development of English Language Learners in High and Low Performing Elementary Schools

ERIC Educational Resources Information Center

Brown, Barbara J.

2013-01-01

The researcher investigated teacher factors contributing to English language arts (ELA) achievement of English language learners (ELLs) over 2 consecutive years, in high and low performing elementary schools with a Hispanic/Latino student population greater than or equal to 30 percent. These factors included personal teacher efficacy, teacher…

An eleven-year record of mass balance of Brewster Glacier, New Zealand, determined using a geostatistical approach

NASA Astrophysics Data System (ADS)

Cullen, N. J.; Anderson, B.; Sirguey, P. J.; Stumm, D.; Mackintosh, A.; Conway, J. P.; Horgan, H. J.; Dadic, R.; Fitzsimons, S.; Lorrey, A.

2016-12-01

Recognizing the scarcity of glacier mass balance data in the Southern Hemisphere, a mass balance measurement program was started at Brewster Glacier in 2004. Evolution of the measurement regime over the 11 years of data recorded means there are differences in the spatial density of data obtained. To ensure the temporal integrity of the dataset a new, geostatistical approach has been developed to calculate mass balance. Spatial co-variance between elevation and snow depth has enabled a digital elevation model to be used in a co-kriging approach to develop a snow depth index (SDI). By capturing the observed spatial variability in snow depth, the SDI is a more reliable predictor than elevation and is used to adjust each year of measurements consistently despite variability in sampling spatial density. The SDI also resolves the spatial structure of summer balance better than elevation. Co-kriging is used again to spatially interpolate a derived mean summer balance index using SDI as a co-variate, which yields a spatial predictor for summer balance. A similar approach is also used to create a predictor for annual balance, which allows us to revisit years where summer balance was not obtained. The average glacier-wide surface winter, summer and annual mass balances over the period 2005-2015 are 2484, -2586, and -102 mm w.e., respectively, with changes in summer balance explaining most of the variability in annual balance. On the whole, there is good agreement between our ELA and AAR values and those derived from the end-of-summer snowline (EOSS) program, though discrepancies in some years cannot be fully accounted for. A mass balance map of Brewster Glacier in an equilibrium state, which by definition has a glacier-wide mass balance equal to zero (a balanced-budget), is used to calculate values of ELA (1923 ±25 m) and AAR (0.40) representative of the observational period. The relationships between mass balance and ELA/AAR are explored, demonstrating they are mostly linear. On average, the mass balance gradients are found to be equal to 14.5 and 7.4 mm we m-1 in the ablation and accumulation zones, respectively. However, there is considerable variability in the gradients from year to year, as well as variability between different elevation bands. The largest variability in the mass balance gradient is observed in the ablation zone.

Temporal fluctuations and frontal area change of Bangni and Dunagiri glaciers from 1962 to 2013, Dhauliganga Basin, central Himalaya, India

NASA Astrophysics Data System (ADS)

Kumar, Vinit; Mehta, Manish; Mishra, Ajai; Trivedi, Anjali

2017-05-01

Glaciers have been receding for the last 100 years in many glaciated regions of the world, and the rate of recession has accelerated during the last 60 years. Recent assessments of changes in glaciers in the Himalaya have usually recognized their variable rate of recession. The present study deals with snout retreat, frontal area vacation, and estimation of the equilibrium line altitude (ELA) of Bangni and Dunagiri glaciers, in the Dhauliganga Basin, central Himalaya (India), using multi-image satellite data (Landsat MSS, 1976; Landsat TM, 1990; Landsat ETM +, 2005) and Survey of India topographic maps (1962; 1:50,000) along with field surveys (2012 to 2014) for the period of 1962-2013. The meteorological data of the India Meteorological Department (IMD) and TRMM suggested that the central Himalaya received less precipitation between 1960 and 1990. Because of the less precipitation, glaciers receded rapidly during this period. The present study shows that Bangni and Dunagiri glaciers retreated 2080 ± 162 m and 484 ± 38 m with average rates of 41 ± 3.2 m a- 1 and 9 ± 0.6 m a- 1 between 1962 and 2013, respectively. During this period Bangni and Dunagiri glaciers lost about 17% and 11% of their length, respectively. The result also suggested that Bangni Glacier vacated 598,948 ± 12,257 m2 frontal area, while Dunagiri Glacier vacated 170,428 ± 7833 m2 frontal area between 1962 and 2013. Moreover, the estimated ELA change for Bangni Glacier was 64 ± 30 m upward during the study period. The Geological Survey of India (GSI, 1998a,b) suggested that the ELA of Dunagiri Glacier rose 28 m between 1984 and 1992 and that the glacier lost (-)16 × 106 m3 w.e. ice with an average rate of loss of (-)1.04 m w.e. a- 1. The geomorphology of the Dunagiri Valley reflected that Bangni and Dunagiri glaciers were joined together in the past. Nevertheless, these two glaciers retreat at different rates, indicating that climate change is not the only factor in glacier retreat but that geometry (size, shape, slope, and orientation) of the glacier and basin topography also plays a major role.

Balancing Rights: Education Law in a Brave New World. Papers [of the] Education Law Association (ELA) Annual Conference (48th, New Orleans, LA, November 14-16, 2002).

ERIC Educational Resources Information Center

Education Law Association, Dayton, OH.

This collection contains 54 papers from the 48th annual conference of the Education Law Association held in November 2002. It has as its focus education law, yet it covers a wide variety of topics and issues affecting the entire range of education from preschool to college. Among the topics are the following: school vouchers; school safety and…

NPS Solar Cell Array Tester Cubesat Flight Testing and Integration

DTIC Science & Technology

2014-09-01

with current (I). P V I      (2.1) This is significant because the battery discharge test will not lineup perfectly with Figure 12...accordance with the charging procedures [13]. 3. NPS-SCAT Power Budget A power budget analysis was performed to determine if the NPS-SCAT is self...using procedures developed by Marissa Brummitt, and with the assistance of Adam Hill, NPS-SCAT Program Manager. 1. ELaNa IV Random Vibration Levels

Final Environmental Impact Statement Relating to the Operation and Maintenance of the Fox River, Wisconsin Navigation Project.

DTIC Science & Technology

1977-05-01

Department of Biology University of Wisconsin-Oshkosh Johnathon P. Ela Oshkosh, Wisconsin 54901 Sierra Club, Midwest Office 444 West Main, Rm 10 Water... Indiana and more distant are,a. Access points are fairly well distributed around the various lakes and pools and provide convenient access points for...Illinois and Indiana . Although U. S. Coast Guard statistics are not available for recreational boating accidents on Lake Winnebago, it is presumed that

PARCC Accessibility Features and Accommodations Manual: Guidance for Districts and Decision-Making Teams to Ensure That PARCC Summative Assessments Produce Valid Results for All Students. Fifth Edition

ERIC Educational Resources Information Center

Bowman, Trinell; Wiener, Daniel; Branson, Danielle

2016-01-01

The Partnership for Assessment of Readiness for College and Careers (PARCC) is a group of states working together to develop a set of assessments that measure whether students are on track to be successful in college and their careers. These high-quality, computer-based K-12 assessments in mathematics and English language arts/literacy (ELA/L)…

West Europe Report

DTIC Science & Technology

1987-02-09

it is not only the many "messages" to Washington’s political figures— active or inactive—by the Greek opposition that brought about a negative...34Outside, we are doing well," or at least better, since he remains the most popular among the active political leaders, on an equal ranking in first...who stated that he had no evidence of terrorist activities by Krystallis; That of EL.AS. Major General Stelios Tzanakis, who testified that he had no

Quality Evaluation of the Traditional Medicine Majun Mupakhi ELA via Chromatographic Fingerprinting Coupled with UHPLC-DAD-Quadrupole-Orbitrap-MS and the Antioxidant Activity In Vitro

PubMed Central

Reheman, Ayinuer; Ma, Qing Ling; Nijat, Dilaram; Abdulla, Rahima

2018-01-01

By merging a high-performance liquid chromatography diode array detector (HPLC-DAD) method with high-performance thin-layer chromatography (HPTLC), an assay was developed for chemical fingerprinting and quantitative analysis of traditional medicine Majun Mupakhi ELA (MME), and constituent compounds were identified using HPLC coupled with UHPLC-DAD-Quadrupole-Orbitrap-MS method. In addition, the antioxidant capacity of MME was assessed based on the ability of components to scavenge radicals using in vitro method. Using a HPLC-DAD method with HPTLC easily validated the chemical fingerprinting results and quantified three characteristic components, namely, gallic acid (1), daidzein (2), and icariin (3), in commercial MMEs. The three compounds presented excellent regression values (R2 = 0.9999) in the ranges of the test and the method recovery was in the range from 100.49% to 100.68%. The fingerprints had 27 common characteristic peaks, of which 13 were verified by rapid UHPLC-DAD-Q-Orbitrap-MS analysis. In vitro antioxidant assays rapidly assessed and contrasted antioxidant activity or the free radical scavenging activity of the main polyphenolic classes in MMEs, and the antioxidant capacity was mostly affected by the presence of gallic acid. Thus, this study establishes a powerful and meaningful approach for MME quality control and for assessing in vitro antioxidant activity. PMID:29692853

Quality Evaluation of the Traditional Medicine Majun Mupakhi ELA via Chromatographic Fingerprinting Coupled with UHPLC-DAD-Quadrupole-Orbitrap-MS and the Antioxidant Activity In Vitro.

PubMed

Reheman, Ayinuer; Aisa, Haji Akber; Ma, Qing Ling; Nijat, Dilaram; Abdulla, Rahima

2018-01-01

By merging a high-performance liquid chromatography diode array detector (HPLC-DAD) method with high-performance thin-layer chromatography (HPTLC), an assay was developed for chemical fingerprinting and quantitative analysis of traditional medicine Majun Mupakhi ELA (MME), and constituent compounds were identified using HPLC coupled with UHPLC-DAD-Quadrupole-Orbitrap-MS method. In addition, the antioxidant capacity of MME was assessed based on the ability of components to scavenge radicals using in vitro method. Using a HPLC-DAD method with HPTLC easily validated the chemical fingerprinting results and quantified three characteristic components, namely, gallic acid (1), daidzein (2), and icariin (3), in commercial MMEs. The three compounds presented excellent regression values ( R 2 = 0.9999) in the ranges of the test and the method recovery was in the range from 100.49% to 100.68%. The fingerprints had 27 common characteristic peaks, of which 13 were verified by rapid UHPLC-DAD-Q-Orbitrap-MS analysis. In vitro antioxidant assays rapidly assessed and contrasted antioxidant activity or the free radical scavenging activity of the main polyphenolic classes in MMEs, and the antioxidant capacity was mostly affected by the presence of gallic acid. Thus, this study establishes a powerful and meaningful approach for MME quality control and for assessing in vitro antioxidant activity.

From the valley floor to the peaks: Stratigraphy and landscape evolution of the Alpine Lateglacial in the Kitzbühel Alps (Tyrol, Austria)

NASA Astrophysics Data System (ADS)

Dippenaar, Elijah; Reitner, Jürgen

2017-04-01

Our understanding of Alpine landscape evolution and more specifically, chronology of glacier activity during the Alpine Lateglacial (ALG; c. 19 - 11.7 ka) i.e. the timespan between the Würmian Pleniglacial (= Alpine Last Glacial Maximum; AlpLGM) and the beginning of the Holocene, is based on the evidence of only few areas in the Alps. In order to get a better understanding of glaciation and palaeoclimate during this phase, N-S and E-W transects are needed. The Kitzbühel Alps, which are currently not glaciated, span an area of 1700km2 and have peaks that reach c. 2400m a.s.l. They lie at the center of the Eastern Alps on the northern rim, which is more humid than the relatively dry central parts. A modern geological investigation of the ALG record is missing in the Kitzbühel Alps. In order to overcome this gap of knowledge and to gain a more complete understanding of the ALG landscape development, a pioneering study has been performed in the area of Langer Grund Valley, a tributary valley of the Kelchsau Valley. This was done through detailed field mapping, thereby describing the shape and sediment composition of Quaternary morphological features, such as moraines, landslides and rock glacier deposits. Sedimentary evidence of one short glacial advance and two glacial stadials were identified. In chronological order they were named the: Frommbach advance, the Arnbach (glacier) halt and the Küharn halt. Where possible, palaeoglaciers were constructed using ArcGIS. With the palaeoglaciers, equlibrium line altitudes (ELA) were calculated and compared to ELA values of known glacial stadials in an attempt to correlate the relative local stratigraphy to the Lateglacial stratigraphy. Four methods to calculate ELAs were used; Maximum Elevation of Lateral Moraines (MELM), Toe to Headwall Altitude Ratio (THAR), Area x Altitude (AA) and Accumulation Area Ratio (AAR). Furthermore, the glacial sedimentary sequence of the study area was compared to that of the Gschnitz Valley (following the approach of Reitner et al. 2016). The result of which was that the glacial sedimentary sequences were very similar. Through the comparison of ELAs and sedimentary sequences, the Frommbach advance is correlated to the Phase of Ice-decay. Compared to the data of Reitner (2007) the Frommbach advance represents a second glacier advance in the Kelchsau Valley within this short-lasting phase around 19 ka. The Arnbach halt represents most likely the Gschnitz stadial (16-17 ka). The Küharn halt is correlated to the Younger Dryas-aged Egesen stadial (Younger Dryas; 12.8-11.7 ka). In addition, the relative timing of the activity of (nowadays relict) rock glaciers and of the onset of deep-seated gravitational slope deformations (DSGSDs) could be constrained based on the overlap of those features with the reconstructed glacial record. References: Reitner J.M., 2007: Glacial dynamics at the beginning of Termination I in the Eastern Alps and their stratigraphic implications. Quaternary International 164-165: 64-84. Reitner, J.M., Ivy-Ochs, S., Drescher-Schneider, R., Hajdas, I., Linner, M., 2016: Reconsidering the current stratigraphy of the Alpine Lateglacial: Implications of the sedimentary and morphological record of the Lienz area (Tyrol/Austria). E&G Quaternary Science Journal 65: 113-144.

Glaciation of alpine valleys: The glacier - debris-covered glacier - rock glacier continuum

NASA Astrophysics Data System (ADS)

Anderson, Robert S.; Anderson, Leif S.; Armstrong, William H.; Rossi, Matthew W.; Crump, Sarah E.

2018-06-01

Alpine ice varies from pure ice glaciers to partially debris-covered glaciers to rock glaciers, as defined by the degree of debris cover. In many low- to mid-latitude mountain ranges, the few bare ice glaciers that do exist in the present climate are small and are found where snow is focused by avalanches and where direct exposure to radiation is minimized. Instead, valley heads are more likely to be populated by rock glaciers, which can number in the hundreds. These rock-cloaked glaciers represent some of the most identifiable components of the cryosphere today in low- to mid-latitude settings, and the over-steepened snouts pose an often overlooked hazard to travel in alpine terrain. Geomorphically, rock glaciers serve as conveyor belts atop which rock is pulled away from the base of cliffs. In this work, we show how rock glaciers can be treated as an end-member case that is captured in numerical models of glaciers that include ice dynamics, debris dynamics, and the feedbacks between them. Specifically, we focus on the transition from debris-covered glaciers, where the modern equilibrium line altitude (ELA) intersects the topography, to rock glaciers, where the modern ELA lies above the topography. On debris-covered glaciers (i.e., glaciers with a partial rock mantle), rock delivered to the glacier from its headwall, or from sidewall debris swept into the glacier at tributary junctions, travels englacially to emerge below the ELA. There it accumulates on the surface and damps the rate of melt of underlying ice. This allows the termini of debris-covered glaciers to extend beyond debris-free counterparts, thereby decreasing the ratio of accumulation area to total area of the glacier (AAR). In contrast, rock glaciers (i.e., glaciers with a full rock mantle) occur where and when the environmental ELA rises above the topography. They require avalanches and rockfall from steep headwalls. The occurrence of rock glaciers reflects this dependence on avalanche sources because they are most common on lee sides of ridges and peaks where wind-blown snow enhances the strength of the avalanche source. To maintain positive mass balance, the avalanche cone developed in the winter must be sufficiently thick not to melt entirely in the summer, thus providing an ice accumulation area for the rock glacier. In the absence of rockfall, this would support a short cirque glacier. The presence of debris, however, facilitates the development of rock glaciers with lengths of hundreds of meters, thicknesses of tens of meters, and speeds of meters per year that are well described by numerical models. Numerical models are used to explore the alpine glacier response to its climate history. In warming climates, a debris-covered glacier can transform into a much shorter rock glacier, leaving in its wake a thinning ice-cored moraine. Rock glaciers will persist in landscapes well beyond debris-free counterparts because they have much longer response times to climate change. The headwaters of alpine basins with steep headwalls will therefore oscillate between glacier and rock glacier occupation over glacial-interglacial cycles, maintaining a means by which rock from the headwall can be conveyed away. This enhances the asymmetry of alpine ridgelines, with downwind valleys biting deeply into the range crests, as originally noted by G.K. Gilbert.

Energy balance-based distributed modeling of snow and glacier melt runoff for the Hunza river basin in the Pakistan Karakoram Himalayan region

NASA Astrophysics Data System (ADS)

Shrestha, M.; Wang, L.; Koike, T.; Xue, Y.; Hirabayashi, Y.; Ahmad, S.

2012-12-01

A spatially distributed biosphere hydrological model with energy balance-based multilayer snow physics and multilayer glacier model, including debris free and debris covered surface (enhanced WEB-DHM-S) has been developed and applied to the Hunza river basin in the Pakistan Karakoram Himalayan region, where about 34% of the basin area is covered by glaciers. The spatial distribution of seasonal snow and glacier cover, snow and glacier melt runoff along with rainfall-contributed runoff, and glacier mass balances are simulated. The simulations are carried out at hourly time steps and at 1-km spatial resolution for the two hydrological years (2002-2003) with the use of APHRODITE precipitation dataset, observed temperature, and other atmospheric forcing variables from the Global Land Data Assimilation System (GLDAS). The pixel-to-pixel comparisons for the snow-free and snow-covered grids over the region reveal that the simulation agrees well with the Moderate Resolution Imaging Spectroradiometer (MODIS) eight-day maximum snow-cover extent data (MOD10A2) with an accuracy of 83% and a positive bias of 2.8 %. The quantitative evaluation also shows that the model is able to reproduce the river discharge satisfactorily with Nash efficiency of 0.92. It is found that the contribution of rainfall to total streamflow is small (about 10-12%) while the contribution of snow and glacier is considerably large (35-40% for snowmelt and 50-53% for glaciermelt, respectively). The model simulates the state of snow and glaciers at each model grid prognostically and thus can estimate the net annual mass balance. The net mass balance varies from -2 m to +2 m water equivalent. Additionally, the hypsography analysis for the equilibrium line altitude (ELA) suggests that the average ELA in this region is about 5700 m with substantial variation from glacier to glacier and region to region. This study is the first to adopt a distributed biosphere hydrological model with the energy balance- based multilayer snow and glacier module to estimate the spatial distribution of snow/glacier cover and snow and glacier melt runoff for a river basin in the Karakoram Himalayan region.

Automating the implementation of an equilibrium profile model for glacier reconstruction in a GIS environment

NASA Astrophysics Data System (ADS)

Frew, Craig R.; Pellitero, Ramón; Rea, Brice R.; Spagnolo, Matteo; Bakke, Jostein; Hughes, Philip D.; Ivy-Ochs, Susan; Lukas, Sven; Renssen, Hans; Ribolini, Adriano

2014-05-01

Reconstruction of glacier equilibrium line altitudes (ELAs) associated with advance stages of former ice masses is widely used as a tool for palaeoclimatic reconstruction. This requires an accurate reconstruction of palaeo-glacier surface hypsometry, based on mapping of available ice-marginal landform evidence. Classically, the approach used to define ice-surface elevations, using such evidence, follows the 'cartographic method', whereby contours are estimated based on an 'understanding' of the typical surface form of contemporary ice masses. This method introduces inherent uncertainties in the palaeoclimatic interpretation of reconstructed ELAs, especially where the upper limits of glaciation are less well constrained and/or the age of such features in relation to terminal moraine sequences is unknown. An alternative approach is to use equilibrium profile models to define ice surface elevations. Such models are tuned, generally using basal shear stress, in order to generate an ice surface that reaches 'target elevations' defined by geomorphology. In areas where there are no geomorphological constraints for the former ice surface, the reconstruction is undertaken using glaciologiaclly representative values for basal shear stress. Numerical reconstructions have been shown to produce glaciologically "realistic" ice surface geometries, allowing for more objective and robust comparative studies at local to regional scales. User-friendly tools for the calculation of equilibrium profiles are presently available in the literature. Despite this, their use is not yet widespread, perhaps owing to the difficult and time consuming nature of acquiring the necessary inputs from contour maps or digital elevation models. Here we describe a tool for automatically reconstructing palaeo-glacier surface geometry using an equilibrium profile equation implemented in ArcGIS. The only necessary inputs for this tool are 1) a suitable digital elevation model and 2) mapped outlines of the former glacier terminus position (usually a frontal moraine system) and any relevant geomorphological constraints on ice surface elevation (e.g. lateral moraines, trimlines etc.). This provides a standardised method for glacier reconstruction that can be applied rapidly and systematically to large geomorphological datasets.

A Review of Models of the Fluidic Generator.

DTIC Science & Technology

1980-11-01

ATTN l)ELA SAS-T INI. R ’ C’S N VANRIF ’ PORN )LC.iS C ENTER W HITE SANDS MISSILE RANGE, NIM HOS02 mMANDICE 1.PA IFD)LOS’ 1CS ARPMY "SH " STO G CPOR...ENiINEERIN’, TECHNICAL REP RTS, ATT’I F. HOWARD F. ’-. BOY I CARNEGIE-MELLON UNIVERSITY R’ 10-408 ’AE RIDGE, TN 37H3D SCRENIEY PARK ATTN DAVID WORMLEY, MECH

Guide to Simulation Scheduling. Appendices B and C,

DTIC Science & Technology

1986-01-01

2v502) lEARN ,ElA7L CAL03120 YEAkN=YEAKN4I CAL03130 610 COKT14UE CALO-1140 C 502 FOkt T IX/,1XYLAR m lo g 93113 ol2 i X, MCI 1H= 19 2 o1 X 3113) CAL0315,O...1791777#END=777) NRAND MICCO650 GC 10l 778 MIC00660 * 777 WR17E(6,0) I PLEASE ENTER A NUMBER FO FANDOM NUMBER CEIEkATION’ M1C00670 REAC(59*) NRAND

ANMCO/ELAS/SIBioC Consensus Document: biomarkers in heart failure

PubMed Central

Gulizia, Michele Massimo; Clerico, Aldo; Di Tano, Giuseppe; Emdin, Michele; Feola, Mauro; Iacoviello, Massimo; Latini, Roberto; Mortara, Andrea; Valle, Roberto; Misuraca, Gianfranco; Passino, Claudio; Masson, Serge; Aimo, Alberto; Ciaccio, Marcello; Migliardi, Marco

2017-01-01

Abstract Biomarkers have dramatically impacted the way heart failure (HF) patients are evaluated and managed. A biomarker is a characteristic that is objectively measured and evaluated as an indicator of normal biological or pathogenic processes, or pharmacological responses to a therapeutic intervention. Natriuretic peptides [B-type natriuretic peptide (BNP) and N-terminal proBNP] are the gold standard biomarkers in determining the diagnosis and prognosis of HF, and a natriuretic peptide-guided HF management looks promising. In the last few years, an array of additional biomarkers has emerged, each reflecting different pathophysiological processes in the development and progression of HF: myocardial insult, inflammation, fibrosis, and remodelling, but their role in the clinical care of the patient is still partially defined and more studies are needed before to be well validated. Moreover, several new biomarkers have the potential to identify patients with early renal dysfunction and appear to have promise to help the management cardio-renal syndrome. With different biomarkers reflecting HF presence, the various pathways involved in its progression, as well as identifying unique treatment options for HF management, a closer cardiologist-laboratory link, with a multi-biomarker approach to the HF patient, is not far ahead, allowing the unique opportunity for specifically tailoring care to the individual pathological phenotype. PMID:28751838

ELAS: A general-purpose computer program for the equilibrium problems of linear structures. Volume 2: Documentation of the program. [subroutines and flow charts

NASA Technical Reports Server (NTRS)

Utku, S.

1969-01-01

A general purpose digital computer program for the in-core solution of linear equilibrium problems of structural mechanics is documented. The program requires minimum input for the description of the problem. The solution is obtained by means of the displacement method and the finite element technique. Almost any geometry and structure may be handled because of the availability of linear, triangular, quadrilateral, tetrahedral, hexahedral, conical, triangular torus, and quadrilateral torus elements. The assumption of piecewise linear deflection distribution insures monotonic convergence of the deflections from the stiffer side with decreasing mesh size. The stresses are provided by the best-fit strain tensors in the least squares at the mesh points where the deflections are given. The selection of local coordinate systems whenever necessary is automatic. The core memory is used by means of dynamic memory allocation, an optional mesh-point relabelling scheme and imposition of the boundary conditions during the assembly time.

KSC-2010-5777

NASA Image and Video Library

2010-11-16

San Luis Obispo, Calif. -- 101116-F-8290C-045 -- Students at California Polytechnic State University Cal Poly prepare to integrate miniature research satellites called CubeSats into a Poly Picosatellite Orbital Deployer PPOD container. The PPOD and CubeSat Project were developed by Cal Poly and Stanford University’s Space Systems Development Lab for use on NASA’s Educational Launch of Nanosatellite ELaNa missions. Each CubeSat measures about 4-inches cubed and is about the same volume as a quart. The CubeSats weigh about 2.2 pounds, must conform to standard aerospace materials and must operate without propulsion. The satellites are being prepared to launch with NASA's Glory spacecraft aboard an Orbital Sciences Corp. Taurus XL rocket, targeted to lift off Feb. 23, 2011, from Vandenberg's Space Launch Complex 576-E. Glory is scheduled to collect data on the properties of aerosols and black carbon from its place in low Earth orbit. It also will help scientists understand how the sun's irradiance affects Earth's climate. Photo credit: U.S. Air Force/Jerry E. Clemens Jr.

Rates of Deglaciation during the Last Glaciation and Holocene in the Cordillera Vilcanota-Quelccaya Ice Cap Region, Southeastern Perú

NASA Astrophysics Data System (ADS)

Mark, Bryan G.; Seltzer, Geoffrey O.; Rodbell, Donald T.; Goodman, Adam Y.

2002-05-01

Moraine chronology is combined with digital topography to model deglacial rates of paleoglacier volumes in both the Huancané Valley on the west side of the Quelccaya Ice Cap and the Upismayo Valley on the northwest side of the Cordillera Vilcanota. The fastest rates of deglaciation (39×10 -5 to 114×10 -5 km 3 yr -1 and 112×10 -5 to 247×10 -5 km 3 yr -1 for each valley, respectively) were calculated for the most recent paleoglaciers, corresponding to the last few centuries. These results are consistent with observations in the Venezuelan Andes showing high rates of deglaciation since the Little Ice Age. These rates also fall within the range of 20th century rates of deglaciation measured on the Quelccaya Ice Cap (29×10 -5 to 220×10 -5 km 3 yr -1, Brecher and Thompson, 1993; Thompson, 2000). These results imply that rates of deglaciation may fluctuate significantly over time and that high rates of deglaciation may not be exclusive to the late 20th century. Equilibrium line altitude (ELA) depressions for the ice volumes of the last glaciation modeled here were computed as 230 m for the Quelccaya Ice Cap and 170 m for the Cordillera Vilcanota. Maximum ELA depressions are lower than previously published: <500 m for the Cordillera Vilcanota and <400 m for the Quelccaya Ice Cap. These lower values could imply a topographic control over paleoglacier extent.

Homozygous HAX1 mutations in severe congenital neutropenia patients with sporadic disease: a novel mutation in two unrelated British kindreds.

PubMed

Smith, Bradley N; Ancliff, Phil J; Pizzey, Arnold; Khwaja, Asim; Linch, David C; Gale, Rosemary E

2009-03-01

Patients with autosomal dominant (AD), sporadic and X-linked severe congenital neutropenia (SCN) may have mutations in the elastase 2 (ELA2) or Wiskott-Aldrich syndrome (WAS) genes. Homozygous mutations in the HAX1 gene have recently been reported in autosomal recessive (AR) cases of primarily Middle-Eastern descent and the original Kostmann family. We screened 109 predominantly Caucasian SCN kindreds for mutations in these genes; 33 (30%) had 24 different ELA2 mutations, five of them novel, two kindreds (2%) had WAS mutations and four kindreds (4%) had three different HAX1 mutations, two of them novel. One HAX1 mutation (p.Ser43LeufsX11) was found in an AR Ashkenazi Jewish kindred, the other (p.Glu31LysfsX54) in two unrelated British patients with sporadic disease. Microsatellite analysis of the HAX1 locus revealed a common haplotype (maximum distance 4.1 Megabases) for the p.Glu31LysfsX54 patients, suggesting a possible ancestral founder. In functional assays, the level of spontaneous and staurosporine-induced apoptosis was increased in neutrophils from both p.Ser43LeufsX11 patients but not a p.Glu31LysfsX54 patient, suggesting the possible presence of modifying factors. The low incidence of HAX1 mutations in our study suggests that the frequency may vary between racial groups but suggests that irrespective of inheritance or racial origin, SCN patients should be screened for HAX1 mutations.

Fostering Ecological Literacy: A Case Study of the Saint John Harbour in Two High School English Language Arts Classrooms

NASA Astrophysics Data System (ADS)

Douglas, Velta

Integrating environmental education into curriculum in a way that tackles the holistic and complicated nature of multi-dimensional issues continues to be a challenge for educators and administrators. There is potential in using ecological literacy to introduce local environmental case studies into English Language Arts high school classrooms. This research examines the experiences of two ELA classrooms in one Saint John, NB, high school with a two-week unit based on stakeholder relationships within the Saint John Harbour. Through presentations by guest speakers and research sourced from local community groups, students learned about the highly complex environmental issues that inform management decisions for the Harbour. Using these materials as background, students participated in a mock stakeholders meeting. Case study methodology was used to explore student learning in both a higher-level and a lower-level grade 10 ELA class. Data for the analysis included: cognitive mapping exercises; oral and written classroom assignments and activities; a videotape of the mock stakeholder meetings; a focus group interview with selected students; and researcher field notes. Data demonstrated significant student learning about environmental issues including increased sophistication in describing links between and among environmental issues affecting the harbour, and much more complex understandings of the positions and roles of the various stakeholder groups. Some important areas of resistance to new learning were also evident. Implications for practice and policy and recommendations for future research are discussed.

DNA methylation differences at the glucocorticoid receptor gene in depression are related to functional alterations in hypothalamic-pituitary-adrenal axis activity and to early life emotional abuse.

PubMed

Farrell, Chloё; Doolin, Kelly; O' Leary, Niamh; Jairaj, Chaitra; Roddy, Darren; Tozzi, Leonardo; Morris, Derek; Harkin, Andrew; Frodl, Thomas; Nemoda, Zsófia; Szyf, Moshe; Booij, Linda; O'Keane, Veronica

2018-07-01

Depression is associated with alterations in hypothalamic-pituitary-adrenal (HPA) axis activity. A proposed mechanism to explain these alterations are changes in DNA methylation levels, secondary to early life adversity (ELA), at stress-related genes. Two gene regions that have been implicated in the literature, the glucocorticoid receptor gene (NR3C1) exon 1F and the FKBP5 gene intron 7 were examined in 67 individuals (33 depressed patients and 34 controls). We investigated whether cortisol concentrations, evaluated in 25 depressed patients and 20 controls, and measures of ELA were associated with the degree of methylation at these candidate gene regions. Mean NR3C1 exon 1F DNA methylation levels were significantly increased in the depressed cohort and the degree of methylation was found to be positively associated with morning cortisol concentrations. DNA methylation levels at specific CG sites within the NR3C1 exon 1F were related to childhood emotional abuse severity. DNA methylation at CG38 was related to both HPA axis and childhood emotional abuse measures in the depressed group. No FKBP5 differences were revealed. Our findings suggest that hypermethylation at the NR3C1 exon 1F may occur in depression. This locus-specific epigenetic change is associated with higher basal HPA axis activity, possibly reflecting acquired glucocorticoid receptor resistance. Crown Copyright © 2018. Published by Elsevier B.V. All rights reserved.

Determination of the utility of remote sensing data for land use/cover analysis in the lower Appalachia region: Assessing the utility of remote sensing data for archeological site recognition

NASA Technical Reports Server (NTRS)

Weber, N. V.

1983-01-01

Thematic Mapper Simulator (TMS) data were gathered by NASA/ERL over a portion of the lower Ohio River and the middle Mississippi River valleys on April 11, 1982. CIR imagery accompanied the 10 and 30 meter resolution TMS data sets. This area is somewhat unique archeologically as there exists a concentration of sites with major features such as mounds, earthworks, and villages. It was the primary purpose of this study to determine the utility of TMS data in identifying signatures which are distinctly archeological. TMS data were processed using the NASA/ERL software package ELAS. No signatures that were distinctly archeological were detected, due in large part to the complexity of the land cover and land use practices. However, as more sophisticated classification techniques were employed, the classes which were related to archeological features were narrowed. TMS data could certainly be of assistance to a trained archeologist/interpreter in narrowing an area which has to be field-surveyed as anomalous features can be recognized within a particular environmental context.

Last Glacial Maximum and Lateglacial in the Polish High Tatra Mountains - Revised deglaciation chronology based on the 10Be exposure age dating

NASA Astrophysics Data System (ADS)

Makos, Michał; Rinterknecht, Vincent; Braucher, Régis; Tołoczko-Pasek, Anna; Arnold, Maurice; Aumaître, Georges; Bourlès, Didier; Keddadouche, Karim; Aster Team

2018-05-01

Deglaciation chronology of the Polish High Tatra Mountains has been reconstructed based on 10Be exposure age dating. Fifty-seven rock samples were collected from boulders located on the terminal and lateral moraines that limit the horizontal extent of the LGM and the Lateglacial glaciers in the Biała Woda and Sucha Woda catchments. The uncertainty-weighted mean age of 21.5 ± 2.5 ka obtained for the maximum terminal moraine in the Sucha Woda Valley indicates that the oldest preserved moraines were formed during the global LGM. The age population ranges between 15.1 ± 1.0 and 28.3 ± 2.0 ka, and suggests that glaciers reached their maximum position (LGM I) as early as 28-25 ka and the final stabilization of the form occurred much later possibly after melting of buried dead ice. The younger glacial oscillation (LGM II) occurred no later than 20.5 ka and is represented by well-preserved termino-lateral moraine systems in the Pańszczyca Valley. The first Lateglacial stage (LG1) in the study area is documented in the Rybi Potok Valley at the RP1 moraine (1300 m a.s.l.), which was stable at around 16.6 ± 0.3 ka. The younger LG2 stage has no defined absolute age, however, it is constrained between 16.5 and 15.5 ka by the timing of the LG3 stage. This cold event is represented by well-formed moraines in the Roztoka/Pięć Stawów Polskich, Rybi Potok and Pańszczyca valleys of which exposure age indicates their deposition between 15.0 ± 0.5 and 15.6 ± 0.1 ka. The LG1, LG2 and LG3 stages likely occurred during the Oldest Dryas cold stage (Greenland Stadial 2.1a) related to the North Atlantic cooling Heinrich Event 1. The youngest glacial oscillation is evidenced by moraines in the Pusta and Pańszczyca valleys. These moraines are composed of very large granitic blocks of which exposure ages often exhibit isotope inheritance. This is reflected by the youngest P3 moraine in the Pańszczyca Valley with a mean age of deposition close to the LGM. The R4 moraine system in the Pusta Valley, however, indicates two oscillations phases that occurred at around 13 ka and correlates well with the timing of RP5 moraine formation in the Za Mnichem Valley. The LG4 stage is related to the climate cooling during the Younger Dryas (Greenland Stadial 1). LGM ELAs reconstructed for the Biała Woda and Sucha Woda/Pańszczyca glaciers were located at 1460-1480 m a.s.l. During the Oldest Dryas stages, the ELA in the High Tatras rose from 1600 to 1650 m a.s.l. in the Rybi Potok Valley and from 1700 to 1800 m a.s.l. in the Roztoka/Pięć Stawów Polskich Valley. The Younger Dryas ELA, depending on glacier's exposition, was located between 1950 and 2000 m a.s.l. Climate modelling results show that the LGM glaciers (maximum advance) could have advanced in the High Tatras when the mean annual temperature was lower than today by 11-12 °C and precipitation was reduced by 40-60%. During the Lateglacial stages the temperature decrease in the study area changed from 10 °C during the Oldest Dryas to 6 °C during the Younger Dryas and precipitation lowering decreased from -50% to -30% or even -10%, respectively compare to modern conditions.

Visual attitude propagation for small satellites

NASA Astrophysics Data System (ADS)

Rawashdeh, Samir A.

As electronics become smaller and more capable, it has become possible to conduct meaningful and sophisticated satellite missions in a small form factor. However, the capability of small satellites and the range of possible applications are limited by the capabilities of several technologies, including attitude determination and control systems. This dissertation evaluates the use of image-based visual attitude propagation as a compliment or alternative to other attitude determination technologies that are suitable for miniature satellites. The concept lies in using miniature cameras to track image features across frames and extracting the underlying rotation. The problem of visual attitude propagation as a small satellite attitude determination system is addressed from several aspects: related work, algorithm design, hardware and performance evaluation, possible applications, and on-orbit experimentation. These areas of consideration reflect the organization of this dissertation. A "stellar gyroscope" is developed, which is a visual star-based attitude propagator that uses relative motion of stars in an imager's field of view to infer the attitude changes. The device generates spacecraft relative attitude estimates in three degrees of freedom. Algorithms to perform the star detection, correspondence, and attitude propagation are presented. The Random Sample Consensus (RANSAC) approach is applied to the correspondence problem to successfully pair stars across frames while mitigating falsepositive and false-negative star detections. This approach provides tolerance to the noise levels expected in using miniature optics and no baffling, and the noise caused by radiation dose on orbit. The hardware design and algorithms are validated using test images of the night sky. The application of the stellar gyroscope as part of a CubeSat attitude determination and control system is described. The stellar gyroscope is used to augment a MEMS gyroscope attitude propagation algorithm to minimize drift in the absence of an absolute attitude sensor. The stellar gyroscope is a technology demonstration experiment on KySat-2, a 1-Unit CubeSat being developed in Kentucky that is in line to launch with the NASA ELaNa CubeSat Launch Initiative. It has also been adopted by industry as a sensor for CubeSat Attitude Determination and Control Systems (ADCS). KEYWORDS: Small Satellites, Attitude Determination, Egomotion Estimation, RANSAC, Image Processing.

Third International Kharkov Symposium "Physics and Engineering of Millimeter and Submillimeter Waves" MSMW󈨦 Symposium Proceedings, Volume 1,

DTIC Science & Technology

1998-09-01

potential of the surface wave electromagnetic field; ea is the unit of the polarization vectors : ex = ela. = e2x= (qx/\\q\\)\\/L\\q\\/(ei + e0), ely... polarization basis of the incident wave: EB°=eB^(/kr), (1) where e„ is the cyclic unit vector , n = ±1, k is the wave vector . The equation describing...rectangular grid. From the direction determined by wave vector k0, the plane electromagnetic wave of linear polarization incidents onto the array. It

Space Situational Awareness of Large Numbers of Payloads from a Single Deployment

DTIC Science & Technology

2014-09-01

challenges [12]. 3. CHIPSAT CLOUD DEPLOYMENT AND CATALOGING One of the six satellites deployed as part of the April 18, 2014, Falcon 9 launch to the ISS was...Cloud Modeling Techniques,” Journal of Spacecraft and Rockets , Vol. 33, No. 4, 550–555, 1996. 2. Swinerd, G.G., Barrows, S.P., and Crowther, R., “Short... Big Sky, Montana, 2013. 11. Voss, H.D., Dailey, J.F., Crowley, J.C., et al., “TSAT Globalstar ELaNa-5 Extremely Low-Earth Orbit (ELEO) Satellite,” 28th

STS-112 crew in front of S0 Truss Structure

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. -- In the Operations and Checkout Building, the STS-112 crew stands under the S0 Integrated Truss Structure, waiting to be transported to the launch pad for mission STS-110. From left are Mission Specialist David Wolf, Pilot Pam ela Melroy; Commander Jeffrey Ashby; and Mission Specialist Piers Sellers. Mission STS-112 will be ferrying the S1 ITS to the International Space Station on its scheduled Aug. 15 flight. The S1 truss will be attached to the S0 truss

Quaternary glaciation of the Lato Massif, Zanskar Range of the NW Himalaya

NASA Astrophysics Data System (ADS)

Orr, Elizabeth N.; Owen, Lewis A.; Saha, Sourav; Caffee, Marc W.; Murari, Madhav K.

2018-03-01

The glacial chronostratigraphy and history of the Lato Massif of Zanskar northern India is defined for the first time using geomorphic mapping and 10Be surface exposure dating. Three local glacial stages, the Lato, Shiyul and Kyambu, are dated to 244-49, 25-15 and 3.4-0.2 ka, respectively. The Lato glacial stage was the most extensive period of glaciation, characterized by expanded ice caps with glaciers advancing to ∼16 km from their present position. Large till deposits are associated with this glacial stage, which represent a time of heightened glacial erosion and localized incision, and increased rates of sediment transfer and deposition. The glacial style transitioned to entrenched valley glaciation during the Shiyul glacial stage. Hummocky moraine complexes reflecting fluctuating glacier margins characterize this glaciation. Glaciers have been confined to the cirques and headwalls of the massif during and since the Kyambu glacial stage. Equilibrium-line altitude (ELA) reconstructions help define the shifts in glaciation over time, with ELA depressions changing from 470 ± 140, 270 ± 80 to 100 ± 30 m for the Lato, Shiyul and Kyambu glacial stages, respectively. The change of glacial style during the latter part of the Quaternary is similar to other regions of the Transhimalaya and Tibet suggesting that this pattern of glaciation may reflect regional climatic forcing. The evolution of the Lato Massif from an isolated alpine plateau to a steeply incised massif over the last several glacial-interglacial cycles may have also influenced the shifts from ice cap to valley glaciation.

Dramatic mass loss in extreme high-elevation areas of a western Himalayan glacier: observations and modeling

NASA Astrophysics Data System (ADS)

Zhao, Huabiao; Yang, Wei; Yao, Tandong; Tian, Lide; Xu, Baiqing

2016-08-01

Rapid climate change at high elevations has accelerated glacier retreat in the Himalayas and Tibetan Plateau. However, due to the lack of long-term glaciological measurements, there are still uncertainties regarding when the mass loss began and what the magnitude of mass loss is at such high elevations. Based on in situ glaciological observations during the past 9 years and a temperature-index mass balance model, this study investigates recent mass loss of the Naimona’nyi Glacier in the western Himalayas and reconstructs a 41-year (1973/74-2013/14) equilibrium line altitude (ELA) and glacier-wide mass loss. The result indicates that even at 6000 m above sea level (a.s.l.), the annual mass loss reaches ~0.73 m water equivalent (w.e.) during the past 9 years. Concordant with the abrupt climate shift in the end of 1980s, the ELA has dramatically risen from ~5969 ± 73 m a.s.l. during 1973/74-1988/89 to ~6193 ± 75 m a.s.l. during 1989/90-2013/14, suggesting that future ice cores containing uninterrupted climate records could only be recovered at least above 6200 m a.s.l. in the Naimona’nyi region. The glacier-wide mass balance over the past 41 years is averaged to be approximately -0.40 ± 0.17 m w.e., exhibiting a significant increase in the decadal average from -0.01 ± 0.15 to -0.69 ± 0.21 m w.e.

Hypsometric control on glacier mass balance sensitivity in Alaska and northwest Canada

NASA Astrophysics Data System (ADS)

McGrath, D.; Sass, L.; O'Neel, S.; Arendt, A.; Kienholz, C.

2017-03-01

Glacier hypsometry provides a first-order approach for assessing a glacier's response to climate forcings. We couple the Randolph Glacier Inventory to a suite of in situ observations and climate model output to examine potential change for the ˜27,000 glaciers in Alaska and northwest Canada through the end of the 21st century. By 2100, based on Representative Concentration Pathways (RCPs) 4.5-8.5 forcings, summer temperatures are predicted to increase between +2.1 and +4.6°C, while solid precipitation (snow) is predicted to decrease by -6 to -11%, despite a +9 to +21% increase in total precipitation. Snow is predicted to undergo a pronounced decrease in the fall, shifting the start of the accumulation season back by ˜1 month. In response to these forcings, the regional equilibrium line altitude (ELA) may increase by +105 to +225 m by 2100. The mass balance sensitivity to this increase is highly variable, with the most substantive impact for glaciers with either limited elevation ranges (often small (<1 km2) glaciers, which account for 80% of glaciers in the region) or those with top-heavy geometries, like icefields. For more than 20% of glaciers, future ELAs, given RCP 6.0 forcings, will exceed the maximum elevation of the glacier, resulting in their eventual demise, while for others, accumulation area ratios will decrease by >60%. Our results highlight the first-order control of hypsometry on individual glacier response to climate change, and the variability that hypsometry introduces to a regional response to a coherent climate perturbation.

Space Environment's Effects on Seal Materials

NASA Technical Reports Server (NTRS)

deGroh, Henry C., III; Daniels, Christopher C.; Dunlap, Patrick; Miller, Sharon; Dever, Joyce; Waters, Deborah; Steinetz, Bruce M.

2007-01-01

A Low Impact Docking System (LIDS) is being developed by the NASA Johnson Space Center to support future missions of the Crew Exploration Vehicle (CEV). The LIDS is androgynous, such that each system half is identical, thus any two vehicles or modules with LIDS can be coupled. Since each system half is a replica, the main interface seals must seal against each other instead of a conventional flat metal surface. These sealing surfaces are also expected to be exposed to the space environment when vehicles are not docked. The NASA Glenn Research Center (NASA GRC) is supporting this project by developing the main interface seals for the LIDS and determining the durability of candidate seal materials in the space environment. In space, the seals will be exposed to temperatures of between 50 to 50 C, vacuum, atomic oxygen, particle and ultraviolet radiation, and micrometeoroid and orbital debris (MMOD). NASA GRC is presently engaged in determining the effects of these environments on our candidate elastomers. Since silicone rubber is the only class of seal elastomer that functions across the expected temperature range, NASA GRC is focusing on three silicone elastomers: two provided by Parker Hannifin (S0-899-50 and S0-383-70) and one from Esterline Kirkhill (ELA-SA-401). Our results from compression set, elastomer to elastomer adhesion, and seal leakage tests before and after various simulated space exposures will be presented.

On the Utilization of Ice Flow Models and Uncertainty Quantification to Interpret the Impact of Surface Radiation Budget Errors on Estimates of Greenland Ice Sheet Surface Mass Balance and Regional Estimates of Mass Balance

NASA Astrophysics Data System (ADS)

Schlegel, N.; Larour, E. Y.; Gardner, A. S.; Lang, C.; Miller, C. E.; van den Broeke, M. R.

2016-12-01

How Greenland ice flow may respond to future increases in surface runoff and to increases in the frequency of extreme melt events is unclear, as it requires detailed comprehension of Greenland surface climate and the ice sheet's sensitivity to associated uncertainties. With established uncertainty quantification tools run within the framework of Ice Sheet System Model (ISSM), we conduct decadal-scale forward modeling experiments to 1) quantify the spatial resolution needed to effectively force distinct components of the surface radiation budget, and subsequently surface mass balance (SMB), in various regions of the ice sheet and 2) determine the dynamic response of Greenland ice flow to variations in components of the net radiation budget. The Glacier Energy and Mass Balance (GEMB) software is a column surface model (1-D) that has recently been embedded as a module within ISSM. Using the ISSM-GEMB framework, we perform sensitivity analyses to determine how perturbations in various components of the surface radiation budget affect model output; these model experiments allow us predict where and on what spatial scale the ice sheet is likely to dynamically respond to changes in these parameters. Preliminary results suggest that SMB should be forced at at least a resolution of 23 km to properly capture dynamic ice response. In addition, Monte-Carlo style sampling analyses reveals that the areas with the largest uncertainty in mass flux are located near the equilibrium line altitude (ELA), upstream of major outlet glaciers in the North and West of the ice sheet. Sensitivity analysis indicates that these areas are also the most vulnerable on the ice sheet to persistent, far-field shifts in SMB, suggesting that continued warming, and upstream shift in the ELA, are likely to result in increased velocities, and consequentially SMB-induced thinning upstream of major outlet glaciers. Here, we extend our investigation to consider various components of the surface radiation budget separately, in order to determine how and where errors in these fields may independently impact ice flow. This work was performed at the California Institute of Technology's Jet Propulsion Laboratory under a contract with the National Aeronautics and Space Administration's Cryosphere and Interdisciplinary Research in Earth Science Programs.

Climatic and Tectonic Controls on Topography in the Northern Basin and Range

NASA Astrophysics Data System (ADS)

Foster, D.; Brocklehurst, S. H.; Gawthorpe, R. L.

2006-12-01

This study takes advantage of the relatively simple tectonics of the normal fault-bounded Lost River and Lemhi Ranges and the Beaverhead Mountains, eastern Idaho, USA, to assess the roles of climate, erosion, and tectonics in topographic evolution through a combination of digital topographic analyses and field observations. These ranges transect the southern limit of Quaternary glaciation, and drainage basins record a range of glacial extents and histories, allowing for comparisons between climatic and tectonic controls. At a catchment scale, topography is controlled by both the degree of glaciation, and the response of the drainage system to range-front faulting. The range-bounding normal faults are segmented along-strike, and fault uplift rates vary systematically, being greatest at the fault centres. Here catchments predominantly drain normal to the range-front fault, although the trend of some catchments is influenced by pre-existing tectonic fabrics related to Cretaceous (northeast-southwest trending) and early Miocene (northwest-southeast trending) extension. For catchments that drain through fault segment boundaries, one of two general morphologies occurs. Either large drainage basins form, capturing drainage area from neighbouring basins, or, when fault segment boundaries are en echelon, a series of small drainage basins may form as catchments as the inboard- and outboard- footwalls interact and respond to fault linkage. Quaternary glaciation affected all but the southern portions of each of the ranges, most extensively at the north-eastern range flank. Increased extent of glaciation within a catchment results in wider valley floors, steeper valley walls, and greater relief at elevations close to the ELA. Cirque formation occurs preferentially on the north-eastern range flank, where glaciers are sheltered from both solar radiation and snow re-distribution by the prevailing winds. Snow accumulation is promoted in this setting by the increased influx of wind-blown snow from the western side of the range crest, and large moraines extend beyond the eastern range front. For portions of the ranges affected by glaciation, range mean heights decrease along-strike by 1-2m per km to the north-west, similar to the rate of decrease in ELA and in the trend of cirque floor elevations. This suggests that a glacial "buzzsaw" effect controls the range mean heights.

KSC-2010-5779

NASA Image and Video Library

2010-11-16

San Luis Obispo, Calif. -- 101116-F-8290C-059 -- Roland Coelho and Ryan Nugent, students at California Polytechnic State University Cal Poly, integrate miniature research satellites called CubeSats into a Poly Picosatellite Orbital Deployer PPOD container. The PPOD and CubeSat Project were developed by Cal Poly and Stanford University’s Space Systems Development Lab for use on NASA’s Educational Launch of Nanosatellite ELaNa missions. Each CubeSat measures about 4-inches cubed and is about the same volume as a quart. The CubeSats weigh about 2.2 pounds, must conform to standard aerospace materials and must operate without propulsion. The satellites are being prepared to launch with NASA's Glory spacecraft aboard an Orbital Sciences Corp. Taurus XL rocket, targeted to lift off Feb. 23, 2011, from Vandenberg's Space Launch Complex 576-E. Glory is scheduled to collect data on the properties of aerosols and black carbon from its place in low Earth orbit. It also will help scientists understand how the sun's irradiance affects Earth's climate. Photo credit: U.S. Air Force/Jerry E. Clemens Jr.

KSC-2010-5780

NASA Image and Video Library

2010-11-16

San Luis Obispo, Calif. -- 101116-F-8290C-060 -- Roland Coelho, a student at California Polytechnic State University Cal Poly, inspects the integration alignment of miniature research satellites called a CubeSats into a Poly Picosatellite Orbital Deployer PPOD container. The PPOD and CubeSat Project were developed by Cal Poly and Stanford University’s Space Systems Development Lab for use on NASA’s Educational Launch of Nanosatellite ELaNa missions. Each CubeSat measures about 4-inches cubed and is about the same volume as a quart. The CubeSats weigh about 2.2 pounds, must conform to standard aerospace materials and must operate without propulsion. The satellites are being prepared to launch with NASA's Glory spacecraft aboard an Orbital Sciences Corp. Taurus XL rocket, targeted to lift off Feb. 23, 2011, from Vandenberg's Space Launch Complex 576-E. Glory is scheduled to collect data on the properties of aerosols and black carbon from its place in low Earth orbit. It also will help scientists understand how the sun's irradiance affects Earth's climate. Photo credit: U.S. Air Force/Jerry E. Clemens Jr.

KSC-2010-5778

NASA Image and Video Library

2010-11-16

San Luis Obispo, Calif. -- 101116-F-8290C-054 -- Roland Coelho and Ryan Nugent, students at California Polytechnic State University Cal Poly, integrate miniature research satellites called CubeSats into a Poly Picosatellite Orbital Deployer PPOD container. The PPOD and CubeSat Project were developed by Cal Poly and Stanford University’s Space Systems Development Lab for use on NASA’s Educational Launch of Nanosatellite ELaNa missions. Each CubeSat measures about 4-inches cubed and is about the same volume as a quart. The CubeSats weigh about 2.2 pounds, must conform to standard aerospace materials and must operate without propulsion. The satellites are being prepared to launch with NASA's Glory spacecraft aboard an Orbital Sciences Corp. Taurus XL rocket, targeted to lift off Feb. 23, 2011, from Vandenberg's Space Launch Complex 576-E. Glory is scheduled to collect data on the properties of aerosols and black carbon from its place in low Earth orbit. It also will help scientists understand how the sun's irradiance affects Earth's climate. Photo credit: U.S. Air Force/Jerry E. Clemens Jr.

VISCEL: A general-purpose computer program for analysis of linear viscoelastic structures (user's manual), volume 1

NASA Technical Reports Server (NTRS)

Gupta, K. K.; Akyuz, F. A.; Heer, E.

1972-01-01

This program, an extension of the linear equilibrium problem solver ELAS, is an updated and extended version of its earlier form (written in FORTRAN 2 for the IBM 7094 computer). A synchronized material property concept utilizing incremental time steps and the finite element matrix displacement approach has been adopted for the current analysis. A special option enables employment of constant time steps in the logarithmic scale, thereby reducing computational efforts resulting from accumulative material memory effects. A wide variety of structures with elastic or viscoelastic material properties can be analyzed by VISCEL. The program is written in FORTRAN 5 language for the Univac 1108 computer operating under the EXEC 8 system. Dynamic storage allocation is automatically effected by the program, and the user may request up to 195K core memory in a 260K Univac 1108/EXEC 8 machine. The physical program VISCEL, consisting of about 7200 instructions, has four distinct links (segments), and the compiled program occupies a maximum of about 11700 words decimal of core storage.

Intermittent chronic neutropenia in a patient with familial Mediterranean fever.

PubMed

Ganiou Tidjani, K; Ailal, F; Najib, J; Bellanné-Chantelot, C; Donadieu, J; Bousfiha, A A

2008-11-01

A 12-year-old daughter of consanguineous Moroccan parents was diagnosed with cyclic neutropenia, based on a combination of recurrent gingivostomatitis, a fluctuating neutrophil count, and several episodes of severe neutropenia. No ELA2 gene mutations were found. At age 19 years she presented with edema of the limbs, proteinuria and renal failure. Renal amyloidosis AA was diagnosed by biopsy. Gene mutations associated with family Mediterranean fever (FMF) were sought, and a homozygous mutation (M694V) was found in the MFEV gene. This is the novel finding of FMF that masqueraded as cyclic neutropenia. (c) 2008 Wiley-Liss, Inc.

Experimentally Determined Relationship between Extinction and Liquid Water Content.

DTIC Science & Technology

1981-04-01

throuoh 3c. Each type Yze - ly show, ,i linar ’ela . measure! ant’it Thi ’i -wpe t , s , ss om v , function cf toe ’,c ir ., ’ genera m h 3 mechanically ge...APR 01 0 BRUCE, C W BRUCE, Y P YEE UCLASSIIED ERADCO WASI-TfR-06 5 El EEE~hhETE-E ThE-- ADm2 / ASL-TR-0083 Reports Control Symbol OSD-1366...ATMOSPHERIC SCIENCES LABORATORY ~White Sands Misile Range, NM 88002 NOTICES isclaimers The findings in this r7_port ire not to be construed as an

Development of an object-oriented finite element program: application to metal-forming and impact simulations

NASA Astrophysics Data System (ADS)

Pantale, O.; Caperaa, S.; Rakotomalala, R.

2004-07-01

During the last 50 years, the development of better numerical methods and more powerful computers has been a major enterprise for the scientific community. In the same time, the finite element method has become a widely used tool for researchers and engineers. Recent advances in computational software have made possible to solve more physical and complex problems such as coupled problems, nonlinearities, high strain and high-strain rate problems. In this field, an accurate analysis of large deformation inelastic problems occurring in metal-forming or impact simulations is extremely important as a consequence of high amount of plastic flow. In this presentation, the object-oriented implementation, using the C++ language, of an explicit finite element code called DynELA is presented. The object-oriented programming (OOP) leads to better-structured codes for the finite element method and facilitates the development, the maintainability and the expandability of such codes. The most significant advantage of OOP is in the modeling of complex physical systems such as deformation processing where the overall complex problem is partitioned in individual sub-problems based on physical, mathematical or geometric reasoning. We first focus on the advantages of OOP for the development of scientific programs. Specific aspects of OOP, such as the inheritance mechanism, the operators overload procedure or the use of template classes are detailed. Then we present the approach used for the development of our finite element code through the presentation of the kinematics, conservative and constitutive laws and their respective implementation in C++. Finally, the efficiency and accuracy of our finite element program are investigated using a number of benchmark tests relative to metal forming and impact simulations.

Multi-year analysis of distributed glacier mass balance modelling and equilibrium line altitude on King George Island, Antarctic Peninsula

NASA Astrophysics Data System (ADS)

Falk, Ulrike; López, Damián A.; Silva-Busso, Adrián

2018-04-01

The South Shetland Islands are located at the northern tip of the Antarctic Peninsula (AP). This region was subject to strong warming trends in the atmospheric surface layer. Surface air temperature increased about 3 K in 50 years, concurrent with retreating glacier fronts, an increase in melt areas, ice surface lowering and rapid break-up and disintegration of ice shelves. The positive trend in surface air temperature has currently come to a halt. Observed surface air temperature lapse rates show a high variability during winter months (standard deviations up to ±1.0 K (100 m)-1) and a distinct spatial heterogeneity reflecting the impact of synoptic weather patterns. The increased mesocyclonic activity during the wintertime over the past decades in the study area results in intensified advection of warm, moist air with high temperatures and rain and leads to melt conditions on the ice cap, fixating surface air temperatures to the melting point. Its impact on winter accumulation results in the observed negative mass balance estimates. Six years of continuous glaciological measurements on mass balance stake transects as well as 5 years of climatological data time series are presented and a spatially distributed glacier energy balance melt model adapted and run based on these multi-year data sets. The glaciological surface mass balance model is generally in good agreement with observations, except for atmospheric conditions promoting snow drift by high wind speeds, turbulence-driven snow deposition and snow layer erosion by rain. No drift in the difference between simulated mass balance and mass balance measurements can be seen over the course of the 5-year model run period. The winter accumulation does not suffice to compensate for the high variability in summer ablation. The results are analysed to assess changes in meltwater input to the coastal waters, specific glacier mass balance and the equilibrium line altitude (ELA). The Fourcade Glacier catchment drains into Potter cove, has an area of 23.6 km2 and is glacierized to 93.8 %. Annual discharge from Fourcade Glacier into Potter Cove is estimated to q ¯ = 25±6 hm3 yr-1 with the standard deviation of 8 % annotating the high interannual variability. The average ELA calculated from our own glaciological observations on Fourcade Glacier over the time period 2010 to 2015 amounts to 260±20 m. Published studies suggest rather stable conditions of slightly negative glacier mass balance until the mid-1980s with an ELA of approx. 150 m. The calculated accumulation area ratio suggests dramatic changes in the future extent of the inland ice cap for the South Shetland Islands.

Debris-covered glaciers during the LGM and Lateglacial at the eastern margin of the Alps

NASA Astrophysics Data System (ADS)

Seidl, Sabrina; Reitner, Jürgen M.; Wagreich, Michael

2013-04-01

We present the reconstruction of paleo-glaciers in the easternmost part of the Alps (Schneeberg mountain) with the main focus on sedimentology, chronology and glacial dynamics. The area is dominantly made up of limestone bedrock and hence characterized by steep slopes and cirques. Two juvenile moraine-systems can be deciphered based on geological mapping. The major system is characterized by an up to 60 m high latero-frontal dump moraine with a prominent breach-lobe moraine in a lateral position. It is regarded to represent the Last Glacial Maximum (LGM; Würm Pleniglacial). The other system is much smaller and was formed most probably during the Würm Lateglacial. The angular to subangular shape of the clasts and the abundant boulders on top of the ridges indicate a high portion of passive (Boulton, 1978) i.e. supraglacial and englacial transport of debris before deposition.Thus the model of a debris-covered glacier is favored to explain both landforms and as well the corresponding sediment facies. For the pleniglacial moraine such an assumption is backed by a low accumulation/ablation area ratio (AAR) of around 1:1 based on the reconstruction of the equilibrium line altitude (ELA) using the maximum elevation of lateral moraines (MELM; Lichtenecker, 1938). Furthermore as there is no indication of a former glacier snout glacio-fluvial processes should have played a limited role in sediment transport into the forefield. Such setting pinpoints to very cold-arid conditions, which are as well found in paleo-climate reconstructions of the eastern foreland (Frenzel et al. 1992). Boulton, G.S., 1978: Boulder shapes and grain-size distribution of debris as indicators of transport paths through a glacier and till genesis.- Sedimentology, 25, 773-799. Lichtenecker, N.,1938. Die gegenwärtige und die eiszeitliche Schneegrenze in den Ostalpen. In: Verhandlungen der III. Internationalen Quartär - Konferenz, Vienna, 1936, 141-147. Frenzel, B., Pecsi, M. & Velichko, A. A., 1992. Atlas of Paleoclimate and Paleoenvironments of the Northern Hemisphere: Late Pleistocene - Holocene. Geogr. Res. Institute, G. Fischer Verlag, Budapest-Stuttgart.

Cyclic neutropenia and severe congenital neutropenia in patients with a shared ELANE mutation and paternal haplotype: evidence for phenotype determination by modifying genes.

PubMed

Newburger, Peter E; Pindyck, Talia N; Zhu, Zhiqing; Bolyard, Audrey Anna; Aprikyan, Andrew A G; Dale, David C; Smith, Gary D; Boxer, Laurence A

2010-08-01

Cyclic neutropenia (CN) and severe congenital neutropenia (SCN) are disorders of neutrophil production that differ markedly in disease severity. Mutations of the ELANE gene (the symbol recently replacing ELA2) are considered largely responsible for most cases of CN and SCN, but specific mutations are typically associated with one or the other. We performed ELANE genotyping on all individuals and paternal sperm in an SCN kindred with eight SCN progeny of a sperm donor and six different mothers. One patient with CN had the same S97L ELANE mutation as seven patients with the SCN phenotype. The mutant allele was detected in the donor's spermatozoa, representing 18% of the ELANE gene pool, but not in DNA from his lymphocytes, neutrophils, or buccal mucosa, indicating gonadal mosaicism. The coexistence of CN and SCN phenotypes in this kindred with a shared paternal haplotype strongly suggests both a role for modifying genes in determination of congenital neutropenia disease phenotypes, and the classification of CN and SCN within a spectrum of phenotypes expressing varying degrees of the same disease process. (c) 2010 Wiley-Liss, Inc.

Rangewide glaciation in the Sierra Nevada, California

USGS Publications Warehouse

Moore, James G.; Moring, Barry C.

2013-01-01

The 600-km-long Sierra Nevada underwent extensive Pleistocene glaciation except for its southernmost 100 km. Presently, ∼1700 small glaciers and ice masses near the crest of the range occur above 3250 m in elevation; these covered an area of ∼50 km2 in 1972. Fourteen of the largest glaciers decreased by about one half in area during the period from 1900 to 2004.Rock glaciers, generally glacial ice covered by 1–10 m of rockfall debris, occur in about the same span of the range as ice and permanent snowfields. They are, on average, lower by 200–300 m, apparently because of the insulating layer of rocky rubble that protects their internal ice from the sun’s heat and from wind.The principal Pleistocene glacial stages are the Sherwin (ca. 820 ka), Tahoe (170–130 and ca. 70 ka), Tioga (14–28 ka), and Recess Peak (13 ka). Some 7040 glacial lakes, produced primarily by quarrying from bedrock, were mostly exposed after recession of the Tioga glacial stage. The lakes largely mark the area of primary snow accumulation. Below the lower limit of the lakes, ice flowed downward into river-cut canyons, forming major trunk glaciers within the zone of ablation.The range is in general a westward-tilted block upfaulted on its east side. Therefore, the main late Pleistocene trunk glaciers (Tahoe/Tioga) west of the crest extend 25–60 km, whereas those east of the crest extend only 5–20 km. Because of higher precipitation northward, glacial features such as the toes of existing glaciers and rock glaciers, as well as the late season present-day snowline, all decrease in elevation northward. Likewise, the elevation of the lower limit of glacial lakes, an indication of the zone of snow accumulation during the late Pleistocene, decreases about the same degree. This similarity suggests that the overall climate patterns of the late Pleistocene, though cooler, were similar to those of today. The east slope glaciers show a similar northward depression, but they are ∼500–1000 m higher.The upper part of the glacial system was erosive over a broad highland area as the evenly distributed ice in the accumulation zone moved to lower elevation. The abundant lake basins record this erosive action. The lower part of the glacier system was largely confined to major preexisting river canyons in which melting dominated. The average of rangewide estimates of the equilibrium line altitude (ELA)—the boundary between the upper snow and ice accumulation zone and the lower ablation zone—of many late Pleistocene glaciers parallels, and is only 200–300 m above, the altitude of the lower limit of the lakes. Hence, the lake zone provides a means of estimating the ELA.

Extent, timing, and climatic significance of latest Pleistocene and Holocene glaciation in the Sierra Nevada, California

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clark, Douglas Howe

Despite more than a century of study, scant attention has been paid to the glacial record in the northern end of the Sierra Nevada, and to the smaller moraines deposited after the retreat of the Tioga (last glacial maximum) glaciers. Equilibrium-line altitude (ELA) estimates of the ice fields indicate that the Tioga ELA gradients there are consistent with similar estimates for the southern half of the range, and with an intensification of the modern temperature/precipitation pattern in the region. The Recess Peak advance has traditionally been considered to be mid-Neoglacial age, about 2--3,000 yr B.P., on the basis of relativemore » weathering estimates. Sediment cores of lakes dammed behind moraines correlative with Recess Peak in four widely spaced sites yields a series of high-resolution AMS radiocarbon dates which demonstrate that Recess Peak glaciers retreated before ~13,100 cal yr B.P.. This minimum limiting age indicates that the advance predates the North Atlantic Younger Dryas cooling. It also implies that there have been no advances larger than the Matthes in the roughly 12,000 year interval between it and the Recess Peak advance. This finding casts doubt on several recent studies that claim Younger Dryas glacier advances in western North America. The 13,100 cal yr B.P. date is also a minimum age for deglaciation of the sample sites used to calibrate the in situ production rates of cosmogenic 10Be and 26Al. The discrepancy between this age and the 11,000 cal yr B.P. exposure age assumed in the original calibration introduces a large (> 19%) potential error in late-Pleistocene exposure ages calculated using these production rates.« less

Holocene glacier and climate variations in Vestfirðir, Iceland, from the modeling of Drangajökull ice cap

NASA Astrophysics Data System (ADS)

Anderson, Leif S.; Flowers, Gwenn E.; Jarosch, Alexander H.; Aðalgeirsdóttir, Guðfinna Th; Geirsdóttir, Áslaug; Miller, Gifford H.; Harning, David J.; Thorsteinsson, Thorsteinn; Magnússon, Eyjólfur; Pálsson, Finnur

2018-06-01

Drangajökull is a maritime ice cap located in northwest (Vestfirðir) Iceland. Drangajökull's evolution is therefore closely linked to atmospheric and ocean variability. In order to better constrain the Holocene climate and glacier history of Vestfirðir we model the past evolution of Drangajökull ice cap. Simulations from 10 ka to present are forced by general circulation model output, ice-core-based temperature reconstructions, and sea-surface temperature reconstructions. Based on these 10-thousand year simulations, Drangajökull did not persist through the Holocene. We estimate that air temperatures were 2.5-3.0 °C higher during the Holocene Thermal Maximum than the local 1960-1990 average. Simulations support Drangajökull's late Holocene inception between 2 and 1 ka, though intermittent ice likely occupied cirques as early as 2.6 ka. Drangajökull is primarily a Little Ice Age ice cap: it expanded between 1300 and 1750 CE, with the most rapid growth occurring between 1600 and 1750 CE. The maximum Holocene extent of Drangajökull occurred between 1700 and 1925 CE, despite the lowest late Holocene temperatures, occurring between 1650 and 1720 CE. Between 1700 and 1925 CE temperatures were likely 0.6-0.8 °C lower than the 1950-2015 reference temperature. The modern equilibrium line altitude (ELA) is bracketed by topographic thresholds: a 1 °C temperature increase from the modern ELA would eliminate the ice cap's accumulation area, while a reduction of 0.5 °C would lead to the rapid expansion of the ice cap across Vestfirðir. The proximity of Drangajökull to topographic thresholds may explain its late inception and rapid expansion during the Little Ice Age.

Early life stress and later peer distress on depressive behavior in adolescent female rats: Effects of a novel intervention on GABA and D2 receptors.

PubMed

Lukkes, Jodi L; Meda, Shirisha; Thompson, Britta S; Freund, Nadja; Andersen, Susan L

2017-07-14

Early life adversity (ELA) increases the risk of depression during adolescence that may result from a decline in parvalbumin (PVB) secondary to increased neuroinflammation. In this study, we investigated depressive-like behavior following exposure to two different types of stressors that are relevant for their developmental period: 1) chronic ELA (maternal separation; MS) and 2) an acute emotional stressor during adolescence (witnessing their peers receive multiple shocks; WIT), and their interaction. We also determined whether reducing inflammation by cyclooxygenase-2 (COX-2) inhibition would prevent the onset of depressive-like behavior. Female Sprague-Dawley rat pups underwent MS for four-hours/day or received typical care (CON) between postnatal days (P) 2 and P20. A COX-2 inhibitor (COX-2I) or vehicle was administered every other day between P30 and P38. Subjects were tested for learned helplessness to assess depressive-like behavior at P40 (adolescence). MS females demonstrated increased escape latency and decreased PVB in the prefrontal cortex (PFC) and dorsal raphe that were attenuated by COX-2I intervention. Helplessness was also associated with an increase in D2 receptors in the accumbens. In contrast, WIT elevated escape latency in CON, but reduced latency in MS females. Furthermore, COX-2I intervention decreased escape latency in both CON and MS after WIT. WIT reduced PVB levels in the basolateral amygdala and increased PFC levels to CON levels. Our data suggest that decreased PVB in the PFC is important for the expression of depressive-like behavior and suggest that COX-2I intervention may provide a novel prevention for depression. Copyright © 2017 Elsevier B.V. All rights reserved.

Assessment and application of a snowblow modelling approach for identifying enhanced snow accumulation in areas of former glaciation

NASA Astrophysics Data System (ADS)

Mills, Stephanie; Smith, Michael; Le Brocq, Anne; Ardakova, Ekaterina; Hillier, John; Boston, Clare

2016-04-01

The redistribution of snow by wind can play an important role in providing additional mass to the surface of glaciers and can, therefore, have an impact on the glacier's surface mass balance. In areas of marginal glaciation, this local topo-climatic effect may be prove crucial for the initiation and survival of glaciers, whilst it can also increase heterogeneity in the distribution of snow on ice caps and ice sheets. We present a newly developed snowblow model which calculates spatial variations in relative snow accumulation that result from variations in topography. We apply this model to areas of former marginal glaciation in the Brecon Beacons, Wales and an area of former plateau icefield glaciation in the Monadhliath, Scotland. We can then determine whether redistribution by snow can help explain variations in the estimated equilibrium line altitudes (ELAs) of these former glaciers. Specifically, we compare the areas where snow is modelled as accumulating, to the reconstructed glacier surface, which is based on mapped moraines believed to be of Younger Dryas age. The model is applied to 30 m resolution DEMs and potential snow accumulation is simulated from different wind directions in order to determine the most likely contributing sector. Total snow accumulation in sub-set areas is then calculated and compared to the reconstructed glacier area. The results suggest that areas with larger amounts of snow accumulation often correspond with those where the ELA is lower than surrounding glaciers and vice versa, in both the marginal and icefield setting, suggesting that the role of snowblow in supplying additional mass to the surface of glaciers is significant.

Trans-pacific glacial response to the Antarctic Cold Reversal in the southern mid-latitudes

NASA Astrophysics Data System (ADS)

Sagredo, Esteban A.; Kaplan, Michael R.; Araya, Paola S.; Lowell, Thomas V.; Aravena, Juan C.; Moreno, Patricio I.; Kelly, Meredith A.; Schaefer, Joerg M.

2018-05-01

Elucidating the timing and regional extent of abrupt climate events during the last glacial-interglacial transition (∼18-11.5 ka) is critical for identifying spatial patterns and mechanisms responsible for large-magnitude climate events. The record of climate change in the Southern Hemisphere during this time period, however, remains scarce and unevenly distributed. We present new geomorphic, chronological, and equilibrium line altitude (ELA) data from a climatically sensitive mountain glacier at Monte San Lorenzo (47°S), Central Patagonia. Twenty-four new cosmogenic 10Be exposure ages from moraines provide a comprehensive glacial record in the mid-latitudes of South America, which constrain the timing, spatial extent and magnitude of glacial fluctuations during the Antarctic Cold Reversal (ACR, ∼14.5-12.9 ka). Río Tranquilo glacier advanced and reached a maximum extent at 13.9 ± 0.7 ka. Three additional inboard moraines afford statistically similar ages, indicating repeated glacier expansions or marginal fluctuations over the ACR. Our record represents the northernmost robust evidence of glacial fluctuations during the ACR in southern South America, documenting not only the timing of the ACR maximum, but also the sequence of glacier changes within this climate event. Based on ELA reconstructions, we estimate a cooling of >1.6-1.8 °C at the peak of the ACR. The Río Tranquilo record along with existing glacial reconstructions from New Zealand (43°S) and paleovegetation records from northwestern (41°S) and central-west (45°S) Patagonia, suggest an uniform trans-Pacific glacier-climate response to an ACR trigger across the southern mid-latitudes. We posit that the equatorial migration of the southern westerly winds provides an adequate mechanism to propagate a common ACR signal across the Southern Hemisphere.

On Ensino de Astronomia: Desafios para Implantação

NASA Astrophysics Data System (ADS)

Faria, R. Z.; Voelzke, M. R.

2008-09-01

Em 2002 o ensino de Astronomia foi proposto como um dos temas estruturadores pelos Parâmetros Curriculares Nacionais e sugerido como facilitador para que o aluno compreendesse a Física como construção humana e parte do seu mundo vivencial, mas raramente seus conceitos foram ensinados. A presente pesquisa discute dois aspectos relacionados à abordagem de Astronomia. O primeiro aspecto é se ela está sendo abordada pelos professores do Ensino Médio e o segundo, aborda a maneira como ela está sendo ensinada. Optou-se pela aplicação de um questionário a partir do 2° semestre de 2006 e durante o ano de 2007 com professores que ministram a disciplina de Física, os quais trabalham em escolas estaduais em Rio Grande da Serra, Ribeirão Pires e Mauá no estado São Paulo. Dos 66,2% dos professores que responderam ao questionário nos municípios de Rio Grande da Serra, Ribeirão Pires e Mauá, 57,4% não aplicaram nenhum tópico de astronomia, 70,2% não utilizaram laboratório, 89,4% não utilizaram qualquer tipo de programa computacional, 83,0% nunca fizeram visitas com alunos a museus e planetários e 38,3% não indicaram qualquer tipo de livro ou revista referente à astronomia aos seus alunos. Mesmo considerando a Astronomia um conteúdo potencialmente significativo, esta não fez parte dos planejamentos escolares. Portanto são necessárias propostas que visem estratégias para a educação continuada dos professores como, por exemplo, cursos específicos sobre o ensino em Astronomia.